ADAM Proteins

Metalloendopeptidases

ADAM (protein)

ADAM8

ADAM15

Notch proteins

Disintegrin

Proteases in angiogenesis

Gonocyte

ADAM28

ADAM9

Adam Eyre-Walker

Sheddase

ADAM10

ADAM12

ADAM11

Green iguana

Green iguana in captivity

Ancient protein

Hib vaccine

Photoactivatable fluorescent protein

ADAMDEC1

Critical Assessment of Function Annotation

Adam Bogdanove

Mitochondrial dynamics protein MID49

Open protein structure annotation network

ADAM3

Alpha secretase

RRBP1

ADAM7

Ubiquitin-Protein Ligase E3B

ADAMTS6

Environmental vegetarianism

Coronavirus nucleocapsid protein

Genome size

Fragmentation (cell biology)

Diseases of poverty

CADASIL

Standard BioTools

Mitochondrial DNA

Congenital mirror movement disorder

Syntaxin 3

Timeline of human evolution

Biophoton

Xanthoferrin

RNA-targeting small molecule drugs

Comfort women

MECP2 duplication syndrome

CD151

WormBook

Androgen

TRADD

Activated protein C-protein C inhibitor

Coffin-Lowry syndrome

Enzyme inhibitor

Aaron Novick

Cattle feeding

Biofouling

Dihydrolipoamide dehydrogenase

Battle of Kamdesh

Alpha-Ketoisocaproic acid

Histophilus somni

Disintegrin1

• Disintegrin-like proteins are found in various species ranging from slime mold to humans. (embl.de)

Receptors2

• Cell adhesion complexes - protein complexes that form with adhesion receptors in the cell membrane and mediate interactions between neighbouring cells or with molecules in the surrounding extracellular environment - and the cytoskeleton, a structure that helps cells maintain their shape and internal organisation, have well established functions as sensors of mechanical forces and key mediators of mechanotransduction. (ed.ac.uk)
• Bioinformatics Analysis of the Genetic and Epigenetic Alterations of Bone Morphogenetic Protein Receptors in Metastatic Breast Cancer. (cdc.gov)

Inhibition1

• Carriage rates may be enhanced by the inhibition of an important barrier protein called filaggrin (FLG) and FLG loss of function genetic variation is known to decrease barrier proteins thought to inhibit the colonization of S. aureus and other pathogens," the researchers wrote. (medscape.com)

Humans5

• Hemp also holds future promise as protein for humans, says Russell, who notes that several Scottish farmers have recently replaced cattle with growing hemp instead . (newscientist.com)
• The protein appeared to have a mutation in all humans that they examined. (creation.com)
• However, chimpanzees, gorillas, orangutans and macaques all express the full-length protein, which is incorporated into Type II bundles, so the jaw muscle is comparatively larger in these animals than in humans (figure 1). (creation.com)
• However, in this case, the mRNA for the protein is transcribed and appropriately spliced, although the protein was undetectable in the humans examined. (creation.com)
• Virus expressing NSP12L323 was less sensitive to perturbations in PP2A and supports the paradigm that ongoing genotype to phenotype adaptation of SARS-CoV-2 in humans is not exclusively restricted to the spike protein. (bvsalud.org)

Recombinant5

• CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
• Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
• In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
• The recombinant C-tail proteins bind to acidic lipids via a basic charge cluster located near the C-terminus of the C-tails. (bvsalud.org)
• To explore this question further we made two recombinant viruses, firstly a control virus (WT) based on the genome sequence of the original Wuhan isolate and with the inclusion of the early D614G mutation in the Spike protein. (bvsalud.org)

