Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Herpes Simplex: A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)Herpes Genitalis: Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.Herpes Zoster: An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)Herpes Labialis: Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)Herpesvirus 2, Human: A species of SIMPLEXVIRUS associated with genital infections (HERPES GENITALIS). It is transmitted by sexual intercourse and close personal contact.Simplexvirus: A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Encephalitis, Herpes Simplex: An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Herpes Zoster Ophthalmicus: Virus infection of the Gasserian ganglion and its nerve branches characterized by pain and vesicular eruptions with much swelling. Ocular involvement is usually heralded by a vesicle on the tip of the nose. This area is innervated by the nasociliary nerve.Prodrugs: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.GuanineStomatitis, Herpetic: Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.Herpesvirus 3, Human: The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.Keratitis, Dendritic: A form of herpetic keratitis characterized by the formation of small vesicles which break down and coalesce to form recurring dendritic ulcers, characteristically irregular, linear, branching, and ending in knoblike extremities. (Dictionary of Visual Science, 3d ed)Thymidine Kinase: An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.Herpesvirus 1, Human: The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Chickenpox: A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)Virus Shedding: The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).Viral Plaque Assay: Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.Encephalitis, Varicella Zoster: Inflammation of brain tissue caused by infection with the varicella-zoster virus (HERPESVIRUS 3, HUMAN). This condition is associated with immunocompromised states, including the ACQUIRED IMMUNODEFICIENCY SYNDROME. Pathologically, the virus tends to induce a vasculopathy and infect oligodendrocytes and ependymal cells, leading to CEREBRAL INFARCTION, multifocal regions of demyelination, and periventricular necrosis. Manifestations of varicella encephalitis usually occur 5-7 days after onset of HERPES ZOSTER and include HEADACHE; VOMITING; lethargy; focal neurologic deficits; FEVER; and COMA. (From Joynt, Clinical Neurology, 1996, Ch 26, pp29-32; Hum Pathol 1996 Sep;27(9):927-38)Bell Palsy: A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376)Arabinofuranosyluracil: A pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.Skin Diseases, Viral: Skin diseases caused by viruses.Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.Idoxuridine: An analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.Virus Activation: The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.Pharmaceutical Vehicles: A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)Inosine Pranobex: An alkylamino-alcohol complex of inosine used in the treatment of a variety of viral infections. Unlike other antiviral agents, it acts by modifying or stimulating cell-mediated immune processes rather than acting on the virus directly.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Recurrence: The return of a sign, symptom, or disease after a remission.Vidarabine: A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.Keratitis, Herpetic: A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Injections: Introduction of substances into the body using a needle and syringe.Skin Cream: A water-soluble medicinal preparation applied to the skin.Ice Cream: A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.
Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. (1/1121)
The effect of an extensive prophylactic antimicrobial regimen was prospectively assessed in 126 patients after high-dose chemotherapy and autologous PBSC. They received ciprofloxacin (500 mg/12 h), acyclovir (200 mg/6 h), and itraconazole (200 mg/12 h) orally until neutrophil recovery. Febrile patients received i.v. imipenem (500 mg/6 h) to which vancomycin and amikacin were added if fever persisted for 2-3 and 5 days, respectively. Amphotericin B lipid complex was further given on day 7 or 8 of fever. Median times for a neutrophil count of >0.5 x 10(9)/l and a platelet count of >20 x 10(9)/l were 9 and 11 days. Severe neutropenia (<0.1 x 10(9)/l) lasted for a median of 5 days in which 72% of febrile episodes and 50% of cases of bacteremia occurred. Gram-positive bacteria were isolated in 30 of 40 episodes of bacteremia, 25 of which were caused by Staphylococcus epidermidis. Clinical foci were the intravascular catheter in 35 cases, respiratory infection in 11, cellulitis in two, anal abscess in one, and neutropenic enterocolitis in one. The high incidence of febrile episodes (94%) and bacteremias (31%) may be due to the lack of efficacy of antimicrobial prophylaxis and the persistence of a 5-day period of severe neutropenia. (+info)B cell lymphoproliferative disorders following hematopoietic stem cell transplantation: risk factors, treatment and outcome. (2/1121)
Twenty-six cases of B cell lymphoproliferative disorder (BLPD) were identified among 2395 patients following hematopoietic stem cell transplants (HSCT) for which an overall incidence of BLPD was 1.2%. The true incidence was probably higher, since 9/26 of the diagnoses were made at autopsy. No BLPD was observed following autologous HSCT, so risk factor analyses were confined to the 1542 allogeneic HSCT. Factors assessed were HLA-mismatching (> or = 1 antigen), T cell depletion (TCD), presence of acute GvHD (grades II-IV), donor type (related vs unrelated), age of recipient and donor, and underlying disease. Factors found to be statistically significant included patients transplanted for immune deficiency and CML, donor age > or = 18 years, TCD, and HLA-mismatching, with recipients of combined TCD and HLA-mismatched grafts having the highest incidence. Factors found to be statistically significant in a multiple regression analysis were TCD, donor age and immune deficiency, although 7/8 of the patients with immunodeficiencies and BLPD received a TCD graft from a haploidentical parent. The overall mortality was 92% (24/26). One patient had a spontaneous remission, but subsequently died >1 year later of chronic GVHD. Thirteen patients received therapy for BLPD. Three patients received lymphocyte infusions without response. The only patients with responses and longterm survival received alpha interferon (alphaIFN). Of seven patients treated with alphaIFN there were four responses (one partial and three complete). These data demonstrate that alphaIFN can be an effective agent against BLPD following HSCT, if a timely diagnosis is made. (+info)Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. (3/1121)
