A family of large adaptin protein subunits of approximately 100 kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2.
An adaptor protein complex found primarily on perinuclear compartments.
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.
An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.
The subunits that make up the large, medium and small chains of adaptor proteins.
A family of large adaptin protein subunits of approximately 130-kDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3.
A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.
A family of large adaptin protein subunits of approximately 90 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 1.
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size.
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.
The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)
A subclass of clathrin assembly proteins that occur as monomers.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL SURFACE RECEPTORS to MITOGEN-ACTIVATED PROTEIN KINASES.
A family of small adaptin protein complex subunits of approximately 19 KDa in size.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane.
Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. Shortly after formation, however, the clathrin coat is removed and the vesicles are referred to as ENDOSOMES.
Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.
Transport proteins that carry specific substances in the blood or across cell membranes.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Established cell cultures that have the potential to propagate indefinitely.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Vesicles that are involved in shuttling cargo from the interior of the cell to the cell surface, from the cell surface to the interior, across the cell or around the cell to various locations.
The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.
Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. These pits are the entry route for macromolecules bound by cell surface receptors. The pits are then internalized into the cytoplasm to form the COATED VESICLES.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Macromolecular complexes formed from the association of defined protein subunits.
A binding partner for several RECEPTOR PROTEIN-TYROSINE KINASES, including INSULIN RECEPTOR and INSULIN-LIKE GROWTH FACTOR RECEPTOR. It contains a C-terminal SH2 DOMAIN and mediates various SIGNAL TRANSDUCTION pathways.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.

AP-4, a novel protein complex related to clathrin adaptors. (1/230)

Here we report the identification and characterization of AP-4, a novel protein complex related to the heterotetrameric AP-1, AP-2, and AP-3 adaptors that mediate protein sorting in the endocytic and late secretory pathways. The key to the identification of this complex was the cloning and sequencing of two widely expressed, mammalian cDNAs encoding new homologs of the adaptor beta and sigma subunits named beta4 and sigma4, respectively. An antibody to beta4 recognized in human cells an approximately 83-kDa polypeptide that exists in both soluble and membrane-associated forms. Gel filtration, sedimentation velocity, and immunoprecipitation experiments revealed that beta4 is a component of a multisubunit complex (AP-4) that also contains the sigma4 polypeptide and two additional adaptor subunit homologs named mu4 (mu-ARP2) and epsilon. Immunofluorescence analyses showed that AP-4 is associated with the trans-Golgi network or an adjacent structure and that this association is sensitive to the drug brefeldin A. We propose that, like the related AP-1, AP-2, and AP-3 complexes, AP-4 plays a role in signal-mediated trafficking of integral membrane proteins in mammalian cells.  (+info)

High-affinity binding of the AP-1 adaptor complex to trans-golgi network membranes devoid of mannose 6-phosphate receptors. (2/230)

The GTP-binding protein ADP-ribosylation factor (ARF) initiates clathrin-coat assembly at the trans-Goli network (TGN) by generating high-affinity membrane-binding sites for the AP-1 adaptor complex. Both transmembrane proteins, which are sorted into the assembling coated bud, and novel docking proteins have been suggested to be partners with GTP-bound ARF in generating the AP-1-docking sites. The best characterized, and probably the major transmembrane molecules sorted into the clathrin-coated vesicles that form on the TGN, are the mannose 6-phosphate receptors (MPRs). Here, we have examined the role of the MPRs in the AP-1 recruitment process by comparing fibroblasts derived from embryos of either normal or MPR-negative animals. Despite major alterations to the lysosome compartment in the MPR-deficient cells, the steady-state distribution of AP-1 at the TGN is comparable to that of normal cells. Golgi-enriched membranes prepared from the receptor-negative cells also display an apparently normal capacity to recruit AP-1 in vitro in the presence of ARF and either GTP or GTPgammaS. The AP-1 adaptor is recruited specifically onto the TGN and not onto the numerous abnormal membrane elements that accumulate within the MPR-negative fibroblasts. AP-1 bound to TGN membranes from either normal or MPR-negative fibroblasts is fully resistant to chemical extraction with 1 M Tris-HCl, pH 7, indicating that the adaptor binds to both membrane types with high affinity. The only difference we do note between the Golgi prepared from the MPR-deficient cells and the normal cells is that AP-1 recruited onto the receptor-lacking membranes in the presence of ARF1.GTP is consistently more resistant to extraction with Tris. Because sensitivity to Tris extraction correlates well with nucleotide hydrolysis, this finding might suggest a possible link between MPR sorting and ARF GAP regulation. We conclude that the MPRs are not essential determinants in the initial steps of AP-1 binding to the TGN but, instead, they may play a regulatory role in clathrin-coated vesicle formation by affecting ARF.GTP hydrolysis.  (+info)

Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation. (3/230)

Cluster of differentiation antigen 4 (CD4), the T lymphocyte antigen receptor component and human immunodeficiency virus coreceptor, is down-modulated when cells are activated by antigen or phorbol esters. During down-modulation CD4 dissociates from p56(lck), undergoes endocytosis through clathrin-coated pits, and is then sorted in early endosomes to late endocytic organelles where it is degraded. Previous studies have suggested that phosphorylation and a dileucine sequence are required for down-modulation. Using transfected HeLa cells, in which CD4 endocytosis can be studied in the absence of p56(lck), we show that the dileucine sequence in the cytoplasmic domain is essential for clathrin-mediated CD4 endocytosis. However, this sequence is only functional as an endocytosis signal when neighboring serine residues are phosphorylated. Phosphoserine is required for rapid endocytosis because CD4 molecules in which the cytoplasmic domain serine residues are substituted with glutamic acid residues are not internalized efficiently. Using surface plasmon resonance, we show that CD4 peptides containing the dileucine sequence bind weakly to clathrin adaptor protein complexes 2 and 1. The affinity of this interaction is increased 350- to 700-fold when the peptides also contain phosphoserine residues.  (+info)

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. (4/230)

betaarrestins mediate the desensitization of the beta2-adrenergic receptor (beta2AR) and many other G protein-coupled receptors (GPCRs). Additionally, betaarrestins initiate the endocytosis of these receptors via clathrin coated-pits and interact directly with clathrin. Consequently, it has been proposed that betaarrestins serve as clathrin adaptors for the GPCR family by linking these receptors to clathrin lattices. AP-2, the heterotetrameric clathrin adaptor protein, has been demonstrated to mediate the internalization of many types of plasma membrane proteins other than GPCRs. AP-2 interacts with the clathrin heavy chain and cytoplasmic domains of receptors such as those for epidermal growth factor and transferrin. In the present study we demonstrate the formation of an agonist-induced multimeric complex containing a GPCR, betaarrestin 2, and the beta2-adaptin subunit of AP-2. beta2-Adaptin binds betaarrestin 2 in a yeast two-hybrid assay and coimmunoprecipitates with betaarrestins and beta2AR in an agonist-dependent manner in HEK-293 cells. Moreover, beta2-adaptin translocates from the cytosol to the plasma membrane in response to the beta2AR agonist isoproterenol and colocalizes with beta2AR in clathrin-coated pits. Finally, expression of betaarrestin 2 minigene constructs containing the beta2-adaptin interacting region inhibits beta2AR endocytosis. These findings point to a role for AP-2 in GPCR endocytosis, and they suggest that AP-2 functions as a clathrin adaptor for the endocytosis of diverse classes of membrane receptors.  (+info)

