Adaptor protein complex sigma subunits. Medical search

A family of small adaptin protein complex subunits of approximately 19 KDa in size.

An adaptor protein complex found primarily on perinuclear compartments.

A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.

A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.

An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.

Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).

An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.

The subunits that make up the large, medium and small chains of adaptor proteins.

A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.

A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.

A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.

A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.

A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.

A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.

A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes

Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research into the mapping of the human genome and other organism genomes. The National Center for Human Genome Research was established in 1989 and re-named the National Human Genome Research Institute in 1997.

NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.

Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.

A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane.

A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.

A class of genetic disorders resulting in INTELLECTUAL DISABILITY that is associated either with mutations of GENES located on the X CHROMOSOME or aberrations in the structure of the X chromosome (SEX CHROMOSOME ABERRATIONS).

Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)

The human female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in humans.

The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.

Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.

Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.

Specialized cells in the invertebrates that detect and transduce light. They are predominantly rhabdomeric with an array of photosensitive microvilli. Illumination depolarizes invertebrate photoreceptors by stimulating Na+ influx across the plasma membrane.

Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

Syndrome characterized by the triad of oculocutaneous albinism (ALBINISM, OCULOCUTANEOUS); PLATELET STORAGE POOL DEFICIENCY; and lysosomal accumulation of ceroid lipofuscin.

Melanin-containing organelles found in melanocytes and melanophores.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.

The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

A heat stable DNA-DIRECTED DNA POLYMERASE from the bacteria Thermus aquaticus. It is widely used for the amplification of genes through the process of POLYMERASE CHAIN REACTION. EC 2.7.7.-.

Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.

The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

Immunoglobulins produced in response to VIRAL ANTIGENS.

Antibodies produced by a single clone of cells.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. (1/17)

In the nematode Caenorhabditis elegans, there exist two micro1 medium chains of the AP-1 clathrin-associated protein complex. Mutations of unc-101, the gene that encodes one of the micro1 chains, cause pleiotropic effects (). In this report, we identified and analyzed the second mu1 chain gene, apm-1. Unlike the mammalian homologs, the two medium chains are expressed ubiquitously throughout development. RNA interference (RNAi) experiments with apm-1 showed that apm-1 and unc-101 were redundant in embryogenesis and in vulval development. Consistent with this, a hybrid protein containing APM-1, when overexpressed, rescued the phenotype of an unc-101 mutant. However, single disruptions of apm-1 or unc-101 have distinct phenotypes, indicating that the two medium chains may have distinct functions. RNAi of any one of the small or large chains of AP-1 complex (sigma1, beta1, or gamma) showed a phenotype identical to that caused by the simultaneous disruption of unc-101 and apm-1, but not that by single disruption of either gene. This suggests that the two medium chains may share large and small chains in the AP-1 complexes. Thus, apm-1 and unc-101 encode two highly related micro1 chains that share redundant and distinct functions within AP-1 clathrin-associated protein complexes of the same tissue. (+info)

Sigma 1- and mu 1-Adaptin homologues of Leishmania mexicana are required for parasite survival in the infected host. (2/17)

The sorting of membrane-bound proteins from the trans-Golgi network to lysosomal/endosomal compartments is achieved by preferential inclusion into clathrin-coated vesicles. Contained within the cytoplasmic domains of such proteins, specific sequence motifs have been identified (tyrosine-based and/or di-leucine-based) that are essential for targeting and are recognized by a family of heterotetrameric adaptor complexes, which then recruit clathrin. These cytosolic protein complexes, which have been found in a wide variety of higher eukaryotic organisms, are essential for the development of multicellular organisms. In trypanosomatids, the adaptin-mediated sorting of proteins is largely uncharacterized. In order to identify components of the adaptor-complex machinery, this study reports the cloning and characterization of sigma 1- and mu 1-adaptin gene homologues from the eukaryotic protozoan parasite, Leishmania mexicana. Generation of sigma 1- and mu 1-adaptin gene deletion mutants shows that these promastigote parasites are viable in culture, but are unable to establish infection of macrophages or mice, indicating that adaptin function is crucial for pathogenesis in these unicellular organisms. (+info)

The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. (3/17)

The adaptor protein (AP) complexes are involved in membrane transport of many proteins. There are 3 AP complexes in C. elegans unlike mammals that have four. To study the biological functions of the AP-3 complexes of C. elegans, we sought homologues of the mouse and human genes that encode subunits of the AP-3 complexes by screening C. elegans genomic and EST sequences. We identified single copies of homologues of the m3, s3, b3 and d genes. The medium chain of AP-3 is encoded by a single gene in C. elegans but two different genes in mammals. Since there are no known mutations in these genes in C. elegans, we performed RNAi to assess their functions in development. RNAi of each of the genes caused embryonic and larval lethal phenotypes. APM-3 is expressed in most cells, particularly strongly in spermatheca and vulva. We conclude that the products of the C. elegans m3, s3, b3 and d genes are essential for embryogenesis and larval development. (+info)

Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. (4/17)

In a systematic sequencing screen of the coding exons of the X chromosome in 250 families with X-linked mental retardation (XLMR), we identified two nonsense mutations and one consensus splice-site mutation in the AP1S2 gene on Xp22 in three families. Affected individuals in these families showed mild-to-profound mental retardation. Other features included hypotonia early in life and delay in walking. AP1S2 encodes an adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of coated vesicles located at the Golgi complex. The complex mediates the recruitment of clathrin to the vesicle membrane. Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations identified in the three XLMR-affected families, and such defects may plausibly cause abnormal synaptic development and function. AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles. (+info)

Mutations in the AP1S2 gene encoding the sigma 2 subunit of the adaptor protein 1 complex are associated with syndromic X-linked mental retardation with hydrocephalus and calcifications in basal ganglia. (5/17)

Fried syndrome, first described in 1972, is a rare X-linked mental retardation that has been mapped by linkage to Xp22. Clinical characteristics include mental retardation, mild facial dysmorphism, calcifications of basal ganglia and hydrocephalus. A large four-generation family in which the affected males have striking clinical features of Fried syndrome were investigated for linkage to X-chromosome markers; the results showed that the gene for this condition lies within the interval DXS7109-DXS7593 in Xp22.2. In total, 60 candidate genes located in this region, including AP1S2, which was recently shown to be involved in mental retardation, were screened for mutations. A mutation in the third intron of AP1S2 was found in all affected male subjects in this large French family. The mutation resulted in skipping of exon 3, predicting a protein with three novel amino-acids and with termination at codon 64. In addition, the first known large Scottish family affected by Fried syndrome was reinvestigated, and a new nonsense mutation, p.Gln66X, was found in exon 3. Using CT, both affected patients from the French family who were analysed had marked calcifications of the basal ganglia, as previously observed in the first Scottish family, suggesting that the presence of distinctive basal ganglia calcification is an essential parameter to recognise this syndromic disorder. It may be possible to use this feature to identify families with X-linked mental retardation that should be screened for mutations in AP1S2. (+info)

Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. (6/17)

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AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. (7/17)