The results of previous work performed in our laboratory using an in situ perfusion technique in rats and rabbit apical brush border membrane vesicles have suggested that the intestinal uptake of valacyclovir (VACV) appears to be mediated by multiple membrane transporters. Using these techniques, it is difficult to characterize the transport kinetics of VACV with each individual transporter in the presence of multiple known or unknown transporters. The purpose of this study was to characterize the interaction of VACV and the human intestinal peptide transporter using Chinese hamster ovary (CHO) cells that overexpress the human intestinal peptide transporter (hPEPT1) gene. VACV uptake was significantly greater in CHO cells transfected with hPEPT1 than in cells transfected with only the vector, pcDNA3. The optimum pH for VACV uptake was determined to occur at pH 7.5. Proton cotransport was not observed in hPEPT1/CHO cells, consistent with previously observed results in tissues and Caco-2 cells. VACV uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64 +/- 0.06 mM and 23.34 +/- 0.36 nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, suggesting that hPEPT1 dominates the intestinal transport properties of VACV in vitro. VACV uptake was markedly inhibited by various dipeptides and beta-lactam antibiotics, and Ki values of 12.8 +/- 2.7 and 9.1 +/- 1.2 mM were obtained for Gly-Sar and cefadroxil at pH 7.5, respectively. The present results demonstrate that VACV is a substrate for the human intestinal peptide transporter in hPEPT1/CHO cells and that although transport is pH dependent, proton cotransport is not apparent. Also, the results demonstrate that the hPEPT1/CHO cell system has use in investigating the transport kinetics of drugs with the human intestinal peptide transporter hPEPT1; however, the extrapolation of these transport properties to the in vivo situation requires further investigation. (+info)Management of human cytomegalovirus infection and disease after allogeneic bone marrow transplantation. (4/1121)
BACKGROUND AND OBJECTIVE: Human cytomegalovirus (HCMV) infection and disease remain a major cause of morbidity and mortality after bone marrow transplantation. HCMV disease, especially pneumonitis, may be treated with ganciclovir and immunoglobulin but even so the outcome is poor with mortality rates of 30-70%. It is therefore imperative to treat HCMV infection before it develops into disease. The aim of this article is to describe the main strategies used to prevent HCMV infection and to improve the survival after CMV disease in bone marrow transplant recipients. INFORMATION SOURCES: In the present review, we examined personal papers in this field and articles published in journals covered by the Science Citation Index and Medline. STATE OF THE ART: Major advances have been made in preventing HCMV infection and disease through two different approaches, both of which reduce HCMV induced morbidity and mortality: In pre-emptive therapy, patients are given ganciclovir when HCMV infection is first identified and this is continued 3-4 months after transplantation; in prophylactic therapy ganciclovir is given to all patients at risk of HCMV disease from engraftment up to 3-4 months post transplantation. Each strategy has advantages and disadvantages and there is no evidence for the superiority of one over the other since the overall survival is the same and the incidence of death from HCMV disease is similar. PERSPECTIVES: The use of more sensitive tests such as HCMV PCR or antigenemia may improve the outcome but probably will not eradicate all HCMV disease. Future possible strategies could include adoptive transfer of CD8+ HCMV-specific cytotoxic T lymphocytes clones derived from the donor marrow or boosting donor or patient immunity using subunit anti-HCMV vaccines such as gB or pp65. (+info)Antiviral therapy for neonatal herpes simplex virus: a cost-effectiveness analysis. (5/1121)
Each year, about 1,600 infants in the United States are infected with neonatal herpes simplex virus. We conducted a cost-effectiveness analysis of antiviral drug therapy (acyclovir) for three forms of herpes simplex virus infection: skin, ear, and mouth (SEM), central nervous system (CNS), and disseminated multiorgan (DIS) disease. Five levels of patient outcomes were examined (normal, mild, moderate, severe, dead). We obtained information on disease occurrence and survival from clinical trials and historical reviews of untreated newborns. We considered approaches for treating all or any of the forms of the disease and compared them with no use of antiviral drugs. The main measure of effectiveness was lives saved, including those of descendants of survivors. Costs were measured from a societal perspective and included direct medical costs, institutional care, and special education. We used a discount rate of 3% and valued dollars at 1995 levels. We also considered the perspective of a managed care organization. From a societal viewpoint relative to no treatment, antiviral therapy for SEM resulted in a gain of 0.8 lives and a cost reduction of $78,601 per case. For the treatment of CNS and DIS disease, antiviral therapy saved more lives but at increased cost, with respective marginal costs per additional life saved of $75,125 and $46,619. From a managed care perspective, antiviral therapy is more cost-effective than from a societal viewpoint because costs of institutional care and special education are not the responsibility of managed care organizations. Development of at-home therapies will further improve the cost-effectiveness of antiviral therapy for neonatal herpes simplex virus infection. (+info)Intravenous penciclovir for treatment of herpes simplex infections in immunocompromised patients: results of a multicenter, acyclovir-controlled trial. The Penciclovir Immunocompromised Study Group. (6/1121)
The efficacy and safety of penciclovir (PCV) for the treatment of herpes simplex virus (HSV) infections in immunocompromised (IC) patients were studied in a double-blind, acyclovir (ACV)-controlled, multicenter study. A total of 342 patients with mucocutaneous HSV infections received 5 mg of PCV per kg every 12 or 8 h (q12h or q8h) or 5 mg of ACV per kg q8h, beginning within 72 h of lesion onset and continuing for up to 7 days. The mean age of the patients was 49 years; 94% were white and 52% were female. The main reasons for their IC states were hematologic disorder (63%) and transplant plus hematologic disorder (16%). Clinical and virological assessments were performed daily during the 7-day treatment and then every other day until lesion healing. The primary efficacy parameter addressed new lesion formation. Secondary end points focused on viral shedding, healing, and pain. Approximately 20% of patients in each treatment group developed new lesions during therapy; thus, equivalence with ACV (defined prospectively) was demonstrated for both q12h and q8h PCV regimens. For all three treatment groups, the median time to the cessation of viral shedding was 4 days and the median time to complete healing was 8 days; there were no statistically significant differences in the rates of complete healing or the cessation of viral shedding when the results for PCV q12h and q8h were compared with those for ACV q8h. In addition, there was no statistically significant difference between PCV q12h or q8h, compared with ACV q8h, for the resolution of pain. PCV was well tolerated, with an adverse event profile comparable to that of ACV. In conclusion, PCV q12h is a well-tolerated and effective therapy for mucocutaneous HSV infection in IC patients and offers a reduced frequency of dosing compared with ACV q8h. (+info)Valacyclovir for the prevention of cytomegalovirus disease after renal transplantation. International Valacyclovir Cytomegalovirus Prophylaxis Transplantation Study Group. (7/1121)
