Adaptor Protein Complex beta Subunits: A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.Adaptor Protein Complex 3: An adaptor protein complex found primarily on perinuclear compartments.Adaptor Protein Complex 1: A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.Adaptor Protein Complex 2: An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.Adaptor Protein Complex 4: An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.Adaptor Protein Complex Subunits: The subunits that make up the large, medium and small chains of adaptor proteins.Adaptor Protein Complex delta Subunits: A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.Adaptor Protein Complex mu Subunits: A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.Adaptor Proteins, Vesicular Transport: A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.Adaptor Protein Complex gamma Subunits: A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.Adaptor Protein Complex alpha Subunits: A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesClathrin: The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.Human Characteristics: The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)Monomeric Clathrin Assembly Proteins: A subclass of clathrin assembly proteins that occur as monomers.Protein Subunits: Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
(1/89) The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.

betaarrestins mediate the desensitization of the beta2-adrenergic receptor (beta2AR) and many other G protein-coupled receptors (GPCRs). Additionally, betaarrestins initiate the endocytosis of these receptors via clathrin coated-pits and interact directly with clathrin. Consequently, it has been proposed that betaarrestins serve as clathrin adaptors for the GPCR family by linking these receptors to clathrin lattices. AP-2, the heterotetrameric clathrin adaptor protein, has been demonstrated to mediate the internalization of many types of plasma membrane proteins other than GPCRs. AP-2 interacts with the clathrin heavy chain and cytoplasmic domains of receptors such as those for epidermal growth factor and transferrin. In the present study we demonstrate the formation of an agonist-induced multimeric complex containing a GPCR, betaarrestin 2, and the beta2-adaptin subunit of AP-2. beta2-Adaptin binds betaarrestin 2 in a yeast two-hybrid assay and coimmunoprecipitates with betaarrestins and beta2AR in an agonist-dependent manner in HEK-293 cells. Moreover, beta2-adaptin translocates from the cytosol to the plasma membrane in response to the beta2AR agonist isoproterenol and colocalizes with beta2AR in clathrin-coated pits. Finally, expression of betaarrestin 2 minigene constructs containing the beta2-adaptin interacting region inhibits beta2AR endocytosis. These findings point to a role for AP-2 in GPCR endocytosis, and they suggest that AP-2 functions as a clathrin adaptor for the endocytosis of diverse classes of membrane receptors.  (+info)

(2/89) Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts.

Analysis of 600 kb of sequence encompassing the beta-prime adaptin (BAM22) gene on human chromosome 22 revealed intrachromosomal duplications within 22q12-13 resulting in three active RFPL genes, two RFPL pseudogenes, and two pseudogenes of BAM22. The genomic sequence of BAM22vartheta1 shows a remarkable similarity to that of BAM22. The cDNA sequence comparison of RFPL1, RFPL2, and RFPL3 showed 95%-96% identity between the genes, which were most similar to the Ret Finger Protein gene from human chromosome 6. The sense RFPL transcripts encode proteins with the tripartite structure, composed of RING finger, coiled-coil, and B30-2 domains, which are characteristic of the RING-B30 family. Each of these domains are thought to mediate protein-protein interactions by promoting homo- or heterodimerization. The MID1 gene on Xp22 is also a member of the RING-B30 family and is mutated in Opitz syndrome (OS). The autosomal dominant form of OS shows linkage to 22q11-q12. We detected a polymorphic protein-truncating allele of RFPL1 in 8% of the population, which was not associated with the OS phenotype. We identified 6-kb and 1.2-kb noncoding antisense mRNAs of RFPL1S and RFPL3S antisense genes, respectively. The RFPL1S and RFPL3S genes cover substantial portions of their sense counterparts, which suggests that the function of RFPL1S and RFPL3S is a post-transcriptional regulation of the sense RFPL genes. We illustrate the role of intrachromosomal duplications in the generation of RFPL genes, which were created by a series of duplications and share an ancestor with the RING-B30 domain containing genes from the major histocompatibility complex region on human chromosome 6.  (+info)

(3/89) The structure and function of the beta 2-adaptin appendage domain.

The heterotetrameric AP2 adaptor (alpha, beta 2, mu 2 and sigma 2 subunits) plays a central role in clathrin-mediated endocytosis. We present the protein recruitment function and 1.7 A resolution structure of its beta 2-appendage domain to complement those previously determined for the mu 2 subunit and alpha appendage. Using structure-directed mutagenesis, we demonstrate the ability of the beta 2 appendage alone to bind directly to clathrin and the accessory proteins AP180, epsin and eps15 at the same site. Clathrin polymerization is promoted by binding of clathrin simultaneously to the beta 2-appendage site and to a second site on the adjacent beta 2 hinge. This results in the displacement of the other ligands from the beta 2 appendage. Thus clathrin binding to an AP2-accessory protein complex would cause the controlled release of accessory proteins at sites of vesicle formation.  (+info)

(4/89) beta2-adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase.

