A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.
An adaptor protein complex found primarily on perinuclear compartments.
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.
An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.
The subunits that make up the large, medium and small chains of adaptor proteins.
A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.
A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.
A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.
The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)
A subclass of clathrin assembly proteins that occur as monomers.
Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.
Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)
Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.
Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.
Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A plant genus of the family CUCURBITACEAE known for the edible fruit.
A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
Individuals licensed to practice medicine.
A publication issued at stated, more or less regular, intervals.
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A heat stable DNA-DIRECTED DNA POLYMERASE from the bacteria Thermus aquaticus. It is widely used for the amplification of genes through the process of POLYMERASE CHAIN REACTION. EC 2.7.7.-.
Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.

Early embryonic death of mice deficient in gamma-adaptin. (1/69)

Intracellular protein transport and sorting by vesicles in the secretory and endocytic pathways requires the formation of a protein coat on the membrane. The heterotetrameric adaptor protein complex 1 (AP-1) promotes the formation of clathrin-coated vesicles at the trans-Golgi network. AP-1 interacts with various sorting signals in the cytoplasmic tails of cargo molecules, thus indicating a function in protein sorting. We generated mutants of the gamma-adaptin subunit of AP-1 in mice to investigate its role in post-Golgi vesicle transport and sorting processes. gamma-Adaptin-deficient embryos develop until day 3.5 post coitus and die during the prenidation period, revealing that AP-1 is essential for viability. In heterozygous mice the amount of AP-1 complexes is reduced to half of controls. Free beta1- or micro1 chains were not detectable, indicating that they are unstable unless they are part of AP-1 complexes. Heterozygous mice weigh less then their wild-type littermates and show impaired T cell development.  (+info)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (2/69)

We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1 and 3 positions of the 2-deoxystreptamine moiety of the antibiotics. These two amines appear to mimic the epsilon-amino groups present in the two lysine residues of the KKXX motif that is known to bind coatomer. Here we report the effects of 1, 3-cyclohexanebis(methylamine) (CBM) on secretion in vivo, a compound chosen for study because it contains primary amino groups that resemble those in 2-deoxystreptamine and it should penetrate lipid bilayers more readily than antibiotics. CBM inhibited coatomer binding to Golgi membranes in vitro and in vivo and inhibited secretion by intact cells. Despite depressed binding of coatomer in vivo, the Golgi complex retained its characteristic perinuclear location in the presence of CBM and did not fuse with the endoplasmic reticulum (ER). Transport from the ER to the Golgi was also not blocked by CBM. These data suggest that a full complement of coat protein I (COPI) on membranes is not critical for maintenance of Golgi integrity or for traffic from the ER to the Golgi but is necessary for transport through the Golgi to the plasma membrane.  (+info)

Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. (3/69)

Insulin stimulates adipose cells both to secrete proteins and to translocate the GLUT4 glucose transporter from an intracellular compartment to the plasma membrane. We demonstrate that whereas insulin stimulation of 3T3-L1 adipocytes has no effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipocyte complement related protein of 30 kD (ACRP30) is markedly enhanced. Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme. Thus, 3T3-L1 adipocytes possess a regulated secretory compartment containing ACRP30. Whether GLUT4 recycles to such a compartment has been controversial. We present deconvolution immunofluorescence microscopy data demonstrating that the subcellular distributions of ACRP30 and GLUT4 are distinct and nonoverlapping; in contrast, those of GLUT4 and the transferrin receptor overlap. Together with supporting evidence that GLUT4 does not recycle to a secretory compartment via the trans-Golgi network, we conclude that there are at least two compartments that undergo insulin-stimulated exocytosis in 3T3-L1 adipocytes: one for ACRP30 secretion and one for GLUT4 translocation.  (+info)

Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. (4/69)

The AP-1 adaptor complex is associated with the TGN, where it links selected membrane proteins to the clathrin lattice, enabling these proteins to be concentrated in clathrin-coated vesicles. To identify other proteins that participate in the clathrin-coated vesicle cycle at the TGN, we have carried out a yeast two- hybrid library screen using the gamma-adaptin subunit of the AP-1 complex as bait. Two novel, ubiquitously expressed proteins were found: p34, which interacts with both gamma-adaptin and alpha-adaptin, and gamma-synergin, an alternatively spliced protein with an apparent molecular mass of approximately 110-190 kD, which only interacts with gamma-adaptin. gamma-Synergin is associated with AP-1 both in the cytosol and on TGN membranes, and it is strongly enriched in clathrin-coated vesicles. It binds directly to the ear domain of gamma-adaptin and it contains an Eps15 homology (EH) domain, although the EH domain is not part of the gamma-adaptin binding site. In cells expressing alpha-adaptin with the gamma-adaptin ear, a construct that goes mainly to the plasma membrane, much of the gamma-synergin is also rerouted to the plasma membrane, indicating that it follows AP-1 onto membranes rather than leading it there. The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins.  (+info)

Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains. (5/69)

The molecular basis of the selectivity and the details of the vesicle formation in endocytic and secretory pathways are still poorly known and most probably involve as yet unidentified components. Here we describe the cloning, expression, and tissue and cell distribution of a novel protein of 67 kDa (called Vear) that bears homology to several endocytosis-associated proteins in that it has a VHS domain in its N terminus. It is also similar to gamma-adaptin, the heavy subunit of AP-1, in having in its C terminus a typical "ear" domain. In immunofluorescence microscopy, Vear was seen in the Golgi complex as judged by a typical distribution pattern, a distinct colocalization with the Golgi marker gamma-adaptin, and a sensitivity to treatment of cells with brefeldin A. In cell fractionation, Vear partitioned with the post-nuclear membrane fraction. In transfection experiments, hemagglutinin-tagged full-length Vear and truncated Vear lacking the VHS domain assembled on and caused compaction of the Golgi complex. Golgi association without compaction was seen with the ear domain of Vear, whereas the VHS domain alone showed a diffuse membrane- and vesicle-associated distribution. The Golgi association and the bipartite structure along with the differential targeting of its domains suggest that Vear is involved in heterotypic vesicle/suborganelle interactions associated with the Golgi complex. Tissue-specific function of Vear is suggested by its high level of expression in kidney, muscle, and heart.  (+info)

A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. (6/69)

We have cloned and characterized members of a novel family of proteins, the GGAs. These proteins contain an NH(2)-terminal VHS domain, one or two coiled-coil domains, and a COOH-terminal domain homologous to the COOH-terminal "ear" domain of gamma-adaptin. However, unlike gamma-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes. Immunogold EM shows that these membranes correspond to trans elements of the Golgi stack and the TGN. GST pulldown experiments indicate that the GGA COOH-terminal domains bind to a subset of the proteins that bind to the gamma-adaptin COOH-terminal domain. In yeast there are two GGA genes. Deleting both of these genes results in missorting of the vacuolar enzyme carboxypeptidase Y, and the cells also have a defective vacuolar morphology phenotype. These results indicate that the function of the GGAs is to facilitate the trafficking of proteins between the TGN and the vacuole, or its mammalian equivalent, the lysosome.  (+info)

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. (7/69)

Formation of intracellular transport intermediates and selection of cargo molecules are mediated by protein coats associated with the cytosolic face of membranes. Here, we describe a novel family of ubiquitous coat proteins termed GGAs, which includes three members in humans and two in yeast. GGAs have a modular structure consisting of a VHS domain, a region of homology termed GAT, a linker segment, and a region with homology to the ear domain of gamma-adaptins. Immunofluorescence microscopy showed colocalization of GGAs with Golgi markers, whereas immunoelectron microscopy of GGA3 revealed its presence on coated vesicles and buds in the area of the TGN. Treatment with brefeldin A or overexpression of dominant-negative ADP ribosylation factor 1 (ARF1) caused dissociation of GGAs from membranes. The GAT region of GGA3 was found to: target a reporter protein to the Golgi complex; induce dissociation from membranes of ARF-regulated coats such as AP-1, AP-3, AP-4, and COPI upon overexpression; and interact with activated ARF1. Disruption of both GGA genes in yeast resulted in impaired trafficking of carboxypeptidase Y to the vacuole. These observations suggest that GGAs are components of ARF-regulated coats that mediate protein trafficking at the TGN.  (+info)

Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells. (8/69)

Expression of the epithelial cell-specific heterotetrameric adaptor complex AP-1B is required for the polarized distribution of many membrane proteins to the basolateral surface of LLC-PK1 kidney cells. AP-1B is distinguished from the ubiquitously expressed AP-1A by exchange of its single 50-kD mu subunit, mu1A, being replaced by the closely related mu1B. Here we show that this substitution is sufficient to couple basolateral plasma membrane proteins, such as a low-density lipoprotein receptor (LDLR), to the AP-1B complex and to clathrin. The interaction between LDLR and AP-1B is likely to occur in the trans-Golgi network (TGN), as was suggested by the localization of functional, epitope-tagged mu1 by immunofluorescence and immunoelectron microscopy. Tagged AP-1A and AP-1B complexes were found in the perinuclear region close to the Golgi complex and recycling endosomes, often in clathrin-coated buds and vesicles. Yet, AP-1A and AP-1B localized to different subdomains of the TGN, with only AP-1A colocalizing with furin, a membrane protein that uses AP-1 to recycle between the TGN and endosomes. We conclude that AP-1B functions by interacting with its cargo molecules and clathrin in the TGN, where it acts to sort basolateral proteins from proteins destined for the apical surface and from those selected by AP-1A for transport to endosomes and lysosomes.  (+info)

