Adaptor Protein Complex Subunits
Adaptor Protein Complex 1
Adaptor Protein Complex 2
Adaptor Protein Complex 4
Adaptor Protein Complex delta Subunits
Adaptor Protein Complex mu Subunits
Adaptor Proteins, Vesicular Transport
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.
Adaptor Protein Complex gamma Subunits
Adaptor Protein Complex beta Subunits
Adaptor Protein Complex alpha Subunits
Adaptor Proteins, Signal Transducing
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.
Monomeric Clathrin Assembly Proteins
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Molecular Sequence Annotation
Sequence Analysis, DNA
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Reagent Kits, Diagnostic
Sensitivity and Specificity
A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)
Academies and Institutes
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
National Human Genome Research Institute (U.S.)
Mental Retardation, X-Linked
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
Chromosomes, Human, X
Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. (1/7)Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes also play a pivotal role in the cargo selection by recognizing the sorting signals within the cytoplasmic tail of integral membrane proteins. Six distinct AP complexes have been identified. AP-2 mediates endocytosis from the plasma membrane, while AP-1, AP-3 and AP-4 play a role in the endosomal/lysosomal sorting pathways. Moreover, tissue-specific sorting events such as the basolateral sorting in polarized epithelial cells and the biogenesis of specialized organelles including melanosomes and synaptic vesicles are also regulated by members of AP complexes. The application of a variety of methodologies have gradually revealed the physiological role of AP complexes. (+info)
Crystal structure of the clathrin adaptor protein 1 core. (2/7)The heterotetrameric adaptor proteins (AP complexes) link the outer lattice of clathrin-coated vesicles with membrane-anchored cargo molecules. We report the crystal structure of the core of the AP-1 complex, which functions in the trans-Golgi network (TGN). Packing of complexes in the crystal generates an exceptionally long (1,135-A) unit-cell axis, but the 6-fold noncrystallographic redundancy yields an excellent map at 4-A resolution. The AP-1 core comprises N-terminal fragments of the two large chains, beta1 and gamma, and the intact medium and small chains, micro1 and sigma1. Its molecular architecture closely resembles that of the core of AP-2, the plasma-membrane-specific adaptor, for which a structure has been determined. Both structures represent an "inactive" conformation with respect to binding of cargo with a tyrosine-based sorting signal. TGN localization of AP-1 depends on the small GTPase, Arf1, and the phosphoinositide, PI-4-P. We show that directed mutations of residues at a particular corner of the gamma chain prevent recruitment to the TGN in cells and diminish PI-4-P-dependent, but not Arf1-dependent, liposome binding in vitro. (+info)
The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function. (3/7)Regulation of Src family kinase (SFK) activity is indispensable for a functional immune system and embryogenesis. The activity of SFKs is inhibited by the presence of the carboxy-terminal Src kinase (Csk) at the cell membrane. Thus, recruitment of cytosolic Csk to the membrane-associated SFKs is crucial for its regulatory function. Previous studies utilizing in vitro and transgenic models suggested that the Csk-binding protein (Cbp), also known as phosphoprotein associated with glycosphingolipid microdomains (PAG), is the membrane adaptor for Csk. However, loss-of-function genetic evidence to support this notion was lacking. Herein, we demonstrate that the targeted disruption of the cbp gene in mice has no effect on embryogenesis, thymic development, or T-cell functions in vivo. Moreover, recruitment of Csk to the specialized membrane compartment of "lipid rafts" is not impaired by Cbp deficiency. Our results indicate that Cbp is dispensable for the recruitment of Csk to the membrane and that another Csk adaptor, yet to be discovered, compensates for the loss of Cbp. (+info)
Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. (4/7)Ligand-receptor complexes are internalized by a variety of endocytic mechanisms. Some are initiated within clathrin-coated membranes, whereas others involve lipid microdomains of the plasma membrane. In neurons, where alternative targeting to short- or long-range trafficking routes underpins the differential processing of synaptic vesicle components and neurotrophin receptors, the mechanism giving access to the axonal retrograde pathway remains unknown. To investigate this sorting process, we examined the internalization of a tetanus neurotoxin fragment (TeNT HC), which shares axonal carriers with neurotrophins and their receptors. Previous studies have shown that the TeNT HC receptor, which comprises polysialogangliosides, resides in lipid microdomains. We demonstrate that TeNT HC internalization also relies on a specialized clathrin-mediated pathway, which is independent of synaptic vesicle recycling. Moreover, unlike transferrin uptake, this AP-2-dependent process is independent of epsin1. These findings identify a pathway for TeNT, beginning with the binding to a lipid raft component (GD1b) and followed by dissociation from GD1b as the toxin internalizes via a clathrin-mediated mechanism using a specific subset of adaptor proteins. (+info)
Long double-stranded RNA produces specific gene downregulation in Giardia lamblia. (5/7)(+info)
The fifth adaptor protein complex. (6/7)(+info)
Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit mu1A. (7/7)(+info)
Saez-Rodriguez Group - COMBINE
After obtaining my Diploma in Computer Engineering from the Polytechnic School at University of Patras I continued my Master studies with specialization in Bioinformatics at National and Kapodistrian University. During the last year of my masters degree I spent half of my research term at INRIA Sophia--Antipolis, as an intern in the Algorithms Biology Structure (ABS) team where I dealt with Cryo--Electron Microscopy maps segmentation to detect the individual protein complexs subunits by heavily relying on computational geometry methods. Afterwards, I joined Dr. Julio Saez-Rodriguezs group at the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) as an intern where my main project was the analysis of microarray gene expression profiles of primary tumours and cell lines from colorectal cancer using consensus-based unsupervised clustering and association to drug response. Currently, I conduct my PhD research at Dr. Julio Saez-Rodriguezs group at the Joint ...
Chemotherapy Related Anemia in Patients With Non-Myeloid Malignancies - No Study Results Posted - ClinicalTrials.gov
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
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Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells - [email protected]
Several lines of evidence suggest that cancer progression is associated with up-regulation or reactivation of telomerase and the underlying mechanism remains an active area of research. The heterotrimeric MRN complex, consisting of Mre11, Rad50 and Nbs1, which is required for the repair of double-strand breaks, plays a key role in telomere length maintenance. In this study, we show significant differences in the levels of expression of MRN complex subunits among various cancer cells and somatic cells. Notably, siRNA-mediated depletion of any of the subunits of MRN complex led to complete ablation of other subunits of the complex. Treatment of leukemia and prostate cancer cells with etoposide lead to increased expression of MRN complex subunits, with concomitant decrease in the levels of telomerase activity, compared to breast cancer cells. These studies raise the possibility of developing anti-cancer drugs targeting MRN complex subunits to sensitize a subset of cancer cells to radio- and/or ...
Communication Received from the Resident Representative of Sweden to the Agency | IAEA
The Director General has received a communication dated 18 October 2012 from the Resident Representative of Sweden to the Agency, regarding a press statement issued by the Swedish Radiation Safety Authority concerning the incident at the Ringhals and Forsmark nuclear power plants, which took place on 9 October 2012.... ...
Rat Prolyl endopeptidase-like (PREPL) ELISA Kit - Abbkine - Antibodies, proteins, biochemicals, assay kits for life science...
PREPL belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene. The longest deduced protein contains 727 amino acids and has a propeller domain in its N-terminal half and a catalytic domain, including the catalytic triad (ser, asp, his) essential for serine peptidases, in its C-terminal half. In sharp contrast to PREP and oligopeptidase B, which require both amino- and carboxy-terminal sequences for activity, PREPL activity appeared to depend only on the carboxy-terminal domain.
Ako začať meniť svoj život k lepšiemu - nikdy nie je neskoro!!! - Ako sa mať lepšie
Nezáleží ako si žil svoj život doteraz, že si nikdy predtým neriskoval, neskúšal veci dovtedy, kým sa ti nepodarili. Vždy môžeš začať od nuly. A možno tento začiatok roka je ten moment. Možno sa stretneš s názormi ľudí v tvojom okolí, ktoré nebudú zapadať do tvojich plánov. Možno sa budeš musieť vzdať niektorých priateľstiev, aby si nedovolil týmto ľuďom zmariť tvoje úsilie. Možno sa budeš musieť vzdať aj niektorých vecí, ktoré boli doteraz pre teba pohodlné a dávali ti pocit bezpečia… No nezabúdaj, že nový život nezískaš rovnakým prístupom, ktorý si poznal doteraz. Keď ale nazbieraš odvahu vystúpiť zo svojej komfortnej zóny a dokážeš „zaťať zuby ísť proti svojim zlozvykom, privedie ťa táto cesta k lepšiemu životu.. Usporiadanie, preplánovanie, robenie chýb, z ktorých sa poučíme, mať chvíle iba pre seba, učiť sa nové veci, vyhýbať sa rozptýleniam, zameriavať pozornosť na to, čo je pre mňa dôležité, ...
Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8 | Cilia | Full Text
Assembly of primary cilia relies on vesicular trafficking towards the cilium base and intraflagellar transport (IFT) between the base and distal tip of the cilium. Recent studies have identified several key regulators of these processes, including Rab GTPases such as Rab8 and Rab11, the Rab8 guanine nucleotide exchange factor Rabin8, and the transport protein particle (TRAPP) components TRAPPC3, -C9, and -C10, which physically interact with each other and function together with Bardet Biedl syndrome (BBS) proteins in ciliary membrane biogenesis. However, despite recent advances, the exact molecular mechanisms by which these proteins interact and target to the basal body to promote ciliogenesis are not fully understood. We surveyed the human proteome for novel ASPM, SPD-2, Hydin (ASH) domain-containing proteins. We identified the TRAPP complex subunits TRAPPC8, -9, -10, -11, and -13 as novel ASH domain-containing proteins. In addition to a C-terminal ASH domain region, we predict that the N-terminus of
Biomolecules | Free Full-Text | Prolyl Endopeptidase-Like Facilitates the α-Synuclein Aggregation Seeding, and This Effect Is...
The aggregation of α-synuclein (α-Syn) is a characteristic of Parkinson’s disease (PD). α-Syn oligomerization/aggregation is accelerated by the serine peptidase, prolyl oligopeptidase (POP). Factors that affect POP conformation, including most of its inhibitors and an impairing mutation in its active site, influence the acceleration of α-Syn aggregation resulting from the interaction of these proteins. It is noteworthy, however, that α-Syn is not cleaved by POP. Prolyl endopeptidase-like (PREPL) protein is structurally related to the serine peptidases belonging to the POP family. Based on the α-Syn–POP studies and knowing that PREPL may contribute to the regulation of synaptic vesicle exocytosis, when this protein can encounter α-Syn, we investigated the α-Syn–PREPL interaction. The binding of these two human proteins was observed with an apparent affinity constant of about 5.7 μM and, as in the α-Syn assays with POP, the
Function: Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis (By similarity ...
List of adaptins
Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a ... 2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. PMC 3191125. PMID ... Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". Journal ...
The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition ... "Entrez Gene: AP4M1 adaptor-related protein complex 4, mu 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene. This gene encodes a subunit of the ... 2001). "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4". J. Biol. Chem. 276 (16): 13145-52. ...
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... Dell'Angelica EC, Mullins C, Bonifacino JS (Apr 1999). "AP-4, a novel protein complex related to clathrin adaptors". J Biol ...
"Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit". Human AP3S1 genome location and AP3S1 gene details page ... "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". ... AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene. GRCh38: Ensembl release 89: ... Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex ...
"Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit". Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH ... AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene. AP2A2 has been shown to interact with ... the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes ... "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265-9. doi:10.1074/jbc.271.9. ...
"Entrez Gene: AP3B1 adaptor-related protein complex 3, beta 1 subunit". GeneReviews/NCBI/NIH/UW entry on Hermansky-Pudlak ... AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene. This gene encodes a protein that may play ... The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin ... Dell'Angelica EC, Ooi CE, Bonifacino JS (Jun 1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". The Journal ...
AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene. Adaptor protein complex 1 is found at ... "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Huo L, Teng Z, Wang H, Liu X (March 2019). "A novel ... The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. ... December 2006). "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked ...
... also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 ... Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): ... an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. ... Ligon LA, Shelly SS, Tokito M, Holzbaur EL (2003). "The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential ...
... -S associates with two adaptor proteins: DAP10 and DAP12. DAP10 recruits the p85 subunit of PI3K and a complex of Grb2 and ... adaptor protein and transduces the signal after the ligand binding by recruiting the p85 subunit of PI3K and Grb2-Vav1 complex ... DAP12 bears ITAM motif and activates protein tyrosine kinases Syk and Zap70 signalling. NKG2D ligands are induced-self proteins ... In mice, proteins from orthologous RAET1/ULBP family fall into three subfamilies: Rae-1, H60, and MULT-1. ULBP2 is a stress- ...
"Entrez Gene: AP3S2 adaptor-related protein complex 3, sigma 2 subunit". CS1 maint: discouraged parameter (link) Dell'Angelica, ... AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. AP3S2 has been shown to interact with ... Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (Apr 1997). "AP-3: an adaptor-like protein complex with ... Dell'Angelica EC, Ooi CE, Bonifacino JS (1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". J. Biol. Chem. ...
"Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit". Human AP3B2 genome location and AP3B2 gene details page ... AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene. GRCh38: Ensembl release 89: ... 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917-28. doi:10.1093/emboj/16.5.917. ... Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin". ...
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
"Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, ... AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene. The protein encoded by this gene is one of ... Kim YM, Benovic JL (Aug 2002). "Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein- ... "Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation". The EMBO ...
"Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit". Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, ... AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene. This gene encodes a subunit of the ... heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ...
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. Adaptor protein complex 1 is found at the ... "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; ... The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ... Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote ...
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene. AP3D1 is a subunit of the AP3 adaptor- ... "Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit". CS1 maint: discouraged parameter (link) Martinez-Arca S ... "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting ... Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". ...
This gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor ... "Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot ... AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene. ... complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. AP1M2 has been ...
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the ... "Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ... AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a ...
X-linked mental retardation
AP1S2: AP-1 complex subunit sigma-2. Adaptor protein complex 1 is found on the cytoplasmic face of vesicles located at the ... "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Piccini M, Vitelli F, Bruttini M, Pober BR, Jonsson JJ ... "Mutations in the Gene Encoding the Sigma 2 Subunit of the Adaptor Protein 1 Complex, AP1S2, Cause X-Linked Mental Retardation ... This nucleolar protein is involved in the processing and modification of tRNA. GDI1: RabGDI alpha makes a complex with ...
The family routinely lies on the clathrin adaptor complex 3 beta-1 subunit proteins. The exact function of DUF 1682 is unclear ... The final protein is thought to be translated from the endoplasmic reticulum into the cytoplasm of the cell. The protein is ... The portion of the protein which extends into the cytosol is predicted to be highly phosphorylated as the protein's ... cAMP-responsive element binding protein (CREB), PAR b ZIP family and Sp4 Transcription Factor. NRF1 encodes a protein which ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene. Adaptins are important components of ...
All ATP-dependent chromatin-remodeling complexes possess a sub unit of ATPase that belongs to the SNF2 superfamily of proteins ... hADA3 may act as an adaptor protein linking transcription factors with other HAT complexes. In the absence of hADA3, TP53 ... ATP-dependent chromatin remodeling complexes. Specific protein complexes, known as histone-modifying complexes catalyze ... These protein complexes have a common ATPase domain and energy from the hydrolysis of ATP allows these remodeling complexes to ...
The Crm1 is pulled to the large 60S subunit by the help of an adapter protein called Nmd3. The adapter protein for the 40S unit ... of this complex requires the help of an upstream activating factor or UAF that associates with TATA-box binding protein and the ... and 5S rRNA and 46 ribosomal proteins) and a small 40S subunit (which contains the 18S rRNA and 33 ribosomal proteins). The ... At the 5' end of rRNA transcripts, small subunit ribosomal proteins (Rps) and non-ribosomal factors assemble with the pre-RNA ...
Sec61 alpha 1
... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... 2000). "Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes ...
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein ... 1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". J. Biol. Chem. 273 (47 ... 1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 ( ... "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module". J ...
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located ... This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that ... Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG ... Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins ...
"Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit". Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat ... AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene. One of two major clathrin-associated ... Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. ... "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1-2): ...
Together with α4 and PP2A, MID1 can form a ternary complex in which α4 acts as an adaptor protein. The data so far indicate ... July 2012). "Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering ... The MID1 gene encodes a 667 amino acid protein that belongs to the TRIM family. MID1 protein consists of a conserved N-terminal ... MID1 is a protein that belongs to the Tripartite motif family (TRIM) and is also known as TRIM18. The MID1 gene is located on ...
Sedimentation Velocity Analysis of Heterogeneous Protein-Protein Interactions: Lamm Equation Modeling and Sedimentation ... The ribosomes, membranes and Golgi complexes can be separated by another technique called density gradient centrifugation. ... The rotors may come with different adapters to hold various sizes of test tubes, bottles, or microtiter plates. ... showed that under different conditions the large homogeneous particles could be broken down into discrete subunits. The ...
Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Cav1.2) is a protein that in humans is encoded by ... The calcium channel consists of a complex of alpha-1, alpha-2/delta and beta subunits in a 1:1:1 ratio. The S3-S4 linkers of ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library ... "A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit". FEBS Letters. 384 ...
The assembled complex of hslV (blue) and hslU (red) from E. coli. This complex of heat shock proteins is thought to resemble ... The complex formed with the specialized β subunits is known as the immunoproteasome. Another β5i variant subunit, β5t, is ... the SCF itself is regulated by the APC via ubiquitination of the adaptor protein, Skp2, which prevents SCF activity before the ... Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks ...
Innate immune system
Bacteria and fungi may form complex biofilms, protecting from immune cells and proteins; biofilms are present in the chronic ... In parallel, when toll-like receptors in the endocytic compartments recognize a virus the activation of the adaptor protein ... where the transglutaminase polymerizes 210 kDa subunits of a plasma-clotting protein. On the other hand, in the horseshoe crab ... This leads to antiviral protein production, such as protein kinase R, which inhibits viral protein synthesis, or the 2′,5′- ...
Cyclin-dependent kinase 4
It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of ... 1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio. ... cyclin-dependent protein kinase holoenzyme complex. • nuclear membrane. • membrane. • transcription factor complex. • ... The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene ...
Tumor necrosis factor alpha
positive regulation of protein complex assembly. • protein kinase B signaling. • positive regulation of cytokine production. • ... This dissociation enables the adaptor protein TRADD to bind to the death domain, serving as a platform for subsequent protein ... On the other hand, activated caspases cleave several components of the NF-κB pathway, including RIP, IKK, and the subunits of ... positive regulation of protein complex disassembly. • regulation of cell proliferation. • cellular response to amino acid ...
Ionizable residues in the transmembrane domain of each subunit form a polar network of interactions that hold the complex ... to bind to the ITAM and activated ZAP-70 phosphorylates tyrosines on the adaptor protein LAT, which then attracts PLC-γ. Other ... The TCR complex. The TCR receptor complex is an octomeric complex of variable TCR receptor α and β chains with three ... Associated molecules of the TCR complex involved in T-cell activation. The essential function of the TCR complex is to ...
... essential adapter proteins in TLR signaling), they were still able to induce inflammatory responses, increase T cell activation ... clippings as antigen on their cell surface by coupling them to a special receptor known as a major histocompatibility complex ( ... Medzhitov R, Preston-Hurlburt P, Janeway CA (July 1997). "A human homologue of the Drosophila Toll protein signals activation ...
GTP-binding protein regulators
Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in ... and thus requires another class of regulatory proteins to accelerate this activity, the GTPase activating proteins (GAPs). ... GTP-Binding+Protein+Regulators at the US National Library of Medicine Medical Subject Headings (MeSH) ...
The adaptor molecules were eventually shown to be tRNAs and the catalytic "ribonucleic-protein complexes" became known as ... Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 ... ribonucleic-protein complexes that catalyse the assembly of amino acids into proteins according to the messenger RNA ... Many molecular biologists were puzzled by the problem of the origin of a protein replicating system that is as complex as that ...
The receptor is a heteromeric complex that interacts with multiple intracellular proteins by three different subunits: GluN1, ... adaptor, and scaffolding proteins. ... Proteins of the major histocompatibility complex class I are ... NMDA receptors are heterotetramers with two GluN1 subunits and two variable subunits. Two of these variable subunits, ... two obligatory GluN1 subunits and two regionally localized GluN2 subunits. A related gene family of GluN3 A and B subunits have ...
Protein nanopore sequencing utilizes membrane protein complexes such as α-hemolysin, MspA (Mycobacterium smegmatis Porin A) or ... MPSS was a bead-based method that used a complex approach of adapter ligation followed by adapter decoding, reading the ... "Use of automated sequencing of polymerase chain reaction-generated amplicons to identify three types of cholera toxin subunit ... a small protein secreted by the pancreas. This provided the first conclusive evidence that proteins were chemical entities with ...
... which is facilitated by binding to adaptor proteins via protein-protein interaction motifs that are collectively referred to as ... followed by cleavage into a small subunit and large subunit. The large and small subunit associate with each other to form an ... These proteins allow caspase-1 activation by forming a multiprotein activating complex called Inflammasomes. For example, a NOD ... The adaptor protein FADD will recruit (by a Death domain-Death domain interaction) pro-Caspase 8 via the DED domain. This FasR ...
Some of the proteins that associate with HATs in these complexes function by targeting the HAT complex to nucleosomes at ... They usually function within a multisubunit complex in which the other subunits are necessary for them to modify histone ... transcriptional adaptor), TFIID (transcription factor II D), TFTC (TBP-free TAF-containing complex), and NuA3/NuA4 (nucleosomal ... and it is the last protein to bind in the complex.. Histones tend to be positively charged proteins with N-terminal tails that ...
Lewis C. Cantley
... control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb". Curr. Biol. 13 (15): 1259-68. doi:10.1016 ... Specifically, they discovered that the catalytic subunit p110 dimerizes with the regulatory subunit p85, and that the SH2 ... on growth factor receptors or adaptor proteins via the pY-X-X-M motif. ... May 1993). "Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit". J. ...
IGFBP5 - ويكيبيديا
... binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. 273 (11): 6074-9 ... 1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107-13. PMID 8619474. doi ... insulin-like growth factor ternary complex. • منطقة خارج الخلية. • insulin-like growth factor binding protein complex. • ... "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain". J. ...
2bcj: Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... protein complex binding. • signal transducer activity. • protein binding. • GTPase activity. • GTPase binding. • G-protein ... Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene. ...
AZI2: encoding protein 5-azacytidine-induced protein 2. *BRK1: SCAR/WAVE actin nucleating complex subunit ... TRAT1: T-cell receptor-associated transmembrane adapter 1. *USH3A: Usher syndrome 3A ... C3orf14-Chromosome 3 open reading frame 14: predicted DNA binding protein.. *C3orf23: encoding protein Uncharacterized protein ... FRA3A encoding protein Fragile site, aphidicolin type, common, fra(3)(p24.2). *FRMD4B encoding protein FERM domain containing ...
ARF1 - ويكيبيديا
"ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein ... regulation of Arp2/3 complex-mediated actin nucleation. • positive regulation of late endosome to lysosome transport. • protein ... "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107-13. 1996. doi:10.1006/abio. ... "ADP-ribosylation factor is functionally and physically associated with the Golgi complex". Proc. Natl. Acad. Sci. U.S.A. 87 (3 ...
"Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the ... negative regulation of protein complex assembly. • epithelial-mesenchymal cell signaling. • actin filament branching. • ... Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein ... protein binding. • thioesterase binding. • protein kinase binding. • nucleotide binding. • GTP binding. • identical protein ...
AP2B1 - Wicipedia
... adaptor related protein complex 2 beta 1 subunit, adaptor related protein complex 2 subunit beta 1. ... dynol gan y genyn AP2B1 yw AP2B1 a elwir hefyd yn AP-2 complex subunit beta ac Adaptor related protein complex 2 beta 1 subunit ... clathrin adaptor complex. • AP-2 adaptor complex. • clathrin-coated endocytic vesicle. • postsynapse. • glutamatergic synapse. ... clathrin adaptor activity. • GO:0032403 macromolecular complex binding. • clathrin binding. • protein transporter activity. • ...
"Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined ... Seifert, R A; Hart C E; Phillips P E; Forstrom J W; Ross R; Murray M J; Bowen-Pope D F (May 1989). "Two different subunits ... "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". ... Receptor alfa-tipa iz trombocida izvedenog faktora rasta je protein koji je kod ljudi kodiran PDGFRA genom. ...
... a protein similar to the yeast proteins, Rvs167 and Rvs161". FEBS Letters. 351 (1): 73-9. doi:10.1016/0014-5793(94)00826-4. ... A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in muscle ... Micheva KD, Kay BK, McPherson PS (October 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions ... 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2". The Journal of Biological Chemistry. 276 (11): 8104-10. doi: ...
Alfa-1B adrenergički receptor - Википедија, слободна енциклопедија
Diviani D; Lattion AL; Abuin L (2003). „The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and ... signalni put G-protein spregnutog receptora. • G-proteinska signalizacija, spregnuta sa cAMP nukleotidnim sekundarnim glasnikom ... function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits ... Diviani D; Lattion AL; Abuin L (2003). „The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and ...
