4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.Acyl Coenzyme A: S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.Acylation: The addition of an organic acid radical into a molecule.Quorum Sensing: A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.Chitosan: Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.Acyl-Butyrolactones: Cyclic esters of acylated BUTYRIC ACID containing four carbons in the ring.HomoserineChromobacterium: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria occurring in soil and water. Its organisms are generally nonpathogenic, but some species do cause infections of mammals, including humans.Lactones: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)IllinoisPsychology, Experimental: The branch of psychology which seeks to learn more about the fundamental causes of behavior by studying various psychologic phenomena in controlled experimental situations.National Socialism: The doctrines and policies of the Nazis or the National Social German Workers party, which ruled Germany under Adolf Hitler from 1933-1945. These doctrines and policies included racist nationalism, expansionism, and state control of the economy. (from Columbia Encyclopedia, 6th ed. and American Heritage College Dictionary, 3d ed.)Bland White Garland Syndrome: A congenital coronary vessel anomaly in which the left main CORONARY ARTERY originates from the PULMONARY ARTERY instead of from AORTA. The congenital heart defect typically results in coronary artery FISTULA; LEFT-SIDED HEART FAILURE and MITRAL VALVE INSUFFICIENCY during the first months of life.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Pseudomonas syringae: A species of gram-negative, fluorescent, phytopathogenic bacteria in the genus PSEUDOMONAS. It is differentiated into approximately 50 pathovars with different plant pathogenicities and host specificities.Siderophores: Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Plant Diseases: Diseases of plants.Oligopeptides: Peptides composed of between two and twelve amino acids.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Lycopersicon esculentum: A plant species of the family SOLANACEAE, native of South America, widely cultivated for their edible, fleshy, usually red fruit.Bacillus cereus: A species of rod-shaped bacteria that is a common soil saprophyte. Its spores are widespread and multiplication has been observed chiefly in foods. Contamination may lead to food poisoning.Claviceps: A genus of ascomycetous fungi, family Clavicipitaceae, order Hypocreales, parasitic on various grasses (POACEAE). The sclerotia contain several toxic alkaloids. Claviceps purpurea on rye causes ergotism.Genetic Loci: Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.MSX1 Transcription Factor: A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Wnt Proteins: Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.Spirulina: A genus of filamentous CYANOBACTERIA found in most lakes and ponds. It has been used as a nutritional supplement particularly due to its high protein content.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Pentanones: 5-carbon straight-chain or branched-chain ketones.Bence Jones Protein: An abnormal protein with unusual thermosolubility characteristics that is found in the urine of patients with MULTIPLE MYELOMA.New YorkDrugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Bryopsida: A class of plants within the Bryophyta comprising the mosses, which are found in both damp (including freshwater) and drier situations. Mosses possess erect or prostrate leafless stems, which give rise to leafless stalks bearing capsules. Spores formed in the capsules are released and grow to produce new plants. (Concise Dictionary of Biology, 1990). Many small plants bearing the name moss are in fact not mosses. The "moss" found on the north side of trees is actually a green alga (CHLOROPHYTA). Irish moss is really a red alga (RHODOPHYTA). Beard lichen (beard moss), Iceland moss, oak moss, and reindeer moss are actually LICHENS. Spanish moss is a common name for both LICHENS and an air plant (TILLANDSIA usneoides) of the pineapple family. Club moss is an evergreen herb of the family LYCOPODIACEAE.Lauraceae: A family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.Ectromelia: Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, phocomelia, and sirenomelia.Saint Vincent and the Grenadines: A self-governing state of the Windward Islands in the West Indies, comprising Saint Vincent and the northern islets of the Grenadines. Its capital is Kingstown. It is one of the original homes of the Carib Indians supposed to have been sighted by Columbus in 1498. It was in English hands from 1627 till held by the French 1779-83. Saint Vincent subsequently became a British possession and, with other nearby British territories, was administered by the Governor of the Windward Islands till 1959. It attained a measure of independence in 1969 but achieved full independence as Saint Vincent and the Grenadines in 1979. Saint Vincent was the 4th century Spanish martyr on whose feast day Columbus discovered the island. Grenadines is derived from the Spanish kingdom of Granada. (From Webster's New Geographical Dictionary, 1988, p1054 & The Europa World Year Book 1993, p2441)Nail Diseases: Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive: An autosomal recessive form of ectodermal dysplasia which is due to mutations in the gene for the EDAR RECEPTOR or EDAR-ASSOCIATED DEATH DOMAIN PROTEIN.BooksLiterature, ModernScalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).AlchemyStreptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Streptomyces griseus: An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.Streptomyces coelicolor: A soil-dwelling actinomycete with a complex lifecycle involving mycelial growth and spore formation. It is involved in the production of a number of medically important ANTIBIOTICS.Streptomyces lividans: An actinomycete used for production of commercial ANTIBIOTICS and as a host for gene cloning.Antiparasitic Agents: Drugs used to treat or prevent parasitic infections.Streptomyces antibioticus: An actinomycete from which the antibiotic OLEANDOMYCIN is obtained.

