(1/428) Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility.

Rabbit cytochromes P-450 (P-450) 2B4 and 2B5 differ by only 12 amino acid residues yet they exhibit unique steroid hydroxylation profiles. Previous studies have led to the identification of active site residues that are determinants of these specificities. In this study, mechanism-based inactivators were identified that discriminate between the closely related 2B4 and 2B5 enzymes. A previously characterized inhibitor, 2-ethynylnaphthalene (2EN), was found to be selective for 2B4 inactivation. As inhibitor metabolism and the partition ratio affect susceptibility, molecular dynamics simulations were performed to assess the stability of the productive binding orientation of 2EN within 2B4 and 2B5 three-dimensional models. Although 2EN was stable within the 2B4 model, it exhibited substantial movement away from the heme moiety in the 2B5 model. However, heterologously expressed 2B5 was found to catalyze the oxidation of 2EN to the stable product 2-naphthylacetic acid. Thus, the increased mobility of 2EN may result in reduced susceptibility of 2B5 by increasing the probability that the reactive ketene intermediate hydrolyzes with water instead of reacting with active site residues. Another compound, 1-adamantyl propargyl ether (1APE), selectively inactivated 2B5. The structural basis for 2EN and 1APE susceptibility was assessed using active site mutants. Interconversion of 2EN susceptibility was observed for 2B4 or 2B5 mutants containing a single alteration at residue 363. Single substitutions in 2B4 also conferred susceptibility to 1APE; however, multiple alterations were required to reduce the susceptibility of 2B5. These alterations may influence inhibitor susceptibility by affecting the stability of the productive binding orientation.  (+info)

(2/428) Guest exchange in an encapsulation complex: a supramolecular substitution reaction.

Encapsulation complexes are reversibly formed assemblies in which small molecule guests are completely surrounded by large molecule hosts. The assemblies are held together by weak intermolecular forces and are dynamic: they form and dissipate on time scales ranging from milliseconds to days-long enough for many interactions, even reactions, to take place within them. Little information is available on the exchange process, how guests get in and out of these complexes. Here we report that these events can be slow enough for conventional kinetic studies, and reactive intermediates can be detected. Guest exchange has much in common with familiar chemical substitution reactions, but differs in some respects: no covalent bonds are made or broken, the substrate is an assembly rather than a single molecule, and at least four molecules are involved in multiple rate-determining steps.  (+info)

(3/428) Eukaliuric diuresis and natriuresis in response to the KATP channel blocker U37883A: micropuncture studies on the tubular site of action.

1. Systemic application of U37883A, a blocker of ATP sensitive potassium (KATP) channels, elicits diuresis and natriuresis without significantly altering urinary potassium excretion. 2. To elucidate tubular sites of action upstream to the distal nephron, micropuncture experiments were performed in nephrons with superficial glomeruli of anaesthetized Munich-Wistar-Fromter rats during systemic application of U37883A (1, 5 or 15 mg kg-1 i.v.). 3. The observed eukaliuric diuresis and natriuresis in response to U37883A at 15 mg kg-1 was accompanied by an increase in early distal tubular flow rate (VED) from 10 - 18 nl min(-1) reflecting a reduction in fractional reabsorption of fluid up to this site (FR-fluid) of 13%. The latter proposed an effect on water-permeable segments such as the proximal tubule which could fully account for the observed reduction in fractional reabsorption of Na+ up to the early distal tubule (FR-Na+) of 8% and the increase in early distal tubular Na+ concentration ([Na+]ED) from 35 - 51 mM whereas [K+]ED was left unaltered. 4. In comparison, furosemide (3 mg kg-1 i.v.), which acts in the water-impermeable thick ascending limb, elicited diuresis, natriuresis and kaliuresis which were associated with a fall in FR-Na+ of 10% with no change in FR-fluid, and a rise in [Na+]ED from 42 - 117 mM and [K+]ED from 1.2 - 5.7 mM with no change in VED. 5. Direct late proximal tubular fluid collections confirmed a significant inhibition of fluid reabsorption in proximal convoluted tubule in response to systemic application of U37883A. 6. These findings suggest that the diuretic and natriuretic effect upstream to the distal tubule in response to systemic application of U37883A involves actions on water-permeable segments such as the proximal convoluted tubule.  (+info)

(4/428) Analysis of vasoconstrictor responses to histamine in the hindlimb vascular bed of the rabbit.

