4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.Acyl Coenzyme A: S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.Acylation: The addition of an organic acid radical into a molecule.Quorum Sensing: A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.Chitosan: Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.Acyl-Butyrolactones: Cyclic esters of acylated BUTYRIC ACID containing four carbons in the ring.HomoserineChromobacterium: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria occurring in soil and water. Its organisms are generally nonpathogenic, but some species do cause infections of mammals, including humans.Lactones: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)IllinoisPsychology, Experimental: The branch of psychology which seeks to learn more about the fundamental causes of behavior by studying various psychologic phenomena in controlled experimental situations.National Socialism: The doctrines and policies of the Nazis or the National Social German Workers party, which ruled Germany under Adolf Hitler from 1933-1945. These doctrines and policies included racist nationalism, expansionism, and state control of the economy. (from Columbia Encyclopedia, 6th ed. and American Heritage College Dictionary, 3d ed.)Bland White Garland Syndrome: A congenital coronary vessel anomaly in which the left main CORONARY ARTERY originates from the PULMONARY ARTERY instead of from AORTA. The congenital heart defect typically results in coronary artery FISTULA; LEFT-SIDED HEART FAILURE and MITRAL VALVE INSUFFICIENCY during the first months of life.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Pseudomonas syringae: A species of gram-negative, fluorescent, phytopathogenic bacteria in the genus PSEUDOMONAS. It is differentiated into approximately 50 pathovars with different plant pathogenicities and host specificities.Siderophores: Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Plant Diseases: Diseases of plants.Oligopeptides: Peptides composed of between two and twelve amino acids.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Lycopersicon esculentum: A plant species of the family SOLANACEAE, native of South America, widely cultivated for their edible, fleshy, usually red fruit.Bacillus cereus: A species of rod-shaped bacteria that is a common soil saprophyte. Its spores are widespread and multiplication has been observed chiefly in foods. Contamination may lead to food poisoning.Claviceps: A genus of ascomycetous fungi, family Clavicipitaceae, order Hypocreales, parasitic on various grasses (POACEAE). The sclerotia contain several toxic alkaloids. Claviceps purpurea on rye causes ergotism.Genetic Loci: Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.MSX1 Transcription Factor: A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Wnt Proteins: Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.Spirulina: A genus of filamentous CYANOBACTERIA found in most lakes and ponds. It has been used as a nutritional supplement particularly due to its high protein content.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Pentanones: 5-carbon straight-chain or branched-chain ketones.Bence Jones Protein: An abnormal protein with unusual thermosolubility characteristics that is found in the urine of patients with MULTIPLE MYELOMA.New YorkDrugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Bryopsida: A class of plants within the Bryophyta comprising the mosses, which are found in both damp (including freshwater) and drier situations. Mosses possess erect or prostrate leafless stems, which give rise to leafless stalks bearing capsules. Spores formed in the capsules are released and grow to produce new plants. (Concise Dictionary of Biology, 1990). Many small plants bearing the name moss are in fact not mosses. The "moss" found on the north side of trees is actually a green alga (CHLOROPHYTA). Irish moss is really a red alga (RHODOPHYTA). Beard lichen (beard moss), Iceland moss, oak moss, and reindeer moss are actually LICHENS. Spanish moss is a common name for both LICHENS and an air plant (TILLANDSIA usneoides) of the pineapple family. Club moss is an evergreen herb of the family LYCOPODIACEAE.Lauraceae: A family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.Ectromelia: Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, phocomelia, and sirenomelia.Saint Vincent and the Grenadines: A self-governing state of the Windward Islands in the West Indies, comprising Saint Vincent and the northern islets of the Grenadines. Its capital is Kingstown. It is one of the original homes of the Carib Indians supposed to have been sighted by Columbus in 1498. It was in English hands from 1627 till held by the French 1779-83. Saint Vincent subsequently became a British possession and, with other nearby British territories, was administered by the Governor of the Windward Islands till 1959. It attained a measure of independence in 1969 but achieved full independence as Saint Vincent and the Grenadines in 1979. Saint Vincent was the 4th century Spanish martyr on whose feast day Columbus discovered the island. Grenadines is derived from the Spanish kingdom of Granada. (From Webster's New Geographical Dictionary, 1988, p1054 & The Europa World Year Book 1993, p2441)Nail Diseases: Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive: An autosomal recessive form of ectodermal dysplasia which is due to mutations in the gene for the EDAR RECEPTOR or EDAR-ASSOCIATED DEATH DOMAIN PROTEIN.BooksLiterature, ModernScalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).AlchemyStreptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Streptomyces griseus: An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.Streptomyces coelicolor: A soil-dwelling actinomycete with a complex lifecycle involving mycelial growth and spore formation. It is involved in the production of a number of medically important ANTIBIOTICS.Streptomyces lividans: An actinomycete used for production of commercial ANTIBIOTICS and as a host for gene cloning.Antiparasitic Agents: Drugs used to treat or prevent parasitic infections.Streptomyces antibioticus: An actinomycete from which the antibiotic OLEANDOMYCIN is obtained.
