Adaptor Protein Complex sigma Subunits: A family of small adaptin protein complex subunits of approximately 19 KDa in size.Adaptor Protein Complex 3: An adaptor protein complex found primarily on perinuclear compartments.Adaptor Protein Complex 1: A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.Sigma Factor: A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.Adaptor Protein Complex 2: An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.DNA-Directed RNA Polymerases: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).Adaptor Protein Complex 4: An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.Adaptor Protein Complex Subunits: The subunits that make up the large, medium and small chains of adaptor proteins.Adaptor Protein Complex delta Subunits: A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.Adaptor Protein Complex mu Subunits: A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.Adaptor Proteins, Vesicular Transport: A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.Adaptor Protein Complex gamma Subunits: A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.Adaptor Protein Complex beta Subunits: A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.Adaptor Protein Complex alpha Subunits: A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
(1/17) Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans.

In the nematode Caenorhabditis elegans, there exist two micro1 medium chains of the AP-1 clathrin-associated protein complex. Mutations of unc-101, the gene that encodes one of the micro1 chains, cause pleiotropic effects (). In this report, we identified and analyzed the second mu1 chain gene, apm-1. Unlike the mammalian homologs, the two medium chains are expressed ubiquitously throughout development. RNA interference (RNAi) experiments with apm-1 showed that apm-1 and unc-101 were redundant in embryogenesis and in vulval development. Consistent with this, a hybrid protein containing APM-1, when overexpressed, rescued the phenotype of an unc-101 mutant. However, single disruptions of apm-1 or unc-101 have distinct phenotypes, indicating that the two medium chains may have distinct functions. RNAi of any one of the small or large chains of AP-1 complex (sigma1, beta1, or gamma) showed a phenotype identical to that caused by the simultaneous disruption of unc-101 and apm-1, but not that by single disruption of either gene. This suggests that the two medium chains may share large and small chains in the AP-1 complexes. Thus, apm-1 and unc-101 encode two highly related micro1 chains that share redundant and distinct functions within AP-1 clathrin-associated protein complexes of the same tissue.  (+info)

(2/17) Sigma 1- and mu 1-Adaptin homologues of Leishmania mexicana are required for parasite survival in the infected host.

The sorting of membrane-bound proteins from the trans-Golgi network to lysosomal/endosomal compartments is achieved by preferential inclusion into clathrin-coated vesicles. Contained within the cytoplasmic domains of such proteins, specific sequence motifs have been identified (tyrosine-based and/or di-leucine-based) that are essential for targeting and are recognized by a family of heterotetrameric adaptor complexes, which then recruit clathrin. These cytosolic protein complexes, which have been found in a wide variety of higher eukaryotic organisms, are essential for the development of multicellular organisms. In trypanosomatids, the adaptin-mediated sorting of proteins is largely uncharacterized. In order to identify components of the adaptor-complex machinery, this study reports the cloning and characterization of sigma 1- and mu 1-adaptin gene homologues from the eukaryotic protozoan parasite, Leishmania mexicana. Generation of sigma 1- and mu 1-adaptin gene deletion mutants shows that these promastigote parasites are viable in culture, but are unable to establish infection of macrophages or mice, indicating that adaptin function is crucial for pathogenesis in these unicellular organisms.  (+info)

(3/17) The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans.

The adaptor protein (AP) complexes are involved in membrane transport of many proteins. There are 3 AP complexes in C. elegans unlike mammals that have four. To study the biological functions of the AP-3 complexes of C. elegans, we sought homologues of the mouse and human genes that encode subunits of the AP-3 complexes by screening C. elegans genomic and EST sequences. We identified single copies of homologues of the m3, s3, b3 and d genes. The medium chain of AP-3 is encoded by a single gene in C. elegans but two different genes in mammals. Since there are no known mutations in these genes in C. elegans, we performed RNAi to assess their functions in development. RNAi of each of the genes caused embryonic and larval lethal phenotypes. APM-3 is expressed in most cells, particularly strongly in spermatheca and vulva. We conclude that the products of the C. elegans m3, s3, b3 and d genes are essential for embryogenesis and larval development.  (+info)

(4/17) Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation.