Gene11

• Her lab is also tackling the problem of gene identification: devising software that can help indicate where in the mind-numbingly vast strings of DNA sequences (most of which are random filler called introns) lie the bits and pieces of actual genes that carry the blueprints for proteins. (technologyreview.com)
• Edinburgh-led study identifies a novel function for the cell adhesion protein Mena at the nuclear membrane, where it regulates actin-nuclear lamina associations, nuclear architecture, chromatin repositioning and gene expression. (ed.ac.uk)
• For quite a while, researchers have known that mechanical forces are important for regulation of multiple cellular processes, including genome organisation and gene expression in the cell nucleus, but the mechanisms involved and the links between cell adhesion complexes, cytoskeletal proteins and nuclear functions remain poorly understood. (ed.ac.uk)
• They discovered that Mena interacts with the nuclear envelope protein nesprin-2 and that it regulates the morphology of the nucleus, the organisation of chromatin and gene expression. (ed.ac.uk)
• Variants (also called mutations) in the SLC7A7 gene cause lysinuric protein intolerance. (medlineplus.gov)
• The SLC7A7 gene provides instructions for producing a protein called y+L amino acid transporter 1 (y+LAT-1), which is involved in transporting lysine, arginine, and ornithine between cells in the body. (medlineplus.gov)
• Broer S. Lysinuric protein intolerance: one gene, many problems. (medlineplus.gov)
• [ 7 , 8 ] The gene for protein C is located on the long arm of chromosome 2 and nearly 200 pathogenic mutations of this gene have been described. (medscape.com)
• A range of causative genetic alterations within the protein C promoter region and splice sites as well as in the coding sequence of the protein C gene itself have been reported. (medscape.com)
• Type II protein C deficiency is less common than type I disease and is associated with decreased functional activity and normal immunologic levels of protein C. A number of point mutations within the protein C gene giving rise to this disorder have been described. (medscape.com)
• A recent study identified a possible deactivating mutation in the gene for a human jaw muscle protein (MYH16). (creation.com)

Adhesion2

• They employed cutting-edge technologies, including quantitative proteomics, high- and super-resolution cell imaging and DNA sequencing, to show that a protein called Mena, which is usually found at sites of cell adhesion near the plasma membrane, has a role in transmitting force from the cytoskeleton into the nucleus of cells. (ed.ac.uk)
• They contain a 'RGD' sequence, identical to the recognition site of many adhesion proteins. (embl.de)

Genetic3

• Congenital protein C deficiency is one of several inherited thrombophilias, which are a heterogeneous group of genetic disorders associated with an elevated risk of venous thromboembolism. (medscape.com)
• Individuals who are homozygous or compound heterozygous for a mutation or other genetic defect affecting the protein C, typically due to the inheritance of abnormal alleles from both parents, can experience neonatal purpura fulminans, intracranial thromboembolism, and thrombosis. (medscape.com)
• Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non-hispanic white women: The breast cancer health disparities study. (cdc.gov)

Motifs1

• Ubiquitin is then transferred to ubiquitin conjugases (E2), and is finally conjugated to lysine residues within the substrate, or to the N-terminal amino group, by an ubiquitin (E3) ligase, which recognizes specific motifs in the targeted protein. (frontiersin.org)

Degradation4

• The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in eukaryotes. (frontiersin.org)
• The neuron-specific F-box protein Fbx2 ubiquitinates β-secretase thus targeting it for proteasomal degradation and reducing generation of Aβ. (frontiersin.org)
• The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system ( Schwartz and Ciechanover, 2009 ). (frontiersin.org)
• She discovered a new protein translational mechanism regulating production of a key ubiquitin ligase, involved in protein degradation. (washington.edu)

Ubiquitin1

• The ubiquitin hydrolase (Uch-L1) has been proposed to increase cellular levels of mono-ubiquitin and hence to increase rates of protein turnover by the UPS. (frontiersin.org)

Folds1

• Douglas Axe is a protein scientist who has published work on the rarity of new protein folds by doing research on beta-lactamase enzymes. (evolutionnews.org)

Extracellular2

• Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. (embl.de)
• They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain. (bvsalud.org)

Inhibitors1

• A mass spectrometry analysis was performed using serum from patients receiving checkpoint inhibitors to define baseline protein signatures associated with outcome in metastatic melanoma. (aacrjournals.org)

Transition2

• He founded the method of phi value analysis for studying protein folding transition states and methods for high resolution analysis of protein folding in the sub-millisecond time-scale. (cam.ac.uk)
• This week's Fix the Planet takes a closer look at some of the options and the potential pitfalls in the transition to alternative proteins. (newscientist.com)