Thermoregulation of N-acyl homoserine lactone-based quorum sensing in the soft rot bacterium Pectobacterium atrosepticum. (1/173)
The psychrotolerant bacterium Pectobacterium atrosepticum produces four N-acyl homoserine lactones under a wide range of temperatures. Their thermoregulation differs from that of the exoenzyme production, described as being under quorum-sensing control. A mechanism involved in this thermoregulation consists of controlling N-acyl homoserine lactones synthase production at a transcriptional level. (+info)The plant pathogen Pantoea ananatis produces N-acylhomoserine lactone and causes center rot disease of onion by quorum sensing. (2/173)
A number of gram-negative bacteria have a quorum-sensing system and produce N-acyl-l-homoserine lactone (AHL) that they use them as a quorum-sensing signal molecule. Pantoea ananatis is reported as a common colonist of wheat heads at ripening and causes center rot of onion. In this study, we demonstrated that P. ananatis SK-1 produced two AHLs, N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxohexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). We cloned the AHL-synthase gene (eanI) and AHL-receptor gene (eanR) and revealed that the deduced amino acid sequence of EanI/EanR showed high identity to those of EsaI/EsaR from P. stewartii. EanR repressed the ean box sequence and the addition of AHLs resulted in derepression of ean box. Inactivation of the chromosomal eanI gene in SK-1 caused disruption of exopolysaccharide (EPS) biosynthesis, biofilm formation, and infection of onion leaves, which were recovered by adding exogenous 3-oxo-C6-HSL. These results demonstrated that the quorum-sensing system involved the biosynthesis of EPS, biofilm formation, and infection of onion leaves in P. ananatis SK-1. (+info)Theoretical study of molecular determinants involved in signal binding to the TraR protein of Agrobacterium tumefaciens. (3/173)
N-acylated homoserine lactone (AHL) mediated cell-cell communication in bacteria is dependent on the recognition of the cognate signal by its receptor. This interaction allows the receptor-ligand complex to act as a transcriptional activator, controlling the expression of a range of bacterial phenotypes, including virulence factor expression and biofilm formation. One approach to determine the key features of signal- binding is to model the intermolecular interactions between the receptor and ligand using computational-based modeling software (LigandFit). In this communication, we have modeled the crystal structure of the AHL receptor protein TraR and its AHL signal N-(3- oxooctanoyl)-homoserine lactone from Agrobacterium tumefaciens and compared it to the previously reported antagonist behaviour of a number of AHL analogues, in an attempt to determine structural constraints for ligand binding. We conclude that (i) a common conformation of the AHL in the hydrophobic and hydrophilic region exists for ligand-binding, (ii) a tail chain length threshold of 8 carbons is most favourable for ligand-binding affinity, (iii) the positive correlation in the docking studies could be used a virtual screening tool. (+info)Production of acyl-homoserine lactone quorum-sensing signals is widespread in gram-negative Methylobacterium. (4/173)
