Adaptor Protein Complex gamma Subunits: A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.Adaptor Protein Complex 3: An adaptor protein complex found primarily on perinuclear compartments.Adaptor Protein Complex 1: A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.Adaptor Protein Complex 2: An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.Adaptor Protein Complex 4: An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.Adaptor Protein Complex Subunits: The subunits that make up the large, medium and small chains of adaptor proteins.Adaptor Protein Complex delta Subunits: A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.Adaptor Protein Complex mu Subunits: A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.Adaptor Proteins, Vesicular Transport: A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.Adaptor Protein Complex beta Subunits: A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.Adaptor Protein Complex alpha Subunits: A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesClathrin: The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.Human Characteristics: The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)Monomeric Clathrin Assembly Proteins: A subclass of clathrin assembly proteins that occur as monomers.Endosomes: Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.Period Circadian Proteins: Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Cryptochromes: Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.BooksPhysicians: Individuals licensed to practice medicine.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Accidents, Traffic: Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.Book SelectionJournal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Libraries, MedicalEnzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Citrullus: A plant genus of the family CUCURBITACEAE known for the edible fruit.Reindeer: A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Taq Polymerase: A heat stable DNA-DIRECTED DNA POLYMERASE from the bacteria Thermus aquaticus. It is widely used for the amplification of genes through the process of POLYMERASE CHAIN REACTION. EC 2.7.7.-.Genotyping Techniques: Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Gene Frequency: The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.

Early embryonic death of mice deficient in gamma-adaptin. (1/69)

Intracellular protein transport and sorting by vesicles in the secretory and endocytic pathways requires the formation of a protein coat on the membrane. The heterotetrameric adaptor protein complex 1 (AP-1) promotes the formation of clathrin-coated vesicles at the trans-Golgi network. AP-1 interacts with various sorting signals in the cytoplasmic tails of cargo molecules, thus indicating a function in protein sorting. We generated mutants of the gamma-adaptin subunit of AP-1 in mice to investigate its role in post-Golgi vesicle transport and sorting processes. gamma-Adaptin-deficient embryos develop until day 3.5 post coitus and die during the prenidation period, revealing that AP-1 is essential for viability. In heterozygous mice the amount of AP-1 complexes is reduced to half of controls. Free beta1- or micro1 chains were not detectable, indicating that they are unstable unless they are part of AP-1 complexes. Heterozygous mice weigh less then their wild-type littermates and show impaired T cell development.  (+info)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (2/69)

We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1 and 3 positions of the 2-deoxystreptamine moiety of the antibiotics. These two amines appear to mimic the epsilon-amino groups present in the two lysine residues of the KKXX motif that is known to bind coatomer. Here we report the effects of 1, 3-cyclohexanebis(methylamine) (CBM) on secretion in vivo, a compound chosen for study because it contains primary amino groups that resemble those in 2-deoxystreptamine and it should penetrate lipid bilayers more readily than antibiotics. CBM inhibited coatomer binding to Golgi membranes in vitro and in vivo and inhibited secretion by intact cells. Despite depressed binding of coatomer in vivo, the Golgi complex retained its characteristic perinuclear location in the presence of CBM and did not fuse with the endoplasmic reticulum (ER). Transport from the ER to the Golgi was also not blocked by CBM. These data suggest that a full complement of coat protein I (COPI) on membranes is not critical for maintenance of Golgi integrity or for traffic from the ER to the Golgi but is necessary for transport through the Golgi to the plasma membrane.  (+info)

Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. (3/69)

Insulin stimulates adipose cells both to secrete proteins and to translocate the GLUT4 glucose transporter from an intracellular compartment to the plasma membrane. We demonstrate that whereas insulin stimulation of 3T3-L1 adipocytes has no effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipocyte complement related protein of 30 kD (ACRP30) is markedly enhanced. Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme. Thus, 3T3-L1 adipocytes possess a regulated secretory compartment containing ACRP30. Whether GLUT4 recycles to such a compartment has been controversial. We present deconvolution immunofluorescence microscopy data demonstrating that the subcellular distributions of ACRP30 and GLUT4 are distinct and nonoverlapping; in contrast, those of GLUT4 and the transferrin receptor overlap. Together with supporting evidence that GLUT4 does not recycle to a secretory compartment via the trans-Golgi network, we conclude that there are at least two compartments that undergo insulin-stimulated exocytosis in 3T3-L1 adipocytes: one for ACRP30 secretion and one for GLUT4 translocation.  (+info)

Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. (4/69)

