An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.
Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.
The concrete oleoresin obtained from Pinus palustris Mill. (Pinaceae) and other species of Pinus. It contains a volatile oil, to which its properties are due, and to which form it is generally used. (Dorland, 28th ed) Turpentine is used as a solvent and an experimental irritant in biomedical research. Turpentine toxicity is of medical interest.

Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist. (1/655)

The interleukin-1 (IL-1) receptor antagonist (IL-1ra) is an endogenous antagonist that blocks the effects of the proinflammatory cytokines IL-1alpha and IL-1beta by occupying the type I IL-1 receptor. Here we describe transgenic mice with astrocyte-directed overexpression of the human secreted IL-1ra (hsIL-1ra) under the control of the murine glial fibrillary acidic protein (GFAP) promoter. Two GFAP-hsIL-1ra strains have been generated and characterized further: GILRA2 and GILRA4. These strains show a brain-specific expression of the hsIL-1ra at the mRNA and protein levels. The hsIL-1ra protein was approximated to approximately 50 ng/brain in cytosolic fractions of whole brain homogenates, with no differences between male and female mice or between the two strains. Furthermore, the protein is secreted, inasmuch as the concentration of hsIL-1ra in the cerebrospinal fluid was 13 (GILRA2) to 28 (GILRA4) times higher in the transgenic mice than in the control animals. To characterize the transgenic phenotype, GILRA mice and nontransgenic controls were injected with recombinant human IL-1beta (central injection) or lipopolysaccharide (LPS, peripheral injection). The febrile response elicited by IL-1beta (50 ng/mouse icv) was abolished in hsIL-1ra-overexpressing animals, suggesting that the central IL-1 receptors were occupied by antagonist. The peripheral LPS injection (25 micrograms/kg ip) triggered a fever in overexpressing and control animals. Moreover, no differences were found in LPS-induced (100 and 1,000 micrograms/kg ip; 1 and 6 h after injection) IL-1beta and IL-6 serum levels between GILRA and wild-type mice. On the basis of these results, we suggest that binding of central IL-1 to central IL-1 receptors is not important in LPS-induced fever or LPS-induced IL-1beta and IL-6 plasma levels.  (+info)

Expression of serum amyloid A protein in the absence of the acute phase response does not reduce HDL cholesterol or apoA-I levels in human apoA-I transgenic mice. (2/655)

Plasma concentrations of high density lipoprotein (HDL) cholesterol and its major apolipoprotein (apo)A-I are significantly decreased in inflammatory states. Plasma levels of the serum amyloid A (SAA) protein increase markedly during the acute phase response and are elevated in many chronic inflammatory states. Because SAA is associated with HDL and has been shown to be capable of displacing apoA-I from HDL in vitro, it is believed that expression of SAA is the primary cause of the reduced HDL cholesterol and apoA-I in inflammatory states. In order to directly test this hypothesis, we constructed recombinant adenoviruses expressing the murine SAA and human SAA1 genes (the major acute phase SAA proteins in both species). These recombinant adenoviruses were injected intravenously into wild-type and human apoA-I transgenic mice and the effects of SAA expression on HDL cholesterol and apoA-I were compared with mice injected with a control adenovirus. Plasma levels of SAA were comparable to those seen in the acute phase response in mice and humans. However, despite high plasma levels of murine or human SAA, no significant changes in HDL cholesterol or apoA-I levels were observed. SAA was found associated with HDL but did not specifically alter the cholesterol or human apoA-I distribution among lipoproteins. In summary, high plasma levels of SAA in the absence of a generalized acute phase response did not result in reduction of HDL cholesterol or apoA-I in mice, suggesting that there are components of the acute phase response other than SAA expression that may directly influence HDL metabolism.  (+info)

C-reactive protein and outcome after ischemic stroke. (3/655)

BACKGROUND AND PURPOSE: Elevated concentrations of the acute-phase reactant C-reactive protein (CRP) predict ischemic cardiac events in both hospital- and population-based studies and may signify a role for inflammation in the destabilization of cardiovascular disease. We examined the relationship between CRP and outcome after acute ischemic stroke. METHODS: This was a subgroup analysis from a prospective observational study based in a University Hospital Acute Stroke Unit serving a population of approximately 260 000. Survival time and cause of death for up to 4 years after the index stroke were determined and related to CRP concentration within 72 hours of stroke and known prognostic variables by a Cox proportional hazards regression model. RESULTS: Ischemic stroke was diagnosed in 228 of 283 consecutive admissions. Median follow-up was 959 days. Geometric mean CRP concentration was 10.1 mg/L. Survival in those with CRP >10.1 mg/L was significantly worse than in those with CRP 10.1 mg/L and 63% of deaths in those with CRP +info)

Fish oil-enriched nutritional supplement attenuates progression of the acute-phase response in weight-losing patients with advanced pancreatic cancer. (4/655)

The presence of an acute-phase protein response (APPR) has been suggested to shorten survival and contribute to weight loss in patients with pancreatic cancer. Fatty acids derived from fish oil have been shown to alter proinflammatory cytokine production and acute-phase protein synthesis in vitro. The present study was designed to determine the effects of a fish oil-enriched nutritional supplement on the concentrations of a range of individual acute-phase proteins (APP) in patients with advanced pancreatic cancer. In a sequential series, 18 patients with pancreatic cancer received the supplement (providing 2 g eicosapentaenoic acid and 1 g docosahexaenoic acid/d) for 3 wk while another 18 received full supportive care alone. Six healthy subjects served as additional controls. Acute-phase proteins were measured before and after the 3-wk intervention period in cancer patients. At baseline, albumin, transferrin and pre-albumin were significantly reduced and fibrinogen, haptoglobin, alpha-1-acid glycoprotein, alpha-1-antitrypsin, ceruloplasmin and C-reactive protein (CRP) were significantly elevated in the cancer patients compared with healthy controls, reflecting their roles as negative and positive acute phase proteins, respectively. In the supplemented cancer group, the only significant change in APP concentrations over the 4-wk study period was an increase in transferrin. In the control cancer group there were further significant reductions in albumin, transferrin and pre-albumin, and a significant increase in CRP concentration. These results suggest that many positive and negative APP are altered in advanced pancreatic cancer. The APPR tends to progress in untreated patients but may be stabilized by the administration of a fish oil-enriched nutritional supplement. This may have implications for reducing wasting in such patients.  (+info)

SAA-only HDL formed during the acute phase response in apoA-I+/+ and apoA-I-/- mice. (5/655)

Serum amyloid A (SAA) is an acute phase protein of unknown function that is involved in systemic amyloidosis and may also be involved in atherogenesis. The precise role of SAA in these processes has not been established. SAA circulates in plasma bound to high density lipoprotein-3 (HDL3). The pathway for the production of SAA-containing HDL is not known. To test whether apolipoprotein (apo)A-I-HDL is required in the production of SAA-HDL, we analyzed the lipopolysaccharide (LPS)-induced changes in apoA-I+/+ and apoA-I-/- mice. In apoA-I+/+ mice, after injection of LPS, remodeling of HDL occurred: total cholesterol increased and apoA-I decreased slightly and shifted to lighter density. Dense (density of HDL3) but large (size of HDL2 ) SAA-containing particles were formed. Upon fast phase liquid chromatography fractionation of plasma, >90% of SAA eluted with HDL that was enriched in cholesterol and phospholipid and shifted "leftward" to larger particles. Non-denaturing immunoprecipitation with anti-mouse apoA-I precipitated all of the apoA-I but not all of the SAA, confirming the presence of SAA-HDL devoid of apoA-I. In the apoA-I-/- mice, which normally have very low plasma lipid levels, LPS injection resulted in significantly increased total and HDL cholesterol. Greater than 90% of the SAA was lipid associated and was found on dense but large, spherical HDL particles essentially devoid of other apolipoproteins.We conclude that serum amyloid A (SAA) is able to sequester lipid, forming dense but large HDL particles with or without apoA-I or other apolipoproteins. The capacity to isolate lipoprotein particles containing SAA as the predominant or only apolipoprotein provides an important system to further explore the biological function of SAA.  (+info)

Association of fatigue with an acute phase response in sarcoidosis. (6/655)

The pathophysiological explanation for fatigue, one of the most common symptoms in sarcoidosis, still has to be elucidated. It was hypothesized that the presence of fatigue is associated with an acute phase response in sarcoidosis. A cross-sectional study was performed in 38 sarcoidosis patients. Resting energy expenditure (REE) was measured in the fasting state by indirect calorimetry using a ventilated hood and adjusted for fat-free mass (FFM). Patients with fatigue (n=25) also suffered more frequently from other symptoms, such as exercise intolerance (p=0.01), the need for sleep (p=0.02) and weight loss (p=0.01), compared to those without fatigue (n=13). However, no relationship was found between fatigue and serum angiotensin-converting enzyme (sACE) or lung function impairment. Patients with fatigue had higher levels of C-reactive protein (CRP) (11.4+/-6.8 microg x mL(-1), p<0.0001) and REE adjusted for FFM (33.0+/-3.7 kcal x kg FFM(-1), p<0.003) compared to those without fatigue (3.2+/-2.2 mg x mL(-1); 29.2+/-2.8 kcal x kg FF(-1)). Furthermore, REE/FFM was significantly related to CRP (r=0.54, p=0.001). This study confirms the presence of an acute phase response as indicated by metabolic derangements and a moderate increase in C-reactive protein levels in sarcoidosis, particularly in those patients with constitutional symptoms. Future studies should focus on the clinical relevance and therapeutic implications of these findings.  (+info)

Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: discordant responses to IL-6. (7/655)

The rat serine protease inhibitor (Spi) 2 gene family includes both positive (Spi 2.2) and negative (Spi 2.1) acute phase reactants, facilitating modeling of regulation of hepatic acute phase response (APR). To examine the role of signal transducer and activation of transcription (STAT) proteins in the divergent regulation of these model genes after induction of APR, we evaluated the proximal promoters of the genes, focusing on STAT binding sites contained in these promoter elements. Induction of APR by turpentine injection includes activation of a STAT3 complex that can bind to a gamma-activated sequence (GAS) in the Spi 2.2 gene promoter, although the Spi 2.2 GAS site can bind STAT1 or STAT5 as well. To create an in vitro model of APR, primary hepatocytes were treated with combinations of cytokines and hormones to mimic the hormonal milieu of the whole animal after APR induction. Incubation of primary rat hepatocytes with interleukin (IL)-6, a critical APR cytokine, leads to activation of STAT3 and a 28-fold induction of a chloramphenicol acetyltransferase reporter construct containing the -319 to +85 region of the Spi 2.2 promoter. This suggests the turpentine-induced increase of Spi 2.2 is mediated primarily by IL-6. In contrast, although turpentine treatment reduces Spi 2.1 mRNA in vivo and IL-6 does not increase Spi 2.1 mRNA in primary rat hepatocytes, treatment of hepatocytes with IL-6 results in a 5. 4-fold induction of Spi 2.1 promoter activity mediated through the paired GAS elements in this promoter. Differential regulation of Spi 2.1 and 2.2 genes is due in part to differences in the promoters of these genes at the GAS sites. IL-6 alone fails to reproduce the pattern of rat Spi 2 gene expression that results from turpentine-induced inflammation.  (+info)

Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope. (8/655)

OBJECTIVE: To determine whether glutathione S-transferase GSTM1, GSTM3, GSTT1, and GSTP1 genotypes influence susceptibility or outcome in rheumatoid arthritis (RA). METHODS: 277 RA patients were compared with 577 controls to examine any associations between GST genotypes and susceptibility to RA. The effect of genotypes on outcome (Larsen and functional scores) and time integrated acute phase responses (erythrocyte sedimentation rate and C reactive protein) was assessed in 122 patients with disease duration of 5-10 years. GST and HLA-DRB1 genotypes were determined using polymerase chain reaction based assays. Data were analysed using multiple regression analysis with correction for age, sex, disease duration, and the DRB1 associated shared epitope (SE) and rheumatoid factor (RF) positivity where appropriate. RESULTS: The GSTM1*A/*B genotype was less common in RA cases (3 of 276) than in controls (22 of 591) (exact p = 0.047), though significance was lost when adjustment was made for multiple comparisons. The Larsen score was higher (p = 0.039) in the GSTM1 null patients (89.9) than those with other GSTM1 genotypes (74.7), and this was independent of the SE. Again, correction for multiple testing resulted in loss of significance. The difference in Larsen scores between patients homozygous or negative for the SE (87.9 v 74.3) was similar to that between GSTM1 null and non-null patients. No associations between GSTM3 or GSTT1 genotypes and disease markers were identified although the association between GSTP1*B/*B and Larsen score approached significance (p = 0.096). CONCLUSION: It is proposed that certain GSTs may influence susceptibility and radiological progression in RA and that this is independent of the effect of the HLA-DRB1 associated SE. The mechanism for this effect is presumed to be because of differences in the ability of various GST enzymes to utilise the cytotoxic products of oxidant stress. Although significance was lost after correction for multiple testing, the data indicate that further studies may be of value in RA to determine the influence of the GST and other genes involved in cellular protection against oxidative stress.  (+info)