Hemodynamic responses to histamine were investigated in the anesthetized rabbit. Intravenous injections of histamine induced dose-dependent decreases in systemic arterial pressure that were blocked by the H(1)-receptor antagonist pyrilamine but not the H(2) antagonist cimetidine. Injections of histamine and the H(1) agonist 6-[2-(4-imidazolyl)ethylamine]-N-(4-trifuormethylphenyl)-heptan ecardo xamide dimaleate (HTMT) into the hindlimb perfusion circuit increased hindlimb perfusion pressure, whereas the H(2) agonist dimaprit decreased perfusion pressure and the H(3)-receptor agonist R-(-)-alpha-methylhistamine did not alter perfusion pressure. Pyrilamine reduced hindlimb vasoconstrictor responses to histamine and HTMT but did not alter vasodilator responses to dimaprit. Cimetidine reduced the response to dimaprit but did not alter vasoconstrictor responses to histamine or HTMT. The H(3)-receptor antagonist thioperamide was without effect on responses to the histamine agonists. These data suggest the presence of H(1) and H(2) receptors and that histamine for the most part acts by stimulating H(1) receptors to produce vasoconstriction in the hindlimb vascular bed of the rabbit. Responses to histamine, HTMT, and norepinephrine were significantly enhanced by a nitric oxide synthase inhibitor at a time when vasodilator responses to dimaprit were unaltered and responses to acetylcholine were significantly reduced. Responses to histamine and the H(1) and H(2) agonists were not affected by the cyclooxygenase inhibitor meclofenamate or by ATP-sensitive K(+) channel, alpha-adrenergic, or angiotensin AT(1) receptor antagonists. The present data suggest that H(1) receptors mediate both systemic vasodepressor and hindlimb vasoconstrictor responses to histamine.  (+info)

(5/428) Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A.

1. A human aorta cDNA library was screened at low stringency with a rat pancreatic Kir6.1 cDNA probe and a homologue of Kir6.1 (hKir6.1) was isolated and sequenced. 2. Metabolic poisoning of Xenopus laevis oocytes with sodium azide and application of the K+ channel opener drug diazoxide induced K+ channel currents in oocytes co-injected with cRNA for hKir6.1 and hamster sulphonylurea receptor (SUR1), but not in oocytes injected with water or cRNA for hKir6.1 or SUR1 alone. 3. K+ channel currents due to hKir6.1+SUR1 or mouse Kir6.2+SUR1 were strongly inhibited by 1 microM glibenclamide. K+-current carried by hKir6.1+SUR1 was inhibited by the putative vascular-selective KATP channel inhibitor U37883A (IC50 32 microM) whereas current carried by Kir6.2+SUR1 or Shaker K+ channels was unaffected. 4. The data support the hypothesis that hKir6.1 is a component of the vascular KATP channel, although the lower sensitivity of hKir6.1+SUR1 to U37883A compared with native vascular tissues suggests the need for another factor or subunit. Furthermore, the data suggest that pharmacology of KATP channels can be determined by the pore-forming subunit as well as the sulphonylurea receptor and point to a molecular basis for the pharmacological distinction between vascular and pancreatic/cardiac KATP channels.  (+info)

(6/428) Inhibition of vascular K(ATP) channels by U-37883A: a comparison with cardiac and skeletal muscle.