The AP-1 adaptor complex is associated with the TGN, where it links selected membrane proteins to the clathrin lattice, enabling these proteins to be concentrated in clathrin-coated vesicles. To identify other proteins that participate in the clathrin-coated vesicle cycle at the TGN, we have carried out a yeast two- hybrid library screen using the gamma-adaptin subunit of the AP-1 complex as bait. Two novel, ubiquitously expressed proteins were found: p34, which interacts with both gamma-adaptin and alpha-adaptin, and gamma-synergin, an alternatively spliced protein with an apparent molecular mass of approximately 110-190 kD, which only interacts with gamma-adaptin. gamma-Synergin is associated with AP-1 both in the cytosol and on TGN membranes, and it is strongly enriched in clathrin-coated vesicles. It binds directly to the ear domain of gamma-adaptin and it contains an Eps15 homology (EH) domain, although the EH domain is not part of the gamma-adaptin binding site. In cells expressing alpha-adaptin with the gamma-adaptin ear, a construct that goes mainly to the plasma membrane, much of the gamma-synergin is also rerouted to the plasma membrane, indicating that it follows AP-1 onto membranes rather than leading it there. The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins.  (+info)

Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains. (5/69)

The molecular basis of the selectivity and the details of the vesicle formation in endocytic and secretory pathways are still poorly known and most probably involve as yet unidentified components. Here we describe the cloning, expression, and tissue and cell distribution of a novel protein of 67 kDa (called Vear) that bears homology to several endocytosis-associated proteins in that it has a VHS domain in its N terminus. It is also similar to gamma-adaptin, the heavy subunit of AP-1, in having in its C terminus a typical "ear" domain. In immunofluorescence microscopy, Vear was seen in the Golgi complex as judged by a typical distribution pattern, a distinct colocalization with the Golgi marker gamma-adaptin, and a sensitivity to treatment of cells with brefeldin A. In cell fractionation, Vear partitioned with the post-nuclear membrane fraction. In transfection experiments, hemagglutinin-tagged full-length Vear and truncated Vear lacking the VHS domain assembled on and caused compaction of the Golgi complex. Golgi association without compaction was seen with the ear domain of Vear, whereas the VHS domain alone showed a diffuse membrane- and vesicle-associated distribution. The Golgi association and the bipartite structure along with the differential targeting of its domains suggest that Vear is involved in heterotypic vesicle/suborganelle interactions associated with the Golgi complex. Tissue-specific function of Vear is suggested by its high level of expression in kidney, muscle, and heart.  (+info)

A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. (6/69)

We have cloned and characterized members of a novel family of proteins, the GGAs. These proteins contain an NH(2)-terminal VHS domain, one or two coiled-coil domains, and a COOH-terminal domain homologous to the COOH-terminal "ear" domain of gamma-adaptin. However, unlike gamma-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes. Immunogold EM shows that these membranes correspond to trans elements of the Golgi stack and the TGN. GST pulldown experiments indicate that the GGA COOH-terminal domains bind to a subset of the proteins that bind to the gamma-adaptin COOH-terminal domain. In yeast there are two GGA genes. Deleting both of these genes results in missorting of the vacuolar enzyme carboxypeptidase Y, and the cells also have a defective vacuolar morphology phenotype. These results indicate that the function of the GGAs is to facilitate the trafficking of proteins between the TGN and the vacuole, or its mammalian equivalent, the lysosome.  (+info)

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. (7/69)

Formation of intracellular transport intermediates and selection of cargo molecules are mediated by protein coats associated with the cytosolic face of membranes. Here, we describe a novel family of ubiquitous coat proteins termed GGAs, which includes three members in humans and two in yeast. GGAs have a modular structure consisting of a VHS domain, a region of homology termed GAT, a linker segment, and a region with homology to the ear domain of gamma-adaptins. Immunofluorescence microscopy showed colocalization of GGAs with Golgi markers, whereas immunoelectron microscopy of GGA3 revealed its presence on coated vesicles and buds in the area of the TGN. Treatment with brefeldin A or overexpression of dominant-negative ADP ribosylation factor 1 (ARF1) caused dissociation of GGAs from membranes. The GAT region of GGA3 was found to: target a reporter protein to the Golgi complex; induce dissociation from membranes of ARF-regulated coats such as AP-1, AP-3, AP-4, and COPI upon overexpression; and interact with activated ARF1. Disruption of both GGA genes in yeast resulted in impaired trafficking of carboxypeptidase Y to the vacuole. These observations suggest that GGAs are components of ARF-regulated coats that mediate protein trafficking at the TGN.  (+info)

Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells. (8/69)

Expression of the epithelial cell-specific heterotetrameric adaptor complex AP-1B is required for the polarized distribution of many membrane proteins to the basolateral surface of LLC-PK1 kidney cells. AP-1B is distinguished from the ubiquitously expressed AP-1A by exchange of its single 50-kD mu subunit, mu1A, being replaced by the closely related mu1B. Here we show that this substitution is sufficient to couple basolateral plasma membrane proteins, such as a low-density lipoprotein receptor (LDLR), to the AP-1B complex and to clathrin. The interaction between LDLR and AP-1B is likely to occur in the trans-Golgi network (TGN), as was suggested by the localization of functional, epitope-tagged mu1 by immunofluorescence and immunoelectron microscopy. Tagged AP-1A and AP-1B complexes were found in the perinuclear region close to the Golgi complex and recycling endosomes, often in clathrin-coated buds and vesicles. Yet, AP-1A and AP-1B localized to different subdomains of the TGN, with only AP-1A colocalizing with furin, a membrane protein that uses AP-1 to recycle between the TGN and endosomes. We conclude that AP-1B functions by interacting with its cargo molecules and clathrin in the TGN, where it acts to sort basolateral proteins from proteins destined for the apical surface and from those selected by AP-1A for transport to endosomes and lysosomes.  (+info)

