Acute Radiation Syndrome

Radioactive Hazard Release

Radiation Injuries, Experimental

Radiation Injuries

Whole-Body Irradiation

Radiation-Protective Agents

Radiation Dosage

Lethal Dose 50

Dose-Response Relationship, Radiation

Radiodermatitis

Syndrome

Radiation Pneumonitis

Electronic Mail

Food Dispensers, Automatic

Editorial Policies

Authorship

Periodicals as Topic

Postal Service

Internet

Nuclear Warfare

Japan

Foundations

Granulocyte Colony-Stimulating Factor

Acute radiation syndrome | definition of acute radiation syndrome by Medical dictionary

Acute radiation syndrome synonyms, Acute radiation syndrome antonyms - FreeThesaurus.com

Molecules | Free Full-Text | Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise...

Pluristem to Present Data on PLX-R18 in Treatment of Acute Radiation Syndrome at American Society of Hematologys Annual...

Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) Market : Forecast, Strategies, News & Demand | Medgadget

Acute radiation syndrome - WikiProjectMed

Acute Radiation Syndrome in an Irradiated Minipig Model for Patients with Radiation Exposure

Underexposed: What If Radiation is Actually Good for You?: Acute Radiation Syndrome

Convert Nausea And Vomiting (Acute Radiation Syndrome) to Hourly Average Background Radiation (Radiation Dose Examples)

Convert Death (Acute Radiation Syndrome) to Dental Radiology (Radiation Dose Examples)

Convert Death (Acute Radiation Syndrome) to Sievert (Sv, Dose Equivalent Radiation)

Convert Nausea And Vomiting (Acute Radiation Syndrome) to Millirem (Dose Equivalent Radiation)

PSRC - Donor-Recipient Chimeric Cell Transplantation as a Novel Rescue Therapy for Acute Radiation Syndrome: A Preliminary...

First global consensus for evidence-based management of the hematopoietic syndrome resulting from exposure to ionizing...

Chandan Guha, M.B.B.S., Ph.D. | Albert Einstein College of Medicine

BARDA Supports Proof-Of-Concept Studies for Small Molecule Development - PHE

Radiation injury, Ask a Doctor about diagnosis, treatment and medication for Radiation injury - Doctors insight on...

Plus it

Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation | Cell & Bioscience | Full...

Application of the micronucleus assay performed by different scorers in case of large-scale radiation accidents - Nukleonika -...

Radiation-induced cancer - Wikipedia

The Hemlock Tea Room and Ladies Emporium: WEST COAST WILL GET CONCENTRATED RADIATION. CANCERS WILL INCREASE

RLIP76 protein reduces 4-HNE generated during oxidative stress and results in protection in well characterized animal models of...

U.S. National Institutes of Health Recommend to Expand Its Scope of Research in the Development of Pluristems PLX-RAD Cells...

Models for the Development of Radiation Countermeasures (Review Paper) | Defence Science Journal

Pilot Study of Pluristems Radiation Countermeasure Shows Promising Results

Special Feature: Radiologic Hazards and Acute Radiation Exposure | 2004-07-01 | AHC Media: Continuing Medical Education...

UW EH&S - Tissue and Organ Effects of Acute Radiation Exposure

BfS - Acute radiation damage - Tissue Reactions

BfS - Acute radiation damage

IntechOpen Open Access Publisher - Open Science Open Minds | IntechOpen

NSWP launches global consensus statement for International Day To End Violence Against Sex Workers - Global Commission on HIV...

Practical Insights for Drug Development Using the Animal Rule

Medical Countermeasures

NIH issues solicitation for radiation medical countermeasures | BioPrepWatch

Prevention | Positive Now

Services

Global Advisory Committee Identifies Solutions for Addressing Top Lupus Barriers - World Lupus Federation

HRR - Task - Inter-Agency Medical Countermeasures Studies

Platforms for Rapid Integrated Solutions for Medical Countermeasures

Acute radiation syndrome - Radiation Effects Research Foundation

Mission to Mars would double astronauts cancer risk - WXOW News 19 La Crosse, WI - News, Weather and Sports

FDA gives Soligenix IND clearance for GI-ARS drug | BioPrepWatch

Ataxia Telangiectasia-Mutated Gene Polymorphisms and Acute Normal Tissue Injuries in Cancer Patients After Radiation Therapy: A...

Some Effects of X-irradiation on the Plasma Corticosterone, Adrenal Weights, and Differential Leukocyte Count in the Rat -...

First global consensus on the management of endometriosis « Endometriosis.org

Brain Death World Wide: Accepted fact but no global consensus in diagnostic criteria - HODS

Global Consensus Theorem and Self-Organized Criticality: Unifying Principles for Understanding Self-Organization, Swarm...

Bioterrorism as a Public Health Threat - Volume 4, Number 3-September 1998 - Emerging Infectious Disease journal - CDC

News Archive: April 2017 | International Alliance of Patients Organizations

Information and communication technologies (ICTs) | Poverty Eradication

Overview of emerging country-level response to providing educational continuity under COVID-19: Best practice in pedagogy for...

Emergent Unveils Expanded CIADM Facility for Medical Countermeasure Preparedness

NIAID Awards $47 Million in New Effort to Develop Medical Countermeasures Against Radiological and Nuclear Threats | Medgadget

trichology | Amy Ellis Nutt - Part 2

CNN.com - Transcripts

17 million grant to fund seizure, neurotoxin research

Heart rate

Ex-Rad

Ostra białaczka szpikowa, wolna encyklopedia

Sargramostim

Louis Slotin

Daigo Fukuryū Maru

Fukushima Daiichi nuclear disaster casualties

Fukushima Daiichi nuclear disaster casualties

Demon core

Nuclear testing at Bikini Atoll

Nuclear Power and the Environment

Alexander Litvinenko

Maria Orbeli

Radiobiology

Nuclear warfare

Dose fractionation

List of orphan source incidents

Aleksandr Akimov

Committed dose

Oishi Matashichi

Poisoning of Alexander Litvinenko

Eben Byers

Chernobyl disaster

Yuri Felshtinsky

Linear no-threshold model

Colonization of the asteroids

Setsuko Thurlow

Pluristem Therapeutics

Cleveland BioLabs

Heavy water

Hematopoietic stem cell transplantation

Chiropractic

Nephrology

腸梗阻 - 维基百科，自由的百科全书

Lactose intolerance

சொளிங்கர்-எலிசன் கூட்டறிகுறி - தமிழ் விக்கிப்பீடியா

White blood cell

Superoxide dismutase

Mosaic (genetics)

