(1/12) Allograft reconstruction for bone sarcoma of the tibia in the growing child.

The outcome of tibial allograft reconstruction after resection of a tumour is inconsistent and has a high rate of failure. There are few reports on the use of tibial allografts in children with open growth plates. We performed 21 allograft reconstructions (16 osteoarticular, five intercalary) in 19 consecutive patients between seven and 17 years of age. Two had Ewing's sarcoma, one an adamantinoma and 16 osteosarcoma, one with multifocal disease. Five patients have died; the other 14 were free from disease at the time of follow-up. Six surviving patients (eight allograft reconstructions) continue to have good or excellent function at a mean of 59 months (14 to 132). One patient has poor function at 31 months. The other seven patients have a good or excellent function after additional procedures including exchange of the allograft and resurfacing or revision to an endoprosthesis at a mean of 101 months (43 to 198). The additional operations were performed at a mean of 47 months (20 to 84) after the first reconstruction. With the use of allograft reconstruction in growing children, joints and growth plates may be preserved, at least partially. Although our results remain inconsistent, tibial allograft reconstruction in selected patients may restore complete and durable function of the limb.  (+info)

(2/12) A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature.

Adamantinoma is known as a low-grade malignant biphasic tumor. Classic adamantinoma is in general characterized by admixture of both epithelial and osteofibrous components that are associated with various proportions and differentiation patterns. Osteofibrous dysplasia (OFD) is a self-limited benign fibro-osseous lesion of bone during infancy and childhood. OFD-like adamantinoma is characterized by predominance of osteofibrous tissues, in which small groups of epithelial cells are only detected by careful search or immunohistochemistry. There have been controversies as to the potential correlation among OFD, OFD-like adamantinoma and classic adamantinoma. We report an unusual case of adamantinoma arising in the tibia, with an extensive review of the literature. The present findings suggest a direct correlation between OFD-like adamantinoma and classic adamantinoma. At the age of 12 years, the tibial biopsy lesion was diagnosed as OFD. At the age of 23, the lesion became larger and more destructive on x-ray films. The biopsy lesion was diagnosed as classic adamantinoma. Wide excision was performed. The primary lesion was retrospectively diagnosed as OFD-like adamantinoma because of presence of keratin-positive epithelial cells within the stroma. At five years after surgery, the patient was free from recurrence or metastasis. The retrospective histological findings of OFD-like adamantinoma in the original biopsy and of a classic adamantinoma in all sections of the later resection specimen raised the possibility of an unusual progression of OFD-like adamantinoma to a classic adamantinoma. The present case and the literature review suggest that an OFD-like adamantinoma may be a precursor lesion of classic adamantinoma. Therefore, the possibility of progression of OFD-like adamantinoma to a classic adamantinoma should be kept in mind, particularly when the destructive changes are seen radiologically.  (+info)

(3/12) Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach?

Osteofibrous dysplasia is an unusual developmental condition of childhood, which almost exclusively affects the tibia. It is thought to follow a slowly progressive course and to stabilise after skeletal maturity. The possible link with adamantinoma is controversial and some authors believe that they are part of one histological process. We retrospectively reviewed 16 patients who were diagnosed as having osteofibrous dysplasia initially or on the final histological examination. Their management was diverse, depending on the severity of symptoms and the extent of the lesion. Definitive (extraperiosteal) surgery was localised "shark-bite" excision for small lesions in five patients. Extensive lesions were treated by segmental excision and fibular autograft in six patients, external fixation and bone transport in four and proximal tibial replacement in one. One patient who had a fibular autograft required further excision and bone transport for recurrence. Six initially underwent curettage and all had recurrence. There were no recurrences after localised extraperiosteal excision or bone transport. There were three confirmed cases of adamantinoma. The relevant literature is reviewed. We recommend extraperiosteal excision in all cases of osteofibrous dysplasia, with segmental excision and reconstruction in more extensive lesions.  (+info)

(4/12) Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report.