Epidemiological studies link inhalation of particles to increased risk of cardiovascular disease. Inhaled particles may induce cardiovascular disease by several different mechanisms including translocation of particles to systemic circulation, activation of airway sensory nerves resulting in autonomic imbalance and particle-induced pulmonary inflammation and acute phase response. The acute phase response is the systemic response to acute and chronic inflammatory states caused by for example bacterial infection, virus infection, trauma and infarction. It is characterized by differential expression of ca. 50 different acute phase proteins including C-reactive protein and Serum amyloid A, which are the most differentially up-regulated acute phase response proteins. Blood levels of these two acute phase proteins are closely associated with risk of cardiovascular disease in epidemiological studies and SAA has been causally related to the formation of plaques in the aorta in animal studies. In a recent paper
Lipopolysaccharide (LPS) treatment of animals down-regulates the expression of hepatic genes involved in a broad variety of physiological processes, collectively known as the negative hepatic acute phase response (APR). Retinoid X receptor α (RXRα), the most highly expressed RXR isoform in liver, plays a central role in regulating bile acid, cholesterol, fatty acid, steroid and xenobiotic metabolism and homeostasis. Many of the genes regulated by RXRα are repressed during the negative hepatic APR, although the underlying mechanism is not known. We hypothesized that inflammation-induced alteration of the subcellular location of RXRα was a common mechanism underlying the negative hepatic APR. Nuclear RXRα protein levels were significantly reduced (~50%) within 1-2 hours after low-dose LPS treatment and remained so for at least 16 hours. RXRα was never detected in cytosolic extracts from saline-treated mice, yet was rapidly and profoundly detectable in the cytosol from 1 hour, to at least 4 hours,
Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ...
Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ...
The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effect of the acute phase response remains unknown. As the acute phase response is stimulated by diverse cytokines that activate either NF-κB or STAT3, we hypothesized that it could be eliminated by hepatocyte-specific interruption of both transcription factors. Here, we report that the elimination in mice of both NF-κB p65 (RelA) and STAT3, but neither alone, abrogated all acute phase responses measured. The failure to respond was consistent across multiple different infectious, inflammatory, and noxious stimuli, including pneumococcal pneumonia. When the effects of infection were analyzed in detail, pneumococcal pneumonia was found to alter the expression of over a thousand transcripts in the liver. This outcome was inhibited by the combined loss of RelA and STAT3. Moreover, this ...
Hjorth, J. , Jensen, N. R. , Lohse, C. , Notholt, J. , Skov, H. and Restelli, G. (1991): Gas phase reactions of interest in night time trophospheric chemistry , Proc EUROTRAC Symp 90 (P Borrell et al, eds ...
When a patient is exposed surgical stress, the endocrine system secretes hormones in response to that stress. These hormones further activate the immune system to release cytokines and other acute phase reactions. These processes are supposed to protect the body by upregulating the innate immune system and producing an inflammatory response that acts to protect and heal. However, uncontrolled surgical stress may cause a weaker immune response that may lead to delayed wound healing. The phenomenon of unplanned perioperative hypothermia is known to expose patients to additional surgical stress. The purpose of this preliminary experimental study was to determine the effect of a preoperative warming intervention on the acute phase response of surgical stress in surgical patients. Specifically, the aim of this study was to evaluate the effect of a prewarming intervention using a forced-air warming (FAW) device versus routine care (RC) using warmed cotton blankets on the development of unplanned hypothermia,
a) CRP: CRP is the commonest biomarker used in neonatal sepsis. It increases by around 6-18 hours of exposure, and peaks after 48 hours. CRP has a half-life of 18 hours and hence falls with the resolution of acute-phase reaction. CRP is highly specific, however, sensitivity is low6,7. Serial CRP monitoring increases its utility and can also be used in deciding the response as well as the duration of antimicrobial therapy. b) Procalcitonin: This is another acute-phase reactant which is produced by 2-4 hours of exposure, and peaks by 24-48 hours. The half-life is 25-30 hours. However, there is a physiologic rise of procalcitonin in newborns in the first 2 days of life, which makes it less helpful in EOS8. The sensitivity and specificity of procalcitonin is around 80%, with a particular use in LOS. Other acute phase reactant proteins such as a-1 antitrypsin, haptoglobin, lactoferrin, fibronectin are also being studied. ...
SI}} {{CMG}} ==Overview== Interleukins are a group of [[cytokine]]s (secreted signaling molecules) that were first seen to be expressed by [[white blood cell]]s ([[leukocyte]]s, hence the -leukin) as a means of communication (inter-). The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of bodily cells. The function of the [[immune system]] depends in a large part on interleukins, and [[rare disease,rare]] deficiencies of a number of them have been described, all featuring [[autoimmune disease]]s or [[immune deficiency]]. ==List== A list of interleukins: {, class=wikitable , Name ,, Source ,, Function ,- , [[Interleukin 1,IL-1]] ,, [[macrophage]]s ,, small amounts induce [[acute phase protein,acute phase reaction]], large amounts induce [[fever]]. ,- , [[Interleukin 2,IL-2]] ,, [[T helper cell,TH1-cells]] ,, stimulates growth and ...
Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages.
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Background: Lifespan extension is achieved through long-term application of dietary restriction (DR), and benefits of short-term dietary restriction on acute stress and inflammation have been observed. So far, the effects of short-term DR in humans are relatively unknown. We hypothesized that short-term DR in humans reduces the acute phase response following a well defined surgical trauma. Methods: Thirty live kidney donors were randomized between 30% preoperative dietary restriction followed by 1 d of fasting (n = 17) or a 4 d ad libitum regimen (n = 13) prior to surgery. Leukocyte subsets and numbers and serum cytokine levels were determined. Whole blood was stimulated with lipopolysaccharide (LPS) and cytokine production was determined. Results: A clear trend towards lower numbers of postoperative circulating leukocytes was observed in the DR group. IL-8 serum levels were significantly higher in the DR group over the first 6 postoperative d (P = 0.018). After LPS stimulation, significantly ...
Excess or ill-timed proteolytic events have, of necessity, to be restrained. Therefore, there are partner proteinase inhibitors to most of the known mammalian e...
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Lipopolysaccharide (LPS) Binding Protein (LBP) is a type 1 acute phase protein that is constitutively produced by the liver and rapidly upregulated during the acute phase response.
Tracks advances in the application of phase response (PR) analysis to the study of electrically excitable cells Focuses on applications of PR analysis in
CRP Antigen. C reactive protein (CRP), also known as PTX1, is encoded by a gene that belongs to the pentaxin family. This protein is involved in several host defense related functions. For instance, CRP has the ability to recognize foreign pathogens and damaged host cells and to initiate their elimination by interacting with the bloods humoral and cellular effector systems. Consequently, the level of this protein in plasma increases greatly during the acute phase response to tissue injury, infection, or other inflammatory stimuli.. [Provided by RefSeq, Sep 2009]. ...
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009] ...
Infection, whether acute, chronic, local, or systemic, is something that all surgeons respect and fear. To counter infection, tissue injury activates an acute-phase response mediated by the liver and promotes coagulation, immunity, and tissue regeneration. However, microorganisms are able to survive and disseminate throughout tissues because of virulence factors that they express. These virulence factors…
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Looking for online definition of acute phase reaction in the Medical Dictionary? acute phase reaction explanation free. What is acute phase reaction? Meaning of acute phase reaction medical term. What does acute phase reaction mean?
Acute-phase proteins (APPs) are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or decrease (negative acute-phase proteins) in response to inflammation. This response is called the acute-phase reaction (also called acute-phase response). The terms acute-phase protein and acute-phase reactant (APR) are often used synonymously, although some APRs are (strictly speaking) polypeptides rather than proteins. In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notable of which are the interleukins IL1, IL6 and IL8, and TNFα. The liver responds by producing a large number of acute-phase reactants. At the same time, the production of a number of other proteins is reduced; these proteins are, therefore, referred to as negative acute-phase reactants. Increased acute-phase proteins from the liver may also contribute to the promotion of sepsis. Positive acute-phase ...
Lipopolysaccharide (LPS) binding protein (LBP) is an acute phase protein with the ability to bind and transfer LPS of Gram-negative bacteria. This soluble pattern recognition molecule represents an important defense principle of the host. Regulation of the hepatic acute phase response and its termination are important mechanisms for limiting systemic inflammatory activity of the host. Here were analyze the cooperation of Interleukin (IL)-1, IL-6, and Dexamethasone (Dex) at LBP expression in the hepatoma cell lines HuH-7 and Hep G2. The major inducer of LBP expression is IL-6. Within the LBP promoter numerously highly consensus binding sites such as AP-1, C/EBP-beta? and STAT3 are present, that confer transcriptional activity as shown by truncation and mutation experiments. Additionally, activate NF-kappaB sites activated by IL-1 were detected at the LBP promoter. By mutation experiments of the promoter furthermore were found differentially active glucocorticoid response elements (GREs). The ...
The glomerular basement membrane (GBM) and extra-cellular matrix (ECM) are essential to maintain a functional interaction between the glomerular podocytes and the fenestrated endothelial cells in the formation of the slit diaphragm for the filtration of blood. Dysregulation of ECM homeostasis can cause Focal segmental glomerulosclerosis (FSGS). Despite this central role, alterations in ECM composition during FSGS have not been analyzed in detail yet. Here, we characterized the ECM proteome changes in miR-193a-overexpressing mice, which suffer from FSGS due to suppression of Wilms’ tumor 1 (WT1). By mass spectrometry we identified a massive activation of the acute phase response, especially the complement and fibrinogen pathways. Several protease inhibitors (ITIH1, SERPINA1, SERPINA3) were also strongly increased. Complementary analysis of RNA expression data from both miR-193a mice and human FSGS patients identified additional candidate genes also mainly involved in the acute phase response. In
An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS ...
Most tissue-damaging processes such as infections, inflammatory diseases and malignant neoplasms are associated with a major acute phase response of the C-reactive protein (CRP) and other acute reactants e.g. AAT, AAGP, C3C, C4 HAPT. The CRP response frequently precedes clinical symptoms, including fever. In normal healthy individuals CRP is a trace protein with a range up to 5 mg/L. After onset of an acute phase response the serum CRP concentration rises rapidly and extensively. Levels of up to thousand times the normal value are associated with severe stimuli such as myocardial infarction, major trauma, surgery or malignant neoplasm. CRP has a half-life of only a few hours, making it an ideal tool for clinical monitoring ...
Interleukin 1 (IL-1) plays an important role in host defense mechanisms by increasing body temperature, inducing the synthesis of a variety of lymphokines and hepatic acute phase proteins and acting as a chemoattractant for lymphocytes. However, in some microenvironments such as injured tissue or joint spaces, elevated IL-1 levels may contribute to pathologic processes, for example, proliferation and fibrosis of tissue involved in pannus formation as well as degradation of matrix and abnormal tissue architecture. To investigate potential mechanisms that may lead to excessive production of IL-1, we have examined the ability of IL-1 to participate in an amplification event by inducing its own gene expression leading to synthesis of biologically active IL-1. When injected into rabbits, recombinant human IL-1-alpha induced biphasic fevers, and during the second temperature elevation 3 hr later, a circulating pyrogenic material was detected by passive transfer of plasma to other rabbits. Induction of ...
Acute phase protein Acute-phase proteins are a class of proteins whose plasma concentrations increase (positive acute phase proteins) or decrease (negative
Turpentine in the Nose:. Use with caution and learn from my experience. I have used the turpentine in my sinus for sometime now. I slightly dilute it with water in the palm of my hand and standing up I snuff it into my sinus. It clears out any mucus and I believe it is even caring for the brain because evidently it penetrates the blood brain barrier; Therefore the biofilm melting property is quite health promoting.. Caution: I suspected Cytomegelo Virus (a herpes which can lead to Kaposis Sarcoma ( it is considered incurable due to the biofilm coating)) I am interested in mechanizing a cure.. While lying down on my side I chose to snuff a single drop of the diamond G turpentine into my nostril. If it had not been so painful, it would have been comical. The turpentine entered my sinus but also the sinus above my eye.. Instantly; The mucus drainage was profound! Sneezing violent. Entire area around my eye was bright red as well as the eye. The deep cleansing produced sinus pain and some swelling ...
BENESHT Trading Company started its commercial activity in 1392 regarding the purchase and sale of raw turpentine juice. The company is headquartered in Tehran and has offices in the western provinces of Iran to purchase the harvested crop. The company is the largest trading company currently with 300 employees in various sectors including purchasing, sales, accounting, warehousing, transportation … and having extensive relationships with more than 10,000 workers in the field of raw turpentine juice extraction. They are working and buying and exporting a huge amount of harvested raw turpentine juice (about 60%). From the very beginning of the activity, in order to eliminate intermediaries and access to the harvesters of the crop, he put extensive cooperation with the workers who harvested raw turpentine juice at the top of his agenda. For centuries, local workers have struggled to harvest. Prior to 1392, due to the lack of a reliable and well-known shopping center, these workers offered their ...
When an immune response occurs from challenge by a pathogen, a systemic acute phase or inflammatory response results that is considered to be the foundation of non-specific immunity. Antibody titers that arise as a result of the humoral response are not a direct burden on the animals pool of nutrients and are therefore nutritionally inconsequential. It is therefore the systemic acute phase response that has nutritional consequences for the animal. It is this response that is associated with a shift in nutrients use away from skeletal muscle accretion and towards hepatic secretion of acute phase proteins as well as cellular and macromolecule turnover (Klasing, 1998).. There is no question that a well-nourished bird is more immunologically competent and better able to cope with disease challenges than a poorly nourished bird. A change in feed intake leads to a change in nutrient and energy intake. The development and maturation of the immune system of young poultry fed nutritionally deficient ...
I cant yet leave the subject of the PRC, even if it is a bit technical. Not all researchers say that we have a long dead zone mid-day in regard to our response to bright light. The figure above shows the phase response of melatonin in the blood to light…
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.: Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients w
