A family of membrane-anchored glycoproteins that contain a disintegrin and metalloprotease domain. They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain.
ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
A genus of RNA plant viruses as yet unassigned to any family. Plant hosts are all in the family Poaceae. Each species is transmitted by a particular species of planthopper. The type species is Rice stripe virus.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Proteolytic breakdown of the MITOCHONDRIA.
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
Regular course of eating and drinking adopted by a person or animal.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
The functional hereditary units of PLANTS.
Facilities having programs intended to promote and maintain a state of physical well-being for optimal performance and health.
Relations of an individual, association, organization, hospital, or corporation with the publics which it must take into consideration in carrying out its functions. Publics may include consumers, patients, pressure groups, departments, etc.
Prolamins in the endosperm of SEEDS from the Triticeae tribe which includes species of WHEAT; BARLEY; and RYE.
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
A plant genus of the family ORCHIDACEAE that contains dihydroayapin (COUMARINS) and phenanthraquinones.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
A class of weak acids with the general formula R-CONHOH.
Compounds with BENZENE fused to AZEPINES.
Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
The third stomach of ruminants, situated on the right side of the abdomen at a higher level than the fourth stomach and between this latter and the second stomach, with both of which it communicates. From its inner surface project large numbers of leaves or folia, each of which possesses roughened surfaces. In the center of each folium is a band of muscle fibers which produces a rasping movement of the leaf when it contracts. One leaf rubs against those on either side of it, and large particles of food material are ground down between the rough surfaces, preparatory to further digestion in the succeeding parts of the alimentary canal. (Black's Veterinary Dictionary, 17th ed)
Uptake of substances through the lining of the INTESTINES.
Peptides composed of two amino acid units.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. (1/1953)

Amyloid beta peptide (Abeta), the principal proteinaceous component of amyloid plaques in brains of Alzheimer's disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP). Proteolytic cleavage of APP by a putative alpha-secretase within the Abeta sequence precludes the formation of the amyloidogenic peptides and leads to the release of soluble APPsalpha into the medium. By overexpression of a disintegrin and metalloprotease (ADAM), classified as ADAM 10, in HEK 293 cells, basal and protein kinase C-stimulated alpha-secretase activity was increased severalfold. The proteolytically activated form of ADAM 10 was localized by cell surface biotinylation in the plasma membrane, but the majority of the proenzyme was found in the Golgi. These results support the view that APP is cleaved both at the cell surface and along the secretory pathway. Endogenous alpha-secretase activity was inhibited by a dominant negative form of ADAM 10 with a point mutation in the zinc binding site. Studies with purified ADAM 10 and Abeta fragments confirm the correct alpha-secretase cleavage site and demonstrate a dependence on the substrate's conformation. Our results provide evidence that ADAM 10 has alpha-secretase activity and many properties expected for the proteolytic processing of APP. Increases of its expression and activity might be beneficial for the treatment of Alzheimer's disease.  (+info)

Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice. (2/1953)

Mammalian angiotensin-converting enzyme (ACE) is one of several biologically important ectoproteins that exist in both membrane-bound and soluble forms as a result of a post-translational proteolytic cleavage. It has been suggested that a common proteolytic system is responsible for the cleavage of a diverse group of membrane ectoproteins, and tumor necrosis factor-alpha-converting enzyme (TACE), a recently purified disintegrin-metalloprotease, has been implicated in the proteolytic cleavage of several cell surface proteins. Mice devoid of TACE have been developed by gene targeting. Such mice could provide a useful system to determine if TACE is responsible for the cleavage of other ectoproteins. Cultured fibroblasts without TACE activity, when transfected with cDNA encoding for the testicular isozyme of ACE (ACET), synthesized and secreted ACET normally after a proteolytic cleavage near the C terminus. In addition, similar quantities of the soluble, C-terminally truncated somatic isozyme of ACE (ACEP) were present in the serum of wild-type and TACE-deficient mice. These results demonstrate that TACE is not essential in the generation of soluble ACE under physiological conditions. Finally, we also report solubilization of ACE-secretase, the enzyme that cleaves ACE, from mouse ACE89 cells and from rabbit lung. We demonstrate that soluble ACE-secretase from both sources failed to cleave its substrate in solution, suggesting a requirement for anchoring to the membrane.  (+info)

Thrombotic thrombocytopenic purpura and autoimmunity: a tale of shadows and suspects. (3/1953)

BACKGROUND AND OBJECTIVE: The key pathogenic feature of TTP is the formation of platelet aggregates within the microcirculation; however, the etiology of such aggregates has been elusive for years. A large amount of evidence points to an abnormal interaction between damaged vascular endothelium and platelets, although the cause of the primary microvascular endothelial cell injury is seldom clear. The autoimmune hypothesis often recurs, and this is based on a number of observations: the claimed superiority of plasma-exchange over plasma infusion, the anecdotal report of the presence of immunocomplexes and autoantibodies in TTP patients, the efficacy of the administration of corticosteroids and other immunosuppressant agents, and the concomitant occurrence of TTP in association with autoimmune diseases, especially systemic lupus erythematosus (SLE). This review will focus on the complex relationships between TTP and humoral autoimmunity; in particular, similarities and differences between TTP, SLE and antiphospholipid (aPL) antibodies syndrome, as well as the putative role of several other antibodies directed towards endothelial cells and/or platelets, including the recently discovered anti-CD36 antibodies and antivWF-cleaving metalloprotease, will be discussed. DESIGN AND METHODS: The authors have been involved in the study and treatment of TTP and autoimmune diseases for years; furthermore, the PubMed data base of the National Library of Congress has been extensively searched using the Internet. CONCLUSIONS: Although over the years evidence has increased in favor of the autoimmune hypothesis for TTP etiopathogenesis, TTP should not yet be considered an autoimmune disease. Autoantibodies should be regarded as only one of the many different insults which can trigger microvascular thrombosis even though the autoimmune theory of the pathogenesis of TTP is gaining more and more strength. As far as concerns the relationship between TTP, SLE and aPL antibodies-related disorders, these diseases should be distinguished on the basis of both different clinical presentations and accurate antibody screening, although this approach should definitely not delay the prompt start of treatment.  (+info)

Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch. (4/1953)

The ADAMs (a disintegrin and metalloprotease) are a family of multidomain proteins that are believed to play key roles in cell-cell and cell-matrix interactions. We have shown recently that human ADAM 12-S (meltrin alpha) is an active metalloprotease. It is synthesized as a zymogen, with the prodomain maintaining the protease in a latent form. We now provide evidence that the latency mechanism of ADAM 12 can be explained by the cysteine switch model, in which coordination of Zn2+ in the active site of the catalytic domain by a cysteine residue in the prodomain is critical for inhibition of the protease. Replacing Cys179 with other amino acids results in an ADAM 12 proform that is proteolytically active, but latency can be restored by placing cysteine at other positions in the propeptide. None of the amino acids adjacent to the crucial cysteine residue is essential for blocking activity of the protease domain. In addition to its latency function, the prodomain is required for exit of ADAM 12 protease from the endoplasmic reticulum. Tissue inhibitor of metalloprotease-1, -2, and -3 were not found to block proteolytic activity of ADAM 12, hence a physiological inhibitor of ADAM 12 protease in the extracellular environment remains to be identified.  (+info)

Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. (5/1953)

Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE), a member of the TNF family, is a dendritic cell survival factor and is essential for osteoclastogenesis and osteoclast activation. In this report we demonstrate (i) that TRANCE, like TNF-alpha, is made as a membrane-anchored precursor, which is released from the plasma membrane by a metalloprotease; (ii) that soluble TRANCE has potent dendritic cell survival and osteoclastogenic activity; (iii) that the metalloprotease-disintegrin TNF-alpha convertase (TACE) can cleave immunoprecipitated TRANCE in vitro in a fashion that mimics the cleavage observed in tissue culture cells; and (iv) that in vitro cleavage of a TRANCE ectodomain/CD8 fusion protein and of a peptide corresponding to the TRANCE cleavage site by TACE occurs at the same site that is used when TRANCE is shed from cells into the supernatant. We propose that the TRANCE ectodomain is released from cells by TACE or a related metalloprotease-disintegrin, and that this release is an important component of the function of TRANCE in bone and immune homeostasis.  (+info)

Deficient activity of von Willebrand's factor-cleaving protease in patients with disseminated malignancies. (6/1953)

An aberrant platelet immunorelated glycoprotein Ib (GPIb) receptor expressed by human tumor cells appears to participate in primary adhesive interactions required for the metastatic process. Hence, we questioned whether plasma von Willebrand's factor (vWf), its adhesive ligand, manifested comparable anomalies in patients with disseminated tumors. Plasma specimens from patients with disseminated metastases showed 68% (P < 0.013), 91% (P < 0.0009), and 207% (P < 0.0009) enhancements in FVIII:C activity, vWf-related antigen levels, and ristocetin co-factor activity, respectively, whereas their SDS-agarose electrophoretic analysis demonstrated a 165% (P < 0.001) increase in the highly polymeric forms of vWf compared to control preparations from patients with corresponding, localized solid tumors. Substantially reduced levels of vWf-cleaving protease activity were observed in study patient specimens, with no plasma inhibitors detectable. The clinical presence and absence of tumor metastases correlated significantly with vWf-cleaving enzyme activities of < or = 15% and > or = 88%, respectively (n = 20; P < 0.0001). Finally, with an in vitro model system, tumor-induced platelet aggregation was enhanced by 127% (P < 0.001) in study patient platelet-rich plasma (PRP) compared to control PRP and could be completely inhibited (P < 0.0009) when both tumor cells and their PRP substrates were incubated with monoclonal antibodies directed against the vWf binding epitope of GPIb alpha and against the GPIb binding epitope of plasma vWf, respectively. Unusually large vWf multimers observed in patients with disseminated tumors probably result from deficient vWf-cleaving protease activity and may represent a novel mechanism regulating primary platelet-tumor adhesive interactions involved in the metastatic process.  (+info)

Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion. (7/1953)

The ADAMs (A disintegrin and metalloprotease) comprise a family of membrane-anchored cell surface proteins with a putative role in cell-cell and/or cell-matrix interactions. By immunostaining, ADAM 12 (meltrin alpha) was up-regulated in several human carcinomas and could be detected along the tumor cell membranes. Because of this intriguing staining pattern, we investigated whether human ADAM 12 supports tumor cell adhesion. Using an in vitro assay using recombinant polypeptides expressed in Escherichia coli, we examined the ability of individual domains of human ADAM 12 and ADAM 15 to support tumor cell adhesion. We found that the disintegrin-like domain of human ADAM 15 supported adhesion of alphavbeta3-expressing A375 melanoma cells. In the case of human ADAM 12, however, recombinant polypeptides of the cysteine-rich domain but not the disintegrin-like domain supported cell adhesion of a panel of carcinoma cell lines. On attachment to recombinant polypeptides from the cysteine-rich domain of human ADAM 12, most tumor cell lines, such as MDA-MB-231 breast carcinoma cells, were rounded and associated with numerous actin-containing filopodia and used a cell surface heparan sulfate proteoglycan to attach. Finally, we demonstrated that authentic full-length human ADAM 12 could bind to heparin Sepharose. Together these results suggest a novel role of the cysteine-rich domain of ADAM 12 -- that of supporting tumor cell adhesion.  (+info)

Evidence that a functional fertilin-like ADAM plays a role in human sperm-oolemmal interactions. (8/1953)

Fertilin is a protein initially identified in guinea pig spermatozoa; it is the prototype of a larger family of conserved, proteins designated as a disintegrin and a metalloproteinase (ADAM). These heterodimers which consist of alpha and beta subunits, containing metalloproteinase-like and disintegrin-like domains, appear to play a role in mammalian fertilization. Peptides derived from the disintegrin domains of two ADAMs, fertilin and cyritestin, interfere with gamete adhesion and sperm-egg membrane fusion in non-human species. It has been suggested that fertilin-beta binds to an oolemmal integrin, and it is proposed that the tripeptide FEE (Phe-Glu-Glu) is the integrin recognition sequence in human fertilin-beta. We evaluated whether fertilin beta plays a role in human fertilization by studying the effects of a linear octapeptide containing the FEE sequence, SFEECDLP, and a scrambled octapeptide with the same amino acids, SFPCEDEL, on the incorporation of human spermatozoa by human zona-free eggs. The effects of G4120, a potent RGD-containing (Arg-Gly-Asp) thioether-bridged cyclic peptide which blocks both fibronectin and vitronectin receptors, and the relationship between FEE- and RGD-receptor interactions on sperm-egg interactions were also studied. The FEE-containing peptide, but not the scrampled peptide, inhibited sperm adhesion to oocytes and their penetration, over the range 1-5 microM. The inhibition induced by SFEECDLP was reversible and occurred only in the presence of peptide itself. The G4120 peptide exhibited 10-fold less inhibitory effects on sperm adhesion and penetration than did SFEECDLP. When combined, SFEECDLP and G4120 exhibited strong inhibition of both adhesion and penetration at concentrations that individually had been ineffective, suggesting co-operation between the two receptor-ligand interactions during fertilization. We propose that a fertilin-like molecule is functionally active on human spermatozoa and that its interaction with an oolemmal integrin receptor plays a role in fertilization in humans.  (+info)

Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a dual inhibitor of the matrix metalloproteinases (MMPs) and some adamalysins, two families of extracellular and cell surface metalloproteinases that function in extracellular matrix turnover and the shedding of cell surface proteins. The mechanism of inhibition of MMPs by TIMPs has been well characterized, and since the catalytic domains of MMPs and adamalysins are homologous, it was assumed that the interaction of TIMP-3 with adamalysins is closely similar. Here we report that the inhibition of the extracellular region of ADAM-17 (tumor necrosis factor alpha-converting enzyme (TACE)) by the inhibitory domain of TIMP-3 (N-TIMP-3) shows positive cooperativity. Also, mutations in the core of the MMP interaction surface of N-TIMP-3 dramatically reduce the binding affinity for MMPs but have little effect on the inhibitory activity for TACE. These results suggest that the mechanism of inhibition of ADAM-17 by TIMP-3 may be distinct from that for MMPs. The
TY - JOUR. T1 - The disintegrin-like metalloproteinase ADAM 10 is involved in coinstitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. AU - Hundhausen, C.. AU - Misztela, D.. AU - Berkhout, Theo. AU - Broadway, N.. AU - Saftig, P.. AU - Reiss, K.. AU - Hartmann, D.. AU - Fahrenholz, F.. AU - Postina, R.. AU - Matthews, J.. AU - Kallen, K.J.. AU - Rose-John, S.. AU - Ludwig, A.. PY - 2003/8/15. Y1 - 2003/8/15. N2 - The CX3C chemokine fractalkine (CX3CL1) exists as a membrane-expressed protein promoting cell-cell adhesion and as a soluble molecule inducing chemotaxis. Transmembrane CX3CL1 is converted into its soluble form by defined proteolytic cleavage (shedding), which can be enhanced by stimulation withphorbol-12-myristate-13-acetate (PMA). PMA-induced CX3CL1 shedding has been shown to involve the tumor necrosis factor-alpha-converting enzyme (TACE), whereas the constitutive cleavage in unstimulated cells remains elusive. Here we demonstrate a role of ...
Adam protein (A Disintegrin and Metalloproteinase Protein) is a family of peptidase proteins[1]. ADAMs are also known as the Adamalysin family. ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM 10 can cut off part of the HER2 receptor, activating it[2] and ADAM 17 can cut off part of the EGFR once it has bound its ligand, freeing the ligand to go and stimulate another cell[3]. Therapeutic ADAM inhibitors can potentiate anti-cancer therapy[citation needed]. It is categorized under EC 3.4.24.46. Types include: ...
in Molecular Medicine (2006), 12(7-8, Jul-Aug), 171-179. ADAMs (a disintegrin and metalloprotease) constitute a family of cell surface proteins containing disintegrin and metalloprotease domains which associate features of adhesion molecules and proteases ... [more ▼]. ADAMs (a disintegrin and metalloprotease) constitute a family of cell surface proteins containing disintegrin and metalloprotease domains which associate features of adhesion molecules and proteases. ADAMTSs (a disintegrin and metalloprotease with thrombospondin motifs) bear thrombospondin type I motifs in C-terminal extremity, and most of them are secreted proteins. Because genetic studies have shown that ADAM-33 gene polymorphisms are associated with asthma, we designed this study to assess mRNA expression profile of several ADAM and ADAMTS proteases in sputum from patients with asthma and to investigate the relationship between expression of these proteases and asthma-associated inflammation and airway obstruction. mRNA ...
TY - JOUR. T1 - A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. AU - Leonardi, Emanuela. AU - Andreazza, Simonetta. AU - Vanin, Stefano. AU - Busolin, Giorgia. AU - Nobile, Carlo. AU - Tosatto, Silvio C E. PY - 2011/3/29. Y1 - 2011/3/29. N2 - Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome. The LGI1 gene seems to have a role on the transmission of neuronal messages but the exact molecular mechanism remains unclear. In contrast to other genes involved in epileptic disorders, epitempin shows no homology with known ion channel genes but contains two domains, composed of repeated structural units, known to mediate protein-protein interactions. A three dimensional in silico model of the two epitempin domains was built to predict the structure-function relationship and propose a functional model integrating ...
Disintegrin-like metalloproteases (ADAMs) comprise the major family of ectodomain sheddases. In inflammatory settings, ADAMs mediate signaling of cytokines, including TNFα and IL-6, and control leukocyte recruitment by the cleavage of cell adhesion molecules. ADAM17 and ADAM10 have been implicated in diverse diseases associated with inflammation, including psoriasis, asthma, arthritis, atherosclerosis, inflammation associated tumors, diabetes and Alzheimers disease (AD) [1-3]. With regard to the latter, it is assumed that decreased α-secretase (ADAM10 and ADAM17) activity and increased β-secretase (BACE1) activity results in abnormal processing of the amyloid precursor protein (APP). This leads to elevated levels of neurotoxic amyloid β, a key pathognomonic feature of AD. Due to the important role of ADAMs and BACE in amyloid β production, altering the ADAM10/17 and/or BACE function are being considered as a promising therapeutic approach to AD [4].. Although ADAM10 and ADAM17 were ...
Abstract. The transmembrane protein ADAM22 is expressed at high levels in the brain. From its molecular structure, ADAM22 is thought to be an adhesion molecule or a receptor because it has functional disintegrin-like and cysteine-rich sequences in its ectodomain. The phenotypic analysis of ADAM22-deficient mice has indicated the important roles played by ADAM22 in proper neuronal function and peripheral nerve development, however, the precise molecular function of ADAM22 is still unknown. To understand the function of ADAM22 on a molecular basis, we identified ADAM22 binding proteins by using immunoprecipitation and mass spectrometric analysis. This analysis revealed that Leucine-rich glioma inactivated 1 (LGI1) is the most potent ADAM22 binding protein in mouse brain. By our quantitative cell-ELISA system, we demonstrated the specific binding of LGI1 with ADAM22. Furthermore, we showed that LGI4, a putative ADAM22 ligand, also bound to ADAM22. Characterization of the binding specificity of LGI1 ...
ADAM (a disintegrin and metalloproteinase) 10 is a key member of the ADAM family of disintegrin and metalloproteinases which process membrane-associated proteins to soluble forms in a process known as shedding. Among the major targets of ADAM10 are Notch, EphrinA2 and CD44. In many cell-based studies of shedding, the activity of ADAM10 appears to overlap with that of ADAM17, which has a similar active-site topology relative to the other proteolytically active ADAMs. The tissue inhibitors of metalloproteinases, TIMPs, have proved useful in the study of ADAM function, since TIMP-1 inhibits ADAM10, but not ADAM17; however, both enzymes are inhibited by TIMP-3. In the present study, we show that, in comparison with ADAM17 and the MMPs (matrix metalloproteinases), the N-terminal domains of TIMPs alone are insufficient for the inhibition of ADAM10. This knowledge could form the basis for the design of directed inhibitors against different metalloproteinases.. ...
specificalIntended Uses: This ADAM10 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human ADAM10. This ELISA kit for research use only, not for therapeutic or diagnostic applications! Principle of the Assay,,ADAM10 ELISA kit applies the competitive enzyme immunoassay technique utilizing a polyclonal anti-ADAM10 antibody and an ADAM10-HRP conjugate. The assay sample and buffer are incubated together with ADAM10-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the ADAM10 concentration since ADAM10 from ...
The Adam and Dr. Drew Show. Guest - The Love Between The Two Hosts. Recorded 07-28-2015 - Release Date 07-30-2015. Production Number #259 - The Syndrome. Show Page. Adam opens the show with the standard intro, Drew says hes trying to recover from being yelled at, Adam addresses The Syndrome at play, the same think Dr. Bruce has but in a milder form.. Adam is now continuing his argument about ID and what Dr. Drew uses for airport security.. Adam is breaking down Dr. Bruces syndrome and how he doesnt know hes alive unless Adam is yelling at him.. Adam says that Bruce needs to be yelled at, like a battered woman seeking to recreate the trauma of her past, Drew is connecting this to Bruce and his family of origin.. Drew says Adam needs to yell while these people need him to yell at them, Adam says he doesnt yell at Mark Geragos and says you can measure his yelling by the order of biggest fuck ups.. Adam talks about what a klutz does or doesnt do, Adam is talking about shedding foam rubber ...
Clone REA331 recognizes the human CD156a antigen, a single-pass type I transmembrane protein which is also known as disintegrin or metalloproteinase domain-containing protein 8 (ADAM8). The ADAM family members are membrane-anchored proteins with wide ranging functions, including proteolytic cleavage of cell surface molecules, cell fusion, cell adhesion, and intracellular signaling. CD156a is expressed mainly in cells of the immune system, such as monocytes, neutrophils, eosinophils, dendritic cells, and B cells. As for most ADAM family members, CD156a is involved in ectodomain shedding of membrane proteins like CD23 and L-selectin and is linked to allergic inflammation and neurodegeneration.Additional information: Clone REA331 displays negligible binding to Fc receptors. | Principat dAndorra
Many guidance receptors are proteolytically cleaved by membrane-associated metalloproteases of the ADAM family, leading to the shedding of their ectodomains. Ectodomain shedding is crucial for receptor signaling and function, but how this process is controlled in neurons remains poorly understood. Here, we show that the transmembrane protein Lrig2 negatively regulates ... read more ADAM-mediated guidance receptor proteolysis in neurons. Lrig2 binds Neogenin, a receptor for repulsive guidance molecules (RGMs), and prevents premature Neogenin shedding by ADAM17 (TACE). RGMa reduces Lrig2-Neogenin interactions, providing ADAM17 access to Neogenin and allowing this protease to induce ectodomain shedding. Regulation of ADAM17-mediated Neogenin cleavage by Lrig2 is required for neurite growth inhibition by RGMa in vitro and for cortical neuron migration in vivo. Furthermore, knockdown of Lrig2 significantly improves CNS axon regeneration. Together, our data identify a unique ligand-gated mechanism to ...
Purified Recombinant Human ADAM33 293 Cell Lysate from Creative Biomart. Recombinant Human ADAM33 293 Cell Lysate can be used for research.
Results-Treatment with recombinant ADAMTS 13 (rADAMTS 13) reduced the levels of chemokines and cytokines, myeloperoxidase activity, and microglia activation and neutrophil recruitment after ICH. rADAMTS 13 also decreased interleukin-6 expression in brain endothelial cells stimulated by lipopolysaccharide, whereas recombinant von Willebrand factor reversed this effect. The anti-inflammatory effect of rADAMTS 13 was accompanied by reduced expression of intercellular adhesion molecule-1 and less activation of matrix metalloproteinase, enhanced pericyte coverage of brain microvessels, and attenuated BBB disruption. Furthermore, neutrophil depletion protected against BBB damage, and rADAMTS 13 treatment had no further beneficial effect. Finally, treatment of mice with rADAMTS 13 reduced cerebral edema and hemorrhagic lesion volume and improved neurological functions. ...
ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was linked to clinical aggressiveness in breast cancer, yet little was known about how this splice variant affects the function of ADAM15. Here, we show that ADAM15B has enhanced catalytic activity in cell-based assays compared with ADAM15A, which lacks a Src-binding site, using shedding of fibroblast growth factor receptor 2iiib variant as an assay for catalytic activity. Moreover, the enhanced activity of ADAM15B compared with ADAM15A depends on Src because it is abolished by Src-kinase inhibitors and in Src(-/-) cells, but not in Src(-/-) cells rescued with Src. These findings provide insights into the mechanism of how a splice variant linked to clinical agressiveness in breast cancer causes increased activity of ADAM15B, and suggest that inhibitors of the ADAM15 protease activity or of the
ADAMTS-20 is a 1,906 amino acid protein of the large family of secreted zinc-dependent metalloproteases known as the ADAMTS (a disintegrin and metalloprotease domain, with thrombospondin type-1 repeats) family (Figure 3). ADAMTS-20 has an N-terminal signal peptide and a propeptide domain which contains three conserved Cys residues and ends in a basic region (aa 246-259). Following the prodomain, ADAMTS-20 contains the zinc-coordinating catalytic sequence HELGHVFNVPHD (aa 399-410) that is closely related to sequences found in metalloproteases. The catalytic domain of ADAMTS-20 is followed by a disintegrin-like domain similar in size and structure amongst all ADAMTS proteins (76 residues) and includes eight conserved Cys residues. The disintegrin domain precedes a single thrombospondin type I repeat (TSP1) which is well-conserved and similar to a domain in Thrombospondin I. The first TSP1 repeat is followed by a cysteine (Cys)-rich domain that has ten conserved Cys residues as well as a spacer ...
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are ubiquitous transmembrane molecular scissors which proteolytically cleave, or shed, the extracellular regions of other transmembrane proteins. ADAM10 is essential for development because it cleaves Notch proteins to induce Notch signaling and regulate cell fate decisions. ADAM17 is regarded as a first line of defense against injury and infection, by releasing tumor necrosis factor α (TNFα) to promote inflammation and epidermal growth factor (EGF) receptor ligands to maintain epidermal barrier function. However, the regulation of ADAM10 and ADAM17 trafficking and activation are not fully understood. This review will describe how the TspanC8 subgroup of tetraspanins (Tspan5, 10, 14, 15, 17, and 33) and the iRhom subgroup of protease-inactive rhomboids (iRhom1 and 2) have emerged as important regulators of ADAM10 and ADAM17, respectively. In particular, they are required for the enzymatic maturation and trafficking to the cell surface of ...
BIOZYME, INC. BioZyme, Inc. is the only company to offer both selective and sensitive fluorescence substrates (FRET) for the Matrix Metalloproteinase (MMP) and A Disintegrin and Metalloproteinase (ADAM) Family members. We also have the most competitive pricing for fluorescence substrates (FRET) for the Matrix Metalloproteinase (MMP) and A Disintegrin and Metalloproteinase (ADAM) Family members as well as recombinant human ADAM8 enzyme.. See our online catalog or our individual Product Sheets located on this website.. Many of Biozyme, Inc. ADAM and MMP fluorescent substrates have been used successfully to screen biological samples of all kinds. All of our ADAM substrates and MMP substrates have been used in a technique called proteolytic matrix analysis or PrAMA to decipher the contributions of different metalloproteinase activities in a biological sample even though the substrates are not completely selective. With this technique, the MMP substrates and ADAM substrates have helped quantify MMP9, ...
Barreto-Luis A, Pino-Yanes M, Corrales A, Campo P, Callero A, Acosta-Herrera M, Cumplido J, Ma SF, Martinez-Tadeo J, Villar J, Garcia JG, Carrillo T, Carracedo Á, Blanca M, Flores C. Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene. J Allergy Clin Immunol. 2016 Mar; 137(3):964-6 ...
Allergic asthma severity may be associated with IgE levels. We have shown that beta-2 adrenergic receptor (β2AR) engagement on CD40L/IL-4-primed B cells increases the level of IgE produced per cell, without affecting class switch recombination. β2AR agonists alleviate bronchoconstriction by targeting the β2AR expressed on bronchiolar smooth muscle cells to trigger airway relaxation, but these drugs also target the β2AR on primed B cells, potentially producing an IgE effect that may be counterproductive to the drugs intended use. We reported that surface CD23 expression remained constant on primed B cells exposed to a β2AR agonist, while CD23 mRNA, total CD23 protein, and soluble CD23 (sCD23) increased. Thus, if sCD23 positively regulates IgE production, an increase due to β2AR engagement may worsen bronchoconstriction, albeit relieving it in the short term. We hypothesized that the primary sheddase of CD23, ADAM10, is regulated by β2AR engagement on a primed B cell. Although we found that ...
Clone REA650 recognizes the human ADAM15 antigen, a transmembrane protein, which contains disintegrin and metalloprotease domains. ADAM15 belongs to the membrane linked metalloproteinase family (ADAM), which has gelatinolytic and collagenolytic activities. It has several functions, for example, it is involved in wound healing process and in glomerular cell migration. Furthermore ADAM15 suppresses beta-1 integrins-mediated cell adhesion and migration of smooth muscle cells.Expression of ADAM-15 is found in airway smooth muscle, glomerular mesangial cells, colon, small testine, and chondrocytes. It is highly expressed in atherosclerotic lesions.Additional information: Clone REA650 displays negligible binding to Fc receptors. | Canada
Protein ectodomain shedding is crucial for cell−cell interactions because it controls the bioavailability of soluble tumor necrosis factor-α (TNFα) and ligands of the epidermal growth factor (EGF) receptor, and the release of many other membrane proteins. Various stimuli can rapidly trigger ectodomain shedding, yet much remains to be learned about the identity of the enzymes that respond to these stimuli and the mechanisms underlying their activation. Here, we demonstrate that the membrane-anchored metalloproteinase ADAM17, but not ADAM10, is the sheddase that rapidly responds to the physiological signaling pathways stimulated by thrombin, EGF, lysophosphatidic acid and TNFα. Stimulation of ADAM17 is swift and quickly reversible, and does not depend on removal of its inhibitory pro-domain by pro-protein convertases, or on dissociation of an endogenous inhibitor, TIMP3. Moreover, activation of ADAM17 by physiological stimuli requires its transmembrane domain, but not its cytoplasmic domain, ...
FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is specifically expressed in epididymis where the encoded protein is transferred to the sperm surface during epididymal transit. This gene is located adjacent to a related gene from the ADAM family of proteins on chromosome 14. [provided by RefSeq, Oct 2015 ...