... subunits. In addition, the beta and gamma subunits can form a stable dimeric complex referred to as the beta-gamma complex. ... Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... Types of G protein signaling. G protein can refer to two distinct families of proteins. Heterotrimeric G proteins, ... Phosducin- transducin beta-gamma complex. Beta and gamma subunits of G-protein are shown by blue and red, respectively. ...
... assumption that there must exist an adapter molecule capable of mediating the translation of the RNA alphabet into the protein ... In the A/T site, the A-site half resides in the small ribosomal subunit where the mRNA decoding site is located. The mRNA ... During translation elongation, tRNA first binds to the ribosome as part of a complex with elongation factor Tu (EF-Tu) or its ... During protein synthesis, tRNAs with attached amino acids are delivered to the ribosome by proteins called elongation factors, ...
G protein-coupled receptor
The protein enzyme contains two catalytic subunits and two regulatory subunits. When there is no cAMP，the complex is inactive. ... it undergoes a conformational change allowing it to serve as a scaffolding protein for an adaptor complex termed AP-2, which in ... α subunit of the heterotrimeric G protein via protein domain dynamics. The activated Gα subunit exchanges GTP in place of GDP ... G protein subunits, lipids, anchoring proteins and calcium-sensitive proteins. ...
Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... Nitrosyl compounds: Metal nitrosyl complexes: Roussin's black salt. *Roussin's red salt. *Sodium nitroprusside (SNP) ... Guanylyl cyclase activator (protein). References. *^ Sakurai K.; Chen J.; Kefalov V. (2011). "Role of guanylate cylcase ... Guanylate cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and ...
Ribosomes: The ribosome is a large complex of RNA and protein molecules. They each consist of two subunits, and act as an ... The mRNA sequence directly relates to the polypeptide sequence by binding to transfer RNA (tRNA) adapter molecules in binding ... The subunit protein of microfilaments is a small, monomeric protein called actin. The subunit of microtubules is a dimeric ... Protein synthesis. Main article: Protein biosynthesis. Cells are capable of synthesizing new proteins, which are essential for ...
Cascade (CRISPR-associated complex for antiviral defense). CRISPR Cascade protein (cyan) bound to CRISPR RNA (green) and viral ... Subunit of the interference module. Important in targeting of invading DNA by recognizing the PAM sequence. . ... The cas genes in the adaptor and effector modules of the CRISPR-Cas system are believed to have evolved from two different ... In the I-E system of E. coli Cas1 and Cas2 form a complex where a Cas2 dimer bridges two Cas1 dimers. In this complex Cas2 ...
AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo sapiens (human)] - Gene - NCBI
adapter-related protein complex 5 mu subunit. adapter-related protein complex 5 subunit mu-1. adaptor related protein complex 5 ... AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo sapiens] AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo ... AP-5 complex subunit mu-1. Names. AP-5 complex subunit mu. MHD domain-containing death-inducing protein. MU-2/AP1M2 domain ... adaptor related protein complex 5 subunit mu 1provided by HGNC. Primary source. HGNC:HGNC:20192 See related. Ensembl: ...
AP2B1 adaptor related protein complex 2 subunit beta 1 [Homo sapiens (human)] - Gene - NCBI
adaptor protein complex AP-2 subunit beta. adaptor related protein complex 2 beta 1 subunit. adaptor-related protein complex 2 ... AP-2 complex subunit beta. Names. adapter-related protein complex 2 beta subunit. adapter-related protein complex 2 subunit ... AP2B1 adaptor related protein complex 2 subunit beta 1 [Homo sapiens] AP2B1 adaptor related protein complex 2 subunit beta 1 [ ... adaptor related protein complex 2 subunit beta 1provided by HGNC. Primary source. HGNC:HGNC:563 See related. Ensembl: ...
adaptor related protein complex 3 subunit mu 1 ELISA Kits | Biocompare
Compare adaptor related protein complex 3 subunit mu 1 ELISA Kits from leading suppliers on Biocompare. View specifications, ... adaptor related protein complex 3 subunit mu 1 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used ... Your search returned 14 adaptor related protein complex 3 subunit mu 1 ELISA ELISA Kit across 2 suppliers. ... Watch Webinar: How To Get Speed and Depth in your Host Cell Protein (HCP) Analysis ...
AP4S1 (adaptor related protein complex 4 sigma 1 subunit)
... adaptor related protein complex 4 sigma 1 subunit), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... AP4S1 (adaptor related protein complex 4 sigma 1 subunit). Identity. Alias_names. adaptor-related protein complex 4, sigma 1 ... transporter activity clathrin-coated pit protein transporter activity protein transport endosome lumen trans-Golgi network ... transporter activity clathrin-coated pit protein transporter activity protein transport endosome lumen trans-Golgi network ...
Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) Antibodies
... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... anti-Adaptor-Related Protein Complex 2, beta 1 Subunit Antibodies * anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit ... anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit Antibodies * anti-Adaptor-Related Protein Complex 1, sigma 3 Subunit ... anti-Adaptor-Related Protein Complex 1, sigma 2 Subunit Antibodies * anti-Adaptor-Related Protein Complex 1, mu 2 Subunit ...
RCSB PDB - 3L81: Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting...
... mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP) ... Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the ... Sorting of the Alzheimers disease amyloid precursor protein mediated by the AP-4 complex.. Burgos, P.V., Mardones, G.A., Rojas ... Adaptor protein 4 (AP-4) is the most recently discovered and least well-characterized member of the family of heterotetrameric ...
Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits
... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... adaptor related protein complex 2 mu 1 subunit (AP2M1) Elisa Kit * adaptor-related protein complex 2, mu 1 subunit, a (ap2m1a) ... adaptor-related protein complex 2, mu 1 subunit (Ap2m1) Elisa Kit * adaptor related protein complex 2 mu 1 subunit L homeolog ( ... Adaptor-Related Protein Complex 1, beta 1 Subunit ELISA Kits * Adaptor-Related Protein Complex 1 Associated Regulatory Protein ...
Adaptor protein complex AP-2 subunit mu | definition of Adaptor protein complex AP-2 subunit mu by Medical dictionary
Adaptor protein complex AP-2 subunit mu explanation free. What is Adaptor protein complex AP-2 subunit mu? Meaning of Adaptor ... protein complex AP-2 subunit mu medical term. What does Adaptor protein complex AP-2 subunit mu mean? ... Looking for online definition of Adaptor protein complex AP-2 subunit mu in the Medical Dictionary? ... Adaptor protein complex AP-2 subunit mu , definition of Adaptor protein complex AP-2 subunit mu by Medical dictionary https:// ...
Maus Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) Protein (His tag), Recombinant | ABIN3129522
... sigma 2 Subunit (AP1S2) Protein (His tag). Spezies: Maus. Quelle: Escherichia coli (E. coli). Jetzt Produkt ABIN3129522 ... Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) Hintergrund. Subunit of clathrin-associated adaptor protein complex ... Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) (AA 1-160) protein (His tag) Protein AP1S2 Spezies: Maus Quelle: ... Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) (AA 1-157) protein (His tag) Protein ...
Adapter-related protein complex 3 subunit beta-1 | definition of Adapter-related protein complex 3 subunit beta-1 by Medical...
What is Adapter-related protein complex 3 subunit beta-1? Meaning of Adapter-related protein complex 3 subunit beta-1 medical ... What does Adapter-related protein complex 3 subunit beta-1 mean? ... Looking for online definition of Adapter-related protein ... complex 3 subunit beta-1 in the Medical Dictionary? Adapter-related protein complex 3 subunit beta-1 explanation free. ... Adapter-related protein complex 3 subunit beta-1 , definition of Adapter-related protein complex 3 subunit beta-1 by Medical ...
AP2S1 (adaptor-related protein complex 2, sigma 1 subunit) - KOMP (Knockout Mouse Project)
AP2A2 (adaptor-related protein complex 2, alpha 2 subunit) - KOMP (Knockout Mouse Project)
Role of the adaptor protein CIKS in the activation of the IKK complex
... able to bind the regulatory sub-unit NEMO/IKKgamma and to activate NF-kappaB. Here, we demonstrate that CIKS forms homo- ... Role of the adaptor protein CIKS in the activation of the IKK complex Biochem Biophys Res Commun. 2003 Sep 12;309(1):84-90. doi ... We found that the ability of CIKS to oligomerize, and to be recruited to the IKK-complex is not sufficient to activate the NF- ... and to be recruited to the IKK-complex does not activate NF-kappaB, suggesting that CIKS needs a second level of regulation to ...
ap3s2 Protein, adaptor-related protein complex 3, sigma 2 subunit - Creative BioMart
Creative Biomart offer ap3s2 proteins for life sciences research. All the products are rigorously tested to meet the most ... AP3S2;adaptor-related protein complex 3, sigma 2 subunit;AP-3 complex subunit sigma-2;sigma3b;sigma-3B-adaptin;sigma-adaptin 3b ... adaptor complex sigma3B;AP-3 complex subunit sigma-3B;clathrin-associated/assembly/adaptor protein, small 4, 22-kD;AP3S3; ... Protein Function. AP3S2 has several biochemical functions, for example, protein transporter activity. Some of the functions are ...
