Adaptor Protein Complex gamma Subunits: A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.Adaptor Protein Complex 3: An adaptor protein complex found primarily on perinuclear compartments.Adaptor Protein Complex 1: A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.Adaptor Protein Complex 2: An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.Adaptor Protein Complex 4: An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.Adaptor Protein Complex Subunits: The subunits that make up the large, medium and small chains of adaptor proteins.Adaptor Protein Complex delta Subunits: A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.Adaptor Protein Complex mu Subunits: A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.Adaptor Proteins, Vesicular Transport: A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.Adaptor Protein Complex beta Subunits: A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.Adaptor Protein Complex alpha Subunits: A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesClathrin: The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.Human Characteristics: The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)Monomeric Clathrin Assembly Proteins: A subclass of clathrin assembly proteins that occur as monomers.
(1/69) Early embryonic death of mice deficient in gamma-adaptin.

Intracellular protein transport and sorting by vesicles in the secretory and endocytic pathways requires the formation of a protein coat on the membrane. The heterotetrameric adaptor protein complex 1 (AP-1) promotes the formation of clathrin-coated vesicles at the trans-Golgi network. AP-1 interacts with various sorting signals in the cytoplasmic tails of cargo molecules, thus indicating a function in protein sorting. We generated mutants of the gamma-adaptin subunit of AP-1 in mice to investigate its role in post-Golgi vesicle transport and sorting processes. gamma-Adaptin-deficient embryos develop until day 3.5 post coitus and die during the prenidation period, revealing that AP-1 is essential for viability. In heterozygous mice the amount of AP-1 complexes is reduced to half of controls. Free beta1- or micro1 chains were not detectable, indicating that they are unstable unless they are part of AP-1 complexes. Heterozygous mice weigh less then their wild-type littermates and show impaired T cell development.  (+info)

(2/69) Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function.

We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1 and 3 positions of the 2-deoxystreptamine moiety of the antibiotics. These two amines appear to mimic the epsilon-amino groups present in the two lysine residues of the KKXX motif that is known to bind coatomer. Here we report the effects of 1, 3-cyclohexanebis(methylamine) (CBM) on secretion in vivo, a compound chosen for study because it contains primary amino groups that resemble those in 2-deoxystreptamine and it should penetrate lipid bilayers more readily than antibiotics. CBM inhibited coatomer binding to Golgi membranes in vitro and in vivo and inhibited secretion by intact cells. Despite depressed binding of coatomer in vivo, the Golgi complex retained its characteristic perinuclear location in the presence of CBM and did not fuse with the endoplasmic reticulum (ER). Transport from the ER to the Golgi was also not blocked by CBM. These data suggest that a full complement of coat protein I (COPI) on membranes is not critical for maintenance of Golgi integrity or for traffic from the ER to the Golgi but is necessary for transport through the Golgi to the plasma membrane.  (+info)

(3/69) Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4.

Insulin stimulates adipose cells both to secrete proteins and to translocate the GLUT4 glucose transporter from an intracellular compartment to the plasma membrane. We demonstrate that whereas insulin stimulation of 3T3-L1 adipocytes has no effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipocyte complement related protein of 30 kD (ACRP30) is markedly enhanced. Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme. Thus, 3T3-L1 adipocytes possess a regulated secretory compartment containing ACRP30. Whether GLUT4 recycles to such a compartment has been controversial. We present deconvolution immunofluorescence microscopy data demonstrating that the subcellular distributions of ACRP30 and GLUT4 are distinct and nonoverlapping; in contrast, those of GLUT4 and the transferrin receptor overlap. Together with supporting evidence that GLUT4 does not recycle to a secretory compartment via the trans-Golgi network, we conclude that there are at least two compartments that undergo insulin-stimulated exocytosis in 3T3-L1 adipocytes: one for ACRP30 secretion and one for GLUT4 translocation.  (+info)

(4/69) Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin.