Urinary tract infection

Honey bee

پرتو کیهانی - ویکی‌پدیا، دانشنامهٔ آزاد

Necrotizing enterocolitis

Tetrahydrocannabinol

Branchio-oto-renal syndrome

Radiation therapy

Human digestive system

Influenza

Visible spectrum

Ketorolac

Angioedema

Health informatics

Mobile phone radiation and health

Nuclear and radiation accidents and incidents

Bat

Spigelian hernia

Ataxia

Bacillary dysentery

Thymus

Acute lymphoblastic leukemia

Sickness44

• Acute Radiation Syndrome (ARS) , or radiation sickness, is a serious illness that can happen when a person is exposed to very high levels of radiation, usually over a short period of time. (cdc.gov)
• Acute Radiation Syndrome (ARS) (sometimes known as radiation toxicity or radiation sickness) is an acute illness caused by irradiation of the entire body (or most of the body) by a high dose of penetrating radiation in a very short period of time (usually a matter of minutes). (cdc.gov)
• Acute radiation syndrome (ARS) , also called radiation sickness , is the result caused by receiving a dose greater than 75 rads (0.75 Gray (Gy)) of ionizing radiation [1] to the body in a short time (usually minutes). (citizendium.org)
• Acute radiation syndrome ( ARS ) also known as radiation poisoning , radiation sickness or radiation toxicity , is a syndrome or group of health effects which occur within months of exposure to high amounts of ionizing radiation . (wikipedia.org)
• Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection of health effects that are caused by being exposed to high amounts of ionizing radiation, in a short period of time. (wikipedia.org)
• These symptoms are common to many illnesses, and may not, by themselves, indicate acute radiation sickness. (wikipedia.org)
• Brooklyn, NY -- ( SBWIRE ) -- 03/06/2018 -- Qyresearchreports include new market research report "Global Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) Market Size, Status and Forecast 2025" to its huge collection of research reports. (sbwire.com)
• A newly added research report about the global market for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) produces a 360-degree overview of it. (sbwire.com)
• The various segments of the global market for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) have been discussed carefully at length. (sbwire.com)
• This enables it to find out the global market for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome)'s growth prospects. (sbwire.com)
• This helps to furnish a granular overview of the market for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) and the areas where main opportunities lie. (sbwire.com)
• This report studies the global Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) market, analyzes and researches the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) development status and forecast in United States, EU, Japan, China, India and Southeast Asia. (sbwire.com)
• A thorough examination of the competitive landscape of the global market for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) has also been provided in the report. (sbwire.com)
• Prominent participants in the global market for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) have been examined and data pertaining to their sales and revenues, among other things, have been presented. (sbwire.com)
• The primary intention of the report is to help the companies operating in the global market for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) to gain an insight into the current market dynamics, including opportunities and pitfalls that would enable them to strategize sagaciously. (sbwire.com)
• ARS is also known as radiation sickness or radiation toxicity. (drugster.info)
• Other names for Acute Radiation Syndrome are: Acute Radiation Sickness, Radiation Sickness , Radiation Poisoning and Radiation Toxicity. (epainassist.com)
• Also called radiation poisoning, radiation toxicity, or radiation sickness. (wikem.org)
• Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome)-Pipeline Insights, 2016", report provides in depth insights on the pipeline drugs and their development activities around the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome). (gosreports.com)
• DelveInsight's Report also provides detailed information on the discontinued and dormant drugs that have gone inactive over the years for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome). (gosreports.com)
• DelveInsight's Report also assesses the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) therapeutics by Monotherapy, Combination products, Molecule type and Route of Administration. (gosreports.com)
• This is known as acute radiation syndrome, commonly known as "radiation sickness. (epa.gov)
• Radiation sickness is damage to your body caused by a large dose of radiation often received over a short period of time (acute). (pharmacypedia.org)
• Radiation sickness is also called acute radiation sickness, acute radiation syndrome or radiation poisoning. (pharmacypedia.org)
• Common exposures to low-dose radiation, such as X-ray or CT examinations, don't cause radiation sickness. (pharmacypedia.org)
• Although radiation sickness is serious and often fatal, it's rare. (pharmacypedia.org)
• Since the atomic bombings of Hiroshima and Nagasaki, Japan, during World War II, most cases of radiation sickness have occurred after nuclear industrial accidents such as the 1986 fire that damaged the nuclear power plant at Chernobyl or the 2011 earthquake that damaged the nuclear power plant on the east coast of Japan. (pharmacypedia.org)
• The severity of signs and symptoms of radiation sickness depends on how much radiation you've absorbed. (pharmacypedia.org)
• Signs and symptoms of radiation sickness usually appear when the entire body receives an absorbed dose of at least 1 Gy. (pharmacypedia.org)
• The initial signs and symptoms of treatable radiation sickness are usually nausea and vomiting. (pharmacypedia.org)
• After the first round of signs and symptoms, a person with radiation sickness may have a brief period with no apparent illness, followed by the onset of new, more serious symptoms. (pharmacypedia.org)
• An accident or attack that causes radiation sickness would no doubt cause a lot of attention and public concern. (pharmacypedia.org)
• Radiation sickness is caused by exposure to a high dose of radiation, such as a high dose of radiation received during an industrial accident. (pharmacypedia.org)
• Radiation sickness occurs when high-energy radiation damages or destroys certain cells in your body. (pharmacypedia.org)
• A Japanese girl presenting the effects of radiation sickness. (gutenberg.org)
• These diseases are sometimes referred to as radiation sickness, but they are never included in the term acute radiation syndrome. (gutenberg.org)
• Symptoms may be local (eg, burns) or systemic (eg, acute radiation sickness). (merckmanuals.com)
• Patients with severe acute radiation sickness receive reverse isolation, antimicrobial and anti-inflammatory agents, and bone marrow support. (merckmanuals.com)
• Find out what you need to know about radiation sickness. (disasterassistance.gov)
• What are the treatments for acute radiation sickness? (medlineplus.gov)
• Radiation and the Human Body Dr. Richard Besser on the effects of radiation sickness. (go.com)
• Radiation sickness has haunted humanity since the atomic bombs dropped, killed entire teams of firefighters at the Chernobyl nuclear plant disaster and worries workers trying to fix the Fukushima reactor in Japan. (livescience.com)
• But no current treatment exists for radiation sickness, which is also known as acute radiation syndrome. (livescience.com)
• That matters because infections are what often end up killing victims of radiation sickness. (livescience.com)

Centers for Diseas3

• The SNS assembled a working group with representatives from the Centers for Disease Control and Prevention, the U.S. Armed Forces, and universities with expertise in acute radiation injury. (annals.org)
• Visit the U.S. Centers for Disease Control and Prevention (CDC) for more information about possible health effects of radiation exposure and contamination. (epa.gov)
• Centers for Disease Control and Prevention (2005) Cutaneous radiation injury: fact sheet for physicians. (springer.com)

Toxicity5

• Studies of therapy effects of Anti-radiation Immunoglobulin G in vivo have established that specific antibodies to Radiation Toxins of SRD group can be important, effective part of medical management of ARS and can play a significant role in neutralization of radiation induced toxicity. (radioprotection.org)
• Acute and repeated dose 28-day oral toxicity of Chrysobalanusicaco L. leaf aqueous extract. (bioportfolio.com)
• The acute toxicity study was performed using a dose of AECi 2000 mg/kg, while the repeated dose toxicity study, the AECi was administered daily at doses of 100, 200 and 400 mg/kg, for 28 days. (bioportfolio.com)
• Acute and 28-day repeated dose oral toxicity study of caraway oil in rats. (bioportfolio.com)
• Toxicological evaluation of naringin: Acute, subchronic, and chronic toxicity in Beagle dogs. (bioportfolio.com)

