Bacillus cereus: A species of rod-shaped bacteria that is a common soil saprophyte. Its spores are widespread and multiplication has been observed chiefly in foods. Contamination may lead to food poisoning.Claviceps: A genus of ascomycetous fungi, family Clavicipitaceae, order Hypocreales, parasitic on various grasses (POACEAE). The sclerotia contain several toxic alkaloids. Claviceps purpurea on rye causes ergotism.Genetic Loci: Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.MSX1 Transcription Factor: A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Wnt Proteins: Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.Spirulina: A genus of filamentous CYANOBACTERIA found in most lakes and ponds. It has been used as a nutritional supplement particularly due to its high protein content.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Boraginaceae: The Borage plant family is in the class Magnoliopsida, subclass Asteridae, order Lamiales. It is characterized by hairy foliage, usually alternate and simple; flowers are funnel-shaped or tubular. Some of the species contain PYRROLIZIDINE ALKALOIDS.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Pentanones: 5-carbon straight-chain or branched-chain ketones.Lactams: Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.Cinnamomum zeylanicum: The tree which is known for its bark which is sold as cinnamon. The oil contains about 65-80% cinnamaldehyde and 10% EUGENOL and many TERPENES.KetonesAlchemyStreptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Streptomyces griseus: An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.Streptomyces coelicolor: A soil-dwelling actinomycete with a complex lifecycle involving mycelial growth and spore formation. It is involved in the production of a number of medically important ANTIBIOTICS.Streptomyces lividans: An actinomycete used for production of commercial ANTIBIOTICS and as a host for gene cloning.Antiparasitic Agents: Drugs used to treat or prevent parasitic infections.Streptomyces antibioticus: An actinomycete from which the antibiotic OLEANDOMYCIN is obtained.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.History, 20th Century: Time period from 1901 through 2000 of the common era.
(1/173) Thermoregulation of N-acyl homoserine lactone-based quorum sensing in the soft rot bacterium Pectobacterium atrosepticum.

The psychrotolerant bacterium Pectobacterium atrosepticum produces four N-acyl homoserine lactones under a wide range of temperatures. Their thermoregulation differs from that of the exoenzyme production, described as being under quorum-sensing control. A mechanism involved in this thermoregulation consists of controlling N-acyl homoserine lactones synthase production at a transcriptional level.  (+info)

(2/173) The plant pathogen Pantoea ananatis produces N-acylhomoserine lactone and causes center rot disease of onion by quorum sensing.

A number of gram-negative bacteria have a quorum-sensing system and produce N-acyl-l-homoserine lactone (AHL) that they use them as a quorum-sensing signal molecule. Pantoea ananatis is reported as a common colonist of wheat heads at ripening and causes center rot of onion. In this study, we demonstrated that P. ananatis SK-1 produced two AHLs, N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxohexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). We cloned the AHL-synthase gene (eanI) and AHL-receptor gene (eanR) and revealed that the deduced amino acid sequence of EanI/EanR showed high identity to those of EsaI/EsaR from P. stewartii. EanR repressed the ean box sequence and the addition of AHLs resulted in derepression of ean box. Inactivation of the chromosomal eanI gene in SK-1 caused disruption of exopolysaccharide (EPS) biosynthesis, biofilm formation, and infection of onion leaves, which were recovered by adding exogenous 3-oxo-C6-HSL. These results demonstrated that the quorum-sensing system involved the biosynthesis of EPS, biofilm formation, and infection of onion leaves in P. ananatis SK-1.  (+info)

(3/173) Theoretical study of molecular determinants involved in signal binding to the TraR protein of Agrobacterium tumefaciens.