In a systematic sequencing screen of the coding exons of the X chromosome in 250 families with X-linked mental retardation (XLMR), we identified two nonsense mutations and one consensus splice-site mutation in the AP1S2 gene on Xp22 in three families. Affected individuals in these families showed mild-to-profound mental retardation. Other features included hypotonia early in life and delay in walking. AP1S2 encodes an adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of coated vesicles located at the Golgi complex. The complex mediates the recruitment of clathrin to the vesicle membrane. Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations identified in the three XLMR-affected families, and such defects may plausibly cause abnormal synaptic development and function. AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles.  (+info)

(5/17) Mutations in the AP1S2 gene encoding the sigma 2 subunit of the adaptor protein 1 complex are associated with syndromic X-linked mental retardation with hydrocephalus and calcifications in basal ganglia.

Fried syndrome, first described in 1972, is a rare X-linked mental retardation that has been mapped by linkage to Xp22. Clinical characteristics include mental retardation, mild facial dysmorphism, calcifications of basal ganglia and hydrocephalus. A large four-generation family in which the affected males have striking clinical features of Fried syndrome were investigated for linkage to X-chromosome markers; the results showed that the gene for this condition lies within the interval DXS7109-DXS7593 in Xp22.2. In total, 60 candidate genes located in this region, including AP1S2, which was recently shown to be involved in mental retardation, were screened for mutations. A mutation in the third intron of AP1S2 was found in all affected male subjects in this large French family. The mutation resulted in skipping of exon 3, predicting a protein with three novel amino-acids and with termination at codon 64. In addition, the first known large Scottish family affected by Fried syndrome was reinvestigated, and a new nonsense mutation, p.Gln66X, was found in exon 3. Using CT, both affected patients from the French family who were analysed had marked calcifications of the basal ganglia, as previously observed in the first Scottish family, suggesting that the presence of distinctive basal ganglia calcification is an essential parameter to recognise this syndromic disorder. It may be possible to use this feature to identify families with X-linked mental retardation that should be screened for mutations in AP1S2.  (+info)

(6/17) Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.

 (+info)

(7/17) AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.

AP17 and AP19 are the smallest polypeptide chain components of AP-2 and AP-1, the clathrin-associated protein complexes found in coated structures of the plasma membrane and Golgi apparatus of mammalian cells. cDNA clones representing the entire coding sequence of AP17 and AP19 were isolated from rat and mouse brain cDNA libraries, respectively. Determination of their nucleotide sequence predicts proteins of 142 and 158 amino acids with Mr 17,018 and 18,733. A sequence comparison of rat brain AP17 with mouse brain AP19 demonstrates that the small chains are highly related. A computer search for other related proteins has uncovered in yeast a previously unknown gene whose DNA sequence encodes a protein homologous to the small chain of AP complexes. The yeast sequence predicts Yap17p, a protein with 147 amino acids and a Mr of 17,373 that is slightly more related to the mammalian AP17 chain than to its AP19 counterpart.  (+info)

(8/17) Local clustering of transferrin receptors promotes clathrin-coated pit initiation.

 (+info)