Nuclear31

• The market for radiation countermeasures has grown substantially, primarily due to the perceived threat of chemical, biological, radiation, and nuclear attacks. (yahoo.com)
• Information about the acute radiation syndrome comes from studies of animals, studies of accidents at nuclear power plants, or studies of the effects of the atomic bomb detonated over Hiroshima, Japan. (annals.org)
• Radiation sources can range from major radioactive materials, such as leaked nuclear fuel seen in the Fukushima Daiichi nuclear disaster, to common X‑ray machines. (army.mil)
• Examples of persons who suffered from acute radiation syndrome (ARS) are the survivors of the Hiroshima and Nagasaki atomic bombs and the firefighters that first responded after the Chernobyl Nuclear Power Plant event in 1986. (drugster.info)
• Acute radiation syndrome is rare, and comes from extreme events like a nuclear explosion or accidental handling or rupture of a highly radioactive source. (epa.gov)
• BARDA is seeking additional proposals for products that potentially could treat or illness and injury from acute radiation syndrome , as well as improved diagnostic tools to measure the radiation dose a person has absorbed after a nuclear denotation or radiation accident. (freethesaurus.com)
• Accidents involving nuclear reactors such as those that took place in 1986 at Chernobyl and at Fukushima Daiichi after the March 2011 tsunami raise major concerns about what happens if the worst occurs and large numbers of people are simultaneously exposed to high levels of radiation. (news-medical.net)
• Victims of nuclear disasters present with acute radiation syndrome as a result of exposure to ionizing radiation. (ps-rc.org)
• Pluristem Therapeutics Inc., a leading developer of placenta-based cell therapy products, has announced the positive results of a recently completed trial conducted by the U.S. National Institutes of Health (NIH) to evaluate PLX-R18 cells to treat bone marrow damaged by exposure to high levels of radiation, such as can occur after a nuclear disaster. (medicalnewstoday.com)
• Pluristem Therapeutics has announced that its new cell therapy to treat acute radiation syndrome (PLX-R18), based on the pioneering studies performed within the laboratory of Prof. Raphael Gorodetsky at the Hadassah Medical Center, has received clearance from the United States Food and Drug Administration to treat individuals who may have been acutely exposed to high-dose radiation as the result of a nuclear attack or accident. (hadassahinternational.org)
• TLR2 signaling results in nuclear factor-kappaB (NF-κB)-dependent upregulation of anti-apoptotic factors, anti-oxidants and cytokines, all of which have been implicated in radiation protection. (elsevier.com)
• Beck, H. L., Krey, P. W. Radiation Exposures in Utah from Nevada Nuclear Tests. (nap.edu)
• By Elana Ringler Israeli biotech firm Pluristem Therapeutics said it hopes its anti-radiation therapy will protect Fukushima workers decommissioning nuclear reactors and save lives in the future if ever a similar catastrophe occurs. (yahoo.com)
• We are living in an area which have a variety of threats including nuclear bombs and radiation catastrophes so we developed the product in mind that those may happen. (yahoo.com)
• In response to concerns over possible radiological or nuclear incidents, the Radiation and Nuclear Countermeasures Program within the National Institute of Allergy and Infectious Diseases (NIAID) was tasked by the U.S. Department of Health and Human Services to support development of medical countermeasures (MCM) to treat the acute and delayed injuries that can result from radiation exposure. (bioone.org)
• Radiation emergencies can happen because of a terrorist attack or an accident at a nuclear facility. (disasterassistance.gov)
• The websites below can help you learn how to prepare for a radiation or nuclear event and how you can keep yourself and your family safe during and after. (disasterassistance.gov)
• Learn the potential radiation exposure danger from a nuclear power plant emergency. (disasterassistance.gov)
• In contrast to the nontherapeutic radiologic/nuclear incidents and disaster scenarios discussed in the previous article in the series, 1 the present article explores issues associated with routine and accidental exposure from administration of ionizing radiation during routine clinical practice. (jaoa.org)
• Acute radiation syndrome in Russian nuclear workers. (cdc.gov)
• But many people remained concerned after Japan's Prime Minister Naoto Kan said the damaged nuclear reactors may spew further radiation. (go.com)
• Three nuclear plant workers have suffered from acute radiation syndrome, the New York Times reported. (go.com)
• The World Nuclear Association says the lowest level of radiation that is clearly at a carcinogenic level is 100 millisieverts per year. (go.com)
• Disasters such as those at the Fukushima Daiichi Nuclear Power Plant and the Chernobyl Nuclear Power Plant, emphasize the need for available and effective therapeutic options to mitigate and treat the damaging effects of exposure to lethal doses of ionizing radiation. (science.edu.sg)
• In all likelihood, the nuclear crisis playing out in Japan would be far worse if not for a crew of 50 to 100 workers braving explosions, heat and radiation. (livescience.com)
• John Lee, a professor of nuclear engineering at the University of Michigan, said that acceptable levels of radiation are typically much lower - 50 mSv per year - "but this limit may be exceeded somewhat in emergency situations. (livescience.com)
• Kim Kearfott, another professor of nuclear engineering at the University of Michigan, said there are a several radiation checkpoints in place to protect the workers. (livescience.com)
• This experience has provided epidemiologists useful data on radiation exposure," he said, adding that the nuclear crisis at the Fukushima plants is not yet on par with the Chernobyl disaster . (livescience.com)
• Machine generated contents note: Section I: For Students of Diagnostic Radiology, Nuclear Medicine, and Radiation Oncology 1. (helsinki.fi)
• Part I contains 17 chapters and represents both a general introduction to radiation biology and a complete self-contained course in the subject, suitable for residents in diagnostic radiology and nuclear medicine. (helsinki.fi)
• About 50 to 100 Japanese workers risked radiation and explosions to prevent complete meltdown of nuclear reactors at the Fukushima plant. (livescience.com)

Levels of radiation14

• These studies demonstrated PLX-R18 potential to increase survival rates after radiation exposure, as well as protect and regenerate the bone marrow's ability to produce blood cells, crucial for victims exposed to high levels of radiation. (apnews.com)
• Exposure to low levels of radiation encountered in the environment does not cause immediate health effects, but is a minor contributor to our overall cancer risk. (epa.gov)
• Exposure to low-levels of radiation does not cause immediate health effects, but can increase the risk of cancer over a lifetime. (epa.gov)
• Injection of PLX-R18 cells into muscle, as compared to a placebo , resulted in a statistically significant improvement in the recovery of white blood cell, red blood cell, and platelet levels in animals exposed to high levels of radiation. (medicalnewstoday.com)
• High levels of radiation can destroy the body's ability to produce these three blood lineages, and rapidly regaining that capacity is a key factor in surviving the hematologic component of acute radiation syndrome (ARS), a condition caused by high-dose irradiation that can involve severe, sometimes lethal damage to the bone marrow as well as other physiologic systems and organs. (medicalnewstoday.com)
• Our PLX-R18 cell product was developed and targeted to become a strong candidate for government procurement programs designed to protect the population in the case of exposure to dangerous levels of radiation. (medicalnewstoday.com)
• The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. (globenewswire.ca)
• These findings, which show recovery of the hematologic system, suggest that PLX-R18 has the potential to treat a large population exposed to different levels of radiation and might also be used for additional hematologic indications. (globenewswire.ca)
• For example, Pluristem is using forward-looking statements when its discusses that PLX-R18 has the potential to treat a large population exposed to different levels of radiation and might also be used for additional hematologic indications, and the potential market for such indications. (globenewswire.ca)
• The scientists say that exposure to higher levels of radiation raises lifetime cancer risk 'slightly' . (medicalnewstoday.com)
• The effect of the treatment has been tested on different levels of radiation, including a level of radiation that could cause up to 70 percent mortality rate, Lukasiewicz Hagai said. (yahoo.com)
• Exposure to low levels of radiation in the environment does not cause immediate health effects. (medlineplus.gov)
• Such a therapy might even work up to several days after exposure to dangerous levels of radiation , according to Ram Mandalam, president and CEO of Cellerant Therapeutics. (livescience.com)
• But the biotech company soon found that the treatment worked well enough in its two Phase I clinical safety trials to possibly defend against higher levels of radiation. (livescience.com)

Symptoms31

• If you have these symptoms after a radiation emergency, seek medical attention as soon as emergency officials determine it is safe to do so. (cdc.gov)
• After the initial symptoms, a person usually looks and feels healthy for a period of time, after which he or she will become sick again with variable symptoms and severity that vary depending on the radiation dose that he or she received. (cdc.gov)
• the full syndrome will usually occur with a dose greater than approximately 0.7 Gy (70 rads) although mild symptoms may occur as low as 0.3 Gy or 30 rads. (cdc.gov)
• In this stage the symptoms depend on the specific syndrome and last from hours up to several months. (citizendium.org)
• The signs and symptoms of this form of radiation injury include nausea, vomiting, loss of appetite, and abdominal pain. (wikipedia.org)
• These symptoms may occur at radiation doses as low as 0.35 grays (35 rad). (wikipedia.org)
• Cutaneous radiation syndrome (CRS) refers to the skin symptoms of radiation exposure. (wikipedia.org)
• Except for vomiting, these signs and symptoms are closely related to frequency of cell division, rapid cell division being more sensitive to radiation than slow division (e.g., muscle and nerve cells). (rerf.jp)
• Published information supports a strategy in which health care providers first assess the radiation dose to an individual patient on the basis of symptoms and blood counts during the days after exposure. (annals.org)
• Symptoms and consequences of the acute radiation syndrome vary depending on the amount of exposure but can include nausea, vomiting, diarrhea, confusion, skin burns, low blood pressure or shock, infections, breathing difficulty, and death. (annals.org)
• Onset of the symptoms and the type of symptoms depends on the radiation exposure. (epainassist.com)
• If the patient has had comparatively smaller doses of radiation exposure then he/she will experience gastrointestinal symptoms, such as nausea and vomiting. (epainassist.com)
• The severity of symptoms occurring in Acute Radiation Syndrome depends on the amount of radiation absorbed by the patient. (epainassist.com)
• Symptoms of Acute Radiation Syndrome also depend on the type of radiation exposure for example if a part of the body has been exposed or if the complete body has been exposed to the radiation. (epainassist.com)
• The sensitivity of the affected tissues also determines the intensity of the symptoms of Acute Radiation Syndrome. (epainassist.com)
• Symptoms of Acute Radiation Syndrome appear when the complete body receives and absorbs a radiation dose of a minimum of 1 Gy. (epainassist.com)
• The greater the radiation exposure, the more severe and rapid are the symptoms of acute radiation exposure. (epainassist.com)
• Nausea and vomiting comprise of the initial signs and symptoms of acute radiation syndrome, which is treatable. (epainassist.com)
• [3] The speed of onset of symptoms is related to radiation exposure, with greater doses resulting in a shorter delay in symptom onset. (mdwiki.org)
• A very high level of radiation exposure delivered over a short period of time can cause symptoms such as nausea and vomiting within hours and can sometimes result in death over the following days or weeks. (epa.gov)
• Signs and symptoms also are affected by the type of exposure - such as total or partial body and whether contamination is internal or external - and how sensitive to radiation the affected tissue is. (pharmacypedia.org)
• The amount of time between exposure and when these symptoms develop is an indicator of how much radiation a person has absorbed. (pharmacypedia.org)
• In general, the greater your radiation exposure, the more rapid and more severe your symptoms will be. (pharmacypedia.org)
• Immediately after exposure, the most critical components of acute radiation syndrome are the hematopoietic (bone marrow) and early-onset gastrointestinal (GI) syndromes because symptoms begin very quickly and can be lethal. (freethesaurus.com)
• Similar symptoms may appear months to years after exposure as chronic radiation syndrome when the dose rate is too low to cause the acute form. (gutenberg.org)
• The person's symptoms will vary depending on the level of radiation they received, but some of the symptoms include loss of appetite, fatigue, fever, nausea, vomiting, diarrhea, and possibly even seizures and coma. (health.com)
• Diagnosis is by history of exposure, symptoms and signs, and sometimes use of radiation detection equipment to localize and identify radionuclide contamination. (merckmanuals.com)
• Curious because Arafat didn't demonstrate the classic symptoms of acute radiation syndrome . (wired.com)
• How soon they get sick again, which symptoms they have, and how sick they get depends on the amount of radiation they received. (medlineplus.gov)
• They will ask about your symptoms, do blood tests, and may use a device that measures radiation. (medlineplus.gov)
• For all forms of the syndrome, the most common presenting symptoms and signs, occurring in more than two thirds of patients, include the following: abdominal pain (particularly originating in the right upper quadrant), abdominal distension with ascites and hepatomegaly. (clinicaladvisor.com)