N-acylated homoserine lactone (AHL) mediated cell-cell communication in bacteria is dependent on the recognition of the cognate signal by its receptor. This interaction allows the receptor-ligand complex to act as a transcriptional activator, controlling the expression of a range of bacterial phenotypes, including virulence factor expression and biofilm formation. One approach to determine the key features of signal- binding is to model the intermolecular interactions between the receptor and ligand using computational-based modeling software (LigandFit). In this communication, we have modeled the crystal structure of the AHL receptor protein TraR and its AHL signal N-(3- oxooctanoyl)-homoserine lactone from Agrobacterium tumefaciens and compared it to the previously reported antagonist behaviour of a number of AHL analogues, in an attempt to determine structural constraints for ligand binding. We conclude that (i) a common conformation of the AHL in the hydrophobic and hydrophilic region exists for ligand-binding, (ii) a tail chain length threshold of 8 carbons is most favourable for ligand-binding affinity, (iii) the positive correlation in the docking studies could be used a virtual screening tool.  (+info)

(4/173) Production of acyl-homoserine lactone quorum-sensing signals is widespread in gram-negative Methylobacterium.

Members of Methylobacterium, referred as pink-pigmented facultative methylotrophic bacteria, are frequently associated with terrestrial and aquatic plants, tending to form aggregates on the phyllosphere. We report here that the production of autoinducer molecules involved in the cell-to-cell signaling process, which is known as quorum sensing, is common among Methylobacterium species. Several strains of Methylobacterium were tested for their ability to produce N-acyl-homoserine lactone (AHL) signal molecules using different indicators. Most strains of Methylobacterium tested could elicit a positive response in Agrobacterium tumefaciens harboring lacZ fused to a gene that is regulated by autoinduction. The synthesis of these compounds was cell-density dependent, and the maximal activity was reached during the late exponential to stationary phases. The bacterial extracts were separated by thin-layer chromatography and bioassayed with A. tumefaciens NT1 (traR, tra::lacZ749). They revealed the production of various patterns of the signal molecules, which are strain dependent. At least two signal molecules could be detected in most of the strains tested, and comparison of their relative mobilities suggested that they are homologs of N-octanoyl-DL-homoserine lactone (C8-HSL) and N-decanoyl-DL-homoserine lactone (C10-HSL).  (+info)

(5/173) The acyl-homoserine lactone-type quorum-sensing system modulates cell motility and virulence of Erwinia chrysanthemi pv. zeae.

Erwinia chrysanthemi pv. zeae is one of the Erwinia chrysanthemi pathovars that infects on both dicotyledons and monocotyledons. However, little is known about the molecular basis and regulatory mechanisms of its virulence. By using a transposon mutagenesis approach, we cloned the genes coding for an E. chrysanthemi pv. zeae synthase of acyl-homoserine lactone (AHL) quorum-sensing signals (expI(Ecz)) and a cognate response regulator (expR(Ecz)). Chromatography analysis showed that expI(Ecz) encoded production of the AHL signal N-(3-oxo-hexanoyl)-homoserine lactone (OHHL). Null mutation of expI(Ecz) in the E. chrysanthemi pv. zeae strain EC1 abolished AHL production, increased bacterial swimming and swarming motility, disabled formation of multicell aggregates, and attenuated virulence of the pathogen on potato tubers. The mutation also marginally reduced the inhibitory activity of E. chrysanthemi pv. zeae on rice seed germination. The mutant phenotypes were rescued by either exogenous addition of AHL signal or in trans expression of expI(Ecz). These data demonstrate that the AHL-type QS signal plays an essential role in modulation of E. chrysanthemi pv. zeae cell motility and the ability to form multicell aggregates and is involved in regulation of bacterial virulence.  (+info)

(6/173) Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa.

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(7/173) Inter-kingdom signalling: communication between bacteria and their hosts.

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(8/173) Characteristics of the LrhA subfamily of transcriptional regulators from Sinorhizobium meliloti.

