Adaptor Protein Complex sigma Subunits
Adaptor Protein Complex 1
Sigma Factor
Adaptor Protein Complex 2
DNA-Directed RNA Polymerases
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Adaptor Protein Complex 4
Adaptor Protein Complex Subunits
Adaptor Protein Complex delta Subunits
Adaptor Protein Complex mu Subunits
Adaptor Proteins, Vesicular Transport
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.
Adaptor Protein Complex gamma Subunits
Adaptor Protein Complex beta Subunits
Adaptor Protein Complex alpha Subunits
Adaptor Proteins, Signal Transducing
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. (1/17)
In the nematode Caenorhabditis elegans, there exist two micro1 medium chains of the AP-1 clathrin-associated protein complex. Mutations of unc-101, the gene that encodes one of the micro1 chains, cause pleiotropic effects (). In this report, we identified and analyzed the second mu1 chain gene, apm-1. Unlike the mammalian homologs, the two medium chains are expressed ubiquitously throughout development. RNA interference (RNAi) experiments with apm-1 showed that apm-1 and unc-101 were redundant in embryogenesis and in vulval development. Consistent with this, a hybrid protein containing APM-1, when overexpressed, rescued the phenotype of an unc-101 mutant. However, single disruptions of apm-1 or unc-101 have distinct phenotypes, indicating that the two medium chains may have distinct functions. RNAi of any one of the small or large chains of AP-1 complex (sigma1, beta1, or gamma) showed a phenotype identical to that caused by the simultaneous disruption of unc-101 and apm-1, but not that by single disruption of either gene. This suggests that the two medium chains may share large and small chains in the AP-1 complexes. Thus, apm-1 and unc-101 encode two highly related micro1 chains that share redundant and distinct functions within AP-1 clathrin-associated protein complexes of the same tissue. (+info)Sigma 1- and mu 1-Adaptin homologues of Leishmania mexicana are required for parasite survival in the infected host. (2/17)
The sorting of membrane-bound proteins from the trans-Golgi network to lysosomal/endosomal compartments is achieved by preferential inclusion into clathrin-coated vesicles. Contained within the cytoplasmic domains of such proteins, specific sequence motifs have been identified (tyrosine-based and/or di-leucine-based) that are essential for targeting and are recognized by a family of heterotetrameric adaptor complexes, which then recruit clathrin. These cytosolic protein complexes, which have been found in a wide variety of higher eukaryotic organisms, are essential for the development of multicellular organisms. In trypanosomatids, the adaptin-mediated sorting of proteins is largely uncharacterized. In order to identify components of the adaptor-complex machinery, this study reports the cloning and characterization of sigma 1- and mu 1-adaptin gene homologues from the eukaryotic protozoan parasite, Leishmania mexicana. Generation of sigma 1- and mu 1-adaptin gene deletion mutants shows that these promastigote parasites are viable in culture, but are unable to establish infection of macrophages or mice, indicating that adaptin function is crucial for pathogenesis in these unicellular organisms. (+info)The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. (3/17)
The adaptor protein (AP) complexes are involved in membrane transport of many proteins. There are 3 AP complexes in C. elegans unlike mammals that have four. To study the biological functions of the AP-3 complexes of C. elegans, we sought homologues of the mouse and human genes that encode subunits of the AP-3 complexes by screening C. elegans genomic and EST sequences. We identified single copies of homologues of the m3, s3, b3 and d genes. The medium chain of AP-3 is encoded by a single gene in C. elegans but two different genes in mammals. Since there are no known mutations in these genes in C. elegans, we performed RNAi to assess their functions in development. RNAi of each of the genes caused embryonic and larval lethal phenotypes. APM-3 is expressed in most cells, particularly strongly in spermatheca and vulva. We conclude that the products of the C. elegans m3, s3, b3 and d genes are essential for embryogenesis and larval development. (+info)Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. (4/17)
In a systematic sequencing screen of the coding exons of the X chromosome in 250 families with X-linked mental retardation (XLMR), we identified two nonsense mutations and one consensus splice-site mutation in the AP1S2 gene on Xp22 in three families. Affected individuals in these families showed mild-to-profound mental retardation. Other features included hypotonia early in life and delay in walking. AP1S2 encodes an adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of coated vesicles located at the Golgi complex. The complex mediates the recruitment of clathrin to the vesicle membrane. Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations identified in the three XLMR-affected families, and such defects may plausibly cause abnormal synaptic development and function. AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles. (+info)Mutations in the AP1S2 gene encoding the sigma 2 subunit of the adaptor protein 1 complex are associated with syndromic X-linked mental retardation with hydrocephalus and calcifications in basal ganglia. (5/17)
