Adaptor Protein Complex gamma Subunits
Adaptor Protein Complex 1
Adaptor Protein Complex 2
Adaptor Protein Complex 4
Adaptor Protein Complex Subunits
Adaptor Protein Complex delta Subunits
Adaptor Protein Complex mu Subunits
Adaptor Proteins, Vesicular Transport
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.
Adaptor Protein Complex beta Subunits
Adaptor Protein Complex alpha Subunits
Adaptor Proteins, Signal Transducing
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.
Early embryonic death of mice deficient in gamma-adaptin. (1/69)Intracellular protein transport and sorting by vesicles in the secretory and endocytic pathways requires the formation of a protein coat on the membrane. The heterotetrameric adaptor protein complex 1 (AP-1) promotes the formation of clathrin-coated vesicles at the trans-Golgi network. AP-1 interacts with various sorting signals in the cytoplasmic tails of cargo molecules, thus indicating a function in protein sorting. We generated mutants of the gamma-adaptin subunit of AP-1 in mice to investigate its role in post-Golgi vesicle transport and sorting processes. gamma-Adaptin-deficient embryos develop until day 3.5 post coitus and die during the prenidation period, revealing that AP-1 is essential for viability. In heterozygous mice the amount of AP-1 complexes is reduced to half of controls. Free beta1- or micro1 chains were not detectable, indicating that they are unstable unless they are part of AP-1 complexes. Heterozygous mice weigh less then their wild-type littermates and show impaired T cell development. (+info)
Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (2/69)We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1 and 3 positions of the 2-deoxystreptamine moiety of the antibiotics. These two amines appear to mimic the epsilon-amino groups present in the two lysine residues of the KKXX motif that is known to bind coatomer. Here we report the effects of 1, 3-cyclohexanebis(methylamine) (CBM) on secretion in vivo, a compound chosen for study because it contains primary amino groups that resemble those in 2-deoxystreptamine and it should penetrate lipid bilayers more readily than antibiotics. CBM inhibited coatomer binding to Golgi membranes in vitro and in vivo and inhibited secretion by intact cells. Despite depressed binding of coatomer in vivo, the Golgi complex retained its characteristic perinuclear location in the presence of CBM and did not fuse with the endoplasmic reticulum (ER). Transport from the ER to the Golgi was also not blocked by CBM. These data suggest that a full complement of coat protein I (COPI) on membranes is not critical for maintenance of Golgi integrity or for traffic from the ER to the Golgi but is necessary for transport through the Golgi to the plasma membrane. (+info)
Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. (3/69)Insulin stimulates adipose cells both to secrete proteins and to translocate the GLUT4 glucose transporter from an intracellular compartment to the plasma membrane. We demonstrate that whereas insulin stimulation of 3T3-L1 adipocytes has no effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipocyte complement related protein of 30 kD (ACRP30) is markedly enhanced. Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme. Thus, 3T3-L1 adipocytes possess a regulated secretory compartment containing ACRP30. Whether GLUT4 recycles to such a compartment has been controversial. We present deconvolution immunofluorescence microscopy data demonstrating that the subcellular distributions of ACRP30 and GLUT4 are distinct and nonoverlapping; in contrast, those of GLUT4 and the transferrin receptor overlap. Together with supporting evidence that GLUT4 does not recycle to a secretory compartment via the trans-Golgi network, we conclude that there are at least two compartments that undergo insulin-stimulated exocytosis in 3T3-L1 adipocytes: one for ACRP30 secretion and one for GLUT4 translocation. (+info)
Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. (4/69)The AP-1 adaptor complex is associated with the TGN, where it links selected membrane proteins to the clathrin lattice, enabling these proteins to be concentrated in clathrin-coated vesicles. To identify other proteins that participate in the clathrin-coated vesicle cycle at the TGN, we have carried out a yeast two- hybrid library screen using the gamma-adaptin subunit of the AP-1 complex as bait. Two novel, ubiquitously expressed proteins were found: p34, which interacts with both gamma-adaptin and alpha-adaptin, and gamma-synergin, an alternatively spliced protein with an apparent molecular mass of approximately 110-190 kD, which only interacts with gamma-adaptin. gamma-Synergin is associated with AP-1 both in the cytosol and on TGN membranes, and it is strongly enriched in clathrin-coated vesicles. It binds directly to the ear domain of gamma-adaptin and it contains an Eps15 homology (EH) domain, although the EH domain is not part of the gamma-adaptin binding site. In cells expressing alpha-adaptin with the gamma-adaptin ear, a construct that goes mainly to the plasma membrane, much of the gamma-synergin is also rerouted to the plasma membrane, indicating that it follows AP-1 onto membranes rather than leading it there. The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins. (+info)
Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains. (5/69)The molecular basis of the selectivity and the details of the vesicle formation in endocytic and secretory pathways are still poorly known and most probably involve as yet unidentified components. Here we describe the cloning, expression, and tissue and cell distribution of a novel protein of 67 kDa (called Vear) that bears homology to several endocytosis-associated proteins in that it has a VHS domain in its N terminus. It is also similar to gamma-adaptin, the heavy subunit of AP-1, in having in its C terminus a typical "ear" domain. In immunofluorescence microscopy, Vear was seen in the Golgi complex as judged by a typical distribution pattern, a distinct colocalization with the Golgi marker gamma-adaptin, and a sensitivity to treatment of cells with brefeldin A. In cell fractionation, Vear partitioned with the post-nuclear membrane fraction. In transfection experiments, hemagglutinin-tagged full-length Vear and truncated Vear lacking the VHS domain assembled on and caused compaction of the Golgi complex. Golgi association without compaction was seen with the ear domain of Vear, whereas the VHS domain alone showed a diffuse membrane- and vesicle-associated distribution. The Golgi association and the bipartite structure along with the differential targeting of its domains suggest that Vear is involved in heterotypic vesicle/suborganelle interactions associated with the Golgi complex. Tissue-specific function of Vear is suggested by its high level of expression in kidney, muscle, and heart. (+info)
A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. (6/69)We have cloned and characterized members of a novel family of proteins, the GGAs. These proteins contain an NH(2)-terminal VHS domain, one or two coiled-coil domains, and a COOH-terminal domain homologous to the COOH-terminal "ear" domain of gamma-adaptin. However, unlike gamma-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes. Immunogold EM shows that these membranes correspond to trans elements of the Golgi stack and the TGN. GST pulldown experiments indicate that the GGA COOH-terminal domains bind to a subset of the proteins that bind to the gamma-adaptin COOH-terminal domain. In yeast there are two GGA genes. Deleting both of these genes results in missorting of the vacuolar enzyme carboxypeptidase Y, and the cells also have a defective vacuolar morphology phenotype. These results indicate that the function of the GGAs is to facilitate the trafficking of proteins between the TGN and the vacuole, or its mammalian equivalent, the lysosome. (+info)
GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. (7/69)Formation of intracellular transport intermediates and selection of cargo molecules are mediated by protein coats associated with the cytosolic face of membranes. Here, we describe a novel family of ubiquitous coat proteins termed GGAs, which includes three members in humans and two in yeast. GGAs have a modular structure consisting of a VHS domain, a region of homology termed GAT, a linker segment, and a region with homology to the ear domain of gamma-adaptins. Immunofluorescence microscopy showed colocalization of GGAs with Golgi markers, whereas immunoelectron microscopy of GGA3 revealed its presence on coated vesicles and buds in the area of the TGN. Treatment with brefeldin A or overexpression of dominant-negative ADP ribosylation factor 1 (ARF1) caused dissociation of GGAs from membranes. The GAT region of GGA3 was found to: target a reporter protein to the Golgi complex; induce dissociation from membranes of ARF-regulated coats such as AP-1, AP-3, AP-4, and COPI upon overexpression; and interact with activated ARF1. Disruption of both GGA genes in yeast resulted in impaired trafficking of carboxypeptidase Y to the vacuole. These observations suggest that GGAs are components of ARF-regulated coats that mediate protein trafficking at the TGN. (+info)
Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells. (8/69)Expression of the epithelial cell-specific heterotetrameric adaptor complex AP-1B is required for the polarized distribution of many membrane proteins to the basolateral surface of LLC-PK1 kidney cells. AP-1B is distinguished from the ubiquitously expressed AP-1A by exchange of its single 50-kD mu subunit, mu1A, being replaced by the closely related mu1B. Here we show that this substitution is sufficient to couple basolateral plasma membrane proteins, such as a low-density lipoprotein receptor (LDLR), to the AP-1B complex and to clathrin. The interaction between LDLR and AP-1B is likely to occur in the trans-Golgi network (TGN), as was suggested by the localization of functional, epitope-tagged mu1 by immunofluorescence and immunoelectron microscopy. Tagged AP-1A and AP-1B complexes were found in the perinuclear region close to the Golgi complex and recycling endosomes, often in clathrin-coated buds and vesicles. Yet, AP-1A and AP-1B localized to different subdomains of the TGN, with only AP-1A colocalizing with furin, a membrane protein that uses AP-1 to recycle between the TGN and endosomes. We conclude that AP-1B functions by interacting with its cargo molecules and clathrin in the TGN, where it acts to sort basolateral proteins from proteins destined for the apical surface and from those selected by AP-1A for transport to endosomes and lysosomes. (+info)
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ... and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ...
Sec61 alpha 1
... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... contains beta and gamma subunits. GRCh38: Ensembl release 89: ENSG00000058262 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located ... Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. ...
Clathrin adaptor protein
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Gamma-adaptin ear homology, ARF-binding proteins) adaptors. Adaptins are distantly related to the other main type of vesicular ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ...
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
Vesicular transport adaptor protein
The other large protein has different designations in the different complexes. In AP-1 it is named γ (gamma), AP-2 has α (alpha ... The two smaller proteins are a medium subunit named μ (mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ...
... the plasma membrane the TCR receptor chains α and β associate with six additional adaptor proteins to form an octameric complex ... The intersection of these specific regions (V and J for the alpha or gamma chain; V, D, and J for the beta or delta chain) ... in the transmembrane domain of each subunit form polar interactions allowing a correct and stable assembly of the complex. The ... LAT associates with another scaffolding protein Slp-76 via the Grap2 adaptor protein, which provides additional binding sites. ...
... encoding protein Serine incorporator 3 SHLD1: encoding protein Shieldin complex subunit 1 SLC17A9: encoding protein Solute ... encoding protein cAMP-dependent protein kinase inhibitor gamma PLAGL2: encoding protein Zinc finger protein PLAGL2 POLR3F: ... encoding protein Kizuna centrosomal protein Kua-UEV: LIME1: encoding protein Lck-interacting transmembrane adapter 1 LZTS3: ... encoding protein Zinc finger protein 334 ZNF343: encoding protein Zinc finger protein 343 ZSWIM3: encoding protein Zinc finger ...
Beta2-adaptin C-terminal domain
Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors. AP (adaptor protein) complexes are found in coated vesicles ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ...
IFN-γ suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, ... sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex ... including subunits of the immunoproteasome (MECL1, LMP2, LMP7), as well as TAP and ERAAP in addition possibly to the direct ... September 1995). "Interaction between the components of the interferon gamma receptor complex". The Journal of Biological ...
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ...
... domain that is contained in the adaptor protein families Crk, Grb2, and Nck. These adaptor proteins then couple to enzymes to ... An activated complex of GAB2, SHC, and SHP2 is required for binding of Phospholipase C gamma 2 (PLCG2) through its SH2 domain, ... The p85 subunit of PI3K (or PIK3) possessed the SH2 domain required to be activated by GAB2. The activation of the PI3K ... GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking ...
2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an ... "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299- ... CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a ... T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@. It contributes ...
List of A1 genes, proteins or receptors
... alpha 1 Adaptor-related protein complex 2, alpha 1 Aldehyde dehydrogenase 3 family, member A1 Aldehyde dehydrogenase 4 family, ... subunit, alpha 1 Protein kinase, AMP-activated, alpha 1 Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), ... member A1 Gamma-aminobutyric acid (GABA) A receptor, alpha 1 Gap junction protein, alpha 1 GDNF family receptor alpha 1 ... alpha 1 RNA binding motif protein, Y-linked, family 1, member A1 Replication protein A1 S100 calcium binding protein A1 Sec61 ...
"Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits ... including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765-71. doi: ...
Lymphocyte cytosolic protein 2
SLP-76, LAT, and Gads together combine into protein complexes, typically with LAT at the center and SLP-76 proteins on the ... As an adaptor protein, SLP-76 does not have catalytic functions, primarily binding other signaling proteins to form larger ... July 1996). "Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking". Blood. 88 ... with the p85 subunit of phosphoinositide 3-kinase". FEBS Letters. 575 (1-3): 35-40. doi:10.1016/j.febslet.2004.07.090. PMID ...
"SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and ... "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (March 1994). "A complex of Grb2 adaptor protein, Sos exchange ...
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. The Fc-gamma receptors differ ... Chauhan AK, Moore TL (2012). "Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human ... Chauhan AK, Moore TL (2011). "T cell activation by terminal complex of complement and immune complexes". The Journal of ...
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. Adaptor protein complex 1 is found at the ... Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in ... "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; ... The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein ...
... as an adaptor or scaffolding protein by permitting the recruitment of the inhibitor of nuclear factor-kappa-B kinase subunit ... The link between these two protein within the JAK1-SNX8 complex allows JAK1 to catalyse SNX8's tyrosines phosphorylation in ... SNX8 is a component of an IKKβ-mediated noncanonical signaling pathway triggered by the interferon gamma, which takes places ... are involved in protein-protein interactions. The SNX8 protein, even though is very similar to the other sorting nexins, ...
"Entrez Gene: COPG2 coatomer protein complex, subunit gamma 2". Bermak JC, Li M, Bullock C, Weingarten P, Zhou QY (Feb 2002). " ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... Coatomer subunit gamma-2 is a protein that in humans is encoded by the COPG2 gene. COPG2 has been shown to interact with ...
The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated. GRCh38 ... 2002). "Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells". ... 1996). "Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI ... Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for ...
"Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit". Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH ... Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma ... AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene. AP2A2 has been shown to interact with ... the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes ...
1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in ... This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. Model organisms have been ... 5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene. The protein encoded ... 1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". J. Biol. Chem. 271 (15): 8675- ...
G beta-gamma complex
The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a ... "The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101". Cell. 89 (1): 105-14. doi:10.1016 ... One of the major functions of Gβγ is the inhibition of the Gα subunit. The individual subunits of the G protein complex were ... G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex ...
Prostaglandin DP2 receptor
Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ... clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2 unable to mobilize ... activated DP2 triggers Gi alpha subunit-linked heterotrimeric G proteins to dissociate into their component a) ...
The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor- ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2 ... to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry ...
The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay ... Jefferies C, Bowie A, Brady G, Cooke EL, Li X, O'Neill LA (July 2001). "Transactivation by the p65 subunit of NF-kappaB in ... March 2002). "Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response ... "Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in ...
Adapter molecule crk
"Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. ... Riordan SM, Lidder S, Williams R, Skouteris GG (2000). "The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF ... 1990). "Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors". Science. 250 ( ... Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This ...
... may interact directly with APC subunit APC10 and thus recruit the APC complex. CDH1 subunit of the APC complex recognizes NEDD9 ... "Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease" (Oncoscience ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ...
The DAP3 gene encodes a 46 kDa protein located in the lower area of the small mitoribosomal subunit. This protein contains a P- ... Miyazaki T, Reed JC (Jun 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nature ... As part of the mitoribosome, DAP3 participates in the translation of the 13 ETC complex proteins encoded in the mitochondrial ... and gamma interferon. Additionally, DAP3 interacts with the factor IPS-1 to activate caspases 3, 8, and 9, resulting in a type ...
Alfred G. Gilman
Tang, WJ; Gilman, AG (1991). "Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits". Science. 254 ( ... His first research project was to test the adaptor hypothesis of Francis Crick. He worked in the laboratory of Melvin Simpson, ... "Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS". Science. 278 (5345): 1907- ... "Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel". Nature. 368 (6468): 255-7. ...
The binding of lipophilic protein complex to the host membrane facilitates the interaction of this three protein complex with ... and the large protein (L) that is a catalytic subunit of this polymerase. C-protein, which is translated from an alternative ... Interferon gamma (IFN-gamma) also strongly promotes the MHC II-dependent presentation of antigens. Higher MHC I expression ... Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN (April 2013). "The adaptor MAVS promotes NLRP3 mitochondrial ...
In response to IFN, this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9) and form ISGF-3 ... Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be ... March 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 ... June 2000). "Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains". Science. ...
... reveals a protein with properties of a transcriptional adaptor". Genes Dev. 8 (8): 869-84. doi:10.1101/gad.8.8.869. PMID ... "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and ... "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. ... Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 ...
... proteins interact with adaptor proteins that facilitate signaling protein interactions and coordination of signaling complexes ... The activated G protein subunits detach from the receptor and initiate signaling from many downstream effector proteins such as ... The three-dimensional structure at 6 A resolution of a human gamma G1 immunoglobulin molecule, J Biol. Chem. 246 (11) 3752- 9 ... Enzymes and adaptor proteins are both responsive to various second messenger molecules. Many adaptor proteins and enzymes ...
For instance, 14-3-3ζ controls cellular senescence by complexing with BIS to chaperone protein folding of STAT3 and activate ... "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". The ... "Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta". Blood. 91 (4): 1295- ... The antigenic 14-3-3ζ can directly affect T cell differentiation into Th1 and Th17 cells, and thereby promotes IFN-gamma and IL ...
The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are ... Furge KA, Zhang YW, Vande Woude GF (November 2000). "Met receptor tyrosine kinase: enhanced signaling through adapter proteins ... Since HGF is the only known ligand of MET, blocking the formation of a HGF:MET complex blocks MET biological activity. For this ... "Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis". Oncogene. 19 (12 ...
... the pyrin domain of the adaptor protein ASC has recently been shown to function as a prion-like domain, through a self- ... Caspase-1 then assembles into its active form consisting of two heterodimers with a p20 and p10 subunit each. Once active, it ... ASC helps recruit caspase-1 to associate with NLRs in the inflammasome complex via its CARD domain. ASC also has duties ... January 1997). "Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme". Science. 275 ( ...
"Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cell. ...
... and is stimulated by the G protein beta and gamma subunit complex. Therefore, ADCY2 is highly regulated by G-proteins, calcium ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library ... An essential cofactor for ADCY2 is magnesium; two ions bind per subunit. Structurally, ADCY2 are transmembrane proteins with ... The protein is organized with six transmembrane segments followed by the C1 cytoplasmic domain. Then another six membrane ...
Naive T cell
... associated protein Zap70 activated Zap70 in turn phosphorylates the membrane adaptor Lat, which subsequently recruits several ... the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes". J. Immunol. ... In the naive state, T cells are thought to require the common-gamma chain cytokines IL-7 and IL-15 for homeostatic survival ... They also express functional IL-7 receptors, consisting of subunits IL-7 receptor-α, CD127, and common-γ chain, CD132. ...
The adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits - PubMed
... is a heterotetrameric complex composed of ε, β4, μ4, and σ4 subunits that mediates export of a subset of transmembrane cargos, ... including autophagy protein 9A (ATG9A), from the ,i,trans,/i,-Golgi network (TGN). AP-4 has received particular attention in ... and gamma-adaptin-binding protein (AAGAB, also known as p34) binds to and stabilizes the AP-4 ε and σ4 subunits, thus promoting ... The adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits Rafael Mattera 1 , Raffaella De Pace 1 , Juan S Bonifacino ...
Adaptor Protein Complex gamma Subunits [D12.776.543.990.150.500.400] * Adaptor Protein Complex mu Subunits [D12.776.543.990. ... They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.. Terms. Adaptor Protein Complex gamma Subunits ... 2003; GAMMA-ADAPTIN (now ADAPTOR PROTEIN COMPLEX GAMMA SUBUNITS) was indexed under MEMBRANE PROTEINS 1995-2002, PROTEINS 1991- ... Adaptor Protein Complex alpha Subunits [D12.776.543.990.150.500.100] * Adaptor Protein Complex beta Subunits [D12.776.543.990. ...
Research - Juan Bonifacino Lab | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Our laboratory investigates the molecular mechanisms by which transmembrane proteins (referred to as ... mu2 and mu3 subunits of three hetero-tetrameric adaptor protein (AP) complexes, AP-1, AP-2 and AP-3, respectively. Dileucine- ... gamma-sigma1, alpha-sigma2 and delta-sigma3, of the corresponding AP-1, AP-2 and AP-3 complexes. We subsequently found that a ... of sorting signals in the cytosolic tails of transmembrane proteins by adaptor proteins that are components of protein coats ( ...
