Adaptor Protein Complex mu Subunits: A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.Adaptor Protein Complex 3: An adaptor protein complex found primarily on perinuclear compartments.Adaptor Protein Complex 1: A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.Adaptor Protein Complex 2: An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.Adaptor Protein Complex 4: An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.Adaptor Protein Complex Subunits: The subunits that make up the large, medium and small chains of adaptor proteins.Adaptor Protein Complex delta Subunits: A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.Adaptor Proteins, Vesicular Transport: A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.Adaptor Protein Complex gamma Subunits: A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.Adaptor Protein Complex beta Subunits: A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.Adaptor Protein Complex alpha Subunits: A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesClathrin: The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.Human Characteristics: The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)Monomeric Clathrin Assembly Proteins: A subclass of clathrin assembly proteins that occur as monomers.GRB2 Adaptor Protein: A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).Shc Signaling Adaptor Proteins: A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL SURFACE RECEPTORS to MITOGEN-ACTIVATED PROTEIN KINASES.Adaptor Protein Complex sigma Subunits: A family of small adaptin protein complex subunits of approximately 19 KDa in size.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Protein Subunits: Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.Endocytosis: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Coated Vesicles: Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
(1/92) Phosphorylation of the medium chain subunit of the AP-2 adaptor complex does not influence its interaction with the tyrosine based internalisation motif of TGN38.

Tyrosine based motifs conforming to the consensus YXXphi (where phi represents a bulky hydrophobic residue) have been shown to interact with the medium chain subunit of clathrin adaptor complexes. These medium chains are targets for phosphorylation by a kinase activity associated with clathrin coated vesicles. We have used the clathrin coated vesicle associated kinase activity to specifically phosphorylate a soluble recombinant fusion protein of mu2, the medium chain subunit of the plasma membrane associated adaptor protein complex AP-2. We have tested whether this phosphorylation has any effect on the interaction of mu2 with the tyrosine based motif containing protein, TGN38, that has previously been shown to interact with mu2. Phosphorylation of mu2 was shown to have no significant effect on the in vitro interaction of mu2 with the cytosolic domain of TGN38, indicating that reversible phosphorylation of mu2 does not play a role in regulating its direct interaction with tyrosine based internalisation motifs. In addition, although a casein kinase II-like activity has been shown to be associated with clathrin coated vesicles, we show that mu2 is not phosphorylated by casein kinase II implying that another kinase activity is present in clathrin coated vesicles. Furthermore the kinase activity associated with clathrin coated vesicles was shown to be capable of phosphorylating dynamin 1. Phosphorylation of dynamin 1 has previously been shown to regulate its interaction with other proteins involved in clathrin mediated endocytosis.  (+info)

(2/92) Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.

Although interactions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based internalization motifs have been implicated in the selective recruitment of cargo molecules into coated pits, the functional significance of this interaction for endocytosis of many types of membrane proteins remains unclear. To analyze the function of mu2-receptor interactions, we constructed an epitope-tagged mu2 that incorporates into AP-2 and is targeted to coated pits. Mutational analysis revealed that Asp176 and Trp421 of mu2 are involved in the interaction with internalization motifs of TGN38 and epidermal growth factor (EGF) receptor. Inducible overexpression of mutant mu2, in which these two residues were changed to alanines, resulted in metabolic replacement of endogenous mu2 in AP-2 complexes and complete abrogation of AP-2 interaction with the tyrosine-based internalization motifs. As a consequence, endocytosis of the transferrin receptor was severely impaired. In contrast, internalization of the EGF receptor was not affected. These results demonstrate the potential usefulness of the dominant-interfering approach for functional analysis of the adaptor protein family, and indicate that clathrin-mediated endocytosis may proceed in both a mu2-dependent and -independent manner.  (+info)

(3/92) Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells.