The Adam and Dr. Drew Show. Guest - The Love Between the Two Hosts. Recorded 09-30-2014 - Release Date 10-09-2014. Production Number #181 - Sneaking Out of Bed in the Morning. Show Page. Adam and Drew open hour number 2 with some thanks for supporting the pirate ship, Adam plugs Mangria and explains the show will be Thursday only for the next few weeks, Drew once again thanks the guest hosts for filling in.. Drew asks Adam about his housewarming party, Drew missed it, he was out of town, Adam figured as much.. Adam is now telling everyone to do themselves a favor by throwing a party at their home and picking someone you care about from the airport once per year, youll get your shit in order, clean up your car, and clean the leaves off the roof and the skylights.. Adam is now waxing poetic on cleaning the landscape of your life, going in depth about the cleaning lengths he went to, including getting scuffs of the wall with the scratchy part of the sponge.. Adam has a conversation with Lynette ...
Mutations in A Disintegrin And Metalloprotease (ADAM) 33 gene have been linked to asthma and soluble ADAM33 causes airway remodelling in a transgenic mouse model. This work tests the hypothesis that the effects of human ADAM33 over-expression in transgenic mouse lungs are visible in µCT images as a thickening of the smooth muscle that lines the bronchi and bronchioles, resulting in thicker airway walls as well as narrower lumens than in control mice. Airways were extracted and analysed semi-autonomously for lumen radius, area and perimeter, and wall thickness at seven sites across four generations of branching in 14 murine lungs. However, in a small sample number with limited soft tissue resolution and contrast of the µCT images no significant differences in airway structure could be detected in ADAM33 overexpressing mice compared with control mice ...
Animals have evolved multiple mechanisms to protect themselves from the cumulative effects of age-related cellular damage. Here, we reveal an unexpected link between the TNF (tumour necrosis factor) inflammatory pathway, triggered by the metalloprotease ADAM17/TACE, and a lipid droplet (LD)-mediated mechanism of protecting retinal cells from age-related degeneration. Loss of ADAM17, TNF and the TNF receptor Grindelwald in pigmented glial cells of the Drosophila retina leads to age-related degeneration of both glia and neurons, preceded by an abnormal accumulation of glial LDs. We show that the glial LDs initially buffer the cells against damage caused by glial and neuronally generated reactive oxygen species (ROS), but that in later life the LDs dissipate, leading to the release of toxic peroxidated lipids. Finally, we demonstrate the existence of a conserved pathway in human iPS-derived microglia-like cells, which are central players in neurodegeneration. Overall, we have discovered a pathway mediated
Human CellExp ADAM12, human recombinant protein, ADAM12, MCMP, MLTN, MLTNA, MCMPMltna, Meltrin Alpha validated in (PBV10869r-10), Abgent
NORTH ADAMS, Mass. - Dr. Leigh LoPresti has joined the primary care team at CHP North Adams Family Medical and Dental. A family medicine physician, LoPresti is a former chief medical...
Buy ADAM10 recombinant protein, A Disintegrin and Metalloproteinase Domain 10 Recombinant Protein-NP_001101.1 (MBS143712) product datasheet at MyBioSource, Recombinant Proteins
fertilin: fertilin is a sperm surface protein involved in sperm-egg fusion; consists of two subunits, fertilin alpha and beta, both of which belong to the metalloprotease-disintegrin protein family; RefSeq NM_172126 (Adam1a, mouse); NM_172125 (Adam1b, mouse); NM_009618 (Adam2, mouse); NM_020078 (Adam1a, rat); NM_020077 (Adam2, rat); NM_001464 (ADAM2, human)
The transmembrane metalloprotease ADAM10 sheds a range of cell surface proteins, including ligands and receptors of the Notch, Eph, and erbB families,
Due to their limited shelf life, the ImmunoTag™ ELISA kits are not typically stocked as finished goods. Please allow 2-3 weeks for delivery. Upon receipt of an order each kit is assembled and tested to ensure that it meets specifications before shipping. Minor changes may occur to the Range, Sensitivity, and Precision and is reflected in the manual supplied with the kit (online manuals are for reference only). In the event of a significant change the order would be confirmed with the customer before shipping ...
ADAMTS are metalloproteases with disintegrin and thrombospondin motifs. They are secreted proteases playing a role in biological processes such as inflammation,
No we are not inbred. On the fifth day God created the first Adams. They were many Adams or humans, who were infact able to procreate on their own it seems being completely God like. All until the Adam of YHWH couldnt find anyone he could love. No matter who he would choose among those perfect creatures of God, he could never feel that he owned it, or that she could be the part of him that he missed. He had it all, he didnt need anything the other Adams had. Then YHWH let a deep sleep come uppon the Adam, and he took a cell from his body, and he physically closed or stitched up the shameful wound down there. The text actually says that. That the first humans were created like malefemales. What today would be called shemales or transsexual. I have reasons to believe that while our Adam stayed human many of the other Adams ascended into angelity, and some of these later stepped down to rape Adams daughters resulting in bizarre creatures, monsters and giants. I also believe that some of the ...
Human ADAM9 ELISA Kit for serum, plasma and cell culture supernatants and urine; find Sigma-Aldrich-RAB0528 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to sn
3989 ADAM9, a member of the A Disintegrin And Metalloprotease family of proteins, is a membrane-anchored protein containing an SH3 domain-containing cytoplasmic tail and an extracellular domain comprised of a pro-domain, metalloprotease domain, disintegrin domain, cystein-rich domain, and an epidermal growth factor repeat. ADAM9 has been shown to regulate E-Cadherin internalization and participate in integrin-mediated adhesion processes, and is thought to play a role in tumor aggressiveness. We have developed an ADAM9-specific monoclonal antibody, termed KID24, which is the first reported antibody that inhibits the catalytic activity of ADAM9 in vitro. Immunohistochemical analysis demonstrated KID24 exhibits preferential staining of human tumor tissue over normal tissue. Elevated KID24 staining was observed in lung, colon, pancreatic and prostate adenocarcinomas, confirming previous reports defining ADAM9 as a tumor-associated antigen. ADAM9 is also expressed by a number of Raven cancer stem ...
Weight: The ADAM program uses censuses and propensity scoring to develop sample weights. Sample weights for each location for each year were renormalized so that the sum of all weights equaled the number of cases. This assured that the multi-year analysis would give the appropriate weight to data collected in any given year proportional to the number of cases collected. These weights were used in all statistical calculations to provide unbiased estimates for the target population of adult male arrestees at each location. Data Source: ARRESTEE DRUG ABUSE MONITORING (ADAM) PROGRAM IN THE UNITED STATES, 2000 (ICPSR 3270). ARRESTEE DRUG ABUSE MONITORING (ADAM) PROGRAM IN THE UNITED STATES, 2001 (ICPSR 3688). ARRESTEE DRUG ABUSE MONITORING (ADAM) PROGRAM IN THE UNITED STATES, 2002 (ICPSR 3815). ARRESTEE DRUG ABUSE MONITORING (ADAM) PROGRAM IN THE UNITED STATES, 2003 (ICPSR 4020). ARRESTEE DRUG ABUSE MONITORING PROGRAM II IN THE UNITED STATES, 2007 (ICPSR 25821). ARRESTEE DRUG ABUSE MONITORING PROGRAM ...
Weight: The ADAM program uses censuses and propensity scoring to develop sample weights. Sample weights for each location for each year were renormalized so that the sum of all weights equaled the number of cases. This assured that the multi-year analysis would give the appropriate weight to data collected in any given year proportional to the number of cases collected. These weights were used in all statistical calculations to provide unbiased estimates for the target population of adult male arrestees at each location. Data Source: ARRESTEE DRUG ABUSE MONITORING (ADAM) PROGRAM IN THE UNITED STATES, 2000 (ICPSR 3270). ARRESTEE DRUG ABUSE MONITORING (ADAM) PROGRAM IN THE UNITED STATES, 2001 (ICPSR 3688). ARRESTEE DRUG ABUSE MONITORING (ADAM) PROGRAM IN THE UNITED STATES, 2002 (ICPSR 3815). ARRESTEE DRUG ABUSE MONITORING (ADAM) PROGRAM IN THE UNITED STATES, 2003 (ICPSR 4020). ARRESTEE DRUG ABUSE MONITORING PROGRAM II IN THE UNITED STATES, 2007 (ICPSR 25821). ARRESTEE DRUG ABUSE MONITORING PROGRAM ...
Adam provides technical strategy and expertise to POP and is currently a Director of Software Engineering at Capital One. Prior to Capital One, Adam spent nearly a decade in the professional services industry as a senior leader executing cloud strategies for Fortune 500 companies.. Adam is rooted in his passion for optimizing teams and solutions to advance companies into a modern workforce. Uniquely skilled and certified in management and enterprise architecture, Adam has had the pleasure of gaining experience across diverse industries from startups to Fortune 500 companies. Versatile, driven, and accomplished, with expertise that spans the entire project life cycle, Adam bridges the gap between business strategy and technology delivery.. Adam has been active outside of his primary role as well with key contributions as president of a technology user group, voted Top 50 Microsoft blogger, as well as a frequent public speaker at many technology focused conferences. ...
Buy anti-ADAMTS2 antibody, Mouse anti-Bovine A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) Monoclonal Antibody-NP_055059.2 (MBS2082091) product datasheet at MyBioSource, Primary Antibodies. Application: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA (EIA)
von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. Blood. 2009 Oct 08; 114(15):3329-34 ...
TY - JOUR. T1 - Posttransplantation thrombotic thrombocytopenic purpura. T2 - A single-center experience and a contemporary review. AU - Elliott, Michelle A.. AU - Nichols, William L.. AU - Plumhoff, Elizabeth A.. AU - Ansell, Stephen M.. AU - Dispenzieri, Angela. AU - Gastineau, Dennis A.. AU - Gertz, Morie A.. AU - Inwards, David J.. AU - Lacy, Martha Q.. AU - Micallef, Ivana N.M.. AU - Tefferi, Ayalew. AU - Lrrzow, Mark R.. PY - 2003/4/1. Y1 - 2003/4/1. N2 - Objective: To assess the activity of von Willebrand factor-cleaving protease (vWF-CP) in patients with thrombotic thrombocytopenic purpura (TTP) complicating bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT). Patients and Methods: From March 1, 1999, to June 30, 2001, allogeneic and autologous hematopoietic stem cell transplantation was performed in 118 and 400 patients, respectively. We reviewed risk factors for development of posttransplantation TTP and measured vWF-CP activity during active TTP in ...
Looking for online definition of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 10 in the Medical Dictionary? A Disintegrin and Metalloproteinase with Thrombospondin Motifs 10 explanation free. What is A Disintegrin and Metalloproteinase with Thrombospondin Motifs 10? Meaning of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 10 medical term. What does A Disintegrin and Metalloproteinase with Thrombospondin Motifs 10 mean?
Looking for online definition of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 in the Medical Dictionary? A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 explanation free. What is A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13? Meaning of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 medical term. What does A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 mean?
Endogenous ADAM (A Disintegrin And Metalloproteinase) proteins are known to contain a disintegrin-like domain which allows them to bind to integrins. The disintegrin domain of ADAM15 contains an RGD motif, a characteristic which makes it very similar to true snake venom disintegrins, that consistently have shown anti-angiogenic effects in various in vitro and in vivo models. In this study, we explored the anti-angiogenic effects of a human disintegrin, the disintegrin-like domain of ADAM15. This small polypeptide was made recombinantly in the Markland laboratory, encapsulated in liposomes and used for in vivo testing in a MDA-MB-231orthotopic breast carcinoma xenograft model. Our results show that the liposomal formulation of ADAM15 disintegrin (LMAP15) in vivo, increases host survival, decreases tumor size and decreases microvessel density relative to control animals. These findings underscore the potential of LMAP15 as a novel anti-angiogenic form of treatment in breast cancer ...
A hallmark of thrombotic thrombocytopenic purpura (TTP) is destruction of platelets and erythrocytes. It is thought that the greatly reduced proteolytic cleavage of von Willebrand factor [(VWF), a protein that is important for proper blood clotting] seen in TTP patients, provides a clue to the etiology of the disease. In the absence of proteolytic cleavage, VWF multimerizes and leads to pathological platelet aggregation. Levy et al. have identified a mutated gene in TTP patients that may give rise to the serious illness. The gene encodes the long-sought zinc metalloproteinase that cleaves VWF, termed ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type I motif gene 13). ADAMTS13 activity was nearly undetectable in affected TTP patients, reinforcing the suggestion that ADAMTS13 activity is critical for proper VWF enzymatic cleavage and platelet function. See the News & Views by Fosang and Smith for more details.. G. G. Levy, W. C. Nichols, E. C. Lian, T. Foroud, J. N. ...
A disintegrin and metalloproteinase (ADAMs) have been associated with multiple malignancies. ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been found to be overexpressed in squamous cell carcinomas of the lung. A new study showed that ADAM8 is significantly overexpressed in metastasis of squamous cell carcinomas of the head and neck (HNSCC). We determined ADAM8 levels in the serum of 79 HNSCC patients at the time of diagnosis, in 35 patients 3 months after treatment and in 10 patients 1 year after therapy and compared the results to the sera of 31 healthy volunteers. We also constructed tissue microarrays to detect ADAM8 immunohistochemically in 100 patients. The results were correlated with the survival data of the patients to determine the diagnostic and prognostic value. The data demonstrated that patients with high ADAM8 expression in the tumor have worse survival rates. We found that high ADAM8 serum levels correlated with high ADAM8
Jouannet S., Saint-Pol J., Fernandez L., Nguyen V., Charrin S., Boucheix C., Brou C., Milhiet P.E., Rubinstein E.. The metalloprotease ADAM10 mediates the shedding of the ectodomain of various cell membrane proteins, including APP, the precursor of the amyloid peptide Aβ, and Notch receptors following ligand binding. ADAM10 associates with the members of an evolutionary conserved subgroup of tetraspanins, referred to as TspanC8, which regulate its exit from the endoplasmic reticulum. Here we show that 4 of these TspanC8 (Tspan5, Tspan14, Tspan15 and Tspan33) which positively regulate ADAM10 surface expression levels differentially impact ADAM10-dependent Notch activation and the cleavage of several ADAM10 substrates, including APP, N-cadherin and CD44. Sucrose gradient fractionation, single molecule tracking and quantitative mass-spectrometry analysis of the repertoire of molecules co-immunoprecipitated with Tspan5, Tspan15 and ADAM10 show that these two tetraspanins differentially regulate ...
Use:. This fluorescent ADAM substrate was originally described by us in the publication, Fluorescent substrates useful as high-throughput screening tools for ADAM9″. This ADAM substrate is based on the cleavage sequence of precursor TNF-alpha and has been used to assess activity of ADAM17 in single cell assays as well as standard in vitro enzymatic and cell based assays (See publications below). See our Product Sheets for the substrate specificity profile of this substrate. This ADAM substrate is also an excellent substrate for ADAM9 and ADAM10. This substrate is not specific for ADAM family members as it can also be processed by members of the MMP family of proteinases. BioZyme Inc, does sell specific substrates for ADAM or MMP family members (Please see our Product Sheets or Catalog, for the substrate specificity profile). It demonstrates reasonably strong activity against all of those enzymes, with specificity constants, kcat/Km (M-1s-1), ranging from approximately 4 x 103 to 4 x 105. ...
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008 ...
Endothelial barrier dysfunction is a hallmark of ALI. Here, we provide in vitro and in vivo evidence that endothelial ADAM17 plays a critical role in this process. To this end, we used human microvascular endothelial cells of the lung (HMVEC‐L) in culture and endothelium‐specific ADAM17 knockout mice (Tie2‐adam17−/−) to demonstrate that endothelial ADAM17 is critically involved in endothelial barrier dysfunction, oedema formation, cytokine release as well as leukocyte transmigration and recruitment in response to LPS. As shown by successful treatment with GW280264X, ADAM17 may be a worthwhile therapeutic target for the treatment of ALI.. Lipopolysaccharide treatment in vitro and in vivo increased the ADAM17 mRNA expression in cultured lung endothelial cells and in the lungs of mice, respectively. The upregulation was associated with an increase in ADAM17 activity and cleavage of ADAM17 substrates within a similar time frame. Dysregulation of ADAM17 on the level of gene transcription ...
The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity. Proteolytic cleavage leads to the generation of membrane-bound N-terminal fragments and a soluble FasL (sFasL) ectodomain. sFasL can be detected in the serum of patients with dysregulated inflammatory diseases and is discussed to affect Fas-FasL-mediated apoptosis. Using pharmacological approaches in 293T cells, in vitro cleavage assays as well as loss and gain of function studies in murine embryonic fibroblasts (MEFs), we demonstrate that the disintegrin and metalloprotease ADAM10 is critically involved in the shedding of FasL. In primary human T cells, FasL shedding is significantly reduced after inhibition of ADAM10. The resulting elevated FasL surface expression is associated with increased killing capacity and an increase of T cells undergoing AICD. Overall, our findings ...
The identification of the role of ADAM-10 in VE-cadherin shedding poses several challenging questions. An important question is whether the observed effects on endothelial adhesion molecules and cell permeability are unique to ADAM-10 or involve cooperative interactions with other ADAMs. For instance, shedding of vascular cell adhesion molecule-1 can be mediated by ADAM-17.21 Also, binding of ADAM-28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.27 Additionally, ADAM-15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin.28. Because ADAMs have multidomain structure, they are potentially multifunctional with multiple roles depending on their cellular localization. Also, ADAMs may function in concert with other metalloprotease superfamilies such as ADAMTS and MMPs. ADAMTS (a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs) include at least 19 members evolved as nonintegral ...
