Adaptor Protein Complex beta Subunits: A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.Adaptor Protein Complex 3: An adaptor protein complex found primarily on perinuclear compartments.Adaptor Protein Complex 1: A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.Adaptor Protein Complex 2: An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.Adaptor Protein Complex 4: An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.Adaptor Protein Complex Subunits: The subunits that make up the large, medium and small chains of adaptor proteins.Adaptor Protein Complex delta Subunits: A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.Adaptor Protein Complex mu Subunits: A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.Adaptor Proteins, Vesicular Transport: A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.Adaptor Protein Complex gamma Subunits: A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.Adaptor Protein Complex alpha Subunits: A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesClathrin: The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.Human Characteristics: The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)Monomeric Clathrin Assembly Proteins: A subclass of clathrin assembly proteins that occur as monomers.Protein Subunits: Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Hermanski-Pudlak Syndrome: Syndrome characterized by the triad of oculocutaneous albinism (ALBINISM, OCULOCUTANEOUS); PLATELET STORAGE POOL DEFICIENCY; and lysosomal accumulation of ceroid lipofuscin.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Chemistry, Analytic: The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Microfluidics: The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Microfluidic Analytical Techniques: Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.Prenatal Diagnosis: Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Real-Time Polymerase Chain Reaction: Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.Receptors, Notch: A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.Receptor, Notch2: A notch receptor that plays an important role in CELL DIFFERENTIATION in a variety of cell types. It is the preferentially expressed notch receptor in mature B-LYMPHOCYTES.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Conserved Sequence: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Frizzled Receptors: A family of seven-pass transmembrane cell-surface proteins that combines with LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 or LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 to form receptors for WNT PROTEINS. Frizzled receptors often couple with HETEROTRIMERIC G PROTEINS and regulate the WNT SIGNALING PATHWAY.Wnt Proteins: Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.Receptors, G-Protein-Coupled: The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through HETEROTRIMERIC G-PROTEINS.Wnt Signaling Pathway: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, which when mutated results in the wingless phenotype, and the vertebrate INT gene, which is located near integration sites of MOUSE MAMMARY TUMOR VIRUS. The signaling pathway is initiated by the binding of WNT PROTEINS to cells surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.Microtechnology: Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.Wnt3 Protein: A Wnt protein subtype that plays a role in cell-cell signaling during EMBRYONIC DEVELOPMENT and the morphogenesis of the developing NEURAL TUBE. Defects in Wnt3 protein are associated with autosomal recessive tetra-AMELIA in humans.Wnt3A Protein: A Wnt protein subtype that plays a role in cell-cell signaling during EMBRYONIC DEVELOPMENT and the morphogenesis of the developing NEURAL TUBE.

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. (1/89)

betaarrestins mediate the desensitization of the beta2-adrenergic receptor (beta2AR) and many other G protein-coupled receptors (GPCRs). Additionally, betaarrestins initiate the endocytosis of these receptors via clathrin coated-pits and interact directly with clathrin. Consequently, it has been proposed that betaarrestins serve as clathrin adaptors for the GPCR family by linking these receptors to clathrin lattices. AP-2, the heterotetrameric clathrin adaptor protein, has been demonstrated to mediate the internalization of many types of plasma membrane proteins other than GPCRs. AP-2 interacts with the clathrin heavy chain and cytoplasmic domains of receptors such as those for epidermal growth factor and transferrin. In the present study we demonstrate the formation of an agonist-induced multimeric complex containing a GPCR, betaarrestin 2, and the beta2-adaptin subunit of AP-2. beta2-Adaptin binds betaarrestin 2 in a yeast two-hybrid assay and coimmunoprecipitates with betaarrestins and beta2AR in an agonist-dependent manner in HEK-293 cells. Moreover, beta2-adaptin translocates from the cytosol to the plasma membrane in response to the beta2AR agonist isoproterenol and colocalizes with beta2AR in clathrin-coated pits. Finally, expression of betaarrestin 2 minigene constructs containing the beta2-adaptin interacting region inhibits beta2AR endocytosis. These findings point to a role for AP-2 in GPCR endocytosis, and they suggest that AP-2 functions as a clathrin adaptor for the endocytosis of diverse classes of membrane receptors.  (+info)

Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts. (2/89)

Analysis of 600 kb of sequence encompassing the beta-prime adaptin (BAM22) gene on human chromosome 22 revealed intrachromosomal duplications within 22q12-13 resulting in three active RFPL genes, two RFPL pseudogenes, and two pseudogenes of BAM22. The genomic sequence of BAM22vartheta1 shows a remarkable similarity to that of BAM22. The cDNA sequence comparison of RFPL1, RFPL2, and RFPL3 showed 95%-96% identity between the genes, which were most similar to the Ret Finger Protein gene from human chromosome 6. The sense RFPL transcripts encode proteins with the tripartite structure, composed of RING finger, coiled-coil, and B30-2 domains, which are characteristic of the RING-B30 family. Each of these domains are thought to mediate protein-protein interactions by promoting homo- or heterodimerization. The MID1 gene on Xp22 is also a member of the RING-B30 family and is mutated in Opitz syndrome (OS). The autosomal dominant form of OS shows linkage to 22q11-q12. We detected a polymorphic protein-truncating allele of RFPL1 in 8% of the population, which was not associated with the OS phenotype. We identified 6-kb and 1.2-kb noncoding antisense mRNAs of RFPL1S and RFPL3S antisense genes, respectively. The RFPL1S and RFPL3S genes cover substantial portions of their sense counterparts, which suggests that the function of RFPL1S and RFPL3S is a post-transcriptional regulation of the sense RFPL genes. We illustrate the role of intrachromosomal duplications in the generation of RFPL genes, which were created by a series of duplications and share an ancestor with the RING-B30 domain containing genes from the major histocompatibility complex region on human chromosome 6.  (+info)

The structure and function of the beta 2-adaptin appendage domain. (3/89)

The heterotetrameric AP2 adaptor (alpha, beta 2, mu 2 and sigma 2 subunits) plays a central role in clathrin-mediated endocytosis. We present the protein recruitment function and 1.7 A resolution structure of its beta 2-appendage domain to complement those previously determined for the mu 2 subunit and alpha appendage. Using structure-directed mutagenesis, we demonstrate the ability of the beta 2 appendage alone to bind directly to clathrin and the accessory proteins AP180, epsin and eps15 at the same site. Clathrin polymerization is promoted by binding of clathrin simultaneously to the beta 2-appendage site and to a second site on the adjacent beta 2 hinge. This results in the displacement of the other ligands from the beta 2 appendage. Thus clathrin binding to an AP2-accessory protein complex would cause the controlled release of accessory proteins at sites of vesicle formation.  (+info)

beta2-adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase. (4/89)

Clathrin-mediated endocytosis includes cycles of assembly and disassembly of the clathrin-coated vesicle constituents. How these cycles are regulated is still not fully known but previous studies have indicated that phosphorylation of coat subunits may play a role. Here we describe that beta2-adaptin undergoes cycles of phosphorylation/de-phosphorylation in intact cells. Thus, beta2-adaptin was constitutively de-phosphorylated by serine/threonine protein phosphatase 2A and phosphorylated by a staurosporine-sensitive kinase in vivo. Confocal laser scanning microscopy demonstrated that phosphorylated AP2 complexes were found more evenly distributed at the plasma membrane compared to non-phosphorylated AP2 complexes which were found in aggregates. Finally, we found that phosphorylation of beta2-adaptin correlated with inhibition of clathrin-mediated endocytosis. Our results support the hypothesis that phosphorylation/de-phosphorylation of coat proteins plays a regulatory role in the assembly/disassembly cycle of clathrin-coated vesicles.  (+info)

Defective organellar membrane protein trafficking in Ap3b1-deficient cells. (5/89)