Clathrin-mediated endocytosis includes cycles of assembly and disassembly of the clathrin-coated vesicle constituents. How these cycles are regulated is still not fully known but previous studies have indicated that phosphorylation of coat subunits may play a role. Here we describe that beta2-adaptin undergoes cycles of phosphorylation/de-phosphorylation in intact cells. Thus, beta2-adaptin was constitutively de-phosphorylated by serine/threonine protein phosphatase 2A and phosphorylated by a staurosporine-sensitive kinase in vivo. Confocal laser scanning microscopy demonstrated that phosphorylated AP2 complexes were found more evenly distributed at the plasma membrane compared to non-phosphorylated AP2 complexes which were found in aggregates. Finally, we found that phosphorylation of beta2-adaptin correlated with inhibition of clathrin-mediated endocytosis. Our results support the hypothesis that phosphorylation/de-phosphorylation of coat proteins plays a regulatory role in the assembly/disassembly cycle of clathrin-coated vesicles.  (+info)

(5/89) Defective organellar membrane protein trafficking in Ap3b1-deficient cells.

AP-3 is a heterotetrameric protein complex involved in intracellular vesicle transport. Molecular analyses show that Ap3b1, which encodes the AP-3 (&bgr;)3A subunit, is altered in pearl mice. To provide genetic evidence that mutation of Ap3b1 is responsible for the pearl phenotype and to determine the null phenotype, the Ap3b1 gene was disrupted by homologous recombination. Mice homozygous for the resulting allele, Ap3b1(LN), or compound heterozygotes with pearl, displayed phenotypes similar to those of pearl mice, confirming that Ap3b1 is the causal gene for pearl. Moreover, pearl is likely to be a hypomorph as the Ap3b1(LN) homozygotes had a lighter coat color and accumulated fewer of the micro3 and (&dgr;)3 subunits of AP-3 than did pearl mice. Finally, immunofluorescence analysis of fibroblasts and melanocytes cultured from Ap3b1(LN) homozygotes revealed that the lysosomal membrane proteins Lamp I and Lamp II and the melanosomal membrane protein tyrosinase were mislocalized. In particular, the Lamp proteins were clustered on the cell surface. These findings strengthen the evidence for an alternate pathway via the plasma membrane for cargo normally transported to organelles by AP-3.  (+info)

(6/89) A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex.

Intracellular transport mediated by kinesin superfamily proteins (KIFs) is a highly regulated process. The molecular mechanism of KIFs binding to their respective cargoes remains unclear. We report that KIF13A is a novel plus end-directed microtubule-dependent motor protein and associates with beta 1-adaptin, a subunit of the AP-1 adaptor complex. The cargo vesicles of KIF13A contained AP-1 and mannnose-6-phosphate receptor (M6PR). Overexpression of KIF13A resulted in mislocalization of the AP-1 and the M6PR. Functional blockade of KIF13A reduced cell surface expression of the M6PR. Thus, KIF13A transports M6PR-containing vesicles and targets the M6PR from TGN to the plasma membrane via direct interaction with the AP-1 adaptor complex.  (+info)

(7/89) Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles.

A native immunoisolation procedure has been used to investigate the role of clathrin-coated vesicles (CCVs) in the transport of vacuolar proteins between the trans-Golgi network (TGN) and the prevacuolar/endosome compartments in the yeast Saccharomyces cerevisiae. We find that Apl2p, one large subunit of the adaptor protein-1 complex, and Vps10p, the carboxypeptidase Y vacuolar protein receptor, are associated with clathrin molecules. Vps10p packaging in CCVs is reduced in pep12 Delta and vps34 Delta, two mutants that block Vps10p transport from the TGN to the endosome. However, Vps10p sorting is independent of Apl2p. Interestingly, a Vps10C(t) Delta p mutant lacking its C-terminal cytoplasmic domain, the portion of the receptor responsible for carboxypeptidase Y sorting, is also coimmunoprecipitated with clathrin. Our results suggest that CCVs mediate Vps10p transport from the TGN to the endosome independent of direct interactions between Vps10p and clathrin coats. The Vps10p C-terminal domain appears to play a principal role in retrieval of Vps10p from the prevacuolar compartment rather than in sorting from the TGN.  (+info)

(8/89) Hermansky-Pudlak syndrome type 3 in Ashkenazi Jews and other non-Puerto Rican patients with hypopigmentation and platelet storage-pool deficiency.