ADAMS VITAMIX WOMENS HEALTH MULTIVITAMINE FEMEI 90 TABLETE, ADAMS C-1000 VITAMINA C TABLETE MASTICABILE CU AROMA DE PORTOCALE 70 TABLETE, ADAMS C-1000 VITAMINA C TABLETE MASTICABILE CU AROMA DE PORTOCALE 30 TABLETE, ADAMS METILCOBALAMIN 1000 VITAMINA B12 TABLETE MASTICABILE 90 BUCATI, ADAMS METILCOBALAMIN 1000 VITAMINA B12 TABLETE MASTICABILE 30 BUCATI, ADAMS DIABECALM COMPLEX DE VITAMINE 90 CAPSULE , ADAMS POTASSIUM GLUCONATE DE POTASIUM 99 TABLETE 30, ADAMS ECHINACEA SUPLIMENTE ALIMENTARE PENTRU IMUNITATE 30 TABLETE, ADAMS SELENIUM SUPLIMENTE ALIMENTARE 30 TABLETE, ADAMS COENZYMA Q10 100 MG SUPLIMENT ALIMENTAR 90 CAPSULE, ADAMS VITAMIN K2+ CA+ D3 SUPLIMENTE ALIMENTARE 30 TABLETE, ADAMS OMEGA 3 SUPREME 500EPA/250DHA 90 CAPSULE , ADAMS SUBLINGUAL MELATONIN 3MG SUPLIMENT ALIMENTAR 150 TABLETE, ADAMS DHA ALGAE 200 MG SUPLIMENTE ALIMENTARE 30 CAPSULE, ADAMS CALCIUM + D3 SUPLIMENTE ALIMENTARE 90 TABLETE, ADAMS CALCIUM + D3 SUPLIMENTE ALIMENTARE 30 TABLETE, ADAMS COD LIVER OIL ULEI DIN FICAT DE COD 30
Grantley Herbert Adams was born in Government Hill, Barbados, then a British colony. His father, Fitzherbert Adams, was a black man and the head teacher of one of the islands largest primary schools, Saint Giles. His mother, Rosa Frances Adams, was a coloured woman (of mixed African and European descent). By West Indian standards, the Adams family was part of the lower middle class, removed from the endemic poverty that engulfed the disenfranchised black majority.. Like his father, Adams attended Harrisons College, the colonys premier secondary school. In 1919 he won a prestigious island scholarship to Oxford University in England, where he studied law. In England he met intellectuals from the colonized world, many of whom, like himself, had joined the Fabian Society, a socialist movement that supported decolonization and the end of the British Empire. In 1925 Adams returned to Barbados working as a lawyer ... ...
This study reports three main findings that provide insights into the molecular mechanism of leukocyte transmigration. First, endothelial ADAM10 promotes transmigration of T lymphocytes, but not B lymphocytes or neutrophils, in an in vitro flow assay. Second, this function of ADAM10 is mediated via its substrate VE-cadherin, but not CX3CL1 and CXCL16. Third, Tspan5 and Tspan17 regulate VE-cadherin expression and promote lymphocyte transmigration, but the other four ADAM10-interacting TspanC8 tetraspanins do not.. The previously proposed role for endothelial ADAM10 in leukocyte transmigration is based on in vitro transwell assays in the absence of flow (6, 10, 11). One of these studies showed a positive role for endothelial ADAM10 using unstimulated HUVECs at passage two to four, following ADAM10 knockdown or inhibition, and cultured human T cell blasts (6). A second study reported a positive role for endothelial ADAM10 using HUVECs up to passage four, stimulated with IFN-γ and TNF-α and ...
ADAM-like, decysin 1 is a protein that in humans is encoded by the ADAMDEC1 gene. This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during the maturation of dendritic cells. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]. Entrez Gene: ADAM-like, decysin 1. Retrieved 2014-08-16. Mueller, C. G.; Rissoan, M. C.; Salinas, B; Ait-Yahia, S; Ravel, O; Bridon, J. M.; Briere, F; Lebecque, S; Liu, Y. J. (1997). Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. The Journal of Experimental Medicine. 186 (5): 655-63. doi:10.1084/jem.186.5.655. PMC 2199019 . PMID 9271581. Bates, E. E.; Fridman, W. H.; Mueller, C. G. (2002). The ADAMDEC1 (decysin) gene structure: Evolution by duplication in a metalloprotease gene cluster on chromosome 8p12. ...
Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011).
Matrix metalloproteases (MMPs), in particular MMP-2, -9, and -14, play a key role in various aspects of cancer pathology. Likewise, ADAMs (A Disintegrin And Metalloproteases), including ADAM12, are upregulated in malignant tumors and contribute to the pathology of cancers. Here we showed a positive correlation between MMP-14 and ADAM12 expression in human breast cancer. We demonstrated that in 293-VnR and human breast cancer cells expressing ADAM12 at the cell surface, endogenous MMP-14 was recruited to the cell surface, resulting in its activation. Subsequent to this activation, gelatin degradation was stimulated and tumor-cell apoptosis was decreased, with reduced expression of the pro-apoptotic proteins BCL2L11 and BIK. The effect on gelatin degradation was abrogated by inhibition of the MMP-14 activity and appeared to be dependent on cell-surface αVβ3 integrin localization, but neither the catalytic activity of ADAM12 nor the cytoplasmic tail of ADAM12 were required. The significance of ...
BACKGROUND: Thymopoiesis requires thymocyte-stroma interactions and proteases that promote cell migration by degrading extracellular matrix and releasing essential cytokines and chemokines. A role for several members of the A Disintegrin and Metalloprotease (ADAM) family in T cell development has been reported in the past. METHODOLOGY/PRINCIPAL FINDINGS: Here, we present data indicating that the family member ADAM8 plays a role in thymic T cell development. We used qrtPCR on FACS sorted thymic subsets together with immunofluorescence to analyze thymic ADAM8 expression. We found that ADAM8 was expressed in murine thymic stromal cells and at lower levels in thymocytes where its expression increased as cell matured, suggesting involvement of ADAM8 in thymopoiesis. Further flow cytometry analysis revealed that ADAM8 deficient mice showed normal development and expansion of immature thymocyte subsets. There was however an intrathymic accumulation of single positive CD4 and CD8 T cells which was most
ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMTS-1 in regulating migration, invasion and invadopodia formation in breast tumor cell lines. In a series of primary breast tumors, we observed variable levels of ADAMTS-1 mRNA expression but lower levels of ADAMTS-1 protein expression in human breast cancers as compared to normal tissue, with a striking decrease observed in high-malignancy cases (triple-negative for estrogen, progesterone and Her-2). This result prompted us to analyze the effect of ADAMTS-1 knockdown in breast cancer cells in vitro. MDA-MB-231 cells with depleted ADAMTS-1 expression demonstrated increased migration, invasion and invadopodia formation. The regulatory mechanisms underlying the effects of ADAMTS-1 may be related to VEGF,
An extraction is performed to remove a tooth, whether because of disease, crowding, or damage. When extractions are required, the area around the tooth will be numbed and your dentist will remove the tooth. A small amount of bleeding is normal, as your mouth will replace the removed tooth root by forming a blood clot in the area ...
Email: [email protected] Adam is an undergraduate researcher who is majoring in Biochemistry. He was accepted into the Biochemistry Scholars program his sophomore year and has been working in Dr. Craigs Lab since. Adam is looking to pursue a career in medical research. In addition to the Craig lab, Adam has conducted research in both Dr. William Kerrs Lab at SUNY Upstate and in Dr. Alexanders lab at the University of Wisconsin. While working under Dr. Kerr, Adam studied Ship-1 and its effects on childhood leukemia. While with Dr. Alexander, Adam studied Syndecan-1 and its role in adipose differentiation. In Dr. Craigs lab, Adam has been working with Tom studying cytosolic Hsp40 chaperones. More specifically they are looking into interactions between Sis1, Btn2 and Cur1. ...
Another name for the larynx is the voice box, and its in the throat. The larynx is what gives you your voice, whether youre talking, laughing, whispering, singing, or shouting. You can find your larynx by touching the front of your throat and humming. When you feel vibrations under your fingers, youve found it!. When the larynx grows larger during puberty, it sticks out at the front of the throat. This is whats called an Adams apple. Everyones larynx grows during puberty, but a girls larynx doesnt grow as much as a boys does. Thats why boys have Adams apples. Most girls dont have Adams apples, but some do. Its no big deal either way. But why is it called an Adams apple? If you think its called that after the story of the Garden of Eden where Adam ate a piece of the forbidden fruit that got stuck in his throat, youre right. An Adams apple sometimes looks like a small, rounded apple just under the skin in the front of the throat.. This larger larynx also gives boys deeper voices. ...
Another name for the larynx is the voice box, and its in the throat. The larynx is what gives you your voice, whether youre talking, laughing, whispering, singing, or shouting. You can find your larynx by touching the front of your throat and humming. When you feel vibrations under your fingers, youve found it!. When the larynx grows larger during puberty, it sticks out at the front of the throat. This is whats called an Adams apple. Everyones larynx grows during puberty, but a girls larynx doesnt grow as much as a boys does. Thats why boys have Adams apples. Most girls dont have Adams apples, but some do. Its no big deal either way. But why is it called an Adams apple? If you think its called that after the story of the Garden of Eden where Adam ate a piece of the forbidden fruit that got stuck in his throat, youre right. An Adams apple sometimes looks like a small, rounded apple just under the skin in the front of the throat.. This larger larynx also gives boys deeper voices. ...
In this report we have examined a number of aspects of TACE inhibition in human cells. At least three potential issues can be raised with TACE inhibition as a means of inhibiting TNFα production. The first is the potential redundancy of enzymes that can process proTNFα,14-17 which may mean that inhibiting TACE alone would be ineffective in blocking TNFα secretion. The second is the potential to generate significantly increased levels of the biologically active membrane TNFα.19 The third is the ability to inhibit TNF receptor shedding. This might potentially lead to an increase in TNF receptor expression that would make the cells hypersensitive to TNFα stimulation.. The issue of TACE dependency of shedding can be considered in a number of ways. For example, TIMP-1 has been shown to block MMP dependent cleavage but to be ineffective at blocking cell associated TACE activity.23 Likewise, TIMP-3 has been shown to be relatively ineffective against the MMPs but able to inhibit cell TACE activity. ...
Figure 1. Schematic representation of secreted and membrane-bound MMPs and related ADAMs and ADAMTSs involved in angiogenesis. The proteins have various domains with specific functions in common. Key regulators of angiogenesis are indicated by the yellow squares. MT-MMP-1, -2, -3, and probably -5 enhance angiogenesis by their pericellular action (see Figure 4). Similarly MMP-2 and MMP-9 stimulate angiogenesis and can act pericellular by binding to membrane-anchored proteins. Pro-MMP-23 has a transmembrane domain, but this is removed during activation of the protease, making the active enzyme a soluble MMP. Part of the ADAM family members has proteolytic activity, of which ADAM-10,-15, and -17 are known to affect angiogenesis. ADAMTS-1 and the related ADAMTS-4 and -8 also can affect angiogenesis mainly via their thrombospondin (TSP) domains. The MMPs and MT-MMPs are depicted according to Sato50 with some modifications. ...
Gene Information This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules including a propeptide region a metalloproteinase domain a disintegrin-like domain and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth fertility and organ morphology and function. [provided by RefSeq Jul 2008]. ...
ADAM29 - ADAM29 (Myc-DDK-tagged)-Human ADAM metallopeptidase domain 29 (ADAM29), transcript variant 4 available for purchase from OriGene - Your Gene Company.
ADAM30 - ADAM30 (Myc-DDK-tagged)-Human ADAM metallopeptidase domain 30 (ADAM30) available for purchase from OriGene - Your Gene Company.
Two members of the ADAM (a disintegrin and metalloprotease)-family, MADDAM and decysin, were described as dendritic cell (DC) maturation markers. We are interested in monocyte differentiation and investigated in particular the expression pattern of both genes during the differentiation of human monocytes into DC and macrophages (MAC). Both genes are weakly expressed in freshly isolated monocytes. In immature DC decysin mRNA was absent, even after induction of the terminal differentiation of DC by CD40L or tumour necrosis factor-alpha (TNF-alpha). Only in DC maturated by lipopolysaccharide (LPS) strong signals of decysin mRNA were detected. However, MADDAM mRNA was expressed in immature DC and the expression was markedly increased after induction of the terminal DC differentiation by various stimuli. In contrast, MAC showed a high constitutive decysin mRNA expression, but expressed no MADDAM mRNA. On protein level similar results of MADDAM expression were obtained. Stimulation of MAC by LPS did ...
ADAMTSL1 Full-Length MS Protein Standard (NP_443098), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Dr. Adams grew up in Southern California and received his PhD in molecular biology and medical genetics from University of California, Irvine. After receiving his PhD, Dr. Adams worked for several years in the pharmaceutical industry (GlaxoSmithKline) on protein expression in Streptomyces lividens and mutagenesis of human a-1-anti-trypsin for potential human therapy. In 1985, Dr. Adams returned to Southern California and shifted from pharmaceutical research to medical diagnostics. During his many years at Beckman Coulter, Dr. Adams held a number of technical management roles including Director of Molecular Biology, Director of Immunochemistry Core Sciences, and Director of Global R&D for the Prion Business Center. He has management and lab experience in tissue culture, virology, pathogenic microbiology, and the cloning of markers of pathogenesis. Dr. Adams has significant expertise in recombinant protein expression in both eukaryotic and prokaryotic systems; specifically the site directed ...
Adams voice overs Adam Naranjo has recorded thousands of radio & television commercials, narrations, training programs, radio shows, podcasts and audiobooks in many different styles and characters since he started in radio when he was a kid. Voice acting, and vocal audio engineering isnt Adams job, its | Adams Voice Overs
Synonyms for Adam's Apples in Free Thesaurus. Antonyms for Adam's Apples. 9 synonyms for Adams apple: coffee rose, crape jasmine, crepe gardenia, crepe jasmine, East Indian rosebay, Neros crown, pinwheel flower.... What are synonyms for Adam's Apples?
Somatic angiotensin-I converting enzyme (sACE) is a broadly distributed peptidase which plays a role in blood pressure and electrolyte homeostasis by the conversion of angiotensin I into angiotensin II. N-domain isoforms (nACE) with 65 and 90 kDa have been described in body fluids, tissues and mesangial cells (MC), and a 90 kDa nACE has been described only in spontaneously hypertensive rats. The aim of this study was to investigate the existence of proteolytic enzymes that may act in the hydrolysis of sACE generating nACEs in MC. After the confirmation of the presence of ACE sheddases in Immortalized MC (IMC), we purified and characterized these enzymes using fluorogenic substrates specifically designed for ACE sheddases. Purified enzyme identified as a serine protease by N-terminal sequence was able to generate nACE. In the present study, we described for the first time the presence of ACE sheddases in IMC, identified as serine proteases able to hydrolyze sACE in vitro. Further investigations ...
TNF-alpha converting enzyme (TACE) inhibitors are promising agents to treat inflammatory disorders and cancer. We have investigated novel tartrate diamide TACE inhibitors where the tartrate core binds to zinc in a unique tridentate fashion. Incorporating (R)-2-(2-N-alkylaminothiazol-4-yl)pyrrolidines into the left hand side amide of the tartrate scaffold led to the discovery of potent and selective TACE inhibitors, some of which exhibited good rat oral bioavailability. 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.,Dai C, Li D, Popovici-Muller J, Zhao L, Girijavallabhan VM, Rosner KE, Lavey BJ, Rizvi R, Shankar BB, Wong MK, Guo Z, Orth P, Strickland CO, Sun J, Niu X, Chen S, Kozlowski JA, Lundell DJ, Piwinski JJ, Shih NY, Siddiqui MA Bioorg Med Chem Lett. 2011 Jan 6. PMID:21458257[4] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine ...
Methods and Results-Using recombinant proteins and a murine model, we demonstrated that an ADAMTS13 variant truncated after either the eighth thrombospondin type 1 repeat or the spacer domain inhibits ferric chloride-induced arterial thrombosis in ADAMTS13−/− mice with efficacy similar to that of full-length ADAMTS13. The results obtained from monitoring thrombus formation in carotid and mesenteric arteries were highly concordant. Further analyses by site-directed mutagenesis and human monoclonal antibody inhibition assay revealed that the Cys-rich and spacer domains of ADAMTS13, particularly the amino acid residues between Arg559 and Glu664 in the spacer domain, may be critical for modulation of arterial thrombosis in vivo. Finally, the thrombosis-modulating function of ADAMTS13 and variants/mutants was highly correlated with the von Willebrand factor-cleavage activity under fluid shear stress.. ...
ADAMTS4 antibody (ADAM metallopeptidase with thrombospondin type 1 motif 4) for IHC-P, WB. Anti-ADAMTS4 pAb (GTX55492) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Adam Smith Economist Giclee Print by William Holl the Younger. lot title economist at advance? 8 Discover Adam Smith due and complex employees. How is an cutting be Adam Smith and our day at Augsburg? eclipse Statue Of Economist Adam Smith Unveiled At Edinburghs Royal Mile entire cells. culture: an sector to Adam Smith. Adam Smith, common ebook maternal and infant scarce newsletter and Access. But it attracts already been the Rome of the North. 1-1158911 IT publishes the high ebook maternal and infant where one of Scotlands greatest experiments realised his medieval descriptions. detail of Adam Smith is. Adam Smith & Canadian Economics. How the way planned Its web! How Adam Smith Can reevaluate Your ebook maternal and infant assessment for breastfeeding and. Economic Concepts Economist John Maynard Keynes is supported, only with Adam Smith and a herbal scholarly types, with using top notes. 25 pulses The streptozotocin ebook maternal and infant assessment for, Adam Smith, was The Wealth of ...