Genetic information processingProtein fateProtein and peptide secretion and traffickingprotein translocase SEC61 complex gamma subunit, archaeal and eukaryotic (TIGR00327; HMM-score: 8.1) ...
Warner Bros. announced today the release dates of two high-profile film adaptations, the Clint Eastwood-directed Jersey Boys and Ben Afflecks Live By Night.
Bedste ⭐ 31 grunde for Sony SRS-X77 vs Clint Freya: 1. højde 2. bredte 3. kontrolpanelet sidder på selve enheden 4. har indbygget stereo højtaler 5. vægt 6. volume
Sarah had on heading activities for developing the synthetic SITC base read clint eastwood loaded on the set. transfer broke share some of the useful solutions and major. Ali did clinical in the Critical sex, catalog, and resolve of The Observatory.
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected]mp.org, US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
Reaktivität: Huhn, Rind (Kuh), Hund and more. 17 verschiedene AP2M1 ELISA Kits vergleichen. Alle direkt auf antikoerper-online.de bestellbar!
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
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The structure of the appendage domain of β2 adaptin is similar to that of α‐adaptin in that it has two subdomains with similar topology, but with a difference of ∼46° in the orientation between the two subdomains. Like the α‐appendage, the β2‐appendage domain binds AP180, epsin and eps15, and therefore is likely to be involved in recruiting proteins involved in controlling CCV formation to sites of coated pit formation in vivo. The two proteins possess a partly conserved binding site of high hydrophobic potential on the C‐terminal platform domain, suggesting that they bind similar motifs i.e. DΦF/W. The binding site residues are also conserved in β1‐adaptin from the adaptor AP1, so this homologue would be predicted to bind the same ligands as β2. Indeed, a GSTβ1 appendage construct does bind to eps15, and weakly to clathrin and epsin (data not shown). Although the α and β2 appendages share some of the same ligands, they bind to them with different relative affinities: the ...
AP4M1 antibody [N1C1] (adaptor-related protein complex 4, mu 1 subunit) for IHC-P, WB. Anti-AP4M1 pAb (GTX115196) is tested in Human, Mouse samples. 100% Ab-Assurance.
AP3S1 antibody (adaptor-related protein complex 3, sigma 1 subunit) for ELISA, ICC/IF, IHC-P, WB. Anti-AP3S1 pAb (GTX31839) is tested in Human, Mouse samples. 100% Ab-Assurance.
VHS domains are found at the N-termini of select proteins involved inintracellular membrane trafficking. We have determined the crystalstructure of the VHS domain of the human Tom1 (target of myb 1) protein to1.5 A resolution. The domain consists of eight helices arranged in asuperhelix. The surface of the domain has two main features: (1) a basicpatch on one side due to several conserved positively charged residues onhelix 3 and (2) a negatively charged ridge on the opposite side, formed byresidues on helix 2. We compare our structure to the recently obtainedstructure of tandem VHS-FYVE domains from Hrs [Mao, Y., Nickitenko, A.,Duan, X., Lloyd, T. E., Wu, M. N., Bellen, H., and Quiocho, F. A. (2000)Cell 100, 447-456]. Key features of the interaction surface between theFYVE and VHS domains of Hrs, involving helices 2 and 4 of the VHS domain,are conserved in the VHS domain of Tom1, even though Tom1 does not have aFYVE domain. We also compare the structures of the VHS domains of Tom1 andHrs to the ...
Analyses with the yeast two-hybrid system showed that the cytosolic tail of the human CI-MPR interacted with full-length GGA3 as well as with the ∼150-amino acid VHS domain, but not the GAT or GAE domains of GGA3 (Fig. 1C). Further analyses revealed that the CI-MPR tail interacted with the VHS domains of all three GGAs and that the CD-MPR tail interacted with the VHS domains of GGA1 and, more weakly, GGA3 (Fig. 1D). These interactions were highly specific, because neither MPR tail bound to the VHS domains of STAM1, HRS, TOM1, and TOM1L1 (Fig. 1D). Likewise, we did not detect interactions between the GGA VHS domains and the cytosolic tails of TGN38, TRP2, tyrosinase, TRP1, LAMP-2, LIMP II, low density lipoprotein (LDL) receptor, β-amyloid precursor, and transferrin receptor (Fig. 1D), which contain either tyrosine-based sorting signals or dileucine-based sorting signals devoid of acidic clusters.. Deletion of the acidic-cluster-dileucine signals from the CI-MPR and CD-MPR tails abolished ...
Monoklonale und polyklonale gamma 1 Adaptin Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für gamma 1 Adaptin Antikörper. Hier bestellen.
I found Clint in my front yard. He was starving and had scabies. I named him Clint for Clint Eastwood because hes tough! He is the sweetest cat. I took him to the vet and he is doing great! He has gained over a pound and he is adorable.. ...
Calories in Clint & Sons Black Label Beef Jerky. Find nutrition facts for Clint & Sons Black Label Beef Jerky and over 2,000,000 other foods in MyFitnessPal.coms food database.
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
How do you define health? Physical? Mental? Social? Health goes beyond medical care. Its how we take care of ourselves, how we interact with our communities, how we take care of each other ...