This work is focused on determining the rate controlling mechanisms of decarburisation of iron-carbon droplets with gas mixtures containing up to 10% oxygen at 1723 K. The results indicate that the decarburisation rate is limited by the transport of oxygen in the bulk gas to the melt surface. The work also shows the absence of any significant resistance to decarburisation from interfacial chemical kinetics or gas phase reactions. Phosphorus in the melt shows no influence on the rate of decarburisation. Chromium has no significant effect on the decarburisation rate ...
Background: Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response. Methods: A cross-sectional study was conducted to evaluate relationships between serum selenium ...
Increased levels of differentially regulated trout protein 1 (DRTP1) mRNA transcripts have been reported in fish after activation of the acute phase response. While the function of the DRTP1 protein still remains to be ...
Torturing turpentine, I thought that would be a fabulous name for a novel, likely autobiographical. I spend a great deal of time torturing turpentine which I must admit is a far better choice than actually drinking it. Dont drink the blue kool-aid, people. Its a term that comes from endless political debates, especially on the…
STAT3 antibody (signal transducer and activator of transcription 3 (acute-phase response factor)) for ICC/IF, IHC-P, WB. Anti-STAT3 pAb (GTX50709) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Objective: We aimed to determine the potential value of maternal serum levels of acute phase reactants in the prediction of preterm delivery in women with ...
Apr 29 20:00:33 ,Iowan, #startmeeting Apr 29 20:00:48 ,Iowan, Clocks are going off behind me - must be time to start Apr 29 20:00:51 ,Iowan, PRESENT Apr 29 20:01:09 * Chazz throws a present at Iowan Apr 29 20:01:19 * Iowan misses Apr 29 20:01:32 ,Chazz, D: Apr 29 20:01:52 * Chazz gently tosses a present at Iowan! :p Apr 29 20:02:22 * Iowan ducks after the first one missed Apr 29 20:02:42 ,Iowan, Anyone else? Apr 29 20:03:06 ,Infl8ableSoulm8, Im srta here. Apr 29 20:03:11 ,Infl8ableSoulm8, with an o Apr 29 20:04:28 ,Iowan, gringochapin joined a bit ago... or the machine did... Apr 29 20:05:45 ,Iowan, Off to the agenda, then. Apr 29 20:05:45 ,gringochapin, Im here. Just got distracted chatting in #hamradio Apr 29 20:06:26 ,Iowan, I should go there sometime - its been years since my xmitter was warm. Apr 29 20:07:07 ,Iowan, Meeting frequency... is weekly good, or should we back off a bit? Apr 29 20:07:27 ,Chazz, I vote we meet only when we actually have something to meet about. Apr 29 20:07:28 ...
void apr_random_init(apr_random_t *g, apr_pool_t *p, apr_crypto_hash_t *pool_hash, apr_crypto_hash_t *key_hash, apr_crypto_hash_t *prng_hash ...
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An article about application users and their perception.; Author: Bamaco2; Updated: 16 Apr 2004; Section: Programming Tips; Chapter: General Programming; Updated: 16 Apr 2004
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Looking for online definition of Acute phase reactant in the Medical Dictionary? Acute phase reactant explanation free. What is Acute phase reactant? Meaning of Acute phase reactant medical term. What does Acute phase reactant mean?
Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response. A cross-sectional study was conducted to evaluate relationships between serum selenium concentrations and CD4 count, plasma viral load, serum albumin, and acute phase response markers among 400 HIV-1-seropositive women. In univariate analyses, lower CD4 count, higher plasma viral load, lower albumin, and the presence of an acute phase response were each significantly associated with lower serum selenium concentrations. In multivariate analyses including all four of these covariates, only albumin remained significantly associated with serum selenium. For each 0.1 g/dl increase in serum albumin, serum selenium increased by 0.8 μg/l (p < 0.001). Women with an acute phase response also had lower serum selenium (by 5.6 μg/l, p = 0.06). Serum selenium was independently associated with serum
Results There were 42 female and 31 male patients with an age range of 18-54 years. In the comparison of laboratory parameters of the patients with or without the components of BDCAF, no significant relation could be found between headache, erythema nodosum, superficial thrombophlebitis, skin pustules, GIS and eye involvement and acute phase response parameters. However, we found significantly higher levels of ferritin in patients with arthritis and higher levels of fibrinogen in patients both with arthralgia and arthritis versus without joint involvement (p=0,01; p=0,030 and p=0,000; respectively). Also Hp levels in patients with genital ulceration and arthritis (p=0,005 and p=0,002) and Cp levels in patients with oral ulceration and arthritis were found to be higher compared to patients without these involvements (p=0,01 and p=0,001). Prealbumin as a negative acute phase reactant was determined as significantly lower in patients with joint involvement than the patients without it (p=0,023). ...
TY - JOUR. T1 - Characterization of ionic liquid‐based biocatalytic two‐phase reaction system for production of biodiesel. AU - Prabhavathi Devi, Bethala Lakshmi Anu. AU - Guo, Zheng. AU - Xu, Xuebing. PY - 2011. Y1 - 2011. N2 - The property of a variety of ionic liquids (ILs) as reaction media was evaluated for the production of biodiesel by enzymatic methanolysis of rapeseed oil. The IL Ammoeng 102, containing tetraaminum cation with C18 acyl and oligoethyleneglycol units, was found to be capable of forming oil/IL biphasic reaction system by mixing with substrates, which is highly effective for the production of biodiesel with more than 98% biodiesel yield and nearly 100% conversion of oil. Conductor‐like screening model for real solvent (COSMO‐RS) in silico prediction of substrate solubility and simulation of partition coefficient change vs. reaction evolution indicated that the amphiphilic property of Ammoeng 102 might be responsible for creating efficient interaction of immiscible ...
Kaori Maeda, Luke O. Schoeniger, Masahiko Shimada, Richard A. Winchurch, Timothy G. Buchman, James L. Robotham; Regulation of Acute Phase Gene Expression Following Surgery and Endotoxin Administration in the Anesthetized Pig. Anesthesiology 1993;79(6):1324-1337. Download citation file:. ...
1. It has been suggested that the physiological consequences of strenuous exercise are analogous to those of the acute-phase response.. 2. In 70 male and 20 female competitive distance runners, a marked, but transient, neutrophil leucocytosis occurred immediately after these athletes completed a standard (42 km) marathon race. Concomitant significant increases were noted in the plasma cortisol levels, creatine kinase activity, C-reactive protein level, total protein level and albumin level (P ,0.01).. 3. The plasma fibrinogen, C-reactive protein and total protein concentrations were markedly increased both 24 h and 48 h after exercise (P ,0.01). The serum haptoglobin level was significantly decreased after exercise (P ,0.01), and increased 48 h later (P ,0.05). There was no change in the serum iron level, total iron-binding capacity, per cent saturation of transferrin and serum ferritin level.. 4. A significant increase in interleukin-1-type activity was demonstrated immediately and 24 h after ...
L~..Lary IUeurotroph~cPactor: Pharmacokrnetics m-d Acute-Phase Response in Rat Falk Dittrich, Hans Thoenen, and Michael Sendtnet Ciliary neurotrophic factor (CNTF) supports the survival of motoneurons in vitro and in vivo. Recombinant CNTF is an investigational drug for the treatment of amyotrophic lateral sclerosis. We determined the pharmacokinetics of radioiodinated CNTF after intravenous injection into rats. CNTF shows a biphasic clearance with an initial plasma half-life of 2.9 minutes and is removed from the circulation by the liver. No accumulation of radioactivity was detectable in nerve tissue or skeletal muscle after intravenous injection of 0.1 pg and 0.5 pg of CNTF. Radioactive degradation products accumulate in the skin. Liver cells express specific binding proteins for CNTF, and the incorporation and degradation of intravenously injected CNTF by the liver may occur after association of CNTF with the soluble CNTF receptor cu in the circulation. Probably a9 a consequence of its ...
You may also wish to search for items by Bierbaum, V. and Bierbaum. 57 matching references were found. Bierbaum, V.M.; DePuy, C.H.; Shapiro, R.J., Gas phase reactions of anions with nitrous oxide and carbon dioxide, J. Am. Chem. Soc., 1977, 99, 5800. [all data] DePuy, C.H.; Bierbaum, V.M.; Schmitt, R.J.; Shapiro, R.H., Gas phase oxidation and reduction reactions with C6H7-, HNO-, and HO2-, J. Am. Chem. Soc., 1978, 100, 2970. [all data] Schmitt, R.J.; Bierbaum, V.M.; DePuy, C.H., Gas phase reactions of carbanions with triplet and singlet molecular oxygen, J. Am. Chem. Soc., 1979, 101, 6443. [all data] DePuy, C.H.; Bierbaum, V.M.; Flippin, L.A.; Brabowski, J.J.; King, G.K.; Schmidt, R.J.; Sullivan, S.A., Gas phase reactions of anions with substituted silanes, J. Am. Chem. Soc., 1980, 102, 5012. [all data] Bierbaum, V.M.; Schmidt, R.J.; DePuy, C.H.; Mead, R.H.; Schulz, P.A.; Lineberger, W.C., Reactions of carbanions with triplet and singlet molecular oxygen, J. Am. Chem. Soc., 1981, 103, 6262. [all ...
The serum protein 1-acid glycoprotein (AGP), also known as orosomucoid, is normally referred to as an archetypical positive acute phase protein. as analyzed by 2-D electrophoresis. This MAb was utilized to build up an immunoassay (ELISA) for quantification of AGP in pig serum samples. The adult serum concentrations of pig AGP had been in the number of 1C3 mg/ml in several regular pig breeds although it was low in G?ttingen and Ossabaw minipigs (in the 0.3 to 0.6 mg/ml vary) and higher in young (2C5 times old) regular pigs (mean: 6.6 mg/ml). Amazingly, pig AGP was discovered to Betanin work as a poor acute phase proteins during a selection of experimental infections and aseptic irritation with significant decreases in serum focus and in hepatic ORM1 expression through the acute stage response. To your understanding this is actually the first explanation in virtually any species of AGP being truly a negative severe phase protein. Launch Alpha-1-acid glycoprotein (AGP), also referred to as ...
Turpentine or Turpentine oil is a liquid derived from the distillation of pine tree species and has industrial and pharmaceutical uses. Their organic matter is
The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections. We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers ...
C-reactive protein is a serum acute-phase reactant that increases several thousand-fold in concentration during inflammation in most mammals. However, mouse C-reactive protein is considered to be a minor acute-phase reactant, since its blood level increases only from approx. 0.1 to 1-2 micrograms/ml. A mouse genomic clone of approximately 5 kb was obtained to determine the molecular basis for the regulation of the expression of mouse C-reactive protein. Several cis-acting elements in the 5′ flanking region that potentially regulate transcription were identified: two glucocorticoid-responsive elements, two CCAAT-enhancer-binding protein C (C/EBP) consensus elements that are required for the interleukin-1 responsiveness of some acute-phase reactant genes, an interleukin-6-responsive element, two hepatocyte nuclear factor-1 (HNF-1) elements and a single heat-shock element. Transfection of the hepatoma cell line Hep 3B.2 with a pCAT expression vector containing the 5′ flanking sequence from ...
IndianOils cross-country network of crude Oil and product pipelines is spread over 10,000 Km. The Corporation handles the largest network of petrol and diesel stations in the country.
The principal aim of this study was to improve the laboratory diagnosis of inflammation in farmed red deer, primarily through the investigation of blood cells and inflammatory proteins in a variety of inflammatory conditions. The objectives were: 1) To establish solidly based reference values for haematological parameters and certain acute phase proteins, including fibrinogen, that may be useful in detecting and assessing infection in red deer. 2) To investigate various factors that might affect the results for these parameters, such information being essential for correct interpretation of test results. 3) To investigate aspects of the acute phase response in red deer. 4) To investigate changes in the above parameters in deer in a selection of infections. 5) To explore the observed responses in terms of possible functions of the components by reference to the literature. Despite a lower content of myeloperoxidase in deer leucocytes, automated leucocyte differential equipment (Technicon H6000/C) ...
Diabetes mellitus is one of public health problem in world. Type 2 diabetes millitus (T2DM) which resistance cell to insulin. more inflammation occur in Patients with T2DM because of elevation of inflammatory marker like C3, C4 & hsCRP. This study was aimed to detect the level of acute phase reactant proteins (C3 , C4 and hsCRP) in T2DM patients. Blood samples were collected from 60 patients with T2DM and control group was included 30 healthy donors. C3, C4 & hsCRP levels were estimated for all samples. Samples were grouped according to complications of patients. The results showed that there was a significant increase in C3 level for patients with T2DM (199.0 mg/dl) compared to control group (135.4 mg /dl) while C4 level for T2DM (27.25 mg/dl) showed no significant change compared to control group( 30.04mg/dl). C3 level of patients under heart disease (199.6 mg/dl ), patients under thyroid disease (230.4 mg/dl) and patients without any disease (188.1 mg/dl) recorded significant elevation
CRP is an acute-phase plasma protein that increases during systemic inflammation. CRP is produced primarily in the liver and is regulated by proinflammatory cytokines, especially IL-6. In turn, we have shown here that CRP induces the release of IL-6 by PBMC and purified CD14+ monocytes, envisioning a feed-forward loop between CRP and IL-6. CRP levels in blood are normally very low and difficult to detect in healthy individuals, but increase rapidly with inflammation. Increased CRP concentrations have been reported in many diseases, including cardiovascular diseases, diabetes, inflammatory bowel diseases, arthritis, and many cancers. With respect to the CRP association with cancer (45), the robust association described between circulating levels of CRP and cancer risk suggest alternative possibilities: (i) elevated CRP might have a causal role in carcinogenesis, (ii) elevated CRP levels might be the result of an underlying cancer, and (iii) a third factor, such as chronic inflammation, might ...
Figure 1- The components of the innate immune system. Sentinel cells such as the macrophage detect potential environmental threats from infection, chemicals, and foods by PRRs that activate signaling pathways and release proinflammatory cytokines (IL-6 and TNF-α). Known PRRs include TLR-4, which senses bacterial LPS and the receptor for AGEs. Cytokines stimulate acute-phase protein production from the liver and also act on the brain to release adrenocorticotrophic hormone (and thereby cortisol from the adrenal gland) and activate the sympathetic nervous system with the release of catecholamines. Psychological stress can cause an acute-phase response via innervation of cytokine-producing cells and via activation of the sympathetic nervous system and adrenergic receptors on macrophages. Central cytokine-induced sickness behavior includes lethargy, sleep changes, and depression. The innate immune system also controls the adaptive (acquired) immune system via costimulatory molecule expression ...
Turpentine is an old folk remedy used for centuries to keep Candida in check. Learn which type of Turpentine is safe for human consumption, proper dosing, and an additional ingredient you must add to the Turpentine for it to be effective.
ABSTRACT C-reactive protein (CRP), an acute-phase plasma protein, is a major component of inflammatory reactions functioning as a… Expand ...
APRs add little information on top (and independent) of the combination of clinical variables included in the SDAI. A purely clinical score is a valid measure of disease activity and will have its greatest merits in clinical practice rather than research, where APRs are usually always available. The …
A.Groisman, C.Lobo, H.Cho, JK Campbell, YS Dufour, AM Stevens, A Levchenko, A microfluidic chemostat for experiments with bacterial and yeast cells, Nature Methods. 2005 Sep; 2(9):685-9. BK Cho, H Cho, H Yun, BG Kim, Simultaneous synthesis of enantiomerically pure (S)-amino acids and (R)-amines using /-aminotransferase coupling reactions with two-liquid phase reaction system, Journal of Molecular Catalysis B: Enzymatic, 2003 December 1; 26(3):273-85 BK Cho, H.Cho, SH Park, H Yun, BG Kim, Simultaneous synthesis of enantiomerically pure (S)-amino acids and (R)-amines using coupled transaminase reactions, Biotechnology and Bioengineering. 2003 Mar 30; 81(7):783-9 ...
Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma: DC Activation Occurs in the Airway Mucosa but Not in the Lung ...
Table 1 Heating of organic solvents by microwaves (50cm3, 560Watts for 1 minute). Superheating, which may result in boiling points being raised by up to 20oC above their conventional value under microwave irradiation (see Table 2 below), is widely believed to be responsible for the rate and yield increases which accompany many liquid phase reactions. Reports by a number of workers have suggested that other mechanisms peculiar to microwaves are responsible for some enhanced reactions, and these will be considered in other sections.. ...
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The proinflammatory cytokine Interleukin 1 beta (IL-1) is elevated in obese individuals and rodents which is implicated in impaired insulin secretion, decreased cell proliferation and apoptosis of pancreatic beta cells. amyloid A (SAA) which is an indication Cd247 of inflammation-induced acute phase response (*= 0.024). While there was no improvement of obesity, a significant improvement of glycemic control and of beta cell function is definitely achieved by this pharmacological treatment which may sluggish/prevent disease progression in Type 2 Diabetes. within the development of obesity, swelling, and insulin resistance inside a mouse model of diet-induced obesity, which appear to mimic human being disease more closely than genetic mouse models of obesity. To specifically address the part of IL-1 in obesity, we used an anti- mouse IL-1 monoclonal antibody (37) with shown activity (38). Earlier studies have used recombinant IL-1Ra which blocks the biological activity on IL-1 receptor of both ...
The NFκB pathway is complex and regulates many downstream effects depending on the type of stimulating ligand and cell context. [13] TLR9 can be activated by mycobaterial DNA. Further, intracellular viral ssRNA and dsRNA activate the inflammation that induces cleavage of the pro-form of IL-1β into its mature active form.95 In fact, mice lacking the TLR3, which recognizes dsRNA and activates cytokine synthesis, if infected with mouse-adapted influenzavirus have attenuated increases in NREM sleep, hypothermia, and body weight loss compared to the prototypical responses of normal mice infected with influenza.96 Further, intracellular dsRNA that is produced during viral replication is also recognized by cytoplasmic PAMPs.97 Thus, PAMPs play a crucial role in the recognition of pathogens that lead to the production of sleep regulatory cytokines and the acute phase response to infections. Potentially, mitochondria simply act as a physical scaffold that promotes inflammasome assembly. By continuing ...
Human C-reactive protein is an acute phase protein whose blood concentrations rise dramatically in response to inflammatory insults. Though CRP is primarily of...
The NF-κB family of transcription factors are conserved from flies to humans and regulate the expression of a wide variety of cellular and viral genes (reviewed in reference (1)). Biochemical and molecular characteristics of NF-κB and their activation pathways have been extensively studied, especially in terms of immune and acute phase responses. The mammalian NF-κB proteins, RelA (p65), c-Rel, RelB, p50/p105, and p52/p100, share the rel homology domain which facilitates dimerization, nuclear translocation and DNA binding. Transactivation domains are also present at the COOH termini of RelA, c-Rel, and RelB. These NF-κB proteins form multiple interchangeable heterodimers and homodimers and their activity is regulated by binding of IκB inhibitory factors which determine the localization of NF-κB dimers, either in the cytoplasm or in the nucleus. Upon activation, NF-κB dimers dissociate from IκB and translocate to the nucleus and then bind to the κB sites in promoters and enhancers of ...
Need more information about Report Methodology? Click here- https://www.factmr.com/connectus/sample?flag=RM&rep_id=4435. Country-specific assessment on demand for crude sulfate turpentine has been provided for each regional market, along with the market size valuation and forecast price point assessment, price index and impact analysis of key regional and country-wise dynamics, which were obtained through quotes from numerous crude sulfate turpentine manufacturers, experts, and suppliers. Y-o-Y growth projections have also been offered on all regional markets incorporated in the report. Moreover, future trends, growth prospects, and other possibilities related to the market have been answered in the report.. The report provides company-level market share analysis, which has been derived on the basis of the companys annual sales and segmental revenue in all the target end-use industries. The market has been forecasted based on constant currency rates. The report provides detailed competitive and ...
Definition : Immunoassay reagents intended to perform qualitative and/or quantitative analyses of body fluids (typically serum) to determine the protein alpha-1-acid glycoprotein (AAG), also known as orosomucoid. AAG is a plasma protein whose concentration rises significantly during acute inflammatory processes (i.e., it is an acute-phase reactant). Some causes of acute inflammatory responses include surgery, myocardial infarction, infections, and/or tumors. Increased levels of AAG typically occur within 12 hours of the injury and decrease in 4 or 5 days.. Entry Terms : Orosomucoid Determination Reagents , Alpha-1-Acid Glycoprotein (AAG) Determination Reagents , AAG (Alpha-1-Acid Glycoprotein) Determination Reagents , Reagents, Alpha-1-Acid Glycoprotein , Reagents, Immunoassay, Protein, Alpha-1-Acid Glycoprotein. UMDC code : 17256 ...
Turpentine is a perzine by Ilana. It is defined as a cut and paste zine that features music and zine reviews, band interviews, and other odds and ends. Issue five featured an interview with Dame Darcy. The seventh issue was published in 2005. ...
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Linear regression is then employed for no better reason than that users know how to type lm but not gam C Shalizi http://j.mp/hHYVIu (pdf) (h/t mja, 14 Apr ...
This Table of Contents lists column numbers, headings, time lines and names of Members in the Commons Hansard Debates text for ...
Leukemoid reaction Acute phase reaction Betty Ciesla (27 November 2018). "Chapter 10: Abnormalities of white blood cells: ...
Cytokines help stimulate the acute phase reaction in response to inflammation. Colchicine inhibits macrophage production of TNF ...
... effect on the acute phase reaction". Z Ernahrungswiss. 37 Suppl 1: 43-9. PMID 9558728. Schieven GL, Kallestad JC, Brown TJ, ... OSM can regulate the expression of acute phase proteins. OSM regulates the expression of various protease and protease ... "Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal ...
C-reactive protein (CRP) is an acute phase protein. Therefore, it is a better marker for acute phase reaction than ESR. While ... In some parts of the world the test continues to be referred to as Biernacki's Reaction (Polish: odczyn Biernackiego, OB). In ... ESR begins to rise at 24 to 48 hours after the onset of acute self-limited inflammation, decreases slowly as inflammation ... Diamond, Seymour; Nissan, George R. (2011-01-01), Waldman, Steven D. (ed.), "Chapter 27 - Acute Headache", Pain Management ( ...
He identified IL-6 as a hepatocyte stimulating factor which induces acute phase reactions. He prepared a monoclonal anti-IL-6 ... withdrawal phase III trial. Lancet 371(9617):998-1006, 2008 Kishimoto, T. Interleukin-6: From basic science to medicine, 40 ...
"Elevated fibrinogen in an acute phase reaction prolongs the reptilase time but typically not the thrombin time". Am. J. Clin. ...
A normal C-reactive protein can be used to exclude elevated ferritin caused by acute phase reactions.[citation needed] Ferritin ... Ong DS, Wang L, Zhu Y, Ho B, Ding JL (2005). "The response of ferritin to LPS and acute phase of Pseudomonas infection". ... Beck G, Ellis TW, Habicht GS, Schluter SF, Marchalonis JJ (January 2002). "Evolution of the acute phase response: iron release ... As ferritin is also an acute-phase reactant, it is often elevated in the course of disease. ...
... term effects of the TNFα antagonist infliximab on the acute phase reaction and activities of daily life in patients with ...
... acute phase reactions, and hematopoiesis. Researchers are interested in the potential of small-molecule inhibitors (such as the ...
Fever and an increased white blood cell count are features of the acute-phase reaction, while an increased heart rate is often ... The complications of SIRS include Acute kidney injury Shock Multiple organ dysfunction syndrome The causes of SIRS are broadly ... Patients with SIRS and acute organ dysfunction may be termed "severe SIRS". Note: ...
... the amount of StAR available to transfer cholesterol to the inner membrane limits how fast the reaction can go (the acute phase ... This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of ... This step is mediated primarily by the steroidogenic acute regulatory protein (StAR or STARD1). Upon stimulation of a cell to ... A study of the steroidogenic capacity of the adrenal cortex in infants with acute respiratory disease demonstrated that indeed ...
In the acute phase reaction, a further elevation is required to "limit" the damage caused by activated neutrophil granulocytes ... Kushner, Mackiewicz A (1993). The acute phase response: an overview. Acute-phase glycoproteins: molecular biology, biochemistry ... "Acute-phase protein α1-anti-trypsin: diverting injurious innate and adaptive immune responses from non-authentic threats". ... Acute-phase proteins, Enzymes used as drugs, Orphan drugs, Serine protease inhibitors). ...
... a resonant absorption effect used in magnetic resonance spectroscopy Acute phase reaction, a reaction due to the presence of ... guideline Accreditation in Public Relations Acute phase reactant, a class of proteins Adleman-Pomerance-Rumely primality test ...
Because one of the functions of elevated ferritin (an acute phase reaction protein) in acute infections is thought to be to ... Replacement of iron stores is seldom such an emergency situation that it cannot wait for any such acute infection to be treated ... Iron sucrose has an occurrence of allergic reactions of less than 1 in 1000. A common side effect is taste changes, especially ... "2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure". European Heart Journal. 37 (27): 2129- ...
Systemic inflammatory reaction results in stimulation of four major programs: the acute-phase reaction sickness behavior the ... They included studies of acute laboratory stressors (e.g. a speech task), short-term naturalistic stressors (e.g. medical ... Selye describes three stages of adaptation, including an initial brief alarm reaction, followed by a prolonged period of ... Like the stress response, the inflammatory reaction is crucial for survival. ...
Increase in phospholipase A2 activity is an acute-phase reaction that rises during inflammation, which is also seen to be ... May 2010). "Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice". The ... January 2011). "Secretory phospholipase AA2 pathway during pediatric acute respiratory distress syndrome: a preliminary study ... and has been shown to promote vascular inflammation correlating with coronary events in coronary artery disease and acute ...
... are elevated in these clinical states as part of the acute phase reaction. High platelet counts can occur in patients with ... In adults, acute infection, tissue damage, chronic inflammation and malignancy are the common causes of reactive ...
This response is called the acute-phase reaction (also called acute-phase response). The acute-phase reaction ... Acute-phase proteins (APPs) are a class of proteins whose concentrations in blood plasma either increase (positive acute-phase ... The terms acute-phase protein and acute-phase reactant (APR) are often used synonymously, although some APRs are (strictly ... acute-phase reactants. Increased acute-phase proteins from the liver may also contribute to the promotion of sepsis. TNF-α, IL- ...
This can occur for years until the inflammatory reaction rises again. In the inflammatory (acute) phase, the antigens from the ... Microfilariae are not normally present in this phase. A key feature of this phase is scar formation from affected tissue areas ... A polymerase chain reaction test can also be performed to detect a minute fraction, as little as 1 pg, of filarial DNA. Some ... The asymptomatic phase usually consists of high microfilaremia infection, and individuals show no symptoms of being infected. ...
... herpetic phase is characterized by when viral particles infiltrate the retina and vitreous causing an inflammatory reaction. ... ARN presentation in individuals can be characterized by two separate phases as listed below. The acute ... exposing a patient to antiviral agents in the earlier phases of the outbreak tend to decrease the duration of the active phase ... The late cicatricial phase of ARN includes changes in the way the vitreous is organized due to the cellular infiltration seen ...
They can be divided into three phases: Acute - mild inflammatory cell infiltration Subacute - intense inflammatory reactions ... However, since the etiopathogenesis is still not totally understood, the inflammatory reactions are only partly reacting to the ...
After the chemical mediators of the acute response subside, typically 2-24 hours after the original reaction, late-phase ... Prednisone may be prescribed to prevent a possible late phase Type I hypersensitivity reaction. Severe allergic reactions ( ... a hybrid of the above two types In the early stages of an acute IgE-mediated allergic reaction, lymphocytes previously ... or a skin reaction. Soy is among the eight most common foods inducing allergic reactions in children and adults. It has a ...
... and is identified by fluid and protein exudation along with a neutrophilic reaction. During the acute phase, the body attempts ... The inflammatory response occurs within two time periods: the acute phase, and the chronic phase. The acute phase occurs during ... The success of a biomaterial relies on the host tissue's reaction with the foreign material. Specific reactions between the ... Rn, Mitchell (2003). "Acute and chronic inflammation". Robbins Basic Pathology. Johnston, R. B. (1988-03-24). "Current concepts ...
... an acute response that occurs immediately after exposure to an allergen but may subside and a late-phase reaction prolonging ... After the chemical mediators of the acute response subside, late-phase responses can often occur because of the migration of ... In the early stages of acute allergic reaction, lymphocytes previously sensitized to a specific protein or protein fraction ... Sometimes prednisone will be prescribed to prevent a possible late-phase type I hypersensitivity reaction. Severe allergic ...
This phase can either subside or progress into a "late-phase reaction" which can substantially prolong the symptoms of a ... After the chemical mediators of the acute response subside, late-phase responses can often occur due to the migration of other ... The pathophysiology of allergic responses can be divided into two phases. The first is an acute response that occurs ... The reaction is usually seen 2-24 hours after the original reaction. Cytokines from mast cells may also play a role in the ...
This phase can either subside or progress into a "late-phase reaction" which can substantially prolong the symptoms of a ... After the chemical mediators of the acute response subside, late-phase responses can often occur due to the migration of other ... In the early stages of acute allergic reaction, lymphocytes previously sensitized to a specific protein or protein fraction ... Sometimes prednisone will be prescribed to prevent a possible late phase Type I hypersensitivity reaction. Severe allergic ...
... is associated with severe allergic reactions. In the phase 2b RADAR trial, 12 allergic-like reactions occurred shortly ... REG1 is being developed for use in patients undergoing percutaneous coronary intervention and the treatment of acute coronary ... "A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation ... a novel actively controlled factor IX inhibitor using RNA aptamer technology for treatment of acute coronary syndrome". Future ...
This phase can either subside or progress into a "late-phase reaction" which can substantially prolong the symptoms of a ... After the chemical mediators of the acute response subside, late-phase responses can often occur due to the migration of other ... The pathophysiology of allergic responses can be divided into two phases. The first is an acute response that occurs within ... In the early stages of acute allergic reaction, lymphocytes previously sensitized to a specific protein or protein fraction ...
This test utilises the acute phase proteins (C-Reactive Protein and Haptoglobin). In combination with basic clinical symptoms, ... Polymerase chain reaction (PCR) for antigen receptor rearrangements (PARR) identifies circulating tumour cells based on unique ... 2011 Jan;48(1):223-35 Utility of polymerase chain reaction for analysis of antigen receptor rearrangement in staging and ...
