A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.
Uncontrolled release of radioactive material from its containment. This either threatens to, or does, cause exposure to a radioactive hazard. Such an incident may occur accidentally or deliberately.
Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.
Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.
A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.
A characteristic symptom complex.
Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Warfare involving the use of NUCLEAR WEAPONS.
Organizations established by endowments with provision for future maintenance.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.

Expression of phospho-Elk-1 in rat gut after the whole body gamma irradiation. (1/35)

Gastrointestinal form is the second stage of acute radiation syndrome (ARS) with a threshold dose of 8 Gy in man. It represents an absolutely lethal clinical-pathological unit, necro-hemorrhagic enteritis and proctocolitis, with unknown causal therapy. Elk-1 is a protein acting as a transcription factor activating specified genes. The purpose of our study was to examine the expression of phospho-Elk-1 in irradiated jejunum and transversal colon of rats with radiation-induced enterocolitis and to assess the importance of this transcriptional factor as a biodosimetric marker of radiation-induced enteropathy. The laboratory rats were randomly divided into 21 groups, 10 animals per group, and irradiated with whole body gamma-irradiation of 1, 5, 10, 15, and 20 Gy. Samples of jejunum and transversal colon were taken 24, 48, 72, and 96 hours later, immunohisto-chemically stained, and the phospho-Elk-1 expression was examined using computer image analysis. A group of 10 sham-irradiated animals was used as control. Significantly increased expression of phospho-Elk-1 in rat jejunum has been found in all time intervals after irradiation by sublethal doses of 1 and 5 Gy, whereas after the irradiation by lethal doses, the expression of phospho-Elk-1 in rat jejunum varied considerably. Significantly increased expression of phospho-Elk-1 in transversal colon has also been found in the first days after irradiation by sublethal doses of 1 and 5 Gy. After irradiation by lethal doses, there was no uniform pattern of the changes in the expression of phospho-Elk-1 in rat transversal colon. The detection of phospho-Elk-1 might be considered as a suitable and very sensitive biodosimetric marker of radiation-induced injury of small and large intestine. According to our knowledge, this is the first study on the phospho-Elk-1 expression in irradiated jejunum and transversal colon in the rat.  (+info)

Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. (2/35)

Neurogenesis in the adult hippocampus, which occurs constitutively, is vulnerable to ionizing radiation. In the relatively low-dose exposure of acute radiation syndrome (ARS), the change in the adult hippocampal function is poorly understood. This study analyzed the changes in apoptotic cell death and neurogenesis in the DGs of hippocampi from adult ICR mice with single whole-body gamma-irradiation using the TUNEL method and immunohistochemical markers of neurogenesis, Ki-67 and doublecortin (DCX). In addition, the hippocampus-dependent learning and memory tasks after single whole-body gamma-irradiation were examined in order to evaluate the hippocampus-related behavioral dysfunction in the relatively low-dose exposure of ARS. The number of TUNEL-positive apoptotic nuclei in the dentate gyrus (DG) was increased 6-12 h after acute gamma-irradiation (a single dose of 0.5 to 4 Gy). In contrast, the number of Ki-67- and DCX-positive cells began to decrease significantly 6 h postirradiation, reaching its lowest level 24 h after irradiation. The level of Ki-67 and DCX immunoreactivity decreased in a dose-dependent manner within the range of irradiation applied (0-4 Gy). In passive avoidance and object recognition memory test, the mice trained 1 day after acute irradiation (2 Gy) showed significant memory deficits, compared with the sham controls. In conclusion, the pattern of the hippocampus-dependent memory dysfunction is consistent with the change in neurogenesis after acute irradiation. It is suggested that a relatively low dose of ARS in adult ICR mice is sufficiently detrimental to interrupt the functioning of the hippocampus, including learning and memory, possibly through the inhibition of neurogenesis.  (+info)

Dose estimation by chromosome aberration analysis and micronucleus assays in victims accidentally exposed to (60)Co radiation. (3/35)

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The radiation protection and therapy effects of mesenchymal stem cells in mice with acute radiation injury. (4/35)

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Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation. (5/35)

This study examined whether amifostine (WR-2721) could attenuate memory impairment and suppress hippocampal neurogenesis in adult mice with the relatively low-dose exposure of acute radiation syndrome (ARS). These were assessed using object recognition memory test, the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunohistochemical markers of neurogenesis [Ki-67 and doublecortin (DCX)]. Amifostine treatment (214 mg/kg, i.p.) prior to irradiation significantly attenuated the recognition memory defect in ARS, and markedly blocked the apoptotic death and decrease of Ki-67- and DCX-positive cells in ARS. Therefore, amifostine may attenuate recognition memory defect in a relatively low-dose exposure of ARS in adult mice, possibly by inhibiting a detrimental effect of irradiation on hippocampal neurogenesis.  (+info)

Radiation rescue: mesenchymal stromal cells protect from lethal irradiation. (6/35)

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Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation. (7/35)

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Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident. (8/35)

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Looking for online definition of acute radiation syndrome in the Medical Dictionary? acute radiation syndrome explanation free. What is acute radiation syndrome? Meaning of acute radiation syndrome medical term. What does acute radiation syndrome mean?
Synonyms for Acute radiation syndrome in Free Thesaurus. Antonyms for Acute radiation syndrome. 7 synonyms for syndrome: condition, complaint, illness, symptoms, disorder, ailment, affliction. What are synonyms for Acute radiation syndrome?
This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.
HAIFA, Israel, Dec. 07, 2017 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (NASDAQ:PSTI) (TASE:PSTI), a leading developer of placenta-based cell therapy products, announced today the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome (ARS) at the American Society of Hematologys (ASH) 59th Annual Meeting to be held in Atlanta, Georgia, on December 9-12, 2017.. The results of the study will be presented during Program Session 506: Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion, and Stromal Stem Cells. The poster, Intramuscular Administration of Placenta-Derived Stromal Cells Enhances Survival of Rhesus Macaque Monkeys Exposed to Total Body Irradiation, will describe data from a recently announced Phase II-equivalent study under the U.S. Food and Drug Administration (FDA) Animal Rule. The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. This ...
Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) - Pipeline Review, H1 2017, provides an overview of the Radiation Toxicity (Radiation Sic
Acute effects of ionizing radiation were first observed when Wilhelm Röntgen intentionally subjected his fingers to X-rays in 1895. He published his observations concerning the burns that developed that eventually healed, and misattributed them to ozone. Röntgen believed the free radical produced in air by X-rays from the ozone was the cause, but other free radicals produced within the body are now understood to be more important. D. Walsh first established the symptoms of radiation sickness in 1897. Ingestion of radioactive materials caused many radiation-induced cancers in the 1930s, but no one was exposed to high enough doses at high enough rates to bring on acute radiation syndrome. The Radium Girls were female factory workers who contracted radiation poisoning from painting watch dials with self-luminous paint at the United States Radium factory in Orange, New Jersey, around 1917. The atomic bombings of Hiroshima and Nagasaki resulted in high acute doses of radiation to a large number of ...
After irradiation with 2, 4, 7, or 12 Gy, changes in the bone marrow cells over time were examined through H&E staining and Ki-67 staining, a proliferation marker. In minipigs irradiated with 2 or 4 Gy, the myeloid hematopoietic cells disappeared drastically, starting at 30 minutes after irradiation; at the 17-hour point, only a minimal number of myeloid cells remained. On day 3 after irradiation, only some plasmacytoid cells and erythroblasts were observed; Ki-67 positive cells were hardly found (Figure 4A and B). For minipigs irradiated with 7 or 12 Gy, bone marrow tissues were obtained when they succumbed. In the histological analysis, we found that the bone marrow of these 2 minipigs was replaced with adipose cells, with a very small number of plasmacytoid myeloid cells. Moreover, few Ki-67 positive cells were found in the bone marrow (Figure 4C ...
Some may think that certain data are emphasized in this and other chapters in an attempt to minimize the dangers of exposure to radiation. This is not at all true. I am trying to put the dangers in perspective and eliminate the Pavlovian negative response to even the very mention of the subject. Table 8 shows the accepted syndrome from short-term exposures. Please note that this table is in rems (not millirems) and can be mentally converted to centisieverts (cSvs) of the same numerical value. Radiation can obviously be very dangerous. But so can an unreasonable fear of radiation ...
Online conversion from Nausea And Vomiting (Acute Radiation Syndrome) to Hourly Average Background Radiation (Radiation Dose Examples). Radiation Converter.
Online conversion from Death (Acute Radiation Syndrome) to Dental Radiology (Radiation Dose Examples). Radiation Converter.
Online conversion from Death (Acute Radiation Syndrome) to Sievert (Sv, Dose Equivalent Radiation). Radiation Converter.
Online conversion from Nausea And Vomiting (Acute Radiation Syndrome) to Millirem (Dose Equivalent Radiation). Radiation Converter.
Sixteen Lewis (RT1l) rats were exposed to sublethal dose (7Gy) of Cs-137 TBI. Irradiated rats were divided into 4 experimental groups (n=4 each) based on therapeutic approach: Group 1 - no intervention; Group 2 - normal saline injection; Group 3 - allogeneic bone marrow transplantation (BMT) [ACI (RT1a)]; and Group 4 - DRCC transplantation [ACI/LEW (RT1a/RT1l]. Saline as well as cellular therapeutics were delivered into the femoral bone at 6 hours following TBI. DRCC were created by ex-vivo fusion of bone marrow cells derived from fully MHC mismatched LEW (RT1l) and ACI (RT1a) donors. Briefly, donor and recipient cells were isolated, separately stained with the PKH26 and PKH67 fluorescent dyes, fused with polyethylene glycol (PEG) and sorted by flow cytometry. Cells presenting double staining were transplanted in a dose 10-12 x 106. All animals received supportive treatment with prophylactic antibiotics, fluids, and softened food during 90-days follow-up. Blood samples were evaluated using ...
Disaster Med Public Health Prep. 2011 Oct;5(3):202-12. doi: 10.1001/dmp.2011.68. Epub 2011 Oct 10. Research Support, Non-U.S. Govt; Review
Exposure to high doses of ionizing radiation in the event of therapeutic, accidental or intentional incident such as nuclear/radiological warfare can lead to debilitating injuries to multiple organs resulting in death within days depending on the amount of radiation dose and the quality of radiation. Unfortunately, there is not a single FDA-licensed drug approved against acute radiation injury.. Radiation damage to multiple organs often described as multiple organ dysfunction syndrome (MODS) or acute radiation syndrome (ARS) results from rapid depletion of radiosensitive cells, these cells are usually the stem or progenitor cells with high proliferative capacity; naturally, bone marrow stem cells (BMSC), and intestinal stem cells (ISC), which are extremely critical in maintaining a pool of peripheral blood cells and in maintaining villi for the absorption of nutrients are highly sensitive to radiation. One of the most efficient ways of rescuing MODS is to administer fresh cells that can repair, ...
Date: August 22, 2013. Company: BCN Biosciences, headquartered in Pasadena, Calif.. Cooperative agreement amount: BARDA will contribute $4 million over two years About the cooperative agreement: Through this cooperative agreement, BARDA will fund and collaborate on proof-of-concept studies by BCN Biosciences to determine how well a novel small molecule called Yel002, created by the company, protects DNA from damage after the bodys cells are exposed to damaging levels of radiation. This approach may increase the likelihood that cells in the gastrointestinal injury will survive exposure to acute radiation.. The GI tract is particularly sensitive to radiation but currently there is no treatment or preventive measure for this type of ionizing (damaging) radiation injury.. Acute Radiation Syndrome, also known as ARS, is a serious illness that occurs when all or most of the body receives a high dose of radiation, such as after the detonation of a nuclear device. ARS involves injuries to the bodys ...
Acute radiation syndrome ( ARS ), also known as radiation poisoning , radiation sickness or radiation toxicity , is a collection of health effects which present within 24 hours of exposure to high...
Purpose: Discovery of agents that protect or mitigate normal tissue from radiation injury during radiotherapy, accidents, or terrorist attacks is of importance. Specifically, bone marrow insufficiency, with possible infection due to immunosuppression, can occur after total body irradiation (TBI) or regional irradiation and is a major component of the acute radiation syndrome. The purpose of this study was to identify novel radioprotectors and mitigators of the hematopoietic system.. Experimental Design: High-throughput screening of small-molecule libraries was done using viability of a murine lymphocyte line as a readout with further validation in human lymphoblastoid cells. The selected compounds were then tested for their ability to counter TBI lethality in mice.. Results: All of two major classes of antibiotics, tetracyclines and fluoroquinolones, which share a common planar ring moiety, were radioprotective. Furthermore, tetracycline protected murine hematopoietic stem/progenitor cell ...
Exposure to a moderate to high dose of ionizing radiation (IR) not only causes acute radiation syndrome but also induces long-term (LT) bone marrow (BM) injury. The latter effect of IR is primarily attributed to the induction of hematopoietic stem cell (HSC) senescence. Granulocyte colony-stimulating factor (G-CSF) is the only treatment recommended to be given to radiation victims soon after IR. However, clinical studies have shown that G-CSF used to treat the leukopenia induced by radiotherapy or chemotherapy in patients can cause sustained low white blood cell counts in peripheral blood. It has been suggested that this adverse effect is caused by HSC and hematopoietic progenitor cell (HPC) proliferation and differentiation stimulated by G-CSF, which impairs HSC self-renewal and may exhaust the BM capacity to exacerbate IR-induced LT-BM injury. C57BL/6 mice were exposed to 4 Gy γ-rays of total body irradiation (TBI) at a dose-rate of 1.08 Gy per minute, and the mice were treated with G-CSF (1 μg/each
Mass casualty scenarios of radiation exposure require high throughput biological dosimetry techniques for population triage, in order to rapidly identify individuals, who require clinical treatment. Accurate dose estimates can be made by biological dosimetry, to predict the acute radiation syndrome (ARS) within days after a radiation accident or a malicious act involving radiation. Timely information on dose is important for the medical management of acutely irradiated persons [1]. The aim of the study was to evaluate the usefulness of the micronuclei (MNi) scoring procedure in an experimental mode, where 500 binucleated cells were analyzed in different exposure dose ranges. Whole-body exposure was simulated in an in vitro experiment by irradiating whole blood collected from one healthy donor with 60 MeV protons and 250 keV X-rays, in the dose range of 0.3-4.0 Gy. For achieving meaningful results, sample scoring was performed by three independent persons, who followed guidelines described in ...
Cancer is a stochastic effect of radiation, meaning that the probability of occurrence increases with effective radiation dose, but the severity of the cancer is independent of dose. The speed at which cancer advances, the prognosis, the degree of pain, and every other feature of the disease are not functions of the radiation dose to which the person is exposed. This contrasts with the deterministic effects of acute radiation syndrome which increase in severity with dose above a threshold. Cancer starts with a single cell whose operation is disrupted. Normal cell operation is controlled by the chemical structure of DNA molecules, also called chromosomes. When radiation deposits enough energy in organic tissue to cause ionization, this tends to break molecular bonds, and thus alter the molecular structure of the irradiated molecules. Less energetic radiation, such as visible light, only causes excitation, not ionization, which is usually dissipated as heat with relatively little chemical damage. ...
SIGNS AND SYMPTOMS/ /ACUTE RADIATION SYNDROME/ Fifty persons involved in the cesium-137 accident in Goiania showed symptoms of whole-body and local acute irradiation and also external or internal contamination mainly due to ingestion or absorption of cesium-137. Fourteen of the 50 developed severe bone marrow depression characterized by neutropenia and thrombocytopenia. Eight of these 14 received GM-CSF intravenously. None were submitted to bone marrow transplantation. Four of the 14 died due to hemorrhage and infection. For those with significant internal contamination evaluated by in-vitro and in-vivo assays, Prussian Blue was administered with doses ranging from 1.5 to 10 g/day. Besides Prussian Blue, other measures were taken to increase decorporation of cesium-137, including administration of diuretics, water overload, and ergometric exercises. From 50 to 100 persons are being followed in a medical protocol ...
