4-Butyrolactone
Acyl Coenzyme A
Thermoregulation of N-acyl homoserine lactone-based quorum sensing in the soft rot bacterium Pectobacterium atrosepticum. (1/173)
The psychrotolerant bacterium Pectobacterium atrosepticum produces four N-acyl homoserine lactones under a wide range of temperatures. Their thermoregulation differs from that of the exoenzyme production, described as being under quorum-sensing control. A mechanism involved in this thermoregulation consists of controlling N-acyl homoserine lactones synthase production at a transcriptional level. (+info)The plant pathogen Pantoea ananatis produces N-acylhomoserine lactone and causes center rot disease of onion by quorum sensing. (2/173)
A number of gram-negative bacteria have a quorum-sensing system and produce N-acyl-l-homoserine lactone (AHL) that they use them as a quorum-sensing signal molecule. Pantoea ananatis is reported as a common colonist of wheat heads at ripening and causes center rot of onion. In this study, we demonstrated that P. ananatis SK-1 produced two AHLs, N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxohexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). We cloned the AHL-synthase gene (eanI) and AHL-receptor gene (eanR) and revealed that the deduced amino acid sequence of EanI/EanR showed high identity to those of EsaI/EsaR from P. stewartii. EanR repressed the ean box sequence and the addition of AHLs resulted in derepression of ean box. Inactivation of the chromosomal eanI gene in SK-1 caused disruption of exopolysaccharide (EPS) biosynthesis, biofilm formation, and infection of onion leaves, which were recovered by adding exogenous 3-oxo-C6-HSL. These results demonstrated that the quorum-sensing system involved the biosynthesis of EPS, biofilm formation, and infection of onion leaves in P. ananatis SK-1. (+info)Theoretical study of molecular determinants involved in signal binding to the TraR protein of Agrobacterium tumefaciens. (3/173)
N-acylated homoserine lactone (AHL) mediated cell-cell communication in bacteria is dependent on the recognition of the cognate signal by its receptor. This interaction allows the receptor-ligand complex to act as a transcriptional activator, controlling the expression of a range of bacterial phenotypes, including virulence factor expression and biofilm formation. One approach to determine the key features of signal- binding is to model the intermolecular interactions between the receptor and ligand using computational-based modeling software (LigandFit). In this communication, we have modeled the crystal structure of the AHL receptor protein TraR and its AHL signal N-(3- oxooctanoyl)-homoserine lactone from Agrobacterium tumefaciens and compared it to the previously reported antagonist behaviour of a number of AHL analogues, in an attempt to determine structural constraints for ligand binding. We conclude that (i) a common conformation of the AHL in the hydrophobic and hydrophilic region exists for ligand-binding, (ii) a tail chain length threshold of 8 carbons is most favourable for ligand-binding affinity, (iii) the positive correlation in the docking studies could be used a virtual screening tool. (+info)Production of acyl-homoserine lactone quorum-sensing signals is widespread in gram-negative Methylobacterium. (4/173)
Members of Methylobacterium, referred as pink-pigmented facultative methylotrophic bacteria, are frequently associated with terrestrial and aquatic plants, tending to form aggregates on the phyllosphere. We report here that the production of autoinducer molecules involved in the cell-to-cell signaling process, which is known as quorum sensing, is common among Methylobacterium species. Several strains of Methylobacterium were tested for their ability to produce N-acyl-homoserine lactone (AHL) signal molecules using different indicators. Most strains of Methylobacterium tested could elicit a positive response in Agrobacterium tumefaciens harboring lacZ fused to a gene that is regulated by autoinduction. The synthesis of these compounds was cell-density dependent, and the maximal activity was reached during the late exponential to stationary phases. The bacterial extracts were separated by thin-layer chromatography and bioassayed with A. tumefaciens NT1 (traR, tra::lacZ749). They revealed the production of various patterns of the signal molecules, which are strain dependent. At least two signal molecules could be detected in most of the strains tested, and comparison of their relative mobilities suggested that they are homologs of N-octanoyl-DL-homoserine lactone (C8-HSL) and N-decanoyl-DL-homoserine lactone (C10-HSL). (+info)The acyl-homoserine lactone-type quorum-sensing system modulates cell motility and virulence of Erwinia chrysanthemi pv. zeae. (5/173)