Fried syndrome, first described in 1972, is a rare X-linked mental retardation that has been mapped by linkage to Xp22. Clinical characteristics include mental retardation, mild facial dysmorphism, calcifications of basal ganglia and hydrocephalus. A large four-generation family in which the affected males have striking clinical features of Fried syndrome were investigated for linkage to X-chromosome markers; the results showed that the gene for this condition lies within the interval DXS7109-DXS7593 in Xp22.2. In total, 60 candidate genes located in this region, including AP1S2, which was recently shown to be involved in mental retardation, were screened for mutations. A mutation in the third intron of AP1S2 was found in all affected male subjects in this large French family. The mutation resulted in skipping of exon 3, predicting a protein with three novel amino-acids and with termination at codon 64. In addition, the first known large Scottish family affected by Fried syndrome was reinvestigated, and a new nonsense mutation, p.Gln66X, was found in exon 3. Using CT, both affected patients from the French family who were analysed had marked calcifications of the basal ganglia, as previously observed in the first Scottish family, suggesting that the presence of distinctive basal ganglia calcification is an essential parameter to recognise this syndromic disorder. It may be possible to use this feature to identify families with X-linked mental retardation that should be screened for mutations in AP1S2. (+info)Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. (6/17)
(+info)AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. (7/17)
AP17 and AP19 are the smallest polypeptide chain components of AP-2 and AP-1, the clathrin-associated protein complexes found in coated structures of the plasma membrane and Golgi apparatus of mammalian cells. cDNA clones representing the entire coding sequence of AP17 and AP19 were isolated from rat and mouse brain cDNA libraries, respectively. Determination of their nucleotide sequence predicts proteins of 142 and 158 amino acids with Mr 17,018 and 18,733. A sequence comparison of rat brain AP17 with mouse brain AP19 demonstrates that the small chains are highly related. A computer search for other related proteins has uncovered in yeast a previously unknown gene whose DNA sequence encodes a protein homologous to the small chain of AP complexes. The yeast sequence predicts Yap17p, a protein with 147 amino acids and a Mr of 17,373 that is slightly more related to the mammalian AP17 chain than to its AP19 counterpart. (+info)Local clustering of transferrin receptors promotes clathrin-coated pit initiation. (8/17)
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Sequence Similarity Search - BLAST
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AP3S2
"Entrez Gene: AP3S2 adaptor-related protein complex 3, sigma 2 subunit". Dell'Angelica, E C; Ooi C E; Bonifacino J S (Jun 1997 ... AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. AP3S2 has been shown to interact with ... Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (Apr 1997). "AP-3: an adaptor-like protein complex with ... Dell'Angelica EC, Ooi CE, Bonifacino JS (1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". J. Biol. Chem. ...
AP1S1
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
AP3S1
"Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit". Human AP3S1 genome location and AP3S1 gene details page ... AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene. GRCh38: Ensembl release 89: ... "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". ... Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex ...
AP1S2
AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene. Adaptor protein complex 1 is found at ... "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Huo L, Teng Z, Wang H, Liu X (March 2019). "A novel ... December 2006). "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked ... The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. ...
X-linked intellectual disability
AP1S2: AP-1 complex subunit sigma-2. Adaptor protein complex 1 is found on the cytoplasmic face of vesicles located at the ... "AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Entrez Gene. National Center for Biotechnology Information, U.S. ... December 2006). "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked ... This nucleolar protein is involved in the processing and modification of tRNA. GDI1: RabGDI alpha makes a complex with ...
Clathrin adaptor protein
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ... The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and ...
AP2S1
"Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit". Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat ... AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene. One of two major clathrin-associated ... Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. ... "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1-2): ...
Adaptor-related protein complex 2, alpha 1
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ...
List of adaptins
Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a ... sigma): complex 1 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 complex 2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 complex 3 AP3B1 AP3B2 ... 2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. PMC 3191125. PMID ... Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular ...