BackgroundIonizing radiation induces lipid peroxidation and forms reactive oxygen species (ROS) within the cell. Due to their highly reactive state, ROS have short diffusion distances and quickly transfer unbalanced electrons to neighboring molecules. This transfer cycle continues until it finally culminates in the generation of reactive alkenals such as 4-hydroxynonenal (4HNE). Under normal conditions, intracellular 4HNE levels are controlled by conjugation to glutathione and are actively transported from the cell; RLIP76 protein has been determined to be the major transport protein involved in the efflux of 4HNE-conjugates. Radiation induces significant oxidative stress, and the increased levels of 4HNE conjugates overwhelm transport capacity. When this occurs, further conjugation is inhibited and free 4HNE levels rise, triggering apoptosis. It was hypothesized that adding exogenous RLIP76 protein would reduce 4HNE levels and correspondingly increase the recovery from acute radiation syndrome (ARS) or
HAIFA, Israel, July 18, 2013-- Pluristem Therapeutics Inc., a leading developer of placenta-based cell therapies, announced today that the U.S. National Institute of Allergy and Infectious Diseases, part of the U.S. National Institutes of Health, has recommended to Pluristem that NIAID expand the scope of its ongoing animal research using PLX-RAD cells for the treatment of acute radiation syndrome.
Appropriate models are essential for making the transition from scientific discoveries to meaningful applications of the knowledge for human use. Acute as well as delayed effects of ionising radiation to the biological systems develop hierarchically starting from damage to the vital macromolecules up to the disturbances caused at the whole organism level. In vitro models like bacteria, yeast, various mammalian cells cultured as monolayers (2-D) and spheroids (3-D) as well as cells with specific genetic alterations have provided insight into the complex relationships between damage induction and various signal transduction pathways, allowing identification of molecular and sub-cellular targets vital to the fate of irradiated cells. On the other hand, in vivo models (multicellular whole organisms), ranging from simple worms to non-human primates, have been gainfully employed to evaluate efficacy as well as toxicity of potential countermeasure agents (molecules, combinations and formulated ...
The study assessed the safety and efficacy of Pluristem Therapeutics PLX-R18 following intramuscular injection into irradiated and non-irradiated NHPs.
Growing concern over terrorism and the possible use of weapons of mass destruction, including nuclear and radiologic devices, has drawn attention to the need to prepare for potential, large-scale radiation incidents.
Degenerative changes occur as soon as 30 minutes after exposure of 500-1000 rad. Initial effects are: impaired secretion of necessary fluids: cell breakdown results in failure of food and water absorption leading to infection and dehydration from diarrhea ...
Radiation doses exceeding a threshold of about 500 millisieverts (mSv) can cause tissue reactions in the human body, also called deterministic effects. They are the result of a massive cell killing and the subsequent loss of function of the affected organs or tissues.
Radiation doses exceeding a threshold of about 500 millisieverts (mSv) can cause tissue reactions in the human body, also called deterministic effects. They are the result of a massive cell killing and the subsequent loss of function of the affected organs or tissues. Particularly ...
Sorption Detoxification as an Addition to Conventional Therapy of Acute Radiation Sickness and Iatrogenic Leukopenia. By Oksana O. Shevchuk, Elisaveta A. Snezhkova, Anatoliy G. Bilous, Veronika V. Sarnatskaya, Kvitoslava I. Badakhivska, Larysa A. Sakhno, Vasyl F. Chekhun and Volodymyr G. Nikolaev. Leukopenia is an essential part of the clinical course of acute radiation sickness and is a side effect of anti-cancer treatment. In both situations, the main factors which determine the survival are the degree of bone marrow suppression and gastrointestinal tract damage due to the presence of a large pool of fast-dividing cells. Leuko- and neutropenia are main limiting factors which may contribute to chemotherapy failure. Hematopoietic cytokines the part of conventional therapy in this field, but their effects require boosting. That is why the use of means and methods of adsorption therapy is considered promising. Sorption therapy creates a basis for sorption detoxification, a doctrine of curative ...
NSWP is publishing the results of a global consultation exercise, carried out with our members in every region, and now written up into all the five languages of NSWP, for December 17th, International Day to End Violence Against Sex Workers.
The rationale for the use of the Animal Rule must be supported by proof-of-concept animal studies designed to ensure animal welfare, demonstrate relevance of the animal model (species susceptibility to the toxic agent and toxic response similar to humans), define the endpoint used to assess efficacy and predict human clinical benefit (eg, relief or prevention of adverse effects), ensure data quality and integrity in a contained environment, and be conducted under Good Laboratory Practice (GLP) guidelines. When efficacy is demonstrated in a single study, conducted in a sufficiently well‑characterized animal model, it may be necessary to repeat the study, preferably in another laboratory for confirmation. The investigational drug/biologic used in the adequate and well-controlled animal efficacy studies and in the animal pharmacokinetics and/or pharmacodynamics studies used to select a dose and dosing regimen in humans, ideally should be manufactured under current GMP regulations and be as close ...
Read Transcript, Download (.mov, 14MB). This final segment introduces the Clinical Decision Guide, a critical benchmark that can be used by clinicians in addition to other factors to help determine if medical countermeasures are indicated for a particular patient.. The Clinical Decision Guide (CDG) is an operational quantity that is specific to a type of radionuclide and a route of exposure (e.g. cesium-137 inhalational exposure). The CDG of children (0-18 yrs) and pregnant women is 20% that of adults.. For most radionuclides, the CDG is defined by the amount (activity) of radioactive material delivering an effective dose of 0.25 Sieverts (Sv) after incorporation into the body. This dose represents about a 1.3% lifetime risk of fatal cancer attributable to the exposure. Radiation measurements from a urine sample above a CDG value suggest the potential for a higher attributable lifetime fatal cancer risk and may help clinicians decide whether or not to start countermeasure treatment.. The CDG can ...
The National Institutes of Health recently posted a solicitation for the development of medical countermeasures to enhance platelet regeneration and survival following radiation exposure from a nuclear or radiological incident.
NAM and EATG, Europes community group for people with HIV, have launched a consensus statement, for endorsement by the HIV community, on using HIV treatment to prevent the transmission of HIV. ART drugs if taken as prescribed can effectively render people non-infectious. This treatment has not already ended the HIV epidemic for several reasons including lack of access to drugs, no global consensus on who should get them,.... ...
Circulation and muscle tone.. Many skin conditions are a result of a poor moisture barrier. An essential focus is to support restoration of the skin barrier. Working with advanced microcurrent/LED technology that is teamed with professional products and treatment, the skin is gently encouraged the skin to become healthier. There are newer paradigm shifts when it comes to skin correction. When the underlying skin structures remain strong and healthy, it manifests in the skins appearance. We believe that there is a place for all technology and newer chemical procedures. The global consensus from scientists, and many medical and skin care professionals is to protect the integrity of the skin during all procedures. Being too aggressive with treatments may actually age the skin faster. Your program is based on your age, skin condition and history. It also may require patience and time.. ...
The Addressing Lupus Pillars for Health Advancement (ALPHA) project is a unique global consensus initiative that seeks to identify and prioritize the fundamental barriers or knowledge gaps that will allow providers, researchers and scientists to improve diagnosis, treatment and systems of care for people with lupus.
Aim 2: Perform preliminary countermeasure evaluation using radioprotective/chemopreventive agents that target common pathways of radiation induced injury (e.g. inflammation).. ...
The premier source of breaking business news for the government contracting industry, GovCon Wire provides informative, to-the-point stories of the most significant contract awards, top-level executive moves, M&A activities and financial results of the sectors most notable players.. GovCon Wire is always on top of the most recent contracting sector activity and is updated in real time as the news breaks. ...
Illnesses collectively called acute radiation syndrome occur within a few hours to months after exposure to high-dose radiation (from approximately 1-2 Gy to 10 Gy). The principal signs and symptoms include vomiting within a few hours, followed within days to weeks by diarrhea, reduced blood cell counts, bleeding, hair loss (epilation), and temporary male sterility. Diarrhea results from damage to cells lining the intestines, reduction in blood cells from death of hematopoietic stem cells in bone marrow, and bleeding from declining blood platelets generated from such stem cells. Hair is lost due to damage to hair-root cells. Hairs do not fall out but rather become thinner and eventually break off. Sterility occurs in men from damage to sperm-generating stem cells ...
HealthDay News) -- Once astronauts leave the Earths protective magnetic field, their cancer risk would soar while traveling to Mars, new research indicates.. Scientists said radiation exposure during a long-term deep-space mission would not only affect already damaged cells but also healthy ones nearby, doubling cancer risk.. Cosmic rays cause significant cell damage due from exposure to radiation, protons and heavy ions, the authors explained. Previous research has shown the health risks of deep space travel include cancer, cataracts, acute radiation syndromes, and problems with circulation and the central nervous system.. Typical risk models, including those used by NASA, assume radiation cancers are caused by DNA damage and mutations. These models, however, are based on much shorter times than a Mars mission would require, researchers noted.. Exploring Mars will require missions of 900 days or longer and includes more than one year in deep space where exposures to all energies of galactic ...
Soligenix, Inc., a Princeton, N.J.-based biopharmaceutical company, announced on Sunday that the U.S. Food and Drug Administration reviewed and approved its investigational new drug application for its gastrointestinal acute radiation syndrome drug.
Purpose: Studies of the association between ataxia telangiectasia-mutated (ATM) gene polymorphisms and acute radiation injuries are often small in sample size, and the results are inconsistent. We conducted the first meta-analysis to provide a systematic review of published findings. Methods and Materials: Publications were identified by searching PubMed up to April 25, 2014. Primary meta-analysis was performed for all acute radiation injuries, and subgroup meta-analyses were based on clinical endpoint. The influence of sample size and radiation injury incidence on genetic effects was estimated in sensitivity analyses. Power calculations were also conducted. Results: The meta-analysis was conducted on the ATM polymorphism rs1801516, including 5 studies with 1588 participants. For all studies, the cut-off for differentiating cases from controls was grade 2 acute radiation injuries. The primary meta-analysis showed a significant association with overall acute radiation injuries (allelic model: ...
The purpose of the present study was twofold: (1) to determine if X-irradiation can be considered a direct stress agent, and if so, to what extent it differs from other stressors; and (2) to further elucidate the role of the adrenal cortex in the radiation syndrome by determining the more immediate responses of this system to X-irradiation.
56 representatives of 34 global organisations have come together to reach consensus on the management of endometriosis, published in Human Reproduction.
While the concept of brain death is widely accepted, no universal criteria exist for its determination. This study compared guidelines from 80 countries finding that all standards specified exclusion of confounders, irreversible coma, absent motor response, and lack of brain-stem reflexes (see Wijdicks, The Diagnosis of Brain Death for more information). The majority of countries had medical practice standards (88%), legal standards (69%), utilized some form of apnea testing (59%), and required more than one physicians declaration (50%). Specifics varied widely on the qualifications of the physician, methods of apnea testing, and observation time before pronouncement of death. Regional differences were also noted, such as mandatory laboratory tests in Europe and Asia. Within the United States, brain death determination has been left to each state to decide (44 states and the District of Columbia have guidelines) whereas most African countries do not. Even if guidelines are not standardized, ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The threat of bioterrorism, long ignored and denied, has heightened over the past few years. Recent events in Iraq, Japan, and Russia cast an ominous shadow. Two candidate agents are of special concern: smallpox and anthrax. The magnitude of the problems and the gravity of the scenarios associated with release of these organisms have been vividly portrayed by two epidemics of smallpox in Europe during the 1970s and by an accidental release of aerosolized anthrax from a Russian bioweapons facility in 1979. Efforts in the United States to deal with possible incidents involving bioweapons in the civilian sector have only recently begun and have made only limited progress. Only with substantial additional resources at the federal, state, and local levels can a credible and meaningful response be mounted. For longer-term solutions, the medical community must educate both the public and policy makers about bioterrorism and build a global consensus condemning its use.
We are pleased to announce that our side event safety for the multi-transfused patients has been confirmed to take place on Friday 26 May 2017 at the 70th World Health Assembly. Linked to WHA70 agenda item of Principles for global consensus on the donation and management of ...
There is growing global consensus that the Information and communication technologies (ICTs), and particularly Internet are providing a new framework and huge opportunities for economic, political and social development. The World Summit for Social Development (WSSD, Copenhagen, 1995) recognized that the new information technologies and new approaches to access to and use of technologies by people living in poverty can help in fulfilling social development goals; and therefore recognize the need to facilitate access to such technologies. WSSD emphasized that promoting access for all to education, information, technology and know-how is an essential means for enhancing communication and participation in civil, political, economic, social and cultural life, and for ensuring respect for civil, political, economic, social and cultural rights. The World Summit on the Information Society (WSIS), Geneva 2003 - Tunis 2005, the Copenhagen Declaration and Tunis Commitment all recognized that ICTs is a key to
1. Promote safeguarding Remote learning creates new health and safety risks for children.. Online engagement by minors can lead to different forms of abuse. Some children and young people unable to attend school will be at a greater risk of harm at home. Governments have a fundamental responsibility to mitigate these risks and promote the importance of different forms of safeguarding.. 2. Make teaching engagement with vulnerable and disadvantaged students the top priority. The evidence relating to distance learning identifies student motivation, engagement and self-regulation as the single biggest challenge facing the remote teacher. This challenge is exacerbated in several ways by disadvantage. Insights from this Evidence Review are consistent with the global consensus that policymakers must make learning continuity with disadvantaged and vulnerable students the top priority during the period of school closure. At a local level, teachers should use all available means to keep in touch with ...
The expanded Center for Innovation in Advanced Development and Manufacturing (CIADM) in Baltimore helps the Nations pandemic preparedness.
The National Institute of Allergy and Infectious Diseases (NIAID), an institute within the NIH, is hoping to stave off the rise of the mutant zombies in th
CLT-008 is developed by the U.S. Food and Drug Administration Animal Rule for ARS. This approval pathway is available when human efficacy studies are neither ethical nor feasible and requires […]. ...
TOWNSEND: Well, the FDA Advisory Committee meets next week in this public hearing. Chimerix will be at it. If Chimerix can get their drug together, they can compete for it. They will look at the animal rule and the testing thats been -- thats gone on. And by the way, we talk about $433 million contract. If you look at the contract, you will see there are a number of milestones that the Siga as a company and the drug, SD-246, must meet in order to get payments along the way. This is not a guaranteed -- $433 million contract ...
A new $17 million research center dedicated to identifying medical countermeasures for neurotoxic chemicals that cause seizures in humans has been established by the U.S. National Institutes of Health at the University of California, Davis.
Acute Radiation Syndrome. Bradycardia[edit]. Main articles: Bradycardia and Athletic heart syndrome ... "Influence of heart rate on mortality after acute myocardial infarction". The American Journal of Cardiology. 65 (9): 547-53. ...
Filgrastim ('Neupogen') a hematopoietic countermeasure of acute radiation syndrome (ARS). Pegfilgrastim ('Neulasta') longer ... "Radiation Protection by a New Chemical Entity, Ex-Rad: Efficacy and Mechanisms". Radiation Research. 171 (2): 173-9. doi: ... This newly developed compound is said to be a potent radiation protection agent.[citation needed] Chemically, it is the sodium ... Onconova suggests that Ex-Rad protects cells exposed to radiation against DNA damage, and that the drug's mechanism of action ...
A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations. „Blood". 95 (12), s. 4011-3 ... acute myeloid leukemia lub acute myelogenous leukemia, AML lub acute non-lymphoblastic leukemia, ANLL) - grupa chorób ... Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias. „Semin Hematol". 39 (2), s. 128-33, Apr ... Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's ...