After the chemical mediators of the acute response subside, late-phase responses can often occur. This is due to the migration ... The reaction is usually seen 2-24 hours after the original reaction. Cytokines from mast cells may play a role in the ... Aside from these ambient allergens, allergic reactions can result from foods, insect stings, and reactions to medications like ... reaction characteristic of hives and angioedema. With insect stings, a large local reaction may occur in the form of an area of ...
IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow ... leading to depressive reactions.[89] This altered connectivity is mediated by IL-6 and its effect on epigenetic regulation of ... Pediatric acute appendicitis[edit]. interleukin-6 has been shown to be elevated in paediatric patients with acute appendicitis ... IL-6 is an important mediator of fever and of the acute phase response. ...
This meant that the FDA could "introduce important medicines to the market based on very promising phase 2 rather than phase 3 ... Due to the complexity, risk of adverse events and allergic reactions associated with biologics, management is very important ... acute events, or complex therapies, and provides comprehensive patient education services and coordination with the patient and ...
Inception is the first moment that the second phase (gas phase) appears in the system. This is the weakest cavitating flow ... Controlled cavitation can be used to enhance chemical reactions or propagate certain unexpected reactions because free radicals ... The Journal of Trauma and Acute Care Surgery. 87 (3): 690-698. doi:10.1097/TA.0000000000002290. PMID 30939579. S2CID 92996795. ... However, a decrease in static pressure could also help one pass the multi-phase diagram and initiate another phase change ...
They found that priming by either a beloved or a favorite hobby improved reaction times in identifying whether a string of ... "From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of ... Animal studies indicate that elevated activity of dopaminergic pathways can stimulate a cascade of reactions, including the ...
... into the vasoconstricting angiotensin II which causes a cascade of hormonal reactions which is part of the body's harmful phase ... Recombinant human ACE2 (rhACE2) is surmised to be a novel therapy for acute lung injury, and appeared to improve pulmonary ... While mACE2 does not appear to factor into the harmful phase of RAAS (the increase of blood pressure), its existence is vital ... Infused rhACE2 has been evaluated in clinical trials for the treatment of acute respiratory distress syndrome (ARDS).[65] ...
Early follicular phase (days 1-4). Mid follicular phase (days 5-9). Late follicular phase (days 10-14). Luteal phase (days 15- ... Estradiol is produced in the body from cholesterol through a series of reactions and intermediates.[10] The major pathway ... "Identification of a regulatory loop for the synthesis of neurosteroids: a steroidogenic acute regulatory protein-dependent ... and rise again during the luteal phase for a second peak. At the end of the luteal phase, estradiol levels drop to their ...
2006). "NXY-059 for acute ischemic stroke". N Engl J Med. 354 (6): 588-600. doi:10.1056/NEJMoa052980. PMID 16467546.. ... Duarte TL; Lunec J (2005). "Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of ... and four retinyl esters in serum determined simultaneously by reversed-phase HPLC with multiwavelength detection" (PDF). Clin ... reactions and products". Biological signals and receptors. 9 (3-4): 137-59. doi:10.1159/000014635. PMID 10899700.. ...
Free base cocaine separates as an oily layer, floating on the top of the now leftover aqueous phase. It is at this point that ... In crack users, acute respiratory symptoms have been reported, sometimes termed "crack lung". Symptoms include fever, coughing ... Loss of CO2 prevents the reaction from reversing back to cocaine hydrochloride. ... "Acute crack cocaine exposure induces genetic damage in multiple organs of rats". Environmental Science and Pollution Research ...
3). Under the right conditions of temperature and pressure, the reaction of solid UF. 4 with gaseous uranium hexafluoride (UF. ... Phase relationships in the uranium-oxygen system are complex. The most important oxidation states of uranium are uranium(IV) ... Acute cholinergic toxicity; Dose-dependent accumulation in cortex, midbrain, and vermis; Electrophysiological changes in ... Bromides and iodides of uranium are formed by direct reaction of, respectively, bromine and iodine with uranium or by adding UH ...
"Critical analysis of the efficacy of meditation therapies for acute and subacute phase treatment of depressive disorders: a ... Meditation experience was found to correlate negatively with reaction times on an Eriksen flanker task measuring responses to ... The group of meditators also had lower reaction times during this test than the group of non-meditators.[50] ... in orienting that represent the capacity to selectively attend to stimuli was calculated by examining changes in the reaction ...
A human Phase II clinical trial, with 41 patients, evaluated one synthetic lethal approach for tumors with or without MMR ... The first cancer genome was sequenced in 2008.[6] This study sequenced a typical acute myeloid leukaemia (AML) genome and its ... The characterization of mtDNA via real-time polymerase chain reaction assays shows the presence of quantitative alteration of ... This treatment is also being evaluated for breast cancer and numerous other cancers in Phase III clinical trials in 2016.[47] ...
However, the reaction of titanium dioxide and UVC is not a straight path. Several hundreds of reactions occur prior to the ... Difference frequency mixing (i.e., f1 + f2 − f3) as an advantage over sum frequency mixing because the phase matching can ... In humans, excessive exposure to UV radiation can result in acute and chronic harmful effects on the eye's dioptric system and ... Suspended nanoparticles in stained-glass prevent UV rays from causing chemical reactions that change image colors.[citation ...
"Acute stress reactions". In Gelder, Michael; Andreasen, Nancy; Lopez-Ibor, Juan; Geddes, John (eds.). New Oxford Textbook of ... the shock phase and the antishock phase.[71] *Shock phase: During this phase, the body can endure changes such as hypovolemia, ... a resistance phase, during which the organism makes efforts to cope with the threat; and an exhaustion phase, which occurs if ... The reaction of these systems causes a number of physical changes that have both short- and long-term effects on the body.[24] ...
"Acute Pancreatitis - Gastrointestinal Disorders". Merck Manuals Professional Edition. Merck.. [permanent dead link] ... the principal products of its reactions and their applications to the industrial arts]. Annales de chimie et de physique. 2nd ... "Blocking saccharide absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean ... A higher than normal concentration may reflect any of several medical conditions, including acute inflammation of the pancreas ...
A specific histochemical reaction, cyanide-resistant peroxidase, permits identification of leukemic blast cells with ... Acute eosinophilic leukemia (AEL) is a rare subtype of acute myeloid leukemia with 50 to 80 percent of eosinophilic cells in ... Patients with acute eosinophilic leukemia have a propensity for developing bronchospasm as well as symptoms of the acute ... "Acute Myeloid Leukemia (AML) Subtypes and Prognostic Factors". www.cancer.org. Retrieved 2022-02-03.. ...
the man simply chooses not to be a public figure, an attitude that resonates on a frequency so out of phase with that of the ... Such an approach generates dynamic tension and moments of acute self-consciousness, as both reader and author seem drawn ever ... the novel inspired mixed reactions from critics and reviewers. One reviewer remarked, "It is brilliant, but it is exhaustingly ...
... or create acute symptoms of hives.[185] These responses can be due to allergic reactions to aspirin, or more often due to its ... "Resolution phase lipid mediators of inflammation: agonists of resolution". Current Opinion in Pharmacology. 13 (4): 632-40. ... Reaction between acetic acid and salicylic acid can also form aspirin but this esterification reaction is reversible and the ... Aspirin overdose can be acute or chronic. In acute poisoning, a single large dose is taken; in chronic poisoning, higher than ...
More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, ... "Acute allergic interstitial nephritis after use of pantoprazole". CMAJ. 180 (5): 535-538. doi:10.1503/cmaj.080456. PMC 2645468 ... "Acid-suppressive medication use in acute stroke and hospital-acquired pneumonia". Annals of Neurology. 76 (5): 712-718. doi ...
... of people in the acute phase, but only 20-60% of those in the chronic phase.[6] Treatment of chronic disease is more effective ... Alternatively, T. cruzi DNA can be detected by polymerase chain reaction (PCR). In acute and congenital Chagas disease, PCR is ... In the acute phase of the disease, signs and symptoms are caused directly by the replication of T. cruzi and the immune system' ... T. cruzi shed acute-phase antigen (SAPA), which can be detected in blood using ELISA or Western blot,[22] has been used as an ...
Okamoto M, Kita T, Okuda H, Tanaka T, Nakashima T (July 1994). "Effects of aging on acute toxicity of nicotine in rats". ... After the initial stimulatory phase, a later period of depressor effects can occur and may include symptoms of hypotension and ... Alcohol flush reaction (AFR). Gastrointestinal diseases. *Alcoholic liver disease (ALD): *Alcoholic hepatitis ... Malizia E, Andreucci G, Alfani F, Smeriglio M, Nicholai P (April 1983). "Acute intoxication with nicotine alkaloids and ...
As of 2019[update], a bivalent (NoV GI.1/GII.4) intramuscular vaccine had completed phase 1 trials. In 2020 the phase 2b trials ... The norovirus was originally named the "Norwalk agent" after Norwalk, Ohio, in the United States, where an outbreak of acute ... Specific diagnosis of norovirus is routinely made by polymerase chain reaction (PCR) assays or quantitative PCR assays, which ... Norovirus causes about 18% of all cases of acute gastroenteritis worldwide. It is relatively common in developed countries and ...
The acute toxicity, carcinogenicity, and metabolism of sterigmatocystin has been compared with those for aflatoxin and several ... Németh Z, Molnár ÁP, Fejes B, Novák L, Karaffa L, Keller NP, Fekete E (November 2016). "Growth-Phase Sterigmatocystin Formation ... although a post column reaction with aluminium chloride has been used to increase sensitivity. More recently, methods using ...
... is one of the minerals that has been shown to catalyze an important biological reaction, the formose reaction, and may ... Acute scalenohedral crystals are sometimes referred to as "dogtooth spar" while the rhombohedral form is sometimes referred to ... Sharp, W. E.; Kennedy, G. C. (March 1965). "The System CaO-CO 2 -H 2 O in the Two-Phase Region Calcite + Aqueous Solution". The ... The overall reaction is CaCO3(s) + H2O + CO2(aq) → Ca2+(aq) + 2HCO−3(aq) If the amount of dissolved carbon dioxide drops, the ...
In South Asia during the 19th century, the Ahle Quran movement formed partially in reaction to the Ahle Hadith movement whom ... Influential Muslim lobbies in India have regularly insisted that the Hajj subsidy should be phased out as it is un-Islamic. ... While some scholars theorize that Muslim castes are not as acute in their discrimination as that among Hindus, Dr. Babasaheb ... the Islamic elements of architecture had already passed through different experimental phases in other countries like Egypt, ...
The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of ... Alkattan, A., & Alsalameen, E. (2021). Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical ... "Comparison of intravenous diltiazem and verapamil for the acute treatment of atrial fibrillation and atrial flutter". ...
The great migration phase of labor migrants in the 20th century began in Germany during the 1950s, as the sovereign Germany ... "Acute labour shortage in Lanka; 200,000 foreigners working here". The Sunday Times. 30 April 2017. Archived from the original ... In the United States, migrant farm workers experience work-related bone problems, respiratory problems and allergic reactions. ...
Another reaction to the yellow fever vaccine is known as yellow fever vaccine-associated acute neurotropic disease (YEL-AND). ... National Institute of Allergy and Infectious Diseases (NIAID) (1 June 2018), A Phase I Trial to Evaluate the Safety, ... This reaction, known as yellow fever vaccine-associated acute viscerotropic disease (YEL-AVD), causes a fairly severe disease ... The majority of adverse reactions to the 17D vaccine result from allergic reaction to the eggs in which the vaccine is grown. ...
Most people recover from the acute phase of the disease. However, some people - over half of a cohort of home-isolated young ... COVID-19 testing methods to detect the virus's nucleic acid include real-time reverse transcription polymerase chain reaction ( ... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel severe acute respiratory syndrome coronavirus. It was ... The virus can cause acute myocardial injury and chronic damage to the cardiovascular system. An acute cardiac injury was found ...
In the next phase 1809-16, Spain defeated all the uprising. A second round 1816-25 was successful and drove the Spanish out of ... Thompson says the Spanish revolt was, "a reaction against new institutions and ideas, a movement for loyalty to the old order: ... Economists concluded in early 2013 that, "Where once Spain's problems were acute, now they are chronic: entrenched unemployment ... "Major Phases in Roman History". Rome in the Mediterranean World. University of Toronto. Retrieved 2008-06-08. Great estates, ...
TPhP is only active as an additive flame retardant in its gas phase. Phase out of PBDEs may have increased the use of TPhP in ... Triphenyl phosphate exhibits low acute toxicity by dermal or oral contact. However, an increasing number of studies have linked ... Triphenyl phosphate is prepared by the SN2 reaction of phosphorus oxychloride and phenol.[citation needed] Triphenyl phosphate ... This reacts to form pyrophosphoric acid, which, when in its condensed phase, acts to block heat transfer. One of the most ...
Meloxicam as an Alternative to Alleviate Inflammatory and Acute-Phase Reactions in Beef Cattle Upon Lipopolysaccharide ... Meloxicam as an Alternative to Alleviate Inflammatory and Acute-Phase Reactions in Beef Cattle Upon Lipopolysaccharide ... Meloxicam as an Alternative to Alleviate Inflammatory and Acute-Phase Reactions in Beef Cattle Upon Lipopolysaccharide ... Meloxicam as an Alternative to Alleviate Inflammatory and Acute-Phase Reactions in Beef Cattle Upon Lipopolysaccharide ...
The acute phase reaction accompanies also intracerebral hemorrhage. Serum IL-6 and CRP level increases in the first days after ... Clinical significance of acute phase reaction in stroke patients. Front. Biosci. (Landmark Ed) 2008, 13(8), 2922-2927. https:// ... IL-6 induces synthesis of the acute phase proteins (APPs) in the liver. Higher blood IL-6 level in stroke patients is ... The level of C-reactive protein (CRP), the major APP in man, rises in blood during acute stroke reaching maximal values between ...
Acute Phase Reactions After Zoledronic Acid Infusion Might previous treatment with oral amino-bisphosphonates and higher 25(OH) ... D levels be protective factors for acute phase reaction to zoledronic acid infusion? ... Acute Pancreatitis in Patients With Severe Hypertriglyceridemia in a Multi-Ethnic Minority Population Find out more about the ... incidence and risk factors for hypertriglyceridemic acute pancreatitis in ethnic minority populations. ...
Significant number of adverse reactions for those on long-term steroids. In acute phase, few severe reactions present. ... Some can be used in acute life-threatening elevations, while others are used to help control calcium elevations after the acute ... PO maintenance therapy is available after acute event has resolved, but this therapy is experimental. With acute hypercalcemia ... Severe hypercalcemia in nonobstructive pyelonephritis with acute renal failure: hit or miss?. Am J Emerg Med. 2012 Oct. 30(8): ...
No acute-phase serum or tissue samples for viral isolation or polymerase chain reaction (PCR) were obtained. Convalescent-phase ... and acute hepatic and renal failure (Table). The next day, he had hypotension and respiratory failure requiring resuscitation, ...
Polymerase chain reaction amplification of Anaplasma phagocytophilum DNA from the patients acute-phase blood sample. Amplified ... Polymerase chain reaction amplification of Anaplasma phagocytophilum DNA from the patients acute-phase blood sample. Amplified ... in the acute-phase blood specimen (Figure) (12). No nucleic acids were amplified with primers specific for E. chaffeensis HE1 ... Thrombocytopenia-a common finding in the initial phase of tick-borne encephalitis. Infection. 1995;23:203-6. DOIPubMedGoogle ...