Members of Methylobacterium, referred as pink-pigmented facultative methylotrophic bacteria, are frequently associated with terrestrial and aquatic plants, tending to form aggregates on the phyllosphere. We report here that the production of autoinducer molecules involved in the cell-to-cell signaling process, which is known as quorum sensing, is common among Methylobacterium species. Several strains of Methylobacterium were tested for their ability to produce N-acyl-homoserine lactone (AHL) signal molecules using different indicators. Most strains of Methylobacterium tested could elicit a positive response in Agrobacterium tumefaciens harboring lacZ fused to a gene that is regulated by autoinduction. The synthesis of these compounds was cell-density dependent, and the maximal activity was reached during the late exponential to stationary phases. The bacterial extracts were separated by thin-layer chromatography and bioassayed with A. tumefaciens NT1 (traR, tra::lacZ749). They revealed the production of various patterns of the signal molecules, which are strain dependent. At least two signal molecules could be detected in most of the strains tested, and comparison of their relative mobilities suggested that they are homologs of N-octanoyl-DL-homoserine lactone (C8-HSL) and N-decanoyl-DL-homoserine lactone (C10-HSL). (+info)The acyl-homoserine lactone-type quorum-sensing system modulates cell motility and virulence of Erwinia chrysanthemi pv. zeae. (5/173)
Erwinia chrysanthemi pv. zeae is one of the Erwinia chrysanthemi pathovars that infects on both dicotyledons and monocotyledons. However, little is known about the molecular basis and regulatory mechanisms of its virulence. By using a transposon mutagenesis approach, we cloned the genes coding for an E. chrysanthemi pv. zeae synthase of acyl-homoserine lactone (AHL) quorum-sensing signals (expI(Ecz)) and a cognate response regulator (expR(Ecz)). Chromatography analysis showed that expI(Ecz) encoded production of the AHL signal N-(3-oxo-hexanoyl)-homoserine lactone (OHHL). Null mutation of expI(Ecz) in the E. chrysanthemi pv. zeae strain EC1 abolished AHL production, increased bacterial swimming and swarming motility, disabled formation of multicell aggregates, and attenuated virulence of the pathogen on potato tubers. The mutation also marginally reduced the inhibitory activity of E. chrysanthemi pv. zeae on rice seed germination. The mutant phenotypes were rescued by either exogenous addition of AHL signal or in trans expression of expI(Ecz). These data demonstrate that the AHL-type QS signal plays an essential role in modulation of E. chrysanthemi pv. zeae cell motility and the ability to form multicell aggregates and is involved in regulation of bacterial virulence. (+info)Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa. (6/173)
(+info)Inter-kingdom signalling: communication between bacteria and their hosts. (7/173)
(+info)Characteristics of the LrhA subfamily of transcriptional regulators from Sinorhizobium meliloti. (8/173)
In our previous work, we identified 94 putative genes encoding LysR-type transcriptional regulators from Sinorhizobium meliloti. All of these putative lysR genes were mutagenized using plasmid insertions to determine their phenotypes. Six LysR-type regulators, encoded by mutants SMa1979, SMb20715, SMc00820, SMc04163, SMc03975, and SMc04315, showed similar amino acid sequences (30%) and shared the conserved DNA-binding domain with LrhA, HexA, or DgdR. Phenotype analysis of these gene mutants indicated that the regulators control the swimming behaviors of the bacteria, production of quorum-sensing signals, and secretion of extracellular proteins. These characteristics are very similar to those of LrhA, HexA, and DgdR. Thus, we refer to this group as the LrhA subfamily. Sequence analysis showed that a great number of homologous genes of the LrhA subfamily were distributed in the alpha, beta, and gamma subdivisions of proteobacteria, and a few in actinobacteria. These findings could provide new clues to the roles of the LysR gene family. (+info)3P The reaction product of ethylene oxide with acyl chlorides in the presence of sodium iodide is a complex iodoethyl ester: ( ... reactions of ethylene oxide with compounds containing active methylene group leads to the formation of butyrolactones: Ethylene ...