Ap1g1 - adaptor protein complex AP-1, gamma 1 subunit | International Mouse Phenotyping Consortium
The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit mu1A via a novel basic binding motif...
RCSB PDB - Gene View - AP3D1 - adaptor related protein complex 3 delta 1 subunit
... and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon ... The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, ... White boxes represent UTRs (untranslated regions). Orange: protein coding regions. The black lines connecting boxes represent ... Previous Names: "adaptor-related protein complex 3, delta 1 subunit" HgncId : HGNC:568 Omim: 607246 ...
AP4B1 gene - Genetics Home Reference - NIH
AP5Z1 gene - Genetics Home Reference - NIH
AP4M1 Gene - GeneCards | AP4M1 Protein | AP4M1 Antibody
Protein Coding), Adaptor Related Protein Complex 4 Mu 1 Subunit, including: function, proteins, disorders, pathways, orthologs ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ... The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition ...
AP2A2 Gene - GeneCards | AP2A2 Protein | AP2A2 Antibody
Protein Coding), Adaptor Related Protein Complex 2 Alpha 2 Subunit, including: function, proteins, disorders, pathways, ... Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport ... Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport ... The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and ...
Hereditary neutropenia: dogs explain human neutrophil elastase mutations
The recent finding that mutation of AP3B1, which encodes the beta subunit of adaptor protein complex 3 (AP3), is the cause of ... AP3 recognizes NE as a cargo protein, and their interaction implies that NE is a transmembrane protein. Computerized algorithms ... AP3B1 protein, human * Adaptor Protein Complex 3 * Adaptor Protein Complex beta Subunits ...
Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. ...
AP1S2 encodes an adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of coated ... Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations ... AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles. ... The complex mediates the recruitment of clathrin to the vesicle membrane. ...
AP1M2 gene and Anti-AP1M2 human mouse, AP1-mu2, HSMU1B, MU-1B, MU1B, mu2 | adaptor related protein complex 1 subunit mu 2...
... adaptor protein complex AP-1 mu-2 subunit,adaptor related protein complex 1 mu 2 subunit,clathrin assembly protein complex 1 mu ... AP1M2: adaptor related protein complex 1 subunit mu 2. AP1-mu2, HSMU1B, MU-1B, MU1B, mu2. Summary. This gene encodes a subunit ... clathrin-associated adaptor medium chain mu2,golgi adaptor AP-1 47 kDa protein,golgi adaptor HA1/AP1 adaptin mu-2 subunit,mu- ... of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family ...
A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a...
Adaptor-related protein complex 2 alpha 2 subunit (AP2A2) gene encodes a protein-a subunit of the AP-2 adaptor protein complex ... A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a ... Adaptor Protein Complex 2. *Adaptor Protein Complex alpha Subunits. *adaptor protein complex 2, alpha 2 subunit ... Evidence has revealed that benzodiazepine receptor-associated protein 1 (BZRAP1) is abundant in the hippocampus with potential ...
603401 ADAPTOR-RELATED PROTEIN COMPLEX 3, BETA-1 SUBUNIT; AP3B1. 608233 HERMANSKY-PUDLAK SYNDROME 2; HPS2. ... Nonsense mutations in ADTB3A cause complete deficiency of the beta3A subunit of adaptor complex-3 and severe Hermansky-Pudlak ... 603401 ADAPTOR-RELATED PROTEIN COMPLEX 3, BETA-1 SUBUNIT; AP3B1. 608233 HERMANSKY-PUDLAK SYNDROME 2; HPS2. ...
List of adaptins - Wikipedia
Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a ... 2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. PMC 3191125. PMID ... Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". Journal ...
Notch Signaling | www.antibodies-online.com
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP ... FBXW7 Proteins NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase): NEDD4 ... DLL3 (delta Like Protein 3): DLL3 antibodies DLL3 ELISA Kits DLL3 Proteins ... POFUT1 (Protein O-Fucosyltransferase 1): POFUT1 antibodies POFUT1 ELISA Kits POFUT1 Proteins ...
AP2M1 - AP-2 complex subunit mu - Homo sapiens (Human) - AP2M1 gene & protein
Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor ... Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and ... The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting ... protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is ...
Ap2b1 - AP-2 complex subunit beta - Mus musculus (Mouse) - Ap2b1 gene & protein
Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor ... Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and ... The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at ... protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is ...
EncodesSigmaGolgiIntracellularPhosphorylationPlasma membrane adaptorEndocytosisCargoAlpha subunitGenesCatalytic subunitDelta subunitHomoCytoplasmBinds polyphosphoinositide-contaiLipidsAccessory proteinsFifth adaptor proteinAP2M1KinasePutativeInteractRegulatory subunitsMRNASequenceUniProtVesicular transportInteractionTransmembrane proteinsAP4M1Appendage domainRecombinant proteinsInteractionsPathwaysHeterotrimericApoptosisHighly conservedRecruit clathrinCellularUbiquitin ProteiMutationMoleculesPathwayBelongsForm complexesReceptorsMediatesAssemblyAdaptin subunitAnaphase-promoting complexELISA KitsAntigens
- This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. (antikoerper-online.de)
- A gene on chromosome 5q14.1 that encodes a subunit of the heterotetrameric AP3 complex, a protein complex composed of two large subunits (delta and beta), a medium subunit (mu), and a small subunit (sigma). (thefreedictionary.com)
- This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. (nih.gov)
- This gene encodes a subunit of the heterotetrameric AP-4 complex. (genecards.org)
- AP1S2 encodes an adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of coated vesicles located at the Golgi complex. (ox.ac.uk)
- AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles. (ox.ac.uk)
- Adaptor-related protein complex 2 alpha 2 subunit (AP2A2) gene encodes a protein-a subunit of the AP-2 adaptor protein complex. (cdc.gov)
- This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. (antibodies-online.com)
- This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. (antibodies-online.com)
- This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. (antibodies-online.com)
- 2 It encodes a 24-kDa protein, termed retinoschisin, which is mainly secreted from photoreceptors as a homo-oligomeric complex. (arvojournals.org)
- 7. The expression vector according to claim 5, wherein the recombinant nucleic acid according to claim 1 further comprises a protein coding sequence that encodes a reporter protein or a therapeutic protein. (freepatentsonline.com)
- This gene encodes the small chain of this complex. (abnova.com)
- This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. (origene.com)
- The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). (genecards.org)
- Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. (ox.ac.uk)
- The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). (antibodies-online.com)
- An important gene associated with Dandy-Walker Malformation with Intellectual Disability, Basal Ganglia Disease and Seizures is AP1S2 (Adaptor Related Protein Complex 1 Subunit Sigma 2). (malacards.org)
- Adaptor protein 4 (AP-4) is the most recently discovered and least well-characterized member of the family of heterotetrameric adaptor protein (AP) complexes that mediate sorting of transmembrane cargo in post-Golgi compartments. (rcsb.org)
- These findings demonstrate that APP and AP-4 engage in a distinct type of signal-adaptor interaction that mediates transport of APP from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. (rcsb.org)
- AP3 plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes, as well as in biogenesis of melanosomes, platelet dense granules and lysosomes. (thefreedictionary.com)
- AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (nih.gov)
- This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. (genecards.org)
- The complex is associated with the Golgi region as well as more peripheral structures. (fishersci.com)
- Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. (abcam.com)
- Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. (abcam.com)
- This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. (thermofisher.com)
- The GP precursor is post-translationally cleaved by the pro-protein convertase furin within the Golgi compartment of virus-producer cells, yielding two disulfide-linked subunits, GP1 and GP2 [ 13 ]. (mdpi.com)
- Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. (genetex.com)
- In the course of HCV protein production, there is disruption of the Golgi apparatus, loss of spatial organization of the ER, appearance of some "virus-like" structures and swelling of mitochondria. (biomedcentral.com)
- Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (uniprot.org)
- The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (uniprot.org)
- the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (uniprot.org)
- It may also play a role in regulating the intracellular trafficking and function of CTLA-4 protein. (thefreedictionary.com)
- Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. (antibodies-online.com)
- Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. (wikipedia.org)
- The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles. (thermofisher.com)
- Intracellular traffic of many membrane-bound proteins requires sequences facing the cytoplasm. (eu.org)
- HPS-2 disease results from mutations in the b3A subunit of a coat protein, adaptor complex-3, responsible for intracellular vesicle formation. (clinicaltrials.gov)
- Adaptors bind to signaling motifs on the intracellular side of the receptors. (rupress.org)
- After contact by Wnt/β-catenin positive filopodia, a multi-protein complex at the plasma membrane assembles clustering membrane-bound receptors and intracellular signal transducers into the so-called Lrp6-signalosome. (exeter.ac.uk)
- The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. (uniprot.org)
- G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. (duke.edu)
- These domains coordinate to bind AMP, ADP and ATP, allowing the AMPK γ -subunit to "regulate AMPK activation through allosteric structural changes in the catalytic α -subunits, modulating phosphorylation by upstream kinases and regulating the dephosphorylation of Thr 172 . (wikibooks.org)
- Furthermore, AMP allows for AMPK regulation because upon AMP's binding to the γ -subunit, it has been observed that the phosphorylation of Thr 172 by upstream kinases has been enhanced, while the dephosphorylation of Thr 172 by various protein phosphatases has been inhibited. (wikibooks.org)
- Downstream signals arise from Jak1/Jak3-mediated phosphorylation of tyrosine residues on IL-2Rβ, which creates docking sites for the adaptor protein Shc and the transcription factor STAT5 ( 6 , 7 , 8 , 9 , 10 , 11 ). (jimmunol.org)
- Exposure of human umbilical vein endothelial cells to hypoxia results in HIF protein stabilization as early as 10 minutes, with a maximum at 3 hours, and also in Shc tyrosine phosphorylation, with a maximum at 10 minutes. (ahajournals.org)
- In this model, we observed that HCV proteins control cellular translation through eIF-2α-S51 phosphorylation, with involvement of the double-stranded RNA-dependent protein kinase PKR. (biomedcentral.com)
- Despite this, all three complexes were activated, due to increased Thr 172 phosphorylation, when cells were incubated with mitochondrial inhibitors that increase cellular AMP. (portlandpress.com)
- However, effects of AMP or ADP on activation and phosphorylation of the γ2 and γ3 complexes were small or insignificant. (portlandpress.com)
- Reversible protein phosphorylation is a highly conserved, essential regulatory mechanism involved in a host of cellular processes. (mcponline.org)
- Purified Hct1 is phosphorylated in vitro at these sites by purified Cdc28-cyclin complexes, and phosphorylation abolishes the ability of Hct1 to activate the APC in vitro. (sdbonline.org)
Plasma membrane adaptor1
- AP50 is a subunit of the plasma membrane adaptor. (xenbase.org)
- Title: The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis. (nih.gov)
- We identify dynamin and the EAP -binding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in clathrin mediated endocytosis. (antikoerper-online.de)
- AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. (genecards.org)
- AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. (genecards.org)
- Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. (nih.gov)
- Accessory protein recruitment motifs in clathrin-mediated endocytosis. (eu.org)
- Both charasome degradation and constitutive endocytosis are also significantly inhibited by sterol complexing agents (methyl-ß-cyclodextrin and filipin). (frontiersin.org)
- Clathrin-dependent endocytosis is initiated at the plasma membrane with the recruitment of coat machinery and cargo proteins into clathrin-coated membrane invaginations the so called clathrin coated pits (CPs). (frontiersin.org)
- During the early stages of endocytosis three components-adaptor and accessory proteins, cargo, and lipids-come together at the plasma membrane to begin the formation of clathrin-coated vesicles. (rupress.org)
- Although the budding of clathrin-coated vesicles in vitro has recently been shown to only require the presence of clathrin, an adaptor protein, and dynamin ( Dannhauser and Ungewickell, 2012 ), endocytosis in vivo is a lot more complex. (rupress.org)
- When studying the initiation of endocytosis we need to focus on the earliest stages of the sequence of protein assembly. (rupress.org)
- A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. (nih.gov)
- Results indicate that AP-2 is not essential for clathrin -coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins. (antikoerper-online.de)
- Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. (nih.gov)
- Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. (genecards.org)
- The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin 2 are evolutionarily conserved from worm to man, thereby identifying stonin 2 and its invertebrate homologs uncoordinated (UNC)-41 and stoned B as endocytic adaptors dedicated to the retrieval of surface-stranded SV proteins, most notably synaptotagmin. (nih.gov)
- The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (abcam.com)
- To recruit cargo, a number of adaptor proteins are needed. (pubmedcentralcanada.ca)
- It is not a conventional adaptor protein in that it does not link cargo into the clathrin cage. (pubmedcentralcanada.ca)
- Cargo sorting is essential for plant survival and therefore necessitates complex molecular machinery. (plantphysiol.org)
- Generally, vesicle formation requires a conserved set of coat proteins that bind to cargo and induce membrane curvature. (biologists.org)
- AP-3 is an "adaptor protein complex," a group of four proteins known to sort cargo proteins to specific compartments in the cell. (innovations-report.com)
- Both pathways can be classified according to their cargo, as well as the proteins and lipids involved in vesicle production and trafficking. (frontiersin.org)
- The key players involved in these stages are clathrin adaptors and accessory proteins, cargo, and lipids ( Fig. 2 ). (rupress.org)
- Adaptor proteins, cargo, lipids, and clathrin accumulate at the plasma membrane to make up the nascent endocytic site. (rupress.org)
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (nih.gov)
- RESULTS- Due to linkage disequilibrium, we were unable to distinguish between rs2476601/Trp 620 ( P = 2.11 ×10 −87 ) and rs6679677 ( P = 3.21 ×10 −87 ), an intergenic SNP between the genes putative homeodomain transcription factor 1 and round spermatid basic protein 1. (diabetesjournals.org)
- With the recent capability to scan hundreds of thousands of single nucleotide polymorphisms (SNPs) across the genome in thousands of samples, the identification of complex disease genes and regions has greatly been enhanced ( 12 ). (diabetesjournals.org)
- Simultaneous assessment of the expression of thousands of genes in a single experiment could allow better understanding of the complex and heterogeneous molecular properties of breast cancer. (biomedcentral.com)
- The levels of C - reactive protein were higher in hypertensive patients than normotensives and inflammation-related genes were increased as well. (medsci.org)
- Essential hypertension has been recognized as a complex, multifactorial, polygenic trait which involves multiple modulating genes and environmental factors. (medsci.org)
- There are multiple isoforms of each subunit, which are encoded by specific genes that are distributed across several chromosomes. (wikibooks.org)
- in humans, all three subunits are encoded by multiple genes, i.e. (portlandpress.com)
- PP2A often functions as a standard trimeric complex with a catalytic (C) subunit (encoded by two genes in mammals) associated with one of many regulatory (or B) subunits via one of two adaptor (A) molecules ( 4 , 5 ). (mcponline.org)
- We further find that Eda-activated RelB recruits BAF complex to specific gene loci for local chromatin remodeling of target genes. (pnas.org)
- Notably, RelB and the BAF complex are indispensable for transcription of Eda target genes, and both BAF complex and Eda signaling are required to open chromatin of Eda targets. (pnas.org)
- We have previously identified mutant alleles of genes encoding two Rab proteins, Ypt3 and Ryh1, through a genetic screen using the immunosuppressant drug FK506 in fission yeast. (genetics.org)
- Mammalian AMPK is a "heterotrimeric complex comprised of a catalytic subunit ( α -subunit) and two regulatory subunits ( β - and γ - subunits). (wikibooks.org)
- The authors have recently described an interaction between Gag and the delta subunit of the AP-3 adaptor protein complex (1). (indigo.ca)
- They identified several known and novel interacting proteins and selected one, the delta subunit of AP-3, for further evaluation. (innovations-report.com)
- Through a series of experiments, the group demonstrated that the AP-3 delta subunit interacts with Gag to direct it to the multivesicular body. (innovations-report.com)
- Here, we demonstrate that CIKS forms homo-oligomers, interacts with NEMO/IKKgamma, and is recruited to the IKK-complex upon cell stimulation. (nih.gov)
- Gag is a myristoylated precursor protein that is translated in the cytoplasm and then traffics to the plasma membrane or to endosomal vesicles for assembly. (indigo.ca)
