A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.
An adaptor protein complex found primarily on perinuclear compartments.
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.
An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.
The subunits that make up the large, medium and small chains of adaptor proteins.
A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.
A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.
A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.
The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)
A subclass of clathrin assembly proteins that occur as monomers.
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL SURFACE RECEPTORS to MITOGEN-ACTIVATED PROTEIN KINASES.
A family of small adaptin protein complex subunits of approximately 19 KDa in size.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Phosphorylation of the medium chain subunit of the AP-2 adaptor complex does not influence its interaction with the tyrosine based internalisation motif of TGN38. (1/92)

Tyrosine based motifs conforming to the consensus YXXphi (where phi represents a bulky hydrophobic residue) have been shown to interact with the medium chain subunit of clathrin adaptor complexes. These medium chains are targets for phosphorylation by a kinase activity associated with clathrin coated vesicles. We have used the clathrin coated vesicle associated kinase activity to specifically phosphorylate a soluble recombinant fusion protein of mu2, the medium chain subunit of the plasma membrane associated adaptor protein complex AP-2. We have tested whether this phosphorylation has any effect on the interaction of mu2 with the tyrosine based motif containing protein, TGN38, that has previously been shown to interact with mu2. Phosphorylation of mu2 was shown to have no significant effect on the in vitro interaction of mu2 with the cytosolic domain of TGN38, indicating that reversible phosphorylation of mu2 does not play a role in regulating its direct interaction with tyrosine based internalisation motifs. In addition, although a casein kinase II-like activity has been shown to be associated with clathrin coated vesicles, we show that mu2 is not phosphorylated by casein kinase II implying that another kinase activity is present in clathrin coated vesicles. Furthermore the kinase activity associated with clathrin coated vesicles was shown to be capable of phosphorylating dynamin 1. Phosphorylation of dynamin 1 has previously been shown to regulate its interaction with other proteins involved in clathrin mediated endocytosis.  (+info)

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. (2/92)

Although interactions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based internalization motifs have been implicated in the selective recruitment of cargo molecules into coated pits, the functional significance of this interaction for endocytosis of many types of membrane proteins remains unclear. To analyze the function of mu2-receptor interactions, we constructed an epitope-tagged mu2 that incorporates into AP-2 and is targeted to coated pits. Mutational analysis revealed that Asp176 and Trp421 of mu2 are involved in the interaction with internalization motifs of TGN38 and epidermal growth factor (EGF) receptor. Inducible overexpression of mutant mu2, in which these two residues were changed to alanines, resulted in metabolic replacement of endogenous mu2 in AP-2 complexes and complete abrogation of AP-2 interaction with the tyrosine-based internalization motifs. As a consequence, endocytosis of the transferrin receptor was severely impaired. In contrast, internalization of the EGF receptor was not affected. These results demonstrate the potential usefulness of the dominant-interfering approach for functional analysis of the adaptor protein family, and indicate that clathrin-mediated endocytosis may proceed in both a mu2-dependent and -independent manner.  (+info)

Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. (3/92)

The apical and basolateral plasma membrane domains of polarized epithelial cells contain distinct sets of integral membrane proteins. Biosynthetic targeting of proteins to the basolateral plasma membrane is mediated by cytosolic tail determinants, many of which resemble signals involved in the rapid endocytosis or lysosomal targeting. Since these signals are recognized by adaptor proteins, we hypothesized that there could be epithelial-specific adaptors involved in polarized sorting. Here, we report the identification of a novel member of the adaptor medium chain family, named mu1B, which is closely related to the previously described mu1A (79% amino acid sequence identity). Northern blotting and in situ hybridization analyses reveal the specific expression of mu1B mRNA in a subset of polarized epithelial and exocrine cells. Yeast two-hybrid analyses show that mu1B is capable of interacting with generic tyrosine-based sorting signals. These observations suggest that mu1B may be involved in protein sorting events specific to polarized cells.  (+info)

A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. (4/92)

Although polarized epithelial cells are well known to maintain distinct apical and basolateral plasma membrane domains, the mechanisms responsible for targeting membrane proteins to the apical or basolateral surfaces have remained elusive. We have identified a novel form of the AP-1 clathrin adaptor complex that contains as one of its subunits mu1B, an epithelial cell-specific homolog of the ubiquitously expressed mu1A. LLC-PK1 kidney epithelial cells do not express mu1B and missort many basolateral proteins to the apical surface. Stable expression of mu1B selectively restored basolateral targeting, improved the overall organization of LLC-PK1 monolayers, and had no effect on apical targeting. We conclude that basolateral sorting is mediated by an epithelial cell-specific version of the AP-1 complex containing mu1B.  (+info)

mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. (5/92)

The heterotetrameric AP-1 complex is involved in the formation of clathrin-coated vesicles at the trans-Golgi network (TGN) and interacts with sorting signals in the cytoplasmic tails of cargo molecules. Targeted disruption of the mouse mu1A-adaptin gene causes embryonic lethality at day 13.5. In cells deficient in micro1A-adaptin the remaining AP-1 adaptins do not bind to the TGN. Polarized epithelial cells are the only cells of micro1A-adaptin-deficient embryos that show gamma-adaptin binding to membranes, indicating the formation of an epithelial specific AP-1B complex and demonstrating the absence of additional mu1A homologs. Mannose 6-phosphate receptors are cargo molecules that exit the TGN via AP-1-clathrin-coated vesicles. The steady-state distribution of the mannose 6-phosphate receptors MPR46 and MPR300 in mu1A-deficient cells is shifted to endosomes at the expense of the TGN. MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor.  (+info)

Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. (6/92)

HIV-1 Nef interacts with cellular adaptor protein (AP) complexes and their medium (mu) subunits. However, the role of the dileucine-based sorting motif within Nef in these interactions has been incompletely characterized. Here, yeast two-hybrid assays indicated that HIV-1 Nef interacted not only with the mu subunits of AP-1 and AP-2, but also with that of AP-3. The interactions with mu1 and mu3 were markedly stronger than the interaction with mu2. Leucine residues of the sorting motif were required for the interactions with mu3 and mu2 and contributed to the interaction with mu1. Confocal immunofluorescence microscopy indicated that Nef, AP-1, and AP-3 (but not AP-2) were concentrated in a juxtanuclear region near the cell center, potentially facilitating interaction between Nef and the mu1 and mu3 subunits. However, leucine residues of the sorting motif were not required for this subcellular localization of Nef. These data suggest that the dileucine motif, required for optimal viral replication, functions through interactions with a variety of AP complexes, including AP-3, potentially by recruiting adaptor complexes to subcellular locations specified by additional determinants in the Nef protein.  (+info)

RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. (7/92)

RLIP76 is a modular protein that was identified as a putative effector of Ral, a GTPase activated during Ras signaling. To explore further the contribution of the Ral-RLIP76 pathway to Ras signaling, we have looked for partners of RLIP76. Mu2, the medium chain of the AP2 complex is shown to interact with RLIP76. We show also that in vivo endogenous AP2 and RLIP76 form a complex and that this in vivo interaction is independent of cells being stimulated by a growth factor. Furthermore, RLIP76 differentiates AP2 from AP1 in vivo as RLIP76 differentiates mu2 from mu1 in vitro and in two hybrid assays. We show that activated Ral interferes with both tranferrin receptor endocytosis and epidermal growth factor (EGF) receptor endocytosis in HeLa cells. We propose a model where the Ral-RLIP76 pathway connects signal transduction and endocytosis through interaction on one hand between the Ras-Ral pathway and RLIP, on the other hand between RLIP and proteins belonging to the endocytotic machinery.  (+info)

Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. (8/92)