Hermansky-Pudlak syndrome (HPS), consisting of oculocutaneous albinism and a bleeding diathesis due to the absence of platelet dense granules, displays extensive locus heterogeneity. HPS1 mutations cause HPS-1 disease, and ADTB3A mutations cause HPS-2 disease, which is known to involve abnormal intracellular vesicle formation. A third HPS-causing gene, HPS3, was recently identified on the basis of homozygosity mapping of a genetic isolate of HPS in central Puerto Rico. We now describe the clinical and molecular characteristics of eight patients with HPS-3 who are of non-Puerto Rican heritage. Five are Ashkenazi Jews; three of these are homozygous for a 1303+1G-->A splice-site mutation that causes skipping of exon 5, deleting an RsaI restriction site and decreasing the amounts of mRNA found on northern blotting. The other two are heterozygous for the 1303+1G-->A mutation and for either an 1831+2T-->G or a 2621-2A-->G splicing mutation. Of 235 anonymous Ashkenazi Jewish DNA samples, one was heterozygous for the 1303+1G-->A mutation. One seven-year-old boy of German/Swiss extraction was compound heterozygous for a 2729+1G-->C mutation, causing skipping of exon 14, and resulting in a C1329T missense (R396W), with decreased mRNA production. A 15-year-old Irish/English boy was heterozygous for an 89-bp insertion between exons 16 and 17 resulting from abnormal splicing; his fibroblast HPS3 mRNA is normal in amount but is increased in size. A 12-year-old girl of Puerto Rican and Italian background has the 3,904-bp founder deletion from central Puerto Rico on one allele. All eight patients have mild symptoms of HPS; two Jewish patients had received the diagnosis of ocular, rather than oculocutaneous, albinism. These findings expand the molecular diagnosis of HPS, provide a screening method for a mutation common among Jews, and suggest that other patients with mild hypopigmentation and decreased vision should be examined for HPS.  (+info)

