Acute Radiation Syndrome: A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.Radioactive Hazard Release: Uncontrolled release of radioactive material from its containment. This either threatens to, or does, cause exposure to a radioactive hazard. Such an incident may occur accidentally or deliberately.Radiation Injuries, Experimental: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.Radiation Injuries: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.Radiation-Protective Agents: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Lethal Dose 50: The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Radiodermatitis: A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.Syndrome: A characteristic symptom complex.Radiation Pneumonitis: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Nuclear Warfare: Warfare involving the use of NUCLEAR WEAPONS.JapanFoundations: Organizations established by endowments with provision for future maintenance.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Radium: Radium. A radioactive element of the alkaline earth series of metals. It has the atomic symbol Ra, atomic number 88, and atomic weight 226. Radium is the product of the disintegration of uranium and is present in pitchblende and all ores containing uranium. It is used clinically as a source of beta and gamma-rays in radiotherapy, particularly BRACHYTHERAPY.Radiation ProtectionFlax: A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.Radiation Monitoring: The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.PaintCosmic Radiation: High-energy radiation or particles from extraterrestrial space that strike the earth, its atmosphere, or spacecraft and may create secondary radiation as a result of collisions with the atmosphere or spacecraft.Bombs: A weapon designed to explode when deployed. It frequently refers to a hollow case filled with EXPLOSIVE AGENTS.Nuclear Weapons: A weapon that derives its destructive force from nuclear fission and/or fusion.Asia, Southeastern: The geographical area of Asia comprising BORNEO; BRUNEI; CAMBODIA; INDONESIA; LAOS; MALAYSIA; the MEKONG VALLEY; MYANMAR (formerly Burma), the PHILIPPINES; SINGAPORE; THAILAND; and VIETNAM.SculptureBone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.CitratesCatheters, Indwelling: Catheters designed to be left within an organ or passage for an extended period of time.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.Radiobiology: Study of the scientific principles, mechanisms, and effects of the interaction of ionizing radiation with living matter. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Granulocyte-Macrophage Progenitor Cells: The parent cells that give rise to both cells of the GRANULOCYTE lineage and cells of the monocyte/macrophage lineage.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)District of Columbia: A federal area located between Maryland and Virginia on the Potomac river; it is coextensive with Washington, D.C., which is the capital of the United States.Hematopoietic System: The blood-making organs and tissues, principally the bone marrow and lymph nodes.Minicomputers: Small computers that lack the speed, memory capacity, and instructional capability of the full-size computer but usually retain its programmable flexibility. They are larger, faster, and more flexible, powerful, and expensive than microcomputers.Cesium Radioisotopes: Unstable isotopes of cesium that decay or disintegrate emitting radiation. Cs atoms with atomic weights of 123, 125-132, and 134-145 are radioactive cesium isotopes.Film Dosimetry: Use of a device (film badge) for measuring exposure of individuals to radiation. It is usually made of metal, plastic, or paper and loaded with one or more pieces of x-ray film.Health Physics: The science concerned with problems of radiation protection relevant to reducing or preventing radiation exposure, and the effects of ionizing radiation on humans and their environment.Radiation Equipment and Supplies: Instruments and apparatus for radiation applications and their components and associated expendables.

Expression of phospho-Elk-1 in rat gut after the whole body gamma irradiation. (1/35)

Gastrointestinal form is the second stage of acute radiation syndrome (ARS) with a threshold dose of 8 Gy in man. It represents an absolutely lethal clinical-pathological unit, necro-hemorrhagic enteritis and proctocolitis, with unknown causal therapy. Elk-1 is a protein acting as a transcription factor activating specified genes. The purpose of our study was to examine the expression of phospho-Elk-1 in irradiated jejunum and transversal colon of rats with radiation-induced enterocolitis and to assess the importance of this transcriptional factor as a biodosimetric marker of radiation-induced enteropathy. The laboratory rats were randomly divided into 21 groups, 10 animals per group, and irradiated with whole body gamma-irradiation of 1, 5, 10, 15, and 20 Gy. Samples of jejunum and transversal colon were taken 24, 48, 72, and 96 hours later, immunohisto-chemically stained, and the phospho-Elk-1 expression was examined using computer image analysis. A group of 10 sham-irradiated animals was used as control. Significantly increased expression of phospho-Elk-1 in rat jejunum has been found in all time intervals after irradiation by sublethal doses of 1 and 5 Gy, whereas after the irradiation by lethal doses, the expression of phospho-Elk-1 in rat jejunum varied considerably. Significantly increased expression of phospho-Elk-1 in transversal colon has also been found in the first days after irradiation by sublethal doses of 1 and 5 Gy. After irradiation by lethal doses, there was no uniform pattern of the changes in the expression of phospho-Elk-1 in rat transversal colon. The detection of phospho-Elk-1 might be considered as a suitable and very sensitive biodosimetric marker of radiation-induced injury of small and large intestine. According to our knowledge, this is the first study on the phospho-Elk-1 expression in irradiated jejunum and transversal colon in the rat.  (+info)

Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. (2/35)

Neurogenesis in the adult hippocampus, which occurs constitutively, is vulnerable to ionizing radiation. In the relatively low-dose exposure of acute radiation syndrome (ARS), the change in the adult hippocampal function is poorly understood. This study analyzed the changes in apoptotic cell death and neurogenesis in the DGs of hippocampi from adult ICR mice with single whole-body gamma-irradiation using the TUNEL method and immunohistochemical markers of neurogenesis, Ki-67 and doublecortin (DCX). In addition, the hippocampus-dependent learning and memory tasks after single whole-body gamma-irradiation were examined in order to evaluate the hippocampus-related behavioral dysfunction in the relatively low-dose exposure of ARS. The number of TUNEL-positive apoptotic nuclei in the dentate gyrus (DG) was increased 6-12 h after acute gamma-irradiation (a single dose of 0.5 to 4 Gy). In contrast, the number of Ki-67- and DCX-positive cells began to decrease significantly 6 h postirradiation, reaching its lowest level 24 h after irradiation. The level of Ki-67 and DCX immunoreactivity decreased in a dose-dependent manner within the range of irradiation applied (0-4 Gy). In passive avoidance and object recognition memory test, the mice trained 1 day after acute irradiation (2 Gy) showed significant memory deficits, compared with the sham controls. In conclusion, the pattern of the hippocampus-dependent memory dysfunction is consistent with the change in neurogenesis after acute irradiation. It is suggested that a relatively low dose of ARS in adult ICR mice is sufficiently detrimental to interrupt the functioning of the hippocampus, including learning and memory, possibly through the inhibition of neurogenesis.  (+info)

Dose estimation by chromosome aberration analysis and micronucleus assays in victims accidentally exposed to (60)Co radiation. (3/35)

 (+info)

The radiation protection and therapy effects of mesenchymal stem cells in mice with acute radiation injury. (4/35)

 (+info)

Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation. (5/35)

This study examined whether amifostine (WR-2721) could attenuate memory impairment and suppress hippocampal neurogenesis in adult mice with the relatively low-dose exposure of acute radiation syndrome (ARS). These were assessed using object recognition memory test, the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunohistochemical markers of neurogenesis [Ki-67 and doublecortin (DCX)]. Amifostine treatment (214 mg/kg, i.p.) prior to irradiation significantly attenuated the recognition memory defect in ARS, and markedly blocked the apoptotic death and decrease of Ki-67- and DCX-positive cells in ARS. Therefore, amifostine may attenuate recognition memory defect in a relatively low-dose exposure of ARS in adult mice, possibly by inhibiting a detrimental effect of irradiation on hippocampal neurogenesis.  (+info)

Radiation rescue: mesenchymal stromal cells protect from lethal irradiation. (6/35)

 (+info)

Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation. (7/35)

 (+info)

Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident. (8/35)

 (+info)

