An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.
Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
The concrete oleoresin obtained from Pinus palustris Mill. (Pinaceae) and other species of Pinus. It contains a volatile oil, to which its properties are due, and to which form it is generally used. (Dorland, 28th ed) Turpentine is used as a solvent and an experimental irritant in biomedical research. Turpentine toxicity is of medical interest.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70-kDa repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in MEMBRANE FUSION and SIGNAL TRANSDUCTION.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.
A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
The therapeutic use of mud in packs or baths taking advantage of the absorptive qualities of the mud. It has been used for rheumatism and skin problems.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
Methods of delivering drugs into a joint space.
Calculi occurring in a salivary gland. Most salivary gland calculi occur in the submandibular gland, but can also occur in the parotid gland and in the sublingual and minor salivary glands.
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
The privacy of information and its protection against unauthorized disclosure.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
A subcategory of protein tyrosine phosphatases that occur in the CYTOPLASM. Many of the proteins in this category play a role in intracellular signal transduction.
Venoms from animals of the phylum Arthropoda. Those most investigated are from scorpions and spiders of the class Arachnidae and from ant, bee, and wasp families of the Insecta order Hymenoptera. The venoms contain protein toxins, enzymes, and other bioactive substances and may be lethal to man.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Attachment of isoprenoids (TERPENES) to other compounds, especially PROTEINS and FLAVONOIDS.

Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist. (1/655)

The interleukin-1 (IL-1) receptor antagonist (IL-1ra) is an endogenous antagonist that blocks the effects of the proinflammatory cytokines IL-1alpha and IL-1beta by occupying the type I IL-1 receptor. Here we describe transgenic mice with astrocyte-directed overexpression of the human secreted IL-1ra (hsIL-1ra) under the control of the murine glial fibrillary acidic protein (GFAP) promoter. Two GFAP-hsIL-1ra strains have been generated and characterized further: GILRA2 and GILRA4. These strains show a brain-specific expression of the hsIL-1ra at the mRNA and protein levels. The hsIL-1ra protein was approximated to approximately 50 ng/brain in cytosolic fractions of whole brain homogenates, with no differences between male and female mice or between the two strains. Furthermore, the protein is secreted, inasmuch as the concentration of hsIL-1ra in the cerebrospinal fluid was 13 (GILRA2) to 28 (GILRA4) times higher in the transgenic mice than in the control animals. To characterize the transgenic phenotype, GILRA mice and nontransgenic controls were injected with recombinant human IL-1beta (central injection) or lipopolysaccharide (LPS, peripheral injection). The febrile response elicited by IL-1beta (50 ng/mouse icv) was abolished in hsIL-1ra-overexpressing animals, suggesting that the central IL-1 receptors were occupied by antagonist. The peripheral LPS injection (25 micrograms/kg ip) triggered a fever in overexpressing and control animals. Moreover, no differences were found in LPS-induced (100 and 1,000 micrograms/kg ip; 1 and 6 h after injection) IL-1beta and IL-6 serum levels between GILRA and wild-type mice. On the basis of these results, we suggest that binding of central IL-1 to central IL-1 receptors is not important in LPS-induced fever or LPS-induced IL-1beta and IL-6 plasma levels.  (+info)

Expression of serum amyloid A protein in the absence of the acute phase response does not reduce HDL cholesterol or apoA-I levels in human apoA-I transgenic mice. (2/655)

Plasma concentrations of high density lipoprotein (HDL) cholesterol and its major apolipoprotein (apo)A-I are significantly decreased in inflammatory states. Plasma levels of the serum amyloid A (SAA) protein increase markedly during the acute phase response and are elevated in many chronic inflammatory states. Because SAA is associated with HDL and has been shown to be capable of displacing apoA-I from HDL in vitro, it is believed that expression of SAA is the primary cause of the reduced HDL cholesterol and apoA-I in inflammatory states. In order to directly test this hypothesis, we constructed recombinant adenoviruses expressing the murine SAA and human SAA1 genes (the major acute phase SAA proteins in both species). These recombinant adenoviruses were injected intravenously into wild-type and human apoA-I transgenic mice and the effects of SAA expression on HDL cholesterol and apoA-I were compared with mice injected with a control adenovirus. Plasma levels of SAA were comparable to those seen in the acute phase response in mice and humans. However, despite high plasma levels of murine or human SAA, no significant changes in HDL cholesterol or apoA-I levels were observed. SAA was found associated with HDL but did not specifically alter the cholesterol or human apoA-I distribution among lipoproteins. In summary, high plasma levels of SAA in the absence of a generalized acute phase response did not result in reduction of HDL cholesterol or apoA-I in mice, suggesting that there are components of the acute phase response other than SAA expression that may directly influence HDL metabolism.  (+info)

C-reactive protein and outcome after ischemic stroke. (3/655)

BACKGROUND AND PURPOSE: Elevated concentrations of the acute-phase reactant C-reactive protein (CRP) predict ischemic cardiac events in both hospital- and population-based studies and may signify a role for inflammation in the destabilization of cardiovascular disease. We examined the relationship between CRP and outcome after acute ischemic stroke. METHODS: This was a subgroup analysis from a prospective observational study based in a University Hospital Acute Stroke Unit serving a population of approximately 260 000. Survival time and cause of death for up to 4 years after the index stroke were determined and related to CRP concentration within 72 hours of stroke and known prognostic variables by a Cox proportional hazards regression model. RESULTS: Ischemic stroke was diagnosed in 228 of 283 consecutive admissions. Median follow-up was 959 days. Geometric mean CRP concentration was 10.1 mg/L. Survival in those with CRP >10.1 mg/L was significantly worse than in those with CRP 10.1 mg/L and 63% of deaths in those with CRP +info)

Fish oil-enriched nutritional supplement attenuates progression of the acute-phase response in weight-losing patients with advanced pancreatic cancer. (4/655)

The presence of an acute-phase protein response (APPR) has been suggested to shorten survival and contribute to weight loss in patients with pancreatic cancer. Fatty acids derived from fish oil have been shown to alter proinflammatory cytokine production and acute-phase protein synthesis in vitro. The present study was designed to determine the effects of a fish oil-enriched nutritional supplement on the concentrations of a range of individual acute-phase proteins (APP) in patients with advanced pancreatic cancer. In a sequential series, 18 patients with pancreatic cancer received the supplement (providing 2 g eicosapentaenoic acid and 1 g docosahexaenoic acid/d) for 3 wk while another 18 received full supportive care alone. Six healthy subjects served as additional controls. Acute-phase proteins were measured before and after the 3-wk intervention period in cancer patients. At baseline, albumin, transferrin and pre-albumin were significantly reduced and fibrinogen, haptoglobin, alpha-1-acid glycoprotein, alpha-1-antitrypsin, ceruloplasmin and C-reactive protein (CRP) were significantly elevated in the cancer patients compared with healthy controls, reflecting their roles as negative and positive acute phase proteins, respectively. In the supplemented cancer group, the only significant change in APP concentrations over the 4-wk study period was an increase in transferrin. In the control cancer group there were further significant reductions in albumin, transferrin and pre-albumin, and a significant increase in CRP concentration. These results suggest that many positive and negative APP are altered in advanced pancreatic cancer. The APPR tends to progress in untreated patients but may be stabilized by the administration of a fish oil-enriched nutritional supplement. This may have implications for reducing wasting in such patients.  (+info)

SAA-only HDL formed during the acute phase response in apoA-I+/+ and apoA-I-/- mice. (5/655)

Serum amyloid A (SAA) is an acute phase protein of unknown function that is involved in systemic amyloidosis and may also be involved in atherogenesis. The precise role of SAA in these processes has not been established. SAA circulates in plasma bound to high density lipoprotein-3 (HDL3). The pathway for the production of SAA-containing HDL is not known. To test whether apolipoprotein (apo)A-I-HDL is required in the production of SAA-HDL, we analyzed the lipopolysaccharide (LPS)-induced changes in apoA-I+/+ and apoA-I-/- mice. In apoA-I+/+ mice, after injection of LPS, remodeling of HDL occurred: total cholesterol increased and apoA-I decreased slightly and shifted to lighter density. Dense (density of HDL3) but large (size of HDL2 ) SAA-containing particles were formed. Upon fast phase liquid chromatography fractionation of plasma, >90% of SAA eluted with HDL that was enriched in cholesterol and phospholipid and shifted "leftward" to larger particles. Non-denaturing immunoprecipitation with anti-mouse apoA-I precipitated all of the apoA-I but not all of the SAA, confirming the presence of SAA-HDL devoid of apoA-I. In the apoA-I-/- mice, which normally have very low plasma lipid levels, LPS injection resulted in significantly increased total and HDL cholesterol. Greater than 90% of the SAA was lipid associated and was found on dense but large, spherical HDL particles essentially devoid of other apolipoproteins.We conclude that serum amyloid A (SAA) is able to sequester lipid, forming dense but large HDL particles with or without apoA-I or other apolipoproteins. The capacity to isolate lipoprotein particles containing SAA as the predominant or only apolipoprotein provides an important system to further explore the biological function of SAA.  (+info)

Association of fatigue with an acute phase response in sarcoidosis. (6/655)