Genetic information processingProtein fateProtein and peptide secretion and traffickingprotein translocase SEC61 complex gamma subunit, archaeal and eukaryotic (TIGR00327; HMM-score: 8.1) ...
Warner Bros. announced today the release dates of two high-profile film adaptations, the Clint Eastwood-directed Jersey Boys and Ben Afflecks Live By Night.
Bedste ⭐ 31 grunde for Sony SRS-X77 vs Clint Freya: 1. højde 2. bredte 3. kontrolpanelet sidder på selve enheden 4. har indbygget stereo højtaler 5. vægt 6. volume
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Clint M. Kraus, D.O. is a specialist in Family Medicine who has an office at 940 Northgate Drive in Richland, WA and can be reached at (509) 942-2516.
Read movie and film review for Blood Work (2002) - Clint Eastwood on AllMovie - When the deconstructive Western Unforgiven…
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
Reaktivität: Huhn, Rind (Kuh), Hund and more. 17 verschiedene AP2M1 ELISA Kits vergleichen. Alle direkt auf antikoerper-online.de bestellbar!
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
The structure of the appendage domain of β2 adaptin is similar to that of α‐adaptin in that it has two subdomains with similar topology, but with a difference of ∼46° in the orientation between the two subdomains. Like the α‐appendage, the β2‐appendage domain binds AP180, epsin and eps15, and therefore is likely to be involved in recruiting proteins involved in controlling CCV formation to sites of coated pit formation in vivo. The two proteins possess a partly conserved binding site of high hydrophobic potential on the C‐terminal platform domain, suggesting that they bind similar motifs i.e. DΦF/W. The binding site residues are also conserved in β1‐adaptin from the adaptor AP1, so this homologue would be predicted to bind the same ligands as β2. Indeed, a GSTβ1 appendage construct does bind to eps15, and weakly to clathrin and epsin (data not shown). Although the α and β2 appendages share some of the same ligands, they bind to them with different relative affinities: the ...
A Sandwich ELISA, Double Antibody ELISA kit for the detection of Rattus norvegicus, Rat, AP-1 complex subunit mu-1, AP-mu chain family member mu1A, Adaptor protein complex AP-1 mu-1 subunit, Adaptor-related protein complex 1 mu-1 subunit, Clathrin assembl
AP4M1 antibody [N1C1] (adaptor-related protein complex 4, mu 1 subunit) for IHC-P, WB. Anti-AP4M1 pAb (GTX115196) is tested in Human, Mouse samples. 100% Ab-Assurance.
AP3S1 antibody (adaptor-related protein complex 3, sigma 1 subunit) for ELISA, ICC/IF, IHC-P, WB. Anti-AP3S1 pAb (GTX31839) is tested in Human, Mouse samples. 100% Ab-Assurance.
VHS domains are found at the N-termini of select proteins involved inintracellular membrane trafficking. We have determined the crystalstructure of the VHS domain of the human Tom1 (target of myb 1) protein to1.5 A resolution. The domain consists of eight helices arranged in asuperhelix. The surface of the domain has two main features: (1) a basicpatch on one side due to several conserved positively charged residues onhelix 3 and (2) a negatively charged ridge on the opposite side, formed byresidues on helix 2. We compare our structure to the recently obtainedstructure of tandem VHS-FYVE domains from Hrs [Mao, Y., Nickitenko, A.,Duan, X., Lloyd, T. E., Wu, M. N., Bellen, H., and Quiocho, F. A. (2000)Cell 100, 447-456]. Key features of the interaction surface between theFYVE and VHS domains of Hrs, involving helices 2 and 4 of the VHS domain,are conserved in the VHS domain of Tom1, even though Tom1 does not have aFYVE domain. We also compare the structures of the VHS domains of Tom1 andHrs to the ...
Analyses with the yeast two-hybrid system showed that the cytosolic tail of the human CI-MPR interacted with full-length GGA3 as well as with the ∼150-amino acid VHS domain, but not the GAT or GAE domains of GGA3 (Fig. 1C). Further analyses revealed that the CI-MPR tail interacted with the VHS domains of all three GGAs and that the CD-MPR tail interacted with the VHS domains of GGA1 and, more weakly, GGA3 (Fig. 1D). These interactions were highly specific, because neither MPR tail bound to the VHS domains of STAM1, HRS, TOM1, and TOM1L1 (Fig. 1D). Likewise, we did not detect interactions between the GGA VHS domains and the cytosolic tails of TGN38, TRP2, tyrosinase, TRP1, LAMP-2, LIMP II, low density lipoprotein (LDL) receptor, β-amyloid precursor, and transferrin receptor (Fig. 1D), which contain either tyrosine-based sorting signals or dileucine-based sorting signals devoid of acidic clusters.. Deletion of the acidic-cluster-dileucine signals from the CI-MPR and CD-MPR tails abolished ...
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I found Clint in my front yard. He was starving and had scabies. I named him Clint for Clint Eastwood because hes tough! He is the sweetest cat. I took him to the vet and he is doing great! He has gained over a pound and he is adorable.. ...
Calories in Clint & Sons Black Label Beef Jerky. Find nutrition facts for Clint & Sons Black Label Beef Jerky and over 2,000,000 other foods in MyFitnessPal.coms food database.
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
reference: Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains., Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH, Nature 2002 Feb 21;415(6874):933-7. PMID: 11859375 ...
How do you define health? Physical? Mental? Social? Health goes beyond medical care. Its how we take care of ourselves, how we interact with our communities, how we take care of each other ...
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2016 ...
The calcium-sensing receptor (CASR) is the main calcium sensor in the maintenance of calcium metabolism. Mutations of the CASR, the G protein alpha 11 (GNA11) and the adaptor-related protein complex 2 sigma 1 subunit (AP2S1) genes can shift the set point for calcium sensing causing hyper- or hypo-calcemic disorders. Therapeutic concepts for these rare diseases range from general therapies of hyper- and hypo-calcemic conditions to more pathophysiology oriented approaches such as parathyroid hormone (PTH) substitution and allosteric CASR modulators. Cinacalcet is a calcimimetic that enhances receptor function and has gained approval for the treatment of hyperparathyroidism. Calcilytics in turn attenuate CASR activity and are currently under investigation for the treatment of various diseases. We conducted a literature search for reports about treatment of patients harboring inactivating or activating CASR, GNA11 or AP2S1 mutants and about in vitro effects of allosteric CASR modulators on mutated ...
EpsinR is a clathrin-coated vesicle (CCV) enriched 70-kD protein that binds to phosphatidylinositol-4-phosphate, clathrin, and the gamma appendage domain of the adaptor protein complex 1 (AP1). In cells, its distribution overlaps with the perinuclear pool of clathrin and AP1 adaptors. Overexpression disrupts the CCV-dependent trafficking of cathepsin D from the trans-Golgi network to lysosomes and the incorporation of mannose-6-phosphate receptors into CCVs. These biochemical and cell biological data point to a role for epsinR in AP1/clathrin budding events in the cell, just as epsin1 is involved in the budding of AP2 CCVs. Furthermore, we show that two gamma appendage domains can simultaneously bind to epsinR with affinities of 0.7 and 45 microM, respectively. Thus, potentially, two AP1 complexes can bind to one epsinR. This high affinity binding allowed us to identify a consensus binding motif of the form DFxDF, which we also find in gamma-synergin and use to predict that an uncharacterized EF-hand
Human gamma-adaptin-related protein 2 ELISA Kit;Human golgi-localized, gamma ear-containing, ARF-binding protein 2 ELISA Kit;Human VHS domain and ear domain of gamma-adaptin ELISA Kit;Human VEAR ELISA Kit;Human KIAA1080 ELISA Kit;Human golgi associated, gamma adaptin ear containing, ARF binding protein 2 ELISA Kit;Human ADP-ribosylation factor-binding protein GGA2 ELISA Kit;Human VHS domain and ear domain-containing protein ELISA Kit ...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Arsenic atom in PDB 1r4x: Crystal Structure Analys of the Gamma-Copi Appendage Domain
Geoffrey Lewis, a prolific character actor who appeared opposite frequent collaborator Clint Eastwood in several movies, has died. He was 79.
I have been hearing more and more these days about groups moving to the unconference model. An unconference has no speakers and attendees only participants. Dave Winer coined this term and this idea in 1998 (See his definition here or Doc Searls here). His fundamental principal is: The sum of the expertise of the people…
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Human 100 kDa coated vesicle protein A ELISA Kit;Human adaptor protein complex AP-2 subunit alpha-1 ELISA Kit;Human adaptor-related protein complex 2 subunit alpha-1 ELISA Kit;Human alpha-adaptin A ELISA Kit;Human alpha1-adaptin ELISA Kit;Human clathrin assembly protein complex 2 alpha-A large chain ELISA Kit;Human plasma membrane adaptor HA2/AP2 adaptin alpha A subunit ELISA Kit;Human ADTAA ELISA Kit;Human CLAPA1 ELISA Kit;Human AP2-ALPHA ELISA Kit;Human adaptor related protein complex 2 alpha 1 subunit ELISA Kit;Human AP-2 complex subunit alpha-1 ELISA Kit;Human adapter-related protein complex 2 alpha-1 subunit ELISA Kit;Human adapter-related protein complex 2 subunit alpha-1 ELISA Kit;Human adaptin, alpha A ELISA Kit;Human clathrin-associated/assembly/adaptor protein, large, alpha 1 ELISA Kit ...
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011 ...
Study VIII - Environmental and Nutritional Diseases flashcards from Clint Benson Valdeavilla's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
On Thursday, October 26th, The Mental Health Association of Westchester welcomed former NHL all-star goalie Clint Malarchuk and his wife Joanie for a riveting and unforgettable evening of conversation.
The Yankees have placed Clint Frazier on the 10-day disabled list with a left oblique strain and have reactivated Aaron Hicks, the team announced. Frazier was penciled into the lineup Wednesday against the Blue Jays but was a late scratch because of the injury. He said hed been experiencing pain over the past few days, but it came to a head during batting practice. Ive been feeling it for a few days, Frazier told reporters Wednesday. It definitely wasnt in BP today. I was feeling some discomfort in my side. Its not any worse. Its maintained its discomfort level. Its just a matter of wanting to make sure everythings all right before I keep going.Ive been telling [the trainers] its been pretty tender the last few days. I think Joe just saw me fiddling with my side in BP today and just wanted to give me a day.. Hicks was placed on the DL in late June with the same injury as Frazier. The outfielder had been on a rehab assignment with Triple-A Scranton and Double-A Trenton, where he ...
Read Matter of Inches by Clint Malarchuk, Dan Robson for free with a 30 day free trial. Read unlimited* books and audiobooks on the web, iPad, iPhone and Android.
If you experience ongoing pain in the area near your ear, your jaw or the muscles on the side of your face, possibly accompanied by a clicking or popping sound
AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene. This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. AP3B1 has been shown to interact with AP3S2. GRCh38: Ensembl release 89: ENSG00000132842 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021686 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. DellAngelica EC, Ooi CE, Bonifacino JS (Jun 1997). Beta3A-adaptin, a subunit of the adaptor-like complex AP-3. The Journal of Biological Chemistry. 272 (24): 15078-84. doi:10.1074/jbc.272.24.15078. PMID 9182526. Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). Characterization of the adaptor-related protein complex, AP-3. The ...
Looking for online definition of Golgi adaptor HA1/AP1 adaptin sigma-1C subunit in the Medical Dictionary? Golgi adaptor HA1/AP1 adaptin sigma-1C subunit explanation free. What is Golgi adaptor HA1/AP1 adaptin sigma-1C subunit? Meaning of Golgi adaptor HA1/AP1 adaptin sigma-1C subunit medical term. What does Golgi adaptor HA1/AP1 adaptin sigma-1C subunit mean?
Kinetics of B-fragment transport from EE/RE to the Golgi apparatus. (A) Confocal microscopy on living HeLa cells. Fluorophore-labeled B-fragment was internalize
Clint Howard, Actor: Apollo 13. Clint Howard also had a recurring role in The Andy Griffith Show, as a little boy always dressed in a cowboy outfit and always eating a peanut butter and jelly sandwich. He never said a word, but was always offering someone a bite. He also had a co-starring role along with a black bear as the owner and friend of Gentle Ben, in that series.
In the first part of this work, LC-MS data were used to calculate the in-vitro intrinsic clearances (CLint) for the metabolism of p-methoxyrnethamphetamine (PMMA) and fluoxetine by the CYP2D6 enzyme using a steady-state (SS) approach and a new general enzyme (GE) screening method. For PMMA, the SS experiment resulted in a CLint of 2.7 ± 0.2 µL pmol 2D6-1min-1 and the GE experiment resulted in a CLint of 3.0 ± 0.6 µL pmol 2D6-1min-1. For fluoxetine, the SS experiment resulted in a CLint of 0.33 ± 0.17 µL pmol 2D6-1min-1 and the GE experiment resulted in a CLint of 0.188 ± 0.013 µL pmol 2D6-1min-1. The inhibition of PMMA metabolism by fluoxetine was also demonstrated.In the second part of the work, target factor analysis was used as part of a library search algorithm for the identification of drugs in LC-DAD chromatograms. The ability to resolve highly overlapped peaks using the spectral data afforded by the DAD is what distinguished this method from conventional library searching methods. A
