A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.
An adaptor protein complex found primarily on perinuclear compartments.
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.
An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.
The subunits that make up the large, medium and small chains of adaptor proteins.
A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.
A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.
A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.
The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)
A subclass of clathrin assembly proteins that occur as monomers.
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL SURFACE RECEPTORS to MITOGEN-ACTIVATED PROTEIN KINASES.
A family of small adaptin protein complex subunits of approximately 19 KDa in size.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
Databases devoted to knowledge about specific genes and gene products.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The systematic study of the complete DNA sequences (GENOME) of organisms.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A plant genus of the family CUCURBITACEAE known for the edible fruit.
A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)
Membrane-bound compartments which contain transmitter molecules. Synaptic vesicles are concentrated at presynaptic terminals. They actively sequester transmitter molecules from the cytoplasm. In at least some synapses, transmitter release occurs by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents.
Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.
An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.
Basic functional unit of plants.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Organized activities related to the storage, location, search, and retrieval of information.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.

Phosphorylation of the medium chain subunit of the AP-2 adaptor complex does not influence its interaction with the tyrosine based internalisation motif of TGN38. (1/92)

Tyrosine based motifs conforming to the consensus YXXphi (where phi represents a bulky hydrophobic residue) have been shown to interact with the medium chain subunit of clathrin adaptor complexes. These medium chains are targets for phosphorylation by a kinase activity associated with clathrin coated vesicles. We have used the clathrin coated vesicle associated kinase activity to specifically phosphorylate a soluble recombinant fusion protein of mu2, the medium chain subunit of the plasma membrane associated adaptor protein complex AP-2. We have tested whether this phosphorylation has any effect on the interaction of mu2 with the tyrosine based motif containing protein, TGN38, that has previously been shown to interact with mu2. Phosphorylation of mu2 was shown to have no significant effect on the in vitro interaction of mu2 with the cytosolic domain of TGN38, indicating that reversible phosphorylation of mu2 does not play a role in regulating its direct interaction with tyrosine based internalisation motifs. In addition, although a casein kinase II-like activity has been shown to be associated with clathrin coated vesicles, we show that mu2 is not phosphorylated by casein kinase II implying that another kinase activity is present in clathrin coated vesicles. Furthermore the kinase activity associated with clathrin coated vesicles was shown to be capable of phosphorylating dynamin 1. Phosphorylation of dynamin 1 has previously been shown to regulate its interaction with other proteins involved in clathrin mediated endocytosis.  (+info)

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. (2/92)

Although interactions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based internalization motifs have been implicated in the selective recruitment of cargo molecules into coated pits, the functional significance of this interaction for endocytosis of many types of membrane proteins remains unclear. To analyze the function of mu2-receptor interactions, we constructed an epitope-tagged mu2 that incorporates into AP-2 and is targeted to coated pits. Mutational analysis revealed that Asp176 and Trp421 of mu2 are involved in the interaction with internalization motifs of TGN38 and epidermal growth factor (EGF) receptor. Inducible overexpression of mutant mu2, in which these two residues were changed to alanines, resulted in metabolic replacement of endogenous mu2 in AP-2 complexes and complete abrogation of AP-2 interaction with the tyrosine-based internalization motifs. As a consequence, endocytosis of the transferrin receptor was severely impaired. In contrast, internalization of the EGF receptor was not affected. These results demonstrate the potential usefulness of the dominant-interfering approach for functional analysis of the adaptor protein family, and indicate that clathrin-mediated endocytosis may proceed in both a mu2-dependent and -independent manner.  (+info)

Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. (3/92)

The apical and basolateral plasma membrane domains of polarized epithelial cells contain distinct sets of integral membrane proteins. Biosynthetic targeting of proteins to the basolateral plasma membrane is mediated by cytosolic tail determinants, many of which resemble signals involved in the rapid endocytosis or lysosomal targeting. Since these signals are recognized by adaptor proteins, we hypothesized that there could be epithelial-specific adaptors involved in polarized sorting. Here, we report the identification of a novel member of the adaptor medium chain family, named mu1B, which is closely related to the previously described mu1A (79% amino acid sequence identity). Northern blotting and in situ hybridization analyses reveal the specific expression of mu1B mRNA in a subset of polarized epithelial and exocrine cells. Yeast two-hybrid analyses show that mu1B is capable of interacting with generic tyrosine-based sorting signals. These observations suggest that mu1B may be involved in protein sorting events specific to polarized cells.  (+info)

A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. (4/92)

Although polarized epithelial cells are well known to maintain distinct apical and basolateral plasma membrane domains, the mechanisms responsible for targeting membrane proteins to the apical or basolateral surfaces have remained elusive. We have identified a novel form of the AP-1 clathrin adaptor complex that contains as one of its subunits mu1B, an epithelial cell-specific homolog of the ubiquitously expressed mu1A. LLC-PK1 kidney epithelial cells do not express mu1B and missort many basolateral proteins to the apical surface. Stable expression of mu1B selectively restored basolateral targeting, improved the overall organization of LLC-PK1 monolayers, and had no effect on apical targeting. We conclude that basolateral sorting is mediated by an epithelial cell-specific version of the AP-1 complex containing mu1B.  (+info)

mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. (5/92)

The heterotetrameric AP-1 complex is involved in the formation of clathrin-coated vesicles at the trans-Golgi network (TGN) and interacts with sorting signals in the cytoplasmic tails of cargo molecules. Targeted disruption of the mouse mu1A-adaptin gene causes embryonic lethality at day 13.5. In cells deficient in micro1A-adaptin the remaining AP-1 adaptins do not bind to the TGN. Polarized epithelial cells are the only cells of micro1A-adaptin-deficient embryos that show gamma-adaptin binding to membranes, indicating the formation of an epithelial specific AP-1B complex and demonstrating the absence of additional mu1A homologs. Mannose 6-phosphate receptors are cargo molecules that exit the TGN via AP-1-clathrin-coated vesicles. The steady-state distribution of the mannose 6-phosphate receptors MPR46 and MPR300 in mu1A-deficient cells is shifted to endosomes at the expense of the TGN. MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor.  (+info)

Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. (6/92)

HIV-1 Nef interacts with cellular adaptor protein (AP) complexes and their medium (mu) subunits. However, the role of the dileucine-based sorting motif within Nef in these interactions has been incompletely characterized. Here, yeast two-hybrid assays indicated that HIV-1 Nef interacted not only with the mu subunits of AP-1 and AP-2, but also with that of AP-3. The interactions with mu1 and mu3 were markedly stronger than the interaction with mu2. Leucine residues of the sorting motif were required for the interactions with mu3 and mu2 and contributed to the interaction with mu1. Confocal immunofluorescence microscopy indicated that Nef, AP-1, and AP-3 (but not AP-2) were concentrated in a juxtanuclear region near the cell center, potentially facilitating interaction between Nef and the mu1 and mu3 subunits. However, leucine residues of the sorting motif were not required for this subcellular localization of Nef. These data suggest that the dileucine motif, required for optimal viral replication, functions through interactions with a variety of AP complexes, including AP-3, potentially by recruiting adaptor complexes to subcellular locations specified by additional determinants in the Nef protein.  (+info)

RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. (7/92)

RLIP76 is a modular protein that was identified as a putative effector of Ral, a GTPase activated during Ras signaling. To explore further the contribution of the Ral-RLIP76 pathway to Ras signaling, we have looked for partners of RLIP76. Mu2, the medium chain of the AP2 complex is shown to interact with RLIP76. We show also that in vivo endogenous AP2 and RLIP76 form a complex and that this in vivo interaction is independent of cells being stimulated by a growth factor. Furthermore, RLIP76 differentiates AP2 from AP1 in vivo as RLIP76 differentiates mu2 from mu1 in vitro and in two hybrid assays. We show that activated Ral interferes with both tranferrin receptor endocytosis and epidermal growth factor (EGF) receptor endocytosis in HeLa cells. We propose a model where the Ral-RLIP76 pathway connects signal transduction and endocytosis through interaction on one hand between the Ras-Ral pathway and RLIP, on the other hand between RLIP and proteins belonging to the endocytotic machinery.  (+info)

Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. (8/92)