AP3M1
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the ... a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with ... "Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ...
Beta2-adaptin C-terminal domain
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
Vesicular transport adaptor protein
... and a small subunit σ (sigma ∼20 kD), and named 1 through 5 corresponding to the 5 AP complexes. Components of COPI (cop one) a ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ... but not closely related to the AP/TSET complexes. The individual proteins of the COPII complex are called SEC proteins, because ...
AP4B1
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... sigma-4 (AP4S1) AP4B1 has been shown to interact with AP4M1. AP4-complex-mediated trafficking plays a crucial role in brain ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...
AP4S1
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. The heterotetrameric adaptor protein (AP ... "Entrez Gene: adaptor-related protein complex 4". Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ... Dell'Angelica EC, Mullins C, Bonifacino JS (1999). "AP-4, a novel protein complex related to clathrin adaptors". J. Biol. Chem ...
AP4E1
AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ... sigma-4 (AP4S1). It is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... "Entrez Gene: adaptor-related protein complex 4". Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck ...
AP5S1
AP-5 complex subunit sigma (AP5S1) is a protein that in humans is encoded by the AP5S1 gene. The protein encoded by this gene ... In addition, damaging variants in the genes encoding two proteins that stably associate with the AP-5 adaptor complex are also ... Hirst, Jennifer; Irving, Carol; Borner, Georg H. H. (2012-11-21). "Adaptor protein complexes AP-4 and AP-5: new players in ... "The fifth adaptor protein complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. ISSN 1545-7885. PMC ...
FANCE
The main complex of FA contains a nuclear multi-subunit complex of notably 8 FA proteins. This adds a single ubiquiting chain ... FANCE together with FANCC acts as the substrate adapter for this reaction Activated FANCD2 protein co-localizes with BRCA1 ( ... Sigma). It also then examines the use of micro satellite markers D6S422 and D6S1610, for linking. From this, a chromosomal ... This gene encodes the protein for complementation groufcrp E. A nuclear complex containing FANCE protein (as well as FANCC, ...
List of MeSH codes (D12.776.543)
... adaptor protein complex mu subunits MeSH D12.776.543.990.150.500.750 - adaptor protein complex sigma subunits MeSH D12.776. ... adaptor protein complex alpha subunits MeSH D12.776.543.990.150.500.200 - adaptor protein complex beta subunits MeSH D12.776. ... adaptor protein complex delta subunits MeSH D12.776.543.990.150.500.400 - adaptor protein complex gamma subunits MeSH D12.776. ... adaptor protein complex 4 MeSH D12.776.543.990.150.500 - adaptor protein complex subunits MeSH D12.776.543.990.150.500.100 - ...
Centrifugation
... ribosomal subunits, plasmids, DNA, RNA and proteins in fixed-angle rotors. Compared to microcentrifuges or high-speed ... to characterize the assembly and disassembly mechanisms of biomolecular complexes, to determine subunit stoichiometries, to ... Swinging-bucket rotors tend to be used very widely because of the huge flexibility of sample size through the use of adaptors. ... "Centrifugation Separations". Sigma-Aldrich. Retrieved 23 November 2020. Brakke, Myron K. (April 1951). "Density Gradient ...
KLC1
2001). "Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of ... and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously ... 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6 ... Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene. Conventional kinesin is a tetrameric molecule ...
RICS (gene)
... a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". J. Biol. Chem. 278 (36): 34641-53 ... PX-RICS was found to be a necessary component for the export of this complex to the Golgi and then onwards to the cellular ... Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector ... and weak binding to the NR2 subunits) suggests that there may be another pathway for it modifying spine structure as well. The ...
Cingulin
Moreover, cingulin forms a complex with JAM-A, a tight junction membrane protein. Most of cingulin protein interactions are ... Aijaz S, D'Atri F, Citi S, Balda MS, Matter K (May 2005). "Binding of GEF-H1 to the tight junction-associated adaptor cingulin ... Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector ... each subunit containing a N-terminal globular "head" domain, a long α-helical coiled-coil "rod" domain and a small globular C- ...