BACKGROUND: Cytomegalovirus (CMV) disease is a major complication of organ transplantation. We hypothesized that prophylactic treatment with valacyclovir would reduce the risk of CMV disease. METHODS: A total of 208 CMV-negative recipients of a kidney from a seropositive donor and 408 CMV-positive recipients were randomly assigned to receive either 2 g of valacyclovir or placebo orally four times daily for 90 days after transplantation, with the dose adjusted according to renal function. The primary end point was laboratory-confirmed CMV disease in the first six months after transplantation. RESULTS: Treatment with valacyclovir reduced the incidence or delayed the onset of CMV disease in both the seronegative patients (P<0.001) and the seropositive patients (P=0.03). Among the seronegative patients, the incidence of CMV disease 90 days after transplantation was 45 percent among placebo recipients and 3 percent among valacyclovir recipients. Among the seropositive patients, the respective values were 6 percent and 0 percent. At six months, the incidence of CMV disease was 45 percent among seronegative recipients of placebo and 16 percent among seronegative recipients of valacyclovir; it was 6 percent among seropositive placebo recipients and 1 percent among seropositive valacyclovir recipients. At six months, the rate of biopsy-confirmed acute graft rejection in the seronegative group was 52 percent among placebo recipients and 26 percent among valacyclovir recipients (P=0.001). Treatment with valacyclovir also decreased the rates of CMV viremia and viruria, herpes simplex virus disease, and the use of inpatient medical resources. Hallucinations and confusion were more common with valacyclovir treatment, but these events were not severe or treatment-limiting. The rates of other adverse events were similar among the groups. CONCLUSIONS: Prophylactic treatment with valacyclovir is a safe and effective way to prevent CMV disease after renal transplantation. (+info)Long term neurological outcome of herpes encephalitis. (8/1121)
Twenty eight children with herpes simplex encephalitis were followed up for a mean of 5.5 years. Two children died and 26 survived, of whom 16 were left with no neurological sequelae and 10 had persistent neurological sequelae. Mean (SD) Glasgow coma score was significantly lower in the patients with neurological sequelae (7.7 (1.5)) and the patients who died (4.5 (0.7)), compared with the patients without neurological sequelae (11 (1.7)). (+info)9. ACYCLOVIR 10. ADENOSINE 11. ADRENOCORTICOTROPHIC HORMONE (ACTH) 12. ALENDRONATE SODIUM 13. ALLOPURINOL ...
Such drugs include other aminoglycosides; the antiviral acyclovir; the antifungal amphotericin B; the antibiotics bacitracin, ...
Aciclovir. Antiretrovirals[edit]. Nucleoside/nucleotide reverse transcriptase inhibitors[edit]. *Abacavir (ABC). *Lamivudine ( ...
aciclovir trials in the late 1980s.[106] The lower toxicity and ease of administration over vidarabine has led to aciclovir ... Several antiviral drugs are effective for treating herpes, including aciclovir (acyclovir), valaciclovir, famciclovir, and ... aciclovir seems to inhibit antibody response, and newborns on aciclovir antiviral treatment experienced a slower rise in ... Aciclovir was the first discovered and is now available in generic.[61] Valaciclovir is also available as a generic[62] and is ...
Related antiviral drugs Aciclovir Valacyclovir, a prodrug form of aciclovir Famciclovir, an analogue of Penciclovir with ... It is taken orally once daily, in contrast to aciclovir, valaciclovir and other antivirals. A study has found that it is more ... 5246-8. ISBN 978-3-85200-181-4. "Brivudin (Zostex) besser als Aciclovir (Zovirax a.a.)?". Arznei-telegramm (in German). 5/2007 ... effective than aciclovir, but this has been disputed because of a possible conflict of interest on part of the study authors. ...
Acyclovir, steroids and therapeutic plasma exchange have been tried; one report suggests that the latter is more effective than ...
Systemic aciclovir facilitates the early control of HZO lesions. James, William D.; Berger, Timothy G.; et al. (2006). Andrews ... Treatment is usually with antivirals such as aciclovir orally. Topical steroids and cycloplegics for several months. ...
One review found that antivirals (such as aciclovir) are ineffective in improving recovery from Bell's palsy beyond steroids ... prednisone and acyclovir). Other research, however, identifies HSV-1 in only 31 cases (18 percent), herpes zoster (zoster sine ... "Early treatment with prednisolone or acyclovir in Bell's palsy". New England Journal of Medicine. 357 (16): 1598-607. doi ...
For herpes the treatment of choice is aciclovir.[23]. Surgical management is indicated where there is extremely increased ...
"Acyclovir". The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015. ... The antiviral drug acyclovir, often used in herpes treatment, and the anti-HIV drug abacavir, are structurally similar to ...
... is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir ... Aciclovir is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times ... Aciclovir, the active metabolite of valaciclovir, is active against most species in the herpesvirus family. In descending order ... Common adverse drug reactions (≥1% of people) associated with valaciclovir are the same as for aciclovir, its active metabolite ...
S01AD03 Aciclovir. S01AD05 Interferon. S01AD06 Vidarabine. S01AD07 Famciclovir. S01AD08 Fomivirsen. S01AD09 Ganciclovir. S01AX ...
... acyclovir,[33] simvastatin,[34][35] xibornol,[36] silymarin,[37][38] alpha-asarone,[39] enilconazole,[19] puerarin (an ... Patel D; Sawant KK (December 2007). "Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery ...
... acyclovir, which was the first selective and effective drug of its kind).[25] Most of Elion's early work came from the use and ... acyclovir (ACV), used in the treatment of herpes infection.[3] ... Acyclovir (Zovirax), for viral herpes.[19]. *Nelarabine for ... "Developing the Purine Nucleoside Analogue Acyclovir: the Work of Gertrude B. Elion". J. Biol. Chem. 283 (19): e11. Retrieved ...