Looking for online definition of acute radiation syndrome in the Medical Dictionary? acute radiation syndrome explanation free. What is acute radiation syndrome? Meaning of acute radiation syndrome medical term. What does acute radiation syndrome mean?
Synonyms for Acute radiation syndrome in Free Thesaurus. Antonyms for Acute radiation syndrome. 7 synonyms for syndrome: condition, complaint, illness, symptoms, disorder, ailment, affliction. What are synonyms for Acute radiation syndrome?
This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.
HAIFA, Israel, Dec. 07, 2017 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (NASDAQ:PSTI) (TASE:PSTI), a leading developer of placenta-based cell therapy products, announced today the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome (ARS) at the American Society of Hematologys (ASH) 59th Annual Meeting to be held in Atlanta, Georgia, on December 9-12, 2017.. The results of the study will be presented during Program Session 506: Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion, and Stromal Stem Cells. The poster, "Intramuscular Administration of Placenta-Derived Stromal Cells Enhances Survival of Rhesus Macaque Monkeys Exposed to Total Body Irradiation," will describe data from a recently announced Phase II-equivalent study under the U.S. Food and Drug Administration (FDA) Animal Rule. The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. This ...
Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) - Pipeline Review, H1 2017, provides an overview of the Radiation Toxicity (Radiation Sic
Acute effects of ionizing radiation were first observed when Wilhelm Röntgen intentionally subjected his fingers to X-rays in 1895. He published his observations concerning the burns that developed that eventually healed, and misattributed them to ozone. Röntgen believed the free radical produced in air by X-rays from the ozone was the cause, but other free radicals produced within the body are now understood to be more important. D. Walsh first established the symptoms of radiation sickness in 1897. Ingestion of radioactive materials caused many radiation-induced cancers in the 1930s, but no one was exposed to high enough doses at high enough rates to bring on acute radiation syndrome. The Radium Girls were female factory workers who contracted radiation poisoning from painting watch dials with self-luminous paint at the United States Radium factory in Orange, New Jersey, around 1917. The atomic bombings of Hiroshima and Nagasaki resulted in high acute doses of radiation to a large number of ...
After irradiation with 2, 4, 7, or 12 Gy, changes in the bone marrow cells over time were examined through H&E staining and Ki-67 staining, a proliferation marker. In minipigs irradiated with 2 or 4 Gy, the myeloid hematopoietic cells disappeared drastically, starting at 30 minutes after irradiation; at the 17-hour point, only a minimal number of myeloid cells remained. On day 3 after irradiation, only some plasmacytoid cells and erythroblasts were observed; Ki-67 positive cells were hardly found (Figure 4A and B). For minipigs irradiated with 7 or 12 Gy, bone marrow tissues were obtained when they succumbed. In the histological analysis, we found that the bone marrow of these 2 minipigs was replaced with adipose cells, with a very small number of plasmacytoid myeloid cells. Moreover, few Ki-67 positive cells were found in the bone marrow (Figure 4C ...
Some may think that certain data are emphasized in this and other chapters in an attempt to minimize the dangers of exposure to radiation. This is not at all true. I am trying to put the dangers in perspective and eliminate the Pavlovian negative response to even the very mention of the subject. Table 8 shows the accepted syndrome from short-term exposures. Please note that this table is in rems (not millirems) and can be mentally converted to centisieverts (cSvs) of the same numerical value. Radiation can obviously be very dangerous. But so can an unreasonable fear of radiation ...
Sixteen Lewis (RT1l) rats were exposed to sublethal dose (7Gy) of Cs-137 TBI. Irradiated rats were divided into 4 experimental groups (n=4 each) based on therapeutic approach: Group 1 - no intervention; Group 2 - normal saline injection; Group 3 - allogeneic bone marrow transplantation (BMT) [ACI (RT1a)]; and Group 4 - DRCC transplantation [ACI/LEW (RT1a/RT1l]. Saline as well as cellular therapeutics were delivered into the femoral bone at 6 hours following TBI. DRCC were created by ex-vivo fusion of bone marrow cells derived from fully MHC mismatched LEW (RT1l) and ACI (RT1a) donors. Briefly, donor and recipient cells were isolated, separately stained with the PKH26 and PKH67 fluorescent dyes, fused with polyethylene glycol (PEG) and sorted by flow cytometry. Cells presenting double staining were transplanted in a dose 10-12 x 106. All animals received supportive treatment with prophylactic antibiotics, fluids, and softened food during 90-days follow-up. Blood samples were evaluated using ...
Disaster Med Public Health Prep. 2011 Oct;5(3):202-12. doi: 10.1001/dmp.2011.68. Epub 2011 Oct 10. Research Support, Non-U.S. Govt; Review
Exposure to high doses of ionizing radiation in the event of therapeutic, accidental or intentional incident such as nuclear/radiological warfare can lead to debilitating injuries to multiple organs resulting in death within days depending on the amount of radiation dose and the quality of radiation. Unfortunately, there is not a single FDA-licensed drug approved against acute radiation injury.. Radiation damage to multiple organs often described as multiple organ dysfunction syndrome (MODS) or acute radiation syndrome (ARS) results from rapid depletion of radiosensitive cells, these cells are usually the stem or progenitor cells with high proliferative capacity; naturally, bone marrow stem cells (BMSC), and intestinal stem cells (ISC), which are extremely critical in maintaining a pool of peripheral blood cells and in maintaining villi for the absorption of nutrients are highly sensitive to radiation. One of the most efficient ways of rescuing MODS is to administer fresh cells that can repair, ...
Date: August 22, 2013. Company: BCN Biosciences, headquartered in Pasadena, Calif.. Cooperative agreement amount: BARDA will contribute $4 million over two years About the cooperative agreement: Through this cooperative agreement, BARDA will fund and collaborate on proof-of-concept studies by BCN Biosciences to determine how well a novel small molecule called Yel002, created by the company, protects DNA from damage after the bodys cells are exposed to damaging levels of radiation. This approach may increase the likelihood that cells in the gastrointestinal injury will survive exposure to acute radiation.. The GI tract is particularly sensitive to radiation but currently there is no treatment or preventive measure for this type of ionizing (damaging) radiation injury.. Acute Radiation Syndrome, also known as ARS, is a serious illness that occurs when all or most of the body receives a high dose of radiation, such as after the detonation of a nuclear device. ARS involves injuries to the bodys ...
Purpose: Discovery of agents that protect or mitigate normal tissue from radiation injury during radiotherapy, accidents, or terrorist attacks is of importance. Specifically, bone marrow insufficiency, with possible infection due to immunosuppression, can occur after total body irradiation (TBI) or regional irradiation and is a major component of the acute radiation syndrome. The purpose of this study was to identify novel radioprotectors and mitigators of the hematopoietic system.. Experimental Design: High-throughput screening of small-molecule libraries was done using viability of a murine lymphocyte line as a readout with further validation in human lymphoblastoid cells. The selected compounds were then tested for their ability to counter TBI lethality in mice.. Results: All of two major classes of antibiotics, tetracyclines and fluoroquinolones, which share a common planar ring moiety, were radioprotective. Furthermore, tetracycline protected murine hematopoietic stem/progenitor cell ...
Exposure to a moderate to high dose of ionizing radiation (IR) not only causes acute radiation syndrome but also induces long-term (LT) bone marrow (BM) injury. The latter effect of IR is primarily attributed to the induction of hematopoietic stem cell (HSC) senescence. Granulocyte colony-stimulating factor (G-CSF) is the only treatment recommended to be given to radiation victims soon after IR. However, clinical studies have shown that G-CSF used to treat the leukopenia induced by radiotherapy or chemotherapy in patients can cause sustained low white blood cell counts in peripheral blood. It has been suggested that this adverse effect is caused by HSC and hematopoietic progenitor cell (HPC) proliferation and differentiation stimulated by G-CSF, which impairs HSC self-renewal and may exhaust the BM capacity to exacerbate IR-induced LT-BM injury. C57BL/6 mice were exposed to 4 Gy γ-rays of total body irradiation (TBI) at a dose-rate of 1.08 Gy per minute, and the mice were treated with G-CSF (1 μg/each