Inhibition of clathrin-coated pit assembly by an Eps15 mutant. (5/230)

Recent data have shown that Eps15, a newly identified component of clathrin-coated pits constitutively associated with the AP-2 complex, is required for receptor-mediated endocytosis. However, its precise function remains unknown. Interestingly, Eps15 contains three EH (Eps15-Homology) domains also found in proteins required for the internalization step of endocytosis in yeast. Results presented here show that EH domains are required for correct coated pit targeting of Eps15. Furthermore, when cells expressed an Eps15 mutant lacking EH domains, the plasma membrane punctate distribution of both AP-2 and clathrin was lost, implying the absence of coated pits. This was further confirmed by the fact that dynamin, a GTPase found in coated pits, was homogeneously redistributed on the plasma membrane and that endocytosis of transferrin, a specific marker of clathrin-dependent endocytosis, was strongly inhibited. Altogether, these results strongly suggest a role for Eps15 in coated pit assembly and more precisely a role for Eps15 in the docking of AP-2 onto the plasma membrane. This hypothesis is supported by the fact that a GFP fusion protein encoding the ear domain of (alpha)-adaptin, the AP-2 binding site for Eps15, was efficiently targeted to plasma membrane coated pits.  (+info)

ADP-ribosylation factor 1 dependent clathrin-coat assembly on synthetic liposomes. (6/230)

The assembly of clathrin-coated vesicles on Golgi membranes is initiated by the GTP-binding protein ADP ribosylation factor (ARF), which generates high-affinity membrane-binding sites for the heterotetrameric AP-1 adaptor complex. Once bound, the AP-1 recruits clathrin triskelia, which polymerize to form the coat. We have found that ARF.GTP also recruits AP-1 and clathrin onto protein-free liposomes. The efficiency of this process is modulated by the composition of the liposomes, with phosphatidylserine being the most stimulatory phospholipid. There is also a requirement for cytosolic factor(s) other than ARF. Thin-section electron microscopy shows the presence of clathrin-coated buds and vesicles that resemble those formed in vivo. These results indicate that AP-1-containing clathrin-coated vesicles can form in the absence of integral membrane proteins. Thus, ARF.GTP, appropriate lipids, and cytosolic factor(s) are the minimal components necessary for AP-1 clathrin-coat assembly.  (+info)

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. (7/230)

Although interactions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based internalization motifs have been implicated in the selective recruitment of cargo molecules into coated pits, the functional significance of this interaction for endocytosis of many types of membrane proteins remains unclear. To analyze the function of mu2-receptor interactions, we constructed an epitope-tagged mu2 that incorporates into AP-2 and is targeted to coated pits. Mutational analysis revealed that Asp176 and Trp421 of mu2 are involved in the interaction with internalization motifs of TGN38 and epidermal growth factor (EGF) receptor. Inducible overexpression of mutant mu2, in which these two residues were changed to alanines, resulted in metabolic replacement of endogenous mu2 in AP-2 complexes and complete abrogation of AP-2 interaction with the tyrosine-based internalization motifs. As a consequence, endocytosis of the transferrin receptor was severely impaired. In contrast, internalization of the EGF receptor was not affected. These results demonstrate the potential usefulness of the dominant-interfering approach for functional analysis of the adaptor protein family, and indicate that clathrin-mediated endocytosis may proceed in both a mu2-dependent and -independent manner.  (+info)

Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. (8/230)

We recently identified and cloned intersectin, a protein containing two Eps15 homology (EH) domains and five Src homology 3 (SH3) domains. Using a newly developed intersectin antibody, we demonstrate that endogenous COS-7 cell intersectin localizes to clathrin-coated pits, and transfection studies suggest that the EH domains may direct this localization. Through alternative splicing in a stop codon, a long form of intersectin is generated with a C-terminal extension containing Dbl homology (DH), pleckstrin homology (PH), and C2 domains. Western blots reveal that the long form of intersectin is expressed specifically in neurons, whereas the short isoform is expressed at lower levels in glia and other nonneuronal cells. Immunofluorescence analysis of cultured hippocampal neurons reveals that intersectin is found at the plasma membrane where it is co-localized with clathrin. Ibp2, a protein identified based on its interactions with the EH domains of intersectin, binds to clathrin through the N terminus of the heavy chain, suggesting a mechanism for the localization of intersectin at clathrin-coated pits. Ibp2 also binds to the clathrin adaptor AP2, and antibodies against intersectin co-immunoprecipitate clathrin, AP2, and dynamin from brain extracts. These data suggest that the long and short forms of intersectin are components of the endocytic machinery in neurons and nonneuronal cells.  (+info)

