Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Legislation, Food: Laws and regulations concerned with industrial processing and marketing of foods.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Job Application: Process of applying for employment. It includes written application for employment or personal appearance.Nuclear Warfare: Warfare involving the use of NUCLEAR WEAPONS.Acute Radiation Syndrome: A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.JapanRadioactive Hazard Release: Uncontrolled release of radioactive material from its containment. This either threatens to, or does, cause exposure to a radioactive hazard. Such an incident may occur accidentally or deliberately.Radiation Injuries, Experimental: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.Radiation Injuries: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.Foundations: Organizations established by endowments with provision for future maintenance.Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.Radiation-Protective Agents: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.Receptors, Granulocyte Colony-Stimulating Factor: Receptors that bind and internalize GRANULOCYTE COLONY-STIMULATING FACTOR. Their MW is believed to be 150 kD. These receptors are found mainly on a subset of myelomonocytic cells.Lethal Dose 50: The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.Radiodermatitis: A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Chimerism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Hematology: A subspecialty of internal medicine concerned with morphology, physiology, and pathology of the blood and blood-forming tissues.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Radiotherapy Planning, Computer-Assisted: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.X-Rays: Penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.

Expression of phospho-Elk-1 in rat gut after the whole body gamma irradiation. (1/35)

Gastrointestinal form is the second stage of acute radiation syndrome (ARS) with a threshold dose of 8 Gy in man. It represents an absolutely lethal clinical-pathological unit, necro-hemorrhagic enteritis and proctocolitis, with unknown causal therapy. Elk-1 is a protein acting as a transcription factor activating specified genes. The purpose of our study was to examine the expression of phospho-Elk-1 in irradiated jejunum and transversal colon of rats with radiation-induced enterocolitis and to assess the importance of this transcriptional factor as a biodosimetric marker of radiation-induced enteropathy. The laboratory rats were randomly divided into 21 groups, 10 animals per group, and irradiated with whole body gamma-irradiation of 1, 5, 10, 15, and 20 Gy. Samples of jejunum and transversal colon were taken 24, 48, 72, and 96 hours later, immunohisto-chemically stained, and the phospho-Elk-1 expression was examined using computer image analysis. A group of 10 sham-irradiated animals was used as control. Significantly increased expression of phospho-Elk-1 in rat jejunum has been found in all time intervals after irradiation by sublethal doses of 1 and 5 Gy, whereas after the irradiation by lethal doses, the expression of phospho-Elk-1 in rat jejunum varied considerably. Significantly increased expression of phospho-Elk-1 in transversal colon has also been found in the first days after irradiation by sublethal doses of 1 and 5 Gy. After irradiation by lethal doses, there was no uniform pattern of the changes in the expression of phospho-Elk-1 in rat transversal colon. The detection of phospho-Elk-1 might be considered as a suitable and very sensitive biodosimetric marker of radiation-induced injury of small and large intestine. According to our knowledge, this is the first study on the phospho-Elk-1 expression in irradiated jejunum and transversal colon in the rat.  (+info)

Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. (2/35)

Neurogenesis in the adult hippocampus, which occurs constitutively, is vulnerable to ionizing radiation. In the relatively low-dose exposure of acute radiation syndrome (ARS), the change in the adult hippocampal function is poorly understood. This study analyzed the changes in apoptotic cell death and neurogenesis in the DGs of hippocampi from adult ICR mice with single whole-body gamma-irradiation using the TUNEL method and immunohistochemical markers of neurogenesis, Ki-67 and doublecortin (DCX). In addition, the hippocampus-dependent learning and memory tasks after single whole-body gamma-irradiation were examined in order to evaluate the hippocampus-related behavioral dysfunction in the relatively low-dose exposure of ARS. The number of TUNEL-positive apoptotic nuclei in the dentate gyrus (DG) was increased 6-12 h after acute gamma-irradiation (a single dose of 0.5 to 4 Gy). In contrast, the number of Ki-67- and DCX-positive cells began to decrease significantly 6 h postirradiation, reaching its lowest level 24 h after irradiation. The level of Ki-67 and DCX immunoreactivity decreased in a dose-dependent manner within the range of irradiation applied (0-4 Gy). In passive avoidance and object recognition memory test, the mice trained 1 day after acute irradiation (2 Gy) showed significant memory deficits, compared with the sham controls. In conclusion, the pattern of the hippocampus-dependent memory dysfunction is consistent with the change in neurogenesis after acute irradiation. It is suggested that a relatively low dose of ARS in adult ICR mice is sufficiently detrimental to interrupt the functioning of the hippocampus, including learning and memory, possibly through the inhibition of neurogenesis.  (+info)

Dose estimation by chromosome aberration analysis and micronucleus assays in victims accidentally exposed to (60)Co radiation. (3/35)

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The radiation protection and therapy effects of mesenchymal stem cells in mice with acute radiation injury. (4/35)

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Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation. (5/35)

This study examined whether amifostine (WR-2721) could attenuate memory impairment and suppress hippocampal neurogenesis in adult mice with the relatively low-dose exposure of acute radiation syndrome (ARS). These were assessed using object recognition memory test, the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunohistochemical markers of neurogenesis [Ki-67 and doublecortin (DCX)]. Amifostine treatment (214 mg/kg, i.p.) prior to irradiation significantly attenuated the recognition memory defect in ARS, and markedly blocked the apoptotic death and decrease of Ki-67- and DCX-positive cells in ARS. Therefore, amifostine may attenuate recognition memory defect in a relatively low-dose exposure of ARS in adult mice, possibly by inhibiting a detrimental effect of irradiation on hippocampal neurogenesis.  (+info)

Radiation rescue: mesenchymal stromal cells protect from lethal irradiation. (6/35)

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Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation. (7/35)

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Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident. (8/35)

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*StemRad

Radiation belt a new line of defence in nuclear emergency Reuters.com "Acute Radiation Syndrome: Fact Sheet for Physicians". ... engineers who were first on the scene died from high doses of gamma radiation in an illness known as Acute Radiation Syndrome ( ... Existing shielding is therefore incapable of preventing the acute health effects of exposure to gamma radiation (i.e. Acute ... For the body to recover from the acute health effects of radiation, it is important to allow crucial biological regenerative ...

*Fukushima Daiichi nuclear disaster casualties

Despite this, there were no deaths caused by acute radiation syndrome. Given the uncertain health effects of low-dose radiation ... No radiation-related deaths or acute diseases have been observed among the workers and general public exposed to radiation from ... 12 April 2011 'Now radiation in Japan is as bad as radiation level is raised to 7 for only the second time in history' Daily ... among them that this figure was based on an assumption of acute deaths from low radiation doses. There is no known mechanism ...

*Mission critical

This can cause acute radiation syndrome to the people around the area. The mission critical is a business's quintessence and if ...

*Radiobiology

Examples are: radiation burns, acute radiation syndrome, chronic radiation syndrome, and radiation-induced thyroiditis. ... High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled ... but no cases of acute radiation syndrome), popularized the warnings of occupational health associated with radiation hazards. ... Eben Byers, a famous American socialite, died of multiple cancers (but not acute radiation syndrome) in 1932 after consuming ...

*List of civilian radiation accidents

Ten of the adults developed acute radiation syndrome. One exposed 60Co source was retrieved, but the source from the other ... Three weeks later, the worker suffered symptoms typical of acute radiation syndrome (vomiting, loss of hair, fatigue). One ... The thieves could have received a fatal dose of radiation. Background radiation International Nuclear Events Scale List of ... February 1, 2000 - Samut Prakan radiation accident: The radiation source of an expired teletherapy unit was purchased and ...

*Radiation-induced cancer

... whereas the same amount of acute external dose would invariably cause an earlier death by acute radiation syndrome. Internal ... Curie later died of acute radiation syndrome, not cancer. Eben Byers, a famous American socialite, died of multiple cancers in ... In addition to conventional fatalities and acute radiation syndrome fatalities, nine children died of thyroid cancer, and it is ... This contrasts with the deterministic effects of acute radiation syndrome which increase in severity with dose above a ...

*Committed dose

Intake of very large amounts of radioactive material can cause acute radiation syndrome (ARS) in rare instances. Examples ... In summary, not all radiation is harmful. The radiation can be absorbed through multiple pathways, varying due to the ... The radiation risk proposed by the International Commission on Radiological Protection (ICRP) predicts that an effective dose ... The most harmful way to absorb radiation is that of absorption because it is almost impossible to control how much will enter ...

*Nuclear Power and the Environment

List of books about nuclear issues Nuclear or Not? Environmental impact of nuclear power Acute Radiation Syndrome Flowers, Sir ... "Radiation: Alpha Particles". US Environmental Protection Agency. EPA. Retrieved 7 November 2014. "Radiation: Beta Particles". ... The focus of the first half of the chapter is designed to provide basic information about atoms and radiation to aid in later ... It begins by accepting that the hazards of ionizing radiation are well appreciated by anyone who works in the field and that ...

*Radiation poisoning (disambiguation)

Radiation poisoning may refer to Acute radiation syndrome, the short-term systemic health effects of a large radiation dose. ... including Radiation burns Radiation-induced cancer Radiation-induced lung injury Radiation-induced thyroiditis Radiation- ... Chronic radiation syndrome Electromagnetic hypersensitivity, the false belief that exposure to electromagnetic fields result in ... Eben Byers The action of neutron poisons that inhibit nuclear chain reactions Any of the negative health effects of radiation ...

*Effective dose (radiation)

High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled ... Ionizing radiation is generally harmful and potentially lethal to living things but can have health benefits in radiation ... but only the radiation type. Various body tissues react to ionising radiation in different ways, so the ICRP has assigned ... of low levels of ionising radiation. It takes into account the type of radiation and the nature of each organ or tissue being ...

*Pluristem Therapeutics

National Institutes of Health is currently evaluating Pluristem's PLX-R18 cells as a treatment for acute radiation syndrome. ... were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and ... "Mitigation of Lethal Radiation Syndrome in Mice by Intramuscular Injection of 3D Cultured Adherent Human Placental Stromal ... PLX-R18 can serve as a tool for governments to protect their citizens against potential exposure to nuclear radiation. The ...

*Maria Orbeli

During the process of her work she got sick with acute radiation syndrome, and some time after that she is dead. Maria Orbeli ...

*Brother in the Land

Ben becomes ill and dies of acute radiation syndrome: Danny and Kim bury him in the garden of an empty house. Inside the house ... In the months after the raid, all of the newly planted crops fail due to radiation damage. Kim's sister Maureen has become ... The narrative begins on a hillside, where the protagonist, Danny Lodge, encounters a man in a radiation suit, who confiscates ...

*Radioresistance

Radiation Damage and Dose Measurement". Retrieved 2006-05-13. "CDC Radiation Emergencies, Acute Radiation Syndrome: A Fact ... that protects against acute radiation syndrome, during radiotherapy. Radiosensitivity Background radiation Radiation hormesis ... Ionizing-radiation-resistant organisms (IRRO) were defined as organisms for which the dose of acute ionizing radiation (IR) ... Ex-Rad a radioprotective drug studied for its ability to protect against acute radiation syndrome CBLB502 a similar ...

*Cleveland BioLabs

... and development of products with the potential to treat cancer and protect against death following acute radiation syndrome. ... It is being developed both as a radiation countermeasure and as a cancer treatment. Entolimod is being developed and tested in ... Entolimod acts through activation of Toll-like Receptor 5 to mobilize antitumor immune response and reduce radiation effects on ... two contexts: as an anti-radiation pharmaceutical, under the U.S. Food and Drug Administration's Animal Efficacy Rule, without ...

*Radionuclide

Radiation exposure can produce effects ranging from skin redness and hair loss, to radiation burns and acute radiation syndrome ... EPA - Radionuclides - EPA's Radiation Protection Program: Information. FDA - Radionuclides - FDA's Radiation Protection Program ... In food preservation, radiation is used to stop the sprouting of root crops after harvesting, to kill parasites and pests, and ... This excess energy can be used in one of three ways: emitted from the nucleus as gamma radiation; transferred to one of its ...