In the nematode Caenorhabditis elegans, there exist two micro1 medium chains of the AP-1 clathrin-associated protein complex. Mutations of unc-101, the gene that encodes one of the micro1 chains, cause pleiotropic effects (). In this report, we identified and analyzed the second mu1 chain gene, apm-1. Unlike the mammalian homologs, the two medium chains are expressed ubiquitously throughout development. RNA interference (RNAi) experiments with apm-1 showed that apm-1 and unc-101 were redundant in embryogenesis and in vulval development. Consistent with this, a hybrid protein containing APM-1, when overexpressed, rescued the phenotype of an unc-101 mutant. However, single disruptions of apm-1 or unc-101 have distinct phenotypes, indicating that the two medium chains may have distinct functions. RNAi of any one of the small or large chains of AP-1 complex (sigma1, beta1, or gamma) showed a phenotype identical to that caused by the simultaneous disruption of unc-101 and apm-1, but not that by single disruption of either gene. This suggests that the two medium chains may share large and small chains in the AP-1 complexes. Thus, apm-1 and unc-101 encode two highly related micro1 chains that share redundant and distinct functions within AP-1 clathrin-associated protein complexes of the same tissue.  (+info)

TY - JOUR. T1 - Inhibition of the interaction between tyrosine-based motifs and the medium chain subunit of the AP-2 adaptor complex by specific tyrphostins. AU - Crump, CM. AU - Williams, JL. AU - Stephens, DJ. AU - Banting, G. PY - 1998. Y1 - 1998. M3 - Article (Academic Journal). VL - 273. SP - 28073. EP - 28077. JO - Journal of Biological Chemistry. JF - Journal of Biological Chemistry. SN - 0021-9258. ER - ...
antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals.
antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals.
The function of the different organelles that comprise the secretory and endocytic pathways in eukaryotic cells is determined by the complement of resident proteins present within the respective organelle. The mechanisms that govern membrane protein localisation to the different organelles rely on intrinsic information in the membrane protein such as sorting motifs in the cytoplasmic domain and extrinsic factors such as coat-proteins that recognise the sorting motifs.. A well-studied example of these concepts is the sorting of membrane proteins by the clathrin-coated vesicle (CCV) adaptor proteins through recognition of the YXXΦ sorting motif. This tetra-peptide motif, comprising Tyr-X-X (where X is any amino acid)-bulky hydrophobic, is bound by the medium chain (μ) subunit of adaptor complexes resulting in the protein containing the YXXΦ motif being concentrated in CCVs (Ohno et al., 1995; Owen and Evans, 1998) (reviewed in Bonifacino and Traub, 2003). Another example of sorting motifs ...
From NCBI Gene:. The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]. From UniProt: ...
AP1S3_HUMAN] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904).[1] [AP1G1_MOUSE] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [BST2_HUMAN] IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell ...
Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves …
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
|span style=font-family:Times,serif;font-size:9pt;>The M-A251 monoclonal antibody specifically binds to the 55 kDa type I transmembrane glycoprotein known as low-affinity interleukin-2 receptor alpha chain subunit (IL-2Rα). CD25 is expressed on regulatory T cells, activated lymphocytes (T and B), and monocytes. It associates with the IL-2Rβ/CD122 and IL-2Rγ/CD132 receptor chains to form the high-affinity IL-2R complex. CD25 expression on T and B lymphocytes is upregulated by antigenic or mitogenic stimulation. Soluble CD25/IL-2Rα is produced as a consequence of lymphocyte stimulation and is found in biological fluids following inflammatory responses. |/span>
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced relatively low rates of gene gain and loss in multigene families. To investigate this possibility and to explore the phenotypic consequences of variation in gene copy number, we examined evolutionary changes in the families of genes that encode the α- and β-type subunits of hemoglobin (Hb), the tetrameric α2β2 protein responsible for blood-O2 transport. A comparative genomic analysis of 52 bird species revealed that the size and membership composition of the α- and β-globin gene families have remained remarkably constant during approximately 100 My of avian evolution. Most interspecific variation in gene content is attributable to multiple independent inactivations of the αD-globin gene, which encodes the α-chain subunit of a functionally distinct Hb isoform (HbD) that is expressed in both embryonic and definitive erythrocytes. Due to consistent differences in O2-binding properties between HbD and
The AP-complex family (Boehm and Bonifacino, 2001; Nakatsu and Ohno, 2003; Owen et al., 2004; Robinson, 2004) has six members in mammals. AP-1A, AP-2, AP-3A and AP-4 are ubiquitously expressed. The other two members, AP-5 and AP-6, are cell-type-specific isoforms of AP-1A and AP-3A: the epithelium-specific AP-1B and the neuron-restricted AP-3B.. The AP complexes consist of four subunits: one small (σ1-σ4), one medium (μ1-μ4) and two large (α, γ, δ or ϵ; and β1-β4) subunits. These assemble to form a structure in which two appendage domains are connected by flexible hinge regions to the core (Owen et al., 2004; Owen and Luzio, 2000; Robinson, 2004). The large subunits are divided into three domains: the N-terminal domain, which makes up the core with the μ and σ subunits; the hinge domain, and the C-terminal appendage. One of the large subunits (α, γ, δ or ϵ) is implicated in binding to the target membrane (Collins et al., 2002; Nakatsu and Ohno, 2003; Owen et al., 2004; Traub, ...
The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the…
ARF6 was shown early on to localize to invadopodia, specialized matrix degradative structures of tumor cells, and to be required for invadopodial activity (Hashimoto et al., 2004; Tague et al., 2004). Pioneering work identified an ARF6 pathway in which ARF6 activated by the guanine nucleotide exchange factor GEP100 at the plasma membrane is pivotal for invasion and metastasis of breast tumor-derived cell lines (Onodera et al., 2005, 2012; Hashimoto et al., 2006; Morishige et al., 2008). Here, we found that ARF6, MT1-MMP, and KIF5B kinesin-1 heavy chain subunit are abnormally overexpressed in high-grade TNBCs. To our knowledge, this is the first study reporting on dysregulation of ARF6 protein levels and its correlation with MT1-MMP in breast tumor specimens. Up-regulation of ARF6, MT1-MMP, and KIF5B in TNBCs is pathologically highly relevant given the correlation between MT1-MMP levels and tumor progression and increased metastatic potential in this subgroup of highly aggressive breast cancers ...
Current scientific tests which include ours, discovered a novel role of Rho3 in the Golgi/ endosomal trafficking, partly through bodily and/or purposeful conversation with the clathrin-associated adaptor protein-1 (AP-1) intricate and Cdc42 in fission yeast [9,10]. We also confirmed that the AP-1 complex mutant strains confirmed flaws in Golgi/ endosomal trafficking, secretion and vacuole fusion [eleven,twelve] and that Sip1, the AP-one accent recruits the AP-1 complicated to the Golgi/endosomes by figuring out the sip1-i4 mutant allele, which abolished the endosomal localization of the AP-1 complicated [13]. Sip1 is a homolog of Laa1 in the budding yeast [fourteen] and p200 in increased eukaryotes [fifteen], the two of which belong to the rising family members of AP-1 interacting associates. To realize the molecular operate of the AP-one accessory protein and elucidate the pathways interacting with Sip1/AP-one-mediated trafficking, we screened for the multi-duplicate suppressor of the ...
When released from the 20°C block, VSVG emigrated away from membranes positive for conventional Golgi to closely apposed structures that were positive for AP-1B and Exo70. Intriguingly, Exo70 also strongly localized to Tfn- and TfnR-positive recycling endosomes. Thus, it seems possible that AP-1B-dependent cargo may at least partially enter recycling endosomes before continuing to the plasma membrane after exit from the Golgi. Our data are thus in agreement with previous observations showing that Rab11 (a recycling endosome-associated GTPase) may play a role in biosynthetic traffic, at least in nonpolarized cells (Chen et al., 1998). Moreover, both the TGN and recycling endosomes are complex sorting compartments (Mellman and Warren, 2000). In the case of epithelial cells, it is also interesting to note that polarized targeting of newly synthesized and recycling glycoproteins makes use of similar or identical sorting determinants in the TGN and in the endocytic pathway (Matter et al., 1993; ...
Synonyms: cytochrome b558 subunit beta (human) superoxide-generating NADPH oxidase heavy chain subunit (human) neutrophil cytochrome b 91 kDa polypeptide (human) cytochrome b(558) subunit beta (human) gp91-1 (human) gp91-phox (human) hCYBB NADPH oxidase 2 (human) heme-binding membrane glycoprotein gp91phox (human) CGD91-phox (human) ...
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
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Katya Heldwein, PhD, Principal Investigator. Katya received her PhD from Oregon Health Sciences University in Portland, OR where she studied ligand recognition by bacterial transcription regulators using x-ray crystallography in the laboratory of Richard Brennan. She then did her postdoctoral work at Harvard Medical School in the laboratory of Stephen Harrison where she initially worked on clathrin adaptor complexes and later delved into herpesvirus cell entry. She opened her own laboratory at Tufts University School of Medicine in the Fall of 2006.. ...