The apical and basolateral plasma membrane domains of polarized epithelial cells contain distinct sets of integral membrane proteins. Biosynthetic targeting of proteins to the basolateral plasma membrane is mediated by cytosolic tail determinants, many of which resemble signals involved in the rapid endocytosis or lysosomal targeting. Since these signals are recognized by adaptor proteins, we hypothesized that there could be epithelial-specific adaptors involved in polarized sorting. Here, we report the identification of a novel member of the adaptor medium chain family, named mu1B, which is closely related to the previously described mu1A (79% amino acid sequence identity). Northern blotting and in situ hybridization analyses reveal the specific expression of mu1B mRNA in a subset of polarized epithelial and exocrine cells. Yeast two-hybrid analyses show that mu1B is capable of interacting with generic tyrosine-based sorting signals. These observations suggest that mu1B may be involved in protein sorting events specific to polarized cells.  (+info)

(4/92) A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells.

Although polarized epithelial cells are well known to maintain distinct apical and basolateral plasma membrane domains, the mechanisms responsible for targeting membrane proteins to the apical or basolateral surfaces have remained elusive. We have identified a novel form of the AP-1 clathrin adaptor complex that contains as one of its subunits mu1B, an epithelial cell-specific homolog of the ubiquitously expressed mu1A. LLC-PK1 kidney epithelial cells do not express mu1B and missort many basolateral proteins to the apical surface. Stable expression of mu1B selectively restored basolateral targeting, improved the overall organization of LLC-PK1 monolayers, and had no effect on apical targeting. We conclude that basolateral sorting is mediated by an epithelial cell-specific version of the AP-1 complex containing mu1B.  (+info)

(5/92) mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors.

The heterotetrameric AP-1 complex is involved in the formation of clathrin-coated vesicles at the trans-Golgi network (TGN) and interacts with sorting signals in the cytoplasmic tails of cargo molecules. Targeted disruption of the mouse mu1A-adaptin gene causes embryonic lethality at day 13.5. In cells deficient in micro1A-adaptin the remaining AP-1 adaptins do not bind to the TGN. Polarized epithelial cells are the only cells of micro1A-adaptin-deficient embryos that show gamma-adaptin binding to membranes, indicating the formation of an epithelial specific AP-1B complex and demonstrating the absence of additional mu1A homologs. Mannose 6-phosphate receptors are cargo molecules that exit the TGN via AP-1-clathrin-coated vesicles. The steady-state distribution of the mannose 6-phosphate receptors MPR46 and MPR300 in mu1A-deficient cells is shifted to endosomes at the expense of the TGN. MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor.  (+info)

(6/92) Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif.

HIV-1 Nef interacts with cellular adaptor protein (AP) complexes and their medium (mu) subunits. However, the role of the dileucine-based sorting motif within Nef in these interactions has been incompletely characterized. Here, yeast two-hybrid assays indicated that HIV-1 Nef interacted not only with the mu subunits of AP-1 and AP-2, but also with that of AP-3. The interactions with mu1 and mu3 were markedly stronger than the interaction with mu2. Leucine residues of the sorting motif were required for the interactions with mu3 and mu2 and contributed to the interaction with mu1. Confocal immunofluorescence microscopy indicated that Nef, AP-1, and AP-3 (but not AP-2) were concentrated in a juxtanuclear region near the cell center, potentially facilitating interaction between Nef and the mu1 and mu3 subunits. However, leucine residues of the sorting motif were not required for this subcellular localization of Nef. These data suggest that the dileucine motif, required for optimal viral replication, functions through interactions with a variety of AP complexes, including AP-3, potentially by recruiting adaptor complexes to subcellular locations specified by additional determinants in the Nef protein.  (+info)

(7/92) RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis.

RLIP76 is a modular protein that was identified as a putative effector of Ral, a GTPase activated during Ras signaling. To explore further the contribution of the Ral-RLIP76 pathway to Ras signaling, we have looked for partners of RLIP76. Mu2, the medium chain of the AP2 complex is shown to interact with RLIP76. We show also that in vivo endogenous AP2 and RLIP76 form a complex and that this in vivo interaction is independent of cells being stimulated by a growth factor. Furthermore, RLIP76 differentiates AP2 from AP1 in vivo as RLIP76 differentiates mu2 from mu1 in vitro and in two hybrid assays. We show that activated Ral interferes with both tranferrin receptor endocytosis and epidermal growth factor (EGF) receptor endocytosis in HeLa cells. We propose a model where the Ral-RLIP76 pathway connects signal transduction and endocytosis through interaction on one hand between the Ras-Ral pathway and RLIP, on the other hand between RLIP and proteins belonging to the endocytotic machinery.  (+info)

(8/92) Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans.