Visit Healthgrades for information on Dr. Clint Hill, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Movement: Probably Tuesday I felt something during the day, kind of like a thump that was a similar feeling to having the wind knocked out of you, but really light and only for a second. I wasnt sure if what I was feeling was the baby or not, so I didnt say anything to Clint. Then the next day, at around the same time, I felt the same thing again, and then the same feeling in the afternoon. So this time I called Clint and told him. The next evening we were watching TV and I told him I could feel the same thing, so he tried to listen to see if he could hear the baby. I felt a little kick but didnt say anything, and Clint immediately said Was that it? I was really surprised he could feel it too! Since then I can feel her movements a lot more regularly. The funniest day was Sunday at church, I stood up to sing and then sat back down, and I could feel her kick a few times. Then the next time we stood to sing, same thing happened. I think the service was disturbing her nap, and she wanted me ...
Complete information for AFTPH gene (Protein Coding), Aftiphilin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The chewing texture starts out feeling like pliable plastic, bending easily in my mouth. Theres some initial chewing resistance comparable to overcooked squid steak. Eventually it breaks down and with several chews and takes on a meaty feel, but not exactly like real steak. It still retains some of the chewy, rubbery feel ...
Students at Kuper Academy learned lessons about life on Thursday, courtesy of a former NHL player whos taken more than his share of hard knocks.
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type ...
Slyvester Stallone has already been talking up the next sequel in The Expendables franchise. Theres been a wishlist going around of actors hed like to appear in The Expendables 3 and Clint Eastwood is one of them. In an interview with Extra, the legendary actor, filmmaker and producer was asked whether hed appear in the sequel. When asked, it didnt seem that Eastwood even knew he was wanted in the film. He also stated that hes never seen the films nor has he seen any material in the form of a script. And in the end, his answer was an unfortunate probably not and that hed be more apt to direct something…maybe Ill direct Expendables 3.. At the age of 82, the actor in classic films such as A Fist Full of Dollars, The Good, The Bad and The Ugly, Dirty Harry and City Heat - his prescence in The Expendables franchise would be the epitome of bringing in all of the great action stars that have doned their faces and bodies in cinema. But Im not sure if any form of TRT would be able to get ...
PLYMOUTH - At age 51, country music superstar Clint Black says his music is better than ever. Thats saying something, given he has been on top of the music charts for most of his career.
Clint Miller Exterminating offers free cockroach inspections and roach exterminating services in Mt. Pleasant, Concord, Salisbury, and surrounding areas. Schedule your roach inspection today.
Title: Chess Pieces (or five times Clint and Natasha dont have sex and the first time they do) Authors: rayruz Fandom: Marvel Cinematic Universe Rating: R Characters: Natasha Romanoff, Clint Barton Summary: Clint Barton trusts Natalia Romanova, even when he…
Title: Chess Pieces (or five times Clint and Natasha dont have sex and the first time they do) Authors: rayruz Fandom: Marvel Cinematic Universe Rating: R Characters: Natasha Romanoff, Clint Barton Summary: Clint Barton trusts Natalia Romanova, even when he…
Homo sapiens golgi associated, gamma adaptin ear containing, ARF binding protein 1 (GGA1), transcript variant 2, mRNA. (H00026088-R01) - Products - Abnova
Splinter Cell 3 and Far Cry 2 lead Clint Hocking stood down from Ubisoft Montreal back in May, citing a need to challenge himself and to leave comfortable
Boris Fields with Time De Crespigny and Jarrod Reaper of Your Respite Options. PICS: CLINT ANDERSON BORIS A HERO IN MELBOURNES SOUTH EAST He
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ... and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ...
... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... contains beta and gamma subunits. GRCh38: Ensembl release 89: ENSG00000058262 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... Gamma-adaptin ear homology, ARF-binding proteins) adaptors. Adaptins are distantly related to the other main type of vesicular ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
The other large protein has different designations in the different complexes. In AP-1 it is named γ (gamma), AP-2 has α (alpha ... The two smaller proteins are a medium subunit named μ (mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ...
... the plasma membrane the TCR receptor chains α and β associate with six additional adaptor proteins to form an octameric complex ... The intersection of these specific regions (V and J for the alpha or gamma chain; V, D, and J for the beta or delta chain) ... in the transmembrane domain of each subunit form polar interactions allowing a correct and stable assembly of the complex. The ... LAT associates with another scaffolding protein Slp-76 via the Grap2 adaptor protein, which provides additional binding sites. ...
Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors. AP (adaptor protein) complexes are found in coated vesicles ... AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
... encoding protein cAMP-dependent protein kinase inhibitor gamma PLAGL2: encoding protein Zinc finger protein PLAGL2 POLR3F: ... encoding protein Kizuna centrosomal protein Kua-UEV: LIME1: encoding protein Lck-interacting transmembrane adapter 1 LZTS3: ... Glucocorticoid modulatory element-binding protein 2 GNAS1: Gs alpha subunit (membrane G-protein) GSS: glutathione synthetase ... encoding enzyme Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog VAPB: VAMP (vesicle-associated membrane protein ...
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ...
IFNγ suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, ... sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex ... including subunits of the immunoproteasome (MECL1, LMP2, LMP7), as well as TAP and ERAAP in addition possibly to the direct ... September 1995). "Interaction between the components of the interferon gamma receptor complex". The Journal of Biological ...
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ...
2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an ... "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299- ... CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a ... T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or [email protected] It contributes ...
... domain that is contained in the adaptor protein families Crk, Grb2, and Nck. These adaptor proteins then couple to enzymes to ... An activated complex of GAB2, SHC, and SHP2 is required for binding of Phospholipase C gamma 2 (PLCG2) through its SH2 domain, ... The p85 subunit of PI3K (or PIK3) possessed the SH2 domain required to be activated by GAB2. The activation of the PI3K ... GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking ...
"Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits ... including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765-71. doi: ...
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. The Fc-gamma receptors differ ... Chauhan AK, Moore TL (2012). "Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human ... Chauhan AK, Moore TL (2011). "T cell activation by terminal complex of complement and immune complexes". The Journal of ...
"SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and ... "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (March 1994). "A complex of Grb2 adaptor protein, Sos exchange ...
"The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ... "Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking". Blood. 88 (2): 522-530 ... Lindholm CK, Henriksson ML, Hallberg B, Welsh M (July 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells ... with the p85 subunit of phosphoinositide 3-kinase". FEBS Lett. 575 (1-3): 35-40. doi:10.1016/j.febslet.2004.07.090. PMID ...
Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many ... G-protein coupled receptor signaling pathway. • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway. • G- ... clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2 unable to mobilize ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. Adaptor protein complex 1 is found at the ... Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in ... "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; ... The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein ...
"Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit". Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH ... Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma ... AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene. AP2A2 has been shown to interact with ... the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes ...
"Entrez Gene: COPG2 coatomer protein complex, subunit gamma 2". Bermak JC, Li M, Bullock C, Weingarten P, Zhou QY (Feb 2002). " ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... Coatomer subunit gamma-2 is a protein that in humans is encoded by the COPG2 gene. COPG2 has been shown to interact with ...
The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated. GRCh38 ... 2002). "Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells". ... 1996). "Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI ... Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for ...
This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... Signaling mechanisms - Fc gamma receptorsEdit. ActivationEdit. Fc gamma receptors generate signals within their cells through ... Chauhan, A. K., and Moore, T. L. (2012) Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase ... Chauhan, A. K., and Moore, T. L. (2011) T cell activation by terminal complex of complement and immune complexes. The Journal ...
Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ... clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2 unable to mobilize ... activated DP2 triggers Gi alpha subunit-linked heterotrimeric G proteins to dissociate into their component a) ...
The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor- ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2 ... to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry ...
... the regulatory sub-unit of the PI3K, through tyrosine phosphorylation of adapter protein insulin receptor substrate (IRS1). ... gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice". ... stimulation through direct association of Jak3 and the TCR complex". The Journal of Biological Chemistry. 276 (27): 25378-85. ... JAK3 is activated only by cytokines whose receptors contain the common gamma chain (γc) subunit: IL-2, IL-4, IL-7, IL-9, IL-15 ...
The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with ... 1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio. ... 2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563-7. ... This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which ...
G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex ... "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small ... Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene. GNAI2 has ... Didsbury JR, Ho YS, Snyderman R (Jan 1987). "Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned ...
... a specialized complex composed of proteins, whose expression is induced by interferon gamma, are the primary producers of ... The complex formed with the specialized β subunits is known as the immunoproteasome.[16] Another β5i variant subunit, β5t, is ... the SCF itself is regulated by the APC via ubiquitination of the adaptor protein, Skp2, which prevents SCF activity before the ... The assembled complex of hslV (blue) and hslU (red) from E. coli. This complex of heat shock proteins is thought to resemble ...
Bacteria and fungi may form complex biofilms, protecting from immune cells and proteins; biofilms are present in the chronic ... In parallel, when toll-like receptors in the endocytic compartments recognize a virus the activation of the adaptor protein ... where the transglutaminase polymerizes 210 kDa subunits of a plasma-clotting protein. On the other hand, in the horseshoe crab ... Main article: gamma/delta T cells. Like other 'unconventional' T cell subsets bearing invariant T cell receptors (TCRs), such ...
positive regulation of protein complex assembly. • protein kinase B signaling. • positive regulation of cytokine production. • ... This dissociation enables the adaptor protein TRADD to bind to the death domain, serving as a platform for subsequent protein ... On the other hand, activated caspases cleave several components of the NF-κB pathway, including RIP, IKK, and the subunits of ... positive regulation of interferon-gamma production. • response to glucocorticoid. • positive regulation of vitamin D ...
Ionizable residues in the transmembrane domain of each subunit form a polar network of interactions that hold the complex ... to bind to the ITAM and activated ZAP-70 phosphorylates tyrosines on the adaptor protein LAT, which then attracts PLC-γ. Other ... Likewise, generation of the TCR gamma chain involves VJ recombination, whereas generation of the TCR delta chain occurs by VDJ ... The TCR complex[edit]. The TCR receptor complex is an octomeric complex of variable TCR receptor α and β chains with three ...
G beta-gamma complex Gβ *GNB1. *GNB2. *GNB3. *GNB4. *GNB5. *Gγ *GNGT1 ... Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in ... and thus requires another class of regulatory proteins to accelerate this activity, the GTPase activating proteins (GAPs). ...
Some of the proteins that associate with HATs in these complexes function by targeting the HAT complex to nucleosomes at ... They usually function within a multisubunit complex in which the other subunits are necessary for them to modify histone ... transcriptional adaptor), TFIID (transcription factor II D), TFTC (TBP-free TAF-containing complex), and NuA3/NuA4 (nucleosomal ... Gamma-glutamyl transpeptidase. *Peptidyl transferase. *Transglutaminase *Tissue transglutaminase. *Keratinocyte ...
"Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined ... Seifert, R A; Hart C E; Phillips P E; Forstrom J W; Ross R; Murray M J; Bowen-Pope D F (May 1989). "Two different subunits ... "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". ... "Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth ...
... subunits.[1] In addition, the beta and gamma subunits can form a stable dimeric complex referred to as the beta-gamma complex. ... Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... Phosducin- transducin beta-gamma complex. Beta and gamma subunits of G-protein are shown by blue and red, respectively. ... Types of G protein signaling[edit]. G protein can refer to two distinct families of proteins. Heterotrimeric G proteins, ...
Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... G beta-gamma complex Gβ *GNB1. *GNB2. *GNB3. *GNB4. *GNB5. *Gγ *GNGT1 ... Guanylyl cyclase activator (protein). References[edit]. *^ Sakurai K.; Chen J.; Kefalov V. (2011). "Role of guanylate cylcase ... Guanylate cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and ...
Each molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and ... another multisubunit protein that is essential for mitosis, and a cargo adaptor.[10] The tri-complex, which includes dynein, ... The dynactin complex is composed of more than 20 subunits,[17] of which p150(Glued) is the largest.[18] There is no definitive ... mediates the attachment of several cargo adaptors to the dynein motor.[11] The other tail subunits may also help facilitate ...
"The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled ... Sato, K; Kimoto M, Kakumoto M, Horiuchi D, Iwasaki T, Tokmakov A A, Fukami Y (September 2000). "Adaptor protein Shc undergoes ... "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". ... a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases ...
The Gs alpha subunit of the stimulated G protein complex exchanges GDP for GTP and is released from the complex.[7] ... which results in the Gs alpha subunit's exchanging GDP for GTP and separation from the beta and gamma subunits. The Gs alpha ... Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... cAMP binds to the regulatory sub-units.[16] It causes them to break apart from the catalytic sub-units. The Catalytic sub-units ...
protein serine/threonine kinase activity. • macromolecular complex binding. • phosphatidylinositol-4,5-bisphosphate 3-kinase ... Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein ... Fc-gamma receptor signaling pathway involved in phagocytosis. • ruffle organization. • actin filament organization. • cell ... "Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated ...
The gamma subunit of this complex acts as a serine protease, and cleaves the N-terminal of the beta subunit, thereby activating ... This pathway begins with the Trk receptor complex-recruitment of a second adaptor protein called growth factor-receptor bound ... NGF is initially in a 7S, 130-kDa complex of 3 proteins - Alpha-NGF, Beta-NGF, and Gamma-NGF (2:1:2 ratio) when expressed. This ... 26-kDa beta subunit of the protein, the only component of the 7S NGF complex that is biologically active (i.e. acting as ...
Signal transducing adaptor protein. *Scaffold protein. Transcription factors. *General. *Transcription preinitiation complex ... They have a heteromeric structure in that each subunit consists of the extracellular ligand-binding domain and a transmembrane ... and can be a protein or peptide (short protein), or another small molecule such as a neurotransmitter, hormone, pharmaceutical ... In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.[1] When ...
Ca2+/calmodulin-dependent protein kinases or CaM kinases. are primarily regulated by the Ca2+/calmodulin complex. ... Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... RNA-polymerase)-subunit kinase (EC 2.7.11.23). *RPS6KA5. *RPS6KA4. *P70S6 kinase. *P70-S6 Kinase 1 ... Protein kinase C ('PKC'). is actually a family of protein kinases consisting of ~10 isozymes. They are divided into three ...
G protein-gated ion channel. *Gamma-aminobutyric acid receptor subunit alpha-1 ... AP2 adaptor complex. *Aaron Klug. *Acid-sensing ion channel. *Activating function. *Active transport ...
"Entrez Gene: COPG2 coatomer protein complex, subunit gamma 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd= ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... Waters MG, Serafini T, Rothman JE (1991). "'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated ...
links are to the catalytic subunit) All but PPP2C have sequence homology in the catalytic domain, but differ in substrate ... G beta-gamma complex Gβ *GNB1. *GNB2. *GNB3. *GNB4. *GNB5. *Gγ *GNGT1 ... Signal transducing adaptor protein. *I-kappa B protein. *Mucin-4. *Olfactory marker protein ... Ser/Thr-specific protein phosphatases are regulated partly by their location within the cell and by specific inhibitor proteins ...
The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay ... Jefferies C, Bowie A, Brady G, Cooke EL, Li X, O'Neill LA (July 2001). "Transactivation by the p65 subunit of NF-kappaB in ... March 2002). "Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response ... "Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in ...
"Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. ... Riordan SM, Lidder S, Williams R, Skouteris GG (2000). "The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF ... 1990). "Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors". Science. 250 ( ... Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This ...
... may interact directly with APC subunit APC10 and thus recruit the APC complex. CDH1 subunit of the APC complex recognizes NEDD9 ... "Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease" (Oncoscience ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ...
Compare adaptor related protein complex 1 subunit gamma 2 ELISA Kits from MyBioSource.com from leading suppliers on Biocompare ... adaptor related protein complex 1 subunit gamma 2 ELISA Kits from MyBioSource.com. Clear ... adaptor related protein complex 1 subunit gamma 2 ELISA Kits from MyBioSource.com. ... adaptor related protein complex 1 subunit gamma 2 ELISA Kits from MyBioSource.com. ...
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Protein Coding), Adaptor Related Protein Complex 1 Subunit Gamma 2, including: function, proteins, disorders, pathways, ... The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... AP1G2 (Adaptor Related Protein Complex 1 Subunit Gamma 2) is a Protein Coding gene. Diseases associated with AP1G2 include Long ... AP1G2 Gene(Protein Coding) Adaptor Related Protein Complex 1 Subunit Gamma 2. ...
... viral and bacterial proteins. It has been found in each of the main cellular compartments including ... p32/gC1qR is a small acidic protein that has been reported to have a broad range of distinct functions and to associate with a ... Adaptor Protein Complex gamma Subunits. Animals. Biotinylation. COS Cells. Calcium-Binding Proteins / metabolism. Calnexin. ... 0/Adaptor Protein Complex gamma Subunits; 0/Calcium-Binding Proteins; 0/Calreticulin; 0/Membrane Glycoproteins; 0/Membrane ...
The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the ... Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi ... Subunit structurei. Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit ... Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi ...
Ausgesuchte Qualitäts-Hersteller für gamma 1 Adaptin Antikörper. Hier bestellen. ... Monoklonale und polyklonale gamma 1 Adaptin Antikörper für viele Methoden. ... AP-1 complex subunit gamma-1 , adapter-related protein complex 1 subunit gamma-1 , adaptor protein complex AP-1 subunit gamma-1 ... gamma 1 , gamma adaptin , golgi adaptor HA1/AP1 adaptin gamma subunit , adaptor protein complex AP-1 gamma 1 subunit , adaptor ...
PIPKIgamma also interacts with the mu subunits of clathrin adaptor protein (AP) complexes Title: Type I gamma ... adaptor protein complex AP-1 mu-2 subunit. adaptor related protein complex 1 mu 2 subunit. clathrin assembly protein complex 1 ... AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo sapiens] AP1M2 adaptor related protein complex 1 subunit mu 2 [Homo ... clathrin-associated adaptor medium chain mu2. golgi adaptor AP-1 47 kDa protein. golgi adaptor HA1/AP1 adaptin mu-2 subunit. mu ...
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.  Touhara, K; Hawes, BE; van Biesen, T; ... Cyclic AMP-Dependent Protein Kinases. Heterotrimeric GTP-Binding Proteins. Protein Subunits. Recombinant Proteins. Spodoptera. ... Gi-coupled receptors is known to involve the beta gamma subunits of heterotrimeric G proteins (G beta gamma), p21ras activation ... domain with the beta and gamma subunits of heterotrimeric G proteins (Gbetagamma). An improved purification scheme for GRK2 has ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ... and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, ...
... mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP) ... Disruption of the APP-AP-4 interaction decreases localization of APP to endosomes and enhances gamma-secretase-catalyzed ... Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the ... Sorting of the Alzheimers disease amyloid precursor protein mediated by the AP-4 complex.. Burgos, P.V., Mardones, G.A., Rojas ...
... adaptor-related protein complex 1, gamma 1 subunit) for ELISA, IHC-P, WB. Anti-gamma Adaptin pAb (GTX37788) is tested in Human ... The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... adaptor-related protein complex 1, gamma 1 subunit. Background. Adaptins are important components of clathrin-coated vesicles ... CLAPG1 Antibody , ADTG Antibody , adaptor-related protein complex 1, gamma 1 subunit Antibody , AP1G1 Antibody. ...
Protein Coding), Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3, including: function, proteins, disorders, pathways, ... Interacts with AP4M1 and GRIA1; associates GRIA1 with the adaptor protein complex 4 (AP-4) to target GRIA1 to the ... Protein Symbol:. O60359-CCG3_HUMAN. Recommended name:. Voltage-dependent calcium channel gamma-3 subunit. Protein Accession:. ... CACNG3 Gene (Protein Coding) Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3. ...
... a number of adaptor proteins are needed. These can be classified into four subunit polymeric adaptor protein complexes (APs;* ... and the gamma appendage domain of the adaptor protein complex 1 (AP1). In cells, its distribution overlaps with the perinuclear ... GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J. Cell ... Abbreviations used in this paper: AP, adaptor protein complex; AP180, AP of 180 kD; CCV, clathrin-coated vesicle; EEA1, early ...
... core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex ... probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to ... associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/ ... section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ... "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical ...
Human Sec61 alpha 1 subunit (S. cerevisiae) (SEC61A1) available for purchase from OriGene - Your Gene Company. ... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... contains beta and gamma subunits. [provided by RefSeq, Jul 2008]. SC115289 has not yet been cited specifically in any ... Lenti ORF clone of Sec61a1 (Myc-DDK-tagged ORF) - Rat Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1), (10 ug). $772. 8 weeks. ...
Adaptor-Related Protein Complex 1, mu 1 Subunit ELISA Kits * Adaptor-Related Protein Complex 1, gamma 1 Subunit ELISA Kits ... adapter-related protein complex 2 mu subunit , adaptin-mu2 , adaptor protein complex AP-2 subunit mu , clathrin adaptor complex ... adaptor related protein complex 2 mu 1 subunit (AP2M1) Elisa Kit * adaptor-related protein complex 2, mu 1 subunit, a (ap2m1a) ... adaptor-related protein complex 2, mu 1 subunit (Ap2m1) Elisa Kit * adaptor related protein complex 2 mu 1 subunit L homeolog ( ...
AP1G2 fusion protein Ag12300 Full name: adaptor-related protein complex 1, gamma 2 subunit ...
adaptor related protein complex 1 sigma 1 subunit. The protein encoded by this gene is part of the clathrin coat assembly ... This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein ... adaptor related protein complex 1 sigma 1 subunit. AP19;CLAPS1;EKV3;MEDNIK;SIGMA1A. NM_001283.3. rs13225397. ... adaptor related protein complex 1 sigma 1 subunit. AP19;CLAPS1;EKV3;MEDNIK;SIGMA1A. NM_001283.3. rs2239537. ...
The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... Adaptor related protein complex 1 mu 1 subunit. Protein classi. Protein class the gene product belongs to according to selected ... The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located ... Adaptor related protein complex 1 mu 1 subunit (HGNC Symbol). Entrez gene summary. The protein encoded by this gene is the ...
... and these Arf GEFs are associated with recruitment of adaptor protein complex 1 (AP1) and Golgi-localized gamma-ear-containing ... Nef accomplishes this rerouting by promoting a direct interaction between the mu subunit of the clathrin coat adaptor protein ... Protein 2C disrupts the Golgi but has no apparent effect on protein secretion (12, 48). Conversely, protein 2B inhibits protein ... protein complexes. Both complexes are involved in clathrin-dependent trafficking. In addition to these coats, Arf proteins also ...
Browse our Gamma Adaptin Antibody catalog backed by our Guarantee+. ... anti-Adapter-related protein complex 1 subunit gamma-1 antibody, anti-Adaptor protein complex AP-1 subunit gamma-1 antibody, ... anti-adaptor-related protein complex 1, gamma 1 subunit antibody, anti-ADTGclathrin assembly protein complex 1 gamma large ... anti-AP-1 complex subunit gamma-1 antibody, anti-CLAPG1clathrin-associated/assembly/adaptor protein, large, gamma 1 antibody, ...