MPD: Genes and genomic regions
protein coding gene. adaptor-related protein 5 complex, sigma 1 subunit. Tssr20255. 2. 131210363 to 131210476 113. +. TSS ... protein coding gene. heat shock protein 12B. Gm11037. 2. 131133497 to 131134215 718. +. protein coding gene. predicted gene ... protein coding gene. cell division cycle 25B. Tssr20248. 2. 131186983 to 131187001 18. +. TSS region. transcription start site ... protein coding gene. sperm flagellar 1. Tssr20245. 2. 131170945 to 131170953 8. +. TSS region. transcription start site region ...
Human C20orf29 ELISA Kit | biobool.com
DeCS
Adaptor Protein Complex sigma Subunits - Preferred Concept UI. M0404545. Scope note. A family of small adaptin protein complex ... Clathrin Assembly Protein Complex sigma Subunit. Clathrin Assembly Protein Complex sigma Subunits. Sigma Adaptins. Sigma- ... Adaptor Protein Complex sigma Subunits Descriptor Spanish: Subunidades sigma de Complejo de Proteína Adaptadora Spanish from ... Clathrin Assembly Protein Complex sigma Subunits - Narrower Concept UI. M0404773. Preferred term. Clathrin Assembly Protein ...
abnormal epididymal fat pad morphology - Ontology Report - Rat Genome Database
adaptor-related protein complex 1, sigma 2 subunit. IAGP. MGI. PMID:24928897. NCBI chr X:162,691,427...162,716,662 Ensembl chr ... FHF complex subunit HOOK interacting protein 2B. IAGP. MGI. PMID:32289885. NCBI chr14:70,820,733...70,837,309 Ensembl chr14: ... protein kinase, AMP-activated, beta 1 non-catalytic subunit. IAGP. MGI. PMID:19892703. NCBI chr 5:116,151,645...116,162,596 ... elongator complex protein 1. IAGP. MGI. PMID:26769677. NCBI chr 4:56,746,547...56,802,565 Ensembl chr 4:56,749,680...56,802,331 ...
IMP: Integrative Multi-species Prediction
adaptor-related protein complex 3, sigma 1 subunit. 0.012. CTGF. connective tissue growth factor. 0.012. ... The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a ... integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41). 0.321. ... TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa. 0.010. ...
Human Promoter Prediction
SustainPineDB
lyrata] sp,Q84WL9.1,AP2S_ARATH RecName: Full=AP-2 complex subunit sigma; AltName: Full=Adapter-related protein complex 1.4013e- ... AutoFact: AP-2 complex subunit sigma [Arabidopsis thaliana] ref,XP_002894072.1, hypothetical protein ARALYDRAFT_891585 [ ... AutoFact: Unassigned protein 1.0e-17 • FL-Next: tr=Putative uncharacterized protein; Picea sitchensis (Sitka spruce) (Pinus ... FL-Next: tr=Putative uncharacterized protein; Picea sitchensis (Sitka spruce) (Pinus sitchensis). 0.0 ...
N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss-of-Function Mice. -...
... forms a heterotetrameric complex, with AP2α, AP2β, and AP2μ subunits, that is pivotal for clathrin-mediated endocytosis, and ... AP2σ loss-of-function mutations impair internalization of the calcium-sensing receptor (CaSR), a G-protein-coupled receptor, ... The adaptor protein-2 sigma subunit (AP2σ), encoded by AP2S1, ... The adaptor protein-2 sigma subunit (AP2σ), encoded by AP2S1, ... N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss-of-Function Mice. ...
Pesquisa | Portal Regional da BVS
... adaptor related protein complex 1 sigma 2 subunit (AP1S2), PHD finger protein 21A (PHF21A), lipoma preferred partner (LPP), and ... Exosomal protein from PTECs treated with high glucose (HG) was purified and examined using liquid chromatography-tandem mass ... The CRISPR systems usually require a guide RNA (gRNA) moiety to recruit and direct the nuclease complexes. In this respect, the ... Myristoylated alanine rich protein kinase C substrate (MARCKS), epiregulin (EREG), leucine rich repeat containing 15 (LRRC15), ...
SMART: Alpha adaptinC2 domain annotation
Solution structure of the alpha adaptinC2 domain from human Adapter-related protein complex 1 gamma 2 subunit. ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ...