Hematopoietic-acute radiatio1

• There are no FDA-approved drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic-acute radiation syndrome (H-ARS). (indigobiosciences.com)

Injuries15

• The entire body (or a significant portion of it) must have received the dose.3 o Most radiation injuries are local, frequently involving the hands, and these local injuries seldom cause classical signs of ARS. (cdc.gov)
• We are pleased to see interest from key governmental agencies such as NIAID, the U.S Department of Defense and BARDA in our novel regenerative medical countermeasure for radiation injuries and look forward to potentially supporting such medical needs of the U.S. government. (apnews.com)
• For example, Pluristem is using forward-looking statements when it states its belief that, as a result of its meeting with the FDA, it has a clear and efficient path towards advancing the development of PLX-R18 in the treatment of ARS and its potential support of the U.S. government with respect to its medical needs relating to radiation injuries. (apnews.com)
• At development leukemia at ARS survivors, "hyperregeneration" - hemopoesis with increasing of neutrophils amount (in the absence of consequences of local radiation injuries) within the first years after an irradiation can form a basis for leukogenic transformation. (radioprotection.org)
• Cell technologies for replacement of skin defects at the patient with local radiation injuries. (radioprotection.org)
• Colwell CB: Radiation injuries, in Marx JA, Hockberger RS, Walls RM, et al (eds): Rosen's Emergency Medicine: Concepts and Clinical Practice, ed 8. (wikem.org)
• WASHINGTON -- Two contracts for advanced development of drugs to treat skin and lung injuries associated with acute radiation syndrome (ARS) were awarded this week by the U. (freethesaurus.com)
• A clear attribution of causes of death to burns, injuries or radiation was impossible because the shock and heat waves also had to be taken into account. (bfs.de)
• On the basis of a manual published recently by the Norwegian Center for NBC Medicine, Oslo University Hospital Ullevål, a centre for disaster medicine, we here present the main principles for medical treatment of radiation injuries - from first aid at the scene of injury to hospital treatment. (tidsskriftet.no)
• Our novel approach of DRCC transplantation may act as a bridging therapy supporting hematopoietic recovery and ameliorating injuries in patients exposed to the harmful effects of radiation. (ps-rc.org)
• For these reasons, the NIAID and the Radiation Injury Treatment Network organized a workshop to explore the use of growth factors and other cytokines as MCMs in the treatment of radiation-induced injuries. (bioone.org)
• Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs. (iu.edu)
• Berger ME, Christensen DM, Lowry PC et al (2006) Medical management of radiation injuries: current approaches. (springer.com)
• In the third of 5 articles on the management of injuries and illnesses caused by ionizing radiation, the authors provide a clinically relevant overview of the pathophysiologic process associated with potential exposure to ionizing radiation. (jaoa.org)
• To appreciate the systemic pathophysiologic process of ionizing radiation injuries and illnesses, it is necessary to understand how ionizing radiation causes subcellular, cellular, tissue, and organ damage. (jaoa.org)

Emergencies2

• New York State Potassium Iodide (KI) and Radiation Emergencies: Fact Sheet. (wikem.org)
• Read frequently asked questions about the use of KI in radiation emergencies. (disasterassistance.gov)

Gastrointestinal15

• It is generally divided into three types: bone marrow, gastrointestinal, and neurovascular syndrome, with bone marrow syndrome occurring at 0.7 to 10 Gy, and neurovascular syndrome occurring at doses that exceed 50 Gy. (wikipedia.org)
• Each syndrome requires that the tissue showing the syndrome itself be exposed (e.g., gastrointestinal syndrome is not seen if the stomach and intestines are not exposed to radiation). (wikipedia.org)
• Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. (mdpi.com)
• Exposure to ionizing radiation can lead to cellular DNA damage that can cause health issues such as cancer, diabetes, heart disease, lung fibrosis, liver fibrosis, kidney fibrosis, and acute radiation syndrome (ARS), which affects the hematopoietic and gastrointestinal systems. (army.mil)
• There are three ARS syndromes: the bone marrow syndrome (or hematologic syndrome), the gastrointestinal (GI) syndrome, and the cardiovascular (CV)/ central nervous system (CNS) syndrome. (drugster.info)
• Parts of the body, which are most vulnerable to the high dose radiation, are cells that line the gastrointestinal tract and the cells, which produce bone marrow. (epainassist.com)
• As mentioned before, the bone marrow and the gastrointestinal system are extremely sensitive to radiation. (epainassist.com)
• The gastrointestinal syndrome is not seen if the stomach and intestines are not exposed to radiation. (mdwiki.org)
• For instance, the gastrointestinal system and bone marrow are highly sensitive to radiation. (pharmacypedia.org)
• Soligenix is also developing OrbeShield(TM) for the treatment of gastrointestinal acute radiation syndrome (GI ARS) under a BARDA contract award valued up to $26. (freethesaurus.com)
• In response to an invitation from the Biomedical Advanced Research and Development Authority (BARDA), we submitted a contract proposal to support the development of OrbeShield (TM) for the treatment of gastrointestinal acute radiation syndrome (GI ARS), which if awarded, has the potential to be a multi-million dollar contract. (freethesaurus.com)
• In cell and animal models, Ex-RAD protects hematopoietic and gastrointestinal tissues from radiation injury when given either before or after exposure. (wikipedia.org)
• Pluristem Therapeutics' Vice President of Medical and Clinical Affairs Dr. Esther Lukasiewicz Hagai said cells grown from placentas donated by women who had undergone a C-section, are harvested to create a cocktail of therapeutic proteins which combat potentially lethal damage to the lungs, skin, bone marrow and gastrointestinal tract caused by radiation exposure. (yahoo.com)
• Infections caused by ionizing radiation can be endogenous, originating from the oral and gastrointestinal bacterial flora, and exogenous, originating from breached skin following trauma. (wikipedia.org)
• The patient that develops neutropenia after radiation is susceptible to irradiation damage to other tissues, such as the gastrointestinal tract, lungs and the central nervous system. (wikipedia.org)

Doses of radiation8

• ARS differs from chronic radiation syndrome, which occurs following prolonged exposures to relatively low doses of radiation. (wikipedia.org)
• During the studies, animals were injected intravenously with either PLX cells or a placebo, on the day after being exposed to lethal doses of radiation. (hadassah.org)
• Death of laboratory animals had occurred within 5 min-3 days after injection of toxic doses of Radiation Neuro-Toxin and depended on a concentration and a type of active substance of Radiation Toxins. (radioprotection.org)
• Hyper-immunization of non-irradiated animals by non-toxic doses of Radiation Toxins were provided. (radioprotection.org)
• Acute radiation syndrome refers to the acute medical problems, which the patient experiences within 24 hours of exposure to extremely high or lethal doses of radiation. (epainassist.com)
• Neulasta is indicated to increase survival in patients acutely exposed to myelosuppressive doses of radiation [see DOSAGE AND ADMINISTRATION and Clinical Studies ]. (rxlist.com)
• In particular, this irradiator is dedicated more specifically to the fields of radiobiology, the adverse effects of interventional radiology, the adverse effects of high doses of radiation delivered during certain types of radiotherapy, especially stereotactic radiation therapy. (irsn.fr)
• Exposure to higher doses of radiation is associated with systemic anaerobic infections due to gram negative bacilli and gram positive cocci. (wikipedia.org)