In March 2018 the label was extended to use as a countermeasure for acute radiation syndrome. "US Sargramostim label" (PDF). ... FDA approves Leukine for Acute Radiation Syndrome. Retrieved 29 March 2018.. ... It is also used to treat neutropenia induced by chemotherapy during the treatment of acute myeloid leukemia. It also used as a ... Schmeck HM (1987-11-02). "Radiation Team Sent to Brazil Saves Two With a New Drug". New York Times. Retrieved 2012-06-20. " ...
Young also suffered from acute radiation syndrome, but recovered. By 28 January 1948 Graves, Kline and Perlman sought ... and they are not considered as relevant to acute radiation syndrome as absorbed doses. Recent documents have made various ... He quickly collapsed with acute radiation poisoning and died 25 days later in the Los Alamos base hospital. After the war, ... Graves, who was standing the closest to Slotin, also developed acute radiation sickness and was hospitalized for several weeks ...
The crew suffered acute radiation syndrome (ARS) for a number of weeks after the Bravo test in March. During their ARS ... were diagnosed with acute radiation syndrome. The US did not respond to Nishiwaki's letter or to letters from other Japanese ... Radiation sickness symptoms appeared later that day. Due to this, the fishermen called the white ash shi no hai (死の灰, death ash ... High levels of radiation were found in the men's hair and nails, and so the hospital was forced to cut off the rest of their ...
Despite this, there were no deaths caused by acute radiation syndrome. Given the uncertain health effects of low-dose radiation ... No radiation-related deaths or acute diseases have been observed among the workers and general public exposed to radiation from ... Now radiation in Japan is as bad as radiation level is raised to 7 for only the second time in history' Daily Mail 12 April ... among them that this figure was based on an assumption of acute deaths from low radiation doses. There is no known mechanism ...
Despite this, there were no deaths caused by acute radiation syndrome. Given the uncertain health effects of low-dose radiation ... No radiation-related deaths or acute diseases have been observed among the workers and general public exposed to radiation from ... among them that this figure was based on an assumption of acute deaths from low radiation doses. There is no known mechanism ... and about 4 people out of 10 can be expected to develop cancer without exposure to radiation. Further, the radiation exposure ...
Died 25 days after the accident of acute radiation syndrome, haematopoietic focus [10]. ... died 9 days after the accident of acute radiation syndrome, gastrointestinal focus [11]. ... He quickly moved the brick off the assembly, but received a fatal dose of radiation. He died 25 days later from acute radiation ... "Acute Radiation Sickness". Tripod. Retrieved August 12, 2015.. *^ a b "A Review of Criticality Accidents" (PDF). Los Alamos ...
Many of them soon began to show symptoms of acute radiation syndrome. They returned to the islands three years later but were ... that the crew members were infected with hepatitis C through blood transfusions during part of their acute radiation syndrome ... but they all soon became ill with the effects of acute radiation sickness. One fisherman died about six months later while ... An 11-year-old boy who was born on Bikini in 1971 died from cancer that was linked to radiation exposure that he received on ...
List of books about nuclear issues Nuclear or Not? Environmental impact of nuclear power Acute Radiation Syndrome Flowers, Sir ... The focus of the first half of the chapter is designed to provide basic information about atoms and radiation to aid in later ... It begins by accepting that the hazards of ionizing radiation are well appreciated by anyone who works in the field and that ... The ionizing particles are alpha particles (a type of ionizing radiation ejected by the nuclei of some unstable atoms that are ...
He became the first known victim of lethal polonium 210-induced acute radiation syndrome. The events leading up to this are a ... becoming the first known victim of lethal Polonium 210-induced acute radiation syndrome. "CPS names second suspect in Alexander ... Guinness World Records: First murder by radiation: On 23 November 2006, Lieutenant Colonel Alexander Litvinenko, a retired ... Retrieved 1 December 2006.[dead link] Hall, Ben (27 November 2006). "Radiation traces found in Berezovsky office". Financial ...
During her work, she got sick with acute radiation syndrome, which lead to her death. Maria Orbeli was buried at the ...
Acute radiation syndrome, by acute whole-body radiation Radiation burns, from radiation to a particular body surface Radiation- ... High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled ... a potential side effect from radiation treatment against hyperthyroidism Chronic radiation syndrome, from long-term radiation. ... Eben Byers, a famous American socialite, died of multiple cancers (but not acute radiation syndrome) in 1932 after consuming ...
Acute radiation syndrome is a result of irreversible bone marrow damage from high-energy radiation exposure. Due to the ... they provide almost no protection from externally penetrating gamma radiation, which is the cause of acute radiation syndrome ... attenuation to only the most radio-sensitive organs and tissues in efforts to defer the onset of acute radiation syndrome, the ... The detonation of a "dirty bomb" would not cause a nuclear explosion, nor would it release enough radiation to kill or injure a ...
"Acute Radiation Syndrome: A Fact Sheet for Physicians". Centers for Disease Control and Prevention. 4 April 2018. Retrieved 7 ... Experiments in radiation biology have found that as the absorbed dose of radiation increases, the number of cells which survive ... Hyperfractionated radiation therapy is given over the same period of time (days or weeks) as standard radiation therapy. ... Hyperfractionated radiation therapy is given over the same period of time (days or weeks) as standard radiation therapy. ...
The thieves could have received a fatal dose of radiation. Acute radiation syndrome Nuclear and radiation accidents and ... Ten of the adults developed acute radiation syndrome. One exposed 60Co source was retrieved, but the source from the other ... all three died of radiation injury. February 1, 2000 - Samut Prakan radiation accident: The radiation source of an expired ... After 38 days radiation exposure was identified by medical personnel. The grandmother died of radiation injuries, and six ...
I don't understand why it happened." Akimov eventually succumbed to acute radiation syndrome two weeks after the disaster at ... Unknown to Akimov, he was exposed during his work to a lethal dose of 15 Gy of radiation.[page needed] At some point he gave ...
Intake of very large amounts of radioactive material can cause acute radiation syndrome (ARS) in rare instances. Examples ... In summary, not all radiation is harmful. The radiation can be absorbed through multiple pathways, varying due to the ... The radiation risk proposed by the International Commission on Radiological Protection (ICRP) predicts that an effective dose ... The most harmful way to absorb radiation is that of absorption because it is almost impossible to control how much will enter ...
Members of the crew suffered from acute radiation syndrome, with Kuboyama Aikichi dying of a related infection six months later ... When the tuna fishermen returned home, they exhibited symptoms of what would later be called acute radiation syndrome. Geiger ... Their catch of tuna and shark was also found to be contaminated with radiation, resulting in two tons of tuna buried at Tsukiji ... Oishi believed that his exposure to radiation caused this tragedy as well. In the mid-1990s, Oishi began to speak publicly at ...
He died three weeks later, becoming the first confirmed victim of lethal polonium-210-induced acute radiation syndrome. ... Unlike most common radiation sources, polonium-210 emits very little gamma radiation (the low intensity gamma ray at an energy ... Both gamma rays and alpha particles are classified as ionizing radiation which can cause radiation damage. An alpha-emitting ... "Radiation on airliners may be from poisoned spy". CNN. 29 November 2006. Archived from the original on 29 November 2006. ...
... not acute radiation syndrome.[4][7] He is buried in Allegheny Cemetery in Pittsburgh, Pennsylvania, in a lead-lined coffin.[5] ... His death on March 31, 1932, was attributed to "radiation poisoning" using the terminology of the time, but it was due to ... He earned notoriety in the early 1930s when he died from multiple radiation-induced cancers after consuming a popular patent ... "A Little Poison Can Be Good For You The received wisdom about toxins and radiation may be all wet". Fortune. Retrieved June 22 ...
134 station staff and firemen were hospitalized with acute radiation syndrome due to absorbing high doses of ionizing radiation ... The eventual medical report states that 28 people died from acute radiation syndrome over the following days to months. In the ... People with symptoms of acute radiation syndrome: 134 (237 were hospitalized), 28 died within 3 months, 14 died within the ... combining the deaths of approximately 50 emergency workers who died soon after the accident from acute radiation syndrome, 15 ...
In November 2006, Litvinenko died in London of acute radiation syndrome, three weeks after being poisoned with polonium-210. ( ...
In contrast, deterministic health effects are radiation-induced effects such as acute radiation syndrome, which are caused by ... In very high dose radiation therapy, it was known at the time that radiation can cause a physiological increase in the rate of ... Radiation Risk in Perspective PS010-4 [1] "Health Effects of Low-Level Radiation" (PDF). Position Statement #41. The American ... In a 2009 study cancer rates among UK radiation workers were found to increase with higher recorded occupational radiation ...
... and acute radiation syndrome. On Earth, we are protected by a magnetic field and our atmosphere, but asteroids lack this ... In space, cosmic rays and solar flares create a lethal radiation environment. Cosmic radiation has the potential to increase ... Cosmic radiation has the ability to impact the brain, and has been studied extensively on rats and mice. These studies show the ... One possibility for defense against this radiation is living inside of an asteroid. It is estimated that humans would be ...
Thurlow described the acute radiation syndrome that she and many others were victim of months and years after the bombing. She ... Her father died due to radiations in 1954, the same year that she went to study abroad and the year of the dropping of the H ... and the suffering from the atomic bomb casualty commission whose only purpose was to study the technical effects of radiations ...
National Institutes of Health is currently evaluating Pluristem's PLX-R18 cells as a treatment for acute radiation syndrome. ... "Pluristem, NIH to study stem cells to treat radiation syndrome". 26 July 2012 - via www.reuters.com. "Pluristem's post nuclear ... were initially developed with Professor Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome ... "Mitigation of Lethal Radiation Syndrome in Mice by Intramuscular Injection of 3D Cultured Adherent Human Placental Stromal ...
... and development of products with the potential to treat cancer and protect against death following acute radiation syndrome. ... acute radiation exposure drug, Entolimod. Genome Protection Inc. subsequently received a $10.5 million (US) investment from ... It is being developed both as a radiation countermeasure and as a cancer treatment. Entolimod is being developed and tested in ... Entolimod acts through activation of Toll-like Receptor 5 to mobilize antitumor immune response and reduce radiation effects on ...
... or in acute radiation syndrome (though deuterium is not radioactive), and is due to deuterium's action in generally inhibiting ... Heavy water radiation contamination confusion[edit]. Although many people associate heavy water primarily with its use in ... SNO detects the Cherenkov radiation in the water from high-energy electrons produced from electron-type neutrinos as they ... but rather radiation poisoning from other isotopes in the heavy water. Some news services were not careful to distinguish these ...
Acute respiratory distress syndrome (ARDS), alveolar hemorrhage, and allergic reactions (usually expressed in first 30 minutes ... p. 96, "Radiation doses were intense, being estimated at 205, 320, 410, 415, 422, and 433 rem. Of the six persons present, one ... Acute graft-versus-host disease typically occurs in the first 3 months after transplantation and may involve the skin, ... However, it is less effective in rapidly growing acute leukemias.[38] If cancer relapses after HSCT, another transplant can be ...
Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation, Board on Radiation Effects Research, U.S. ... Spinal manipulation may be cost-effective for sub-acute or chronic low back pain but the results for acute low back pain were ... "Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome". Cochrane Database of Systematic Reviews (1 ... There is moderate quality evidence to support the use of SM for the treatment of acute lumbar radiculopathy[101] and acute ...
General syndromes. *Nephritis. *Nephrosis. *Renal failure *Acute renal failure. *Chronic kidney disease ... Patients are referred to nephrology specialists after a urinalysis, for various reasons, such as acute kidney failure, chronic ...
假性肠梗阻(英语:Intestinal pseudoobstruction) / 奥格尔维综合征(英语:Ogilvie syndrome) ... 急性肝功能衰竭(英语:Acute liver failure) ... 放射性直肠炎(英语:Radiation proctitis). *痉挛性肛门直肠痛(英语:Proctalgia fugax) ... 胆汁淤积(英语:Cholestasis)/Mirizzi综合征(英语:Mirizzi's syndrome) ... 贲门粘
Irritable bowel syndrome, celiac disease, inflammatory bowel disease, milk allergy[1]. Treatment. Decreasing lactose in the ... It may be caused by acute gastroenteritis, coeliac disease, Crohn's disease, ulcerative colitis,[30] chemotherapy, intestinal ... Levy J, Bernstein L, Silber N (December 2014). "Celiac disease: an immune dysregulation syndrome". Current Problems in ... Lactose intolerance primarily refers to a syndrome having one or more symptoms upon the consumption of food substances ...
Acute liver failure) · Liver abscess (Pyogenic, Amoebic) · Hepatorenal syndrome · Peliosis hepatis ... Proctitis (Radiation proctitis) · Proctalgia fugax · மலக்குடல் இறக்கம். Anus. Anal fissure/Anal fistula · Anal abscess · Anal ... உணவுக்குழாய் அழற்சி (கண்டிடா, கேர்ப்பிசு) · கிழிவு (Boerhaave syndrome, Mallory-Weiss syndrome) · மேல் இறுக்கி (Zenker's ... Blind loop syndrome · விப்பிள் நோய் · Short bowel syndrome · Steatorrhea · Milroy disease ...
Immune dysfunction - arthritis, systemic lupus erythematosus, Sjögren syndrome, myasthenia gravis, systemic vasculitis, Behcet- ... Blood cell dysfunction - megaloblastic anemia, myelodysplasia, marrow failure, marrow replacement, acute leukemia ... Radiation. *Major surgery. *Miscellaneous - ECMO, kidney or bone marrow transplant, hemodialysis, kidney failure, severe burn, ... Neutrophils are the most common cell type seen in the early stages of acute inflammation. The average lifespan of inactivated ...
Diminished SOD3 activity has been linked to lung diseases such as Acute Respiratory Distress Syndrome (ARDS) or Chronic ... An SOD-mimetic agent, TEMPOL, is currently in clinical trials for radioprotection and to prevent radiation-induced dermatitis.[ ... Overexpression of SOD1 has been linked to the neural disorders seen in Down syndrome.[38] In patients with thalassemia, SOD ... Clinical trial number NCT01324141 for "Topical MTS-01 for Dermatitis During Radiation and Chemotherapy for Anal Cancer" at ...
An example of this is one of the milder forms of Klinefelter syndrome, called 46/47 XY/XXY mosaic wherein some of the patient's ... Exogenous factors include nicotine and UV radiation.[11] Somatic mosaics have been created in Drosophila using X‑ray treatment ... Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1). *Acute promyelocytic leukemia t(15 PML,17 RARA) ... another example of mitotic recombination is the Bloom's syndrome which happens due to the mutation in the blm gene. The ...
General syndromes. *Nephritis. *Nephrosis. *Renal failure *Acute renal failure. *Chronic kidney disease ... radiation therapy, underlying cancer, medications and toxins.[47] Medications that commonly cause this problem include the ... Colgan, R; Williams, M (1 October 2011). "Diagnosis and treatment of acute uncomplicated cystitis". American Family Physician. ... AMDA - The Society for Post-Acute and Long-Term Care Medicine (February 2014), "Ten Things Physicians and Patients Should ...
The diversity of A. mellifera subspecies is probably the product of a largely Early Pleistocene radiation aided by climate and ... Anarchic syndrome is an example of selection working in opposite directions at the individual and group levels for the ... Both G. mellonella adults and larvae are possible vectors for pathogens that can infect bees, including the Israeli acute ... Barron, A., Oldroyd, B, and Ratnieks, F.L.W. (2001) Worker reproduction in honey-bees (Apis) and the anarchic syndrome: a ...