Erwinia chrysanthemi pv. zeae is one of the Erwinia chrysanthemi pathovars that infects on both dicotyledons and monocotyledons. However, little is known about the molecular basis and regulatory mechanisms of its virulence. By using a transposon mutagenesis approach, we cloned the genes coding for an E. chrysanthemi pv. zeae synthase of acyl-homoserine lactone (AHL) quorum-sensing signals (expI(Ecz)) and a cognate response regulator (expR(Ecz)). Chromatography analysis showed that expI(Ecz) encoded production of the AHL signal N-(3-oxo-hexanoyl)-homoserine lactone (OHHL). Null mutation of expI(Ecz) in the E. chrysanthemi pv. zeae strain EC1 abolished AHL production, increased bacterial swimming and swarming motility, disabled formation of multicell aggregates, and attenuated virulence of the pathogen on potato tubers. The mutation also marginally reduced the inhibitory activity of E. chrysanthemi pv. zeae on rice seed germination. The mutant phenotypes were rescued by either exogenous addition of AHL signal or in trans expression of expI(Ecz). These data demonstrate that the AHL-type QS signal plays an essential role in modulation of E. chrysanthemi pv. zeae cell motility and the ability to form multicell aggregates and is involved in regulation of bacterial virulence. (+info)Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa. (6/173)
(+info)Inter-kingdom signalling: communication between bacteria and their hosts. (7/173)
(+info)Characteristics of the LrhA subfamily of transcriptional regulators from Sinorhizobium meliloti. (8/173)
In our previous work, we identified 94 putative genes encoding LysR-type transcriptional regulators from Sinorhizobium meliloti. All of these putative lysR genes were mutagenized using plasmid insertions to determine their phenotypes. Six LysR-type regulators, encoded by mutants SMa1979, SMb20715, SMc00820, SMc04163, SMc03975, and SMc04315, showed similar amino acid sequences (30%) and shared the conserved DNA-binding domain with LrhA, HexA, or DgdR. Phenotype analysis of these gene mutants indicated that the regulators control the swimming behaviors of the bacteria, production of quorum-sensing signals, and secretion of extracellular proteins. These characteristics are very similar to those of LrhA, HexA, and DgdR. Thus, we refer to this group as the LrhA subfamily. Sequence analysis showed that a great number of homologous genes of the LrhA subfamily were distributed in the alpha, beta, and gamma subdivisions of proteobacteria, and a few in actinobacteria. These findings could provide new clues to the roles of the LysR gene family. (+info)
PLOS Pathogens: The Pseudomonas aeruginosa N-Acylhomoserine Lactone Quorum Sensing Molecules Target IQGAP1 and Modulate...
IJPBS Article- EVALUATION OF THE POTENTIAL OF FIVE MEDICINAL PLANTS TO INHIBIT ACYL HOMOSERINE LACTONE BASED QUORUM
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Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing. - PubMed - NCBI
acyl-homoserine lactone | mBio
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Thiourea-catalyzed aminolysis of N-acyl homoserine lactones
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The bacterial enigma: cracking the code of cell-cell communication
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Chemosensors | Free Full-Text | Selectivity and Efficiency of Conductive Molecularly Imprinted Polymer (c-MIP) Based on 5...
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BpiB05, a novel metagenome-derived hydrolase acting on N-acylhomoserine lactones. : CRC 1182
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N-acyl-L-homoserine lactones are inter-kingdom signalling molecules controlling quorum sensing in the Gram-negative bacteria...
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Ethylene oxide
3P The reaction product of ethylene oxide with acyl chlorides in the presence of sodium iodide is a complex iodoethyl ester: ( ... reactions of ethylene oxide with compounds containing active methylene group leads to the formation of butyrolactones: Ethylene ...
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Ravinder S. Reddy And K. Saravanan and Pradeep Kumar*, An efficient approach to ?-alkylidene ?-butyrolactones : Application to ... Pradeep Kumar and A.K. Mukerjee, Acylation of primary amines by O-acyl oximes, Synthesis., 1979, 726 (1979). ... butyrolactones. Its relevance to photo- stability of Fredericamycin A, J.Chem.Soc.Chem. Commun., 1993, 870 (1993). ...