Thermoregulation of N-acyl homoserine lactone-based quorum sensing in the soft rot bacterium Pectobacterium atrosepticum. (1/173)

The psychrotolerant bacterium Pectobacterium atrosepticum produces four N-acyl homoserine lactones under a wide range of temperatures. Their thermoregulation differs from that of the exoenzyme production, described as being under quorum-sensing control. A mechanism involved in this thermoregulation consists of controlling N-acyl homoserine lactones synthase production at a transcriptional level.  (+info)

The plant pathogen Pantoea ananatis produces N-acylhomoserine lactone and causes center rot disease of onion by quorum sensing. (2/173)

A number of gram-negative bacteria have a quorum-sensing system and produce N-acyl-l-homoserine lactone (AHL) that they use them as a quorum-sensing signal molecule. Pantoea ananatis is reported as a common colonist of wheat heads at ripening and causes center rot of onion. In this study, we demonstrated that P. ananatis SK-1 produced two AHLs, N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxohexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). We cloned the AHL-synthase gene (eanI) and AHL-receptor gene (eanR) and revealed that the deduced amino acid sequence of EanI/EanR showed high identity to those of EsaI/EsaR from P. stewartii. EanR repressed the ean box sequence and the addition of AHLs resulted in derepression of ean box. Inactivation of the chromosomal eanI gene in SK-1 caused disruption of exopolysaccharide (EPS) biosynthesis, biofilm formation, and infection of onion leaves, which were recovered by adding exogenous 3-oxo-C6-HSL. These results demonstrated that the quorum-sensing system involved the biosynthesis of EPS, biofilm formation, and infection of onion leaves in P. ananatis SK-1.  (+info)

Theoretical study of molecular determinants involved in signal binding to the TraR protein of Agrobacterium tumefaciens. (3/173)

N-acylated homoserine lactone (AHL) mediated cell-cell communication in bacteria is dependent on the recognition of the cognate signal by its receptor. This interaction allows the receptor-ligand complex to act as a transcriptional activator, controlling the expression of a range of bacterial phenotypes, including virulence factor expression and biofilm formation. One approach to determine the key features of signal- binding is to model the intermolecular interactions between the receptor and ligand using computational-based modeling software (LigandFit). In this communication, we have modeled the crystal structure of the AHL receptor protein TraR and its AHL signal N-(3- oxooctanoyl)-homoserine lactone from Agrobacterium tumefaciens and compared it to the previously reported antagonist behaviour of a number of AHL analogues, in an attempt to determine structural constraints for ligand binding. We conclude that (i) a common conformation of the AHL in the hydrophobic and hydrophilic region exists for ligand-binding, (ii) a tail chain length threshold of 8 carbons is most favourable for ligand-binding affinity, (iii) the positive correlation in the docking studies could be used a virtual screening tool.  (+info)

Production of acyl-homoserine lactone quorum-sensing signals is widespread in gram-negative Methylobacterium. (4/173)

Members of Methylobacterium, referred as pink-pigmented facultative methylotrophic bacteria, are frequently associated with terrestrial and aquatic plants, tending to form aggregates on the phyllosphere. We report here that the production of autoinducer molecules involved in the cell-to-cell signaling process, which is known as quorum sensing, is common among Methylobacterium species. Several strains of Methylobacterium were tested for their ability to produce N-acyl-homoserine lactone (AHL) signal molecules using different indicators. Most strains of Methylobacterium tested could elicit a positive response in Agrobacterium tumefaciens harboring lacZ fused to a gene that is regulated by autoinduction. The synthesis of these compounds was cell-density dependent, and the maximal activity was reached during the late exponential to stationary phases. The bacterial extracts were separated by thin-layer chromatography and bioassayed with A. tumefaciens NT1 (traR, tra::lacZ749). They revealed the production of various patterns of the signal molecules, which are strain dependent. At least two signal molecules could be detected in most of the strains tested, and comparison of their relative mobilities suggested that they are homologs of N-octanoyl-DL-homoserine lactone (C8-HSL) and N-decanoyl-DL-homoserine lactone (C10-HSL).  (+info)

The acyl-homoserine lactone-type quorum-sensing system modulates cell motility and virulence of Erwinia chrysanthemi pv. zeae. (5/173)

Erwinia chrysanthemi pv. zeae is one of the Erwinia chrysanthemi pathovars that infects on both dicotyledons and monocotyledons. However, little is known about the molecular basis and regulatory mechanisms of its virulence. By using a transposon mutagenesis approach, we cloned the genes coding for an E. chrysanthemi pv. zeae synthase of acyl-homoserine lactone (AHL) quorum-sensing signals (expI(Ecz)) and a cognate response regulator (expR(Ecz)). Chromatography analysis showed that expI(Ecz) encoded production of the AHL signal N-(3-oxo-hexanoyl)-homoserine lactone (OHHL). Null mutation of expI(Ecz) in the E. chrysanthemi pv. zeae strain EC1 abolished AHL production, increased bacterial swimming and swarming motility, disabled formation of multicell aggregates, and attenuated virulence of the pathogen on potato tubers. The mutation also marginally reduced the inhibitory activity of E. chrysanthemi pv. zeae on rice seed germination. The mutant phenotypes were rescued by either exogenous addition of AHL signal or in trans expression of expI(Ecz). These data demonstrate that the AHL-type QS signal plays an essential role in modulation of E. chrysanthemi pv. zeae cell motility and the ability to form multicell aggregates and is involved in regulation of bacterial virulence.  (+info)

Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa. (6/173)

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Inter-kingdom signalling: communication between bacteria and their hosts. (7/173)

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Characteristics of the LrhA subfamily of transcriptional regulators from Sinorhizobium meliloti. (8/173)