The AP-1 adaptor complex is associated with the TGN, where it links selected membrane proteins to the clathrin lattice, enabling these proteins to be concentrated in clathrin-coated vesicles. To identify other proteins that participate in the clathrin-coated vesicle cycle at the TGN, we have carried out a yeast two- hybrid library screen using the gamma-adaptin subunit of the AP-1 complex as bait. Two novel, ubiquitously expressed proteins were found: p34, which interacts with both gamma-adaptin and alpha-adaptin, and gamma-synergin, an alternatively spliced protein with an apparent molecular mass of approximately 110-190 kD, which only interacts with gamma-adaptin. gamma-Synergin is associated with AP-1 both in the cytosol and on TGN membranes, and it is strongly enriched in clathrin-coated vesicles. It binds directly to the ear domain of gamma-adaptin and it contains an Eps15 homology (EH) domain, although the EH domain is not part of the gamma-adaptin binding site. In cells expressing alpha-adaptin with the gamma-adaptin ear, a construct that goes mainly to the plasma membrane, much of the gamma-synergin is also rerouted to the plasma membrane, indicating that it follows AP-1 onto membranes rather than leading it there. The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins.  (+info)

(5/69) Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains.

The molecular basis of the selectivity and the details of the vesicle formation in endocytic and secretory pathways are still poorly known and most probably involve as yet unidentified components. Here we describe the cloning, expression, and tissue and cell distribution of a novel protein of 67 kDa (called Vear) that bears homology to several endocytosis-associated proteins in that it has a VHS domain in its N terminus. It is also similar to gamma-adaptin, the heavy subunit of AP-1, in having in its C terminus a typical "ear" domain. In immunofluorescence microscopy, Vear was seen in the Golgi complex as judged by a typical distribution pattern, a distinct colocalization with the Golgi marker gamma-adaptin, and a sensitivity to treatment of cells with brefeldin A. In cell fractionation, Vear partitioned with the post-nuclear membrane fraction. In transfection experiments, hemagglutinin-tagged full-length Vear and truncated Vear lacking the VHS domain assembled on and caused compaction of the Golgi complex. Golgi association without compaction was seen with the ear domain of Vear, whereas the VHS domain alone showed a diffuse membrane- and vesicle-associated distribution. The Golgi association and the bipartite structure along with the differential targeting of its domains suggest that Vear is involved in heterotypic vesicle/suborganelle interactions associated with the Golgi complex. Tissue-specific function of Vear is suggested by its high level of expression in kidney, muscle, and heart.  (+info)

(6/69) A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.

We have cloned and characterized members of a novel family of proteins, the GGAs. These proteins contain an NH(2)-terminal VHS domain, one or two coiled-coil domains, and a COOH-terminal domain homologous to the COOH-terminal "ear" domain of gamma-adaptin. However, unlike gamma-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes. Immunogold EM shows that these membranes correspond to trans elements of the Golgi stack and the TGN. GST pulldown experiments indicate that the GGA COOH-terminal domains bind to a subset of the proteins that bind to the gamma-adaptin COOH-terminal domain. In yeast there are two GGA genes. Deleting both of these genes results in missorting of the vacuolar enzyme carboxypeptidase Y, and the cells also have a defective vacuolar morphology phenotype. These results indicate that the function of the GGAs is to facilitate the trafficking of proteins between the TGN and the vacuole, or its mammalian equivalent, the lysosome.  (+info)

(7/69) GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.