Mass casualty scenarios of radiation exposure require high throughput biological dosimetry techniques for population triage, in order to rapidly identify individuals, who require clinical treatment. Accurate dose estimates can be made by biological dosimetry, to predict the acute radiation syndrome (ARS) within days after a radiation accident or a malicious act involving radiation. Timely information on dose is important for the medical management of acutely irradiated persons [1]. The aim of the study was to evaluate the usefulness of the micronuclei (MNi) scoring procedure in an experimental mode, where 500 binucleated cells were analyzed in different exposure dose ranges. Whole-body exposure was simulated in an in vitro experiment by irradiating whole blood collected from one healthy donor with 60 MeV protons and 250 keV X-rays, in the dose range of 0.3-4.0 Gy. For achieving meaningful results, sample scoring was performed by three independent persons, who followed guidelines described in ...
Cancer is a stochastic effect of radiation, meaning that the probability of occurrence increases with effective radiation dose, but the severity of the cancer is independent of dose. The speed at which cancer advances, the prognosis, the degree of pain, and every other feature of the disease are not functions of the radiation dose to which the person is exposed. This contrasts with the deterministic effects of acute radiation syndrome which increase in severity with dose above a threshold. Cancer starts with a single cell whose operation is disrupted. Normal cell operation is controlled by the chemical structure of DNA molecules, also called chromosomes. When radiation deposits enough energy in organic tissue to cause ionization, this tends to break molecular bonds, and thus alter the molecular structure of the irradiated molecules. Less energetic radiation, such as visible light, only causes excitation, not ionization, which is usually dissipated as heat with relatively little chemical damage. ...
SIGNS AND SYMPTOMS/ /ACUTE RADIATION SYNDROME/ Fifty persons involved in the cesium-137 accident in Goiania showed symptoms of whole-body and local acute irradiation and also external or internal contamination mainly due to ingestion or absorption of cesium-137. Fourteen of the 50 developed severe bone marrow depression characterized by neutropenia and thrombocytopenia. Eight of these 14 received GM-CSF intravenously. None were submitted to bone marrow transplantation. Four of the 14 died due to hemorrhage and infection. For those with significant internal contamination evaluated by in-vitro and in-vivo assays, Prussian Blue was administered with doses ranging from 1.5 to 10 g/day. Besides Prussian Blue, other measures were taken to increase decorporation of cesium-137, including administration of diuretics, water overload, and ergometric exercises. From 50 to 100 persons are being followed in a medical protocol ...
HAIFA, Israel, July 18, 2013-- Pluristem Therapeutics Inc., a leading developer of placenta-based cell therapies, announced today that the U.S. National Institute of Allergy and Infectious Diseases, part of the U.S. National Institutes of Health, has recommended to Pluristem that NIAID expand the scope of its ongoing animal research using PLX-RAD cells for the treatment of acute radiation syndrome.
Appropriate models are essential for making the transition from scientific discoveries to meaningful applications of the knowledge for human use. Acute as well as delayed effects of ionising radiation to the biological systems develop hierarchically starting from damage to the vital macromolecules up to the disturbances caused at the whole organism level. In vitro models like bacteria, yeast, various mammalian cells cultured as monolayers (2-D) and spheroids (3-D) as well as cells with specific genetic alterations have provided insight into the complex relationships between damage induction and various signal transduction pathways, allowing identification of molecular and sub-cellular targets vital to the fate of irradiated cells. On the other hand, in vivo models (multicellular whole organisms), ranging from simple worms to non-human primates, have been gainfully employed to evaluate efficacy as well as toxicity of potential countermeasure agents (molecules, combinations and formulated ...
The study assessed the safety and efficacy of Pluristem Therapeutics PLX-R18 following intramuscular injection into irradiated and non-irradiated NHPs.
Degenerative changes occur as soon as 30 minutes after exposure of 500-1000 rad. Initial effects are: impaired secretion of necessary fluids: cell breakdown results in failure of food and water absorption leading to infection and dehydration from diarrhea ...
Radiation doses exceeding a threshold of about 500 millisieverts (mSv) can cause tissue reactions in the human body, also called deterministic effects. They are the result of a massive cell killing and the subsequent loss of function of the affected organs or tissues. Particularly ...
Radiation doses exceeding a threshold of about 500 millisieverts (mSv) can cause tissue reactions in the human body, also called deterministic effects. They are the result of a massive cell killing and the subsequent loss of function of the affected organs or tissues.
NSWP is publishing the results of a global consultation exercise, carried out with our members in every region, and now written up into all the five languages of NSWP, for December 17th, International Day to End Violence Against Sex Workers.
The rationale for the use of the Animal Rule must be supported by proof-of-concept animal studies designed to ensure animal welfare, demonstrate relevance of the animal model (species susceptibility to the toxic agent and toxic response similar to humans), define the endpoint used to assess efficacy and predict human clinical benefit (eg, relief or prevention of adverse effects), ensure data quality and integrity in a contained environment, and be conducted under Good Laboratory Practice (GLP) guidelines. When efficacy is demonstrated in a single study, conducted in a sufficiently well‑characterized animal model, it may be necessary to repeat the study, preferably in another laboratory for confirmation. The investigational drug/biologic used in the adequate and well-controlled animal efficacy studies and in the animal pharmacokinetics and/or pharmacodynamics studies used to select a dose and dosing regimen in humans, ideally should be manufactured under current GMP regulations and be as close ...
Read Transcript, Download (.mov, 14MB). This final segment introduces the Clinical Decision Guide, a critical benchmark that can be used by clinicians in addition to other factors to help determine if medical countermeasures are indicated for a particular patient.. The Clinical Decision Guide (CDG) is an operational quantity that is specific to a type of radionuclide and a route of exposure (e.g. cesium-137 inhalational exposure). The CDG of children (0-18 yrs) and pregnant women is 20% that of adults.. For most radionuclides, the CDG is defined by the amount (activity) of radioactive material delivering an effective dose of 0.25 Sieverts (Sv) after incorporation into the body. This dose represents about a 1.3% lifetime risk of fatal cancer attributable to the exposure. Radiation measurements from a urine sample above a CDG value suggest the potential for a higher attributable lifetime fatal cancer risk and may help clinicians decide whether or not to start countermeasure treatment.. The CDG can ...
The National Institutes of Health recently posted a solicitation for the development of medical countermeasures to enhance platelet regeneration and survival following radiation exposure from a nuclear or radiological incident.
NAM and EATG, Europes community group for people with HIV, have launched a consensus statement, for endorsement by the HIV community, on using HIV treatment to prevent the transmission of HIV. ART drugs if taken as prescribed can effectively render people non-infectious. This treatment has not already ended the HIV epidemic for several reasons including lack of access to drugs, no global consensus on who should get them,.... ...
Aim 2: Perform preliminary countermeasure evaluation using radioprotective/chemopreventive agents that target common pathways of radiation induced injury (e.g. inflammation).. ...
The premier source of breaking business news for the government contracting industry, GovCon Wire provides informative, to-the-point stories of the most significant contract awards, top-level executive moves, M&A activities and financial results of the sectors most notable players.. GovCon Wire is always on top of the most recent contracting sector activity and is updated in real time as the news breaks. ...
Illnesses collectively called acute radiation syndrome occur within a few hours to months after exposure to high-dose radiation (from approximately 1-2 Gy to 10 Gy). The principal signs and symptoms include vomiting within a few hours, followed within days to weeks by diarrhea, reduced blood cell counts, bleeding, hair loss (epilation), and temporary male sterility. Diarrhea results from damage to cells lining the intestines, reduction in blood cells from death of hematopoietic stem cells in bone marrow, and bleeding from declining blood platelets generated from such stem cells. Hair is lost due to damage to hair-root cells. Hairs do not fall out but rather become thinner and eventually break off. Sterility occurs in men from damage to sperm-generating stem cells ...