We treated a case with left tibial adamantinoma by use of a contralateral fibular osteoadiposal flap. The donor site of conventional fibular osteocutaneous flap must be covered with a skin graft because if we close the donor skin defect directly, compartment syndrome might occur. We were able to close the donor skin defect because this combined type flap included only a small monitoring skin paddle. We present herein the utility of the osteoadiposal flap and show the value of a skin-sparing approach with a minimal aesthetic defect.  (+info)

(5/12) Preliminary report of expression of bax in oral cavity pathologies.

Bax is considered one of major effectors of apoptosis--programmed cell death. Immunohistochemical analysis of in vitro patterns of bax expression was mostly investigated in mammalian cell lines and tissues. The present study is the first in vivo molecular analysis of bax expression in oral cavity pathologies. The study population consisted of 45 patients with hyperplasia, neoplasm in situ malignancy, and carcinoma. Biopsies were taken from incision line, tumour section, and healthy tissue. bax expression was investigated depending on the site of biopsy material sampling and final histopathology result. No statistically significant difference was demonstrated in bax expression between four hyperplasia subgroups. However, statistically significant differences in bax expression were found between the three basic study groups (P = 0.001). Statistically significant differences in bax expression were demonstrated depending on tissue collection site (P = 0.0002). We conclude that differences in bax expression may play a role in the pathogenesis of neoplastic disease.  (+info)

(6/12) Adamantinoma of the tibia with late skeletal metastasis: an unusual presentation.

Adamantinoma is a rare tumour of long bones that occurs most commonly in the tibia. Its pathogenesis is unknown. It is locally aggressive and recurrences are common after resection. Metastases have been reported in 10% to 20% of cases, most commonly in the lungs and rarely in the lymph nodes. We report a patient who developed a skeletal metastasis four years after resection of the primary tumour. There was no evidence of recurrence at the primary site or of secondary deposits in the lungs.  (+info)

(7/12) Treatment of osteofibrous dysplasia and associated lesions.

PURPOSE: To report long term treatment outcomes of osteofibrous dysplasia and association with adamantinoma. PATIENTS AND METHODS: From January 1984 to July 2001, 14 patients with osteofibrous dysplasia were followed for an average of 108 months (78 to 260 months). Our patient group consisted of 6 men and 8 women, with a mean age of 13.9 years (2 to 65 years). We reviewed the clinical and pathological features of all 14 patients. RESULTS: Thirteen patients had a lesion in the tibia, while one patient had lesions in both the tibia and the fibula. Initial treatments were observation after biopsy (6 patients), curettage with or without a bone graft (3 patients), resection followed by a free vascularized fibular bone graft (4 patients), or resection and regeneration with the Ilizarov external fixation (1 patient). Curettage was performed on 6 patients due to recurrence or progression after the initial treatment. Among these patients, one was diagnosed with AD from the biopsy of the recurrent lesion. This patient was further treated by segmental resection and pasteurization. After the initial pathology slides of the 13 patients were reviewed with immunohistochemical cytokeratin staining, one patient diagnosis was changed from osteofibrous dysplasia to osteofibrous dysplasia-like adamantinoma. CONCLUSION: Some patients with osteofibrous dysplasia require close observation because of the high association risk between osteofibrous dysplasia and adamantinoma, Immunohistochemical staining may be helpful in differentiating these two diagnoses.  (+info)

(8/12) Analysis of stromal cells in osteofibrous dysplasia and adamantinoma of long bones.