AP17 and AP19 are the smallest polypeptide chain components of AP-2 and AP-1, the clathrin-associated protein complexes found in coated structures of the plasma membrane and Golgi apparatus of mammalian cells. cDNA clones representing the entire coding sequence of AP17 and AP19 were isolated from rat and mouse brain cDNA libraries, respectively. Determination of their nucleotide sequence predicts proteins of 142 and 158 amino acids with Mr 17,018 and 18,733. A sequence comparison of rat brain AP17 with mouse brain AP19 demonstrates that the small chains are highly related. A computer search for other related proteins has uncovered in yeast a previously unknown gene whose DNA sequence encodes a protein homologous to the small chain of AP complexes. The yeast sequence predicts Yap17p, a protein with 147 amino acids and a Mr of 17,373 that is slightly more related to the mammalian AP17 chain than to its AP19 counterpart. (+info)

Local clustering of transferrin receptors promotes clathrin-coated pit initiation. (8/17)

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"Entrez Gene: AP3S2 adaptor-related protein complex 3, sigma 2 subunit". CS1 maint: discouraged parameter (link) Dell'Angelica, ... AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. AP3S2 has been shown to interact with ... Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (Apr 1997). "AP-3: an adaptor-like protein complex with ... Dell'Angelica EC, Ooi CE, Bonifacino JS (1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". J. Biol. Chem. ...

https://en.wikipedia.org/wiki/AP3S2

"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...

https://en.wikipedia.org/wiki/AP1S1

"Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit". Human AP3S1 genome location and AP3S1 gene details page ... AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene. GRCh38: Ensembl release 89: ... "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". ... Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex ...

https://en.wikipedia.org/wiki/AP3S1

AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene. Adaptor protein complex 1 is found at ... "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Huo L, Teng Z, Wang H, Liu X (March 2019). "A novel ... December 2006). "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked ... The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. ...

https://en.wikipedia.org/wiki/AP1S2

AP1S2: AP-1 complex subunit sigma-2. Adaptor protein complex 1 is found on the cytoplasmic face of vesicles located at the ... "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Piccini M, Vitelli F, Bruttini M, Pober BR, Jonsson JJ ... "Mutations in the Gene Encoding the Sigma 2 Subunit of the Adaptor Protein 1 Complex, AP1S2, Cause X-Linked Mental Retardation ... This nucleolar protein is involved in the processing and modification of tRNA. GDI1: RabGDI alpha makes a complex with ...

https://en.wikipedia.org/wiki/X-linked_mental_retardation

"Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit". Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat ... AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene. One of two major clathrin-associated ... Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. ... "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1-2): ...

https://en.wikipedia.org/wiki/AP2S1

Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a ... sigma): complex 1 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 complex 2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 complex 3 AP3B1 AP3B2 ... 2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. PMC 3191125. PMID ... Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular ...

https://en.wikipedia.org/wiki/List_of_adaptins

AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ... The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and ...

https://en.wikipedia.org/wiki/Clathrin_adaptor_protein

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ...

https://en.wikipedia.org/wiki/Adaptor-related_protein_complex_2,_alpha_1

The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the ... a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with ... "Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ...

https://en.wikipedia.org/wiki/AP3M1

... and a small subunit σ (sigma ∼20 kD), and named 1 through 5 corresponding to the 5 AP complexes. Components of COPI (cop one) a ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ... but not closely related to the AP/TSET complexes. The individual proteins of the COPII complex are called SEC proteins, because ...

https://en.wikipedia.org/wiki/Vesicular_transport_adaptor_protein

AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... sigma-4 (AP4S1) AP4B1 has been shown to interact with AP4M1. AP4-complex-mediated trafficking plays a crucial role in brain ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...

https://en.wikipedia.org/wiki/AP4B1

AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. The heterotetrameric adaptor protein (AP ... "Entrez Gene: adaptor-related protein complex 4". CS1 maint: discouraged parameter (link) Abou Jamra R, Philippe O, Raas- ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ... Dell'Angelica EC, Mullins C, Bonifacino JS (1999). "AP-4, a novel protein complex related to clathrin adaptors". J. Biol. Chem ...

https://en.wikipedia.org/wiki/AP4S1

AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ... sigma-4 (AP4S1). It is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... "Entrez Gene: adaptor-related protein complex 4". Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck ...

https://en.wikipedia.org/wiki/AP4E1

The main complex of FA contains a nuclear multi-subunit complex of notably 8 FA proteins. This adds a single ubiquiting chain ... FANCE together with FANCC acts as the substrate adapter for this reaction Activated FANCD2 protein co-localizes with BRCA1 ( ... Sigma). It also then examines the use of micro satellite markers D6S422 and D6S1610, for linking. From this, a chromosomal ... This gene encodes the protein for complementation groufcrp E. A nuclear complex containing FANCE protein (as well as FANCC, ...

https://en.wikipedia.org/wiki/FANCE

... ribosomal subunits, plasmids, DNA, RNA and proteins in fixed-angle rotors. Compared to microcentrifuges or high-speed ... to characterize the assembly and disassembly mechanisms of biomolecular complexes, to determine subunit stoichiometries, to ... Swinging-bucket rotors tend to be used very widely because of the huge flexibility of sample size through the use of adaptors. ... "Centrifugation Separations". Sigma-Aldrich. Retrieved 23 November 2020. Brakke, Myron K. (April 1951). "Density Gradient ...

https://en.wikipedia.org/wiki/Centrifugation

2001). "Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of ... and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously ... 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6 ... Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene. Conventional kinesin is a tetrameric molecule ...

https://en.wikipedia.org/wiki/KLC1

... adaptor protein complex mu subunits MeSH D12.776.543.990.150.500.750 - adaptor protein complex sigma subunits MeSH D12.776. ... adaptor protein complex alpha subunits MeSH D12.776.543.990.150.500.200 - adaptor protein complex beta subunits MeSH D12.776. ... adaptor protein complex delta subunits MeSH D12.776.543.990.150.500.400 - adaptor protein complex gamma subunits MeSH D12.776. ... adaptor protein complex 4 MeSH D12.776.543.990.150.500 - adaptor protein complex subunits MeSH D12.776.543.990.150.500.100 - ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)

Sedimentation Velocity Analysis of Heterogeneous Protein-Protein Interactions: Lamm Equation Modeling and Sedimentation ... The ribosomes, membranes and Golgi complexes can be separated by another technique called density gradient centrifugation. ... The rotors may come with different adapters to hold various sizes of test tubes, bottles, or microtiter plates. ... "Sigma-Aldrich. Retrieved 10 May 2016.. *^ Article on "Centrifugation" retrieved on 15 October 2013 from http://www.lenntech.com ...

https://en.m.wikipedia.org/wiki/Centrifugation

... a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". J. Biol. Chem. 278 (36): 34641-53 ... PX-RICS was found to be a necessary component for the export of this complex to the Golgi and then onwards to the cellular ... Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector ... and weak binding to the NR2 subunits) suggests that there may be another pathway for it modifying spine structure as well. The ...

https://en.wikipedia.org/wiki/RICS_(gene)

Moreover, cingulin forms a complex with JAM-A, a tight junction membrane protein. Most of cingulin protein interactions are ... Aijaz S, D'Atri F, Citi S, Balda MS, Matter K (May 2005). "Binding of GEF-H1 to the tight junction-associated adaptor cingulin ... Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector ... each subunit containing a N-terminal globular "head" domain, a long α-helical coiled-coil "rod" domain and a small globular C- ...