HealthDay News) -- Once astronauts leave the Earths protective magnetic field, their cancer risk would soar while traveling to Mars, new research indicates.. Scientists said radiation exposure during a long-term deep-space mission would not only affect already damaged cells but also healthy ones nearby, doubling cancer risk.. Cosmic rays cause significant cell damage due from exposure to radiation, protons and heavy ions, the authors explained. Previous research has shown the health risks of deep space travel include cancer, cataracts, acute radiation syndromes, and problems with circulation and the central nervous system.. Typical risk models, including those used by NASA, assume radiation cancers are caused by DNA damage and mutations. These models, however, are based on much shorter times than a Mars mission would require, researchers noted.. Exploring Mars will require missions of 900 days or longer and includes more than one year in deep space where exposures to all energies of galactic ...
Soligenix, Inc., a Princeton, N.J.-based biopharmaceutical company, announced on Sunday that the U.S. Food and Drug Administration reviewed and approved its investigational new drug application for its gastrointestinal acute radiation syndrome drug.
Purpose: Studies of the association between ataxia telangiectasia-mutated (ATM) gene polymorphisms and acute radiation injuries are often small in sample size, and the results are inconsistent. We conducted the first meta-analysis to provide a systematic review of published findings. Methods and Materials: Publications were identified by searching PubMed up to April 25, 2014. Primary meta-analysis was performed for all acute radiation injuries, and subgroup meta-analyses were based on clinical endpoint. The influence of sample size and radiation injury incidence on genetic effects was estimated in sensitivity analyses. Power calculations were also conducted. Results: The meta-analysis was conducted on the ATM polymorphism rs1801516, including 5 studies with 1588 participants. For all studies, the cut-off for differentiating cases from controls was grade 2 acute radiation injuries. The primary meta-analysis showed a significant association with overall acute radiation injuries (allelic model: ...
The purpose of the present study was twofold: (1) to determine if X-irradiation can be considered a direct stress agent, and if so, to what extent it differs from other stressors; and (2) to further elucidate the role of the adrenal cortex in the radiation syndrome by determining the more immediate responses of this system to X-irradiation.
56 representatives of 34 global organisations have come together to reach consensus on the management of endometriosis, published in Human Reproduction.
While the concept of brain death is widely accepted, no universal criteria exist for its determination. This study compared guidelines from 80 countries finding that all standards specified exclusion of confounders, irreversible coma, absent motor response, and lack of brain-stem reflexes (see Wijdicks, "The Diagnosis of Brain Death" for more information). The majority of countries had medical practice standards (88%), legal standards (69%), utilized some form of apnea testing (59%), and required more than one physicians declaration (50%). Specifics varied widely on the qualifications of the physician, methods of apnea testing, and observation time before pronouncement of death. Regional differences were also noted, such as mandatory laboratory tests in Europe and Asia. Within the United States, brain death determination has been left to each state to decide (44 states and the District of Columbia have guidelines) whereas most African countries do not. Even if guidelines are not standardized, ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The threat of bioterrorism, long ignored and denied, has heightened over the past few years. Recent events in Iraq, Japan, and Russia cast an ominous shadow. Two candidate agents are of special concern: smallpox and anthrax. The magnitude of the problems and the gravity of the scenarios associated with release of these organisms have been vividly portrayed by two epidemics of smallpox in Europe during the 1970s and by an accidental release of aerosolized anthrax from a Russian bioweapons facility in 1979. Efforts in the United States to deal with possible incidents involving bioweapons in the civilian sector have only recently begun and have made only limited progress. Only with substantial additional resources at the federal, state, and local levels can a credible and meaningful response be mounted. For longer-term solutions, the medical community must educate both the public and policy makers about bioterrorism and build a global consensus condemning its use.
There is growing global consensus that the Information and communication technologies (ICTs), and particularly Internet are providing a new framework and huge opportunities for economic, political and social development. The World Summit for Social Development (WSSD, Copenhagen, 1995) recognized that the new information technologies and new approaches to access to and use of technologies by people living in poverty can help in fulfilling social development goals; and therefore recognize the need to facilitate access to such technologies. WSSD emphasized that promoting access for all to education, information, technology and know-how is an essential means for enhancing communication and participation in civil, political, economic, social and cultural life, and for ensuring respect for civil, political, economic, social and cultural rights. The World Summit on the Information Society (WSIS), Geneva 2003 - Tunis 2005, the Copenhagen Declaration and Tunis Commitment all recognized that ICTs is a key to
The National Institute of Allergy and Infectious Diseases (NIAID), an institute within the NIH, is hoping to stave off the rise of the mutant zombies in th
The expanded Center for Innovation in Advanced Development and Manufacturing (CIADM) in Baltimore helps the Nations pandemic preparedness.
CLT-008 is developed by the U.S. Food and Drug Administration Animal Rule for ARS. This approval pathway is available when human efficacy studies are neither ethical nor feasible and requires […]. ...
TOWNSEND: Well, the FDA Advisory Committee meets next week in this public hearing. Chimerix will be at it. If Chimerix can get their drug together, they can compete for it. They will look at the animal rule and the testing thats been -- thats gone on. And by the way, we talk about $433 million contract. If you look at the contract, you will see there are a number of milestones that the Siga as a company and the drug, SD-246, must meet in order to get payments along the way. This is not a guaranteed -- $433 million contract ...
A new $17 million research center dedicated to identifying medical countermeasures for neurotoxic chemicals that cause seizures in humans has been established by the U.S. National Institutes of Health at the University of California, Davis.
Lexapro and Migraine Headaches - Depression Home PageThis part of the. but I ciprofloxacin permanent side effects did increase my medication for that around.Classically acute radiation syndrome is divided into three main presentations:. very large skin doses can cause permanent hair loss, damaged sebaceous and sweat.. Pfenninger: Effects of menopause on hair By the Midland Daily News. was more hair loss over the entire body. permanent hair reduction.Inch Loss; Ultra Sound Cavitation; Cryo Lipo Fat Loss;. Diode Laser hair removal is one of the most comfortable procedures for permanent hair removal.. Melancholy, loss of energy, difficulty concentrating and suicidal thoughts. Permanent Vision. Loss. Lexapro in string position to become no. 1 brand in the ...
TY - JOUR. T1 - Kyoto global consensus report on Helicobacter pylori gastritis. AU - faculty members of Kyoto Global Consensus Conference. AU - Sugano, Kentaro. AU - Tack, Jan. AU - Kuipers, Ernst J.. AU - Graham, David Y.. AU - El-Omar, Emad M.. AU - Miura, Soichiro. AU - Haruma, Ken. AU - Asaka, Masahiro. AU - Uemura, Naomi. AU - Malfertheiner, Peter. AU - Azuma, Takeshi. AU - Bazzoli, Franco. AU - Chan, Francis Ka Leung. AU - Chen, Minhu. AU - Chiba, Naoki. AU - Chiba, Tsutomu. AU - Vas Coelho, Luiz Gonzaga. AU - Di Mario, Francesco. AU - Fock, Kwong Ming. AU - Fukuda, Yasuhiro. AU - Genta, Robert Maximilian. AU - Goh, Khean Lee. AU - Katelaris, Peter Harry. AU - Kato, Mototsugu. AU - Kawai, Takashi. AU - Kushima, Ryuji. AU - Mahachai, Varocha. AU - Matsuhisa, Takeshi. AU - Miwa, Hiroto. AU - Murakami, Kazunari. AU - OMorain, Colm Antoine. AU - Rugge, Massimo. AU - Sato, Kiichi. AU - Shimoyama, Tadashi. AU - Sugiyama, Toshiro. AU - Suzuki, Hidekazu. AU - Yagi, Kazuyoshi. AU - Wu, Ming ...
The purpose of this study was to investigate whether a relationship exists between alterations of the blood-brain barrier (BBB) and the survival time of rats exposed to supralethal irradiation. BBB alterations were produced by injection of glycerol, mercuric chloride, or by lymphatic cervical blockade. Animals were subsequently exposed to a supralethal dose of radiation, and the survival times of various groups were compared. The production of BBB alterations prior to irradiation did not influence the survival time of rats after exposure to supralethal doses of radiation suggesting that BBB damage may bear no direct relationship to the survival time after radiation injury. (Author)