1 The aim of this study was to investigate the selectivity of the ATP-sensitive potassium (K(ATP)) channel inhibitor U-37883A (4-morpholinecarboximidine-N-1-adamantyl-N'-1-cyclohexyl). Membrane currents through K(ATP) channels were recorded in single muscle cells enzymatically isolated from rat mesenteric artery, cardiac ventricle and skeletal muscle (flexor digitorum brevis). K(ATP) currents were induced either by cell dialysis with 0.1 mM ATP and 0.1 mM ADP, or by application of synthetic potassium channel openers (levcromakalim or pinacidil). 2 U-37883A inhibited K(ATP) currents in smooth muscle cells from rat mesenteric artery. Half inhibition of 10 microM levcromakalim-induced currents occurred at a concentration of 3.5 microM. 3 Relaxations of rat mesenteric vessels caused by levcromakalim were reversed by U-37883A. 1 microM levcromakalim-induced relaxations were inhibited at a similar concentration of U-37883A (half inhibition, 1.1 microM) to levcromakalim-induced KATP currents. 4 K(ATP) currents activated by 100 microM pinacidil were also studied in single myocytes from rat mesenteric artery, skeletal muscle and cardiac ventricle. 10 microM U-37883A substantially inhibited K(ATP) currents in vascular cells, but had little effect in skeletal or cardiac myocytes. Higher concentrations of U-37883A (100 microM) caused a modest decrease in K(ATP) currents in skeletal and cardiac muscle. The sulphonylurea K(ATP) channel antagonist glibenclamide (10 microM) abolished currents in all muscle types. 5 The effect of U-37883A on vascular inward rectifier (KIR) and voltage-dependent potassium (KV) currents was also examined. While 10 microM U-37883A had little effect on these currents, some inhibition was apparent at higher concentrations (100 microM) of the compound. 6 We conclude that U-37883A inhibits K(ATP) channels in arterial smooth muscle more effectively than in cardiac and skeletal muscle. Furthermore, this compound is selective for K(ATP) channels over KV and KIR channels in smooth muscle cells.  (+info)

(7/428) Early increases in renal kallikrein secretion on administration of potassium or ATP-sensitive potassium channel blockers in rats.

1 This study aimed to examine whether administration of potassium or ATP-sensitive potassium channel (KATP channel) blockers caused early increases in renal kallikrein (KK) secretion. To clarify this mechanism, the effect on renal KK secretion of a KATP channel blocker was compared with the effect resulting from use of an osmotic diuretic or volume load. Furthermore, the effect on potassium-induced increases in renal KK secretion by an additional treatment using a KATP channel blocker was examined. Lastly, the effect of a KATP channel blocker on renal KK secretion was also examined in superfused slices of kidney cortex. 2 Intravenous infusion of potassium augmented renal KK secretion within 30 min while urine volume increased gradually in both the potassium loading and control groups. 3 Administration of the KATP channel blocker, 4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexylhydr ochloride (PNU-37883A) or glibenclamide, caused a dose-dependent increase in renal KK secretion. 4 The concentration of KK in urine was higher in the PNU-37883A group as compared to the osmotic-diuretic or volume-load group. 5 PNU-37883A had no additive effect on the potassium-induced increase in renal KK secretion. 6 Renal KK secretion increased in slices of kidney cortex incubated with PNU-37883A within 10 min of superfusion. 7 In conclusion, administration of both potassium and KATP channel blockers induced early increases in renal KK secretion in the absence of the washout phenomenon. Potassium loading may have increased renal KK secretion through the same mechanism as the KATP channel blocker.  (+info)

(8/428) Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro.

The tyrphostin AG957 (NSC 654705) inhibits p210bcr/abl, the transforming kinase responsible for most cases of chronic myelogenous leukemia (CML). The present studies were performed to determine the fate of AG957-treated cells and assess the selectivity of AG957 for CML myeloid progenitors. When K562 cells (derived from a patient with blast crisis CML) were treated with AG957, dose- and time-dependent p210bc/abl down-regulation was followed by mitochondrial release of cytochrome c, activation of caspase-9 and caspase-3, and apoptotic morphological changes. These apoptotic changes were inhibited by transfection with cDNA encoding dominant negative caspase-9 but not dominant-negative FADD or blocking anti-Fas antibodies. In additional experiments, a 24-h AG957 exposure caused dose-dependent inhibition of K562 colony formation in soft agar. To extend these studies to clinical samples of CML, peripheral blood mononuclear cells from 10 chronic phase CML patients and normal controls were assayed for the growth of hematopoietic colonies in vitro in the presence of increasing concentrations of AG957. These assays demonstrated selectivity of AG957 for CML progenitors, with median IC50s (CML versus normal) of 7.3 versus >20 microM AG957 in granulocyte colony-forming cells (P < 0.001), 5.3 versus >20 microM in granulocyte/macrophage colony-forming cells (P < 0.05), and 15.5 versus > 20 microM in erythroid colony-forming cells (P > 0.05). The adamantyl ester of AG957 (NSC 680410) down-regulated p210bcr/abl in K562 cells and inhibited granulocyte colony formation in CML specimens at lower concentrations without enhanced toxicity in normal progenitors. These observations not only demonstrate that AG957-induced p210bcr/abl down-regulation is followed by activation of the cytochrome c/Apaf-1/caspase-9 pathway but also indicate that this class of kinase inhibitor exhibits selectivity worthy of further evaluation.  (+info)