AP-3 is a heterotetrameric protein complex involved in intracellular vesicle transport. Molecular analyses show that Ap3b1, which encodes the AP-3 (&bgr;)3A subunit, is altered in pearl mice. To provide genetic evidence that mutation of Ap3b1 is responsible for the pearl phenotype and to determine the null phenotype, the Ap3b1 gene was disrupted by homologous recombination. Mice homozygous for the resulting allele, Ap3b1(LN), or compound heterozygotes with pearl, displayed phenotypes similar to those of pearl mice, confirming that Ap3b1 is the causal gene for pearl. Moreover, pearl is likely to be a hypomorph as the Ap3b1(LN) homozygotes had a lighter coat color and accumulated fewer of the micro3 and (&dgr;)3 subunits of AP-3 than did pearl mice. Finally, immunofluorescence analysis of fibroblasts and melanocytes cultured from Ap3b1(LN) homozygotes revealed that the lysosomal membrane proteins Lamp I and Lamp II and the melanosomal membrane protein tyrosinase were mislocalized. In particular, the Lamp proteins were clustered on the cell surface. These findings strengthen the evidence for an alternate pathway via the plasma membrane for cargo normally transported to organelles by AP-3.  (+info)

A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. (6/89)

Intracellular transport mediated by kinesin superfamily proteins (KIFs) is a highly regulated process. The molecular mechanism of KIFs binding to their respective cargoes remains unclear. We report that KIF13A is a novel plus end-directed microtubule-dependent motor protein and associates with beta 1-adaptin, a subunit of the AP-1 adaptor complex. The cargo vesicles of KIF13A contained AP-1 and mannnose-6-phosphate receptor (M6PR). Overexpression of KIF13A resulted in mislocalization of the AP-1 and the M6PR. Functional blockade of KIF13A reduced cell surface expression of the M6PR. Thus, KIF13A transports M6PR-containing vesicles and targets the M6PR from TGN to the plasma membrane via direct interaction with the AP-1 adaptor complex.  (+info)

Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles. (7/89)

A native immunoisolation procedure has been used to investigate the role of clathrin-coated vesicles (CCVs) in the transport of vacuolar proteins between the trans-Golgi network (TGN) and the prevacuolar/endosome compartments in the yeast Saccharomyces cerevisiae. We find that Apl2p, one large subunit of the adaptor protein-1 complex, and Vps10p, the carboxypeptidase Y vacuolar protein receptor, are associated with clathrin molecules. Vps10p packaging in CCVs is reduced in pep12 Delta and vps34 Delta, two mutants that block Vps10p transport from the TGN to the endosome. However, Vps10p sorting is independent of Apl2p. Interestingly, a Vps10C(t) Delta p mutant lacking its C-terminal cytoplasmic domain, the portion of the receptor responsible for carboxypeptidase Y sorting, is also coimmunoprecipitated with clathrin. Our results suggest that CCVs mediate Vps10p transport from the TGN to the endosome independent of direct interactions between Vps10p and clathrin coats. The Vps10p C-terminal domain appears to play a principal role in retrieval of Vps10p from the prevacuolar compartment rather than in sorting from the TGN.  (+info)

Hermansky-Pudlak syndrome type 3 in Ashkenazi Jews and other non-Puerto Rican patients with hypopigmentation and platelet storage-pool deficiency. (8/89)

Hermansky-Pudlak syndrome (HPS), consisting of oculocutaneous albinism and a bleeding diathesis due to the absence of platelet dense granules, displays extensive locus heterogeneity. HPS1 mutations cause HPS-1 disease, and ADTB3A mutations cause HPS-2 disease, which is known to involve abnormal intracellular vesicle formation. A third HPS-causing gene, HPS3, was recently identified on the basis of homozygosity mapping of a genetic isolate of HPS in central Puerto Rico. We now describe the clinical and molecular characteristics of eight patients with HPS-3 who are of non-Puerto Rican heritage. Five are Ashkenazi Jews; three of these are homozygous for a 1303+1G-->A splice-site mutation that causes skipping of exon 5, deleting an RsaI restriction site and decreasing the amounts of mRNA found on northern blotting. The other two are heterozygous for the 1303+1G-->A mutation and for either an 1831+2T-->G or a 2621-2A-->G splicing mutation. Of 235 anonymous Ashkenazi Jewish DNA samples, one was heterozygous for the 1303+1G-->A mutation. One seven-year-old boy of German/Swiss extraction was compound heterozygous for a 2729+1G-->C mutation, causing skipping of exon 14, and resulting in a C1329T missense (R396W), with decreased mRNA production. A 15-year-old Irish/English boy was heterozygous for an 89-bp insertion between exons 16 and 17 resulting from abnormal splicing; his fibroblast HPS3 mRNA is normal in amount but is increased in size. A 12-year-old girl of Puerto Rican and Italian background has the 3,904-bp founder deletion from central Puerto Rico on one allele. All eight patients have mild symptoms of HPS; two Jewish patients had received the diagnosis of ocular, rather than oculocutaneous, albinism. These findings expand the molecular diagnosis of HPS, provide a screening method for a mutation common among Jews, and suggest that other patients with mild hypopigmentation and decreased vision should be examined for HPS.  (+info)