Acyl-Butyrolactones / metabolism *. Actions. * Search in PubMed * Search in MeSH * Add to Search ... Assessment of the Quorum Sensing Inhibition Activity of a Non-Toxic Chitosan in an N-Acyl Homoserine Lactone (AHL)-Based ... Assessment of the Quorum Sensing Inhibition Activity of a Non-Toxic Chitosan in an N-Acyl Homoserine Lactone (AHL)-Based ... Beneficial Effects of Bacteria-Plant Communication Based on Quorum Sensing Molecules of the N-acyl Homoserine Lactone Group A ...
Acyl-Butyrolactones/chemistry*/classification/isolation & purification*. *Bacterial Physiological Phenomena*. *Gram-Negative ... Extraction, purification and identification of bacterial signal molecules based on N-acyl homoserine lactones. ... Extraction, purification and identification of bacterial signal molecules based on N-acyl homoserine lactones. ...
γ-Butyrolactones (GBLs). Streptomyces spp.. AfsA-type GBL synthase. Acyl-ACP, glycerol. ArpA-type repressor, GBL-binding ... Acyl homoserine lactones (AHLs). Proteobacteria LuxI-type enzymes. SAM, acyl-ACP. LuxR-type proteins. Diverse processes. 21 ... SAM, acyl-ACP, acyl-CoA. Two-component kinase. Linear oligopeptides. Gram-positive organisms. Genetically encoded (e.g., B. ... acyl-CoA?. RpfC, RpfH. Virulence and pigmentation. 100 4-Hydroxy-2-alkyl quinolines (PQS, HAQs). Pseudomonads. pqsABCDE, pqsH ...
... gamma-butyrolactones and alpha-(N-alkyl-sulfonamide)-gamma-butyrolactones. Bioorg Med Chem Lett 21:6876-6879. doi:10.1016/j. ... Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus. J Bacteriol 182:6921-6926. doi:10.1128/JB ... Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infect Immun 74:1673-1682. doi: ... Multiple N-acyl-l-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri. J ...
Zhao, S., Wang, J., Du, X., Wang, J., Cao, R., Yin, Y., Zhang, X., Yuan, Z., Xing, Y., Pui, D. Y. H. & Li, C., May 29 2018, In : ACS Applied Energy Materials. 1, 5, p. 2326-2332 7 p.. Research output: Contribution to journal › Article ...
... some gram-positive bacteria produce γ-butyrolactones as quorum-sensing signals, which are structurally quite similar to AHLs ( ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ...
Acyl-Butyrolactones Genes The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST). Overbeek, ...
Thermolysis of selenocarbonate 224 in benzene at 80 8C generated the corresponding acyl radical, which underwent cyclization to ... butyrolactones Chemie The amount of research activity concerning a-methylene-g-butyrolactones and a-alkylidene-g-butyrolactones ... Traditional approaches to a-methylene-g-butyrolactones and a-alkylidene-g-butyrolactones are then reviewed together with novel ... Other a-Alkylidene-g-butyrolactones A large number of non-terpenoid, naturally occurring aalkylidene-g-butyrolactones are also ...
Acyl-Butyrolactones/metabolism. *Acyl-Butyrolactones/pharmacology. *Bacterial Adhesion/drug effects. *Candida albicans/drug ... These changes can include alterations in the levels of N-acyl homoserine lactones (HSLs), which are secreted signal molecules. ...