The pathophysiological explanation for fatigue, one of the most common symptoms in sarcoidosis, still has to be elucidated. It was hypothesized that the presence of fatigue is associated with an acute phase response in sarcoidosis. A cross-sectional study was performed in 38 sarcoidosis patients. Resting energy expenditure (REE) was measured in the fasting state by indirect calorimetry using a ventilated hood and adjusted for fat-free mass (FFM). Patients with fatigue (n=25) also suffered more frequently from other symptoms, such as exercise intolerance (p=0.01), the need for sleep (p=0.02) and weight loss (p=0.01), compared to those without fatigue (n=13). However, no relationship was found between fatigue and serum angiotensin-converting enzyme (sACE) or lung function impairment. Patients with fatigue had higher levels of C-reactive protein (CRP) (11.4+/-6.8 microg x mL(-1), p<0.0001) and REE adjusted for FFM (33.0+/-3.7 kcal x kg FFM(-1), p<0.003) compared to those without fatigue (3.2+/-2.2 mg x mL(-1); 29.2+/-2.8 kcal x kg FF(-1)). Furthermore, REE/FFM was significantly related to CRP (r=0.54, p=0.001). This study confirms the presence of an acute phase response as indicated by metabolic derangements and a moderate increase in C-reactive protein levels in sarcoidosis, particularly in those patients with constitutional symptoms. Future studies should focus on the clinical relevance and therapeutic implications of these findings.  (+info)

Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: discordant responses to IL-6. (7/655)

The rat serine protease inhibitor (Spi) 2 gene family includes both positive (Spi 2.2) and negative (Spi 2.1) acute phase reactants, facilitating modeling of regulation of hepatic acute phase response (APR). To examine the role of signal transducer and activation of transcription (STAT) proteins in the divergent regulation of these model genes after induction of APR, we evaluated the proximal promoters of the genes, focusing on STAT binding sites contained in these promoter elements. Induction of APR by turpentine injection includes activation of a STAT3 complex that can bind to a gamma-activated sequence (GAS) in the Spi 2.2 gene promoter, although the Spi 2.2 GAS site can bind STAT1 or STAT5 as well. To create an in vitro model of APR, primary hepatocytes were treated with combinations of cytokines and hormones to mimic the hormonal milieu of the whole animal after APR induction. Incubation of primary rat hepatocytes with interleukin (IL)-6, a critical APR cytokine, leads to activation of STAT3 and a 28-fold induction of a chloramphenicol acetyltransferase reporter construct containing the -319 to +85 region of the Spi 2.2 promoter. This suggests the turpentine-induced increase of Spi 2.2 is mediated primarily by IL-6. In contrast, although turpentine treatment reduces Spi 2.1 mRNA in vivo and IL-6 does not increase Spi 2.1 mRNA in primary rat hepatocytes, treatment of hepatocytes with IL-6 results in a 5. 4-fold induction of Spi 2.1 promoter activity mediated through the paired GAS elements in this promoter. Differential regulation of Spi 2.1 and 2.2 genes is due in part to differences in the promoters of these genes at the GAS sites. IL-6 alone fails to reproduce the pattern of rat Spi 2 gene expression that results from turpentine-induced inflammation.  (+info)

Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope. (8/655)

OBJECTIVE: To determine whether glutathione S-transferase GSTM1, GSTM3, GSTT1, and GSTP1 genotypes influence susceptibility or outcome in rheumatoid arthritis (RA). METHODS: 277 RA patients were compared with 577 controls to examine any associations between GST genotypes and susceptibility to RA. The effect of genotypes on outcome (Larsen and functional scores) and time integrated acute phase responses (erythrocyte sedimentation rate and C reactive protein) was assessed in 122 patients with disease duration of 5-10 years. GST and HLA-DRB1 genotypes were determined using polymerase chain reaction based assays. Data were analysed using multiple regression analysis with correction for age, sex, disease duration, and the DRB1 associated shared epitope (SE) and rheumatoid factor (RF) positivity where appropriate. RESULTS: The GSTM1*A/*B genotype was less common in RA cases (3 of 276) than in controls (22 of 591) (exact p = 0.047), though significance was lost when adjustment was made for multiple comparisons. The Larsen score was higher (p = 0.039) in the GSTM1 null patients (89.9) than those with other GSTM1 genotypes (74.7), and this was independent of the SE. Again, correction for multiple testing resulted in loss of significance. The difference in Larsen scores between patients homozygous or negative for the SE (87.9 v 74.3) was similar to that between GSTM1 null and non-null patients. No associations between GSTM3 or GSTT1 genotypes and disease markers were identified although the association between GSTP1*B/*B and Larsen score approached significance (p = 0.096). CONCLUSION: It is proposed that certain GSTs may influence susceptibility and radiological progression in RA and that this is independent of the effect of the HLA-DRB1 associated SE. The mechanism for this effect is presumed to be because of differences in the ability of various GST enzymes to utilise the cytotoxic products of oxidant stress. Although significance was lost after correction for multiple testing, the data indicate that further studies may be of value in RA to determine the influence of the GST and other genes involved in cellular protection against oxidative stress.  (+info)