In the nematode Caenorhabditis elegans, there exist two micro1 medium chains of the AP-1 clathrin-associated protein complex. Mutations of unc-101, the gene that encodes one of the micro1 chains, cause pleiotropic effects (). In this report, we identified and analyzed the second mu1 chain gene, apm-1. Unlike the mammalian homologs, the two medium chains are expressed ubiquitously throughout development. RNA interference (RNAi) experiments with apm-1 showed that apm-1 and unc-101 were redundant in embryogenesis and in vulval development. Consistent with this, a hybrid protein containing APM-1, when overexpressed, rescued the phenotype of an unc-101 mutant. However, single disruptions of apm-1 or unc-101 have distinct phenotypes, indicating that the two medium chains may have distinct functions. RNAi of any one of the small or large chains of AP-1 complex (sigma1, beta1, or gamma) showed a phenotype identical to that caused by the simultaneous disruption of unc-101 and apm-1, but not that by single disruption of either gene. This suggests that the two medium chains may share large and small chains in the AP-1 complexes. Thus, apm-1 and unc-101 encode two highly related micro1 chains that share redundant and distinct functions within AP-1 clathrin-associated protein complexes of the same tissue.  (+info)

*  AP3D1
"Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting ... AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene. AP3D1 is a subunit of the AP3 adaptor- ... "Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit". Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J ... "Characterization of the adaptor-related protein complex, AP-3". The Journal of Cell Biology. 137 (4): 835-45. doi:10.1083/jcb. ...
*  AP3M1
"Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... AP-3 complex subunit mu-1 is a protein that in humans is encoded by the AP3M1 gene. The protein encoded by this gene is the ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ... AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a ...
*  AP1M1
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... "Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules". ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
*  AP4M1
"Entrez Gene: AP4M1 adaptor-related protein complex 4, mu 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene. This gene encodes a subunit of the ... The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition ... 2001). "Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4". J. Biol. Chem. 276 (16): 13145-52. ...
*  AP2M1
"Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit". Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, ... AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene. This gene encodes a subunit of the ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ...
*  Adaptor complexes medium subunit domain
In molecular biology, the adaptor complexes medium subunit domain is a protein domain found at the C-terminus of the mu subunit ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ... The mu subunit regulates the coupling of clathrin lattices with particular membrane proteins by self-phosphorylation via a ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". The ...
*  CTLA-4
"Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ... The CTLA-4 protein is encoded by the Ctla4 gene in mice and the CTLA4 gene in humans. In 1987, cytotoxic T-lymphocyte antigen 4 ... The fusion protein CTLA4-Ig is commercially available as Orencia (abatacept). A second generation form of CTLA4-Ig known as ... CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and ...
*  AP1M2
"Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot ... AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene. This gene encodes a subunit of the ... heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This ... sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in ...
*  Adaptor-related protein complex 2, alpha 1
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ...
*  List of adaptins
Adaptins are clustered subunits of adaptor protein (AP) complexes.. There are several types of adaptin, each related to a ... mu), and a small adaptin (sigma): complex 1 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 complex 2 AP2A1 AP2A2 AP2B1 AP2M1 ... 2011) The Fifth Adaptor Protein Complex. PLoS Biol 9(10): e1001170. doi:10.1371/journal.pbio.1001170. ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". ncbi. ...