Fingerprint Dive into the research topics where Kazuhiro Toyoda is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Solo-Gabriele, H. M., Harwood, V. J., Kay, D., Fujioka, R. S., Sadowsky, M. J., Whitman, R. L., Wither, A., Caniça, M., Carvalho da Fonseca, R., Duarte, A., Edge, T. A., Gargaté, M. J., Gunde-Cimerman, N., Hagen, F., McLellan, S. L., Nogueira da Silva, A., Novak Babič, M., Prada, S., Rodrigues, R., Romão, D. & 9 others, Sabino, R., Samson, R. A., Segal, E., Staley, C., Taylor, H. D., Veríssimo, C., Viegas, C., Barroso, H. & Brandão, J. C., Jan 1 2016, In : Journal of the Marine Biological Association of the United Kingdom. 96, 1, p. 101-120 20 p.. Research output: Contribution to journal › Article ...
Wang, H., Tzeng, Y. K., Ji, Y., Li, Y., Li, J., Zheng, X., Yang, A., Liu, Y., Gong, Y., Cai, L., Li, Y., Zhang, X., Chen, W., Liu, B., Lu, H., Melosh, N. A., Shen, Z. X., Chan, K., Tan, T., Chu, S. & 1 others, Cui, Y., Feb 1 2020, In : Nature Nanotechnology. 15, 2, p. 131-137 7 p.. Research output: Contribution to journal › Article ...
Acyl homoserine lactone production of brewery process surface bacteria. Priha, O., Juvonen, R., Tapani, K. & Storgårds, E., ...
The acyl-homoserine lactone synthase YenI from Yersinia enterocolitica modulates virulence gene expression in enterohemorrhagic ...
Kao, Y. C., Rogers, M. W., Bunnell, D. B., Cowx, I. G., Qian, S. S., Anneville, O., Beard, T. D., Brinker, A., Britton, J. R., Chura-Cruz, R., Gownaris, N. J., Jackson, J. R., Kangur, K., Kolding, J., Lukin, A. A., Lynch, A. J., Mercado-Silva, N., Moncayo-Estrada, R., Njaya, F. J., Ostrovsky, I. & 11 others, Rudstam, L. G., Sandström, A. L. E., Sato, Y., Siguayro-Mamani, H., Thorpe, A., van Zwieten, P. A. M., Volta, P., Wang, Y., Weiperth, A., Weyl, O. L. F. & Young, J. D., 1 Dec 2020, In : Nature Communications.. Research output: Contribution to journal › Article ...
Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl ... Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl ... Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl ... Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl ...
Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ...
Collins, F. L., Schepper, J. D., Rios-Arce, N. D., Steury, M. D., Kang, H. J., Mallin, H., Schoenherr, D., Camfield, G., Chishti, S., McCabe, L. R. & Parameswaran, N., 2017, Understanding the Gut-Bone Signaling Axis: Mechanisms and Therapeutic Implications. McCabe, L. R. & Parameswaran, N. (eds.). Cham: Springer , p. 59-94 36 p. (Advances in Experimental Medicine and Biology; vol. 1033).. Research output: Chapter in Book/Report/Conference proceeding › Chapter ...
Unusual comQXPA-like loci.(A) Non-canonical unusual com system is present in B. cereus VD102, B. cereus BAG4X12 1, B. cereus MSX A1 and L. fusiformis ZC1. Note
Acyl-Butyrolactones [1]. Aerobiosis [1]. AHL [1]. Alphaproteobacteria [2]. Amino Acid Sequence [2]. ...
Acyl-Butyrolactones Medicine & Life Sciences * Enterohemorrhagic Escherichia coli Medicine & Life Sciences * Yersinia ... Nguyen, Y. N., Sheng, H., Dakarapu, R., Falck, J. R., Hovde, C. J., & Sperandio, V. (2013). The acyl-homoserine lactone ... Nguyen, YN, Sheng, H, Dakarapu, R, Falck, JR, Hovde, CJ & Sperandio, V 2013, The acyl-homoserine lactone synthase YenI from ... title = "The acyl-homoserine lactone synthase YenI from Yersinia enterocolitica modulates virulence gene expression in ...