Multimedia: Aciclovir. *Identifikadoreak. *LCCN: sh88002652. *Hiztegiak eta entziklopediak. *Britannica: url. *Medikuntzako ...
acyclovir trials in the late 1980s.[101] The lower toxicity and ease of administration over vidarabine has led to acyclovir ... acyclovir seems to inhibit antibody response, and newborns on acyclovir antiviral treatment experienced a slower rise in ... Acyclovir was the first discovered and is now available in generic.[56] Valacyclovir is also available as a generic[57] and is ... "Acyclovir for treating primary herpetic gingivostomatitis". Cochrane Database Syst Rev (4): CD006700. doi:10.1002/14651858. ...
Intravenous aciclovir, can be used to prevent viral replication, and in the event of persistent lymphocytic pleocytosis, higher ... Since herpes infections often lead to pleocytosis, aciclovir and valacyclovir are commonly prescribed. When pleocytosis is the ... doses of aciclovir can also be taken. Studies have shown this treatment combined with valacyclovir to be effective in combating ...
acyclovir (Zovirax), for viral herpes. 1996 Stanley Norman Cohen (Co-recipient, Lemelson-MIT Prize) for the development of ...
Aciclovir is one of the oldest and most frequently prescribed antiviral drugs.[205] Other antiviral drugs in use target ... This is called DNA chain termination.[204] Examples of nucleoside analogues are aciclovir for Herpes simplex virus infections ... Mindel A, Sutherland S. Genital herpes - the disease and its treatment including intravenous acyclovir. Journal of ... The structure of the DNA base guanosine and the antiviral drug acyclovir ...
acyclovir trials in the late 1980s. The lower toxicity and ease of administration over vidarabine has led to acyclovir becoming ... However, acyclovir seems to inhibit antibody response, and newborns on acyclovir antiviral treatment experienced a slower rise ... Acyclovir was the first discovered and is now available in generic. Valacyclovir is also available as a generic and is slightly ... Acyclovir is the recommended antiviral for herpes suppressive therapy during the last months of pregnancy. The use of ...
Antiviral drugs such as acyclovir have been tried during the terminal phase of the disease. Cyclophosphamide and prednisone ...
Trifluridine Acyclovir Foscarnet Prusoff, W. H. (1959). "Synthesis and biological activities of iododeoxyuridine, an analog of ...
... has also shown efficacy in the treatment of aciclovir-resistant HSV infections. Cidofovir has also been investigated ... Chilukuri, S; Rosen, T (Apr 2003). "Management of acyclovir-resistant herpes simplex virus". Dermatologic clinics. 21 (2): 311- ... likely due to the abundance of safer alternatives such as aciclovir. Cidofovir shows anti-BK virus activity in a subgroup of ... aciclovir, aminosalicylic acid, etc.) are also withheld. Its active metabolite, cidofovir diphosphate, inhibits viral ...
Elion GB (1993). "Acyclovir: discovery, mechanism of action, and selectivity". J. Med. Virol. Suppl 1: 2-6. PMID 8245887. ... acyclovir for herpes virus infection, and nelarabine for cancer treatment. Since 2010, GlaxoSmithKline has several times ranked ...
December 1988). "Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial". N. Engl ... A small 1988 RCT compared acyclovir against placebo and found that an equal proportion of patients improved from placebo and ... Nucleosidic class drugs such as acyclovir, valacyclovir and ganciclovir are inhibitors of viral replication during DNA (for DNA ... Three people withdrew from acyclovir treatment due to reversible renal failure. Antidepressants are often prescribed to CFS ...
The drug of choice is acyclovir.[4] Classification. Herpes simplex encephalitis may be classified according to origin of ... The drug of choice is acyclovir.[4] Supportive therapy for herpes simplex encephalitis includes breathing assistance, ...
Aciclovir. Famciclovir. Other. Comprehensive Review of Market Growth, Future Prospects, and Applications: ...
Valacyclovir, a prodrug of acyclovir, produces serum acyclovir levels that are three to five times as high as those achieved ... Oral acyclovir in the treatment of herpes zoster in general practice. N Z Med J 1989;102:93-95. [ISI][Medline] ... Acyclovir, valacyclovir, and famciclovir are approved for the treatment of herpes zoster. These drugs are well tolerated and ... Wood MJ, Johnson RW, McKendrick MW, Taylor J, Mandal BK, Crooks J. A randomized trial of acyclovir for 7 days and 21 days with ...
There was low quality evidence from 1 RCT that long-term use of oral aciclovir reduced clinical recurrences (1.80 versus 0.85 ... One RCT found significantly fewer research-diagnosed recurrences of HSL when on aciclovir cream treatment than on placebo (P , ... There was moderate quality evidence from 2 RCTs that topical aciclovir 5% cream probably has little effect on preventing ... use of oral aciclovir in preventing recurrent HSL was inconsistent across the doses used in the studies: 2 RCTs showed low ...
All patients were treated with intravenous acyclovir 10 mg/kg 3 times daily or oral valacyclovir 3 g/day for 7 to 10 days. ... A good recovery of HZO optic neuritis with systemic acyclovir and steroid has been also reported [18]. ...
The systemic component of this disorder is best treated with oral acyclovir, (Zovirax), 600 to 800mg five times a day for seven ... has been shown to be as effective in treating herpes zoster ophthalmicus as acyclovir 800mg fives times per day. Timing is ...
Acyclovir: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Take or use acyclovir until you finish the prescription, even if you feel better. If you stop taking acyclovir too soon or skip ... Before taking acyclovir,. *tell your doctor and pharmacist if you are allergic to acyclovir, valacyclovir (Valtrex), any other ... If you become pregnant while taking acyclovir, call your doctor.. *if you are taking acyclovir to treat genital herpes, you ...