Approval was granted by the Peter MacCallum Cancer Centre Institutional Ethics committee to conduct this retrospective study. Criteria for inclusion of patient data in the study included a pathological confirmation of NSCLC and treatment with concurrent chemotherapy and radical or high dose palliative radiotherapy at the Peter MacCallum Cancer Centre (East Melbourne campus). Exclusion criteria included previous thoracic RT, inconsistent radiation dose per fraction and hyper-fractionated radiation schedules. We also excluded patients with RT treatment interruptions ≥ 5 days, as mucosal recovery during the break may have confounded interpretation of the relationship between the oesophageal dose volume metrics and grade of oesophagitis.. Patient characteristics, treatment and toxicity data were extracted from paper and electronic medical records. Clinical data included the use of nasogastric (NG) or percutaneous endoscopic gastrostomy (PEG) tube, systemic steroids, proton pump inhibitors (PPI) ...
We offer clinical cancer updates, treatment guidance, and research news to the oncology nursing community. Visit us often for drug therapy testing results, patient care information and more. Download our FREE app today.
Acute Radiation Syndrome. Bradycardia[edit]. Main articles: Bradycardia and Athletic heart syndrome ... "Influence of heart rate on mortality after acute myocardial infarction". The American Journal of Cardiology. 65 (9): 547-53. ...
Filgrastim ('Neupogen') a hematopoietic countermeasure of acute radiation syndrome (ARS). Pegfilgrastim ('Neulasta') longer ... "Radiation Protection by a New Chemical Entity, Ex-Rad: Efficacy and Mechanisms". Radiation Research. 171 (2): 173-9. doi: ... This newly developed compound is said to be a potent radiation protection agent.[citation needed] Chemically, it is the sodium ... Onconova suggests that Ex-Rad protects cells exposed to radiation against DNA damage, and that the drug's mechanism of action ...
A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations. „Blood". 95 (12), s. 4011-3 ... acute myeloid leukemia lub acute myelogenous leukemia, AML lub acute non-lymphoblastic leukemia, ANLL) - grupa chorób ... Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias. „Semin Hematol". 39 (2), s. 128-33, Apr ... Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's ...
Despite this, there were no deaths caused by acute radiation syndrome. Given the uncertain health effects of low-dose radiation ... No radiation-related deaths or acute diseases have been observed among the workers and general public exposed to radiation from ... 12 April 2011 'Now radiation in Japan is as bad as radiation level is raised to 7 for only the second time in history' Daily ... among them that this figure was based on an assumption of acute deaths from low radiation doses. There is no known mechanism ...
This can cause acute radiation syndrome to the people around the area. The mission critical is a business's quintessence and if ...
Examples are: radiation burns, acute radiation syndrome, chronic radiation syndrome, and radiation-induced thyroiditis. ... High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled ... but no cases of acute radiation syndrome), popularized the warnings of occupational health associated with radiation hazards. ... Eben Byers, a famous American socialite, died of multiple cancers (but not acute radiation syndrome) in 1932 after consuming ...
Died 25 days after the accident of acute radiation syndrome, haematopoietic focus [10]. ... died 9 days after the accident of acute radiation syndrome, gastrointestinal focus [11]. ... He quickly moved the brick off the assembly, but received a fatal dose of radiation. He died 25 days later from acute radiation ... "Acute Radiation Sickness". Tripod. Retrieved August 12, 2015.. *^ a b "A Review of Criticality Accidents" (PDF). Los Alamos ...
Intake of very large amounts of radioactive material can cause acute radiation syndrome (ARS) in rare instances. Examples ... In summary, not all radiation is harmful. The radiation can be absorbed through multiple pathways, varying due to the ... The radiation risk proposed by the International Commission on Radiological Protection (ICRP) predicts that an effective dose ... The most harmful way to absorb radiation is that of absorption because it is almost impossible to control how much will enter ...
Radiation belt a new line of defence in nuclear emergency Reuters.com "Acute Radiation Syndrome: Fact Sheet for Physicians". ... engineers who were first on the scene died from high doses of gamma radiation in an illness known as Acute Radiation Syndrome ( ... Existing shielding is therefore incapable of preventing the acute health effects of exposure to gamma radiation (i.e. Acute ... For the body to recover from the acute health effects of radiation, it is important to allow crucial biological regenerative ...
National Institutes of Health is currently evaluating Pluristem's PLX-R18 cells as a treatment for acute radiation syndrome. ... were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and ... "Mitigation of Lethal Radiation Syndrome in Mice by Intramuscular Injection of 3D Cultured Adherent Human Placental Stromal ... PLX-R18 can serve as a tool for governments to protect their citizens against potential exposure to nuclear radiation. The ...
During the process of her work she got sick with acute radiation syndrome, and some time after that she is dead. Maria Orbeli ...
Ben becomes ill and dies of acute radiation syndrome: Danny and Kim bury him in the garden of an empty house. Inside the house ... In the months after the raid, all of the newly planted crops fail due to radiation damage. Kim's sister Maureen has become ... The narrative begins on a hillside, where the protagonist, Danny Lodge, encounters a man in a radiation suit, who confiscates ...
List of books about nuclear issues Nuclear or Not? Environmental impact of nuclear power Acute Radiation Syndrome Flowers, Sir ... "Radiation: Alpha Particles". US Environmental Protection Agency. EPA. Retrieved 7 November 2014. "Radiation: Beta Particles". ... The focus of the first half of the chapter is designed to provide basic information about atoms and radiation to aid in later ... It begins by accepting that the hazards of ionizing radiation are well appreciated by anyone who works in the field and that ...
... not acute radiation syndrome.[4][7] He is buried in Allegheny Cemetery in Pittsburgh, Pennsylvania, in a lead-lined coffin.[5] ... His death on March 31, 1932, was attributed to "radiation poisoning" using the terminology of the time, but it was due to ... He earned notoriety in the early 1930s when he died from multiple radiation-induced cancers after consuming a popular patent ... "A Little Poison Can Be Good For You The received wisdom about toxins and radiation may be all wet". Fortune. Retrieved June 22 ...
... and development of products with the potential to treat cancer and protect against death following acute radiation syndrome. ... It is being developed both as a radiation countermeasure and as a cancer treatment. Entolimod is being developed and tested in ... Entolimod acts through activation of Toll-like Receptor 5 to mobilize antitumor immune response and reduce radiation effects on ... two contexts: as an anti-radiation pharmaceutical, under the U.S. Food and Drug Administration's Animal Efficacy Rule, without ...
Akimov died two weeks after the accident due to acute radiation syndrome, also known as radiation poisoning, at the age of 33. ...
... design problem was the need for heavy shielding to protect the crew and those on the ground from acute radiation syndrome; ... The main purpose of the flight phase was examining the effectiveness of the radiation shielding, which was one of the main ... In 1957, the Air Force and the U.S. Atomic Energy Commission contracted with the Lawrence Radiation Laboratory to study the ... Massive protection so reduced radiation levels that development could continue, but, as in the US, it ceased. The obvious ...
... or in acute radiation syndrome (though deuterium is not radioactive), and is due to deuterium's action in generally inhibiting ... Heavy water radiation contamination confusion[edit]. Although many people associate heavy water primarily with its use in ... SNO detects the Cherenkov radiation in the water from high-energy electrons produced from electron-type neutrinos as they ... but rather radiation poisoning from other isotopes in the heavy water. Some news services were not careful to distinguish these ...
... the report states that 28 emergency workers died from acute radiation syndrome and 15 patients died from thyroid cancer. It ... The report also concluded that a greater risk than the long-term effects of radiation exposure, is the risk to mental health ... United Nations Scientific Committee on the Effects of Atomic Radiation) the WHO (World Health Organization) the World Bank. The ... Since most emergency workers and people living in contaminated areas received relatively low radiation doses, comparable to ...
"Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched ... "The radiation protection and therapy effects of mesenchymal stem cells in mice with acute radiation injury". The British ... Huisheng Ai (Chinese: 艾辉胜, born in 1958) is the current director of both the Hematology and Radiation Therapy Departments of ... After a short time working in various departments, he settled in the radiation and homeopathy departments, the most revered in ...