In our previous work, we identified 94 putative genes encoding LysR-type transcriptional regulators from Sinorhizobium meliloti. All of these putative lysR genes were mutagenized using plasmid insertions to determine their phenotypes. Six LysR-type regulators, encoded by mutants SMa1979, SMb20715, SMc00820, SMc04163, SMc03975, and SMc04315, showed similar amino acid sequences (30%) and shared the conserved DNA-binding domain with LrhA, HexA, or DgdR. Phenotype analysis of these gene mutants indicated that the regulators control the swimming behaviors of the bacteria, production of quorum-sensing signals, and secretion of extracellular proteins. These characteristics are very similar to those of LrhA, HexA, and DgdR. Thus, we refer to this group as the LrhA subfamily. Sequence analysis showed that a great number of homologous genes of the LrhA subfamily were distributed in the alpha, beta, and gamma subdivisions of proteobacteria, and a few in actinobacteria. These findings could provide new clues to the roles of the LysR gene family.  (+info)

Author Summary The human pathogen Pseudomonas aeruginosa and other bacteria communicate with each other using quorum sensing (QS). This is important for their growth, virulence, motility and the formation of biofilms. Furthermore, eukaryotic cells
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Implications for the application of the MPN technique.It has been shown that cellular isolates which correspond to abundant 16S rDNA sequences can indeed be isolated if the inocula are diluted in MPN series prior to enrichment (16). This effect has been attributed to the presence of rare but rapidly growing bacteria which are eliminated by the dilution step. Consequently, the MPN technique currently represents the method of choice to obtain cultures of abundant bacteria (16).. Unexpectedly, isolates obtained in the present study from the highest positive dilutions, despite the very high cultivation success of up to 100%, could not be detected by DGGE fingerprinting and yielded only a very faint signal during dot blot hybridization. Based on the relatively large inherent statistical uncertainty of the MPN technique, the fraction of strain G100 in the natural bacterioplankton community could also be as low as 12% (the lower limit of the MPN confidence interval). Nevertheless, this minimum value is ...
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Specific recognition of cognate signals is considered fundamental to cell signaling circuits as it creates fidelity in the communication system. In bacterial quorum sensing (QS), receptor specificity ensures that bacteria cooperate only with kin. There are examples, however, of QS receptors that respond promiscuously to multiple signals. "Eavesdropping" by these promiscuous receptors can be beneficial in both interspecies competition... ...
Bacterial cell-to-cell signalling has emerged as a new area in microbiology. Individual bacterial cells communicate with each other and co-ordinate group activities. Although a lot of detail is known about the mechanisms of a few well-characterized bacterial communication systems, other systems have …
Virulence in the Gram-negative pathogen Pseudomonas aeruginosa relies in part on the efficient functioning of two LuxI/R dependent quorum sensing (QS) cascades, namely, the LasI/R and RhlI/R systems that generate and respond to N-(3-oxo)-dodecanoyl-l-homoserine lactone and N-butyryl-l-homoserine lactone, respectively. The two acyl homoserine lactone (AHL) synthases, LasI and RhlI, use 3-oxododecanoyl-ACP and butyryl-ACP, respectively, as the acyl-substrates to generate the corresponding autoinducer signals for the bacterium. Although AHL synthases represent excellent targets for developing QS modulators in P. aeruginosa, and in other related bacteria, the identification of potent and signal synthase specific inhibitors has represented a significant technical challenge. In the current study, we sought to test the utility of AHL analogs as potential modulators of an AHL synthase and selected RhlI in P. aeruginosa as an initial target. We systematically varied the chemical functionalities of the ...
A number of bacteria use a class of chemical compounds called acyl-homoserine lactones (AHLs) as quorum sensing (QS) signals to coordinate their behavior at the population level, including pathogens...
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The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Accepted name: acyl-homoserine-lactone acylase. Reaction: an N-acyl-L-homoserine lactone + H2O = L-homoserine lactone + a carboxylate. Other name(s): acyl-homoserine lactone acylase; AHL-acylase; AiiD; N-acyl-homoserine lactone acylase; PA2385 protein; quorum-quenching AHL acylase; quorum-quenching enzyme; PvdQ; QuiP. Systematic name: N-acyl-L-homoserine-lactone amidohydrolase. Comments: Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This ...
Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones (Cynthia H. Collins, Frances H. Arnold and Jared R. Leadbetter) Molecular Microbiology 2005 Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes (Yi-Han Lin, Jin-Ling Xu, Jiangyong Hu, Lian-Hui Wang, Say Leong, Jared Renton Leadbetter and Lian-Hui Zhang) Molecular Microbiology 2003 Quorum Sensing and Quorum-quenching enzymes (Yi-Hu Dong and Lian-Hui Zhang) Journal of Microbiology 2005 AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria (Park, et. al) Microbiology 2003 AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora PNAS 2000 The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase (Kim et al.) PNAS 2005 Communications blackout? Do ...