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Acyl-Butyrolactones Medicine & Life Sciences 89% * Cattle Medicine & Life Sciences 70% * Rumen Medicine & Life Sciences 43% ... EHEC harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria. Here,we show that SdiA ... EHEC harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria. Here,we show that SdiA ... EHEC harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria. Here,we show that SdiA ...
gbl for sale - An Overview
The discrepancies in chemical framework Among the many γ-butyrolactones are classified as the size and branching from the acyl ...
Human Metabolome Database: Showing metabocard for N-Dodecanoyl-DL-homoserine lactone (HMDB0341351)
Acyl homoserine lactones *N-acyl amines *Gamma butyrolactones *Oxolanes *Secondary carboxylic acid amides ... Belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. N-acyl-alpha amino acids and ... belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. N-acyl-alpha amino acids and ... derivatives are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal ...
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C. B. Rao, N. Zhang, J. Hu, Y. Wang, Y. Liang, R. Zhang,* J.Yuan, D.Dong,* Tf2O-Mediated Cyclization of α-Acyl-β-(2- ... A Novel Entry to γ-Butyrolactones, Synthesis 2012, 1679-1685. ... Diones from α-Acyl-α-Carbamoyl Ketene-S,S-Acetals, Synthesis ... J. Yang, D. Xiang, R. Zhang, N. Zhang,* Y. Liang, X. Xin, D. Dong,* POCl3-Mediated Reaction of 1-Acyl-1-Carbamoyl Oximes: A New ... M. Yu, Q. Zhang, G. Li, J. Yuan, N. Zhang,* R. Zhang, Y. Liang, D. Dong,* Copper-Nitrene Triggered Annulation of α-Acyl ...
MeSH Browser
Acyl-Butyrolactones [D02.540.232] * Dehydroascorbic Acid [D02.540.260] * Eplerenone [D02.540.383] * Macrolides [D02.540.505] ...
Cameron Ray Smith, M.D.,Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Acyl-Butyrolactones. *Adult. *Aerosols. *Analgesics. *Anesthesia, Spinal. *Anesthetics, Local. *Animals. *Anthrax. *Antibodies ...
Daisuke Kiga - 研究成果
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Beal, J., Telmer, C. A., Vignoni, A., Boada, Y., Baldwin, G. S., Hallett, L., Lee, T., Selvarajah, V., Billerbeck, S., Brown, B., Cai, G. N., Cai, L., Eisenstein, E., Kiga, D., Ross, D., Alperovich, N., Sprent, N., Thompson, J., Young, E. M., Endy, D., & 1 othersHaddock-Angelli, T., 2022, In: Synthetic Biology. 7, 1, ysac010.. 研究成果: Article › 査読 ...
Bièrra - Wikipèdia
La bièrra sembla èsser apareguda ambé lei culturas de cerealas en Mesopotamia Anciana. Pasmens, en causa de la manca de donadas, la data precisa es desconeguda. D'un biais generau, es situada vèrs 6 000 avC car lei tecnologias dau periòde (mestritge de la produccion d'òrdi e de blat[1], terralhas capablas de protegir una bevenda alcoolizada...) permetián alora son existéncia[2]. La premiera traça clarament atestada data dau milleni IV avC e foguèt descubèrta en Sumèr. Dicha « sikaru », fasiá partida dau manjar de la vida vidante e sa fabricacion èra protegida per la divessa Ninkasi[3]. Èra producha a partir de fogassas d'òrdi ò d'espèuta trempadas dins l'aiga per entraïnar la fermentacion. D'autreis ingredients i èran de còps aponduts (mèu, espècias...) per ne melhorar lo gost. A partir de Mesopotamia, la bièrra se difusèt vèrs lei regions vesinas[4]. Pasmens, es tanben possible que dins certaneis endrechs, de descubèrtas independentas aguèron luòc. Que mecanisme ...
Bel-Air - Simple English Wikipedia, the free encyclopedia
Bel Air (or Bel-Air) is a neighborhood in the Los Angeles Westside, in the foothills of the Santa Monica Mountains. It was founded in 1923. It is a lightly populated residential district. The people are older, well-educated, and have high incomes. ...