Epidemiological studies link inhalation of particles to increased risk of cardiovascular disease. Inhaled particles may induce cardiovascular disease by several different mechanisms including translocation of particles to systemic circulation, activation of airway sensory nerves resulting in autonomic imbalance and particle-induced pulmonary inflammation and acute phase response. The acute phase response is the systemic response to acute and chronic inflammatory states caused by for example bacterial infection, virus infection, trauma and infarction. It is characterized by differential expression of ca. 50 different acute phase proteins including C-reactive protein and Serum amyloid A, which are the most differentially up-regulated acute phase response proteins. Blood levels of these two acute phase proteins are closely associated with risk of cardiovascular disease in epidemiological studies and SAA has been causally related to the formation of plaques in the aorta in animal studies. In a recent paper
Lipopolysaccharide (LPS) treatment of animals down-regulates the expression of hepatic genes involved in a broad variety of physiological processes, collectively known as the negative hepatic acute phase response (APR). Retinoid X receptor α (RXRα), the most highly expressed RXR isoform in liver, plays a central role in regulating bile acid, cholesterol, fatty acid, steroid and xenobiotic metabolism and homeostasis. Many of the genes regulated by RXRα are repressed during the negative hepatic APR, although the underlying mechanism is not known. We hypothesized that inflammation-induced alteration of the subcellular location of RXRα was a common mechanism underlying the negative hepatic APR. Nuclear RXRα protein levels were significantly reduced (~50%) within 1-2 hours after low-dose LPS treatment and remained so for at least 16 hours. RXRα was never detected in cytosolic extracts from saline-treated mice, yet was rapidly and profoundly detectable in the cytosol from 1 hour, to at least 4 hours,
Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ...
Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ...
The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effect of the acute phase response remains unknown. As the acute phase response is stimulated by diverse cytokines that activate either NF-κB or STAT3, we hypothesized that it could be eliminated by hepatocyte-specific interruption of both transcription factors. Here, we report that the elimination in mice of both NF-κB p65 (RelA) and STAT3, but neither alone, abrogated all acute phase responses measured. The failure to respond was consistent across multiple different infectious, inflammatory, and noxious stimuli, including pneumococcal pneumonia. When the effects of infection were analyzed in detail, pneumococcal pneumonia was found to alter the expression of over a thousand transcripts in the liver. This outcome was inhibited by the combined loss of RelA and STAT3. Moreover, this ...
Hjorth, J. , Jensen, N. R. , Lohse, C. , Notholt, J. , Skov, H. and Restelli, G. (1991): Gas phase reactions of interest in night time trophospheric chemistry , Proc EUROTRAC Symp 90 (P Borrell et al, eds ...
When a patient is exposed surgical stress, the endocrine system secretes hormones in response to that stress. These hormones further activate the immune system to release cytokines and other acute phase reactions. These processes are supposed to protect the body by upregulating the innate immune system and producing an inflammatory response that acts to protect and heal. However, uncontrolled surgical stress may cause a weaker immune response that may lead to delayed wound healing. The phenomenon of unplanned perioperative hypothermia is known to expose patients to additional surgical stress. The purpose of this preliminary experimental study was to determine the effect of a preoperative warming intervention on the acute phase response of surgical stress in surgical patients. Specifically, the aim of this study was to evaluate the effect of a prewarming intervention using a forced-air warming (FAW) device versus routine care (RC) using warmed cotton blankets on the development of unplanned hypothermia,
a) CRP: CRP is the commonest biomarker used in neonatal sepsis. It increases by around 6-18 hours of exposure, and peaks after 48 hours. CRP has a half-life of 18 hours and hence falls with the resolution of acute-phase reaction. CRP is highly specific, however, sensitivity is low6,7. Serial CRP monitoring increases its utility and can also be used in deciding the response as well as the duration of antimicrobial therapy. b) Procalcitonin: This is another acute-phase reactant which is produced by 2-4 hours of exposure, and peaks by 24-48 hours. The half-life is 25-30 hours. However, there is a physiologic rise of procalcitonin in newborns in the first 2 days of life, which makes it less helpful in EOS8. The sensitivity and specificity of procalcitonin is around 80%, with a particular use in LOS. Other acute phase reactant proteins such as a-1 antitrypsin, haptoglobin, lactoferrin, fibronectin are also being studied. ...
SI}} {{CMG}} ==Overview== Interleukins are a group of [[cytokine]]s (secreted signaling molecules) that were first seen to be expressed by [[white blood cell]]s ([[leukocyte]]s, hence the -leukin) as a means of communication (inter-). The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of bodily cells. The function of the [[immune system]] depends in a large part on interleukins, and [[rare disease,rare]] deficiencies of a number of them have been described, all featuring [[autoimmune disease]]s or [[immune deficiency]]. ==List== A list of interleukins: {, class=wikitable , Name ,, Source ,, Function ,- , [[Interleukin 1,IL-1]] ,, [[macrophage]]s ,, small amounts induce [[acute phase protein,acute phase reaction]], large amounts induce [[fever]]. ,- , [[Interleukin 2,IL-2]] ,, [[T helper cell,TH1-cells]] ,, stimulates growth and ...
Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages.
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Background: Lifespan extension is achieved through long-term application of dietary restriction (DR), and benefits of short-term dietary restriction on acute stress and inflammation have been observed. So far, the effects of short-term DR in humans are relatively unknown. We hypothesized that short-term DR in humans reduces the acute phase response following a well defined surgical trauma. Methods: Thirty live kidney donors were randomized between 30% preoperative dietary restriction followed by 1 d of fasting (n = 17) or a 4 d ad libitum regimen (n = 13) prior to surgery. Leukocyte subsets and numbers and serum cytokine levels were determined. Whole blood was stimulated with lipopolysaccharide (LPS) and cytokine production was determined. Results: A clear trend towards lower numbers of postoperative circulating leukocytes was observed in the DR group. IL-8 serum levels were significantly higher in the DR group over the first 6 postoperative d (P = 0.018). After LPS stimulation, significantly ...
Excess or ill-timed proteolytic events have, of necessity, to be restrained. Therefore, there are partner proteinase inhibitors to most of the known mammalian e...
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Lipopolysaccharide (LPS) Binding Protein (LBP) is a type 1 acute phase protein that is constitutively produced by the liver and rapidly upregulated during the acute phase response.
Tracks advances in the application of phase response (PR) analysis to the study of electrically excitable cells Focuses on applications of PR analysis in
CRP Antigen. C reactive protein (CRP), also known as PTX1, is encoded by a gene that belongs to the pentaxin family. This protein is involved in several host defense related functions. For instance, CRP has the ability to recognize foreign pathogens and damaged host cells and to initiate their elimination by interacting with the bloods humoral and cellular effector systems. Consequently, the level of this protein in plasma increases greatly during the acute phase response to tissue injury, infection, or other inflammatory stimuli.. [Provided by RefSeq, Sep 2009]. ...
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009] ...
Infection, whether acute, chronic, local, or systemic, is something that all surgeons respect and fear. To counter infection, tissue injury activates an acute-phase response mediated by the liver and promotes coagulation, immunity, and tissue regeneration. However, microorganisms are able to survive and disseminate throughout tissues because of virulence factors that they express. These virulence factors…
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Looking for online definition of acute phase reaction in the Medical Dictionary? acute phase reaction explanation free. What is acute phase reaction? Meaning of acute phase reaction medical term. What does acute phase reaction mean?
Acute-phase proteins (APPs) are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or decrease (negative acute-phase proteins) in response to inflammation. This response is called the acute-phase reaction (also called acute-phase response). The terms acute-phase protein and acute-phase reactant (APR) are often used synonymously, although some APRs are (strictly speaking) polypeptides rather than proteins. In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notable of which are the interleukins IL1, IL6 and IL8, and TNFα. The liver responds by producing a large number of acute-phase reactants. At the same time, the production of a number of other proteins is reduced; these proteins are, therefore, referred to as negative acute-phase reactants. Increased acute-phase proteins from the liver may also contribute to the promotion of sepsis. Positive acute-phase ...
Lipopolysaccharide (LPS) binding protein (LBP) is an acute phase protein with the ability to bind and transfer LPS of Gram-negative bacteria. This soluble pattern recognition molecule represents an important defense principle of the host. Regulation of the hepatic acute phase response and its termination are important mechanisms for limiting systemic inflammatory activity of the host. Here were analyze the cooperation of Interleukin (IL)-1, IL-6, and Dexamethasone (Dex) at LBP expression in the hepatoma cell lines HuH-7 and Hep G2. The major inducer of LBP expression is IL-6. Within the LBP promoter numerously highly consensus binding sites such as AP-1, C/EBP-beta? and STAT3 are present, that confer transcriptional activity as shown by truncation and mutation experiments. Additionally, activate NF-kappaB sites activated by IL-1 were detected at the LBP promoter. By mutation experiments of the promoter furthermore were found differentially active glucocorticoid response elements (GREs). The ...