*  Diamondoid
... s also known as nanodiamonds or condensed adamantanes may include one or more cages (adamantane, diamantane, ... Examples include: Adamantane (C10H16) Iceane (C12H18) BC-8 (C14H20) Diamantane (C14H20) also diadamantane, two face-fused cages ... Adamantane derivatives have been proposed as a functionalizing molecule for enhancing electron-tunneling-based DNA sequencing ... García, J. C.; Justo, J. F.; Machado, W. V. M.; Assali, L. V. C. (2009). "Functionalized adamantane: building blocks for ...
*  Adamantane
... adamantane should be called tricyclo[3.3.1.13,7]decane. However, IUPAC recommends using the name "adamantane". The adamantane ... adamantane slowly sublimes even at room temperature. Adamantane can be distilled with water vapor. The adamantane molecule ... Today, adamantane is an affordable chemical compound with a cost of about $1 a gram. All the above methods yield adamantane as ... The adamantane cation can be produced by reacting 1-fluoro-adamantane with SbF5 and it has high stability compared with other ...
*  Phosphatrioxa-adamantane
... is an organophosphorus compound that is used as a precursor to bulky phosphine ligands. Abbreviated ... Paul G. Pringle, Martin B. Smith "Phosphatrioxa-adamantane Ligands" in Phosphorus(III) Ligands in Homogeneous Catalysis: Design ...
*  Dicyclopentadiene
"Adamantane". Organic Syntheses. CS1 maint: Multiple names: authors list (link) ; Collective Volume, 5, p. 16 Li, Xiaofang; Hou ... endo-tetrahydrodicyclopentadiene which on reaction with aluminium chloride at elevated temperature rearranges to adamantane. ...
*  Bromantane
Other adamantane antivirals subsequently followed, such as rimantadine (1-(1-aminoethyl)adamantane) and adapromine (1-(1- ... Bromantane is an adamantane derivative. It is also known as adamantylbromphenylamine, from which its name was derived. In the ... Bromantane, sold under the brand name Ladasten, is an atypical psychostimulant and anxiolytic drug of the adamantane family ... These findings may also extend to the other adamantanes such as adapromine, rimantadine, and bromantane, and might potentially ...
*  List of dopaminergic drugs
Adamantanes: Amantadine • Memantine • Rimantadine Aminotetralins: 7-OH-DPAT • 8-OH-PBZI • Rotigotine • UH-232 Benzazepines: 6- ...
*  Adapromine
These findings might also extend to the other adamantanes such as adapromine, rimantadine, and bromantane and could explain the ... Morozov, I. S.; Ivanova, I. A.; Lukicheva, T. A. (2001). "Actoprotector and Adaptogen Properties of Adamantane Derivatives (A ... Tromantadine Spasov, A. A.; Khamidova, T. V.; Bugaeva, L. I.; Morozov, I. S. (2000). "Adamantane derivatives: Pharmacological ... Adapromine is an antiviral drug of the adamantane group related to amantadine (1-aminoadamantane), rimantadine (1-(1-aminoethyl ...
*  Hexamethylenetetramine
It has a cage-like structure similar to adamantane. It is useful in the synthesis of other chemical compounds, e.g., plastics, ... Garcia, J. C.; Justo, J. F.; Machado, W. V. M.; Assali, L. V. C. (2009). "Functionalized adamantane: building blocks for ... The molecule has a symmetric tetrahedral cage-like structure, similar to adamantane, whose four "corners" are nitrogen atoms ...
*  Iceane
Adamantane Twistane Propellane Hexanitrohexaazaisowurtzitane Fieser, L. F. (1965). "Extensions in the use of plastic ...
*  Propellane
Highly reactive 1,3-dehydro derivative of adamantane". J. Am. Chem. Soc. 91 (16): 4593-4593. doi:10.1021/ja01044a072. ... This compound is formally derived from adamantane by removing two hydrogens and adding an internal bond. It can be viewed as [ ...
*  Phosphorus trioxide
This colorless solid is structurally related to adamantane. It is formally the anhydride of phosphorous acid, H3PO3, but cannot ...
*  1,3-Dehydroadamantane
Highly reactive 1,3-dehydro derivative of adamantane". J. Am. Chem. Soc. 91 (16): 4593-4593. doi:10.1021/ja01044a072. Matsuoka ... which can be obtained from adamantane by removal of two hydrogen atoms to create an internal bond. It is a polycyclic ...
*  Covalent organic framework