Countermeasure2

• It is being developed as a radiation countermeasure to prevent death from Acute Radiation Syndrome (ARS). (yahoo.com)
• Filgrastim ('Neupogen') a hematopoietic countermeasure of acute radiation syndrome (ARS). (wikipedia.org)

Granulocyte-macrop1

• The well-documented effect of the growth factors (granulocyte colony-stimulating factor [G-CSF] and granulocyte-macrophage colony-stimulating factor [GM-CSF]) in acute radiation injury has become standard treatment for ARS in the United States, based on the fact that growth factors increase number and functions of both macrophages and granulocytes. (dovepress.com)

Exposures2

• Breast cancer incidence in U.S. radiologic technologists is elevated in those who experienced daily low-dose radiation exposures over several years that potentially resulted in appreciable cumulative exposure. (greenmedinfo.com)
• The pilot research was carried out with DOE support (January 1997) to evaluate the possibility of applying primary clinical and dosimetry data available at FIB-l and Mayak P A to the study of deterministic effects from occupational radiation exposures. (cdc.gov)

Hematologic acute ra1

• We examined the utility of blood cell counts (BCCs) in the first three days postirradiation to predict clinical outcome, specifically for hematologic acute radiation syndrome (HARS). (nih.gov)

Radioactive16

• The increased risk of terrorist acts that could involve the use of radioactive sources calls for us to be prepared that a major radiation incident may occur in our country as well. (tidsskriftet.no)
• The changed threat picture, with an increased risk of terrorist acts involving the use of radioactive sources ( 2 , 3 ), calls for the preparation of clear plans for responses to major radiation incidents. (tidsskriftet.no)
• This was used for a theoretical exercise arranged by the Norwegian Radiation Protection Authority in 2008, the scenario for which was that members of a terrorist organization had placed a radioactive source under a seat in an underground train. (tidsskriftet.no)
• Another possible use of a radiation source for terrorist purposes involves so-called «dirty bombs», i.e. conventional explosives mixed with radioactive material. (tidsskriftet.no)
• The manual describes principles for assessment of the scene of injury in the case of radiation accidents, criteria for selection of patients with regard to their treatment priority (triage), procedure for decontamination of patients who have been exposed to radioactive pollution and guidelines for medical treatment. (tidsskriftet.no)
• In a radiation accident, a distinction is made between external radiation from a point source and the radioactive pollution described above. (tidsskriftet.no)
• Individuals should drink plenty of fluids and void frequently to promote dilution of the radioactive chelate in the urine and minimize radiation exposure directly to the bladder. (rxlist.com)
• Because dialysis fluid will become radioactive, radiation precautions must be taken to protect personnel, other patients, and the general public. (rxlist.com)
• Ionizing radiation is emitted by radioactive elements and by equipment such as x-ray and radiation therapy machines. (merckmanuals.com)
• This energetic radioactive element emits alpha radiation which does not penetrate the skin so that it can be safely carried by an assassin. (wired.com)
• Last July, Al Jazeera published test results from the Institute for Radiation Physics in Lausanne, Switzerland which had found such circumstantial radioactive evidence in his clothing and other effects. (wired.com)
• ABC News contacted a dozen experts on radiation and, while most said that it is unlikely that the radioactive material will have severe health repercussions on those in Fukushima for now, doctors also agreed that it is too early to tell what will happen as the situation continues. (go.com)
• The Japanese government has dispensed more than 200,000 units of potassium iodide , a drug commonly used to treat low-level radiation exposure, which would block radioactive iodine to prevent thyroid cancers. (go.com)
• This article lists notable civilian accidents involving radioactive materials or involving ionizing radiation from artificial sources such as x-ray tubes and particle accelerators . (wikipedia.org)
• The damage must be related directly to radioactive materials or ionizing radiation from a man-made source, not merely taking place at a facility where such are being used. (wikipedia.org)
• She was known to carry test tubes full of radioactive isotopes in her pocket, and to store them in her desk drawer, resulting in massive exposure to radiation. (wikipedia.org)

Myeloid2

• This is a Phase I, open-label, multi-center, dose-escalation study of lenalidomide in adult patients with newly diagnosed, relapsed or refractory acute myeloid leukemia. (bioportfolio.com)
• acute myeloid leukemia lub acute myelogenous leukemia , AML lub acute non-lymphoblastic leukemia , ANLL ) - grupa chorób spowodowana nowotworowym rozrostem w szpiku wczesnych komórek prekursorowych krwi. (wikipedia.org)

Chronic6

• The most typical is development of acute leukemia and chronic myelogenic leukemia 5-10 years later radiation exposure. (radioprotection.org)
• Development Ph-positive chronic myelogenic leukemia has occurred later - after 21 year after radiation exposure. (radioprotection.org)
• MRLs are derived for acute (1-14 days), intermediate (15-364 days), and chronic (365 days and longer) durations and for the oral, inhalation, and external routes of exposure. (cdc.gov)
• Chronic changes can be a result of long-term low-level exposure or the sequelae of a single episode of high-dose radiation. (springer.com)
• Those presenting with fulminant and acute forms are more likely to be female and one third or more present with jaundice or with altered mental status due to hepatic encephalopathy, which are both uncommon in subacute and chronic BCS. (clinicaladvisor.com)
• Subacute or chronic BCS, which is more common than the acute forms in most reported series, should be considered in all patients presenting with unexplained liver disease. (clinicaladvisor.com)

Bone marrow syndrome1

• The bone marrow syndrome is characterized by anorexia (lack of appetite), fever, and malaise. (drugster.info)

Exposure and contamination1

• Adapted from Radiation exposure and contamination. (pharmacypedia.org)

Component of acute radiatio1

• The TBI dose ranges against which sLP are effective indicate that sLP primarily impact the hematopoietic (HP) component of acute radiation syndrome. (elsevier.com)

Management of acute radiatio2

• Working groups on the management of acute radiation syndrome have been established [ 2 , 3 ]. (mdpi.com)
• Dainiak N. Medical management of acute radiation syndrome and associated infections in a high-casualty incident . (nlm.gov)

Occurs11

• ARS occurs when the body is exposed to radiation in excess of four sieverts (the biological dose equivalent of radiation). (sciencephoto.com)
• This syndrome typically occurs at absorbed doses greater than 30 grays (3,000 rad), though it may occur at 10 grays (1,000 rad). (wikipedia.org)
• Moreover, since our previous work indicated that PLX cells can enhance the engraftment of hematopoietic stem cells from cord blood, we can offer a multifaceted approach to reduce and treat the destruction of bone marrow that occurs following exposure to high-dose ionizing radiation. (hadassah.org)
• Acute radiation syndrome involves a total dose of greater than 0.7 Gy (70 rads), that generally occurs from a source outside the body within minutes. (mdwiki.org)
• Acute radiation syndrome occurs when a person is exposed to a high dose of external penetrating radiation within a short time. (medindia.net)
• Principal investigator Melpo Christofidou-Solomidou of the Perelman School of Medicine at the University of Pennsylvania and colleagues found that a diet of flaxseed given to mice not only protects lung tissues before exposure to radiation, but also can significantly reduce damage after exposure occurs. (medindia.net)
• Exposure to harmful radiation occurs very rarely in our country, and only one case resulting in serious health injury is known to date ( 1 ). (tidsskriftet.no)
• According to the CDC , acute radiation syndrome occurs when a person is exposed to a very high level of radiation in a short period of time. (health.com)
• Population exposure to ionizing radiation mainly occurs from natural sources or from medical devices. (springer.com)
• Acute, high-dose exposure usually occurs due to accidental exposure and can lead to significant immediate and long-term medical problems. (springer.com)
• If such an event occurs, those trained in the radiation sciences will be called on to manage exposed individuals. (helsinki.fi)

Contamination1

• If you were exposed to certain types of radiation, your provider may give you a treatment that limits or removes the contamination that is inside your body. (medlineplus.gov)