Formation of intracellular transport intermediates and selection of cargo molecules are mediated by protein coats associated with the cytosolic face of membranes. Here, we describe a novel family of ubiquitous coat proteins termed GGAs, which includes three members in humans and two in yeast. GGAs have a modular structure consisting of a VHS domain, a region of homology termed GAT, a linker segment, and a region with homology to the ear domain of gamma-adaptins. Immunofluorescence microscopy showed colocalization of GGAs with Golgi markers, whereas immunoelectron microscopy of GGA3 revealed its presence on coated vesicles and buds in the area of the TGN. Treatment with brefeldin A or overexpression of dominant-negative ADP ribosylation factor 1 (ARF1) caused dissociation of GGAs from membranes. The GAT region of GGA3 was found to: target a reporter protein to the Golgi complex; induce dissociation from membranes of ARF-regulated coats such as AP-1, AP-3, AP-4, and COPI upon overexpression; and interact with activated ARF1. Disruption of both GGA genes in yeast resulted in impaired trafficking of carboxypeptidase Y to the vacuole. These observations suggest that GGAs are components of ARF-regulated coats that mediate protein trafficking at the TGN.  (+info)

(8/69) Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells.

Expression of the epithelial cell-specific heterotetrameric adaptor complex AP-1B is required for the polarized distribution of many membrane proteins to the basolateral surface of LLC-PK1 kidney cells. AP-1B is distinguished from the ubiquitously expressed AP-1A by exchange of its single 50-kD mu subunit, mu1A, being replaced by the closely related mu1B. Here we show that this substitution is sufficient to couple basolateral plasma membrane proteins, such as a low-density lipoprotein receptor (LDLR), to the AP-1B complex and to clathrin. The interaction between LDLR and AP-1B is likely to occur in the trans-Golgi network (TGN), as was suggested by the localization of functional, epitope-tagged mu1 by immunofluorescence and immunoelectron microscopy. Tagged AP-1A and AP-1B complexes were found in the perinuclear region close to the Golgi complex and recycling endosomes, often in clathrin-coated buds and vesicles. Yet, AP-1A and AP-1B localized to different subdomains of the TGN, with only AP-1A colocalizing with furin, a membrane protein that uses AP-1 to recycle between the TGN and endosomes. We conclude that AP-1B functions by interacting with its cargo molecules and clathrin in the TGN, where it acts to sort basolateral proteins from proteins destined for the apical surface and from those selected by AP-1A for transport to endosomes and lysosomes.  (+info)