*  AP3B2
"Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit". Human AP3B2 genome location and AP3B2 gene details page ... AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene. GRCh38: Ensembl release 89: ... 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917-28. doi:10.1093/emboj/16.5.917. ... Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin". ...
*  AP2B1
"Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, ... AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene. The protein encoded by this gene is one of ... "The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components". The EMBO Journal. 12 (13): 5237- ... Kim YM, Benovic JL (Aug 2002). "Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein- ...
*  AP1B1
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. Adaptor protein complex 1 is found at the ... "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit". Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; ... The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ...
*  AP4B1
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. The heterotetrameric adaptor protein (AP ... "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". Hirst J, Bright NA, Rous B, Robinson MS (August 1999). " ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
*  AP3B1
"Entrez Gene: AP3B1 adaptor-related protein complex 3, beta 1 subunit". GeneReviews/NCBI/NIH/UW entry on Hermansky-Pudlak ... AP-3 complex subunit beta-1 is a protein that in humans is encoded by the AP3B1 gene. This gene encodes a protein that may play ... The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin ... trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor". ...
*  Sec61 alpha 1
... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... contains beta and gamma subunits. GRCh38: Ensembl release 89: ENSG00000058262 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
*  CCDC47
The family routinely lies on the clathrin adaptor complex 3 beta-1 subunit proteins. The exact function of DUF 1682 is unclear ... The final protein is thought to be translated from the endoplasmic reticulum into the cytoplasm of the cell. The protein is ... "Protein One". Transcription Factors. Retrieved 29 March 2014. "Protein Spotlight, The PAR b ZIP Family". Retrieved March 28, ... The portion of the protein which extends into the cytosol is predicted to be highly phosphorylated as the protein's ...
*  Adaptor-related protein complex 2, alpha 1
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ...
*  Adaptor complexes medium subunit domain
In molecular biology, the adaptor complexes medium subunit domain is a protein domain found at the C-terminus of the mu subunit ... The C-terminal domain has an immunoglobulin-like beta-sandwich fold consisting of 9 strands in 2 sheets with a Greek key ... "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". The ...
*  List of adaptins
Adaptins are clustered subunits of adaptor protein (AP) complexes.. There are several types of adaptin, each related to a ... beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma): complex 1 AP1B1 AP1G1 AP1G2 ... 2011) The Fifth Adaptor Protein Complex. PLoS Biol 9(10): e1001170. doi:10.1371/journal.pbio.1001170. ... "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". ncbi. ...
*  AP2M1
"Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit". Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, ... "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, ... AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene. This gene encodes a subunit of the ... heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The ...
*  Focal adhesion
... and some of the adapter proteins, such as talin, paxillin and tensin. Many of these focal complexes fail to mature and are ... Integrins are heterodimers which are formed from one beta and one alpha subunit. These subunits are present in different forms ... bind to and associate with this integrin-adapter protein-cytoskeleton complex, and this forms the basis of a focal adhesion. ... However, some focal complexes mature into larger and stable focal adhesions, and recruit many more proteins such as zyxin. ...
*  Clathrin adaptor protein
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... beta-1-adaptin, mu-1 and sigma-1, while in AP2 they are alpha-adaptin, beta-2-adaptin, mu-2 and sigma-2. Each subunit has a ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
*  Vesicular transport adaptor protein
... and two smaller proteins. One of the large proteins is termed β (beta), with β1 in the AP-1 complex, β2 in the AP-2 complex, ... The two smaller proteins are a medium subunit named μ (mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ...
*  AP3M1
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the ... trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor". ... "Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit". Human AP3M1 genome location and AP3M1 gene details page in ... 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based ...
*  MED15
... multiprotein complex) glutamine/Q-rich-associated protein". Suzuki Y, Nogi Y, Abe A, Fukasawa T (Nov 1988). "GAL11 protein, an ... Kato Y, Habas R, Katsuyama Y, Näär AM, He X (Aug 2002). "A component of the ARC/Mediator complex required for TGF beta/Nodal ... Abraham S, Solomon WB (Sep 2000). "A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially ... "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular ...