Radiation exposure can produce effects ranging from skin redness and hair loss, to radiation burns and acute radiation syndrome ... EPA - Radionuclides - EPA's Radiation Protection Program: Information. FDA - Radionuclides - FDA's Radiation Protection Program ... In food preservation, radiation is used to stop the sprouting of root crops after harvesting, to kill parasites and pests, and ... This excess energy can be used in one of three ways: emitted from the nucleus as gamma radiation; transferred to one of its ...
The deterministic effects that can lead to acute radiation syndrome only occur in the case of high doses (> ~10 rad or > 0.1 Gy ... Doses greater than 100 rem received over a short time period are likely to cause acute radiation syndrome (ARS), possibly ... Office of Radiation and Indoor Air (May 2007). "Radiation: Risks and Realities" (PDF). Radiation: Risks and Realities. U.S. ... "How to Understand and Communicate Radiation Risk". Image Wisely. Retrieved 18 May 2012. Effects of ionizing radiation : UNSCEAR ...
Some 50 emergency workers died of acute radiation syndrome, nine children died of thyroid cancer and an estimated total of 3940 ... An UNSCEAR report places the total confirmed deaths from radiation at 64 as of 2008. The eventual death toll could reach 4,000 ... died from radiation-induced cancer and leukemia. Hanford Nuclear, 1986 - The U.S. government declassifies 19,000 pages of ...
Radiation poisoningEdit. Main article: acute radiation syndrome. Radiation poisoning, also called "radiation sickness" or a " ... a b c d e f g h i j k l m n o p q Coggle, J.E., Lindop, Patricia J. "Medical Consequences of Radiation Following a Global ... There are numerous lethal radiation syndromes, including prodromal syndrome, bone marrow death, central nervous system death ... The term is generally used to refer to acute problems caused by a large dosage of radiation in a short period, though this also ...
... including Acute radiation syndrome Radiation burns Radiation-induced cancer Radiation-induced heart disease Radiation-induced ... Somatic damage may refer to any of the health effects of radiation other than teratogenesis, ... lung injury Radiation-induced thyroiditis Radiation induced cognitive decline Or Released track of Audio Junkz. ...
Acute respiratory distress syndrome (ARDS), alveolar hemorrhage, and allergic reactions (usually expressed in first 30 minutes ... p. 96, "Radiation doses were intense, being estimated at 205, 320, 410, 415, 422, and 433 rem. Of the six persons present, one ... Acute graft-versus-host disease typically occurs in the first 3 months after transplantation and may involve the skin, ... However, it is less effective in rapidly growing acute leukemias.[38] If cancer relapses after HSCT, another transplant can be ...
Antonyms for Acute radiation syndrome. 7 synonyms for syndrome: condition, complaint, illness, symptoms, disorder, ailment, ... Synonyms for Acute radiation syndrome in Free Thesaurus. ... Acute radiation syndrome synonyms, Acute radiation syndrome ... "Pulmonary Acute Radiation Syndrome" or "Lung-ARS") as well as the gastrointestinal sub-syndrome of acute radiation syndrome (" ... syndrome. (redirected from Acute radiation syndrome). Also found in: Dictionary, Medical, Acronyms, Encyclopedia, Wikipedia. # ...
Information on acute radiation syndrome, its symptoms and treatment. Provided by the Centers for Disease Control and Prevention ... Acute Radiation Syndrome (ARS), or radiation sickness, is a serious illness that can happen when a person is exposed to very ... Radiation Dictionary. *Radiation Emergencies & Your Healthplus icon *Possible Health Effectsplus icon *Contamination and ... Cutaneous Radiation Injury (CRI) happens when exposure to a large dose of radiation causes injury to the skin. A doctor will ...
The Acute Radiation Syndrome. Br Med J 1952; 2 doi: https://doi.org/10.1136/bmj.2.4790.925 (Published 25 October 1952) Cite ...
It is being developed as a radiation countermeasure to prevent death from Acute Radiation Syndrome (ARS). ARS would be a major ... Cleveland Biolabs Countermeasure for Acute Radiation Syndrome, Pipeline Review, and Market Potential. ... The market for radiation countermeasures has grown substantially, primarily due to the perceived threat of chemical, biological ... Due to the limitations of the two currently approved treatments to deal with a large-scale radiation event, CBLI believes that ...
... as a treatment for the pulmonary syndrome of acute radiation syndrome (Lung-ARS) and delayed effects of acute radiation ... Home News BARDA Exercises $6M Option for Aeolus Acute Radiation Syndrome Drug ... BARDA Exercises $6M Option for Aeolus Acute Radiation Syndrome Drug. September 18, 2013. 0 ...
Acute Radiation Syndrome / Death Online converter page for a specific unit. Here you can make instant conversion from this unit ... Instant Conversion for Units of Radiation. Radiation Converter. Acute radiation syndrome.. Copyright © 1996-2019 by Sergey ... This is a conversion chart for death (Acute radiation syndrome). To switch the unit simply find the one you want on the page ... Absorbed and equivalent radiation doses can not be directly converted as the conversion depends on the type of radiation. On ...
Acute radiation syndrome (ARS), also called radiation sickness, is the result caused by receiving a dose greater than 75 rads ( ... Acute Radiation Syndrome: A Fact Sheet for Physicians. *↑ 3.0 3.1 3.2 3.3 Waselenko,JK et al. (15 June 2004), "Medical ... Other radiation syndromes can be caused by localized radiation, or a cumulative whole-body exposure over a length of time (e.g ... Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group", ...
Acute radiation syndrome (ARS) also known as radiation poisoning, radiation sickness or radiation toxicity, is a syndrome or ... "Acute Radiation Syndrome" (PDF). National Center for Environmental Health/Radiation Studies Branch. 2002-04-09. Retrieved 2009- ... June 2010). "Acute radiation syndrome: assessment and management". South. Med. J. 103 (6): 541-6. doi:10.1097/SMJ. ... "Acute Radiation Syndrome: A Fact Sheet for Physicians". Centers for Disease Control and Prevention. 2005-03-18.. ...
ARS occurs when the body is exposed to radiation in excess of four sieverts (the biological dose equivalent of radiation). The ... Affects of acute radiation syndrome (ARS), computer artwork. ... Acute radiation syndrome. M108/0775 Rights Managed. Request low ... Caption: Affects of acute radiation syndrome (ARS), computer artwork. ARS occurs when the body is exposed to radiation in ... Keywords: acute radiation syndrome, adult, artwork, bone, bone marrow, bones, brain, cerebral, concept, concepts, conceptual, ...
Radiation Sickness, Acute Radiation Syndrome) Market Size, Status and Forecast 2025 to its huge collection of research reports ... Radiation Sickness, Acute Radiation Syndrome). 1.1 Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome) Market ... Acute Radiation Syndrome) Competition Analysis by Players. 2.1 Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome ... Acute Radiation Syndrome) market, analyzes and researches the Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome ...
Acute radiation syndrome. Illnesses collectively called acute radiation syndrome occur within a few hours to months after ... Stram DO, Mizuno S: Analysis of the DS86 atomic-bomb radiation dosimetry using data on severe epilation. Radiation Research ... If the radiation dose is low, the syndrome will seldom if ever occur. Conversely, if the dose is high, death can occur within ... The Figure shows the relation of severe epilation (loss of more than 2/3 of scalp hair) to radiation dose. Although there is ...
... plant accident has prompted rethinking of the contingency plan for prophylaxis and treatment of the acute radiation syndrome ( ... in acute radiation injury has become standard treatment for ARS in the United States, based on the fact that growth factors ... After radiation exposure to the lungs, resting macrophages can no longer be transformed, not even during systemic ... However, GM-CSF is not expressed in radiation injured tissue due to defervescence of the macrophages. In order to maintain the ...
... in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or ... this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. ... G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be ... anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with ...
During such an attack, people could suffer from the acute radiation syndrome. This syndrome is the collection of bodily effects ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ... Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group ...
... regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). The FDA provided Pluristem ... Pluristem Concludes Positive Meeting with FDA on Development Plan for Acute Radiation Syndrome. ... regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). The FDA provided Pluristem ... These studies demonstrated PLX-R18 potential to increase survival rates after radiation exposure, as well as protect and ...
Placental Cells Found to Have Potential to Mitigate Acute Radiation Syndrome. Monday, Oct 24 2011Acute Radiation Syndrome (ARS).. During the studies, animals were injected ... "While our experiments using PLX cells in treating radiation exposure are ongoing and still evolving, these initial data are ... post radiation treatment, which could potentially be used in the future for treating ARS patients. ...