Leukemoid reaction Acute phase reaction Betty Ciesla (27 November 2018). "Chapter 10: Abnormalities of white blood cells: ...
Acute Phase Reaction Within three days after Zoledronic Acid Injection administration, an acute phase reaction has been ... Acute Phase Reaction. Within three days after Zoledronic Acid Injection administration, an acute phase reaction has been ... Injection Site Reactions Local reactions at the infusion site, such as redness or swelling, were observed infrequently. In most ... Hypersensitivity Reactions There have been rare reports of allergic reaction with intravenous zoledronic acid including ...
Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the ... Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the ... Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the ... Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the ...
Acute Phase Reaction Within three days after zoledronic acid injection administration, an acute phase reaction has been ... Acute Phase Reaction Within three days after zoledronic acid injection administration, an acute phase reaction has been ... Injection-Site Reactions Local reactions at the infusion-site, such as redness or swelling, were observed infrequently. In most ... Hypersensitivity Reactions There have been rare reports of allergic reaction with intravenous zoledronic acid including ...
Acute phase reaction (APR) is a systemic inflammation triggered by several conditions associated with lipid profile alterations ... Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction. Journal of Lipid Research ... Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at increased risk of developing late ... Oxidative stress promotes acute kidney injury (AKI). Higher HDL cholesterol concentrations are associated with less AKI. To ...
... reactions predominantly occur in patients treated during the acute phase of schistosomiasis ... Evidence suggests treatment with praziquantel in the acute phase of infection may not prevent progression from asymptomatic ... infection to acute schistosomiasis, or from asymptomatic infection/acute schistosomiasis into chronic phase; may lead to ... However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/ ...
Patients with severe traumatic brain injury (TBI) show a pronounced acute phase reaction. CSF IL-6 concentrations in patients ... Selected acute phase CSF factors in ischemic stroke: findings and prognostic value. BMC Neurol 2011;11:41.10.1186/1471-2377-11- ... Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries. Shock 1995;4 ... Beridze M, Shakarishvili R. Predicting value of cerebrospinal fluid proinflammatory factors in acute phase of ischemic stroke. ...
Acute Phase Reactions. Symptoms consistent with acute phase reactions have been reported with bisphosphonate use. Over the two ... These incidence rates are based on the reporting of any of 33 acute-phase reaction like symptoms within 3 days of the monthly ... b Combination of influenza-like illness and acute phase reaction. c Combination of rash pruritic, rash macular, rash papular, ... the overall incidence of acute phase reaction symptoms was 3% in the ibandronate sodium 2.5 mg daily group and 9% in the ...
... such as acute phase reaction, cytokine secretion and hyperactivation of hypothalamic-pituitary-adrenal axis.. It is speculated ... The evidence was also presented that lithium may alleviate the immune-endocrine component concomitant to an acute affective ...
... they are recognized by the neutrophils as foreign bodies and an acute-phase reaction is established. More neutrophils are ...
Therefore, here, next-generation sequencing (RNA-Seq) was performed on CL from the late luteal phase and compared with normally ... strongly contrasting with the acute luteolysis observed prepartum. The underlying biological mechanisms and the involvement of ... The acute phase response is an immediate reaction based on inflammation due to various elicitors such as tissue injury, ... The prepartum luteolysis was associated with immune inflammatory responses (p = 2.87e-14), including acute-phase reaction (p = ...
Acute-Phase Reaction 8% * Retinal Degeneration 8% * Polymerase Chain Reaction 7% * Injections 7% ...
Dendreon announced early completion of patient enrollment of its Phase 3 ProVent clinical trial. ... Acute Infusion Reactions: Acute infusion reactions (reported within 1 day of infusion) may occur and include nausea, vomiting, ... Adverse Reactions: The most common adverse reactions reported in clinical trials (≥ 15% of patients receiving PROVENGE) were ... Dendreon Completes Enrollment of Phase 3 ProVent Clinical Trial Evaluating Sipuleucel-T in Men on Active Surveillance - Target ...
Gånheim, Charina (2004). Studies on the acute phase reaction during respiratory infections in calves. Diss. (sammanfattning/ ... Grönlund Andersson, Ulrika (2004). The immune response during acute and chronic phase of bovine mastitis. Diss. (sammanfattning ...
CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase ...
In order to study the transition of memory T helper cells from the acute immune reaction to the memory phase and their ... The recruitment of approximately 20% of the cells generated in an immune reaction to the memory phase is remarkably similar to ... as to allow an unbiased analysis of the memory phase. In long-lasting immune reactions, e.g., those provoked by virus or ... of plasmablasts generated in acute immune reactions to the compartment of long-lived memory plasma cells (. Radbruch et al., ...
... though the liver parenchyma into the biliary ducts damages the liver and provokes reactions associated with the acute phase of ... In this chronic phase adult worms can survive several years in the absence of intervention [8, 9]. Despite its potent and broad ... This phase is accompanied by systemic disease including fever, nausea and abdominal pain. Once the adult is established in the ... An interesting example of alternate enzyme usage is shown for fumarate hydratase (reaction R01082), catalyzed by a class II ...
IL-6 affects B and T lymphocytes and has been shown to have a role in host defense, acute phase reactions, immune responses and ...
The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory ... Sepsis is one of the most common causes of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)(18). The ... 18 . Frutos-Vivar F, Nin N, Esteban A. Epidemiology of acute lung injury and acute respiratory distress syndrome. Curr Opin ... Acute in vivo effects of human recombinant tumor necrosis factor. Lab Invest 56 (6): 583-90, 1987. [PubMed] ...
As one source notes: "Sandra Fox and Donald Scherl speak of three phases of adjustment: acute reaction, outward adjustment and ... The counselor then went on to the second phase. "[T]he second phase is whats called the reorganization phase, and thats when ... its an acute stress reaction to the threat of being killed, and there are three phases of the syndrome." ... "These are acute stress reactions to different kinds of stressors but the most severe and the most long-lasting stress reactions ...
Polymerase chain reaction amplification of Anaplasma phagocytophilum DNA from the patients acute-phase blood sample. Amplified ...
  • Tumor necrosisfactor (TNF, cachexin or cachectin formerly known as tumor necrosisfactor-alpha or TNF-α) is a cytokine involved in systemic inflammation and isa member of a group of cytokines that stimulate the acute phase reaction. (creativebiomart.net)
  • However, vaccination can cause discomfort because of the systemic reaction and pain due to the local inflammation at the injection site. (biomedcentral.com)
  • Tumor Necrosis Factor is a cytokine (cell signaling protein) that plays a role in inflammation and is part of the acute phase reaction (concentrations of TNF will increase or decrease in response to inflammation). (innov-research.com)
  • Although low-grade inflammation is present before onset of clinical arthritis in large cohorts and can be detected using consecutive measurements, a single measurement of acute-phase reactants seems to have limited value for prediction of development of arthritis in individual patients. (jrheum.org)
  • In clinically active RA, inflammation is represented in the blood by elevated levels of acute-phase reactants such as high-sensitivity C-reactive protein (hsCRP), which can be used as a diagnostic marker for disease activity. (jrheum.org)
  • We agree that trauma-induced inflammation and acute-phase reaction are possible causes of the reported thromboelastograph findings in this patient. (silverchair.com)
  • Omega-3 acids modulate inflammatory reactions in the body and soothe the acute phase and stop inflammation. (strefamocy.pl)
  • Interleukin 6 (IL-6) is a pleiotropic a-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. (active-bioscience.de)
  • IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. (active-bioscience.de)
  • Interleukin 6 (IL-6) is an alpha-helical cytokine with a wide variety of biological functions, including inducement of acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. (bigdropinc.net)
  • Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. (elisachina.com)
  • Heat stroke is triggered by heat, but is driven by endotoxemia and the downstream effects of systemic inflammation, acute phase response and the pyrogenic response. (walshmedicalmedia.com)
  • In models of chronic inflammatory diseases, such as collagen-induced arthritis, murine colitis, or experimental autoimmune encephalomyelitis, IL-6 is proinflammatory [28, 29], whereas in models of acute inflammation IL-6 exhibits an anti-inflammatory profile [10]. (hostforstudent.com)
  • Many innate immune cells-neutrophils and monocytes/macrophages-produce and respond to IL-6, which can result in the amplification of inflammation and a switch from an acute to a chronic inflammatory state. (hostforstudent.com)
  • These biomarkers are for acute phase reactants, which means that whenever there is inflammation, these will increase. (eastcoastdaily.in)
  • Generally, acute inflammation is rapidly active and is short-term, it is followed by a systemic ( includes whole body system) reaction which is termed as the acute phase response, in which various plasma proteins alterations is involved. (microbiologynotes.org)
  • Generally, more than 1000 neutrophile is produced per day but it may increase tenfold during the process of the acute inflammation. (microbiologynotes.org)
  • When acute inflammation is mediated, neutrophils are attached or tethered to the endothelial walls of blood vessels with the help of the expression of E- selectin(enhanced by IL-1 or TNF), and P- selectin(enhanced by Histamine and Thrombin). (microbiologynotes.org)
  • Acute inflammation involves both systemic & localized responses. (microbiologynotes.org)
  • In the acute phase of periodontal disease, bacteria can initiate an infection and inflammation with significant swelling and bleeding and pain. (drdanenberg.com)
  • In the chronic phase of periodontal disease, inflammation exists for a long time or is constantly recurring. (drdanenberg.com)
  • In such users, allergic reactions in the form of rashes, inflammation of facial parts and/or oral organs, hives, itchiness, and extreme phases of dizziness or drowsiness may show up. (internationaldrugmart.com)
  • There are three basic phases of wound healing: inflammation, proliferation, and remodeling. (mhmedical.com)
  • IL-6 induces synthesis of the acute phase proteins (APPs) in the liver. (imrpress.com)
  • The IL-6-RE is well conserved in the cytokine-responsive regions of other acute-phase genes and serves as a binding site for nuclear proteins. (elsevier.com)
  • A different, hormone-inducible complex (complex II) was assembled specifically with nuclear proteins from acute-phase rat livers or from IL-6-treated human Hep 3B hepatoma cells. (elsevier.com)
  • Thus, the proteins building complex II likely participate in a general signal transduction mechanism mediating the transcriptional activation by IL-6 of several acute-phase genes. (elsevier.com)
  • Our study was conducted to test the hypothesis that acute-phase proteins can be used as markers to predict the development of RA in patients at increased risk. (jrheum.org)
  • Defects of two compositions shown in most EGFR-induced reactions, MST1 community of intracellular yeast megakaryocytes, and neurodegeneration of HOX proteins during mRNA are associated. (evakoch.com)
  • Overall, these reactions cause fever, leukocyte accumulation in the inflammatory position, muscle catabolism, and a change in the production of certain proteins by reducing albumin. (scirp.org)
  • By estimating circulating acute phase proteins in type 2 (T-2) diabetic patients, I tried to establish this hypothesis. (journalcra.com)
  • At 28d, serum acute phase proteins with immune function including complement C3, apolipoprotein A-I and A-II, alpha2-marcoglobulin, serotransferrin and liver carboxylesterase N were increased. (cdc.gov)
  • Proteins and cytokines produced during the acute phase will induce further leukocytosis. (epomedicine.com)
  • The tissue distention creates space for the influx of phagocytic cells and proteins that set the stage for later phases of healing. (mhmedical.com)
  • We report a patient with febrile illness and epidemiologic and clinical findings consistent with human granulocytic ehrlichiosis and tickborne encephalitis, in whom infection with Anaplasma phagocytophilum was demonstrated by polymerase chain reaction and seroconversion. (cdc.gov)
  • We report on a patient with TBE and HGE in whom infection with A. phagocytophilum was demonstrated by polymerase chain reaction (PCR) and seroconversion, and TBE virus infection was established by the presence of immunoglobin (Ig)M and IgG antibodies to TBE virus in serum. (cdc.gov)
  • Defective CD8 T cell memory following acute infection without CD4 T cell help. (cell.com)
  • These inflammatory responses are necessary to survive an infection, but may also result in host tissue injury (i.e. acute lung injury, hypotension or acute renal failure) ( 80 ). (antimicrobe.org)
  • 3 days during September or October, 2001, with confirmation of dengue infection by presence of antibodies in sera consistent with dengue infection or with presence of dengue viruses in acute-phase sera, detected by reverse transcriptase-polymerase chain reaction (RT-PCR). (cdc.gov)
  • The differential diagnoses for acute polyarthritis are wide and include infection-associated arthritis, reactive arthritis, Still's disease, systemic lupus erythematosus and rheumatoid arthritis. (science-fair-projects-online.com)
  • Antibodies to cardiolipin can occur acutely in a wide variety of conditions including infection,3 cancer,4 acute myocardial infarction5 and organ transplant,6 but these conditions were not reported to occur with polyarthritis. (science-fair-projects-online.com)
  • 5 Elevated levels of IL-6 in patients with community acquired pneumonia are associated with increased all-cause and cause-specific mortality during admission and over one-year post-admission, despite resolution of clinical signs of an acute infection. (secondopinionphysician.com)
  • DC-SIGN(+) cells are abundant in inflammatory skin with scabies infection or Th2-type dermatitis, suggesting that skin reactions to mosquito bites heighten the risk of infection and subsequent immunopathology. (cnrs.fr)
  • IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe infection and regulates the immune response, acute phase reaction and haematopoiesis. (abeomics.com)
  • Thus, the randomized double-blind Phase 2 clinical trial was run in Indonesia, where high SARS-CoV-2 infection rates have facilitated several COVID-19 vaccine clinical studies. (ctventures.com)
  • Acute myocarditis is an inflammatory process affecting the myocardium that mainly occurs secondary to a viral infection. (revespcardiol.org)
  • Gum disease (or periodontal disease) can be viewed as an acute infection as well as a chronic infection. (drdanenberg.com)
  • Detection of acute phase response and infection. (kuhlmann-biomed.de)
  • Antibodies elicited by natural infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or by vaccines against coronavirus disease 2019 (COVID-19) may sometimes exert a deleterious effect on the individual. (news-medical.net)
  • An acute or chronic localized infection which may or may not include symptoms of fever and muscle aches. (cdc.gov)
  • 12. Any evidence of acute illness or infection requiring systemic antibiotic therapy within past 3 days. (who.int)
  • Post-acute Sensory Neurological Sequelae in SARS-CoV2 Infection This study investigated the incidence and severity of peripheral neuropathy and pain symptoms in patients who tested positive for SARS-CoV-2 infection, both acutely and up to 90 days after testing. (medscape.com)
  • Someone in the earliest phase of HIV infection, called acute HIV infection , has a very high viral load and is much more likely to transmit HIV. (cdc.gov)
  • Pentraxin 3 (PTX3) belongs to the same superfamily of acute-phase reactants as CRP. (5dok.org)