*  AP1S2
AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene. Adaptor protein complex 1 is found at ... "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Human AP1S2 genome location and AP1S2 gene details page ... "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation ... The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. ...
*  AP3S2
"Entrez Gene: AP3S2 adaptor-related protein complex 3, sigma 2 subunit". Dell'Angelica, E C; Ooi C E; Bonifacino J S (Jun 1997 ... AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. AP3S2 has been shown to interact with ... Dell'Angelica EC, Ooi CE, Bonifacino JS (1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". J. Biol. Chem. ... 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Dev. Cell. 5 (3): 513-21. doi:10.1016/ ...
*  AP1S1
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
*  AP3S1
"Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit". Human AP3S1 genome location and AP3S1 gene details page ... AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene. GRCh38: Ensembl release 89: ... "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". ... Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (Apr 1997). "AP-3: an adaptor-like protein complex with ...
*  X-linked intellectual disability
AP1S2: AP-1 complex subunit sigma-2. Adaptor protein complex 1 is found on the cytoplasmic face of vesicles located at the ... "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Piccini M, Vitelli F, Bruttini M, Pober BR, Jonsson JJ ... "Mutations in the Gene Encoding the Sigma 2 Subunit of the Adaptor Protein 1 Complex, AP1S2, Cause X-Linked Mental Retardation ... This nucleolar protein is involved in the processing and modification of tRNA. GDI1: RabGDI alpha makes a complex with ...
*  Adaptor-related protein complex 2, alpha 1
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ...
*  AP2S1
"Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit". Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat ... AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene. One of two major clathrin-associated ... Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. ... "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1-2): ...
*  List of adaptins
Adaptins are clustered subunits of adaptor protein (AP) complexes.. There are several types of adaptin, each related to a ... sigma): complex 1 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 complex 2 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 complex 3 AP3B1 AP3B2 ... 2011) The Fifth Adaptor Protein Complex. PLoS Biol 9(10): e1001170. doi:10.1371/journal.pbio.1001170. ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". ncbi. ...
*  Clathrin adaptor protein
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ... The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and ...
*  AP3M1
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the ... a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with ... "Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ...
*  B2-adapt-app C
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
*  Vesicular transport adaptor protein
... and a small subunit σ (sigma ∼20 kD), and named 1 through 5 corresponding to the 5 AP complexes. Components of COPI (cop one) a ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ... but not closely related to the AP/TSET complexes. The individual proteins of the COPII complex are called SEC proteins, because ...
*  AP4B1
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... sigma-4 (AP4S1) AP4B1 has been shown to interact with AP4M1. AP4-complex-mediated trafficking plays a crucial role in brain ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...
*  AP4S1
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. The heterotetrameric adaptor protein (AP ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ... Dell'Angelica EC, Mullins C, Bonifacino JS (1999). "AP-4, a novel protein complex related to clathrin adaptors". J. Biol. Chem ... adaptor-related protein complex 4". Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck G, Ekici A, ...
*  AP4E1
AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ... sigma-4 (AP4S1). It is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
*  List of MeSH codes (D12.776.543)
... adaptor protein complex mu subunits MeSH D12.776.543.990.150.500.750 -- adaptor protein complex sigma subunits MeSH D12.776. ... adaptor protein complex alpha subunits MeSH D12.776.543.990.150.500.200 -- adaptor protein complex beta subunits MeSH D12.776. ... adaptor protein complex delta subunits MeSH D12.776.543.990.150.500.400 -- adaptor protein complex gamma subunits MeSH D12.776. ... adaptor protein complex 4 MeSH D12.776.543.990.150.500 -- adaptor protein complex subunits MeSH D12.776.543.990.150.500.100 -- ...
*  Centrifugation
By 1900, it had been generally accepted that proteins were composed of amino acids; however, whether proteins were colloids or ... "Centrifugation Basics". Sigma-Aldrich. Retrieved 10 May 2016. Article on "Centrifugation" retrieved on 15 October 2013 from ... The rotors may come with different adapters to hold various sizes of test tubes, bottles, or microtiter plates. General method ... membranes and Golgi complexes can be separated by another technique called density gradient centrifugation. Ultracentrifugation ...