*Roentgen equivalent man

The deterministic effects that can lead to acute radiation syndrome only occur in the case of high doses (> ~10 rad or > 0.1 Gy ... Doses greater than 100 rem received over a short time period are likely to cause acute radiation syndrome (ARS), possibly ... Office of Radiation and Indoor Air (May 2007). "Radiation: Risks and Realities" (PDF). Radiation: Risks and Realities. U.S. ... "How to Understand and Communicate Radiation Risk". Image Wisely. Retrieved 18 May 2012. Effects of ionizing radiation : UNSCEAR ...

*Alexander Akimov

Akimov died two weeks after the accident due to acute radiation syndrome, also known as radiation poisoning, at the age of 33. ...

*Nuclear-powered aircraft

... design problem was the need for heavy shielding to protect the crew and those on the ground from acute radiation syndrome; ... The main purpose of the flight phase was examining the effectiveness of the radiation shielding, which was one of the main ... In 1957, the Air Force and the U.S. Atomic Energy Commission contracted with the Lawrence Radiation Laboratory to study the ... Massive protection so reduced radiation levels that development could continue, but, as in the US, it ceased. The obvious ...

*Chernobyl Forum

... the report states that 28 emergency workers died from acute radiation syndrome and 15 patients died from thyroid cancer. It ... The report also concluded that a greater risk than the long-term effects of radiation exposure, is the risk to mental health ... United Nations Scientific Committee on the Effects of Atomic Radiation) the WHO (World Health Organization) the World Bank. The ... Since most emergency workers and people living in contaminated areas received relatively low radiation doses, comparable to ...

*Ex-Rad

Filgrastim ('Neupogen') a hematopoietic countermeasure of acute radiation syndrome (ARS). Pegfilgrastim ('Neulasta') longer ... "Radiation Protection by a New Chemical Entity, Ex-Rad: Efficacy and Mechanisms". Radiation Research. 171 (2): 173-9. doi: ... This newly developed compound is said to be a potent radiation protection agent.[citation needed] Chemically, it is the sodium ... Onconova suggests that Ex-Rad protects cells exposed to radiation against DNA damage, and that the drug's mechanism of action ...

*Huisheng Ai

"Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched ... "The radiation protection and therapy effects of mesenchymal stem cells in mice with acute radiation injury". The British ... Huisheng Ai (Chinese: 艾辉胜, born in 1958) is the current director of both the Hematology and Radiation Therapy Departments of ... After a short time working in various departments, he settled in the radiation and homeopathy departments, the most revered in ...

*Eben Byers

... not acute radiation syndrome. He is buried in Allegheny Cemetery in Pittsburgh, Pennsylvania, in a lead-lined coffin. Due to ... Stipp, David (June 9, 2003). "A Little Poison Can Be Good For You The received wisdom about toxins and radiation may be all wet ... His death on March 31, 1932, was attributed to "radiation poisoning" using the terminology of the time, but it was due to ... He earned notoriety in the early 1930s when he died from multiple radiation-induced cancers after consuming a popular patent ...

*Radiation-induced lung injury

"Time Phases of Acute Radiation Syndrome - Radiation Emergency Medical Management". www.remm.nlm.gov. U.S. Department of Health ... radiation fibrosis). Pulmonary radiation injury most commonly occurs as a result of radiation therapy administered to treat ... "Radiation-induced lung injury". Seminars in Radiation Oncology. 13 (3): 333-345. doi:10.1016/S1053-4296(03)00034-1. ISSN 1053- ... after exposure to 50 gray of radiation), in a few months. Radiation pneumonitis is characterized by: Loss of epithelial cells ...

*Environmental disaster

Some 50 emergency workers died of acute radiation syndrome, nine children died of thyroid cancer and an estimated total of 3940 ... An UNSCEAR report places the total confirmed deaths from radiation at 64 as of 2008. The eventual death toll could reach 4,000 ... died from radiation-induced cancer and leukemia. Hanford Nuclear, 1986 - The U.S. government declassifies 19,000 pages of ...