In our previous work, we identified 94 putative genes encoding LysR-type transcriptional regulators from Sinorhizobium meliloti. All of these putative lysR genes were mutagenized using plasmid insertions to determine their phenotypes. Six LysR-type regulators, encoded by mutants SMa1979, SMb20715, SMc00820, SMc04163, SMc03975, and SMc04315, showed similar amino acid sequences (30%) and shared the conserved DNA-binding domain with LrhA, HexA, or DgdR. Phenotype analysis of these gene mutants indicated that the regulators control the swimming behaviors of the bacteria, production of quorum-sensing signals, and secretion of extracellular proteins. These characteristics are very similar to those of LrhA, HexA, and DgdR. Thus, we refer to this group as the LrhA subfamily. Sequence analysis showed that a great number of homologous genes of the LrhA subfamily were distributed in the alpha, beta, and gamma subdivisions of proteobacteria, and a few in actinobacteria. These findings could provide new clues to the roles of the LysR gene family.  (+info)

The flow chart of extraction, detection, purification a | Open-i  The flow chart of extraction, detection, purification a | Open-i
Acyl-Butyrolactones/chemistry*/classification/isolation & purification*. *Bacterial Physiological Phenomena*. *Gram-Negative ... Extraction, purification and identification of bacterial signal molecules based on N-acyl homoserine lactones. ... Extraction, purification and identification of bacterial signal molecules based on N-acyl homoserine lactones. ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3815260_mbt0004-0479-f1&req=4
Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry<...  Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry<...
Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ...
more infohttps://squ.pure.elsevier.com/en/publications/malyngolide-from-the-cyanobacterium-lyngbya-majuscula-interferes-
Medicine, Medical Sciences & Nutrition - Research Output
     - The University of Aberdeen  Medicine, Medical Sciences & Nutrition - Research Output - The University of Aberdeen
Collins, F. L., Schepper, J. D., Rios-Arce, N. D., Steury, M. D., Kang, H. J., Mallin, H., Schoenherr, D., Camfield, G., Chishti, S., McCabe, L. R. & Parameswaran, N., 2017, Understanding the Gut-Bone Signaling Axis: Mechanisms and Therapeutic Implications. McCabe, L. R. & Parameswaran, N. (eds.). Cham: Springer , p. 59-94 36 p. (Advances in Experimental Medicine and Biology; vol. 1033).. Research output: Chapter in Book/Report/Conference proceeding › Chapter ...
more infohttps://abdn.pure.elsevier.com/en/organisations/medicine-medical-sciences-nutrition-3/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontobookanthology%2Fchapter
Unusual comQXPA-like loci.(A) Non-canonical unusual com | Open-i  Unusual comQXPA-like loci.(A) Non-canonical unusual com | Open-i
Unusual comQXPA-like loci.(A) Non-canonical unusual com system is present in B. cereus VD102, B. cereus BAG4X12 1, B. cereus MSX A1 and L. fusiformis ZC1. Note
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4008528_pone.0096122.g004&req=4
NAVER Academic > Search...  NAVER Academic > Search...
Acyl-Butyrolactones, chemistry, metabolism, Bacterial Proteins, genetics, Biofilms, Gene Expression Regulation, Bacterial, ...
more infohttps://academic.naver.com/search.naver?field=3&query=Folia+Microbiologica+57%EA%B6%8C+1%ED%98%B8
Lactones
     Summary Report | CureHunter  Lactones Summary Report | CureHunter
Acyl-Butyrolactones: 14. *mycolactone A: 13. *phospholine: 13. *ebelactone B: 12. *ginkgolide A: 12 ...
more infohttp://www.curehunter.com/public/keywordSummaryD007783-Lactones.do
Eriks Rozners - Publications  Eriks Rozners - Publications
Xu, Q.; Rozners,* E. Asymmetric Synthesis of trans-3,4-Dialkyl-γ-butyrolactones via an Acyl-Claisen and Iodolactonization Route ... Vedejs*, E.; Daugulis, O.; MacKay, J. A.; Rozners, E. Enantioselective Acyl Transfer Using Chiral Phosphine Catalysts. Synlett ...