  • These all parameters are well known acute phase reactants and very important tools for diagnosis for low grade chronic inflammatory reaction. (journalcra.com)
  • The biomarkers are used to reflect systemic acute-phase reaction (APR) which is in accordance with the severity of the tissue trauma. (jcritintensivecare.org)
  • 85% were mild (grade 1) and 15% moderate (grade 2) in severity with most adverse events characterized as local injection site reactions or systemic flu-like symptoms such as headache, arthralgias or myalgias. (ctventures.com)
  • In Phase 2 clinical studies, PH94B produced rapid onset anti-anxiety effects without requiring systemic uptake and distribution. (vistagen.com)
  • Although many arthropod attacks produce only mild, transient cutaneous changes, more severe local and systemic sequelae can occur, including potentially fatal toxic and anaphylactic reactions. (mhmedical.com)
  • SEAL BEACH, Calif.--( BUSINESS WIRE )--Dendreon Pharmaceuticals, a commercial-stage biopharmaceutical company and pioneer in the development of immunotherapy, announced early completion of patient enrollment of its Phase 3 ProVent clinical trial. (businesswire.com)
  • Steroids are usually effective and induce remission of the clinical symptoms, normalization of the acute-phase reaction, reduction in size of the retroperitoneal mass and also resolution of the obstructive complications. (radiopaedia.org)
  • The phase IV clinical study analyzes which people get Pfizer BioNTech Covid Vaccine and have Idiosyncratic drug reaction. (ehealthme.com)
  • Opdivo plus Yervoy -based combinations have shown significant improvements in OS in six Phase 3 clinical trials in five tumors to date: metastatic NSCLC, metastatic melanoma, advanced renal cell carcinoma, malignant pleural mesothelioma and esophageal squamous cell carcinoma. (biospace.com)
  • Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. (biomedcentral.com)
  • Here we provide a systematic review of frequency, risk factors, molecular and cellular mechanisms of reactions, clinical features, diagnostic work-up and therapy approaches to drug induced ED. (biomedcentral.com)
  • A clinical case is presented with a paraneoplastic syndrome type leukemoid reaction and malignant ascites by peritoneal spread, happening simultaneously with metachronous to major omentum metastases, as initial recurrence 7 years after a renal carcinoma. (scirp.org)
  • Clinical and epidemiologic information, as well as acute-phase serum specimens, were systematically collected from surveillance patients. (cdc.gov)
  • His research interests include clinical pathology of small animals, molecular and clinical aspects of the acute phase reaction, biomarkers, and metabolic aspects in the pathology of dairy cows. (esvcp-belgrade.rs)
  • Clinical symptoms and angiographic and MR imaging features were recorded before and after treatment, during both the acute and chronic phases, to look for inflammatory reaction. (bordeaux-neurocampus.fr)
  • IRVINE, Calif., Sept. 13, 2021 /PRNewswire/ - AIVITA Biomedical, Inc., a private biotechnology company specializing in innovative cell therapies, today announced results from its Phase 2 clinical study testing AIVITA's anti-SARS-CoV-2 Vaccine Enabling Kit, which allows any minimally-equipped facility to make personalized COVID-19 vaccines during the course of 2 patient visits one week apart. (ctventures.com)
  • A manuscript further detailing the results from this Phase 2 and AIVITA's prior Phase 1B clinical study for COVID-19 is being prepared for publication. (ctventures.com)
  • VistaGen is currently preparing for an exploratory Phase 2A clinical study of PH94B for acute treatment of adjustment disorder (AjD), an emotional or behavioral reaction considered excessive or out of proportion to a stressful event or significant life change, occurring within three months of the stressor, and/or significantly impairing a person's social, occupational and/or other important areas of functioning. (vistagen.com)
  • Clinical presentations include silent ischemia, angina pectoris, acute. (msdmanuals.com)
  • Takeda ( TSE:4502/NYSE:TAK ) today announced that ADVANCE-1, a randomized, placebo-controlled, double-blind Phase 3 clinical trial evaluating HYQVIA ® [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] for the maintenance treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), met its primary endpoint. (bharathanews.com)
  • Sickle cell disease (SCD) is a multisystem disorder associated with episodes of acute clinical events and progressive organ damage. (clinicaltrials.gov)
  • Prebreeding phase: Clinical and analytical laboratory findings. (cdc.gov)
  • Prebreeding phase: Clinical health findings. (cdc.gov)
  • To report SUSPECTED ADVERSE REACTIONS, contact Gland Pharma at 864-879-9994 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (nih.gov)
  • To report SUSPECTED ADVERSE REACTIONS, contact Ingenus Pharmaceuticals, LLC at 1-877-748-1970 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (nih.gov)
  • Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. (ehealthme.com)
  • Several factors have influenced the risk-benefit balance of the current immunization policy, including disease risk, risk for adverse vaccine reactions, and the cost of vaccines in the United States. (cdc.gov)
  • Cutaneous drug eruptions are one of the most common types of adverse reaction to medications, with an overall incidence of 2-3 % in hospitalized patients [ 1 ]. (biomedcentral.com)
  • For carbamazpine, several studies have found a common link between specific HLAs and different kinds of cutaneous adverse reactions, as for HLA-A*3101 in Japanese [ 30 ] and Europeans [ 31 ]. (biomedcentral.com)
  • Adverse reactions experienced following administration of INFeD may exacerbate cardiovascular complications in patients with preexisting cardiovascular disease. (globalrph.com)
  • 4 , 5 , 6 ] However, bisphosphonate therapy has been associated with adverse events such as acute-phase reaction, hypocalcemia, esophageal disease, atrial arrhythmia, osteonecrosis of the jaw, atypical femur fracture, and severe suppression of bone turnover. (e-jbm.org)
  • In the latter case, clearly specified quantitative benchmarks, such as median lethal doses (LD50s) for acute toxicity and no- observed-adverse-effect levels (NOAELs), or equivalent point of departure such as benchmark dose lower confidence limit (BMDL), for STOT-RE, are used. (cdc.gov)
  • however, vaccines have been associated with adverse reactions and even deaths in a few rare cases. (news-medical.net)
  • To this end, the current study reports its efficacy in preventing and treating adverse reactions caused by this mechanism. (news-medical.net)
  • Findings of these studies also showed that, unlike zoledronic acid, denosumab was not associated with renal toxicity and acute-phase reactions, and did not require dose adjustment in patients with renal impairment. (targetedonc.com)
  • 1973. Dose-response and ultrastructural alterations in dioxane carcinogenesis: Influence of methylcholanthrene on acute toxicity. (cdc.gov)
  • The objective of this study was to assess the sub-acute toxicity of HHT in Sprague-Dawley (SD) rats, and its effect on the activities of human microsomal cytochrome P450s (CYP450s) and UDP-glucuronosyltransferases (UGTs). (jkom.org)
  • We hypothesized that the split course may also lead to a significant reduction in the treatment volume for the second phase, so that late toxicity would be kept to a minimum. (medcraveonline.com)
  • Although many traditional radiologic contrast agents have been implicated in negative physiologic reactions, toxicity from procedural isotopic tracers is essentially nonexistent. (physsportsmed.com)
  • If no signs or symptoms of anaphylactic-type reactions follow the test dos e, administer the full therapeutic Dexferrum dose. (rxlist.com)
  • Taking an antimicrobial or removing the irritant causing the distress could relieve the acute symptoms and destroy some of the offending microbes. (drdanenberg.com)
  • These reactions can cause a wide variety of physical, mental and emotional symptoms, some acute (obvious, immediate) and some chronic canada goose uk harrods (hidden, delayed), and can aggravate or cause a number of diseases. (ujpestizenede.hu)
  • All of these emotions and physical symptoms are a natural reaction to losing someone we love. (theralphsiteshop.com)
  • No acute-phase serum or tissue samples for viral isolation or polymerase chain reaction (PCR) were obtained. (cdc.gov)
  • Polymerase chain reaction amplification of Anaplasma phagocytophilum DNA from the patient's acute-phase blood sample. (cdc.gov)
  • Use of polymerase chain amplification reaction for the detection of adenoviruses in ocular swab specimens. (bmj.com)
  • The organism in the acute phase of illness is best detected by polymerase chain reaction (PCR) and immunohistochemical methods (IHC) in skin biopsy specimens, and occasionally by PCR in appropriate whole blood specimens taken during the first week of illness, prior to antibiotic treatment. (cdc.gov)
  • To assess this, we retrospectively analyzed acute-phase serum samples from all dengue-negative patients by using real-time polymerase chain reaction (PCR) for Leptospira . (cdc.gov)
  • In addition, serum samples collected from a subset of patients during the first 5 days of illness were evaluated for dengue virus RNA by using reverse transcriptase-polymerase chain reaction (RT-PCR), as described previously ( 6 ). (cdc.gov)
  • Twenty equine blood and serum samples from the central West region of Brazil were evaluated by microscopic examination of buffy coat smear, enzyme-linked immunosorbent assay (ELISA), indirect fluorescent antibody test (IFAT) and nested polymerase chain reaction (nPCR). (scielo.br)
  • At admittance they underwent electrocardiography, echocardiography, blood analysis to determine myocardial injury markers, and polymerase chain reaction (PCR) testing for cardiotropic viruses in blood and respiratory secretions. (revespcardiol.org)
  • Expandingreal-time polymerase chain reaction testing capacity, through increased numbers of laboratories andoptimization of existing facilities, was clearly the main priority. (who.int)
  • Elevated CRP level in acute ischemic stroke predicts unfavorable outcome and is associated with increased risk of recurrent stroke or other cardiovascular events. (imrpress.com)
  • Functional alterations of innate lymphocytes, which can mount rapid immune responses and shape subsequent T cell reactions, were examined in the acute phase of ischemic stroke. (nih.gov)
  • Frequencies, intracellular perforin and interferon-gamma (IFN-gamma) expression of Vdelta2 T cells, CD3+ CD56+ natural killer T (NKT)-like and NK cells were examined in the peripheral blood of 20 healthy controls and 28 patients within 6 h of the onset of acute ischemic stroke and after 72 h by flow cytometry. (nih.gov)
  • Nelonemdaz in AIS With Endovascular Reperfusion This phase II trial of nelonemdaz, a novel multitarget neuroprotectant, showed promise in patients with acute ischemic stroke receiving endovascular reperfusion therapy. (medscape.com)
  • Hs-CRP appears within 1-2 days of acute myocardial infarction, peaks at 3 days, and becomes negative after 7 days. (medscape.com)
  • Hs-CRP correlates with peak creatine kinase-MB (CK-MB) following acute myocardial infarction. (medscape.com)
  • CRP may remain high for at least three months following acute myocardial infarction. (medscape.com)
  • Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure. (prescriptiondrugs.com)
  • Because coronary artery plaques that are not significantly stenotic (ie, do not result in ischemia during stress testing) may nonetheless rupture and cause an acute coronary syndrome, a normal stress test result does not guarantee future freedom from myocardial infarction. (msdmanuals.com)
  • Nine days after vaccination, he was hospitalized with a fulminant illness characterized by fever of 101.6º F (38.7º C) and acute hepatic and renal failure ( Table ). (cdc.gov)
  • IL-6 is a B-cell differentiation factor inducing antibody production, T-cell activation, the induction of hepatic acute phase protein synthesis, haematopoietic stimulation and tumour cell growth inhibition. (ijburns.com)
  • In this study, we have microinjected IL-1beta or lipopolysaccharide (LPS) into the rat brain as a simple model of brain injury and have systemically administered the TNF-alpha antagonist etanercept to discover whether hepatic TNF-alpha, produced as part of the acute-phase response to CNS injury, modulates the inflammatory response in the brain. (ox.ac.uk)
  • These findings suggest that TNF-alpha inhibitors may reduce CNS inflammatory responses by targeting the hepatic acute-phase response, and thus therapies for brain injury need not cross the blood-brain barrier to be effective. (ox.ac.uk)
  • IL-6 affects B and T lymphocytes and has been shown to have a role in host defense, acute phase reactions, immune responses and hematopoiesis. (prospecbio.com)
  • IL-6 plays a role in host defense, acute phase reactions, immune response, and hematopoiesis. (biolegend.com)
  • 6 This essential cytokine stimulates acute phase reactions, immune responses, hematopoiesis and various internal organs to prepare for host defense. (secondopinionphysician.com)
  • Interleukin 6 (IL-6) is a multifunctional cytokine that plays important roles in host defense, acute phase reactions, immune responses, nerve cell functions and hematopoiesis. (biossusa.com)
  • Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. (hostforstudent.com)
  • In that study, all 9 formulations were well-tolerated with no acute allergic reactions. (ctventures.com)
  • The level of C-reactive protein (CRP), the major APP in man, rises in blood during acute stroke reaching maximal values between 5 and 7 day after stroke onset. (imrpress.com)
  • CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. (fishersci.com)
  • CRP -- an acute phase serum protein - is a surrogate for the pro-inflammatory interleukin IL-6. (medscape.com)
  • All cases were associated with very high serum levels of the acute phase reaction protein serum amyloid A (SAA). (uni.lu)
  • Acute phase reaction and acute phase protein. (saripediatri.org)
  • To evaluate whether markers of the acute-phase response in patients presenting with arthralgia and positive anticitrullinated protein antibodies (ACPA) and/or immunoglobulin M rheumatoid factor (IgM-RF) could be predictive for the development of arthritis. (jrheum.org)
  • molecular protein appears possible reactions more mammalian. (evakoch.com)
  • This was followed by an acute phase response including CRP, SAA-1, SAP and haptoglobin as shown by elevated serum protein levels and liver gene expression. (cdc.gov)
  • Data from Europe are limited to the reports on coinfections with TBE virus and Borrelia burgdorferi sensu lato (s.l.) in patients with acute meningitis ( 3 - 7 ). (cdc.gov)
  • In patients with acute coronary disease, CRP level predicts mortality and cardiac complications. (medscape.com)
  • 4-7 IL-6 is involved in many physiological responses, including acute phase response, fever induction, angiogenesis, B and T cell differentiation as well as in lipid and iron metabolism. (secondopinionphysician.com)
  • 6 IL-6 is an important mediator of fever and the acute phase response that enhances the innate immune system to protect against tissue damage. (secondopinionphysician.com)
  • We collected acute-phase serum samples from febrile patients at 2 major hospitals in Dhaka, Bangladesh, during an outbreak of dengue fever in 2001. (cdc.gov)
  • As a high number of healthy patients having acute fever requiring hospitalization within a short period of time and in such confined areas is unusual, an outbreak investigation was conducted to reveal the etiology and associated risk factors of the illness. (who.int)
  • Here we show that in the memory phase of specific immune responses, most of the memory CD4 + T lymphocytes had relocated into the bone marrow (BM) within 3-8 weeks after their generation-a process involving integrin α2. (cell.com)
  • The prepartum luteolysis was associated with immune inflammatory responses ( p = 2.87e-14), including acute-phase reaction ( p = 4.10e-06). (biomedcentral.com)
  • A study was conducted to determine the effect of feeding yeast cell wall (YCW) products on the physiological and acute phase responses of crossbred, newly-received feedlot heifers to an endotoxin challenge. (ttu.edu)
  • These data indicate that YCW supplementation can decrease the physiological and acute phase responses of newly-received heifers following an endotoxin challenge. (ttu.edu)
  • It contributes to host defense through the stimulation of acute-phase responses, producing new blood cells, and immune reactions. (thyrocare.com)
  • Overt blood coagulation represents a threshold system with apparent all-or-none responses to various levels of stimuli, and an ensemble of opposing reactions determines the ultimate upregulation and downregulation of thrombin generation both locally and systemically. (mhmedical.com)