*Gastrointestinal disease

In the acute setting, this may be a cause of hepatic encephalopathy and hepatorenal syndrome. Other causes of chronic liver ... Inflammation of the rectum is known as proctitis, one cause of which is radiation damage associated with radiotherapy to other ... When symptoms occur, such as in acute pancreatitis, a person may suffer from acute-onset, severe mid-abdominal pain, nausea and ... Peutz-Jeghers syndrome can cause dark spots on the oral mucosa or on the lips or the skin around the mouth. Several GI diseases ...
Looking for online definition of acute radiation syndrome in the Medical Dictionary? acute radiation syndrome explanation free. What is acute radiation syndrome? Meaning of acute radiation syndrome medical term. What does acute radiation syndrome mean?
Synonyms for Acute radiation syndrome in Free Thesaurus. Antonyms for Acute radiation syndrome. 7 synonyms for syndrome: condition, complaint, illness, symptoms, disorder, ailment, affliction. What are synonyms for Acute radiation syndrome?
This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.
[212 Pages Report] Check for Discount on Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) - Pipeline Review, H2 2016 report by Global Markets Direct. Global Markets Directs, Radiation Toxicity (Radiation Sickness, Acute Radiation...
HAIFA, Israel, Dec. 07, 2017 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (NASDAQ:PSTI) (TASE:PSTI), a leading developer of placenta-based cell therapy products, announced today the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome (ARS) at the American Society of Hematologys (ASH) 59th Annual Meeting to be held in Atlanta, Georgia, on December 9-12, 2017.. The results of the study will be presented during Program Session 506: Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion, and Stromal Stem Cells. The poster, "Intramuscular Administration of Placenta-Derived Stromal Cells Enhances Survival of Rhesus Macaque Monkeys Exposed to Total Body Irradiation," will describe data from a recently announced Phase II-equivalent study under the U.S. Food and Drug Administration (FDA) Animal Rule. The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. This ...
Press Release issued Feb 5, 2014: Pluristem Therapeutics, Inc., a leading developer of placenta-based cell therapies, today announced that the U.S. National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health (NIH), will commence a mechanism-of-action study of Pluristems PLacental eXpanded RAD (PLX-RAD) cells for the treatment of acute radiation syndrome (ARS). The study aims to investigate the effect of PLX-RAD cells on body weight, blood count parameters, cytokine concentrations and bone marrow or spleen cellularity at various time points following the administration of PLX-RAD cells to animals receiving total body irradiation. The study is scheduled to begin in February 2014.
After irradiation with 2, 4, 7, or 12 Gy, changes in the bone marrow cells over time were examined through H&E staining and Ki-67 staining, a proliferation marker. In minipigs irradiated with 2 or 4 Gy, the myeloid hematopoietic cells disappeared drastically, starting at 30 minutes after irradiation; at the 17-hour point, only a minimal number of myeloid cells remained. On day 3 after irradiation, only some plasmacytoid cells and erythroblasts were observed; Ki-67 positive cells were hardly found (Figure 4A and B). For minipigs irradiated with 7 or 12 Gy, bone marrow tissues were obtained when they succumbed. In the histological analysis, we found that the bone marrow of these 2 minipigs was replaced with adipose cells, with a very small number of plasmacytoid myeloid cells. Moreover, few Ki-67 positive cells were found in the bone marrow (Figure 4C ...
Some may think that certain data are emphasized in this and other chapters in an attempt to minimize the dangers of exposure to radiation. This is not at all true. I am trying to put the dangers in perspective and eliminate the Pavlovian negative response to even the very mention of the subject. Table 8 shows the accepted syndrome from short-term exposures. Please note that this table is in rems (not millirems) and can be mentally converted to centisieverts (cSvs) of the same numerical value. Radiation can obviously be very dangerous. But so can an unreasonable fear of radiation ...
Sixteen Lewis (RT1l) rats were exposed to sublethal dose (7Gy) of Cs-137 TBI. Irradiated rats were divided into 4 experimental groups (n=4 each) based on therapeutic approach: Group 1 - no intervention; Group 2 - normal saline injection; Group 3 - allogeneic bone marrow transplantation (BMT) [ACI (RT1a)]; and Group 4 - DRCC transplantation [ACI/LEW (RT1a/RT1l]. Saline as well as cellular therapeutics were delivered into the femoral bone at 6 hours following TBI. DRCC were created by ex-vivo fusion of bone marrow cells derived from fully MHC mismatched LEW (RT1l) and ACI (RT1a) donors. Briefly, donor and recipient cells were isolated, separately stained with the PKH26 and PKH67 fluorescent dyes, fused with polyethylene glycol (PEG) and sorted by flow cytometry. Cells presenting double staining were transplanted in a dose 10-12 x 106. All animals received supportive treatment with prophylactic antibiotics, fluids, and softened food during 90-days follow-up. Blood samples were evaluated using ...
Author: A.I. Nyagu, K.N. Loganovsky, N.Yu. Chuprovskaya et al.. Reference: Український медичний часопис (Ukrainian Medical Magazine), 1997. Abstract: For detail contact the publisher:. Publisher: «МОРИОН». address: 02140, Kiev, prosp. Bazhana 10A. tel: 380(44)585-97-10. URL: http://www.umj.com.ua/. ...
Disaster Med Public Health Prep. 2011 Oct;5(3):202-12. doi: 10.1001/dmp.2011.68. Epub 2011 Oct 10. Research Support, Non-U.S. Govt; Review
Exposure to high doses of ionizing radiation in the event of therapeutic, accidental or intentional incident such as nuclear/radiological warfare can lead to debilitating injuries to multiple organs resulting in death within days depending on the amount of radiation dose and the quality of radiation. Unfortunately, there is not a single FDA-licensed drug approved against acute radiation injury.. Radiation damage to multiple organs often described as multiple organ dysfunction syndrome (MODS) or acute radiation syndrome (ARS) results from rapid depletion of radiosensitive cells, these cells are usually the stem or progenitor cells with high proliferative capacity; naturally, bone marrow stem cells (BMSC), and intestinal stem cells (ISC), which are extremely critical in maintaining a pool of peripheral blood cells and in maintaining villi for the absorption of nutrients are highly sensitive to radiation. One of the most efficient ways of rescuing MODS is to administer fresh cells that can repair, ...
Date: August 22, 2013. Company: BCN Biosciences, headquartered in Pasadena, Calif.. Cooperative agreement amount: BARDA will contribute $4 million over two years About the cooperative agreement: Through this cooperative agreement, BARDA will fund and collaborate on proof-of-concept studies by BCN Biosciences to determine how well a novel small molecule called Yel002, created by the company, protects DNA from damage after the bodys cells are exposed to damaging levels of radiation. This approach may increase the likelihood that cells in the gastrointestinal injury will survive exposure to acute radiation.. The GI tract is particularly sensitive to radiation but currently there is no treatment or preventive measure for this type of ionizing (damaging) radiation injury.. Acute Radiation Syndrome, also known as ARS, is a serious illness that occurs when all or most of the body receives a high dose of radiation, such as after the detonation of a nuclear device. ARS involves injuries to the bodys ...
Purpose: Discovery of agents that protect or mitigate normal tissue from radiation injury during radiotherapy, accidents, or terrorist attacks is of importance. Specifically, bone marrow insufficiency, with possible infection due to immunosuppression, can occur after total body irradiation (TBI) or regional irradiation and is a major component of the acute radiation syndrome. The purpose of this study was to identify novel radioprotectors and mitigators of the hematopoietic system.. Experimental Design: High-throughput screening of small-molecule libraries was done using viability of a murine lymphocyte line as a readout with further validation in human lymphoblastoid cells. The selected compounds were then tested for their ability to counter TBI lethality in mice.. Results: All of two major classes of antibiotics, tetracyclines and fluoroquinolones, which share a common planar ring moiety, were radioprotective. Furthermore, tetracycline protected murine hematopoietic stem/progenitor cell ...
Exposure to a moderate to high dose of ionizing radiation (IR) not only causes acute radiation syndrome but also induces long-term (LT) bone marrow (BM) injury. The latter effect of IR is primarily attributed to the induction of hematopoietic stem cell (HSC) senescence. Granulocyte colony-stimulating factor (G-CSF) is the only treatment recommended to be given to radiation victims soon after IR. However, clinical studies have shown that G-CSF used to treat the leukopenia induced by radiotherapy or chemotherapy in patients can cause sustained low white blood cell counts in peripheral blood. It has been suggested that this adverse effect is caused by HSC and hematopoietic progenitor cell (HPC) proliferation and differentiation stimulated by G-CSF, which impairs HSC self-renewal and may exhaust the BM capacity to exacerbate IR-induced LT-BM injury. C57BL/6 mice were exposed to 4 Gy γ-rays of total body irradiation (TBI) at a dose-rate of 1.08 Gy per minute, and the mice were treated with G-CSF (1 μg/each
Mass casualty scenarios of radiation exposure require high throughput biological dosimetry techniques for population triage, in order to rapidly identify individuals, who require clinical treatment. Accurate dose estimates can be made by biological dosimetry, to predict the acute radiation syndrome (ARS) within days after a radiation accident or a malicious act involving radiation. Timely information on dose is important for the medical management of acutely irradiated persons [1]. The aim of the study was to evaluate the usefulness of the micronuclei (MNi) scoring procedure in an experimental mode, where 500 binucleated cells were analyzed in different exposure dose ranges. Whole-body exposure was simulated in an in vitro experiment by irradiating whole blood collected from one healthy donor with 60 MeV protons and 250 keV X-rays, in the dose range of 0.3-4.0 Gy. For achieving meaningful results, sample scoring was performed by three independent persons, who followed guidelines described in ...
Radiation sickness, also known as acute radiation syndrome, varies with the amount of radiation an individual receives. The first signs of the disease usually are nausea and vomiting, which can be followed by fever, dizziness, weakness, bloody vomit and stools, difficulty breathing and infection. The bodys blood-making tissue, nervous system, digestive tract, lungs and cardiovascular system all can be affected. At very high doses, radiation is usually fatal.. Within the body, the effects of heavy radiation may include leakage of bacteria and the toxins they produce into the bloodstream from the digestive tract or through broken skin. Radiation effects wreak havoc with the function of the heart and lungs, disrupt the process of blood coagulation and inflame tissue throughout the body.. When bacteria or certain toxins enter the blood under normal conditions, the bodys immune system responds by dispatching neutrophils - white blood cells- - to destroy the intruders. The neutrophils release a ...
SIGNS AND SYMPTOMS/ /ACUTE RADIATION SYNDROME/ Fifty persons involved in the cesium-137 accident in Goiania showed symptoms of whole-body and local acute irradiation and also external or internal contamination mainly due to ingestion or absorption of cesium-137. Fourteen of the 50 developed severe bone marrow depression characterized by neutropenia and thrombocytopenia. Eight of these 14 received GM-CSF intravenously. None were submitted to bone marrow transplantation. Four of the 14 died due to hemorrhage and infection. For those with significant internal contamination evaluated by in-vitro and in-vivo assays, Prussian Blue was administered with doses ranging from 1.5 to 10 g/day. Besides Prussian Blue, other measures were taken to increase decorporation of cesium-137, including administration of diuretics, water overload, and ergometric exercises. From 50 to 100 persons are being followed in a medical protocol ...
HAIFA, Israel, July 18, 2013-- Pluristem Therapeutics Inc., a leading developer of placenta-based cell therapies, announced today that the U.S. National Institute of Allergy and Infectious Diseases, part of the U.S. National Institutes of Health, has recommended to Pluristem that NIAID expand the scope of its ongoing animal research using PLX-RAD cells for the treatment of acute radiation syndrome.
The study assessed the safety and efficacy of Pluristem Therapeutics PLX-R18 following intramuscular injection into irradiated and non-irradiated NHPs.
Dear Harry et al,. Even if people disagree, it makes it more pleasant for all of us who use this site on a regular basis if people can please civilly refrain from swearing at each other.. I do note that the blame the victim game is very prevalent around nuclear accidents and nuclear facilities. For example, students I had in the 90s who were from Ukraine said that the government had come up with a new syndrome, called "fear of radiation syndrome" which they used to denigrate people who were concerned about radioactive fallout from Chernobyl. Harrys comment is much the same. The government of Japan has not so far been telling the truth about the levels of radiation being released; there is no guarantee that their new scheme to finally tell the truth will be any closer to the truth. Blaming the victims - all those humans needlessly exposed to cell-damaging ionizing isotopes - does not advance not advance matters. It merely dismisses and denigrates humans who have very legitimate concerns about ...
Degenerative changes occur as soon as 30 minutes after exposure of 500-1000 rad. Initial effects are: impaired secretion of necessary fluids: cell breakdown results in failure of food and water absorption leading to infection and dehydration from diarrhea ...
Radiation doses exceeding a threshold of about 500 millisieverts (mSv) can cause tissue reactions in the human body, also called deterministic effects. They are the result of a massive cell killing and the subsequent loss of function of the affected organs or tissues.
Radiation doses exceeding a threshold of about 500 millisieverts (mSv) can cause tissue reactions in the human body, also called deterministic effects. They are the result of a massive cell killing and the subsequent loss of function of the affected organs or tissues. Particularly ...
NSWP is publishing the results of a global consultation exercise, carried out with our members in every region, and now written up into all the five languages of NSWP, for December 17th, International Day to End Violence Against Sex Workers.
The rationale for the use of the Animal Rule must be supported by proof-of-concept animal studies designed to ensure animal welfare, demonstrate relevance of the animal model (species susceptibility to the toxic agent and toxic response similar to humans), define the endpoint used to assess efficacy and predict human clinical benefit (eg, relief or prevention of adverse effects), ensure data quality and integrity in a contained environment, and be conducted under Good Laboratory Practice (GLP) guidelines. When efficacy is demonstrated in a single study, conducted in a sufficiently well‑characterized animal model, it may be necessary to repeat the study, preferably in another laboratory for confirmation. The investigational drug/biologic used in the adequate and well-controlled animal efficacy studies and in the animal pharmacokinetics and/or pharmacodynamics studies used to select a dose and dosing regimen in humans, ideally should be manufactured under current GMP regulations and be as close ...
Read Transcript, Download (.mov, 14MB). This final segment introduces the Clinical Decision Guide, a critical benchmark that can be used by clinicians in addition to other factors to help determine if medical countermeasures are indicated for a particular patient.. The Clinical Decision Guide (CDG) is an operational quantity that is specific to a type of radionuclide and a route of exposure (e.g. cesium-137 inhalational exposure). The CDG of children (0-18 yrs) and pregnant women is 20% that of adults.. For most radionuclides, the CDG is defined by the amount (activity) of radioactive material delivering an effective dose of 0.25 Sieverts (Sv) after incorporation into the body. This dose represents about a 1.3% lifetime risk of fatal cancer attributable to the exposure. Radiation measurements from a urine sample above a CDG value suggest the potential for a higher attributable lifetime fatal cancer risk and may help clinicians decide whether or not to start countermeasure treatment.. The CDG can ...