... complexes, and the monomeric GGA (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors [(PUBMED: ... and the zeta and delta subunits of various coatomer (COP) adaptors. The small sigma subunit of AP proteins have been ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) ... All AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit ( ...
The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a ... probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. ... The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription ... SUBUNIT STRUCTURE: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; ...
A Signaling Complex Comprised of the Adapter Proteins Chat-H and CasL Regulates Activated but not Homeostatic T Cell Migration ... RACK1 Regulates Directional Cell Migration by Acting on G Protein beta gamma Subunits at the Interface with its Effectors ... Short Talk: The role of a cell-motility inducing protein, autotaxin, in high endothelial venules of lymph nodes and Peyers ... Immune Complex-Mediated Leukocyte Trafficking and Injury In vivo. Andrew H. Lichtman, Brigham and Womens Hospital, USA ...
AP-1 heterotetrameric complex contains a gamma-adaptin subunit bearing a gamma-ear at its carboxy terminus, while Ggas are ... The Gamma-ear interaction motif interacts with gamma-ear domains of adaptor proteins involved in clathrin coated vesicles ... By analogy with AP-2 (the well characterized adaptor complex involved in endocytic CCV formation) the gamma-ear domain of AP-1 ... Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif.. Duncan MC, ...
... is the most recently discovered and least well-characterized member of the family of heterotetrameric adaptor protein (AP) ... complexes that mediate sorting of transmembrane cargo in post-Golgi compartments. Herein, we report the interaction of an YKFFE ... Disruption of the APP-AP-4 interaction decreases localization of APP to endosomes and enhances gamma-secretase-catalyzed ... with the mu4 subunit of AP-4. Biochemical and X-ray crystallographic analyses reveal that the properties of the APP sequence ...
Cytokine receptor common gamma subunit (IL2RG, IL-2 receptor gamma chain, Gc) associates with Tyrosine-protein kinase JAK3 ( ... Complex. R-HSA-508510 (Reactome) JAK3. Protein. P52333 (Uniprot-TrEMBL) LCK Protein. P06239 (Uniprot-TrEMBL) LGALS9 Protein. ... 1994). Grb2 is an adaptor protein believed to be constitutively associated with the guanine nucleotide exchange protein Sos1 ( ... Complex. R-HSA-452094 (Reactome) STAT5B Protein. P51692 (Uniprot-TrEMBL) SYK Protein. P43405 (Uniprot-TrEMBL) SYK. Protein. ...
Adaptor Protein Complex alpha Subunits. *Adaptor Protein Complex gamma Subunits. *Adaptor Proteins, Vesicular Transport ... Adaptor Protein Complex alpha Subunits. *Adaptor Protein Complex gamma Subunits. *Adaptor Proteins, Vesicular Transport ... When analyzed by SDS-PAGE followed by protein staining, the dense fractions exhibited the typical protein profile of purified ... When analyzed by SDS-PAGE followed by protein staining, the dense fractions exhibited the typical protein profile of purified ...
adaptor-related protein complex 1, sigma 2 subunit APOC1 apolipoprotein C-I ... gamma-aminobutyric acid (GABA) A receptor, pi GATA3 GATA binding protein 3 ... inhibitor of DNA binding 2, dominant negative helix-loop-helix protein ID4 inhibitor of DNA binding 4, dominant negative helix- ... about genes and proteins. Database (Oxford). 2016 Jul 3;2016. pii: baw100. ...
  • Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. (duke.edu)
  • G protein-coupled receptor kinase 2 (GRK2) phosphorylates activated G protein-coupled receptors (GPCRs), which ultimately leads to their desensitization and/or downregulation. (duke.edu)
  • This gene encodes a member of the serine/threonine protein kinase family. (merckmillipore.com)
  • Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway. (wikipathways.org)
  • In this model, we observed that HCV proteins control cellular translation through eIF-2α-S51 phosphorylation, with involvement of the double-stranded RNA-dependent protein kinase PKR. (biomedcentral.com)
  • Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. (mybiosource.com)
  • The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. (mybiosource.com)
  • This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. (mybiosource.com)
  • The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. (mybiosource.com)
  • Also known as Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4). (mybiosource.com)
  • Also known as Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP). (mybiosource.com)
  • The receptor-mediated activation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5) P 2 ] with the resultant production of inositol 1,4,5-trisphosphate (InsP 3 ) and diacylglycerol (DAG), the two second messengers linked to Ca 2+ signaling and protein-kinase-C-mediated phosphorylations, respectively, had become textbook knowledge by the early 90s. (biologists.org)
  • It was originally characterized as an interacting partner of atypical protein kinase C (aPKC), which is mediated through the Phox and Bem1p (PB1) domain, a domain conserved on the N terminus of p62 that can cause p62 to either homodimerize or heterodimerize with the PB1 domain of other proteins ( 6 ). (pubmedcentralcanada.ca)
  • When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. (bioon.com.cn)
  • The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. (nih.gov)
  • A pivotal step in the stimulation of this pathway is the activation of the cytoplasmic IkB-kinase (IKK) complex, which consists of two catalytic subunits, IKK-alpha and beta and a regulatory subunit, IKK-gamma/NEMO. (biomedcentral.com)
  • DDR is primarily mediated by phosphatidylinositol-3-kinase-like protein kinase (PIKKs) family members ataxia-telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related protein (ATR). (intechopen.com)
  • The phosphorylated ITAM then recruits the protein tyrosine kinase SYK (spleen tyrosine kinase) which then phosphorylates the adaptor protein LAT. (reactome.org)
  • Degranulation or histamine release follows the activation of PLC-gamma and protein kinase C (PKC) and the increased mobilization of calcium (Ca2+). (reactome.org)
  • Rasl and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. (springer.com)
  • Basler K, Hafen E. Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. (springer.com)
  • CTD kinase subunit gamma CTK3 (IPR024638) The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key. (ebi.ac.uk)
  • Serine/threonine-protein kinase SMG1, N-terminal (IPR035175) This entry represents the N-terminal domain of SMG1, which is a member of the phosphoinositide 3 kinase -like kinase (PIKK) family. (ebi.ac.uk)
  • The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division , cell adhesion , and stress response. (wikidoc.org)
  • This protein constitutes a regulatory subunit of the AMP-activated protein kinase (AMPK). (atlasgeneticsoncology.org)
  • Mutations at the PRAAG2 (encoding the gamma2 subunit of AMP-activated protein kinase) causes glycogen overload, Wolff-Parkinson-White syndrome, arrhythmias, and heart failure. (atlasgeneticsoncology.org)
  • and TRAF2 recruit IKK-gamma and IKK alpha/beta subunits of IKK (inhibitor of nuclear factor kappa B kinase ) complex respectively [ 3 ], [ 4 ]. (bio-rad.com)
  • AMPK Beta 2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). (fishersci.com)
  • Studies indicate that in response to stimulation with antigen, PHB1 translocated to plasma membrane lipid rafts to form a ternary complex with the high-affinity IgE receptor FcepsilonRIgamma and the nonreceptor tyrosine kinase Syk. (cusabio.com)
  • Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. (duke.edu)
  • Phospho-Blnk acts as a scaffold for the assembly of the other components, including Bruton's tyrosine kinase (Btk), Vav 1, and phospholipase C-gamma 2 (PLCγ2) [3]. (apexbt.com)
  • The original RAS signal is transmitted and amplified through the mitogen-activated protein kinase (MAPK) pathway, which including the serine/threonine-specific protein kinase RAF followed by MEK and extracellular signal related kinases ERK 1 and 2 [4]. (apexbt.com)
  • Once TCR connected with its ligand, the ζ-chain-associated protein kinase 70 molecules (Zap-70) are recruited to the TCR-CD3 site and activated, resulting in an initiation of several signaling cascades. (apexbt.com)
  • and a sequential protein kinase cascade is initiated, consisting of MAP kinase kinase kinase (MAP3K), MAP kinase kinase (MAPKK), and MAP kinase (MAPK) [6]. (apexbt.com)
  • These findings demonstrate that APP and AP-4 engage in a distinct type of signal-adaptor interaction that mediates transport of APP from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. (rcsb.org)
  • It mediates the interaction between the 2 proteins Ent3p and Ent5p and the gamma-ear domains of Gga2p and AP-1. (eu.org)
  • subunits mediates recognition of YXXØ-signals by means of a critical aspartic acid. (jove.com)
  • A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein. (genes2cognition.org)
  • A membrane proximal conserved GYxxØ motif mediates endocytosis through interaction with the clathrin adaptor AP-2. (genes2cognition.org)
  • The complex mediates the recruitment of clathrin to the vesicle membrane. (ox.ac.uk)
  • Four proteins in this group, RGS6, RGS7, RGS9, and RGS11, share a common molecular organization of three modules: (i) the catalytic RGS domain, (ii) a GGL domain that recruits Gβ 5 , an outlying member of the G protein beta subunit family, and (iii) a DEP/DHEX domain that mediates interactions with the membrane anchor proteins R7BP and R9AP. (springer.com)
  • G protein signaling mediates the perception of environmental cues in all higher eukaryotic organisms, including yeast, Dictyostelium, plants, and animals. (patentgenius.com)
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. (duke.edu)
  • Phosphorylation of the IκB cytoplasmic inhibitors, IκBα, IκBβ and IκBγ by these kinases triggers proteolytic degradation and the release of NFκB/Rel proteins from the IκB inhibitors. (merckmillipore.com)
  • The IKK complex associates with TERF2IP /RAP1, leading to promote IKK-mediated phosphorylation of RELA /p65 (PubMed:20622870). (rcsb.org)
  • Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. (bioon.com.cn)
  • The first step in FCERI signaling is the phosphorylation of the tyrosine residues in the ITAM of both the beta and the gamma subunits of the FCERI by LYN, which is bound to the FCERI beta-chain. (reactome.org)
  • Tyrosoine phosphorylation of enzymes and adaptors, including VAV, SHC GRB2 and SOS stimulate small GTPases such as RAC, RAS and RAF. (reactome.org)
  • FCERI activation also triggers the phosphorylation of PLC-gamma which upon membrane localisation hydrolyse PIP2 to form IP3 and 1,2-diacylglycerol (DAG) - second messengers that release Ca2+ from internal stores and activate PKC, respectively. (reactome.org)
  • Receptor aggregation also results in the phosphorylation of adaptor protein NTAL/LAT2 which then recruits GAB2. (reactome.org)
  • Phosphorylation at Ser108 is required for the activation of the AMPK enzyme, whereas phosphorylation at Ser24/25 and Ser182 affects the localization of the complex. (atlasgeneticsoncology.org)
  • Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-172 of the AMPKa regulatory subunit (PRKAA) by LKB1 in complex with STE20-related adapter-alpha (STRAD alpha). (atlasgeneticsoncology.org)
  • The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. (fishersci.com)
  • proteins between GM1 and oligomer initial transcription proteins must provide exposed with phosphorylation and for this energy receptors from proton repair removed annotated also in this dendrite. (evakoch.com)
  • AMPKbeta1, may act as a positive regulator of AMPK activity and it may serve as an adaptor molecule for the catalytic subunit. (atlasgeneticsoncology.org)
  • AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. (fishersci.com)
  • This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. (nih.gov)
  • This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. (origene.com)
  • This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. (nih.gov)
  • The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. (genecards.org)
  • The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. (genecards.org)
  • Zusätzlich bieten wir Ihnen gamma 1 Adaptin Proteine (3) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • We identify dynamin and the EAP -binding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in clathrin mediated endocytosis. (antikoerper-online.de)
  • This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. (thermofisher.com)
  • We offer Gamma Adaptin Antibodies for use in common research applications: Electron Microscopy, ELISA, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western Blot. (novusbio.com)
  • Each Gamma Adaptin Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Choose from our Gamma Adaptin polyclonal antibodies and browse our Gamma Adaptin monoclonal antibody catalog. (novusbio.com)
  • Adaptin subunits recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal appendage domains. (embl.de)
  • By contrast, GGAs are monomers composed of four domains, which have functions similar to AP subunits: an N-terminal VHS (Vps27p/Hrs/Stam) domain, a GAT (GGA and Tom1) domain, a hinge region, and a C-terminal GAE (gamma-adaptin ear) domain. (embl.de)
  • This conserved domain, referred as gamma adaptin ear (GAE), functions as a platform for recruitment of accessory proteins at the TGN. (eu.org)
  • AP-1 heterotetrameric complex contains a gamma-adaptin subunit bearing a gamma-ear at its carboxy terminus, while Ggas are monomeric adaptor proteins containing a C-terminal domain related to the ear domain of gamma-adaptin. (eu.org)
  • Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif. (eu.org)
  • 271:2162-2170).Using a polyclonal antibody against the mouse gamma-adaptin, we have now examined the steady state distribution of AP-1 after subcellular fractionation of mouse fibroblasts lacking both MPRs or reexpressing physiological levels of either MPR. (nih.gov)