Radiation and health. *Radiation syndrome *acute. *chronic. *Health physics. *Dosimetry. *Electromagnetic radiation and health ... "Cosmic radiation" redirects here. For some other types of cosmic radiation, see Cosmic background radiation and Cosmic ... Average annual radiation exposure (millisieverts) Radiation UNSCEAR[83][84] Princeton[85] Wa State[86] MEXT[87] Remark ... Role in ambient radiation. Cosmic rays constitute a fraction of the annual radiation exposure of human beings on the Earth, ...
Some children may suffer from short bowel syndrome if extensive portions of the bowel had to be removed. ... Complications may include short-gut syndrome, intestinal strictures, or developmental delay.[2] ... survivors are at risk for complications including short bowel syndrome and neurodevelopmental disability. ...
Tourette syndrome. The available data was determined to be insufficient to allow reliable conclusions to be drawn regarding the ... Pate, David W. (1983). "Possible role of ultraviolet radiation in evolution of Cannabis chemotypes". Economic Botany. 37 (4): ... Thompson, George R.; Rosenkrantz, Harris; Schaeppi, Ulrich H.; Braude, Monique C. (July 1973). "Comparison of acute oral ... "UV-B radiation effects on photosynthesis, growth and cannabinoid production of two Cannabis sativa chemotypes". Photochemistry ...
Otitis media -acute. The treatment of branchio-oto-renal syndrome is done per each affected area (or organ). For example, a ... Branchio-oculo-facial syndrome. References[edit]. *^ a b "Branchiootorenal syndrome". Genetics Home Reference. 2015-11-23. ... Diagnosis of BO syndrome or BOR syndrome is clinical, ie based on observing an appropriate combination of symptoms[7]. Only ... The disease may then be termed Branchio-oto Syndrome (BO syndrome)[4]. ...
Radiation and health. *Radiation syndrome *acute. *chronic. *Health physics. *Dosimetry. *Electromagnetic radiation and health ... Stereotactic radiation is a specialized type of external beam radiation therapy. It uses focused radiation beams targeting a ... PROS (Paediatric Radiation Oncology Society). *American Society for Radiation Oncology - ASTRO: the official site for radiation ... Acute side effects[edit]. Nausea and vomiting. This is not a general side effect of radiation therapy, and mechanistically is ...
Irritable bowel syndrome (IBS) is the most common of the functional gastrointestinal disorders. These are idiopathic disorders ...
... associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome". Proceedings of the National ... UV radiation. This could explain why influenza occurs mostly in winter and during the tropical rainy season, when people stay ... In some cases, an autoimmune response to an influenza infection may contribute to the development of Guillain-Barré syndrome.[ ... Sometimes, influenza may have abnormal presentations, like confusion in the elderly and a sepsis-like syndrome in the young.[34 ...
Radiation. and health. *Acute radiation syndrome. *Health physics. *Dosimetry. *Electromagnetic radiation and health ... Electromagnetic radiation in this range of wavelengths is called visible light or simply light. A typical human eye will ... Rough plot of Earth's atmospheric opacity to various wavelengths of electromagnetic radiation, including visible light ...
Medications used to treat cancer can interact with ketorolac along with radiation therapy. The risk of toxicity to the kidneys ... Though uncommon, potentially fatal adverse effects include stroke, myocardial infarction, GI bleeding, Stevens-Johnson syndrome ... "Non-Steroidal Anti-Inflammatory Drugs and Aspirin Therapy for the Treatment of Acute and Recurrent Idiopathic Pericarditis" ...
Radiation acne. Radiation-induced cancer. Radiation recall reaction. Radiation-induced erythema multiforme. Radiation-induced ... Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. Aerosol burn. ... Acute treatment consists of C1-INH (C1-esterase inhibitor) concentrate from donor blood, which must be administered ... Radiation. Radiation poisoning. Radiation burn. Chronic radiation keratosis. Eosinophilic, polymorphic, and pruritic eruption ...
Genomic data are used to identify the genes involvement in unknown or rare conditions/syndromes. Currently, the most vigorous ... were adopted as standards for diagnostic classification and acute care procedure classification. Simultaneously, the ... Working quick acute cases on Homeopathic Software (YouTube) ... Radiation oncology. *Reproductive medicine. *Sexual medicine. * ...
Radiation and health. *Radiation syndrome *acute. *chronic. *Health physics. *Dosimetry. *Electromagnetic radiation and health ... A 2012 study of low-frequency radiation on humans found "no evidence for acute effects of short-term mobile phone radiation on ... "Radiation and Nuclear Safety Authority: Children's mobile phone use should be limited". Finnish Radiation and Nuclear Safety ... Some national radiation advisory authorities, including those of Austria,[37] France,[38] Germany,[39] and Sweden,[40] have ...
Radiation and health. *Radiation syndrome *acute. *chronic. *Health physics. *Dosimetry. *Electromagnetic radiation and health ... Effects of acute radiation exposure[edit]. Phase Symptom Whole-body absorbed dose (Gy) ... "Annex C: Radiation exposures in accidents" (PDF). Sources and Effects of Ionizing Radiation - 2008 Report to the General ... Radiation and other accidents and incidents[edit]. See also: List of civilian radiation accidents and List of nuclear weapons ...
... s are implicated in the emergence of severe acute respiratory syndrome (SARS) in China, since they serve as natural hosts ... Bats may avoid flying during the day to prevent overheating in the sun, since their dark wing-membranes absorb solar radiation ... White nose syndrome is a condition associated with the deaths of millions of bats in the Eastern United States and Canada.[164] ... "White-Nose Syndrome Confirmed in Illinois Bats: Illinois becomes 20th state in U.S. to confirm deadly disease in bats" (PDF). ...
Raveenthiran syndrome[edit]. Dr. Raveenthiran of SRM Hospital, Kattankulathur described a new syndrome in which Spigelian ... Raveenthiran V (Dec 2005). "Congenital Spigelian hernia with cryptorchidism: probably a new syndrome". Hernia. 9 (4): 378-80. ...
Radiation poisoning[edit]. Ataxia can be induced as a result of severe acute radiation poisoning with an absorbed dose of more ... Optic ataxia is usually part of Balint's syndrome, but can be seen in isolation with injuries to the superior parietal lobule, ... The term vestibular ataxia is used to indicate ataxia due to dysfunction of the vestibular system, which in acute and ... Vallar G (July 2007). "Spatial neglect, Balint-Homes' and Gerstmann's syndrome, and other spatial disorders". CNS Spectrums. 12 ...
Shiga toxin causes hemorrhagic colitis and hemolytic-uremic syndrome by damaging endothelial cells in the microvasculature of ... the occurrence of this syndrome is strongly linked to HLA-B27 genotype, but the immunologic basis of this reaction is not ...
DiGeorge syndrome is a genetic disorder caused by the deletion of a small section of chromosome 22. This results in a midline ... Lymphomas or leukemias of thymocyte origin are classified as Precursor T acute lymphoblastic leukemia/lymphoma (T-ALL). People ... with an enlarged thymus, particularly children, were treated with intense radiation in the years before 1950. There is an ... DiGeorge syndrome is the most common congenital cause of thymic aplasia in humans. In mice, the nude mouse strain are ...
Li-Fraumeni syndrome, or neurofibromatosis type 1.[1] Environmental risk factors may include significant radiation exposure or ... Several genetic syndrome also carry increased risk of ALL. These include: Down syndrome, Fanconi anemia, Bloom syndrome, X- ... Acute leukemias of ambiguous lineage *Acute undifferentiated leukemia. *Mixed phenotype acute leukemia (MPAL) with t(9;22)( ... Possible treatments for acute leukemia include chemotherapy, steroids, radiation therapy, intensive combined treatments ( ...
Information on acute radiation syndrome, its symptoms and treatment. Provided by the Centers for Disease Control and Prevention ... Acute Radiation Syndrome (ARS), or radiation sickness, is a serious illness that can happen when a person is exposed to very ... Radiation Dictionary. *Radiation Emergencies & Your Healthplus icon *Possible Health Effectsplus icon *Contamination and ... Cutaneous Radiation Injury (CRI) happens when exposure to a large dose of radiation causes injury to the skin. A doctor will ...
The Acute Radiation Syndrome. Br Med J 1952; 2 doi: https://doi.org/10.1136/bmj.2.4790.925 (Published 25 October 1952) Cite ...
It is being developed as a radiation countermeasure to prevent death from Acute Radiation Syndrome (ARS). ARS would be a major ... Cleveland Biolabs Countermeasure for Acute Radiation Syndrome, Pipeline Review, and Market Potential. ... The market for radiation countermeasures has grown substantially, primarily due to the perceived threat of chemical, biological ... Due to the limitations of the two currently approved treatments to deal with a large-scale radiation event, CBLI believes that ...
... as a treatment for the pulmonary syndrome of acute radiation syndrome (Lung-ARS) and delayed effects of acute radiation ... Home News BARDA Exercises $6M Option for Aeolus Acute Radiation Syndrome Drug ... BARDA Exercises $6M Option for Aeolus Acute Radiation Syndrome Drug. September 18, 2013. 0 ...
Acute Radiation Syndrome / Death Online converter page for a specific unit. Here you can make instant conversion from this unit ... Instant Conversion for Units of Radiation. Radiation Converter. Acute radiation syndrome.. Copyright © 1996-2019 by Sergey ... This is a conversion chart for death (Acute radiation syndrome). To switch the unit simply find the one you want on the page ... Absorbed and equivalent radiation doses can not be directly converted as the conversion depends on the type of radiation. On ...
Acute radiation syndrome (ARS), also called radiation sickness, is the result caused by receiving a dose greater than 75 rads ( ... Acute Radiation Syndrome: A Fact Sheet for Physicians. *↑ 3.0 3.1 3.2 3.3 Waselenko,JK et al. (15 June 2004), "Medical ... Other radiation syndromes can be caused by localized radiation, or a cumulative whole-body exposure over a length of time (e.g ... Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group", ...
Radiation Converter. , Acute Radiation Syndrome. , Purpoura, Hemorrhage, Infections. Convert Purpoura, Hemorrhage, Infections ... These units belong to the same measurement system: Acute Radiation Syndrome. If you need to convert purpoura, hemorrhage, ... Purpoura, Hemorrhage, Infections to Leukopenia , Acute Radiation Syndrome Copyright © 1996-2019 by Sergey Gershtein, Anna ... Absorbed and equivalent radiation doses can not be directly converted as the conversion depends on the type of radiation. On ...
Acute radiation syndrome (ARS) also known as radiation poisoning, radiation sickness or radiation toxicity, is a syndrome or ... "Acute Radiation Syndrome" (PDF). National Center for Environmental Health/Radiation Studies Branch. 2002-04-09. Retrieved 2009- ... June 2010). "Acute radiation syndrome: assessment and management". South. Med. J. 103 (6): 541-6. doi:10.1097/SMJ. ... "Acute Radiation Syndrome: A Fact Sheet for Physicians". Centers for Disease Control and Prevention. 2005-03-18.. ...
ARS occurs when the body is exposed to radiation in excess of four sieverts (the biological dose equivalent of radiation). The ... Affects of acute radiation syndrome (ARS), computer artwork. ... Acute radiation syndrome. M108/0775 Rights Managed. Request low ... Caption: Affects of acute radiation syndrome (ARS), computer artwork. ARS occurs when the body is exposed to radiation in ... Keywords: acute radiation syndrome, adult, artwork, bone, bone marrow, bones, brain, cerebral, concept, concepts, conceptual, ...
Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection of health effects that ... radiation) Nuclear terrorism "A Fact Sheet for Physicians". CDC. CDC Radiation Emergencies Acute Radiation Syndrome. 22 April ... "Time Phases of Acute Radiation Syndrome (ARS) - Dose >8 Gy". Radiation Emergency Medical Management. Retrieved December 1, 2019 ... Donnelly, EH; Nemhauser, JB; Smith, JM; Kazzi, ZN; Farfán, EB; Chang, AS; Naeem, SF (June 2010). "Acute radiation syndrome: ...
Radiation Sickness, Acute Radiation Syndrome) Market Size, Status and Forecast 2025 to its huge collection of research reports ... Radiation Sickness, Acute Radiation Syndrome). 1.1 Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) Market ... Acute Radiation Syndrome) Competition Analysis by Players. 2.1 Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome ... Acute Radiation Syndrome) market, analyzes and researches the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome ...
Acute radiation syndrome. Illnesses collectively called acute radiation syndrome occur within a few hours to months after ... Stram DO, Mizuno S: Analysis of the DS86 atomic-bomb radiation dosimetry using data on severe epilation. Radiation Research ... If the radiation dose is low, the syndrome will seldom if ever occur. Conversely, if the dose is high, death can occur within ... The Figure shows the relation of severe epilation (loss of more than 2/3 of scalp hair) to radiation dose. Although there is ...
... plant accident has prompted rethinking of the contingency plan for prophylaxis and treatment of the acute radiation syndrome ( ... in acute radiation injury has become standard treatment for ARS in the United States, based on the fact that growth factors ... After radiation exposure to the lungs, resting macrophages can no longer be transformed, not even during systemic ... However, GM-CSF is not expressed in radiation injured tissue due to defervescence of the macrophages. In order to maintain the ...
... in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or ... this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. ... G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be ... anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with ...
... the role of annexin A1 in the control of hypoxia and inflammation that is characteristic of acute respiratory-distress syndrome ... based on the transplantation of mesenchymal stromal/stem cells stimulated with radiation, to alleviate the symptoms of patients ... Rationale for the Use of Radiation-Activated Mesenchymal Stromal/Stem Cells in Acute Respiratory Distress Syndrome by Isabel ... "Rationale for the Use of Radiation-Activated Mesenchymal Stromal/Stem Cells in Acute Respiratory Distress Syndrome" Cells 9, no ...
During such an attack, people could suffer from the acute radiation syndrome. This syndrome is the collection of bodily effects ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ...
Development of BIO 301 to Prevent Acute Radiation Syndrome and Mitigate the Delayed Effects of Acute Radiation Exposure Posted ... Development of BIO 301 to Prevent Acute Radiation Syndrome and Mitigate the Delayed Effects of Acute Radiation Exposure ... Development of BIO 301 to Prevent Acute Radiation Syndrome and Mitigate the Delayed Effects of Acute Radiation Exposure ... and acute radiation syndrome (ARS), which affects the hematopoietic and gastrointestinal systems. Building on their Fiscal Year ...
... regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). The FDA provided Pluristem ... Pluristem Concludes Positive Meeting with FDA on Development Plan for Acute Radiation Syndrome. ... regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). The FDA provided Pluristem ... These studies demonstrated PLX-R18 potential to increase survival rates after radiation exposure, as well as protect and ...
Placental Cells Found to Have Potential to Mitigate Acute Radiation Syndrome. Monday, Oct 24 2011Acute Radiation Syndrome (ARS).. During the studies, animals were injected ... "While our experiments using PLX cells in treating radiation exposure are ongoing and still evolving, these initial data are ... post radiation treatment, which could potentially be used in the future for treating ARS patients. ...
Rapid clinical triage of radiation injury patients is essential for determining appropriate diagnostic and therapeutic ... Rapid Prediction of Hematologic Acute Radiation Syndrome in Radiation Injury Patients Using Peripheral Blood Cell Counts Radiat ... specifically for hematologic acute radiation syndrome (HARS). We analyzed BCC test samples from radiation accident victims (n ... 3 c Radiation Medicine Research Group of the Faculty of Medicine, University of Ulm, Ulm, Germany and World Health Organization ...
... in part reflecting an incomplete understanding of mechanisms contributing to the acute radiation-induced GI syndrome (RIGS). ... Eliminating GUCY2C signaling exacerbated RIGS, amplifying radiation-induced mortality, weight loss, mucosal bleeding, ... mediating toxicities restricting the therapeutic efficacy of radiation in cancer and morbidity and mortality in nuclear ... High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal (GI) tract, ...