*  Clathrin adaptor protein
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ... The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and ...
*  B2-adapt-app C
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
*  Vesicular transport adaptor protein
... mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 corresponding to the 5 AP complexes. Components of COPI ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ... but not closely related to the AP/TSET complexes. The individual proteins of the COPII complex are called SEC proteins, because ...
*  AP4B1
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...
*  AP4S1
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. The heterotetrameric adaptor protein (AP ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ... Dell'Angelica EC, Mullins C, Bonifacino JS (1999). "AP-4, a novel protein complex related to clathrin adaptors". J. Biol. Chem ...
*  AP4E1
AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (AP4M1), and a small ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
*  AAK1
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly ... "Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals". The Journal ... The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals ... Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the ...
*  List of MeSH codes (D12.776.543)
... adaptor protein complex gamma subunits MeSH D12.776.543.990.150.500.500 -- adaptor protein complex mu subunits MeSH D12.776. ... adaptor protein complex alpha subunits MeSH D12.776.543.990.150.500.200 -- adaptor protein complex beta subunits MeSH D12.776. ... adaptor protein complex 4 MeSH D12.776.543.990.150.500 -- adaptor protein complex subunits MeSH D12.776.543.990.150.500.100 -- ... adaptor protein complex 1 MeSH D12.776.543.990.150.200 -- adaptor protein complex 2 MeSH D12.776.543.990.150.300 -- adaptor ...
*  AP1S1
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ...
*  Importin
As part of a heterodimer, importin-β mediates interactions with the pore complex, while importin-α acts as an adaptor protein ... Kim IS, Kim DH, Han SM, Chin MU, Nam HJ, Cho HP, Choi SY, Song BJ, Kim ER, Bae YS, Moon YH (July 2000). "Truncated form of ... Görlich D, Kostka S, Kraft R, Dingwall C, Laskey RA, Hartmann E, Prehn S (April 1995). "Two different subunits of importin ... but the key proteins involved had not been elucidated up until that point. A 60kDa cytosolic protein, essential for protein ...
*  Doublecortin
2001). "Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system". Mol. Cell. ... Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X is a protein that in humans is encoded by ... Doublecortin is a basic protein with an iso-electric point of 10, typical of microtubule-binding proteins. In mice where the ... These domains are found in the N terminus of proteins and consists of tandemly repeated copies of an around 80 amino acids ...
*  Allograft inflammatory factor 1
... (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in ... Hung AY, Sheng M (February 2002). "PDZ domains: structural modules for protein complex assembly". J. Biol. Chem. 277 (8): 5699- ... Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products ... Autieri MV, Carbone C, Mu A (July 2000). "Expression of allograft inflammatory factor-1 is a marker of activated human vascular ...
*  NEDD9
... may interact directly with APC subunit APC10 and thus recruit the APC complex. CDH1 subunit of the APC complex recognizes NEDD9 ... "Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease" (Oncoscience ... Wang H, Mu X, Zhou S, Zhang J, Dai J, Tang L, Xiao L, Duan Z, Jia L, Chen S (2014). "NEDD9 overexpression is associated with ... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ...
*  Fc receptor
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. The Fc-gamma receptors differ ... An Fc receptor is a protein found on the surface of certain cells - including, among others, B lymphocytes, follicular ...
*  IL1RAP
Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP ... 1995). "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex". J. Biol. Chem. 270 ( ... Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in ... Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene. Interleukin 1 induces ...