  • The golgi-localized gamma-ear-containing Arf (GGA) effector binding proteins contain an amino-terminal VHS domain, a GGA homology domain (GGAH), a proline-rich linker region and a carboxy-terminal gamma-ear adaptin homology domain (AGEH). (thermofisher.com)
  • Interestingly, a non-canonical tyrosine-based motif, which contains two tyrosine residues, Tyr-6 and Tyr-8, present in the NH2-terminal cytoplasmic tail, was essential for endocytosis through interaction with an Deltaa-adaptin, but not mu2-subunit, of the AP-2 complex. (genes2cognition.org)
  • Indeed, an appendage domain of alpha-adaptin was identified as a protein interacting with the cytoplasmic tail of HM1.24. (genes2cognition.org)
  • A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. (genes2cognition.org)
  • We also present evidence that the diacidic motif on Nef and the basic patch on alpha-adaptin are both required for the cooperative assembly of a CD4-Nef-AP-2 complex. (genes2cognition.org)
  • AP1S2 encodes an adaptin protein that constitutes part of the adaptor protein complex found at the cytoplasmic face of coated vesicles located at the Golgi complex. (ox.ac.uk)
  • Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (embl.de)
  • The medium (mu) adaptins of all AP complexes can recognise and interact with tyrosine-based (YXXphi) sorting signals found within the cytoplasmic tails of integral membrane proteins (Aguilar et al. (reactome.org)
  • Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. (string-db.org)
  • G protein-coupled receptors (GPCRs) such as DP 2 are integral membrane proteins that, when bound by their cognate ligands (or, in some cases, even when not ligand-bound and thereby acting continuously in a constitutive manner {see Receptor (biochemistry)#Constitutive activity }), mobilize one or more types of Heterotrimeric G proteins . (wikipedia.org)
  • A gene on chromosome 5q14.1 that encodes a subunit of the heterotetrameric AP3 complex, a protein complex composed of two large subunits (delta and beta), a medium subunit (mu), and a small subunit (sigma). (thefreedictionary.com)
  • The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. (thermofisher.com)
  • Clathrin coats contain both clathrin and adaptor complexes that link clathrin to receptors in coated vesicles. (embl.de)
  • Although sometimes considered to be within this family, the IL4 and IL7 receptors can form complexes with other receptor chains and are represented separately in Reactome. (wikipathways.org)
  • Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors. (wikipathways.org)
  • The transport of the two mannose 6-phosphate receptors (MPRs) from the secretory pathway to the endocytic pathway is mediated by carrier vesicles coated with the AP-1 Golgi-specific assembly protein and clathrin. (nih.gov)
  • TRAF5, a member of the TNF Receptor-Associated Factor family, is an adaptor protein and E3 ubiquitin ligase which functions downstream various membrane receptors, notably for the activation of the NF-kB pathway. (biomedcentral.com)
  • May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. (string-db.org)
  • the membrane-associated pool colocalizes with transferrin and EGF receptors (EGFRs) and early endosome antigen 1, but not with LAMP1 protein. (pnas.org)
  • Desensitization of G protein-coupled receptors and neuronal functions. (springer.com)
  • Electronic Collection is the racking sack" of Similar retained Avitaminoses Complete on the necrosis only optimally as central chains that directly cause in Canada or are of protein to receptors. (evakoch.com)
  • For example, those that bind the most common class of antibody, IgG , are called Fc-gamma receptors (FcγR), those that bind IgA are called Fc-alpha receptors (FcαR) and those that bind IgE are called Fc-epsilon receptors (FcεR). (wikipedia.org)
  • This property allows FcγRI to bind a sole IgG molecule (or monomer ), but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. (wikipedia.org)
  • The Fc-gamma receptors differ in their affinity for IgG and likewise the different IgG subclasses have unique affinities for each of the Fc gamma receptors. (wikipedia.org)
  • sub.q protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. (patentgenius.com)
  • This invention relates to G.alpha.q protein variants and their use in the analysis and discovery of agonists and antagonsists of chemosensory receptors, such as G protein coupled receptors involved in sensing of tastants, olfactants, andpheromones. (patentgenius.com)
  • Heterotrimeric G proteins, consisting of alpha, beta and gamma subunits, couple ligand-bound seven transmembrane domain receptors (GPCRs or G-protein coupled receptors) to the regulation of effector proteins and production of intracellular secondmessengers such as cAMP, cGMP, and Ca.sup.2+. (patentgenius.com)
  • Agonist-bound sensory receptors catalyze theexchange of GTP for GDP on the surface of the G.alpha.a subunit to initiate intracellular responses to extracellular signals. (patentgenius.com)
  • ATG5: ATG12: nonsyndromic due residues seem fatty species( receptors and thus neonatal channels), ATG5: ATG12: classic GAB1 inhibitors can confer encoded to keep systems, and ATG5: ATG12: full infectious components can form characterized as first proteins( Tandia et al. (evakoch.com)
  • Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. (genecards.org)
  • Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells. (nih.gov)
  • The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). (genecards.org)
  • Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. (genecards.org)
  • Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. (wikipathways.org)
  • Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells. (wikipathways.org)
  • Typically, the dense fractions contained the clathrin light chain, the γ- and α-adaptins, as well as transmembrane proteins like the transferrin receptor and the CI-MPR, as determined by Western blotting. (nih.gov)
  • B-fragment sorting at the level of early/recycling endosomes seemed to involve vesicular coats, since brefeldin A treatment led to B-fragment accumulation in transferrin receptor-containing membrane tubules, and since B-fragment colocalized with adaptor protein type 1 clathrin coat components on early/recycling endosomes. (nih.gov)
  • Other domains encoded in p62 are the ZZ-type zinc finger domain that binds receptor-interacting protein-1 (RIP1) and the TRAF6 binding site (TBS), which both have been shown to activate the NF-κB signaling pathway ( 21 ). (pubmedcentralcanada.ca)
  • The VHS domain interacts with cytoplasmic domains for receptor sorting, the GGAH domain binds activated Arf, the proline-rich region interacts with clathrin and the AGEH domain interacts with cytosolic proteins. (thermofisher.com)
  • Arf6 is differentiated from the other Arf proteins due to its plasma membrane association and its involvement in the regulation of receptor mediated endocytosis and remodeling of the actin cytoskeleton. (thermofisher.com)
  • The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. (bioon.com.cn)
  • Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. (bioon.com.cn)
  • Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila . (springer.com)
  • Thus, TBC1D16 is a GTPase activating protein for Rab4A that regulates transferrin receptor recycling and EGFR trafficking and signaling. (pnas.org)
  • Binding of the inherently trimeric TNF-alpha to TNFR1 induces receptor trimerization and recruitment of TNFR1-associated death domain protein ( TRADD), which serves as a platform to recruit at least three additional mediators: receptor-interacting protein 1 ( RIP1 ), Fas-associated death domain protein ( FADD ), TNF-receptor-associated factor 2 ( TRAF2 ). (bio-rad.com)
  • The adaptor protein transmits an activating signal from the activated receptor TNFR1 to some signaling cascades - caspase cascade with subsequent apoptosis, NF-kB activating cascade and JNK cascade [ 1 ]. (bio-rad.com)
  • The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. (cusabio.com)
  • G protein-coupled receptor associated sor. (broadinstitute.org)
  • G protein-coupled receptor signaling pathways mediate the transmission of signals from the extracellular environment to the generation of cellular responses, a process that is critically important for neurons and neurotransmitter action. (springer.com)
  • Prostaglandin D 2 receptor 2 ( DP 2 or CRTH2 ) is a human protein encoded by the PTGDR2 gene and GPR44. (wikipedia.org)
  • It consists of two introns and three exons and codes for a G protein coupled receptor (GPCR) composed of 472 amino acids. (wikipedia.org)
  • Central process of T cells responding to specific antigens is the binding of the T-cell receptor (TCR) to specific peptides bound to the major histocompatibility complex which expressed on antigen-presenting cells (APCs). (apexbt.com)
  • [11] This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein . (wikipedia.org)
  • subunits also contribute to the specificity of receptor-G protein coupling (Xuet al. (patentgenius.com)
  • All AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). (embl.de)
  • The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (uniprot.org)
  • During CCV formation (less well characterized for internal membranes than for endocytosis), clathrin and clathrin adaptors interact to nucleate coat assembly by binding to appropriate membranes and recruit cargo molecules, clathrin and other coat associated proteins. (eu.org)
  • Adaptor protein (AP) complexes facilitate protein trafficking by playing key roles in the selection of cargo molecules to be sorted in post-Golgi compartments. (jove.com)
  • led to the current notion that production of specific inositol lipids in well-defined membrane compartments upon stimulation helps recruit signaling molecules to membranes and hence contributes to the organization of signaling complexes. (biologists.org)
  • In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. (rcsb.org)
  • FCERI signaling in mast cells includes a network of signaling molecules and adaptor proteins. (reactome.org)
  • of adaptor molecules. (ebi.ac.uk)
  • The BCR-ABL protein can be inhibited by various small molecules. (wikidoc.org)
  • and in a group of small adaptor molecules, i.e Crk and Nck. (ebi.ac.uk)
  • Many key transcription factors, signaling molecules and structural proteins necessary for myogenesis and muscle growth have been identified. (biomedcentral.com)
  • The true physiological role(s) of p32 remains controversial because it has been difficult to reconcile all of the findings on protein interactions and the seemingly disparate observations on compartmentalisation. (biomedsearch.com)
  • p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex). (uniprot.org)
  • Biochemical and X-ray crystallographic analyses reveal that the properties of the APP sequence and the location of the binding site on mu4 are distinct from those of other signal-adaptor interactions. (rcsb.org)
  • multiple interactions between PIPKI gamma- p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin -mediated synaptic vesicle endocytosis. (antikoerper-online.de)
  • V1H can function as an adaptor for interactions between Nef and AP-2 (zeige GTF3A ELISA Kits ). (antikoerper-online.de)
  • By analogy with AP-2 (the well characterized adaptor complex involved in endocytic CCV formation) the gamma-ear domain of AP-1 and Ggas probably mediate interactions with accessory proteins during CCV formation. (eu.org)
  • Comparison of the structural features of these domains not only reveals a high degree of conservation of their lipid interaction sites but also highlights their evolutionary link to protein modules known for protein-protein interactions. (biologists.org)
  • Protein-protein interactions involving lipid-binding domains could serve as the basis for phosphoinositide-induced conformational regulation of target proteins at biological membranes. (biologists.org)
  • Here, I focus on the structural and functional similarities between these modules, emphasising their proven or potential protein-protein interactions in combination with their lipid-binding properties. (biologists.org)
  • How precisely PI(4,5)P(2) metabolism is controlled spatially and temporally is still uncertain, but recent data indicate that direct interactions between type I PIPK and components of the endocytic machinery, in particular the AP-2 adaptor complex, are involved. (rcsb.org)
  • Our data also suggest that interactions between AP-2 and the tail domain of PIPKI gamma-p90 may serve to regulate complex formation and enzymatic activity. (rcsb.org)
  • This cooperativity explains how Nef is able to efficiently downregulate CD4 despite weak binary interactions between components of the tripartite complex. (genes2cognition.org)
  • Large-scale mapping of human protein-protein interactions by mass spectrometry. (genes2cognition.org)
  • Mapping protein-protein interactions is an invaluable tool for understanding protein function. (genes2cognition.org)
  • Here, we report the first large-scale study of protein-protein interactions in human cells using a mass spectrometry-based approach. (genes2cognition.org)
  • The study maps protein interactions for 338 bait proteins that were selected based on known or suspected disease and functional associations. (genes2cognition.org)
  • Large-scale immunoprecipitation of Flag-tagged versions of these proteins followed by LC-ESI-MS/MS analysis resulted in the identification of 24,540 potential protein interactions. (genes2cognition.org)
  • False positives and redundant hits were filtered out using empirical criteria and a calculated interaction confidence score, producing a data set of 6463 interactions between 2235 distinct proteins. (genes2cognition.org)
  • This data set was further cross-validated using previously published and predicted human protein interactions. (genes2cognition.org)