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Schooda - Boarische Wikipedia
Schooda (dt.: Schotter, engl.: crushed stone (kinstle), gravel (natiale)) san kloane Breckal bzw. Keandln vo Stoana und Fejsn, wo natiale oda kinstle entstondn san und gressa wia 2 mm san. Wonns kloana san, is's a Sond. A Schooda wo natiale entstondn is, nennd ma aa Kisl. A Schooda wo kinstle brocha is, nennd ma Splitt. ...
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Gallout a reer implijout an testennoù zo dindan an Aotre-Implijout Creative Commons Dereiñ/Kenrannañ diouzh an hevelep divizoù; divizoù ouzhpenn a c'hall bezañ ivez. Gwelet an Doareoù Implijout evit gouzout hiroc'h ...
Tofauti kati ya marekesbisho "Mkoa wa Alicante", kamusi elezo huru
picha_ya_satelite = Localización de la provincia de Alicante. ...
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Ta Lanreunan (Frangish: Laurenan, Galloish: Laor'nan) ny chommyoon 'sy département Frangagh Aodoù-an-Arvor 'sy Vritaan ayns sheear hwoaie ny Frank. Ta'n ennym Frangish Laurenanais currit er cummaltee yn valley. ...
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Maldiv, an form long Répiblik dé Maldiv (an dhivehi : ދިވެހިރާއްޖޭގެ ޖުމްހޫރިއްޔާ, Dhivehi Raa'jeyge Jumhooriyya), sa roun péyi di Lazi di Sid konstitchwé di 1 199 zil, don 202 ki gen moun ki ka rété, sitchwé o sid-wès di sou-kontinan endyen. ...
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Si Papa Leó III(750 - 12 Hunyo 816) ang Papa ng Simbahang Katoliko Romano mula 795 CE hanggang sa kanyang kamatayan noong 816 CE. Siya ay iningatan ni Charlemagne mula sa kanyang mga kaaway sa Roma. Kanyang kalaunang pinakalakas ang posisyon ni Charlemagne sa pamamagitan ng pagkorona rito bilang Banal na Emperador Romano. ...
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Sergio Osmeña
Hi Osmeña usa nga abogado ngan editor hin periodiko ugsa hiya mahibulig ha lokal nga mga politika. Nagtikáng hiya komo konsehal. Han 1904, an Amerikano nga kolonyal nga administrasyon naghimo ha iya nga gobernador han Sugbo o Cebu. Kaatapos hin duha ka tuig, na-elihir hiya nga gobernador han Sugbo. Samtang gobernador hiya, nagdalagan hiya dida han pinili-ay para han syahan nga Kapulongan Pilipinhon o Philippine Assembly han 1907 ngan napili hiya nga Speaker hadton nga kapulongan. Hi Osmeña 29 pa la an edad han kahimo niya nga gihataasi in ranggo nga opisyal Pilipino hadto nga panahon. Hiya ngan in usa liwat nga politiko, nga hi Manuel L. Quezon han Tayabas, nagtukod han Partido Nacionalista komo baton han Partido Federalista han mga politiko-ha-Manila. An duha nagkaada hin pagkaribal para hin kadominante ha politika tikang hini nga panahon. ...
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Senado ti Filipinas, ti nawaya nga ensiklopedia
Ti Senado ti Filipinas ket ti akin-ngato a benneg ti bikameral a lehislatura ti Filipinas (Kongreso ti Filipinas). Buklen ti 24 a senador ti Senado, a mabutosan iti maysa a nailian nga eleksion. Saan nga ibagian ti maysa a senador ti maysa a partikular a geograpikal a distrito. Agpaay dagiti senador iti 6 a tawen a termino. Kaguadua (12) dagiti senador ti mabutosan iti kada tallo a tawen. ...
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Daisuke Kiga - 研究成果 - 早稲田大学
Beal, J., Telmer, C. A., Vignoni, A., Boada, Y., Baldwin, G. S., Hallett, L., Lee, T., Selvarajah, V., Billerbeck, S., Brown, B., Cai, G. N., Cai, L., Eisenstein, E., Kiga, D., Ross, D., Alperovich, N., Sprent, N., Thompson, J., Young, E. M., Endy, D., & 1 othersHaddock-Angelli, T., 2022, In: Synthetic Biology. 7, 1, ysac010.. 研究成果: Article › 査読 ...