*  AP4S1
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. The heterotetrameric adaptor protein (AP ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ... Dell'Angelica EC, Mullins C, Bonifacino JS (1999). "AP-4, a novel protein complex related to clathrin adaptors". J. Biol. Chem ...
*  AP4E1
AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ... AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (AP4M1), and a small ... 2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using ... Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell ...
*  ATP6V1H
"Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery". ... Geyer M, Fackler OT, Peterlin BM (Jun 2002). "Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins ... The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain ... The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit ...
*  B2-adapt-app C
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... a medium subunit (mu) and a small subunit (sigma). For example, in AP1 these subunits are gamma-1-adaptin, beta-1-adaptin, mu-1 ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
*  AP1M1
"Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA ... The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located ... AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene. The protein encoded by this gene is the ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...
*  Chromosome 20 (human)
... encoding protein Beta-soluble NSF attachment protein NOL5A: encoding protein Nucleolar protein 56 NRSN2: encoding protein ... encoding protein Kizuna centrosomal protein Kua-UEV: LIME1: encoding protein Lck-interacting transmembrane adapter 1 LZTS3: ... encoding protein Zinc finger protein PLAGL2 POLR3F: encoding enzyme DNA-directed RNA polymerase III subunit RPC6 PRIC285: PRNP ... encoding enzyme Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog VAPB: VAMP (vesicle-associated membrane protein ...
*  AP1G2
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ...
*  AP1G1
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ...
*  APC/C activator protein CDH1
Li M, Shin YH, Hou L, Huang X, Wei Z, Klann E, Zhang P (2008). "The adaptor protein of the anaphase promoting complex Cdh1 is ... WD repeat proteins are assumed to form a circularized beta propeller structure, which is thought to be essential for the ... which is suggested to bind to the Cdc27 subunit of APC. Cdh1 has 7 WD repeats, which are located between the middle of the ... Cdh1 is one of the substrate adaptor protein of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces ...
*  ABL (gene)
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J ... a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes". J. ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ...
anti-beta-Adaptin antibody [N3C1], Internal  | GeneTex  anti-beta-Adaptin antibody [N3C1], Internal | GeneTex
... adaptor-related protein complex 1, beta 1 subunit) for WB. Anti-beta-Adaptin pAb (GTX101753) is tested in Human, Mouse samples ... Golgi adaptor HA1/AP1 adaptin beta subunit antibody, AP-1 complex subunit beta-1 antibody, adaptor protein complex AP-1 subunit ... adaptor-related protein complex 1, beta 1 subunit. Background. Adaptor protein complex 1 is found at the cytoplasmic face of ... clathrin assembly protein complex 1 beta large chain antibody, beta1-adaptin antibody, "adaptor-related protein complex 1, beta ...
more infohttp://www.genetex.com/beta-Adaptin-antibody-N3C1-Internal-GTX101753.html
AP2B1 adaptor related protein complex 2 subunit beta 1 [Homo sapiens (human)] - Gene - NCBI  AP2B1 adaptor related protein complex 2 subunit beta 1 [Homo sapiens (human)] - Gene - NCBI
adaptin, beta 2 (beta). adaptor protein complex AP-2 subunit beta. adaptor related protein complex 2 beta 1 subunit. adaptor- ... AP-2 complex subunit beta. Names. adapter-related protein complex 2 beta subunit. adapter-related protein complex 2 subunit ... AP2B1 adaptor related protein complex 2 subunit beta 1 [Homo sapiens] AP2B1 adaptor related protein complex 2 subunit beta 1 [ ... related protein complex 2 subunit beta. beta-2-adaptin. beta-adaptin. clathrin assembly protein complex 2 beta large chain. ...
more infohttps://www.ncbi.nlm.nih.gov/gene/163
AP2B1 (adaptor-related protein complex 2, beta 1 subunit) - KOMP (Knockout Mouse Project)  AP2B1 (adaptor-related protein complex 2, beta 1 subunit) - KOMP (Knockout Mouse Project)
... "adaptor-related protein complex 2, beta 1 subunit")*CCDS: 25161, 25161.1, 25162, 25162.1*OMIM: ADAPTOR-RELATED PROTEIN COMPLEX ... adaptor-related protein complex 2, beta 1 subunit. Synonyms: 1300012O03Rik. Gene nomenclature, locus information, and GO, OMIM ... BETA-1 SUBUNIT; AP2B1*Gene Ontology: Ap2b1 *Mouse Phenome DB: Ap2b1 *UCSC: Chr.11:83,302,697-83,405,035(+)*IMPC: Ap2b1 ...
more infohttps://www.komp.org/geneinfo.php?geneid=23441
Adapter-related protein complex 3 subunit beta-1 | definition of Adapter-related protein complex 3 subunit beta-1 by Medical...  Adapter-related protein complex 3 subunit beta-1 | definition of Adapter-related protein complex 3 subunit beta-1 by Medical...
What is Adapter-related protein complex 3 subunit beta-1? Meaning of Adapter-related protein complex 3 subunit beta-1 medical ... What does Adapter-related protein complex 3 subunit beta-1 mean? ... Looking for online definition of Adapter-related protein ... complex 3 subunit beta-1 in the Medical Dictionary? Adapter-related protein complex 3 subunit beta-1 explanation free. ... Adapter-related protein complex 3 subunit beta-1 , definition of Adapter-related protein complex 3 subunit beta-1 by Medical ...