Acyclovir Topical: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Acyclovir cream is usually applied five times a day for 4 days. Acyclovir cream may be applied at any time during a cold sore ... Acyclovir cream and ointment are for use only on the skin. Do not let acyclovir cream or ointment get into your eyes, or inside ... Acyclovir cream should only be applied to skin where a cold sore has formed or seems likely to form. Do not apply acyclovir ...
Congenital Abnormality Transmit Disease Advisory Committee Acyclovir Disease Treatment These keywords were added by machine and ...
Acyclovir definition, a crystalline compound, C18H11N5O3, used as an antiviral drug in the treatment of herpes infections. See ... acyclovir. 1980-85; perhaps acyclo(guanosine) an earlier name for the compound (a-6 + cyclo- + guanosine a nucleotide) + vir(us ...
The acyclovir oral tablet is used to treat viral infections such as shingles, genital herpes, and chickenpox. This form is ... Acyclovir comes in several prescription forms, including an oral tablet. ... Highlights for acyclovir. *Acyclovir oral tablet is available as both a generic and a brand-name drug. Brand name: Zovirax. ... How to take acyclovir. This dosage information is for acyclovir oral tablet. All possible dosages and drug forms may not be ...
... acyclovir, herpes - Answer: The first outbreak is usually the worst. It will take a few days before it ... ... How fast should Acyclovir.... How fast should Acyclovir work?. Asked. 1 Aug 2014 by helpp_30. Updated. 24 November 2018 (8 ... pain, acyclovir, herpes. Details:. I was told that I have herpes yesterday, but I feel like I waited too long to go to the dr, ... Acyclovir - So I got diagnosed with genital herpes I am to take 5 pills a day but Im confused?. Updated 3 Oct 2017 • 2 answers ...
Aciclovir-induced acute kidney injury. Medicina Clinica 154: 36, No. 1, 10 Jan 2020. Available from: URL: http://doi.org/ ... Aciclovir. Reactions Weekly 1790, 12 (2020). https://doi.org/10.1007/s40278-020-74631-y ...
Do not use Acyclovir Cream if you are:. •. allergic to Acyclovir Cream or any of the ingredients in Acyclovir Cream. See the ... Each gram of Acyclovir Cream 5% contains 50 mg acyclovir in an aqueous cream base. Acyclovir Cream is supplied as follows:. •. ... The pKas of acyclovir are 2.27 and 9.25.. Each gram of Acyclovir Cream 5% contains 50 mg of acyclovir and the following ... Systemic absorption of acyclovir from Acyclovir Cream is minimal in adults.. The systemic absorption of acyclovir following ...
Acyclovir capsule is a formulation for oral administration. Each capsule of acyclovir contains 200 mg of acyclovir and the ... Acyclovir pharmacokinetic parameters are summarized in Table 1.. Table 1. Acyclovir Pharmacokinetic Characteristics (Range) ... Acyclovir was positive in 5 of the assays.. Acyclovir did not impair fertility or reproduction in mice (450 mg/kg/day, p.o.) or ... The pkas of acyclovir are 2.27 and 9.25.. The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H ...
Renal function after acyclovir intravenous injection.. Brigden D, Rosling AE, Woods NC. ... Plasma urea or creatinine was noted to be raised in 58 of 354 patients treated with intravenous acyclovir. This occurred after ... Animal studies indicate that the impairment of renal function associated with high bolus injections of acyclovir is due to ... intravenous bolus injection of high dosages of acyclovir but the risk was considerably reduced by slow intravenous infusion of ...
Acyclovir Suspension). Includes indications, proper use, special instructions, precautions, and possible side effects. ... Cold Sores acyclovir, Valtrex, valacyclovir, famciclovir, tetracaine topical, More.... Herpes Simplex acyclovir, Abreva, ... Herpes Simplex - Congenital acyclovir, More.... Herpes Simplex, Suppression acyclovir, Valtrex, valacyclovir, lysine, ... If you are taking Zovirax (acyclovir suspension) for an infection that came back, start Zovirax (acyclovir suspension) as soon ...
Acyclovir will not cure herpes, but it can lessen the symptoms of the infection. Acyclovir is used to treat infections caused ... Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus in the body. ... What is acyclovir?. Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus in the body. Acyclovir ... What other drugs will affect acyclovir?. Acyclovir can harm your kidneys. This effect is increased when you also use certain ...
Acyclovir for uncomplicated chickenpox?. BMJ 1993; 306 doi: https://doi.org/10.1136/bmj.306.6890.1478-c (Published 29 May 1993) ...
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Find treatment reviews for Acyclovir from other patients. Learn from their experiences about effectiveness, side effects and ... Showing 3 of 15 patient evaluations for Acyclovir Previous page 1 2 3 4 5 Next page ...
... Learn about the reported side effects, related class drugs, and ... ACYCLOVIR (ay SYE kloe veer) is an antiviral medicine. It is used to treat or prevent infections caused by certain kinds of ...
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Virasorb cold sore cream contains the active ingredient aciclovir, which is an antiviral medicine used to treat infections with ... Virasorb cold sore cream (aciclovir). Virasorb cold sore cream contains the active ingredient aciclovir, which is an antiviral ... Aciclovir is converted to a more active form inside cells of the body that are infected with herpes simplex. The activated ... This aciclovir cream is designed for the treatment of herpes simplex infections of the lips (cold sores). The cream should be ...
Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex ... In those with herpes of the eye, aciclovir may be more effective and safer than idoxuridine. It is not clear if aciclovir eye ... aciclovir may be used. For severe HSV infections (especially disseminated HSV), IV aciclovir may also be used. Studies in mice ... Aciclovir trials show that this agent has no role in preventing HIV transmission, but it can help slow HIV disease progression ...