- AP4M1 antibody [N1C1] detects AP4M1 protein at cytoplasm in mouse testis by immunohistochemical analysis. (genetex.com)
- instead, it is regulated by "relocation from the nucleus to the cytoplasm upon binding to STRAD (Ste20-related adaptor) and MO25 (mouse protein 25). (wikibooks.org)
- As determined by confocal microscopy, HCV proteins expressed from VT7-HCV7.9 localize largely in a globular-like distribution pattern in the cytoplasm, with some proteins co-localizing with the endoplasmic reticulum (ER) and mitochondria. (biomedcentral.com)
- AP2 and accessory proteins recruit clathrin subunits directly from the cytoplasm to the nucleation site. (frontiersin.org)
- The complex binds polyphosphoinositide-containing lipids. (xenbase.org)
- This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. (genecards.org)
- Exchange of lipids, metabolites or proteins across the lipid bilayer can occur through integral membrane proteins - as demonstrated for peroxisomes, mitochondria or chloroplasts. (biologists.org)
- Each AP also contains two large homologous subunits (γ + β1 in the AP1 complex, α + β2 in the AP2 complex, and δ + β3 in the AP3 complex) whose appendage domains bind to core and accessory proteins necessary for clathrin-coated vesicle (CCV) formation. (pubmedcentralcanada.ca)
Fifth adaptor protein2
- 171 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) Antibodies from 23 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
- Auf www.antikoerper-online.de finden Sie aktuell 17 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits von 5 unterschiedlichen Herstellern. (antikoerper-online.de)
- Recombinant protein fragment corresponding to amino acids 97-383 of human AP2M1 (NP_001020376) produced in E.coli. (novusbio.com)
- Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. (duke.edu)
- G protein-coupled receptor kinase 2 (GRK2) phosphorylates activated G protein-coupled receptors (GPCRs), which ultimately leads to their desensitization and/or downregulation. (duke.edu)
- We hypothesized that the MC159 protein targeted the IκB kinase (IKK) complex to inhibit these diverse signaling events. (jimmunol.org)
- The formed signalsome then recruits and activates the IκB kinase (IKK) complex, a convergence point for canonical activators of NF-κB ( 15 ). (jimmunol.org)
- AMP-activated protein kinase, or AMPK, is a well-known energy sensor, capable of regulating pathways in order to increase the amount of ATP in the cell. (wikibooks.org)
- Two upstream kinases of AMPK include liver kinase B1 (LKB1) and Ca 2+ /calmodulin-dependent protein kinase kinase β (CaMKK β ). (wikibooks.org)
- PIP 3 recruits to the cell membrane proteins containing pleckstrin homology domains, such as 3-phosphoinositide-dependent kinase 1 (PDK1) and Akt. (jimmunol.org)
- Moreover, cells pretreated with a specific Raf-1 kinase inhibitor, a known downstream effector of Ras, exhibited reduced HIF protein levels. (ahajournals.org)
- AMP-activated protein kinase (AMPK) is expressed ubiquitously and is activated by increases in AMP and/or ADP relative to ATP, thus acting as a sensor of cellular energy status [ 1 - 3 ]. (portlandpress.com)
- AMPK complexes are activated by upstream kinases that phosphorylate a conserved threonine residue (Thr 172 in rat α2 [ 9 ]) within the activation loop of the α subunit kinase domain. (portlandpress.com)
- Work from a variety of labs has determined that the activity of Chk1 inhibits the Cdc25 phosphatase and activates the Wee1 and Mik1 protein kinases, two actions that favor phosphorylated, and thus inactive, cyclin-dependent kinase, the engine that drives the cell cycle. (biomedcentral.com)
- The von Hippel-Lindau tumor suppressor protein, a putative ubiquitin-protein ligase, 11 appears to play a role in HIF protein stabilization, inasmuch as loss of the von Hippel-Lindau protein results in constitutive expression of the HIF protein. (ahajournals.org)
- In this paper we present a new approach for the detection of putative protein interactions based on expression data. (biomedcentral.com)
- In fact, a deletion mutant of CIKS able to oligomerize, to interact with NEMO/IKKgamma, and to be recruited to the IKK-complex does not activate NF-kappaB, suggesting that CIKS needs a second level of regulation to efficiently activate NF-kappaB. (nih.gov)
- Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, l. (xenbase.org)
- Structural studies are revealing the mechanisms by which SNARES form complexes and interact with other proteins. (biologists.org)
- The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins [ PMID: 15688063 , PMID: 11961546 , PMID: 15537541 ]. (ebi.ac.uk)
- The adaptors interact with the plasma membrane via lipid-binding domains, many of which bind specifically to PIP 2 . (rupress.org)
- As it is very difficult to determine the specific impact of individual parameters in a complex biological system by a purely experimental approach, we interact with mathematicians using computational modelling. (exeter.ac.uk)
- Ref. 2 ) based on sequence homology, associated regulatory subunits, sensitivity to different types of chemical inhibitors, and metal ion requirements. (mcponline.org)
- and 9 ), but whether these proteins represent bona fide regulatory subunits or phosphatase substrates and how these binding proteins may affect PP4 activity are unclear. (mcponline.org)
- Expression of a novel beta adaptin subunit mRNA splice variant in human testes. (nih.gov)
- Herein, we report the interaction of an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP) with the mu4 subunit of AP-4. (rcsb.org)
- Biochemical and X-ray crystallographic analyses reveal that the properties of the APP sequence and the location of the binding site on mu4 are distinct from those of other signal-adaptor interactions. (rcsb.org)
- Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin. (wikipedia.org)
- Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
- 8. An isolated host cell comprising the expression vector of claim 5 wherein the expression vector of claim 5 comprises a protein coding sequence, and the host cell transiently or encoded in the expression vector of claim 5. (freepatentsonline.com)
- 9. An isolated host cell which is obtained by in vivo injection of the expression vector of claim 5 into a cell, wherein the expression vector of claim 5 comprises a protein coding sequence, and the host cell comprises the expression vector of claim 5 and transiently or encoded in the expression vector of claim 5. (freepatentsonline.com)
- Recombinant protein encompassing a sequence within the center region of human AP4M1. (genetex.com)
- Analysis of Chara australis clathrin proteins revealed two heavy chains and several light chains with sequence peculiarities, suggesting functional and/or species specific differences. (frontiersin.org)
- p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
- Overview of all the structural information available in the PDB for UniProt: O00189 (Human AP-4 complex subunit mu-1) at the PDBe-KB. (wikipedia.org)
- They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). (nih.gov)
- They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). (genecards.org)
- The enzyme is recruited to the plasma membrane via the interaction of its carboxyl-terminal pleckstrin-homology (PH) domain with the beta and gamma subunits of heterotrimeric G proteins (Gbetagamma). (duke.edu)
- We show that the AP-1 complex facilitates retroviral budding through a direct interaction between the matrix and AP-1mu. (cnrs.fr)
- Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit. (eu.org)
- The C-terminal domain allows for the interaction with the β - and γ -subunits. (wikibooks.org)
- These events are mediated by a variety of hypoxia-sensitive cellular proteins, which modulate cell-cell interaction and cell proliferation and differentiation. (ahajournals.org)
- Disruption of the interaction, using a specific piece of the AP-3 subunit, eliminated Gag trafficking to the multivesicular body and diminished HIV particle formation in cells. (innovations-report.com)
- Therefore, we focused on tracking interactions within protein complexes, even though our algorithm can, in principle, identify any type of protein-protein interaction. (biomedcentral.com)
- The highly-conserved Notch signaling pathway is unique, as both the Notch receptor and most of its respective ligands (canonically the DSL or Delta/Serrate/lag-2 family members) are transmembrane proteins attached to the cell surface. (antibodies-online.com)
- AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. (abcam.com)
- IL-2 initiates a program of lymphocyte proliferation by binding IL-2R, which consists of three transmembrane proteins, IL-2Rα, IL-2Rβ, and γ c ( 4 ). (jimmunol.org)
- AP4M1 (Adaptor Related Protein Complex 4 Mu 1 Subunit) is a Protein Coding gene. (genecards.org)
- Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). (genecards.org)
- AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene. (wikipedia.org)
- EpsinR is a clathrin-coated vesicle (CCV) enriched 70-kD protein that binds to phosphatidylinositol-4-phosphate, clathrin, and the gamma appendage domain of the adaptor protein complex 1 (AP1). (pubmedcentralcanada.ca)
- The concentration of our recombinant proteins is measured using the absorbance at 280nm. (antikoerper-online.de)
- V1H can function as an adaptor for interactions between Nef and AP-2 (zeige GTF3A ELISA Kits ). (antikoerper-online.de)