more infohttps://medical-dictionary.thefreedictionary.com/Adapter-related+protein+complex+3+subunit+beta-1
AP4B1 gene - Genetics Home Reference - NIH  AP4B1 gene - Genetics Home Reference - NIH
adaptor related protein complex 4 subunit beta 1. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in ... This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans- ... It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization ...
more infohttps://ghr.nlm.nih.gov/gene/AP4B1
AP2B1 Gene - GeneCards | AP2B1 Protein | AP2B1 Antibody  AP2B1 Gene - GeneCards | AP2B1 Protein | AP2B1 Antibody
Protein Coding), Adaptor Related Protein Complex 2 Beta 1 Subunit, including: function, proteins, disorders, pathways, ... Plasma membrane adaptor HA2/AP2 adaptin beta subunit (AP2B1_HUMAN). *Adaptor-related protein complex 2, beta 1 subunit, isoform ... beta 1 subunit, isoform CRA_b (E1P647_HUMAN). *Adaptor-related protein complex 2, beta 1 subunit, isoform CRA_c (E1P648_HUMAN) ... Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=163
Produktübersicht anti-AP3B2 Antikörper  Produktübersicht anti-AP3B2 Antikörper
... beta-subunit , adapter-related protein complex 3 subunit beta-2 , adaptor protein complex AP-3 subunit beta-2 , beta-3B-adaptin ... AP-3 complex beta-2 subunit , adaptor protein complex AP-3 beta-2 subunit , adaptor-related protein complex AP-3, beta 2 ... adaptor-related protein complex 3, beta 2 subunit , AP-3 complex subunit beta-2-like , AP-3 complex subunit beta-2 , Neuronal ... adaptor related protein complex 3 beta 2 subunit (ap3b2) Antikörper * adaptor-related protein complex 3, beta 2 subunit (Ap3b2 ...
more infohttps://www.antikoerper-online.de/abstract/Adaptor-Related+Protein+Complex+3%2C+beta+2+Subunit+
Ap3b2 - AP-3 complex subunit beta-2 - Mus musculus (Mouse) - Ap3b2 gene & protein  Ap3b2 - AP-3 complex subunit beta-2 - Mus musculus (Mouse) - Ap3b2 gene & protein
... and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi ... The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the ... In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into ... AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related ...
more infohttp://www.uniprot.org/uniprot/Q9JME5
AP3B1 - AP-3 complex subunit beta-1 - Canis lupus familiaris (Dog) - AP3B1 gene & protein  AP3B1 - AP-3 complex subunit beta-1 - Canis lupus familiaris (Dog) - AP3B1 gene & protein
... and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi ... The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the ... In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into ... AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related ...
more infohttp://www.uniprot.org/uniprot/Q7YRF1
GO Gene List  GO Gene List
... beta 1 subunit. NM_001030006. NM_001282. Gene Info. AP2M1. Adaptor-related protein complex 2, mu 1 subunit. NM_004068. NM_ ... Adaptor-related protein complex 2, alpha 1 subunit. NM_014203. NM_130787. Gene Info. ... Adaptor-related protein complex 2, alpha 2 subunit. NM_001242837. NM_012305. Gene Info. ... Adaptor-related protein complex 2, sigma 1 subunit. NM_004069. NM_021575. Gene Info. ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0009966
Expression of AP3B1 in cancer - Summary - The Human Protein Atlas  Expression of AP3B1 in cancer - Summary - The Human Protein Atlas
The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... Adaptor related protein complex 3 beta 1 subunit. Protein classi. Protein class the gene product belongs to according to ... AP-3 complex subunit beta-1 A0A0S2Z5J4 [Target identity:100%; Query identity:100%]. Adaptor-related protein complex 3 beta 1 ... Adaptor related protein complex 3 beta 1 subunit (HGNC Symbol). Entrez gene summary. This gene encodes a protein that may play ...
more infohttps://www.proteinatlas.org/ENSG00000132842-AP3B1/pathology
Gene Info  Gene Info
adaptor-related protein complex 2, beta 1 subunit. 3710787. Incomplete. BC013699. adaptor-related protein complex 2, beta 1 ... BP] protein transport *[BP] transport *[BP] vesicle-mediated transport *[CC] clathrin adaptor complex *[CC] clathrin coat *[CC ... Protein Similarities Based on Shared Motif Content. Find gene products sharing protein motifs with: NP_082191 Protein ... Ap2b1, adaptor-related protein complex 2, beta 1 subunit. Sequence ID:. NM_001035854. NM_027915. ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Mm&CID=39053&LLNO=71770
Gene Browser  Gene Browser
ADAPTOR-RELATED PROTEIN COMPLEX 3, BETA-1 SUBUNIT; AP3B1. Chromosome 5. 603401. 608233. ... ANTHRACYCLINE RESISTANCE-ASSOCIATED PROTEIN; ARA. 16p13.1. 603234. 264800. ABCD1. ATP-BINDING CASSETTE, SUBFAMILY D, MEMBER 1; ... ATPase Cu(2+)-TRANSPORTING BETA POLYPEPTIDE; ATP7B. 13q14.3. 606882. 277900. ATR. ATAXIA-TELANGIECTASIA AND RAD3-RELATED; ATR. ...
more infohttps://www.coriell.org/0/Sections/BrowseCatalog/Genes.aspx?PgId=5
AP4B1 - ddPCR Primer Pair - EvaGreen - Digital PCR | PrimePCR | Bio-Rad  AP4B1 - ddPCR Primer Pair - EvaGreen - Digital PCR | PrimePCR | Bio-Rad
adaptor-related protein complex 4, beta 1 subunit Aliases:. BETA-4 RefSeq:. NC_000001.10 NT_032977.9 ... This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans- ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/dhsaeg5005763-primepcr-ddpcr-expression-evagreen-assay-ap4b1-human