more infohttp://chemiris.chem.binghamton.edu/ROZNERS/Publications.html
Novel Reporter for Identification of Interference with Acyl Homoserine Lactone and Autoinducer-2 Quorum Sensing | Applied and...  Novel Reporter for Identification of Interference with Acyl Homoserine Lactone and Autoinducer-2 Quorum Sensing | Applied and...
... gamma-butyrolactones and alpha-(N-alkyl-sulfonamide)-gamma-butyrolactones. Bioorg Med Chem Lett 21:6876-6879. doi:10.1016/j. ... Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus. J Bacteriol 182:6921-6926. doi:10.1128/JB ... Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infect Immun 74:1673-1682. doi: ... Multiple N-acyl-l-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri. J ...
more infohttps://aem.asm.org/content/81/4/1477
The Renaissance of -Methylene--butyrolactones  New Synthetic Approaches.  The Renaissance of -Methylene--butyrolactones New Synthetic Approaches.
Thermolysis of selenocarbonate 224 in benzene at 80 8C generated the corresponding acyl radical, which underwent cyclization to ... butyrolactones Chemie The amount of research activity concerning a-methylene-g-butyrolactones and a-alkylidene-g-butyrolactones ... Traditional approaches to a-methylene-g-butyrolactones and a-alkylidene-g-butyrolactones are then reviewed together with novel ... Other a-Alkylidene-g-butyrolactones A large number of non-terpenoid, naturally occurring aalkylidene-g-butyrolactones are also ...
more infohttps://www.docme.ru/doc/1941782/the-renaissance-of--methylene--butyrolactones--new-synthe..
Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species | Applied and Environmental Microbiology  Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species | Applied and Environmental Microbiology
... some gram-positive bacteria produce γ-butyrolactones as quorum-sensing signals, which are structurally quite similar to AHLs ( ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ...
more infohttps://aem.asm.org/content/68/4/1754?ijkey=0f8ed3d08863d1dbb1c54bb72ec530b7121afc1f&keytype2=tf_ipsecsha
ASMscience | Antibiotics  ASMscience | Antibiotics
The hydrophobic side chain of the butyrolactones, known generically also as butaneolides, is in the same locus as the N-acyl ... In the case of mycosubtilin, the first five domains of the MycA subunit are dedicated to construction of the C16-β-NH2-acyl ... The N-acylhomoserine lactones of Erwinia, Pseudomonas, and many other bacteria and the γ-butyrolactones of streptomycetes, ... in which all 10 of the ketone groups are thought to persist without reductive modification in the acyl chain. The first cyclase ...
more infohttp://www.asmscience.org/content/book/10.1128/9781555817886
Items by Bull, Steven - Opus  Items by Bull, Steven - Opus
N-acyl 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) tetraphenylborate salts as O-acylating agents. Tetrahedron Letters. , 53 (32), pp ... Dihydroxylation-based approach for the asymmetric syntheses of hydroxy-gamma-butyrolactones. Journal of Organic Chemistry. , 77 ... SuperQuat N-acyl-5,5-dimethyloxazolidin-2-ones for the asymmetric synthesis of alpha-alkyl and beta-alkyl aldehydes. Organic ... N -acyl DBN tetraphenylborate salts as N -acylating agents. Journal of Organic Chemistry. , 77 (6), pp. 2808-2818. ...
more infohttp://opus.bath.ac.uk/view/person_id/981.default.html
NHC Organocatalytic Formal LUMO Activation of α,β-Unsaturated Esters for Reaction with Enamides  - Cheng - 2013 - Angewandte...  NHC Organocatalytic Formal LUMO Activation of α,β-Unsaturated Esters for Reaction with Enamides - Cheng - 2013 - Angewandte...
Changhe Zhang, Joel F. Hooper, David W. Lupton, N-Heterocyclic Carbene Catalysis via the α,β-Unsaturated Acyl Azolium, ACS ... Enantioselective synthesis of spiro γ-butyrolactones by N-heterocyclic carbene (NHC)-catalyzed formal [3 + 2] annulation of ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/anie.201303247/full
Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access...  Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access...
Domingo, L. R., Saez, J. A., Arno, M. A DFT study on the NHC catalysed Michael addition of enols to α,β-unsaturated acyl- ... Dunn, M. H., Cole, M. L., Harper, J. B. Effects of an ionic liquid solvent on the synthesis of [gamma]-butyrolactones by ... Vora, H. U., Wheeler, P., Rovis, T. Exploiting acyl and enol azolium intermediates via N-hetero- cyclic carbene-catalyzed ...
more infohttps://www.jove.com/video/53213/sntese-altamente-stereoselective-de-16-cetosteres-mediada-por-lquidos?language=Portuguese
Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access...  Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access...
Domingo, L. R., Saez, J. A., Arno, M. A DFT study on the NHC catalysed Michael addition of enols to α,β-unsaturated acyl- ... Dunn, M. H., Cole, M. L., Harper, J. B. Effects of an ionic liquid solvent on the synthesis of [gamma]-butyrolactones by ... Vora, H. U., Wheeler, P., Rovis, T. Exploiting acyl and enol azolium intermediates via N-hetero- cyclic carbene-catalyzed ...
more infohttps://www.jove.com/video/53213/sntesis-altamente-estereoselectiva-de-16-cetosteres-mediada-por?language=Spanish
Publications  Publications
An acyl-CoA dehydrogenase is involved in the formation of the Dcis3 double bond in the acyl residue of the lipopeptide ... ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones. ...
more infohttps://uni-tuebingen.de/en/faculties/faculty-of-science/departments/interfaculty-facilities/imit/research-groups/microbiology-biotechnology/publications/
Applications filed at Dec 08 2011 | CHEMICAL SYNTHESIS OF A HIGHLY POTENT EPOTHILONE | Patents.com  Applications filed at Dec 08 2011 | CHEMICAL SYNTHESIS OF A HIGHLY POTENT EPOTHILONE | Patents.com
Compounds represented by the formula 1: ##STR00001## wherein each R individually is H, an aliphatic acyl group or an aromatic ... The present invention involves new and original sigma receptors Ligands: (Mono-or dialkylaminoalkyl)-.gamma.-butyro-lactones, ... acyl group; A is selected from the... 2011/0301164. METHOD OF ADMINISTERING OPHTHALMIC FLUIDS. A method is provided of treating ...
more infohttp://patents.com/ap-20111208-p31.html
ASMscience | Chemical Communication a  ASMscience | Chemical Communication a
... and acyl-acyl carrier protein (acyl-ACP). Enzymatic synthesis of AHLs using purified substrates for TraI (from Agrobacterium ... AfsA is thus the key enzyme for the biosynthesis of γ-butyrolactones. Interestingly, a database search predicts that afsA and ... The LasI structure provided a less clear explanation for the selectivity of AHL synthases for acyl-ACPs with long acyl chains. ... acyl-HSL)-controlled gene expression. In P. aeruginosa, quorum-sensing gene regulation is accomplished by two complete acyl-HSL ...
more infohttp://www.asmscience.org/content/book/10.1128/9781555815578
SMART: Secondary literature for Trans reg C domain  SMART: Secondary literature for Trans reg C domain
FadR is a dimeric acyl coenzyme A (acyl CoA)-binding protein andtranscription factor that regulates the expression of genes ... Many streptomycetes produce extracellular gamma-butyrolactones. In severalcases, these have been shown to act as signals for ... The structure reveals a dimer and atwo-domain fold, with DNA-binding and acyl-CoA-binding sites located in anN-terminal and C- ... Crystal structure of FadR, a fatty acid-responsive transcription factorwith a novel acyl coenzyme A-binding fold. ...
more infohttp://smart.embl.de/smart/show_secondary.cgi?domain=Trans_reg_C
  • in addition to reports describing the isolation of a-methylene- and a-alkylidene-g-butyrolactones, there have been numerous publications covering their biosynthesis, biological properties, and medical applications. (docme.ru)
  • 21. Knochel P.*, Yeh M.C.P., Berk S.C., Talbert J., "Synthesis and Reactivity Toward Acyl chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI" J. Org. (uni-muenchen.de)