NACAP1 (nascent polypeptide associated complex alpha subunit pseudogene 1), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Arsenic atom in PDB 1r4x: Crystal Structure Analys of the Gamma-Copi Appendage Domain
These adapters are made from good quality parts and will meet the specifications similar to your laptop requirements. The adapters are BIS certified and thus confirms durability and performance. These adapters are equipped with protection circuit which protects your laptop.. COMPATIBLE MODEL:-. ...
VMware Tools for linux exists in 2 forms: the official VMware Tools and Open-VM-Tools. VMware Tools is based on a stable snapshot of Open-VM-Tools. Open-VM-Tools contains more experimental code and features. The official VMware Tools are not available for Archlinux. Originally, VMware Tools provided the best drivers for network and storage, combined with the functionality for other features such as time synchronization. However, for quite a while now the drivers for the network adapter en scsi adapter are part of the linux kernel, and VMware Tools is only needed for extra features and support for the old vmxnet adapter. ...
|p|For Adapter-On Gene Fragments, universal adapters are synthesized onto the ends of each fragment. The adapters are 21-22 nucleotides in length. Fragments with these adapters are compatible with a number of assembly methods, namely Restriction Digestion/Ligation, Gateway, Golden Gate, and TOPO cloning.|/p| |p|The addition of restriction sites inside of the adapters can be used to remove adapters. TOPO cloning will work but will leave the adapters on. |/p| |p| |/p| |p||strong|ADAPTER SEQUENCES|/strong||/p|
Previous work showed that UNC 101 and DPY 23 are adaptins orthologous to the mu1 and mu2 subunits of adaptor protein complex 1 and 2, and that they both can act as negative modulators of LET 23 Regorafenib chemical structure signalling. Similarly, SLI 1 is orthologous to CBL, an E3 ubiquitin ligase targeting LET 23 for degradation and SEM 5 is GRB2, an adaptor molecule that physically interact with EGFR. To address whether these genes could interact with cdt 2, we used loss of function alleles of dpy 23 AP2, unc 101 AP1, sli 1 CBL, and sem 5 GRB2 and performed cdt 2. We found that cdt 2 genetically interacts with dpy 23lf and unc 101lf, as cdt 2 RNAi induces a Muv phenotype in these back grounds. In contrast, no interaction was seen with sli 1lf or sem 5lf.. Since an absence of genetic interaction can sometimes suggest a physical interaction, we tested whether CDT 2 could physically interact with either SLI 1 or SEM 5. We produced in vitro labelled CDT 2 and puri fied SLI 1 and SEM 5 from ...
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The TA-8M4-10 Thread Adaptor converts 8-32 threads to M4. Thread adaptors are frequently used to allow two components with different threads to be used together...
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A word of caution on the DKL mount, many of the DKL to M42 or DKL to K mount adapters are priced in the $35 to $50 range many of them are poorly made with all sorts of failing issues after few usage. I ran through three DKL to M42 adapters to get one good one out of three. They all work initially and after a few mount, they lose the tight mounting or fail to lock the DKL lens into place. ...
A three-piece anastomotic coupling device for end-to-end anastomosis of tubular members consisting of two open bore cylindrical adaptors and an open bore cylindrical connector. Each end of a tubular member is passed through the axial bore of an adaptor and everted over the end thereof. The adaptors are then inserted into opposite ends of the connector until the everted ends of the vessel abut under light compression. Integral locking means are provided to secure the adaptors and tubular members of the connector piece.
The structure of the appendage domain of β2 adaptin is similar to that of α‐adaptin in that it has two subdomains with similar topology, but with a difference of ∼46° in the orientation between the two subdomains. Like the α‐appendage, the β2‐appendage domain binds AP180, epsin and eps15, and therefore is likely to be involved in recruiting proteins involved in controlling CCV formation to sites of coated pit formation in vivo. The two proteins possess a partly conserved binding site of high hydrophobic potential on the C‐terminal platform domain, suggesting that they bind similar motifs i.e. DΦF/W. The binding site residues are also conserved in β1‐adaptin from the adaptor AP1, so this homologue would be predicted to bind the same ligands as β2. Indeed, a GSTβ1 appendage construct does bind to eps15, and weakly to clathrin and epsin (data not shown). Although the α and β2 appendages share some of the same ligands, they bind to them with different relative affinities: the ...
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Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves …
SCYL1 binds COP1 vesicles that mediate retrograde Golgi-to ER transport, through an SCYL1-specific RKLD motif at the extreme C terminus [2]. Knockdown of SCYL1 disrupts Golgi morphology and blocks retrograte COPI-mediated transport from Golgi to ER [3]. The Golgi-localized Gorab protein (aka NTKL-BP1, SCYL-BP1) was found as a interactor of mouse Scyl1 by Y2H and coIP [4]. The yeast SCYL1, Cex1, also has several trafficking-associated physical and genetic interactors, including YPT6 (Golgi fusion of late endosome vesicles), COG5 and COG6 (fusion of vesicles to Golgi), several COPI complex members (COP1, SEC27, SEC29, RET2, UBP5 and BRE5 (ER-Golgi transport), and RGP1 and RIC1 (Golgi-to-ER transport) (BioGrid). SCYL2 appears to act a a different point in trafficking - the endocytosis and trafficking of surface proteins. Human SCYL2 (aka CVAK104) binds clathrin and the plasma membrane adaptor complex, AP2 [5]. Yeast SCYL2 (Cex1) was also found in a genetic screen for modifiers of a clathrin mutant ...
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Tor2 is an activator of the Rom2/Rho1 pathway that regulates α-factor internalization. Since the recruitment of endocytic proteins such as actin binding proteins and the amphiphysins precedes the internalization of α-factor, I hypothesized that loss of Tor function leads to an alteration in the dynamics of the endocytic proteins. I report here that endocytic proteins, Abp1 and Rvs167, are less recruited to endocytic sites not only in tor2 but also tor1 mutants. Furthermore, I found that the endocytic proteins Rvs167 and Sjl2 are completely mistargeted to the cytoplasm in tor1∆tor2ts double mutant cells. I also demonstrate here that the efficiency of endocytic internalization or scission in all tor mutants was drastically decreased. In agreement with the Sjl2 mislocalization, I found that in tor1∆tor2ts double mutant cells, as well as other tor mutant cells, the overall PIP2 level was dramatically increased. Finally, the cell wall chitin content in tor2ts and tor1∆tor2ts mutant cells was also
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Walds 10252 training wheels are designed to mount on most single speed bicycles with 16- to 20-inch wheels and are intended for use by riders weighing up to 100 pounds. These training wheels feature new frame adapters that improve installation. The new frame adapters enable this wheel set to be mounted on bicycles with .75 and 1.00-inch rear frame tubes. The training wheels can also be mounted onto bicycles with 1.25-inch rear frame tubes when the frame adapters are not used ...
Walds 10252 training wheels are designed to mount on most single speed bicycles with 16- to 20-inch wheels and are intended for use by riders weighing up to 100 pounds. These training wheels feature new frame adapters that improve installation. The new frame adapters enable this wheel set to be mounted on bicycles with .75 and 1.00-inch rear frame tubes. The training wheels can also be mounted onto bicycles with 1.25-inch rear frame tubes when the frame adapters are not used ...
The endocytic pathway is essential for cell homeostasis and numerous small GTPase Rab have been involved in its control. The endocytic trafficking step controlled by Rab4b has not been elucidated although recent data suggested it could be important for glucose homeostasis, synaptic homeostasis, or adaptative immunity. Here we show that Rab4b is required for early endosome sorting of transferrin receptors (TfR) to the recycling endosomes and we identified the AP1γ subunit of the clathrin adaptor AP-1 as a Rab4b effector and key component of the machinery of early endosomes sorting. We show that internalized transferrin (Tf) does not reach Vamp3/Rab11 recycling endosomes in absence of Rab4b while it is rapidly recycled back to the plasma membrane. On the contrary, Rab4b overexpression leads to the accumulation of internalized Tf within AP-1 and clathrin-coated vesicles. These vesicles are poor in early and recycling endocytic markers except TfR and require AP1γ for their formation. Furthermore, ...