Ap3b2 - PrimePCR Assay and Template | Life Science | Bio-Rad  Ap3b2 - PrimePCR Assay and Template | Life Science | Bio-Rad
Adaptor-related protein complex 3, beta 2 subunit Assay Type: Probe Assay Design: Intron-spanning Application: Gene Expression ... Adaptor-related protein complex 3, beta 2 subunit Assay Type: SYBR® Green Assay Design: Intron-spanning Application: Gene ... Adaptor-related protein complex 3, beta 2 subunit Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: ... Adaptor-related protein complex 3, beta 2 subunit Assay Type: Probe Application: Gene Expression Unique Assay ID: ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/gene/ap3b2-mouse
Spastic Paraplegia Disorders 88 Gene Panel - UK Genetic Testing Network  Spastic Paraplegia Disorders 88 Gene Panel - UK Genetic Testing Network
adaptor related protein complex 4, beta 1 subunit *BETA-4. * AP4B1 *SPG47 ... adaptor-related protein complex 1, sigma 2 subunit *mental retardation, X-linked 59 ... RAB3 GTPase activating non-catalytic protein subunit 2 *RAB3 GTPase activating protein subunit 2 (non-catalytic) ... beta-1,4-N-acetyl-galactosaminyl transferase 1 *spastic paraplegia 26. *UDP-Gal:betaGlcNAc beta-1,4-N- ...
more infohttps://ukgtn.nhs.uk/find-a-test/search-by-disorder-gene/spastic-paraplegia-disorders-88-gene-panel-889/
AP3B2 - Wikipedia  AP3B2 - Wikipedia
"Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit". Human AP3B2 genome location and AP3B2 gene details page ... AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene. GRCh38: Ensembl release 89: ... 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917-28. doi:10.1093/emboj/16.5.917. ... Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin". ...
more infohttps://en.wikipedia.org/wiki/AP3B2
AP2B1 - Wikipedia  AP2B1 - Wikipedia
"Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, ... AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene. The protein encoded by this gene is one of ... "The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components". The EMBO Journal. 12 (13): 5237- ... Kim YM, Benovic JL (Aug 2002). "Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein- ...
more infohttps://en.wikipedia.org/wiki/AP2B1
HOGENOM: MOUSE11 PE2457  HOGENOM: MOUSE11 PE2457
3, Last annotation update) DE SubName: Full=Adaptor-related protein complex 2, beta 1 subunit; DE (MOUSE11.PE2457). GN Name= ... clathrin adaptor complex; IEA:InterPro. DR GO; GO:0005488; F:binding; IEA:InterPro. DR GO; GO:0008565; F:protein transporter ... complex_beta; 1. DR SMART; SM00809; Alpha_adaptinC2; 1. DR SUPFAM; SSF55711; AP2_adap_app; 1. DR SUPFAM; SSF48371; ARM-type_ ... DR InterPro; IPR016342; AP_complex_bsu. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; ...
more infohttp://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-id?query=MOUSE11_PE2457&db=HOGENOM&ident=ACNUC22857
SMART: B2-adapt-app C domain annotation  SMART: B2-adapt-app C domain annotation
Solution NMR structure of beta-adaptin appendage domain of human adaptor protein complex 4 subunit beta, Northeast Structural ... intracellular protein transport (GO:0006886), vesicle-mediated transport (GO:0016192). GO component:. clathrin adaptor complex ... Click on the protein counts, or double click on taxonomic names to display all proteins containing B2-adapt-app_C domain in the ... This domain has a three-layer arrangement, alpha-beta-alpha, with a bifurcated antiparallel beta-sheet [(PUBMED:10430869)]. ...
more infohttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=B2-adapt-app_C&BLAST=DUMMY
  • Entrez Gene: ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H". Human ATP6V1H genome location and ATP6V1H gene details page in the UCSC Genome Browser. (wikipedia.org)
  • The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules (PMID:10024875). (embl.de)
  • Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model. (ptglab.com)
  • AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. (wikipedia.org)
  • The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
  • Biochemical and X-ray crystallographic analyses reveal that the properties of the APP sequence and the location of the binding site on mu4 are distinct from those of other signal-adaptor interactions. (rcsb.org)
  • Human CUL4B forms direct interactions with: RBX1 CAND1 DDB1 and the COP9 signalosome Human CUL4B-DDB1-RBX1 complexes promote the ubiquitination of: Cdt1 p21 PR-Set7/SET8 p12 subunit of DNA polymerase δ SAMHD1† UNG2† IKZF1§ IKZF3§ †protein is a CRL4 substrate only when directed by viral proteins §protein is a CRL4 substrate only when directed by IMiDs Published version Jeffrey Hannah, Pengbo Zhou (15 November 2015). (wikipedia.org)
  • They are sometimes considered to occupy an intermediate position between globular proteins and fibrous structural proteins, distinct from the latter in part due to the alpha solenoids' lack of need for intermolecular interactions to maintain their structure. (wikipedia.org)
  • Due to their propensity for forming large interaction surfaces well-suited to protein-protein interactions, and their flexible surfaces permitting binding of various cargo molecules, alpha solenoid proteins commonly function as transport proteins, particularly in transport between the nucleus and the cytoplasm. (wikipedia.org)