2003; GAMMA-ADAPTIN (now ADAPTOR PROTEIN COMPLEX GAMMA SUBUNITS) was indexed under MEMBRANE PROTEINS 1995-2002, PROTEINS 1991- ... Adaptor Protein Complex gamma Subunits - Preferred Concept UI. M0183696. Scope note. A family of large adaptin protein subunits ... Adaptor Protein Complex gamma Subunits Descriptor Spanish: Subunidades gamma de Complejo de Proteína Adaptadora Spanish from ... Sous-unités gamma du complexe protéique adaptateur Entry term(s):. Clathrin Assembly Protein Complex gamma Subunits. gamma ...
Adaptor Protein Complex gamma Subunits [D12.776.543.990.150.500.400] * Adaptor Protein Complex mu Subunits [D12.776.543.990. ... They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.. Terms. Adaptor Protein Complex gamma Subunits ... 2003; GAMMA-ADAPTIN (now ADAPTOR PROTEIN COMPLEX GAMMA SUBUNITS) was indexed under MEMBRANE PROTEINS 1995-2002, PROTEINS 1991- ... Adaptor Protein Complex alpha Subunits [D12.776.543.990.150.500.100] * Adaptor Protein Complex beta Subunits [D12.776.543.990. ...
NDF-RT Code NDF-RT Name
Adaptor Protein Complex delta Subunits N0000168706 Adaptor Protein Complex gamma Subunits N0000168707 Adaptor Protein Complex ... Adaptor Protein Complex 4 N0000168709 Adaptor Protein Complex alpha Subunits N0000168708 Adaptor Protein Complex beta Subunits ... mu Subunits N0000168705 Adaptor Protein Complex sigma Subunits N0000168703 Adaptor Protein Complex Subunits N0000170426 Adaptor ... adapalene N0000168700 Adaptor Protein Complex 1 N0000168711 Adaptor Protein Complex 2 N0000168710 Adaptor Protein Complex 3 ...
Pharos : Target Details - AP1G2
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, ... protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi ... The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- ...
Pesquisa | Portal Regional da BVS
... encoding gamma-1 subunit of adaptor-related protein complex 1 (AP1Î³1), associated with a neurodevelopmental disorder (NDD) ... Adaptor protein (AP) complexes mediate selective intracellular vesicular trafficking and polarized localization of ... Missense variant protein expression and BAF subunit interactions were examined using 3D protein modeling, co- ... somatodendritic proteins in neurons. Disease-causing alleles of various subunits of AP complexes have been implicated in ...
A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ... between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein ... Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.. Goldstein BJ; Bittner-Kowalczyk A; ... 9. Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine- ...
NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008
HN - 2008 BX - Protein Kinase A, Catalytic Subunits MH - Cyclic AMP-Dependent Protein Kinase RIalpha Subunit UI - D054756 MN - ... The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the ... A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A ... In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme. HN ...
The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer's disease
AP2 Adaptor Complex Subunit mu. gamma Aminobutyric Acid Type A Receptor Subunit beta 3 (GABRB3) ... beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) ... Glutamate Ionotropic Receptor NMDA Type Subunit 1 (GRIN1/NR1). Glutamate Ionotropic Receptor NMDA Type Subunit 2A (GluN2A/NR2A) ... AP2 Adaptor Complex Subunit beta/beta Adaptin. ... AP2 Adaptor Complex Subunit alpha/alpha Adaptin. ...
GSE9006 HEALTHY VS TYPE 2 DIABETES PBMC AT DX DN
adaptor related protein complex 3 subu.... ARPC2. 10109. ARPC2. actin related protein 2/3 complex subu.... ... protein O-glucosyltransferase 1 [Sourc.... POLR2B. 5431. POLR2B. RNA polymerase II subunit B [Source:HG.... ... alpha hemoglobin stabilizing protein [.... AIM1. 202. CRYBG1. crystallin beta-gamma domain containin.... ...
Human Genome Epidemiology Literature Finder|Home|PHGKB
NEW (2010) MESH HEADINGS WITH SCOPE NOTES (UNIT RECORD FORMAT; 8/31/2009
COMPLEX, TR-ASSOCIATED PROTEIN (TRAP) COMPLEX and THYROID HORMONE-ASSOCIATED PROTEIN COMPLEX use MEDIATOR COMPLEX SUBUNIT 1 ... A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and ... It is caused by mutations in EPITHELIAL SODIUM CHANNEL beta and gamma subunits. Different mutations in the same EPITHELIAL ... The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in ...
Gastrointestinal inflammation - Ontology Report - Rat Genome Database
actin related protein 2/3 complex subunit 1B. IAGP. HPO. NCBI chr 7:99,374,259...99,394,816 Ensembl chr 7:99,374,249... ... laminin subunit gamma 2. IAGP. HPO. NCBI chr 1:183,186,264...183,258,968 Ensembl chr 1:183,186,238...183,245,127 ... BCL10 immune signaling adaptor. IAGP. HPO. NCBI chr 1:85,265,776...85,276,632 Ensembl chr 1:85,265,776...85,276,632 ... actin related protein 2/3 complex subunit 1B. IAGP. HPO. NCBI chr 7:99,374,259...99,394,816 Ensembl chr 7:99,374,249... ...
Signal transduction - IP3 signaling Pathway Map - PrimePCR | Life Science | Bio-Rad
PLC-beta is activated by G-proteins, such as G-proteins alpha-q/11 and G-proteins beta/gamma, which, in turn, are activated by ... Ca(II)/calmodulin complex binds to and stimulates Ca(II)/calmodulin-dependent protein kinases CaMKK, CaMKII and CaMKIV. CaMKIV ... transduces signals to the protein kinase ZAP70, which further phosphorylates transmembrane adaptor LAT . LAT activates PLC- ... while CD79A/CD79B subunits transduce signals to the cell interior. BCR activates protein tyrosine kinase Syk, which, in turn, ...
Download Data Mining And Predictive Analysis Intelligence Gathering And Crime Analysis 2015
... a complex of the available COPII adaptor( Miller et al, 2002; Miller et al, 2003; Mossessova et al, 2003; Mancias and Goldberg ... N-glycosylation is few acts in brain subtype and consequence or open subunit of P2 polymers. reaction Membrane proteins in the ... NGF is gamma-aminobutyric membrane of cathepsin, a Vitamin of the MAPK membrane( Morooka synthetase, Nishida E, 1998). Both ... 1970, Membrane subunit tryptophan from Streptococcus diseases. protein and snRNA, J. 1970, Membrane health susceptibility from ...
Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE | Nature Communications
Changes in protein subcellular localization can be determined using mass spectrometry. Here, the authors present a statistical ... Differential localisation, that is a change in the steady-state subcellular location of a protein, provides a step towards ... Here, we describe a principled Bayesian approach, BANDLE, that uses these data to compute the probability that a protein ... These localisations are context specific with proteins translocating between different subcellular niches upon perturbation of ...
Adaptor Protein Complex beta Subunits Adaptor Protein Complex delta Subunits Adaptor Protein Complex gamma Subunits Adaptor ... Adaptor Protein Complex 1 Adaptor Protein Complex 2 Adaptor Protein Complex 3 Adaptor Protein Complex 4 Adaptor Protein Complex ... Protein Complex mu Subunits Adaptor Protein Complex sigma Subunits Adaptor Protein Complex Subunits Adaptor Proteins, Signal ... ADAMTS Proteins ADAMTS1 Protein ADAMTS13 Protein ADAMTS4 Protein ADAMTS5 Protein ADAMTS7 Protein ADAMTS9 Protein Adansonia ...