The glomerular basement membrane (GBM) and extra-cellular matrix (ECM) are essential to maintain a functional interaction between the glomerular podocytes and the fenestrated endothelial cells in the formation of the slit diaphragm for the filtration of blood. Dysregulation of ECM homeostasis can cause Focal segmental glomerulosclerosis (FSGS). Despite this central role, alterations in ECM composition during FSGS have not been analyzed in detail yet. Here, we characterized the ECM proteome changes in miR-193a-overexpressing mice, which suffer from FSGS due to suppression of Wilms’ tumor 1 (WT1). By mass spectrometry we identified a massive activation of the acute phase response, especially the complement and fibrinogen pathways. Several protease inhibitors (ITIH1, SERPINA1, SERPINA3) were also strongly increased. Complementary analysis of RNA expression data from both miR-193a mice and human FSGS patients identified additional candidate genes also mainly involved in the acute phase response. In
An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS ...
Most tissue-damaging processes such as infections, inflammatory diseases and malignant neoplasms are associated with a major acute phase response of the C-reactive protein (CRP) and other acute reactants e.g. AAT, AAGP, C3C, C4 HAPT. The CRP response frequently precedes clinical symptoms, including fever. In normal healthy individuals CRP is a trace protein with a range up to 5 mg/L. After onset of an acute phase response the serum CRP concentration rises rapidly and extensively. Levels of up to thousand times the normal value are associated with severe stimuli such as myocardial infarction, major trauma, surgery or malignant neoplasm. CRP has a half-life of only a few hours, making it an ideal tool for clinical monitoring ...
Interleukin 1 (IL-1) plays an important role in host defense mechanisms by increasing body temperature, inducing the synthesis of a variety of lymphokines and hepatic acute phase proteins and acting as a chemoattractant for lymphocytes. However, in some microenvironments such as injured tissue or joint spaces, elevated IL-1 levels may contribute to pathologic processes, for example, proliferation and fibrosis of tissue involved in pannus formation as well as degradation of matrix and abnormal tissue architecture. To investigate potential mechanisms that may lead to excessive production of IL-1, we have examined the ability of IL-1 to participate in an amplification event by inducing its own gene expression leading to synthesis of biologically active IL-1. When injected into rabbits, recombinant human IL-1-alpha induced biphasic fevers, and during the second temperature elevation 3 hr later, a circulating pyrogenic material was detected by passive transfer of plasma to other rabbits. Induction of ...
Acute phase protein Acute-phase proteins are a class of proteins whose plasma concentrations increase (positive acute phase proteins) or decrease (negative
Turpentine in the Nose:. Use with caution and learn from my experience. I have used the turpentine in my sinus for sometime now. I slightly dilute it with water in the palm of my hand and standing up I snuff it into my sinus. It clears out any mucus and I believe it is even caring for the brain because evidently it penetrates the blood brain barrier; Therefore the biofilm melting property is quite health promoting.. Caution: I suspected Cytomegelo Virus (a herpes which can lead to Kaposis Sarcoma ( it is considered incurable due to the biofilm coating)) I am interested in mechanizing a cure.. While lying down on my side I chose to snuff a single drop of the diamond G turpentine into my nostril. If it had not been so painful, it would have been comical. The turpentine entered my sinus but also the sinus above my eye.. Instantly; The mucus drainage was profound! Sneezing violent. Entire area around my eye was bright red as well as the eye. The deep cleansing produced sinus pain and some swelling ...
BENESHT Trading Company started its commercial activity in 1392 regarding the purchase and sale of raw turpentine juice. The company is headquartered in Tehran and has offices in the western provinces of Iran to purchase the harvested crop. The company is the largest trading company currently with 300 employees in various sectors including purchasing, sales, accounting, warehousing, transportation … and having extensive relationships with more than 10,000 workers in the field of raw turpentine juice extraction. They are working and buying and exporting a huge amount of harvested raw turpentine juice (about 60%). From the very beginning of the activity, in order to eliminate intermediaries and access to the harvesters of the crop, he put extensive cooperation with the workers who harvested raw turpentine juice at the top of his agenda. For centuries, local workers have struggled to harvest. Prior to 1392, due to the lack of a reliable and well-known shopping center, these workers offered their ...
When an immune response occurs from challenge by a pathogen, a systemic acute phase or inflammatory response results that is considered to be the foundation of non-specific immunity. Antibody titers that arise as a result of the humoral response are not a direct burden on the animals pool of nutrients and are therefore nutritionally inconsequential. It is therefore the systemic acute phase response that has nutritional consequences for the animal. It is this response that is associated with a shift in nutrients use away from skeletal muscle accretion and towards hepatic secretion of acute phase proteins as well as cellular and macromolecule turnover (Klasing, 1998).. There is no question that a well-nourished bird is more immunologically competent and better able to cope with disease challenges than a poorly nourished bird. A change in feed intake leads to a change in nutrient and energy intake. The development and maturation of the immune system of young poultry fed nutritionally deficient ...
I cant yet leave the subject of the PRC, even if it is a bit technical. Not all researchers say that we have a long dead zone mid-day in regard to our response to bright light. The figure above shows the phase response of melatonin in the blood to light…
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.: Interleukin 1 receptor antagonist (IL-1Ra) levels are elevated in the blood of patients w
This work is focused on determining the rate controlling mechanisms of decarburisation of iron-carbon droplets with gas mixtures containing up to 10% oxygen at 1723 K. The results indicate that the decarburisation rate is limited by the transport of oxygen in the bulk gas to the melt surface. The work also shows the absence of any significant resistance to decarburisation from interfacial chemical kinetics or gas phase reactions. Phosphorus in the melt shows no influence on the rate of decarburisation. Chromium has no significant effect on the decarburisation rate ...
Background: Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response. Methods: A cross-sectional study was conducted to evaluate relationships between serum selenium ...
Increased levels of differentially regulated trout protein 1 (DRTP1) mRNA transcripts have been reported in fish after activation of the acute phase response. While the function of the DRTP1 protein still remains to be ...
Torturing turpentine, I thought that would be a fabulous name for a novel, likely autobiographical. I spend a great deal of time torturing turpentine which I must admit is a far better choice than actually drinking it. Dont drink the blue kool-aid, people. Its a term that comes from endless political debates, especially on the…
STAT3 antibody (signal transducer and activator of transcription 3 (acute-phase response factor)) for ICC/IF, IHC-P, WB. Anti-STAT3 pAb (GTX50709) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Objective: We aimed to determine the potential value of maternal serum levels of acute phase reactants in the prediction of preterm delivery in women with ...
Apr 29 20:00:33 ,Iowan, #startmeeting Apr 29 20:00:48 ,Iowan, Clocks are going off behind me - must be time to start Apr 29 20:00:51 ,Iowan, PRESENT Apr 29 20:01:09 * Chazz throws a present at Iowan Apr 29 20:01:19 * Iowan misses Apr 29 20:01:32 ,Chazz, D: Apr 29 20:01:52 * Chazz gently tosses a present at Iowan! :p Apr 29 20:02:22 * Iowan ducks after the first one missed Apr 29 20:02:42 ,Iowan, Anyone else? Apr 29 20:03:06 ,Infl8ableSoulm8, Im srta here. Apr 29 20:03:11 ,Infl8ableSoulm8, with an o Apr 29 20:04:28 ,Iowan, gringochapin joined a bit ago... or the machine did... Apr 29 20:05:45 ,Iowan, Off to the agenda, then. Apr 29 20:05:45 ,gringochapin, Im here. Just got distracted chatting in #hamradio Apr 29 20:06:26 ,Iowan, I should go there sometime - its been years since my xmitter was warm. Apr 29 20:07:07 ,Iowan, Meeting frequency... is weekly good, or should we back off a bit? Apr 29 20:07:27 ,Chazz, I vote we meet only when we actually have something to meet about. Apr 29 20:07:28 ...
void apr_random_init(apr_random_t *g, apr_pool_t *p, apr_crypto_hash_t *pool_hash, apr_crypto_hash_t *key_hash, apr_crypto_hash_t *prng_hash ...
All of the pre-match build up, live text commentary, audio commentary, match stats and highlights for Cheltenham Town vs Leyton Orient on 10 Apr 21
An article about application users and their perception.; Author: Bamaco2; Updated: 16 Apr 2004; Section: Programming Tips; Chapter: General Programming; Updated: 16 Apr 2004
Thanks girls, today is a much happier, lighter day, Im so relieved even though he has more ahead, right now he is cancer free. He was like a different man last night!! Frankie is happy today too!! 70885 - page 59
Looking for online definition of Acute phase reactant in the Medical Dictionary? Acute phase reactant explanation free. What is Acute phase reactant? Meaning of Acute phase reactant medical term. What does Acute phase reactant mean?
Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response. A cross-sectional study was conducted to evaluate relationships between serum selenium concentrations and CD4 count, plasma viral load, serum albumin, and acute phase response markers among 400 HIV-1-seropositive women. In univariate analyses, lower CD4 count, higher plasma viral load, lower albumin, and the presence of an acute phase response were each significantly associated with lower serum selenium concentrations. In multivariate analyses including all four of these covariates, only albumin remained significantly associated with serum selenium. For each 0.1 g/dl increase in serum albumin, serum selenium increased by 0.8 μg/l (p < 0.001). Women with an acute phase response also had lower serum selenium (by 5.6 μg/l, p = 0.06). Serum selenium was independently associated with serum