"Functionalized adamantane: building blocks for nanostructure self-assembly". Phys. Rev. B. 80: 125421. arXiv:1204.2884 . ...
*  Diamantane
Adamantane was the first, and "Congressane", as diamantane came to be known, was only the second member of an entire family of ... Olah, G. A; Ramaiah, P.; Rao, C. B.; Sandford, G.; Golam, R.; Trivedi, N. J.; Olah, J. A. (1993). "Nitration of adamantane and ... Diamantane then became as readily available as adamantane and its chemistry could be studied more easily. Diamantane can be ... Gordadze, G. N.; Giruts, M. V. (2008). "Synthesis of adamantane and diamantane hydrocarbons by high-temperature cracking of ...
*  Ruthenium tetroxide
For example, it will oxidize adamantane to 1-adamantanol. Because it is such an aggressive oxidant, reaction conditions must be ...
*  Robert Courrier
http://www.adamantane.org/article-6172722.html "Robert Courrier. 6 October 1895-14 March 1986", Jamshed R. Tata, Biographical ...
*  Discovery and development of neuraminidase inhibitors
They are the adamantanes and NAIs. The adamantanes only work on influenza A so since 2010 WHO recommended the usage of NAIs for ... In contrast to adamantanes, NAIs are less toxic and less prone to promote drug-resistant influenza. Moreover, they are ... Neuraminidase Neuraminidase inhibitors Influenza virus Adamantane Christopher W. Cairo. (2014) Inhibitors of the human ...
*  Dye laser
Adamantane is added to some dyes to prolong their life. Cycloheptatriene and cyclooctatetraene (COT) can be added as triplet ...
*  NMDA receptor
This finding, reported by Scawab et al., was the beginning of medicinal chemistry of adamantane derivatives in the context of ... Before this finding, memantine, another adamantane derivative, had been synthesized by Eli Lilly and Company in 1963. The ... In 1972 a possible therapeutic importance of memantine, an adamantane derivative, was discovered for treating neurodegenerative ... two adamantane derivatives, the affinity for the binding site of NR1/NR2B subunit is much greater for memantine. In patch-clamp ...
*  Tromantadine
Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane. Tromantadine inhibits the early and ...
*  Rimantadine
Both rimantadine and the similar drug amantadine are derivates of adamantane. Rimantadine was approved by the Food and Drug ...
*  Topological drugs
An example of such abiotic (xenobiotic) compounds is the carbocyclic adamantane derivatives. These compounds are widely used in ... The success of the drug therapy of the virus and Parkinson's diseases using abiotic polyhedral adamantane molecules suggests ...
*  Amantadine
It is the organic compound 1-adamantylamine or 1-aminoadamantane, meaning it consists of an adamantane backbone that has an ... These findings may also extend to the other adamantanes such as adapromine, rimantadine, and bromantane, and could explain the ... Rimantadine is a closely related derivative of adamantane with similar biological properties. Apart from medical uses, this ... "Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain ...
*  Td Molecular Orbitals
... and adamantane. Molecular orbitals of Td molecules can be determined using reducible representations, SALCs and projection ...
*  Influenza
Hurt AC, Ho HT, Barr I (October 2006). "Resistance to anti-influenza drugs: adamantanes and neuraminidase inhibitors". Expert ... Centers for Disease Control and Prevention (CDC) (2006). "High levels of adamantane resistance among influenza A (H3N2) viruses ... "Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern ...
Nanotechnology Now - Press Release: Application of Adamantane  Nanotechnology Now - Press Release: Application of Adamantane
Adamantane is one of the main products of Jinxiang chemical factory. We will supply the best adamantane to every customer. ... Home , Press , Application of Adamantane. Abstract:. Adamantane consists of four cyclohexanes fused each other in chair ... Application of Adamantane. Nanjing, China , Posted on November 7th, 2012. Its systematical name is tricyclo[3.3.1.1(3,7)]decane ...
more infohttp://www.nanotech-now.com/news.cgi?story_id=46315