In the present work, we have investigated mechanisms involved in the nucleotide-dependent regulation of clathrin-coated pit nucleation at the synapse. Our results implicate ARF6 in this process and demonstrate two effects of the GTP-bound form of this small GTPase; stimulation of the recruitment of clathrin/AP-2 to presynaptic membranes and binding plus activation of PIPKIγ. They also suggest that the two effects are related and that PI(4,5)P2 production by PIPKIγ stimulation represents the major mechanism through which ARF6 enhances clathrin/AP-2 recruitment. The action of GTP-ARF6 on clathrin/AP-2 recruitment mimics the effect of GTPγs, and its effects are antagonized by experimental manipulations that prevent either ARF activation (i.e., dominant-negative ARF6) or PI(4,5)P2 production and availability (i.e., kinase inhibition, PIPKIγ depletion, and PI(4,5)P2 hydrolysis by synaptojanins inositol 5′-phosphatase domain). These results strongly indicate that enhanced clathrin coat ...
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids. [-] ...
Mesin APM (Antrian Pasien Mandiri) , Ruang Tunggu , Ruang Periksa , Ruang Bermain Anak , Kamar Mandi , Mushola , Tempat Parkir Luas , Wifi Area , TV Digital Information , Fasilitas ...
TY - JOUR. T1 - Class I HLA folding and antigen presentation in β2- microglobulin-defective daudi cells. AU - Martayan, Aline. AU - Sibilio, Leonardo. AU - Tremante, Elisa. AU - Monaco, Elisa Lo. AU - Mulder, Arend. AU - Fruci, Doriana. AU - Cova, Agata. AU - Rivoltini, Licia. AU - Giacomini, Patrizio. PY - 2009/3/15. Y1 - 2009/3/15. N2 - To present virus and tumor Ags, HLA class I molecules undergo a complex multistep assembly involving discrete but transient folding intermediates. The most extensive folding abnormalities occur in cells lacking the class I L chain subunit, called β2-microglobulin (β2m). Herein, this issue was investigated taking advantage of eight conformational murine mAbs (including the prototypic W6/32 mAb) to mapped H chain epitopes of class I molecules, four human mAbs to class I alloantigens, as well as radioimmunoprecipitation, in vitro assembly, pulse-chase, flow cytometry, and peptide-pulse/ELISPOT experiments. We show that endogenous (HLA-A1, -A66, and -B58) as ...
Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a Novartis product and was approved by the Food and Drug Administration (FDA) in 1998. Basiliximab is an immunosuppressant agent used to prevent immediate transplant rejection in people who are receiving kidney transplants, in combination with other agents. It has been reported that some cases of lichen planus have been successfully treated with basiliximab as an alternative therapy to ciclosporin. No short-term side effects have been reported. Basiliximab competes with IL-2 to bind to the alpha chain subunit of the IL2 receptor on the surface of the activated T lymphocytes and thus prevents the receptor from signaling. This prevents T cells from replicating and also from activating B cells, which are responsible for the production of antibodies, which would bind to ...
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Function: Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis (By similarity ...
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பகல் பன்னிரண்டு மணிக்கு மீண்டும் திருச்சூரை நோக்கிப் புறப்பட்டோம். திருச்சூரைக் கடந்து குன்னங்குளம் என்ற ஊரை நோக்கி எங்கள் மகிழ்வுந்து பறந்தது. நல்ல சாலை அமைப்பு என்பதால் திட்டமிட்டதை விட வேகமாக நாங்கள் திருச்சூரைக் கடந்தோம். வழியில் அண்ணன் வீரக்குமரன் அவர்களின் விரிவுரை மகிழ்வுந்தில் அமைந்தது. முனைவர் வீரக்குமரன் அவர்கள் தமிழ், ஆங்கிலம், மலையாளம் என ...
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Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). ...
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The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
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"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... "Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules". ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
"Entrez Gene: AP4M1 adaptor-related protein complex 4, mu 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene. This gene encodes a subunit of the ... The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition ... 2001). "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4". J. Biol. Chem. 276 (16): 13145-52. ...
"Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit". Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, ... AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene. This gene encodes a subunit of the ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ...
"Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot ... AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene. This gene encodes a subunit of the ... heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This ... sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in ...
"Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... AP-3 complex subunit mu-1 is a protein that in humans is encoded by the AP3M1 gene. The protein encoded by this gene is the ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ... AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a ...
"Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting ... AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene. AP3D1 is a subunit of the AP3 adaptor- ... "Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit". CS1 maint: discouraged parameter (link) Martinez-Arca S ... Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". ...
October 2001). "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 ... The CTLA-4 protein is encoded by the Ctla4 gene in mice and the CTLA4 gene in humans. CTLA-4 was first identified in 1991 as a ... The fusion protein CTLA4-Ig is commercially available as Orencia (abatacept). A second generation form of CTLA4-Ig known as ... CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and ...
Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a ... mu), and a small adaptin (sigma): complex 1 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 complex 2 AP2A1 AP2A2 AP2B1 AP2M1 ... 2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. PMC 3191125. PMID ... Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular ...
... endosomal and the secretory pathways of integral membrane proteins by interacting with the mu subunits of the adaptor protein ( ... AP) complex. The signal-transducing adaptor protein 1 (STAP1) Src homology 2 (SH2) domain binding motif at Tyr446 - Ile450 ( ... S-palmitoylation can also modulate protein-protein interactions of SLC46A3 by changing the affinity of the protein for lipid ... NF-Y is a heterotrimeric complex of three different subunits (NF-YA, NF-YB, NF-YC) that regulates gene expression, both ...
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ... The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and ...
In molecular biology, the adaptor complexes medium subunit domain is a protein domain found at the C-terminus of the mu subunit ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ... The mu subunit regulates the coupling of clathrin lattices with particular membrane proteins by self-phosphorylation via a ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". The ...
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ...
... mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 corresponding to the 5 AP complexes. Components of COPI ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ... but not closely related to the AP/TSET complexes. The individual proteins of the COPII complex are called SEC proteins, because ...
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. The heterotetrameric adaptor protein (AP ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma ... "Entrez Gene: adaptor-related protein complex 4". CS1 maint: discouraged parameter (link) Abou Jamra R, Philippe O, Raas- ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (AP4M1), and a small ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... "Entrez Gene: adaptor-related protein complex 4". Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck ...
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly ... "Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals". The Journal ... The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals ... Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the ...
... cytosolic adaptor proteins (such as MyD88 adaptor protein) and insect and nematode Toll. Each of these groups is involved ... TIR domain present on receptor creates a heterodimer with TIR domain on accessory protein. This high affinity receptor complex ... Martin MU, Wesche H (November 2002). "Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor ... IL-1RAcP is a second receptor subunit of IL-1RI. By forming a receptor heterodimer with IL-1RI facilitates signalization due to ...
... adaptor protein complex gamma subunits MeSH D12.776.543.990.150.500.500 - adaptor protein complex mu subunits MeSH D12.776. ... adaptor protein complex alpha subunits MeSH D12.776.543.990.150.500.200 - adaptor protein complex beta subunits MeSH D12.776. ... adaptor protein complex 4 MeSH D12.776.543.990.150.500 - adaptor protein complex subunits MeSH D12.776.543.990.150.500.100 - ... adaptor protein complex 1 MeSH D12.776.543.990.150.200 - adaptor protein complex 2 MeSH D12.776.543.990.150.300 - adaptor ...