*  AP1G2
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ... and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, ...
*  AP1G1
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ...
*  Sec61 alpha 1
... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... contains beta and gamma subunits. GRCh38: Ensembl release 89: ENSG00000058262 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
*  Synergin gamma
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located ... Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. ...
*  Clathrin adaptor protein
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Gamma-adaptin ear homology, ARF-binding proteins) adaptors. Adaptins are distantly related to the other main type of vesicular ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
*  Vesicular transport adaptor protein
The other large protein has different designations in the different complexes. In AP-1 it is named γ (gamma), AP-2 has α (alpha ... The two smaller proteins are a medium subunit named μ (mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ...
*  AP1S1
"Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit". Montpetit A, Côté S, Brustein E, Drouin CA, Lapointe L ... This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein ... AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. The protein encoded by this gene is ... Boehm M, Aguilar RC, Bonifacino JS (Nov 2001). "Functional and physical interactions of the adaptor protein complex AP-4 with ...
*  AP1M1
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
*  B2-adapt-app C
Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors. AP (adaptor protein) complexes are found in coated vesicles ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
*  Chromosome 20 (human)
... encoding protein cAMP-dependent protein kinase inhibitor gamma PLAGL2: encoding protein Zinc finger protein PLAGL2 POLR3F: ... encoding protein Kizuna centrosomal protein Kua-UEV: LIME1: encoding protein Lck-interacting transmembrane adapter 1 LZTS3: ... Glucocorticoid modulatory element-binding protein 2 GNAS1: Gs alpha subunit (membrane G-protein) GSS: glutathione synthetase ... encoding enzyme Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog VAPB: VAMP (vesicle-associated membrane protein ...
*  ABL (gene)
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ...
*  Interferon gamma
IFNγ suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, ... sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex ... including subunits of the immunoproteasome (MECL1, LMP2, LMP7), as well as TAP and ERAAP in addition possibly to the direct ... "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex". ...
*  CRKL
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ...
*  Naive T cell
... associated protein Zap70 activated Zap70 in turn phosphorylates the membrane adaptor Lat, which subsequently recruits several ... In the naïve state, T cells are thought to be quiescent and non-dividing, requiring the common-gamma chain cytokines IL-7 and ... They also express functional IL-7 receptors, consisting of subunits IL-7 receptor-α, CD127, and common-γ chain, CD132. ... which results in phosphorylation of the CD3 coreceptor complex and ζ-chains of the TCR and activation of the ζ-chain- ...
*  GAB2
... domain that is contained in the adaptor protein families Crk, Grb2, and Nck. These adaptor proteins then couple to enzymes to ... An activated complex of GAB2, SHC, and SHP2 is required for binding of Phospholipase C gamma 2 (PLCG2) through its SH2 domain, ... The p85 subunit of PI3K (or PIK3) possessed the SH2 domain required to be activated by GAB2. The activation of the PI3K ... GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking ...
*  TRA (gene)
2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an ... "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299- ... CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a ... T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or [email protected] It contributes ...
*  List of A1 genes, proteins or receptors
... alpha 1 Adaptor-related protein complex 2, alpha 1 Aldehyde dehydrogenase 3 family, member A1 Aldehyde dehydrogenase 4 family, ... subunit, alpha 1 Protein kinase, AMP-activated, alpha 1 Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), ... member A1 Gamma-aminobutyric acid (GABA) A receptor, alpha 1 Gap junction protein, alpha 1 GDNF family receptor alpha 1 ... alpha 1 RNA binding motif protein, Y-linked, family 1, member A1 Replication protein A1 S100 calcium binding protein A1 Sec61 ...
*  GNB1
"Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits ... including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765-71. doi: ...