... and acute myelogenous leukemia (AML) risk associated with radiation and/or chemotherapy breast cancer (BC) treatment. Our study ... those treated with radiation and those treated with radiation and chemotherapy compared to available population incidence data ... A RR of 3.32 (95% CI = 1.42, 6.45) was observed in the surgery/radiation-only group and a RR of 6.32 (95% CI = 3.03, 11.45) in ... 5790 TNM stage 0-III patients treated with surgery alone, radiation and/or chemotherapy were included. Patients without surgery ...
Treatment Acute radiation syndrome. Symptoms and causes Acute radiation syndrome Prophylaxis Acute radiation syndrome ... Acute radiation syndrome». *. CDC Radiation Emergencies , Acute Radiation Syndrome. Acute Radiation Syndrome (ARS): A Fact ... Acute Radiation Syndrome: A Fact .... Acute Radiation Syndrome: A Fact Sheet for Physicians. Acute Radiation Syndrome (ARS) ( ... Acute radiation syndrome definition - Medical Dictionary .... Acute radiation syndrome: An acute illness caused by a dose ...
... biological effects of ionising radiation or radiobiology - experimental studies (dosimetry, reactor physics, radiochemistry), ... Chronic Myelogenic Leukemia, Developed at the Survivor of Acute Radiation Syndrome Severe Degree. N. Nadezhina1, I. Galstyan1, ... sufficient for leading of the first results of supervision of the acute radiation syndrome (ARS) survivors. Among 10 patients ... The most typical is development of acute leukemia and chronic myelogenic leukemia 5-10 years later radiation exposure.. At the ...
... biological effects of ionising radiation or radiobiology - experimental studies (dosimetry, reactor physics, radiochemistry), ... Immunoglobulines to Radiation Toxins were used for a treatment of Acute Radiation Syndromes and the efficacy of this bio- ... Medical management of Acute Radiation Syndromes:Immunotherapy by Antiradiation Immunoglobulin G .. D. Popov1 and V. Maliev2 ... Differential diagnosis of Acute Radiation Syndromes by Enzyme Immune-Assay (EIA) Radioprotection 2008, Vol. 43, n° 5. ...
... a potential therapy for Acute Radiation Syndrome, has been granted Orphan Drug Designation by the U.S. Food and Drug ... Enzychem Lifesciences has announced that EC-18, a potential therapy for Acute Radiation Syndrome (ARS), has been granted Orphan ... Orphan Drug Designation Granted to Potential Acute Radiation Syndrome Treatment. JANUARY 22, 2018 ... ARS is developed after a patient is exposed to high amounts of radiation in a short period of time, breaking down immature ...
Filed Under: New Publications Tagged With: ER beta, ERb, ERβ, estrogen receptor, H-ARS, hematopoietic-acute radiation syndrome ... Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome. ... drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic-acute radiation syndrome (H-ARS). ... Date of publication: 30 April 2019; Journal of Radiation Research. Author information: Michael R. Landauer (1); Adam J. Harvey ...
... is the medical term for the damage occurring to the body after exposure to large amount of radiation within a short period of ... time (24 hours). Know the causes, signs, symptoms, treatment and diagnosis of Acute Radiation Syndrome. ... Other names for Acute Radiation Syndrome are: Acute Radiation Sickness, Radiation Sickness, Radiation Poisoning and Radiation ... Acute Radiation Syndrome consists of the following sub syndromes:. Hematopoietic Syndrome: In this category of acute radiation ...
Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group ... Also called radiation poisoning, radiation toxicity, or radiation sickness.. *Acute illness caused by exposure to high doses ( ... Acute radiation syndrome. Revision as of 05:54, 22 June 2018 by Rossdonaldson1. (talk , contribs) (→‎External Links) ... Acute radiation syndrome: assessment and management. South Med J. 2010 Jun;103(6):541-6. ...
  • Acute Radiation Syndrome (ARS) , or radiation sickness, is a serious illness that can happen when a person is exposed to very high levels of radiation, usually over a short period of time. (cdc.gov)
  • Acute Radiation Syndrome (ARS) (sometimes known as radiation toxicity or radiation sickness) is an acute illness caused by irradiation of the entire body (or most of the body) by a high dose of penetrating radiation in a very short period of time (usually a matter of minutes). (cdc.gov)
  • Acute radiation syndrome (ARS) , also called radiation sickness , is the result caused by receiving a dose greater than 75 rads (0.75 Gray (Gy)) of ionizing radiation [1] to the body in a short time (usually minutes). (citizendium.org)
  • Acute radiation syndrome ( ARS ) also known as radiation poisoning , radiation sickness or radiation toxicity , is a syndrome or group of health effects which occur within months of exposure to high amounts of ionizing radiation . (wikipedia.org)
  • Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection of health effects that are caused by being exposed to high amounts of ionizing radiation, in a short period of time. (wikipedia.org)
  • These symptoms are common to many illnesses, and may not, by themselves, indicate acute radiation sickness. (wikipedia.org)
  • Brooklyn, NY -- ( SBWIRE ) -- 03/06/2018 -- Qyresearchreports include new market research report "Global Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) Market Size, Status and Forecast 2025" to its huge collection of research reports. (sbwire.com)
  • A newly added research report about the global market for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) produces a 360-degree overview of it. (sbwire.com)
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  • This report studies the global Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) market, analyzes and researches the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) development status and forecast in United States, EU, Japan, China, India and Southeast Asia. (sbwire.com)
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  • ARS is also known as radiation sickness or radiation toxicity. (drugster.info)
  • Other names for Acute Radiation Syndrome are: Acute Radiation Sickness, Radiation Sickness , Radiation Poisoning and Radiation Toxicity. (epainassist.com)
  • Also called radiation poisoning, radiation toxicity, or radiation sickness. (wikem.org)
  • Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome)-Pipeline Insights, 2016", report provides in depth insights on the pipeline drugs and their development activities around the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome). (gosreports.com)
  • DelveInsight's Report also provides detailed information on the discontinued and dormant drugs that have gone inactive over the years for Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome). (gosreports.com)
  • DelveInsight's Report also assesses the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) therapeutics by Monotherapy, Combination products, Molecule type and Route of Administration. (gosreports.com)
  • This is known as acute radiation syndrome, commonly known as "radiation sickness. (epa.gov)
  • Radiation sickness is damage to your body caused by a large dose of radiation often received over a short period of time (acute). (pharmacypedia.org)
  • Radiation sickness is also called acute radiation sickness, acute radiation syndrome or radiation poisoning. (pharmacypedia.org)
  • Common exposures to low-dose radiation, such as X-ray or CT examinations, don't cause radiation sickness. (pharmacypedia.org)
  • Although radiation sickness is serious and often fatal, it's rare. (pharmacypedia.org)
  • Since the atomic bombings of Hiroshima and Nagasaki, Japan, during World War II, most cases of radiation sickness have occurred after nuclear industrial accidents such as the 1986 fire that damaged the nuclear power plant at Chernobyl or the 2011 earthquake that damaged the nuclear power plant on the east coast of Japan. (pharmacypedia.org)
  • The severity of signs and symptoms of radiation sickness depends on how much radiation you've absorbed. (pharmacypedia.org)
  • Signs and symptoms of radiation sickness usually appear when the entire body receives an absorbed dose of at least 1 Gy. (pharmacypedia.org)
  • The initial signs and symptoms of treatable radiation sickness are usually nausea and vomiting. (pharmacypedia.org)
  • After the first round of signs and symptoms, a person with radiation sickness may have a brief period with no apparent illness, followed by the onset of new, more serious symptoms. (pharmacypedia.org)
  • An accident or attack that causes radiation sickness would no doubt cause a lot of attention and public concern. (pharmacypedia.org)
  • Radiation sickness is caused by exposure to a high dose of radiation, such as a high dose of radiation received during an industrial accident. (pharmacypedia.org)
  • Radiation sickness occurs when high-energy radiation damages or destroys certain cells in your body. (pharmacypedia.org)
  • A Japanese girl presenting the effects of radiation sickness. (gutenberg.org)
  • These diseases are sometimes referred to as radiation sickness, but they are never included in the term acute radiation syndrome. (gutenberg.org)
  • Symptoms may be local (eg, burns) or systemic (eg, acute radiation sickness). (merckmanuals.com)
  • Patients with severe acute radiation sickness receive reverse isolation, antimicrobial and anti-inflammatory agents, and bone marrow support. (merckmanuals.com)
  • Find out what you need to know about radiation sickness. (disasterassistance.gov)
  • What are the treatments for acute radiation sickness? (medlineplus.gov)
  • Radiation and the Human Body Dr. Richard Besser on the effects of radiation sickness. (go.com)
  • Radiation sickness has haunted humanity since the atomic bombs dropped, killed entire teams of firefighters at the Chernobyl nuclear plant disaster and worries workers trying to fix the Fukushima reactor in Japan. (livescience.com)
  • But no current treatment exists for radiation sickness, which is also known as acute radiation syndrome. (livescience.com)
  • That matters because infections are what often end up killing victims of radiation sickness. (livescience.com)
  • The SNS assembled a working group with representatives from the Centers for Disease Control and Prevention, the U.S. Armed Forces, and universities with expertise in acute radiation injury. (annals.org)
  • Visit the U.S. Centers for Disease Control and Prevention (CDC) for more information about possible health effects of radiation exposure and contamination. (epa.gov)
  • Centers for Disease Control and Prevention (2005) Cutaneous radiation injury: fact sheet for physicians. (springer.com)
  • Studies of therapy effects of Anti-radiation Immunoglobulin G in vivo have established that specific antibodies to Radiation Toxins of SRD group can be important, effective part of medical management of ARS and can play a significant role in neutralization of radiation induced toxicity. (radioprotection.org)
  • Acute and repeated dose 28-day oral toxicity of Chrysobalanusicaco L. leaf aqueous extract. (bioportfolio.com)
  • The acute toxicity study was performed using a dose of AECi 2000 mg/kg, while the repeated dose toxicity study, the AECi was administered daily at doses of 100, 200 and 400 mg/kg, for 28 days. (bioportfolio.com)
  • Acute and 28-day repeated dose oral toxicity study of caraway oil in rats. (bioportfolio.com)
  • Toxicological evaluation of naringin: Acute, subchronic, and chronic toxicity in Beagle dogs. (bioportfolio.com)
  • The market for radiation countermeasures has grown substantially, primarily due to the perceived threat of chemical, biological, radiation, and nuclear attacks. (yahoo.com)
  • Information about the acute radiation syndrome comes from studies of animals, studies of accidents at nuclear power plants, or studies of the effects of the atomic bomb detonated over Hiroshima, Japan. (annals.org)
  • Radiation sources can range from major radioactive materials, such as leaked nuclear fuel seen in the Fukushima Daiichi nuclear disaster, to common X‑ray machines. (army.mil)
  • Examples of persons who suffered from acute radiation syndrome (ARS) are the survivors of the Hiroshima and Nagasaki atomic bombs and the firefighters that first responded after the Chernobyl Nuclear Power Plant event in 1986. (drugster.info)
  • Acute radiation syndrome is rare, and comes from extreme events like a nuclear explosion or accidental handling or rupture of a highly radioactive source. (epa.gov)
  • BARDA is seeking additional proposals for products that potentially could treat or illness and injury from acute radiation syndrome , as well as improved diagnostic tools to measure the radiation dose a person has absorbed after a nuclear denotation or radiation accident. (freethesaurus.com)
  • Accidents involving nuclear reactors such as those that took place in 1986 at Chernobyl and at Fukushima Daiichi after the March 2011 tsunami raise major concerns about what happens if the worst occurs and large numbers of people are simultaneously exposed to high levels of radiation. (news-medical.net)
  • Victims of nuclear disasters present with acute radiation syndrome as a result of exposure to ionizing radiation. (ps-rc.org)
  • Pluristem Therapeutics Inc., a leading developer of placenta-based cell therapy products, has announced the positive results of a recently completed trial conducted by the U.S. National Institutes of Health (NIH) to evaluate PLX-R18 cells to treat bone marrow damaged by exposure to high levels of radiation, such as can occur after a nuclear disaster. (medicalnewstoday.com)
  • Pluristem Therapeutics has announced that its new cell therapy to treat acute radiation syndrome (PLX-R18), based on the pioneering studies performed within the laboratory of Prof. Raphael Gorodetsky at the Hadassah Medical Center, has received clearance from the United States Food and Drug Administration to treat individuals who may have been acutely exposed to high-dose radiation as the result of a nuclear attack or accident. (hadassahinternational.org)
  • TLR2 signaling results in nuclear factor-kappaB (NF-κB)-dependent upregulation of anti-apoptotic factors, anti-oxidants and cytokines, all of which have been implicated in radiation protection. (elsevier.com)
  • Beck, H. L., Krey, P. W. Radiation Exposures in Utah from Nevada Nuclear Tests. (nap.edu)
  • By Elana Ringler Israeli biotech firm Pluristem Therapeutics said it hopes its anti-radiation therapy will protect Fukushima workers decommissioning nuclear reactors and save lives in the future if ever a similar catastrophe occurs. (yahoo.com)
  • We are living in an area which have a variety of threats including nuclear bombs and radiation catastrophes so we developed the product in mind that those may happen. (yahoo.com)
  • In response to concerns over possible radiological or nuclear incidents, the Radiation and Nuclear Countermeasures Program within the National Institute of Allergy and Infectious Diseases (NIAID) was tasked by the U.S. Department of Health and Human Services to support development of medical countermeasures (MCM) to treat the acute and delayed injuries that can result from radiation exposure. (bioone.org)
  • Radiation emergencies can happen because of a terrorist attack or an accident at a nuclear facility. (disasterassistance.gov)
  • The websites below can help you learn how to prepare for a radiation or nuclear event and how you can keep yourself and your family safe during and after. (disasterassistance.gov)
  • Learn the potential radiation exposure danger from a nuclear power plant emergency. (disasterassistance.gov)
  • In contrast to the nontherapeutic radiologic/nuclear incidents and disaster scenarios discussed in the previous article in the series, 1 the present article explores issues associated with routine and accidental exposure from administration of ionizing radiation during routine clinical practice. (jaoa.org)
  • Acute radiation syndrome in Russian nuclear workers. (cdc.gov)
  • But many people remained concerned after Japan's Prime Minister Naoto Kan said the damaged nuclear reactors may spew further radiation. (go.com)
  • Three nuclear plant workers have suffered from acute radiation syndrome, the New York Times reported. (go.com)
  • The World Nuclear Association says the lowest level of radiation that is clearly at a carcinogenic level is 100 millisieverts per year. (go.com)
  • Disasters such as those at the Fukushima Daiichi Nuclear Power Plant and the Chernobyl Nuclear Power Plant, emphasize the need for available and effective therapeutic options to mitigate and treat the damaging effects of exposure to lethal doses of ionizing radiation. (science.edu.sg)
  • In all likelihood, the nuclear crisis playing out in Japan would be far worse if not for a crew of 50 to 100 workers braving explosions, heat and radiation. (livescience.com)
  • John Lee, a professor of nuclear engineering at the University of Michigan, said that acceptable levels of radiation are typically much lower - 50 mSv per year - "but this limit may be exceeded somewhat in emergency situations. (livescience.com)
  • Kim Kearfott, another professor of nuclear engineering at the University of Michigan, said there are a several radiation checkpoints in place to protect the workers. (livescience.com)
  • This experience has provided epidemiologists useful data on radiation exposure," he said, adding that the nuclear crisis at the Fukushima plants is not yet on par with the Chernobyl disaster . (livescience.com)
  • Machine generated contents note: Section I: For Students of Diagnostic Radiology, Nuclear Medicine, and Radiation Oncology 1. (helsinki.fi)
  • Part I contains 17 chapters and represents both a general introduction to radiation biology and a complete self-contained course in the subject, suitable for residents in diagnostic radiology and nuclear medicine. (helsinki.fi)
  • About 50 to 100 Japanese workers risked radiation and explosions to prevent complete meltdown of nuclear reactors at the Fukushima plant. (livescience.com)