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- There was low quality evidence from 1 RCT that long-term use of oral aciclovir reduced clinical recurrences (1.80 versus 0.85 episodes per participant per a 4-month period, P = 0.009) and virological recurrence (1.40 versus 0.40 episodes per participant per a 4-month period, P = 0.003). (altmetric.com)
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- Dear Doctor, I did a HIV Test + p24 antigen at 100 days and was negative but in that period I was taking Aciclovir 400mg. (thebody.com)
- This occurred after intravenous bolus injection of high dosages of acyclovir but the risk was considerably reduced by slow intravenous infusion of the same dosage over one hour, with adequate hydration of the patient and adjustment of dosage in patients with preexisting impaired renal function. (nih.gov)
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- However, if it is almost time for the acyclovir dosage ointment next dose, skip the ointment missed dose and continue your regular dosing schedule. (sportsrubbish.com)
- tell your doctor and pharmacist if you are allergic to acyclovir, valacyclovir (Valtrex), any other medications, milk proteins, or any of the ingredients in acyclovir products. (medlineplus.gov)
- Acyclovir Cream is contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir or any component of the formulation. (nih.gov)
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- A study showed that antiviral drugs, such as acyclovir, valacyclovir and famcyclovir, helped to clear a herpes zoster (shingles) outbreak, but had no effect on the lingering pain caused by the virus (1). (prweb.com)
- Do not let acyclovir cream or ointment get into your eyes, or inside your mouth or nose, and do not swallow the medication. (medlineplus.gov)
- Acyclovir and hydrocortisone topical may also be used for purposes not listed in this medication guide. (rexhealth.com)
- Aciclovir (ACV), also known as acyclovir, is an antiviral medication. (wikipedia.org)
- Studies also indicate that taking Acyclovir for shingles, along with another type of medication, could even be more effective. (wisegeek.com)
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- Though Acyclovir is generally a prescription medication, they are widely distributed all over the Internet for the millions of cold sore and fever blister sufferers all over the world. (coldsoreproof.com)
- You most likely have heard of the medication Acyclovir for cold sores. (coldsoreproof.com)
- As you know, the herpes simplex is the causative virus that causes cold sore outbreaks and the anti-viral property in Acyclovir medication makes it effective in fighting against it. (coldsoreproof.com)
- Many people can attest to the effectiveness of Acyclovir prescription medication to treat their cold sore outbreak faster. (coldsoreproof.com)
- In part B, fewer acyclovir recipients formed new lesions during the study medication period than did placebo recipients. (nih.gov)
- However, you should not flush this acyclovir cream medication down the toilet. (sportsrubbish.com)
- These factors may affect how acyclovir you should use this medication. (sportsrubbish.com)
- If you stop taking acyclovir too soon or skip doses, your infection may not be completely treated or may become more difficult to treat. (medlineplus.gov)
- If acyclovir it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. (sportsrubbish.com)
- Plasma urea or creatinine was noted to be raised in 58 of 354 patients treated with intravenous acyclovir. (nih.gov)
- This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. (nih.gov)
- In vitro, acyclovir triphosphate stops replication of herpes viral DNA. (nih.gov)
- The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral TK. (nih.gov)
- Resistance of HSV and VZV to acyclovir can result from qualitative and quantitative changes in the viral TK and/or DNA polymerase. (nih.gov)
- While most of the acyclovir-resistant mutants isolated thus far from immunocompromised patients have been found to be TK-deficient mutants, other mutants involving the viral TK gene (TK partial and TK altered) and DNA polymerase have been isolated. (nih.gov)
- The possibility of viral resistance to acyclovir should be considered in patients who show poor clinical response during therapy. (nih.gov)
- The activated aciclovir works by blocking the action of a viral enzyme called DNA polymerase. (netdoctor.co.uk)
- After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization. (cancer.gov)
- Acyclovir will not treat a viral infection such as the common cold or flu. (adventisthealthcare.com)
- To achieve maximal benefit from antiviral therapy, acyclovir must be initiated before widespread viral dissemination throughout the body or to significant replication within the central nervous system (CNS). (aappublications.org)
- Although clinically significant viral resistance associated with the use of acyclovir ointment 5 has not been observed, this possibility exists. (sportsrubbish.com)
- As prednisone has a limited role in improving the recovery of incomplete Bell's palsy and medical literature postulates a viral etiology in Bell's palsy, you wonder whether acyclovir would improve the outcome for this patient. (bestbets.org)
- Acyclovir comes as a tablet, a capsule, and a suspension (liquid) to take by mouth. (medlineplus.gov)
- Acyclovir is also available as a capsule, suspension, and buccal tablet you take by mouth. (medicalnewstoday.com)
- 1 tablet indeholder 200 mg aciclovir. (medicin.dk)
- Usual Adult Dose for Herpes Simplex Labialis Immunocompetent host: Apply 50 mg (1 buccal tablet) as a single-dose to the upper gum region (canine fossa) Comments: -Tablet should be applied acyclovir within 1 hour after the onset of day prodromal symptoms. (silentbobspeaks.com)
- For the Herpes Simplex Virus (HPV) take Aciclovir for at least 5 days, taking a 200mg at least 5 times a day. (chemistdirect.co.uk)
- FDA pregnancy category B. Acyclovir and hydrocortisone topical is not expected to harm an unborn baby. (rexhealth.com)
- Some physicians have reported intentional use of acyclovir during pregnancy for treatment of life-threatening herpes simplex infection. (cdc.gov)
- To assess the outcomes of pregnancies exposed to acyclovir, the Acyclovir in Pregnancy Registry was established on June 1, 1984, by the manufacturer, in collaboration with CDC. (cdc.gov)
- Editorial Note: Based on comparisons with birth defects surveillance data maintained by CDC, the registry findings summarized in this report indicate no increased risk for birth defects among infants born to women exposed to acyclovir during pregnancy (3). (cdc.gov)