... and acute myelogenous leukemia (AML) risk associated with radiation and/or chemotherapy breast cancer (BC) treatment. Our study ... those treated with radiation and those treated with radiation and chemotherapy compared to available population incidence data ... A RR of 3.32 (95% CI = 1.42, 6.45) was observed in the surgery/radiation-only group and a RR of 6.32 (95% CI = 3.03, 11.45) in ... 5790 TNM stage 0-III patients treated with surgery alone, radiation and/or chemotherapy were included. Patients without surgery ...
Treatment Acute radiation syndrome. Symptoms and causes Acute radiation syndrome Prophylaxis Acute radiation syndrome ... Acute radiation syndrome». *. CDC Radiation Emergencies , Acute Radiation Syndrome. Acute Radiation Syndrome (ARS): A Fact ... Acute Radiation Syndrome: A Fact .... Acute Radiation Syndrome: A Fact Sheet for Physicians. Acute Radiation Syndrome (ARS) ( ... Acute radiation syndrome definition - Medical Dictionary .... Acute radiation syndrome: An acute illness caused by a dose ...
... biological effects of ionising radiation or radiobiology - experimental studies (dosimetry, reactor physics, radiochemistry), ... Chronic Myelogenic Leukemia, Developed at the Survivor of Acute Radiation Syndrome Severe Degree. N. Nadezhina1, I. Galstyan1, ... sufficient for leading of the first results of supervision of the acute radiation syndrome (ARS) survivors. Among 10 patients ... The most typical is development of acute leukemia and chronic myelogenic leukemia 5-10 years later radiation exposure.. At the ...
... biological effects of ionising radiation or radiobiology - experimental studies (dosimetry, reactor physics, radiochemistry), ... Immunoglobulines to Radiation Toxins were used for a treatment of Acute Radiation Syndromes and the efficacy of this bio- ... Medical management of Acute Radiation Syndromes:Immunotherapy by Antiradiation Immunoglobulin G .. D. Popov1 and V. Maliev2 ... Differential diagnosis of Acute Radiation Syndromes by Enzyme Immune-Assay (EIA) Radioprotection 2008, Vol. 43, n° 5. ...
... a potential therapy for Acute Radiation Syndrome, has been granted Orphan Drug Designation by the U.S. Food and Drug ... Enzychem Lifesciences has announced that EC-18, a potential therapy for Acute Radiation Syndrome (ARS), has been granted Orphan ... Orphan Drug Designation Granted to Potential Acute Radiation Syndrome Treatment. JANUARY 22, 2018 ... ARS is developed after a patient is exposed to high amounts of radiation in a short period of time, breaking down immature ...
Filed Under: New Publications Tagged With: ER beta, ERb, ERβ, estrogen receptor, H-ARS, hematopoietic-acute radiation syndrome ... Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome. ... drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic-acute radiation syndrome (H-ARS). ... Date of publication: 30 April 2019; Journal of Radiation Research. Author information: Michael R. Landauer (1); Adam J. Harvey ...
... is the medical term for the damage occurring to the body after exposure to large amount of radiation within a short period of ... time (24 hours). Know the causes, signs, symptoms, treatment and diagnosis of Acute Radiation Syndrome. ... Other names for Acute Radiation Syndrome are: Acute Radiation Sickness, Radiation Sickness, Radiation Poisoning and Radiation ... Acute Radiation Syndrome consists of the following sub syndromes:. Hematopoietic Syndrome: In this category of acute radiation ...
Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group ... Also called radiation poisoning, radiation toxicity, or radiation sickness.. *Acute illness caused by exposure to high doses ( ... Acute radiation syndrome. Revision as of 05:54, 22 June 2018 by Rossdonaldson1. (talk , contribs) (→‎External Links) ... Acute radiation syndrome: assessment and management. South Med J. 2010 Jun;103(6):541-6. ...
  • Soligenix is also developing OrbeShield(TM) for the treatment of gastrointestinal acute radiation syndrome (GI ARS) under a BARDA contract award valued up to $26. (freethesaurus.com)
  • In response to an invitation from the Biomedical Advanced Research and Development Authority (BARDA), we submitted a contract proposal to support the development of OrbeShield (TM) for the treatment of gastrointestinal acute radiation syndrome (GI ARS), which if awarded, has the potential to be a multi-million dollar contract. (freethesaurus.com)
  • Her research has spanned drug discovery, preclinical development, manufacturing and clinical development in indications such as acute radiation syndrome , inflammation, infectious disease, cancer and cancer supportive care. (freethesaurus.com)
  • WASHINGTON -- Two contracts for advanced development of drugs to treat skin and lung injuries associated with acute radiation syndrome (ARS) were awarded this week by the U. (freethesaurus.com)
  • Support for OrbeShield(TM) product development is being provided under a CBRN program to advance technologies and products to treat acute radiation syndrome (ARS). (freethesaurus.com)
  • The SNS assembled a working group with representatives from the Centers for Disease Control and Prevention, the U.S. Armed Forces, and universities with expertise in acute radiation injury. (annals.org)
  • Visit the U.S. Centers for Disease Control and Prevention (CDC) for more information about possible health effects of radiation exposure and contamination. (epa.gov)
  • Centers for Disease Control and Prevention (2005) Cutaneous radiation injury: fact sheet for physicians. (springer.com)
  • These studies demonstrated PLX-R18 potential to increase survival rates after radiation exposure, as well as protect and regenerate the bone marrow's ability to produce blood cells, crucial for victims exposed to high levels of radiation. (apnews.com)
  • Exposure to low levels of radiation encountered in the environment does not cause immediate health effects, but is a minor contributor to our overall cancer risk. (epa.gov)
  • Exposure to low-levels of radiation does not cause immediate health effects, but can increase the risk of cancer over a lifetime. (epa.gov)
  • Injection of PLX-R18 cells into muscle, as compared to a placebo , resulted in a statistically significant improvement in the recovery of white blood cell, red blood cell, and platelet levels in animals exposed to high levels of radiation. (medicalnewstoday.com)
  • High levels of radiation can destroy the body's ability to produce these three blood lineages, and rapidly regaining that capacity is a key factor in surviving the hematologic component of acute radiation syndrome (ARS), a condition caused by high-dose irradiation that can involve severe, sometimes lethal damage to the bone marrow as well as other physiologic systems and organs. (medicalnewstoday.com)
  • Our PLX-R18 cell product was developed and targeted to become a strong candidate for government procurement programs designed to protect the population in the case of exposure to dangerous levels of radiation. (medicalnewstoday.com)
  • The data demonstrate improved survival and hematological recovery of NHPs exposed to different levels of radiation. (globenewswire.ca)
  • These findings, which show recovery of the hematologic system, suggest that PLX-R18 has the potential to treat a large population exposed to different levels of radiation and might also be used for additional hematologic indications. (globenewswire.ca)
  • For example, Pluristem is using forward-looking statements when its discusses that PLX-R18 has the potential to treat a large population exposed to different levels of radiation and might also be used for additional hematologic indications, and the potential market for such indications. (globenewswire.ca)
  • The scientists say that exposure to higher levels of radiation raises lifetime cancer risk 'slightly' . (medicalnewstoday.com)
  • Exposure to low levels of radiation in the environment does not cause immediate health effects. (medlineplus.gov)
  • The entire body (or a significant portion of it) must have received the dose.3 o Most radiation injuries are local, frequently involving the hands, and these local injuries seldom cause classical signs of ARS. (cdc.gov)
  • For example, Pluristem is using forward-looking statements when it states its belief that, as a result of its meeting with the FDA, it has a clear and efficient path towards advancing the development of PLX-R18 in the treatment of ARS and its potential support of the U.S. government with respect to its medical needs relating to radiation injuries. (apnews.com)
  • At development leukemia at ARS survivors, "hyperregeneration" - hemopoesis with increasing of neutrophils amount (in the absence of consequences of local radiation injuries) within the first years after an irradiation can form a basis for leukogenic transformation. (radioprotection.org)
  • Cell technologies for replacement of skin defects at the patient with local radiation injuries. (radioprotection.org)
  • Colwell CB: Radiation injuries, in Marx JA, Hockberger RS, Walls RM, et al (eds): Rosen's Emergency Medicine: Concepts and Clinical Practice, ed 8. (wikem.org)
  • WASHINGTON -- Two contracts for advanced development of drugs to treat skin and lung injuries associated with acute radiation syndrome (ARS) were awarded this week by the U. (freethesaurus.com)
  • A clear attribution of causes of death to burns, injuries or radiation was impossible because the shock and heat waves also had to be taken into account. (bfs.de)
  • Our novel approach of DRCC transplantation may act as a bridging therapy supporting hematopoietic recovery and ameliorating injuries in patients exposed to the harmful effects of radiation. (ps-rc.org)
  • Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs. (iu.edu)
  • Berger ME, Christensen DM, Lowry PC et al (2006) Medical management of radiation injuries: current approaches. (springer.com)
  • In the third of 5 articles on the management of injuries and illnesses caused by ionizing radiation, the authors provide a clinically relevant overview of the pathophysiologic process associated with potential exposure to ionizing radiation. (jaoa.org)
  • To appreciate the systemic pathophysiologic process of ionizing radiation injuries and illnesses, it is necessary to understand how ionizing radiation causes subcellular, cellular, tissue, and organ damage. (jaoa.org)
  • The TBI dose ranges against which sLP are effective indicate that sLP primarily impact the hematopoietic (HP) component of acute radiation syndrome. (elsevier.com)
  • People who receive a single large dose of 1,000 millisieverts of radiation to the total body can expect to experience acute radiation syndrome, characterized by changes in blood count, nausea, vomiting and diarrhea. (go.com)
  • The new data were to be used to test the triage scheme that had been developed by Thoma and Wald in 1959 to provide clinicians without any special knowledge about radiation effects with early diagnostic and prognostic information about the severity of such injury as a basis for medical management. (cdc.gov)
  • The amount of radiation that a person's body absorbs is called the radiation dose. (cdc.gov)
  • Acute Radiation Syndrome (ARS) is the medical term for the damage occurring to the body after exposure to large amount of radiation within a short period of time (24 hours). (epainassist.com)
  • The amount of damage and the type of damage to the body depends on the dose and amount of radiation absorbed by the body. (epainassist.com)
  • The amount of radiation absorbed in turn depends on the dose or the strength of the radiation and the distance between the source of radiation and the patient. (epainassist.com)
  • The diagnostic imaging tests such as an x-ray only use small amount of radiation, which is usually below 0.1 Gy and that too the radiation is focused on small amount of tissue or organs. (epainassist.com)
  • rad The U.S. unit used to measure absorbed radiation dose (the amount of radiation absorbed by an object or person). (epa.gov)
  • The amount of radiation absorbed by the body - the absorbed dose - determines how sick you'll be. (pharmacypedia.org)
  • The BfS says the maximum amount of radiation allowed from the DECT telephones by the International Commission for the Protection of Non-ionized Radiation is too high. (medindia.net)
  • Base stations and the handset send out the same amount of radiation during a telephone call regardless of the user's distance from the base station. (medindia.net)
  • You would need to go through a full-body airport scanner about 1,000 times to get the same amount of radiation that you would get from 1 chest X-ray. (uwhealth.org)
  • If you are concerned about the risk of getting cancer from having a CT scan, talk to your doctor about the amount of radiation this test may give you. (uwhealth.org)
  • But the amount of radiation exposure from one of these scanners is very low. (uwhealth.org)
  • At the present time, Intravenous Immunoglobulins are used for an efficient therapy for immune deficiency syndromes, thrombocytopenias, inflammatory reactions, modulation of autoimmunity and a wide range of hematologic disorders. (radioprotection.org)
  • The SNS developed recommendations to help health care professionals respond appropriately in the event of an attack involving radiation exposure. (annals.org)
  • HAIFA, Israel, Jan. 03, 2019 (GLOBE NEWSWIRE) -- Pluristem Therapeutics Inc. (Nasdaq:PSTI) (TASE:PSTI), a leading regenerative medicine company developing novel placenta-based cell therapy products, today announced it has concluded a positive meeting with the U.S. Food and Drug Administration (FDA) regarding the ongoing development of PLX-R18 for the treatment of Acute Radiation Syndrome (ARS). (apnews.com)
  • Traditionally, the treatment of Acute Radiation Syndromes (ARS) includes supportive therapy, cytokine therapy, blood component transfusions and stem cell transplantation. (radioprotection.org)
  • Treatment of acute radiation syndrome consists of supportive therapy with blood transfusions, antibiotics to combat infection. (epainassist.com)
  • Treatment of acute radiation syndrome is generally supportive care . (mdwiki.org)
  • Treatment of acute radiation syndrome is generally supportive with blood transfusions and antibiotics , with some more aggressive treatments, such as bone marrow transfusions, being required in extreme cases. (gutenberg.org)
  • PSTI ), a leading developer of placenta-based cell therapy products, announced today the company will present data from its Phase II-equivalent study of PLX-R18 cells for the treatment of acute radiation syndrome (ARS) at the American Society of Hematology's (ASH) 59th Annual Meeting to be held in Atlanta, Georgia, on December 9-12, 2017. (globenewswire.ca)
  • Dusquetide has previously received orphan drug designation for the treatment of acute radiation syndrome (ARS). (drugs.com)
  • Leukine is FDA-approved for the treatment of acute radiation syndrome (ARS) and is held in the Strategic National Stockpile. (prnewswire.com)
  • Radiation Neurotoxin isolated from lymphatic system of irradiated animals (with a clinical picture of cerebral radiation syndrome) and injected to healthy animals in toxic doses 0.03 mg/kg, 0.5 mg/kg, 10.0 mg/kg, 15.0 mg/kg had initiated development of acute failure of blood circulation and breathing ventilation. (radioprotection.org)
  • Her research has spanned drug discovery, preclinical development, manufacturing and clinical development in indications such as acute radiation syndrome , inflammation, infectious disease, cancer and cancer supportive care. (freethesaurus.com)
  • Estimate a patient's absorbed radiation dose (i.e., level of radiation exposure) based on information from public health authorities, biodosimetry if available, or clinical findings such as time to onset of vomiting or lymphocyte depletion kinetics. (drugs.com)
  • In: Ricks RC, Berger ME, O'Hara FM (eds) The medical basis for radiation accident preparedness: the clinical care of victims. (springer.com)
  • The initial focus of effort on the NIOSH ARS project, a component of Project 2.3, waS to add clinical information concerning the 59 accidentally radiation -exposed workers in the former Soviet Union during 1948 through 1958 to a similar number of accident cases collected in the Western world. (cdc.gov)
  • In view of the rarity of the syndrome, all 59 cases were prepared for further study in Project 2.3 A selection was therefore made of 77 clinical and laboratory items that were of most significance and likely to be on record in most cases. (cdc.gov)
  • Leukine has a proven safety profile and there is clinical evidence indicating that it could confer benefit to patients with acute hypoxemia from COVID-19 infection. (prnewswire.com)
  • The company's proprietary platform of toll-like immune receptor activators has applications in radiation mitigation, oncology immunotherapy, and vaccines. (yahoo.com)
  • Mice on flaxseed displayed improved survival rates and mitigation of radiation pneumonitis, with increased blood oxygenation levels, higher body weight, lower pro-inflammatory cytokine levels, and greatly reduced pulmonary inflammation and fibrosis. (medindia.net)
  • Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding. (iu.edu)
  • ARS is developed after a patient is exposed to high amounts of radiation in a short period of time, breaking down immature parenchymal stem cells in tissues due to the irradiation of the entire body. (raredr.com)
  • Acute myelosuppression is the primary cause of death after accidental or intentional exposure to a high dose of total body irradiation (TBI) [ 2 , 3 ]. (mdpi.com)
  • A level of 2.4mScv per year is what natural background radiation worldwide typically exposes us to. (medicalnewstoday.com)
  • Background radiation is all around us all the time. (medlineplus.gov)
  • Background radiation can also come from outer space and the sun. (medlineplus.gov)
  • Our cells can easily clean up any damage done by this low-level background radiation - on average Australians are exposed to about 1.5 millisievert (mSv) of background radiation a year - but it is a different story if you are exposed to doses greater than about 500 mSv. (abc.net.au)
  • Background radiation originates from a variety of sources, both natural and artificial. (wikipedia.org)
  • For example, in considering radiation safety , background radiation is defined by the International Atomic Energy Agency as "Dose or dose rate (or an observed measure related to the dose or dose rate) attributable to all sources other than the one(s) specified. (wikipedia.org)
  • However, if no specific radiation source is of concern, then the total radiation dose measurement taken at a location is generally called the background radiation , and this is usually the case where an ambient dose rate is measured for environmental purposes. (wikipedia.org)
  • The widespread construction of well insulated and sealed homes in the northern industrialized world has led to radon becoming the primary source of background radiation in some localities in northern North America and Europe. (wikipedia.org)