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ...
As part of a heterodimer, importin-β mediates interactions with the pore complex, while importin-α acts as an adaptor protein ... Kim IS, Kim DH, Han SM, Chin MU, Nam HJ, Cho HP, Choi SY, Song BJ, Kim ER, Bae YS, Moon YH (July 2000). "Truncated form of ... Görlich D, Kostka S, Kraft R, Dingwall C, Laskey RA, Hartmann E, Prehn S (April 1995). "Two different subunits of importin ... but the key proteins involved had not been elucidated up until that point. A 60 kDa cytosolic protein, essential for protein ...
2001). "Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system". Mol. Cell. ... Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X is a protein that in humans is encoded by ... Doublecortin is a basic protein with an iso-electric point of 10 typical of microtubule-binding proteins. In mice where the ... These domains are found in the N terminus of proteins and consists of tandemly repeated copies of an around 80 amino acids ...
... may interact directly with APC subunit APC10 and thus recruit the APC complex. CDH1 subunit of the APC complex recognizes NEDD9 ... "Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease" (Oncoscience ... Wang H, Mu X, Zhou S, Zhang J, Dai J, Tang L, Xiao L, Duan Z, Jia L, Chen S (2014). "NEDD9 overexpression is associated with ... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ...
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... Chauhan AK, Moore TL (2012). "Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human ... Chauhan AK, Moore TL (2011). "T cell activation by terminal complex of complement and immune complexes". The Journal of ...
MYPT1 is another protein phosphatase subunit that forms complexes with OGT and is itself O-GlcNAcylated. MYPT1 appears to have ... KEAP1, an adaptor protein for the cullin 3-dependent E3 ubiquitin ligase complex, mediates the degradation of NRF2; oxidative ... Mu, Changwei; Wang, Yaode; Wei, Zhongyong; Bai, Chang; Duffy, Joseph L.; McEachern, Ernest J. (Nov 2019). "Discovery of MK-8719 ... Protein phosphatase 1 subunits PP1β and PP1γ have been shown to form functional complexes with OGT. A synthetic phosphopeptide ...
Ionizable residues in the transmembrane domain of each subunit form a polar network of interactions that hold the complex ... to bind to the ITAM and activated ZAP-70 phosphorylates tyrosines on the adaptor protein LAT, which then attracts PLC-γ. Other ... The TCR complex[edit]. The TCR receptor complex is an octomeric complex of variable TCR receptor α and β chains with three ... Associated molecules of the TCR complex involved in T-cell activation[edit]. The essential function of the TCR complex is to ...
Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP ... 1995). "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex". J. Biol. Chem. 270 ( ... Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in ... Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene. Interleukin 1 induces ...
... forming a complex called Small Latent Complex (SLC). This complex remains in the cell until it is bound by another protein ... "TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation". Nature Cell Biology. 3 (8 ... Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, et al. (April 2002). "The integrin alpha(v)beta8 mediates ... TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor ...
Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many ... G-protein coupled receptor signaling pathway. • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway. • G- ... clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2 unable to mobilize ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...
Signal transducing adaptor protein. *Scaffold protein. Transcription factors. *General. *Transcription preinitiation complex ... They have a heteromeric structure in that each subunit consists of the extracellular ligand-binding domain and a transmembrane ... and can be a protein or peptide (short protein), or another small molecule such as a neurotransmitter, hormone, pharmaceutical ... In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.[1] When ...
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... Chauhan, A. K., and Moore, T. L. (2012) Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... Chauhan, A. K., and Moore, T. L. (2011) T cell activation by terminal complex of complement and immune complexes. The Journal ...
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
adapter-related protein complex 5 mu subunit. adapter-related protein complex 5 subunit mu-1. adaptor related protein complex 5 ... AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo sapiens] AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo ... AP-5 complex subunit mu-1. Names. AP-5 complex subunit mu. MHD domain-containing death-inducing protein. MU-2/AP1M2 domain ... adaptor related protein complex 5 subunit mu 1provided by HGNC. Primary source. HGNC:HGNC:20192 See related. Ensembl: ...
adaptor protein complex AP-1 mu-2 subunit. adaptor related protein complex 1 mu 2 subunit. clathrin assembly protein complex 1 ... AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens] AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo ... clathrin-associated adaptor medium chain mu2. golgi adaptor AP-1 47 kDa protein. golgi adaptor HA1/AP1 adaptin mu-2 subunit. mu ... General protein information Go to the top of the page Help Preferred Names. AP-1 complex subunit mu-2. Names. AP-mu chain ...
Compare adaptor related protein complex 3 subunit mu 1 ELISA Kits from leading suppliers on Biocompare. View specifications, ... adaptor related protein complex 3 subunit mu 1 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used ... Your search returned 14 adaptor related protein complex 3 subunit mu 1 ELISA ELISA Kit across 2 suppliers. ... Watch Webinar: How To Get Speed and Depth in your Host Cell Protein (HCP) Analysis ...
... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... anti-Adaptor-Related Protein Complex 1, mu 2 Subunit Antibodies * anti-Adaptor-Related Protein Complex 1, mu 1 Subunit ... anti-Adaptor-Related Protein Complex 3, mu 1 Subunit Antibodies * anti-Adaptor-Related Protein Complex 3, mu 2 Subunit ... anti-Adaptor-Related Protein Complex 4, mu 1 Subunit Antibodies * anti-Adaptor-Related Protein Complex 5, mu 1 Subunit ...
... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... AP-2 complex subunit mu-1-A , AP-2 complex subunit mu-A , AP-2 mu-2 chain A , AP-2 mu-A chain , adaptor protein complex AP-2, ... adaptor related protein complex 2 mu 1 subunit (AP2M1) Elisa Kit * adaptor-related protein complex 2, mu 1 subunit, a (ap2m1a) ... adaptor-related protein complex 2, mu 1 subunit (Ap2m1) Elisa Kit * adaptor related protein complex 2 mu 1 subunit L homeolog ( ...
Adaptor protein complex AP-2 subunit mu explanation free. What is Adaptor protein complex AP-2 subunit mu? Meaning of Adaptor ... protein complex AP-2 subunit mu medical term. What does Adaptor protein complex AP-2 subunit mu mean? ... Looking for online definition of Adaptor protein complex AP-2 subunit mu in the Medical Dictionary? ... Adaptor protein complex AP-2 subunit mu , definition of Adaptor protein complex AP-2 subunit mu by Medical dictionary https:// ...
Protein Coding), Adaptor Related Protein Complex 4 Mu 1 Subunit, including: function, proteins, disorders, pathways, orthologs ... AP4M1 (Adaptor Related Protein Complex 4 Mu 1 Subunit) is a Protein Coding gene. Diseases associated with AP4M1 include Spastic ... AP4M1 Gene(Protein Coding) Adaptor Related Protein Complex 4 Mu 1 Subunit. ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ...
Protein Coding), Adaptor Related Protein Complex 3 Mu 1 Subunit, including: function, proteins, disorders, pathways, orthologs ... AP3M1 (Adaptor Related Protein Complex 3 Mu 1 Subunit) is a Protein Coding gene. Among its related pathways are Chaperonin- ... AP3M1 Gene(Protein Coding) Adaptor Related Protein Complex 3 Mu 1 Subunit. ... Protein Symbol:. Q9Y2T2-AP3M1_HUMAN. Recommended name:. AP-3 complex subunit mu-1 Protein Accession:. Q9Y2T2. Secondary ...
... mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP) ... AP-4 complex subunit mu-1. A. 301. Homo sapiens. Mutation(s): 2 Gene Names: AP4M1 (MUARP2). ... Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the ... Sorting of the Alzheimers disease amyloid precursor protein mediated by the AP-4 complex.. Burgos, P.V., Mardones, G.A., Rojas ...
... of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in ... Adaptor Protein Complex mu Subunits / chemistry * Adaptor Protein Complex mu Subunits / metabolism ... Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo- ... protein synaptotagmin 1. The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin ...
AP1-mu2 anti-HSMU1B anti-MU-1B anti-MU1B anti-mu2 and related products to AP1M2, AP1-mu2, HSMU1B, MU-1B, MU1B, mu2 ... adaptor protein complex AP-1 mu-2 subunit,adaptor related protein complex 1 mu 2 subunit,clathrin assembly protein complex 1 mu ... AP1M2: adaptor related protein complex 1 subunit mu 2. AP1-mu2, HSMU1B, MU-1B, MU1B, mu2. Summary. This gene encodes a subunit ... clathrin-associated adaptor medium chain mu2,golgi adaptor AP-1 47 kDa protein,golgi adaptor HA1/AP1 adaptin mu-2 subunit,mu- ...
Adaptor Protein Complex mu Subunits / metabolism * Arabidopsis / genetics* * Arabidopsis / metabolism* * Brefeldin A / ... Co-immunoprecipitation experiments show that hTfR is able to interact with a mu-adaptin subunit from Arabidopsis cytosol, a ... inhibits the interaction between the YTRF endocytosis signal in the hTfR cytosolic tail and the mu2-subunit of the AP2 complex ...
Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor ... The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting ... Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and ... but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Tyr-156 in membrane- ...
Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor ... Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and ... The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface ... but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane- ...
... adaptor protein complex AP-1 mu-1 subunit , adaptor-related protein complex 1 mu-1 subunit , clathrin adaptor protein AP47 , ... anti-Adaptor-Related Protein Complex 3, mu 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 3, mu 2 Subunit ... anti-Adaptor-Related Protein Complex 4, mu 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 5, mu 1 Subunit ... adaptor-related protein complex 1, mu 1 subunit (Ap1m1) Antikörper * adaptor-related protein complex AP-1, mu subunit 1 (Ap1m1 ...
adaptor-related protein complex 2, mu 1 subunit [Source:HGNC Symbol;Acc:564]. Mouse Orthologue:. Ap2m1. Mouse Description:. ... AP-2 complex subunit mu-1-A [Source:UniProtKB/Swiss-Prot;Acc:Q6NWK2]. Human Orthologue:. AP2M1. Human Description:. ... adaptor protein complex AP-2, mu1 Gene [Source:MGI Symbol;Acc:MGI:1298405]. ...
adaptor-related protein complex 3, mu 2 subunit. MGI:1929214 1 matching records from 1 references.. Summary by Age and Assay: ... Ap3m2 adaptor-related protein complex 3, mu 2 subunit (Synonyms: 5830445E16Rik, AP-3B) ...
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... "Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules". ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
adaptor-related protein complex AP-1, mu subunit 1. MGI:102776 Go Annotations as Summary Text (Tabular View) (GO Graph). ... adaptor related protein complex 1 subunit mu 1).. Go Annotations in Tabular Form (Text View) (GO Graph) Filter annotations by: ...
adaptor-related protein complex 3, mu 1 subunit. 6169822. Full Length. BC067127. adaptor-related protein complex 3, mu 1 ... BP] protein targeting to lysosome *[CC] Golgi apparatus *[CC] clathrin adaptor complex *[CC] lysosome *[MF] protein binding ... Protein Similarities Based on Shared Motif Content. Find gene products sharing protein motifs with: NP_036227 NP_996895 Protein ... AP3M1, adaptor-related protein complex 3, mu 1 subunit. Sequence ID:. NM_012095. NM_207012. ...
The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... Adaptor related protein complex 1 mu 1 subunit. Protein classi. Protein class the gene product belongs to according to selected ... AP-1 complex subunit mu-1 A0A024R7K8 [Target identity:100%; Query identity:100%]. Adaptor-related protein complex 1, mu 1 ... Adaptor related protein complex 1 mu 1 subunit (HGNC Symbol). Entrez gene summary. The protein encoded by this gene is the ...
Adapter-related protein complex 3 mu-1 subunit antibody. *AP-3 adapter complex mu3A subunit antibody ... Belongs to the adaptor complexes medium subunit family.. Contains 1 MHD (mu homology) domain. ... Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi ... The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/ ...
"Entrez Gene: AP4M1 adaptor-related protein complex 4, mu 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene. This gene encodes a subunit of the ... The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition ... 2001). "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4". J. Biol. Chem. 276 (16): 13145-52. ...
Adaptor-related protein complex 2, mu 1 subunit. NM_004068. NM_001025205. Gene Info. ... Adaptor-related protein complex 2, alpha 2 subunit. NM_001242837. NM_012305. Gene Info. ... ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9). NM_005175. NM_001002027. Gene Info. ... ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9). NM_001002031. NM_005176. Gene Info. ...
adaptor-related protein complex 2, mu 1 subunit. *AP-2 mu chain ... Plasma membrane adaptor AP-2 50 kDa protein. *plasma membrane ... Recombinant protein fragment corresponding to amino acids 97-383 of human AP2M1 (NP_001020376) produced in E.coli. ... Clathrin assembly protein complex 2 medium chain. *clathrin coat adaptor protein AP50 ... Clathrin coat assembly protein AP50. *Clathrin coat-associated protein AP50. *clathrin-associated/assembly/adaptor protein, ...
adaptor related protein complex 3 mu 2 subunit. Alias. entrezgene 549404 entrezgene 549404 ...
Adaptor-related protein complex 2, mu 1 subunit Assay Type: SYBR® Green Assay Design: Exonic Application: Gene Expression ... Adaptor-related protein complex 2, mu 1 subunit Assay Type: Probe Assay Design: Exonic Application: Gene Expression Unique ... The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease ...
adaptor-related protein complex 4, mu 1 subunit. Aliases:. CPSQ3, MU-4, MU-ARP2. ... The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition ... This gene encodes a subunit of the heterotetrameric AP-4 complex. ... and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [ ...
adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.169770. 7.812. 2 Whole brain. AD-cases-controls. GSE5281 Human Brain ... adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.346075. 13.696. 1 Whole brain. AD-cases-controls. GSE5281 Human ... adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.169697. 10.808. 3 Whole brain. AD-cases-controls-Myers. GSE15222 ... adaptor-related protein complex 1, mu 1 subunit; 3 UTR. Chr19: 16.207086. -0.780. ...
Gene Name: adaptor related protein complex 2 mu 1 subunit Synonyms: clapm1 Add Xenopus synonyms , Nomenclature history Gene ... NM_001087334,Xenopus laevis adaptor related protein complex 2 mu 1 subunit L homeolog (ap2m1.L), mRNA ... NM_203644,Xenopus tropicalis adaptor related protein complex 2 mu 1 subunit (ap2m1), mRNA ... Protein Refseq ,NP_988975,AP-2 complex subunit mu [Xenopus tropicalis] ...
  • We identify dynamin and the EAP -binding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in clathrin mediated endocytosis. (antikoerper-online.de)
  • Co-immunoprecipitation experiments show that hTfR is able to interact with a mu-adaptin subunit from Arabidopsis cytosol, a process that is blocked by tyrphostin A23. (nih.gov)
  • The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. (wikipedia.org)
  • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1 ), a medium adaptin (mu-type subunit AP1M1 or AP1M2 ) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3 ). (rcsb.org)
  • AP1M1, also named as CLTNM, Mu-adaptin 1 and Clathrin coat assembly protein AP47, belongs to the adaptor complexes medium subunit family. (ptglab.com)
  • This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. (antibodies-online.com)
  • The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). (antibodies-online.com)
  • Beta adaptin is a subunit of the plasma membrane CC adaptor (By similarity). (univ-lyon1.fr)
  • SUBUNIT: Adaptor protein complex 2 (AP-2) is a heterotetramer CC composed of two large adaptins (alpha-type subunit apl3 and beta- CC type subunit apl1), a medium chain (mu-type subunit apm4) and a CC small adaptin (sigma-type subunit aps2). (univ-lyon1.fr)
  • This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. (thermofisher.com)
  • Adaptin subunits recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal appendage domains. (embl.de)
  • By contrast, GGAs are monomers composed of four domains, which have functions similar to AP subunits: an N-terminal VHS (Vps27p/Hrs/Stam) domain, a GAT (GGA and Tom1) domain, a hinge region, and a C-terminal GAE (gamma-adaptin ear) domain. (embl.de)
  • Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). (icr.ac.uk)
  • Also known as AP-3 complex subunit beta (Adaptor protein complex AP-3 beta subunit) (Adaptor-related protein complex 3 subunit beta) (Beta-3-adaptin) (Clathrin assembly protein complex 3 beta large chain). (mybiosource.com)
  • Also known as AP-3 complex subunit delta (Adaptor-related protein complex 3 subunit delta) (Delta-adaptin 3) (Delta-adaptin). (mybiosource.com)
  • Also known as AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (BLVPCP1) (Bovine leukemia virus cell receptor) (BLV-R) (Delta-adaptin). (mybiosource.com)
  • Also known as AP-3 complex subunit mu (Adaptor protein complex AP-3 subunit mu) (Adaptor protein-3 mu-adaptin) (Adaptor-related protein complex 3 subunit mu) (At-muD-Ad) (Mu3-adaptin) (Protein ZIG SUPPRESSOR 4). (mybiosource.com)
  • We report here that HAPLESS13 (HAP13), the Arabidopsis µ1 adaptin, is essential for protein sorting at the TGN / EE . (plantphysiol.org)
  • 171 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) Antibodies from 23 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
  • Auf www.antikoerper-online.de finden Sie aktuell 17 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits von 5 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Recombinant protein fragment corresponding to amino acids 97-383 of human AP2M1 (NP_001020376) produced in E.coli. (novusbio.com)
  • Additionally, it was demonstrated that ALT inhibited cell proliferation, colony formation, autophagy, induced apoptosis and reduced tumor growth in vivo through upregulating the expression of adaptor related protein complex 2 subunit mu 1 (AP2M1). (biomedcentral.com)
  • AP2M1 encodes the μ-subunit of the adaptor protein complex 2 (AP-2), which belongs to the adaptor complexes medium subunits family. (biomedcentral.com)