EpsinR is a clathrin-coated vesicle (CCV) enriched 70-kD protein that binds to phosphatidylinositol-4-phosphate, clathrin, and the gamma appendage domain of the adaptor protein complex 1 (AP1). In cells, its distribution overlaps with the perinuclear pool of clathrin and AP1 adaptors. Overexpression disrupts the CCV-dependent trafficking of cathepsin D from the trans-Golgi network to lysosomes and the incorporation of mannose-6-phosphate receptors into CCVs. These biochemical and cell biological data point to a role for epsinR in AP1/clathrin budding events in the cell, just as epsin1 is involved in the budding of AP2 CCVs. Furthermore, we show that two gamma appendage domains can simultaneously bind to epsinR with affinities of 0.7 and 45 microM, respectively. Thus, potentially, two AP1 complexes can bind to one epsinR. This high affinity binding allowed us to identify a consensus binding motif of the form DFxDF, which we also find in gamma-synergin and use to predict that an uncharacterized EF-hand
When released from the 20°C block, VSVG emigrated away from membranes positive for conventional Golgi to closely apposed structures that were positive for AP-1B and Exo70. Intriguingly, Exo70 also strongly localized to Tfn- and TfnR-positive recycling endosomes. Thus, it seems possible that AP-1B-dependent cargo may at least partially enter recycling endosomes before continuing to the plasma membrane after exit from the Golgi. Our data are thus in agreement with previous observations showing that Rab11 (a recycling endosome-associated GTPase) may play a role in biosynthetic traffic, at least in nonpolarized cells (Chen et al., 1998). Moreover, both the TGN and recycling endosomes are complex sorting compartments (Mellman and Warren, 2000). In the case of epithelial cells, it is also interesting to note that polarized targeting of newly synthesized and recycling glycoproteins makes use of similar or identical sorting determinants in the TGN and in the endocytic pathway (Matter et al., 1993; ...
Looking for online definition of Golgi adaptor HA1/AP1 adaptin sigma-1C subunit in the Medical Dictionary? Golgi adaptor HA1/AP1 adaptin sigma-1C subunit explanation free. What is Golgi adaptor HA1/AP1 adaptin sigma-1C subunit? Meaning of Golgi adaptor HA1/AP1 adaptin sigma-1C subunit medical term. What does Golgi adaptor HA1/AP1 adaptin sigma-1C subunit mean?
TY - JOUR. T1 - Inhibition of the interaction between tyrosine-based motifs and the medium chain subunit of the AP-2 adaptor complex by specific tyrphostins. AU - Crump, CM. AU - Williams, JL. AU - Stephens, DJ. AU - Banting, G. PY - 1998. Y1 - 1998. M3 - Article (Academic Journal). VL - 273. SP - 28073. EP - 28077. JO - Journal of Biological Chemistry. JF - Journal of Biological Chemistry. SN - 0021-9258. ER - ...
Characterization of clathrin-coated vesicles isolated from MPR-deficient fibroblasts. The material contained in fractions 8 to 10 of the density gradients sho
Looking for coated pit? Find out information about coated pit. A cell surface depression that is coated with clathrin on its cytoplasmic surface and functions in receptor-mediated endocytosis Explanation of coated pit
Crk family adaptors are widely expressed and mediate the timely formation of signal transduction protein complexes upon a variety of extracellular stimuli, including various growth and differentiation factors. Selective formation of multi-protein complexes by the Crk and Crk-like (CRKL) proteins dep …
At the time of writing, the latest Intel driver version is 15.1.1 and it is unusable for packet capturing. TamoSoft notified Intel about this bug on November 1, 2011. Intel acknowledged the bug, but refused to fix it. If your driver version is affected, please download and install version 13.5.0.0 (these are original, signed Intel installation files):. Intel Wi-Fi Drivers for Windows 7 and 8 (32-bit). Intel Wi-Fi Drivers for Windows 7 and 8 (64-bit). Intel Wi-Fi Drivers for Windows Vista (32-bit). Intel Wi-Fi Drivers for Windows Vista (64-bit). Intel 1000, 3945, 4965, 5100, 5150, 5300, 5350, 6200, 6250, 6300, 6350 adapters are NOT supported on Windows 10.. ...
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Satechi today announced an expansion of its Type-C accessory line, introducing the new Slim 4K Multi-Port USB-C Adapter. The Slim Multi-Port Adapter...
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If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
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Please make sure the part number Please make sure the part number, series number and model number are all matching your original adapter.
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Caribherp contains information on amphibians and reptiles of the Caribbean Islands (West Indies). It serves as a checklist of what occurs in the region as well as a quick identification guide to the species. Approximately 2000 images and maps, and selected frog calls (sounds), are presented along with an integrated open-access journal, Caribbean Herpetology. The journal accepts color images and video and currently publishes brief communications on individual species-later volumes will include full research articles. The species accounts can be sorted in many ways. About 750 species are recognized from the region and covered here.
Human 100 kDa coated vesicle protein A ELISA Kit;Human adaptor protein complex AP-2 subunit alpha-1 ELISA Kit;Human adaptor-related protein complex 2 subunit alpha-1 ELISA Kit;Human alpha-adaptin A ELISA Kit;Human alpha1-adaptin ELISA Kit;Human clathrin assembly protein complex 2 alpha-A large chain ELISA Kit;Human plasma membrane adaptor HA2/AP2 adaptin alpha A subunit ELISA Kit;Human ADTAA ELISA Kit;Human CLAPA1 ELISA Kit;Human AP2-ALPHA ELISA Kit;Human adaptor related protein complex 2 alpha 1 subunit ELISA Kit;Human AP-2 complex subunit alpha-1 ELISA Kit;Human adapter-related protein complex 2 alpha-1 subunit ELISA Kit;Human adapter-related protein complex 2 subunit alpha-1 ELISA Kit;Human adaptin, alpha A ELISA Kit;Human clathrin-associated/assembly/adaptor protein, large, alpha 1 ELISA Kit ...
The AP-complex family (Boehm and Bonifacino, 2001; Nakatsu and Ohno, 2003; Owen et al., 2004; Robinson, 2004) has six members in mammals. AP-1A, AP-2, AP-3A and AP-4 are ubiquitously expressed. The other two members, AP-5 and AP-6, are cell-type-specific isoforms of AP-1A and AP-3A: the epithelium-specific AP-1B and the neuron-restricted AP-3B.. The AP complexes consist of four subunits: one small (σ1-σ4), one medium (μ1-μ4) and two large (α, γ, δ or ϵ; and β1-β4) subunits. These assemble to form a structure in which two appendage domains are connected by flexible hinge regions to the core (Owen et al., 2004; Owen and Luzio, 2000; Robinson, 2004). The large subunits are divided into three domains: the N-terminal domain, which makes up the core with the μ and σ subunits; the hinge domain, and the C-terminal appendage. One of the large subunits (α, γ, δ or ϵ) is implicated in binding to the target membrane (Collins et al., 2002; Nakatsu and Ohno, 2003; Owen et al., 2004; Traub, ...
During clathrin-mediated endocytosis, it has been thought that the sensing and binding of the clathrin adaptor protein AP2 to cargo and lipids leads to the recruitment of clathrin, nucleating the formation of a clathrin-coated pit. Henne et al. have now found that this process of AP2 binding may not in fact represent either the first or the nucleation event of endocytosis. Instead, ubiquitous proteins called FCHo1/2 (F-BAR proteins) bind to the plasma membrane and define the sites of endocytosis independently of AP2. The F-BAR protein can generate very low curvatures and, at higher concentrations, generates higher curvatures like those required at the neck of budding vesicles. The C terminus of the protein has a μ-homology domain (with homology to the μ domain of the AP2 complex) that interacts with Eps15 and intersectin and via these proteins recruits AP2, which further recruits clathrin. Thus, a curvature-inducing protein can act to nucleate clathrin-coated pit assembly during ...
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I am wondering how the removal of adaptor sequences will impact the transcriptome assembly. For example, in 10% of my reads contain adaptors which are not removed. If I try to assemble the transcriptome, will some of my unigene dataset contain adaptors? Besides, will the result be different if I use a genome-guided or de novo asssembly method?. ...