- Aciclovir is recommended by the CDC for treatment of varicella during pregnancy, especially during the second and third trimesters Aciclovir is excreted in the breast milk, therefore it is recommended that caution should be used in breast-feeding women. (wikipedia.org)
- Less than when to take acyclovir during pregnancy at short, k leukotriene receptor blockers. (imagenenaccion.org)
- Pyrimethamine is symptomatically useful for evidence that patients with nicotinic-receptor-antagonist when to take acyclovir during pregnancy properties. (imagenenaccion.org)
- Acyclovir in pregnancy registry: six years' experience. (rti.org)
- The Acyclovir in Pregnancy Registry was established to gather data on prenatal exposure to acyclovir. (rti.org)
- Topical acyclovir comes as a cream and an ointment to apply to the skin. (medlineplus.gov)
- Use topical acyclovir exactly as directed. (medlineplus.gov)
- Although topical acyclovir will not cure herpes simplex, it may help relieve the pain and discomfort and may help the sores (if any) heal faster. (mayoclinic.org)
- Topical acyclovir may also be used for other conditions as determined by your doctor. (mayoclinic.org)
- Treatment of erythema multiforme secondary to herpes simplex by prophylactic topical acyclovir. (bmj.com)
- Kennedy C T , Leigh I M , Ridgway H A , Wansbrough-Jones M H , Brigden D . Treatment of erythema multiforme secondary to herpes simplex by prophylactic topical acyclovir. (bmj.com)
- It is not likely that other drugs you take orally or inject will have an effect on topically applied acyclovir. (everydayhealth.com)
- Orally administered acyclovir in children less than 2 years of age has not yet been fully studied. (rxmed.com)
- Some people use Acyclovir in the form of an ointment, and with this form of the drug, dizziness is less likely to be a problem, so drinking alcohol will have less of an effect than if the drug is taken orally. (accessrx.com)
- Episodic (Intermittent) Therapy: Effective treatment requires therapy initiation acyclovir 400 mg within 1 day acyclovir of lesion onset or during the prodrome preceding an episode/recurrence 400 mg orally 3 times a day for 5 to 14 days. (silentbobspeaks.com)
- Acyclovir belongs to a class of drugs called antivirals. (medicalnewstoday.com)
- Clinical experience has identified no interactions resulting from topical or systemic administration of other drugs concomitantly with Acyclovir Cream. (nih.gov)
- Aglaia Koutsodimou and Giovanni Natile, "Reaction of cis - and trans -Dichlorotetra(Dimethylsulfoxide)Ruthenium(II) With the Antiviral Drug Acyclovir," Metal-Based Drugs , vol. 7, no. 6, pp. 325-334, 2000. (hindawi.com)
- NC NOT covered Drugs that acyclovir acyclovir are not covered by the plan. (sportsrubbish.com)
- Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let acyclovir your prescriber know if you use them. (sportsrubbish.com)
- The risks of Acyclovir include nausea and vomiting, diarrhea and headaches among others. (wisegeek.com)
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- People who take Acyclovir report side effects including nausea, dizziness, and drowsiness. (accessrx.com)
- Los fármacos aprobados en Europa para el tratamiento sistémico del herpes zóster son aciclovir, valaciclovir. (cysers.info)
- Valaciclovir er i sammenligning med aciclovir vist at have signifikant hurtigere smertelindrindende effekt på zosterrelaterede smerter og at være associeret med signifikant lavere forekomst af postherpetisk neuralgi. (medicin.dk)
- Each gram of Acyclovir Cream 5% contains 50 mg of acyclovir. (nih.gov)
- Each gram of acyclovir ointment USP 5% contains 50 mg of acyclovir USP in a polyethylene glycol (PEG) base. (bioportfolio.com)
- Acyclovir for uncomplicated chickenpox? (bmj.com)
- The prophylactic use of acyclovir in chickenpox has not been established. (rxmed.com)
- Methods: We plan an individually randomized double blind placebo-control trial of the WHO and US CDC recommended dose of 3-times daily acyclovir for a 5-day treatment course. (clinicaltrials.gov)
- In 1 of these studies, which included 16 inpatients, the complete ointment or its vehicle were randomly administered in a dose of 1-cm strips (25 mg acyclovir) 4 times a day for 7 days to an intact skin surface area of 4.5 square inches. (bioportfolio.com)
- Coombs RW, Collier AC, Chaloupka K, Corey L. Decreased HIV plasma titer in response to combined low-dose zidovudine and acyclovir therapy in CDC class IVA patients. (clinicaltrials.gov)
- On hospital day 8, intravenous acyclovir therapy was initiated at a dose of 250 mg/m 2 body surface area every 8 hours. (annals.org)
- Idiopathic Facial Paralysis: A randomized, prospective and controlled study using single-dose prednisone versus acyclovir three times daily. (bestbets.org)
- The active ingredient is acyclovir. (chemistdirect.co.uk)
- It is a kind of antiviral medicine which contains the active ingredient aciclovir. (dokteronline.com)
- Most makes of aciclovir cream come in a tube and contain 5% of the active ingredient aciclovir. (dokteronline.com)
- What is the most important information I should know about acyclovir and hydrocortisone topical? (rexhealth.com)
- Acyclovir and hydrocortisone topical is for use for cold sores on the lips and around the mouth. (rexhealth.com)
- The combination of acyclovir and hydrocortisone topical (for the skin) is used to treat cold sores in people who are at least 12 years old. (rexhealth.com)
- What should I discuss with my healthcare provider before using acyclovir and hydrocortisone topical? (rexhealth.com)
- To make sure you can safely use acyclovir and hydrocortisone topical, tell your doctor if you have a weak immune system (caused by disease by or using certain medicines). (rexhealth.com)
- It is not known whether acyclovir and hydrocortisone topical passes into breast milk or if it could harm a nursing baby. (rexhealth.com)
- Acyclovir and hydrocortisone topical should not be used on a child younger than 12 years old. (rexhealth.com)
- How should I use acyclovir and hydrocortisone topical? (rexhealth.com)
- Treatment with acyclovir and hydrocortisone topical should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters). (rexhealth.com)
- Apply a thin layer of acyclovir and hydrocortisone topical cream to cover the cold sore or tingly area. (rexhealth.com)
- Acyclovir and hydrocortisone topical cream may be applied 5 times daily for 5 days. (rexhealth.com)
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- Take or use acyclovir until you finish the prescription, even if you feel better. (medlineplus.gov)