In the nematode Caenorhabditis elegans, there exist two micro1 medium chains of the AP-1 clathrin-associated protein complex. Mutations of unc-101, the gene that encodes one of the micro1 chains, cause pleiotropic effects (). In this report, we identified and analyzed the second mu1 chain gene, apm-1. Unlike the mammalian homologs, the two medium chains are expressed ubiquitously throughout development. RNA interference (RNAi) experiments with apm-1 showed that apm-1 and unc-101 were redundant in embryogenesis and in vulval development. Consistent with this, a hybrid protein containing APM-1, when overexpressed, rescued the phenotype of an unc-101 mutant. However, single disruptions of apm-1 or unc-101 have distinct phenotypes, indicating that the two medium chains may have distinct functions. RNAi of any one of the small or large chains of AP-1 complex (sigma1, beta1, or gamma) showed a phenotype identical to that caused by the simultaneous disruption of unc-101 and apm-1, but not that by single disruption of either gene. This suggests that the two medium chains may share large and small chains in the AP-1 complexes. Thus, apm-1 and unc-101 encode two highly related micro1 chains that share redundant and distinct functions within AP-1 clathrin-associated protein complexes of the same tissue.  (+info)

antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals.
antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals.
The function of the different organelles that comprise the secretory and endocytic pathways in eukaryotic cells is determined by the complement of resident proteins present within the respective organelle. The mechanisms that govern membrane protein localisation to the different organelles rely on intrinsic information in the membrane protein such as sorting motifs in the cytoplasmic domain and extrinsic factors such as coat-proteins that recognise the sorting motifs.. A well-studied example of these concepts is the sorting of membrane proteins by the clathrin-coated vesicle (CCV) adaptor proteins through recognition of the YXXΦ sorting motif. This tetra-peptide motif, comprising Tyr-X-X (where X is any amino acid)-bulky hydrophobic, is bound by the medium chain (μ) subunit of adaptor complexes resulting in the protein containing the YXXΦ motif being concentrated in CCVs (Ohno et al., 1995; Owen and Evans, 1998) (reviewed in Bonifacino and Traub, 2003). Another example of sorting motifs ...
From NCBI Gene:. The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]. From UniProt: ...
AP1S3_HUMAN] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904).[1] [AP1G1_MOUSE] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [BST2_HUMAN] IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell ...
Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves …
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced relatively low rates of gene gain and loss in multigene families. To investigate this possibility and to explore the phenotypic consequences of variation in gene copy number, we examined evolutionary changes in the families of genes that encode the α- and β-type subunits of hemoglobin (Hb), the tetrameric α2β2 protein responsible for blood-O2 transport. A comparative genomic analysis of 52 bird species revealed that the size and membership composition of the α- and β-globin gene families have remained remarkably constant during approximately 100 My of avian evolution. Most interspecific variation in gene content is attributable to multiple independent inactivations of the αD-globin gene, which encodes the α-chain subunit of a functionally distinct Hb isoform (HbD) that is expressed in both embryonic and definitive erythrocytes. Due to consistent differences in O2-binding properties between HbD and
The AP-complex family (Boehm and Bonifacino, 2001; Nakatsu and Ohno, 2003; Owen et al., 2004; Robinson, 2004) has six members in mammals. AP-1A, AP-2, AP-3A and AP-4 are ubiquitously expressed. The other two members, AP-5 and AP-6, are cell-type-specific isoforms of AP-1A and AP-3A: the epithelium-specific AP-1B and the neuron-restricted AP-3B.. The AP complexes consist of four subunits: one small (σ1-σ4), one medium (μ1-μ4) and two large (α, γ, δ or ϵ; and β1-β4) subunits. These assemble to form a structure in which two appendage domains are connected by flexible hinge regions to the core (Owen et al., 2004; Owen and Luzio, 2000; Robinson, 2004). The large subunits are divided into three domains: the N-terminal domain, which makes up the core with the μ and σ subunits; the hinge domain, and the C-terminal appendage. One of the large subunits (α, γ, δ or ϵ) is implicated in binding to the target membrane (Collins et al., 2002; Nakatsu and Ohno, 2003; Owen et al., 2004; Traub, ...
The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the…
ARF6 was shown early on to localize to invadopodia, specialized matrix degradative structures of tumor cells, and to be required for invadopodial activity (Hashimoto et al., 2004; Tague et al., 2004). Pioneering work identified an ARF6 pathway in which ARF6 activated by the guanine nucleotide exchange factor GEP100 at the plasma membrane is pivotal for invasion and metastasis of breast tumor-derived cell lines (Onodera et al., 2005, 2012; Hashimoto et al., 2006; Morishige et al., 2008). Here, we found that ARF6, MT1-MMP, and KIF5B kinesin-1 heavy chain subunit are abnormally overexpressed in high-grade TNBCs. To our knowledge, this is the first study reporting on dysregulation of ARF6 protein levels and its correlation with MT1-MMP in breast tumor specimens. Up-regulation of ARF6, MT1-MMP, and KIF5B in TNBCs is pathologically highly relevant given the correlation between MT1-MMP levels and tumor progression and increased metastatic potential in this subgroup of highly aggressive breast cancers ...
When released from the 20°C block, VSVG emigrated away from membranes positive for conventional Golgi to closely apposed structures that were positive for AP-1B and Exo70. Intriguingly, Exo70 also strongly localized to Tfn- and TfnR-positive recycling endosomes. Thus, it seems possible that AP-1B-dependent cargo may at least partially enter recycling endosomes before continuing to the plasma membrane after exit from the Golgi. Our data are thus in agreement with previous observations showing that Rab11 (a recycling endosome-associated GTPase) may play a role in biosynthetic traffic, at least in nonpolarized cells (Chen et al., 1998). Moreover, both the TGN and recycling endosomes are complex sorting compartments (Mellman and Warren, 2000). In the case of epithelial cells, it is also interesting to note that polarized targeting of newly synthesized and recycling glycoproteins makes use of similar or identical sorting determinants in the TGN and in the endocytic pathway (Matter et al., 1993; ...
Synonyms: cytochrome b558 subunit beta (human) superoxide-generating NADPH oxidase heavy chain subunit (human) neutrophil cytochrome b 91 kDa polypeptide (human) cytochrome b(558) subunit beta (human) gp91-1 (human) gp91-phox (human) hCYBB NADPH oxidase 2 (human) heme-binding membrane glycoprotein gp91phox (human) CGD91-phox (human) ...
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Katya Heldwein, PhD, Principal Investigator. Katya received her PhD from Oregon Health Sciences University in Portland, OR where she studied ligand recognition by bacterial transcription regulators using x-ray crystallography in the laboratory of Richard Brennan. She then did her postdoctoral work at Harvard Medical School in the laboratory of Stephen Harrison where she initially worked on clathrin adaptor complexes and later delved into herpesvirus cell entry. She opened her own laboratory at Tufts University School of Medicine in the Fall of 2006.. ...
In the present work, we have investigated mechanisms involved in the nucleotide-dependent regulation of clathrin-coated pit nucleation at the synapse. Our results implicate ARF6 in this process and demonstrate two effects of the GTP-bound form of this small GTPase; stimulation of the recruitment of clathrin/AP-2 to presynaptic membranes and binding plus activation of PIPKIγ. They also suggest that the two effects are related and that PI(4,5)P2 production by PIPKIγ stimulation represents the major mechanism through which ARF6 enhances clathrin/AP-2 recruitment. The action of GTP-ARF6 on clathrin/AP-2 recruitment mimics the effect of GTPγs, and its effects are antagonized by experimental manipulations that prevent either ARF activation (i.e., dominant-negative ARF6) or PI(4,5)P2 production and availability (i.e., kinase inhibition, PIPKIγ depletion, and PI(4,5)P2 hydrolysis by synaptojanins inositol 5′-phosphatase domain). These results strongly indicate that enhanced clathrin coat ...
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids. [-] ...
Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a Novartis product and was approved by the Food and Drug Administration (FDA) in 1998. Basiliximab is an immunosuppressant agent used to prevent immediate transplant rejection in people who are receiving kidney transplants, in combination with other agents. It has been reported that some cases of lichen planus have been successfully treated with basiliximab as an alternative therapy to ciclosporin. No short-term side effects have been reported. Basiliximab competes with IL-2 to bind to the alpha chain subunit of the IL2 receptor on the surface of the activated T lymphocytes and thus prevents the receptor from signaling. This prevents T cells from replicating and also from activating B cells, which are responsible for the production of antibodies, which would bind to ...
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Function: Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis (By similarity ...
The journal focuses on neuroimmunology and neuroinflammation, and the coverage extends to other basic and clinical studies related to neuroscience including molecular biology, psychology, pathology, physiology, endocrinology, pharmacology, oncology, etc.
பகல் பன்னிரண்டு மணிக்கு மீண்டும் திருச்சூரை நோக்கிப் புறப்பட்டோம். திருச்சூரைக் கடந்து குன்னங்குளம் என்ற ஊரை நோக்கி எங்கள் மகிழ்வுந்து பறந்தது. நல்ல சாலை அமைப்பு என்பதால் திட்டமிட்டதை விட வேகமாக நாங்கள் திருச்சூரைக் கடந்தோம். வழியில் அண்ணன் வீரக்குமரன் அவர்களின் விரிவுரை மகிழ்வுந்தில் அமைந்தது. முனைவர் வீரக்குமரன் அவர்கள் தமிழ், ஆங்கிலம், மலையாளம் என ...
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Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). ...
Medium Chain Triglycerides might be a saturated fat, but that doesnt mean theyre bad for you. In fact, far from it, says Peter Wilson. Fat is bad for you right? The supermarkets are all selling low fat products and we are all told how we should be reducing our cholesterol. The media has used a really broad brush here
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
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Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a ... mu), and a small adaptin (sigma): complex 1 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 complex 2 AP2A1 AP2A2 AP2B1 AP2M1 ... 2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. PMC 3191125. PMID ... Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular ...
... endosomal and the secretory pathways of integral membrane proteins by interacting with the mu subunits of the adaptor protein ( ... AP) complex. The signal-transducing adaptor protein 1 (STAP1) Src homology 2 (SH2) domain binding motif at Tyr446 - Ile450 ( ... S-palmitoylation can also modulate protein-protein interactions of SLC46A3 by changing the affinity of the protein for lipid ... NF-Y is a heterotrimeric complex of three different subunits (NF-YA, NF-YB, NF-YC) that regulates gene expression, both ...
... mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 corresponding to the 5 AP complexes. Components of COPI ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ... but not closely related to the AP/TSET complexes. The individual proteins of the COPII complex are called SEC proteins, because ...
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. The heterotetrameric adaptor protein (AP ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma ... "Entrez Gene: adaptor-related protein complex 4". CS1 maint: discouraged parameter (link) Abou Jamra R, Philippe O, Raas- ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (AP4M1), and a small ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... "Entrez Gene: adaptor-related protein complex 4". Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck ...
... cytosolic adaptor proteins (such as MyD88 adaptor protein) and insect and nematode Toll. Each of these groups is involved ... TIR domain present on receptor creates a heterodimer with TIR domain on accessory protein. This high affinity receptor complex ... Martin MU, Wesche H (November 2002). "Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor ... IL-1RAcP is a second receptor subunit of IL-1RI. By forming a receptor heterodimer with IL-1RI facilitates signalization due to ...
... adaptor protein complex gamma subunits MeSH D12.776.543.990.150.500.500 - adaptor protein complex mu subunits MeSH D12.776. ... adaptor protein complex alpha subunits MeSH D12.776.543.990.150.500.200 - adaptor protein complex beta subunits MeSH D12.776. ... adaptor protein complex 4 MeSH D12.776.543.990.150.500 - adaptor protein complex subunits MeSH D12.776.543.990.150.500.100 - ... adaptor protein complex 1 MeSH D12.776.543.990.150.200 - adaptor protein complex 2 MeSH D12.776.543.990.150.300 - adaptor ...
As part of a heterodimer, importin-β mediates interactions with the pore complex, while importin-α acts as an adaptor protein ... Kim IS, Kim DH, Han SM, Chin MU, Nam HJ, Cho HP, Choi SY, Song BJ, Kim ER, Bae YS, Moon YH (July 2000). "Truncated form of ... Görlich D, Kostka S, Kraft R, Dingwall C, Laskey RA, Hartmann E, Prehn S (April 1995). "Two different subunits of importin ... but the key proteins involved had not been elucidated up until that point. A 60 kDa cytosolic protein, essential for protein ...
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... Chauhan AK, Moore TL (2012). "Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human ... Chauhan AK, Moore TL (2011). "T cell activation by terminal complex of complement and immune complexes". The Journal of ...
Ionizable residues in the transmembrane domain of each subunit form a polar network of interactions that hold the complex ... to bind to the ITAM and activated ZAP-70 phosphorylates tyrosines on the adaptor protein LAT, which then attracts PLC-γ. Other ... The TCR complex[edit]. The TCR receptor complex is an octomeric complex of variable TCR receptor α and β chains with three ... Associated molecules of the TCR complex involved in T-cell activation[edit]. The essential function of the TCR complex is to ...
Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many ... G-protein coupled receptor signaling pathway. • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway. • G- ... clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2 unable to mobilize ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...
Signal transducing adaptor protein. *Scaffold protein. Transcription factors. *General. *Transcription preinitiation complex ... They have a heteromeric structure in that each subunit consists of the extracellular ligand-binding domain and a transmembrane ... and can be a protein or peptide (short protein), or another small molecule such as a neurotransmitter, hormone, pharmaceutical ... In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.[1] When ...
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... Chauhan, A. K., and Moore, T. L. (2012) Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... Chauhan, A. K., and Moore, T. L. (2011) T cell activation by terminal complex of complement and immune complexes. The Journal ...
adapter-related protein complex 5 mu subunit. adapter-related protein complex 5 subunit mu-1. adaptor related protein complex 5 ... AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo sapiens] AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo ... AP-5 complex subunit mu-1. Names. AP-5 complex subunit mu. MHD domain-containing death-inducing protein. MU-2/AP1M2 domain ... adaptor related protein complex 5 subunit mu 1provided by HGNC. Primary source. HGNC:HGNC:20192 See related. Ensembl: ...
adaptor protein complex AP-1 mu-2 subunit. adaptor related protein complex 1 mu 2 subunit. clathrin assembly protein complex 1 ... AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens] AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo ... clathrin-associated adaptor medium chain mu2. golgi adaptor AP-1 47 kDa protein. golgi adaptor HA1/AP1 adaptin mu-2 subunit. mu ... General protein information Go to the top of the page Help Preferred Names. AP-1 complex subunit mu-2. Names. AP-mu chain ...
Compare adaptor related protein complex 3 subunit mu 1 ELISA Kits from leading suppliers on Biocompare. View specifications, ... adaptor related protein complex 3 subunit mu 1 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used ... Your search returned 14 adaptor related protein complex 3 subunit mu 1 ELISA ELISA Kit across 2 suppliers. ... Watch Webinar: How To Get Speed and Depth in your Host Cell Protein (HCP) Analysis ...
... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... anti-Adaptor-Related Protein Complex 1, mu 2 Subunit Antibodies * anti-Adaptor-Related Protein Complex 1, mu 1 Subunit ... anti-Adaptor-Related Protein Complex 3, mu 1 Subunit Antibodies * anti-Adaptor-Related Protein Complex 3, mu 2 Subunit ... anti-Adaptor-Related Protein Complex 4, mu 1 Subunit Antibodies * anti-Adaptor-Related Protein Complex 5, mu 1 Subunit ...
... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... AP-2 complex subunit mu-1-A , AP-2 complex subunit mu-A , AP-2 mu-2 chain A , AP-2 mu-A chain , adaptor protein complex AP-2, ... adaptor related protein complex 2 mu 1 subunit (AP2M1) Elisa Kit * adaptor-related protein complex 2, mu 1 subunit, a (ap2m1a) ... adaptor-related protein complex 2, mu 1 subunit (Ap2m1) Elisa Kit * adaptor related protein complex 2 mu 1 subunit L homeolog ( ...
Adaptor protein complex AP-2 subunit mu explanation free. What is Adaptor protein complex AP-2 subunit mu? Meaning of Adaptor ... protein complex AP-2 subunit mu medical term. What does Adaptor protein complex AP-2 subunit mu mean? ... Looking for online definition of Adaptor protein complex AP-2 subunit mu in the Medical Dictionary? ... Adaptor protein complex AP-2 subunit mu , definition of Adaptor protein complex AP-2 subunit mu by Medical dictionary https:// ...
... mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP) ... AP-4 complex subunit mu-1. A. 301. Homo sapiens. Mutation(s): 2 Gene Names: AP4M1 (MUARP2). ... Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the ... Sorting of the Alzheimers disease amyloid precursor protein mediated by the AP-4 complex.. Burgos, P.V., Mardones, G.A., Rojas ...
Protein Coding), Adaptor Related Protein Complex 4 Mu 1 Subunit, including: function, proteins, disorders, pathways, orthologs ... AP4M1 (Adaptor Related Protein Complex 4 Mu 1 Subunit) is a Protein Coding gene. Diseases associated with AP4M1 include Spastic ... AP4M1 Gene(Protein Coding) Adaptor Related Protein Complex 4 Mu 1 Subunit. ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ...
Protein Coding), Adaptor Related Protein Complex 3 Mu 1 Subunit, including: function, proteins, disorders, pathways, orthologs ... AP3M1 (Adaptor Related Protein Complex 3 Mu 1 Subunit) is a Protein Coding gene. Among its related pathways are Chaperonin- ... AP3M1 Gene(Protein Coding) Adaptor Related Protein Complex 3 Mu 1 Subunit. ... Protein Symbol:. Q9Y2T2-AP3M1_HUMAN. Recommended name:. AP-3 complex subunit mu-1 Protein Accession:. Q9Y2T2. Secondary ...
Adaptor Protein Complex mu Subunits / metabolism * Arabidopsis / genetics* * Arabidopsis / metabolism* * Brefeldin A / ... Co-immunoprecipitation experiments show that hTfR is able to interact with a mu-adaptin subunit from Arabidopsis cytosol, a ... inhibits the interaction between the YTRF endocytosis signal in the hTfR cytosolic tail and the mu2-subunit of the AP2 complex ...
... of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in ... Adaptor Protein Complex mu Subunits / chemistry * Adaptor Protein Complex mu Subunits / metabolism ... Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo- ... protein synaptotagmin 1. The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin ...
Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor ... The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting ... Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and ... but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Tyr-156 in membrane- ...
... adaptor protein complex AP-1 mu-1 subunit , adaptor-related protein complex 1 mu-1 subunit , clathrin adaptor protein AP47 , ... anti-Adaptor-Related Protein Complex 3, mu 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 3, mu 2 Subunit ... anti-Adaptor-Related Protein Complex 4, mu 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 5, mu 1 Subunit ... adaptor-related protein complex 1, mu 1 subunit (Ap1m1) Antikörper * adaptor-related protein complex AP-1, mu subunit 1 (Ap1m1 ...
adaptor-related protein complex 2, mu 1 subunit [Source:HGNC Symbol;Acc:564]. Mouse Orthologue:. Ap2m1. Mouse Description:. ... AP-2 complex subunit mu-1-A [Source:UniProtKB/Swiss-Prot;Acc:Q6NWK2]. Human Orthologue:. AP2M1. Human Description:. ... adaptor protein complex AP-2, mu1 Gene [Source:MGI Symbol;Acc:MGI:1298405]. ...
adaptor-related protein complex 3, mu 2 subunit. MGI:1929214 1 matching records from 1 references.. Summary by Age and Assay: ... Ap3m2 adaptor-related protein complex 3, mu 2 subunit (Synonyms: 5830445E16Rik, AP-3B) ...
adaptor-related protein complex 3, mu 1 subunit. 6169822. Full Length. BC067127. adaptor-related protein complex 3, mu 1 ... BP] protein targeting to lysosome *[CC] Golgi apparatus *[CC] clathrin adaptor complex *[CC] lysosome *[MF] protein binding ... Protein Similarities Based on Shared Motif Content. Find gene products sharing protein motifs with: NP_036227 NP_996895 Protein ... AP3M1, adaptor-related protein complex 3, mu 1 subunit. Sequence ID:. NM_012095. NM_207012. ...
The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... Adaptor related protein complex 1 mu 1 subunit. Protein classi. Protein class the gene product belongs to according to selected ... AP-1 complex subunit mu-1 A0A024R7K8 [Target identity:100%; Query identity:100%]. Adaptor-related protein complex 1, mu 1 ... Adaptor related protein complex 1 mu 1 subunit (HGNC Symbol). Entrez gene summary. The protein encoded by this gene is the ...
adaptor-related protein complex AP-1, mu subunit 1. MGI:102776 Go Annotations as Summary Text (Tabular View) (GO Graph). ... adaptor related protein complex 1 subunit mu 1).. Go Annotations in Tabular Form (Text View) (GO Graph) Filter annotations by: ...
Adapter-related protein complex 3 mu-1 subunit antibody. *AP-3 adapter complex mu3A subunit antibody ... Belongs to the adaptor complexes medium subunit family.. Contains 1 MHD (mu homology) domain. ... Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi ... The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/ ...
adaptor related protein complex 3 mu 2 subunit. Alias. entrezgene 549404 entrezgene 549404 ...
Adaptor-related protein complex 2, mu 1 subunit. NM_004068. NM_001025205. Gene Info. ... Adaptor-related protein complex 2, alpha 2 subunit. NM_001242837. NM_012305. Gene Info. ... ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9). NM_005175. NM_001002027. Gene Info. ... ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9). NM_001002031. NM_005176. Gene Info. ...
adaptor-related protein complex 2, mu 1 subunit. *AP-2 mu chain ... Plasma membrane adaptor AP-2 50 kDa protein. *plasma membrane ... Recombinant protein fragment corresponding to amino acids 97-383 of human AP2M1 (NP_001020376) produced in E.coli. ... Clathrin assembly protein complex 2 medium chain. *clathrin coat adaptor protein AP50 ... Clathrin coat assembly protein AP50. *Clathrin coat-associated protein AP50. *clathrin-associated/assembly/adaptor protein, ...
Major histocompatibility complex, class I, C. HLA-C. 434. 2278. NM_004068. Adaptor-related protein complex 2, mu 1 subunit. ... Coatomer protein complex, subunit epsilon. COPE. 263. 1179. NM_001861. Cytochrome c oxidase subunit IV isoform 1. COX4I1. 129. ... Preferred therapeutic proteins are interferones, growth factors, anti-angiogenesis proteins, apoptosis modulating proteins, ... activation protein, beta polypeptide. NM_003753. Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67 kDa. EIF3S7 ...
Adaptor-related protein complex 2, mu 1 subunit Assay Type: SYBR® Green Assay Design: Exonic Application: Gene Expression ... Adaptor-related protein complex 2, mu 1 subunit Assay Type: Probe Assay Design: Exonic Application: Gene Expression Unique ... The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease ...
adaptor-related protein complex 4, mu 1 subunit. Aliases:. CPSQ3, MU-4, MU-ARP2. ... The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition ... This gene encodes a subunit of the heterotetrameric AP-4 complex. ... and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [ ...
adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.169770. 7.812. 2 Whole brain. AD-cases-controls. GSE5281 Human Brain ... adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.346075. 13.696. 1 Whole brain. AD-cases-controls. GSE5281 Human ... adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.169697. 10.808. 3 Whole brain. AD-cases-controls-Myers. GSE15222 ... adaptor-related protein complex 1, mu 1 subunit; 3 UTR. Chr19: 16.207086. -0.780. ...
Gene Name: adaptor related protein complex 2 mu 1 subunit Synonyms: clapm1 Add Xenopus synonyms , Nomenclature history Gene ... NM_001087334,Xenopus laevis adaptor related protein complex 2 mu 1 subunit L homeolog (ap2m1.L), mRNA ... NM_203644,Xenopus tropicalis adaptor related protein complex 2 mu 1 subunit (ap2m1), mRNA ... Protein Refseq ,NP_988975,AP-2 complex subunit mu [Xenopus tropicalis] ...
Adaptins are clustered subunits of adaptor protein (AP) complexes. There are several types of adaptin, each related to a ... mu), and a small adaptin (sigma): complex 1 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 complex 2 AP2A1 AP2A2 AP2B1 AP2M1 ... 2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. PMC 3191125. PMID ... Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular ...