Machine Phase: mechanosynthesis with penta-adamantane  Machine Phase: mechanosynthesis with penta-adamantane
I chose this because it has a similar shape as adamantane, and my collaborators decided we could run with it.. Here is a HD ... The basic idea is a penta-adamantane block is attached to the tooltip by a single covalent bond. The tooltip drops the block ... On the left is adamantane with four hydrogen atoms abstracted. Previous simulations gave reason to suspect it would fail in ... In order to overcome this problem a larger building block was chosen, penta-adamantane, rendered on the right also with four ...
more infohttp://machine-phase.blogspot.com/2008/07/mechanosynthesis-with-penta-adamantane.html
Diamant - Liquid Adamantane For R&D | Ray Peat Forum  Diamant - Liquid Adamantane For R&D | Ray Peat Forum
I first became interested in adamantane when I read about it in one of ray's articles. According to Ray it seems to have a ... Adamantane - Wikipedia. '...Adamantane is a colorless, crystalline chemical compound with a camphor-like odor. With a formula ... The same seems to be true of adamantane.. In summary, based on extensive research and clinical testing adamantane and its ... Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation. - PubMed - NCBI. Adamantane ...
more infohttps://raypeatforum.com/community/threads/diamant-liquid-adamantane-for-r-d.16108/
Molecular evaluation of M2 protein of Iranian avian influenza viruses of H9N2 subtype in order to find mutations of adamantane...  Molecular evaluation of M2 protein of Iranian avian influenza viruses of H9N2 subtype in order to find mutations of adamantane...
Adamantane is a group of antiviral agents which is effective both in prevention and treatment of influenza A virus infections. ... Finally, sequences were checked for possible sites of adamantane resistance mutations. RESULTS: Overall, 8 out of 11 viruses ... of H9N2 subtype in order to find adamantane drug resistance mutations. METHODS: Over 100 suspected samples were collected from ... harbored the adamantane resistance-associated mutations. Of which, four viruses were isolated in 2013 and four viruses in 2012 ...
more infohttps://ijvm.ut.ac.ir/article_59718.html
Rimantadine  Rimantadine
Literature References: Deriv of adamantane, q.v. Prepn: NL 6408505; W. W. Prichard, US 3352912 (1965, 1967 both to du Pont). ...
more infohttp://www.drugfuture.com/chemdata/rimantadine.html
Influenza: Molecular Virology  Influenza: Molecular Virology
... both belonging to the adamantane class of compounds. However, resistance of influenza A to adamantane is now widespread. ... The recently-determined high-resolution structures of M2 in complex with adamantane allow us to begin answering this question. ...
more infohttps://www.caister.com/influenza
Institute for Molecular ManufacturingIMM Report Number 6  Institute for Molecular ManufacturingIMM Report Number 6
In the Science paper, the guest molecules were adamantane and a number of hydroxyl and keto derivatives of adamantane. ... In the case of unmodified adamantane, the NMR signal shows a single sharp peak, demonstrating that rotation of this guest ...
more infohttp://www.imm.org/reports/rep006/
Cdc - influenza (flu) | interim guidance pregnant women and swine influenza: considerations for clinicians  Cdc - influenza (flu) | interim guidance pregnant women and swine influenza: considerations for clinicians
medications zanamivir and oseltamivir, but is resistant to the adamantane antiviral medications, amantadine and rimantadine. ...
more infohttp://finder-articles.com/m/mcms.org1.html
adamantane - Everything2.com  adamantane - Everything2.com
To be more precise, it is four fused cyclohexanes in chair form. To see this it is necessary to see the structure - sadly this is beyond my ASCII art sk...
more infohttps://everything2.com/title/adamantane
Adamantane, 1-chloro  Adamantane, 1-chloro
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
more infohttps://webbook.nist.gov/cgi/inchi/InChI%3D1S/C10H15Cl/c11-10-4-7-1-8
Adamantane - Wikipedia  Adamantane - Wikipedia