  • These studies demonstrated PLX-R18 potential to increase survival rates after radiation exposure, as well as protect and regenerate the bone marrow's ability to produce blood cells, crucial for victims exposed to high levels of radiation. (apnews.com)
  • Exposure to low levels of radiation encountered in the environment does not cause immediate health effects, but is a minor contributor to our overall cancer risk. (epa.gov)
  • Exposure to low-levels of radiation does not cause immediate health effects, but can increase the risk of cancer over a lifetime. (epa.gov)
  • Injection of PLX-R18 cells into muscle, as compared to a placebo , resulted in a statistically significant improvement in the recovery of white blood cell, red blood cell, and platelet levels in animals exposed to high levels of radiation. (medicalnewstoday.com)
  • High levels of radiation can destroy the body's ability to produce these three blood lineages, and rapidly regaining that capacity is a key factor in surviving the hematologic component of acute radiation syndrome (ARS), a condition caused by high-dose irradiation that can involve severe, sometimes lethal damage to the bone marrow as well as other physiologic systems and organs. (medicalnewstoday.com)
  • Our PLX-R18 cell product was developed and targeted to become a strong candidate for government procurement programs designed to protect the population in the case of exposure to dangerous levels of radiation. (medicalnewstoday.com)
  • The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. (globenewswire.ca)
  • These findings, which show recovery of the hematologic system, suggest that PLX-R18 has the potential to treat a large population exposed to different levels of radiation and might also be used for additional hematologic indications. (globenewswire.ca)
  • For example, Pluristem is using forward-looking statements when its discusses that PLX-R18 has the potential to treat a large population exposed to different levels of radiation and might also be used for additional hematologic indications, and the potential market for such indications. (globenewswire.ca)
  • The scientists say that exposure to higher levels of radiation raises lifetime cancer risk 'slightly' . (medicalnewstoday.com)
  • The effect of the treatment has been tested on different levels of radiation, including a level of radiation that could cause up to 70 percent mortality rate, Lukasiewicz Hagai said. (yahoo.com)
  • Exposure to low levels of radiation in the environment does not cause immediate health effects. (medlineplus.gov)
  • Such a therapy might even work up to several days after exposure to dangerous levels of radiation , according to Ram Mandalam, president and CEO of Cellerant Therapeutics. (livescience.com)
  • But the biotech company soon found that the treatment worked well enough in its two Phase I clinical safety trials to possibly defend against higher levels of radiation. (livescience.com)
  • If you have these symptoms after a radiation emergency, seek medical attention as soon as emergency officials determine it is safe to do so. (cdc.gov)
  • After the initial symptoms, a person usually looks and feels healthy for a period of time, after which he or she will become sick again with variable symptoms and severity that vary depending on the radiation dose that he or she received. (cdc.gov)
  • the full syndrome will usually occur with a dose greater than approximately 0.7 Gy (70 rads) although mild symptoms may occur as low as 0.3 Gy or 30 rads. (cdc.gov)
  • In this stage the symptoms depend on the specific syndrome and last from hours up to several months. (citizendium.org)
  • The signs and symptoms of this form of radiation injury include nausea, vomiting, loss of appetite, and abdominal pain. (wikipedia.org)
  • These symptoms may occur at radiation doses as low as 0.35 grays (35 rad). (wikipedia.org)
  • Cutaneous radiation syndrome (CRS) refers to the skin symptoms of radiation exposure. (wikipedia.org)
  • Except for vomiting, these signs and symptoms are closely related to frequency of cell division, rapid cell division being more sensitive to radiation than slow division (e.g., muscle and nerve cells). (rerf.jp)
  • Published information supports a strategy in which health care providers first assess the radiation dose to an individual patient on the basis of symptoms and blood counts during the days after exposure. (annals.org)
  • Symptoms and consequences of the acute radiation syndrome vary depending on the amount of exposure but can include nausea, vomiting, diarrhea, confusion, skin burns, low blood pressure or shock, infections, breathing difficulty, and death. (annals.org)
  • Onset of the symptoms and the type of symptoms depends on the radiation exposure. (epainassist.com)
  • If the patient has had comparatively smaller doses of radiation exposure then he/she will experience gastrointestinal symptoms, such as nausea and vomiting. (epainassist.com)
  • The severity of symptoms occurring in Acute Radiation Syndrome depends on the amount of radiation absorbed by the patient. (epainassist.com)
  • Symptoms of Acute Radiation Syndrome also depend on the type of radiation exposure for example if a part of the body has been exposed or if the complete body has been exposed to the radiation. (epainassist.com)
  • The sensitivity of the affected tissues also determines the intensity of the symptoms of Acute Radiation Syndrome. (epainassist.com)
  • Symptoms of Acute Radiation Syndrome appear when the complete body receives and absorbs a radiation dose of a minimum of 1 Gy. (epainassist.com)
  • The greater the radiation exposure, the more severe and rapid are the symptoms of acute radiation exposure. (epainassist.com)
  • Nausea and vomiting comprise of the initial signs and symptoms of acute radiation syndrome, which is treatable. (epainassist.com)
  • [3] The speed of onset of symptoms is related to radiation exposure, with greater doses resulting in a shorter delay in symptom onset. (mdwiki.org)
  • A very high level of radiation exposure delivered over a short period of time can cause symptoms such as nausea and vomiting within hours and can sometimes result in death over the following days or weeks. (epa.gov)
  • Signs and symptoms also are affected by the type of exposure - such as total or partial body and whether contamination is internal or external - and how sensitive to radiation the affected tissue is. (pharmacypedia.org)
  • The amount of time between exposure and when these symptoms develop is an indicator of how much radiation a person has absorbed. (pharmacypedia.org)
  • In general, the greater your radiation exposure, the more rapid and more severe your symptoms will be. (pharmacypedia.org)
  • Immediately after exposure, the most critical components of acute radiation syndrome are the hematopoietic (bone marrow) and early-onset gastrointestinal (GI) syndromes because symptoms begin very quickly and can be lethal. (freethesaurus.com)
  • Similar symptoms may appear months to years after exposure as chronic radiation syndrome when the dose rate is too low to cause the acute form. (gutenberg.org)
  • The person's symptoms will vary depending on the level of radiation they received, but some of the symptoms include loss of appetite, fatigue, fever, nausea, vomiting, diarrhea, and possibly even seizures and coma. (health.com)
  • Diagnosis is by history of exposure, symptoms and signs, and sometimes use of radiation detection equipment to localize and identify radionuclide contamination. (merckmanuals.com)
  • Curious because Arafat didn't demonstrate the classic symptoms of acute radiation syndrome . (wired.com)
  • How soon they get sick again, which symptoms they have, and how sick they get depends on the amount of radiation they received. (medlineplus.gov)
  • They will ask about your symptoms, do blood tests, and may use a device that measures radiation. (medlineplus.gov)
  • For all forms of the syndrome, the most common presenting symptoms and signs, occurring in more than two thirds of patients, include the following: abdominal pain (particularly originating in the right upper quadrant), abdominal distension with ascites and hepatomegaly. (clinicaladvisor.com)
  • There are no FDA-approved drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic-acute radiation syndrome (H-ARS). (indigobiosciences.com)
  • The entire body (or a significant portion of it) must have received the dose.3 o Most radiation injuries are local, frequently involving the hands, and these local injuries seldom cause classical signs of ARS. (cdc.gov)
  • We are pleased to see interest from key governmental agencies such as NIAID, the U.S Department of Defense and BARDA in our novel regenerative medical countermeasure for radiation injuries and look forward to potentially supporting such medical needs of the U.S. government. (apnews.com)
  • For example, Pluristem is using forward-looking statements when it states its belief that, as a result of its meeting with the FDA, it has a clear and efficient path towards advancing the development of PLX-R18 in the treatment of ARS and its potential support of the U.S. government with respect to its medical needs relating to radiation injuries. (apnews.com)
  • At development leukemia at ARS survivors, "hyperregeneration" - hemopoesis with increasing of neutrophils amount (in the absence of consequences of local radiation injuries) within the first years after an irradiation can form a basis for leukogenic transformation. (radioprotection.org)
  • Cell technologies for replacement of skin defects at the patient with local radiation injuries. (radioprotection.org)
  • Colwell CB: Radiation injuries, in Marx JA, Hockberger RS, Walls RM, et al (eds): Rosen's Emergency Medicine: Concepts and Clinical Practice, ed 8. (wikem.org)
  • WASHINGTON -- Two contracts for advanced development of drugs to treat skin and lung injuries associated with acute radiation syndrome (ARS) were awarded this week by the U. (freethesaurus.com)
  • A clear attribution of causes of death to burns, injuries or radiation was impossible because the shock and heat waves also had to be taken into account. (bfs.de)
  • On the basis of a manual published recently by the Norwegian Center for NBC Medicine, Oslo University Hospital Ullevål, a centre for disaster medicine, we here present the main principles for medical treatment of radiation injuries - from first aid at the scene of injury to hospital treatment. (tidsskriftet.no)
  • Our novel approach of DRCC transplantation may act as a bridging therapy supporting hematopoietic recovery and ameliorating injuries in patients exposed to the harmful effects of radiation. (ps-rc.org)
  • For these reasons, the NIAID and the Radiation Injury Treatment Network organized a workshop to explore the use of growth factors and other cytokines as MCMs in the treatment of radiation-induced injuries. (bioone.org)
  • Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs. (iu.edu)
  • Berger ME, Christensen DM, Lowry PC et al (2006) Medical management of radiation injuries: current approaches. (springer.com)
  • In the third of 5 articles on the management of injuries and illnesses caused by ionizing radiation, the authors provide a clinically relevant overview of the pathophysiologic process associated with potential exposure to ionizing radiation. (jaoa.org)
  • To appreciate the systemic pathophysiologic process of ionizing radiation injuries and illnesses, it is necessary to understand how ionizing radiation causes subcellular, cellular, tissue, and organ damage. (jaoa.org)
  • New York State Potassium Iodide (KI) and Radiation Emergencies: Fact Sheet. (wikem.org)
  • Read frequently asked questions about the use of KI in radiation emergencies. (disasterassistance.gov)
  • It is generally divided into three types: bone marrow, gastrointestinal, and neurovascular syndrome, with bone marrow syndrome occurring at 0.7 to 10 Gy, and neurovascular syndrome occurring at doses that exceed 50 Gy. (wikipedia.org)
  • Each syndrome requires that the tissue showing the syndrome itself be exposed (e.g., gastrointestinal syndrome is not seen if the stomach and intestines are not exposed to radiation). (wikipedia.org)
  • Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. (mdpi.com)
  • Exposure to ionizing radiation can lead to cellular DNA damage that can cause health issues such as cancer, diabetes, heart disease, lung fibrosis, liver fibrosis, kidney fibrosis, and acute radiation syndrome (ARS), which affects the hematopoietic and gastrointestinal systems. (army.mil)
  • There are three ARS syndromes: the bone marrow syndrome (or hematologic syndrome), the gastrointestinal (GI) syndrome, and the cardiovascular (CV)/ central nervous system (CNS) syndrome. (drugster.info)
  • Parts of the body, which are most vulnerable to the high dose radiation, are cells that line the gastrointestinal tract and the cells, which produce bone marrow. (epainassist.com)
  • As mentioned before, the bone marrow and the gastrointestinal system are extremely sensitive to radiation. (epainassist.com)
  • The gastrointestinal syndrome is not seen if the stomach and intestines are not exposed to radiation. (mdwiki.org)
  • For instance, the gastrointestinal system and bone marrow are highly sensitive to radiation. (pharmacypedia.org)
  • Soligenix is also developing OrbeShield(TM) for the treatment of gastrointestinal acute radiation syndrome (GI ARS) under a BARDA contract award valued up to $26. (freethesaurus.com)
  • In response to an invitation from the Biomedical Advanced Research and Development Authority (BARDA), we submitted a contract proposal to support the development of OrbeShield (TM) for the treatment of gastrointestinal acute radiation syndrome (GI ARS), which if awarded, has the potential to be a multi-million dollar contract. (freethesaurus.com)
  • In cell and animal models, Ex-RAD protects hematopoietic and gastrointestinal tissues from radiation injury when given either before or after exposure. (wikipedia.org)
  • Pluristem Therapeutics' Vice President of Medical and Clinical Affairs Dr. Esther Lukasiewicz Hagai said cells grown from placentas donated by women who had undergone a C-section, are harvested to create a cocktail of therapeutic proteins which combat potentially lethal damage to the lungs, skin, bone marrow and gastrointestinal tract caused by radiation exposure. (yahoo.com)
  • Infections caused by ionizing radiation can be endogenous, originating from the oral and gastrointestinal bacterial flora, and exogenous, originating from breached skin following trauma. (wikipedia.org)
  • The patient that develops neutropenia after radiation is susceptible to irradiation damage to other tissues, such as the gastrointestinal tract, lungs and the central nervous system. (wikipedia.org)
  • ARS differs from chronic radiation syndrome, which occurs following prolonged exposures to relatively low doses of radiation. (wikipedia.org)
  • During the studies, animals were injected intravenously with either PLX cells or a placebo, on the day after being exposed to lethal doses of radiation. (hadassah.org)
  • Death of laboratory animals had occurred within 5 min-3 days after injection of toxic doses of Radiation Neuro-Toxin and depended on a concentration and a type of active substance of Radiation Toxins. (radioprotection.org)
  • Hyper-immunization of non-irradiated animals by non-toxic doses of Radiation Toxins were provided. (radioprotection.org)
  • Acute radiation syndrome refers to the acute medical problems, which the patient experiences within 24 hours of exposure to extremely high or lethal doses of radiation. (epainassist.com)
  • Neulasta is indicated to increase survival in patients acutely exposed to myelosuppressive doses of radiation [see DOSAGE AND ADMINISTRATION and Clinical Studies ]. (rxlist.com)
  • In particular, this irradiator is dedicated more specifically to the fields of radiobiology, the adverse effects of interventional radiology, the adverse effects of high doses of radiation delivered during certain types of radiotherapy, especially stereotactic radiation therapy. (irsn.fr)
  • Exposure to higher doses of radiation is associated with systemic anaerobic infections due to gram negative bacilli and gram positive cocci. (wikipedia.org)
  • It is being developed as a radiation countermeasure to prevent death from Acute Radiation Syndrome (ARS). (yahoo.com)
  • Filgrastim ('Neupogen') a hematopoietic countermeasure of acute radiation syndrome (ARS). (wikipedia.org)
  • The well-documented effect of the growth factors (granulocyte colony-stimulating factor [G-CSF] and granulocyte-macrophage colony-stimulating factor [GM-CSF]) in acute radiation injury has become standard treatment for ARS in the United States, based on the fact that growth factors increase number and functions of both macrophages and granulocytes. (dovepress.com)
  • Breast cancer incidence in U.S. radiologic technologists is elevated in those who experienced daily low-dose radiation exposures over several years that potentially resulted in appreciable cumulative exposure. (greenmedinfo.com)
  • The pilot research was carried out with DOE support (January 1997) to evaluate the possibility of applying primary clinical and dosimetry data available at FIB-l and Mayak P A to the study of deterministic effects from occupational radiation exposures. (cdc.gov)
  • We examined the utility of blood cell counts (BCCs) in the first three days postirradiation to predict clinical outcome, specifically for hematologic acute radiation syndrome (HARS). (nih.gov)
  • The increased risk of terrorist acts that could involve the use of radioactive sources calls for us to be prepared that a major radiation incident may occur in our country as well. (tidsskriftet.no)
  • The changed threat picture, with an increased risk of terrorist acts involving the use of radioactive sources ( 2 , 3 ), calls for the preparation of clear plans for responses to major radiation incidents. (tidsskriftet.no)