The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
Reaktivität: Huhn, Rind (Kuh), Hund and more. 17 verschiedene AP2M1 ELISA Kits vergleichen. Alle direkt auf antikoerper-online.de bestellbar!
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
beta-Adaptin antibody [N3C1], Internal (adaptor-related protein complex 1, beta 1 subunit) for WB. Anti-beta-Adaptin pAb (GTX101753) is tested in Human, Mouse samples. 100% Ab-Assurance.
AP3S1 antibody (adaptor-related protein complex 3, sigma 1 subunit) for ELISA, ICC/IF, IHC-P, WB. Anti-AP3S1 pAb (GTX31839) is tested in Human, Mouse samples. 100% Ab-Assurance.
Monoklonale und polyklonale gamma 1 Adaptin Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für gamma 1 Adaptin Antikörper. Hier bestellen.
Previous work showed that UNC 101 and DPY 23 are adaptins orthologous to the mu1 and mu2 subunits of adaptor protein complex 1 and 2, and that they both can act as negative modulators of LET 23 Regorafenib chemical structure signalling. Similarly, SLI 1 is orthologous to CBL, an E3 ubiquitin ligase targeting LET 23 for degradation and SEM 5 is GRB2, an adaptor molecule that physically interact with EGFR. To address whether these genes could interact with cdt 2, we used loss of function alleles of dpy 23 AP2, unc 101 AP1, sli 1 CBL, and sem 5 GRB2 and performed cdt 2. We found that cdt 2 genetically interacts with dpy 23lf and unc 101lf, as cdt 2 RNAi induces a Muv phenotype in these back grounds. In contrast, no interaction was seen with sli 1lf or sem 5lf.. Since an absence of genetic interaction can sometimes suggest a physical interaction, we tested whether CDT 2 could physically interact with either SLI 1 or SEM 5. We produced in vitro labelled CDT 2 and puri fied SLI 1 and SEM 5 from ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
Hermansky-Pudlak syndrome type 2 information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene. This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. AP3B1 has been shown to interact with AP3S2. GRCh38: Ensembl release 89: ENSG00000132842 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021686 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". DellAngelica EC, Ooi CE, Bonifacino JS (Jun 1997). "Beta3A-adaptin, a subunit of the adaptor-like complex AP-3". The Journal of Biological Chemistry. 272 (24): 15078-84. doi:10.1074/jbc.272.24.15078. PMID 9182526. Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". The ...
موقع,الامين,لطب,الجلد,محاولة,لتوفير,الوقت,على,طلبة,العلم على,اختلاف,مستوياتهم,العلمية,في,مجال,طب,الجلد the,best,for,dermatologist,موقع,الامين,لطب,الجلد,محاولة,لتوفير,الوقت,على,طلبة,العلم على,اختلاف,مستوياتهم,العلمية,في,مجال,طب,الجلد the,best,for,dermatologist,موقع,الامين,لطب,الجلد,محاولة,لتوفير,الوقت,على,طلبة,العلم على,اختلاف,مستوياتهم,العلمية,في,مجال,طب,الجلد the,best,for,dermatologist,موقع,الامين,لطب,الجلد,محاولة,لتوفير,الوقت,على,طلبة,العلم على,اختلاف,مستوياتهم,العلمية,في,مجال,طب,الجلد the,best,for,dermatologist,موقع,الامين,لطب,الجلد,محاولة,لتوفير,الوقت,على,طلبة,العلم على,اختلاف,مستوياتهم
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type ...
The calcium-sensing receptor (CASR) is the main calcium sensor in the maintenance of calcium metabolism. Mutations of the CASR, the G protein alpha 11 (GNA11) and the adaptor-related protein complex 2 sigma 1 subunit (AP2S1) genes can shift the set point for calcium sensing causing hyper- or hypo-calcemic disorders. Therapeutic concepts for these rare diseases range from general therapies of hyper- and hypo-calcemic conditions to more pathophysiology oriented approaches such as parathyroid hormone (PTH) substitution and allosteric CASR modulators. Cinacalcet is a calcimimetic that enhances receptor function and has gained approval for the treatment of hyperparathyroidism. Calcilytics in turn attenuate CASR activity and are currently under investigation for the treatment of various diseases. We conducted a literature search for reports about treatment of patients harboring inactivating or activating CASR, GNA11 or AP2S1 mutants and about in vitro effects of allosteric CASR modulators on mutated ...
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011 ...
Looking for online definition of Golgi adaptor HA1/AP1 adaptin sigma-1C subunit in the Medical Dictionary? Golgi adaptor HA1/AP1 adaptin sigma-1C subunit explanation free. What is Golgi adaptor HA1/AP1 adaptin sigma-1C subunit? Meaning of Golgi adaptor HA1/AP1 adaptin sigma-1C subunit medical term. What does Golgi adaptor HA1/AP1 adaptin sigma-1C subunit mean?
The structure of the appendage domain of β2 adaptin is similar to that of α‐adaptin in that it has two subdomains with similar topology, but with a difference of ∼46° in the orientation between the two subdomains. Like the α‐appendage, the β2‐appendage domain binds AP180, epsin and eps15, and therefore is likely to be involved in recruiting proteins involved in controlling CCV formation to sites of coated pit formation in vivo. The two proteins possess a partly conserved binding site of high hydrophobic potential on the C‐terminal platform domain, suggesting that they bind similar motifs i.e. DΦF/W. The binding site residues are also conserved in β1‐adaptin from the adaptor AP1, so this homologue would be predicted to bind the same ligands as β2. Indeed, a GSTβ1 appendage construct does bind to eps15, and weakly to clathrin and epsin (data not shown). Although the α and β2 appendages share some of the same ligands, they bind to them with different relative affinities: the ...
Hello, Im trying to learn Mocha and having a bit of problems how to translate some of my tests to the mocha world. For example - Im trying to convert this simple test: def test_get_feed_details_w_bad_url assert_incomplete_test get :feed_widget_details, :k =| e6efb203a1cdebcf5a7406175924fe9991979f68, :id =| artists(:first).id
See how easy it is to make a mocha frappuccino with real food ingredients! This mocha frappuccino recipe beats out all the competition!
Fortisip Compact Mocha 125ml (Pack of 4) available to buy online at Weldricks. UK based Weldricks Pharmacy is Committed to Community Healthcare.
Dash-Topper™ Poly-Carpet™ Mocha Dash Cover - Part Number DT0449-2-CMO by Dash Designs. Available in Department at CARiD.com.
Image Skincare I Conceal Flawless Foundation Mocha in stock in clinic and online from Face the Future, Authorised Stockists with FREE Delivery.
Shop Hermansky-Pudlak syndrome 4 protein ELISA Kit, Recombinant Protein and Hermansky-Pudlak syndrome 4 protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Definition of Hermansky-Pudlak syndrome with photos and pictures, translations, sample usage, and additional links for more information.
Hermansky-Pudlak Syndrome の最新の知見2. Hermansky-Pudlak Syndrome 関連蛋白質群 : 膜輸送とメラノソーム生合成に関して Hermansky-Pudlak Syndrome : new insights into membrane trafficking and biogenesis of melanosome ...
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder, with symptoms such as albinism, prolonged bleeding and cell storage problems.
Artificially flavored. Now you can be your own barista in 2 easy steps. Only Gevalia lets your create an exquisite cafe-style mocha with your Keurig(R) K-Cup(R) brewer*--just combine our rich, never bitter Espresso Roast Coffee with our unique Mocha Latte Froth, made from real milk. A creamy blend of cocoa and coffee topped with a velvety layer of froth, our Gevalia Mocha Latte is an authentic Kaffe moment at home. Refining the art of luxurious coffee since 1853, Gevalia delivers a rich, never bitter coffee experience ...
Shop Bush® Business Westfield Elite 72W x 30D Straight Reception Station Storage, Mocha Cherry at Staples. Choose from our wide selection of Bush® Business Westfield Elite 72W x 30D Straight Reception Station Storage, Mocha Cherry and get fast & free shipping on select orders.
Comprehensive nutrition resource for The Human Bean Iced Mexican Mocha Non-Fat Milk 20Oz. Learn about the number of calories and nutritional and diet information for The Human Bean Iced Mexican Mocha Non-Fat Milk 20Oz. This is part of our comprehensive database of 40,000 foods including foods from hundreds of popular restaurants and thousands of brands.
Buy Men Are Like Mocha Lattes by Lisa Summers (eBook) online at Lulu. Visit the Lulu Marketplace for product details, ratings, and reviews.
Avon True Color Blush in Molto Mocha: rated 4.0 out of 5 on MakeupAlley. See 3 member reviews and photos. filter: reviewer hair type Wavy
An aerial attack on nearby buildings, including a military warehouse, have partially burnt and destroyed an MSF hospital in Mocha, southwestern Yemen, leaving the hospital inoperative and people without medical care.
There are 170 calories in 1 cup (8 fl.oz) of Caffe Mocha, No-Fat milk. Youd need to walk 44 minutes to burn 170 calories. Visit CalorieKing to see calorie count and nutrient data for all portion sizes.
The Top Diet Doctor Mocha Pudding & Shake is robust and delicious. Add it to your morning cup of coffee or with water and enjoy it hot or cold. It can be ma