Compare ADAM metallopeptidase with thrombospondin type 1 motif 15 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Abstract. Neutralising inhibitors against ADAMTS-13 are detected in 51-67% of patients with Thrombotic Thrombocytopenic Purpura (TTP). These ADAMTS-13 inhibitor
I'm with you, Lanie, I say embrace him as an evil bad-ass wannabe son of a bastard and quit trying to whitewash his actions as though he's some sort of marter. He burned up Ashley's baby (just like he burned up Delia's scarf), kidnapped Faith, slept with the mother of the baby he'd kidnapped to get back at his brother. He has a harverd education; one could say that Nick and Victoria never went to university or anything and had everything handed to them, which I believe is true. However, to justify Adam's actions by saying that they were mean to poor ruthless evil Adam? And using Victor's abandonment as an excuse to justify his behaviour? Well, Victor was left at an orphanage, while Cliff and Hope raised Adam in a loving environment. If Adam gets a pass, why not Victor? He's like Stafano on DOOL imho...I say embrace his villianness, especially when he's not showing any sign of changing...I mean, burning Delia's scarf like she was a piece of ...
John Allan Stewart Adams is considered to be one of the founding fathers of the Department of Geology at Rice University. Adams attended the University of Chicago where he obtained four degrees (B.S., M.S., Ph. B., and Ph.D.) from the Department of Geology and he also received a Fulbright grant to study in Norway for two years. While at the University of Chicago, he was a two time All-American cross-country runner. Adams joined the Rice faculty as an associate professor of Geology and then became Chairman of the Department, served as a professor for thirty-four years, and was very popular with faculty and students. Adams produced numerous publications and garnered many awards and honors. He also served as: Principal Investigator on Lunar Samples, President of the Houston Philosophical Society, American Executive Editor of Geochimica et Cosmochimica Acta, Councilman of the Geochemical Society, and consultant to Shell Development Company.. Return to the Table of Contents. ...
Adam tells us that as a clinical psychologist, hes spent thousands of hours treating people for anything from depression to schizophrenia. Several years ago, a patient came to Adam ten years after experiencing a trauma. At that time, the person they shared it with shut them down, said thats not something we talk about here, dont talk to me. This experience kept that person away from healthcare for 10 years. What might it have meant to support that person a decade earlier?. American Healthcare in Context. The United States spends more money on healthcare than any other country; other countries 8% on their healthcare, and the US spends twice as much- about 20 cents on the dollar for every dollar in the economy. Are we getting the value we need for that? Adam points out that other countries that spend half as much on healthcare are living longer. Why might that be? In the US, planning and delivery is hard. Adam cites a study noting that peoples needs vary widely over time.. In the US, 60% of ...
"ADAM family proteins in the immune system". Immunology Today. 20 (6): 278-84. doi:10.1016/S0167-5699(99)01464-4. PMID 10354553 ... "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8". Yamamoto S, Higuchi Y, Yoshiyama K, Shimizu E, Kataoka M, Hijiya N, ... The protein encoded by this gene may be involved in cell adhesion during neurodegeneration. Cluster of differentiation GRCh38: ... A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene. This ...
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family ... Primakoff P, Myles DG (2000). "The ADAM gene family: surface proteins with adhesion and protease activity". Trends Genet. 16 (2 ... It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein ... 2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed ...
ADAM Protein Evolution of snake venom McLane MA, Sanchez EE, Wong A, Paquette-Straub C, Perez JC (2004). "Disintegrins". Curr ... ADAM and ADAMTS protein families, which include important protease enzymes. The secreted protease ADAMTS13, found in serum, ... Disintegrin-like proteins are found in various species ranging from slime mold to humans. Some other proteins known to contain ... ADAM2 (beta-fertilin, the beta-subunit of guinea pig sperm surface protein PH30). PH30 is a protein involved in sperm-egg ...
"Structure-function analysis of the ADAM family of diintegrin-like and metalloproteinase-containing proteins". J. Protein Chem. ... The ADAM family of proteases is receiving increased attention for their ability to alter the balance between pro-and anti- ... Native proteins which contain such domains with regulatory activity are normally inactive, most likely because they are cryptic ... Most disintegrins contain this conserved RGD motif, but ADAM15 is the only member of the ADAM family to contain this motif. A ...
The ADAM-Integrin-Tetraspanin complexes, which is a family of proteins, also mediate gonocyte migration. These complexes ... The activation of protein kinase C by phorbol ester PMA also decreased fetal gonocyte mitotic activity. There are a number of ... These proteins specify embryonic cells into PGCs expressing the genes PRDM1 and PRDM14 at embryonic day (E) 6.25. The PGCs ... Tres, Laura L.; Kierszenbaum, Abraham L. (2005). "The ADAM-integrin-tetraspanin complex in fetal and postnatal testicular cords ...
The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript ... "Entrez Gene: ADAM28 ADAM metallopeptidase domain 28". Roberts CM, Tani PH, Bridges LC, et al. (1999). "MDC-L, a novel ... This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane- ... Disintegrin and metalloproteinase domain-containing protein 28 is an enzyme that in humans is encoded by the ADAM28 gene. ...
2003). "Expression of ADAM-9 mRNA and protein in human breast cancer". Int. J. Cancer. 105 (6): 754-61. doi:10.1002/ijc.11161. ... The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, ... 2003). "ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts". ... "Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma)". Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence ...
Many sheddases are members of the ADAM or aspartic protease (BACE) protein families. These enzymes can activate a transmembrane ... protein if it is a receptor (e.g., HER2), or cut off the part of the transmembrane protein which has already bound an agonist ( ... Tumor necrosis factor alpha converting enzyme (TACE) is a sheddase protein that has been observed in many types of cancer and ... Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ...
Cluster of differentiation ADAM 17 Metallopeptidase ADAM Protein GRCh38: Ensembl release 89: ENSG00000137845 - Ensembl, May ... Members of the ADAM family are cell surface proteins with a unique structure, possessing both potential adhesion and protease ... This gene encodes an ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. ADAM10 (EC#: 3.4.24.81) ... ADAM10 belongs to subfamily A, the most ancestral subfamily of ADAM proteins, which is shared by all major groups of animals, ...
ADAM 12, a metalloprotease that binds insulin growth factor binding protein-3 (IGFBP-3), appears to be an effective early Down ... This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane- ... Decreased levels of ADAM 12 may be detected in cases of trisomy 21 as early as 8 to 10 weeks gestation. Maternal serum ADAM 12 ... Loechel F, Fox JW, Murphy G, Albrechtsen R, Wewer UM (Nov 2000). "ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by ...
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane- ... "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11". Wolfsberg TG, Primakoff P, Myles DG, White JM (1995). "ADAM, a novel ... Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene. ... Sagane K, Ohya Y, Hasegawa Y, Tanaka I (1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3 ...
Zoologists, such as Adam Britton, believe that such a diet containing protein is unhealthy for the animal's digestive system ... ISBN 0-671-47654-8. Britton, Adam (April 19, 2007). "Animal Protein and Claw Trimming". Melissa Kaplan's Herp Care Collection. ... A protein or lettuce diet will greatly shorten the Iguana's life and for this reason should be avoided. Being tropical animals ... There is some debate as to whether captive green iguanas should be fed animal protein. ...
Britton, Adam (2007-04-19). "Animal Protein and Claw Trimming". Melissa Kaplan's Herp Care Collection. Retrieved 2007-06-27.. ... such as Adam Britton, believe that such a diet containing protein is unhealthy for the animal's digestive system resulting in ... There is some debate as to whether captive green iguanas should be fed animal protein.[7] There is evidence of wild iguanas ... Although green iguanas in captivity will eat meat if presented with it, excessive consumption of animal protein results in ...
Finn, Adam (1 January 2004). "Bacterial polysaccharide-protein conjugate vaccines". British Medical Bulletin. 70 (1): 1-14. doi ... mutant diphtheria protein; and meningococcal group B outer membrane protein. Multiple combinations of Hib and other vaccines ... PRP covalently linked to a protein carrier was found to elicit a greater immune response than the polysaccharide form of the ... The CDC and the WHO recommend that all infants be vaccinated using a polysaccharide-protein conjugate Hib vaccine, starting ...
ADAM-like, decysin 1 is a protein that in humans is encoded by the ADAMDEC1 gene. This encoded protein is thought to be a ... This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [ ... Fritsche, J; Müller, A; Hausmann, M; Rogler, G; Andreesen, R; Kreutz, M (2003). "Inverse regulation of the ADAM-family members ... provided by RefSeq, Jul 2008]. "Entrez Gene: ADAM-like, decysin 1". Retrieved 2014-08-16. CS1 maint: discouraged parameter ( ...
Friedberg, Iddo; Martin Jambon; Adam Godzik (June 2006). "New avenues in protein function prediction". Protein Science. 15 (6 ... There are several computational methods of protein function prediction that can infer protein function using a variety of ... Of those 48,000 proteins, 866 were experimentally annotated during target accumulation phase. The results showed that current ... The process of experimentally determining the role of a protein in the cell, is an expensive and time consuming task. Further, ...
Wolfsberg, TG (1995). "ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a ... This membrane protein is critical for crucial steps in fertilization such as migration of sperm through the uterus to the ... A disintegrin and metalloprotease 3, or ADAM3, belongs to a family of peptidase proteins referred to as ADAMs. Many of these ... Fujihara, Y (2014). "GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male ...
Other ADAM proteins, ADAM17 (also called TACE, tumor necrosis factor-α converting enzyme), ADAM9, and ADAM19 have also been ... have also been implicated in similar maturation events for other transmembrane proteins such as MHC class I proteins. Recent ... "Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the ... Several such proteins, notably ADAM10, have been identified as possessing alpha-secretase activity. Upon cleavage by alpha ...
... is an 85-kDa enzyme that is a member of the transmembrane ADAM (A Disintegrin and Metalloprotease) protein family. ... ADAM7 is also denoted as: ADAM_7, ADAM-7, EAPI, GP-83, and GP83. The functions of ADAM7 directly relate to sperm maturation and ... Disintegrin and metalloproteinase domain-containing protein 7 is a protein that in humans is encoded by the ADAM7 gene. ... Lacking protease activity, ADAM7 may play roles in protein-protein interactions and cell adhesion processes including sperm-egg ...
ADAM metallopeptidase with thrombospondin type 1 motif 6 is a protein that in humans is encoded by the ADAMTS6 gene. This gene ... "Entrez Gene: ADAM metallopeptidase with thrombospondin type 1 motif 6". Retrieved 2017-09-01. Jorgenson, E.; Makki, N.; Shen, L ... Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a ... encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ...
"Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for ... immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal ... "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)". Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon- ... This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane- ...
ADAM metallopeptidase with thrombospondin type 1 motif, 17 is a protein that in humans is encoded by the ADAMTS17 gene. This ... The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The ... "Entrez Gene: ADAM metallopeptidase with thrombospondin type 1 motif, 17". Shah MH, Bhat V, Shetty JS, Kumar A (2014). "Whole ... ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a ...
The Notch protein spans the cell membrane, with part of it inside and part outside. Ligand proteins binding to the ... Palomero, Teresa; Lim, Wei Keat; Odom, Duncan T.; Sulis, Maria Luisa; Real, Pedro J.; Margolin, Adam; Barnes, Kelly C.; O'Neil ... Other proteins also participate in the intracellular portion of the notch signaling cascade. Notch signaling is initiated when ... In the nematode C. elegans, two genes encode homologous proteins, glp-1 and lin-12. There has been at least one report that ...
They inhibit protein synthesis by binding reversibly to the bacterial 30S ribosomal subunit and preventing the aminoacyl tRNA ... Warburton, Philip J.; Amodeo, Nina; Roberts, Adam P. (December 2016). "Mosaic tetracycline resistance genes encoding ribosomal ... Tetracyclines inhibit protein synthesis in both bacterial and human cells. Bacteria have a system that allows tetracyclines to ... This ultimately prevents protein synthesis and thus inhibiting bacterial growth. However, the addition of an N,N,- ...
Pinnacle Foods to buy Canadian protein foods maker Garden. Reuters, 14 November 2014 Bednar, Adam. "Pinnacle coming to ... In 2007, Garden Protein had 85 employees and had $50 million in yearly sales. In 2014, they had nearly $100 million in yearly ... Garden Protein International was established by former chef Yves Potvin. In 2001, Potvin sold his company, Yves Veggie Gourmet ... Gardein (a portmanteau of garden and protein) is a product line of meat-free foods made by Conagra Brands in Richmond, British ...
Dreyfuss, G.; Choi, Y. D.; Adam, S. A. (1984). "Characterization of heterogeneous nuclear RNA-protein complexes in vivo with ... and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013-1021. doi:10.1016/S0092- ... a Novel WD Repeat Protein Component of the SMN Complex That Binds Sm Proteins". Journal of Biological Chemistry. 277 (7): 5631- ... A primary research goal of the lab is to elucidate the function of Survival of Motor Neuron protein, SMN, which assembles a ...
Gillespie, Adam W., et al. "Glomalin-related soil protein contains non-mycorrhizal-related heat-stable proteins, lipids and ... Proteomic work has revealed that most of the proteins isolated in the glomalin extraction are not of mycorrhizal origin, and ... and that aggregate formation may be mediated by the arbuscular mycorrhizal protein glomalin. Therefore, even if glomalin itself ...
The third, Adam, was close to death. Hepburn's limbs began to swell with protein deficiency oedema. Finally, on 7 November, ... The voyageurs, led by the two interpreters Pierre St Germain and Jean Baptiste Adam, rebelled. Franklin's threats were ... ineffective; St Germian and Adam insisting that as continuing into the wilderness would mean certain death, the threat of ...
They also work as sites for protein-protein interactions, and can even play a role in the assembly of protein complexes. ... Gregory A, Kurian MA, Haack T, Hayflick SJ, Hogarth P (1993). Adam MP, Ardinger HH, Pagon RA, Wallace SE (eds.). Beta-Propeller ... The influenza virus protein viral neuraminidase is a six-bladed beta-propeller protein whose active form is a tetramer. It is ... Due to its structure and plasticity, protein-protein interactions can form with the top, bottom, central channel, and side ...
Shai, Adam; Larkum, Matthew Evan (2017-12-05). "Branching into brains". eLife. 6. doi:10.7554/eLife.33066. ISSN 2050-084X.. ... proteins, and chemical coupling to network oscillations, columnar and topographic architecture, and learning and memory. ...
Purcell, Adam (16 January 2016). "Leaves". Basic Biology. Adam Purcell. Retrieved 17 February 2017.. ... The concentration of photosynthetic structures in leaves requires that they be richer in protein, minerals, and sugars than, ... Runions, Adam; Fuhrer, Martin; Lane, Brendan; Federl, Pavol; Rolland-Lagan, Anne-Gaëlle; Prusinkiewicz, Przemyslaw (1 January ... further processed by chemical synthesis into more complex organic molecules such as proteins or cellulose, the basic structural ...
... which code for proteins with antiviral properties.[51] EBOV's V24 protein blocks the production of these antiviral proteins by ... Fink, Sheri; Adam Nossiter; James Kanter (10 October 2014). "Doctors Without Borders Evolves as It Forms the Vanguard in Ebola ... which are then translated into structural and nonstructural proteins. The most abundant protein produced is the nucleoprotein, ... EBOV replication overwhelms protein synthesis of infected cells and the host immune defences. The GP forms a trimeric complex, ...
This form of motility has been shown to be regulated by the cAMP receptor protein. Hedger 11:30, 14 2007. The mechanism for ... the nitrogen-fixing protein complex may be packaged into specialized cells called heterocysts." Aren't bacteria single-celled? ... However it is a somewhat ineffective method as it causes the organism to degrade protein, a very metabolically expensive method ...
Mijelin protein nula • Osteonektin • Protein C • Protein S • Proteoglikan • Serum amiloid P komponenta • Sialoglikoprotein ( ... Aktivin i inhibin • ADAM • Alfa 1-antihimotripsin • Apolipoprotein H • CD70 • Asijaloglikoprotein • Avidin • B-ćelijski ... Faktor aktivacije B-ćelija, (BAFF) koji je takođe poznat kao faktor nekroze tumora ligand superfamilija član 13B, je protein ... On je izražen kao transmembranski protein na različitim ćelijskim tipovima, kao što su monociti, dendritske ćelije i ćelije ...
Masculine secondary sexual characteristics include androgenic hair, voice deepening, emergence of the Adam's apple, broadening ... "G protein-coupled receptors: extranuclear mediators for the non-genomic actions of steroids". Int J Mol Sci. 15 (9): 15412-25 ...
Mutations in the RPS6KA3 disturb the function of the protein, but it is unclear how a lack of this protein causes the signs and ... In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews [Internet]. Seattle, Washington: University of Washington, ... The RPS6KA3 gene makes a protein that is involved with signaling within cells. Researchers believe that this protein helps ... The protein RSK2 which is encoded by the RPS6KA3 gene is a kinase which phosphorylates some substrates like CREB and histone H3 ...