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- Other side effects of Acyclovir that should be reported to a physician right away include extreme fatigue, changes in heart rate, easy bruising or bleeding, dark or bloody urine, severe gastric pain, vision changes, seizures, or yellowing of the skin or the whites of the eyes. (accessrx.com)
- The most common problem that can occur when a person taking Acyclovir drinks alcohol is an amplification of the dizziness and drowsiness that frequently occur as side effects of the drug. (accessrx.com)
- People who drink while taking Acyclovir are more likely to experience side effects such as fainting or changes in vision. (accessrx.com)
- Please note, like all medicine, Aciclovir tablets can cause side effects although this does not apply to everyone who has taken them. (chemistdirect.co.uk)
- Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and acyclovir triphosphate. (rxmed.com)
- Acyclovir triphosphate is both an inhibitor of, and a substrate for, herpesvirus-specified DNA polymerase. (rxmed.com)
- Although the cellular a-DNA polymerase in infected cells may also be inhibited by acyclovir triphosphate, this occurs only at concentrations of acyclovir triphosphate which are higher than those which inhibit the herpesvirus-specified DNA polymerase. (rxmed.com)
- Acyclovir Cream is a herpes simplex virus (HSV) nucleoside analogue DNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older. (nih.gov)
- By blocking the action of DNA polymerase, aciclovir prevents the herpes virus from multiplying. (netdoctor.co.uk)
- Aciclovir virker selektivt i herpesinficerede celler, da stoffet fosforyleres af den herpesvirusspecifikke thymidinkinase til aciclovirmonofosfat, der hæmmer den herpesvirusspecifikke DNA-polymerase, hvorved virusproduktionen ophører. (medicin.dk)
- Renal function after acyclovir intravenous injection. (nih.gov)
- How should I use acyclovir injection? (adventisthealthcare.com)
- Store acyclovir injection at room temperature away from moisture and heat. (adventisthealthcare.com)
- What should I avoid while using acyclovir injection? (adventisthealthcare.com)
- Finally, motility expiration acyclovir mechanisms, such as an intravitreal injection to treat parkinsons disease oxazepam (serax) anithistamines high blood pressure, and high cholesterol zofran long term use . (iahf.com)
- Aciclovir has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. (drugbank.ca)
- Reviews of research dating from the 1980s show there is some effect in reducing the number and duration of lesions if aciclovir is applied at an early stage of an outbreak. (wikipedia.org)
- In both parts, the duration of virus shedding and the time to crusting and healing of lesions were shorter among acyclovir recipients than among placebo recipients. (nih.gov)
- Your symptoms should improve during your treatment with acyclovir. (medlineplus.gov)
- Using acyclovir for cold sores has been proven most effective if it is applied early on as soon as the first symptoms of cold sores were felt (known as the Tingle stage). (coldsoreproof.com)
- To the editor: After reading the report of Wade and Meyers (1) and the letter of Vartian and Shlaes (2) on neurologic deterioration after intravenous acyclovir treatment, we write to report that we have seen a remarkable improvement of the neurologic symptoms in a patient with Behçet's syndrome who was treated with acyclovir. (annals.org)
- Each capsule of acyclovir contains 200 mg of acyclovir and the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, magnesium stearate and microcrystalline cellulose. (nih.gov)
- Using acyclovir for cold sores is not an assurance that outbreaks will never happen again in an exposed person's lifetime. (coldsoreproof.com)
- When taken as directed, Acyclovir helps speed up the healing process, reduces transmission risks, and helps minimize the risk of complications that can result from herpes outbreaks. (accessrx.com)
- Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). (nih.gov)
- The sodium salt form of acyclovir, a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. (cancer.gov)
- Acyclovir, a synthetic acyclic nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster specified thymidine kinase. (rxmed.com)
- Two 5-ounce glasses of wine a day are generally thought to be safe for people taking Acyclovir. (accessrx.com)
- What Happens When You Drink Alcohol While Taking Acyclovir? (accessrx.com)
- Heat, tiredness, stress, and hunger tend to worsen dizziness when taking Acyclovir, and alcohol consumption can amplify the effect even more. (accessrx.com)
- Taking Acyclovir , Words sort of fail me when I go to describe the character that is Marmaduke (it's unclear so far how he got his name. (unsoughtinput.com)
- doxycycline use for acne Buying Acyclovir In Amsterdam Netherlands Cheap . (r8sildenafil.com)
- but I'll go so far as to say that trying to figure out what the hell is up with Marmaduke is the #2 reason to watch the show, behind its association with Kids in the Hall, online buying Acyclovir . (unsoughtinput.com)
- Only 1 graft rejection event was observed, 15 years after implantation, and was successfully treated with systemic acyclovir and topical corticosteroids. (aao.org)
- There are no acyclovir adequate and well-controlled studies of ointment systemic acyclovir in ointment pregnant women. (sportsrubbish.com)
- A few reported cases of skin flushing, allergic inflammation, itching, stinging or burning sensations and skin drying has been associated with the use of Acyclovir. (coldsoreproof.com)
- Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. (medlineplus.gov)
- Acyclovir is a synthetic nucleoside analogue active against herpes viruses. (nih.gov)
- In general, the pharmacokinetics of acyclovir in children is similar to adults. (rxmed.com)
- 1 ml indeholder 25 mg aciclovir (som aciclovirnatrium). (medicin.dk)
- Very recently, utilization of higher doses of acyclovir for longer periods of time has been demonstrated to further improve the outcome of neonatal HSV disease. (aappublications.org)
- Consenting participants will be randomized to receive either acyclovir plus syndromic management or placebo plus syndromic management. (clinicaltrials.gov)
- therefore, 1 placebo subject and 6 acyclovir subjects are included in the analysis. (clinicaltrials.gov)
- A large PRCT with a real placebo control group is needed to clarify the effectiveness of acyclovir in the treatment of Bell's palsy. (bestbets.org)
- To the editor: We read the report of Wade and Meyers (1) with interest as we have also seen a case of transient neurologic deterioration associated with intravenous acyclovir. (annals.org)
- Please read all packaging before taking Aciclovir tablets. (chemistdirect.co.uk)