Some bacteria use pheromones (N-acylhomoserine lactones or AHLs) to determine their population density. Salmonella does not make AHLs but it can detect the AHLs produced by other bacteria. We hypothesized that Salmonella would detect AHLs made by the normal intestinal flora and use this information to adjust its gene expression accordingly. Surprisingly, we discovered that the normal gut flora does not make AHLs and instead, Salmonella is detecting the AHL production of other pathogens in the gut. Salmonella can detect the AHL production of Aeromonas hydrophila in turtles and Yersinia enterocolitica in mice. We are characterizing this same AHL detection system in E. coli, Klebsiella, Enterobacter and other closely related organisms.. 2. Coordination of metabolism and virulence by SirA and CsrA ...
Functional polymers that selectively recognize target compounds are developed by imprinting polymerization. In the present paper, two different dipyrromethanes, 5-phenol-dipyrromethane (5-pOH-DP) and 5-phenyl-dipyrromethane (5-ph-DP), are synthetized and investigated to develop conductive molecularly imprinted polymer (cMIP) sensors. As target molecules, two homoserine lactone derivatives were templated by an electrochemically driven polymerization process. Acyl-homoserine lactones (AHLs), also called homoserine lactones (HS), are a class of signaling molecules involved in bacterial quorum sensing (QS), which is a strategy of coordination among bacteria mediated by population density. The preparation of cMIP from 5-pOH-DP and 5-ph-DP in the presence of acetyl-homoserine lactone (Acetyl-HS) or carboxybenzyl-homoserine lactone (Cbz-HS) was performed by cyclic voltammetry (CV). The cMIP selectivity and sensitivity were assessed by microgravimetry (QCM). Both series of measurements were performed with the
Sigma-Aldrich offers abstracts and full-text articles by [Danielle M Stacy, Michael A Welsh, Philip N Rather, Helen E Blackwell].
Most studies of biofilms have focused on single species and on genes that control or are regulated by life on a surface. As more information is uncovered by studies of pure cultures, these data can be applied towards understanding the roles of specific genes in multispecies interactions. This chapter focuses mostly on multi-species interactions among oral bacteria in biofilms: a few single-species biofilms are featured to discuss responses to environmental signals, including signals generated by the occupants within the biofilm. Signals involved in cell-to-cell communication among biofilm cells include acyl homoserine lactones, oligopeptides, and autoinducer-2 (AI-2). Importantly, an optimal concentration of 4,5-dihydroxy-2,3-pentanedione (DPD) was critical for maximal biofilm development. One site where natural multispecies biofilms are unusually accessible is the tooth surface in the human oral cavity. We use a retrievable enamel chip model system that permits us to place three pieces of enamel side
The presence of charcoal in soil triggers a range of biological effects that are not yet predictable, in part because it interferes with the functioning of chemical signals that microbes release into their environment to communicate. We do not fully understand the mechanisms by which charcoal alters the biologically available concentrations of these intercellular signals. Recently, charcoal has been shown to sorb the signaling molecules that microbes release, rendering them ineffective for intercellular communication. Here, we investigate a second, potentially more important mechanism of interference: signaling-molecule hydrolysis driven by charcoal-induced soil pH changes. We examined the effects of 10 charcoals on the bioavailable concentration of an acyl-homoserine lactone (AHL) used by many Gram-negative bacteria for cell-cell communication. We show that charcoals decrease the level of bioavailable AHL through sorption and pH-dependent hydrolysis of the lactone ring. We then built a ...
One major microbiological problem is the widespread antibiotic resistance. There is an urgent need for new antibiotics and ways to treat multi-drug-resistant infections. Inhibition of bacterial quorum sensing (QS) systems could be an effective alternative in a smuch as they regulate a broad spectrum of cell functions, including, virulence factor production, biofilm organisation and motility. Influx and efflux bacterial systems involved in quorum sensing (QS) are known to depend on the proton motive force (PMF). Thus, a new series of 12 trifluoromethyl ketones (TFs) known to inhibit the PMF, was investigated for effects on the efflux pump of a QS responding bacterium, for its subsequent effect on the response to a QS signal and its direct inhibition of the response to a QS signal ...
Our project harnesses the use of quorum sensing to prevent bacteria from activating pathogenic factors triggered by AHLs. We developed a model system with Allivibrio fisheri. A. fisheri luminesces when activated by AHLs, which is a much safer alternative to pathogenic bacteria. We grew up our E. coli with Vibrio fisheri, and showed that the recombinant E. coli could detect V. fisheris AHLs, and inhibit V. fisheri from activating its quorum response genes by not producing light.The detection system then secretes factors that reduce the concentration of AHLs in the environment, thereby inhibiting the bacteria that use AHLs from communicating with each other. This is useful in preventing pathology from bacteria. When a threshold level of AHLs is reached in pathogenic bacteria, the signals activate transcription of pathogenic factors such as biofilm formation and host invasion signals (Raffa et al, 2005). We propose that disrupting the AHLs will inhibit these bacteria from creating biofilms or ...