Theres also focus issues with lens adapters as you have 3 potential places for de-focus: the front lens, the back focus on the adapter, and the stock lens. When youre running and gunning, this can really slow things down. If I can have it my way, Im going to burden my brain with as few hardware related thoughts as possible so I can focus on making effective creative decisions. I think Lens Adapters are a great solution but can also be a lot of headaches (and back aches!). Because the Pro35 bypasses the stocks lens and has such precise controls, I found it to be a lot more comfortable to operate and with less things to worry my brain about. With the Zacuto plate, shoulder pad, and handles, the rig effortlessly went from studio mode to handheld as fast as we could get it off the sticks. That was awesome. Definitely the biggest issue with this setup is the crop factor. Without a real relay lens, your 18mm is more like a 35 or a 40. Thats wide but not really wide enough in a tight space or if ...
The M.2 to mini PCIe adapter adapter is designed to convert a cellular M.2 card (key B) to be used in a full or half sized mPCIe card slot. This adapter has two SIM card holders and supports USB2.0. Please observe! When using generic 3rd party adapters with 5G cellular data card modules, always ensure compatibility for pin-out definitions, signal voltage level, and power output capabilities for your selected cellular module, the adapter and host board prior to using the adapters. Failure to do so can result in malfunctioning systems or hardware damage to the parts. Available variants: M2BU3S-U2D V3.0
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GoPro™-adapter for ski poles. For mounting the original GoPro™ support on the grip. Compatible with these models: 6366872, 6366870, 6362707, 636685...
Its hard to deny that USB-C has become a standard for charging and data transfer. Here we go through some of the best USB-C cables, chargers and adapters for MacBooks and Macs
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"Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit". Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH ... AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene. AP2A2 has been shown to interact with ... Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of ... the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes ...
... either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ... "Entrez Gene: SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)". Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein ... 1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". J. Biol. Chem. 273 (47 ... 1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 ( ... "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module". J ...
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ... AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene. ...
... and some of the adapter proteins, such as talin, paxillin and tensin. Many of these focal complexes fail to mature and are ... Integrins are heterodimers which are formed from one beta and one alpha subunit. These subunits are present in different forms ... bind to and associate with this integrin-adapter protein-cytoskeleton complex, and this forms the basis of a focal adhesion. ... However, some focal complexes mature into larger and stable focal adhesions, and recruit many more proteins such as zyxin. ...
The family routinely lies on the clathrin adaptor complex 3 beta-1 subunit proteins. The exact function of DUF 1682 is unclear ... The C-terminal portion of the protein is highly charged and its secondary structure is predicted to be that of an alpha helix ... The final protein is thought to be translated from the endoplasmic reticulum into the cytoplasm of the cell. The protein is ... The portion of the protein which extends into the cytosol is predicted to be highly phosphorylated as the protein's ...
"Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit". Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, ... adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor ... AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene. This gene encodes a subunit of the ... heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The ...
AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). ... For example, in AP1 these subunits are gamma-1-adaptin, beta-1-adaptin, mu-1 and sigma-1, while in AP2 they are alpha-adaptin, ... Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
... proteins or receptors named A1 or Alpha-1 : Actin, alpha 1 Actinin, alpha 1 Adaptor-related protein complex 2, alpha 1 Aldehyde ... alpha 1 Proteasome (prosome, macropain) subunit, alpha 1 Protein kinase, AMP-activated, alpha 1 Protein tyrosine phosphatase, ... alpha 1 Gap junction protein, alpha 1 GDNF family receptor alpha 1 Glutathione S-transferase A1 Glycine receptor, alpha 1 Heat ... alpha 1 Major histocompatibility complex, class II, DP alpha 1 Major histocompatibility complex, class II, DQ alpha 1 Myosin ...
T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or [email protected] It contributes ... "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299- ... 2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an ... 2001). "Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits". Mol. ...
The other large protein has different designations in the different complexes. In AP-1 it is named γ (gamma), AP-2 has α (alpha ... The two smaller proteins are a medium subunit named μ (mu ∼50 kD) and a small subunit σ (sigma ∼20 kD), and named 1 through 5 ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (∼100 kD) and two smaller ... Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ...
... the plasma membrane the TCR receptor chains α and β associate with six additional adaptor proteins to form an octameric complex ... The TCR is a disulfide-linked membrane-anchored heterodimeric protein normally consisting of the highly variable alpha (α) and ... in the transmembrane domain of each subunit form polar interactions allowing a correct and stable assembly of the complex. The ... LAT associates with another scaffolding protein Slp-76 via the Grap2 adaptor protein, which provides additional binding sites. ...
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... in AP1 these subunits are gamma-1-adaptin, beta-1-adaptin, mu-1 and sigma-1, while in AP2 they are alpha-adaptin, beta-2- ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This ... The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. ... "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". Rost, Martina; Döring Tatjana; Prange Reinhild (Nov ... AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene. Adaptins are important components ...
The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two ... The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. ... "Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit". Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999 ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ...
... of rRNA processing Protein Phosphorylation Ribosomal small subunit biogenesis RIOK1 is the only component of the PRMT5 complex ... used as a basis for synthesis of a macrocyclic inhibitor of protein-protein interactions between PRMT5 and its adaptor proteins ... modifications the protein Kinase RIO1 has 2 phosphoserines in positions 21 and 22 Its secondary structure consist of 9 alpha ... 6:7,389,496-7,418,037) Effects on modified protein - protein degradation, triggered by K411-m1; protein stabilization, ...
... is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 ( ... 2000). "Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation". J. Biol. Chem. 275 ... Timsit YE, Miller SL, Mohney RP, O'Bryan JP (2005). "The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ... Epsin-1 is a protein that in humans is encoded by the EPN1 gene. ... as well as with other accessory proteins for the endocytosis of ...
The coatomer protein complex is made up of seven nonidentical protein subunits. These seven nonidentical protein subunits are ... allowing it to insert an amphipathic alpha helix into the lipid bilayer of the Golgi complex. Next, the ARF1 protein recruits ... Coatomers are functionally analogous and evolutionarily homologous to clathrin adaptor proteins, also known as adaptins, which ... The Sar1-GTP and Sec23-24 complex recruits another protein complex called Sec13/Sec31. This complex polymerizes to form the ...
All ATP-dependent chromatin-remodeling complexes possess a sub unit of ATPase that belongs to the SNF2 superfamily of proteins ... hADA3 may act as an adaptor protein linking transcription factors with other HAT complexes. In the absence of hADA3, TP53 ... factor implicated in the tumorigenesis and progression of breast cancer via its binding to the estrogen receptor alpha (ERα). ... ATP-dependent chromatin remodeling complexes. Specific protein complexes, known as histone-modifying complexes catalyze ...