*  DNA
... operates as part of a large protein complex with multiple regulatory and accessory subunits. A DNA helix usually does not ... Nature 175 (4451) 336-337 Allet B, Bukhari AI (1975) Analysis of bacteriophage Mu and λ-Mu hybrid DNAs by specific ... and proteins, and articulated the "adaptor hypothesis". Final confirmation of the replication mechanism that was implied by the ... Within chromosomes, DNA is held in complexes with structural proteins. These proteins organize the DNA into a compact structure ...
Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits  Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits
... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... AP-2 complex subunit mu-1-A , AP-2 complex subunit mu-A , AP-2 mu-2 chain A , AP-2 mu-A chain , adaptor protein complex AP-2, ... adaptor related protein complex 2 mu 1 subunit (AP2M1) Elisa Kit * adaptor-related protein complex 2, mu 1 subunit, a (ap2m1a) ... adaptor-related protein complex 2, mu 1 subunit (Ap2m1) Elisa Kit * adaptor related protein complex 2 mu 1 subunit L homeolog ( ...
more infohttp://www.antikoerper-online.de/egfr-signaling-pathway-pathway-26/ap2m1-elisa-kit-1886/
Adaptor protein complex AP-2 subunit mu | definition of Adaptor protein complex AP-2 subunit mu by Medical dictionary  Adaptor protein complex AP-2 subunit mu | definition of Adaptor protein complex AP-2 subunit mu by Medical dictionary
Adaptor protein complex AP-2 subunit mu explanation free. What is Adaptor protein complex AP-2 subunit mu? Meaning of Adaptor ... protein complex AP-2 subunit mu medical term. What does Adaptor protein complex AP-2 subunit mu mean? ... Looking for online definition of Adaptor protein complex AP-2 subunit mu in the Medical Dictionary? ... Adaptor protein complex AP-2 subunit mu , definition of Adaptor protein complex AP-2 subunit mu by Medical dictionary https:// ...
more infohttp://medical-dictionary.thefreedictionary.com/Adaptor+protein+complex+AP-2+subunit+mu
AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens (human)] - Gene - NCBI  AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens (human)] - Gene - NCBI
adaptor protein complex AP-1 mu-2 subunit. adaptor related protein complex 1 mu 2 subunit. clathrin assembly protein complex 1 ... AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens] AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo ... clathrin-associated adaptor medium chain mu2. golgi adaptor AP-1 47 kDa protein. golgi adaptor HA1/AP1 adaptin mu-2 subunit. mu ... General protein information Go to the top of the page Help Preferred Names. AP-1 complex subunit mu-2. Names. AP-mu chain ...
more infohttps://www.ncbi.nlm.nih.gov/gene/10053
AP4M1 Gene - GeneCards | AP4M1 Protein | AP4M1 Antibody  AP4M1 Gene - GeneCards | AP4M1 Protein | AP4M1 Antibody
Protein Coding), Adaptor Related Protein Complex 4 Mu 1 Subunit, including: function, proteins, disorders, pathways, orthologs ... AP4M1 (Adaptor Related Protein Complex 4 Mu 1 Subunit) is a Protein Coding gene. Diseases associated with AP4M1 include Spastic ... AP4M1 Gene(Protein Coding) Adaptor Related Protein Complex 4 Mu 1 Subunit. ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=AP4M1
AP3M1 Gene - GeneCards | AP3M1 Protein | AP3M1 Antibody  AP3M1 Gene - GeneCards | AP3M1 Protein | AP3M1 Antibody
Protein Coding), Adaptor Related Protein Complex 3 Mu 1 Subunit, including: function, proteins, disorders, pathways, orthologs ... AP3M1 (Adaptor Related Protein Complex 3 Mu 1 Subunit) is a Protein Coding gene. Among its related pathways are Chaperonin- ... AP3M1 Gene(Protein Coding) Adaptor Related Protein Complex 3 Mu 1 Subunit. ... Protein Symbol:. Q9Y2T2-AP3M1_HUMAN. Recommended name:. AP-3 complex subunit mu-1 Protein Accession:. Q9Y2T2. Secondary ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=AP3M1
Produktübersicht anti-AP1M1 Antikörper  Produktübersicht anti-AP1M1 Antikörper
... adaptor protein complex AP-1 mu-1 subunit , adaptor-related protein complex 1 mu-1 subunit , clathrin adaptor protein AP47 , ... anti-Adaptor-Related Protein Complex 3, mu 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 3, mu 2 Subunit ... anti-Adaptor-Related Protein Complex 4, mu 1 Subunit Antikörper * anti-Adaptor-Related Protein Complex 5, mu 1 Subunit ... adaptor-related protein complex 1, mu 1 subunit (Ap1m1) Antikörper * adaptor-related protein complex AP-1, mu subunit 1 (Ap1m1 ...