https://en.wikipedia.org/wiki/Cingulin

The adaptor molecules were eventually shown to be tRNAs and the catalytic "ribonucleic-protein complexes" became known as ... Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 ... ribonucleic-protein complexes that catalyse the assembly of amino acids into proteins according to the messenger RNA ... Sigma Xi. Hidden categories: *Pages using ISBN magic links. *Use British English from August 2012 ...

https://en.wikipedia.org/wiki/Francis_Crick?oldid=752748384

Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many ... G-protein coupled receptor signaling pathway. • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway. • G- ... clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2 unable to mobilize ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...

https://en.wikipedia.org/wiki/GPR44

Signal transducing adaptor protein. *Scaffold protein. Transcription factors. *General. *Transcription preinitiation complex ... They have a heteromeric structure in that each subunit consists of the extracellular ligand-binding domain and a transmembrane ... and can be a protein or peptide (short protein), or another small molecule such as a neurotransmitter, hormone, pharmaceutical ... In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.[1] When ...

https://en.wikipedia.org/wiki/Receptor_

AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...

https://en.wikipedia.org/wiki/Beta2-adaptin_C-terminal_domain

Compare adaptor related protein complex 2 subunit sigma 1 ELISA Kits from leading suppliers on Biocompare. View specifications ... adaptor related protein complex 2 subunit sigma 1 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well- ... Your search returned 34 adaptor related protein complex 2 subunit sigma 1 ELISA ELISA Kit across 3 suppliers. ... Watch Webinar: How To Get Speed and Depth in your Host Cell Protein (HCP) Analysis ...

https://www.biocompare.com/pfu/110627/soids/2-2268932/ELISA_Kit/ELISA_adaptor_related_protein_complex_2_sigma_1_subunit

... adaptor related protein complex 4 sigma 1 subunit), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... AP4S1 (adaptor related protein complex 4 sigma 1 subunit). Identity. Alias_names. adaptor-related protein complex 4, sigma 1 ... transporter activity clathrin-coated pit protein transporter activity protein transport endosome lumen trans-Golgi network ... transporter activity clathrin-coated pit protein transporter activity protein transport endosome lumen trans-Golgi network ...

http://atlasgeneticsoncology.org/Genes/GC_AP4S1.html

... sigma 2 Subunit (AP1S2) Protein (His tag). Spezies: Maus. Quelle: Escherichia coli (E. coli). Jetzt Produkt ABIN3129522 ... Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) Hintergrund. Subunit of clathrin-associated adaptor protein complex ... Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) (AA 1-160) protein (His tag) Protein AP1S2 Spezies: Maus Quelle: ... Adaptor-Related Protein Complex 1, sigma 2 Subunit (AP1S2) (AA 1-157) protein (His tag) Protein ...

https://www.antikoerper-online.de/protein/3129522/Adaptor-Related+Protein+Complex+1,+sigma+2+Subunit+AP1S2+AA+1-160+protein+His+tag/

adaptor-related protein complex 2, sigma 1 subunit. Gene nomenclature, locus information, and GO, OMIM, and PMID associations ... OMIM: HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE III; HHC3, ADAPTOR-RELATED PROTEIN COMPLEX 2, SIGMA-1 SUBUNIT; AP2S1*Gene ...

https://www.komp.org/geneinfo.php?geneid=23444

... "adaptor-related protein complex 1, sigma 2 subunit")*CCDS: 30514, 30514.1, 72465, 72466*OMIM: ADAPTOR-RELATED PROTEIN COMPLEX 1 ... adaptor-related protein complex 1, sigma 2 subunit. Synonyms: 1500012A13Rik, EST1. Gene nomenclature, locus information, and GO ... SIGMA-2 SUBUNIT; AP1S2, MENTAL RETARDATION, X-LINKED 59; MRX59*Gene Ontology: Ap1s2 *Mouse Phenome DB: Ap1s2 *UCSC: Chr.X: ...

https://www.komp.org/geneinfo.php?geneid=23436

Creative Biomart offer ap3s2 proteins for life sciences research. All the products are rigorously tested to meet the most ... AP3S2;adaptor-related protein complex 3, sigma 2 subunit;AP-3 complex subunit sigma-2;sigma3b;sigma-3B-adaptin;sigma-adaptin 3b ... adaptor complex sigma3B;AP-3 complex subunit sigma-3B;clathrin-associated/assembly/adaptor protein, small 4, 22-kD;AP3S3; ... Protein Function. AP3S2 has several biochemical functions, for example, protein transporter activity. Some of the functions are ...

https://www.creativebiomart.net/symbolsearch_AP3S2.htm

What is Adapter-related protein complex 1 sigma-1A subunit? Meaning of Adapter-related protein complex 1 sigma-1A subunit ... What does Adapter-related protein complex 1 sigma-1A subunit mean? ... Adapter-related protein complex 1 sigma-1A subunit explanation free. ... Looking for online definition of Adapter-related protein complex 1 sigma-1A subunit in the Medical Dictionary? ...

https://medical-dictionary.thefreedictionary.com/Adapter-related+protein+complex+1+sigma-1A+subunit

Protein Coding), Adaptor Related Protein Complex 1 Subunit Sigma 3, including: function, proteins, disorders, pathways, ... sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved ... sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved ... AP1S3 (Adaptor Related Protein Complex 1 Subunit Sigma 3) is a Protein Coding gene. Diseases associated with AP1S3 include ...

https://www.genecards.org/cgi-bin/carddisp.pl?gene=AP1S3&keywords=GH02J223796&prefilter=genomic_location

adaptor related protein complex 4 subunit sigma 1. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ... The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin- ... This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the ...

https://ghr.nlm.nih.gov/gene/AP4S1

AP1S2 encodes an adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of coated ... Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations ... AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles. ... The complex mediates the recruitment of clathrin to the vesicle membrane. ...

https://www.tropicalmedicine.ox.ac.uk/publications/998620

AP-1 complex subunit sigma-3 , adapter-related protein complex 1 sigma-1C subunit , adaptor protein complex AP-1 sigma-1C ... anti-Adaptor-Related Protein Complex 3, sigma 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 3, sigma 2 Subunit ... anti-Adaptor-Related Protein Complex 1, sigma 2 Subunit Antikörper * anti-Adaptor-Related Protein Complex 1, mu 2 Subunit ... anti-Adaptor-Related Protein Complex 2, mu 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 2, sigma 1 Subunit ...

http://www.antikoerper-online.de/abstract/AdaptorRelated+Protein+Complex+1%2C+sigma+3+Subunit+

The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the ... Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi ... Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi ... help/subunit_structure target=_top>More...,/a>,/p>Subunit structurei. Adaptor protein complex 1 (AP-1) is a heterotetramer ...

https://www.uniprot.org/uniprot/P61967

AP-3 complex sigma-3A subunit; AP-3 complex subunit sigma-1; AP-3 complex subunit sigma-3A; adapter-related protein complex 3 ... sigma-1 subunit; clathrin-associated/assembly/adapter protein, small 3; clathrin-associated/assembly/adaptor protein, small 3 ( ... AP3S1 belongs to the adaptor complexes 3 (AP3) small subunit family which is not clathrin-associated. The complex is associated ...

https://www.fishersci.com/shop/products/anti-ap3s1-polyclonal-pa5-21161/PIPA521161

adaptor-related protein complex 1, sigma 2 subunit [Source:HGNC Symbol;Acc:560]. Mouse Orthologue:. Ap1s2. Mouse Description:. ... adaptor-related protein complex 1, sigma 2 subunit Gene [Source:MGI Symbol;Acc:MGI:1889383]. ...