The calcium-sensing receptor (CASR) is the main calcium sensor in the maintenance of calcium metabolism. Mutations of the CASR, the G protein alpha 11 (GNA11) and the adaptor-related protein complex 2 sigma 1 subunit (AP2S1) genes can shift the set point for calcium sensing causing hyper- or hypo-calcemic disorders. Therapeutic concepts for these rare diseases range from general therapies of hyper- and hypo-calcemic conditions to more pathophysiology oriented approaches such as parathyroid hormone (PTH) substitution and allosteric CASR modulators. Cinacalcet is a calcimimetic that enhances receptor function and has gained approval for the treatment of hyperparathyroidism. Calcilytics in turn attenuate CASR activity and are currently under investigation for the treatment of various diseases. We conducted a literature search for reports about treatment of patients harboring inactivating or activating CASR, GNA11 or AP2S1 mutants and about in vitro effects of allosteric CASR modulators on mutated ...
EpsinR is a clathrin-coated vesicle (CCV) enriched 70-kD protein that binds to phosphatidylinositol-4-phosphate, clathrin, and the gamma appendage domain of the adaptor protein complex 1 (AP1). In cells, its distribution overlaps with the perinuclear pool of clathrin and AP1 adaptors. Overexpression disrupts the CCV-dependent trafficking of cathepsin D from the trans-Golgi network to lysosomes and the incorporation of mannose-6-phosphate receptors into CCVs. These biochemical and cell biological data point to a role for epsinR in AP1/clathrin budding events in the cell, just as epsin1 is involved in the budding of AP2 CCVs. Furthermore, we show that two gamma appendage domains can simultaneously bind to epsinR with affinities of 0.7 and 45 microM, respectively. Thus, potentially, two AP1 complexes can bind to one epsinR. This high affinity binding allowed us to identify a consensus binding motif of the form DFxDF, which we also find in gamma-synergin and use to predict that an uncharacterized EF-hand
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Arsenic atom in PDB 1r4x: Crystal Structure Analys of the Gamma-Copi Appendage Domain
Geoffrey Lewis, a prolific character actor who appeared opposite frequent collaborator Clint Eastwood in several movies, has died. He was 79.
I have been hearing more and more these days about groups moving to the unconference model. An unconference has no speakers and attendees only participants. Dave Winer coined this term and this idea in 1998 (See his definition here or Doc Searls here). His fundamental principal is: The sum of the expertise of the people…
IMDbs advanced search allows you to run extremely powerful queries over all people and titles in the database. Find exactly what youre looking for!
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011 ...
Study VIII - Environmental and Nutritional Diseases flashcards from Clint Benson Valdeavilla's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
On Thursday, October 26th, The Mental Health Association of Westchester welcomed former NHL all-star goalie Clint Malarchuk and his wife Joanie for a riveting and unforgettable evening of conversation.
The Yankees have placed Clint Frazier on the 10-day disabled list with a left oblique strain and have reactivated Aaron Hicks, the team announced. Frazier was penciled into the lineup Wednesday against the Blue Jays but was a late scratch because of the injury. He said hed been experiencing pain over the past few days, but it came to a head during batting practice. "Ive been feeling it for a few days," Frazier told reporters Wednesday. "It definitely wasnt in BP today. I was feeling some discomfort in my side. Its not any worse. Its maintained its discomfort level. Its just a matter of wanting to make sure everythings all right before I keep going."Ive been telling [the trainers] its been pretty tender the last few days. I think Joe just saw me fiddling with my side in BP today and just wanted to give me a day.". Hicks was placed on the DL in late June with the same injury as Frazier. The outfielder had been on a rehab assignment with Triple-A Scranton and Double-A Trenton, where he ...
Read Matter of Inches by Clint Malarchuk, Dan Robson for free with a 30 day free trial. Read unlimited* books and audiobooks on the web, iPad, iPhone and Android.
If you experience ongoing pain in the area near your ear, your jaw or the muscles on the side of your face, possibly accompanied by a clicking or popping sound
AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene. This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. AP3B1 has been shown to interact with AP3S2. GRCh38: Ensembl release 89: ENSG00000132842 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021686 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". DellAngelica EC, Ooi CE, Bonifacino JS (Jun 1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". The Journal of Biological Chemistry. 272 (24): 15078-84. doi:10.1074/jbc.272.24.15078. PMID 9182526. Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". The ...
Looking for online definition of Golgi adaptor HA1/AP1 adaptin sigma-1C subunit in the Medical Dictionary? Golgi adaptor HA1/AP1 adaptin sigma-1C subunit explanation free. What is Golgi adaptor HA1/AP1 adaptin sigma-1C subunit? Meaning of Golgi adaptor HA1/AP1 adaptin sigma-1C subunit medical term. What does Golgi adaptor HA1/AP1 adaptin sigma-1C subunit mean?
Kinetics of B-fragment transport from EE/RE to the Golgi apparatus. (A) Confocal microscopy on living HeLa cells. Fluorophore-labeled B-fragment was internalize
Clint Howard, Actor: Apollo 13. Clint Howard also had a recurring role in The Andy Griffith Show, as a little boy always dressed in a cowboy outfit and always eating a peanut butter and jelly sandwich. He never said a word, but was always offering someone a bite. He also had a co-starring role along with a black bear as the owner and friend of Gentle Ben, in that series.