  • This was used for a theoretical exercise arranged by the Norwegian Radiation Protection Authority in 2008, the scenario for which was that members of a terrorist organization had placed a radioactive source under a seat in an underground train. (tidsskriftet.no)
  • Another possible use of a radiation source for terrorist purposes involves so-called «dirty bombs», i.e. conventional explosives mixed with radioactive material. (tidsskriftet.no)
  • The manual describes principles for assessment of the scene of injury in the case of radiation accidents, criteria for selection of patients with regard to their treatment priority (triage), procedure for decontamination of patients who have been exposed to radioactive pollution and guidelines for medical treatment. (tidsskriftet.no)
  • In a radiation accident, a distinction is made between external radiation from a point source and the radioactive pollution described above. (tidsskriftet.no)
  • Individuals should drink plenty of fluids and void frequently to promote dilution of the radioactive chelate in the urine and minimize radiation exposure directly to the bladder. (rxlist.com)
  • Because dialysis fluid will become radioactive, radiation precautions must be taken to protect personnel, other patients, and the general public. (rxlist.com)
  • Ionizing radiation is emitted by radioactive elements and by equipment such as x-ray and radiation therapy machines. (merckmanuals.com)
  • This energetic radioactive element emits alpha radiation which does not penetrate the skin so that it can be safely carried by an assassin. (wired.com)
  • Last July, Al Jazeera published test results from the Institute for Radiation Physics in Lausanne, Switzerland which had found such circumstantial radioactive evidence in his clothing and other effects. (wired.com)
  • ABC News contacted a dozen experts on radiation and, while most said that it is unlikely that the radioactive material will have severe health repercussions on those in Fukushima for now, doctors also agreed that it is too early to tell what will happen as the situation continues. (go.com)
  • The Japanese government has dispensed more than 200,000 units of potassium iodide , a drug commonly used to treat low-level radiation exposure, which would block radioactive iodine to prevent thyroid cancers. (go.com)
  • This article lists notable civilian accidents involving radioactive materials or involving ionizing radiation from artificial sources such as x-ray tubes and particle accelerators . (wikipedia.org)
  • The damage must be related directly to radioactive materials or ionizing radiation from a man-made source, not merely taking place at a facility where such are being used. (wikipedia.org)
  • She was known to carry test tubes full of radioactive isotopes in her pocket, and to store them in her desk drawer, resulting in massive exposure to radiation. (wikipedia.org)
  • This is a Phase I, open-label, multi-center, dose-escalation study of lenalidomide in adult patients with newly diagnosed, relapsed or refractory acute myeloid leukemia. (bioportfolio.com)
  • acute myeloid leukemia lub acute myelogenous leukemia , AML lub acute non-lymphoblastic leukemia , ANLL ) - grupa chorób spowodowana nowotworowym rozrostem w szpiku wczesnych komórek prekursorowych krwi. (wikipedia.org)
  • The most typical is development of acute leukemia and chronic myelogenic leukemia 5-10 years later radiation exposure. (radioprotection.org)
  • Development Ph-positive chronic myelogenic leukemia has occurred later - after 21 year after radiation exposure. (radioprotection.org)
  • MRLs are derived for acute (1-14 days), intermediate (15-364 days), and chronic (365 days and longer) durations and for the oral, inhalation, and external routes of exposure. (cdc.gov)
  • Chronic changes can be a result of long-term low-level exposure or the sequelae of a single episode of high-dose radiation. (springer.com)
  • Those presenting with fulminant and acute forms are more likely to be female and one third or more present with jaundice or with altered mental status due to hepatic encephalopathy, which are both uncommon in subacute and chronic BCS. (clinicaladvisor.com)
  • Subacute or chronic BCS, which is more common than the acute forms in most reported series, should be considered in all patients presenting with unexplained liver disease. (clinicaladvisor.com)
  • The bone marrow syndrome is characterized by anorexia (lack of appetite), fever, and malaise. (drugster.info)
  • The TBI dose ranges against which sLP are effective indicate that sLP primarily impact the hematopoietic (HP) component of acute radiation syndrome. (elsevier.com)
  • Working groups on the management of acute radiation syndrome have been established [ 2 , 3 ]. (mdpi.com)
  • Dainiak N. Medical management of acute radiation syndrome and associated infections in a high-casualty incident . (nlm.gov)
  • ARS occurs when the body is exposed to radiation in excess of four sieverts (the biological dose equivalent of radiation). (sciencephoto.com)
  • This syndrome typically occurs at absorbed doses greater than 30 grays (3,000 rad), though it may occur at 10 grays (1,000 rad). (wikipedia.org)
  • Moreover, since our previous work indicated that PLX cells can enhance the engraftment of hematopoietic stem cells from cord blood, we can offer a multifaceted approach to reduce and treat the destruction of bone marrow that occurs following exposure to high-dose ionizing radiation. (hadassah.org)
  • Acute radiation syndrome involves a total dose of greater than 0.7 Gy (70 rads), that generally occurs from a source outside the body within minutes. (mdwiki.org)
  • Acute radiation syndrome occurs when a person is exposed to a high dose of external penetrating radiation within a short time. (medindia.net)
  • Principal investigator Melpo Christofidou-Solomidou of the Perelman School of Medicine at the University of Pennsylvania and colleagues found that a diet of flaxseed given to mice not only protects lung tissues before exposure to radiation, but also can significantly reduce damage after exposure occurs. (medindia.net)
  • Exposure to harmful radiation occurs very rarely in our country, and only one case resulting in serious health injury is known to date ( 1 ). (tidsskriftet.no)
  • According to the CDC , acute radiation syndrome occurs when a person is exposed to a very high level of radiation in a short period of time. (health.com)
  • Population exposure to ionizing radiation mainly occurs from natural sources or from medical devices. (springer.com)
  • Acute, high-dose exposure usually occurs due to accidental exposure and can lead to significant immediate and long-term medical problems. (springer.com)
  • If such an event occurs, those trained in the radiation sciences will be called on to manage exposed individuals. (helsinki.fi)
  • If you were exposed to certain types of radiation, your provider may give you a treatment that limits or removes the contamination that is inside your body. (medlineplus.gov)
  • Radiation accidents are fortunately infrequent but their health consequences are serious and they have the potential of resulting in large-scale events [ 1 ]. (mdpi.com)
  • We analyzed BCC test samples from radiation accident victims (n = 135) along with their clinical outcome HARS severity scores (H1-4) using the System for Evaluation and Archiving of Radiation Accidents based on Case Histories (SEARCH) database. (nih.gov)
  • In Korea , there were repeated radiation exposure accidents among non-destructive testing workers . (bvsalud.org)
  • Strict legal amendments to safety procedures are essential to prevent repeated radiation exposure accidents . (bvsalud.org)
  • The committee said that the six people's deaths were linked to either previous health problems or non-radiation accidents. (medicalnewstoday.com)
  • Fliedner TM, Friescke I, Beyrer K (2001) Medical management of radiation accidents: manual on the acute radiation syndrome. (springer.com)
  • Mettler FA, Kelsey CA, Ricks RC (1990) Medical management of radiation accidents. (springer.com)
  • Oak Ridge Institute for Science and Education, ORISE-EHSD-REAC/TS (2000) Radiation accidents registries. (springer.com)
  • The radiation must be penetrating [i.e., ionizing]. (citizendium.org)
  • Regulation of ERβ-mediated gene expression by genistein dictates the extent, severity, and response to DNA damage from ionizing radiation, which confer a radioresistant state to healthy cells. (army.mil)
  • Acute illness caused by exposure to high doses (at least 1 Gy) [1] of ionizing radiation over a short period of time. (wikem.org)
  • Ionizing radiation Radiation with so much energy it can knock electrons out of atoms. (epa.gov)
  • Ionizing radiation can affect the atoms in living things, so it poses a health risk by damaging tissue and DNA in genes. (epa.gov)
  • EPA bases its regulatory limits and nonregulatory guidelines for public exposure to low level ionizing radiation on the linear no-threshold (LNT) model. (epa.gov)
  • Ionizing radiation can damage living tissue in the human body. (medindia.net)
  • Transplantation of DRCC after ionizing radiation exposure proved to be the most effective rescue therapy against acute radiation syndrome, as confirmed by 100% of recipients' survival and expedited recovery of the hematopoietic system without developing GVHD. (ps-rc.org)
  • Effect on intelligence test score of prenatal exposure to ionizing radiation in Hiroshima and Nagasaki: A comparison of the T65DR and DS86 dosimetry systems. (cdc.gov)
  • Herein, we report a case of acute radiation syndrome caused by short periods of high exposure to ionizing radiation . (bvsalud.org)
  • Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (merckmanuals.com)
  • One of the IRSN's missions consists of evaluating the risks related to the use of ionizing radiation in the medical sphere and in accidental situations. (irsn.fr)
  • The images are then used to plan treatment using the Muriplan software, which provides for the most appropriate adaptation of distribution of the dose of ionizing radiation to the region we want to irradiate, thus mimicking the irradiation conditions met during application of clinical radiotherapy protocols. (irsn.fr)
  • Anno GH, Young RW, Bloom RM et al (2003) Dose response relationships for acute ionizing-radiation lethality. (springer.com)
  • EC (1996) Council Directive 96/29/Euratom of 13 May 1996 of the European Union laying down basic safety standards for the protection of the health workers and the general public against the dangers arising from ionizing radiation. (springer.com)
  • Health and Safety Executive Ionizing radiation. (springer.com)
  • IAEA (1996) IAEA safety series: international basic safety standards for protection against ionizing radiation and for the safety of radiation sources. (springer.com)
  • Karagas MR, Mc Donald JA, Greenberg ER et al (1996) Risk of basal cell and squamous cell skin cancers after ionizing radiation therapy. (springer.com)
  • In: Medical effects of ionizing radiation. (springer.com)
  • Ionizing radiation exposure can induce profound changes in intracellular components, potentially leading to diverse health effects in exposed individuals. (jaoa.org)
  • Purposeful exposure of patients to ionizing radiation has been a staple in the practice of medicine since the use of the first x-rays more than 100 years ago. (jaoa.org)
  • Whether for general radiologic study or for targeted administration in cancer therapy, most physicians will, on a daily basis, encounter a patient who has been exposed to ionizing radiation. (jaoa.org)
  • Mettler FA Jr, Upton AC: Medical Effects of Ionizing Radiation, 3rd ed. (nlm.gov)
  • Therefore, we also included a chapter on fundamental concepts in molecular imaging that involves ionizing radiation such as CAT scans and PET imaging to reflect these new advances and describe the underlying biologic principles for each of these technologies (Chapter 15). (helsinki.fi)
  • Infections caused by exposure to ionizing radiation can be extremely dangerous, and are of public and government concern. (wikipedia.org)
  • Numerous studies have demonstrated that the susceptibility of organisms to systemic infection increased following exposure to ionizing radiation. (wikipedia.org)
  • Organisms causing sepsis following exposure to ionizing radiation: The management of established or suspected infection following exposure to radiation (characterized by neutropenia and fever) is similar to that used for other febrile neutropenic patients. (wikipedia.org)
  • Our objective was to measure myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) risk associated with radiation and/or chemotherapy breast cancer (BC) treatment. (biomedcentral.com)
  • Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: a study of the Hoosier Oncology Group. (iu.edu)
  • ONTX is conducting a pivotal Phase 3 trial of rigosertib under a Special Protocol Assessment, or SPA, from the U.S. Food and Drug Administration, or FDA, for higher risk myelodysplastic syndromes, or MDS. (equities.com)
  • Cleveland Biolab's development efforts are related to apoptosis, a regulated form of cell death that can occur in response to exposure to radiation or toxic chemicals. (yahoo.com)
  • If the radiation injury itself is fatal, death will occur in no more than a few months. (citizendium.org)
  • Sources of such radiation can occur accidentally or intentionally. (wikipedia.org)
  • Illnesses collectively called 'acute radiation syndrome' occur within a few hours to months after exposure to high-dose radiation (from approximately 1-2 Gy to 10 Gy). (rerf.jp)
  • If the radiation dose is low, the syndrome will seldom if ever occur. (rerf.jp)
  • Exposure to a high dose of radiation, which can occur in an industrial accident, will cause Acute Radiation Syndrome. (epainassist.com)
  • Acute radiation syndrome can occur at 1Sv (1000mSv). (medicalnewstoday.com)
  • Radiation can occur naturally or be man-made. (medlineplus.gov)
  • Biologically, our cells have mechanisms to repair the kind of small amounts of damage that occur daily due to background radiation and other causes, so it is quite possible, even likely, that doses below a certain point do not have the effect of causing increased cancer risk," said David Rocke, distinguished professor of biostatistics at the University of California, Davis. (go.com)
  • The new data were to be used to test the triage scheme that had been developed by Thoma and Wald in 1959 to provide clinicians without any special knowledge about radiation effects with early diagnostic and prognostic information about the severity of such injury as a basis for medical management. (cdc.gov)
  • 4 o The survival rate of patients with this syndrome decreases with increasing dose. (cdc.gov)
  • Unless the exposure causing the syndrome was caused by a well-understood incident to a small number of people, patients presenting with the syndrome should cause an emergency management response. (citizendium.org)
  • What does the SNS Radiation Working Group suggest that patients and doctors do? (annals.org)
  • BIO 300 Oral Suspension is being developed as a supportive care agent for cancer patients undergoing radiation therapy via self-administration with pre-loaded oral syringes, and is currently being evaluated in a Phase 1b/2a clinical trial (NCT02567799). (army.mil)
  • Over the next few months, Prof. Gorodetsky and his team will focus on better understanding the PLX cells' mechanism of action as an "off the shelf" post radiation treatment, which could potentially be used in the future for treating ARS patients. (hadassah.org)
  • Rapid clinical triage of radiation injury patients is essential for determining appropriate diagnostic and therapeutic interventions. (nih.gov)
  • Clinical outcome of radiation injury patients can be rapidly predicted within the first three days postirradiation using peripheral BCC. (nih.gov)
  • 5790 TNM stage 0-III patients treated with surgery alone, radiation and/or chemotherapy were included. (biomedcentral.com)
  • In the current study we report the incidence of MDS and AML in breast cancer patients treated with surgery alone, surgery plus radiation and/or chemotherapy and compare the rates to those obtained from SEER incidence data. (biomedcentral.com)
  • Use of the OBI for Neulasta is not recommended for patients with Hematopoietic Subsyndrome of Acute Radiation Syndrome . (rxlist.com)
  • 90% of the breast cancers in Hodgkin's lymphoma patients receiving radiation are due to radiotherapy-associated uses. (greenmedinfo.com)
  • Breast cancer risk may increase in patients exposed to therapeutic ionising radiation. (greenmedinfo.com)
  • The Haifa-based company said they have developed a placenta-based cell therapy injection that can fully cure patients with multiple organ failure caused by high radiation exposure. (yahoo.com)
  • The curriculum covers emergency department preparedness for receiving multiple pediatric patients, and conducting an acute assessment, diagnosis and stabilization of the severely injured child. (constantcontact.com)
  • Because they have not yet had time to develop venous collaterals and they often have involvement of all the major hepatic veins, patients with acute BCS tend to be more symptomatic, often with intractable ascites and evidence of hepatic necrosis. (clinicaladvisor.com)
  • Cellerant Therapeutics first considered CLT-008 as a way to boost the immune system of patients who receive radiation as part of chemotherapy for cancer. (livescience.com)
  • 14 patients with nasopharyngeal carcinoma with 15 carotid blowout syndromes, initially treated by RT alone. (wikibooks.org)
  • Multiple-organ failure at Acute Radiation Syndromes is a major cause of mortality after high doses of gamma irradiation. (radioprotection.org)
  • ARS is developed after a patient is exposed to high amounts of radiation in a short period of time, breaking down immature parenchymal stem cells in tissues due to the irradiation of the entire body. (raredr.com)