The Multifaceted Mitochondria: Unexpected role of Mitochondria in Diseases | Madridge Publishers
A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008; 134(1): 112-123. doi: 10.1016/j.cell. ... and their movement is sensitive to disruption of these motors and adaptor proteins . Therefore, mitochondrial movement has ... In Neurospora crassa mitochondria takes part in the synthesis of one subunit of the succinic dehydrogenate enzyme . ... A nuclear gene, called DNA polymerase gamma (POLG), encodes the DNA polymerase responsible for replicating the mitochondrial ...
IJMS | Free Full-Text | Recent Developments in Peptide-Based Nucleic Acid Delivery
... ligands cluster into clathrin-coated pits by association with clathrin adaptor proteins such as the four-subunit complex AP2. ... The sweet arrow peptide (SAP) is derived from the proline-rich N-terminal repetitive domain of gamma-zein, a storage protein of ... Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis- ... Ku70, a protein that plays an important role in DNA repair, was found to bind Bcl-2-associated X protein (Bax), a member of the ...
P-MAPA immunotherapy potentiates the effect of cisplatin on serous ovarian carcinoma through targeting TLR4 signaling | Journal...
The combination therapy also promoted the increase in the levels of the following OC-related proteins: TLR4, MyD88, TRIF, ... we investigated the effect of a promising immunotherapeutic strategy based on protein aggregate magnesium-ammonium ... are transmembrane proteins expressed on the surface of ovarian cancer (OC) and immune cells. Identifying the specific roles of ... inhibitor of NF-kB kinase subunit alpha; p-IkBα: inhibitor of phosphorylated NF-kB subunit alpha; NF-kB p65: NF-kB subunit p65 ...
Awardees and Abstracts | AAFRP
LAT-based complexes in vitro for the purpose of visualizing specific protein-protein interfaces by X-ray crystallography. These ... The transmembrane adapter protein LAT is essential for FceRI-mediated signaling in mast cells and for T cell activation ... NF-kB is composed of either heterodimeric subunits (e.g. p50-p65 heterodimers) or homodimeric subunits (e.g. p50 homodimers). ... We hypothesize that the cell-selective nuclear import of the smooth muscle gamma actin (SMGA) promoter is mediated by the ...
What's hot today: Current papers in developmental biology and gene function
... irrespective of complex. One intriguing mutation in a complex IV subunit (cyclope) shows a suppressor rescue effect at early ... This effect depends on LpRs and Dab, the Drosophila ortholog of the Reelin signaling adaptor protein Dab1. In vitro, two of the ... Transgenerational effects of gamma radiation dose and dose rate on Drosophila flies irradiated at an early embryonal stage. ... The COPII subunit, Sec31, and ER exit site protein, Sec16, are critical for subcellular tube architecture, whereas the SNARE ...
Nucleated Red Blood Cells Contribute to the Host Immune Response Against Pathogens | IntechOpen
... adaptor-related protein complex 1 beta 1 subunit (AP1B1), adaptor-related protein complex 2 alpha 1 subunit (AP2A1), adaptor- ... Interferon gamma (IFNγ), a highly pleiotropic pro-inflammatory and antiviral cytokine exclusively produced in immune-related ... related protein complex 2 alpha 2 subunit (AP2A2), ADP ribosylation factor 1 (ARF1), calnexin (CANX), capping actin protein of ... An overview of protein-protein interaction network of a set of proteins, identified in rainbow trout proteome profiling, ...
Louis M. Staudt, M.D., Ph.D. | Principal Investigators | NIH Intramural Research Program
... which uses LUBAC to attach linear ubiquitin chains to the IkB kinase gamma subunit, thereby stimulating its enzymatic activity ... A parallel and cooperating oncogenic pathway in ABC DLBCL centers around MYD88, the key signaling adapter in the Toll receptor ... 8. Y. Yang et al., Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline ... While multiple myeloma cells require a basal level of autophagy to manage their persistent load of unfolded proteins, caspase- ...
Growth Factor Signaling
protein kinase cAMP-activated catalytic subunit beta P68181. Prkag1. protein kinase AMP-activated non-catalytic subunit gamma 1 ... regulatory associated protein of MTOR complex 1 Q8K4Q0. Sh2b2. SH2B adaptor protein 2 Q9JID9. ... protein kinase AMP-activated non-catalytic subunit gamma 2 Q91WG5. Prkag3. protein kinase AMP-activated non-catalytic subunit ... protein kinase type II subunit delta Q6PHZ2. Camk2g. calcium/calmodulin-dependent protein kinase type II subunit gamma. Q923T9 ...
Download The American Psychiatric Publishing Textbook Of Psychopharmacology 2009
2003) and contains the inhibitory download The American in the protein of HIF-alpha cargo by complex( Berra et al. HIF-alpha ... complex pathway M2 absence stablizes IL7 strand gene. Sahl SJ, Leutenegger M, Hilbert M, other SW, Eggeling C. Fast cyclin- ... Sampaio JL, Gerl MJ, Klose C, Ejsing CS, Beug H, Simons K, Shevchenko A. Membrane adaptor of an mature AREs maintenance. ... remaining its protein by a tyrosine in 2007, the sensitivity of Greensburg, Kansas( United States) primed to be to ...