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During this shaking period label chloroform-resistant tubes or 96 well plate with sample names and dilutions For ease of handling large numbers of eppendorf tubes, we load them in a rack, wrap saran wrap around the tubes + rack, secure the ends with packing tape, and shake the entire rack in the 37°C shaker. Saran wrap can be easily cut off using scissors at the end of the experiment ...
4G8D: High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism for N-acyl homoserine lactonase
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Thuajse të gjithëve iu ka ndodhur që teksa pastrojnë kungullin i flakin edhe farat. Por farat kanë veti shumë të dobishme për shëndetin e njeriut dhe jan
Maryam Ebadi, Haniyeh Akhlaghi, Mohammad Mahdi Zamani, Hani Beheshti, Hassan Abolhassani, Ahmad Ayadi, Jaleh Dezdar, Seyedeh Hamideh Mortazzavi, Gholam Reza Karami, Morteza Izadi ...
TY - JOUR. T1 - N-acyl-L-homoserine lactones are inter-kingdom signalling molecules controlling quorum sensing in the Gram-negative bacteria and priming plants increasing stress adaptation. AU - Moshynets, O.. AU - Babenko, L.. AU - Karakhim, S.. AU - Kharkhota, M.. AU - Kosakivska, I.. AU - Rogalsky, S.. AU - Shcherbatiuk, M.. AU - Suslova, O.. AU - Spiers, A.. PY - 2017/9. Y1 - 2017/9. U2 - 10.1111/febs.14174. DO - 10.1111/febs.14174. M3 - Meeting Abstract. VL - 284. SP - 358. EP - 358. JO - FEBS Journal. JF - FEBS Journal. SN - 1742-464X. IS - S1. T2 - 42nd Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back. Y2 - 10 September 2017 through 14 September 2017. ER - ...
New approaches to deal with drug-resistant pathogenic bacteria are urgent. We studied the antibacterial effect of chitosans against an |i|Escherichia coli|/i| quorum sensing biosensor reporter strain and selected a non-toxic chitosan to evaluate its quorum sensing (QS) inhibition activity and its ef …
The recent rapid growth in the biofilm field has spawned a number of new strategies for controlling biofilms. Below are descriptions of a few of these emergent strategies.. For some years it has been known that bacteria communicate with each other via diffusible signal molecules in a process termed "quorum sensing." The discovery that quorum sensing regulates biofilm formation opens the door to interdicting normal biofilm development through the use of quorum sensing inhibitors. This strategy of jamming communication is now moving towards application. One example of such inhibitors are the brominated furanones that block quorum sensing by acyl homoserine lactones, signal molecules used by Gram-negative bacteria. These furanones were first isolated from a marine algae and are thought to be part of the plants natural defense against microbial biofouling. Furanone-based quorum sensing inhibitors have been shown to increase antibiotic sensitivity of Pseudomonas aeruginosa biofilms and improve ...
Bacteria can coordinate and synchronize activities through a cell density-dependent regulatory mechanism called quorum sensing (QS). Bacteria can measure their population by the synthesis, secretion, and perception of QS signal molecules to regulate specific gene expression when the population reaches a critical threshold. QS participates in various microbial processes such as marine organism bioluminescence, bacterial biofilm formation, and virulence factor expression. The use of QS systems mediated by N-acyl-homoserine lactones and autoinducer-2 has been recently recognized as a promising regulatory approach in environmental science and technology that can intrinsically promote the profound comprehension of wastewater treatment from a microbiology perspective ...
Many common bacterial pathogens use chemical signals to coordinate group behaviors. In the canonical quorum sensing (QS) system of V. fischeri, a synthase, LuxI, produces an N-acyl homoserine lactone (AHL) that is recognized by a receptor, LuxR, at high signal density. LuxR is a transcription factor that regulates bioluminescence and other group behaviors at high population density in an AHL dependent manner. SdiA is a LuxR homolog found in Escherichia coli and Salmonella enterica serovar typhimurium. SdiA does not have a corresponding synthase, however, and these species do not produce AHL signals. SdiA does not respond to population density, but rather has been shown to respond to AHLs produced by other bacterial species in its environment. SdiA regulates many aspects of pathogenesis including directing the location of the infection, survival in the mammalian digestive system, and the production of virulence factors. Accordingly, modulation of SdiA activity might be a useful anti-virulence ...
The goal of this project is to decipher the quorum sensing (cell-to-cell signaling) abilities of Shewanella oneidensis MR-1, a Gram-negative bacterium well known for its ability to use geologic substrates, such as Fe and Mn oxides, for respiratory purposes. Overall our results show that S. oneidensis cannot utilize either an acyl-homoserine lactone (AHL) or AI-2 quorum sensing signal, despite previous work that indicated that it produced an AHL that would enhance it ability to growth in certain anaerobic environments. Using a variety of quorum sensing signal sensors, no evidence could be found that S. oneidensis has a typical AHL signal. An in silco analysis of the genome also produced little evidence that S. oneidensis has the genes to accept or relay an AHL signal. S. oneidensis can produce a luminescence response in the AI-2 reporter strain, Vibrio harveyi MM32. This luminescence response is abolished upon deletion of luxS, the gene responsible for catalyzing AI-2. Deletion of luxS also ...