The National Institutes of Health recently posted a solicitation for the development of medical countermeasures to enhance platelet regeneration and survival following radiation exposure from a nuclear or radiological incident.
NAM and EATG, Europes community group for people with HIV, have launched a consensus statement, for endorsement by the HIV community, on using HIV treatment to prevent the transmission of HIV. ART drugs if taken as prescribed can effectively render people non-infectious. This treatment has not already ended the HIV epidemic for several reasons including lack of access to drugs, no global consensus on who should get them,.... ...
The premier source of breaking business news for the government contracting industry, GovCon Wire provides informative, to-the-point stories of the most significant contract awards, top-level executive moves, M&A activities and financial results of the sectors most notable players.. GovCon Wire is always on top of the most recent contracting sector activity and is updated in real time as the news breaks. ...
Illnesses collectively called acute radiation syndrome occur within a few hours to months after exposure to high-dose radiation (from approximately 1-2 Gy to 10 Gy). The principal signs and symptoms include vomiting within a few hours, followed within days to weeks by diarrhea, reduced blood cell counts, bleeding, hair loss (epilation), and temporary male sterility. Diarrhea results from damage to cells lining the intestines, reduction in blood cells from death of hematopoietic stem cells in bone marrow, and bleeding from declining blood platelets generated from such stem cells. Hair is lost due to damage to hair-root cells. Hairs do not fall out but rather become thinner and eventually break off. Sterility occurs in men from damage to sperm-generating stem cells ...
The possibility of an incident involving radiation exposure is at the forefront of public attention in the current global environment. With a greater number of entities possessing nuclear weapons and increased demand for nuclear power, the concern for uncontained exposure to radiation is increasing. In light of these developments, the need for treatments that may be easily stored and administered to large numbers of people who have been exposed to high doses of total body irradiation (TBI) is more urgent than ever before. Our goal was to identify and develop novel, drug-like small molecules that would exhibit radiomitigating activity for use in Acute Radiation Syndrome (ARS). Hot water extracts of Cats Claw containing quinic acid have been shown to possess activity in increasing circulating white blood cells as well as promoting DNA repair. Our group previously synthesized and evaluated a series of quinic acid derivatives. Quinic acid derivative KZ-41 was identified and described as highly water
HealthDay News) -- Once astronauts leave the Earths protective magnetic field, their cancer risk would soar while traveling to Mars, new research indicates.. Scientists said radiation exposure during a long-term deep-space mission would not only affect already damaged cells but also healthy ones nearby, doubling cancer risk.. Cosmic rays cause significant cell damage due from exposure to radiation, protons and heavy ions, the authors explained. Previous research has shown the health risks of deep space travel include cancer, cataracts, acute radiation syndromes, and problems with circulation and the central nervous system.. Typical risk models, including those used by NASA, assume radiation cancers are caused by DNA damage and mutations. These models, however, are based on much shorter times than a Mars mission would require, researchers noted.. Exploring Mars will require missions of 900 days or longer and includes more than one year in deep space where exposures to all energies of galactic ...
HealthDay News) -- Once astronauts leave the Earths protective magnetic field, their cancer risk would soar while traveling to Mars, new research indicates.. Scientists said radiation exposure during a long-term deep-space mission would not only affect already damaged cells but also healthy ones nearby, doubling cancer risk.. Cosmic rays cause significant cell damage due from exposure to radiation, protons and heavy ions, the authors explained. Previous research has shown the health risks of deep space travel include cancer, cataracts, acute radiation syndromes, and problems with circulation and the central nervous system.. Typical risk models, including those used by NASA, assume radiation cancers are caused by DNA damage and mutations. These models, however, are based on much shorter times than a Mars mission would require, researchers noted.. Exploring Mars will require missions of 900 days or longer and includes more than one year in deep space where exposures to all energies of galactic ...
Soligenix, Inc., a Princeton, N.J.-based biopharmaceutical company, announced on Sunday that the U.S. Food and Drug Administration reviewed and approved its investigational new drug application for its gastrointestinal acute radiation syndrome drug.
Purpose: Studies of the association between ataxia telangiectasia-mutated (ATM) gene polymorphisms and acute radiation injuries are often small in sample size, and the results are inconsistent. We conducted the first meta-analysis to provide a systematic review of published findings. Methods and Materials: Publications were identified by searching PubMed up to April 25, 2014. Primary meta-analysis was performed for all acute radiation injuries, and subgroup meta-analyses were based on clinical endpoint. The influence of sample size and radiation injury incidence on genetic effects was estimated in sensitivity analyses. Power calculations were also conducted. Results: The meta-analysis was conducted on the ATM polymorphism rs1801516, including 5 studies with 1588 participants. For all studies, the cut-off for differentiating cases from controls was grade 2 acute radiation injuries. The primary meta-analysis showed a significant association with overall acute radiation injuries (allelic model: ...
A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all of these mice, epilation and dry desquamation were induced, but bepotastine significantly reduced the extent of these areas. These results suggest that gamma irradiation-induced erythema and edema were caused by histamine released from mast cells via histamine H1 receptor, and epilation was induced by other inflammatory mediators ...
The purpose of the present study was twofold: (1) to determine if X-irradiation can be considered a direct stress agent, and if so, to what extent it differs from other stressors; and (2) to further elucidate the role of the adrenal cortex in the radiation syndrome by determining the more immediate responses of this system to X-irradiation.
While the concept of brain death is widely accepted, no universal criteria exist for its determination. This study compared guidelines from 80 countries finding that all standards specified exclusion of confounders, irreversible coma, absent motor response, and lack of brain-stem reflexes (see Wijdicks, "The Diagnosis of Brain Death" for more information). The majority of countries had medical practice standards (88%), legal standards (69%), utilized some form of apnea testing (59%), and required more than one physicians declaration (50%). Specifics varied widely on the qualifications of the physician, methods of apnea testing, and observation time before pronouncement of death. Regional differences were also noted, such as mandatory laboratory tests in Europe and Asia. Within the United States, brain death determination has been left to each state to decide (44 states and the District of Columbia have guidelines) whereas most African countries do not. Even if guidelines are not standardized, ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
In the present studies, we demonstrated that radiation induces an apoptotic response in the CNS at times and dose ranges relevant to acute radiation toxicity. After single-dose irradiation, there was evidence of ongoing apoptosis between 4 and 24 h after exposure, which peaked at 12 h. The peak incidence of apoptosis was 0.7-1.4% of the cells in spinal cord sections. These time frames and the incidence are consistent with the observation of Li et al. (11) , who showed in rat spinal cord that apoptosis occurred throughout the first 24 h after single-dose irradiation and peaked at 12 h at an incidence of 3%. Furthermore, that study also demonstrated that this level of ongoing apoptosis translated into an 18% loss of spinal cord cells by 24 h. This magnitude of apoptosis is likely to have functional consequences for the generation of radiation toxicity.. Our present studies also showed that 16-20% of the cells undergoing apoptosis were endothelial cells, whereas the rest involved glial ...
The next day Betty was so weak she could not move from the bed. When Betty was attended by doctors, she concealed, for fear of ridicule, her extraordinary sighting, making it difficult for physicians identify and target the source of their severe discomfort. But in the end they concluded that Ms. Cash was affected by acute radiation, which forced her to be hospitalized for several weeks. In addition, to check the physical impact of the event on Betty, it should be noted that days after the incident, the woman lost nearly half of the hair of the head and had different skin rashes, some the size of a large coin, which left permanent scars. In turn, Vickie and Colby had various skin problems and skin seemed defenseless against infections following the sighting. But perhaps the most serious injury suffered by Vickie has been to her eyes, as her vision was severely affected with the passage of time, in fact his eyes were watery and irritated for 3 months. Her eyelids were infected very quickly and ...
The threat of bioterrorism, long ignored and denied, has heightened over the past few years. Recent events in Iraq, Japan, and Russia cast an ominous shadow. Two candidate agents are of special concern: smallpox and anthrax. The magnitude of the problems and the gravity of the scenarios associated with release of these organisms have been vividly portrayed by two epidemics of smallpox in Europe during the 1970s and by an accidental release of aerosolized anthrax from a Russian bioweapons facility in 1979. Efforts in the United States to deal with possible incidents involving bioweapons in the civilian sector have only recently begun and have made only limited progress. Only with substantial additional resources at the federal, state, and local levels can a credible and meaningful response be mounted. For longer-term solutions, the medical community must educate both the public and policy makers about bioterrorism and build a global consensus condemning its use.
The expanded Center for Innovation in Advanced Development and Manufacturing (CIADM) in Baltimore helps the Nations pandemic preparedness.
The National Institute of Allergy and Infectious Diseases (NIAID), an institute within the NIH, is hoping to stave off the rise of the mutant zombies in th
CLT-008 is developed by the U.S. Food and Drug Administration Animal Rule for ARS. This approval pathway is available when human efficacy studies are neither ethical nor feasible and requires […]. ...
TOWNSEND: Well, the FDA Advisory Committee meets next week in this public hearing. Chimerix will be at it. If Chimerix can get their drug together, they can compete for it. They will look at the animal rule and the testing thats been -- thats gone on. And by the way, we talk about $433 million contract. If you look at the contract, you will see there are a number of milestones that the Siga as a company and the drug, SD-246, must meet in order to get payments along the way. This is not a guaranteed -- $433 million contract ...
A new $17 million research center dedicated to identifying medical countermeasures for neurotoxic chemicals that cause seizures in humans has been established by the U.S. National Institutes of Health at the University of California, Davis.
Lexapro and Migraine Headaches - Depression Home PageThis part of the. but I ciprofloxacin permanent side effects did increase my medication for that around.Classically acute radiation syndrome is divided into three main presentations:. very large skin doses can cause permanent hair loss, damaged sebaceous and sweat.. Pfenninger: Effects of menopause on hair By the Midland Daily News. was more hair loss over the entire body. permanent hair reduction.Inch Loss; Ultra Sound Cavitation; Cryo Lipo Fat Loss;. Diode Laser hair removal is one of the most comfortable procedures for permanent hair removal.. Melancholy, loss of energy, difficulty concentrating and suicidal thoughts. Permanent Vision. Loss. Lexapro in string position to become no. 1 brand in the ...
TY - JOUR. T1 - Kyoto global consensus report on Helicobacter pylori gastritis. AU - faculty members of Kyoto Global Consensus Conference. AU - Sugano, Kentaro. AU - Tack, Jan. AU - Kuipers, Ernst J.. AU - Graham, David Y.. AU - El-Omar, Emad M.. AU - Miura, Soichiro. AU - Haruma, Ken. AU - Asaka, Masahiro. AU - Uemura, Naomi. AU - Malfertheiner, Peter. AU - Azuma, Takeshi. AU - Bazzoli, Franco. AU - Chan, Francis Ka Leung. AU - Chen, Minhu. AU - Chiba, Naoki. AU - Chiba, Tsutomu. AU - Vas Coelho, Luiz Gonzaga. AU - Di Mario, Francesco. AU - Fock, Kwong Ming. AU - Fukuda, Yasuhiro. AU - Genta, Robert Maximilian. AU - Goh, Khean Lee. AU - Katelaris, Peter Harry. AU - Kato, Mototsugu. AU - Kawai, Takashi. AU - Kushima, Ryuji. AU - Mahachai, Varocha. AU - Matsuhisa, Takeshi. AU - Miwa, Hiroto. AU - Murakami, Kazunari. AU - OMorain, Colm Antoine. AU - Rugge, Massimo. AU - Sato, Kiichi. AU - Shimoyama, Tadashi. AU - Sugiyama, Toshiro. AU - Suzuki, Hidekazu. AU - Yagi, Kazuyoshi. AU - Wu, Ming ...
The purpose of this study was to investigate whether a relationship exists between alterations of the blood-brain barrier (BBB) and the survival time of rats exposed to supralethal irradiation. BBB alterations were produced by injection of glycerol, mercuric chloride, or by lymphatic cervical blockade. Animals were subsequently exposed to a supralethal dose of radiation, and the survival times of various groups were compared. The production of BBB alterations prior to irradiation did not influence the survival time of rats after exposure to supralethal doses of radiation suggesting that BBB damage may bear no direct relationship to the survival time after radiation injury. (Author)
Approval was granted by the Peter MacCallum Cancer Centre Institutional Ethics committee to conduct this retrospective study. Criteria for inclusion of patient data in the study included a pathological confirmation of NSCLC and treatment with concurrent chemotherapy and radical or high dose palliative radiotherapy at the Peter MacCallum Cancer Centre (East Melbourne campus). Exclusion criteria included previous thoracic RT, inconsistent radiation dose per fraction and hyper-fractionated radiation schedules. We also excluded patients with RT treatment interruptions ≥ 5 days, as mucosal recovery during the break may have confounded interpretation of the relationship between the oesophageal dose volume metrics and grade of oesophagitis.. Patient characteristics, treatment and toxicity data were extracted from paper and electronic medical records. Clinical data included the use of nasogastric (NG) or percutaneous endoscopic gastrostomy (PEG) tube, systemic steroids, proton pump inhibitors (PPI) ...
The availability of safe and effective radiation countermeasures for the military and civilian population represents a significant unmet medical need. To expedite the development of countermeasures for life-threating situations, the United States Food and Drug Administration (US FDA) has implemented the "Animal Rule" which applies to the development and evaluation of drugs and biologics to reduce or prevent life-threatening conditions caused by exposure to lethal or permanently disabling agents where human efficacy trials are neither feasible nor ethical. In addition, the FDA has introduced several incentives (fast track, orphan drug status, and emergency use authorization [EUA]) to attract drug sponsors to develop such agents for human use. Repurposing is vital to make drugs available for life-threatening conditions. Drugs are commonly repurposed for new indications not originally envisioned. By repurposing a drug, it can be made available for human use much quicker, but this pathway also ...