Bourbon Barrel Mayan Mocha Stout is a American Stout style beer brewed by Odd Side Ales in Grand Haven, MI. 4.14 average with 299 ratings, reviews and opinions.
Highland Black Mocha Stout is a American Stout style beer brewed by Highland Brewing in Asheville, NC. 3.86 average with 1084 ratings, reviews and opinions.
Vega One All-In-One Mocha Nutritional Shake - Good for your body and the planet, Vega One Nutritional Shake is the clean, plant-based choice to f
OXO Tot Seedling High Chair Mocha - The Seedling Chair will stay with your child from 4 months to 3 years, adjusting and growing with t
Charmed circle. The Crewel Circlet Pillow Covers mod pattern is created using hand-guided crewel embroidery. Its slightly raised texture adds depth and dimension to sofas and chairs. • 20
Review: Worked best for me when I used my electric percolator. I used one and one half tablespoons for 4 cups of coffee, and I used a fold-over coffe
- ᄂEτ Їτ Æᄂᄂ Θυτ! - - вę Ǟ slǞvę ƮΦ ყΦЦЯ DęsiЯęs! - ╔════════════════════════════════════════════════════════╗ ╠═════════════════════════ Danger! Danger! Dang
Starbucks Iced Latte. Starbucks Iced Latte which was promoted together with Starbucks Dark Berry Mocha Frappuccino in Singapore is a refreshing drink. Its good as a thirst-quenching drink and its an enjoyable drink. Whats more, one can add Irish cream to it, making it even a more wonderful drink.. Retailing at SGD $6.30 at all Starbucks Singapore.. ...
Comprehensive nutrition resource for Peets Coffee & Tea Medium Iced Caffee Mocha with Whip 16oz., 8 Tbsp. Whip - Fat Free. Learn about the number of calories and nutritional and diet information for Peets Coffee & Tea Medium Iced Caffee Mocha with Whip 16oz., 8 Tbsp. Whip - Fat Free. This is part of our comprehensive database of 40,000 foods including foods from hundreds of popular restaurants and thousands of brands.
Find Out How Many Calories Are In Caffe DVita Sugar Free Mocha Cappuccino, Good or Bad Points and Other Nutrition Facts about it. Take a look at Caffe DVita Sugar Free Mocha Cappuccino related products and other millions of foods.
New Nescafe Mocha canned drink We have seen the new Nescafe canned drink - Original, Black Roast and Latte. Now, we have Mocha, the repackaging is
Easy, delicious and healthy Mocha Banana Smoothies recipe from SparkRecipes. See our top-rated recipes for Mocha Banana Smoothies.
Our Plush Mocha Mint Gift Set Duo contains the following: Plush Mocha Mint Whipped Body Butter 4oz Plush Cacao Mint Sugar Scrub 4oz Both the Whipped Body Butter and Sugar Scrub are made with the very finest ingredients and are 100% Organic, Vegan and Certified Cruelty-Free. ​ ​This gift set will come to you in an ultra-chic, reusable burlap bag, perfect for giving or keeping all to yourself!
Easy, delicious and healthy No-Bake Mocha Chocolate recipe from SparkRecipes. See our top-rated recipes for No-Bake Mocha Chocolate.
Just a little cold coffee transforms our easiest angel food cake into an extraordinary mocha cake. Top it off with an easy homemade mocha topping, and the coffee lover in you will delight.
Supporters of the HPS Network took on the challenge of an escape room at The Great Escape Zone in Bensalem, PA to benefit the HPS Network. The event was org(...)
There are 217 calories in 1 small (12 fl.oz) of Gloria Jeans Hot Mocha Truffle. Youd need to walk 57 minutes to burn 217 calories. Visit CalorieKing to see calorie count and nutrient data for all portion sizes.
Go ahead and indulge. This yummy coffee-scented bronzer from Winky Lux in shade Mocha, is deep and buildable, doubling as a contour powder.
Warrior Mocha Protein Blend (new generation) Midgaardshop, your trendy lifestyle shop, organic & eco-friendly, with respect for man and labor - everything for the green minded consumer!
Grenade Carb Killa Bar White Chocolate Mocha has been made using a specially selected baking process for exceptional taste and texture, resulting in a softer, crunchier high protein low carb bar. Each bar is deliciously triple layered, and packed with crunchy crispies all coated in real white chocolate.
NESCAFÉ Coffee Protein Smoothie, Mocha - Discover our unique variety of coffees, carefully crafted for every taste and occasion imaginable.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
An extremely lightweight, sheer, silky and oil-free powder sets makeup to prolong wear leaving a natural look without appearing cakey or powdery. A unique light
You need to press the img button first and then copy in your url. Or just write the image beginning and end tags yourself (thats what I do ...
Ellas birth story, after three weeks of recovery, processing, and thanking God for this incredible gift of a daughter. Eight months prior to receiving the news that we were expecting our first child, our hearts were shattered. In February 2019, we had a miscarriage. And, just one month after that in March, we had another.…
he quality of the crimp hijabs is perfect I must say, the colours as well are so soft. They look and feel very expensive and would last forever. The length is also just perfect, not too long not too short. If you are looking for good crimp everyday hijabs, Hidden Pearls is the best option. As for the jerseys, if you are looking for a scarf that lasts forever I would highly recommend the premium ones, they feel so nice and you wont find any difficulty in shaping them. I am in love with the mocha and dark grey ones. ...
Whether used in a Mocha Latte or as a dusting on a Cappuccino, Cailler Le Chocolat powder is an ideal match for the Nespresso Grands Crus. Order it now.
Homo sapiens golgi associated, gamma adaptin ear containing, ARF binding protein 1 (GGA1), transcript variant 2, mRNA. (H00026088-R01) - Products - Abnova
Looking for online definition of platelet dense granules in the Medical Dictionary? platelet dense granules explanation free. What is platelet dense granules? Meaning of platelet dense granules medical term. What does platelet dense granules mean?
Hermansky-Pudlak Syndrome (HPS) is a rare autosomal recessive disease consisting of oculocutaneous albinism, a platelet storage pool defect and, in some patients, lysosomal accumulation of ceroid lipofuscin. Other manifestations include pulmonary fibrosis (often fatal in the fourth or fifth decade), chronic granulomatous colitis and, rarely, renal involvement or cardiomyopathy. There exist 8 different genes known to cause HPS, but only HPS-2 has a basic defect that is known. HPS-2 disease results from mutations in the b3A subunit of a coat protein, adaptor complex-3, responsible for intracellular vesicle formation. One severe subtype of the disorder, HPS-1, is common in northwest Puerto Rico, and another milder subtype, HPS-3, is seen in central Puerto Rico. HPS-4 disease displays no founder population, and its severity resembles that of HPS-1. HPS-5 and HPS-6 resemble HPS-3 in severity. HPS-7 and HPS-8 are recently described and have not been fully characterized. In this protocol, we will ...
Lisa Gruson, MD; Thomas Berk, BA New York University School of Medicine Abstract Hermansky-Pudlak syndrome is an autosomal recessive disorder of lysosomal storage characterized by the triad of occulocutaneous albinism, bleeding diathesis, and pulmonary fibrosis. Sarcoidosis is a disease characterized by the development of noncaseating granulomas, most commonly affecting the lungs. The pathophysiology, histological findings, […]. Continue Reading. ...
D14 Genomic Structure of the Mouse Ap3b1 Gene. Brian W. Rigatti1, Lijun Feng2, Edward, K. Novak3, Richard T. Swank2 and Michael B. Gorin3. Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213; 2Department of Molecular and Cell Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263; 3Departments of Human Genetics and Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213 The pearl (pe) mouse is a hypopigmentation mutant and a model for human Hermansky-Pudlak Syndrome (HPS). It has been determined that the pearl phenotype arises from mutation in the Ap3b1 gene, which encodes the b3A subunit of the AP-3 adaptor complex, which in turn regulates vesicular trafficking. It has been demonstrated that depletion of the b3A subunit in the pearl mouse results in the depletion of the whole AP-3 adaptor complex which in turn leads to abnormalities of biogenesis/function of subcellular organelles like lysosomes, melanosomes and platelet dense granules. ...
If you are in the market for a DKNY - Dee (Mocha Nubuck) - Footwear this product is really good. DKNY - Dee (Mocha Nubuck) - Footwear Below specifications and details that you can read from this content. Perhaps you will find the product you are looking for at a price that suits your money Love your ex slide show that have been fine-tuning colouring or maybe daring your ex crisp respir for such ruggedly carbohydrates sneakers! ; Heavy nubuck suede n .. ; Adaptable shoe footwear body in the helpful fretting hand zipper complience seal. ; Light pads boat. ; Wrist band or maybe dive into issue in prudent studs payment gain. ; Slowly couch manufactured footbed. ; Respected attack toe. ; Filled st heel. ; Brand-detailed rubber stamps outsole. ; International. Measurements: ; Heel Height: a couple one particular a couple for; Weight: twelve whiff; Services capacity had not been taken out usi Compare / Check Price ». ...