DeCS Ingl s
Adaptor Protein Complex sigma Subunits .. Clathrin Assembly Protein Complex sigma Subunit .. Sigma Adaptins .. Clathrin ... Adaptor Protein Complex Subunits .. Adaptor Protein Subunits .. Clathrin Assembly Protein Subunits .. 0.83. ... Adaptor Proteins, Vesicular Transport .. Adaptor Protein Complexes, Vesicular Transport .. Clathrin Adaptor Protein Complexes . ... D12.776.543.990.150.500.500 Adaptor Protein Complex mu Subunits .. D12.776.543.990.150.500.750 Adaptor Protein Complex sigma ...
GeneLoc Integrated Map for Chromosome 1: Search Results
Purified Mouse Anti-Adaptin β
The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are ... while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. β Adaptin subunits (β1, β2, β3, β4) lack sequence ... β Adaptin subunits (β1, β2, β3, β4) lack sequence homology to adaptins α, γ, δ, and ε, but all of these subunits share a ... sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes ( ...
A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit | eLife
Mih1 promotes downregulation of cell surface proteins in budding yeast by dephosphorylating a subunit of the retromer complex, ... 2002) The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late golgi membrane ... sigma), anti-His (1:1000; Biolegend) and anti-Phospho-cdc2 (Tyr15) (1:1000; Cell Signaling Technology). ... 2000) The yeast Chs4 protein stimulates the trypsin-sensitive activity of chitin synthase 3 through an apparent protein-protein ...
Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2 |...
Coffee is a complex mixture of many bioactive compounds possessing anti-inflammatory properties. However, the mechanisms by ... The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and ... 3B). This suggests the presence of negative regulators, such as protein phosphatase against the IKK complex, and that coffee ... an adaptor component of the cullin 3 (Cul3)-based ubiquitin E3 ligase complex, resulting in its proteasomal degradation37. A ...
Frontiers | SUMOylation of the Kv4.2 Ternary Complex Increases Surface Expression and Current Amplitude by Reducing...
... the amount of Kv4.2 associated with the major adaptor for constitutive CME, adaptor protein 2 (AP2), was not SUMO dependent. ... and dipeptidyl peptidase-like proteins (DPLP); multiple ancillary proteins also interact with the α-subunits throughout the ... and dipeptidyl peptidase-like proteins (DPLP); multiple ancillary proteins also interact with the alpha-subunits throughout the ... Dynamic regulation of Kv4.2 protein interactions adapts the transient potassium current, IA, mediated by Kv4 α-subunits. Small ...
IJMS | Free Full-Text | Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy...
Nedd4-2 function is furthermore regulated by cytokines, deubiquitinase Usp2-45, Ndfip adaptor proteins, 14-3-3 proteins and ... It is therefore tempting to speculate that intrinsic differences in Nav1.5 interacting proteins or accessory subunits between ... The monoclonal anti-actin antibody A7811 was purchased from Sigma-Aldrich (Sigma-Aldrich Chemie, Buchs, Switzerland) and used ... confirming the crucial role of this amino acid in the formation of a complex with WW domains. Functionally, Nedd4-2 has been ...
Cellular Caspases: New Targets for the Action of Pharmacological Agents | IntechOpen
Fas-associated DD-protein. ). The adaptor for the TNFR1 and DR3 receptors is TRADD (. TNFR1-associated DD-protein. ) (Figure 3 ... by special protein complexes: apoptosomes, PIDDosomes, DISC (. death-inducing signalling complexes. ) [7, 8]. Under certain ... Caspases can activate one another: the prodomain is cleaved from the procaspase, and the small and large subunits of the two ... The extracted RNA template was treated with DNase (Sigma, USA). The concentration and purity of the RNA template was determined ...
RCSB PDB - 7RW8: AP2 bound to heparin in the closed conformation
AP-2 complex subunit sigma. D [auth S]. 142. Mus musculus. Mutation(s): 0 Gene Names: Ap2s1, Ap17, Claps2. ... Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization.. Partlow, E.A., ... Instead, it is stimulated by endocytic pioneer proteins called muniscins, which do not enter vesicles. Muniscin-engaged AP2 is ... AP-2 complex subunit mu. C [auth M]. 435. Mus musculus. Mutation(s): 0 Gene Names: Ap2m1, Clapm1. ...