Cleveland BioLabs, Inc. is a clinical-stage biotechnology company leveraging deep mechanistic understanding of the cell death process, apoptosis, to develop a robust pipeline of compounds primarily focused on oncology applications and mitigation of radiation injury. The Companys lead compound is being developed as both a radiation countermeasure and a direct acting anticancer agent. The Company has two operating subsidiaries, Incuron, LLC, and Panacela Labs, Inc., and strategic relationships with the Cleveland Clinic, Roswell Park Cancer Institute, the Childrens Cancer Institute of Australia and the Armed Forces Radiobiology Research Institute. To learn more about Cleveland BioLabs, Inc., please visit the Companys website at http://www.cbiolabs.com ...
Whole Foods Magazine October 2012. Tocotrienols: Emerging Science and Innovations of Vitamin E. Part 4: A Review of Groundbreaking Tocotrienol Research. An Interview with Dr. Barrie Tan. By Richard A. Passwater, Ph.D.. For 90 years, vitamin E research has produced prolific and notable discoveries, including isolation from plants, chemical identifications and total syntheses. Until the last few decades, however, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, while more than one-third of all vitamin E tocotrienol research over the last 30 years was published in the last three years (2009 2011) (Figure 10). The thriving field of tocotrienol research gave ample ground for holding the 2nd International Tocotrienol Symposium (Long Beach, CA; April 29, 2012), where researchers presented their latest tocotrienol discoveries covering research areas that include cancer, skin health, radiation countermeasures, cognitive impairment, longevity and ...
Summary: Aim: to examine the therapeutic efficiency of melanin administered to mice after irradiation at lethal and sublethal doses. Material and methods: Survival and hematological states were studied on CD-1 mice receiving on acute or fractionated whole-body doses on X-rays or gamma-irradiation. Melanin soluble was given with water ad libitum from the first to the 30th-day after irradiation. Results. It was shown that melanin produced a significant therapeutic and protective-therapeutic action against acute radiation injury in the dose range 6,5-7,5 Gy (LD80-LD under our conditions). Cumulative survival melanin treated mice was increased to 14,4%, in control group - 1,9%. After fractionated injury (1 Gy daily, total dose 10 Gy) all mice which consumed melanin remained alive, versus 43,7% in control. Melanin decreased radiation-induced damage and stimulated the hematopoiesis recovery after sublethal exposure (5Gy). Conclusion. The results permit to regard melanin as a therapeutic agent for ...
Creating a scientifically semi-valid super-soldier, part 5: Heart and circulatory system. So youve designed a supercreature for those hard tasks in space. Whether its a miner, a soldier or something else, they are going to be prone to damage to themselves and their suit. Or you might have a police force that has to deal with a lunatic carrying a particle beam. "No biggie!" you think, "they are designed to take some damage!" Then after a little while the cancers start popping up all over their bodies and they die horrible deaths, or keel over on the spot from acute radiation poisoning.. Dont let that happen to you! Our scientists have found various ways (I hope) to build in radiation protection regardless of that radiation being from space, the scatter of radiation of a particle beam or just some emergency repairs of your local nuclear reactor.. The solutions would need to be buildable, maintainable and repairable by a biological creature. If you know a way you can build a metallic plastic or ...
500 mr/hr is definitely a high radiation area as defined. In U.S. plants 100 mr/hr and above gets roped off for cleanup and decontamination, but may lay around as puddles (from leaks) on the floor for days or weeks before that gets done.. In my day annual allowable accumulated dose at a U.S. facility was 5R, no more than 3R in any quarter. During a serious emergency - like a meltdown - that could go as high as 10R. Readily measurable blood changes and symptoms of acute radiation poisoning dont start until ~50-100 Rem, and LD50/30 is upwards of 350 Rem. This is of course acute exposure, there is no really safe long term exposure.. It would take this crew sitting still in the middle of the high-dose zone for 6 hours to get 3R of dose. Since they were just driving through, it is highly unlikely they encountered anything worth screaming about. Though a giant mutant glow-in-the-dark feral bull charging the vehicle would probably qualify… §;o). ...
This study will be a prospective double- blind trial. Patients with breast cancer with stages I-III undergoing to radiotherapy will be included. The participants will be allocated into an intervention group (laser therapy in 26 patients) or a control group ( in 26 patients the laser will be disabled without affecting its apparent function) , five days a week before radiotherapy . The low level laser therapy used in this trial will be Photon Lase III (DMC, approved by ANVISA for medicinal purposes). This InGaAIP laser emits a pulsed 660 nanometer beam with an average output of 80 milliwatts and the average energy density delivered to the breast will be 3 J/cm2. Skin reactions will be graded weekly by a nurse, by a radiotherapist and by an oncologist using the common toxicity criteria (CTC -developed by the National Cancer Institute ) and Acute Radiation Morbidity Scoring Criteria (developed by Radiation Therapy Oncology Group). The patients will answer the modified visual analogue scale for pain ...
The global consensus on anthropogenic global warming has been born out of decades of observation, testing, research, and peer-reviewed studies (many of the latter available to the general public). The consensus is all but universal, but many, including myself, do not find the margin of doubt sufficient to preserve the current trajectory for emitting carbon. Inaction (or subordinate action) includes the potential for instability of weather patterns, decrease in crop yields, elevated ocean levels, and loss of biodiversity. There may not be a consensus as to how severe these outcomes will be, but to ignore the risk would be irresponsible. ...
Battelle has again been chosen to protect our warfighters and the general public against dangerous infectious disease and chemical threats under a new contract
Achieving and integrating breakthroughs in all of these areas will require choreographed cooperation among researchers and engineers specializing in such areas as immunology, microbiology, virology, medical infectious diseases, molecular biology, and medical countermeasure product development and manufacturing. DARPA-funded teams will be required to demonstrate their integrated platforms in five simulations during the planned four-year program; they will initially test their platforms using pathogens of their choice, but ultimately they will test using DARPA-selected pathogens, including two demonstrations in which the identity of the pathogen will remain opaque to the teams until the 60-day clock starts. To ensure the developed platforms can produce a quality product with a viable pathway for regulatory review, each team will be required to complete a Phase I clinical safety trial before the end of the program. A benefit of the nucleic-acid-based approach to limiting the spread of infection is ...
X-ray catheterization is used to guide minimally invasive procedures including percutaneous coronary interventions (PCIs), involving diffuse and multiple vessel disease and total chronic occlusion as well as electrophysiology (EP) procedures. While the medical benefit to patients outweighs the procedural risk, long fluoroscopy times associated with complex interventions have resulted in acute radiation injuries to patients. Radiation induced cancers have also become a concern in younger patient populations. With the increased number, diversity and complexity of the interventions performed, there has been a growing interest in reducing the long-term exposure risk to medical personnel (interventionists).. Conventional methods to reduce in radiation exposure, however, impact and often degrade diagnostic image quality. Catheterization procedures focus on a small portion of the anatomy forming the central region of the image with the periphery providing contextual information. Thus, decreasing the ...
While lowering the top reflector, Slotins screwdriver slipped a fraction of an inch, allowing the top reflector to fall into place around the core. Instantly there was a flash of blue light and a wave of heat across Slotins skin; the core had become supercritical, releasing a massive burst of neutron radiation. He quickly knocked the two halves apart, stopping the chain reaction and likely saving the lives of the other men in the laboratory. Slotins body positioning over the apparatus also shielded the others from much of the neutron radiation. He received a massively lethal dose in under a second and died nine days later from acute radiation poisoning. The nearest physicist to Slotin, Alvin C. Graves, was watching over Slotins shoulder and was thus partially shielded by him, receiving a high but non-lethal radiation dose. Graves was hospitalized for several weeks with severe radiation poisoning, developed chronic neurological and vision problems as a result of the exposure, suffered a ...
Assessments of diseases are usually performed by a combination of clinical symptoms, signs and objective measurements. Biochemical markers of inflammation are important in evaluation of treatment of acute and chronic diseases. In this thesis we have focused on two inflammatory diseases: acute radiation proctitis and rheumatoid arthritis. We examined established and new biomarkers, with focus on two closely related proteins, calprotectin (S100A8/S100A9) and S100A12 (ENRAGE). These and other biomarkers were compared to clinical symptoms and signs with the aim of defining their usefulness in monitoring the course of the diseases. Characterizing the changes induced by radiation therapy to the pelvic region showed incongruent time profiles in symptoms, histological scoring of inflammation and biochemical measurements. Compared to the examination before start of radiation therapy, biopsies from rectal mucosa showed a maximal inflammation at the first examination during radiation therapy, while ...
title:Continious Hyperfractionated Accelerated Radiation Therapy in Head and Neck Cancers - A Pilot Study. Author:Thejaswini B, R. Nanda, Jagannath P, Giri G V, Aradhana K. Keywords:CHART, accelerated hyperfractionation, acute toxicities, head and neck cancers. Type:Original Article. Abstract:Objectives: To assess the acute radiation reactions and immediate locoregional response of accelerated hyperfractionation radiotherapy in head and neck cancers. Methods: A prospective study of 20 patients with squamous cell carcinoma of oropharynx, hypopharynx and nasopharynx with stage II - IV received continuous accelerated hyperfractionated radiotherapy (CHART) to a total dose of 54 Gy/36 fractions, dose per fraction of 1.5GY/fraction, 3 fractions /day given at 4-6 hours interval, 6 days / week with overall treatment time of 12 days. Results: Patients were assessed as per UICC guidelines. 6 patients developed Grade 6 mucositis, 10 patients developed Gr 5 mucositis and remaining 4 patients developed only ...
Acute Enteritis, in most cases is defined as a condition of inflammation of the small intestine as a result of eating and drinking contaminated water and foods infected by virus and bacteria. But according to the study by the University Hospital Aintree, chronic radiation enteritis is an increasing problem, as more patients receive radiotherapy as part of their cancer therapy and as the long-term survival of these patients improves(a). Other study indicated that acute radiation enteritis is almost inevitable in the curative treatment of malignant tumors of the abdomen and pelvic area. It is frequently a self-limiting disorder of intestinal function associated with reversible mucosal changes of the intestine(b). The prevalence of the disease although is decreasing, it still affects millions (approx 1 in 83 or 1.20% or 3.3 million people in USA ) of people in the U.S alone, according to the statistic. Chronic enteritis is a condition of inflammation caused by other health conditions, such as ...
Reducing carbon dioxide (CO2) emissions has become a global consensus in response to global warming and climate change, especially to China, the largest CO2 emitter in the world. Most studies have focused on CO2 emissions from the production sector, however, the household sector plays an important role in the total energy-related CO2 emissions. This study formulates an integrated model based on logarithmic mean Divisia index methodology and a system dynamics model to dynamically simulate household energy consumption and CO2 emissions under different conditions. Results show the following: (1) the integrated model performs well in calculating the contribution of influencing factors on household CO2 emissions and analyzing the options for CO2 emission mitigation; (2) the increase in income is the dominant driving force of household CO2 emissions, and as a result of the improved standard of living in China a sustained increase in household CO2 emissions can be expected; (3) with decreasing energy intensity
The CLD Workshop took 18 months to complete and involved 79 experts from around the world. "Workshop participants used an evidence-based approach and a process of open communication, dialogue, and transparency in order to achieve a global consensus concerning multiple aspects of CLD," noted Mark Willcox, PhD, FBCLA, FAAO, MASM, Professor, School of Optometry & Vision Science, University of New South Wales, and Vice-Chair of the Workshop. "This TFOS report will significantly increase awareness of factors that may, and may not, contribute to the generation of CLD. Ideally, this TFOS report will stimulate innovative research in this very important field," commented David A. Sullivan, MS, PhD, FARVO, Founder and recent past TFOS President, Senior Scientist, Schepens Eye Research Institute/Harvard Medical School and Organizer of the TFOS CLD Workshop. ...
Linear polyethylenimines (PEIs) contain all secondary amines, in contrast to branched PEIs which contain primary, secondary and tertiary amino groups.
124444-83-3 - ATTSGZBXNWVPJF-UHFFFAOYSA-N - Piperazine, 1-(3-pyridinylcarbonyl)-4-(2-(trifluoromethyl)phenyl)-, monohydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Purpose: It was recently reported that the organic arsenic compound darinaparsin (DPS) is a cytotoxin and radiosensitizer of tumor cells in vitro and in subcutaneous xenograft tumors. Surprisingly, it was also found that DPS protects normal intestinal crypt epithelial cells (CECs) from clonogenic death after ionizing radiation (IR). Here we tested the DPS radiosensitizing effect in a clinically relevant model of prostate cancer and explored the radioprotective effect and mechanism of DPS on CECs. Methods and Materials: The radiation modification effect of DPS was tested in a mouse model of orthotopic xenograft prostate cancer and of IR-induced acute gastrointestinal syndrome. The effect of DPS on CEC DNA damage and DNA damage responses was determined by immunohistochemistry. Results: In the mouse model of IR-induced gastrointestinal syndrome, DPS treatment before IR accelerated recovery from body weight loss and increased animal survival. DPS decreased post-IR DNA damage and cell death, ...
There is no known effective treatment for cats and dogs with nodular and diffuse liver tumors as liver tumors are generally considered resistant to chemotherapy and radiation therapy. However, three-dimensional conformal radiation therapy has been reported with objective responses in five of six dogs and minimal acute radiation effects; and the use of adjuvant gemcitabine in dogs with incompletely excised massive HCC, nodular HCC, and diffuse HCC has been reported in 18 dogs with good results.. Palliative treatment options, especially for nodular and diffuse hepatic tumors, include, microwave ablation, embolization, and chemoembolization, but these modalities are not widely available.. PROGNOSIS. The prognosis following surgical resection of massive HCC in dogs and bile duct adenomas in cats is very good. The majority of cats and dogs are cured. In one study of 42 dogs with massive HCC treated with liver lobectomy, two dogs (5%) died intraoperatively secondary to blood loss as a result of ...
After 35 years manned space exploration of the Moon and Mars is back on the agenda. With it comes the far greater concern for the health risks to astronauts due to Space Weather events causing acute radiation sickness and/or death. The probability is very high that a significant Solar Proton Event will envelope a space craft on these longer missions.. Several innovative Active Shield mitigation solutions, reminiscent of Star Trek "deflector shields", have being proposed along with material shielding and biochemical protection[1].The work presented here concerns recent modelling and laboratory experiments done on the artificial or mini-magnetosphere concept.. The idea, first seriously considered in the 1960s, is to put a portable artificial magnetosphere around the space craft to create a magnetically confined plasma barrier, not unlike an in-side out tokamak. This solution imitates the terrestrial magnetosphere, it deflects or buffers much of the worst effects of SEPs and prevents otherwise ...