 (+info)

*  Ameloblastoma
This type of odontogenic neoplasm was designated as an adamantinoma in 1885 by the French physician Louis-Charles Malassez. It ...
*  Adamantinoma
Benign osteofibrous dysplasia may be a precursor of adamantinoma or a regressive phase of adamantinoma. Histologically, islands ... "A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the ... Adamantinoma (from the Greek word adamantinos, meaning "very hard") is a rare bone cancer, making up less than 1% of all bone ... "Adamantinoma: Overview - eMedicine". Archived from the original on 25 December 2008. Retrieved 2009-01-04. Fischer B. Uber ein ...
*  Osteofibrous dysplasia
"A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the ... Several authors have related this non-neoplastic lesion to adamantinoma - a tumor involving subcutaneous long bones - stating ...
*  List of MeSH codes (C05)
... adamantinoma MeSH C05.116.231.343 --- femoral neoplasms MeSH C05.116.231.754 --- skull neoplasms MeSH C05.116.231.754.450 --- ...
*  List of MeSH codes (C04)
... adamantinoma MeSH C04.588.149.276 --- femoral neoplasms MeSH C04.588.149.721 --- skull neoplasms MeSH C04.588.149.721.450 --- ...
*  Adamantine
... a bulky hydrocarbon Adamantinoma, a form of bone cancer. ...
*  Index of trauma & orthopaedics articles
Adamantinoma - Adhesive capsulitis of shoulder - Advanced trauma life support - Ainhum - Akin osteotomy - Albers-Schonberg ...
*  International Classification of Diseases for Oncology
NOS Adamantinoma, NOS (except of long bones M9261/3) M9310/3 Ameloblastoma, malignant Adamantinoma, NOS (except of long bones ... malignant M9260/3 Ewing's sarcoma/tumor M9261/3 Adamantinoma of long bones M9262/0 Ossifying fibroma Fibro-osteoma Osteofibroma ...
Gentaur Molecular :US Biomax \ Adamantinoma and hamartoma tissue array, 40 cases 80 cores \ MC804  Gentaur Molecular :US Biomax \ Adamantinoma and hamartoma tissue array, 40 cases 80 cores \ MC804
Adamantinoma and hamartoma tissue array, 40 cases_80 cores \ MC804 for more molecular products just contact us ... Adamantinoma and hamartoma tissue microarray, containing 22 cases of bone adamantinoma, 18 hamartoma of kidney and liver, ... We have also other products like : Adamantinoma and hamartoma tissue array, 40 cases_80 cores. Related products : Adamantinoma ... Index / US Biomax / Adamantinoma and hamartoma tissue array, 40 cases_80 cores / Product Detail : MC804 Adamantinoma and ...
more infohttp://www.antibody-antibodies.com/product_det.php?id=1004785&supplier=search&name=Adamantinoma%20and%20hamartoma%20tissue%20array,%2040%20cases_80%20cores
Diagnostic Radiology/Musculoskeletal Imaging/Tumors Basic/Adamantinoma - Wikibooks, open books for an open world  Diagnostic Radiology/Musculoskeletal Imaging/Tumors Basic/Adamantinoma - Wikibooks, open books for an open world
Adamantinoma of Long Bone (extragnathic adamantinoma): Adamantinoma is a rare primary low-grade malignant tumor of bone that is ... Adamantinoma of the long bone is not related to adamantinoma or ameloblastoma of the mandible and maxilla, which is derived ... state that there is an entity known as osteofibrous dyplasia-like adamantinoma (differentiated adamantinoma) that may be a ... Adamantinoma usually presents as an intraosseous, intracortical stage I-A sarcoma.. This low-grade, slowly-growing malignancy ...
more infohttps://en.m.wikibooks.org/wiki/Diagnostic_Radiology/Musculoskeletal_Imaging/Tumors_Basic/Adamantinoma
Ameloblastoma - Wikipedia  Ameloblastoma - Wikipedia
This type of odontogenic neoplasm was designated as an adamantinoma in 1885 by the French physician Louis-Charles Malassez. It ...
more infohttps://en.wikipedia.org/wiki/Ameloblastoma
Disseminating Adamantinoma of the Tibia  Disseminating Adamantinoma of the Tibia