The hydrophobic side chain of the butyrolactones, known generically also as butaneolides, is in the same locus as the N-acyl ... In the case of mycosubtilin, the first five domains of the MycA subunit are dedicated to construction of the C16-β-NH2-acyl ... The N-acylhomoserine lactones of Erwinia, Pseudomonas, and many other bacteria and the γ-butyrolactones of streptomycetes, ... in which all 10 of the ketone groups are thought to persist without reductive modification in the acyl chain. The first cyclase ...
Acyl-Butyrolactones. *Dehydroascorbic Acid. *Macrolides. *Picrotoxin. *Polyketides. *Propiolactone. *Spironolactone. * ...
Acyl-Butyrolactones: 14. *mycolactone A: 13. *phospholine: 13. *ebelactone B: 12. *ginkgolide A: 12 ...
Acyl-Butyrolactones, chemistry, metabolism, Bacterial Proteins, genetics, Biofilms, Gene Expression Regulation, Bacterial, ...
- Extraction, purification and identification of bacterial signal molecules based on N-acyl homoserine lactones. (nih.gov)
- N∼C indicates either linear or cyclized peptides, AHLs are acylated homoserine lactones, GBLs are γ-butyrolactones, AI-2 is the furanosyl borate diester, and cis -DA is cis -11-methyl-2-dodecenoic acid. (asm.org)
- The second reporter strain (AI1-QQ.1) contained the Vibrio fischeri luxI promoter fused to the ccdB gene to detect interference with acyl-homoserine lactones. (asm.org)
- N -Acyl-homoserine lactones (AHLs), also known as autoinducers, are widely conserved signal molecules that are present in the quorum-sensing systems of many gram-negative bacteria. (asm.org)
- These changes can include alterations in the levels of N-acyl homoserine lactones (HSLs), which are secreted signal molecules. (nih.gov)
- Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl homoserine lactones (AHLs), which are quorum-sensing molecules, and consequently had reduced virulence on host tobacco plants. (elsevier.com)
- We previously demonstrated that EHEC senses acyl-homoserine lactones (AHLs) produced by the microbiota in the rumen to activate the gad acid resistance genes necessary for survival through the acidic stomachs in cattle and to repress the locus of enterocyte effacement (LEE) genes important for colonization of the RAJ, but unnecessary in the rumen. (elsevier.com)
- A range of gram-negative bacterial species use N -acyl homoserine lactone (AHL) molecules as quorum-sensing signals to regulate different biological functions, including production of virulence factors. (asm.org)
- they have the same homoserine lactone moiety but differ in the length and structure of the acyl side chain. (asm.org)
- Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas aeruginosa. (elsevier.com)
- LuxN, a nine-transmembrane domain protein from Vibrio harveyi, is the founding example of membrane-bound receptors for acyl-homoserine lactone (AHL) autoinducers. (princeton.edu)
- in addition to reports describing the isolation of a-methylene- and a-alkylidene-g-butyrolactones, there have been numerous publications covering their biosynthesis, biological properties, and medical applications. (docme.ru)
- 21. Knochel P.*, Yeh M.C.P., Berk S.C., Talbert J., "Synthesis and Reactivity Toward Acyl chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI" J. Org. (uni-muenchen.de)
- Int. Ed. 2009, 48, 9426 - 9451 Angewandte a-Methylene-g-butyrolactones Chemie The amount of research activity concerning a-methylene-g-butyrolactones and a-alkylidene-g-butyrolactones has increased dramatically in recent years. (docme.ru)
- However, we will first provide a condensed overview of newly isolated a-methylene- and a-alkylidene-g-butyrolactones, their biological activity, and their biosynthesis. (docme.ru)
- Acyl-HSLs are synthesized by the LuxI family of synthases, and the signal response is mediated by members of the LuxR family of transcriptional regulators. (elsevier.com)
- We also show that a strain incapable of acyl-HSL production is capable of growth on the same assortment of carbon and nitrogen sources as the wild type. (elsevier.com)