In the 1979 movie The China Syndrome, reporter Kimberly Wells (played by Jane Fonda) witnesses an accident at a nuclear power plant and then uncovers a plot to keep it a secret in order to protect the power companys billion-dollar investment. The film was a gift to the political left, which at the time opposed the pursuit of nuclear energy to reduce our addiction to foreign oil. In some liberal circles, that opposition remains strong.. The film, along with real-life accidents such as Three Mile Island (also in 1979), in which no one was killed, and Chernobyl (1986), which, according to the World Nuclear Association, killed two Chernobyl plant workers on the night of the accident, and a further 28 people within a few weeks, as a result of acute radiation poisoning, account for much of our modern thinking about all things nuclear. Other films, like Dr. Strangelove, Fail-Safe and On the Beach -- along with the bombing of Hiroshima and Nagasaki, which ended World War II and launched the ...
There is no global consensus on recommended maximum intake (or safe limits) of the drug alcohol (also known formally as ethanol). The guidelines provided by health agencies of governments are varied and are shown below. These recommendations concerning maximum intake are distinct from any legal restrictions (e.g. driving after consuming alcohol) that may apply in those countries. The American Heart Association recommends that those who do not already consume alcoholic beverages should not start doing so because of the negative long-term effects of alcohol consumption. The recommended limits for daily or weekly consumption provided in the various countries guidelines generally apply to the average healthy adult. However, many guidelines also set out numerous conditions under which alcohol intake should be further restricted or eliminated. They may stipulate that, among other things, people with liver, kidney, or other chronic disease, cancer risk factors, smaller body size, young or advanced ...
(CIDRAP News) - A new report from the US Department of Health and Human Services (HHS) offers a few predictions on when certain new countermeasures against biological threats will become available, including a forecast for two novel influenza drugs and possibly a next-generation anthrax vaccine within the next 5 years.
A reader tipped us off to this fire hydrant on the corner of Gottingen and Falkland, which has been recently repainted a delightful bright orange-unfortunately, some of the surrounding sidewalk also got sprayed. Orange sidewalks? In your dreams, hippie.
Purified MiniPig Kidney Lysate, Total Protein from Creative Biomart. MiniPig Kidney Lysate, Total Protein can be used for research.
Global Markets Direct\s, \Radiation Injury - Pipeline Review, H1 2015\ on RnRMarketResearch.com the Report provides an overview of the Radiation Injury\s therapeutic pipeline. Slideshow 7182405 by rudra777
At the Fukushima nuclear plant affected by the recent earthquake in Japan, workers have been attempting to fix the damage to the reactors, despite potentially high levels of radioactive contamination. As a result, the workers may now be invited to bank their stem cells for future treatment should they become ill.. High levels of radiation exposure may cause illness from radiation syndrome - destruction of the bone marrow, skin, gastrointestinal tract and lungs - which may lead to death. Survival rates of sufferers decrease with increasing intensity of radiation. Japanese authorities are proposing harvesting blood stem cells from the workers should they fall ill and require stem cell transplants later. The procedure is currently used for some cancer patients whose bone marrow has been destroyed following extensive chemo- or radiation therapies. Patients take drugs to increase the release of blood stem cells from the bone marrow, which are later harvested from the blood and stored. According to ...
The H5N1 avian influenza virus is firmly established among animals in Asia and has begun to extend its reach into Europe. From 7-9 November, more than 400 animal and human health experts, senior policy makers, economists and industry representatives will gather in Geneva to work towards a global consensus to control the virus in domestic animals and prepare for a potential human influenza pandemic. The disease in animals caused by the H5N1 influenza virus has resulted in the culling of at least 150 million birds in the last two years. H5N1 remains for the moment an animal disease, but the World Health Organization (WHO) has warned that H5N1 is a virus that has the potential to ignite a human influenza pandemic. While no one can predict the timing or severity of the next influenza pandemic, governments around the world are taking the threat seriously. A series of international meetings held over the last ten weeks will culminate in the Geneva meeting. The meeting is co-organized by WHO, the Food ...
efoods]"This policy would seek to: (1) mitigate illness and prevent death; (2) sustain critical infrastructure; and (3) complement and supplement State, local, territorial, and tribal government medical countermeasure distribution capacity," the order said. "The US Postal Service has the capacity for rapid residential delivery of medical countermeasures for self administration across all communities in the United States," the order added. The US Health and Human Services Secretary Kathleen Sebelius and Homeland Security Secretary Janet Napolitano were instructed to work with the post office to develop a "dispensing model for US cities to respond to a large-scale biological attack, with anthrax as the primary threat consideration." The order calls for the model to be drawn up within 180 days, but gives no details as to whether the idea of using the US postal system to assist Americans in the wake of a biological attack is a new one. The United States has sought to bolster its capacity to respond ...
Kevin Coulston is raising funds for A Fowl American {Political Parody Cartoon} on Kickstarter! Humanity has been wiped out. Animals rule the earth this time around. Under President Rump, history seems to be repeating itself. Sad.
Current Counter Mind & Body Control & Counter EMF Harassment Recommendations * Please note much of the information posted below is based on purely logical and mathematical speculations and have not been proven or tested to be safe or valid...
Radiation proctitis (and the related radiation colitis) is inflammation and damage to the lower parts of the colon after exposure to x-rays or other ionizing radiation as a part of radiation therapy. Radiation proctitis most commonly occurs after treatment for cancers such as cervical cancer, prostate cancer, and colon cancer. Radiation proctitis involves the lower intestine, primarily the sigmoid colon and the rectum and is part of the conditions known as pelvic radiation disease and radiation enteropathy. Radiation proctitis can occur at two times after treatment: Acute radiation proctitis - symptoms occur in the first few weeks after therapy. These symptoms include diarrhea and the urgent need to defecate, often with pain while doing so (tenesmus). Acute radiation proctitis usually resolves without treatment after several months, but symptoms may improve with butyrate enemas. This acute phase is due to direct damage of the lining (epithelium) of the colon. Chronic radiation proctitis - is a ...
Definition of ionizing radiation injury in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is ionizing radiation injury? Meaning of ionizing radiation injury as a legal term. What does ionizing radiation injury mean in law?
The desire to develop and evaluate drugs as potential countermeasures for biological and chemical threats requires test systems that can also substitute for the clinical trials normally crucial for drug development. Animal models have limited predict
The Transformational Medical Technologies (TMT) has been a unique component of the U.S. Department of Defense (DoD) medical biodefense efforts since 2006. Its mission is to advance countermeasure research and development in support of the broader goal of the DoD to protect warfighters from emerging infectious diseases and future genetically engineered biological weapons. The TMT, using advanced science and technology approaches, focused on the development of roadspectrum countermeasures that target common host and pathogen pathways or enhance the hosts immune response. Many of these pathogens are lethal or cause such debilitating diseases in humans that it is ethically inappropriate to test the efficacy of these countermeasures in human volunteers. In lieu of human participants, these products may be tested in animals and approved for human use under the provisions of the Food and Drug Administration (FDA)s 2002 Animal Rule. The reliance on animal models for the development and licensure of ...
Malabsorption syndrome is a common gastrointestinal syndrome,in which the body fails to absorb essential constituents of food. The defect lies in the gastrointestinal tract which is the main source where all of the important constituents of food is absorbed. Malabsorption syndrome is characterised by malnutrition,chronic diarrhea and steatorrhea.. ETIOLOGY:. ...
HealthDay Reporter. (HealthDay News) -- When it comes to stomach discomfort during exercise, forget that old adage no pain, no gain. New research suggests that excessive strenuous exercise may lead to gut damage.. The stress response of prolonged vigorous exercise shuts down gut function, said lead author Ricardo Costa.. The redistribution of blood flow away from the gut and towards working muscles creates gut cell injury that may lead to cell death, leaky gut, and systemic immune responses due to intestinal bacteria entering general circulation, Costa added. Hes a senior researcher with the department of nutrition, dietetics and food at Monash University in Australia.. Researchers observed that the risk of gut injury and impaired function seems to increase along with the intensity and duration of exercise.. The problem is dubbed exercise-induced gastrointestinal syndrome. The researchers reviewed eight previously done studies that looked at this issue.. Two hours appears to be the ...
The objective of this FOA is to continue a program of multi-project translational research Centers focused on advancing discovery, preclinical development, production, licensure and/or use of new or improved countermeasures (therapeutics, immunotherapeutics, vaccines, vaccine technologies, and medical diagnostics) or related technologies specific to select NIAID Emerging Infectious Diseases/Pathogens. NIAID encourages Centers focused on development of medical countermeasures that are effective against a variety of pathogens and toxins, technologies that can be widely applied to improve classes of products, and platforms that can reduce the time and cost of creating new products. Each Center will be organized around a Center-selected theme (Center theme) that addresses development and/or use of a targeted countermeasure or technology. NIAID anticipates considerable variety among Center themes and objectives, which can range from the development of single or multiple countermeasures targeting a ...
Laboratory animal models have been widely used for vaccine research and development. According to the Animal Efficacy Rule (also known as the "two animal rule") instituted by the USA Department of Health and Human Services (HHS) and Food and Drug Administration (FDA), development and approval of human therapeutics (e.g., vaccines) requires demonstration of a reasonably well-understood mechanism and that at least two different animal species be used to demonstrate response[s] predictive for humans. Vaxar is a VIOLIN program that focuses on investigation of vaccine-induced animal responses. To use Vaxar, you can start to select pathogens and items you wish to compare below:. ...
Wall Street Journal The scenario laid out by the movie "Contagion," about an outbreak of a new virus, was scary enough.. But while "naturally occurring disease remains a serious threat, a thinking enemy armed with these same pathogens, or with multi-drug-resistant or synthetically engineered pathogens could produce catastrophic consequences.". So says a new report from the Bipartisan WMD Terrorism Research Center that finds the U.S. woefully unprepared to deal with many aspects of different bioterrorism scenarios. The WMD Center is a not-for-profit research and education organization.. It urges the government to focus on improving its ability to detect and deal with large-scale events, both of contagious and non-contagious pathogens. Specifically, it recommends focusing on aspects of the response that now earn a "D" grade: detection and diagnosis; improving the development, approval, availability and dispensing of medical countermeasures; and improving the capability to medically manage an ...
ANNAPOLIS, Md., Jan. 14, 2013 /PRNewswire/ -- PharmAthene, Inc. (NYSE MKT: PIP), a biodefense company developing medical countermeasures against biological and chemical threats, announced today that it has entered into an exclusive commercial license for the use of Percivias proprietary PER.C6® technology platform in the production of PharmAthenes next generation recombinant butyrylcholinesterase (rBChE) bioscavenger. The PER.C6® platform is a human, cell-based manufacturing system that enables the production of high quality, cost effective biological products for the life sciences industry with the added benefit of being fully human, unlike products manufactured using other expression systems. "The PER.C6® platform offers many advantages over our initial transgenic approach, which successfully completed a Phase I clinical study. These include, the opportunity for higher production yields with substantially reduced production costs and the capability for rapid scale up in the event of a ...
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They display a characteristic ruffled border where proteases and acid are secreted, allowing for bone resorption and formation of resorption pits in the bone surface [25]. Osteoclast morphology varies between mammals and teleosts (bony fishes), and also between different groups of teleosts [20]. In the skeleton of young zebrafish for example, osteoclast activity is carried out by both mononucleated and multinucleated cells [26]. In fact, there is an ontogenetic progression from mono- towards multinucleated osteoclasts. In juvenile zebrafish, bone resorbing cells in the developing lower jaw are. at first mononucleated. In thin skeletal tissues such as the neural arch, mononucleated cells are even predominant in adults [26]. In rainbow trout, scale resorption Selleck BIBF1120 PD0325901 is predominantly carried out by mononucleated osteoclasts [27]. Although in mammals these mononucleated cells are often just regarded as osteoclast precursors, in fish mononucleated osteoclasts are active bone ...
About Soligenix, Inc.. Soligenix is a clinical stage biopharmaceutical company focused on developing products to treat serious inflammatory diseases where there remains an unmet medical need, as well as developing several biodefense vaccines and therapeutics. Soligenix is developing proprietary formulations of oral BDP (beclomethasone 17,21-dipropionate) for the prevention/treatment of gastrointestinal disorders characterized by severe inflammation, including pediatric Crohns disease (SGX203), acute radiation enteritis (SGX201) and chronic Graft-versus-Host disease (orBec®), as well as developing its novel innate defense regulator (IDR) technology SGX942 for the treatment of oral mucositis. Through its BioDefense Division, Soligenix is developing countermeasures pursuant to the Biomedical Advanced Research and Development Authority (BARDA) Strategic Plan of 2011-2016 for inclusion in the US governments Strategic National Stockpile. Soligenixs biodefense products in development are a ...
Durham, NC based biopharmaceutical company, Chimerix announced yesterday that its investigational antiviral brincidofovir showed a survival benefit in a pivotal study of an animal model for smallpox.. Chimerix is developing brincidofovir as a medical countermeasure against smallpox, for which there is no antiviral agent currently approved. Brincidofovir has demonstrated broad-spectrum in vitro activity across five families of DNA viruses, and in addition to smallpox, is also being studied in two Phase 3 clinical trials for prevention of cytomegalovirus (CMV) and treatment of adenovirus infections in immunocompromised patients. The U.S. Food and Drug Administration (FDA) has granted Fast Track status to brincidofovir for smallpox, CMV, and adenovirus.. The pivotal smallpox study was conducted under the FDAs Animal Efficacy Rule, which allows for testing of investigational compounds in animal models to support the drugs effectiveness in diseases which are not ethical or feasible to study in ...