  • In-depth mining of the data set shows that it represents a valuable source of novel protein-protein interactions with relevance to human diseases. (genes2cognition.org)
  • In addition, via our preliminary analysis, we report many novel protein interactions and pathway associations. (genes2cognition.org)
  • This review summarizes our current understanding of the biology of the R7 RGS complexes including their structure/functional organization, protein-protein interactions, and physiological roles. (springer.com)
  • DS remains the most specific download modeling biological systems principles and in gene but is then used in type proteins, disorder interactions, copies, and the heterodimers. (evakoch.com)
  • EpsinR is a clathrin-coated vesicle (CCV) enriched 70-kD protein that binds to phosphatidylinositol-4-phosphate, clathrin, and the gamma appendage domain of the adaptor protein complex 1 (AP1). (pubmedcentralcanada.ca)
  • Recently we found that a non-canonical YXXØ-signal on the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP) binds to a distinct region of the ?4 subunit of the AP-4 complex. (jove.com)
  • Through mutational studies, the GGAH domain has been shown to be sufficient to bind GTP-bound Arf, and Arf1 binds all three GGA effector proteins. (thermofisher.com)
  • Crystallographic data show that a peptide derived from the splice insert of the human PIPKI gamma-p90 tail binds to a cognate recognition site on the sandwich subdomain of the beta2 appendage. (rcsb.org)
  • This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. (fishersci.com)
  • Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. (genecards.org)
  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. (duke.edu)
  • Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (embl.de)
  • This traffic is bidirectional, to ensure that proteins required to form vesicles are recycled. (embl.de)
  • Thus, these results indicate that the concentration of the MPRs, i.e., the major transmembrane proteins sorted toward the endosomes, determines the number of clathrin-coated vesicles formed in the TGN. (nih.gov)
  • A) Protein profile of the vesicles isolated from mouse fibroblasts after SDSPAGE and silver staining (left). (nih.gov)
  • When analyzed by SDS-PAGE followed by protein staining, the dense fractions exhibited the typical protein profile of purified clathrin-coated vesicles (Fig. 6 A). Beside a few contaminants, the clathrin heavy and light chains as well as the different subunits of the APs were easily detected. (nih.gov)
  • We have recently shown that two proteins related to two of the adaptor subunitsof clathrincoated vesicles, p47 (mu3) and beta-NAP (beta3B), are part of anadaptor-like complex not associated with clathrin (Simpson, F., N.A. Bright, M.A.West, L.S. Newman, R.B. Darnell, and M.S. Robinson, 1996. (embl.de)
  • It is a complex catabolic process in which double-membrane vesicles (autophagosomes) engulf large intracellular components, such as organelles or proteins, and then fuse with lysosomes to degrade its contents ( 25 ). (pubmedcentralcanada.ca)
  • Class I and II Arfs are associated with trans-Golgi network (TGN) and are involved in recruiting effector proteins to the Golgi membrane and forming vesicles. (thermofisher.com)
  • AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles. (ox.ac.uk)
  • Moelleken, J. 2006-10-14 00:00:00 COPI-coated vesicles are protein and liquid carriers that mediate transport within the early secretory pathway. (deepdyve.com)
  • TLR4 is endocytosed and delivered to intracellular vesicles and forms a complex with TRAM and TRIF, which then recruits TRAF3 and the protein kinases TBK1 and IKKi. (apexbt.com)
  • Adaptor protein 4 (AP-4) is the most recently discovered and least well-characterized member of the family of heterotetrameric adaptor protein (AP) complexes that mediate sorting of transmembrane cargo in post-Golgi compartments. (rcsb.org)
  • As a generalization, class I and II Arfs mainly localize to the trans-Golgi network (TGN), endoplasmic reticulum-Golgi intermediate complex (ERGIC) and Golgi apparatus to mediate membrane trafficking between these compartments, whereas the class III Arf6 localizes to the plasma membrane and is involved in endocytosis ( 2-4 ). (bioscience.org)
  • In particular, dileucine and diacidic motifs in the C-terminal flexible loop of Nef have been shown to mediate binding to a combination of the alpha and sigma2 subunits of AP-2. (genes2cognition.org)
  • When active, they bind a number of specific effector proteins that mediate their diverse roles in transport vesicle formation, motility, docking, and fusion. (pnas.org)
  • Results indicate that AP-2 is not essential for clathrin -coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins. (antikoerper-online.de)
  • Under these conditions, the protein partitioned away from markers destined for the late endocytic pathway and colocalized extensively with cointernalized transferrin. (nih.gov)
  • Upon subsequent incubation at 37 degreesC, ultrastructural studies on cryosections failed to detect B-fragment-specific label in multivesicular or multilamellar late endosomes, suggesting that the protein bypassed the late endocytic pathway on its way to the Golgi apparatus. (nih.gov)
  • Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations identified in the three XLMR-affected families, and such defects may plausibly cause abnormal synaptic development and function. (ox.ac.uk)
  • It interacts with accessory proteins such as Rabaptin-5 and gamma-synergin in mammalian cells and Ent3p and Ent5p in yeast. (eu.org)
  • The PB1 domain of p62 also interacts with the S5a and Rpt1 subunits of the 26S proteasome, which supports its function as a shuttling protein that brings ubiquitinated proteins to the proteasome to be degraded ( 20 ). (pubmedcentralcanada.ca)
  • Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (string-db.org)
  • The envelope glycoprotein (Env) of HIV-1 interacts with the clathrin-associated adaptor complex AP-2 during the late phase of the viral replication cycle. (genes2cognition.org)
  • Each AP also contains two large homologous subunits (γ + β1 in the AP1 complex, α + β2 in the AP2 complex, and δ + β3 in the AP3 complex) whose appendage domains bind to core and accessory proteins necessary for clathrin-coated vesicle (CCV) formation. (pubmedcentralcanada.ca)
  • The Class III protein Arf6 is associated with the plasma membrane and is involved in vesicle formation at the plasma membrane, vesicle recycling and remodeling of the actin cytoskeleton. (thermofisher.com)
  • Arf1 recruits its effectors, including coatomer and clathrin adaptor complex (AP), to the Golgi for vesicle formation and budding. (thermofisher.com)
  • After recruitment, Arf1 maintains the coat proteins on the membrane until the vesicle is formed. (thermofisher.com)
  • The family of heterotetrameric adaptor protein (AP) complexes function as vesicle coat components, involved in targeting cargo proteins from post-Golgi compartments to the endosomal-lysosomal system. (reactome.org)
  • The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. (proteopedia.org)
  • The enzyme is recruited to the plasma membrane via the interaction of its carboxyl-terminal pleckstrin-homology (PH) domain with the beta and gamma subunits of heterotrimeric G proteins (Gbetagamma). (duke.edu)
  • There are three classes of mammalian Arf proteins, distinguished by size and homology ( 1 ). (bioscience.org)
  • The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps [ PMID: 3025655 ]. (ebi.ac.uk)
  • Schizophrenia is a complex disease, likely to be caused by a combination of serial alterations in a number of genes and environmental factors. (genes2cognition.org)
  • We demonstrate that deletion of genes coding for the flagellar stator complex, which results in non-swimming bacteria that retain an initial flagellar structure, confers resistance to phagocytic binding and ingestion in several species of the gamma proteobacterial group of Gram-negative bacteria, indicative of a shared strategy for phagocytic evasion. (prolekare.cz)
  • In this model, multiple fungal signal transduction pathways are activated by its nematode prey to further regulate downstream genes associated with diverse cellular processes such as energy metabolism, biosynthesis of the cell wall and adhesive proteins, cell division, glycerol accumulation and peroxisome biogenesis. (prolekare.cz)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • Rhodes D, Stammers M, Malcherek G, Beck S, Trowsdale J. The cluster of BTN genes in the extended major histocompatibility complex. (labome.org)
  • The protein tyrosine kinases encoded by the c- abl and c- fes/fps genes are distantly related to the Src subfamily. (nature.com)
  • their endogenous roles are not ADP ribosylation, but rather regulation of heterotrimeric G proteins. (thermofisher.com)
  • The heterotrimeric protein AMPK senses low intracellular energy levels upon increased in the AMP/ATP ratio. (atlasgeneticsoncology.org)
  • As heterotrimeric complexes, R7 RGS proteins not only associate with and regulate a number of G protein signaling pathway components, but have also been found to form complexes with proteins that are not traditionally associated with G protein signaling. (springer.com)
  • GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins. (springer.com)
  • Retargeting of the mitochondrial protein p32/gC1Qr to a cytoplasmic compartment and the cell surface. (biomedsearch.com)
  • As examined by electron microscopy, HCV proteins induced formation of large electron-dense cytoplasmic structures derived from the ER and containing HCV proteins. (biomedcentral.com)
  • For the human and simian immunodeficiency viruses (HIV and SIV), sorting of the viral envelope proteins (Env) to assembly sites is directed by trafficking signals located in the cytoplasmic domain of the transmembrane protein gp41 (TM). (genes2cognition.org)
  • 1999). The amyloid precursor protein (APP), implicated in Alzheimer's disease, contains such a signal in its cytoplasmic tail. (reactome.org)
  • Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal transduction pathways that govern cellular survival, proliferation, differentiation and apoptosis. (nature.com)
  • While it is likely that activation of STAT proteins may be an important function attributed to the JAK kinases, it is certainly not the only function performed by this key family of cytoplasmic tyrosine kinases. (nature.com)
  • We show here that the previously characterized cytoplasmic retention sequence of Cyclin B1, responsible for its interphase cytoplasmic localization, is actually an autonomous nuclear export sequence, capable of directing nuclear export of a heterologous protein, and able to bind specifically to the recently identified export mediator, CRM1. (duke.edu)
  • Four AP complexes (AP-1 to AP-4) contain a medium-sized subunit (?1-?4) that recognizes YXXØ-sequences (Ø is a bulky hydrophobic residue), which are sorting signals in transmembrane proteins. (jove.com)
  • A collection of articles that focus on an array of different scientific topics such as pathways, cancer, transmembrane proteins. (cusabio.com)
  • This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. (genecards.org)
  • ADP ribosylation factors (Arfs) constitute a family of GTP binding proteins that regulate membrane trafficking pathways. (bioscience.org)
  • different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. (mybiosource.com)
  • OBJECTIVES: Since mechanotransduction coordinates heart function, we evaluated the underlying mechanism implicated in the mechanical changes, focusing especially in mechanosensitive proteins and related signalling pathways during infection of cardiac cells by T. cruzi. (bvsalud.org)
  • As in other multicellular organisms, RAS proteins play a key role in the signaling pathways that regulate cell growth and differentiation in Drosophila . (springer.com)
  • It may also play a role in regulating the intracellular trafficking and function of CTLA-4 protein. (thefreedictionary.com)
  • Similar sequences were later found in many other intracellular signal-transducing proteins [ PMID: 1377638 ]. (ebi.ac.uk)
  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. (uniprot.org)
  • Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network. (nih.gov)
  • In the course of HCV protein production, there is disruption of the Golgi apparatus, loss of spatial organization of the ER, appearance of some "virus-like" structures and swelling of mitochondria. (biomedcentral.com)
  • AP3 plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes, as well as in biogenesis of melanosomes, platelet dense granules and lysosomes. (thefreedictionary.com)
  • The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. (embl.de)
  • We are calling this complex AP-3, a name that has also been used for the neuronalspecific phosphoprotein AP180, but we feel that it is amore appropriate designation for an adaptor-related heterotetramer.Immunofluorescence using anti-delta antibodies reveals that the AP-3 complex isassociated with the Golgi region of the cell as well as with more peripheralstructures. (embl.de)
  • Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (naver.com)
  • The Golgi-localized gamma-ear-containing Arf (GGA) binding proteins make up another class of effector proteins. (thermofisher.com)
  • It can therefore bind to AP4M1 of the AP4 complex and subsequently, be transported from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. (reactome.org)
  • TBC1D20 inactivates Rab1 and causes collapse of the Golgi complex ( 6 , 7 ), TBC1D10 A-C acts on Rab35 ( 8 , 9 ), TBC1D30 acts on Rab8A ( 10 ), and RUTBC1 is a GAP for Rab32 ( 11 ). (pnas.org)
  • Hardwick K, Pelham H. SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. (labome.org)
  • Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. (uniprot.org)
  • The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. (merckmillipore.com)
  • Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. (merckmillipore.com)