Results There were 42 female and 31 male patients with an age range of 18-54 years. In the comparison of laboratory parameters of the patients with or without the components of BDCAF, no significant relation could be found between headache, erythema nodosum, superficial thrombophlebitis, skin pustules, GIS and eye involvement and acute phase response parameters. However, we found significantly higher levels of ferritin in patients with arthritis and higher levels of fibrinogen in patients both with arthralgia and arthritis versus without joint involvement (p=0,01; p=0,030 and p=0,000; respectively). Also Hp levels in patients with genital ulceration and arthritis (p=0,005 and p=0,002) and Cp levels in patients with oral ulceration and arthritis were found to be higher compared to patients without these involvements (p=0,01 and p=0,001). Prealbumin as a negative acute phase reactant was determined as significantly lower in patients with joint involvement than the patients without it (p=0,023). ...
TY - JOUR. T1 - Characterization of ionic liquid‐based biocatalytic two‐phase reaction system for production of biodiesel. AU - Prabhavathi Devi, Bethala Lakshmi Anu. AU - Guo, Zheng. AU - Xu, Xuebing. PY - 2011. Y1 - 2011. N2 - The property of a variety of ionic liquids (ILs) as reaction media was evaluated for the production of biodiesel by enzymatic methanolysis of rapeseed oil. The IL Ammoeng 102, containing tetraaminum cation with C18 acyl and oligoethyleneglycol units, was found to be capable of forming oil/IL biphasic reaction system by mixing with substrates, which is highly effective for the production of biodiesel with more than 98% biodiesel yield and nearly 100% conversion of oil. Conductor‐like screening model for real solvent (COSMO‐RS) in silico prediction of substrate solubility and simulation of partition coefficient change vs. reaction evolution indicated that the amphiphilic property of Ammoeng 102 might be responsible for creating efficient interaction of immiscible ...
Kaori Maeda, Luke O. Schoeniger, Masahiko Shimada, Richard A. Winchurch, Timothy G. Buchman, James L. Robotham; Regulation of Acute Phase Gene Expression Following Surgery and Endotoxin Administration in the Anesthetized Pig. Anesthesiology 1993;79(6):1324-1337. Download citation file:. ...
1. It has been suggested that the physiological consequences of strenuous exercise are analogous to those of the acute-phase response.. 2. In 70 male and 20 female competitive distance runners, a marked, but transient, neutrophil leucocytosis occurred immediately after these athletes completed a standard (42 km) marathon race. Concomitant significant increases were noted in the plasma cortisol levels, creatine kinase activity, C-reactive protein level, total protein level and albumin level (P ,0.01).. 3. The plasma fibrinogen, C-reactive protein and total protein concentrations were markedly increased both 24 h and 48 h after exercise (P ,0.01). The serum haptoglobin level was significantly decreased after exercise (P ,0.01), and increased 48 h later (P ,0.05). There was no change in the serum iron level, total iron-binding capacity, per cent saturation of transferrin and serum ferritin level.. 4. A significant increase in interleukin-1-type activity was demonstrated immediately and 24 h after ...
L~..Lary IUeurotroph~cPactor: Pharmacokrnetics m-d Acute-Phase Response in Rat Falk Dittrich, Hans Thoenen, and Michael Sendtnet Ciliary neurotrophic factor (CNTF) supports the survival of motoneurons in vitro and in vivo. Recombinant CNTF is an investigational drug for the treatment of amyotrophic lateral sclerosis. We determined the pharmacokinetics of radioiodinated CNTF after intravenous injection into rats. CNTF shows a biphasic clearance with an initial plasma half-life of 2.9 minutes and is removed from the circulation by the liver. No accumulation of radioactivity was detectable in nerve tissue or skeletal muscle after intravenous injection of 0.1 pg and 0.5 pg of CNTF. Radioactive degradation products accumulate in the skin. Liver cells express specific binding proteins for CNTF, and the incorporation and degradation of intravenously injected CNTF by the liver may occur after association of CNTF with the soluble CNTF receptor cu in the circulation. Probably a9 a consequence of its ...
You may also wish to search for items by Bierbaum, V. and Bierbaum. 57 matching references were found. Bierbaum, V.M.; DePuy, C.H.; Shapiro, R.J., Gas phase reactions of anions with nitrous oxide and carbon dioxide, J. Am. Chem. Soc., 1977, 99, 5800. [all data] DePuy, C.H.; Bierbaum, V.M.; Schmitt, R.J.; Shapiro, R.H., Gas phase oxidation and reduction reactions with C6H7-, HNO-, and HO2-, J. Am. Chem. Soc., 1978, 100, 2970. [all data] Schmitt, R.J.; Bierbaum, V.M.; DePuy, C.H., Gas phase reactions of carbanions with triplet and singlet molecular oxygen, J. Am. Chem. Soc., 1979, 101, 6443. [all data] DePuy, C.H.; Bierbaum, V.M.; Flippin, L.A.; Brabowski, J.J.; King, G.K.; Schmidt, R.J.; Sullivan, S.A., Gas phase reactions of anions with substituted silanes, J. Am. Chem. Soc., 1980, 102, 5012. [all data] Bierbaum, V.M.; Schmidt, R.J.; DePuy, C.H.; Mead, R.H.; Schulz, P.A.; Lineberger, W.C., Reactions of carbanions with triplet and singlet molecular oxygen, J. Am. Chem. Soc., 1981, 103, 6262. [all ...
The serum protein 1-acid glycoprotein (AGP), also known as orosomucoid, is normally referred to as an archetypical positive acute phase protein. as analyzed by 2-D electrophoresis. This MAb was utilized to build up an immunoassay (ELISA) for quantification of AGP in pig serum samples. The adult serum concentrations of pig AGP had been in the number of 1C3 mg/ml in several regular pig breeds although it was low in G?ttingen and Ossabaw minipigs (in the 0.3 to 0.6 mg/ml vary) and higher in young (2C5 times old) regular pigs (mean: 6.6 mg/ml). Amazingly, pig AGP was discovered to Betanin work as a poor acute phase proteins during a selection of experimental infections and aseptic irritation with significant decreases in serum focus and in hepatic ORM1 expression through the acute stage response. To your understanding this is actually the first explanation in virtually any species of AGP being truly a negative severe phase protein. Launch Alpha-1-acid glycoprotein (AGP), also referred to as ...
Turpentine or Turpentine oil is a liquid derived from the distillation of pine tree species and has industrial and pharmaceutical uses. Their organic matter is
The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections. We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers ...
C-reactive protein is a serum acute-phase reactant that increases several thousand-fold in concentration during inflammation in most mammals. However, mouse C-reactive protein is considered to be a minor acute-phase reactant, since its blood level increases only from approx. 0.1 to 1-2 micrograms/ml. A mouse genomic clone of approximately 5 kb was obtained to determine the molecular basis for the regulation of the expression of mouse C-reactive protein. Several cis-acting elements in the 5′ flanking region that potentially regulate transcription were identified: two glucocorticoid-responsive elements, two CCAAT-enhancer-binding protein C (C/EBP) consensus elements that are required for the interleukin-1 responsiveness of some acute-phase reactant genes, an interleukin-6-responsive element, two hepatocyte nuclear factor-1 (HNF-1) elements and a single heat-shock element. Transfection of the hepatoma cell line Hep 3B.2 with a pCAT expression vector containing the 5′ flanking sequence from ...
IndianOils cross-country network of crude Oil and product pipelines is spread over 10,000 Km. The Corporation handles the largest network of petrol and diesel stations in the country.
The principal aim of this study was to improve the laboratory diagnosis of inflammation in farmed red deer, primarily through the investigation of blood cells and inflammatory proteins in a variety of inflammatory conditions. The objectives were: 1) To establish solidly based reference values for haematological parameters and certain acute phase proteins, including fibrinogen, that may be useful in detecting and assessing infection in red deer. 2) To investigate various factors that might affect the results for these parameters, such information being essential for correct interpretation of test results. 3) To investigate aspects of the acute phase response in red deer. 4) To investigate changes in the above parameters in deer in a selection of infections. 5) To explore the observed responses in terms of possible functions of the components by reference to the literature. Despite a lower content of myeloperoxidase in deer leucocytes, automated leucocyte differential equipment (Technicon H6000/C) ...
Diabetes mellitus is one of public health problem in world. Type 2 diabetes millitus (T2DM) which resistance cell to insulin. more inflammation occur in Patients with T2DM because of elevation of inflammatory marker like C3, C4 & hsCRP. This study was aimed to detect the level of acute phase reactant proteins (C3 , C4 and hsCRP) in T2DM patients. Blood samples were collected from 60 patients with T2DM and control group was included 30 healthy donors. C3, C4 & hsCRP levels were estimated for all samples. Samples were grouped according to complications of patients. The results showed that there was a significant increase in C3 level for patients with T2DM (199.0 mg/dl) compared to control group (135.4 mg /dl) while C4 level for T2DM (27.25 mg/dl) showed no significant change compared to control group( 30.04mg/dl). C3 level of patients under heart disease (199.6 mg/dl ), patients under thyroid disease (230.4 mg/dl) and patients without any disease (188.1 mg/dl) recorded significant elevation
CRP is an acute-phase plasma protein that increases during systemic inflammation. CRP is produced primarily in the liver and is regulated by proinflammatory cytokines, especially IL-6. In turn, we have shown here that CRP induces the release of IL-6 by PBMC and purified CD14+ monocytes, envisioning a feed-forward loop between CRP and IL-6. CRP levels in blood are normally very low and difficult to detect in healthy individuals, but increase rapidly with inflammation. Increased CRP concentrations have been reported in many diseases, including cardiovascular diseases, diabetes, inflammatory bowel diseases, arthritis, and many cancers. With respect to the CRP association with cancer (45), the robust association described between circulating levels of CRP and cancer risk suggest alternative possibilities: (i) elevated CRP might have a causal role in carcinogenesis, (ii) elevated CRP levels might be the result of an underlying cancer, and (iii) a third factor, such as chronic inflammation, might ...
Figure 1- The components of the innate immune system. Sentinel cells such as the macrophage detect potential environmental threats from infection, chemicals, and foods by PRRs that activate signaling pathways and release proinflammatory cytokines (IL-6 and TNF-α). Known PRRs include TLR-4, which senses bacterial LPS and the receptor for AGEs. Cytokines stimulate acute-phase protein production from the liver and also act on the brain to release adrenocorticotrophic hormone (and thereby cortisol from the adrenal gland) and activate the sympathetic nervous system with the release of catecholamines. Psychological stress can cause an acute-phase response via innervation of cytokine-producing cells and via activation of the sympathetic nervous system and adrenergic receptors on macrophages. Central cytokine-induced sickness behavior includes lethargy, sleep changes, and depression. The innate immune system also controls the adaptive (acquired) immune system via costimulatory molecule expression ...