Accidents8

• Radiation accidents are fortunately infrequent but their health consequences are serious and they have the potential of resulting in large-scale events [ 1 ]. (mdpi.com)
• We analyzed BCC test samples from radiation accident victims (n = 135) along with their clinical outcome HARS severity scores (H1-4) using the System for Evaluation and Archiving of Radiation Accidents based on Case Histories (SEARCH) database. (nih.gov)
• In Korea , there were repeated radiation exposure accidents among non-destructive testing workers . (bvsalud.org)
• Strict legal amendments to safety procedures are essential to prevent repeated radiation exposure accidents . (bvsalud.org)
• The committee said that the six people's deaths were linked to either previous health problems or non-radiation accidents. (medicalnewstoday.com)
• Fliedner TM, Friescke I, Beyrer K (2001) Medical management of radiation accidents: manual on the acute radiation syndrome. (springer.com)
• Mettler FA, Kelsey CA, Ricks RC (1990) Medical management of radiation accidents. (springer.com)
• Oak Ridge Institute for Science and Education, ORISE-EHSD-REAC/TS (2000) Radiation accidents registries. (springer.com)

Ionizing27

• The radiation must be penetrating [i.e., ionizing]. (citizendium.org)
• Regulation of ERβ-mediated gene expression by genistein dictates the extent, severity, and response to DNA damage from ionizing radiation, which confer a radioresistant state to healthy cells. (army.mil)
• Acute illness caused by exposure to high doses (at least 1 Gy) [1] of ionizing radiation over a short period of time. (wikem.org)
• Ionizing radiation Radiation with so much energy it can knock electrons out of atoms. (epa.gov)
• Ionizing radiation can affect the atoms in living things, so it poses a health risk by damaging tissue and DNA in genes. (epa.gov)
• EPA bases its regulatory limits and nonregulatory guidelines for public exposure to low level ionizing radiation on the linear no-threshold (LNT) model. (epa.gov)
• Ionizing radiation can damage living tissue in the human body. (medindia.net)
• Transplantation of DRCC after ionizing radiation exposure proved to be the most effective rescue therapy against acute radiation syndrome, as confirmed by 100% of recipients' survival and expedited recovery of the hematopoietic system without developing GVHD. (ps-rc.org)
• Effect on intelligence test score of prenatal exposure to ionizing radiation in Hiroshima and Nagasaki: A comparison of the T65DR and DS86 dosimetry systems. (cdc.gov)
• Herein, we report a case of acute radiation syndrome caused by short periods of high exposure to ionizing radiation . (bvsalud.org)
• Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (merckmanuals.com)
• One of the IRSN's missions consists of evaluating the risks related to the use of ionizing radiation in the medical sphere and in accidental situations. (irsn.fr)
• The images are then used to plan treatment using the Muriplan software, which provides for the most appropriate adaptation of distribution of the dose of ionizing radiation to the region we want to irradiate, thus mimicking the irradiation conditions met during application of clinical radiotherapy protocols. (irsn.fr)
• Anno GH, Young RW, Bloom RM et al (2003) Dose response relationships for acute ionizing-radiation lethality. (springer.com)
• EC (1996) Council Directive 96/29/Euratom of 13 May 1996 of the European Union laying down basic safety standards for the protection of the health workers and the general public against the dangers arising from ionizing radiation. (springer.com)
• Health and Safety Executive Ionizing radiation. (springer.com)
• IAEA (1996) IAEA safety series: international basic safety standards for protection against ionizing radiation and for the safety of radiation sources. (springer.com)
• Karagas MR, Mc Donald JA, Greenberg ER et al (1996) Risk of basal cell and squamous cell skin cancers after ionizing radiation therapy. (springer.com)
• In: Medical effects of ionizing radiation. (springer.com)
• Ionizing radiation exposure can induce profound changes in intracellular components, potentially leading to diverse health effects in exposed individuals. (jaoa.org)
• Purposeful exposure of patients to ionizing radiation has been a staple in the practice of medicine since the use of the first x-rays more than 100 years ago. (jaoa.org)
• Whether for general radiologic study or for targeted administration in cancer therapy, most physicians will, on a daily basis, encounter a patient who has been exposed to ionizing radiation. (jaoa.org)
• Mettler FA Jr, Upton AC: Medical Effects of Ionizing Radiation, 3rd ed. (nlm.gov)
• Therefore, we also included a chapter on fundamental concepts in molecular imaging that involves ionizing radiation such as CAT scans and PET imaging to reflect these new advances and describe the underlying biologic principles for each of these technologies (Chapter 15). (helsinki.fi)
• Infections caused by exposure to ionizing radiation can be extremely dangerous, and are of public and government concern. (wikipedia.org)
• Numerous studies have demonstrated that the susceptibility of organisms to systemic infection increased following exposure to ionizing radiation. (wikipedia.org)
• Organisms causing sepsis following exposure to ionizing radiation: The management of established or suspected infection following exposure to radiation (characterized by neutropenia and fever) is similar to that used for other febrile neutropenic patients. (wikipedia.org)

Myelodysplastic3

• Our objective was to measure myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) risk associated with radiation and/or chemotherapy breast cancer (BC) treatment. (biomedcentral.com)
• Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: a study of the Hoosier Oncology Group. (iu.edu)
• ONTX is conducting a pivotal Phase 3 trial of rigosertib under a Special Protocol Assessment, or SPA, from the U.S. Food and Drug Administration, or FDA, for higher risk myelodysplastic syndromes, or MDS. (equities.com)

Occur9

• Cleveland Biolab's development efforts are related to apoptosis, a regulated form of cell death that can occur in response to exposure to radiation or toxic chemicals. (yahoo.com)
• If the radiation injury itself is fatal, death will occur in no more than a few months. (citizendium.org)
• Sources of such radiation can occur accidentally or intentionally. (wikipedia.org)
• Illnesses collectively called 'acute radiation syndrome' occur within a few hours to months after exposure to high-dose radiation (from approximately 1-2 Gy to 10 Gy). (rerf.jp)
• If the radiation dose is low, the syndrome will seldom if ever occur. (rerf.jp)
• Exposure to a high dose of radiation, which can occur in an industrial accident, will cause Acute Radiation Syndrome. (epainassist.com)
• Acute radiation syndrome can occur at 1Sv (1000mSv). (medicalnewstoday.com)
• Radiation can occur naturally or be man-made. (medlineplus.gov)
• Biologically, our cells have mechanisms to repair the kind of small amounts of damage that occur daily due to background radiation and other causes, so it is quite possible, even likely, that doses below a certain point do not have the effect of causing increased cancer risk," said David Rocke, distinguished professor of biostatistics at the University of California, Davis. (go.com)

Severity1

• The new data were to be used to test the triage scheme that had been developed by Thoma and Wald in 1959 to provide clinicians without any special knowledge about radiation effects with early diagnostic and prognostic information about the severity of such injury as a basis for medical management. (cdc.gov)

Patients17

• 4 o The survival rate of patients with this syndrome decreases with increasing dose. (cdc.gov)
• Unless the exposure causing the syndrome was caused by a well-understood incident to a small number of people, patients presenting with the syndrome should cause an emergency management response. (citizendium.org)
• What does the SNS Radiation Working Group suggest that patients and doctors do? (annals.org)
• BIO 300 Oral Suspension is being developed as a supportive care agent for cancer patients undergoing radiation therapy via self-administration with pre-loaded oral syringes, and is currently being evaluated in a Phase 1b/2a clinical trial (NCT02567799). (army.mil)
• Over the next few months, Prof. Gorodetsky and his team will focus on better understanding the PLX cells' mechanism of action as an "off the shelf" post radiation treatment, which could potentially be used in the future for treating ARS patients. (hadassah.org)
• Rapid clinical triage of radiation injury patients is essential for determining appropriate diagnostic and therapeutic interventions. (nih.gov)
• Clinical outcome of radiation injury patients can be rapidly predicted within the first three days postirradiation using peripheral BCC. (nih.gov)
• 5790 TNM stage 0-III patients treated with surgery alone, radiation and/or chemotherapy were included. (biomedcentral.com)
• In the current study we report the incidence of MDS and AML in breast cancer patients treated with surgery alone, surgery plus radiation and/or chemotherapy and compare the rates to those obtained from SEER incidence data. (biomedcentral.com)
• Use of the OBI for Neulasta is not recommended for patients with Hematopoietic Subsyndrome of Acute Radiation Syndrome . (rxlist.com)
• 90% of the breast cancers in Hodgkin's lymphoma patients receiving radiation are due to radiotherapy-associated uses. (greenmedinfo.com)
• Breast cancer risk may increase in patients exposed to therapeutic ionising radiation. (greenmedinfo.com)
• The Haifa-based company said they have developed a placenta-based cell therapy injection that can fully cure patients with multiple organ failure caused by high radiation exposure. (yahoo.com)
• The curriculum covers emergency department preparedness for receiving multiple pediatric patients, and conducting an acute assessment, diagnosis and stabilization of the severely injured child. (constantcontact.com)
• Because they have not yet had time to develop venous collaterals and they often have involvement of all the major hepatic veins, patients with acute BCS tend to be more symptomatic, often with intractable ascites and evidence of hepatic necrosis. (clinicaladvisor.com)
• Cellerant Therapeutics first considered CLT-008 as a way to boost the immune system of patients who receive radiation as part of chemotherapy for cancer. (livescience.com)
• 14 patients with nasopharyngeal carcinoma with 15 carotid blowout syndromes, initially treated by RT alone. (wikibooks.org)