https://www.sanger.ac.uk/sanger/Zebrafish_Zmpgene/ENSDARG00000088555

"Entrez Gene: AP3S2 adaptor-related protein complex 3, sigma 2 subunit". CS1 maint: discouraged parameter (link) DellAngelica, ... AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. AP3S2 has been shown to interact with ... DellAngelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (Apr 1997). "AP-3: an adaptor-like protein complex with ... DellAngelica EC, Ooi CE, Bonifacino JS (1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". J. Biol. Chem. ...

https://en.wikipedia.org/wiki/AP3S2

https://en.wikipedia.org/wiki/AP1S1

adaptor-related protein complex 3, sigma 1 subunit. Protein Similarities Based on Shared Motif Content. ... CC] AP-3 adaptor complex *[CC] AP-type membrane coat adaptor complex *[CC] Golgi apparatus *[CC] cytoplasmic vesicle membrane * ... BP] intracellular protein transport *[BP] vesicle-mediated transport *[ ... AP3S1, adaptor-related protein complex 3, sigma 1 subunit. Sequence ID:. NM_001002924. NM_001284. ...

https://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=740519&LLNO=1176

adaptor related protein complex 3 subunit sigma 1. Gene Type： protein-coding Organism： Homo sapiens Chromosome： 5 NCBI GeneID： ...

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201608012670059089

Adaptor-related protein complex 2, sigma 1 subunit. NM_004069. NM_021575. Gene Info. ... PML-RARA regulated adaptor molecule 1. NM_032152. Gene Info. PRKAA1. Protein kinase, AMP-activated, alpha 1 catalytic subunit. ... Low density lipoprotein receptor adaptor protein 1. NM_015627. Gene Info. LGI3. Leucine-rich repeat LGI family, member 3. NM_ ... Mindbomb E3 ubiquitin protein ligase 1. NM_020774. Gene Info. MIB1. Mindbomb E3 ubiquitin protein ligase 1. BX648566. Gene Info ...

https://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0060627

Description adaptor-related protein complex 3, sigma 2 subunit Also known as AP3S3, sigma3b ...

https://www.addgene.org/browse/gene/10239/

adaptor related protein complex 1 sigma 1 subunit. The protein encoded by this gene is part of the clathrin coat assembly ... adaptor related protein complex 1 sigma 1 subunit. AP19;CLAPS1;EKV3;MEDNIK;SIGMA1A. NM_001283.3. rs13225397. ... adaptor related protein complex 1 sigma 1 subunit. AP19;CLAPS1;EKV3;MEDNIK;SIGMA1A. NM_001283.3. rs2239537. ... adaptor related protein complex 1 sigma 1 subunit. AP19;CLAPS1;EKV3;MEDNIK;SIGMA1A. NM_001283.3. rs61414985. ...

https://www.thermofisher.com/order/genome-database/browse/genotyping/keyword/AP1S1

Adaptor-related protein complex 1, sigma 3 subunit Aliases:. Not Available. RefSeq:. Not Available. ...

http://www.bio-rad.com/en-us/prime-pcr-assays/assay/qrnocip0040361-primepcr-probe-assay-ap1s3-rat

Adaptor-related protein complex 3, sigma 2 subunit Aliases:. Not Available. RefSeq:. NM_001159342. ...

http://www.bio-rad.com/en-us/prime-pcr-assays/assay/qggaced0029976-primepcr-sybr-green-assay-ap3s2-chicken

adaptor related protein complex 3 sigma 1 subunit. protein-coding. APOBEC3A. apolipoprotein B mRNA editing enzyme catalytic ... adaptor related protein complex 3 beta 1 subunit. protein-coding. APBA2. amyloid beta precursor protein binding family A member ... adaptor related protein complex 4 epsilon 1 subunit. protein-coding. ACP7. acid phosphatase 7, tartrate resistant (putative). ... anaphase promoting complex subunit 4. protein-coding. AIFM2. apoptosis inducing factor, mitochondria associated 2. protein- ...

https://www.genscript.com/gene/9606/homo-sapiens?search=a&page=6

C15orf38-AP3S2 readthrough;adaptor related protein complex 3 sigma 2 subunit. AP3S3;sigma3b. NM_001199058.1;NM_005829.4. rs7111 ... C15orf38-AP3S2 readthrough;adaptor related protein complex 3 sigma 2 subunit. AP3S3;sigma3b. NM_001199058.1;NM_005829.4. ... C15orf38-AP3S2 readthrough;adaptor related protein complex 3 sigma 2 subunit. AP3S3;sigma3b. NM_001199058.1;NM_005829.4. ... C15orf38-AP3S2 readthrough;adaptor related protein complex 3 sigma 2 subunit. AP3S3;sigma3b. NM_001199058.1;NM_005829.4. ...

https://www.thermofisher.com/order/genome-database/browse/genotyping/keyword/AP3S2

... a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with ... AP-3 complex subunit mu-1. Names. AP-3 adapter complex mu3A subunit. adapter-related protein complex 3 mu-1 subunit. adaptor ... AP3M1 adaptor related protein complex 3 subunit mu 1 [Homo sapiens] AP3M1 adaptor related protein complex 3 subunit mu 1 [Homo ... The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the ...

https://www.ncbi.nlm.nih.gov/gene/26985

Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma ... clathrin Associated Protein complex Small subunit 1 Comparative Info. Sequence Details Sequence The S. cerevisiae Reference ... Complex Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from ... protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, ...

https://www.yeastgenome.org/locus/S000003561

... adaptor related protein complex 3 sigma 1 subunit) for WB. Anti-AP3S1 pAb (GTX45817) is tested in Human samples. 100% Ab- ... adaptor related protein complex 3 sigma 1 subunit. Synonyms. SIGMA3A Antibody , AP3S1 Antibody , CLAPS3 Antibody. ... Primary Antibodies Secondary Antibodies Proteins & Peptides Lysates & Slides Serum & Reagents Research Kits Isotype Controls ...

http://www.genetex.com/AP3S1-antibody-N-term-GTX45817.html

Adaptor Related Protein Complex 1 Subunit Sigma 2. Protein Coding. 18.26. GeneCards inferred via :. Publications (show sections ... Adaptor Related Protein Complex 1 Subunit Sigma 2). Affiliated tissues include brain. ...

https://www.malacards.org/card/dandy_walker_malformation_with_intellectual_disability_basal_ganglia_disease_and_seizures

... sigma 1 subunit) for ELISA, ICC/IF, IHC-P, WB. Anti-AP3S1 pAb (GTX31839) is tested in Human, Mouse samples. 100% Ab-Assurance. ... adaptor-related protein complex 3, sigma 1 subunit. Synonyms. adaptor-related protein complex 3, sigma 1 subunit Antibody , ... Primary Antibodies Secondary Antibodies Proteins & Peptides Lysates & Slides Serum & Reagents Research Kits Isotype Controls ... AP3S1 antibody is predicted to not cross-react with other AP3 protein family members. ...