LuxI and LuxR are key factors that drive quorum sensing (QS) in bacteria through secretion and perception of the signaling molecules e.g. N-Acyl homoserine lactones (AHLs). The role of these proteins is well established in Gram-negative bacteria for intercellular communication but remain under-explored in Gram-positive bacteria where QS peptides are majorly responsible for cell-to-cell communication. Therefore, in the present study, we explored conservation, potential function, topological arrangements and evolutionarily aspects of these proteins in Gram-positive bacteria. Putative LuxI/LuxR containing proteins were retrieved using the domain-based strategy from InterPro v62.0 meta-database. Conservational analyses via multiple sequence alignment and domain showed that these are well conserved in Gram-positive bacteria and possess relatedness with Gram-negative bacteria. Further, Gene ontology and ligand-based functional annotation explain their active involvement in signal transduction ...
Many Gram-negative bacteria employ N-acylhomoserine lactones (AHLs) as quorum-sensing (QS) signal molecules to regulate virulence expression in a density-dependent manner. Quorum quenching (QQ) via enzymatic inactivation of AHLs is a promising strategy to reduce bacterial infections and drug resistance. Herein, a thermostable AHL lactonase (AidB), which could degrade different AHLs, with or without a substitution of carbonyl or hydroxyl at the C-3 position, was identified from the soil bacterium Bosea sp. strain F3-2. Ultrahigh-performance liquid chromatography analysis demonstrated that AidB is an AHL lactonase that hydrolyzes the ester bond of the homoserine lactone (HSL) ring. AidB was thermostable in the range 30 to 80°C and showed maximum activity after preincubation at 60°C for 30 min. The optimum temperature of AidB was 60°C, and the enzyme could be stably stored in double-distilled water (ddH2O) at 4°C or room temperature. AidB homologs were found only in Rhizobiales and ...
definition of HBHL, what does HBHL mean?, meaning of HBHL, Hydroxybutanoyl Homoserine Lactone, HBHL stands for Hydroxybutanoyl Homoserine Lactone
Recent studies have identified a novel interkingdom signaling circuit, via plant signaling molecules, and a bacterial sub-family of LuxR proteins, bridging eukaryotes and prokaryotes. Indeed pivotal plant-bacteria interactions are regulated by the so called Plant Associated Bacteria (PAB) LuxR solo regulators that, although closely related to the quorum sensing (QS) LuxR family, do not bind or respond to canonical quorum sensing N-acyl homoserine lactones (AHLs), but only to specific host plant signal molecules. The large body of structural data available for several members of the QS LuxR family complexed with different classes of ligands (AHLs and other compounds), has been exploited to dissect the cartography of their regulatory domains through structure-based multiple sequence alignments, structural superimposition and a comparative analysis of the contact residues involved in ligand binding. In the absence of experimentally determined structures of members of the PAB LuxR solos subfamily, an
Quorum sensing regulation, mediated by N-acyl homoserine lactone signals, produced by strain Serratia plymuthica HRO-C48 isolated from the rhizosphere of oilseed rape, was found to be responsible for
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CP001096.PE321 Location/Qualifiers FT CDS_pept complement(343120..343851) FT /codon_start=1 FT /transl_table=11 FT /locus_tag="Rpal_0323" FT /product="transcriptional regulator, LuxR family" FT /note="PFAM: regulatory protein LuxR; Autoinducer-binding FT domain protein; KEGG: bbt:BBta_7112 putative N-acyl FT homoserine lactone transcriptional regulator, LuxR-like FT protein" FT /db_xref="EnsemblGenomes-Gn:Rpal_0323" FT /db_xref="EnsemblGenomes-Tr:ACE98883" FT /db_xref="GOA:B3Q959" FT /db_xref="InterPro:IPR000792" FT /db_xref="InterPro:IPR005143" FT /db_xref="InterPro:IPR016032" FT /db_xref="InterPro:IPR036388" FT /db_xref="InterPro:IPR036693" FT /db_xref="UniProtKB/TrEMBL:B3Q959" FT /protein_id="ACE98883.1" FT /translation="MIVGEDQLWGRRALEFVDSVERLEAPALISRFESLIASCGFTAYI FT MAGLPSRNAGLPELTLANGWPRDWFDLYVSENFSAVDPVPRHGATTVYPFVWSDAPYDR FT DRDPAAHRVMTRAAEFGLVEGYCIPLHYDDGSAAISMAGKDPDLSPAARGAMQLVSIYA FT HSRLRALSRPKPIRRNRLTPRECEILQWAAQGKTAWEISVILCITERTVKFHLIEAARK FT LDAANRTAAVAKALTLGLIRL" atgatcgtcg ...
This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. You understand what makes a tissue specific and depict key signaling pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors.
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Z-D-Homoserine Lactone chemical properties, What are the chemical properties of Z-D-Homoserine Lactone 41088-89-5, What are the physical properties of Z-D-Homoserine Lactone ect.