Turpentine is an old folk remedy used for centuries to keep Candida in check. Learn which type of Turpentine is safe for human consumption, proper dosing, and an additional ingredient you must add to the Turpentine for it to be effective.
ABSTRACT C-reactive protein (CRP), an acute-phase plasma protein, is a major component of inflammatory reactions functioning as a… Expand ...
APRs add little information on top (and independent) of the combination of clinical variables included in the SDAI. A purely clinical score is a valid measure of disease activity and will have its greatest merits in clinical practice rather than research, where APRs are usually always available. The …
A.Groisman, C.Lobo, H.Cho, JK Campbell, YS Dufour, AM Stevens, A Levchenko, A microfluidic chemostat for experiments with bacterial and yeast cells, Nature Methods. 2005 Sep; 2(9):685-9. BK Cho, H Cho, H Yun, BG Kim, Simultaneous synthesis of enantiomerically pure (S)-amino acids and (R)-amines using /-aminotransferase coupling reactions with two-liquid phase reaction system, Journal of Molecular Catalysis B: Enzymatic, 2003 December 1; 26(3):273-85 BK Cho, H.Cho, SH Park, H Yun, BG Kim, Simultaneous synthesis of enantiomerically pure (S)-amino acids and (R)-amines using coupled transaminase reactions, Biotechnology and Bioengineering. 2003 Mar 30; 81(7):783-9 ...
Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma: DC Activation Occurs in the Airway Mucosa but Not in the Lung ...
Table 1 Heating of organic solvents by microwaves (50cm3, 560Watts for 1 minute). Superheating, which may result in boiling points being raised by up to 20oC above their conventional value under microwave irradiation (see Table 2 below), is widely believed to be responsible for the rate and yield increases which accompany many liquid phase reactions. Reports by a number of workers have suggested that other mechanisms peculiar to microwaves are responsible for some enhanced reactions, and these will be considered in other sections.. ...
FSS Protein Serum M is not your typical protein! It may be as a superior film former to instantly moisturize the skin while also functioning as an anti-aging product to tighten the skin...
The proinflammatory cytokine Interleukin 1 beta (IL-1) is elevated in obese individuals and rodents which is implicated in impaired insulin secretion, decreased cell proliferation and apoptosis of pancreatic beta cells. amyloid A (SAA) which is an indication Cd247 of inflammation-induced acute phase response (*= 0.024). While there was no improvement of obesity, a significant improvement of glycemic control and of beta cell function is definitely achieved by this pharmacological treatment which may sluggish/prevent disease progression in Type 2 Diabetes. within the development of obesity, swelling, and insulin resistance inside a mouse model of diet-induced obesity, which appear to mimic human being disease more closely than genetic mouse models of obesity. To specifically address the part of IL-1 in obesity, we used an anti- mouse IL-1 monoclonal antibody (37) with shown activity (38). Earlier studies have used recombinant IL-1Ra which blocks the biological activity on IL-1 receptor of both ...
The NFκB pathway is complex and regulates many downstream effects depending on the type of stimulating ligand and cell context. [13] TLR9 can be activated by mycobaterial DNA. Further, intracellular viral ssRNA and dsRNA activate the inflammation that induces cleavage of the pro-form of IL-1β into its mature active form.95 In fact, mice lacking the TLR3, which recognizes dsRNA and activates cytokine synthesis, if infected with mouse-adapted influenzavirus have attenuated increases in NREM sleep, hypothermia, and body weight loss compared to the prototypical responses of normal mice infected with influenza.96 Further, intracellular dsRNA that is produced during viral replication is also recognized by cytoplasmic PAMPs.97 Thus, PAMPs play a crucial role in the recognition of pathogens that lead to the production of sleep regulatory cytokines and the acute phase response to infections. Potentially, mitochondria simply act as a physical scaffold that promotes inflammasome assembly. By continuing ...
Human C-reactive protein is an acute phase protein whose blood concentrations rise dramatically in response to inflammatory insults. Though CRP is primarily of...
The NF-κB family of transcription factors are conserved from flies to humans and regulate the expression of a wide variety of cellular and viral genes (reviewed in reference (1)). Biochemical and molecular characteristics of NF-κB and their activation pathways have been extensively studied, especially in terms of immune and acute phase responses. The mammalian NF-κB proteins, RelA (p65), c-Rel, RelB, p50/p105, and p52/p100, share the rel homology domain which facilitates dimerization, nuclear translocation and DNA binding. Transactivation domains are also present at the COOH termini of RelA, c-Rel, and RelB. These NF-κB proteins form multiple interchangeable heterodimers and homodimers and their activity is regulated by binding of IκB inhibitory factors which determine the localization of NF-κB dimers, either in the cytoplasm or in the nucleus. Upon activation, NF-κB dimers dissociate from IκB and translocate to the nucleus and then bind to the κB sites in promoters and enhancers of ...
Need more information about Report Methodology? Click here- https://www.factmr.com/connectus/sample?flag=RM&rep_id=4435. Country-specific assessment on demand for crude sulfate turpentine has been provided for each regional market, along with the market size valuation and forecast price point assessment, price index and impact analysis of key regional and country-wise dynamics, which were obtained through quotes from numerous crude sulfate turpentine manufacturers, experts, and suppliers. Y-o-Y growth projections have also been offered on all regional markets incorporated in the report. Moreover, future trends, growth prospects, and other possibilities related to the market have been answered in the report.. The report provides company-level market share analysis, which has been derived on the basis of the companys annual sales and segmental revenue in all the target end-use industries. The market has been forecasted based on constant currency rates. The report provides detailed competitive and ...
Definition : Immunoassay reagents intended to perform qualitative and/or quantitative analyses of body fluids (typically serum) to determine the protein alpha-1-acid glycoprotein (AAG), also known as orosomucoid. AAG is a plasma protein whose concentration rises significantly during acute inflammatory processes (i.e., it is an acute-phase reactant). Some causes of acute inflammatory responses include surgery, myocardial infarction, infections, and/or tumors. Increased levels of AAG typically occur within 12 hours of the injury and decrease in 4 or 5 days.. Entry Terms : Orosomucoid Determination Reagents , Alpha-1-Acid Glycoprotein (AAG) Determination Reagents , AAG (Alpha-1-Acid Glycoprotein) Determination Reagents , Reagents, Alpha-1-Acid Glycoprotein , Reagents, Immunoassay, Protein, Alpha-1-Acid Glycoprotein. UMDC code : 17256 ...
Turpentine is a perzine by Ilana. It is defined as a cut and paste zine that features music and zine reviews, band interviews, and other odds and ends. Issue five featured an interview with Dame Darcy. The seventh issue was published in 2005. ...
Linear regression is then employed for no better reason than that users know how to type lm but not gam C Shalizi http://j.mp/hHYVIu (pdf) (h/t mja, 14 Apr ...
This Table of Contents lists column numbers, headings, time lines and names of Members in the Commons Hansard Debates text for ...
Leukemoid reaction Acute phase reaction Betty Ciesla (27 November 2018). "Chapter 10: Abnormalities of white blood cells: ...
Cytokines help stimulate the acute phase reaction in response to inflammation. Colchicine inhibits macrophage production of TNF ...
... effect on the acute phase reaction". Z Ernahrungswiss. 37 Suppl 1: 43-9. PMID 9558728. Schieven GL, Kallestad JC, Brown TJ, ... OSM can regulate the expression of acute phase proteins. OSM regulates the expression of various protease and protease ... "Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal ...
C-reactive protein (CRP) is an acute phase protein. Therefore, it is a better marker for acute phase reaction than ESR. While ... In some parts of the world the test continues to be referred to as Biernacki's Reaction (Polish: odczyn Biernackiego, OB). In ... ESR begins to rise at 24 to 48 hours after the onset of acute self-limited inflammation, decreases slowly as inflammation ...
Van Cott EM, Smith EY, Galanakis DK (August 2002). "Elevated fibrinogen in an acute phase reaction prolongs the reptilase time ...
He identified IL-6 as a hepatocyte stimulating factor which induces acute phase reactions. He prepared a monoclonal anti-IL-6 ... withdrawal phase III trial. Lancet 371(9617):998-1006, 2008 Kishimoto, T. Interleukin-6: From basic science to medicine, 40 ...
A normal C-reactive protein can be used to exclude elevated ferritin caused by acute phase reactions.[citation needed] Ferritin ... Ong DS, Wang L, Zhu Y, Ho B, Ding JL (2005). "The response of ferritin to LPS and acute phase of Pseudomonas infection". ... Beck G, Ellis TW, Habicht GS, Schluter SF, Marchalonis JJ (January 2002). "Evolution of the acute phase response: iron release ... As ferritin is also an acute-phase reactant, it is often elevated in the course of disease. ...
... term effects of the TNFα antagonist infliximab on the acute phase reaction and activities of daily life in patients with ...
... of prednisolone and a protein-deficient diet on plasma albumin and fibrinogen in a turpentine-induced acute-phase reaction in ... "Hepatocyte growth factor: a regenerative drug for acute hepatitis and liver cirrhosis". Division of Molecular Regenerative ...
HANSON , D.A. MEIRA .,ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL. ...
In the acute phase reaction, a further elevation is required to "limit" the damage caused by activated neutrophil granulocytes ... Kushner, Mackiewicz A (1993). The acute phase response: an overview. Acute-phase glycoproteins: molecular biology, biochemistry ... but the concentration can rise manyfold upon acute inflammation. When the blood contains inadequate amounts of A1AT or ...
Fever and an increased white blood cell count are features of the acute-phase reaction, while an increased heart rate is often ... The complications of SIRS include Acute kidney injury Shock Multiple organ dysfunction syndrome The causes of SIRS are broadly ... Patients with SIRS and acute organ dysfunction may be termed "severe SIRS." Note: ...