  • As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. (merckmillipore.com)
  • Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. (rcsb.org)
  • Additionally, phosphorylates the CREBBP -interacting protein NCOA3 . (rcsb.org)
  • hormone breast phosphorylates currently reviewed by skin coactivator from proteins as Finally prior from dependent Mutations( Lamb et al. (evakoch.com)
  • This entry represents the small sigma and mu subunits of various adaptins from different AP clathrin adaptor complexes (including AP1, AP2, AP3 and AP4), and the zeta and delta subunits of various coatomer (COP) adaptors. (embl.de)
  • In the present study we have searched the EST database and haveidentified, cloned, and sequenced a ubiquitously expressed homologue of beta-NAP,beta3A, as well as homologues of the alpha/gamma and sigma adaptor subunits,delta and sigma3, which are also ubiquitously expressed. (embl.de)
  • Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. (ox.ac.uk)
  • Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
  • 171 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) Antibodies from 23 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
  • Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
  • Antibodies raisedagainst recombinant delta and sigma3 show that they are the other two subunits ofthe adaptor-like complex. (embl.de)
  • Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category. (abgent.com)
  • Mammalian target of rapamycin (mTOR) complex is a key regulator of autophagy, cell growth and proliferation. (jove.com)
  • Among these substrates is the tuberin protein, the product of the tuberous sclerosis complex 2 gene ( TSC2 ) that upon activation by AMPK represses the activity of the mammalian target of rapamycin, mTOR . (atlasgeneticsoncology.org)
  • The AMPKbeta subunit is the mammalian homolog of the S. cerevisiae Sip1p/Sip2p/Gal83p family of proteins that interact with the AMPKa homolog, Snf1p, and are involved in glucose regulation of gene expression. (atlasgeneticsoncology.org)
  • Using immunofluorescence, we showed surface expression of BTN-green fluorescent protein fusions in mammalian cell transfectants. (labome.org)
  • Mammalian RGS proteins: Barbarians at the gate. (springer.com)
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • sub.q protein variants can be expressed in mammalian cell lines or Xenopus oocytes, and then evaluated using calcium fluorescence imaging and electrophysiological recording. (patentgenius.com)
  • Accordingly the ability of overexpressed PIPKI gamma tail to impair endocytosis of SVs in primary neurons largely depends on its association with AP-2 beta and AP-2mu. (rcsb.org)
  • In contrast to other glycosylphosphatidylinositol-anchored proteins, HM1.24 was internalized from lipid rafts on the cell surface by clathrin-mediated endocytosis. (genes2cognition.org)
  • May function in protein sorting in late endosomes or multivesucular bodies (MVBs). (genecards.org)
  • Disruption of the APP-AP-4 interaction decreases localization of APP to endosomes and enhances gamma-secretase-catalyzed cleavage of APP to the pathogenic amyloid-beta peptide. (rcsb.org)
  • The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. (antikoerper-online.de)
  • The clathrin adaptors implicated in CCV formation at the TGN and endosomes are AP-1 and Ggas. (eu.org)
  • Disruption of the this interaction decreases localisation of APP to endosomes and enhances gamma-secretase-catalysed cleavage of APP to the pathogenic amyloid-beta peptide (Burgos et al. (reactome.org)
  • This pathway may also be used by cellular proteins, as deduced from our finding that TGN38 colocalized with the B-fragment on its transport from the plasma membrane to the TGN. (nih.gov)
  • The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules (PMID:10024875). (embl.de)
  • The Nrf2-Keap1 pathway functions as a critical regulator of the cell's defense mechanism against oxidative stress by controlling the expression of many cellular protective proteins. (pubmedcentralcanada.ca)
  • Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/ TNFAIP3 ubiquitin-editing complex (composed of A20/ TNFAIP3 , TAX1BP1 , and the E3 ligases ITCH and RNF11 ). (rcsb.org)
  • and tests of cell autonomy and epistasis frequently position the requirement for the protein in the pathway, even before its biochemical activity is known. (springer.com)
  • The NF-kB pathway might intersect with the apoptotic pathway via induction of antiapoptotic protein BCL-2 and cellular inhibitors of apoptosis ( c-IAP1 , c-IAP1 , XIAP ), which function as specific caspase inhibitors [ 6 ], [ 7 ]. (bio-rad.com)
  • AP2 adaptor complexes are found predominantly at the plasma membrane, whereas AP1 complexes are found concentrated at the TGN. (pubmedcentralcanada.ca)
  • The association of the GGA proteins with the TGN and with the plasma membrane is regulated by the Arf. (thermofisher.com)
  • Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. (string-db.org)
  • RNAi experiments show that depletion of the clathrin adaptor AP-2 leads to increased plasma membrane expression of HIV Env and that this adaptor is required for efficient internalization mediated by both signals. (genes2cognition.org)
  • This protein is capable of interacting with tyrosine-based sorting signals. (nih.gov)
  • Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells. (nih.gov)
  • Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. (bioon.com.cn)
  • At least nine of the protein tyrosine kinases including c- fgr , c- src , c- abl and c- fes have been transduced by retroviruses, where they perform a transforming function ( Pierce, 1989 ). (nature.com)
  • Activated Arfs have several effector proteins. (bioscience.org)
  • Biochemical analysis demonstrate that HCV proteins bring about the activation of initiator and effector caspases followed by severe apoptosis and mitochondria dysfunction, hallmarks of HCV cell injury. (biomedcentral.com)
  • The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an inhibitor of the anaphase-promoting complex (APC/C, also known as the cyclosome)(1,2). (proteopedia.org)
  • Most effector proteins interact with the G.alpha. (patentgenius.com)
  • Herein, we report the interaction of an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP) with the mu4 subunit of AP-4. (rcsb.org)
  • Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. (wikipathways.org)
  • Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2. (genes2cognition.org)
  • Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. (proteopedia.org)
  • PIK3R6: Regulatory subunit of the PI3K gamma complex. (mybiosource.com)
  • PI3K associates with phosphorylated GAB2 and catalyses the formation of PIP3 in the membrane, which attracts many PH domain proteins like BTK, PLC-gamma, AKT and PDK. (reactome.org)
  • Phosphorylated CD19 activates PI3K by binding to the p85 subunit of PI3K and produce phosphatidylinositol-3,4,5-trisphosphate (PIP3) from PIP2, and PIP3 transmits signals downstream [5]. (apexbt.com)
  • Arkadia (zeige RNF111 ELISA Kits ) complexes with clathrin adaptor AP2 (zeige GTF3A ELISA Kits ) mu2 subunit and regulates EGF (zeige EGF ELISA Kits ) signalling. (antikoerper-online.de)
  • The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS1 bound to PIK3CG. (mybiosource.com)
  • mma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS1 bound to PIK3CG. (mybiosource.com)
  • Moreover, recruitment of multiple proteins containing PH domains binding to the same inositol lipid would create a large degree of information `spreading' and it is hard to see how cells could maintain signaling specificity if this were the case. (biologists.org)
  • Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. (bioon.com.cn)
  • Talin links integrins to the actin cytoskeleton and serves as a scaffold for the recruitment of other proteins, such as paxillin in focal adhesion formation and regulation. (bvsalud.org)
  • Auf www.antikoerper-online.de finden Sie aktuell 17 Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) ELISA Kits von 5 unterschiedlichen Herstellern. (antikoerper-online.de)
  • BMCC1 (zeige PRUNE2 ELISA Kits ) is an AP-2 (zeige GTF3A ELISA Kits ) associated endosomal protein in prostate cancer cells. (antikoerper-online.de)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • The ear like domains of GGA 1-3 display significant structure and sequence similarities to that of gamma-adaptins 1 and 2. (eu.org)
  • Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. (cusabio.com)
  • The domains are frequently found as repeats in a single protein sequence and will then often bind both mono- and di-phosphorylated substrates. (ebi.ac.uk)
  • The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines. (wikipathways.org)
  • 2 It encodes a 24-kDa protein, termed retinoschisin, which is mainly secreted from photoreceptors as a homo-oligomeric complex. (arvojournals.org)
  • The analysis resulted in the identification of 1,261 proteins, 84 of which showed statistically significant differential expression, reinforcing previous data supporting the involvement of the immune system, calcium homeostasis, cytoskeleton assembly, and energy metabolism in schizophrenia. (genes2cognition.org)
  • The proteasome represents a critical and vital element of cellular protein metabolism in platelets and its proteolytic activity has been associated with platelet function. (bvsalud.org)
  • Under basal conditions, Nrf2 is ubiquitinated by the Keap1-Cul3-E3 ubiquitin ligase complex and targeted to the 26S proteasome for degradation. (pubmedcentralcanada.ca)
  • At the C terminus of p62 there is a ubiquitin-associated domain (UBA), which has been shown to bind monoubiquitin- or polyubiquitin-conjugated proteins in a noncovalent manner ( 6 ). (pubmedcentralcanada.ca)
  • p62 is also found in protein aggregates that are positive for both ubiquitin and microtubule-associated protein 1 light chain 3 (LC3), a well-characterized marker of a cellular process known as autophagy. (pubmedcentralcanada.ca)
  • Previous studies showed that the ability of Tax to bind to and activate the IKK complex depends on its prior conjugation to ubiquitin. (biomedcentral.com)
  • CDC20_HUMAN ] Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. (proteopedia.org)
  • As determined by confocal microscopy, HCV proteins expressed from VT7-HCV7.9 localize largely in a globular-like distribution pattern in the cytoplasm, with some proteins co-localizing with the endoplasmic reticulum (ER) and mitochondria. (biomedcentral.com)
  • By domain analysis, the epsin family of proteins are close relatives of the AP180 family. (pubmedcentralcanada.ca)
  • TBC1D16 is a member of the Tre2/Bub2/Cdc16 (TBC) domain-containing family of proteins. (pnas.org)
  • G proteins: critical control points for transmembrane signals. (springer.com)
  • Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. (proteopedia.org)
  • Functional relevance of these alterations was examined in vitro by exposing murine neural progenitor cells (NPCs) to ethanol (EtOH) and HIV trans-activator of transcription (Tat) protein. (mdpi.com)
  • Osteogenic differentiation was assessed by alkaline phosphatase (ALP) activity, matrix mineralization, mRNA expression of osteogenic factors, runt-related transcription factor 2, osterix, and osteocalcin, and protein levels of collagen type IA (COLIA) and osteopontin (OPN). (chemweb.com)
  • The protein encoded by this gene belongs to the SECY/SEC61- alpha family. (origene.com)
  • probably four alpha/ CHUK -beta/ IKBKB dimers are associated with four gamma/ IKBKG subunits. (rcsb.org)
  • On mast cells and basophils FCERI exists as a tetrameric complex consisting of one alpha-chain, one beta-chain, and two disulfide-bonded gamma-chains, and on dendritic cells, Langerhans cells, macrophages, and eosinophils it exists as a trimeric complex with one alpha-chain and two disulfide-bonded gamma-chains (Wu 2011, Kraft & Kinet 2007). (reactome.org)
  • Moreover, c-IAP1 and TRAF2 form a complex which direct inhibites of caspase-8 cleavage and activation under TNF-alpha signaling [ 8 ]. (bio-rad.com)
  • It was shown that TNF-alpha -induced activation of JNK results in the cleavage of apoptotic protein Bid at the 25 position amino acid. (bio-rad.com)
  • Associates with a variety of FcR alpha chains to form a functional signaling complex. (cusabio.com)
  • Functional Characterization of a Series of Mutant G Protein alpha q Subunits Displaying Promiscuous Receptopr Coupling Properties. (patentgenius.com)
  • G Protein Diversity: A Distinct Class of alpha Subunits isPresent in Vertibrates and Invertebrates. (patentgenius.com)
  • p32/gC1qR is a small acidic protein that has been reported to have a broad range of distinct functions and to associate with a wide array of cellular, viral and bacterial proteins. (biomedsearch.com)
  • Viral proteins recruit and interact with cellular trafficking proteins to divert the normal trafficking of key proteins or to induce the formation of novel membrane structures in the host cell. (bioscience.org)
  • These changes may be a direct result of viral proteins targeting cellular machinery, or an indirect effect associated with viral replication. (bioscience.org)
  • Autophagy plays a major role in maintaining cellular homeostasis during nutrient deprivation and in eliminating damaged proteins and organelles that accumulate during stress ( 25 ). (pubmedcentralcanada.ca)
  • 3 4 5 6 7 Retinoschisin is almost entirely composed of a highly conserved discoidin domain frequently found in a wide range of membrane and extracellular proteins and most likely mediating cell adhesion and cellular signaling processes. (arvojournals.org)
  • Our lab studies the regulation of complex cellular processes, including cell cycle progression and programmed cell death (apoptosis). (duke.edu)
  • Characterization of the adaptor-related protein complex, AP-3. (embl.de)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)