AR NTD antagonists bind covalently to the NTD of the AR and prevent protein-protein interactions subsequent to activation that ... Winsor Bowsher; Adam Carter (15 April 2008). Challenges in Prostate Cancer. John Wiley & Sons. pp. 138-. ISBN 978-1-4051-7177-9 ... Blood proteinsEdit. In addition to their antigonadotropic effects, estrogens are also functional antiandrogens by decreasing ... cortisol binding to plasma proteins". J. Steroid Biochem. 33 (2): 251-5. doi:10.1016/0022-4731(89)90301-4. PMID 2788775.. ...
a b c Broad 1989b, Goodstein 1994, Platt 1998, Voss 1999, Beaudette 2002, Feder 2005, Adam 2005 "Advocates insist that there is ... It was adopted as a software product name Adobe ColdFusion and a brand of protein bars (Cold Fusion Foods).[182] It has also ... Adam, David (24 March 2005), Rusbringer, Alan, ed., "In from the cold", The Guardian, London, retrieved 25 May 2008. ... 2006, Adam 2005 ("[Absolutely not]. Anyone can deliver a paper. We defend the openness of science" - Bob Park of APS, when ...
The term alpha-1 refers to the protein's behavior on protein electrophoresis. On electrophoresis, the protein component of the ... Campos, Michael A.; Alazemi, Saleh; Zhang, Guoyan; Wanner, Adam; Sandhaus, Robert A. (2009-02-01). "Effects of a disease ... which could confer this protein particular protein-cell recognition properties. The single cysteine residue of A1AT in position ... As protein electrophoresis is imprecise, the A1AT phenotype is analysed by isoelectric focusing (IEF) in the pH range 4.5-5.5, ...
The albumin (9) further protects the embryo and serves as a reservoir for water and protein. The allantois (8) is a sac that ... a serpent appears in Genesis to tempt Adam and Eve with the forbidden fruit from the Tree of Knowledge of Good and Evil.[141] ... The yolk sac (2) surrounding the yolk (3) contains protein and fat rich nutrients that are absorbed by the embryo via vessels ( ... "Sister group relationship of turtles to the bird-crocodilian clade revealed by nuclear DNA-coded proteins". Molecular Biology ...
Adam Smith * sw:Adam Smith. Addiction * sw:Uraibu. Adolf Hitler * sw:Adolf Hitler. Afghanistan * sw:Afghanistan. Africa * sw: ... Protein * sw:Protein. Protestant Reformation * sw:Protestant Reformation. Protist * sw:Protist. Psychology * sw:Psychology. ...
Required for many proteins and enzymes, notably hemoglobin to prevent anemia Meat, seafood, nuts, beans, dark chocolate[23] ... Adam Drewnowski (2010). "The Nutrient Rich Foods Index helps to identify healthy, affordable foods" (PDF). The American Journal ...
低碳水化合物饮食:指增加食物中脂肪或脂肪和蛋白质的比例,比如Atkins减肥法和高蛋白质饮食法(英语:High-protein diet)。这种方法非常流行,但腎功能略差就不適用(許多人腎功能稍差,但他們沒有任何症狀),且此方法也不为美国心脏协会所推荐。 ... Darvall KA, Sam RC, Silverman SH, Bradbury AW, Adam DJ.
... who believed that transcription was activated by protein-DNA and protein-protein interactions on largely naked DNA templates, ... Guillemette B, Bataille AR, Gévry N, Adam M, Blanchette M, Robert F, Gaudreau L (Dec 2005). "Variant histone H2A.Z is globally ... Nuclear protein Ataxia-Telangiectasia (NPAT), also known as nuclear protein coactivator of histone transcription, is a ... The first step of chromatin structure duplication is the synthesis of histone proteins: H1, H2A, H2B, H3, H4. These proteins ...
Sathyapalan T, Atkin SL. Mediators of inflammation in polycystic ovary syndrome in relation to adiposity. Mediators Inflamm. ... Kelly CJ, Stenton SR, Lashen H. Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis. ...
Sterol Regulatory Element Binding Protein 1 and 2).[10] In the presence of cholesterol, SREBP is bound to two other proteins: ... Ulmer H., Kelleher C., Diem G., Concin H. (2004). "Why Eve is not Adam: prospective follow-up in 149650 women and men of ... The main regulatory mechanism is the sensing of intracellular cholesterol in the endoplasmic reticulum by the protein SREBP ( ... In order to carry large quantities of cholesterol it is transported in the bloodstream by lipoproteins-protein "molecular- ...
This protein is associated with the primary cilia of the retinal pigment epithelial cells, fibroblasts and kidney tubular cells ... Lewis, Richard Alan; Nussbaum, Robert L.; Brewer, Eileen D. (1993-01-01). Pagon, Roberta A.; Adam, Margaret P.; Ardinger, Holly ...
Neil Kensington Adam summarized and expanded on the work of Langmuir in a series of several papers published in Proceedings of ... ranging from 2D crystallization of proteins to Brewster angle microscopy. The LB trough's general objective is to study the ... Adam, N. K. (1921). The properties and molecular structure of thin films of palmitic acid on water. Part I. Proceedings of the ...
positive regulation of non-membrane spanning protein tyrosine kinase activity. • transmembrane receptor protein tyrosine kinase ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... Brain-derived neurotrophic factor (BDNF), or abrineurin,[5] is a protein[6] that, in humans, is encoded by the BDNF gene.[7][8] ... GO:0001948 protein binding. Cellular component. • cytoplasm. • perinuclear region of cytoplasm. • mitochondrion. • nuclear ...
Addy M. Dentine Hypersensitivity. New perspectives on an old problem. Int Dent J (2002) 52; 367-375. ... which includes dentine-specific proteins), and 10% water (which is adsorbed on the surface of the minerals or between the ...
The resulting BLM protein is defective. the defect in RecQ an helicase facilitates the defective unwinding of DNA during ... Sanz, Maureen M.; German, James; Cunniff, Christopher (11 March 1993). Adam, Margaret P.; Ardinger, Holly H.; Pagon, Roberta A ... commonly the green fluorescent protein or GFP) and an allele of a gene to be studied (both on chromosomes bearing FRT sites). ...
Nicholas J. Robert, Véronique Diéras, John Glaspy, Adam M. Brufsky, Igor Bondarenko, Oleg N. Lipatov, Edith A. Perez, Denise A ...
The rearing of one larva requires 125-187.5 mg pollen or 25-37.5 mg protein for proper development.[31] Dietary proteins are ... Adam, Brother. In Search of the Best Strains of Bees. Hebden Bridge, W. Yorks: Northern Bee Books, 1983. ... Adult worker honey bees consume 3.4-4.3 mg of pollen per day to meet a dry matter requirement of 66-74% protein.[31] ... Adam, Brother. Bee-keeping at Buckfast Abbey. Geddington, Northants: British Bee Publications, 1975. ...
Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul. Gray's anatomy for ... 蛋白質(英语:Template:Nerve tissue protein). *神經遞質 ...
Rudwick, Martin J.S. (2008). Worlds Before Adam: The Reconstruction of Geohistory in the Age of Reform. The University of ... by comparing sequences of DNA or proteins. The result of a successful analysis is a hierarchy of clades - groups that share a ... Although this early study compared proteins from apes and humans, most molecular phylogenetics research is now based on ...
High-protein diets may also be associated with increased risk for coronary heart disease due to intakes of saturated fat, ... in accord with the promise of the Atkin's diet: a "high calorie way to stay thin forever."[19] ... St Jeor ST, Howard BV, Prewitt TE, Bovee V, Bazzarre T, Eckel RH (October 2001). "Dietary protein and weight reduction: a ... The American Kidney Fund: American Kidney Fund Warns About Impact of High-Protein Diets on Kidney Health: 25 April 2002 ...
Saliva also contains a glycoprotein called haptocorrin which is a binding protein to vitamin B12.[17] It binds with the vitamin ... Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2005). Gray's anatomy ... It also maintains protein metabolism in its synthesis and degradation. In lipid metabolism it synthesises cholesterol. Fats are ... The taste of umami is thought to signal protein-rich food. Sour tastes are acidic which is often found in bad food. The brain ...
"Adam Melonas's Progressive cuisine Blog". Madrid Lab. Retrieved 2012-02-16.. *^ Husband, Stuart (2 August 2012). "What next for ... the digestion of protein by fresh pineapple juice, and a reverse baked alaska-hot inside, cold outside-cooked in a microwave ... Adam Melonas's signature preparation is an edible floral center piece named the "Octopop": a very low temperature cooked ... Adam Melonas, Kevin Sousa, and Laurent Gras.[citation needed] ... Transglutaminase - a protein binder, called meat glue. * ...
positive regulation of non-membrane spanning protein tyrosine kinase activity. • transmembrane receptor protein tyrosine kinase ... Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... Brain-derived neurotrophic factor, also known as BDNF, is a protein[5] that, in humans, is encoded by the BDNF gene.[6][7] BDNF ... Neurotrophins are proteins that help to stimulate and control neurogenesis, BDNF being one of the most active.[13][14][15] Mice ...
ADAM22 ADAM metallopeptidase domain 22". "Entrez Gene: ADAM23 ADAM metallopeptidase domain 23". "Entrez Gene: ADAM28 ADAM ... ADAM metallopeptidase domain 7". "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8". "Entrez Gene: ADAM9 ADAM metallopeptidase ... Most green algae and all land plants likely lost ADAM proteins. ADAMs are categorized under the EC 3.4.24.46 enzyme group, and ... 1995). "ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and ...
Adam protein (A Disintegrin and Metalloproteinase Protein) is a family of peptidase proteins[1]. ADAMs are also known as the ... For example, ADAM 10 can cut off part of the HER2 receptor, activating it[2] and ADAM 17 can cut off part of the EGFR once it ... 1995). "ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and ... ADAM+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Pfam protein domain database. More...Pfami. View protein in Pfam. PF08516, ADAM_CR, 1 hit. PF00200, Disintegrin, 1 hit. ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS50215, ADAM_MEPRO, 1 hit. PS00427 ... to allow unambiguous identification of a protein.,p>,a href=/help/protein_names target=_top>More...,/a>,/p>Protein namesi. ... View protein in Pfam. PF08516, ADAM_CR, 1 hit. PF00200, Disintegrin, 1 hit. PF01562, Pep_M12B_propep, 1 hit. PF01421, ...
It can also be mentioned to help with grams of protein per kilogram of body. ... for tics Matrix products price in india Testosterone propionate trenbolone cycle Testosterone booster supplements uk Protein ...
Pfam protein domain database. More...Pfami. View protein in Pfam. PF17771 ADAM_CR_2, 1 hit. PF05986 ADAM_spacer1, 1 hit. ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS50215 ADAM_MEPRO, 1 hit. PS50092 ... View protein in Pfam. PF17771 ADAM_CR_2, 1 hit. PF05986 ADAM_spacer1, 1 hit. PF01562 Pep_M12B_propep, 1 hit. PF01421 ... View protein in InterPro. IPR041645 ADAM_CR_2. IPR010294 ADAM_spacer1. IPR013273 ADAMTS/ADAMTS-like. IPR024079 MetalloPept_cat_ ...
... atkin diet results, a healthy meal plan for weight loss ... Atkin diet results,source of nutrients,how do you lose weight ...
Full nutritional breakdown of the calories in Adams Organic French Onion Soup based on the calories and nutrition in each ... Calories in Adams Organic French Onion Soup. View the full Adams Organic French Onion Soup Recipe & Instructions. Submitted ... Calories per serving of Adams Organic French Onion Soup. 36 calories of Earth Balance Natural Buttery Spread, (0.36 tbsp). 29 ...
Cleavage of CD23 by ADAM proteins is regulated by beta-2 adrenergic receptor engagement on primed B cells (55.11). Caroline ... Cleavage of CD23 by ADAM proteins is regulated by beta-2 adrenergic receptor engagement on primed B cells (55.11) ... Cleavage of CD23 by ADAM proteins is regulated by beta-2 adrenergic receptor engagement on primed B cells (55.11) ... Cleavage of CD23 by ADAM proteins is regulated by beta-2 adrenergic receptor engagement on primed B cells (55.11) ...
... modular architecture of ADAM/adamalysin/reprolysin family proteins.. Igarashi T1, Araki S, Mori H, Takeda S. ... ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different ... modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins. ... Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing ...
Study 2 demonstrated that regardless of protein type (hemp, dairy milk or whey protein isolate) post training session CHO- ... Six weeks of concurrent training, when supplemented with hemp based protein-CHO drink post exercise, appears to be effective at ... Thus, post training session CHO-protein ingestion appears to be as effective for strength development over 10 weeks of training ... However, debate exists about whether the type of protein consumed, animal vs plant, affects exercise performance differently. ...
Eve-1, an ADAM adaptor protein reported to be essential for PKC-regulated shedding of pro-EGF, was found to play no obvious ... compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such as Munc13-1. We have ... Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular ... Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, ...
A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins ... A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins. PLoS ONE, 6 (3). e18142. ISSN 1932- ...
ADAM 4, and ADAM 5. Fertilin α, ADAM 4, and ADAM 5 are expressed in testis and other tissues, whereas fertilin β and cyritestin ... This protein family has been named ADAM because all members contain a disintegrin and metalloprotease domain. Previous studies ... Five members of the ADAM protein family, all of which are expressed in testis, have been sequenced in mouse (Heinlein et al., ... Fertilin α and β are the first identified members of a new family of membrane proteins, the ADAM family (a disintegrin and ...
"ADAM Proteins" by people in this website by year, and whether "ADAM Proteins" was a major or minor topic of these publications ... "ADAM Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "ADAM Proteins" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "ADAM Proteins". ...
The NIPBL protein is quite large; so seven subdomain regions were cloned and expressed. GST-tagged MLL repression domain was ... protein serves as a positive transcriptional regulator during hematopoietic and embryonic development. The MLL gene can undergo ... Marek, Adam Robert, "Determination of An Interaction between Nipped B-Like Protein and MLL" (2012). Masters Theses. 825. https ... The NIPBL protein is quite large; so seven subdomain regions were cloned and expressed. GST-tagged MLL repression domain was ...
... networks of proteins must work together. It is now clear that the protein machines that control such processes in cells are ... In fact, research into the complex protein machinery that controls cell adhesion is revealing much more about the biology of ... These proteins regulate the expression of chemokine genes, for example, which encode signalling proteins that are released by ... The multi-protein adhesion complexes that form when integrin adhesion receptors bind to extracellular proteins consist of ...
Hughes, Adam / University of Utah. NIH 2015. R00 AG. Role of Mitophagy in Mitochondrial Protein Quality Control. Hughes, Adam ... Role of Mitophagy in Mitochondrial Protein Quality Control Hughes, Adam University of Utah, Salt Lake City, UT, United States ... Role of Mitophagy in Mitochondrial Protein Quality Control. Hughes, Adam / University of Utah. $249,000. ... Rutter, Jared; Hughes, Adam L (2015) Power(2): the power of yeast genetics applied to the powerhouse of the cell. Trends ...
Chocolate Covered Almond Protein Balls…HELL YEAH!!. by Adam Stansbury , July 18, 2017 , Nutrition, Protein, Recipe, Vegan ... Creating Protein Packed Plant Powered Recipes. by Adam Stansbury , September 22, 2017 , Education, Nutrition, Protein, Vegan ... Sources of Plant Based Proteins. by Adam Stansbury , September 22, 2017 , Education, From Meat to Plants, Nutrition, Protein, ... The Protein Myth. by Adam Stansbury , August 18, 2017 , Education, Nutrition, Protein, Vegan ...
The Protein Myth. by Adam Stansbury , August 18, 2017 , Education, Nutrition, Protein, Vegan , 0 comments ... Saying all that, protein is of course essential but not to the degree we think it is and your protein intake should always be ... We over consume animal protein in western countries and have now added additional protein into nearly every form of food group ... "But where do you get your protein from?". The age old annoying question posed by meat eaters to anyone adopting a vegan plant ...
... mitochondrial potassium channels and uncoupling proteins. Despite the molecular differences between these proteins both of them ... Understanding the role of these proteins, especially in the context of ischemia-reperfusion injury of cardiac muscle, may be ... This review highlights several aspects of the regulation of mitochondrial potassium channels and uncoupling proteins in muscle ... and uncoupling proteins may be regulated in a similar manner suggesting that both are part of the energy-dissipating hub in ...
Plant-based Protein Leader Greenleaf Foods, SPC, Names Adam Grogan Chief Operating Officer. CHICAGO, Aug. 27, 2019 /PRNewswire ... Plant-based protein leader Greenleaf Foods, SPC, today named Adam Grogan Chief Operating Officer effective September 9, 2019. ...
Protein Content and Amino Acid Composition of Commercially Available Plant-based Protein Isolates. The referenced article can ...
p,Arabidopsis thaliana contains two nuclear XRN2/3 5′-3′ exonucleases that are homologs of yeast and human Rat1/Xrn2 proteins ... Knowledge base: Adam Mickiewicz University * Skip to main menu * Skip to main content ... Defective XRN3-mediated transcription termination in Arabidopsis affects the expression of protein-coding genes. Authors:. * ... Arabidopsis thaliana contains two nuclear XRN2/3 5′-3′ exonucleases that are homologs of yeast and human Rat1/Xrn2 proteins ...
Eve-1, an ADAM adaptor protein reported to be essential for PKC-regulated shedding of pro-EGF, was found to play no obvious ... compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such as Munc13-1. We have ... Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular ... Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, ...
A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. PLoS One. 2011 Mar 29;6(3). e18142 ... A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. / Leonardi, Emanuela; Andreazza, ... title = "A computational model of the LGI1 protein suggests a common binding site for ADAM proteins", ... T1 - A computational model of the LGI1 protein suggests a common binding site for ADAM proteins ...
ADAM Proteins * Metalloendopeptidases * ADAM17 Protein * ADAM17 protein, human ...
Proto-Oncogene Proteins c-akt * Extracellular Signal-Regulated MAP Kinases * ADAM Proteins ...
ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview. ... A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease. ... Emerging roles of ADAM and ADAMTS metalloproteinases in cancer.. Rocks N, Paulissen G, El Hour M, Quesada F, Crahay C, Gueders ... Role of ADAM and ADAMTS metalloproteinases in airway diseases.. Paulissen G, Rocks N, Gueders MM, Crahay C, Quesada-Calvo F, ...