*  KLC1
2001). "Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of ... and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously ... 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6 ... Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene. Conventional kinesin is a tetrameric molecule ...
*  RICS (gene)
... a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". J. Biol. Chem. 278 (36): 34641-53 ... PX-RICS was found to be a necessary component for the export of this complex to the Golgi and then onwards to the cellular ... Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector ... and weak binding to the NR2 subunits) suggests that there may be another pathway for it modifying spine structure as well. The ...
*  Cingulin
Moreover, cingulin forms a complex with JAM-A, a tight junction membrane protein. Most of cingulin protein interactions are ... Aijaz S, D'Atri F, Citi S, Balda MS, Matter K (May 2005). "Binding of GEF-H1 to the tight junction-associated adaptor cingulin ... Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector ... each subunit containing a N-terminal globular "head" domain, a long α-helical coiled-coil "rod" domain and a small globular C- ...
AP2S1 (adaptor-related protein complex 2, sigma 1 subunit) - KOMP (Knockout Mouse Project)  AP2S1 (adaptor-related protein complex 2, sigma 1 subunit) - KOMP (Knockout Mouse Project)
adaptor-related protein complex 2, sigma 1 subunit. Gene nomenclature, locus information, and GO, OMIM, and PMID associations ... OMIM: HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE III; HHC3, ADAPTOR-RELATED PROTEIN COMPLEX 2, SIGMA-1 SUBUNIT; AP2S1*Gene ...
more infohttps://www.komp.org/geneinfo.php?geneid=23444
anti-AP3S1 antibody  | GeneTex  anti-AP3S1 antibody | GeneTex
... sigma 1 subunit) for ELISA, ICC/IF, IHC-P, WB. Anti-AP3S1 pAb (GTX31839) is tested in Human, Mouse samples. 100% Ab-Assurance. ... adaptor-related protein complex 3, sigma 1 subunit. Synonyms. adaptor-related protein complex 3, sigma 1 subunit Antibody , ... Primary Antibodies Secondary Antibodies Proteins & Peptides Lysates & Slides Serum & Reagents Research Kits Isotype Controls ... AP3S1 antibody is predicted to not cross-react with other AP3 protein family members. ...
more infohttp://www.genetex.com/AP3S1-antibody-GTX31839.html
WikiGenes - AP1S3 - adaptor-related protein complex 1, sigma 3...  WikiGenes - AP1S3 - adaptor-related protein complex 1, sigma 3...
AP-1 complex subunit sigma-3, Adaptor protein complex AP-1 subunit sigma-1C, Adaptor-related protein complex 1 subunit sigma-1C ... Clathrin assembly protein complex 1 sigma-1C small chain, Golgi adaptor HA1/AP1 adaptin sigma-1C subunit, ... ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound ...
more infohttps://www.wikigenes.org/e/gene/e/130340.html
Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits  Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits
Adaptor-Related Protein Complex 1 Associated Regulatory Protein ELISA Kits * Adaptor Related Protein Complex 4 sigma 1 ELISA ... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... adaptor related protein complex 2 mu 1 subunit (AP2M1) Elisa Kit * adaptor-related protein complex 2, mu 1 subunit, a (ap2m1a) ... adaptor-related protein complex 2, mu 1 subunit (Ap2m1) Elisa Kit * adaptor related protein complex 2 mu 1 subunit L homeolog ( ...
more infohttp://www.antikoerper-online.de/egfr-signaling-pathway-pathway-26/ap2m1-elisa-kit-1886/
AP4S1 (adaptor related protein complex 4 sigma 1 subunit)  AP4S1 (adaptor related protein complex 4 sigma 1 subunit)
... adaptor related protein complex 4 sigma 1 subunit), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... AP4S1 (adaptor related protein complex 4 sigma 1 subunit). Identity. Alias_names. adaptor-related protein complex 4, sigma 1 ... transporter activity clathrin-coated pit protein transporter activity protein transport endosome lumen trans-Golgi network ... transporter activity clathrin-coated pit protein transporter activity protein transport endosome lumen trans-Golgi network ...
more infohttp://atlasgeneticsoncology.org/Genes/GC_AP4S1.html
adaptor related protein complex 2 subunit sigma 1 ELISA Kits | Biocompare.com  adaptor related protein complex 2 subunit sigma 1 ELISA Kits | Biocompare.com
Compare adaptor related protein complex 2 subunit sigma 1 ELISA Kits from leading suppliers on Biocompare. View specifications ... adaptor related protein complex 2 subunit sigma 1 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well- ... Your search returned 34 adaptor related protein complex 2 subunit sigma 1 ELISA ELISA Kit across 3 suppliers. ... Watch Webinar: How To Get Speed and Depth in your Host Cell Protein (HCP) Analysis ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-2268932/ELISA_Kit/ELISA_adaptor_related_protein_complex_2_sigma_1_subunit
ap3s2 Protein, adaptor-related protein complex 3, sigma 2 subunit - Creative BioMart  ap3s2 Protein, adaptor-related protein complex 3, sigma 2 subunit - Creative BioMart