... Albert N. Van Geel,1,2 Hans M. Hazelbag,3 Rob Slingerland,4 and Margit I. Vermeulen1 ... All types of adamantinoma should be treated by complete en bloc resection. For patients with metastatic spread to the lungs, ... This report describes a patient with a primary long bone adamantinoma. The lesion was initially wrongly diagnosed as fibrous ... the tumour had progressed from an osteofibrous dysplasia-like to a full-blown classic adamantinoma, with metastatic potential ...
more infohttps://www.hindawi.com/journals/sarcoma/1997/727823/abs/
Adamantinoma - Orthopaedic Web Links  Adamantinoma - Orthopaedic Web Links
Adamantinoma of Long Bone (extragnathic adamantinoma): Adamantinoma is a rare primary low-grade malignant tumor of bone that is ... Adamantinoma of Long Bone (extragnathic adamantinoma): Adamantinoma is a rare primary low-grade malignant tumor of bone that is ... Adamantinoma at Orthonet Location: http://www.orthonet.on.ca/adamantinoma/ Adamantinoma - 1o bone tumor with predilection for ... Adamantinoma of the long bone is not related to adamantinoma or ameloblastoma of the mandible and maxilla, which is derived ...
more infohttps://www.orthopaedicweblinks.com/OCOSH_Classification/Orthopaedic_Oncology/Connective_and_Soft_Tissue_Neoplasms/Bone_Neoplasms/Adamantinoma/index.html
Adamantinoma | definition of adamantinoma by Medical dictionary  Adamantinoma | definition of adamantinoma by Medical dictionary
... adamantinoma explanation free. What is adamantinoma? Meaning of adamantinoma medical term. What does adamantinoma mean? ... Looking for online definition of adamantinoma in the Medical Dictionary? ... adamantinoma. /ad·a·man·ti·no·ma/ (ad″ah-man″tĭ-no´mah) ameloblastoma.. adamantinoma, adamantoblastoma. See ameloblastoma. ... Our understanding of the relationship among classic adamantinoma, differentiated adamantinoma (osteofibrous dysplasia-like ...
more infohttps://medical-dictionary.thefreedictionary.com/adamantinoma
Adamantoma | definition of adamantoma by Medical dictionary  Adamantoma | definition of adamantoma by Medical dictionary
... adamantoma explanation free. What is adamantoma? Meaning of adamantoma medical term. What does adamantoma mean? ... Looking for online definition of adamantoma in the Medical Dictionary? ... adamantoma. adamantoma. /ad·a·man·to·ma/ (ad″ah-man-to´mah) ameloblastoma.. adamantoblastoma, adamantoma. see ameloblastoma. ... Adamantoma , definition of adamantoma by Medical dictionary https://medical-dictionary.thefreedictionary.com/adamantoma ...
more infohttps://medical-dictionary.thefreedictionary.com/adamantoma
Adamantinoma - Wikipedia  Adamantinoma - Wikipedia
Benign osteofibrous dysplasia may be a precursor of adamantinoma or a regressive phase of adamantinoma. Histologically, islands ... "A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the ... Adamantinoma (from the Greek word adamantinos, meaning "very hard") is a rare bone cancer, making up less than 1% of all bone ... "Adamantinoma: Overview - eMedicine". Archived from the original on 25 December 2008. Retrieved 2009-01-04. Fischer B. Uber ein ...
more infohttps://en.wikipedia.org/wiki/Adamantinoma
Medicowesome: Adamantinoma  Medicowesome: Adamantinoma
Today's topic is - ADAMANTINOMA ! (and no it's not what would only happen to Wolverine! Haha see what I did there ?! ) ...
more infohttps://www.medicowesome.com/2016/12/adamantinoma.html
Adamantinoma of Long Bones | Musculoskeletal Key  Adamantinoma of Long Bones | Musculoskeletal Key