http://www.genetex.com/AP3S1-antibody-GTX31839.html

AP1S2 encodes an adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of coated vesicles located at the Golgi complex. (ox.ac.uk)
This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. (wikipedia.org)
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. (genecards.org)
The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). (genecards.org)
AP-3 complex is composed of two large adaptins (AP3D1 and AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). (ptglab.com)
Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1 ), a medium adaptin (mu-type subunit AP1M1 or AP1M2 ) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3 ). (rcsb.org)
Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2 ), a medium adaptin (mu-type subunit AP3M1 or AP3M2 ) and a small adaptin (sigma-type subunit APS1 or AP3S2 ) (By similarity). (rcsb.org)
Beta adaptin is a subunit of the plasma membrane CC adaptor (By similarity). (univ-lyon1.fr)
SUBUNIT: Adaptor protein complex 2 (AP-2) is a heterotetramer CC composed of two large adaptins (alpha-type subunit apl3 and beta- CC type subunit apl1), a medium chain (mu-type subunit apm4) and a CC small adaptin (sigma-type subunit aps2). (univ-lyon1.fr)
Adaptin subunits recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal appendage domains. (embl.de)
By contrast, GGAs are monomers composed of four domains, which have functions similar to AP subunits: an N-terminal VHS (Vps27p/Hrs/Stam) domain, a GAT (GGA and Tom1) domain, a hinge region, and a C-terminal GAE (gamma-adaptin ear) domain. (embl.de)
Also known as AP-2 complex subunit alpha (Alpha-adaptin). (mybiosource.com)
Also known as AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit). (mybiosource.com)
Also known as AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit). (mybiosource.com)
Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). (icr.ac.uk)

PREDICTED- similar to Ap1s1 protein [Hydra magnipapillata]. (string-db.org)

p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)

For the human and simian immunodeficiency viruses (HIV and SIV), sorting of the viral envelope proteins (Env) to assembly sites is directed by trafficking signals located in the cytoplasmic domain of the transmembrane protein gp41 (TM). (genes2cognition.org)
As examined by electron microscopy, HCV proteins induced formation of large electron-dense cytoplasmic structures derived from the ER and containing HCV proteins. (biomedcentral.com)
Clathrin-associated CC protein complexes are believed to interact with the cytoplasmic CC tails of membrane proteins, leading to their selection and CC concentration. (univ-lyon1.fr)
They bind to sorting signals in the cytoplasmic tails of cargo proteins, recruit clathrin and other accessory proteins, and then concentrate the cargo proteins into vesicular carriers, which transport from the donor membrane to the target organelle membrane ( Figure 1 ). (bioscirep.org)
Among the earliest detectable effects in engaged T cells are the phosphorylation of multiple cellular substrates on tyrosine residues, including the cytoplasmic tails of the TCR subunits ( 3 , 4 , 5 ). (jimmunol.org)

A gene on chromosome 7q22.1 that encodes a subunit of the trans-Golgi network clathrin-associated protein complex AP-1, which is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. (thefreedictionary.com)
The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. (genecards.org)
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. (genecards.org)
AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (nih.gov)
The complex is associated with the Golgi region as well as more peripheral structures. (fishersci.com)
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. (nih.gov)
AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. (nih.gov)
AP3 plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes, as well as in biogenesis of melanosomes, platelet dense granules and lysosomes. (thefreedictionary.com)
AP3S2 is a subunit of the AP-3 complex which is associated with the Golgi region as well as more peripheral structures. (ptglab.com)
In the course of HCV protein production, there is disruption of the Golgi apparatus, loss of spatial organization of the ER, appearance of some "virus-like" structures and swelling of mitochondria. (biomedcentral.com)
Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (embl.de)
Acts as a clathrin adapter required for post-Golgi trafficking. (string-db.org)
X‐chromosome‐encoded σ1B is one out of three isogenes (termed A-C) for the tiny σ subunit of AP‐1 (comprising γ1, β1, μ1 and σ1 adaptins) localized to the trans‐Golgi network (TGN) and endosomes. (embopress.org)
We are calling this complex AP-3, a name that has also been used for the neuronalspecific phosphoprotein AP180, but we feel that it is amore appropriate designation for an adaptor-related heterotetramer.Immunofluorescence using anti-delta antibodies reveals that the AP-3 complex isassociated with the Golgi region of the cell as well as with more peripheralstructures. (embl.de)
Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (uniprot.org)
The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (uniprot.org)
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (uniprot.org)

AMP-activated protein kinase (AMPK) is expressed ubiquitously and is activated by increases in AMP and/or ADP relative to ATP, thus acting as a sensor of cellular energy status [ 1 - 3 ]. (portlandpress.com)
AMPK complexes are activated by upstream kinases that phosphorylate a conserved threonine residue (Thr 172 in rat α2 [ 9 ]) within the activation loop of the α subunit kinase domain. (portlandpress.com)
Four of the verified genes (solute carrier family 9 isoform 3 regulator 1 (Slc9a3r1), sorbitol dehydrogenase 1, a kinase anchor protein, and glutathione S-transferase alpha 4) were induced. (springer.com)
In this model, we observed that HCV proteins control cellular translation through eIF-2α-S51 phosphorylation, with involvement of the double-stranded RNA-dependent protein kinase PKR. (biomedcentral.com)
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that plays an important role in extracellular calcium homeostasis by stimulating intracellular calcium signaling and mitogen-activated protein kinase (MAPK) pathways. (sciencemag.org)
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through G q/11 and G i/o to stimulate cytosolic calcium (Ca 2+ i ) and mitogen-activated protein kinase (MAPK) signaling to control extracellular calcium homeostasis. (sciencemag.org)
The Chk1 protein kinase preserves genome integrity in normal proliferating cells and in cells experiencing replicative and genotoxic stress. (aacrjournals.org)
Chk1 is a serine/threonine protein kinase that functions to maintain genome integrity in normal cycling cells and in cells exposed to replicative and genotoxic stress ( 1 , 2 ). (aacrjournals.org)
Drugs that block Chk1 kinase activity or enhance its proteolysis by interfering with binding to heat shock protein 90 (HSP90) are currently being tested as anticancer agents ( 14 - 17 ). (aacrjournals.org)
The Zap70 protein tyrosine kinase controls TCR-linked signal transduction pathways and is critical for T cell development and responsiveness. (jimmunol.org)
We have shown previously that the CT10 regulator of kinase II (CrkII) adapter protein interacts with tyrosine-phosphorylated Zap70 in TCR-engaged T cells, and now extend these studies to show that Tyr 315 in the Zap70 interdomain B region is the site of interaction with CrkII. (jimmunol.org)
Phosphorylation of Tyr 315 and Zap70 association with CrkII were both dependent upon the Lck protein tyrosine kinase. (jimmunol.org)
AKT/PKB is a serine/threonine protein kinase that plays an important role in cell survival, protein synthesis, and controlled inflammation in response to TLRs. (jimmunol.org)