  • In the passive avoidance and object recognition memory test, mice trained for 1 day after acute irradiation (2 Gy) showed significant memory deficits compared with sham controls. (bvsalud.org)
  • Therefore, GT may attenuate memory defects in adult mice exposed to a relatively low dose of radiation possibly by inhibiting the detrimental effects of irradiation on hippocampal neurogenesis . (bvsalud.org)
  • HAIFA, Israel, Jan. 03, 2019 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (Nasdaq:PSTI) (TASE:PSTI), a leading regenerative medicine company developing novel placenta-based cell therapy products, today announced it has concluded a positive meeting with the U.S. Food and Drug Administration (FDA) regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). (apnews.com)
  • Data will be jointly presented at the upcoming 2019 Radiation Injury Treatment Network (RITN) Workshop on July 31st HAIFA, Israel, July 17, 2019 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (thestreet.com)
  • Human efficacy studies to evaluate radiation medical countermeasures are not ethical, thus these studies are designed to meet the FDA's guidance for approval under the Animal Rule. (army.mil)
  • Immunoglobulines to Radiation Toxins were used for a treatment of Acute Radiation Syndromes and the efficacy of this bio-pharmaceutical agent was initially evaluated. (radioprotection.org)
  • Renal disorders, acute renal insufficiency - measurement of GFR based on kinetics of renal inulin excretion. (muni.cz)
  • Cutaneous Radiation Injury (CRI) happens when exposure to a large dose of radiation causes injury to the skin. (cdc.gov)
  • The chance of survival decreases with increasing dose of radiation. (drugster.info)
  • The dose of radiation that is absorbed by the body is measured in gray (Gy). (epainassist.com)
  • The absorbed dose of radiation is measured in a unit called a gray (Gy). (pharmacypedia.org)
  • Diagnostic tests that use radiation, such as an X-ray, result in a small dose of radiation - typically well below 0.1 Gy, focused on a few organs or small amount of tissue. (pharmacypedia.org)
  • When a person has experienced known or probable exposure to a high dose of radiation from an accident or attack, medical personnel take a number of steps to determine the absorbed radiation dose. (pharmacypedia.org)
  • But certain death from a high dose of radiation may finally vanish with a stem cell-based cellular treatment that protects the human body when it is most defenseless. (livescience.com)
  • The amount of radiation that a person's body absorbs is called the radiation dose. (cdc.gov)
  • Acute Radiation Syndrome (ARS) is the medical term for the damage occurring to the body after exposure to large amount of radiation within a short period of time (24 hours). (epainassist.com)
  • The amount of damage and the type of damage to the body depends on the dose and amount of radiation absorbed by the body. (epainassist.com)
  • The amount of radiation absorbed in turn depends on the dose or the strength of the radiation and the distance between the source of radiation and the patient. (epainassist.com)
  • The diagnostic imaging tests such as an x-ray only use small amount of radiation, which is usually below 0.1 Gy and that too the radiation is focused on small amount of tissue or organs. (epainassist.com)
  • rad The U.S. unit used to measure absorbed radiation dose (the amount of radiation absorbed by an object or person). (epa.gov)
  • The amount of radiation absorbed by the body - the absorbed dose - determines how sick you'll be. (pharmacypedia.org)
  • The BfS says the maximum amount of radiation allowed from the DECT telephones by the International Commission for the Protection of Non-ionized Radiation is too high. (medindia.net)
  • Base stations and the handset send out the same amount of radiation during a telephone call regardless of the user's distance from the base station. (medindia.net)
  • Won't a tiny amount of radiation kill you? (dissidentvoice.org)
  • Depending on the mechanism of radiation, burns that appear immediately may be thermal rather than radiation injury, although complex mechanisms, not fully understood, are involved in radiation effects on the skin. (citizendium.org)
  • However, results of treatment of ARS remain limited and in cases of severe radiation injury insufficient. (radioprotection.org)
  • Primarily, external radiation is able to inflict acute health injury. (tidsskriftet.no)
  • Most of the cases involved local injury , such as radiation burns or hematopoietic cancer . (bvsalud.org)
  • When is the cell most susceptible to radiation injury? (studystack.com)
  • We found that 22 of the 59 cases had more than one blood count within the first 72 hours after the radiation exposure, a prerequisite for the triage injury classification method to be tested. (cdc.gov)
  • The risk of systemic infection is higher when the organism has a combined injury, such as a conventional blast, thermal burn, or radiation burn. (wikipedia.org)
  • Traditionally, the treatment of Acute Radiation Syndromes (ARS) includes supportive therapy, cytokine therapy, blood component transfusions and stem cell transplantation. (radioprotection.org)
  • Treatment of acute radiation syndrome consists of supportive therapy with blood transfusions, antibiotics to combat infection. (epainassist.com)
  • Treatment of acute radiation syndrome is generally supportive care . (mdwiki.org)
  • Treatment of acute radiation syndrome is generally supportive with blood transfusions and antibiotics , with some more aggressive treatments, such as bone marrow transfusions, being required in extreme cases. (gutenberg.org)
  • PSTI ), a leading developer of placenta-based cell therapy products, announced today the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome (ARS) at the American Society of Hematology's (ASH) 59th Annual Meeting to be held in Atlanta, Georgia, on December 9-12, 2017. (globenewswire.ca)
  • To date, the only three drugs approved by the U.S. Food and Drug Administration for treatment of acute radiation syndrome are growth factors targeting granulocyte (Neupogen ® or Neulasta ® ) or granulocyte and macrophage (Leukine ® ) hematopoietic cell lineages. (bioone.org)
  • Radiation Neurotoxin isolated from lymphatic system of irradiated animals (with a clinical picture of cerebral radiation syndrome) and injected to healthy animals in toxic doses 0.03 mg/kg, 0.5 mg/kg, 10.0 mg/kg, 15.0 mg/kg had initiated development of acute failure of blood circulation and breathing ventilation. (radioprotection.org)
  • Her research has spanned drug discovery, preclinical development, manufacturing and clinical development in indications such as acute radiation syndrome , inflammation, infectious disease, cancer and cancer supportive care. (freethesaurus.com)
  • Estimate a patient's absorbed radiation dose (i.e., level of radiation exposure) based on information from public health authorities, biodosimetry if available, or clinical findings such as time to onset of vomiting or lymphocyte depletion kinetics . (rxlist.com)
  • Clinical trials which have been conducted both in the United States, with the National Institute of Health and at Hadassah-University Medical Center in Jerusalem, have shown a nearly 100 percent recovery rate in animals exposed to radiation. (yahoo.com)
  • Yaky Yanay, President and Chief Operations Officer at Pluristem Therapeutics and co-chairman of Israel Advanced Technology Industries (IATI), said clinical trials have so far shown optimal results if the vial is injected within 48 hours of exposure to lethal radiation. (yahoo.com)
  • In: Ricks RC, Berger ME, O'Hara FM (eds) The medical basis for radiation accident preparedness: the clinical care of victims. (springer.com)
  • The initial focus of effort on the NIOSH ARS project, a component of Project 2.3, waS to add clinical information concerning the 59 accidentally radiation -exposed workers in the former Soviet Union during 1948 through 1958 to a similar number of accident cases collected in the Western world. (cdc.gov)
  • In view of the rarity of the syndrome, all 59 cases were prepared for further study in Project 2.3 A selection was therefore made of 77 clinical and laboratory items that were of most significance and likely to be on record in most cases. (cdc.gov)
  • The company's proprietary platform of toll-like immune receptor activators has applications in radiation mitigation, oncology immunotherapy, and vaccines. (yahoo.com)
  • Mice on flaxseed displayed improved survival rates and mitigation of radiation pneumonitis, with increased blood oxygenation levels, higher body weight, lower pro-inflammatory cytokine levels, and greatly reduced pulmonary inflammation and fibrosis. (medindia.net)
  • Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding. (iu.edu)
  • Absorbed and equivalent radiation doses can not be directly converted as the conversion depends on the type of radiation. (convert-me.com)
  • Understanding the type of radiation received, the way a person is exposed (external vs. internal), and for how long a person is exposed are all important in estimating health effects. (epa.gov)
  • They also try get more information about the exposure, such as what type of radiation it was, how far away you were from the source of the radiation, and how long you were exposed. (medlineplus.gov)
  • An acute illness caused by a dose greater than 50 rads of penetrating radiation to most or all of the body in a short time, usually a matter of minutes. (drugster.info)
  • People who receive a single large dose of 1,000 millisieverts of radiation to the total body can expect to experience acute radiation syndrome, characterized by changes in blood count, nausea, vomiting and diarrhea. (go.com)
  • It follows the format of the Syllabus in Radiation Biology prepared by the Radiological Society of North America (RSNA), and its content reflects the questions appearing in recent years in the written examination for diagnostic radiology residents given by the American Board of Radiology. (helsinki.fi)
  • The SNS developed recommendations to help health care professionals respond appropriately in the event of an attack involving radiation exposure. (annals.org)
  • Biological dosimetry is an essential tool for estimating radiation dose. (elsevier.com)
  • The sievert is a unit of dosage that is used to evaluate the biological effects of radiation. (go.com)
  • Conventional trauma and burns resulting from a bomb blast are complicated by the poor wound healing caused by hematopoietic syndrome, increasing mortality. (wikipedia.org)
  • Being exposed to a lot of radiation over a short period of time, such as from a radiation emergency , can cause skin burns . (medlineplus.gov)
  • Two employees of a company licensed by the U.S. Atomic Energy Commission to encapsulate sources for radiographic cameras received radiation burns after being exposed to 192 Ir powder. (wikipedia.org)
  • However, GM-CSF is not expressed in radiation injured tissue due to defervescence of the macrophages. (dovepress.com)
  • Each syndrome requires that the tissue showing the syndrome itself be exposed. (mdwiki.org)
  • Gamma radiation and x-rays are electromagnetic radiation (ie, photons) of very short wavelength that can penetrate deeply into tissue (many centimeters). (merckmanuals.com)
  • Procedure planning is an important part of radiation therapy in order to achieve optimal tumor reduction without damaging too much healthy tissue. (medgadget.com)
  • Antiradiation vaccine : immunoprophylaxis of acute radiation syndromes - radioprotective efficiency. (radioprotection.org)
  • There have been studies that kept track of large numbers of people who were exposed to radiation, including atomic bomb survivors and radiation industry workers. (epa.gov)
  • Exposure prevention is clearly possible in radiation -exposed workers . (bvsalud.org)
  • Another (interim) report carried out by the United Nation's scientific committee says that there was no association between the deaths of six workers at the plant during the accident and radiation exposure. (medicalnewstoday.com)
  • Even though a number of workers had had radiation exposure to their skin, no detectable health effects were present. (medicalnewstoday.com)
  • The main objective of the parent project, Joint Collaborative Committee for Radiation Effects Research (JCCRER) Project 2.3, is the development of a database of Mayak PA workers to use for such purposes as the verification of current dose-effect models for deterministic effects of acute exposure including the acute radiation syndrome or ARS. (cdc.gov)
  • The most famous incident is the " Radium Girls " of Orange, New Jersey where a large number of workers got radiation poisoning. (wikipedia.org)
  • News sources have said that the number of workers cycling through the damaged reactor has been increased from 50 to 100, and the Japanese Health Ministry raised the maximum radiation dose for the workers from 100 to 250 millisieverts (mSv). (livescience.com)
  • There are stationary radiation detectors throughout the plant, as well as portable radiation detectors that can be carried around by workers. (livescience.com)
  • Low-dose exposure to radiation, such as occurring during imaging tests like x-ray, MRI scan or CT scan do not cause acute radiation syndrome. (epainassist.com)
  • In order to maintain the macrophage's important role in host defense after radiation exposure, it is hypothesized that it is necessary to administer the drug exogenously in order to uphold the barrier against exogenous and endogenous infections and possibly prevent the potentially lethal systemic infection, which is the main cause of death in ARS. (dovepress.com)
  • A suspension of synthetic genistein nanoparticles was previously shown to be an effective radioprotectant against H-ARS when administered prior to exposure to a lethal dose of total body radiation. (indigobiosciences.com)
  • This level of radiation would be like getting the radiation from 18,000 chest x-rays distributed over your entire body in this short period. (epa.gov)
  • We've been investigating the placenta for the last decade and we have discovered that the placenta cells have unique properties that can help the body to recover after exposure to high level of radiation,' Lukasiewicz Hagai said. (yahoo.com)
  • It should be noted, however, that 250 mSv is not an unreasonable level of radiation . (livescience.com)
  • That's important in cases such as what's happening in Japan , where people may not learn the level [of radiation] they have been exposed to until 24 to 48 hours later. (livescience.com)
  • Barabanova AV (2002) Acute radiation syndrome with cutaneous syndrome. (springer.com)
  • Neutron or proton radiation produces many of the health effects described herein at lower absorbed dose levels. (cdc.gov)
  • The Biomedical Advanced Research and Development Authority (BARDA) exercised $6 million in additional contract options under its advanced research and development contract with Aeolus Pharmaceuticals for AEOL-10150, a broad-spectrum catalytic antioxidant specifically designed to neutralize reactive oxygen and nitrogen species, as a treatment for the pulmonary syndrome of acute radiation syndrome (Lung-ARS) and delayed effects of acute radiation exposure (DEARE). (genengnews.com)
  • This syndrome is the collection of bodily effects resulting from exposure to large amounts of radiation. (annals.org)
  • 5,000-10,000 millirem or 50-100 millisieverts) usually result in no harmful health effects, because radiation below these levels is a minor contributor to our overall cancer risk. (epa.gov)
  • A detailed account of radiation, its mode of action, side effects and dosage in the treatment of cancer. (medindia.net)
  • Flax used for weaving cloth, feeding people and animals, and even making paint could also protect healthy tissues and organs from the harmful effects of radiation, according to a new study. (medindia.net)
  • The victims of the atomic bombings either died immediately due to the detonation or later as a result of the acute or delayed effects of ionising radiation . (bfs.de)
  • The mean weighted colon dose (weighting: gamma colon dose + 10*neutron colon dose ) is used by the Radiation Effects Research Foundation (RERF) as a measure for the radiation exposure of the survivors. (bfs.de)
  • What are the long-term effects of radiation exposure? (health.com)
  • He reiterates throughout the show that radiation exposure-even at moderate or low levels-can have long-term effects on a person's health. (health.com)
  • Mettler FA, Moseley RD (1985) Carcinogenesis of specific sites and direct effects of radiation. (springer.com)
  • What are the health effects of radiation exposure? (medlineplus.gov)
  • A fetus is most vulnerable to the effects of radiation. (medlineplus.gov)
  • Experts agree that simple measures like creating a sealed containment in one's home and washing one's body and clothing has a direct impact on long-term and short-term effects of potential radiation exposure. (go.com)
  • Her death, at age 67, in 1934 was from aplastic anemia due to massive exposure to radiation in her work, [2] much of which was carried out in a shed with no proper safety measures being taken, as the damaging effects of hard radiation were not generally understood at that time. (wikipedia.org)
  • This would keep worker doses below the thresholds for health effects like acute radiation syndrome. (livescience.com)
  • Heritable Effects of Radiation 12. (helsinki.fi)
  • Effects of Radiation on the Embryo and Fetus 13. (helsinki.fi)
  • Among other things, apoptosis is largely responsible for the lethality of high-dose radiation exposure. (yahoo.com)
  • Subcutaneous wounding postirradiation reduces radiation lethality in mice. (iu.edu)
  • Radiation Toxins of Specific Radiation Deteminant group(neuro-toxic, neuro-vascular-toxic, entero-toxic, hemato-toxic) play an important role in development of Acute Radiation Syndromes and development of multi-organ involvement and multi-organ failure. (radioprotection.org)