Irradiation4

• Multiple-organ failure at Acute Radiation Syndromes is a major cause of mortality after high doses of gamma irradiation. (radioprotection.org)
• ARS is developed after a patient is exposed to high amounts of radiation in a short period of time, breaking down immature parenchymal stem cells in tissues due to the irradiation of the entire body. (raredr.com)
• In the passive avoidance and object recognition memory test, mice trained for 1 day after acute irradiation (2 Gy) showed significant memory deficits compared with sham controls. (bvsalud.org)
• Therefore, GT may attenuate memory defects in adult mice exposed to a relatively low dose of radiation possibly by inhibiting the detrimental effects of irradiation on hippocampal neurogenesis . (bvsalud.org)

20192

• HAIFA, Israel, Jan. 03, 2019 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (Nasdaq:PSTI) (TASE:PSTI), a leading regenerative medicine company developing novel placenta-based cell therapy products, today announced it has concluded a positive meeting with the U.S. Food and Drug Administration (FDA) regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). (apnews.com)
• Data will be jointly presented at the upcoming 2019 Radiation Injury Treatment Network (RITN) Workshop on July 31st HAIFA, Israel, July 17, 2019 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (thestreet.com)

Efficacy2

• Human efficacy studies to evaluate radiation medical countermeasures are not ethical, thus these studies are designed to meet the FDA's guidance for approval under the Animal Rule. (army.mil)
• Immunoglobulines to Radiation Toxins were used for a treatment of Acute Radiation Syndromes and the efficacy of this bio-pharmaceutical agent was initially evaluated. (radioprotection.org)

Renal insufficiency1

• Renal disorders, acute renal insufficiency - measurement of GFR based on kinetics of renal inulin excretion. (muni.cz)

Dose of radiation7

• Cutaneous Radiation Injury (CRI) happens when exposure to a large dose of radiation causes injury to the skin. (cdc.gov)
• The chance of survival decreases with increasing dose of radiation. (drugster.info)
• The dose of radiation that is absorbed by the body is measured in gray (Gy). (epainassist.com)
• The absorbed dose of radiation is measured in a unit called a gray (Gy). (pharmacypedia.org)
• Diagnostic tests that use radiation, such as an X-ray, result in a small dose of radiation - typically well below 0.1 Gy, focused on a few organs or small amount of tissue. (pharmacypedia.org)
• When a person has experienced known or probable exposure to a high dose of radiation from an accident or attack, medical personnel take a number of steps to determine the absorbed radiation dose. (pharmacypedia.org)
• But certain death from a high dose of radiation may finally vanish with a stem cell-based cellular treatment that protects the human body when it is most defenseless. (livescience.com)

Amount of radiation10

• The amount of radiation that a person's body absorbs is called the radiation dose. (cdc.gov)
• Acute Radiation Syndrome (ARS) is the medical term for the damage occurring to the body after exposure to large amount of radiation within a short period of time (24 hours). (epainassist.com)
• The amount of damage and the type of damage to the body depends on the dose and amount of radiation absorbed by the body. (epainassist.com)
• The amount of radiation absorbed in turn depends on the dose or the strength of the radiation and the distance between the source of radiation and the patient. (epainassist.com)
• The diagnostic imaging tests such as an x-ray only use small amount of radiation, which is usually below 0.1 Gy and that too the radiation is focused on small amount of tissue or organs. (epainassist.com)
• rad The U.S. unit used to measure absorbed radiation dose (the amount of radiation absorbed by an object or person). (epa.gov)
• The amount of radiation absorbed by the body - the absorbed dose - determines how sick you'll be. (pharmacypedia.org)
• The BfS says the maximum amount of radiation allowed from the DECT telephones by the International Commission for the Protection of Non-ionized Radiation is too high. (medindia.net)
• Base stations and the handset send out the same amount of radiation during a telephone call regardless of the user's distance from the base station. (medindia.net)
• Won't a tiny amount of radiation kill you? (dissidentvoice.org)

Injury7

• Depending on the mechanism of radiation, burns that appear immediately may be thermal rather than radiation injury, although complex mechanisms, not fully understood, are involved in radiation effects on the skin. (citizendium.org)
• However, results of treatment of ARS remain limited and in cases of severe radiation injury insufficient. (radioprotection.org)
• Primarily, external radiation is able to inflict acute health injury. (tidsskriftet.no)
• Most of the cases involved local injury , such as radiation burns or hematopoietic cancer . (bvsalud.org)
• When is the cell most susceptible to radiation injury? (studystack.com)
• We found that 22 of the 59 cases had more than one blood count within the first 72 hours after the radiation exposure, a prerequisite for the triage injury classification method to be tested. (cdc.gov)
• The risk of systemic infection is higher when the organism has a combined injury, such as a conventional blast, thermal burn, or radiation burn. (wikipedia.org)

Treatment of acute6

• Traditionally, the treatment of Acute Radiation Syndromes (ARS) includes supportive therapy, cytokine therapy, blood component transfusions and stem cell transplantation. (radioprotection.org)
• Treatment of acute radiation syndrome consists of supportive therapy with blood transfusions, antibiotics to combat infection. (epainassist.com)
• Treatment of acute radiation syndrome is generally supportive care . (mdwiki.org)
• Treatment of acute radiation syndrome is generally supportive with blood transfusions and antibiotics , with some more aggressive treatments, such as bone marrow transfusions, being required in extreme cases. (gutenberg.org)
• PSTI ), a leading developer of placenta-based cell therapy products, announced today the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome (ARS) at the American Society of Hematology's (ASH) 59th Annual Meeting to be held in Atlanta, Georgia, on December 9-12, 2017. (globenewswire.ca)
• To date, the only three drugs approved by the U.S. Food and Drug Administration for treatment of acute radiation syndrome are growth factors targeting granulocyte (Neupogen ® or Neulasta ® ) or granulocyte and macrophage (Leukine ® ) hematopoietic cell lineages. (bioone.org)

Clinical8

• Radiation Neurotoxin isolated from lymphatic system of irradiated animals (with a clinical picture of cerebral radiation syndrome) and injected to healthy animals in toxic doses 0.03 mg/kg, 0.5 mg/kg, 10.0 mg/kg, 15.0 mg/kg had initiated development of acute failure of blood circulation and breathing ventilation. (radioprotection.org)
• Her research has spanned drug discovery, preclinical development, manufacturing and clinical development in indications such as acute radiation syndrome , inflammation, infectious disease, cancer and cancer supportive care. (freethesaurus.com)
• Estimate a patient's absorbed radiation dose (i.e., level of radiation exposure) based on information from public health authorities, biodosimetry if available, or clinical findings such as time to onset of vomiting or lymphocyte depletion kinetics . (rxlist.com)
• Clinical trials which have been conducted both in the United States, with the National Institute of Health and at Hadassah-University Medical Center in Jerusalem, have shown a nearly 100 percent recovery rate in animals exposed to radiation. (yahoo.com)
• Yaky Yanay, President and Chief Operations Officer at Pluristem Therapeutics and co-chairman of Israel Advanced Technology Industries (IATI), said clinical trials have so far shown optimal results if the vial is injected within 48 hours of exposure to lethal radiation. (yahoo.com)
• In: Ricks RC, Berger ME, O'Hara FM (eds) The medical basis for radiation accident preparedness: the clinical care of victims. (springer.com)
• The initial focus of effort on the NIOSH ARS project, a component of Project 2.3, waS to add clinical information concerning the 59 accidentally radiation -exposed workers in the former Soviet Union during 1948 through 1958 to a similar number of accident cases collected in the Western world. (cdc.gov)
• In view of the rarity of the syndrome, all 59 cases were prepared for further study in Project 2.3 A selection was therefore made of 77 clinical and laboratory items that were of most significance and likely to be on record in most cases. (cdc.gov)