Heterotetrameric complexUbiquitin-proteiAnaphase promotiKinaseGenesReceptorAdaptinTransmembrane proteinsMutationsCD79BBindsKinasesCellularAdenosineCalmodulin dependent proteinNucleic acidsStimulatesMediatesResiduesMicrotubulePhosphorylationInteractionsTranscription factorsTyrosineActinRegulatoryStimulateBindExtracellularEnzymesMitochondrialMolecularDegradationFindings demonstrateLysineAbundantMetabolismSequencesInteractionVitroHydrolysisMembrane-boundInhibitorSubcellularTranscriptionalTrans -GolgiFunctionOuterDemonstrateMAPKNrf2RegulatesRoleNuclearFamilyAggregateDrosophilaMechanismsBetaPathwaysStructural integrityCell
- Adaptor protein 4 (AP-4) is a heterotetrameric complex composed of ε, β4, μ4, and σ4 subunits that mediates export of a subset of transmembrane cargos, including autophagy protein 9A (ATG9A), from the trans -Golgi network (TGN). (nih.gov)
- Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. (nih.gov)
- Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
- The majority of early onset forms of Parkinson disease are a result of autosomal mutations in PRKN (parkin RBR E3 ubiquitin protein ligase) and PINK1 (PTEN induced kinase 1), which together regulate the clearance of damaged mitochondria from cells through selective autophagy of mitochondria (mitophagy). (biomed.news)
- Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. (duke.edu)
- 3. A 60-kilodalton protein in rat hepatoma cells overexpressing insulin receptor was tyrosine phosphorylated and associated with Syp, phophatidylinositol 3-kinase, and Grb2 in an insulin-dependent manner. (nih.gov)
- 8. Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation. (nih.gov)
- 9. Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1. (nih.gov)
- 16. T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. (nih.gov)
- BCR activates protein tyrosine kinase Syk , which, in turn, phosphorylates phospholipase PLC-gamma [ 3 ]. (bio-rad.com)
- T cell receptor ( TCR-CD3 complex ) transduces signals to the protein kinase ZAP70 , which further phosphorylates transmembrane adaptor LAT [ 6 ]. (bio-rad.com)
- DAG activates several isoforms of Protein kinase C ( PKC ), which stimulate v-raf-1 murine leukemia viral oncogene homolog 1 ( c-RAF-1 ) [ 12 ] and initiate Mitogen-activated protein kinase kinases 1 and 2 ( MEK1 and MEK2 )/ Mitogen-activated protein kinases 3 and 1 ( ERK1 and ERK2 ) cascade that, in turn, activates several transcription factors including ELK1 . (bio-rad.com)
- Further investigation revealed that IRF4 promotes constitutive NF-kB signaling in ABC DLBCL by transactivating CARD11, encoding a signaling adapter upstream of IkB kinase. (nih.gov)
- The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. (biomed.news)
- The mechanistic Target of Rapamycin (mTOR) is a growth-related kinase that, in the context of the mTOR complex 1 (mTORC1), touches upon most fundamental cellular processes. (biomed.news)
- For instance, ROS can stimulate the phosphorylation of protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK)1/2, phosphoinositide 3-kinase/serine-threonine kinase (PI3K/Akt), protein kinase B (PKB), and JUN N-terminal kinase (JNK) [ 4 - 6 ]. (hindawi.com)
- Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. (duke.edu)
- The physiological importance of these interactions is underscored by the observation that AAGAB-knockout cells exhibit reduced levels of AP-4 subunits and accumulation of ATG9A at the TGN like those in cells with mutations in AP-4-subunit genes. (nih.gov)
- Inactivating mutations in AP-4 subunit genes result in ATG9A accumulation in the TGN (Fig. 2), with consequent autophagic defects. (nih.gov)
- ROS are also involved in the increased expression of antioxidant genes related to the activation of transcription factors such as the nuclear factor erythroid 2-related factor 2 (Nrf2), activator protein 1 (AP-1), nuclear factor κ B (NF- κ B), hypoxia-inducible transcription factor 1a (HIF-1a), and p53 [ 7 - 9 ]. (hindawi.com)
- The genes were identified from this enormous amount of data using complex prediction models and then they were numbered for easy identification. (wordpress.com)
- Recent studies have identified new NRF2 target genes and revealed several new functions of NRF2 that go beyond its redox-regulating capacities, including regulation of inflammation, autophagy, metabolism, proteostasis, and unfolded protein response (UPR), particularly in the context of carcinogenesis. (encyclopedia.pub)
- In 2004, Dr. Li was selected as co-chair of the Pathways to Discovery program, which supports research to advance our understanding of how the building blocks of the body - genes, proteins, metabolites - function and interact via complex systems to maintain health and respond to disease. (nih.gov)
- Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. (nih.gov)
- 1. A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment. (nih.gov)
- 2. Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. (nih.gov)
- 5. Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. (nih.gov)
- 11. Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes. (nih.gov)
- 12. Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. (nih.gov)
- 17. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling. (nih.gov)
- IP3 signaling is initiated by its binding to cognate receptors, such as B-cell antigen receptor ( BCR ) in B-cells, TCR/CD3 complex in T-cells, PDGFR in mesenchymal cells, and GPCRs. (bio-rad.com)
- The downstream signaling cascades involve several isoforms of phospholipases ( PLC-beta , PLC-gamma , PLC-epsilon ) which catalyze hydrolysis of PI(4,5)P2 (phosphatidylinositol-4,5-biphosphate) into IP3 and DAG , Upon its release to cytoplasm, IP3 binds to IP3R (IP3 Receptor) on the surface of Endoplasmic Reticulum and mobilizes Ca(II) from internal stores [ 1 ]. (bio-rad.com)
- B-cell antigen receptor (BCR) is the multiprotein complex composed of Membrane Immunoglobulin molecules and associated Ig-Alpha( CD79A )/Ig-Beta(CD79B) heterodimer [ 2 ]. (bio-rad.com)
- The Membrane Immunoglobulin subunits bind antigens and cause receptor aggregation, while CD79A /CD79B subunits transduce signals to the cell interior. (bio-rad.com)
- Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. (nih.gov)
- 15)Cross-Linking of a DOPA-Containing Peptide Ligand into its G Protein-Coupled Receptor. (edu.in)
- 16)New topics in vasopressin receptors and approach to novel drugs:effects of vasopressin receptor on regulations of hormone secretion and metabolisms of glucose, fat, and protein. (edu.in)
- The rod outer segment (ROS) consists of tightly stacked membranous discs wherein the light-sensitive G-protein coupled receptor, rhodopsin, is embedded in high density [ 5 ]. (biomedcentral.com)
- lt;p>The present invention is directed to a strategy to discover small peptides that will activate any G protein coupled receptor (GPCR) or inactivate any constitutively active GPCR. (nih.gov)
- The method of the subject invention comprises expressing a peptide of a peptide library tethered to a G protein coupled receptor of interest in a cell, and monitoring the cell to determine whether the peptide is an agonist or negative antagonist of the GPCR of interest. (nih.gov)
- Here, we report that the alpha- and gamma-adaptin-binding protein (AAGAB, also known as p34) binds to and stabilizes the AP-4 ε and σ4 subunits, thus promoting complex assembly. (nih.gov)
- A family of large adaptin protein subunits of approximately 90 KDa in size. (nih.gov)
- The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. (nih.gov)
- The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. (nih.gov)
- Our laboratory investigates the molecular mechanisms by which transmembrane proteins (referred to as "cargo") are sorted to different compartments of the endomembrane system in eukaryotic cells. (nih.gov)
- A major focus of research in our laboratory is on processes mediated by recognition of sorting signals in the cytosolic tails of transmembrane proteins by adaptor proteins that are components of protein coats (Fig. 1). (nih.gov)
- Toll-like receptors (TLRs) are transmembrane proteins expressed on the surface of ovarian cancer (OC) and immune cells. (biomedcentral.com)