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... an adaptor protein involved in recruiting caspase-8 for activation at either the CD95 death-inducing signaling complex (DISC) ( ... Nuclei of tissue sections were stripped of proteins by incubation with 10 μg/ml proteinase K (Sigma, St. Louis, MO), 0.1 m Tris ... SK440 detects the cleaved p20 subunit of caspase-8 only (middle). SK398 (right) reacts with the p20 subunit of human caspase-8 ... 1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the ...
S-EPMC7409365 - Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. - OmicsDI
... by regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1). Thus, our study provides molecular insights into ER- ... with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice ... is an adaptor protein for the E3 ligase hydroxymethylglutaryl reductase degradation protein 1 (Hrd1) involved in endoplasmic ... with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice ...
Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption | Journal of Cell...
9). Syk, in turn, functions as an adaptor for the integrin and ITAM proteins wherein the kinase interacts with the latter in an ... The mechanisms by which c-Src exerts its effects in osteoclasts are complex. In the first instance, it functions as an adaptor ... The β3-integrin subunit is also expressed by platelets, wherein it associates with the αIIb chain. Similar to ITAM-bearing ... BMMs were infected with the virus for 24 h in the presence of 26 ng/ml MCSF and 4 μg/ml polybrene (Sigma-Aldrich). Cells were ...
Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's...
... glial fibrillary acidic protein (GFAP), gp91phox and inducible nitric oxide synthase (iNOS), were measured in the nigrostriatal ... Neuroinflammatory markers, such as ionized calcium binding adaptor molecule 1 (Iba-1), ... To confirm equal protein loading, blots were reprobed with a β-actin antibody (Sigma-Aldrich, St Louis, MO, USA) at 1:10000 ... Neuroinflammatory markers, such as ionized calcium binding adaptor molecule 1 (Iba-1), glial fibrillary acidic protein (GFAP), ...
February | 2019 | Natural Products
PTEN-null cell lines (U87 and U251 MG). However, in the SWO-38 cell line, which has wild-type PTEN protein, the level of PTEN ... The anti-FcεRI β subunit mAb (JRK) was kindly provided by Dr. J.-P. Kinet (Beth Israel Deaconess Medical Center, Boston, MA, ... ubiquitinated Ibrutinib purchase FcεRI complexes are recognized by Hrs that becomes a substrate for Syk and Cbl enzymatic ... Thus, the removal of monoubiquitinated Hrs from endosomal membrane could facilitate the clearance of the nonfunctional adapter ...
Cell/Tissue Signaling - Endocrine Pathways | Mary Lyon Centre
Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange...
PDS5 may act as a scaffolding protein and promote protein-protein interactions between adjacent cohesin complexes(Losada et al ... a motif that is involved in protein-protein interactions and is present in other cohesin subunits and regulatory factors (i.e. ... and two adapters. Two adapters were generated by annealing adapter forward and reverse primers and filled by Herculase DNA ... Bisbenzimide (2 μg/ml; Sigma) was used for nuclear staining.. Western blot analysis was performed using standard techniques ...
Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ...
The GTP-bound active state of many Gα subunits can bind a multitude of effectors and regulatory proteins. Yet it remains ... Using Gα16 as a model, we asked if its recently discovered adaptor protein tetratricopeptide repeat 1 (TPR1) binds to the same ... As the core of the G protein signal transduction machinery, the Gα subunits are required to interact with multiple partners. ... unclear if the different proteins utilize distinct or common structural motifs on the Gα subunit for binding. ...
Find Research outputs - Augusta University Research Profiles
Adaptor protein CD2AP and L-type lectin LMAN2 regulate exosome cargo protein trafficking through the Golgi complex. Kwon, S. H. ... Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal ... Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits ... Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in ...
Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission | eNeuro
... interacts with adaptor protein complex 3 (AP‐3) and regulates targeting of AP‐3 cargoes. J Neurochem 123:60-72. doi:10.1111/j. ... Utilizing whole-brain protein lysates from P0 mouse we found that immunoprecipitation of either GluA1 or GluA2 AMPAR subunits ... Sigma) supplemented with 20% FBS and NaHCO3 (4.2 mM), HEPES (1 mM; Sigma); pH 7.4. Dissected hippocampi were digested for 10 ... Neurons have evolved a number of unique protein-coding genes that regulate trafficking of protein complexes within small ...