Adamantane cationsEdit. The adamantane cation can be produced by reacting 1-fluoro-adamantane with SbF5 and it has high ... Fluorination of adamantane with gaseous fluorine has also been reported.[40]. CarboxylationEdit. Carboxylation of adamantane ... Adamantane analoguesEdit. Many molecules adopt adamantane-like cage structures. Those include phosphorus trioxide P4O6, arsenic ... Adamantane cages can be stacked together to produce higher diamondoids, such as diamantane (C14H20 - two fused adamantane cages ...
more infohttps://en.m.wikipedia.org/wiki/Adamantane
2-(4-methylphenyl)-adamantane  2-(4-methylphenyl)-adamantane
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
more infohttps://webbook.nist.gov/cgi/inchi/InChI%3D1S/C17H22/c1-11-2-4-14
The EPR Spectrum of Na3 in Adamantane | SpringerLink  The EPR Spectrum of Na3 in Adamantane | SpringerLink
... has been prepared in adamantane and its EPR spectrum recorded from 4 to 170 K. It has three magnetically equivalent Na nuclei ... Howard J.A., Hampson C.A., Histed M., Morris H., Mile B. (1987) The EPR Spectrum of Na3 in Adamantane. In: Jena P., Rao B.K., ... The sodium trimer, Na3, has been prepared in adamantane and its EPR spectrum recorded from 4 to 170 K. It has three ... This suggests that the correlation time, τc, is faster in adamantane than it is in argon. ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4757-0357-3_59
Adamantane - Wikipedia  Adamantane - Wikipedia
... adamantane should be called tricyclo[3.3.1.13,7]decane. However, IUPAC recommends using the name "adamantane". The adamantane ... adamantane slowly sublimes even at room temperature. Adamantane can be distilled with water vapor. The adamantane molecule ... Today, adamantane is an affordable chemical compound with a cost of about $1 a gram. All the above methods yield adamantane as ... The adamantane cation can be produced by reacting 1-fluoro-adamantane with SbF5 and it has high stability compared with other ...
more infohttps://en.wikipedia.org/wiki/Adamantane
Phosphatrioxa-adamantane - Wikipedia  Phosphatrioxa-adamantane - Wikipedia
Phosphatrioxa-adamantane is an organophosphorus compound that is used as a precursor to bulky phosphine ligands. Abbreviated ... Paul G. Pringle, Martin B. Smith "Phosphatrioxa-adamantane Ligands" in Phosphorus(III) Ligands in Homogeneous Catalysis: Design ...
more infohttps://en.wikipedia.org/wiki/Phosphatrioxa-adamantane
Molecules | Free Full-Text | Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing Amines  Molecules | Free Full-Text | Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing Amines
7-dichloroquinolines was studied using adamantane-containing amines in which substituents at the nitrogen atom differ in ... Keywords: amines; adamantane; Pd catalysis; amination; quinoline amines; adamantane; Pd catalysis; amination; quinoline ... Pd-catalyzed amination of isomeric 2,6-, 2,8-, 4,8- and 4,7-dichloroquinolines was studied using adamantane-containing amines ... Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing Amines. Anton S. Abel 1. ...
more infohttp://www.mdpi.com/1420-3049/18/2/2096
39269-10-8 - Adamantane-1,3-dicarboxylic acid, 98% - H60081 - Alfa Aesar  39269-10-8 - Adamantane-1,3-dicarboxylic acid, 98% - H60081 - Alfa Aesar
Alfa Aesar is a leading manufacturer and supplier of research chemicals, pure metals and materials for a wide span of applications.
more infohttps://www.alfa.com/en/catalog/H60081/
A novel prototype of albumin nanoparticles fabricated by supramolecular cyclodextrin-adamantane association. | Sigma-Aldrich  A novel prototype of albumin nanoparticles fabricated by supramolecular cyclodextrin-adamantane association. | Sigma-Aldrich
These NPs (GC-CD/HSA-ADA NPs) consisted of β-cyclodextrin-modified glycol chitosan (GC-CD) and adamantane-conjugated human ... In this article, we introduce a new albumin NPs prototype fabricated via a 'host' (β-cyclodextrin)-'guest' (adamantane) ... A novel prototype of albumin nanoparticles fabricated by supramolecular cyclodextrin-adamantane association.. [Seunghyun Lee, ...
more infohttps://www.sigmaaldrich.com/catalog/papers/27522557