Creative Biomart offer ap3s2 proteins for life sciences research. All the products are rigorously tested to meet the most ... AP3S2;adaptor-related protein complex 3, sigma 2 subunit;AP-3 complex subunit sigma-2;sigma3b;sigma-3B-adaptin;sigma-adaptin 3b ... adaptor complex sigma3B;AP-3 complex subunit sigma-3B;clathrin-associated/assembly/adaptor protein, small 4, 22-kD;AP3S3; ... Protein Function. AP3S2 has several biochemical functions, for example, protein transporter activity. Some of the functions are ...
more infohttps://www.creativebiomart.net/symbolsearch_AP3S2.htm
AP4S1 gene - Genetics Home Reference - NIH  AP4S1 gene - Genetics Home Reference - NIH
adaptor related protein complex 4 subunit sigma 1. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ... The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin- ... This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the ...
more infohttps://ghr.nlm.nih.gov/gene/AP4S1
Produktübersicht anti-AP1S3 Antikörper  Produktübersicht anti-AP1S3 Antikörper
AP-1 complex subunit sigma-3 , adapter-related protein complex 1 sigma-1C subunit , adaptor protein complex AP-1 sigma-1C ... anti-Adaptor-Related Protein Complex 3, sigma 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 3, sigma 2 Subunit ... anti-Adaptor-Related Protein Complex 1, sigma 2 Subunit Antikörper * anti-Adaptor-Related Protein Complex 1, mu 2 Subunit ... anti-Adaptor-Related Protein Complex 2, mu 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 2, sigma 1 Subunit ...
more infohttp://www.antikoerper-online.de/abstract/AdaptorRelated+Protein+Complex+1%2C+sigma+3+Subunit+
Ap1s1 - AP-1 complex subunit sigma-1A - Mus musculus (Mouse) - Ap1s1 gene & protein  Ap1s1 - AP-1 complex subunit sigma-1A - Mus musculus (Mouse) - Ap1s1 gene & protein
The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the ... Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi ... Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi ... help/subunit_structure' target='_top'>More...,/a>,/p>Subunit structurei. Adaptor protein complex 1 (AP-1) is a heterotetramer ...
more infohttps://www.uniprot.org/uniprot/P61967
Reactome | AP2S1 [plasma membrane]  Reactome | AP2S1 [plasma membrane]
AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Plasma membrane adapto AP-2 17 kDa protein ... L1 binds to AP-2 Clathrin complex (Homo sapiens) * Clathrin:AP-2 complex [plasma membrane] (Homo sapiens) * AP-2 complex [ ... L1:AP-2 Clathrin complex [endosome] (Homo sapiens) * Clathrin:AP-2 complex [plasma membrane] (Homo sapiens) * AP-2 complex [ ... L1:AP-2 Clathrin complex [endosome] (Homo sapiens) * Clathrin:AP-2 complex [plasma membrane] (Homo sapiens) * AP-2 complex [ ...
more infohttps://reactome.org/content/detail/R-HSA-389382
Mutational analysis of the adaptor protein 2 sigma subunit (AP2S1) gene: search for autosomal dominant hypocalcemia type 3 ...  Mutational analysis of the adaptor protein 2 sigma subunit (AP2S1) gene: search for autosomal dominant hypocalcemia type 3 ...
Loss-of-function mutations of adaptor protein-2 sigma subunit (AP2σ 2), encoded by AP2S1, cause FHH3, and we therefore sought ... and G-protein subunit-α11 (GNA11) gain-of-function mutations, respectively, whereas CASR and GNA11 loss-of-function mutations ... Adaptor Protein Complex 2, Adaptor Protein Complex sigma Subunits, Adult, Child, Child, Preschool, DNA Mutational Analysis, ... Loss-of-function mutations of adaptor protein-2 sigma subunit (AP2σ 2), encoded by AP2S1, cause FHH3, and we therefore sought ...
more infohttps://www.rdm.ox.ac.uk/publications/462050
Reactome | AP2S1 [endolysosome membrane]  Reactome | AP2S1 [endolysosome membrane]
AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Plasma membrane adapto AP-2 17 kDa protein ... Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens) * Adaptor protein 2 complex [endolysosome ... Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens) * Adaptor protein 2 complex [endolysosome ... Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens) * Adaptor protein 2 complex [endolysosome ...
more infohttps://reactome.org/content/detail/R-HSA-6784821
Gene Info  Gene Info
adaptor-related protein complex 3, sigma 1 subunit. Protein Similarities Based on Shared Motif Content. ... CC] AP-3 adaptor complex *[CC] AP-type membrane coat adaptor complex *[CC] Golgi apparatus *[CC] cytoplasmic vesicle membrane * ... BP] intracellular protein transport *[BP] vesicle-mediated transport *[ ... AP3S1, adaptor-related protein complex 3, sigma 1 subunit. Sequence ID:. NM_001002924. NM_001284. ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=740519&LLNO=1176
GO Gene List  GO Gene List
Adaptor-related protein complex 2, sigma 1 subunit. NM_004069. NM_021575. Gene Info. ... PML-RARA regulated adaptor molecule 1. NM_032152. Gene Info. PRKAA1. Protein kinase, AMP-activated, alpha 1 catalytic subunit. ... Low density lipoprotein receptor adaptor protein 1. NM_015627. Gene Info. LGI3. Leucine-rich repeat LGI family, member 3. NM_ ... Mindbomb E3 ubiquitin protein ligase 1. NM_020774. Gene Info. MIB1. Mindbomb E3 ubiquitin protein ligase 1. BX648566. Gene Info ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0060627
ap1s1 TaqMan SNP Genotyping Assays
		        