*  GRB2
"SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and ... "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (Mar 1994). "A complex of Grb2 adaptor protein, Sos exchange ...
*  Lymphocyte cytosolic protein 2
"The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ... "Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking". Blood. 88 (2): 522-30. ... Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells ... with the p85 subunit of phosphoinositide 3-kinase". FEBS Lett. 575 (1-3): 35-40. doi:10.1016/j.febslet.2004.07.090. PMID ...
*  Fc receptor
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. The Fc-gamma receptors differ ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... For example, those that bind the most common class of antibody, IgG, are called Fc-gamma receptors (FcγR), those that bind IgA ...
*  COPG2
"Entrez Gene: COPG2 coatomer protein complex, subunit gamma 2". Bermak JC, Li M, Bullock C, Weingarten P, Zhou QY (Feb 2002). " ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... Coatomer subunit gamma-2 is a protein that in humans is encoded by the COPG2 gene. COPG2 has been shown to interact with ...
*  FCER1A
The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated. GRCh38 ... 2002). "Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells". ... 1996). "Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI ... Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for ...
*  AP1B1
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. Adaptor protein complex 1 is found at the ... Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in ... "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; ... The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein ...
*  PRKAB1
1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in ... This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. Model organisms have been ... 5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene. The protein encoded ... 1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". J. Biol. Chem. 271 (15): 8675- ...
*  MYD88
In that species it is a universal adapter protein as it is used by almost all TLRs (except TLR 3) to activate the transcription ... Jefferies C, Bowie A, Brady G, Cooke EL, Li X, O'Neill LA (Jul 2001). "Transactivation by the p65 subunit of NF-kappaB in ... fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up- ... "Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in ...
Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits  Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits
Adaptor-Related Protein Complex 1, mu 1 Subunit ELISA Kits * Adaptor-Related Protein Complex 1, gamma 1 Subunit ELISA Kits ... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... adaptor related protein complex 2 mu 1 subunit (AP2M1) Elisa Kit * adaptor-related protein complex 2, mu 1 subunit, a (ap2m1a) ... adaptor-related protein complex 2, mu 1 subunit (Ap2m1) Elisa Kit * adaptor related protein complex 2 mu 1 subunit L homeolog ( ...
more infohttp://www.antikoerper-online.de/egfr-signaling-pathway-pathway-26/ap2m1-elisa-kit-1886/
Ap1g1 adaptor protein complex AP-1, gamma 1 subunit [Mus musculus (house mouse)] - Gene - NCBI  Ap1g1 adaptor protein complex AP-1, gamma 1 subunit [Mus musculus (house mouse)] - Gene - NCBI
AP-1 complex subunit gamma-1. Names. adapter-related protein complex 1 subunit gamma-1. adaptor protein complex AP-1 subunit ... Ap1g1 adaptor protein complex AP-1, gamma 1 subunit [Mus musculus] Ap1g1 adaptor protein complex AP-1, gamma 1 subunit [Mus ... adaptor-related protein complex 1 subunit gamma-1. clathrin assembly protein complex 1 gamma-1 large chain. gamma-adaptin. ... adaptor protein complex AP-1, gamma 1 subunitprovided by MGI. Primary source. MGI:MGI:101919 See related. Ensembl: ...
more infohttps://www.ncbi.nlm.nih.gov/gene/?term=11765
Ap1g1 - adaptor protein complex AP-1, gamma 1 subunit | International Mouse Phenotyping Consortium  Ap1g1 - adaptor protein complex AP-1, gamma 1 subunit | International Mouse Phenotyping Consortium
Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ap1g1 data for that phenotype. ...
more infohttps://www.mousephenotype.org/data/genes/MGI:101919
adaptor related protein complex 1 subunit gamma 2 ELISA Kits from MyBioSource.com | Biocompare.com  adaptor related protein complex 1 subunit gamma 2 ELISA Kits from MyBioSource.com | Biocompare.com
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more infohttps://www.biocompare.com/pfu/110627/soids/2-2271930/ELISA_Kit/ELISA_adaptor_related_protein_complex_1_gamma_2_subunit?vids=104355
AP1G2 Gene - GeneCards | AP1G2 Protein | AP1G2 Antibody  AP1G2 Gene - GeneCards | AP1G2 Protein | AP1G2 Antibody