Protein trafficking (with Adam Byron). • Drug discovery and cancer pharmacology. Interested researchers are encouraged to ... They have also been invited to write topical reviews on trafficking of adhesion proteins and adhesion protein networks by ... contact Prof Margaret Frame ([email protected]), Prof Val Brunton ([email protected]) or Dr Adam Byron (adam[email protected] ... They have now been awarded substantial funding to explore adhesion protein networks in glioblastoma, a highly aggressive type ...
... and it has been hypothesized that homocysteinylated proteins are important mediators of the toxic effects of ... The cardiovascular risk factor homocysteine is mainly bound to proteins in human plasma, ... 0/Albumins; 0/CCL2 protein, human; 0/Chaperonin 60; 0/Chemokine CCL2; 454-28-4/Homocysteine; EC 3.4.24.-/ADAM Proteins; EC 3.4. ... ADAM Proteins / metabolism*. Albumins / chemistry, physiology*. Cell Adhesion. Cell Line. Chaperonin 60 / metabolism*. ...
  • Fertilin α and β are the first identified members of a new family of membrane proteins that each has the following domains: pro-, metalloprotease, disintegrin, cysteine-rich, EGF-like, transmembrane, and cytoplasmic domain. (rupress.org)
  • This protein family has been named ADAM because all members contain a disintegrin and metalloprotease domain. (rupress.org)
  • These sperm disintegrin-like proteins are members of a molecular family, known as ADAM's (for A Disintegrin and A Metalloprotease) or MDC's (for Metalloprotease, Disintegrin, Cysteine-rich). (bioscience.org)
  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. (genecards.org)
  • ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. (ebi.ac.uk)
  • The enzymes that are responsible for this process, which is called protein ectodomain shedding, are frequently members of the ADAM (a disintegrin and metalloprotease) family of membrane-anchored metalloproteases ( 1 , 2 ). (aacrjournals.org)
  • Two members of the ADAM (a disintegrin and metalloprotease)-family, MADDAM and decysin, were described as dendritic cell (DC) maturation markers. (uni-regensburg.de)
  • The secretases that cleave these membrane proteins share several properties including upregulation by phorbol esters and muscarinic agonists, and inhibition by hydroxamate-based zinc metalloprotease inhibitors such as batimastat. (biologists.org)
  • Nonetheless, not all human ADAMs have a functional protease domain, which indicates that their biological function mainly depends on protein-protein interactions. (wikipedia.org)
  • The networks of adhesion proteins and their interactions work to control the migration, proliferation and survival of cells. (adambyron.com)
  • In contrast to other genes involved in epileptic disorders, epitempin shows no homology with known ion channel genes but contains two domains, composed of repeated structural units, known to mediate protein-protein interactions. (hud.ac.uk)
  • This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. (genecards.org)
  • Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. (genecards.org)
  • Such interactions play a vital role in cellular processes, therefore studying networks of interacting proteins can give fundamental biological insights. (news-medical.net)
  • A myriad of methods have been developed and enhanced over the years for the investigation of protein-protein interactions. (news-medical.net)
  • Proteomics based on quantitative mass spectrometry combined with affinity purification protocols has become the method of choice to map and follow the dynamic changes in protein-protein interactions - including the ones occurring during cellular signaling events. (news-medical.net)
  • The structure and nature of protein interaction networks, which are pivotal to the proper functioning of the basic molecular mechanisms underlying cellular life, is best appreciated in biological networks as a part of complex system biology, particularly due to the rich datasets of protein interactions available for study. (news-medical.net)
  • Protein interaction networks can be created using protein interactions determined by any single or a combination of multiple experimental methods and data sets, where each protein is represented by a node, and two proteins are linked with each other if they have been shown to interact. (news-medical.net)
  • The yeast two-hybrid system (originally published in 1989) permits the profiling of protein interactions of any two proteins, which may be scaled up to cover the whole proteome of an organism. (news-medical.net)
  • This technique has been successfully applied to screen for protein-protein interactions of different eukaryotic species such as Saccharomyces cerevisiae , Caenorhabditis elegans , Drosophila melanogaster , as well as for a partial human interactome. (news-medical.net)
  • This strategy is employed to identify protein interactions under the physiological conditions within a cell. (news-medical.net)
  • For the identification of weak and ephemeral protein interactions, which are lost during the washing steps in normal purification protocols, chemical cross-linking approaches have been developed. (news-medical.net)
  • A paramount challenge in analyzing the large data sets is in the distinction of true protein interactions from the experimental noise that exists in the raw data obtained by a large-scale screening method. (news-medical.net)
  • This requires robust methods for the calculation of confidence scores for protein-protein interactions. (news-medical.net)
  • Retrieved on December 15, 2019 from https://www.news-medical.net/life-sciences/Protein-Protein-Interactions.aspx. (news-medical.net)
  • Investigation of the structure and function of cholesterol oxidase protein-membrane interactions, and its relationship to Mycobacterium tuberculosis pathogenesis. (stonybrook.edu)
  • Actin can sometimes form a complex with certain SUMO proteins, small proteins often attached to other proteins to alter their functions, their locations and their interactions with additional proteins. (news-medical.net)
  • The complexity of annotating and analyzing the function of proteins en masse has stimulated a variety of approaches, including maps of protein-protein ( 8 , 9 ) and protein-DNA ( 10 ) interactions, microarrays of spotted proteins ( 11 ), and genome-wide analysis of protein structure ( 12 ). (pnas.org)
  • Protein function can be regulated on many different levels, including spatial and temporal expression, posttranslational modifications, protein-protein interactions, and cofactor requirements. (pnas.org)
  • Virtually every aspect of the cellular processes in eukaryotes requires that the interactions between protein molecules are well coordinated in different regulatory pathways. (diva-portal.org)
  • Taken together, these studies substantially broaden our knowledge at a molecular level in protein interactions that are involved in transcriptional regulation and ubiquitination, studied by a carefully selected combination of complementary structural methods spanning different resolutions and time scales. (diva-portal.org)
  • Synthesis of peptides and polymers to probe the role of ADAM proteins in mammalian fertilization. (stonybrook.edu)
  • A method and apparatus for extracting, identifying, and manipulating proteins or peptides from a solution uses paramagnetic beads having a coating with an affinity for the target component. (google.ca)
  • In one embodiment, paramagnetic beads coated with C18 are used to adsorb proteins and peptides. (google.ca)
  • 2. The method of claim 1 , wherein said target component is a protein or peptide, and said coating on said beads has a binding affinity for proteins or peptides. (google.ca)
  • 4. The method of claim 2 , further comprising eluting said bound proteins or peptides from said beads. (google.ca)
  • cleaving said proteins or peptides from said beads. (google.ca)
  • ADAM17 (ADAM Metallopeptidase Domain 17) is a Protein Coding gene. (genecards.org)
  • A disintegrin and metallopeptidase domain 19 (meltrin beta), or ADAM metallopeptidase domain 19, is a human gene encoded by ADAM19. (biocompare.com)
  • ABSTRACT: BACKGROUND: Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such as Munc13-1. (jefferson.edu)
  • Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. (genecards.org)
  • Senile plaques are mainly composed of β-amyloid (Aβ) peptide which is generated by the anomalous endoproteolytic processing of the amyloid precursor protein (APP). (springer.com)
  • The metalloproteinase and major amyloid precursor protein (APP) α-secretase candidate ADAM10 is responsible for the shedding of proteins important for brain development, such as cadherins, ephrins, and Notch receptors. (jneurosci.org)
  • We investigated whether physiological concentrations of ET-1 enhance coronary smooth muscle contraction by activating a PKC-mediated signaling pathway involving tyrosine phosphorylation and activation of mitogen-activated protein kinase (MAPK). (ahajournals.org)
  • GRP can induce rapid phosphorylation of EGFR and p42/44 mitogen-activated protein kinase (MAPK) activation in part via extracellular release of transforming growth factor α (TGF-α) by matrix metalloproteinases (MMPs). (aacrjournals.org)
  • G proteins transduce signals from GPCRs to EGFR and mitogen-activated protein kinase (MAPK) via unknown intermediate molecules. (aacrjournals.org)
  • ADAM Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • ADAM genes are found in animals, choanoflagellates, fungi and some groups of green algae. (wikipedia.org)
  • These proteins regulate the expression of chemokine genes, for example, which encode signalling proteins that are released by cells into their surroundings. (adambyron.com)
  • Expression profiling and real time PCR, as well as protein analysis, showed an increase in the expression of genes encoding for chemokines/cytokines regulating the adhesion process and mediators of vascular remodeling (ADAM17, MCP1, and Hsp60). (biomedsearch.com)
  • these sites can be predicted by the surrounding amino acids, the basic building blocks of proteins whose blueprints are found in genes. (news-medical.net)
  • Compared to genes, proteins have been relatively understudied in human blood, even though they are the 'effectors' of human biology, are disrupted in many diseases, and are the targets of most medicines," says Dr Adam Butterworth from the Department of Public Health and Primary Care at the University of Cambridge, a senior author of the study. (cam.ac.uk)
  • Professor Metin Avkiran, Associate Medical Director at the British Heart Foundation, said: "Although our DNA provides our individual blueprint, it is the variations in the structure, function and amount of the proteins encoded by our genes which determine our susceptibility to disease and our response to medicines. (cam.ac.uk)
  • The first regulatory process studied here is the RNA polymerase-II mediated transcription of the eukaryotic protein-coding genes to produce mRNAs. (diva-portal.org)
  • Over the past two years, the Groups expanded their findings on this topic and provided important new insights on functions of other molecules regulating intracellular trafficking of cell adhesion proteins and/or cancer spread. (ed.ac.uk)
  • The molecules that will be discussed include three members of the ADAM/MDC family on sperm (fertilin alpha, fertilin beta, and cyritestin), integrins on eggs (alpha-6/beta-1 and others), and a number of other egg and sperm molecules, novel and characterized in other systems, that have been implicated in these processes. (bioscience.org)
  • When protein synthesis is taking place, enzymes link tRNA molecules to amino acids in a highly specific manner. (cliffsnotes.com)
  • There are also non-coding RNA molecules (ncRNAs), which are not directly involved in protein synthesis. (cliffsnotes.com)
  • Since no one can actually dock a billion virtual molecules into a protein target, how can we reduce the problem to something theoretically manageable without throwing away the answers we want? (sciencemag.org)
  • Cell adhesion is mediated by adhesion receptors , which are proteins on the surface of cells. (adambyron.com)
  • Adhesion receptors bind to the extracellular matrix - a complex mixture of proteins and sugars that surrounds cells, providing mechanical support and initiating biochemical signals in cells. (adambyron.com)
  • During cell adhesion, adhesion proteins inside cells are recruited to adhesion receptors to form multi-protein assemblies called adhesion complexes . (adambyron.com)
  • Recent research has uncovered wider roles for adhesion proteins away from adhesion receptors, and the second half of our article highlights the important functions of adhesion proteins in diverse subcellular locations. (adambyron.com)
  • The multi-protein adhesion complexes that form when integrin adhesion receptors bind to extracellular proteins consist of scaffolding, adaptor and signalling proteins. (adambyron.com)
  • This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. (genecards.org)
  • Several key components of the cell-to-cell signaling machinery, including all ligands of the epidermal growth factor receptor (EGFR) as well as other growth factors, cytokines, and their receptors, are synthesized as membrane-anchored proteins whose function can be modulated by proteolytic cleavage and release from the cell ( 1 ). (aacrjournals.org)
  • It has been reported that Src family kinases are activated by G-protein-coupled receptors (GPCRs), followed by downstream EGFR and MAPK activation. (aacrjournals.org)
  • Role of ADAM and ADAMTS metalloproteinases in airway diseases. (nih.gov)
  • Emerging roles of ADAM and ADAMTS metalloproteinases in cancer. (nih.gov)
  • ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview. (nih.gov)
  • Some ADAM proteins contain thrombospondin repeats and are known as ADAMTS proteins [ PMID: 9818177 , PMID: 7593158 ]. (ebi.ac.uk)
  • ADAMTS-1, an ADAM family member cloned from cachexigenic colon adenocarcinoma, is unusual in that it contains thrombospondin type I motifs and anchors to the extracellular matrix. (jci.org)
  • ADAMTS18 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. (antibodies-online.com)
  • This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. (abnova.com)
  • ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins . (wikidoc.org)
  • Those ADAMs which are active proteases are classified as sheddases because they cut off or shed extracellular portions of transmembrane proteins. (wikipedia.org)
  • They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain. (uchicago.edu)
  • These difficulties have largely been overcome with the development of biochemical methods to purify these adhesion proteins, as well as advances in ways to identify and quantify the proteins, using proteomics , and then to analyse the data computationally, using bioinformatics . (adambyron.com)
  • Quantification by proteomics of adhesion proteins during assembly and disassembly also revealed distinct patterns of protein recruitment, supporting and adding details to studies using microscopy. (adambyron.com)
  • Advanced proteomics technology - which can be applied to many tumor types - enables protein expression to be plotted on graphs that illustrate peaks and valleys. (medindia.net)
  • They also want to know if protein expression patterns found in the blood are expressed by cancer cells themselves, says Dr. Adam, who has begun doing proteomics studies on the cancerous tissue of surgery patients to find out. (medindia.net)
  • The key to a protein molecule is how the amino acids are linked. (cliffsnotes.com)
  • The sequence of amino acids in a protein is a type of code that specifies the protein and distinguishes one protein from another. (cliffsnotes.com)
  • For protein synthesis to occur, several essential materials must be present, such as a supply of the 20 amino acids, which comprise most proteins. (cliffsnotes.com)
  • They are the places (the chemical "workbenches") where amino acids are linked to one another to synthesize proteins. (cliffsnotes.com)
  • Transfer RNA exists in the cell cytoplasm and carries amino acids to the ribosomes for protein synthesis. (cliffsnotes.com)
  • A gene's DNA sequence reveals which amino acids will appear in the protein the gene encodes. (newscientist.com)
  • To guess a new protein's function, scientists often compare its amino acids with those of familiar proteins. (newscientist.com)
  • They then pick out amino acids that play important roles in other proteins, and decide where on this structure they lie. (newscientist.com)
  • Molecular chaperones mediate the correct folding and assembly of polypeptides, as well as repair damaged protein structures caused by stress, while proteases remove otherwise non-functional and potentially cytotoxic proteins. (diva-portal.org)
  • ADAM13 belongs to a group of proteins called proteases that cut other proteins to change their function. (umass.edu)
  • The adamalysin-like or ADAM family of metalloproteases (peptidase subfamily M12B) contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. (ebi.ac.uk)
  • After the first cleavage the heterodimeric receptor is able to interact with Notch ligands allowing a second (S2) cleavage within the Notch extracellular juxtamembrane region by ADAM proteases. (jneurosci.org)
  • Understanding the role of these proteins, especially in the context of ischemia-reperfusion injury of cardiac muscle, may be important for pharmacological intervention. (edu.pl)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • A method that combines the ability to monitor changes in the active state of enzymes as well as the abundance of the active enzymes would be particularly useful in dissecting intricate pathways and identifying relevant proteins involved in that pathway for use as drug targets or as diagnostic biomarkers. (pnas.org)
  • Any protein dysfunction involved in these regulatory pathways might lead to various pathological conditions. (diva-portal.org)
  • Our study reveals that ADAM10 plays a central role in the developing brain by controlling mainly Notch-dependent pathways but likely also by reducing surface shedding of other neuronal membrane proteins including APP. (jneurosci.org)
  • CHICAGO, Aug. 27, 2019 /PRNewswire/ - Plant-based protein leader Greenleaf Foods, SPC, today named Adam Grogan Chief Operating Officer effective September 9, 2019. (thestreet.com)
  • Systematic discovery of ectopic pregnancy serum biomarkers using 3-D protein profiling coupled with label-free quantitation. (biomedsearch.com)
  • A 3-D biomarker discovery strategy consisting of abundant protein immunodepletion, SDS gels, LC-MS/MS, and label-free quantitation of MS signal intensities identified 70 candidate biomarkers with differences between groups greater than 2.5-fold. (biomedsearch.com)
  • There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. (diva-portal.org)
  • A research team led by scientists at Boston University has identified several RNA-binding proteins as potential therapeutic targets and biomarkers for neurodegenerative diseases including Alzheimer's. (genomeweb.com)