Concentration1

• Type I protein C deficiency refers to a quantitative deficiency in the plasma protein C concentration. (medscape.com)

Sequence1

• Bonnie Berger is leading a group of computational biologists to develop software that uses mathematical algorithms to predict protein folding based on the sequence of amino acids. (technologyreview.com)

Inheritance1

• Heterozygous protein C deficiency is inherited in an autosomal dominant fashion, however, in families with individuals with complete deficiency, the mode of inheritance is autosomal recessive. (medscape.com)

Mutation3

• [ 13 ] The presence of a second thrombophilic mutation such as factor V Leiden has been associated with a more severe phenotype in some protein C-deficient kindreds. (medscape.com)
• Did a jaw muscle protein mutation lead to increased cranial capacity in man? (creation.com)
• This mutation resulted in a truncation of the protein that would prevent its incorporation into large bundles, resulting in a much smaller muscle. (creation.com)

Typically3

• Because the body cannot absorb these amino acids, which are found in many protein-rich foods, nausea and vomiting are typically experienced after ingesting protein. (medlineplus.gov)
• The signs and symptoms of lysinuric protein intolerance typically appear after infants are weaned and receive greater amounts of protein from solid foods. (medlineplus.gov)
• Heterozygous individuals typically demonstrate protein C antigen and activity levels that are approximately one half that of normal patient plasma. (medscape.com)

Structures3

• We have been accustomed for over 50 years of thinking of proteins as beautifully folded structures. (cam.ac.uk)
• Dr Paula Salgado and a team from Newcastle Structural Biology Lab - Dr Arnaud Basle , Dr Will Stanley, Adam Crawshaw and Chris Hoyland - organised an activity where children and adults explored the world of protein structures. (ncl.ac.uk)
• Children and adults had a chance to grow their own protein crystals, play with 3D printed protein models and "giant microbes" from which our proteins of interest come from and use the latest 3D screen technology to see "inside" our protein structures. (ncl.ac.uk)

Drugs1

• Sir Alan will use the tumour suppressor p53 as a paradigm to represent those facets of protein structure, their importance and how his group is designing new drugs to stabilise proteins. (cam.ac.uk)

Amino1

• Lysinuric protein intolerance is a disorder caused by the body's inability to digest and use certain protein building blocks (amino acids), namely lysine, arginine, and ornithine. (medlineplus.gov)

Demonstrate1

• Here, we demonstrate that the C-tail contributes to the protein expression of both K3 and K5. (bvsalud.org)

Structure4

• One of the "grand challenges" facing biologists is predicting the complex three-dimensional structure of proteins. (technologyreview.com)
• Yuzhen Ye & Adam Godzik (2003) Flexible structure alignment by chaining aligned fragment pairs allowing twists. (biojava.org)
• Sir Alan Fersht is a pioneer of protein engineering, which he developed for the analysis of the structure, activity and folding of proteins. (cam.ac.uk)
• Protein structure is not the easiest concept to grasp for most audiences, so we used a very "hands-on" approach. (ncl.ac.uk)

Make3

• to the rest of the body is necessary for the body to be able to make and use proteins. (medlineplus.gov)
• A host of alternative proteins are competing, from plant-based ones (currently mostly wheat, soy or pea-based options) and "lab-grown" meat to insects and microbes that make animal proteins. (newscientist.com)
• Scientists began to explore ways of synthesising natural protein fibres such as wool by chemically treating proteins to make them more amenable to being spun into yarns. (vam.ac.uk)

Complex1

• The functioning of NSP12 was dependent on the T-complex protein Ring Complex, a molecular chaperone. (bvsalud.org)

Contrast1

• In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere. (rndsystems.com)

Found1

• Here, we found that NSP12 formed an interactome with cellular proteins. (bvsalud.org)

Domain3

• Taxonomic distribution of proteins containing DISIN domain. (embl.de)
• The complete taxonomic breakdown of all proteins with DISIN domain is also avaliable . (embl.de)
• Click on the protein counts, or double click on taxonomic names to display all proteins containing DISIN domain in the selected taxonomic class. (embl.de)