Acute radiation syndrome synonyms, Acute radiation syndrome antonyms - FreeThesaurus.comAcute radiation syndrome synonyms, Acute radiation syndrome antonyms - FreeThesaurus.com

Antonyms for Acute radiation syndrome. 7 synonyms for syndrome: condition, complaint, illness, symptoms, disorder, ailment, ... Synonyms for Acute radiation syndrome in Free Thesaurus. ... Acute radiation syndrome synonyms, Acute radiation syndrome ... "Pulmonary Acute Radiation Syndrome" or "Lung-ARS") as well as the gastrointestinal sub-syndrome of acute radiation syndrome (" ... syndrome. (redirected from Acute radiation syndrome). Also found in: Dictionary, Medical, Acronyms, Encyclopedia, Wikipedia. # ...
more infohttps://www.freethesaurus.com/Acute+radiation+syndrome

The Acute Radiation Syndrome | The BMJThe Acute Radiation Syndrome | The BMJ

The Acute Radiation Syndrome. Br Med J 1952; 2 doi: https://doi.org/10.1136/bmj.2.4790.925 (Published 25 October 1952) Cite ...
more infohttp://www.bmj.com/content/2/4790/925

Acute radiation syndrome - encyclopedia article - CitizendiumAcute radiation syndrome - encyclopedia article - Citizendium

Acute radiation syndrome (ARS), also called radiation sickness, is the result caused by receiving a dose greater than 75 rads ( ... Acute Radiation Syndrome: A Fact Sheet for Physicians. *↑ 3.0 3.1 3.2 3.3 Waselenko,JK et al. (15 June 2004), "Medical ... Other radiation syndromes can be caused by localized radiation, or a cumulative whole-body exposure over a length of time (e.g ... Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group", ...
more infohttp://en.citizendium.org/wiki/Acute_radiation_syndrome

Death. Conversion Chart /
Radiation Converter, Acute Radiation SyndromeDeath. Conversion Chart / Radiation Converter, Acute Radiation Syndrome

Acute Radiation Syndrome / Death Online converter page for a specific unit. Here you can make instant conversion from this unit ... Instant Conversion for Units of Radiation. Radiation Converter. Acute radiation syndrome.. Copyright © 1996-2019 by Sergey ... This is a conversion chart for death (Acute radiation syndrome). To switch the unit simply find the one you want on the page ... Absorbed and equivalent radiation doses can not be directly converted as the conversion depends on the type of radiation. On ...
more infohttps://www.convert-me.com/en/convert/radiation/rrdeath.html

Purpoura, Hemorrhage, Infections. Conversion Chart /
Radiation Converter, Acute Radiation SyndromePurpoura, Hemorrhage, Infections. Conversion Chart / Radiation Converter, Acute Radiation Syndrome

Acute Radiation Syndrome / Purpoura, Hemorrhage, Infections Online converter page for a specific unit. Here you can make ... Instant Conversion for Units of Radiation. Radiation Converter. Acute radiation syndrome.. Copyright © 1996-2019 by Sergey ... This is a conversion chart for purpoura, hemorrhage, infections (Acute radiation syndrome). To switch the unit simply find the ... Absorbed and equivalent radiation doses can not be directly converted as the conversion depends on the type of radiation. On ...
more infohttps://www.convert-me.com/en/convert/radiation/rrhemorrhage.html

Acute radiation syndrome - Radiation Effects Research FoundationAcute radiation syndrome - Radiation Effects Research Foundation

Acute radiation syndrome. Illnesses collectively called acute radiation syndrome occur within a few hours to months after ... Stram DO, Mizuno S: Analysis of the DS86 atomic-bomb radiation dosimetry using data on severe epilation. Radiation Research ... If the radiation dose is low, the syndrome will seldom if ever occur. Conversely, if the dose is high, death can occur within ... The Figure shows the relation of severe epilation (loss of more than 2/3 of scalp hair) to radiation dose. Although there is ...
more infohttp://rerf.jp/radefx/early_e/acute.html

Acute radiation syndrome - Stock Image M108/0775 - Science Photo LibraryAcute radiation syndrome - Stock Image M108/0775 - Science Photo Library

ARS occurs when the body is exposed to radiation in excess of four sieverts (the biological dose equivalent of radiation). The ... Affects of acute radiation syndrome (ARS), computer artwork. ... Acute radiation syndrome. M108/0775 Rights Managed. Request low ... Caption: Affects of acute radiation syndrome (ARS), computer artwork. ARS occurs when the body is exposed to radiation in ... Keywords: acute radiation syndrome, adult, artwork, bone, bone marrow, bones, brain, cerebral, concept, concepts, conceptual, ...
more infohttp://www.sciencephoto.com/media/250436/view

Global Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) Market Size, StatusGlobal Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) Market Size, Status

Radiation Sickness, Acute Radiation Syndrome) Market Size, Status and Forecast 2025 to its huge collection of research reports ... Radiation Sickness, Acute Radiation Syndrome). 1.1 Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) Market ... Acute Radiation Syndrome) Competition Analysis by Players. 2.1 Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome ... Acute Radiation Syndrome) market, analyzes and researches the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome ...
more infohttp://www.sbwire.com/press-releases/global-radiation-toxicity-radiation-sickness-acute-radiation-syndrome-market-research-applications-challenges-2025-943152.htm

Pluristem Concludes Positive Meeting with FDA on Development Plan for Acute Radiation SyndromePluristem Concludes Positive Meeting with FDA on Development Plan for Acute Radiation Syndrome

... regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). The FDA provided Pluristem ... Pluristem Concludes Positive Meeting with FDA on Development Plan for Acute Radiation Syndrome. ... regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). The FDA provided Pluristem ... These studies demonstrated PLX-R18 potential to increase survival rates after radiation exposure, as well as protect and ...
more infohttps://www.apnews.com/e25ac539b552ac78c413e5956528c0cc

Molecules  | Free Full-Text | Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise...Molecules | Free Full-Text | Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise...

... in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or ... this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. ... G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be ... anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with ...
more infohttp://www.mdpi.com/1420-3049/19/4/4770/htm

Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group...Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group...

During such an attack, people could suffer from the acute radiation syndrome. This syndrome is the collection of bodily effects ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ...
more infohttps://annals.org/aim/fullarticle/717560/medical-management-acute-radiation-syndrome-recommendations-strategic-national-stockpile-radiation

Orphan Drug Designation Granted to Potential Acute Radiation Syndrome TreatmentOrphan Drug Designation Granted to Potential Acute Radiation Syndrome Treatment

... a potential therapy for Acute Radiation Syndrome, has been granted Orphan Drug Designation by the U.S. Food and Drug ... Enzychem Lifesciences has announced that EC-18, a potential therapy for Acute Radiation Syndrome (ARS), has been granted Orphan ... Orphan Drug Designation Granted to Potential Acute Radiation Syndrome Treatment. JANUARY 22, 2018 ... ARS is developed after a patient is exposed to high amounts of radiation in a short period of time, breaking down immature ...
more infohttps://www.raredr.com/news/ec-18-orphan-drug-designation

Acute radiation syndrome - WikEMAcute radiation syndrome - WikEM

Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group ... Also called radiation poisoning, radiation toxicity, or radiation sickness.. *Acute illness caused by exposure to high doses ( ... Acute radiation syndrome. Revision as of 05:54, 22 June 2018 by Rossdonaldson1. (talk , contribs) (→‎External Links) ... Acute radiation syndrome: assessment and management. South Med J. 2010 Jun;103(6):541-6. ...
more infohttps://www.wikem.org/w/index.php?title=Acute_radiation_syndrome&oldid=182490

Chronic Myelogenic Leukemia, Developed at the Survivor of Acute Radiation Syndrome Severe Degree | RadioprotectionChronic Myelogenic Leukemia, Developed at the Survivor of Acute Radiation Syndrome Severe Degree | Radioprotection

... biological effects of ionising radiation or radiobiology - experimental studies (dosimetry, reactor physics, radiochemistry), ... Chronic Myelogenic Leukemia, Developed at the Survivor of Acute Radiation Syndrome Severe Degree. N. Nadezhina1, I. Galstyan1, ... sufficient for leading of the first results of supervision of the acute radiation syndrome (ARS) survivors. Among 10 patients ... The most typical is development of acute leukemia and chronic myelogenic leukemia 5-10 years later radiation exposure.. At the ...
more infohttps://www.radioprotection.org/articles/radiopro/abs/2008/05/000062/000062.html

Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome -...Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome -...

Filed Under: New Publications Tagged With: ER beta, ERb, ERβ, estrogen receptor, H-ARS, hematopoietic-acute radiation syndrome ... Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome. ... drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic-acute radiation syndrome (H-ARS). ... Date of publication: 30 April 2019; Journal of Radiation Research. Author information: Michael R. Landauer (1); Adam J. Harvey ...
more infohttps://indigobiosciences.com/mechanism-and-therapeutic-window-of-a-genistein-nanosuspension-to-protect-against-hematopoietic-acute-radiation-syndrome/

Acute radiation syndrome (Radiation sickness) - Diseases & ConditionsAcute radiation syndrome (Radiation sickness) - Diseases & Conditions

... acute). The amount of radiation absorbed by the body - the absorbed dose - determines how sick youll be. ... Radiation sickness is damage to your body caused by a large dose of radiation often received over a short period of time ( ... Radiation sickness is also called acute radiation sickness, acute radiation syndrome or radiation poisoning. Common exposures ... Complications of Acute radiation syndrome (Radiation sickness). Radiation exposure that causes immediate radiation sickness ...
more infohttps://pharmacypedia.org/diseases-and-conditions/acute-radiation-syndrome-radiation-sickness/

Acute radiation syndrome. Causes, symptoms, treatment Acute radiation syndromeAcute radiation syndrome. Causes, symptoms, treatment Acute radiation syndrome

Treatment Acute radiation syndrome. Symptoms and causes Acute radiation syndrome Prophylaxis Acute radiation syndrome ... Acute radiation syndrome: An acute illness caused by a dose greater than 50 rads of penetrating radiation to most or all of the ... There are three ARS syndromes: the bone marrow syndrome (or hematologic syndrome), the gastrointestinal (GI) syndrome, and the ... Examples of persons who suffered from acute radiation syndrome (ARS) are the survivors of the Hiroshima and Nagasaki atomic ...
more infohttp://dxline.info/dictionary/acute-radiation-syndrome

Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome)-Pipeline Insights, 2016 | Global Market Research ReportsRadiation Toxicity (Radiation Sickness, Acute Radiation Syndrome)-Pipeline Insights, 2016 | Global Market Research Reports

Radiation Sickness, Acute Radiation Syndrome) Overview. • Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) ... Radiation Sickness, Acute Radiation Syndrome) - Discontinued Products • Radiation Toxicity (Radiation Sickness, Acute Radiation ... Acute Radiation Syndrome) Phase II Products. • Comparative Analysis • Radiation Toxicity (Radiation Sickness, Acute Radiation ... Acute Radiation Syndrome) Therapeutics under Development by Companies • Radiation Toxicity (Radiation Sickness, Acute Radiation ...
more infohttp://www.gosreports.com/radiation-toxicity-radiation-sickness-acute-radiation-syndrome-pipeline-insights-2016/

PSRC - Donor-Recipient Chimeric Cell Transplantation as a Novel Rescue Therapy for Acute Radiation Syndrome: A Preliminary...PSRC - Donor-Recipient Chimeric Cell Transplantation as a Novel Rescue Therapy for Acute Radiation Syndrome: A Preliminary...

Victims of nuclear disasters present with acute radiation syndrome as a result of exposure to ionizing radiation. Impairment of ... Donor-Recipient Chimeric Cell Transplantation as a Novel Rescue Therapy for Acute Radiation Syndrome: A Preliminary Report. ... Therefore there is an urgent need to develop new effective therapies of acute radiation syndrome. The aim of this study was to ... of DRCC after ionizing radiation exposure proved to be the most effective rescue therapy against acute radiation syndrome, as ...
more infohttp://www.ps-rc.org/meeting/abstracts/2014/90.cgi

Pluristem to Present Data on PLX-R18 in Treatment of Acute Radiation Syndrome at American Society of Hematologys Annual...Pluristem to Present Data on PLX-R18 in Treatment of Acute Radiation Syndrome at American Society of Hematology's Annual...