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The black band disease (BBD) microbial consortium often causes mortality of reef-building corals. Microbial chemical interactions (i.e., quorum sensing (QS) and antimicrobial production) may be involved in the BBD disease process. Culture filtrates (CFs) from over 150 bacterial isolates from BBD and the surface mucopolysaccharide layer (SML) of healthy and diseased corals were screened for acyl homoserine lactone (AHL) and Autoinducer-2 (AI-2) QS signals using bacterial reporter strains. AHLs were detected in all BBD mat samples and nine CFs. More than half of the CFs (~55%) tested positive for AI-2. Approximately 27% of growth challenges conducted among 19 isolates showed significant growth inhibition. These findings demonstrate that QS is actively occurring within the BBD microbial mat and that culturable bacteria from BBD and the coral SML are able to produce QS signals and antimicrobial compounds. This is the first study to identify AHL production in association with active coral disease.
Quorum-quenching catalysts are of interest for potential application as biochemical tools for interrogating interbacterial communication pathways, as antibiofouling agents, and as anti-infective agents in plants and animals. Herein, the structure and function of AidC, an N-acyl-l-homoserine lactone (AHL) lactonase from Chryseobacterium, is characterized. Steady-state kinetics show that zinc-supplemented AidC is the most efficient wild-type quorum-quenching enzymes characterized to date, with a k cat/K M value of approximately 2 × 10 6 M -1 s -1 for N-heptanoyl-l-homoserine lactone. The enzyme has stricter substrate selectivity and significantly lower KM values (ca. 50 μM for preferred substrates) compared to those of typical AHL lactonases (ca. ,1 mM). X-ray crystal structures of AidC alone and with the product N-hexanoyl-l-homoserine were determined at resolutions of 1.09 and 1.67 Å, respectively. Each structure displays as a dimer, and dimeric oligiomerization was also observed in solution ...
In recent years it has become clear that the production of N-acyl homoserine lactones (N-AHLs) is widespread in Gram-negative bacteria. These molecules act as diffusible chemical communication signals (bacterial pheromones) which regulate diverse physiological processes including bioluminescence, antibiotic production, piasmid conjugal transfer and synthesis of exoenzyme virulence factors in plant and animal pathogens. The paradigm for N-AHL production is in the bioluminescence (lux) phenotype of Photobacterium fischeri (formerly classified as Vibrio fischeri) where the signalling molecule N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) is synthesized by the action of the Luxl protein. OHHL is thought to bind to the LuxR protein, allowing it to act as a positive transcriptional activator in an autoinduction process that physiologically couples cell density (and growth phase) to the expression of the bioluminescence genes. Based on the growing information on Luxl and LuxR homologues in other ...
Acyl-Butyrolactones / metabolism *. Actions. * Search in PubMed * Search in MeSH * Add to Search ... Assessment of the Quorum Sensing Inhibition Activity of a Non-Toxic Chitosan in an N-Acyl Homoserine Lactone (AHL)-Based ... Assessment of the Quorum Sensing Inhibition Activity of a Non-Toxic Chitosan in an N-Acyl Homoserine Lactone (AHL)-Based ... Beneficial Effects of Bacteria-Plant Communication Based on Quorum Sensing Molecules of the N-acyl Homoserine Lactone Group A ...
Acyl-Butyrolactones/chemistry*/classification/isolation & purification*. *Bacterial Physiological Phenomena*. *Gram-Negative ... Extraction, purification and identification of bacterial signal molecules based on N-acyl homoserine lactones. ... Extraction, purification and identification of bacterial signal molecules based on N-acyl homoserine lactones. ...
γ-Butyrolactones (GBLs). Streptomyces spp.. AfsA-type GBL synthase. Acyl-ACP, glycerol. ArpA-type repressor, GBL-binding ... Acyl homoserine lactones (AHLs). Proteobacteria LuxI-type enzymes. SAM, acyl-ACP. LuxR-type proteins. Diverse processes. 21 ... SAM, acyl-ACP, acyl-CoA. Two-component kinase. Linear oligopeptides. Gram-positive organisms. Genetically encoded (e.g., B. ... acyl-CoA?. RpfC, RpfH. Virulence and pigmentation. 100 4-Hydroxy-2-alkyl quinolines (PQS, HAQs). Pseudomonads. pqsABCDE, pqsH ...
... gamma-butyrolactones and alpha-(N-alkyl-sulfonamide)-gamma-butyrolactones. Bioorg Med Chem Lett 21:6876-6879. doi:10.1016/j. ... Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus. J Bacteriol 182:6921-6926. doi:10.1128/JB ... Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infect Immun 74:1673-1682. doi: ... Multiple N-acyl-l-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri. J ...
Zhao, S., Wang, J., Du, X., Wang, J., Cao, R., Yin, Y., Zhang, X., Yuan, Z., Xing, Y., Pui, D. Y. H. & Li, C., May 29 2018, In : ACS Applied Energy Materials. 1, 5, p. 2326-2332 7 p.. Research output: Contribution to journal › Article ...
... some gram-positive bacteria produce γ-butyrolactones as quorum-sensing signals, which are structurally quite similar to AHLs ( ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ... Identification of Quorum-Quenching N-Acyl Homoserine Lactonases from Bacillus Species. Yi-Hu Dong, Andi R. Gusti, Qiong Zhang, ...
Acyl-Butyrolactones Genes The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST). Overbeek, ...
Thermolysis of selenocarbonate 224 in benzene at 80 8C generated the corresponding acyl radical, which underwent cyclization to ... butyrolactones Chemie The amount of research activity concerning a-methylene-g-butyrolactones and a-alkylidene-g-butyrolactones ... Traditional approaches to a-methylene-g-butyrolactones and a-alkylidene-g-butyrolactones are then reviewed together with novel ... Other a-Alkylidene-g-butyrolactones A large number of non-terpenoid, naturally occurring aalkylidene-g-butyrolactones are also ...