  • Treatment volume reductions between phase one and two were on average 56%, both completed the prescribed radiotherapy (RT) course, both had minimal acute reactions, and there was complete responses in all three primary sites at 6 weeks post RT. (medcraveonline.com)
  • Individuals with features of metabolic syndrome are particularly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus associated with the severe respiratory disease, coronavirus disease 2019 (COVID-19). (jlr.org)
  • The randomized, multicenter Phase 3 ProVent trial is assessing the efficacy of sipuleucel-T in reducing histopathologic disease progression in men on AS. (businesswire.com)
  • It should not be used during the acute phase of infectious kidney disease. (globalrph.com)
  • Many people with chronic lung disease periodically require a short-term burst of steroid pills or syrups to decrease the severity of acute attacks and prevent. (caixadopicoledabahia.com)
  • IgM tests are not strongly supported for use in serodiagnosis of acute disease, as the response may not be specific for the agent (resulting in false positives) and the IgM response may be persistent. (cdc.gov)
  • The test is indicated in individuals who have clinically significant dermatographism or extensive skin disease, those who cannot discontinue antihistamines or other medications with antihistamine actions (eg, tricyclic antidepressants), or those who have a history of anaphylactic reaction (because direct application of the suspected allergen may precipitate recurrent anaphylaxis). (medscape.com)
  • When the disease progresses to the chronic stage: strong bone solidification, abscesses, decayed bone fragments, wider periosteal reaction. (diagnosisbook.com)
  • Since then an enormous body of research, using ASIA as a paradigm, has begun to unravel the mystery of how environmental toxins, particularly the metal aluminum used in vaccines, can trigger an immune system chain reaction in susceptible individuals and may lead to overt autoimmune disease. (greenmedinfo.com)
  • Coenurosis can occur in both an acute and a chronic disease form. (farmhealthonline.com)
  • Acute coenurosis occurs during the migratory phase of the disease, usually about 10 days after the ingestion of large numbers of tapeworm eggs. (farmhealthonline.com)
  • Young lambs aged 6-8 weeks are most likely to show signs of acute disease. (farmhealthonline.com)
  • Acute disease is an important differential diagnosis for Cerebrocortical necrosis (CCN) . (farmhealthonline.com)
  • A Phase III Study to check the Safety and efficacy of the PCV 13 Vaccine in Healthy Infants in India in prevention of Pneumococcal disease caused by Streptococcus pneumonia. (who.int)
  • An Acute Phase Reaction can occur the first time a person is exposed to a new class of medication. (cvbonehealth.com)
  • These reactions might not occur in a specific order, and can occur together. (medlineplus.gov)
  • The side effects found and caused by bisphosphonates in patients, especially in children, have been described acute phase reactions that occur after the first intravenous administration of the drug and that resembles a flu, the most frequent are side effects related to the upper digestive system, such as gastric erosions and ulcers, among other effects observed in ( Table 1 ) [ 5 , 6 ]. (itmedicalteam.pl)
  • Notify physician or nursing staff immediately if these reactions occur. (mhmedical.com)
  • Zoledronic acid may be limited by the need for IV access and administration, the potential for first-dose acute-phase reactions, and the need to monitor renal function and adjust dosing in patients with renal impairment. (targetedonc.com)
  • Leukemoid Reaction and Malignant Ascites in a Renal Carcinoma with Sarcomatoid Differentiation. (scirp.org)
  • tion in renal tubules and the subsequent development of Acute Renal Failure. (medscape.com)
  • Revaccination with ppv should not be effective alone during the early active phase of tenderness posterior in epididymitis superioranterior in torsion of the renal brush border, conferred slightly greater fre-quency of resistance, and decreased agitation and aggression. (missouripodiatric.com)
  • Interleukin (IL)-1 is an endogenous pyrogen that induces several acute phase reactions. (ijburns.com)
  • OTCQX: RHHBY), today announced that the U.S. Food and Drug Administration (FDA) has granted full approval of Venclexta ® (venetoclax) in combination with azacitidine, or decitabine, or low-dose cytarabine (LDAC) for the treatment of newly diagnosed acute myeloid leukemia (AML) in adults 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy. (biospace.com)
  • Today's full approval is supported by the significant results that showed that Venclexta in combination with azacitidine extended overall survival for people with newly diagnosed acute myeloid leukemia who cannot tolerate intensive induction chemotherapy," said Levi Garraway, M.D., Ph.D., chief medical officer and head of Global Product Development. (biospace.com)
  • this is important, since reaction occurs at interfaces, and oxidant entrainment is a function of fragment size and relative velocity. (gre.ac.uk)
  • During the inflammatory phase, hemostasis occurs first. (mhmedical.com)
  • Among acute-phase sera, specimens from five patients, collected during the first 5 days of illness, were evaluated for dengue viruses by RT-PCR for serotype-specific dengue viral RNA ( 4 ). (cdc.gov)
  • Acute-phase serum specimens were assessed for dengue virus antibodies by using a commercial immunoglobulin (Ig)G and IgM capture enzyme-linked immunosorbent assay (ELISA) (PanBio Dengue Duo, PanBio Ltd., Brisbane, Queensland, Australia) ( 5 ). (cdc.gov)
  • www.ncbi.nlm.nih.gov/pubmed/16165563?dopt=AbstractPlus Effects of naloxone on acute respiratory distress syndrome (ARDS) in a randomized, placebo-controlled trial http://www.ncbi.nlm.nih.gov/pubmed/18331866 http://www.ncbi.nlm.nih.gov/pubmed/18713161 The study was stopped after 1 year, when all children achieved normal respiratory function. (btwchurch.com)
  • This triggers serious consequences, including the deadly acute respiratory distress syndrome (ARDS) and the well-known cytokine storm that indicates a dysregulated immune-inflammatory response. (news-medical.net)
  • Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. (biomedcentral.com)
  • hypersensitivity reactions. (empr.com)
  • The current single-center prospective study evaluated the association of Lp(a) levels with incident acute coronary syndrome to identify populations at risk of future events. (jlr.org)
  • ADVANCE-1 was a Phase 3, multicenter, placebo-controlled, double-blinded study to evaluate the efficacy, safety and tolerability of HYQVIA ® [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] as a maintenance therapy to prevent relapse in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). (bharathanews.com)
  • Serology can also be employed for detection, however an antibody response may not be detectable in initial samples, and paired acute and convalescent samples are essential for confirmation. (cdc.gov)
  • Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response. (ox.ac.uk)
  • Aim: Pathogenesis of type 2 diabetes is observed to be associated closely with acute phase response which is predominately cytokine-mediated. (journalcra.com)
  • The Phase 2 study showed that the personalized vaccine generates an enhanced immune memory response to SARS-CoV-2 in 96% of vaccinated subjects, in an environment dominated by the delta variant. (ctventures.com)
  • This paper reports our experiences in rapidly assessing Indonesia's COVID-19laboratory testing capacity in the early phase of the pandemic response. (who.int)
  • The 2nd, late-phase response, i.e. (lyceecharlesdegaulle.eu)
  • Reactions can vary by the person, the food, and the type of response. (ujpestizenede.hu)
  • Damage to the ciliary ganglion or short ciliary nerves (postganglionic parasympathetic nerve injury) produces an Adie tonic pupil, which is characterized by a large pupil with poor reaction to light but a strong and tonic pupillary response to near vision (light-near dissociation). (aao.org)
  • The absence of an endogenous luteolysin in absence of pregnancy results in long-lasting physiological pseudopregnancy, strongly contrasting with the acute luteolysis observed prepartum. (biomedcentral.com)
  • It appears that, even though they result in diminished steroidogenic output, the effect of antigestagens is more related to the withdrawal of P4 support than to the PGF2alpha-related inflammatory reaction observed at physiological parturition. (biomedcentral.com)
  • History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. (drugs.com)
  • Induction therapy for refractory acute lymphoblastic leukemia in children (in combination with other agents). (mhmedical.com)
  • The chronic form does not leave any sequelae, but the acute form can have sequelae in children or healthy adults. (diagnosisbook.com)
  • Assess levels of arousal, attention, and cognitive functioning using appropriate scales (See Appendix D ). Report decreased cognitive function that might indicate acute CNS depression. (mhmedical.com)
  • Etiology of acute conjunctivitis in children. (bmj.com)
  • The etiology of these reactions is not known. (globalrph.com)
  • The results suggest that rickettsial infections are more common than currently recognized as a cause of an acute febrile illness. (who.int)
  • From 5 to 11 May 2014 there were nine admitted cases of an undiagnosed acute febrile illness at one hospital in Munda, Western Province of Solomon Islands. (who.int)
  • There is a need to incorporate psychological services in the acute phase of illness for prompt recognition and management of psychiatric problems. (who.int)
  • Episodic pain, triggered by micro-vasoocclusion induced by sickled red blood cells, is the most common acute complication and the leading cause of hospitalization. (clinicaltrials.gov)
  • 114 out of 160 adult patients were assessed by telephone using validated scales (Stress Reactions and Adjustment Disorder Checklist, 9-item Patient Health Questionnaire, 7-item Generalized Anxiety Disorder Scale and Insomnia Severity Index) and a few open-ended questions about expectations and anticipated areas of need during hospitalization, including experiences with isolation. (who.int)
  • Might previous treatment with oral amino-bisphosphonates and higher 25(OH)D levels be protective factors for acute phase reaction to zoledronic acid infusion? (medscape.com)
  • PRINCETON, N.J.--( BUSINESS WIRE )-- Bristol-Myers Squibb (NYSE: BMY) today announced five-year results from Part 1 of the Phase 3 CheckMate -227 trial, which continues to demonstrate long-term, durable survival benefits of first-line treatment with Opdivo (nivolumab) plus Yervoy (ipilimumab) compared to chemotherapy in patients with metastatic non-small cell lung cancer (mNSCLC), regardless of PD-L1 expression levels. (biospace.com)
  • The potential for a delayed reaction must be considered when estimating the risk/benefit of treatment. (globalrph.com)
  • Have res us citation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during Dexferrum adminis tration. (rxlist.com)
  • We are making significant progress in preparing PH94B for launch of a pivotal Phase 3 study for acute treatment of anxiety in adults with social anxiety disorder in the second quarter of 2021. (vistagen.com)
  • NORTH CHICAGO, Ill., July 23, 2021 /PRNewswire/ - AbbVie (NYSE: ABBV) today announced that the U.S. Food and Drug Administration (FDA) approved DALVANCE® (dalbavancin) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) in pediatric patients from birth. (na-biz.com)
  • Definitive radiotherapy with Adaptive Split Course Radiotherapy (ASCRT), with RT given in two phases separated by weeks, could be done safely in select patients for whom a continuous course of treatment may have been too arduous on them and on family members responsible for providing transport. (medcraveonline.com)
  • Not only crystalline phases are formed but the residual glass is also changed in the aged GC 9 glass after the heat treatment. (ujpestizenede.hu)
  • Indomethacin Capsules is indicated for treatment of mild to moderate acute pain in adults. (drugs.com)
  • For treatment of mild to moderate acute pain, the dosage is 20 mg three times daily or 40 mg two or three times daily. (drugs.com)
  • Management strategies for SCD have evolved very slowly, and treatment of acute pain is still limited to supportive therapy with opioid medication. (clinicaltrials.gov)
  • Zavegepant Nasal Spray for the Acute Treatment of Migraine Zavegepant, a calcitonin gene related peptide receptor antagonist for intranasal administration, shows promise as an alternative to oral and parenteral agents for the acute treatment of migraine. (medscape.com)
  • Indeed, the combination of PK deficiency and sickle cell trait causing an acute sickling syndrome has been previously reported in two cases. (clinicaltrials.gov)
  • Interleukin 6 (IL-6) was established as a transcriptional inducer of the rat α 2 -macroglobulin gene, a prototype liver acute-phase gene. (elsevier.com)
  • Leukemoid reaction Acute phase reaction Betty Ciesla (27 November 2018). (wikipedia.org)
  • Acute- and convalescent-phase sera were tested for immunoglobulin (Ig) G and IgM dengue antibodies through capture enzyme-linked immunosorbent assay ( 5 , 6 ). (cdc.gov)
  • Oxidative stress promotes acute kidney injury (AKI). (jlr.org)
  • Acute Kidney Injury: Mounjaro has been buy flomax without a prescription reported with estrogens and progestins. (thisismyjoystick.com)
  • Psychological counseling may help a person who is unable to face the loss (absent grief reaction), or who has depression with grieving. (medlineplus.gov)
  • There is evidence that acute postoperative pain causes depression and depression lowers the threshold for pain. (biomedcentral.com)
  • Medications used in treating an acute manic episode and acute depression associated with bipolar disorder. (healthyplace.com)
  • In the integration phase, you may start to acknowledge your own feelings of anger, sadness, hurt, or depression. (sexinfoonline.com)
  • acute CNS depression. (mhmedical.com)
  • Sulfur has a long history of use as an antidote for acute exposure to radioactive material. (health-matrix.net)
  • Among those living with bronchitis or asthma, exposure to pollutants can lead to an acute spell of breathing problems. (internationaldrugmart.com)
  • Kobert (15) published one of the earlier tables of acute exposure limits. (cdc.gov)
  • 17. Fitch CP, Rapoza PA, Owens S. Epidemiology and diagnosis of acute conjunctivitis at an inner-city hospital. (bmj.com)
  • The Phase 3 study will be a randomized, double-blind, placebo-controlled, parallel comparison study conducted at approximately 15 sites in North America. (vistagen.com)
  • Neutrophils may predominate in reactions to fleas, mosquitoes, fire ants, and brown recluse spiders. (mhmedical.com)
  • These cells, specifically neutrophils and macrophages, are responsible for cleaning the wounded area of nonviable material so the proliferative phase can begin. (mhmedical.com)
  • Convalescent-phase serum samples collected 351 days after vaccination demonstrated a YF-neutralizing antibody titer of 1:640. (cdc.gov)
  • 55 acute-phase serum samples were additionally evaluated by using RT-PCR for dengue. (cdc.gov)
  • Anaphylactic-type reactions, including fatalities , have followed the parenteral administration of iron dextran injection. (rxlist.com)
  • Acute cerebral ischemia triggers interleukin-6 (IL-6) release into cerebrospinal fluid and blood. (imrpress.com)
  • This is followed by a slower clearance phase as ibandronate redistributes back into the blood from bone. (clustermed.info)
  • Cortisol is secreted into blood in reaction to acute stress, but also in phases of diminished feed intake and changed animal behavior. (biomedcentral.com)
  • Increases of cortisol in blood due to acute stress are reflected by steadily increasing levels in milk which in turn decrease as blood levels do. (biomedcentral.com)
  • In addition to HU, transfusions with normal red blood cells are widely used to treat severe sickle crises, but this strategy has limitations (not uniformly accessible, accompanied by risks of alloimmunization, hemolytic transfusion reactions and transfusional iron overload). (clinicaltrials.gov)
  • Three pathologic phases of the skeletal and soft-tissue manifestations of Infantile cortical hyperostosis have been described: early, subacute, and late. (medscape.com)
  • Large aneurysmal size and its proximity to surrounding brain tissue were predictive of this inflammatory reaction after flow diversion. (bordeaux-neurocampus.fr)
  • Most often, back pain is caused by either an acute injury or repeated stress on the vertebrae. (backpainreliefi.com)
  • The pain that is experienced in the acute phase is a normal bodily reaction to injury, and it can range in intensity from a stinging puncture to a tingling feeling. (backpainreliefi.com)
  • Fibroblasts are attracted to the wound by macrophages in the inflammatory phase and typically arrive in the area 48 to 72 hours after injury. (mhmedical.com)