In the first part of this work, LC-MS data were used to calculate the in-vitro intrinsic clearances (CLint) for the metabolism of p-methoxyrnethamphetamine (PMMA) and fluoxetine by the CYP2D6 enzyme using a steady-state (SS) approach and a new general enzyme (GE) screening method. For PMMA, the SS experiment resulted in a CLint of 2.7 ± 0.2 µL pmol 2D6-1min-1 and the GE experiment resulted in a CLint of 3.0 ± 0.6 µL pmol 2D6-1min-1. For fluoxetine, the SS experiment resulted in a CLint of 0.33 ± 0.17 µL pmol 2D6-1min-1 and the GE experiment resulted in a CLint of 0.188 ± 0.013 µL pmol 2D6-1min-1. The inhibition of PMMA metabolism by fluoxetine was also demonstrated.In the second part of the work, target factor analysis was used as part of a library search algorithm for the identification of drugs in LC-DAD chromatograms. The ability to resolve highly overlapped peaks using the spectral data afforded by the DAD is what distinguished this method from conventional library searching methods. A
Visit Healthgrades for information on Dr. Clint Hill, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Movement: Probably Tuesday I felt something during the day, kind of like a thump that was a similar feeling to having the wind knocked out of you, but really light and only for a second. I wasnt sure if what I was feeling was the baby or not, so I didnt say anything to Clint. Then the next day, at around the same time, I felt the same thing again, and then the same feeling in the afternoon. So this time I called Clint and told him. The next evening we were watching TV and I told him I could feel the same thing, so he tried to "listen" to see if he could hear the baby. I felt a little kick but didnt say anything, and Clint immediately said "Was that it?" I was really surprised he could feel it too! Since then I can feel her movements a lot more regularly. The funniest day was Sunday at church, I stood up to sing and then sat back down, and I could feel her kick a few times. Then the next time we stood to sing, same thing happened. I think the service was disturbing her nap, and she wanted me ...
The chewing texture starts out feeling like pliable plastic, bending easily in my mouth. Theres some initial chewing resistance comparable to overcooked squid steak. Eventually it breaks down and with several chews and takes on a meaty feel, but not exactly like real steak. It still retains some of the chewy, rubbery feel ...
Students at Kuper Academy learned lessons about life on Thursday, courtesy of a former NHL player whos taken more than his share of hard knocks.
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type ...
Slyvester Stallone has already been talking up the next sequel in The Expendables franchise. Theres been a wishlist going around of actors hed like to appear in The Expendables 3 and Clint Eastwood is one of them. In an interview with Extra, the legendary actor, filmmaker and producer was asked whether hed appear in the sequel. When asked, it didnt seem that Eastwood even knew he was wanted in the film. He also stated that hes never seen the films nor has he seen any material in the form of a script. And in the end, his answer was an unfortunate "probably not" and that hed be more "apt to direct something…maybe Ill direct Expendables 3.". At the age of 82, the actor in classic films such as A Fist Full of Dollars, The Good, The Bad and The Ugly, Dirty Harry and City Heat - his prescence in The Expendables franchise would be the epitome of bringing in all of the great action stars that have doned their faces and bodies in cinema. But Im not sure if any form of TRT would be able to get ...
PLYMOUTH - At age 51, country music superstar Clint Black says his music is better than ever. Thats saying something, given he has been on top of the music charts for most of his career.
Clint Miller Exterminating offers free cockroach inspections and roach exterminating services in Mt. Pleasant, Concord, Salisbury, and surrounding areas. Schedule your roach inspection today.
Homo sapiens golgi associated, gamma adaptin ear containing, ARF binding protein 1 (GGA1), transcript variant 2, mRNA. (H00026088-R01) - Products - Abnova
Splinter Cell 3 and Far Cry 2 lead Clint Hocking stood down from Ubisoft Montreal back in May, citing a need to challenge himself and to leave comfortable
The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the…
Topical Antibiotics are applied to skin or mucous membranes to prevent and/or treat infections. These infections or potential infections are typically the result of exposure to bacteria.
While having dinner at the Palace, as they are waiting for test results, Viki and Clint begin to argue. Hes annoyed that Viki is able to eat when they should be worrying about Jess. Shes hungry, she has a heart condition and theres no sense in her getting sick too, she retorts. She prefers to stay positive and while he wants and needs definite answers, theyre just not available now. He, on the other hand, will probably have a stroke, she snaps. Maybe she wants him to, Clint snarls. At a nearby table, Britney is with her parents. They urge her to move on and get over Henry. She merely picked the wrong person to do her homework, her father says. She wants to head over to school to check the cast list for the musical, which gives her parents something else to criticize and mock. She just wants to have fun and shes already the school pariah. Shes not hungry and finally persuades them to let her leave, swiping a bottle of wine from another table on the way out. Miles runs into Dorian at Rodis ...
Although oral cancer may not get as much attention as some more widely-known types of cancer, that doesnt mean its any less deadly. In fact, it is estimated