more infohttps://www.antikoerper-online.de/abstract/Adaptor-Related+Protein+Complex+1%2C+mu+1+Subunit+
ELM - Detail for TRG ENDOCYTIC 2  ELM - Detail for TRG ENDOCYTIC 2
Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex ... Yxxphi sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex ... The Yxxphi motif interacts with mu subunit of AP (Adaptor Protein) complex. ... Transmembrane Receptor Protein Tyrosine Kinase Adaptor Protein (also annotated in these classes: LIG_AP2alpha_1 ) ...
more infohttp://elm.eu.org/elms/TRG_ENDOCYTIC_2.html
Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy.  - PubMed - NCBI  Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy. - PubMed - NCBI
AP4M1, encoding for the mu subunit of the adaptor protein complex-4, is involved in intracellular trafficking of glutamate ... α-V5 as well as α-AP4M1_lupin antibodies visualized an expected protein band of 50 kDa from the wild-type cDNA construct and a ... Adaptor Protein Complex 4. *Adaptor Protein Complex mu Subunits. Secondary source ID. *GEO/GSE16447 ... Adaptor Protein Complex 4/genetics*. *Adaptor Protein Complex mu Subunits/genetics*. *Brain/pathology ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19559397?dopt=Abstract
Gene Expression Literature Summary - MGI  Gene Expression Literature Summary - MGI
adaptor-related protein complex 3, mu 2 subunit. MGI:1929214 1 matching records from 1 references.. Summary by Age and Assay: ... Ap3m2 adaptor-related protein complex 3, mu 2 subunit (Synonyms: 5830445E16Rik, AP-3B) ...
more infohttp://www.informatics.jax.org/gxdlit/marker/MGI:1929214
Gene Info  Gene Info
adaptor-related protein complex 3, mu 1 subunit. 6169822. Full Length. BC067127. adaptor-related protein complex 3, mu 1 ... BP] protein targeting to lysosome *[CC] Golgi apparatus *[CC] clathrin adaptor complex *[CC] lysosome *[MF] protein binding ... Protein Similarities Based on Shared Motif Content. Find gene products sharing protein motifs with: NP_036227 NP_996895 Protein ... AP3M1, adaptor-related protein complex 3, mu 1 subunit. Sequence ID:. NM_012095. NM_207012. ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=500104&LLNO=26985
GO Gene List  GO Gene List
Adaptor-related protein complex 2, mu 1 subunit. NM_004068. NM_001025205. Gene Info. ... Adaptor-related protein complex 2, alpha 2 subunit. NM_001242837. NM_012305. Gene Info. ... ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9). NM_005175. NM_001002027. Gene Info. ... ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9). NM_001002031. NM_005176. Gene Info. ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0008289
AP2M1 Antibody (OTI1E9) [DyLight 488] (NBP2-70417G): Novus Biologicals  AP2M1 Antibody (OTI1E9) [DyLight 488] (NBP2-70417G): Novus Biologicals
adaptor-related protein complex 2, mu 1 subunit. *AP-2 mu chain ... Plasma membrane adaptor AP-2 50 kDa protein. *plasma membrane ... Recombinant protein fragment corresponding to amino acids 97-383 of human AP2M1 (NP_001020376) produced in E.coli. ... Clathrin assembly protein complex 2 medium chain. *clathrin coat adaptor protein AP50 ... Clathrin coat assembly protein AP50. *Clathrin coat-associated protein AP50. *clathrin-associated/assembly/adaptor protein, ...
more infohttps://www.novusbio.com/products/ap2m1-antibody-oti1e9_nbp2-70417g
Expression of AP1M1 in cancer - Summary - The Human Protein Atlas  Expression of AP1M1 in cancer - Summary - The Human Protein Atlas
The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... Adaptor related protein complex 1 mu 1 subunit. Protein classi. Protein class the gene product belongs to according to selected ... AP-1 complex subunit mu-1 A0A024R7K8 [Target identity:100%; Query identity:100%]. Adaptor-related protein complex 1, mu 1 ... Adaptor related protein complex 1 mu 1 subunit (HGNC Symbol). Entrez gene summary. The protein encoded by this gene is the ...
more infohttp://www.proteinatlas.org/ENSG00000072958-AP1M1/pathology
SMART: Pfam domain Adap comp sub  SMART: Pfam domain Adap comp sub
Mu subunits of adaptor protein (AP) complexes, AP-1, AP-2, AP-3, and AP-4. ... The mu homology domain (MHD) is an ~280 residue protein-protein interaction module, which is found in endocytotic proteins ... Proteins of the muniscin family: Syp1, FCHO1/2 and SGIP1.. The MHD domain has an elongated, banana-shaped, all beta-sheet ...
more infohttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=Pfam:Adap_comp_sub&START=396&END=711&E_VALUE=2.1e-64&TYPE=PFAM&BLAST=ATAKPKNKSYEEQEICLDIQDSLWGKVTKEGQLVESAVVTQICCLCFLNGPAECFLALNDRELQKRDECYFEKEPEKKGIAILDYHFHTCVKAEEFEQSRIIKFVPLDACRFELMRFKTSYEAGELPFAVKSVVTVQGAYVELQAFVNMTPAAQGSPHAGALRSCNNIMIHFPVPAQWIKALWTRNLQRQKSLKAKMNRRACLGSLQEPESEPVIQVTVGSAKYESAYRAVVWKIDRLPDKNSSPDQPHCLSYKLELGSDQEVPSDWYPFATVQFSMLEACASRTEVRSLGVESDAQPQKHVCQRACYNIQVEIEK
Anti-AP3M1 antibody (ab113104) | Abcam  Anti-AP3M1 antibody (ab113104) | Abcam
Adapter-related protein complex 3 mu-1 subunit antibody. *AP-3 adapter complex mu3A subunit antibody ... Belongs to the adaptor complexes medium subunit family.. Contains 1 MHD (mu homology) domain. ... Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi ... The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/ ...
more infohttp://www.abcam.com/ap3m1-antibody-ab113104.html
AP2M1 - PrimePCR Assay and Template | Life Science | Bio-Rad  AP2M1 - PrimePCR Assay and Template | Life Science | Bio-Rad
Adaptor-related protein complex 2, mu 1 subunit Assay Type: SYBR® Green Assay Design: Exonic Application: Gene Expression ... Adaptor-related protein complex 2, mu 1 subunit Assay Type: Probe Assay Design: Exonic Application: Gene Expression Unique ... The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/gene/ap2m1-pig
AP4M1 - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad  AP4M1 - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad
adaptor-related protein complex 4, mu 1 subunit. Aliases:. CPSQ3, MU-4, MU-ARP2. ... The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition ... This gene encodes a subunit of the heterotetrameric AP-4 complex. ... and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [ ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/dhsacpe5044039-primepcr-ddpcr-expression-probe-assay-ap4m1-human
Search Results  Search Results
adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.169770. 7.812. 2 Whole brain. AD-cases-controls. GSE5281 Human Brain ... adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.346075. 13.696. 1 Whole brain. AD-cases-controls. GSE5281 Human ... adaptor-related protein complex 1, mu 1 subunit. Chr19: 16.169697. 10.808. 3 Whole brain. AD-cases-controls-Myers. GSE15222 ... adaptor-related protein complex 1, mu 1 subunit; 3' UTR. Chr19: 16.207086. -0.780. ...
more infohttp://www.genenetwork.org/webqtl/WebQTL.py?cmd=sch&geneid=8907&species=human
ap2m1 Summary [species: Xenopus laevis and  Xenopus tropicalis] - Xenbase Gene Catalog
	  ap2m1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog
Gene Name: adaptor related protein complex 2 mu 1 subunit Synonyms: clapm1 Add Xenopus synonyms , Nomenclature history Gene ... NM_001087334,Xenopus laevis adaptor related protein complex 2 mu 1 subunit L homeolog (ap2m1.L), mRNA ... NM_203644,Xenopus tropicalis adaptor related protein complex 2 mu 1 subunit (ap2m1), mRNA ... Protein Refseq ,NP_988975,AP-2 complex subunit mu [Xenopus tropicalis] ...
more infohttp://www.xenbase.org/gene/showgene.do?method=display&geneId=6258426
anti-AP1M2 antibody  | GeneTex  anti-AP1M2 antibody | GeneTex
... adaptor related protein complex 1 mu 2 subunit) for IHC-P, WB. Anti-AP1M2 pAb (GTX33012) is tested in Human, Mouse samples. 100 ... adaptor related protein complex 1 mu 2 subunit. Background. This gene encodes a subunit of the heterotetrameric adaptor-related ... protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting ... Recombinant funsion protein containing a sequence corresponding to amino acids 164-423 of human AP1M2 (NP_005489.2).. ...
more infohttp://www.genetex.com/AP1M2-antibody-GTX33012.html
anti-AP4M1 antibody [N1C1]  | GeneTex  anti-AP4M1 antibody [N1C1] | GeneTex
... mu 1 subunit) for IHC-P, WB. Anti-AP4M1 pAb (GTX115196) is tested in Human, Mouse samples. 100% Ab-Assurance. ... adaptor-related protein complex AP-4 mu4 subunit antibody, mu subunit of AP-4 antibody, AP-4 complex subunit mu-1 antibody, mu- ... adapter-related protein complex 4 mu-1 subunit antibody, mu4-adaptin antibody, "adaptor-related protein complex 4, mu 1 subunit ... adaptor-related protein complex 4, mu 1 subunit. Background. This gene encodes a subunit of the heterotetrameric AP-4 complex. ...