This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. (genecards.org)
Downregulation of genes encoding for subunits of adaptor complex-3 in cervical carcinomas. (nih.gov)
in humans, all three subunits are encoded by multiple genes, i.e. (portlandpress.com)
Two genes (proteasome subunit, beta type 10 and adaptor-related protein complex AP-4 sigma 1) were suppressed. (springer.com)
We also identified eight growth factors and growth factor receptor genes that are significantly altered by each of the HDIs, including Frizzled related proteins 1 and 4, which modulate the Wnt signaling pathway. (springer.com)
All genes encoding for the proteins part of this complex have been associated with genetic forms of HSP (e.g. (biomedcentral.com)
In fact, genes only comprise 2% of human genome or encoded proteins and the remaining noncoding portions of the genome transcription products are noncoding RNAs which differ in biogenesis and function. (asmepress.com)
Identification of additional genes under the control of the transcription factor sigma F of Bacillus subtilis. (antibody-antibodies.com)
Mutations of the CASR , the G protein alpha 11 ( GNA11 ) and the adaptor-related protein complex 2 sigma 1 subunit ( AP2S1 ) genes can shift the set point for calcium sensing causing hyper- or hypo-calcemic disorders. (bioscientifica.com)
Recovery of cellular respiration, mitochondrial biogenesis, and function requires coordinated expression of transcription factors encoded by nuclear and mitochondrial genes, including mitochondrial transcription factor A (T-fam) and cytochrome c oxidase (COX, complex IV). (jimmunol.org)
De novo variants in genes mainly encoding ion channel and synaptic proteins have been found to account for over 15% of patients with IS or LGS. (uni.lu)

AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). (nih.gov)
A gene on chromosome 5q14.1 that encodes a subunit of the heterotetrameric AP3 complex, a protein complex composed of two large subunits (delta and beta), a medium subunit (mu), and a small subunit (sigma). (thefreedictionary.com)
All AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). (embl.de)

As an original manufacturer for its entire catalog of antibodies and proteins, we are here to support you. (ptglab.com)
Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
171 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) Antibodies from 23 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
Antibodies raisedagainst recombinant delta and sigma3 show that they are the other two subunits ofthe adaptor-like complex. (embl.de)

The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. (mybiosource.com)
Note=Binds 0.5 mol of zinc/mol protein, probably 1 zinc per dimer. (antibody-antibodies.com)
Under periods of replicative stress, the ATRIP/ATR module binds to single-stranded DNA and, together with Rad17 and the 9-1-1 complex, activates Chk1 in a Claspin-dependent manner ( 18 - 22 ). (aacrjournals.org)

Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. (nih.gov)
In the locked state, the cargo-binding sites of AP-1 are hindered by two large subunits (γ and β1). (bioscirep.org)

FUNCTION: Adaptins are components of the adaptor complexes which CC link clathrin to receptors in coated vesicles. (univ-lyon1.fr)
This entry represents the small sigma and mu subunits of various adaptins from different AP clathrin adaptor complexes (including AP1, AP2, AP3 and AP4), and the zeta and delta subunits of various coatomer (COP) adaptors. (embl.de)

AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. (genecards.org)
AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. (genecards.org)
A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein. (genes2cognition.org)
A membrane proximal conserved GYxxØ motif mediates endocytosis through interaction with the clathrin adaptor AP-2. (genes2cognition.org)
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. (string-db.org)
SVs display a specific protein and lipid composition that enables them to store and release the neurotransmitter, to be targeted to or cluster near release sites, and to undergo multiple rounds of exo‐endocytosis. (embopress.org)

The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. (mybiosource.com)
This region contains the gene GNA11 that codes for the alpha subunit of G 11 . (asbmr.org)
Following on this clue, plus the known association of the alpha subunit of G 11 with calcium receptor signaling and the finding that mice with parathyroid-specific deletion of both G q and G 11 develop hypercalcemia and hyperparathyroidism, Nesbit et al (3) investigated the role that mutations in G 11 had in the development of Type 2 FHH. (asbmr.org)

The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. (nih.gov)
AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles. (ox.ac.uk)
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. (wikipedia.org)
The assembly of AP-3 adaptor complex-containing clathrin-coated vesicles on synthetic liposomes. (nih.gov)
Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. (genecards.org)
In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. (rcsb.org)
This traffic is bidirectional, to ensure that proteins required to form vesicles are recycled. (embl.de)
Clathrin coats contain both clathrin and adaptor complexes that link clathrin to receptors in coated vesicles. (embl.de)
In the endocytic and secretory pathways, cargo proteins destined for transport to distinct locations are collectively assembled into vesicles and delivered to their target sites by vesicular trafficking. (bioscirep.org)
We have recently shown that two proteins related to two of the adaptor subunitsof clathrincoated vesicles, p47 (mu3) and beta-NAP (beta3B), are part of anadaptor-like complex not associated with clathrin (Simpson, F., N.A. Bright, M.A.West, L.S. Newman, R.B. Darnell, and M.S. Robinson, 1996. (embl.de)

These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. (nih.gov)
Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. (ptglab.com)

CLA20 is a reported synonym of the human protein 'adaptor related protein complex 4 subunit sigma 1', encoded by the gene AP4S1. (biocompare.com)

The AP (adaptor protein) complexes are heterotetrameric protein complexes that mediate intracellular membrane trafficking along endocytic and secretory transport pathways. (bioscirep.org)
These five AP complexes localize to different intracellular compartments and mediate membrane trafficking in distinct pathways. (bioscirep.org)
They recognize and concentrate cargo proteins into vesicular carriers that mediate transport from a donor membrane to a target organellar membrane. (bioscirep.org)
Also important in this regulatory system is the G q /G 11 family of trimeric G proteins, which mediate the regulation of PLC--‐β by the CSR (1, 2) . (asbmr.org)
Whereas the TCR subunits are devoid of enzymatic activity, several nonreceptor protein tyrosine kinases (PTKs), 3 which are constitutively associated with, or recruited to the activated TCR, mediate the phosphorylation of the receptor subunits, as well as other substrates at the immunological synapse. (jimmunol.org)

There are 1193 AP3B1_C domains in 1191 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing AP3B1_C domain. (embl.de)
The complete taxonomic breakdown of all proteins with AP3B1_C domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing AP3B1_C domain in the selected taxonomic class. (embl.de)

Mouse Ap1s2 Protein (raised in E. Coli) purified by multi-step, protein-specific process to ensure crystallization grade. (antikoerper-online.de)
Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. (ox.ac.uk)
Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations identified in the three XLMR-affected families, and such defects may plausibly cause abnormal synaptic development and function. (ox.ac.uk)
An important gene associated with Dandy-Walker Malformation with Intellectual Disability, Basal Ganglia Disease and Seizures is AP1S2 (Adaptor Related Protein Complex 1 Subunit Sigma 2). (malacards.org)
2007). Mutations in the AP1S2 gene encoding the sigma 2 subunit of the adaptor protein 1 complex are associated with syndromic X-linked mental retardation with hydrocephalus and calcifications in basal ganglia. . (cnrs.fr)

They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). (nih.gov)
The CaSR couples to multiple G proteins, in a tissue-specific manner, activating several signalling pathways and thus regulating diverse intracellular events. (bvsalud.org)

We addressed whether complexes containing different γ isoforms display different responses to adenine nucleotides by generating cells stably expressing FLAG-tagged versions of the γ1, γ2 or γ3 isoform. (portlandpress.com)
Thus, AMPK complexes containing different γ subunit isoforms respond differently to changes in AMP, ADP or ATP. (portlandpress.com)
Combinatorial assembly of different subunit isoforms gives rise to diverse AP heterotetramers, which may display tissue-specific expression and function [ 1 ]. (bioscirep.org)
2 isoforms of the human protein are produced by alternative splicing. (mybiosource.com)