  • AP2M1 is one of the most important cytoplasmic carrier domains in clathrin-mediated endocytosis, and phosphorylation of this subunit stimulates clathrin and supports cell surface receptor incorporation. (biomedcentral.com)
  • Recombinant protein fragment corresponding to a region within amino acids 1 and 160 of Human AP2M1. (abcam.co.jp)
  • Cell surface expression of hTfR increases upon treatment with tyrphostin A23, which inhibits the interaction between the YTRF endocytosis signal in the hTfR cytosolic tail and the mu2-subunit of the AP2 complex. (nih.gov)
  • Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. (nih.gov)
  • AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. (uniprot.org)
  • AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. (uniprot.org)
  • Accessory protein recruitment motifs in clathrin-mediated endocytosis. (eu.org)
  • As a generalization, class I and II Arfs mainly localize to the trans-Golgi network (TGN), endoplasmic reticulum-Golgi intermediate complex (ERGIC) and Golgi apparatus to mediate membrane trafficking between these compartments, whereas the class III Arf6 localizes to the plasma membrane and is involved in endocytosis ( 2-4 ). (bioscience.org)
  • The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway. (ox.ac.uk)
  • These results suggest the surface expression of KIAA0319 is regulated by endocytosis, supporting the idea that the internalization and recycling of the protein may be involved in fine tuning its role in neuronal migration. (ox.ac.uk)
  • Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. (ucsc.edu)
  • AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:14745134, PubMed:15473838). (icr.ac.uk)
  • Clathrin-mediated endocytosis is a major pathway by which proteins and membrane components are internalized into cells. (rupress.org)
  • The complex binds polyphosphoinositide-containing lipids. (xenbase.org)
  • The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppO sorting signals at distinct sites. (eu.org)
  • Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (uniprot.org)
  • The LIS1 accessory protein directly binds dynein, although its precise role in regulating dynein remains unclear. (sdbonline.org)
  • We recently found that, instead, the mu4 subunit of AP-4 binds an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP). (grantome.com)
  • Motif conserving the exact sequence KEN that binds to the APC/C subunit Cdh1 causing the protein to be targeted for 26S proteasome mediated degradation. (eu.org)
  • This degron motif is present in JAZ transcriptional repressor proteins and binds to the COI1 F-box protein of the SCF E3 ubiquitin ligase in a jasmonate-dependent manner. (eu.org)
  • Adaptor protein 4 (AP-4) is the most recently discovered and least well-characterized member of the family of heterotetrameric adaptor protein (AP) complexes that mediate sorting of transmembrane cargo in post-Golgi compartments. (rcsb.org)
  • This is the case for the subunits of the heterotetrameric adaptor protein complex 4 (AP-4). (biomedcentral.com)
  • The family of heterotetrameric adaptor protein (AP) complexes function as vesicle coat components, involved in targeting cargo proteins from post-Golgi compartments to the endosomal-lysosomal system. (reactome.org)
  • Results indicate that AP-2 is not essential for clathrin -coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins. (antikoerper-online.de)
  • Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. (genecards.org)
  • Stonins--specialized adaptors for synaptic vesicle recycling and beyond? (nih.gov)
  • Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves as a linker between the endocytic proteins AP-2 and Eps15 and the calcium-sensing synaptic vesicle (SV) protein synaptotagmin 1. (nih.gov)
  • Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. (uniprot.org)
  • This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. (wikipedia.org)
  • The AP4M1 belongs to a complex that mediates vesicle trafficking of glutamate receptors, being likely involved in brain development and neurotransmission. (biomedcentral.com)
  • Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:14745134, PubMed:15473838). (icr.ac.uk)
  • Current work in our laboratory is aimed at elucidating the structure, regulation and physiological roles of coat proteins and vesicle tethering factors, and investigating human diseases that result from genetic defects (e.g. (grantome.com)
  • Adaptor proteins (APs) play key roles in this process by recruiting coat proteins and selecting cargos for different vesicle carriers. (plantphysiol.org)
  • Our study reveals the utility of proteomics in the identification of novel vesicle trafficking proteins. (rupress.org)
  • A variety of interactions between Ca 2+ channels and presynaptic proteins contribute to the molecular and mechanistic complexities of the vesicle release cycle and synaptic transmission ( Sudhof, 1995 ). (biologists.org)
  • These findings demonstrate that APP and AP-4 engage in a distinct type of signal-adaptor interaction that mediates transport of APP from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. (rcsb.org)
  • The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. (abcam.com)
  • AP-1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. (vwr.com)
  • In previous work, we found that a complex named GARP is a critical component of the molecular machinery that mediates retrograde transport of various cargo proteins, including sorting receptors, processing endopeptidases, fusogenic proteins and bacterial and plant toxins, from endosomes to the trans-Golgi network in mammalian cells. (grantome.com)
  • This short C-terminal motif is present in co-activators, the Doc1/APC10 subunit and some substrates of the APC/C and mediates direct binding to TPR-containing APC/C core subunits. (eu.org)
  • Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network. (nih.gov)
  • This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. (genecards.org)
  • AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). (genecards.org)
  • The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. (genecards.org)
  • AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. (genecards.org)
  • The complex is associated with the Golgi region as well as more peripheral structures. (genecards.org)
  • The protein encoded by AP1M1 is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. (antikoerper-online.de)
  • In the course of HCV protein production, there is disruption of the Golgi apparatus, loss of spatial organization of the ER, appearance of some "virus-like" structures and swelling of mitochondria. (biomedcentral.com)
  • AP3 plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes by facilitating budding of vesicles from the Golgi membrane. (thefreedictionary.com)
  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. (rcsb.org)
  • Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (embl.de)
  • It can therefore bind to AP4M1 of the AP4 complex and subsequently, be transported from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. (reactome.org)
  • The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. (utsouthwestern.edu)
  • The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. (utsouthwestern.edu)
  • The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (uniprot.org)
  • the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (uniprot.org)
  • We showed that the molecular function of this complex is to promote tethering and fusion of endosome-derived transport carriers to the trans-Golgi network. (grantome.com)
  • Interference with any of the GARP subunits blocks the delivery of many cargos to the trans-Golgi network, leading to global defects in lysosomal function, lipid traffic and autophagy. (grantome.com)
  • Enthoprotin interacts with the clathrin adaptors AP1 and with Golgi-localized, γ-ear-containing, Arf-binding protein 2. (rupress.org)
  • Furthermore, super-resolution imaging identified that the Nef:MHC-I BiFC complex transits through both early and late endosomes before ultimately residing at the trans-Golgi network. (nature.com)
  • The first model, termed the signaling mode of downregulation, is activated early during infection and involves the targeting of Nef to the trans-Golgi network (TGN) by the host membrane trafficking regulator protein phosphofurin acidic cluster sorting protein 2 (PACS-2) 2 , 7 . (nature.com)
  • The basic patch on micro1 that interacts with the Nef acidic cluster also contributes to the binding of endogenous acidic cluster proteins. (antikoerper-online.de)
  • In addition, we find that AP-1 interacts with Tsg101 and Nedd4.1, two cellular proteins known to be involved in HIV-1 and MLV budding. (cnrs.fr)
  • The Yxxphi motif interacts with mu subunit of AP (Adaptor Protein) complex. (eu.org)
  • Disclosed is a method for improving folding efficiency and solubility of a target protein linked to a RNA-binding protein by using RNA molecule as a molecular chaperone, wherein the RNA molecule interacts with the RNA-binding protein. (justia.com)
  • Here, we show that HRSV Matrix (M) protein interacts with the cellular adaptor protein complex 3 specifically via its medium subunit (AP-3Mu3A). (missouristate.edu)
  • The gene encoding the protein MUDENG (Mu-2 related death-inducing gene) was cloned and characterized. (nih.gov)
  • This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. (nih.gov)
  • This gene encodes a subunit of the heterotetrameric AP-4 complex. (genecards.org)
  • AP4M1 (Adaptor Related Protein Complex 4 Mu 1 Subunit) is a Protein Coding gene. (genecards.org)
  • AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. (wikipedia.org)
  • AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene. (wikipedia.org)
  • Antigen standard for MU-2/AP1M2 domain containing, death-inducing (MUDENG), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
  • A gene on chromosome 19p13.12 that encodes a medium subunit of the heterotetrameric AP3 complex, an adaptor-related protein complex composed of two large subunits (delta and beta), a medium subunit (mu), and a small subunit (sigma). (thefreedictionary.com)
  • The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. (antibodies-online.com)
  • This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. (antibodies-online.com)
  • This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. (antibodies-online.com)
  • An important gene associated with Generalized Epilepsy with Febrile Seizures Plus is SCN1B (Sodium Voltage-Gated Channel Beta Subunit 1), and among its related pathways/superpathways are Developmental Biology and G-Beta Gamma Signaling . (malacards.org)
  • This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. (ucsc.edu)
  • Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. (ucsc.edu)
  • A single Select transcript is chosen as representative for each protein-coding gene. (ucsc.edu)
  • The cDNA sequences are enriched in the following gene ontology functional categories: protein binding, hydrolase, transferase, and catalytic enzymes. (biomedcentral.com)
  • The FLCN gene encodes the protein folliculin (FLCN) which is 579 amino acids in length and has a mass of 64 kDa in humans. (frontiersin.org)
  • Among the ten novel proteins identified is the rat homologue of a predicted gene product from human, mouse, and Drosophila genomics projects, which we named enthoprotin. (rupress.org)
  • It may also play a role in regulating the intracellular trafficking and function of CTLA-4 protein. (thefreedictionary.com)
  • Intracellular traffic of many membrane-bound proteins requires sequences facing the cytoplasm. (eu.org)
  • Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. (antibodies-online.com)
  • However, E. coli has a severe disadvantage in terms of not having a variety of intracellular elements required for maturation of proteins in comparison with eukaryotic cells. (justia.com)
  • This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. (utsouthwestern.edu)
  • Further analysis of the subcellular distribution of the overexpressed protein in mammalian cells indicates that KIAA0319 can colocalize with the early endosomal marker early endosome antigen 1 (EEA1) in large intracellular vesicles, suggesting that it is endocytosed. (ox.ac.uk)
  • In the current report, we utilized the intracellular protein-protein interaction reporter system, bimolecular fluorescence complementation (BiFC), in combination with super-resolution microscopy, to track the Nef/MHC-I interaction and determine its subcellular localization in cells. (nature.com)
  • Recombinant funsion protein containing a sequence corresponding to amino acids 164-423 of human AP1M2 (NP_005489.2). (genetex.com)
  • AP1M2 is a subunit of the adaptor complex AP-1. (vwr.com)
  • Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells. (nih.gov)
  • Herein, we report the interaction of an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP) with the mu4 subunit of AP-4. (rcsb.org)
  • IRS-1 (zeige IRS1 Antikörper ) associates with mu1A of the ubiquitously expressed AP-1 (zeige FOSB Antikörper ) complex through three protein interaction motifs. (antikoerper-online.de)
  • We show that the AP-1 complex facilitates retroviral budding through a direct interaction between the matrix and AP-1mu. (cnrs.fr)
  • Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit. (eu.org)
  • The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4(+) T cell apoptosis. (ptglab.com)
  • We demonstrate that this interaction is mediated by the AP-2 mu subunit (Apm4) YXXΦ binding domain. (asm.org)
  • Interaction of the human respiratory Syncytial virus matrix protein wi" by Casey Ward, Maciej Maselko et al. (missouristate.edu)
  • This novel protein-protein interaction was first detected via yeast-two hybrid screen and was further confirmed in a mammalian system by immunofluorescence colocalization and co-immunoprecipitation. (missouristate.edu)
  • This novel interaction is further substantiated by the presence of a known tyrosine-based adaptor protein MU subunit sorting signal sequence, YXXФ: where Ф is a bulky hydrophobic residue, which is conserved across the related RSV M proteins. (missouristate.edu)
  • This degron overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4 Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. (eu.org)
  • This degron, occurring in non-Vertebrates, overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4 Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. (eu.org)
  • Zusätzlich bieten wir Ihnen AP1M1 Kits (20) und AP1M1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • Orthologous to human AP1M1 (adaptor related protein complex 1 subunit mu 1). (jax.org)
  • AP1M1 (NP_115882, 1 a.a. ~ 74 a.a) partial recombinant protein with GST tag. (proteogenix-products.com)
  • Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, l. (xenbase.org)
  • The Yxxphi motif is a sorting signal found in the cytosolic tail of various membrane proteins as an endocytic motif and also directs traffic within the endosomal and the secretory pathways. (eu.org)
  • Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. (vwr.com)
  • Failure to localize membrane proteins to the primary cilium causes a group of diseases collectively named ciliopathies. (biologists.org)
  • The medium (mu) adaptins of all AP complexes can recognise and interact with tyrosine-based (YXXphi) sorting signals found within the cytoplasmic tails of integral membrane proteins (Aguilar et al. (reactome.org)
  • All AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). (embl.de)
  • This entry represents the small sigma and mu subunits of various adaptins from different AP clathrin adaptor complexes (including AP1, AP2, AP3 and AP4), and the zeta and delta subunits of various coatomer (COP) adaptors. (embl.de)
  • The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. (uniprot.org)
  • The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (rcsb.org)
  • Sorting is mediated by recognition of signals present in the cytosolic domains of the transmembrane proteins by adaptor proteins that are components of membrane coats (e.g., clathrin coats). (grantome.com)
  • Assembly Protein Complex 2 Human Recombinant produced in E.Coli is a non-glycosylated, polypeptide chain containing amino acids (1-435) and having a total molecular mass of 50 kDa. (promab.com)
  • V1H can function as an adaptor for interactions between Nef and AP-2 (zeige GTF3A ELISA Kits ). (antikoerper-online.de)
  • Biochemical and X-ray crystallographic analyses reveal that the properties of the APP sequence and the location of the binding site on mu4 are distinct from those of other signal-adaptor interactions. (rcsb.org)
  • The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
  • RGS9-2 acts via a complex mechanism that involves interactions with Gα subunits, the Gβ5 protein, and the adaptor protein R7BP. (sigmaaldrich.com)
  • To date, knowledge of viral and host protein interactions within HRSV is limited and are critical areas of research. (missouristate.edu)
  • The location and topography of the corresponding sites are similar, although the strength and amino acid requirements of different interactions depend on the exact sequence of the signal and the particular AP complex involved. (grantome.com)
  • Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
  • BMCC1 (zeige PRUNE2 ELISA Kits ) is an AP-2 (zeige GTF3A ELISA Kits ) associated endosomal protein in prostate cancer cells. (antikoerper-online.de)
  • Arkadia (zeige RNF111 ELISA Kits ) complexes with clathrin adaptor AP2 (zeige GTF3A ELISA Kits ) mu2 subunit and regulates EGF (zeige EGF ELISA Kits ) signalling. (antikoerper-online.de)
  • Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
  • Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (nih.gov)
  • Genes encoding subunits of the endomembrane trafficking system. (elifesciences.org)
  • All genes encoding for the proteins part of this complex have been associated with genetic forms of HSP (e.g. (biomedcentral.com)
  • The NCBI RefSeq Genes composite track shows human protein-coding and non-protein-coding genes taken from the NCBI RNA reference sequences collection (RefSeq). (ucsc.edu)
  • We also demonstrated the occurrence of multiple AP-1 complexes resulting from combinatorial assembly of various gamma (i.e., gamma1 and gamma2) and sigma1 (i.e., sigma1A, sigma1B and sigma1C) subunit isoforms encoded by different genes. (grantome.com)
  • 7. The expression vector according to claim 5, wherein the recombinant nucleic acid according to claim 1 further comprises a protein coding sequence that encodes a reporter protein or a therapeutic protein. (freepatentsonline.com)
  • The human immunodeficiency virus type 1 (HIV-1) encodes a class of proteins that lack any known enzymatic activity. (nature.com)
  • AP50 is a subunit of the plasma membrane adaptor. (xenbase.org)
  • Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells. (nih.gov)
  • It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). (genecards.org)
  • Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. (gen-script.com)
  • HSV and PRV gE/gI complexes are required for efficient spread of viruses between certain cultured epithelial cells, neurons, and other polarized cells with extensive cell junctions but are not needed for spread between highly transformed, nonpolarized cells, which do not form cell junctions ( 12 , 13 , 27 , 42 , 47 , 51 ). (asm.org)