Small1

• I had 99% protein, a rib, a fish fillet, a small piece of chicken and a little macaroni and cheese. (3fatchicks.com)

Develop1

• A food strategy commissioned by the UK government said last year that the country should develop alternative proteins. (newscientist.com)

Alternative3

• Can we afford not to seek alternative sources of protein for our food? (newscientist.com)
• Do we really need to shift to alternative proteins? (newscientist.com)
• Arguably, the biggest one is that environmental gains from alternative proteins will be at the cost of people's health, if processed alternative products add too much fat, salt and sugar. (newscientist.com)

Made3

• However, it's the only place in the world where it's been approved for sale so far, the nuggets cost about $23 for four and the bulk of them is made from plant protein. (newscientist.com)
• Scientists had been experimenting with RPFs as far back as the late 1800s when Adam Millar patented a filament made from gelatine. (vam.ac.uk)
• A variety of different protein sources were experimented with - including eggs and blood albumen, but few made it into commercial production. (vam.ac.uk)

Activity2

• But we now know that many proteins are disordered in both the test tube and the cell, and that many others unfold or misfold to lose their activity or cause toxic aggregates. (cam.ac.uk)
• The catalytic activity of aPC is greatly enhanced by the vitamin K-dependent cofactor protein S. (medscape.com)

Production1

• Human adipose tissue expresses interleukin-6, a cytokine that activates the production of C-reactive protein from the liver, potentially inducing low-grade systemic inflammation in persons with excess body fat. (who.int)

Cell1

• certain combinations of coiled proteins in virus membranes, for example, allow the virus to insinuate itself into a cell. (technologyreview.com)

Type II1

• [ 9 ] These mutations are divided into 2 types-type I and type II-on the basis of whether they cause a quantitative (type I) or functional (type II) deficiency of protein C. (medscape.com)

Mouse1

• The "self"-protein albumin in mouse airway fluid was uniquely modified by GSH-MDI at position (414)K, a preferred site of MDI reactivity on human albumin. (cdc.gov)

Important1

• The role of aPC and other anticoagulant proteins in this balance appears to be especially important in the slow-flowing venous circulation, in which procoagulant proteins and platelet phospholipids have prolonged exposure to the vessel wall. (medscape.com)

Risk1

• Protein C deficiency is a congenital or acquired condition that leads to increased risk for thrombosis. (medscape.com)

Work3

• The work, which represents a great team effort across multiple research labs, was driven by Dr Frederic Li Mow Chee and supervised by Prof Margaret Frame and Dr Adam Byron. (ed.ac.uk)
• Here, Adam shares what it's like to spend a day in his shoes - plus, his own personal playlist for those hard-at-work-in-the-kitchen hours. (toryburch.com)
• In addition to his work as a science writer, Adam writes about business and real estate for the Wall Street Journal, New York Post, and Commercial Observer . (orbooks.com)

Overview1

• Noguchi A, Takahashi T. Overview of symptoms and treatment for lysinuric protein intolerance. (medlineplus.gov)

Years1

• Adam Bonislawski is a science writer with more than 10 years of experience covering genomic and proteomic research and diagnostics development with a focus on cancer and early detection. (orbooks.com)

Human1

• If protein isolates from gorse were shown to be safe, they could be considered for human food in the future too, she says. (newscientist.com)

People2

• seen in people with lysinuric protein intolerance. (medlineplus.gov)
• It's worth saying that, in the UK at least, most people eat more protein than they need, about 50 per cent more on average than guidelines recommend . (newscientist.com)

Explain2

• This may explain, in part, why protein C deficiency appears to be associated primarily with venous thrombosis. (medscape.com)
• There are significant structural features in the viral genomic RNA that could, by themselves, explain the retention of the ORF10 nucleotide sequences without the need for a functional protein product. (bvsalud.org)

Form1

• which processes the excess nitrogen (in the form of ammonia) that is generated when protein is used by the body. (medlineplus.gov)

Activation1

• Its activation into the serine-protease-like enzyme, activated protein C (aPC), is catalyzed by thrombin when it is bound to the endothelial proteoglycan thrombomodulin. (medscape.com)