In this study, we show that the AP-2 endocytic adaptor complex is required for the internalization of the major cell wall biosynthesis enzyme Chs3. (asm.org)
The study also highlights key distinctions between endocytic requirements of growth at yeast buds compared to that at hyphal tips and different requirements of AP-2 in maintaining the polarity of mannosylated proteins and ergosterol at hyphal tips. (asm.org)
Together, our findings highlight the importance of correct cell wall deposition in cell shape maintenance and polarized growth and the key regulatory role of endocytic recycling via the AP-2 complex. (asm.org)

In addition, they phosphorylate scaffold proteins that have no enzymatic activity, such as linker for activation of T cells, SH2 domain-containing leukocyte protein of 76 kDa, and Cbl, which function as docking sites for Src homology 2 (SH2)/SH3-containing effector molecules ( 10 ). (jimmunol.org)

Despite this, all three complexes were activated, due to increased Thr 172 phosphorylation, when cells were incubated with mitochondrial inhibitors that increase cellular AMP. (portlandpress.com)
However, effects of AMP or ADP on activation and phosphorylation of the γ2 and γ3 complexes were small or insignificant. (portlandpress.com)
The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. (uniprot.org)
In addition to regulating DNA replication and mitotic entry, Chk1 has also been shown to stabilize stalled replication forks when DNA replication is impeded, to regulate transcription through phosphorylation of histone H3, and to regulate DNA repair by phosphorylating the Fanconi anemia protein FANCE ( 8 , 10 - 12 ). (aacrjournals.org)
We show that LPS challenge led to increased expression of T-fam and COX subunits I and IV in a time-dependent manner through early phosphorylation of the PI3K/AKT pathway. (jimmunol.org)
Three major clusters of interacting proteins emerged: (a) signaling, (b) DNA repair, and (c) oxidative phosphorylation. (biomedcentral.com)
Key to its regulation is the phosphorylation of the retinoblastoma protein (pRb or RB1) by active cyclin D-CDK4/6 and cyclin E-CDK2 complexes in early and late G1, respectively, an event that results in the release of E2F transcription factors that signal the cell to continue into the S-phase, replicate and proliferate. (biomedcentral.com)
Insulin activates a tyrosine phosphorylation cascade that branches to create a complex network affecting multiple biological processes. (pnas.org)
Reversible phosphorylation is a major regulatory mechanism controlling the activity of proteins. (pnas.org)
Insulin or IGF-1 binding initiates a complex cascade of events, starting with phosphorylation of specific tyrosine residues on the insulin and the IGF-1 receptors ( 2 ). (pnas.org)
Labeling three cell states by SILAC allows measuring a time course of activation of tyrosine phosphorylation by quantifying the relative protein amounts after anti-phosphotyrosine immunoprecipitation. (pnas.org)

False positives and redundant hits were filtered out using empirical criteria and a calculated interaction confidence score, producing a data set of 6463 interactions between 2235 distinct proteins. (genes2cognition.org)
Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2. (genes2cognition.org)
We demonstrate that this interaction is mediated by the AP-2 mu subunit (Apm4) YXXΦ binding domain. (asm.org)
Hinge and ear domains are important to the interaction with coat proteins and regulatory/accessory proteins. (bioscirep.org)
When both Gin and sigma-G are expressed in E.coli Gin inhibits sigma-G, strongly suggesting Gin inhibits by direct physical interaction ( PubMed:19497328 ). (antibody-antibodies.com)
Biological characterization of the data, selection of cancer markers, and identification of protein interaction networks was accomplished with a combination of bioinformatics tools provided by GoMiner, DAVID and STRING. (biomedcentral.com)

Mutational analysis of the adaptor protein 2 sigma subunit (AP2S1) gene: search for autosomal dominant hypocalcemia type 3 (ADH3). (ox.ac.uk)
Loss-of-function mutations of adaptor protein-2 sigma subunit (AP2σ 2), encoded by AP2S1, cause FHH3, and we therefore sought for gain-of-function AP2S1 mutations that may cause an additional form of ADH, which we designated ADH3. (ox.ac.uk)

Adaptor protein complexes AP-1 and AP-3 are required by the HHV-7 Immunoevasin U21 for rerouting of class I MHC molecules to the lysosomal compartment. (nih.gov)
Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. (nih.gov)

Also, other proteins which involved in the same pathway with AP3S2 were listed below. (creativebiomart.net)
AP3S2 has several biochemical functions, for example, protein transporter activity. (creativebiomart.net)
Some of the functions are cooperated with other proteins, some of the functions could acted by AP3S2 itself. (creativebiomart.net)
We selected most functions AP3S2 had, and list some proteins which have the same functions with AP3S2. (creativebiomart.net)
AP3S2 has direct interactions with proteins and molecules. (creativebiomart.net)
We selected proteins and molecules interacted with AP3S2 here. (creativebiomart.net)
AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. (wikipedia.org)
AP3S2 is a 22-kDa protein that belongs to the adaptor complexes small subunit family. (ptglab.com)

This gene encodes a member of the adaptor complexes small subunit protein family. (nih.gov)
This gene encodes the small chain of this complex. (abnova.com)
The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. (nih.gov)
From NCBI Gene: This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. (nih.gov)
From NCBI Gene: This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. (nih.gov)
From NCBI Gene: This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. (nih.gov)
From NCBI Gene: This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. (nih.gov)
This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. (antibodies-online.com)
This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. (antibodies-online.com)

The complex mediates the recruitment of clathrin to the vesicle membrane. (ox.ac.uk)
The AP4M1 belongs to a complex that mediates vesicle trafficking of glutamate receptors, being likely involved in brain development and neurotransmission. (biomedcentral.com)

AP3S1 belongs to the adaptor complexes 3 (AP3) small subunit family which is not clathrin-associated. (fishersci.com)
This complex is composed of two large chains, a medium chain, and a small chain. (abnova.com)
It is listed to be a member of the Adaptor complexes small subunit family. (biocompare.com)
PREDICTED- similar to clathrin-associated adaptor complex AP-1 small chain sigma1, partial [Hydra magnipapillata]. (string-db.org)

Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). (genecards.org)
In addition, via our preliminary analysis, we report many novel protein interactions and pathway associations. (genes2cognition.org)
The highly-conserved Notch signaling pathway is unique, as both the Notch receptor and most of its respective ligands (canonically the DSL or Delta/Serrate/lag-2 family members) are transmembrane proteins attached to the cell surface. (antibodies-online.com)
Proteins required for nutrient uptake or cell wall biosynthesis in the new environment are incorporated into the plasma membrane via the secretory pathway. (asm.org)
The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules (PMID:10024875). (embl.de)
This study shows that Chk1 abundance is regulated by the Cul4A/DDB1 ubiquitin ligase during an unperturbed cell division cycle, in response to replicative stress and on heat shock protein 90 inhibition, and that deregulation of the Chk1/Cul4A/DDB1 pathway perturbs the ionizing radiation-induced G 2 checkpoint. (aacrjournals.org)
We identify different protein "effector" classes that influence distinct branches of the insulin signaling pathway. (pnas.org)