Pluristem to Present Data on PLX-R18 in Treatment of Acute Radiation Syndrome at American Society of Hematologys Annual ... the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome ... The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. This study ... exposed to high levels of radiationPLX-R18 cells are in late-stage development as a treatment for ARS, supported by the U.S. ...
more infohttp://dailytelescope.com/pr/pluristem-to-present-data-on-plx-r18-in-treatment-of-acute-radiation-syndrome-at-american-society-of-hematologys-annual-meeting/26797

Pluristem to Present Data on PLX-R18 in Treatment of Acute Radiation Syndrome at American Society of Hematologys Annual...Pluristem to Present Data on PLX-R18 in Treatment of Acute Radiation Syndrome at American Society of Hematology's Annual...

Pluristem to Present Data on PLX-R18 in Treatment of Acute Radiation Syndrome at American Society of Hematologys Annual ... the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome ... The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. This study ... and radiation damage. The cells are grown using the Companys proprietary three-dimensional expansion technology and can be ...
more infohttp://globenewswire.ca/news-release/2017/12/07/1247283/0/en/Pluristem-to-Present-Data-on-PLX-R18-in-Treatment-of-Acute-Radiation-Syndrome-at-American-Society-of-Hematology-s-Annual-Meeting.html?culture=fr-ca

Radiation Health Effects | Radiation Protection | US EPARadiation Health Effects | Radiation Protection | US EPA

Acute radiation syndrome from large exposures. *Radiation exposure and cancer risk *Limiting cancer risk from radiation in the ... can cause acute health effects such as skin burns and acute radiation syndrome ("radiation sickness"). It can also result in ... Acute Radiation Syndrome from Large Exposures. A very high level of radiation exposure delivered over a short period of time ... It takes a very high radiation exposure to cause acute radiation syndrome-more than 75 rad. radThe U.S. unit used to measure ...
more infohttps://www.epa.gov/radiation/radiation-health-effects

Cardiovascular SyndromeCardiovascular Syndrome

... on WN Network delivers the latest Videos and Editable pages for News & Events, including Entertainment ... Acute radiation syndrome. Acute radiation syndrome (ARS), also known as radiation poisoning, radiation sickness or radiation ... Treatment of acute radiation syndrome is generally supportive with blood transfusions and antibiotics, with some more ... This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Acute_radiation_syndrome ...
more infohttps://wn.com/Cardiovascular_syndrome?from=cardiovascularsyndrome.com

Neulasta Dosage Guide - Drugs.comNeulasta Dosage Guide - Drugs.com

Use of the OBI for Neulasta is not recommended for patients with Hematopoietic Subsyndrome of Acute Radiation Syndrome. Use of ... Patients with Hematopoietic Subsyndrome of Acute Radiation Syndrome. The recommended dose of Neulasta is two doses, 6 mg each, ... Estimate a patients absorbed radiation dose (i.e., level of radiation exposure) based on information from public health ... Administer the first dose as soon as possible after suspected or confirmed exposure to radiation levels greater than 2 gray (Gy ...
more infohttps://www.drugs.com/dosage/neulasta.html

Smartcard To Convey Radiation Risks Of Adult Radiologic Exams: Radiology DepartmentSmartcard To Convey Radiation Risks Of Adult Radiologic Exams: Radiology Department

... pocket-sized reference card to communicate the effective doses and radiation risks of common adult radiologic exams to ... Acute Radiation Syndrome. Acute radiation syndrome occurs when a person is exposed to a high dose of external penetrating ... Radiotherapy X-Ray Radiation Hazards Acute Radiation Syndrome Gamma Camera / Scintillation Camera ... Radiation Hazards. Ionizing radiation can damage living tissue in the human body. It strips away electrons from atoms breaks ...
more infohttp://www.medindia.net/news/smartcard-to-convey-radiation-risks-of-adult-radiologic-exams-radiology-department-99932-1.htm
  • WASHINGTON -- Two contracts for advanced development of drugs to treat skin and lung injuries associated with acute radiation syndrome (ARS) were awarded this week by the U. (freethesaurus.com)
  • Her research has spanned drug discovery, preclinical development, manufacturing and clinical development in indications such as acute radiation syndrome , inflammation, infectious disease, cancer and cancer supportive care. (freethesaurus.com)
  • Presenting the research to the 2nd Forum of the European Society for Radiotherapy and Oncology (ESTRO) today (Sunday), Dr Sonja Van der Veen, MSc, from the University Medical Centre, Groningen, The Netherlands, said that she had set out with colleagues to see whether the use of an ACE inhibitor could protect against early radiation-induced lung toxicity (RILT). (medindia.net)
  • We are pleased to see interest from key governmental agencies such as NIAID, the U.S Department of Defense and BARDA in our novel regenerative medical countermeasure for radiation injuries and look forward to potentially supporting such medical needs of the U.S. government. (apnews.com)
  • For example, Pluristem is using forward-looking statements when it states its belief that, as a result of its meeting with the FDA, it has a clear and efficient path towards advancing the development of PLX-R18 in the treatment of ARS and its potential support of the U.S. government with respect to its medical needs relating to radiation injuries. (apnews.com)
  • Colwell CB: Radiation injuries, in Marx JA, Hockberger RS, Walls RM, et al (eds): Rosen's Emergency Medicine: Concepts and Clinical Practice, ed 8. (wikem.org)
  • At development leukemia at ARS survivors, "hyperregeneration" - hemopoesis with increasing of neutrophils amount (in the absence of consequences of local radiation injuries) within the first years after an irradiation can form a basis for leukogenic transformation. (radioprotection.org)
  • Cell technologies for replacement of skin defects at the patient with local radiation injuries. (radioprotection.org)
  • WASHINGTON -- Two contracts for advanced development of drugs to treat skin and lung injuries associated with acute radiation syndrome (ARS) were awarded this week by the U. (freethesaurus.com)
  • Twenty one year which has passed after Chernobyl NPP accident, is term, sufficient for leading of the first results of supervision of the acute radiation syndrome (ARS) survivors. (radioprotection.org)
  • Examples of persons who suffered from acute radiation syndrome (ARS) are the survivors of the Hiroshima and Nagasaki atomic bombs and the firefighters that first responded after the Chernobyl Nuclear Power Plant event in 1986. (dxline.info)
  • There have been studies that kept track of large numbers of people who were exposed to radiation, including atomic bomb survivors and radiation industry workers. (epa.gov)
  • HAIFA, Israel, Jan. 03, 2019 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (Nasdaq:PSTI) (TASE:PSTI), a leading regenerative medicine company developing novel placenta-based cell therapy products, today announced it has concluded a positive meeting with the U.S. Food and Drug Administration (FDA) regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). (apnews.com)
  • G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future. (mdpi.com)
  • The treatment of radiation accident victims has been in the focus of attention of investigators in many laboratories. (mdpi.com)
  • PSTI ), a leading developer of placenta-based cell therapy products, announced today the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome (ARS) at the American Society of Hematology's (ASH) 59th Annual Meeting to be held in Atlanta, Georgia, on December 9-12, 2017. (dailytelescope.com)
  • A detailed account of radiation, its mode of action, side effects and dosage in the treatment of cancer. (medindia.net)
  • We believe that our results suggest a promising strategy for shielding patients from radiation damage and improving their quality of life, while at the same time allowing them to receive a high enough dose to ensure the effective treatment of their cancer. (medindia.net)
  • ARS is developed after a patient is exposed to high amounts of radiation in a short period of time, breaking down immature parenchymal stem cells in tissues due to the irradiation of the entire body. (raredr.com)
  • Dr Van der Veen and her colleagues are now collaborating with a research group from the Mayo Clinic, Rochester, Minnesota (USA), in order to design a randomised clinical trial where patients who are treated with radiation to the thoracic area including the heart will be treated with either an ACE inhibitor or a placebo after irradiation. (medindia.net)
  • PLX cell products release a range of therapeutic proteins in response to inflammation, ischemia, muscle trauma, hematological disorders, and radiation damage. (apnews.com)
  • Her research has spanned drug discovery, preclinical development, manufacturing and clinical development in indications such as acute radiation syndrome , inflammation, infectious disease, cancer and cancer supportive care. (freethesaurus.com)
  • These findings, which show recovery of the hematologic system, suggest that PLX-R18 has the potential to treat a large population exposed to different levels of radiation and might also be used for additional hematologic indications. (dailytelescope.com)
  • For example, Pluristem is using forward-looking statements when its discusses that PLX-R18 has the potential to treat a large population exposed to different levels of radiation and might also be used for additional hematologic indications, and the potential market for such indications. (dailytelescope.com)
  • Radiation accidents are fortunately infrequent but their health consequences are serious and they have the potential of resulting in large-scale events [ 1 ]. (mdpi.com)
  • Illnesses collectively called 'acute radiation syndrome' occur within a few hours to months after exposure to high-dose radiation (from approximately 1-2 Gy to 10 Gy). (rerf.jp)
  • Understanding the type of radiation received, the way a person is exposed (external vs. internal), and for how long a person is exposed are all important in estimating health effects. (epa.gov)
  • High energy X-rays , gamma rays , and neutrons are penetrating radiations. (citizendium.org)
  • It is the world's only company producing PPE intended to protect users from high energy gamma radiation and the first to employ partial shielding in its products. (wikipedia.org)
  • How much you absorb depends on the strength of the radiated energy and the distance between you and the source of radiation. (pharmacypedia.org)
  • Depending on the mechanism of radiation, burns that appear immediately may be thermal rather than radiation injury, although complex mechanisms, not fully understood, are involved in radiation effects on the skin. (citizendium.org)
  • It was the largest nuclear disaster since the Chernobyl disaster of 1986, and the radiation released exceeded official safety guidelines. (wikipedia.org)
  • The radiation must be penetrating [i.e., ionizing]. (citizendium.org)
  • Victims of nuclear disasters present with acute radiation syndrome as a result of exposure to ionizing radiation. (ps-rc.org)
  • Ionizing radiation Radiation with so much energy it can knock electrons out of atoms. (epa.gov)
  • Ionizing radiation can affect the atoms in living things, so it poses a health risk by damaging tissue and DNA in genes. (epa.gov)
  • EPA bases its regulatory limits and nonregulatory guidelines for public exposure to low level ionizing radiation on the linear no-threshold (LNT) model. (epa.gov)
  • StemRad is an Israeli-American company headquartered in Tel Aviv, Israel, that develops, manufactures and sells personal protective equipment (PPE) for ionizing radiation. (wikipedia.org)
  • According to co-founder Dr. Oren Milstein, "This is the first product of its kind that protects against gamma radiation, which has until now killed people who have been exposed to it. (wikipedia.org)
  • This type of shielding is effective only for blocking of alpha and beta radiation, yet is ineffective in blocking highly penetrating gamma radiation. (wikipedia.org)
  • Existing shielding is therefore incapable of preventing the acute health effects of exposure to gamma radiation (i.e. (wikipedia.org)
  • The Figure shows the relation of severe epilation (loss of more than 2/3 of scalp hair) to radiation dose. (rerf.jp)
  • Stram DO, Mizuno S: Analysis of the DS86 atomic-bomb radiation dosimetry using data on severe epilation. (rerf.jp)
  • Information about the acute radiation syndrome comes from studies of animals, studies of accidents at nuclear power plants, or studies of the effects of the atomic bomb detonated over Hiroshima, Japan. (annals.org)
  • The radiation exposure levels in a nuclear catastrophe, such as in an atomic bomb detonation or following a nuclear power plant reactor meltdown, are largely within this range. (wikipedia.org)
  • 5,000-10,000 millirem or 50-100 millisieverts) usually result in no harmful health effects, because radiation below these levels is a minor contributor to our overall cancer risk. (epa.gov)
  • Given the uncertain health effects of low-dose radiation, cancer deaths cannot be ruled out. (wikipedia.org)
  • Acute radiation syndrome is rare, and comes from extreme events like a nuclear explosion or accidental handling or rupture of a highly radioactive source. (epa.gov)