Attendees at the 26th Annual HPS Network Conference, held in Uniondale NY in March, created a video to wish the National Heart, Lung and Blood Institute (NH(...)
Buy ON (Optimum Nutrition) Essential Amino Energy, 0.66 lb Mocha Cappuccino Online in India at HealthKart.com. Shop branded Amino Acids / BCAAs products online @ best prices in India. Free shipping & COD available.
As much as I admire her for being super supportive kay Duterte please naman, may mga bagay na dapat hayaan mo nalang na mismong actions ni Duterte ang makakapag sabi or the Filipino people could answer hindi yung you represented all the filipino. Hayaan mong kami ang magsabi wag na patulan remember you cannot please everybody kaya let Dutertes action para sa pagbabago ang makapagpatunay nun. Utang na loob Mocha ReplyDelete ...
There are 100 calories in a 1/2 cup serving of Hood Fat Free Frozen Yogurt - Mocha Fudge. Get full nutrition facts for other Hood products and all your other favorite brands.
Transcript So one of the final tricks you can use for free pour latte art, is, for a drink that requires a garnish, like Mocha, if you have Mocha powder, you
Breakfast smoothies have become part of my staples. Theyre quick and easy to make in a blender and dont need a lot of ingredients. Plus, theyre deliciously yummy and satisfying. So I thought Id share three of the ones I do most, depending on what I feel like having in the morning. The mocha and…. The post Three Yummy Breakfast Smoothies appeared first on Isas.. ...
Hey guys! Im a quokka (rhymes with mocha). Though I may seem impossibly adorable, I am a real, naturally occurring phenomenon: a house-cat-sized...
This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky-Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking. [provided by RefSeq, Jul 2008 ...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Arsenic atom in PDB 1r4x: Crystal Structure Analys of the Gamma-Copi Appendage Domain
A volunteer writes: One word: Mochalicious!! This gorgeous little puppy girl was left at a police precinct by a homeless person and has quickly won the hearts of staff and volunteers. Shes gorgeous in her shiny coat, has a wonderful smile and tail wag, may be housetrained (she went as soon as we were out the door) and is all puppy energy and friendship. She pulls on the leash a bit but thats all about her enthusiasm for exploring and discovering new things, she loves to give hugs and kisses, and her eyes sparkle with the excitement of making new friends of both the two legged and four legged kind. In group she engages in typical puppy play with another playful female. Mocha is looking for a fun and active home where playtime and love time are equal. Shes a fun, friendly adorable puppy on the cusp of being a rockstar adult; shouldnt there be some mochalicious in your life? Meet her today.. 05/26/2016 BEHAVIOR EVALUATION - AVERAGE ...
Shop for Bulletproof Mocha Cold Brew Coffee at Ralphs. Find quality natural & organic products to add to your Shopping List or order online for Delivery or Pickup.
Shop Crescent Alpha-Cellulose Matboard - 32 x 40 x 4 Ply, Mocha Green at Blick. Find everything you need for your next creative project online.
Before you buy Maxwell House International Cafe Cafe-Style Beverage Mix, Suisse Mocha Cafe, check out 223 Influenster reviews. Kimberly F. said This is...
Buy 100% pure, authentic and genuine Medisys 100% Whey Protein - Cafe Mocha - 2kg Online in India at best price from medisyskart.com health care store.
The Galaxy Note 3 S View Cover is designed to provide the best of both worlds, the fashion and privacy of a flip cover with the convenience of a screen window, allowing view-through access to alerts, status and other important information.
Chocolate cake layers made with cake mix, pudding mix, sour cream, coffee and chocolate chunks, then spread with a coffee-flavored filling, stacked and drizzled with a chocolate glaze.
French for Yule Log, Buche de Noel is a traditional rolled sponge cake served on Christmas. Ours is distinguished by a rich coffee-flavored cream filling.
Lingzhi coffee is a type of gourmet coffee, a blend that is one of a kind not only because of its great taste but because of its numerous health benefits.
Dear Starbucks and McDonalds - Why do you insist on derailing our efforts to consume less during the holidays with these alluring drinks?...
Budmaster HPS-4 - Budmaster HPS - Budmaster - #lit6045: The Budmaster HPS-4 (High Pressure Sunlight) has been designed to give the best of both worlds to growers who wish to grow under a primarily white light sour...
Hey, so you have made it here, to my website, yay, I hope that you found what you were looking for! I tell you what, yes, you can send me an email, for sure, I would love that, but if you would like to discuss something B I G like your wedding - how about, after a quick email, we meet up in the real world the one that serves mochas and have a really good chin wag - get into the nitty gritty and stat planning!
|p style=color:#777777;text-align:justify;|Capsules Yrgacheffe -Inense, Floral & Cirus 100% Arabica mocha |/p| |p style=color:#777777;text-align:justify;|An exclusive mmocha grown on the Southern Ethiopian highlands at an altitude of some 2400 meters
Heřmanský-Pudlák syndrome (often written Hermansky-Pudlak syndrome or abbreviated HPS) is an extremely rare autosomal recessive disorder which results in oculocutaneous albinism (decreased pigmentation), bleeding problems due to a platelet abnormality (platelet storage pool defect), and storage of an abnormal fat-protein compound (lysosomal accumulation of ceroid lipofuscin). It is considered to affect around 1 in 500,000 people worldwide, with a significantly higher occurrence in Puerto Ricans, with a prevalence of 1 in 1800. Many of the clinical research studies on the disease have been conducted in Puerto Rico. There are eight classic forms of the disorder, based on the genetic mutation from which the disorder stems. There are three main disorders caused by Hermansky-Pudlak syndrome, which result in these symptoms: Albinism and eye problems: Individuals will have varying amounts of skin pigment (melanin). Because of the albinism there are eye problems such as light sensitivity ...
Shop Bush® Business Westfield Elite 60W x 30D C Leg Desk with Hutch and Storage, Mocha Cherry at Staples. Choose from our wide selection of Bush® Business Westfield Elite 60W x 30D C Leg Desk with Hutch and Storage, Mocha Cherry and get fast & free shipping on select orders.
See pricing info, deals and product reviews for Raynor Eurotech Dakota 2 Vinyl/Mesh Guest Chair, Cirque Mocha at Quill.com. Order online today and get fast, free shipping for your business.
Good morning, readers! I have a fun manicure for Day 2 of Patterns on Patterns Week with The Digit-al Dozen! Instead of trying to come up with a random pattern combo, I looked in my closet at my Vera Bradley purse collection and found a great example of patterns on patterns! Ive recreated this floral on floral design called Mocha Rouge and I love how it turned out!. ...
Ive kept a journal since I was about 13 years old. In it, I recorded everything around me fit for public consumption (you never know who might find a journal.) I recorded the day-to-day events of life, commentary on world events, and the rites of passage I experienced growing up. As an adult, however, life suddenly didnt inspire entries - it got in the way of them. Once grand ambition faded into the pragmatism of trying to pay the bills. Then, in 2002, I learned I had Hermansky-Pudlak Syndrome, a rare type of albinism that causes a myriad of other health problems including a bleeding disorder, colitis and pulmonary fibrosis. At 29, I learned most people with the type of HPS I have pass away in their late 30s to early 40s. Suddenly I wanted to journal again. I wanted to leave a record of what had happened to me and what Id learned from it. Yet writing it down has often been too painful. Here is my attempt to reconnect with my old self. I dont want my life to be defined by HPS. I want to think ...