Update 3/8: The prescribed medication stopped working as well as it had initially. Clint had more pain and swelling return early last week. While he was told he could increase dosage, he decided to try a remedy he read about online that would address all of the theories....garlic. Yep, garlic! And, it worked to help him with the pain and swelling! Noticeably! In fact, he has steadily improved since the weekend. He says 90-95% of the joint pain has left as of this morning. The other symptoms he was having have disappeared or have also diminished. He is taking a big spoonful of raw, minced garlic morning, noon, and night. We have our theories of what has happened, but thats all they are...theories. Clint goes to the doctor Friday and will go over what has happened since he last was seen. ...
Chloe was treated for septicemia and eventually made a full recovery. Chloe and Billy told Cane that Cordelia was not his child. Billy and Sharon got very drunk and slept together. Clint realized that Marge was really Katherine. Karen saw Neil and Tyra kiss.
My husband had texted to see how I was doing and if I could talk. While we were chatting our drive way beeper signaled that someone was on the property. Going into the dining room I looked for a car, but could not see one. Then I saw a man in the upper driveway and realized someone had parked there. My husband said to just go back to bed and not answer the door. We continued to chat, no doorbell rang and I forgot about it. A few minutes passed and I realized the driveway beeper had never acknowledged this cars departure, so with phone in hang I walked around the house trying to see what was going on. Looking out from the second story, I see a man peering in the bedroom sliding doors of the bedrooms below. Now he wasnt scary looking, actually a tall, strapping, blonde young man carrying a clipboard. Cranking open a window I called out, "May I help you?" It was the tax man, Clint, surveying the property! He could have passed for another one of Gods gorgeous angels though as he expressed with ...
How could I have missed out on this one, whos turned into a hottie while doing laudable work in a public hospital somewhere in the South? Filipino-Latvian model and nurse Clint Karklins has my vote for whatever contest hes in. Go ahead and add him on your Boys-To-Watch-Out-For while were in awe at his body of (modeling) work.. ...
... - Clinical trials, Fialuridine, TGN This page was last edited on 20 May , at In addition, no signs of toxicity were observed in any of the physiological
PDZK3兔多克隆抗体(ab96526)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
PDZK1兔多克隆抗体(ab64856)可与人样本反应并经WB, IHC, ICC/IF实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Our study provides evidence for a new role of Src in the phosphorylation of the clathrin adaptor complex AP-2 (via the phosphorylation of the β-subunit, i.e. β2-adaptin). We identify Y737 in the ear domain of β2-adaptin as an important Src target. We show that this residue represents a regulatory site for controlling the dissociation of β-arrestin from AP-2 in clathrin-coated pits (CCPs). Our results not only extend the pleiotropic function of Src in GPCR internalization, but also highlight the importance of receptor-dependent signaling in the clathrin-mediated endocytosis of AT1R.. β-arrestins are multifunctional adaptors involved in the endocytosis and signaling of many GPCRs (Claing et al., 2002; Lefkowitz, 1998). They have been shown to target receptors to CCPs through binding to clathrin and the β-subunit of AP-2 (Goodman, Jr et al., 1996; Laporte et al., 1999), and to act as signal transducers by recruiting different kinases to GPCRs (Luttrell and Luttrell, 2004). We have previously ...
Clint Eastwood has cast three young Americans who stopped a terrorist attack on a high-speed train to play themselves in The 15:17 to Paris, it was announced Tuesday.
Dr. Clint L Christensen, MD, rated 5/5 by patients. 1 reviews, Phone number & practice locations, Anesthesiologist in Salt Lake City, UT.
This protocol describes the immunofluorescent labeling technique used to identify serotonin expression in CtB-labelled phrenic motor neurons and within a defined region of interest...
Clint Boltons letter to Ann Fisher, August, 1979. (Clint Boltons authors note: This may or may not be fiction. There are those who live in the City Beside the Big River who will say of this or that character . . . That is Soando. And there are men . . . and women .…
Hi, I would like to ask you to support this blog by viewing one of the many ads listed below and sometimes posted in the article you chose to read. Also, I would like to thank you for taking the time to view any of the content of this Blog. I hope you find a post that interest you as well as a product or service that can help you out when needed. Most of the products or services are available worldwide so be sure to view the products home page by means of clicking on the ad itself if you are interested ...
A new rock music and pop culture website. Editorial independent music website offering news, reviews, features, interviews, videos and pictures
Football has its share of the improbablelike the time Chicago Cardinals? Clint Wagers prepared for a field goal attempt. Evidently his educated toe had its own ideas that day, for it missed the pork hide completely and slammed into his face, fracturing his jaw! (Maybe that explains why you-ve never heard of the Chicago Cardinals!). Or we could tell you all about the time a Rice player ran full speed toward a perfectly teed ball ready for the kickoff-only to land flat on his back. But we wont. Campus Life ...
The second episode of Road to the NHL Winter Classic was more about family than hockey, and that was appropriate with Chicago Blackhawks assistant equipment manager Clint Reifs passing over the weekend.
Whatever French film critics may say, Clint Eastwood is no pure-hearted artiste-his favored working regimen consists of a thick, undressed cut of genre skirt steak...