	  ap1s1 TaqMan SNP Genotyping Assays
adaptor related protein complex 1 sigma 1 subunit. The protein encoded by this gene is part of the clathrin coat assembly ... adaptor related protein complex 1 sigma 1 subunit. AP19;CLAPS1;EKV3;MEDNIK;SIGMA1A. NM_001283.3. rs13225397. ... adaptor related protein complex 1 sigma 1 subunit. AP19;CLAPS1;EKV3;MEDNIK;SIGMA1A. NM_001283.3. rs2239537. ... adaptor related protein complex 1 sigma 1 subunit. AP19;CLAPS1;EKV3;MEDNIK;SIGMA1A. NM_001283.3. rs61414985. ...
more infohttps://www.thermofisher.com/order/genome-database/browse/genotyping/keyword/AP1S1
Ap1s3 - PCR Primer Pair - Probe | PrimePCR | Bio-Rad  Ap1s3 - PCR Primer Pair - Probe | PrimePCR | Bio-Rad
Adaptor-related protein complex 1, sigma 3 subunit Aliases:. Not Available. RefSeq:. Not Available. ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/qrnocip0040361-primepcr-probe-assay-ap1s3-rat
ap3s2 TaqMan SNP Genotyping Assays
		        
	  ap3s2 TaqMan SNP Genotyping Assays
C15orf38-AP3S2 readthrough;adaptor related protein complex 3 sigma 2 subunit. AP3S3;sigma3b. NM_001199058.1;NM_005829.4. rs7111 ... C15orf38-AP3S2 readthrough;adaptor related protein complex 3 sigma 2 subunit. AP3S3;sigma3b. NM_001199058.1;NM_005829.4. ... C15orf38-AP3S2 readthrough;adaptor related protein complex 3 sigma 2 subunit. AP3S3;sigma3b. NM_001199058.1;NM_005829.4. ... C15orf38-AP3S2 readthrough;adaptor related protein complex 3 sigma 2 subunit. AP3S3;sigma3b. NM_001199058.1;NM_005829.4. ...
more infohttps://www.thermofisher.com/order/genome-database/browse/genotyping/keyword/AP3S2
anti-AP3S1 antibody, N-term  | GeneTex  anti-AP3S1 antibody, N-term | GeneTex
... adaptor related protein complex 3 sigma 1 subunit) for WB. Anti-AP3S1 pAb (GTX45817) is tested in Human samples. 100% Ab- ... adaptor related protein complex 3 sigma 1 subunit. Synonyms. SIGMA3A Antibody , AP3S1 Antibody , CLAPS3 Antibody. ... Primary Antibodies Secondary Antibodies Proteins & Peptides Lysates & Slides Serum & Reagents Research Kits Isotype Controls ...
more infohttp://www.genetex.com/AP3S1-antibody-N-term-GTX45817.html
Dandy-Walker Malformation with Intellectual Disability, Basal Ganglia Disease and Seizures disease: Malacards - Research...  Dandy-Walker Malformation with Intellectual Disability, Basal Ganglia Disease and Seizures disease: Malacards - Research...
Adaptor Related Protein Complex 1 Subunit Sigma 2. Protein Coding. 18.26. GeneCards inferred via :. Publications (show sections ... Adaptor Related Protein Complex 1 Subunit Sigma 2). Affiliated tissues include brain. ...
more infohttps://www.malacards.org/card/dandy_walker_malformation_with_intellectual_disability_basal_ganglia_disease_and_seizures
AP3S2 - Wikipedia  AP3S2 - Wikipedia
"Entrez Gene: AP3S2 adaptor-related protein complex 3, sigma 2 subunit". Dell'Angelica, E C; Ooi C E; Bonifacino J S (Jun 1997 ... AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. AP3S2 has been shown to interact with ... Dell'Angelica EC, Ooi CE, Bonifacino JS (1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". J. Biol. Chem. ... 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Dev. Cell. 5 (3): 513-21. doi:10.1016/ ...
more infohttps://en.wikipedia.org/wiki/AP3S2
AP1S1 - Wikipedia  AP1S1 - Wikipedia
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
more infohttps://en.wikipedia.org/wiki/AP1S1
Recombinant Human C20orf29 293 Cell Lysate AP5S1-8117HCL - Creative BioMart  Recombinant Human C20orf29 293 Cell Lysate AP5S1-8117HCL - Creative BioMart