... a resonant absorption effect used in magnetic resonance spectroscopy Acute phase reaction, a reaction due to the presence of ... guideline Accreditation in Public Relations Acute phase reactant, a class of proteins Adleman-Pomerance-Rumely primality test ...
Systemic inflammatory reaction results in stimulation of four major programs: the acute-phase reaction sickness behavior the ... They included studies of acute laboratory stressors (e.g. a speech task), short-term naturalistic stressors (e.g. medical ... Selye describes three stages of adaptation, including an initial brief alarm reaction, followed by a prolonged period of ... Like the stress response, the inflammatory reaction is crucial for survival. ...
Increase in phospholipase A2 activity is an acute-phase reaction that rises during inflammation, which is also seen to be ... "Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice". The Journal of ... and has been shown to promote vascular inflammation correlating with coronary events in coronary artery disease and acute ... "Secretory phospholipase A₂ pathway during pediatric acute respiratory distress syndrome: a preliminary study". Pediatric ...
... are elevated in these clinical states as part of the acute phase reaction. High platelet counts can occur in patients with ... In adults, acute infection, tissue damage, chronic inflammation and malignancy are the common causes of reactive ...
... acute phase reactions, and hematopoiesis. Researchers are interested in the potential of small-molecule inhibitors (such as the ...
... the amount of StAR available to transfer cholesterol to the inner membrane limits how fast the reaction can go (the acute phase ... This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of ... This step is mediated primarily by the steroidogenic acute regulatory protein (StAR or STARD1). Upon stimulation of a cell to ... A study of the steroidogenic capacity of the adrenal cortex in infants with acute respiratory disease demonstrated that indeed ...
This response is called the acute-phase reaction (also called acute-phase response). The acute-phase reaction ... The terms acute-phase protein and acute-phase reactant (APR) are often used synonymously, although some APRs are (strictly ... Acute-phase proteins (APPs) are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or ... acute-phase reactants. Increased acute-phase proteins from the liver may also contribute to the promotion of sepsis. TNF-α, IL- ...
... herpetic phase is characterized by when viral particles infiltrate the retina and vitreous causing an inflammatory reaction. ... ARN presentation in individuals can be characterized by two separate phases as listed below. The acute ... "Acute retinal necrosis - EyeWiki". eyewiki.aao.org. Retrieved 2015-10-27. CS1 maint: discouraged parameter (link) "Acute ... exposing a patient to antiviral agents in the earlier phases of the outbreak tend to decrease the duration of the active phase ...
This can occur for years until the inflammatory reaction rises again. In the inflammatory (acute) phase, the antigens from the ... Microfilariae are not normally present in this phase. A key feature of this phase is scar formation from affected tissue areas ... A polymerase chain reaction test can also be performed to detect a minute fraction, as little as 1 pg, of filarial DNA. Some ... The asymptomatic phase usually consists of high microfilaremia infection, and individuals show no symptoms of being infected. ...
Late-phase response[edit]. After the chemical mediators of the acute response subside, late-phase responses can often occur due ... This phase can either subside or progress into a "late-phase reaction" which can substantially prolong the symptoms of a ... The reaction is usually seen 2-24 hours after the original reaction.[41] Cytokines from mast cells may also play a role in the ... Skin tests cannot predict if a reaction would occur or what kind of reaction might occur if a person ingests that particular ...
Acute-phase reaction. *Vasodilation. *Increased vascular permeability. *Exudate. *Leukocyte extravasation. *Chemotaxis. Tests. ...
Acute-phase reaction/Fever. *Vasodilation. *Increased vascular permeability. *Exudate. *Leukocyte extravasation. *Chemotaxis ... The most common causes of acute bacterial conjunctivitis are Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus ... Acute conjunctivitis is most frequently found in infants, school-age children and the elderly.[12] The most common cause of ... "Acute Bacterial Conjunctivitis - Eye Disorders - Merck Manuals Professional Edition". Merck Manuals Professional Edition. ...
Acute-phase reaction/Fever. *Vasodilation. *Increased vascular permeability. *Exudate. *Leukocyte extravasation. *Chemotaxis ... acute. Acute bronchitis. chronic. COPD Chronic bronchitis. Acute exacerbations of chronic bronchitis. Acute exacerbation of ... "Acute Bronchitis , Bronchitis Symptoms , MedlinePlus". Retrieved 2017-11-30.. *^ a b Goldsobel, AB; Chipps, BE (March 2010). " ... acute and chronic.[1] Acute bronchitis is also known as a chest cold.[1] ...
Acute-phase reaction/Fever. *Vasodilation. *Increased vascular permeability. *Exudate. *Leukocyte extravasation. *Chemotaxis ...
Acute-phase reaction/Fever. *Vasodilation. *Increased vascular permeability. *Exudate. *Leukocyte extravasation. *Chemotaxis ... Polymerase chain reaction (PCR) testing of the cerebrospinal fluid, to detect the presence of viral DNA which is a sign of ... Viral encephalitis can occur either as a direct effect of an acute infection, or as one of the sequelae of a latent infection. ... The number of new cases a year of acute encephalitis in Western countries is 7.4 cases per 100,000 people per year. In tropical ...
Acute-phase reaction/Fever. *Vasodilation. *Increased vascular permeability. *Exudate. *Leukocyte extravasation. *Chemotaxis ... The phases of the leukocyte extravasation depicted in the schema are: approach, capture, rolling, activation, binding, ... This increases the initial leukocyte rolling speed, prolonging the slow rolling phase. ...
Acute-phase reaction/Fever. *Vasodilation. *Increased vascular permeability. *Exudate. *Leukocyte extravasation. *Chemotaxis ... Does this adult patient have acute meningitis?". JAMA. 282 (2): 175-81. doi:10.1001/jama.282.2.175. PMID 10411200.. ... Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known collectively as the ... Polymerase chain reaction (PCR) is a technique used to amplify small traces of bacterial DNA in order to detect the presence of ...
Allergic Sensitization - There is an acute response (early stages) and a late-phase response (later stages). In the early ... Tests that are commonly used place potential allergens on the skin of the patient and looking for a reaction to look for an ... IgE circulates around and binds to receptors of cells leading to an acute inflammatory response.[13] In this case, ...
The response to the epidemic then moved to a second phase, as the focus shifted from slowing transmission to ending the ... Non-infectious diseases that may result in symptoms similar to those of EVD include acute promyelocytic leukaemia, haemolytic ... detecting the viral RNA by polymerase chain reaction (PCR)[6][23] and detecting proteins by enzyme-linked immunosorbent assay ( ... "The Ebola epidemic ravaging parts of West Africa is the most severe acute public health emergency seen in modern times. Never ...
Results of a Phase 2, Dose-Ranging Study". Journal of Drugs in Dermatology. 17 (3): 333-338. PMID 29537451.. ... If the inflammatory reaction is severe, the follicle can break into the deeper layers of the dermis and subcutaneous tissue and ... Their use during pregnancy has been associated with the development of acute fatty liver of pregnancy and is further avoided ... Phase 3, Randomized, Double-Blind Clinical Trials". Journal of Drugs in Dermatology. 17 (9): 987-996. PMID 30235387.. ...
Severe infusion reaction.. *Cardiac arrest. *Cytokine release syndrome. *Tumor lysis syndrome, causing acute renal failure ... Hepatitis E infection is normally an acute infection, suggesting the drug in combination with lymphoma may have weakened the ...
Acute overdose may cause fever, hypoglycemia, heart failure, coma, and unrecognized adrenal insufficiency. ... Allergic reactions to the drug are characterized by symptoms such as difficulty breathing, shortness of breath, or swelling of ... Acute massive overdose may be life-threatening; treatment should be symptomatic and supportive. Massive overdose can be ... people with acute myocardial infarction, and people with thyrotoxicosis of any etiology.[15] Levothyroxine is also ...
Spinal manipulation may be cost-effective for sub-acute or chronic low back pain but the results for acute low back pain were ... Hurwitz EL, Morgenstern H, Vassilaki M, Chiang LM (July 2005). "Frequency and clinical predictors of adverse reactions to ... BEIR VII Phase 2. Washington, DC: The National Academies Press. ISBN 0-309-09156-X.. CS1 maint: Multiple names: authors list ( ... There is moderate quality evidence to support the use of SM for the treatment of acute lumbar radiculopathy[101] and acute ...
Reaction with water On reaction with water, they generate hydroxide ions and hydrogen gas. This reaction is vigorous and highly ... Various phases are known, such as LiB10, NaB6, NaB15, and KB6.[111][112] Under high pressure the boron-boron bonding in the ... Johnson, Garland T.; Lewis, Trent R.; Wagner, D. Wagner (1975). "Acute toxicity of cesium and rubidium compounds". Toxicology ... Representative reactions of alkali metalsEdit. Reaction with oxygen Upon reacting with oxygen, alkali metals form oxides, ...
GAC is designated by sizes such as 8×20, 20×40, or 8×30 for liquid phase applications and 4×6, 4×8 or 4×10 for vapor phase ... Stőhr B.; Boehm H.P.; Schlőgl R. (1991). "Enhancement of the catalytic activity of activated carbons in oxidation reactions by ... Oxidation in the liquid phase is caused by a wide range of reagents (HNO3, H2O2, KMnO4).[40][41][42] ... In vapour phase systems this needs to be considered against pressure drop, which will affect energy cost. Careful consideration ...
Serologically, an enzyme-linked immunosorbent assay during the acute phase of the disease using specific IgM against yellow ... A direct confirmation can be obtained by reverse transcription polymerase chain reaction, where the genome of the virus is ... Different methods for acute treatment of the disease have been shown not to be very successful; passive immunization after the ... In 15% of cases, though, people enter a second, toxic phase of the disease with recurring fever, this time accompanied by ...
Acute toxicity: The oral LD50 values in mouse and rat are quite high, indicating a wide therapeutic index. LD50 for mice is 730 ... except that in doses of 400 mg or higher peripheral reaction time may be impaired.[68] Peripheral oedema has been associated ... Bech P (August 1993). "Acute therapy of depression". J Clin Psychiatry. 54 Suppl: 18-27, discussion 28. PMID 8253702.. ... none experienced a tyramine-mediated hypertensive reaction.[64] As the pressor effect of moclobemide is so low, dietary ...