TITLE: Heist FORMAT: VHS Rated: R Year: 2002 Theatrical Release Date: STARRING: Danny DeVito, Delroy Lindo, Gene Hackman, Patti LuPone, R
Characterization of clathrin-coated vesicles isolated from MPR-deficient fibroblasts. The material contained in fractions 8 to 10 of the density gradients sho
My name is Clint. I live in Oklahoma. Im a designer, an illustrator, a coffee drinker, a bicycle rider, an over-analyzer, a beard grower, a music lover, a worrier, a lister-of-things. I draw under the alias Tillman Project. Do stuff, make stuff!
Clint Eastwood appeared on-stage at the Republican National Convention last night to show his support to the Republican candidate for the US presidency, Mitt Romney, and also to interview an empty chair, pretending that he was speaking to the current president, Barack Obama. The online community, typically, has had a humorous response.
I LOVE to ski!!! (steeper & deeper the better, but powder or slush bumps take the cake for me!) I enjoy organizing and am involved in multiple Meetup clubs. Also, SkiDUCK Rocks!
Do both systems develop at the same rate? Do both systems fatigue at the same rate? Is one system remaining undertrained/ held hostage by the other system? Does running fatigue the legs before the lungs? Can the legs be fatigued, but the lungs be good to go? Can the legs hold up to a 6-hour run? Can the lungs? Would the lungs benefit from a 6-hour run? Which system recovers quicker? Can you train the lungs and rest the legs? If so, how? If you can train you lungs while waiting for you legs to recover, why not do it? Do your lungs know the difference between running and cycling? Cycling and swimming ...
by Marion Smith. Chapter 13. [p.108]Baker to Barstow. Seventy-nine miles. Duncans driving. We have to talk or well explode.. "How would you judge me if you were on the jury?" I begin.. "Guilty. No question. Premeditated murder. If theres any strong evidence, which I dont think there will be. Then if I were the judge, Id sentence you to ten years, suspended, and give you a medal and a parade.". "You are my judge, dont you think?". "How about if Im your defense attorney instead? If I were judge, Id have to consider the social chaos when you take the law in your own hands. First wed name off the victims. Start with the three women Clint abused as a teenager in his old neighborhood who all went to Clints current bishop and stake president and told them their stories.". I take up the theme. "And the other four women whove called Katherine to tell her what Clint did to them when they were young-one of them also told her story to me personally.". "Who else do we know for sure from when he ...
A lot of lifters want to use these deadlift variations interchangeably, but Clint has a strong preference for one - and good reasoning to back it up.
Clint Dyer has been credited on games developed by the following companies: Sonic Team, Appaloosa Interactive Corporation, BlueSky Software, Inc., SEGA Games Co., Ltd., HeadGames, Inc., SEGA Interactive Development Division, SEGA of America, Inc., Clockwork Tortoise Inc., Sega AM3 R&D Division, Bell...
AMSAT area coordinator Clint Bradford, K6LCS, will be presenting his Working Amateur Satellites With Your HT multimedia session at a special joint session of the El Segundo, Hughes, and TRW amateur radio clubs. All are welcome to attend - but your RSVP is mandatory! This is a special date and location that weve worked out in order to accommodate these great clubs, Clint writes. And we have a tentative pass of satellite AO-51 at 5:45PM PDT that well be working from the parking lot. We will be meeting at the El Segundo Police Station EOC, 348 Main Street, El Segundo CA 90245. Satellite pass is at 5:45PM PDT. The presentation and clubs meeting starts at 7:30PM. The facility requires you to RSVP - please send your email to ... Grace, KJ6CMA, at arit701542 at aol.com BEFORE August 12, 2010. Attendees should download Clints four-page tutorial and radio programming matrix before the meeting from ... http://www.work-sat.com And Clint welcomes pre-presentation questions - call him at ...
Susan I. Vear, MD is a pediatric expert at Nationwide Childrens Hospital in Columbus, Ohio. Their biography includes professional experience, publications, research and clinical interests and more.
Clint Eastwood in the embodiement of machismo as we Make his day. Fear no man, no woman can refuse him. This strange cult of masculinity once being confined by labelling, if not in fact, to the world of the Latin - and particularly, Mexican,...
MTIs seismic evaluations include extensive information in accordance with Chapter 16 of the 2000 and 2003 editions of the International Building Code, including values for mapped spectral acceleration at short periods, and spectral acceleration at a 1-second periods. We further evaluate sites for characteristics particularly susceptible to seismic hazards and characterize the incidence and anticipated acceleration of seismic activity.. For more information, please contact:. Clint Wyllie, G.I.T ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ... and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, ...
... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... contains beta and gamma subunits. GRCh38: Ensembl release 89: ENSG00000058262 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ...
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located ... Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. ...
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Gamma-adaptin ear homology, ARF-binding proteins) adaptors. Adaptins are distantly related to the other main type of vesicular ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ...
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