Acyl-Butyrolactones/metabolism. *Acyl-Butyrolactones/pharmacology. *Bacterial Adhesion/drug effects. *Candida albicans/drug ... These changes can include alterations in the levels of N-acyl homoserine lactones (HSLs), which are secreted signal molecules. ...
Fingerprint Dive into the research topics where Kazuhiro Toyoda is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
Solo-Gabriele, H. M., Harwood, V. J., Kay, D., Fujioka, R. S., Sadowsky, M. J., Whitman, R. L., Wither, A., Caniça, M., Carvalho da Fonseca, R., Duarte, A., Edge, T. A., Gargaté, M. J., Gunde-Cimerman, N., Hagen, F., McLellan, S. L., Nogueira da Silva, A., Novak Babič, M., Prada, S., Rodrigues, R., Romão, D. & 9 others, Sabino, R., Samson, R. A., Segal, E., Staley, C., Taylor, H. D., Veríssimo, C., Viegas, C., Barroso, H. & Brandão, J. C., Jan 1 2016, In : Journal of the Marine Biological Association of the United Kingdom. 96, 1, p. 101-120 20 p.. Research output: Contribution to journal › Article ...
Wang, H., Tzeng, Y. K., Ji, Y., Li, Y., Li, J., Zheng, X., Yang, A., Liu, Y., Gong, Y., Cai, L., Li, Y., Zhang, X., Chen, W., Liu, B., Lu, H., Melosh, N. A., Shen, Z. X., Chan, K., Tan, T., Chu, S. & 1 others, Cui, Y., Feb 1 2020, In : Nature Nanotechnology. 15, 2, p. 131-137 7 p.. Research output: Contribution to journal › Article ...
Acyl homoserine lactone production of brewery process surface bacteria. Priha, O., Juvonen, R., Tapani, K. & Storgårds, E., ...
The acyl-homoserine lactone synthase YenI from Yersinia enterocolitica modulates virulence gene expression in enterohemorrhagic ...
Kao, Y. C., Rogers, M. W., Bunnell, D. B., Cowx, I. G., Qian, S. S., Anneville, O., Beard, T. D., Brinker, A., Britton, J. R., Chura-Cruz, R., Gownaris, N. J., Jackson, J. R., Kangur, K., Kolding, J., Lukin, A. A., Lynch, A. J., Mercado-Silva, N., Moncayo-Estrada, R., Njaya, F. J., Ostrovsky, I. & 11 others, Rudstam, L. G., Sandström, A. L. E., Sato, Y., Siguayro-Mamani, H., Thorpe, A., van Zwieten, P. A. M., Volta, P., Wang, Y., Weiperth, A., Weyl, O. L. F. & Young, J. D., 1 Dec 2020, In : Nature Communications.. Research output: Contribution to journal › Article ...
Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl ... Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl ... Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl ... Furthermore, the ΔpvdJ and ΔpvdL mutants showed lower abilities to produce tabtoxin, extracellular polysaccharide, and acyl ...
Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ... Activity of MAL was investigated using N-acyl homoserine lactone (AHL) reporters based on the LasR receptor of Pseudomonas ...
Collins, F. L., Schepper, J. D., Rios-Arce, N. D., Steury, M. D., Kang, H. J., Mallin, H., Schoenherr, D., Camfield, G., Chishti, S., McCabe, L. R. & Parameswaran, N., 2017, Understanding the Gut-Bone Signaling Axis: Mechanisms and Therapeutic Implications. McCabe, L. R. & Parameswaran, N. (eds.). Cham: Springer , p. 59-94 36 p. (Advances in Experimental Medicine and Biology; vol. 1033).. Research output: Chapter in Book/Report/Conference proceeding › Chapter ...
Unusual comQXPA-like loci.(A) Non-canonical unusual com system is present in B. cereus VD102, B. cereus BAG4X12 1, B. cereus MSX A1 and L. fusiformis ZC1. Note
Acyl-Butyrolactones [1]. Aerobiosis [1]. AHL [1]. Alphaproteobacteria [2]. Amino Acid Sequence [2]. ...
Acyl-Butyrolactones Medicine & Life Sciences * Enterohemorrhagic Escherichia coli Medicine & Life Sciences * Yersinia ... Nguyen, Y. N., Sheng, H., Dakarapu, R., Falck, J. R., Hovde, C. J., & Sperandio, V. (2013). The acyl-homoserine lactone ... Nguyen, YN, Sheng, H, Dakarapu, R, Falck, JR, Hovde, CJ & Sperandio, V 2013, The acyl-homoserine lactone synthase YenI from ... title = "The acyl-homoserine lactone synthase YenI from Yersinia enterocolitica modulates virulence gene expression in ...
The hydrophobic side chain of the butyrolactones, known generically also as butaneolides, is in the same locus as the N-acyl ... In the case of mycosubtilin, the first five domains of the MycA subunit are dedicated to construction of the C16-β-NH2-acyl ... The N-acylhomoserine lactones of Erwinia, Pseudomonas, and many other bacteria and the γ-butyrolactones of streptomycetes, ... in which all 10 of the ketone groups are thought to persist without reductive modification in the acyl chain. The first cyclase ...
Acyl-Butyrolactones. *Dehydroascorbic Acid. *Macrolides. *Picrotoxin. *Polyketides. *Propiolactone. *Spironolactone. * ...
Acyl-Butyrolactones: 14. *mycolactone A: 13. *phospholine: 13. *ebelactone B: 12. *ginkgolide A: 12 ...
Acyl-Butyrolactones, chemistry, metabolism, Bacterial Proteins, genetics, Biofilms, Gene Expression Regulation, Bacterial, ...
  • in addition to reports describing the isolation of a-methylene- and a-alkylidene-g-butyrolactones, there have been numerous publications covering their biosynthesis, biological properties, and medical applications. (docme.ru)
  • 21. Knochel P.*, Yeh M.C.P., Berk S.C., Talbert J., "Synthesis and Reactivity Toward Acyl chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI" J. Org. (uni-muenchen.de)
  • Acyl-HSLs are synthesized by the LuxI family of synthases, and the signal response is mediated by members of the LuxR family of transcriptional regulators. (elsevier.com)
  • We also show that a strain incapable of acyl-HSL production is capable of growth on the same assortment of carbon and nitrogen sources as the wild type. (elsevier.com)