Computational Organic Chemistry » adamantane  Computational Organic Chemistry » adamantane
2 The barrier for rearrangement of the inverted adamantane into adamantane, which involved a cleave of a C-C bond, is 17 kcal ... Archive for the 'adamantane' Category. 1-Adamantyl cation - Predicting its NMR spectra. What is required in order to compute ... Inverted adamantane. There is a mystique surrounding chemical torture. Just how much strain can one subject a poor old carbon ... 1) Irikura, K. K., 'In-Adamantane, a Small Inside-Out Molecule,' J. Org. Chem. 2008, 73, 7906-7908, DOI: 10.1021/jo801806w. ...
more infohttp://comporgchem.com/blog/?cat=48
Dissociative ionisation of adamantane: a combined theoretical and experimental study - Physical Chemistry Chemical Physics (RSC...  Dissociative ionisation of adamantane: a combined theoretical and experimental study - Physical Chemistry Chemical Physics (RSC...
We have found adamantane to dissociatively photoionise via several parallel channels of which H, C3H7 and C4H8 losses are the ... Dissociative ionisation of adamantane: a combined theoretical and experimental study A. Candian, J. Bouwman, P. Hemberger, A. ... In this paper we characterise the dissociative ionisation of adamantane (C10H16) - the smallest member of the diamondoid family ... which is located at 10.55 eV with respect to neutral adamantane. In addition, we found dissociation channels leading to small ...
more infohttp://pubs.rsc.org/en/content/articlelanding/2018/cp/c7cp05957d
Computational Organic Chemistry » Inverted adamantane  Computational Organic Chemistry » Inverted adamantane
2 The barrier for rearrangement of the inverted adamantane into adamantane, which involved a cleave of a C-C bond, is 17 kcal ... Inverted adamantane. There is a mystique surrounding chemical torture. Just how much strain can one subject a poor old carbon ... 1) Irikura, K. K., 'In-Adamantane, a Small Inside-Out Molecule,' J. Org. Chem. 2008, 73, 7906-7908, DOI: 10.1021/jo801806w. ... One Response to "Inverted adamantane". * syregnask. responded on 05 Mar 2009 at 4:24 am # ...
more infohttp://comporgchem.com/blog/?p=97
Control of an Outbreak due to an Adamantane-Resistant Strain of Influenza A (H3N2) in a Chronic Care Facility | SpringerLink  Control of an Outbreak due to an Adamantane-Resistant Strain of Influenza A (H3N2) in a Chronic Care Facility | SpringerLink
Adamantanes have been used by chronic care facilities for influenza A prophylaxis; however, genotypic resistance ha ... Adamantanes have been used by chronic care facilities for influenza A prophylaxis; however, genotypic resistance has altered ... Control of an Outbreak due to an Adamantane-Resistant Strain of Influenza A (H3N2) in a Chronic Care Facility. ... Enhanced infection control precautions and adamantane prophylaxis were used to control spread of influenza in a chronic care ...
more infohttps://link.springer.com/article/10.1007%2Fs15010-008-7295-9
The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element...  The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element...
We have described previously that N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin (AMP-DNM), an inhibitor of ... The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element ... The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element ... The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element ...
more infohttp://jpet.aspetjournals.org/content/326/3/849
  • In chemistry, diamondoids are variants of the carbon cage molecule known as adamantane (C10H16), the smallest unit cage structure of the diamond crystal lattice. (wikipedia.org)
  • Adamantane is a group of antiviral agents which is effective both in prevention and treatment of influenza A virus infections. (ac.ir)
  • After digging further I discovered many additional properties that make adamantane quite an interesting substance. (raypeatforum.com)
  • The studies supporting the properties of adamantane described above are provided in the references section below. (raypeatforum.com)
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