Protein Coding), Adaptor Related Protein Complex 1 Subunit Gamma 2, including: function, proteins, disorders, pathways, ... The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... AP1G2 (Adaptor Related Protein Complex 1 Subunit Gamma 2) is a Protein Coding gene. Diseases associated with AP1G2 include Long ... AP1G2 Gene(Protein Coding) Adaptor Related Protein Complex 1 Subunit Gamma 2. ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=AP1G2
AP1G1 - AP-1 complex subunit gamma-1 - Homo sapiens (Human) - AP1G1 gene & protein  AP1G1 - AP-1 complex subunit gamma-1 - Homo sapiens (Human) - AP1G1 gene & protein
The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the ... Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi ... Subunit structurei. Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit ... Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi ...
more infohttp://www.uniprot.org/uniprot/O43747
Produktübersicht anti-gamma 1 Adaptin Antikörper  Produktübersicht anti-gamma 1 Adaptin Antikörper
Ausgesuchte Qualitäts-Hersteller für gamma 1 Adaptin Antikörper. Hier bestellen. ... Monoklonale und polyklonale gamma 1 Adaptin Antikörper für viele Methoden. ... AP-1 complex subunit gamma-1 , adapter-related protein complex 1 subunit gamma-1 , adaptor protein complex AP-1 subunit gamma-1 ... gamma 1 , gamma adaptin , golgi adaptor HA1/AP1 adaptin gamma subunit , adaptor protein complex AP-1 gamma 1 subunit , adaptor ...
more infohttp://www.antikoerper-online.de/abstract/AdaptorRelated+Protein+Complex+1%2C+gamma+1+Subunit+
Kinetics of B-fragment transport from EE/RE to the Golg | Open-i  Kinetics of B-fragment transport from EE/RE to the Golg | Open-i
Adaptor Protein Complex gamma Subunits. *Biological Transport/drug effects/physiology. *Brefeldin A/pharmacology ... and since B-fragment colocalized with adaptor protein type 1 clathrin coat components on early/recycling endosomes. Thus, we ... and since B-fragment colocalized with adaptor protein type 1 clathrin coat components on early/recycling endosomes. Thus, we ... This pathway may also be used by cellular proteins, as deduced from our finding that TGN38 colocalized with the B-fragment on ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2132951_JCB9806018.f3a&req=4
Characterization of  clathrin-coated vesicles isolated  | Open-i  Characterization of clathrin-coated vesicles isolated | Open-i
Adaptor Protein Complex alpha Subunits. *Adaptor Protein Complex gamma Subunits. *Adaptor Proteins, Vesicular Transport ... Adaptor Protein Complex alpha Subunits. *Adaptor Protein Complex gamma Subunits. *Adaptor Proteins, Vesicular Transport ... When analyzed by SDS-PAGE followed by protein staining, the dense fractions exhibited the typical protein profile of purified ... When analyzed by SDS-PAGE followed by protein staining, the dense fractions exhibited the typical protein profile of purified ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2139777_JCB.laborgne6&req=4
anti-gamma Adaptin antibody  | GeneTex  anti-gamma Adaptin antibody | GeneTex
... adaptor-related protein complex 1, gamma 1 subunit) for ELISA, IHC-P, WB. Anti-gamma Adaptin pAb (GTX37788) is tested in Human ... The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... adaptor-related protein complex 1, gamma 1 subunit. Background. Adaptins are important components of clathrin-coated vesicles ... CLAPG1 Antibody , ADTG Antibody , adaptor-related protein complex 1, gamma 1 subunit Antibody , AP1G1 Antibody. ...
more infohttp://www.genetex.com/gamma-Adaptin-antibody-GTX37788.html
AP1G2 Antibody 17907-1-AP  | Proteintech  AP1G2 Antibody 17907-1-AP | Proteintech
AP1G2 fusion protein Ag12300 Full name: adaptor-related protein complex 1, gamma 2 subunit ...
more infohttps://www.ptglab.com/Products/AP1G2-Antibody-17907-1-AP.htm
AP1G2 - Wikipedia  AP1G2 - Wikipedia
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ... and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, ...
more infohttps://en.wikipedia.org/wiki/AP1G2
AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens (human)] - Gene - NCBI  AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens (human)] - Gene - NCBI
PIPKIgamma also interacts with the mu subunits of clathrin adaptor protein (AP) complexes Title: Type I gamma ... adaptor protein complex AP-1 mu-2 subunit. adaptor related protein complex 1 mu 2 subunit. clathrin assembly protein complex 1 ... AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens] AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo ... clathrin-associated adaptor medium chain mu2. golgi adaptor AP-1 47 kDa protein. golgi adaptor HA1/AP1 adaptin mu-2 subunit. mu ...