... mu 1 subunit) for IHC-P, WB. Anti-AP4M1 pAb (GTX115196) is tested in Human, Mouse samples. 100% Ab-Assurance. ... adaptor-related protein complex AP-4 mu4 subunit antibody, mu subunit of AP-4 antibody, AP-4 complex subunit mu-1 antibody, mu- ... adapter-related protein complex 4 mu-1 subunit antibody, mu4-adaptin antibody, "adaptor-related protein complex 4, mu 1 subunit ... adaptor-related protein complex 4, mu 1 subunit. Background. This gene encodes a subunit of the heterotetrameric AP-4 complex. ...
... adaptor related protein complex 1 mu 2 subunit) for IHC-P, WB. Anti-AP1M2 pAb (GTX33012) is tested in Human, Mouse samples. 100 ... adaptor related protein complex 1 mu 2 subunit. Background. This gene encodes a subunit of the heterotetrameric adaptor-related ... protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting ... Recombinant funsion protein containing a sequence corresponding to amino acids 164-423 of human AP1M2 (NP_005489.2).. ...
  • We identify dynamin and the EAP -binding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in clathrin mediated endocytosis. (antikoerper-online.de)
  • Co-immunoprecipitation experiments show that hTfR is able to interact with a mu-adaptin subunit from Arabidopsis cytosol, a process that is blocked by tyrphostin A23. (nih.gov)
  • There are several types of adaptin, each related to a different AP complex. (wikipedia.org)
  • This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. (antibodies-online.com)
  • The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). (antibodies-online.com)
  • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1 ), a medium adaptin (mu-type subunit AP1M1 or AP1M2 ) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3 ). (rcsb.org)
  • AP1M1, also named as CLTNM, Mu-adaptin 1 and Clathrin coat assembly protein AP47, belongs to the adaptor complexes medium subunit family. (ptglab.com)
  • This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. (thermofisher.com)
  • Beta adaptin is a subunit of the plasma membrane CC adaptor (By similarity). (univ-lyon1.fr)
  • SUBUNIT: Adaptor protein complex 2 (AP-2) is a heterotetramer CC composed of two large adaptins (alpha-type subunit apl3 and beta- CC type subunit apl1), a medium chain (mu-type subunit apm4) and a CC small adaptin (sigma-type subunit aps2). (univ-lyon1.fr)
  • Adaptin subunits recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal appendage domains. (embl.de)
  • By contrast, GGAs are monomers composed of four domains, which have functions similar to AP subunits: an N-terminal VHS (Vps27p/Hrs/Stam) domain, a GAT (GGA and Tom1) domain, a hinge region, and a C-terminal GAE (gamma-adaptin ear) domain. (embl.de)
  • Also known as AP-3 complex subunit beta (Adaptor protein complex AP-3 beta subunit) (Adaptor-related protein complex 3 subunit beta) (Beta-3-adaptin) (Clathrin assembly protein complex 3 beta large chain). (mybiosource.com)
  • Also known as AP-3 complex subunit delta (Adaptor-related protein complex 3 subunit delta) (Delta-adaptin 3) (Delta-adaptin). (mybiosource.com)
  • Also known as AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (BLVPCP1) (Bovine leukemia virus cell receptor) (BLV-R) (Delta-adaptin). (mybiosource.com)
  • Also known as AP-3 complex subunit mu (Adaptor protein complex AP-3 subunit mu) (Adaptor protein-3 mu-adaptin) (Adaptor-related protein complex 3 subunit mu) (At-muD-Ad) (Mu3-adaptin) (Protein ZIG SUPPRESSOR 4). (mybiosource.com)
  • We report here that HAPLESS13 (HAP13), the Arabidopsis µ1 adaptin, is essential for protein sorting at the TGN / EE . (plantphysiol.org)
  • Also known as AP-2 complex subunit alpha (Alpha-adaptin). (mybiosource.com)
  • Also known as AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit). (mybiosource.com)
  • Also known as AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit). (mybiosource.com)
  • Cell surface expression of hTfR increases upon treatment with tyrphostin A23, which inhibits the interaction between the YTRF endocytosis signal in the hTfR cytosolic tail and the mu2-subunit of the AP2 complex. (nih.gov)
  • Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. (nih.gov)
  • AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. (uniprot.org)
  • AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. (uniprot.org)
  • Accessory protein recruitment motifs in clathrin-mediated endocytosis. (eu.org)
  • AP2M1 is one of the most important cytoplasmic carrier domains in clathrin-mediated endocytosis, and phosphorylation of this subunit stimulates clathrin and supports cell surface receptor incorporation. (biomedcentral.com)
  • As a generalization, class I and II Arfs mainly localize to the trans-Golgi network (TGN), endoplasmic reticulum-Golgi intermediate complex (ERGIC) and Golgi apparatus to mediate membrane trafficking between these compartments, whereas the class III Arf6 localizes to the plasma membrane and is involved in endocytosis ( 2-4 ). (bioscience.org)
  • Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. (ucsc.edu)
  • Clathrin-mediated endocytosis is a major pathway by which proteins and membrane components are internalized into cells. (rupress.org)
  • After synaptic vesicle exocytosis during neural firing, the coordinated endocytosis of synaptic vesicle membrane proteins is mediated by adaptor proteins. (sdbonline.org)
  • These results suggest that the Stoned proteins are essential for the recycling of synaptic vesicle membrane and are required for the proper sorting of Synaptotagmin during endocytosis. (sdbonline.org)
  • In HeLa cells depleted of adaptor protein 2 complex (AP2) by small interfering RNA (siRNA) to the μ2 or α subunit or by transient overexpression of an AP2 sequestering mutant of Eps15, endocytosis of the transferrin receptor (TfR) was strongly inhibited. (asm.org)
  • However, epidermal growth factor (EGF)-induced endocytosis of the EGF receptor (EGFR) was inhibited only in cells where the α subunit had been knocked down. (asm.org)
  • This finding could potentially support the contention that clathrin-dependent endocytosis of the EGFR is independent of adaptor protein 2 (AP2), in contrast to clathrin-dependent endocytosis of the TfR ( 8 , 22 ). (asm.org)
  • Dynamics of clathrin and adaptor proteins during endocytosis. (dbcls.jp)
  • Intersectin 1 (ITSN1) is an adaptor protein involved in clathrin-mediated endocytosis, apoptosis, signal transduction and cytoskeleton organization. (genes2cognition.org)
  • 171 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) Antibodies from 23 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
  • Auf www.antikoerper-online.de finden Sie aktuell 17 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits von 5 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Recombinant protein fragment corresponding to amino acids 97-383 of human AP2M1 (NP_001020376) produced in E.coli. (novusbio.com)
  • Additionally, it was demonstrated that ALT inhibited cell proliferation, colony formation, autophagy, induced apoptosis and reduced tumor growth in vivo through upregulating the expression of adaptor related protein complex 2 subunit mu 1 (AP2M1). (biomedcentral.com)
  • AP2M1 encodes the μ-subunit of the adaptor protein complex 2 (AP-2), which belongs to the adaptor complexes medium subunits family. (biomedcentral.com)
  • Recombinant protein fragment corresponding to a region within amino acids 1 and 160 of Human AP2M1. (abcam.co.jp)
  • AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). (genecards.org)
  • AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. (genecards.org)
  • In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. (genecards.org)
  • Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. (uniprot.org)
  • Component of the adaptor complexes which link clathrin to receptors in coated vesicles. (xenbase.org)
  • Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. (wikipedia.org)
  • The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. (antibodies-online.com)
  • AP-1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. (vwr.com)
  • Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (embl.de)
  • This traffic is bidirectional, to ensure that proteins required to form vesicles are recycled. (embl.de)
  • Clathrin coats contain both clathrin and adaptor complexes that link clathrin to receptors in coated vesicles. (embl.de)
  • The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. (utsouthwestern.edu)
  • This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. (utsouthwestern.edu)
  • To address these issues, we have utilized the powerful new approach of subcellular proteomics to identify novel proteins present on highly enriched clathrin-coated vesicles (CCVs). (rupress.org)
  • 7 ), and it is becoming increasingly clear that specific interactions between recruited coat subunits and cargo proteins direct the incorporation of cargo into budding vesicles and that adaptor molecules other than AP2 can interact with phosphatidylinositol (PI) (4,5), P 2 and clathrin ( 1 ). (asm.org)
  • Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, l. (xenbase.org)
  • The Yxxphi motif is a sorting signal found in the cytosolic tail of various membrane proteins as an endocytic motif and also directs traffic within the endosomal and the secretory pathways. (eu.org)
  • This Y-based sorting signal directs the trafficking within the endosomal and the secretory pathways of integral membrane proteins by interacting with the mu subunits of the adaptor protein (AP) complex. (wikipedia.org)
  • Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. (vwr.com)
  • Failure to localize membrane proteins to the primary cilium causes a group of diseases collectively named ciliopathies. (biologists.org)
  • The medium (mu) adaptins of all AP complexes can recognise and interact with tyrosine-based (YXXphi) sorting signals found within the cytoplasmic tails of integral membrane proteins (Aguilar et al. (reactome.org)
  • It may also play a role in regulating the intracellular trafficking and function of CTLA-4 protein. (thefreedictionary.com)
  • The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. (genecards.org)
  • Intracellular traffic of many membrane-bound proteins requires sequences facing the cytoplasm. (eu.org)
  • Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. (antibodies-online.com)
  • In the current report, we utilized the intracellular protein-protein interaction reporter system, bimolecular fluorescence complementation (BiFC), in combination with super-resolution microscopy, to track the Nef/MHC-I interaction and determine its subcellular localization in cells. (nature.com)
  • Cdc42, a member of the Ras superfamily of small guanine nucleotide binding proteins, plays an important role in regulating the actin cytoskeleton, intracellular trafficking, and cell polarity. (genes2cognition.org)
  • The gene encoding the protein MUDENG (Mu-2 related death-inducing gene) was cloned and characterized. (nih.gov)
  • This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. (nih.gov)
  • This gene encodes a subunit of the heterotetrameric AP-4 complex. (genecards.org)
  • AP4M1 (Adaptor Related Protein Complex 4 Mu 1 Subunit) is a Protein Coding gene. (genecards.org)
  • Solute carrier family 46 member 3 (SLC46A3) is a protein that in humans is encoded by the SLC46A3 gene. (wikipedia.org)
  • Antigen standard for MU-2/AP1M2 domain containing, death-inducing (MUDENG), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
  • The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. (antibodies-online.com)
  • This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. (antibodies-online.com)
  • This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. (antibodies-online.com)
  • A gene on chromosome 5q14.1 that encodes a subunit of the heterotetrameric AP3 complex, a protein complex composed of two large subunits (delta and beta), a medium subunit (mu), and a small subunit (sigma). (thefreedictionary.com)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • An important gene associated with Generalized Epilepsy with Febrile Seizures Plus is SCN1B (Sodium Voltage-Gated Channel Beta Subunit 1), and among its related pathways/superpathways are Developmental Biology and G-Beta Gamma Signaling . (malacards.org)
  • The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. (utsouthwestern.edu)
  • This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. (ucsc.edu)
  • Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. (ucsc.edu)
  • A single Select transcript is chosen as representative for each protein-coding gene. (ucsc.edu)
  • The cDNA sequences are enriched in the following gene ontology functional categories: protein binding, hydrolase, transferase, and catalytic enzymes. (biomedcentral.com)
  • The FLCN gene encodes the protein folliculin (FLCN) which is 579 amino acids in length and has a mass of 64 kDa in humans. (frontiersin.org)
  • Among the ten novel proteins identified is the rat homologue of a predicted gene product from human, mouse, and Drosophila genomics projects, which we named enthoprotin. (rupress.org)
  • The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin 2 are evolutionarily conserved from worm to man, thereby identifying stonin 2 and its invertebrate homologs uncoordinated (UNC)-41 and stoned B as endocytic adaptors dedicated to the retrieval of surface-stranded SV proteins, most notably synaptotagmin. (nih.gov)
  • Contains 1 MHD (mu homology) domain. (abcam.com)
  • The signal-transducing adaptor protein 1 (STAP1) Src homology 2 (SH2) domain binding motif at Tyr446 - Ile450 (YELLI) is a phosphotyrosine (pTyr) pocket that serves as a docking site for the SH2 domain, which is central to tyrosine kinase signaling. (wikipedia.org)
  • There are three classes of mammalian Arf proteins, distinguished by size and homology ( 1 ). (bioscience.org)
  • This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. (ucsc.edu)
  • Although no sequence homology has been reported with other known proteins, FLCN is highly conserved across species, being 92% identical to its mouse ortholog, 28% identical to its D. melanogaster ortholog and 22% to the C. elegans ortholog. (frontiersin.org)
  • StnA is a novel protein without homology to known synaptic proteins, and StnB contains a domain with homology to the endocytotic protein AP50. (sdbonline.org)
  • Here, we investigate the exchange factor activity of the Dbl-homology domain containing constructs of the adaptor protein Intersectin1L (ITSN1L), which is a specific GEF for Cdc42. (genes2cognition.org)
  • Adaptins are clustered subunits of adaptor protein (AP) complexes. (wikipedia.org)
  • Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin. (wikipedia.org)
  • All AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). (embl.de)
  • This entry represents the small sigma and mu subunits of various adaptins from different AP clathrin adaptor complexes (including AP1, AP2, AP3 and AP4), and the zeta and delta subunits of various coatomer (COP) adaptors. (embl.de)
  • Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network. (nih.gov)
  • Adaptor protein 4 (AP-4) is the most recently discovered and least well-characterized member of the family of heterotetrameric adaptor protein (AP) complexes that mediate sorting of transmembrane cargo in post-Golgi compartments. (rcsb.org)
  • These findings demonstrate that APP and AP-4 engage in a distinct type of signal-adaptor interaction that mediates transport of APP from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. (rcsb.org)
  • This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. (genecards.org)
  • The complex is associated with the Golgi region as well as more peripheral structures. (genecards.org)
  • The protein encoded by AP1M1 is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. (antikoerper-online.de)
  • In the course of HCV protein production, there is disruption of the Golgi apparatus, loss of spatial organization of the ER, appearance of some "virus-like" structures and swelling of mitochondria. (biomedcentral.com)
  • AP3 plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes, as well as in biogenesis of melanosomes, platelet dense granules and lysosomes. (thefreedictionary.com)
  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. (rcsb.org)
  • The family of heterotetrameric adaptor protein (AP) complexes function as vesicle coat components, involved in targeting cargo proteins from post-Golgi compartments to the endosomal-lysosomal system. (reactome.org)
  • It can therefore bind to AP4M1 of the AP4 complex and subsequently, be transported from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. (reactome.org)
  • In previous work, we found that a complex named GARP is a critical component of the molecular machinery that mediates retrograde transport of various cargo proteins, including sorting receptors, processing endopeptidases, fusogenic proteins and bacterial and plant toxins, from endosomes to the trans-Golgi network in mammalian cells. (grantome.com)
  • We showed that the molecular function of this complex is to promote tethering and fusion of endosome-derived transport carriers to the trans-Golgi network. (grantome.com)
  • Interference with any of the GARP subunits blocks the delivery of many cargos to the trans-Golgi network, leading to global defects in lysosomal function, lipid traffic and autophagy. (grantome.com)
  • Enthoprotin interacts with the clathrin adaptors AP1 and with Golgi-localized, γ-ear-containing, Arf-binding protein 2. (rupress.org)
  • Furthermore, super-resolution imaging identified that the Nef:MHC-I BiFC complex transits through both early and late endosomes before ultimately residing at the trans-Golgi network. (nature.com)