- AP3S2 has direct interactions with proteins and molecules. (creativebiomart.net)
- The true physiological role(s) of p32 remains controversial because it has been difficult to reconcile all of the findings on protein interactions and the seemingly disparate observations on compartmentalisation. (biomedsearch.com)
- Interactions of viral protein U (Vpu) with cellular factors. (indigo.ca)
- Imaging of HIV/host protein interactions. (indigo.ca)
- Vpr and its interactions with cellular proteins. (indigo.ca)
- Furthermore, it is now apparent that the SNARE transmembrane segment not only anchors the protein but engages in SNARE-SNARE interactions and plays an active role in fusion. (biologists.org)
- The domain located at the C-terminus allows for stabilization of the interactions between the other two AMPK subunits, while the domain at the N-terminus targets AMPK to glycogen. (wikibooks.org)
- RGS9-2 acts via a complex mechanism that involves interactions with Gα subunits, the Gβ5 protein, and the adaptor protein R7BP. (sigmaaldrich.com)
- For human cells, published experimental results are collected in databases like MINT (Molecular Interactions database) and HPRD (Human Protein Reference Database) [ 8 , 9 ], but the amount of information is still largely limited. (biomedcentral.com)
- Moreover, data have been obtained from different cellular models and using different techniques, thus rendering it difficult to build a global network of interactions or to extrapolate information about the composition of multi-protein complexes. (biomedcentral.com)
- Besides the identification of permanent complexes, it is also capable (at least for well synchronized samples) of reliably identifying interactions among proteins belonging to transient complexes. (biomedcentral.com)
- Firstly, protein-protein interactions are more easily identified if the interacting protein pair belongs to a multi-protein complex. (biomedcentral.com)
- Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. (genecards.org)
- During this process, PI3Kγ is activated by ligands of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs), in particular adenosine receptors, through autocrine and paracrine pathways. (sciencemag.org)
- The Yxxphi motif is a sorting signal found in the cytosolic tail of various membrane proteins as an endocytic motif and also directs traffic within the endosomal and the secretory pathways. (eu.org)
- IL-2R activates two distinct signaling pathways mediated by the adaptor protein Shc and the transcription factor STAT5. (jimmunol.org)
- In mammals, Rabs define a family of almost 70 proteins that play critical roles in the trafficking of vesicles that mediate transport between compartments of the exocytic and endocytic pathways ( P feffer 2001 , 2005 ). (genetics.org)
- The γ subunits of heterotrimeric AMPK complexes contain the binding sites for the regulatory adenine nucleotides AMP, ADP and ATP. (portlandpress.com)
- For example, the MCV MC159 protein inhibits TNF-R1-induced NF-κB activation and apoptosis. (jimmunol.org)
- Biochemical analysis demonstrate that HCV proteins bring about the activation of initiator and effector caspases followed by severe apoptosis and mitochondria dysfunction, hallmarks of HCV cell injury. (biomedcentral.com)
- Insulin-like growth factor binding protein-3 (IGFBP-3) is known to induce apoptosis in an insulin-like growth factor (IGF)-dependent and IGF-independent manner, but the mechanism underlying the IGF-independent effects remains unclear. (ias.ac.in)
- 3 4 5 6 7 Retinoschisin is almost entirely composed of a highly conserved discoidin domain frequently found in a wide range of membrane and extracellular proteins and most likely mediating cell adhesion and cellular signaling processes. (arvojournals.org)
- Within the much larger PPP class, a common catalytic domain (of 280 aa) is highly conserved, whereas the N and C termini are more divergent and further separate the PPP proteins into subfamilies. (mcponline.org)
- On the one hand, the highly conserved adaptor protein complex 2 (AP2) is described as a central player in the initiation of CP nucleation. (frontiersin.org)
- The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration dependent manner. (exeter.ac.uk)
- The tails of adaptor proteins bind and recruit clathrin triskelions to the plasma membrane where they polymerize to form the clathrin coat. (rupress.org)
- Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (nih.gov)
- p32/gC1qR is a small acidic protein that has been reported to have a broad range of distinct functions and to associate with a wide array of cellular, viral and bacterial proteins. (biomedsearch.com)
- In addition, we find that AP-1 interacts with Tsg101 and Nedd4.1, two cellular proteins known to be involved in HIV-1 and MLV budding. (cnrs.fr)
- Proteolysis of mitotic cyclins depends on a multisubunit ubiquitin-protein ligase, the anaphase promoting complex (APC). (sdbonline.org)
- Notably, overexpression of spo20 + , encoding a phosphatidylcholine/phosphatidylinositol transfer protein, rescued gdi1-i11 mutation, but not ypt3-i5 or ryh1-i6 . (genetics.org)
- Also, other proteins which involved in the same pathway with AP3S2 were listed below. (creativebiomart.net)
- Knockdown of Rbp1 caused a similar microcephaly phenotype as the depletion of Nosip and synergy experiments indicated that both proteins act in the same signalling pathway. (xenbase.org)
- Upon stimulation of the NF-κB pathway, IKK becomes activated and phosphorylates an IκB protein ( 13 , 14 ). (jimmunol.org)
- Shc activates the PI3K pathway by recruiting the adaptor protein Grb2, which in turn recruits the adaptor protein Gab2 followed by the p85 PI3K-regulatory subunit ( 14 , 15 , 16 ). (jimmunol.org)
- The encoded protein belongs to the adaptor complexes medium subunits family. (genecards.org)
- The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. (antibodies-online.com)
- AP3S1 belongs to the adaptor complexes 3 (AP3) small subunit family which is not clathrin-associated. (fishersci.com)
- Belongs to the adaptor complexes large subunit family. (abcam.com)
- The protein encoded by this gene belongs to the SECY/SEC61- alpha family. (origene.com)
- Saccharomyces cerevisiae Cin8p belongs to the BimC family of kinesin-related motor proteins that are essential for spindle assembly. (sdbonline.org)
- All 12 possible combinations of subunits can form complexes when co-expressed [ 7 ], although certain combinations appear to be favoured in specific tissues [ 8 ]. (portlandpress.com)
- The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. (nih.gov)
- The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. (antibodies-online.com)
- Component of the adaptor complexes which link clathrin to receptors in coated vesicles. (xenbase.org)
- Thus, vesicle formation requires the uptake of targeting and fusion factors, including Rab-GTPases, tethering factors and SNAREs [soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors]. (biologists.org)
- Recognition of antigen by the B cell antigen receptor (BCR) is the main event in the B cell immune response and signaling through the BCR complex is tightly regulated by several different co-receptors. (frontiersin.org)
- The complex mediates the recruitment of clathrin to the vesicle membrane. (ox.ac.uk)
- The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. (abcam.com)
- To test whether Shc directly mediates hypoxia-induced HIF stabilization, human umbilical vein endothelial cells were transfected with a dominant-negative Shc mutant (dnShc), resulting in significantly reduced HIF protein levels compared with control. (ahajournals.org)
- The Vpu protein of HIV assists the virus assembly process through a poorly-defined mechanism. (indigo.ca)
- Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. (ebi.ac.uk)
- For several years, Paul W. Spearman, M.D., associate professor of Pediatrics and Microbiology & Immunology, and colleagues have been studying the assembly of HIV particles, specifically the distinct steps HIV structural proteins take in order to come together and create a viral particle. (innovations-report.com)
- Although many studies have demonstrated that Gag is present in the late endosome and have focused on particle assembly at that point, none have tackled how the Gag protein gets there in the first place. (innovations-report.com)
- This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. (genetex.com)
- Ubiquitin-mediated proteolysis due to the anaphase-promoting complex/cyclosome is essential for separation of sister chromatids, requiring degradation of the anaphase inhibitor Pds1, and for exit from mitosis, requiring inactivation of cyclin B Cdk1 kinases. (sdbonline.org)
- Progression through mitosis is controlled by protein degradation that is mediated by the anaphase-promoting complex/cyclosome and its associated specificity factors. (sdbonline.org)
- Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
- BMCC1 (zeige PRUNE2 ELISA Kits ) is an AP-2 (zeige GTF3A ELISA Kits ) associated endosomal protein in prostate cancer cells. (antikoerper-online.de)
- Arkadia (zeige RNF111 ELISA Kits ) complexes with clathrin adaptor AP2 (zeige GTF3A ELISA Kits ) mu2 subunit and regulates EGF (zeige EGF ELISA Kits ) signalling. (antikoerper-online.de)
- The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting and quantifying proteins and antigens from various samples. (biocompare.com)