CONTEXT: Autosomal dominant hypocalcemia (ADH) types 1 and 2 are due to calcium-sensing receptor (CASR) and G-protein subunit-α11 (GNA11) gain-of-function mutations, respectively, whereas CASR and GNA11 loss-of-function mutations result in familial hypocalciuric hypercalcemia (FHH) types 1 and 2, respectively. (ox.ac.uk)
The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, Î³-glutamyl peptides, polyamines, polycationic peptides, and protons. (bvsalud.org)
SIGNIFICANCE STATEMENT: The calcium-sensing receptor (CaSR) is a complex G protein-coupled receptor that possesses multiple orthosteric and allosteric binding sites, is subject to biased signaling via several different G proteins, and has numerous (patho)physiological roles. (bvsalud.org)
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that plays a key role in calcium homeostasis, by sensing free calcium levels in blood and regulating parathyroid hormone secretion in response. (bvsalud.org)
This unit outlines a live-cell imaging approach developed for visualization of intracellular calcium flux in human parathyroid tumors following stimulation of the calcium-sensing receptor (CASR), a class C G protein-coupled receptor (GPCR). (readbyqxmd.com)

As determined by confocal microscopy, HCV proteins expressed from VT7-HCV7.9 localize largely in a globular-like distribution pattern in the cytoplasm, with some proteins co-localizing with the endoplasmic reticulum (ER) and mitochondria. (biomedcentral.com)

the AP complexes recruit clathrin to membranes and recognise sorting signals within the cytosolic tails of transmembrane cargo molecules. (thefreedictionary.com)
These include the Src family members, Lck and Fyn, which constitutively associate with the TCR/CD3 and the CD4/CD8 coreceptors, respectively, and Zap70, a cytosolic PTK that is recruited to the activated TCR and interacts with its tyrosine-phosphorylated receptor subunits ( 6 , 7 ). (jimmunol.org)
heat shock protein 90kDa alpha (cytosolic. (broadinstitute.org)

protein phosphatase 2, regulatory subunit. (broadinstitute.org)

Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. (nih.gov)
Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. (genecards.org)

Assembly Protein Complex 3 Human Recombinant produced in E.Coli is a non-glycosylated, polypeptide chain containing amino acids (1-193) and having a total molecular mass of 22.2 kDa. (avivasysbio.com)
The transient assembly of functional molecular complexes in activated T cells enables the recruitment of enzymes and other effector molecules to specific compartments at the immunological synapse, thus activating a tightly regulated gene transcription program, which leads to cell differentiation and acquisition of effector function. (jimmunol.org)
This step is essential for the recruitment of signaling effector molecules to the receptor site and their assembly into functional activation complexes. (jimmunol.org)

p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)

XP_002167107" - PREDICTED: similar to AP-4 complex subunit epsilon-1, partial [Hydra magnipapillata]. (string-db.org)

Peptides derived from proteins of the two cell populations then occur in doublets, with either 10-Da or 8-Da mass differences. (pnas.org)

The TLR4-mediated AKT activation and mitochondrial biogenesis required activation of adaptor protein MyD88 and Toll/IL-1R domain-containing adaptor-inducing IFN-β. (jimmunol.org)

Gene Ontology (GO) annotations related to this gene include protein transporter activity . (genecards.org)

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. (abnova.com)
RNAi experiments show that depletion of the clathrin adaptor AP-2 leads to increased plasma membrane expression of HIV Env and that this adaptor is required for efficient internalization mediated by both signals. (genes2cognition.org)

From NCBI Gene: This protein belongs to the aldehyde dehydrogenase family of proteins. (nih.gov)
From NCBI Gene: The protein encoded by this gene belongs to the BCL2 protein family. (nih.gov)
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. (antibodies-online.com)
SIMILARITY: Belongs to the adaptor complexes large subunit family. (univ-lyon1.fr)

Defects in formation of the complex or in its ability to interact directly with cargo inhibit enzyme uptake and lead to defective cell walls and aberrant hyphal morphology. (asm.org)
Core domains are responsible for the cargo protein binding and membrane localization. (bioscirep.org)
In the open state, both [D/E]XXXL[L/I] and YXXØ-binding sites are exposed and ready to bind to corresponding cargo proteins (yellowish circles). (bioscirep.org)

cytochrome c oxidase subunit VIIa polypep. (broadinstitute.org)

Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. (antibodies-online.com)

We identified several SNPs in the toll-like receptor 4 ( TLR4 ) and syntaxin binding protein 5-like ( STXBP5L ) loci that were associated with fibrosis risk independently of the original significant SNPs. (pubmedcentralcanada.ca)
low density lipoprotein receptor adaptor p. (broadinstitute.org)
the best characterized are the insulin receptor substrate (IRS) proteins 1-4 ( 3 ). (pnas.org)
The insulin receptor and its substrates, therefore, constitute the first critical node in the insulin signaling network ( 1 ) and thus define the full set of proteins that are tyrosine phosphorylated upon insulin stimulation and provide information that is central to determining the molecules involved in this signaling network. (pnas.org)

Anatomy7

Organisms1

Diseases4

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Psychiatry and Psychology1

Phenomena and Processes10

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Health Care2

Geographicals2

Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. (1/17)

Sigma 1- and mu 1-Adaptin homologues of Leishmania mexicana are required for parasite survival in the infected host. (2/17)

The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. (3/17)

Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. (4/17)

Mutations in the AP1S2 gene encoding the sigma 2 subunit of the adaptor protein 1 complex are associated with syndromic X-linked mental retardation with hydrocephalus and calcifications in basal ganglia. (5/17)

Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. (6/17)

AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. (7/17)

Local clustering of transferrin receptors promotes clathrin-coated pit initiation. (8/17)

Adaptor Protein Complex sigma Subunits

Adaptor Protein Complex 3

Adaptor Protein Complex 1

Sigma Factor

Adaptor Protein Complex 2

DNA-Directed RNA Polymerases

Adaptor Protein Complex 4

Adaptor Protein Complex Subunits

Adaptor Protein Complex delta Subunits

Adaptor Protein Complex mu Subunits

Adaptor Proteins, Vesicular Transport

Adaptor Protein Complex gamma Subunits

Adaptor Protein Complex beta Subunits

Adaptor Protein Complex alpha Subunits

Adaptor Proteins, Signal Transducing

California

Academies and Institutes

Mice, Knockout

National Human Genome Research Institute (U.S.)

MedlinePlus

Endosomes

trans-Golgi Network

Lysosomes

Clathrin

Mental Retardation, X-Linked

Intellectual Disability

Chromosomes, Human, X

X Chromosome

Mutation

Pedigree

Period Circadian Proteins

Cryptochromes

Germany

Flavoproteins

Photoreceptor Cells, Invertebrate

Cell Cycle Proteins

Nuclear Proteins

Hermanski-Pudlak Syndrome

Melanosomes

Molecular Sequence Data

Polymorphism, Single Nucleotide

Genotype

Taq Polymerase

Genotyping Techniques

Genetic Predisposition to Disease

Alleles

Gene Frequency

Antibodies

Antibody Specificity

Antibodies, Viral

Antibodies, Monoclonal

Antibodies, Bacterial

Antibody Formation

Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. (1/17)

Sigma 1- and mu 1-Adaptin homologues of Leishmania mexicana are required for parasite survival in the infected host. (2/17)

The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. (3/17)

Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. (4/17)

Mutations in the AP1S2 gene encoding the sigma 2 subunit of the adaptor protein 1 complex are associated with syndromic X-linked mental retardation with hydrocephalus and calcifications in basal ganglia. (5/17)

Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. (6/17)

AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. (7/17)

Local clustering of transferrin receptors promotes clathrin-coated pit initiation. (8/17)

AP1M1 QuickView - Correlation Engine

ap2m1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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