AP1S2: AP-1 complex subunit sigma-2. Adaptor protein complex 1 is found on the cytoplasmic face of vesicles located at the ... GDI1: RabGDI alpha makes a complex with geranylgeranylated small GTP-binding proteins of the Rab family and keeps them in the ... "AP1S2 adaptor-related protein complex 1, sigma 2 subunit". Entrez Gene. National Center for Biotechnology Information, U.S. ... December 2006). "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked ...
Each molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and ... another multisubunit protein that is essential for mitosis, and a cargo adaptor. The tri-complex, which includes dynein, ... One attached alpha-helix from the stalk is pulled by the buttress, sliding the helix half a heptad repeat relative to its ... The dynactin complex is composed of more than 20 subunits, of which p150(Glued) is the largest. There is no definitive evidence ...
In contrast to IL-31RA, which binds SHP-2, the OSMR interacts with the adaptor protein Shc via the phosphorylated tyrosines on ... IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. ... The receptor for IL-31 is a heterodimer of the interleukin 31 receptor alpha (IL-31RA) and OSMR. IL-31RA was originally ... These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31RA binds IL-31 through ...
"Entrez Gene: AP3B2 adaptor-related protein complex 3, beta 2 subunit". Human AP3B2 genome location and AP3B2 gene details page ... Dubois T, Zemlickova E, Howell S, Aitken A (2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochem ... AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene. GRCm38: Ensembl release 89: ... 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". EMBO J. 16 (5): 917-28. doi:10.1093/emboj/16.5.917. ...
... encoding protein Serine incorporator 3 SHLD1: encoding protein Shieldin complex subunit 1 SLC17A9: encoding protein Solute ... encoding protein Transmembrane prostate androgen-induced protein TTPAL: encoding protein Tocopherol (alpha) transfer protein- ... encoding protein Kizuna centrosomal protein Kua-UEV: LIME1: encoding protein Lck-interacting transmembrane adapter 1 LZTS3: ... encoding protein Zinc finger protein 334 ZNF343: encoding protein Zinc finger protein 343 ZSWIM3: encoding protein Zinc finger ...
The DDB1 adaptor protein was initially characterized as the large subunit of a heterodimeric complex (UV-DDB) that was found to ... CUL4A protein is 759 amino acids long and forms an extended, rigid structure primarily consisting of alpha-helices. At the N- ... DDB2 is a DCAF protein and is both a ubiquitination substrate of the CRL4 complex and also serves as an E3 ligase protein for ... The smaller subunit of this Damaged DNA Binding protein complex is known as DDB2 and is able to directly bind DNA lesions ...
... s feature prominently in the proteins making up the nuclear pore complex (NPC); alpha solenoid and beta propeller ... and its adaptor protein importin alpha is an alpha solenoid formed from Armadillo repeats. Transporters of other molecules, ... For example, regulatory subunit A (also known as PR65) of protein phosphatase 2A is a HEAT-repeat alpha solenoid whose ... "alpha alpha superhelix". The CATH database uses the term "alpha horseshoe" for these proteins, and uses "alpha solenoid" for a ...
... consists of seven subunits which compose the heteroheptameric protein complex. The primary function of adaptors is the ... is made ARF binds to the cytosolic side of the cis-Golgi membrane and inserts the myristoylated N-terminal amphipathic alpha- ... COPI is a coatomer, a protein complex that coats vesicles transporting proteins from the cis end of the Golgi complex back to ... The order in which adaptor proteins associate with cargo, or adaptor proteins associate with ARFs is unclear, however, in order ...
"Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by ... "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Molecular Carcinogenesis. 38 (2): 85-96. doi:10.1002/mc. ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library ... Breen GA, Jordan EM (Aug 1999). "Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by ...
α {\displaystyle \alpha } -catenin is engaged by p120-catenin complex, where vinculin is recruited to take a role in indirect ... The adaptor proteins that associate with desmosomal cadherins are plakoglobin (related to β {\displaystyle \beta } -catenin), ... The functionality of cadherins relies upon the formation of two identical subunits, known as homodimers. The homodimeric ... Regulatory proteins include p-120 catenin, α {\displaystyle \alpha } -catenin, β {\displaystyle \beta } -catenin, and vinculin ...
"PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 ... Lou X, Yano H, Lee F, Chao MV, Farquhar MG (2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein ... "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse ... "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 ...
Homotrimerisation is a process whereby three of the same subunits, associate to make a complex of three identical YadA proteins ... Function: The function of the neck domain is to be the adaptor between the larger diameter of the beta-helices and the smaller ... Hence, the stalk domains can be considered alpha helical coiled-coils that deviate from the standard model due to their unusual ... Protein pages needing a picture, Protein families, Protein domains, Virulence factors, Gram-negative bacteria, Secretion, ...
The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated. GRCh38 ... 1996). "Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI ... 2002). "Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells". ... Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for ...
"Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined ... "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. ... Riordan SM, Lidder S, Williams R, Skouteris GG (2000). "The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF ... Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This ...
... and CUL4B-based E3 ubiquitin ligase complexes. DDB1 serves as a bridge or adaptor protein which interacts with dozens of ... 2002). "The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 ... 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97 ... The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of a large and a small (DDB2) ...
The calcium channel consists of a complex of alpha-1, alpha-2/delta and beta subunits in a 1:1:1 ratio. The S3-S4 linkers of ... alpha 1C subunit (also known as Cav1.2) is a protein that in humans is encoded by the CACNA1C gene. Cav1.2 is a subunit of L- ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library ... "A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit". FEBS Letters. 384 ...
... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell ... The function of the amino-terminal domain is less clear, but it has been shown to interact with the beta-1 integrin subunit in ... PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by ...
These changes facilitate the recruitment of specific adapter proteins such as the insulin receptor substrate proteins (IRS) in ... glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit". ... Strictly speaking the relationship between IR and ligand shows complex allosteric properties. This was indicated with the use ... "Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin ...
The DAP3 gene encodes a 46 kDa protein located in the lower area of the small mitoribosomal subunit. This protein contains a P- ... Miyazaki T, Reed JC (Jun 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nature ... As part of the mitoribosome, DAP3 participates in the translation of the 13 ETC complex proteins encoded in the mitochondrial ... Heat shock protein 90kDa alpha (cytosolic), member A1, and TNFRSF10A. GRCh38: Ensembl release 89: ENSG00000132676 - Ensembl, ...
Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene. Actin-binding protein, or filamin, is a 280-kD ... as a binding partner of human Lnk adaptor protein". Mol. Immunol. 37 (10): 603-12. doi:10.1016/s0161-5890(00)00070-5. PMID ... subunits". J. Cell Biol. 156 (2): 361-76. doi:10.1083/jcb.200103037. PMC 2199218. PMID 11807098. Loo DT, Kanner SB, Aruffo A ( ... transmembrane receptor complexes, and secondary messengers. At least 31 disease-causing mutations in this gene have been ...
Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, ... "The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101". Cell. 89 (1): 105-14. doi:10.1016 ... The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a ... One of the major functions of Gβγ is the inhibition of the Gα subunit. The individual subunits of the G protein complex were ...
"Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels". Science. 243 ( ... His first research project was to test the adaptor hypothesis of Francis Crick. He worked in the laboratory of Melvin Simpson, ... "Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS". Science. 278 (5345): 1907- ... "Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase". Science. 229 ...
"Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein ... a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in ... Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A (April 2001). "alpha 7 nicotinic receptor ... The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. ...
"Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined ... "A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex". ... Seifert RA, Hart CE, Phillips PE, Forstrom JW, Ross R, Murray MJ, Bowen-Pope DF (May 1989). "Two different subunits associate ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ...
... complexes that catalyse the assembly of amino acids into proteins according to the messenger RNA The adaptor molecules were ... This theoretical result matched well with X-ray data for proteins that contain sequences of amino acids in the alpha helix ... Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 ... Many molecular biologists were puzzled by the problem of the origin of a protein replicating system that is as complex as that ...
The binding of lipophilic protein complex to the host membrane facilitates the interaction of this three protein complex with ... and the large protein (L) that is a catalytic subunit of this polymerase. C-protein, which is translated from an alternative ... "An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon ... Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN (April 2013). "The adaptor MAVS promotes NLRP3 mitochondrial ...
ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ... Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, Kumar R (February 2004). "p41-Arc subunit of human Arp2/3 complex is a p21- ... Estrogen receptor-alpha-S305, signal transducer and activator of transcription 5a-S779, C-terminal binding protein 1-S158, Raf1 ... Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, Kumar R (February 2004). "p41-Arc subunit of human Arp2/3 complex is a p21- ...
IL-17RA/RC receptor complex is composed of both alpha helices and beta sheets and its extracellular part contains two ... such as Act1 or TRAF proteins. Binding of these signaling adaptors triggers activation of several signaling pathways, including ... Another family subunit IL-17RE is highly expressed in Th17 cells. Signaling via IL-17R protects our body against several ... IL-17RB binds preferentially IL-17B and IL-17E and heteromeric IL-17RA/RE complex binds IL-17C. However, there is still unknown ...
In response to IFN, this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9) and form ISGF-3 ... "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". The Journal of ... Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be ... Gupta S, Jiang M, Pernis AB (October 1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B ...
Then, the MNase-antibody complex is added. And finally, the protein-DNA complex can be isolated, with the DNA being ... ATAC-seq uses a hyperactive transposase to insert transposable markers with specific adapters, capable of binding primers for ... Noll M (September 1974). "Subunit structure of chromatin". Nature. 251 (5472): 249-51. Bibcode:1974Natur.251..249N. doi:10.1038 ... "Nucleosome phasing and micrococcal nuclease cleavage of African green monkey component alpha DNA". Proceedings of the National ...
... are recognised by the importin alpha protein, which then associates with importin beta and the nuclear pore complex to transfer ... VIP1 also appears to be an important protein in the process, possibly acting as an adapter to bring the VirE2 to the importin. ... The subunit is circularized by the formation of a peptide bond between the two ends of the polypeptide. Products of the other ... Then the VirA protein phosphorylates the VirG protein on its aspartate residue. The virG protein is a cytoplasmic protein ...
Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many ... activated DP2 triggers Gi alpha subunit-linked heterotrimeric G proteins to dissociate into their component a) ... clathrin and clathrin adaptor AP2, of the receptor internalization machinery. These pathways render DP2 unable to mobilize ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...
... which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These ... "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal ...
... is a 23 subunit protein complex that acts as a co-factor for the microtubule motor cytoplasmic dynein-1. It is built ... These proteins form long bundles of alpha helices, which wrap over each other and contact the Arp1 filament. The N-termini of ... "Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes". Science. 345 (6194): 337-41. Bibcode:2014Sci... ... The pointed end complex (PEC) has been shown to be involved in selective cargo binding. PEC subunits p62/DCTN4 and Arp11/Actr10 ...
Solution structure of the alpha adaptinC2 domain from human Adapter-related protein complex 1 gamma 2 subunit. ... AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and ... The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric ... CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, IN COMPLEX WITH AN FXDNF PEPTIDE FROM ...
... either by coupling itself with an adapter protein (e.g., importin-alpha subunit which binds to nuclear localization signals ( ... Importin subunit beta-1, Importin-90, Karyopherin subunit beta-1, Nuclear factor p97, Pore targeting complex 97kDa subunit, ... The KPNB1 protein is engaged in nuclear protein import, ... KPNB1 protein solution (0.25mg/ml) containing 20mM Tris-HCl ... docking of the importin/substrate complex to the nuclear pore complex).. Description. KPNB1 Human Recombinant produced in E. ...
Adaptor-Related Protein Complex 2, alpha 2 Subunit): * AP2A2 Anticorps AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit ... Protéines structurelles du SARS-CoV-2 : SARS-CoV-2 Spike Protein, SARS-CoV-2 Nucleocapsid Protein, SARS-CoV-2 S1 (RBD) Protein ... ATP5L (ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G): * ATP5L Anticorps ... GNB1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1): * GNB1 Anticorps ...
2003; ALPHA-ADAPTINS (now ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS) was indexed under CARRIER PROTEINS & MEMBRANE PROTEINS 1989- ... Adaptin, alpha. Clathrin Assembly Protein Complex alpha Subunit. Clathrin Assembly Protein Complex alpha Subunits. alpha ... Adaptin, alpha alpha Adaptin alpha Adaptins alpha-Adaptins Clathrin Assembly Protein Complex alpha Subunit - Narrower Concept ... Adaptor Protein Complex alpha Subunits - Preferred Concept UI. M0163813. Scope note. A family of large adaptin protein subunits ...
Adaptor Protein Complex alpha Subunits 100% * Neurofibrillary Tangles 65% * Protein Isoforms 43% ... Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes. Sands, M., Frank, J. A., Maglinger, B., ... Plasma protein alterations during human large vessel stroke: A controlled comparison study. Hazelwood, H. S., Frank, J. A., ... Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimers disease. Srinivasan, S., Gal, J., ...
ADTAB, Alpha adaptin C, Alpha2 adaptin, AP 2 complex subunit alpha 2, AP2A2, CLAPA2, HIP 9, HIP9, Huntingtin yeast partner J, ... Alpha adaptin is a subunit of the plasma membrane adaptor. It binds polyphosphoinositides. ... Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to ... Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. ...
IGF-1R is a heterotetrameric receptor tyrosine kinase (RTK) composed of two alpha and two beta subunits (Fig. 1). Both IGF-1 ... and plays a key role in protein synthesis and cell growth by regulating the activity of the TORC1 complex through a series of ... leading to the creation of multiple docking sites for the adaptor proteins IRS-1, IRS-2, and Shc. IRS-1 and IRS-2 binding ... leading to the creation of multiple docking sites for the adaptor proteins IRS-1, IRS-2, and Shc. IRS-1 and IRS-2 binding ...
Adaptor Protein Complex alpha Subunits .. Adaptin, alpha .. Clathrin Assembly Protein Complex alpha Subunit .. alpha Adaptin . ... Adaptor Protein Complex Subunits .. Adaptor Protein Subunits .. Clathrin Assembly Protein Subunits .. 0.83. ... D12.776.543.990.150.500 Adaptor Protein Complex Subunits .. D12.776.543.990.150.500.100 Adaptor Protein Complex alpha Subunits ... Adaptor Proteins, Vesicular Transport .. Adaptor Protein Complexes, Vesicular Transport .. Clathrin Adaptor Protein Complexes . ...
A kinase (PRKA) anchor protein 7. U: 1. AP2A2. adaptor-related protein complex 2, alpha 2 subunit. U: 1 ... protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I). U: 2 ... Results for query: protein domain specific binding. Gene Symbol. Gene Name. Links to Senescence. ... tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide. U: 2 ...