  • The first model, termed the signaling mode of downregulation, is activated early during infection and involves the targeting of Nef to the trans-Golgi network (TGN) by the host membrane trafficking regulator protein phosphofurin acidic cluster sorting protein 2 (PACS-2) 2 , 7 . (nature.com)
  • Vacuolar storage proteins are sorted in the cis-cisternae of the pea cotyledon Golgi apparatus. (dbcls.jp)
  • The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (rcsb.org)
  • Collapsin response mediator proteins (CRMPs) mediate signal transduction of neurite outgrowth and axonal guidance during neuronal development. (biologists.org)
  • This protein is capable of interacting with tyrosine-based sorting signals. (nih.gov)
  • Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells. (nih.gov)
  • Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). (genecards.org)
  • This novel interaction is further substantiated by the presence of a known tyrosine-based adaptor protein MU subunit sorting signal sequence, YXXФ: where Ф is a bulky hydrophobic residue, which is conserved across the related RSV M proteins. (missouristate.edu)
  • AP-1, AP-2, and AP-3 are clathrin-associated adaptor complexes that recognize two types of sorting signal referred to as tyrosine-based and dileucine-based. (grantome.com)
  • Previous studies showed that tyrosine-based signals bind to the mu1, mu2 and mu3 subunits, whereas dileucine-based signals bind to a combination (i.e., a hemicomplex) of two subunits, gamma-sigma1, alpha-sigma2 and delta-sigma3, from the corresponding AP complexes. (grantome.com)
  • The AP-4 complex is distinct from the other AP complexes in that it does not recognize canonical tyrosine-based and dileucine-based signals. (grantome.com)
  • Biochemical and X-ray crystallographic analyses revealed that the properties of the APP sequence and the location of the binding site on mu4 are distinct from those of canonical tyrosine-based signals binding to the mu subunits of other AP complexes. (grantome.com)
  • Results indicate that AP-2 is not essential for clathrin -coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins. (antikoerper-online.de)
  • Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. (genecards.org)
  • Stonins--specialized adaptors for synaptic vesicle recycling and beyond? (nih.gov)
  • Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves as a linker between the endocytic proteins AP-2 and Eps15 and the calcium-sensing synaptic vesicle (SV) protein synaptotagmin 1. (nih.gov)
  • Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. (uniprot.org)
  • The AP4M1 belongs to a complex that mediates vesicle trafficking of glutamate receptors, being likely involved in brain development and neurotransmission. (biomedcentral.com)
  • Current work in our laboratory is aimed at elucidating the structure, regulation and physiological roles of coat proteins and vesicle tethering factors, and investigating human diseases that result from genetic defects (e.g. (grantome.com)
  • Adaptor proteins (APs) play key roles in this process by recruiting coat proteins and selecting cargos for different vesicle carriers. (plantphysiol.org)
  • Our study reveals the utility of proteomics in the identification of novel vesicle trafficking proteins. (rupress.org)
  • A variety of interactions between Ca 2+ channels and presynaptic proteins contribute to the molecular and mechanistic complexities of the vesicle release cycle and synaptic transmission ( Sudhof, 1995 ). (biologists.org)
  • Despite this slight structural difference, the mutant NMJs display clear, punctate expression of several vesicle-associated proteins in the synaptic boutons, including CSP and Syb. (sdbonline.org)
  • 7. The expression vector according to claim 5, wherein the recombinant nucleic acid according to claim 1 further comprises a protein coding sequence that encodes a reporter protein or a therapeutic protein. (freepatentsonline.com)
  • The human immunodeficiency virus type 1 (HIV-1) encodes a class of proteins that lack any known enzymatic activity. (nature.com)
  • The Drosophila stoned locus is dicistronic, that is, the locus encodes two distinctive presynaptic proteins, Stoned A (StnA) and Stoned B (StnB) from a single mRNA polymer. (sdbonline.org)
  • KAR9 encodes a novel 74-kD protein that is not essential for life. (rupress.org)
  • Assembly Protein Complex 2 Human Recombinant produced in E.Coli is a non-glycosylated, polypeptide chain containing amino acids (1-435) and having a total molecular mass of 50 kDa. (promab.com)
  • Recombinant funsion protein containing a sequence corresponding to amino acids 164-423 of human AP1M2 (NP_005489.2). (genetex.com)
  • AP1M2 is a subunit of the adaptor complex AP-1. (vwr.com)
  • Zusätzlich bieten wir Ihnen AP1M1 Kits (20) und AP1M1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • Orthologous to human AP1M1 (adaptor related protein complex 1 subunit mu 1). (jax.org)
  • AP1M1 (NP_115882, 1 a.a. ~ 74 a.a) partial recombinant protein with GST tag. (proteogenix-products.com)
  • The fifth adaptor protein complex. (nih.gov)
  • Herein, we report the interaction of an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP) with the mu4 subunit of AP-4. (rcsb.org)
  • Biochemical and X-ray crystallographic analyses reveal that the properties of the APP sequence and the location of the binding site on mu4 are distinct from those of other signal-adaptor interactions. (rcsb.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • 8. An isolated host cell comprising the expression vector of claim 5 wherein the expression vector of claim 5 comprises a protein coding sequence, and the host cell transiently or encoded in the expression vector of claim 5. (freepatentsonline.com)
  • 9. An isolated host cell which is obtained by in vivo injection of the expression vector of claim 5 into a cell, wherein the expression vector of claim 5 comprises a protein coding sequence, and the host cell comprises the expression vector of claim 5 and transiently or encoded in the expression vector of claim 5. (freepatentsonline.com)
  • Recombinant protein encompassing a sequence within the center region of human AP4M1. (genetex.com)
  • The protein sequence contains mixed, positive, and negative charge clusters, one of each, which are high in glutamine (Glu). (wikipedia.org)
  • MISCAST is an interactive and user-friendly web server to visualize and analyze missense variants in protein sequence and structure space. (uni.lu)
  • Analysis of point-mutated HRSV M derivatives indicated that AP-3Mu3A- mediated trafficking is contingent on the presence of the tyrosine residue within the YXXL sorting sequence at amino acids 197-200 of the M protein. (missouristate.edu)
  • Using the same cutoff, approximately 67% of the cDNAs have a BLAST hit in the NCBI non-redundant protein and nucleotide sequence databases (nr and nt), suggesting that one third of the sequences may be unique to L. stagnalis . (biomedcentral.com)
  • The location and topography of the corresponding sites are similar, although the strength and amino acid requirements of different interactions depend on the exact sequence of the signal and the particular AP complex involved. (grantome.com)
  • We recently found that, instead, the mu4 subunit of AP-4 binds an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP). (grantome.com)
  • Motif conserving the exact sequence KEN that binds to the APC/C subunit Cdh1 causing the protein to be targeted for 26S proteasome mediated degradation. (eu.org)
  • Few studies however have simultaneously characterized the impact of within-host nef sequence evolution on Nef protein function over prolonged timescales. (springer.com)
  • Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells. (nih.gov)
  • IRS-1 (zeige IRS1 Antikörper ) associates with mu1A of the ubiquitously expressed AP-1 (zeige FOSB Antikörper ) complex through three protein interaction motifs. (antikoerper-online.de)
  • Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit. (eu.org)
  • The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4(+) T cell apoptosis. (ptglab.com)
  • We demonstrate that this interaction is mediated by the AP-2 mu subunit (Apm4) YXXΦ binding domain. (asm.org)
  • Interaction of the human respiratory Syncytial virus matrix protein wi" by Casey Ward, Maciej Maselko et al. (missouristate.edu)
  • This novel protein-protein interaction was first detected via yeast-two hybrid screen and was further confirmed in a mammalian system by immunofluorescence colocalization and co-immunoprecipitation. (missouristate.edu)
  • This degron overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4 Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. (eu.org)
  • This degron, occurring in non-Vertebrates, overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4 Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. (eu.org)