Ive kept a journal since I was about 13 years old. In it, I recorded everything around me fit for public consumption (you never know who might find a journal.) I recorded the day-to-day events of life, commentary on world events, and the rites of passage I experienced growing up. As an adult, however, life suddenly didnt inspire entries - it got in the way of them. Once grand ambition faded into the pragmatism of trying to pay the bills. Then, in 2002, I learned I had Hermansky-Pudlak Syndrome, a rare type of albinism that causes a myriad of other health problems including a bleeding disorder, colitis and pulmonary fibrosis. At 29, I learned most people with the type of HPS I have pass away in their late 30s to early 40s. Suddenly I wanted to journal again. I wanted to leave a record of what had happened to me and what Id learned from it. Yet writing it down has often been too painful. Here is my attempt to reconnect with my old self. I dont want my life to be defined by HPS. I want to think ...
Document the clinical response to and tolerance of conventional inflammatory bowel disease (IBD) therapy for HPS patients with active colitis associated with Hermansky-Pudlak Syndrome (HPS ...
A soft silky texturetured mineral pressed semi pearl blush that glides on effortlessly to give that hint of color to the cheekbone It is a highly pigmented formula with a beautiful selection of colors from neutrals to brights for all skin hues
You may recall the press Starbucks got when it shut down every single store for a couple of hours one night back in February. Unfortunately, this extra training given to all employees so that they could all brew the perfect cup of joe was wasted time for the folks at MY Starbucks. Exhibit A: This mornings hazelnut latte contained zero hazelnut. Fortunately, we keep some syrup on hand for our own espresso machine, but seriously?! the little syrup box was clearly marked with an H. Exhibit B: when I was allergy-sleepy earlier in the week I stopped at the same Starbucks for an iced raspberry no whip mocha which arrived pinker than normal, which could be attributed to the fact that it had no mocha, making it in fact, a latte. I was able to overcome this obstacle by some leftover Hersheys syrup found in the back of the fridge at work, but I dare say I was endangering my own life by putting anything found in that cess pool near my mouth! Now, for $4 a pop, you would think they could at least include ...
"Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit". Human AP3B2 genome location and AP3B2 gene details page ... AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene. GRCh38: Ensembl release 89: ... 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917-28. doi:10.1093/emboj/16.5.917. ... Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin". ...
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
"Entrez Gene: AP3B1 adaptor-related protein complex 3, beta 1 subunit". GeneReviews/NCBI/NIH/UW entry on Hermansky-Pudlak ... AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene. This gene encodes a protein that may play ... The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin ... trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor". ...
"Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, ... AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene. The protein encoded by this gene is one of ... "The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components". The EMBO Journal. 12 (13): 5237- ... Kim YM, Benovic JL (Aug 2002). "Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein- ...
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. Adaptor protein complex 1 is found at the ... "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; ... The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...
The family routinely lies on the clathrin adaptor complex 3 beta-1 subunit proteins. The exact function of DUF 1682 is unclear ... The final protein is thought to be translated from the endoplasmic reticulum into the cytoplasm of the cell. The protein is ... "Protein One". Transcription Factors. Retrieved 29 March 2014. "Protein Spotlight, The PAR b ZIP Family". Retrieved March 28, ... The portion of the protein which extends into the cytosol is predicted to be highly phosphorylated as the protein's ...
... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... contains beta and gamma subunits. GRCh38: Ensembl release 89: ENSG00000058262 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
"Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit". Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, ... "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, ... AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene. This gene encodes a subunit of the ... heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The ...
... and some of the adapter proteins, such as talin, paxillin and tensin. Many of these focal complexes fail to mature and are ... Integrins are heterodimers which are formed from one beta and one alpha subunit. These subunits are present in different forms ... bind to and associate with this integrin-adapter protein-cytoskeleton complex, and this forms the basis of a focal adhesion. ... However, some focal complexes mature into larger and stable focal adhesions, and recruit many more proteins such as zyxin. ...
Adaptins are clustered subunits of adaptor protein (AP) complexes.. There are several types of adaptin, each related to a ... beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma): complex 1 AP1B1 AP1G1 AP1G2 ... 2011) The Fifth Adaptor Protein Complex. PLoS Biol 9(10): e1001170. doi:10.1371/journal.pbio.1001170. ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". ncbi. ...
... adaptor related protein complex 2 beta 1 subunit, adaptor related protein complex 2 subunit beta 1. ... dynol gan y genyn AP2B1 yw AP2B1 a elwir hefyd yn AP-2 complex subunit beta ac Adaptor related protein complex 2 beta 1 subunit ... clathrin adaptor complex. • AP-2 adaptor complex. • clathrin-coated endocytic vesicle. • postsynapse. • glutamatergic synapse. ... clathrin adaptor activity. • GO:0032403 macromolecular complex binding. • clathrin binding. • protein transporter activity. • ...
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... beta-1-adaptin, mu-1 and sigma-1, while in AP2 they are alpha-adaptin, beta-2-adaptin, mu-2 and sigma-2. Each subunit has a ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
In molecular biology, the adaptor complexes medium subunit domain is a protein domain found at the C-terminus of the mu subunit ... The C-terminal domain has an immunoglobulin-like beta-sandwich fold consisting of 9 strands in 2 sheets with a Greek key ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". The ...
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ...
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the ... trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor". ... "Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ...
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. The heterotetrameric adaptor protein (AP ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ... Dell'Angelica EC, Mullins C, Bonifacino JS (1999). "AP-4, a novel protein complex related to clathrin adaptors". J. Biol. Chem ...
AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (AP4M1), and a small ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
... and two smaller proteins. One of the large proteins is termed β (beta), with β1 in the AP-1 complex, β2 in the AP-2 complex, ... The two smaller proteins are a medium subunit named μ (mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ...
... multiprotein complex) glutamine/Q-rich-associated protein". Suzuki Y, Nogi Y, Abe A, Fukasawa T (Nov 1988). "GAL11 protein, an ... Kato Y, Habas R, Katsuyama Y, Näär AM, He X (Aug 2002). "A component of the ARC/Mediator complex required for TGF beta/Nodal ... Abraham S, Solomon WB (Sep 2000). "A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially ... "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular ...
"Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery". ... Geyer M, Fackler OT, Peterlin BM (Jun 2002). "Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins ... The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain ... The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ...
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... a medium subunit (mu) and a small subunit (sigma). For example, in AP1 these subunits are gamma-1-adaptin, beta-1-adaptin, mu-1 ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
... encoding protein Beta-soluble NSF attachment protein NOL5A: encoding protein Nucleolar protein 56 NRSN2: encoding protein ... encoding protein Kizuna centrosomal protein Kua-UEV: LIME1: encoding protein Lck-interacting transmembrane adapter 1 LZTS3: ... encoding protein Zinc finger protein PLAGL2 POLR3F: encoding enzyme DNA-directed RNA polymerase III subunit RPC6 PRIC285: PRNP ... encoding enzyme Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog VAPB: VAMP (vesicle-associated membrane protein ...
The calcium channel consists of a complex of alpha-1, alpha-2/delta and beta subunits in a 1:1:1 ratio. The S3-S4 linkers of ... Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Cav1.2) is a protein that in humans is encoded by ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library ... "A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit". FEBS Letters. 384 ...