more infohttp://www.genetex.com/AP4M1-antibody-N1C1-GTX115196.html
Subcellular forms and biochemical events triggered in human cells by HCV polyprotein expression from a viral vector | Virology...  Subcellular forms and biochemical events triggered in human cells by HCV polyprotein expression from a viral vector | Virology...
HCV proteins induced formation of large electron-dense cytoplasmic structures derived from the ER and containing HCV proteins. ... In the course of HCV protein production, there is disruption of the Golgi apparatus, loss of spatial organization of the ER, ... HCV proteins expressed from VT7-HCV7.9 localize largely in a globular-like distribution pattern in the cytoplasm, with some ... proteins co-localizing with the endoplasmic reticulum (ER) and mitochondria. As examined by electron microscopy, ...
more infohttps://virologyj.biomedcentral.com/articles/10.1186/1743-422X-5-102
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand...  The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand...
Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu ... Complex Polymorphisms in an ∼330 kDa Protein Are Linked to Chloroquine-Resistant P. falciparum in Southeast Asia and Africa. ...
more infohttps://www.semanticscholar.org/paper/The-pfmdr1-gene-is-associated-with-a-phenotype-in-Price-Cassar/530fa9b929bc540dc0834dc8c5c9ede83e219a40
AP3D1 - Wikipedia  AP3D1 - Wikipedia
"Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting ... AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene. AP3D1 is a subunit of the AP3 adaptor- ... "Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit". Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J ... "Characterization of the adaptor-related protein complex, AP-3". The Journal of Cell Biology. 137 (4): 835-45. doi:10.1083/jcb. ...
more infohttps://en.wikipedia.org/wiki/AP3D1
AP3M1 - Wikipedia  AP3M1 - Wikipedia
"Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... AP-3 complex subunit mu-1 is a protein that in humans is encoded by the AP3M1 gene. The protein encoded by this gene is the ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ... AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a ...
more infohttps://en.wikipedia.org/wiki/AP3M1
  • They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). (genecards.org)
  • Adaptins are distantly related to the other main type of vesicular transport proteins, the coatomer subunits, sharing between 16% and 26% of their amino acid sequence. (wikipedia.org)
  • Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules from one subcellular location to another. (wikipedia.org)
  • The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. (uniprot.org)
  • A 60kDa cytosolic protein, essential for protein import into the nucleus, and with a 44% sequence identity to SRP1p, was purified from Xenopus eggs. (wikipedia.org)
  • As determined by confocal microscopy, HCV proteins expressed from VT7-HCV7.9 localize largely in a globular-like distribution pattern in the cytoplasm, with some proteins co-localizing with the endoplasmic reticulum (ER) and mitochondria. (biomedcentral.com)
  • The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus, with the two importin proteins being recycled to the cytoplasm for further use. (wikipedia.org)
  • AIF1 is a protein that exists in the cytoplasm, and it is highly evolutionarily conserved. (wikipedia.org)
  • In this model, we observed that HCV proteins control cellular translation through eIF-2α-S51 phosphorylation, with involvement of the double-stranded RNA-dependent protein kinase PKR. (biomedcentral.com)
  • The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). (uniprot.org)
  • Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene. (wikipedia.org)
  • This protein is capable of interacting with tyrosine-based sorting signals. (nih.gov)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • The detailed sequence analysis of Doublecortin and Doublecortin-like proteins allowed the identification of a tandem repeat of evolutionarily conserved Doublecortin (DC) domains. (wikipedia.org)
  • In 1996, two groups independently described the complete sequence of the NEDD9 gene, and provided initial functional analysis of NEDD9 protein. (wikipedia.org)