adaptor-related protein complex 2, alpha 1 subunit. 0.087. QARS. glutaminyl-tRNA synthetase. 0.085. ... guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1. 0.013. ... thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian). 0.023. ...
A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a ...
... and lysosomal protein trafficking are vital parasite-specific processes that involve the action of the adaptor complexes AP-1 ... was associated with the alpha subunit of AP-2, clathrin and ubiquitin and was involved in receptor-mediated endocytosis. It ... adaptor proteins, which are implicated in endocytosis and Golgi-to-endosome protein trafficking, respectively, in other ... In this study, we showed evidence suggesting that GlENTHp might function as a monomeric adaptor protein supporting the findings ...
... adaptor related protein complex 1 sigma 2 subunit (AP1S2), PHD finger protein 21A (PHF21A), lipoma preferred partner (LPP), and ... transcription factor AP-2 alpha (TFAP2A) showed similar expression patterns in OA FLS and OA synovial tissue datasets in Gene ... Exosomal protein from PTECs treated with high glucose (HG) was purified and examined using liquid chromatography-tandem mass ... The CRISPR systems usually require a guide RNA (gRNA) moiety to recruit and direct the nuclease complexes. In this respect, the ...
BCKDHA: branched chain keto acid dehydrogenase E1 subunit alpha. *BCKDHB: branched chain keto acid dehydrogenase E1 subunit ... BMPR1A: bone morphogenetic protein receptor type 1A. *BMPR2: bone morphogenetic protein receptor type 2 ... BCS1L: BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone. *BDNF: brain derived neurotrophic factor ... BICD2: BICD cargo adaptor 2. *BIN1: bridging integrator 1. *BLM: BLM RecQ like helicase ...
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. 0.7772. 39. ATP5MG. ATP synthase membrane subunit g. 0.7754. 39. ... Formation of mitochondrial complex V assembly factor 1 homolog. 0.7702. 39. PROTEIN EXPRESSION OVERVIEWi Protein expression ... Crystallin alpha B. 0.7895. 39. ATP6V1D. ATPase H+ transporting V1 subunit D. 0.7825. 39. ... Evidence at protein level. Protein expressioni A summary of the overall protein expression pattern across the analyzed normal ...
anaphase promoting complex subu.... AP4B1. 10717. AP4B1. adaptor related protein complex.... ARMC1. 55156. ARMC1. armadillo ... ATP synthase F1 subunit alpha [.... C10orf62. 414157. C10orf62. chromosome 10 open reading fram.... ...
Subunit interactions of the disease-related hexameric GlcNAc-1-phosphotransferase complex.. De Pace R, Velho RV, Encarnação M, ... RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway.. Asensio CS, Sirkis DW, ... Functions of the alpha, beta, and gamma subunits of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase.. Qian ... N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (UNIPROT: Q3T906). Organism: Homo sapiens. Download in FASTA ...
AP-2 complex subunit alpha-2. A. 630. Mus musculus. Mutation(s): 0 Gene Names: Ap2a2, Adtab. ... Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization.. Partlow, E.A., ... Instead, it is stimulated by endocytic pioneer proteins called muniscins, which do not enter vesicles. Muniscin-engaged AP2 is ... AP-2 complex subunit sigma. D [auth S]. 142. Mus musculus. Mutation(s): 0 Gene Names: Ap2s1, Ap17, Claps2. ...
Mih1 promotes downregulation of cell surface proteins in budding yeast by dephosphorylating a subunit of the retromer complex, ... 2002) The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late golgi membrane ... which resembles an alpha solenoid similar to well characterized vesicle coat proteins such as clathrin; Vps26 (standard name: ... 2000) The yeast Chs4 protein stimulates the trypsin-sensitive activity of chitin synthase 3 through an apparent protein-protein ...
EpsinR is an adaptor for the SNARE protein Vti1b. Mol. Biol. Cell 15, 5593-5602. ... Functional analysis of AP-2 alpha and mu2 subunits. Mol. Biol. Cell 17, 5298-5308. ... Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. The Journal of Cell ...
... and an repulsive subunit transporting acute 7-alpha-hydroxylase( CYP7B1). efforts in CYP7B1 can be such complex 5A( SPG5A), a ... shows bound in rich adaptor proteins. The numerous cells of Several damage in pathways get 12- and 15-HETE which have serum to ... protein mechanisms with protein mutations strongly dissipate PIP3 and be phagocytic inositol-1,4,5-trisphosphate in the subunit ... The motile others in the Intrinsic assembly contribute the Bcl-2 flotillin of variants that regulate autosomal protein-protein ...
... protein kinase A. HN - 2008(1998) BX - Protein Kinase A, RII alpha Subunit MH - Cyclic AMP-Dependent Protein Kinase RIIbeta ... The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the ... A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A ... HN - 2008 BX - Protein Kinase A, Catalytic Subunits MH - Cyclic AMP-Dependent Protein Kinase RIalpha Subunit UI - D054756 MN - ...
clathrin Adaptor Protein complex Large chain. Saccharomyces cerevisiae. Necessary For Fitness 25% APL2. ... Casein Kinase Alpha subunit. Saccharomyces cerevisiae. Anti-Longevity CKA2. 855418. CLA4. CLn Activity dependant. ... anaphase promoting complex subunit 5. Saccharomyces cerevisiae. Unclear APC5. 850792. APC9. anaphase promoting complex subunit ... clathrin Adaptor Protein complex Medium chain. Saccharomyces cerevisiae. Necessary For Fitness 50% APM1. ...
Furthermore, the neuron-specific coat proteins AP 180 and auxilin, as well as the alpha a1 and alpha c1-adaptins, were enriched ... Nerve terminal-derived coated vesicles contained AP-2 adaptor complexes, which is in agreement with their plasmalemmal origin. ... containing the membrane proteins synaptophysin, synaptotagmin, p29, synaptobrevin and the 116-kD subunit of the vacuolar proton ... Synaptic vesicle proteins and early endosomes in cultured hippocampal neurons: differential effects of Brefeldin A in axon and ...
... which are a family of cytoskeletal proteins. Polymorphism of ADD1 gene (encoding the alpha subunit, Entrez ID 118) has been ... soluble NSF attachment protein receptors) and SNAP (soluble NSF adaptor protein). They have been reported to play an important ... The igraph software package for complex network research. InterJournal. 2006. Complex Syst. 1695. ... Exocytosis proteins as novel targets for diabetes prevention and/or remediation? Am J Physiol Regul Integr Comp Physiol. 2017; ...
Palmitoylation and myristoylation represent the two most common protein lipid modifications, and dysregulation of protein ... Palmitoylation and myristoylation represent the two most common protein lipid modifications and dysregulation of protein ... The attachment of a lipid molecule to proteins endows distinct properties, which affect their hydrophobicity, structural ... Attachment of lipid molecule to proteins endows distinct properties which affect their hydrophobicity, structural stability, ...
1.839576 INESSENTIAL ARD1 subunit of the major N alpha-acetyltransferase; complexes with Nat1p, protein acetylation, peptide ... is part of two transcriptional adaptor HAT (histone acetyltransferase complexes, the 0.8 MD ADA complex and the 1.8 MD SAGA ... protein glycosylation, YML055W -1.488322 INESSENTIAL SPC2 subunit of signal peptidase complex, homologous to mammalian protein ... 2.154225 INESSENTIAL TPS3 115 kD regulatory subunit of trehalose-6-phosphate synthase phosphatase complex,alpha,alpha-trehalose ...
adaptor related protein complex 1 subunit beta 1. ISO. ClinVar Annotator: match by term: Autosomal recessive keratitis- ... collagen type VIII alpha 2 chain. ISO. ClinVar Annotator: match by term: Corneal dystrophy, Fuchs endothelial, 1. OMIM. ClinVar ... elongator acetyltransferase complex subunit 4. ISO. ClinVar Annotator: match by term: Aniridia 1. ClinVar. PMID:10737978 PMID: ... elongator acetyltransferase complex subunit 4. ISO. ClinVar Annotator: match by term: FOVEAL HYPOPLASIA 1 WITH OR WITHOUT ...
ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. He, G., Gupta, S., Yi, M., Michaely ... A region from the medium chain adaptor subunit (mu) recognizes leucine- and tyrosine-based sorting signals. Bremnes, T., ... Binding of clathrin AP-2 (adaptor complex) to an unidentified high affinity membrane receptor appears to be necessary for ... c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during ...
actin related protein 2/3 complex, subunit 5-like. Molecular. skeletal muscle. Human. ARPC5L. 2.0% Decrease Gene Expression ... adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. Molecular. skeletal muscle. Human. ... actin, alpha, cardiac muscle 1. Molecular. skeletal muscle. Human. ACTC1. 8.0% Increase Gene Expression Level. Add. ... ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9). Molecular. skeletal muscle. Human. ATP5G1. 4.0 ...

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