Mitigation3

• The company's proprietary platform of toll-like immune receptor activators has applications in radiation mitigation, oncology immunotherapy, and vaccines. (yahoo.com)
• Mice on flaxseed displayed improved survival rates and mitigation of radiation pneumonitis, with increased blood oxygenation levels, higher body weight, lower pro-inflammatory cytokine levels, and greatly reduced pulmonary inflammation and fibrosis. (medindia.net)
• Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding. (iu.edu)

Type of radiation3

• Absorbed and equivalent radiation doses can not be directly converted as the conversion depends on the type of radiation. (convert-me.com)
• Understanding the type of radiation received, the way a person is exposed (external vs. internal), and for how long a person is exposed are all important in estimating health effects. (epa.gov)
• They also try get more information about the exposure, such as what type of radiation it was, how far away you were from the source of the radiation, and how long you were exposed. (medlineplus.gov)

Illness caused1

• An acute illness caused by a dose greater than 50 rads of penetrating radiation to most or all of the body in a short time, usually a matter of minutes. (drugster.info)

Nausea1

• People who receive a single large dose of 1,000 millisieverts of radiation to the total body can expect to experience acute radiation syndrome, characterized by changes in blood count, nausea, vomiting and diarrhea. (go.com)

Radiological1

• It follows the format of the Syllabus in Radiation Biology prepared by the Radiological Society of North America (RSNA), and its content reflects the questions appearing in recent years in the written examination for diagnostic radiology residents given by the American Board of Radiology. (helsinki.fi)

Involving radiation exposure1

• The SNS developed recommendations to help health care professionals respond appropriately in the event of an attack involving radiation exposure. (annals.org)

Biological2

• Biological dosimetry is an essential tool for estimating radiation dose. (elsevier.com)
• The sievert is a unit of dosage that is used to evaluate the biological effects of radiation. (go.com)

Burns3

• Conventional trauma and burns resulting from a bomb blast are complicated by the poor wound healing caused by hematopoietic syndrome, increasing mortality. (wikipedia.org)
• Being exposed to a lot of radiation over a short period of time, such as from a radiation emergency , can cause skin burns . (medlineplus.gov)
• Two employees of a company licensed by the U.S. Atomic Energy Commission to encapsulate sources for radiographic cameras received radiation burns after being exposed to 192 Ir powder. (wikipedia.org)

Tissue4

• However, GM-CSF is not expressed in radiation injured tissue due to defervescence of the macrophages. (dovepress.com)
• Each syndrome requires that the tissue showing the syndrome itself be exposed. (mdwiki.org)
• Gamma radiation and x-rays are electromagnetic radiation (ie, photons) of very short wavelength that can penetrate deeply into tissue (many centimeters). (merckmanuals.com)
• Procedure planning is an important part of radiation therapy in order to achieve optimal tumor reduction without damaging too much healthy tissue. (medgadget.com)

Radioprotective1

• Antiradiation vaccine : immunoprophylaxis of acute radiation syndromes - radioprotective efficiency. (radioprotection.org)

Workers8

• There have been studies that kept track of large numbers of people who were exposed to radiation, including atomic bomb survivors and radiation industry workers. (epa.gov)
• Exposure prevention is clearly possible in radiation -exposed workers . (bvsalud.org)
• Another (interim) report carried out by the United Nation's scientific committee says that there was no association between the deaths of six workers at the plant during the accident and radiation exposure. (medicalnewstoday.com)
• Even though a number of workers had had radiation exposure to their skin, no detectable health effects were present. (medicalnewstoday.com)
• The main objective of the parent project, Joint Collaborative Committee for Radiation Effects Research (JCCRER) Project 2.3, is the development of a database of Mayak PA workers to use for such purposes as the verification of current dose-effect models for deterministic effects of acute exposure including the acute radiation syndrome or ARS. (cdc.gov)
• The most famous incident is the " Radium Girls " of Orange, New Jersey where a large number of workers got radiation poisoning. (wikipedia.org)
• News sources have said that the number of workers cycling through the damaged reactor has been increased from 50 to 100, and the Japanese Health Ministry raised the maximum radiation dose for the workers from 100 to 250 millisieverts (mSv). (livescience.com)
• There are stationary radiation detectors throughout the plant, as well as portable radiation detectors that can be carried around by workers. (livescience.com)

Cause acute1

• Low-dose exposure to radiation, such as occurring during imaging tests like x-ray, MRI scan or CT scan do not cause acute radiation syndrome. (epainassist.com)

Lethal2

• In order to maintain the macrophage's important role in host defense after radiation exposure, it is hypothesized that it is necessary to administer the drug exogenously in order to uphold the barrier against exogenous and endogenous infections and possibly prevent the potentially lethal systemic infection, which is the main cause of death in ARS. (dovepress.com)
• A suspension of synthetic genistein nanoparticles was previously shown to be an effective radioprotectant against H-ARS when administered prior to exposure to a lethal dose of total body radiation. (indigobiosciences.com)

Level of radiation4

• This level of radiation would be like getting the radiation from 18,000 chest x-rays distributed over your entire body in this short period. (epa.gov)
• We've been investigating the placenta for the last decade and we have discovered that the placenta cells have unique properties that can help the body to recover after exposure to high level of radiation,' Lukasiewicz Hagai said. (yahoo.com)
• It should be noted, however, that 250 mSv is not an unreasonable level of radiation . (livescience.com)
• That's important in cases such as what's happening in Japan , where people may not learn the level [of radiation] they have been exposed to until 24 to 48 hours later. (livescience.com)

20021

• Barabanova AV (2002) Acute radiation syndrome with cutaneous syndrome. (springer.com)

Effects18

• Neutron or proton radiation produces many of the health effects described herein at lower absorbed dose levels. (cdc.gov)
• The Biomedical Advanced Research and Development Authority (BARDA) exercised $6 million in additional contract options under its advanced research and development contract with Aeolus Pharmaceuticals for AEOL-10150, a broad-spectrum catalytic antioxidant specifically designed to neutralize reactive oxygen and nitrogen species, as a treatment for the pulmonary syndrome of acute radiation syndrome (Lung-ARS) and delayed effects of acute radiation exposure (DEARE). (genengnews.com)
• This syndrome is the collection of bodily effects resulting from exposure to large amounts of radiation. (annals.org)
• 5,000-10,000 millirem or 50-100 millisieverts) usually result in no harmful health effects, because radiation below these levels is a minor contributor to our overall cancer risk. (epa.gov)
• A detailed account of radiation, its mode of action, side effects and dosage in the treatment of cancer. (medindia.net)
• Flax used for weaving cloth, feeding people and animals, and even making paint could also protect healthy tissues and organs from the harmful effects of radiation, according to a new study. (medindia.net)
• The victims of the atomic bombings either died immediately due to the detonation or later as a result of the acute or delayed effects of ionising radiation . (bfs.de)
• The mean weighted colon dose (weighting: gamma colon dose + 10*neutron colon dose ) is used by the Radiation Effects Research Foundation (RERF) as a measure for the radiation exposure of the survivors. (bfs.de)
• What are the long-term effects of radiation exposure? (health.com)
• He reiterates throughout the show that radiation exposure-even at moderate or low levels-can have long-term effects on a person's health. (health.com)
• Mettler FA, Moseley RD (1985) Carcinogenesis of specific sites and direct effects of radiation. (springer.com)
• What are the health effects of radiation exposure? (medlineplus.gov)
• A fetus is most vulnerable to the effects of radiation. (medlineplus.gov)
• Experts agree that simple measures like creating a sealed containment in one's home and washing one's body and clothing has a direct impact on long-term and short-term effects of potential radiation exposure. (go.com)
• Her death, at age 67, in 1934 was from aplastic anemia due to massive exposure to radiation in her work, [2] much of which was carried out in a shed with no proper safety measures being taken, as the damaging effects of hard radiation were not generally understood at that time. (wikipedia.org)
• This would keep worker doses below the thresholds for health effects like acute radiation syndrome. (livescience.com)
• Heritable Effects of Radiation 12. (helsinki.fi)
• Effects of Radiation on the Embryo and Fetus 13. (helsinki.fi)

Lethality2

• Among other things, apoptosis is largely responsible for the lethality of high-dose radiation exposure. (yahoo.com)
• Subcutaneous wounding postirradiation reduces radiation lethality in mice. (iu.edu)

Development of acute1

• Radiation Toxins of Specific Radiation Deteminant group(neuro-toxic, neuro-vascular-toxic, entero-toxic, hemato-toxic) play an important role in development of Acute Radiation Syndromes and development of multi-organ involvement and multi-organ failure. (radioprotection.org)