The other large protein has different designations in the different complexes. In AP-1 it is named γ (gamma), AP-2 has α (alpha ... The two smaller proteins are a medium subunit named μ (mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ...
Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors. AP (adaptor protein) complexes are found in coated vesicles ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
... encoding protein cAMP-dependent protein kinase inhibitor gamma PLAGL2: encoding protein Zinc finger protein PLAGL2 POLR3F: ... encoding protein Kizuna centrosomal protein Kua-UEV: LIME1: encoding protein Lck-interacting transmembrane adapter 1 LZTS3: ... Glucocorticoid modulatory element-binding protein 2 GNAS1: Gs alpha subunit (membrane G-protein) GSS: glutathione synthetase ... encoding enzyme Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog VAPB: VAMP (vesicle-associated membrane protein ...
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ...
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ...
IFNγ suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, ... sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex ... including subunits of the immunoproteasome (MECL1, LMP2, LMP7), as well as TAP and ERAAP in addition possibly to the direct ... "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex". ...
2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an ... "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299- ... CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a ... T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or [email protected] It contributes ...
... associated protein Zap70 activated Zap70 in turn phosphorylates the membrane adaptor Lat, which subsequently recruits several ... In the naïve state, T cells are thought to be quiescent and non-dividing, requiring the common-gamma chain cytokines IL-7 and ... They also express functional IL-7 receptors, consisting of subunits IL-7 receptor-α, CD127, and common-γ chain, CD132. ... which results in phosphorylation of the CD3 coreceptor complex and ζ-chains of the TCR and activation of the ζ-chain- ...
... domain that is contained in the adaptor protein families Crk, Grb2, and Nck. These adaptor proteins then couple to enzymes to ... An activated complex of GAB2, SHC, and SHP2 is required for binding of Phospholipase C gamma 2 (PLCG2) through its SH2 domain, ... The p85 subunit of PI3K (or PIK3) possessed the SH2 domain required to be activated by GAB2. The activation of the PI3K ... GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking ...
... alpha 1 Adaptor-related protein complex 2, alpha 1 Aldehyde dehydrogenase 3 family, member A1 Aldehyde dehydrogenase 4 family, ... subunit, alpha 1 Protein kinase, AMP-activated, alpha 1 Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), ... member A1 Gamma-aminobutyric acid (GABA) A receptor, alpha 1 Gap junction protein, alpha 1 GDNF family receptor alpha 1 ... alpha 1 RNA binding motif protein, Y-linked, family 1, member A1 Replication protein A1 S100 calcium binding protein A1 Sec61 ...
"Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits ... including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765-71. doi: ...
"SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and ... "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (Mar 1994). "A complex of Grb2 adaptor protein, Sos exchange ...
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. The Fc-gamma receptors differ ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... For example, those that bind the most common class of antibody, IgG, are called Fc-gamma receptors (FcγR), those that bind IgA ...
"The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ... "Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking". Blood. 88 (2): 522-30. ... Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells ... with the p85 subunit of phosphoinositide 3-kinase". FEBS Lett. 575 (1-3): 35-40. doi:10.1016/j.febslet.2004.07.090. PMID ...
The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated. GRCh38 ... 2002). "Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells". ... 1996). "Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI ... Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for ...
"Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit". Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH ... Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma ... AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene. AP2A2 has been shown to interact with ... the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes ...
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. Adaptor protein complex 1 is found at the ... Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in ... "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; ... The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein ...
Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many ... G-protein coupled receptor signaling pathway. • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway. • G- ... clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2 unable to mobilize ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...
... a specialized complex composed of proteins, whose expression is induced by interferon gamma, are the primary producers of ... The complex formed with the specialized β subunits is known as the immunoproteasome.[16] Another β5i variant subunit, β5t, is ... the SCF itself is regulated by the APC via ubiquitination of the adaptor protein, Skp2, which prevents SCF activity before the ... The assembled complex of hslV (blue) and hslU (red) from E. coli. This complex of heat shock proteins is thought to resemble ...

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