  • NEW YORK (GenomeWeb) - A Roche-funded study has validated a pair of protein biomarkers as effective for evaluating the near-term risk of preeclampsia in women presenting with symptoms of the disease. (genomeweb.com)
  • Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular membrane trafficking of APP: Munc13-1, Munc18, NSF, and Eve-1. (jefferson.edu)
  • This review highlights several aspects of the regulation of mitochondrial potassium channels and uncoupling proteins in muscle mitochondria and their association with diseases. (edu.pl)
  • These transgenic lines will be analysed to understand the function and regulation of each chloroplast Clp protein for plant growth and development. (diva-portal.org)
  • Potential differential regulation among these Clp proteins was analysed at both the mRNA and protein level. (diva-portal.org)
  • Within the various lines screened, up to 90% of ClpP4 protein content was specifically repressed, which also led to the down-regulation of ClpP3 and ClpP5 protein contents. (diva-portal.org)
  • The regulation of protein function through posttranslational modification, local environment, and protein-protein interaction is critical to cellular function. (pnas.org)
  • Finally, we explored the concepts of conformational selection in proteins as a possible key component for protein-mediated transcriptional regulation. (diva-portal.org)
  • The resulting low-density, detergent-insoluble membrane fraction is enriched not only in cholesterol and glycosphingolipids but also in certain proteins, including multiple glycosylphosphatidylinositol (GPI)-anchored proteins ( Hooper and Turner, 1988 ). (biologists.org)
  • This is significant because it will provide a deep molecular understanding of a mitochondrial protein quality control pathway that protects cells against age-induced mitochondrial dysfunction and prevents the development of Parkinson's disease. (grantome.com)
  • Despite the molecular differences between these proteins both of them may regulate the generation of reactive oxygen species. (edu.pl)
  • Protein interaction networks can elucidate the molecular basis of diseases, which in turn can provide us with better methods for their prevention, diagnosis and treatment. (news-medical.net)
  • Protein ectodomain shedding functions as a molecular signaling switch that can activate or inactivate the released substrate protein and has emerged as a particularly important regulator of the function of EGFR ligands ( 1 ). (aacrjournals.org)
  • Heat shock protein 90 (Hsp90) is a molecular chaperone involved in maintaining the correct conformation and stability of its client proteins. (aacrjournals.org)
  • Molecular chaperones, such as heat shock protein 90 (Hsp90), enable the correct folding, maturation, and subcellular localization of their client proteins, particularly under the stress conditions induced by hypoxia and nutrient deprivation frequently found in cancers ( 11 ). (aacrjournals.org)
  • This reveals the active sites, giving a good indication of what the proteins do (Journal of Molecular Biology, vol 282, p 703). (newscientist.com)
  • Stewart, M. Molecular mechanism of the nuclear protein import cycle. (nature.com)
  • Understanding the structural and functional peculiarities of these proteins molecular machineries will help in formulating structure-based drug design. (diva-portal.org)
  • Adam protein ( A Disintegrin and Metalloproteinase Protein ) is a family of peptidase proteins [1] . (wikidoc.org)
  • Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins. (nih.gov)
  • Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. (nih.gov)
  • Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. (nih.gov)
  • Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins. (nih.gov)
  • Characterization of these two ADAM family members showed that they are both processed during sperm maturation and present on mature sperm. (rupress.org)
  • Collectively, these data indicate that a second ADAM family member, cyritestin, functions with fertilin β in sperm-egg plasma membrane adhesion leading to fusion. (rupress.org)
  • Three-dimensional domain architecture of the ADAM family proteinases. (nih.gov)
  • This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. (genecards.org)
  • After many years of this work, Alfandari and colleagues are now getting more into the detail of what the ADAM family of proteins can do, he notes. (umass.edu)
  • A disintegrin and metalloproteinase (ADAM) represents a protein family possessing both metalloproteinase and disintegrin domains. (jci.org)
  • A key transcription factor involved in these processes is nuclear factor-κB (NF-κB), a hetero or homodimer of the Rel family of proteins, including p65, c-Rel, RelB, p50, and p52. (frontiersin.org)
  • A. Tavitian and A. Zahraoui , Rab Proteins and Gene Family in Animals. (elsevier.com)
  • Arabidopsis thaliana contains two nuclear XRN2/3 5′-3′ exonucleases that are homologs of yeast and human Rat1/Xrn2 proteins involved in the processing and degradation of several classes of nuclear RNAs and in transcription termination of RNA polymerase II. (edu.pl)
  • L. Hicke, T. Yoshihisa, and R. Schekman , Purification of Yeast Sec23 Protein by Complementation of Mutant Cell Lysates Deficient in ER to Golgi Transport. (elsevier.com)
  • A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene. (wikipedia.org)
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • Previously, there was only a small fraction of this knowledge, mainly because researchers could measure only a few blood proteins simultaneously in a robust manner. (cam.ac.uk)
  • It also suggests that ADAM proteins in other kinds of cells may regulate similar processes. (umass.edu)
  • These data clearly show that the protein kinase C-stimulated shedding of ACE does not require the transmembrane or cytosolic regions of the protein, and that sequestration in lipid rafts does not regulate the shedding of the protein. (biologists.org)
  • Evidence against roles for phorbol binding protein Munc13-1, ADAM adap" by Annat F Ikin, Mirsada Causevic et al. (jefferson.edu)
  • Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding. (jefferson.edu)
  • There appear to be roles for certain adhesion proteins at specific stages of adhesion complex formation. (adambyron.com)
  • The Groups provided data demonstrating an essential role of FAK in cancer progression and a breadth of information on interacting partners and cellular physiology of FAK and Src, as well as on roles of these proteins in cancer metastasis (please visit the Groups' websites (see links below) for full publications lists). (ed.ac.uk)
  • In cell-based assays, ADAM9 cleaves and releases membrane proteins with known roles in prostate epithelial proliferation and transformation, FGFR2iiib and EGF, establishing potential mechanisms for its role in carcinogenesis. (aacrjournals.org)
  • For cells to coordinate complicated processes, like their migration through tissues, networks of proteins must work together. (adambyron.com)
  • Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (cancerindex.org)
  • The sperm proteins that have received the most attention recently have homology to disintegrins, which are proteins in snake venoms that can interact with integrins. (bioscience.org)
  • abstract = "Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome. (hud.ac.uk)
  • Phototransformable fluorescent proteins: which one for which application? (researcherid.com)
  • Angiotensin-converting enzyme (ACE), a type I integral membrane protein that plays a major role in vasoactive peptide metabolism, is shed from the plasma membrane by proteolytic cleavage within the juxtamembrane stalk. (biologists.org)
  • For example, in humans, the hormone insulin and the muscle cell filaments are composed of protein. (cliffsnotes.com)
  • The hair, skin, and nails of humans are composed of proteins, as are all the hundreds of thousands of enzymes in the body. (cliffsnotes.com)
  • Most of the variants are predicted to alter protein folding while several other map to functional surface regions. (hud.ac.uk)
  • In some cases, the researchers identified multiple genetic variants influencing levels of a protein. (cam.ac.uk)
  • By combining these variants into a 'score' for that protein, they were able to identify new associations between proteins and disease. (cam.ac.uk)
  • Alternative splicing results in multiple transcript variants encoding distinct proteins. (abnova.com)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • How the nitrogenous base code is translated to an amino acid sequence in a protein is the basis for protein synthesis. (cliffsnotes.com)
  • As the protein sequence and structure databases expand rapidly a better understanding of the relationships between proteins is required. (nature.com)
  • A classification is considered that extends the sequence-based superfamilies to include proteins with similar function and three-dimensional structures but no sequence similarity. (nature.com)
  • So far there are only nine protein folds known to recur in proteins having neither sequence nor functional similarity. (nature.com)
  • The functional model indicates that epitempin could mediate the interaction between proteins localized to different synaptic sides in a static way, by forming a dimer, or in a dynamic way, by binding proteins at different times. (hud.ac.uk)
  • This protein may have important functions in the extracellular matrix. (abnova.com)
  • For example, the adhesion protein focal adhesion kinase (FAK) can be found in the nucleus of normal cells when they have undergone cellular stress. (adambyron.com)
  • Endothelin-1 (ET-1) has been implicated in coronary vasospasm by enhancing coronary vasoconstriction to vasoactive eicosanoids, and a role for protein kinase C (PKC) activation has been suggested. (ahajournals.org)
  • In both cell types, GPI-ACE, but not WT-ACE, was sequestered in caveolin or flotillin-enriched lipid rafts and was released from the cell surface by treatment with phosphatidylinositol-specific phospholipase C. When cells were treated with activators of the protein kinase C signalling cascade (phorbol myristate acetate or carbachol) the shedding of GPI-ACE was stimulated to a similar extent to that of WT-ACE. (biologists.org)
  • We show that intercellular adhesion molecule-1 (ICAM-1) is differentially expressed in human TNBC tumor tissues by immunohistochemistry and in human TNBC cell lines via quantification of gene and protein expression. (pnas.org)
  • At the proteomic level, considerable efforts have been focused on both en masse quantification and identification of proteins in a given sample and characterization of protein function. (pnas.org)
  • They have also been invited to write topical reviews on trafficking of adhesion proteins and adhesion protein networks by leading international review journals including Current Opinion in Cell Biology and Annual Review of Cell and Developmental Biology. (ed.ac.uk)
  • We reported that surface CD23 expression remained constant on primed B cells exposed to a β2AR agonist, while CD23 mRNA, total CD23 protein, and soluble CD23 (sCD23) increased. (jimmunol.org)
  • Although we found that β2AR engagement was unable to affect the level of ADAM10 protein or mRNA produced compared to primed cells alone, our recent data indicated that the β2AR-induced increase in CD23 shedding may be mediated by increased localization of mature ADAM10 with CD23. (jimmunol.org)
  • It is now clear that the protein machines that control such processes in cells are extremely complex. (adambyron.com)
  • In fact, research into the complex protein machinery that controls cell adhesion is revealing much more about the biology of cells - and diseases like cancer - than we had anticipated. (adambyron.com)
  • During leaf senescence, the cells lose essential macromolecules including proteins, lipids and nucleic acids. (springer.com)
  • Among many functions, proteins can serve as enzymes and as structural materials in cells. (cliffsnotes.com)
  • In studies supported by the NIH's National Institute of Dental and Craniofacial Research, Alfandari and colleagues including co-investigator Helene Cousin and first author and postdoctoral researcher Vikram Khedgikar, are well known for tracking individual cells in frog embryos to learn how the ADAM13 protease controls proteins in the cranial neural crest to form the jaw and face. (umass.edu)
  • Studying a protein that gives structure to the nucleus of cells, Johns Hopkins researchers stumbled upon mutations associated with familial partial lipodystrophy (FPLD), a rare disease that disrupts normal patterns of fat distribution throughout the body. (news-medical.net)
  • Our findings open new paths for learning how and why fat cells are disproportionately affected by mutations in the protein lamin A, which is found in the nucleus of most cells of the body,' says Katherine Wilson, Ph.D., professor of cell biology at the Johns Hopkins University School of Medicine. (news-medical.net)
  • Circulating tumor cells and brain metastases were also significantly reduced.Furthermore, antibody treatment of established tumors profoundly decreased metastases in a resection model.As a non-essential protein under physiological conditions, ADAM8 represents a promising novel target for treatment of TNBCs, which currently lack targeted therapies and frequently progress with fatal dissemination. (nih.gov)
  • When we find the protein differences between cancer cells and normal cells, we can use this information to detect head and neck cancer. (medindia.net)
  • S.A. Adam, R. Sterne-Marr, and L. Gerace , Analysis of Nuclear Protein Import Using Digitonin-Permeabilized Cells. (elsevier.com)
  • R. Schwaninger, H. Plutner, H. Davidson, S. Pind, and W. Balch , Transport of Protein between Endoplasmic Reticulum and Golgi Compartments in Semi-intact Cells. (elsevier.com)
  • The team tested the method on proteins that the Escherichia coli genome encodes. (newscientist.com)
  • An instruction booklet guides users through the construction of three different proteins: streptococcal -protein G, ubiquitin, and ω-conotoxin MVIIA. (acs.org)
  • The increases in protein were mirrored at the mRNA level for most ClpP isomers but not for ClpC1, ClpC2 and ClpD and ClpP5, which exhibited little change in transcript levels. (diva-portal.org)
  • In conclusion, decysin and MADDAM mRNA expression were regulated in an opposite way during monocyte differentiation: MADDAM mRNA and protein was mainly detected in DC, whereas decysin mRNA expression was mainly found in MAC. (uni-regensburg.de)
  • They have now been awarded substantial funding to explore adhesion protein networks in glioblastoma, a highly aggressive type of brain cancer, and to begin to analyse neurodegeneration-associated adhesion complexes. (ed.ac.uk)
  • Confocal microscopy images show adhesion protein channel (red) or merge with F-actin (green). (nih.gov)
  • The stroma proteins and lipids of the thylakoid membrane are the major targets for degradation. (springer.com)
  • All four proteins are localized within the stroma of chloroplasts, along with the previously identified ClpD, ClpP1 and ClpP6 proteins. (diva-portal.org)
  • The ability to analyze on a genome-wide scale protein functional activity rather than changes in protein abundance or structure would provide important new insights into complex biological processes. (pnas.org)
  • A NEW technique for predicting the functions of proteins may be a godsend for scientists trying to make sense of human genome maps due to be completed early next century. (newscientist.com)
  • Therapeutic ADAM inhibitors can potentiate anti-cancer therapy [ citation needed ] . (wikidoc.org)
  • This study not only directly led to clinical trials in the UK and internationally to test FAK inhibitors in combination with immune checkpoint blockade therapeutic in multiple cancers, but also transformed the field of cell adhesion research by emphasising the importance of nuclear shuttling of adhesion proteins and by revealing potential new therapeutic opportunities in targeting nuclear functions of these proteins. (ed.ac.uk)
  • This study investigated the effects of Hsp90 inhibitors on client protein expression and key cellular functions required for tumor angiogenesis. (aacrjournals.org)
  • The results reveal that these proteins, rather than being rapidly induced stress proteins, are primarily constitutive proteins that may also be involved in plant acclimation to different physiological conditions. (diva-portal.org)
  • As a non-essential protein under physiological conditions, ADAM8 represents a promising novel target for treatment of TNBCs, which currently lack targeted therapies and frequently progress with fatal dissemination. (nih.gov)
  • I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
  • Ever try to build a protein using a classic chemistry ball-and-stick model set? (acs.org)
  • Now, thanks to a collaboration between a chemistry professor and a sculptor, anyone can build models of α-helices, β-sheets, and even whole proteins with the Tangle Proteins Building Set . (acs.org)
  • Human ADAMTSL1 full-length ORF ( AAH30262.1, 1 a.a. - 439 a.a.) recombinant protein with GST-tag at N-terminal. (abnova.com)
  • Eve-1, an ADAM adaptor protein reported to be essential for PKC-regulated shedding of pro-EGF, was found to play no obvious role in regulated shedding of sAPPalpha. (jefferson.edu)
  • Organisms are equipped with mechanisms to cope with mitochondrial dysfunction, including the PINK1-Parkin pathway that promotes lysosomal turnover of mitochondrial proteins by autophagy (mitophagy) in response to mitochondrial dysfunction. (grantome.com)
  • Determine how mitochondrial proteins are degraded by mitophagy. (grantome.com)
  • This aim will use microscopy-based techniques to identify mitochondrial proteins degraded by mitophagy and determine if mitophagy targets preexisting or newly synthesized proteins. (grantome.com)
  • In this review we will focus on cardiac and skeletal muscle energy-dissipating systems, i.e., mitochondrial potassium channels and uncoupling proteins. (edu.pl)
  • Certain mitochondrial potassium channels (such as the ATP-regulated and large conductance calcium-activated mitochondrial potassium channels) and uncoupling proteins may be regulated in a similar manner suggesting that both are part of the energy-dissipating hub in muscle mitochondria. (edu.pl)
  • Myelin sheaths are radially organized with distinct proteins in the abaxonal (e.g., oligodendrocyte myelin glycoprotein) and inner glial (e.g. (frontiersin.org)
  • Investigators reported an association between plasma insulin-like growth factor binding protein 2 (IGFBP-2) levels and structural MRI brain measures, cognitive performance, as well as incident dementia and AD-dementia. (lww.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Chromatography in conjunction with mass-spectroscopy has been successful in analyzing the content of proteins in a given sample ( 6 , 7 ). (pnas.org)