C20orf29; AP-5 complex subunit sigma-1; sigma5; protein C20orf29; adapter-related protein complex 5 sigma subunit. ... Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for ... Protein Labeling (optional):. -Selection-. Biotin. Fluorophores. Others. Note: There will be extra charge for optional service! ... Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min ...
more infohttps://www.creativebiomart.net/description_409768_318.htm
Gene Report for G00001927 - Genes2Cognition Neuroscience Research Programme  Gene Report for G00001927 - Genes2Cognition Neuroscience Research Programme
adaptor-related protein complex 2, sigma 1 subunit. Orthologue. G00000678 (Mus musculus). *Databases (8) ... The clathrin-associated protein complex 2 (AP-2 complex) is a group of proteins associated with clathrin-coated vesicles and ... The subunit composition of the plasma membrane adaptor complex is alpha-adaptin, beta-adaptin, AP50, and AP17; while that of ... Targeting signals and subunit interactions in coated vesicle adaptor complexes.. Page LJ and Robinson MS ...
more infohttp://www.genes2cognition.org/db/Gene/G00001927
  • AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1) AP4B1 has been shown to interact with AP4M1. (wikipedia.org)
  • AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1, this gene). (wikipedia.org)
  • We selected proteins and molecules interacted with AP3S2 here. (creativebiomart.net)
  • The most recent common ancestor (MRCA) of the eukaryotes must have had a mechanism for trafficking molecules between its endomembranes and organelles, and the likely identity of the adaptor complex involved has been reported. (wikipedia.org)
  • Thus, kinesin light chains function as adapter molecules and not motors per se. (wikipedia.org)
  • As determined by confocal microscopy, HCV proteins expressed from VT7-HCV7.9 localize largely in a globular-like distribution pattern in the cytoplasm, with some proteins co-localizing with the endoplasmic reticulum (ER) and mitochondria. (biomedcentral.com)
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • CONTEXT: Autosomal dominant hypocalcemia (ADH) types 1 and 2 are due to calcium-sensing receptor (CASR) and G-protein subunit-α11 (GNA11) gain-of-function mutations, respectively, whereas CASR and GNA11 loss-of-function mutations result in familial hypocalciuric hypercalcemia (FHH) types 1 and 2, respectively. (ox.ac.uk)
  • Loss-of-function mutations of adaptor protein-2 sigma subunit (AP2σ 2), encoded by AP2S1, cause FHH3, and we therefore sought for gain-of-function AP2S1 mutations that may cause an additional form of ADH, which we designated ADH3. (ox.ac.uk)
  • Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. (wikipedia.org)
  • This complex is composed of two large chains, a medium chain, and a small chain. (abnova.com)
  • GDI1: RabGDI alpha makes a complex with geranylgeranylated small GTP-binding proteins of the Rab family and keeps them in the cytosol. (wikipedia.org)
  • Cingulin is a homodimer, each subunit containing a N-terminal globular "head" domain, a long α-helical coiled-coil "rod" domain and a small globular C-terminal "tail" region. (wikipedia.org)
  • It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. (nih.gov)
  • Cingulin was originally discovered at the MRC Laboratory of Molecular Biology (Cambridge, UK) by Dr. Sandra Citi, as a protein present in chicken intestinal epithelial cells, that co-purified with non-muscle myosin II and was specifically localized at tight junctions (zonulae occludentes). (wikipedia.org)
  • While some of the details of how these adaptor proteins achieve their trafficking specificity has been worked out, there is still much to be learned. (wikipedia.org)
  • The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. (wikipedia.org)