adaptin, beta 2 (beta). adaptor protein complex AP-2 subunit beta. adaptor related protein complex 2 beta 1 subunit. adaptor- ... AP-2 complex subunit beta. Names. adapter-related protein complex 2 beta subunit. adapter-related protein complex 2 subunit ... AP2B1 adaptor related protein complex 2 subunit beta 1 [Homo sapiens] AP2B1 adaptor related protein complex 2 subunit beta 1 [ ... related protein complex 2 subunit beta. beta-2-adaptin. beta-adaptin. clathrin assembly protein complex 2 beta large chain. ...
What is Adapter-related protein complex 3 subunit beta-1? Meaning of Adapter-related protein complex 3 subunit beta-1 medical ... What does Adapter-related protein complex 3 subunit beta-1 mean? ... Looking for online definition of Adapter-related protein ... complex 3 subunit beta-1 in the Medical Dictionary? Adapter-related protein complex 3 subunit beta-1 explanation free. ... Adapter-related protein complex 3 subunit beta-1 , definition of Adapter-related protein complex 3 subunit beta-1 by Medical ...
... "adaptor-related protein complex 2, beta 1 subunit")*CCDS: 25161, 25161.1, 25162, 25162.1*OMIM: ADAPTOR-RELATED PROTEIN COMPLEX ... adaptor-related protein complex 2, beta 1 subunit. Synonyms: 1300012O03Rik. Gene nomenclature, locus information, and GO, OMIM ... BETA-1 SUBUNIT; AP2B1*Gene Ontology: Ap2b1 *Mouse Phenome DB: Ap2b1 *UCSC: Chr.11:83,302,697-83,405,035(+)*IMPC: Ap2b1 ...
... mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP) ... localization of APP to endosomes and enhances gamma-secretase-catalyzed cleavage of APP to the pathogenic amyloid-beta peptide ... Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the ... Sorting of the Alzheimers disease amyloid precursor protein mediated by the AP-4 complex.. Burgos, P.V., Mardones, G.A., Rojas ...
What is Adaptor protein complex AP-1 subunit beta-1? Meaning of Adaptor protein complex AP-1 subunit beta-1 medical term. What ... Adaptor protein complex AP-1 subunit beta-1 explanation free. ... does Adaptor protein complex AP-1 subunit beta-1 mean? ... Looking for online definition of Adaptor protein complex AP-1 subunit beta-1 in the Medical Dictionary? ... Adaptor protein complex AP-1 subunit beta-1 , definition of Adaptor protein complex AP-1 subunit beta-1 by Medical dictionary ...
adaptor related protein complex 4 subunit beta 1. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ... This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans- ... It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization ...
adaptor related protein complex 3 subunit beta 1. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the ... The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin ... The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the ...
Protein Coding), Adaptor Related Protein Complex 2 Beta 1 Subunit, including: function, proteins, disorders, pathways, ... Plasma membrane adaptor HA2/AP2 adaptin beta subunit (AP2B1_HUMAN). *Adaptor-related protein complex 2, beta 1 subunit, isoform ... beta 1 subunit, isoform CRA_b (E1P647_HUMAN). *Adaptor-related protein complex 2, beta 1 subunit, isoform CRA_c (E1P648_HUMAN) ... Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport ...
Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor ... Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and ... The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at ... The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some ...
... and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi ... The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the ... In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into ... AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related ...
... beta-subunit , adapter-related protein complex 3 subunit beta-2 , adaptor protein complex AP-3 subunit beta-2 , beta-3B-adaptin ... AP-3 complex beta-2 subunit , adaptor protein complex AP-3 beta-2 subunit , adaptor-related protein complex AP-3, beta 2 ... adaptor-related protein complex 3, beta 2 subunit , AP-3 complex subunit beta-2-like , AP-3 complex subunit beta-2 , Neuronal ... adaptor related protein complex 3 beta 2 subunit (ap3b2) Antikörper * adaptor-related protein complex 3, beta 2 subunit (Ap3b2 ...
"Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit". Human AP3B2 genome location and AP3B2 gene details page ... AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene. GRCh38: Ensembl release 89: ... 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917-28. doi:10.1093/emboj/16.5.917. ... DellAngelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin". ...
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
"Entrez Gene: AP3B1 adaptor-related protein complex 3, beta 1 subunit". GeneReviews/NCBI/NIH/UW entry on Hermansky-Pudlak ... AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene. This gene encodes a protein that may play ... The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin ... trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor". ...
adaptor-related protein complex 3, beta 2 subunit [Source:HGNC Symbol;Acc:567]. Human Orthologue:. AP3B2. Human Description:. ... adaptor-related protein complex 3, beta 2 subunit [Source:HGNC Symbol;Acc:567]. Mouse Orthologue:. Ap3b2. Mouse Description:. ... adaptor-related protein complex 3, beta 2 subunit Gene [Source:MGI Symbol;Acc:MGI:1100869]. ...
"Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, ... AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene. The protein encoded by this gene is one of ... "The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components". The EMBO Journal. 12 (13): 5237- ... Kim YM, Benovic JL (Aug 2002). "Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein- ...
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. Adaptor protein complex 1 is found at the ... "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; ... The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...
Adapter-related protein complex 3 subunit beta-2 antibody. *Adaptor protein complex AP-3 subunit beta-2 antibody ... Clathrin assembly protein complex 3 beta 2 large chain antibody. *Clathrin assembly protein complex 3 beta-2 large chain ... Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late- ... Neuron specific vesicle coat protein and cerebellar degeneration antigen antibody. *Neuron-specific vesicle coat protein beta- ...
... beta 1 subunit. NM_001030006. NM_001282. Gene Info. AP2M1. Adaptor-related protein complex 2, mu 1 subunit. NM_004068. NM_ ... Adaptor-related protein complex 2, alpha 1 subunit. NM_014203. NM_130787. Gene Info. ... Adaptor-related protein complex 2, alpha 2 subunit. NM_001242837. NM_012305. Gene Info. ... Adaptor-related protein complex 2, sigma 1 subunit. NM_004069. NM_021575. Gene Info. ...
The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... Adaptor related protein complex 3 beta 1 subunit. Protein classi. Protein class the gene product belongs to according to ... AP-3 complex subunit beta-1 A0A0S2Z5J4 [Target identity:100%; Query identity:100%]. Adaptor-related protein complex 3 beta 1 ... Adaptor related protein complex 3 beta 1 subunit (HGNC Symbol). Entrez gene summary. This gene encodes a protein that may play ...
adaptor-related protein complex 2, beta 1 subunit. 3710787. Incomplete. BC013699. adaptor-related protein complex 2, beta 1 ... BP] protein transport *[BP] transport *[BP] vesicle-mediated transport *[CC] clathrin adaptor complex *[CC] clathrin coat *[CC ... Protein Similarities Based on Shared Motif Content. Find gene products sharing protein motifs with: NP_082191 Protein ... Ap2b1, adaptor-related protein complex 2, beta 1 subunit. Sequence ID:. NM_001035854. NM_027915. ...
The family routinely lies on the clathrin adaptor complex 3 beta-1 subunit proteins. The exact function of DUF 1682 is unclear ... The final protein is thought to be translated from the endoplasmic reticulum into the cytoplasm of the cell. The protein is ... "Protein One". Transcription Factors. Retrieved 29 March 2014. "Protein Spotlight, The PAR b ZIP Family". Retrieved March 28, ... The portion of the protein which extends into the cytosol is predicted to be highly phosphorylated as the proteins ...
Subunit structurei. Interacts (via N-terminus) with adaptor protein complex AP-2 subunits alpha (AP2A1) and beta (AP2B1).1 ... section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes ... with other proteins or protein complexes.,p>,a href=/help/interaction_section target=_top>More...,/a>,/p>Interactioni. ,p> ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ...
3, Last annotation update) DE SubName: Full=Adaptor-related protein complex 2, beta 1 subunit; DE (MOUSE11.PE2457). GN Name= ... clathrin adaptor complex; IEA:InterPro. DR GO; GO:0005488; F:binding; IEA:InterPro. DR GO; GO:0008565; F:protein transporter ... complex_beta; 1. DR SMART; SM00809; Alpha_adaptinC2; 1. DR SUPFAM; SSF55711; AP2_adap_app; 1. DR SUPFAM; SSF48371; ARM-type_ ... DR InterPro; IPR016342; AP_complex_bsu. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; ...
Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less ... Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve ... sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent ... Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. ...
  • The absence of the β3A subunit (AP3B1) results in the loss of stability of AP3 and leads to degradation of μ3A, to which β3A is directly bound, while the other subunits are variably affected (PMID: 16507770). (ptglab.com)
  • The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules (PMID:10024875). (embl.de)
  • The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins [ PMID: 15688063 , PMID: 11961546 , PMID: 15537541 ]. (ebi.ac.uk)
  • Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels. (biomedcentral.com)
  • However, since most mature RNA is exported from the nucleus relatively quickly, most RBPs in the nucleus exist as complexes of protein and pre-mRNA called heterogeneous ribonucleoprotein particles (hnRNPs). (wikipedia.org)
  • These targets include mRNA, which codes for proteins, as well as a number of functional non-coding RNAs. (wikipedia.org)
  • This protein functions through post-transcriptional modification of mRNA transcripts by changing the nucleotide content of the RNA. (wikipedia.org)
  • MET is transcribed into a 6,641 bp mature mRNA, which is then translated into a 1,390 amino-acid MET protein. (wikipedia.org)
  • Initially, 2 mRNA species were identified, of size 4.6 and 5.8 kb, both harboring the same open reading frame encoding a putative protein of 866 amino acids (~105 kDa) protein that can be detected in most human adult tissues. (wikipedia.org)
  • Thus, for protein production, and therefore mTORC1 activation, cells must have adequate energy resources, nutrient availability, oxygen abundance, and proper growth factors in order for mRNA translation to begin. (wikipedia.org)
  • The DDB1 adaptor protein was initially characterized as the large subunit of a heterodimeric complex (UV-DDB) that was found to recognize damaged DNA and participate in a form of repair known as nucleotide excision repair (NER). (wikipedia.org)
  • The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. (merckmillipore.com)
  • Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. (merckmillipore.com)
  • As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. (merckmillipore.com)
  • This stress causes expression of the unfolded protein response pathway, which leads to a decrease in glucose tolerance and inactivation of insulin signaling in certain cell types. (wikipedia.org)
  • This acceleration of bone loss leads researchers to believe that the pathway for bone metabolism is highly regulated by several proteins that have yet to be discovered or incorporated into a schema. (wikipedia.org)
  • Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells. (wikipedia.org)
  • Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. (wikipedia.org)
  • Fyn is a protein, present in the signaling pathway of integrins, which activates ras. (wikipedia.org)
  • Mitogens, such as insulin like growth factor 1 (IGF1), can activate the MAPK/ERK pathway, which can inhibit the TSC1/TSC2 complex, activating mTORC1. (wikipedia.org)
  • Calnexin is a chaperone, characterized by assisting protein folding and quality control, ensuring that only properly folded and assembled proteins proceed further along the secretory pathway. (wikipedia.org)
  • Many of these proteins serve as adaptors that link p97/CDC48 to a particular subcellular compartment to function in a specific cellular pathway. (wikipedia.org)
  • In the open state, both [D/E]XXXL[L/I] and YXXØ-binding sites are exposed and ready to bind to corresponding cargo proteins (yellowish circles). (bioscirep.org)
  • These repeats can stack together to form a curved shaped structure, which facilitates binding to the NLS of specific cargo proteins. (wikipedia.org)
  • The protein encoded by CCDC47 is 483 amino acids in length and contains both a signal peptide and transmembrane domain. (wikipedia.org)
  • KKGEIFELKAELNSDKKEK , corresponding to N terminal amino acids 10-29 of AP1 and 2 (beta). (abcam.com)
  • The accumulation of proteins in the nucleus is mediated by short sequences of basic amino acids called nuclear localization sequences (NLSs). (abcam.com)
  • This domain is rich in hydrophobic amino acids, the mutation of which impairs the ability of LC3 binding with LIR containing proteins, many of which are autophagy cargo adapter proteins. (wikipedia.org)
  • Its length is approximately 100 amino acids long and it is found within 111 human proteins. (wikipedia.org)
  • fsTnI is a 21.3 kDa protein consisting of 182 amino acids including the first methionine with an isoelectric point (pI) of 8.74. (wikipedia.org)
  • Symptoms are caused by the insertion of a small segment of DNA (known as the T-DNA, for 'transfer DNA', not to be confused with tRNA that transfers amino acids during protein synthesis, confusingly also called transfer RNA), from a plasmid, into the plant cell, which is incorporated at a semi-random location into the plant genome. (wikipedia.org)
  • The activity of this complex is regulated by rapamycin, insulin, growth factors, phosphatidic acid, certain amino acids and their derivatives (e.g. (wikipedia.org)
  • Dynein and dynactin do not run together in a sucrose gradient, but can be induced to form a tight complex in the presence of the N-terminal 400 amino acids of Bicaudal D2 (BICD2), a cargo adaptor that links dynein and dynactin to Golgi derived vesicles. (wikipedia.org)
  • Conserved binding sites in mammals which are located on this promoter include Nuclear Respiratory Factor 1 (NFR1), cAMP-responsive element binding protein (CREB), PAR b ZIP family and Sp4 Transcription Factor. (wikipedia.org)
  • This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. (genecards.org)
  • These sequences are necessary and sufficient to direct a protein or inert carrier to the nuclear interior. (abcam.com)
  • Nuclear protein import is accomplished by two sequential, energy dependent events. (abcam.com)
  • The second step, translocation across the nuclear envelope (NE), requires the GTP-binding protein, Ran/TC4. (abcam.com)
  • There is evidence indicating that parts of the nuclear pore complex and COPII may be evolutionarily related. (wikipedia.org)
  • In resting cells, IκBα is found in complex with NF-κB transcription factor subunits p65 and p50, preventing their nuclear translocation and activation of NF-κB-dependent gene transcription. (asm.org)
  • The importance of the nuclear functions of autophagy proteins should not be underestimated. (wikipedia.org)
  • LC3 is also enriched in nucleoli via its triple arginine motif, and associates with a number of different nuclear and nucleolar constituents including: MAP1B, tubulin, and several ribosomal proteins. (wikipedia.org)
  • The process of nuclear protein import had already been characterised in previous reviews, but the key proteins involved had not been elucidated up until that point. (wikipedia.org)
  • In order to transport cargo into the nucleus, importin-β must associate with the nuclear pore complexes. (wikipedia.org)
  • PAK proteins are critical effectors that link the Rho family of GTPases (Rho GTPases) to cytoskeleton reorganization and nuclear signaling. (wikipedia.org)
  • The function of the essential Esa1 protein as the HAT subunit of NuA4 and the presence of Tra1p, a putative [[transcription]] activator-interacting subunit, supports an essential link between nuclear H4 acetylation, transcriptional regulation and cell cycle control. (wikipedia.org)
  • Once miR-155 pri-miRNA is transcribed, this transcript is cleaved by the nuclear microprocessor complex, of which the core components are the RNase III type endonuclease Drosha and the DiGeorge critical region 8 (DGCR8) protein, to produce a 65 nucleotide stem-loop precursor miRNA (pre-mir-155) (see Figure 2). (wikipedia.org)
  • PEC subunits p62/DCTN4 and Arp11/Actr10 are essential for dynactin complex integrity and dynactin/dynein targeting to the nuclear envelope before mitosis. (wikipedia.org)
  • Dynactin contributes to mitotic spindle pole focusing through its binding to nuclear mitotic apparatus protein (NuMA). (wikipedia.org)
  • NatA may also regulate co-translational protein folding and protein targeting to the endoplasmic reticulum, possibly through competition with SRP and NAC for the same ribosomal binding sites or through yet unknown interference with other ribosome-associated protein biogenesis factors, such as the MetAPs, the chaperones Hsp70/Hsp40, SRP and NAC, which act on newly synthesized proteins as soon as they emerge from the ribosome exit tunnel. (wikipedia.org)
  • Ribosomal RNAs catalyse the translation of nucleotide sequences to protein. (wikipedia.org)