The name adamantinoma was given to this tumor because of its histologic resemblance to the more common adamantinoma ( ... Figure 24.2. Adamantinoma involving the tibia and fibula in a 19-year-old woman. A: Extensive involvement of the cortex of the ... Some cases of adamantinoma have also been reported in short tubular bones, but the diagnoses in these cases have to be ... Adamantinoma of long bones is a peculiar neoplasm that, on the basis of radiographic and pathologic features, arises within the ...
more infohttps://musculoskeletalkey.com/adamantinoma-of-long-bones/
Tumor Library - Case Detail - Adamantinoma - Tibia - Photomicrograph  Tumor Library - Case Detail - Adamantinoma - Tibia - Photomicrograph
Tumor Library - Cancer Oncology - Welcome to the James O. Johnston Orthopaedic Oncology Tumor Library. This site is intended to offer the oppotunity to cancer research of Orthopaedic Oncology diagnosis slides and imagery from Dr. Johnson s personal library.
more infohttp://tumorlibrary.com/case/detail.jsp?image_id=5348
Adamantinoma-like Ewings sarcoma: Genomic confirmation, phenotypic drift<...  Adamantinoma-like Ewing's sarcoma: Genomic confirmation, phenotypic drift<...
Adamantinoma-like Ewing's sarcoma. Genomic confirmation, phenotypic drift. Julia A. Bridge, Mary E. Fidler, James R. Neff, ... Adamantinoma-like Ewing's sarcoma: Genomic confirmation, phenotypic drift. American Journal of Surgical Pathology. 1999 Feb 1; ... Adamantinoma-like Ewing's sarcoma : Genomic confirmation, phenotypic drift. / Bridge, Julia A.; Fidler, Mary E.; Neff, James R ... keywords = "Adamantinoma, EWS/FLI1, Ewing's sarcoma, Karyotype, RT/PCR",. author = "Bridge, {Julia A.} and Fidler, {Mary E.} ...
more infohttps://nebraska.pure.elsevier.com/en/publications/adamantinoma-like-ewings-sarcoma-genomic-confirmation-phenotypic-
Primary pulmonary synovial sarcoma requiring differentiation from pulmonary metastasis of tibial adamantinoma: a case report |...  Primary pulmonary synovial sarcoma requiring differentiation from pulmonary metastasis of tibial adamantinoma: a case report |...
The patient was well without evidence of recurrence or metastasis of the PPSS or adamantinoma at the 30-month and 15-year ... The solitary pulmonary nodule in this case was indistinguishable from pulmonary metastases of the adamantinoma based on ... We considered the possibility of pulmonary metastasis from the adamantinoma and performed fluoroscopy-assisted thoracoscopic ... To our knowledge, this is the first report of PPSS complicated by adamantinoma. ...
more infohttps://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-7-736/figures/2
July-August 1972 - Volume 86 - Issue  : Clinical Orthopaedics and Related Research®  July-August 1972 - Volume 86 - Issue : Clinical Orthopaedics and Related Research®
So-called "Adamantinoma of Long Bone". Zand, Abbas; Chambers, George H.; Street, Dana M. ...
more infohttps://journals.lww.com/clinorthop/toc/1972/07000
The Radiology Assistant : Bone tumor  A-G  The Radiology Assistant : Bone tumor A-G
Adamantinoma (4). On the left a radiograph and CT-image of another typical adamantinoma. CT was performed prior to biopsy. ... Adamantinoma (3). Adamantinoma of the tibia in another patient.. There is an ovoid osteolytic lesion within the anterior ... ABC versus Adamantinoma. Notice resemblance between intracortical ABC in tibia (left) and Adamantinoma (right). ... Adamantinoma (2). Young patient with a lobulated lytic lesion within the anterior cortical bone of the proximal tibia. There is ...
more infohttp://radiologyassistant.nl/en/p4bc9b15f76a78/bone-tumor-a-g.html
Bone Sarcomas  Bone Sarcomas
Adamantinoma. Adamantinoma of the long bones, or extragnathic adamantinoma, is an extremely rare, slow growing, low-grade ...
more infohttps://www.reininsarcoma.org/what-is-sarcoma-2/bone-sarcomas/
Bone Sarcoma Types | SARC  Bone Sarcoma Types | SARC