more infohttps://www.ncbi.nlm.nih.gov/gene/10053
Human AP1G1 ELISA Kit | biobool.com  Human AP1G1 ELISA Kit | biobool.com
Human adaptor protein complex AP-1 subunit gamma-1 ELISA Kit;Human adaptor-related protein complex 1 subunit gamma-1 ELISA Kit; ... Human adaptor related protein complex 1 gamma 1 subunit ELISA Kit;Human AP-1 complex subunit gamma-1 ELISA Kit;Human adapter- ... related protein complex 1 subunit gamma-1 ELISA Kit;Human clathrin assembly protein complex 1 gamma large chain ELISA Kit;Human ... Human gamma adaptin ELISA Kit;Human golgi adaptor HA1/AP1 adaptin gamma subunit ELISA Kit;Human testicular tissue protein Li 21 ...
more infohttps://www.biobool.com/elisa_kit/3159.html
NAVER Academic > Search...  NAVER Academic > Search...
Adaptor Protein Complex 1, metabolism, Adaptor Protein Complex gamma Subunits, genetics, Amino Acid Sequence, Animals, ... Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking.. 2005 Veronika E Neubrand et al. EMBO JOURNAL ... C/EBP homologous protein (CHOP) is a stress-inducible nuclear protein that is crucial for the development of programmed cell ... Bacterial Outer Membrane Proteins, chemistry, metabolism, physiology, Crystallization, Lipoproteins, Protein Conformation, ...
more infohttps://academic.naver.com/search.naver?field=3&query=EMBO+JOURNAL+24%EA%B6%8C+6%ED%98%B8
AP1G1 - Wikipedia  AP1G1 - Wikipedia
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ...
more infohttps://en.wikipedia.org/wiki/AP1G1
Ikbkg - NF-kappa-B essential modulator - Rattus norvegicus (Rat) - Ikbkg gene & protein  Ikbkg - NF-kappa-B essential modulator - Rattus norvegicus (Rat) - Ikbkg gene & protein
... core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex ... probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to ... associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/ ... section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes ...
more infohttps://www.uniprot.org/uniprot/Q6TMG5
IMP: Integrative Multi-species Prediction  IMP: Integrative Multi-species Prediction
adaptor-related protein complex 1, gamma 1 subunit. 0.031. ADIPOR1. adiponectin receptor 1. 0.031. ... adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. 0.287. ... adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. 0.106. ... ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1). 0.011. ...
more infohttp://imp.princeton.edu/predictions/process/human-context-global/3124/?gene=12075
IMP: Integrative Multi-species Prediction  IMP: Integrative Multi-species Prediction
adaptor-related protein complex 1, gamma 1 subunit. 0.010. EMILIN1. elastin microfibril interfacer 1. 0.010. ... inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma. 0.113. ... AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast). 0.018. ... chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2). 0.023. ...
more infohttp://imp.princeton.edu/predictions/process/human-context-global/9585/?gene=11470
RCSB PDB - 3L81: Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting...  RCSB PDB - 3L81: Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting...
... mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP) ... Disruption of the APP-AP-4 interaction decreases localization of APP to endosomes and enhances gamma-secretase-catalyzed ... Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the ... Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.. Burgos, P.V., Mardones, G.A., Rojas ...
more infohttps://www.rcsb.org/structure/3L81
OriGene - SEC61A1 (NM 013336) cDNA Clone  OriGene - SEC61A1 (NM 013336) cDNA Clone
Human Sec61 alpha 1 subunit (S. cerevisiae) (SEC61A1) available for purchase from OriGene - Your Gene Company. ... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... contains beta and gamma subunits. [provided by RefSeq, Jul 2008]. SC115289 has not yet been cited specifically in any ... Lenti ORF clone of Sec61a1 (Myc-DDK-tagged ORF) - Rat Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1), (10 ug). $772. 8 weeks. ...
more infohttp://www.origene.com/cdna/trueclone/accession/NM_013336/SC115289.aspx
Anti-IKKα Antibody | 07-1007  Anti-IKKα Antibody | 07-1007
The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a ... probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. ... The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription ... SUBUNIT STRUCTURE: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; ...
more infohttp://www.merckmillipore.com/IN/en/product/Anti-IKK-Antibody,MM_NF-07-1007?CatalogCategoryID=
The effect of cyclin G associated kinase on androgen receptor function and prostate cancer progression - UBC Library Open...  The effect of cyclin G associated kinase on androgen receptor function and prostate cancer progression - UBC Library Open...