Chemical sensing in mammalian host-bacterial commensal associations<...
Acyl-Butyrolactones Medicine & Life Sciences 89% * Cattle Medicine & Life Sciences 70% * Rumen Medicine & Life Sciences 43% ... EHEC harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria. Here,we show that SdiA ... EHEC harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria. Here,we show that SdiA ... EHEC harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria. Here,we show that SdiA ...
Cameron Ray Smith, M.D.,Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Asymmetric Homoenolate Additions to Acyl Phosphonates through Rational Design of a Tailored N-Heterocyclic Carbene Catalyst | P...
Rational Design of a Tailored N-Heterocyclic Carbene CatalystA highly selective NHC-catalyzed synthesis of γ-butyrolactones ... Asymmetric Homoenolate Additions to Acyl Phosphonates through Rational Design of a Tailored N-Heterocyclic Carbene Catalyst. ... A highly selective NHC-catalyzed synthesis of γ-butyrolactones from the fusion of enals and α-ketophosphonates has been ... Home » Asymmetric Homoenolate Additions to Acyl Phosphonates through Rational Design of a Tailored N-Heterocyclic Carbene ...
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Human Metabolome Database: Showing metabocard for N-Dodecanoyl-DL-homoserine lactone (HMDB0341351)
Acyl homoserine lactones *N-acyl amines *Gamma butyrolactones *Oxolanes *Secondary carboxylic acid amides ... Belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. N-acyl-alpha amino acids and ... belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. N-acyl-alpha amino acids and ... derivatives are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal ...
Ethylene oxide - Wikipedia
CSIR-National Chemical Laboratory Faculty
Ravinder S. Reddy And K. Saravanan and Pradeep Kumar*, An efficient approach to ?-alkylidene ?-butyrolactones : Application to ... Pradeep Kumar and A.K. Mukerjee, Acylation of primary amines by O-acyl oximes, Synthesis., 1979, 726 (1979). ... butyrolactones. Its relevance to photo- stability of Fredericamycin A, J.Chem.Soc.Chem. Commun., 1993, 870 (1993). ...
已发表文章 - 董德文课题组
C. B. Rao, N. Zhang, J. Hu, Y. Wang, Y. Liang, R. Zhang,* J.Yuan, D.Dong,* Tf2O-Mediated Cyclization of α-Acyl-β-(2- ... A Novel Entry to γ-Butyrolactones, Synthesis 2012, 1679-1685. ... Diones from α-Acyl-α-Carbamoyl Ketene-S,S-Acetals, Synthesis ... J. Yang, D. Xiang, R. Zhang, N. Zhang,* Y. Liang, X. Xin, D. Dong,* POCl3-Mediated Reaction of 1-Acyl-1-Carbamoyl Oximes: A New ... M. Yu, Q. Zhang, G. Li, J. Yuan, N. Zhang,* R. Zhang, Y. Liang, D. Dong,* Copper-Nitrene Triggered Annulation of α-Acyl ...
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Benzoins via an acyl anion equivalent. Novel one-pot preparation of benzo[b]furans via benzoins using hydriodic acid ... Substituted .gamma.-butyrolactones. Part 32. Ring construction using 3-(arylmethylene)-2,4(3H,5H)-furandione: synthesis of ... I. Preparation of α-Substituted γ-Butyrolactones by Condensation of γ-Butyrolactone with Aldehydes. Hydrogenation of the ...
Ionic Liquids for the Synthesis of Five-Membered N,N-, N,N,N- and N,N,N,NHeterocycles
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Lactones2
- Salmonella is an important foodborne pathogen, and it is unable to produce the quorum sensing signaling molecules called acyl-homoserine lactones (AHLs). (nih.gov)
- A treatment of normal and cancer cells with C12 or other N-acyl homoserine lactones (AHLs) results in rapid translocation of MVP into lipid raft (LR) membrane fractions. (bgu.ac.il)
HOMOSERINE1
- The organism has two acyl-homoserine lactone (HSL)-mediated QS systems, LasR/LasI and RhlR/RhlI. (elsevier.com)