  • Together, our data suggests that the AP-3 complex plays a critical role in the trafficking of HRSV proteins specifically matrix in epithelial cells. (missouristate.edu)
  • Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). (genecards.org)
  • Recombinant protein encompassing a sequence within the center region of human AP4M1. (genetex.com)
  • AP4M1 antibody [N1C1] detects AP4M1 protein at cytoplasm in mouse testis by immunohistochemical analysis. (genetex.com)
  • In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. (genecards.org)
  • Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. (uniprot.org)
  • Component of the adaptor complexes which link clathrin to receptors in coated vesicles. (xenbase.org)
  • The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. (antibodies-online.com)
  • This traffic is bidirectional, to ensure that proteins required to form vesicles are recycled. (embl.de)
  • Clathrin coats contain both clathrin and adaptor complexes that link clathrin to receptors in coated vesicles. (embl.de)
  • Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:14745134, PubMed:15473838). (icr.ac.uk)
  • To address these issues, we have utilized the powerful new approach of subcellular proteomics to identify novel proteins present on highly enriched clathrin-coated vesicles (CCVs). (rupress.org)
  • The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin 2 are evolutionarily conserved from worm to man, thereby identifying stonin 2 and its invertebrate homologs uncoordinated (UNC)-41 and stoned B as endocytic adaptors dedicated to the retrieval of surface-stranded SV proteins, most notably synaptotagmin. (nih.gov)
  • Contains 1 MHD (mu homology) domain. (abcam.com)
  • There are three classes of mammalian Arf proteins, distinguished by size and homology ( 1 ). (bioscience.org)
  • This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. (ucsc.edu)
  • Although no sequence homology has been reported with other known proteins, FLCN is highly conserved across species, being 92% identical to its mouse ortholog, 28% identical to its D. melanogaster ortholog and 22% to the C. elegans ortholog. (frontiersin.org)
  • This protein is capable of interacting with tyrosine-based sorting signals. (nih.gov)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Overview of all the structural information available in the PDB for UniProt: O00189 (Human AP-4 complex subunit mu-1) at the PDBe-KB. (wikipedia.org)
  • Defects in formation of the complex or in its ability to interact directly with cargo inhibit enzyme uptake and lead to defective cell walls and aberrant hyphal morphology. (asm.org)
  • Based on our work, we hypothesize that defects in these diseases are caused by abnormal sorting of specific cargo proteins having dileucine-based signals. (grantome.com)
  • Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole. (mybiosource.com)
  • Cargo sorting is essential for plant survival and therefore necessitates complex molecular machinery. (plantphysiol.org)
  • AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). (genecards.org)
  • The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. (icr.ac.uk)
  • The present invention provides a recombinant DNA that is composed of a promoter, a protein coding region, and the hybrid 3′UTR in a continuous and directional orientation. (freepatentsonline.com)
  • Antibody Reactive Against Recombinant Protein. (proteogenix-products.com)
  • In particular, owing to its high growth rate and its relatively well identified genetic structure compared to other organisms, the bacterium E. coli is routinely used as a host cell for production of target proteins using genetic recombinant techniques. (justia.com)
  • Because of recombinant proteins having low refolding rates, high-cost apparatuses are necessary for scaling up their industrial production, and most proteins having a high molecular weight are hard or impossible to refold, thereby creating difficulty in industrialization of such proteins. (justia.com)
  • Typically, refolding a protein into an active form is accomplished experimentally, and is not always successfully achieved, thereby making large-scale production of a recombinant protein difficult. (justia.com)
  • However, we are making a recombinant protein, with 2 tags, and in yeast cells. (promab.com)
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • The highly-conserved Notch signaling pathway is unique, as both the Notch receptor and most of its respective ligands (canonically the DSL or Delta/Serrate/lag-2 family members) are transmembrane proteins attached to the cell surface. (antibodies-online.com)
  • Proteins required for nutrient uptake or cell wall biosynthesis in the new environment are incorporated into the plasma membrane via the secretory pathway. (asm.org)
  • Using Rab5 mutants or depletion of the mu-subunit of AP-2 or clathrin heavy chain by RNA interference, we demonstrate that KIAA0319 follows a clathrin-mediated endocytic pathway. (ox.ac.uk)
  • Part of the AP-3 complex, an adaptor-related complex which is essential for the compartmentalization of the endocytic pathway. (mybiosource.com)
  • As determined by confocal microscopy, HCV proteins expressed from VT7-HCV7.9 localize largely in a globular-like distribution pattern in the cytoplasm, with some proteins co-localizing with the endoplasmic reticulum (ER) and mitochondria. (biomedcentral.com)
  • In addition, when a target protein is expressed in a large scale in E. coli , the expressed proteins frequently accumulate in the cytoplasm, forming insoluble protein aggregates referred to as inclusion bodies. (justia.com)
  • A component of the AP-1 clathrin adapter complexes, μ1B, that is involved in sorting of proteins to basolateral surfaces was involved in targeting of PRV particles to lateral surfaces. (asm.org)
  • As examined by electron microscopy, HCV proteins induced formation of large electron-dense cytoplasmic structures derived from the ER and containing HCV proteins. (biomedcentral.com)
  • 1999). The amyloid precursor protein (APP), implicated in Alzheimer's disease, contains such a signal in its cytoplasmic tail. (reactome.org)
  • Interestingly, Nef, AP-1 and MHC-I have been described to form a ternary complex which depends on the cytoplasmic tail of MHC-I 10 . (nature.com)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • 8. An isolated host cell comprising the expression vector of claim 5 wherein the expression vector of claim 5 comprises a protein coding sequence, and the host cell transiently or encoded in the expression vector of claim 5. (freepatentsonline.com)
  • 9. An isolated host cell which is obtained by in vivo injection of the expression vector of claim 5 into a cell, wherein the expression vector of claim 5 comprises a protein coding sequence, and the host cell comprises the expression vector of claim 5 and transiently or encoded in the expression vector of claim 5. (freepatentsonline.com)
  • MISCAST is an interactive and user-friendly web server to visualize and analyze missense variants in protein sequence and structure space. (uni.lu)
  • Analysis of point-mutated HRSV M derivatives indicated that AP-3Mu3A- mediated trafficking is contingent on the presence of the tyrosine residue within the YXXL sorting sequence at amino acids 197-200 of the M protein. (missouristate.edu)
  • Using the same cutoff, approximately 67% of the cDNAs have a BLAST hit in the NCBI non-redundant protein and nucleotide sequence databases (nr and nt), suggesting that one third of the sequences may be unique to L. stagnalis . (biomedcentral.com)
  • Biochemical and X-ray crystallographic analyses revealed that the properties of the APP sequence and the location of the binding site on mu4 are distinct from those of canonical tyrosine-based signals binding to the mu subunits of other AP complexes. (grantome.com)
  • The encoded protein belongs to the adaptor complexes medium subunits family. (genecards.org)
  • The present study has identified the medium subunit (mu2) of adaptor protein 2 (AP-2) as a binding partner of KIAA0319 in a yeast two-hybrid screen. (ox.ac.uk)
  • Unfortunately, the antiserum fails to recognize the native protein in whole-mount ovaries or embryos (Liu, 1999). (sdbonline.org)
  • In this model, we observed that HCV proteins control cellular translation through eIF-2α-S51 phosphorylation, with involvement of the double-stranded RNA-dependent protein kinase PKR. (biomedcentral.com)
  • These changes may be a direct result of viral proteins targeting cellular machinery, or an indirect effect associated with viral replication. (bioscience.org)
  • mutations affecting this protein thus lead to different phenotypes depending on the cellular context. (frontiersin.org)
  • In particular, septin-associated protein kinases couple cell cycle progression with cellular morphogenesis. (frontiersin.org)
  • They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). (genecards.org)
  • Among its related pathways are Chaperonin-mediated protein folding and Metabolism of proteins . (genecards.org)
  • ADP ribosylation factors (Arfs) constitute a family of GTP binding proteins that regulate membrane trafficking pathways. (bioscience.org)
  • In particular, as discussed here, septin-based structures recruit, and thereby localize (and, in some cases, regulate the activity of) a multiplicity of protein kinases that integrate multiple inputs into signaling pathways and ultimately initiate ensuing biological responses (Figure 1 ). (frontiersin.org)