Adamantinoma. This is a very rare tumor of cells that are associated with bone formation in a process that may be similar to ... Adamantinoma nearly always affects the tibia, and is treated with surgery. Rare cases can travel elsewhere in the body, at ...
more infohttps://sarctrials.org/bone-sarcoma
Kemiğin tümöre benzer lezyonlari (fazlası için www.tipfakultesi.org ) - English  Kemiğin tümöre benzer lezyonlari (fazlası için www.tipfakultesi.org ) - English
24.89 Adamantinoma of tibia. Lack of cohesiveness of tumor cells in some of the islands results in a pseudovascular appearance ... 24.91 Immunoreactivity for keratin in the tumor cells of adamantinoma of tibia. ...
more infohttps://www.slideshare.net/mbolmez/kemiin-tmre-benzer-lezyonlari-1-saat
Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors -...  Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors -...
Adamantinoma. Rhabdoid Tumor. Paraganglioma. Carotid Body Tumor. Choroid Plexus Neoplasms. Pinealoma. Optic Nerve Glioma. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01076530
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders - Full Text View - ClinicalTrials.gov  An Investigation of Pituitary Tumors and Related Hypothalmic Disorders - Full Text View - ClinicalTrials.gov
Adamantinoma. Endocrine System Diseases. Hypothalamic Diseases. Brain Diseases. Central Nervous System Diseases. Nervous System ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00001595?term=pituitary+tumor&rank=5
Bone & Soft Tissue Cancers - Cancers We Treat  - Wilmot Cancer Institute - University of Rochester Medical Center  Bone & Soft Tissue Cancers - Cancers We Treat - Wilmot Cancer Institute - University of Rochester Medical Center
Tumors can originate in any type of bone cells, and they can be either benign (non-cancerous) or malignant (cancer). Bone cancers can also be:. Primary: These are cancers that originate in the bone.. Metastatic: These are cancers that start in other parts of the body - such as the lung, breast, or prostate - and spread to the bone. Metastatic cancers in the bone are more common than primary bone cancers.. ...
more infohttps://www.urmc.rochester.edu/cancer-institute/cancers/bone-soft-tissue.aspx
Bone Tumors Ger | Metastasis | Bone  Bone Tumors Ger | Metastasis | Bone
Characteristic Locations • • • • Adamantinoma • • Simple bone cyst Proximal humerus Chondroblastoma Epiphyses Giant Cell tumor ... clivus Osteoblastoma Spine.• Simple bone cyst • • • • • Chondroblastoma Epiphyses Giant Cell tumor Epiphyses Adamantinoma Tibia ... Simple bone cyst Proximal humerus Chondroblastoma Epiphyses Giant Cell tumor Epiphyses Adamantinoma Tibia Chordoma Sacrum. ... Simple bone cyst Proximal humerus Chondroblastoma Epiphyses Giant Cell tumor Epiphyses Adamantinoma Tibia • Chordoma • ...
more infohttps://www.scribd.com/presentation/148977728/Bone-Tumors-Ger
Atlas of Musculoskeletal Tumors and Tumorlike Lesions | SpringerLink  Atlas of Musculoskeletal Tumors and Tumorlike Lesions | SpringerLink
This book reflects the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment of musculoskeletal tumor and tumorlike lesions. It presents a wide range of lesions from a
more infohttps://link.springer.com/book/10.1007/978-3-319-01748-8
Oncology - UCLA Orthopaedic Surgery, Los Angeles & Santa Monica, CA  Oncology - UCLA Orthopaedic Surgery, Los Angeles & Santa Monica, CA
Musculoskeletal Oncology Service manages all bone and soft-tissue tumors, benign and malignant, primary, recurrent and metastatic as well as tumor-like conditions of bone.
more infohttps://www.uclahealth.org/ortho/body.cfm?id=39&iirf_redirect=1
  • MRI findings in adamantinoma are non-specific, but can help demonstrate intraosseous and extrasseous involvement. (wikibooks.org)
  • Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy. (wikipedia.org)