  • Herein, we report the interaction of an YKFFE sequence from the cytosolic tail of the Alzheimer's disease amyloid precursor protein (APP) with the mu4 subunit of AP-4. (rcsb.org)
  • Disruption of the APP-AP-4 interaction decreases localization of APP to endosomes and enhances gamma-secretase-catalyzed cleavage of APP to the pathogenic amyloid-beta peptide. (rcsb.org)
  • and a less well-conserved C-terminal domain of around 190 amino acids, which may be the site of specific interaction with the protein being transported in the vesicle. (wikipedia.org)
  • This interaction is crucial for the recruitment of substrates to the ubiquitin ligase complex. (wikipedia.org)
  • The extent of the curvature of an alpha solenoid superhelix varies considerably among the class, resulting in the ability of these proteins to form large, extended protein-protein interaction surfaces or to form deep concave areas for binding globular proteins. (wikipedia.org)
  • Because they are composed of repeating relatively short subunits, alpha solenoids can acquire additional subunits relatively easily, resulting in new interaction surface properties. (wikipedia.org)
  • The protein-protein interaction capacity of alpha solenoid proteins also makes them well suited to function as regulatory proteins. (wikipedia.org)
  • RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating enzymes. (wikipedia.org)
  • This modification appears to induce conformational changes which promotes flexibility in the RING domain of cullin proteins and enhanced ubiquitin ligase activity. (wikipedia.org)
  • CUL4B-based E3 ubiquitin ligase complexes often demonstrate overlapping activity with CUL4A-based complexes. (wikipedia.org)
  • CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. (wikipedia.org)
  • As a result, the N-terminus is crucial for the recruitment of substrates for the ubiquitin ligase complex. (wikipedia.org)
  • Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. (nih.gov)
  • For example, regulatory subunit A (also known as PR65) of protein phosphatase 2A is a HEAT-repeat alpha solenoid whose conformational flexibility regulates access to the enzyme binding site. (wikipedia.org)
  • KKGEIFELKAELNSDKKEK , corresponding to N terminal amino acids 10-29 of AP1 and 2 (beta). (abcam.com)
  • The protein encoded by CCDC47 is 483 amino acids in length and contains both a signal peptide and transmembrane domain. (wikipedia.org)
  • The protein is anchored in the membrane of the ER at the transmembrane domain located from amino acid 137 to 165. (wikipedia.org)
  • Integrins bind to extra-cellular proteins via short amino acid sequences, such as the RGD motif (found in proteins such as fibronectin, laminin, or vitronectin), or the DGEA and GFOGER motifs found in collagen. (wikipedia.org)
  • The protein sequence of cdh1 consists of 566 amino acids and has a molecular weight of 62.8 kDa. (wikipedia.org)
  • In the N-terminal region at amino acid position 55-61 the cdh1 protein contains a C-Box motif, which is required for the association with the APC/c complex. (wikipedia.org)
  • CUL4A protein is 759 amino acids long and forms an extended, rigid structure primarily consisting of alpha-helices. (wikipedia.org)
  • A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. (nih.gov)
  • Results suggest that autosomal recessive hypercholesterolemia (ARH) and beta-arrestin depend on a privileged AP2beta2 appendage site for proper cargo recruitment to clathrin bud sites. (nih.gov)
  • Cdh1 plays a pivotal role in controlling cell division at the end of mitosis (telophase) and in the subsequent G1 phase of cell cycle: By recognizing and binding proteins (like mitotic cyclins) which contain a destruction box (D-box) and an additional degradation signal (KEN box), Cdh1 recruits them in a C-box-dependent mechanism to the APC for ubiquination and subsequent proteolysis. (wikipedia.org)
  • CRL4A complexes regulate entry into the DNA synthesis phase, or S phase, of the mitotic cycle by regulating protein expression levels of the replication licensing factor protein Cdt1 and cyclin-dependent kinase inhibitor p21. (wikipedia.org)
  • The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. (nih.gov)
  • These receptors are classified into three subgroups based on sequence similarity and G protein coupling specificity. (biomedcentral.com)
  • Group I metabotropic glutamate receptors, (mGluR1 and mGluR5), regulate excitatory synaptic signaling response via their coupling to the heterotrimeric G protein, Gα q/11 , which upon activation stimulates the activity of the enzyme phospholipase C to generate the production of two second messengers, diacylglycerol and inositol 1, 4, 5 trisphosphate. (biomedcentral.com)
  • These subunits are present in different forms, their corresponding ligands classify these receptors into four groups: RGD receptors, laminin receptors, leukocyte-specific receptors and collagen receptors. (wikipedia.org)
  • Clathrin coats contain both clathrin (acts as a scaffold) and adaptor complexes that link clathrin to receptors in coated vesicles. (wikipedia.org)
  • While some of the details of how these adaptor proteins achieve their trafficking specificity has been worked out, there is still much to be learned. (wikipedia.org)
  • Cdh1 is one of the co- activator proteins of APC/c and therefore contributes to the regulation of protein degradation, by providing substrate specificity to the E3-ligase in a cell cycle regulated manner. (wikipedia.org)