  • Since the evidence for physical interaction between Stoned proteins and Synaptotagmin has now gained acceptence, it is interesting to look back at the genetic evidence for an involvement of Stoned proteins in the recycling of Synaptogamin. (sdbonline.org)
  • The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. (mybiosource.com)
  • The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. (mybiosource.com)
  • This is the case for the subunits of the heterotetrameric adaptor protein complex 4 (AP-4). (biomedcentral.com)
  • The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. (abcam.com)
  • This short C-terminal motif is present in co-activators, the Doc1/APC10 subunit and some substrates of the APC/C and mediates direct binding to TPR-containing APC/C core subunits. (eu.org)
  • The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. (uniprot.org)
  • Sorting is mediated by recognition of signals present in the cytosolic domains of the transmembrane proteins by adaptor proteins that are components of membrane coats (e.g., clathrin coats). (grantome.com)
  • Defects in formation of the complex or in its ability to interact directly with cargo inhibit enzyme uptake and lead to defective cell walls and aberrant hyphal morphology. (asm.org)
  • Based on our work, we hypothesize that defects in these diseases are caused by abnormal sorting of specific cargo proteins having dileucine-based signals. (grantome.com)
  • Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole. (mybiosource.com)
  • Cargo sorting is essential for plant survival and therefore necessitates complex molecular machinery. (plantphysiol.org)
  • As examined by electron microscopy, HCV proteins induced formation of large electron-dense cytoplasmic structures derived from the ER and containing HCV proteins. (biomedcentral.com)
  • 1999). The amyloid precursor protein (APP), implicated in Alzheimer's disease, contains such a signal in its cytoplasmic tail. (reactome.org)
  • Interestingly, Nef, AP-1 and MHC-I have been described to form a ternary complex which depends on the cytoplasmic tail of MHC-I 10 . (nature.com)
  • We propose that Kar9p is a component of a cortical adaptor complex that orients cytoplasmic microtubules. (rupress.org)
  • The cytoplasmic microtubules can then interdigitate, and the nuclei are drawn together in a microtubule-dependent manner by the Kar3p kinesin-like motor protein. (rupress.org)
  • AP50 is a subunit of the plasma membrane adaptor. (xenbase.org)
  • The complex binds polyphosphoinositide-containing lipids. (xenbase.org)
  • The highly-conserved Notch signaling pathway is unique, as both the Notch receptor and most of its respective ligands (canonically the DSL or Delta/Serrate/lag-2 family members) are transmembrane proteins attached to the cell surface. (antibodies-online.com)
  • We investigate the molecular mechanisms by which transmembrane proteins are sorted to different compartments of the endomembrane system such as endosomes, lysosomes and a group of cell-type-specific organelles known as lysosome-related organelles (e.g., melanosomes and platelet dense bodies). (grantome.com)
  • AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. (mybiosource.com)
  • AP4M1 antibody [N1C1] detects AP4M1 protein at cytoplasm in mouse testis by immunohistochemical analysis. (genetex.com)
  • V1H can function as an adaptor for interactions between Nef and AP-2 (zeige GTF3A ELISA Kits ). (antikoerper-online.de)
  • The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
  • RGS9-2 acts via a complex mechanism that involves interactions with Gα subunits, the Gβ5 protein, and the adaptor protein R7BP. (sigmaaldrich.com)
  • To date, knowledge of viral and host protein interactions within HRSV is limited and are critical areas of research. (missouristate.edu)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). (genecards.org)
  • The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. (mybiosource.com)
  • Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (nih.gov)
  • All genes encoding for the proteins part of this complex have been associated with genetic forms of HSP (e.g. (biomedcentral.com)
  • The NCBI RefSeq Genes composite track shows human protein-coding and non-protein-coding genes taken from the NCBI RNA reference sequences collection (RefSeq). (ucsc.edu)
  • We also demonstrated the occurrence of multiple AP-1 complexes resulting from combinatorial assembly of various gamma (i.e., gamma1 and gamma2) and sigma1 (i.e., sigma1A, sigma1B and sigma1C) subunit isoforms encoded by different genes. (grantome.com)
  • Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
  • The encoded protein belongs to the adaptor complexes medium subunits family. (genecards.org)
  • Also referred to as FKSG16, the protein belongs to the major facilitator superfamily (MFS) and SLC46A family. (wikipedia.org)
  • The HIV accessory protein Nef downregulates the viral entry receptor CD4, the Human Leukocyte Antigen (HLA)-A and -B molecules, the Serine incorporator 5 (SERINC5) protein and other molecules from the infected cell surface, thereby promoting viral infectivity, replication and immune evasion. (springer.com)
  • Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (nih.gov)
  • Viral proteins recruit and interact with cellular trafficking proteins to divert the normal trafficking of key proteins or to induce the formation of novel membrane structures in the host cell. (bioscience.org)
  • Two APP-like proteins, APLP1 and APLP2, have related sequences that also interact with mu4. (grantome.com)
  • A hydrophobic degron motif present in some kainate receptors necessary to interact with kelch domain of actinfilin protein for efficient ubiquitination and degradation. (eu.org)
  • An Acidic degron motif present in wnk kinases necessary to interact with kelch domain of KLHL2 and KLHL3 proteins for efficient ubiquitination degradation. (eu.org)
  • Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
  • Wild-type and mutant embryos (22-24 hr) were labeled with each of the Stoned antibodies to determine the effect of each mutation on protein expression and localization. (sdbonline.org)
  • Your search returned 14 adaptor related protein complex 3 subunit mu 1 ELISA ELISA Kit across 2 suppliers. (biocompare.com)
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • The basic patch on micro1 that interacts with the Nef acidic cluster also contributes to the binding of endogenous acidic cluster proteins. (antikoerper-online.de)
  • The Yxxphi motif interacts with mu subunit of AP (Adaptor Protein) complex. (eu.org)
  • Here, we show that HRSV Matrix (M) protein interacts with the cellular adaptor protein complex 3 specifically via its medium subunit (AP-3Mu3A). (missouristate.edu)
  • It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). (genecards.org)
  • The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity). (genecards.org)
  • The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). (uniprot.org)
  • In this model, we observed that HCV proteins control cellular translation through eIF-2α-S51 phosphorylation, with involvement of the double-stranded RNA-dependent protein kinase PKR. (biomedcentral.com)
  • Binding of TSH to the TSHR, a member of the GPCR superfamily, leads to the activation of G proteins and, in response to receptor phosphorylation, the activation of β-arrestin-dependent signaling. (sciencemag.org)
  • Hence, agonist binding to the TSHR activates a number of different G proteins and results in receptor phosphorylation ( 6 , 7 ) through GPCR kinases (GRKs). (sciencemag.org)
  • The LIS1 accessory protein directly binds dynein, although its precise role in regulating dynein remains unclear. (sdbonline.org)
  • The HIV-1 accessory proteins Nef and Vpu alter cell surface levels of multiple host proteins to modify the immune response and increase viral persistence. (biomedcentral.com)
  • While Nef and Vpu are arguably the most extensively studied accessory proteins, their roles in T cell activation are not fully understood. (biomedcentral.com)
  • Specifically, MHC-I downregulation by the HIV-1 accessory protein Nef is of critical importance in preventing infected cells from cytotoxic T-cell mediated killing. (nature.com)
  • Accessory proteins can promote viral fitness by allowing infected cells to evade the host immune response 1 . (nature.com)
  • Proteins required for nutrient uptake or cell wall biosynthesis in the new environment are incorporated into the plasma membrane via the secretory pathway. (asm.org)
  • Part of the AP-3 complex, an adaptor-related complex which is essential for the compartmentalization of the endocytic pathway. (mybiosource.com)
  • Overexpression of Grb2 with inactivating point mutations in N- or C-terminal SH3 domains or in both SH3 domains inhibited EGF-induced formation of coated pits efficiently, even though Grb2 SH3 mutations did not block activation of mitogen-activated protein kinase (MAPK) or phosphatidylinositol 3-kinase (PI3K). (asm.org)