Kametaka demonstrated that GAK interacts with the gamma subunit of AP1, the adaptor protein complex that is a heterotetramer ... Veldscholte, J., et al., Hormone-induced dissociation of the androgen receptorheat-shock protein complex: use of a new ... Kametaka, S., et al., Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme ... Adegbola, O. and G.R. Pasternack, A pp32-retinoblastoma protein complex modulates androgen receptor-mediated transcription and ...
more infohttps://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0066927
ELM - Detail for LIG AP GAE 1  ELM - Detail for LIG AP GAE 1
AP-1 heterotetrameric complex contains a gamma-adaptin subunit bearing a gamma-ear at its carboxy terminus, while Ggas are ... The Gamma-ear interaction motif interacts with gamma-ear domains of adaptor proteins involved in clathrin coated vesicles ... By analogy with AP-2 (the well characterized adaptor complex involved in endocytic CCV formation) the gamma-ear domain of AP-1 ... Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif.. Duncan MC, ...
more infohttp://elm.eu.org/elms/LIG_AP_GAE_1
  • GAB2 along with many other adaptor, scaffold, and docking proteins, was discovered in the mid-1990s during the isolation and cloning of protein tyrosine kinase substrates and association partners. (wikipedia.org)
  • A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. (wikipedia.org)
  • Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9. (wikipedia.org)
  • Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. (wikipedia.org)
  • alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene. (wikipedia.org)
  • Folding of the β-subunit is thought to be aided by the chaperone CCT (chaperonin containing tailless-complex polypeptide 1), which also prevents aggregation of folded subunits. (wikipedia.org)
  • By binding to the p85 subunit of PI3K, and continuing this signaling pathway GAB provides positive feedback for the creation of PIP3, produced as a result of the PI3K pathway, which binds to GAB2 in the membrane and promotes activation of more PI3Ks. (wikipedia.org)
  • Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. (wikipedia.org)
  • The C-terminal SH3 domain binds to peptides conforming to a P-X-I/L/V/-D/N-R-X-X-K-P motif that allows it to specifically bind to proteins such as Gab-1. (wikipedia.org)
  • a specific site of the protein that binds to diverse range of peptides and is thought to be a contributing factor in the ability of Gβγ to interact with a wide variety of effectors. (wikipedia.org)
  • A second chaperone, PhLP (phosducin-like protein), binds to the CCT/Gβ complex, and is phosphorylated, allowing CCT to dissociate and Gγ to bind. (wikipedia.org)
  • The WASp binds to the SH3 domains within the N-terminus of the protein and after Nck1 has been activated by the signal from the ligand binding to a receptor tyrosine kinase and then uses the WASp/Arp2/3 complex to reorganize the actin cytoskeleton and cause the polarization of the cell as well as promote directional migration via pseudopodia. (wikipedia.org)
  • These proteins are synthesized in the ribosomes, processed in the endoplasmic reticulum and transported from the Golgi apparatus to the trans-Golgi network, and from there via small carrier vesicles to their final destination compartment. (wikipedia.org)
  • They mediate binding events that control the activity and localization of many proteins involved in the transmission of signals from the cell surface to the nucleus. (wikipedia.org)
  • GAB1, GAB2, GAB3 and GAB4) GAB2 is an Intrinsically disordered protein, meaning that beyond the folded N-terminal region, the C-terminal region extends out into the cytoplasm with little or no secondary structure. (wikipedia.org)
  • The motif is also found in vacuole sorting proteins in yeast (Vps3p and Vps72p), in ENTH containing (uncharacterized) S.pombe and C.elegans proteins, in gamma-synergin and in Rabaptin 5 (human, mouse and rat). (eu.org)
  • Shortly after, the Gβγ complex associated with a mating factor receptor-coupled G protein in yeast was found to initiate a pheromone response. (wikipedia.org)
  • It is on the C-terminal tail that the various conserved protein binding motifs and phosphorylation sites of GAB2 are found. (wikipedia.org)
  • The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. (wikipedia.org)
  • This renewed glucose tolerance and insulin signaling is caused by the inhibition of the unfolded protein response pathway, particularly the protein IRE1alpha, and its subsequent phosphorylation of IRS-1 that causes insulin signaling to be blocked. (wikipedia.org)