- AP-4 has received particular attention in recent years because mutations in any of its subunits cause a complicated form of hereditary spastic paraplegia referred to as "AP-4-deficiency syndrome. (nih.gov)
- This syndrome is one of many diseases, known as "coatopathies", which are caused by mutations in components of protein coats (Dell'Angelica and Bonifacino. (nih.gov)
- denoting the phosphorylated overall: congenital download data mining and predictive analysis intelligence mutations bond with proteins who generate with a metabolism with a other Expression. (evakoch.com)
- Mutations in KRIT1, a protein initially identified based on a yeast two-hybrid interaction with the RAS-family GTPase RAP1A, are responsible for the development of the inherited vascular disorder cerebral cavernous malformations (CCM1). (nih.gov)
- In over 20% of ABC DLBCL tumors, the CD79B or CD79A subunits of the BCR are somatically mutated so as to perturb their ITAM signaling motifs. (nih.gov)
- Ca(II) / calmodulin complex binds to and stimulates Ca(II)/calmodulin-dependent protein kinases CaMKK , CaMKII and CaMKIV . (bio-rad.com)
- P61959.1 MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY 1367453_at NP_446195 6.42 hsp90 co-chaperone Cdc37 Cdc37 Rattus norvegicus " Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. (nih.gov)
- The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
- Knockdown of any BCR subunit or downstream kinases in this pathway proved lethal for ABC DLBCL cell lines because this pathway engages the anti-apoptotic NF-kB module. (nih.gov)
- Here, we describe a principled Bayesian approach, BANDLE, that uses these data to compute the probability that a protein differentially localises upon cellular perturbation. (nature.com)
- Condensates separation from the surrounding CYTOPLASM or nucleoplasm or by the concentration of proteins and nucleic acids into droplets as they aggregate on static cellular structures such as CELL MEMBRANES. (nih.gov)
- This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
- Under oxidative stress conditions, excessive ROS can damage cellular proteins, lipids, and DNA, leading to cell damage that may contribute to carcinogenesis. (hindawi.com)
- H 2 O 2 is the more stable and diffusible form of ROS, it is selectively reactive towards cysteine residues on proteins, and, in the low nanomolar range, it can control cellular signaling (Figure 1 ). (hindawi.com)
- Light exposure triggers movement of certain signaling proteins within the cellular compartments of the highly polarized rod photoreceptor cell. (biomedcentral.com)
- protein adenosine generates almost been up by molecules via AQP1 and RhAG. (evakoch.com)
- Kidney Int Suppl 27: S205-S207  Mitch WE, Medina R, Grieber S, May Bllacklist, England Blackljst, Price SR, Bailey JL, Goldberg AL 1994 Meta- bolic acidosis stimulates muscle protein degrada- tion by activating the adenosine triphosphate-de- pendent pathway involving ubiquitin and protea- somes. (forexsanity.com)
Calmodulin dependent protein1
- calcium/calmodulin dependent protein k. (gsea-msigdb.org)
- Unfortunately, most fixative agents can damage or destroy nucleic acids (RNA and DNA) and damage proteins during the fixation process, thereby potentially impairing diagnostic assessment of tissue. (nih.gov)
- The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. (embl.de)
- Genetic interaction study shows that Drice mediates its action by regulating Rho1GTPase functionally, and localization of polarity protein Disc large . (sdbonline.org)
- Neh6 domain contains two redox-independent degrons DSGIS and DSAPGS that bind to E3 ubiquitin ligase β-transducin repeat-containing protein (βTrCP), which mediates NRF2 degradation in oxidatively stressed cells ( Figure 1 C) [ 4 ] . (encyclopedia.pub)
- A fragment containing the N-terminal 272 amino acid residues of KRIT1, a region lacking similarity to any known protein upon database searches, was used as bait. (nih.gov)
- Work in our laboratory focuses on the molecular machineries that mediate these processes, including (1) sorting signals and adaptor proteins that select cargo proteins for packaging into the transport carriers, (2) microtubule motors and their cognate adaptors that drive movement of the transport carriers and other organelles through the cytoplasm, and (3) tethering factors that promote fusion of the transport carriers to acceptor compartments. (nih.gov)
- In 1984 the dominant Environmental Card was identified for 38 DM per download data mining( US at the phosphorylation) for molecular collapse within the damaged subunits( contrary and thesis). (evakoch.com)
- Missense variant protein expression and BAF subunit interactions were examined using 3D protein modeling, co-immunoprecipitation, and proximity-ligation assays. (bvsalud.org)
- We hypothesize that the cell-selective nuclear import of the smooth muscle gamma actin (SMGA) promoter is mediated by the transcription factors SRF and Nkx3.1/3.2 that are expressed in smooth muscle cells but not other cells of the airway. (americanasthmafoundation.org)
- A recurrent theme that emerges from these unbiased genetic approaches is that the lymphoid malignancies co-opt signaling proteins and transcription factors that are used in normal B cell differentiation and activation. (nih.gov)
- In previous work, we showed that tyrosine-based signals bind to a conserved site on the mu1, mu2 and mu3 subunits of three hetero-tetrameric adaptor protein (AP) complexes, AP-1, AP-2 and AP-3, respectively. (nih.gov)
- We subsequently found that a subset of tyrosine-based sorting signals fitting the consensus motif YXX[FL]E (where X is any amino acid) bind to the mu4 subunit of another AP complex named AP-4. (nih.gov)
- 4. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. (nih.gov)
- 7. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. (nih.gov)
- 15. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. (nih.gov)
- remaining its protein by a tyrosine in 2007, the sensitivity of Greensburg, Kansas( United States) primed to be to predominantly additional secretory effector phosphorylated coreceptors. (erik-mill.de)
- actin related protein 2/3 complex subu. (gsea-msigdb.org)
- Emerging evidence shows that NRF2 lies at the center of a complex regulatory network and establishes NRF2 as a truly pleiotropic transcription factor. (encyclopedia.pub)
- Here we summarize the complex regulatory network of NRF2 activity and its roles in metabolic reprogramming, unfolded protein response, proteostatsis, autophagy, mitochondrial biogenesis, inflammation, and immunity. (encyclopedia.pub)
- Here we show that BRCA1a and BRCA1b proteins stimulate p53-dependent transcription from the p21WAF1/CIP1 promoter. (embl.de)
- Dileucine-based signals, on the other hand, bind to a different site on the surface of two subunits, gamma-sigma1, alpha-sigma2 and delta-sigma3, of the corresponding AP-1, AP-2 and AP-3 complexes. (nih.gov)
- Extracellular and organization of tissue-specific proteins and polysaccharides. (nih.gov)
- Over 150 enzymes contain known removed in proteins, and Similarly a download data mining and predictive analysis intelligence of these is located found. (evakoch.com)
- the C other requirements anterior and is the enzymes of the sialylated subunit of the Binding peroxidase. (evakoch.com)
- Both mitochondria and chloroplast use their DNA to produce many proteins and enzymes required for their function  . (madridge.org)
- Mitochondrial outer membrane permeability is conferred by a family of porin proteins. (madridge.org)
- The porins in the outer membrane allow the passage of molecules smaller than 5 kilodaltons besides the large multiprotein translocase complex that recognizes mitochondrial signal sequences on larger proteins and permits their passage. (madridge.org)
- Each of these compartments is aligned in the layered structure of the retina (Fig. 1a ), and each contains unique molecular signatures and protein complexes [ 2 - 4 ]. (biomedcentral.com)
- Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
- These findings demonstrate that AP-4 assembly is not spontaneous but AAGAB-assisted, further contributing to the understanding of an adaptor protein complex that is critically involved in development of the central nervous system. (nih.gov)
- Our findings demonstrate an additional function for this domain in protein-protein interaction and co-activation of p53. (embl.de)
- Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
- Processes that impede normal trafficking of these abundant proteins lead to cell death. (biomedcentral.com)
- Stress granules (SGs) constitute a cytoplasmic non-membranous compartment formed by RNA-protein aggregates, which control RNA metabolism, signaling, and survival under stress. (biomed.news)
- 10. Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences. (nih.gov)
- The BRCT domain is not limited to the C-terminal of protein sequences and can be found in multiple copies or in a single copy as in RAP1 and TdT. (embl.de)
- ADAM10 is a component of the postsynaptic density, and its trafficking is controlled by the interaction between its cytoplasmic C-terminal tail and specific protein partners: synapse-associated protein 97 (SAP97) and clathrin adaptor hetero-tetramer AP2. (nih.gov)
- Some data [ ( PUBMED:9799248 ) ] indicate that the BRCT domain functions as a protein-protein interaction module. (embl.de)
- These results demonstrate for the first time the presence of a second p53 interaction domain in BRCA1 proteins and suggests that BRCA1a and BRCA1b proteins, like BRCA1, function as p53 co-activators. (embl.de)
- expression cross-links are proven in a universal hydrolysis of Kainate primary functions, comprising Transport as adaptors, cities or CDH1 receptors. (evakoch.com)
- SLC6A20 requires the E2F4 and numerous sulfate membrane and does the severe T of addition strategies enterocyte-like as L-proline, N-methyl-L-proline and membrane-bound also usually as suitable complex UDP-glucuronosyltransferases and intestine( Broer & Gether 2012, Schweikhard & Ziegler 2012). (erik-mill.de)
- The combination therapy also promoted the increase in the levels of the following OC-related proteins: TLR4, MyD88, TRIF, inhibitor of phosphorylated NF-kB alpha (p-IkBα), and nuclear factor kappa B (NF-kB p65) in both cytoplasmic and nuclear sites. (biomedcentral.com)
- therefore, using a structure-based virtual screen analysis, we identified lomitapide, a cholesterol-lowering drug, as a potential mTOR complex 1 (mTORC1) inhibitor. (biomed.news)
- These localisations are context specific with proteins translocating between different subcellular niches upon perturbation of the subcellular environment. (nature.com)
- Differential localisation, that is a change in the steady-state subcellular location of a protein, provides a step towards mechanistic insight of subcellular protein dynamics. (nature.com)
- Proteins are localised to these niches in accordance to their function and thus to shed light on the function of a protein, it is necessary to determine its subcellular location. (nature.com)
- The COPII subunit, Sec31 , and ER exit site protein, Sec16 , are critical for subcellular tube architecture, whereas the SNARE proteins Syntaxin 5 , Syntaxin 1 and Syntaxin 18 are more generally required for seamless tube growth and maintenance. (sdbonline.org)
- Previous studies emphasized the importance of the BRCT domain, which shows homology with p53 binding protein (53BP1), in transcriptional activation, growth inhibition and tumor suppression. (embl.de)
- These results suggest that one of the mechanisms by which BRCA1 proteins function is through recruitment of CBP/p300 associated HAT/FAT activity for acetylation of p53 to specific promoters resulting in transcriptional activation. (embl.de)
- NRF2 activity is tightly regulated through a complex transcriptional and post-translational network that enables it to orchestrate the cell's response and adaptation to various pathological stressors for the homeostasis maintenance. (encyclopedia.pub)
- This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. (nih.gov)
- This complex localizes to the TGN, but until recently its function was unknown. (nih.gov)
- May function in protein sorting in late endosomes or multivesucular bodies (MVBs). (nih.gov)
- Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
- The steady-state localisation of proteins provides vital insight into their function. (nature.com)
- As the function of the KRIT1 protein and its role in CCM pathogenesis remain unknown, we performed yeast two-hybrid screens to identify additional protein binding partners. (nih.gov)
- unvisualizable clear gels in Windsor, Victoria, Australia by DesignInc( 2006) is free distinct History, short and FACIT proteins, outer patients, process nucleotide, amine cell and institutional open form. (erik-mill.de)
- This redistribution of proteins between the inner and outer segment compartments affects the performance and physiology of the rod cell. (biomedcentral.com)
- In addition, newly synthesized phototransduction proteins traverse from the site of their synthesis in the inner segment, through the thin connecting cilium, to reach their destination in the outer segment. (biomedcentral.com)
- We introduce two peeling methods that efficiently and reliably isolate the rod outer segment and other cell compartments for Western blots to examine protein movement across these compartments. (biomedcentral.com)
- These results demonstrate the effectiveness of the two different peeling protocols for the separation of the layered compartments of the mouse retina and their utility for investigations of protein compositions within these compartments. (biomedcentral.com)
- NGF is gamma-aminobutyric membrane of cathepsin, a Vitamin of the MAPK membrane( Morooka synthetase, Nishida E, 1998). (evakoch.com)
- The architecture of Nuclear factor erythroid 2-related factor 2 (NRF2), Kelch-like-ECH-associated protein 1 (KEAP1), and β-transducin repeat-containing protein (βTrCP). (encyclopedia.pub)
- The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. (nih.gov)
- Dr. Li played an important role in the NIH Roadmap for Medical Research, created by the NIH in 2003 to support cross-cutting, trans-NIH programs that fill fundamental knowledge and technology gaps, and encourage innovative, high-risk/high-reward approaches to complex biomedical problems. (nih.gov)
- Reconstitution of nuclear protein export in isolated nuclear envelopes. (duke.edu)
- family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus ) are complex, double-stranded DNA viruses with ongoing interest because of their potential use as bioterrorism agents and in gene therapy. (cdc.gov)
- Because immunotherapies have emerged as the adjuvant treatment for patients with OC, we investigated the effect of a promising immunotherapeutic strategy based on protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride (P-MAPA) combined with cisplatin (CIS) on the TLR2 and TLR4 signaling pathways via myeloid differentiation factor 88 (MyD88) and TLR-associated activator of interferon (TRIF) in an in vivo model of OC. (biomedcentral.com)
- Interestingly, Drosophila Malpighian tubules (MTs) express apoptotic proteins, without succumbing to cell death. (sdbonline.org)
- The identification of proteins that interact with AP-4 has shed light on the mechanisms of AP-4-dependent cargo sorting and distribution within the cell. (nih.gov)
- However, the mechanisms by which the AP-4 complex itself is assembled have remained unknown. (nih.gov)
- Knowledge gained from this basic research is applied to the elucidation of disease mechanisms, including congenital disorders of protein traffic such as the pigmentation and bleeding disorder Hermansky-Pudlak syndrome (HPS) and various neurodevelopmental and neurodegenerative disorders (e.g., hereditary spastic paraplegias and pontocerebellar hypoplasias). (nih.gov)
- multiple cross-links are organic in often all normal surfaces where they suffer acylated first pathways been on their G-protein download data mining and predictive analysis intelligence gathering and. (evakoch.com)
- the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
- Also in the OS are other membrane proteins, membrane-associated and soluble proteins that are important for phototransduction and for the structural integrity of the OS [ 2 ]. (biomedcentral.com)
- This study, demonstrated that anterograde trafficking, retrograde trafficking and Golgi-to-plasma membrane vesicle fusion are each required for the complex branched architecture of the terminal cell, but their inputs during seamless lumen formation are more varied. (sdbonline.org)