Music is useful in the recovery of motor skills.[38] In a study on stroke patients in the recovery phase, music therapy was ... This category can be used when the focus of clinical attention is a reaction to the death of a loved one. As part of their ... Music therapy may provide a means of improving mental health among people with schizophrenia, but its effects in acute ... However, the presence of certain symptoms that are not characteristic of a "normal" grief reaction may be helpful in ...
Commercial Scale Demonstration of the Liquid Phase Methanol Process, Dept. of Energy Production of methanol by Clean Coal power ... 1] University of Cambridge, General Management of Acute Poisoning, Specific Poisonings: Methanol ... requiring the use of methanol fuel to react in a catalytic reaction with the coiled platinum filament in a glow plug for the ... and may cause phase separation of methanol-gasoline blends, containers of methanol fuels must be kept tightly sealed. ...
The dietary focus on chemical elements derives from an interest in supporting the biochemical reactions of metabolism with the ... Momcilović, B. (September 1999). "A case report of acute human molybdenum toxicity from a dietary molybdenum supplement-a new ... or when chronic or acute deficiencies arise from pathology, injury, etc. Research has supported that altering inorganic mineral ...
Many classes of chemical reactions, such as Diels-Alder reactions and Friedel-Crafts reactions, can be performed using ionic ... C Pretti; C Chiappe; D Pieraccini; M Gregori; F Abramo; G Monni & L Intorre (2006). "Acute toxicity of ionic liquids to the ... Mota-Martinez M. T.; Althuluth M.; Berrouk A.; Kroon M.C.; Peters Cor J. (2014). "High pressure phase equilibria of binary ... Aza-Baylis-Hillman reaction for the use of a chiral ionic liquid in asymmetric synthesis. ...
Topical, oral, and intravenous use of fluorescein can cause adverse reactions, including nausea, vomiting, hives, acute ... The lifetimes can be recovered using time-correlated single photon counting or phase-modulation fluorimetry. ... The risk of an adverse reaction is 25 times higher if the person has had a prior adverse reaction.[19] The risk can be reduced ... The most common adverse reaction is nausea, due to a difference in the pH from the body and the pH of the sodium fluorescein ...
It is therefore used to indicate deep-vein thrombosis, pulmonary embolism, DIC and efficacy of treatment in acute myocardial ... avoid the use of blood products such as fresh frozen plasma with its associated risks of infections or anaphylactic reactions. ...
... phase I trials - phase II trials - phase III trials - phase IV trials - photosensitivity - PHS - pituitary gland - placebo - ... acute HIV infection - Acute HIV Infection and Early Diseases Research Program (AIEDRP) - ADAP - ADC - adenopathy - adherence - ... Polymerase chain reaction (PCR) - polyneuritis - polypeptide - polyvalent vaccine - post-exposure prophylaxis (PEP) - PPD test ... adjuvant - administration - Adult AIDS Clinical Trials Group (AACTG) - adverse drug reaction - aerosolized - AETC - ...
... acute phase of malaria) ... also the predominant inflammatory cells in allergic reactions. ... Blood cell dysfunction - megaloblastic anemia, myelodysplasia, marrow failure, marrow replacement, acute leukemia ... Neutrophils are the most common cell type seen in the early stages of acute inflammation. The average lifespan of inactivated ... severe acute pancreatitis, sarcoidosis, protein-losing enteropathy, strenuous exercise, carcinoma ...
In the acute phase of ALI, there is increased permeability of this barrier and protein rich fluid leaks out of the capillaries ... Inhalation of high doses of this gas causes lesions in the larynx, trachea, and large bronchi with inflammatory reactions and ... 2007) Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future ... 2008) Animal models of acute lung injury. Am J Physiol. 295:L379-99. Li X, Li S, Zhang M, Li X, Zhang X, Zhang W, Li C. (2010) ...
F43) Reaction to severe stress, and adjustment disorders *(F43.0) Acute stress reaction ... Advanced sleep phase disorder. *Delayed sleep phase disorder. *Irregular sleep-wake rhythm ... F23) Acute and transient psychotic disorders *(F23.0) Acute polymorphic psychotic disorder without symptoms of schizophrenia ... F23.1) Acute polymorphic psychotic disorder with symptoms of schizophrenia. *(F23.2) Acute schizophrenia-like psychotic ...
Acute Phase. The goals of treatment during the acute phase of treatment, defined by an acute psychotic episode, are to prevent ... Check for reactions to traumatic experiences. *Decide together with a doctor about using medication, taking into account the ... Stable Phase. The goals of treatment during the stable phase are to ensure that symptom remission or control is sustained, that ... Stabilization Phase. During the stabilization phase, the goals of treatment are to reduce stress on the patient and provide ...
2) The biomarker levels must be elevated in various forms and/or severities of human TBI in the acute phase (3-24 h post-injury ... The most extreme case would be to detect mutant proteins as cancer specific biomarkers through Selected reaction monitoring ( ... Temporal protein biomarkers in tracking different phases of TBIEdit. A continuum of protein biomarkers in tracking different ... For example, it is now recognized that the pathophysiology of TBI is not only acute event, but is also a progressive and ...
Positive results in small phase II studies in humans could also be misleading and lead to failure in phase III trials. Other ... "Ice Bucket Challenge: Lady Gaga, Justin Bieber, G-Dragon and Oprah - the most entertaining reactions so far".. ... An analysis of 23 large phase II and phase III RCTs that failed between 2004 and 2014 concluded that there were many potential ... It is unclear exactly when the end-of-life phase begins in ALS, but it is associated with significant difficulty moving, ...
Earlier cell cycle checkpoints such as post-restriction point check between G1 phase and S phase similarly involve proteasomal ... The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin ... for B-cell acute lymphoblastic leukemia [109] Proteasome inhibitors can kill some types of cultured leukemia cells that are ... Enzymes that help such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the ...
Many acute-phase proteins of inflammation are involved in the coagulation system. ... serious allergic reactions that can cause death).[4] When activated, mast cells rapidly release characteristic granules, rich ... The process of acute inflammation is initiated by cells already present in all tissues, mainly resident macrophages, dendritic ... a phase I trial". Cytotherapy. 10 (6): 625-32. doi:10.1080/14653240802301872. PMID 18836917.. ...
Levine M, Dhariwal KR, Washko P, Welch R, Wang YH, Cantilena CC, Yu R (1992). "Ascorbic acid and reaction kinetics in situ: a ... so it exhibits remarkably low acute toxicity.[4] More than two to three grams may cause indigestion, particularly when taken on ... "Measurement of intracellular vitamin C levels in human lymphocytes by reverse phase high performance liquid chromatography ( ... Vitamin C functions as a cofactor in many enzymatic reactions in animals (and humans) that mediate a variety of essential ...
... involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by ... On the liver: stimulating the acute phase response, leading to an increase in C-reactive protein and a number of other ... To study whether acute exercise induces a true anti-inflammatory response, a model of 'low grade inflammation' was established ... This study provides some evidence that acute exercise may inhibit TNF production.[41] ...
Acute side effects[edit]. Nausea and vomiting. This is not a general side effect of radiation therapy, and mechanistically is ... Nerve damage from ionizing radiation occurs in phases, the initial phase from microvascular injury, capillary damage and nerve ... The reaction may become more severe during the treatment and for up to about one week following the end of radiation therapy, ... Skin reactions tend to be worse in areas where there are natural folds in the skin, such as underneath the female breast, ...
Delayed sleep phase disorder (DSPD), inability to awaken and fall asleep at socially acceptable times but no problem with sleep ... An allergic reaction over produces histamine causing wakefulness and inhibiting sleep[21] Sleep problems are common in people ... In one particular study, participants (18 years or older) who had experienced acute or chronic sleep disorders were put in a ... Other such disorders are advanced sleep phase disorder (ASPD), non-24-hour sleep-wake disorder (non-24) in the sighted or in ...
Routine exercise alters measures of immunity and the acute phase reaction.. Horn PL1, West NP, Pyne DB, Koerbin G, Lehtinen SJ ... More than 10 % of observed acute phase reactant values (for C3, haptoglobin and ferritin) were also below the low end of the ... This information would be useful for clinicians interpreting blood tests assessing inflammatory, immune and acute phase ... Samples were analysed for 20 cellular and non-cellular biomarkers which included 11 immunological and 9 acute phase reactants. ...
Encyclopedia , Acute phase reaction. Acute phase proteins are a class of proteins that are synthetized in the liver in response ... Because the acute phase response is relatively non-specific, the value of measuring acute-phase protein concentrations is to ... This response is called the acute phase reaction.. In response to injury, local inflammatory cells (neutrophil granulocytes and ... TNFα is a member of a group of other cytokines that all stimulate the acute phase reaction. ...
What is Acute-phase reaction? Meaning of Acute-phase reaction medical term. What does Acute-phase reaction mean? ... Looking for online definition of Acute-phase reaction in the Medical Dictionary? Acute-phase reaction explanation free. ... acute phase protein. (redirected from Acute-phase reaction). Also found in: Encyclopedia. acute phase protein. plasma proteins ... Acute-phase reaction , definition of Acute-phase reaction by Medical dictionary https://medical-dictionary.thefreedictionary. ...
What is acute phase reaction? Meaning of acute phase reaction medical term. What does acute phase reaction mean? ... Looking for online definition of acute phase reaction in the Medical Dictionary? acute phase reaction explanation free. ... Synonym(s): acute phase response. acute phase reaction. The release of physiologically active proteins by the liver into the ... Acute phase reaction , definition of acute phase reaction by Medical dictionary https://medical-dictionary.thefreedictionary. ...
... ratio is associated with cardiovascular diseases and acute phase reaction but not with clinical outcome ... Elevated fibrinogen gamma ratio is associated with cardiovascular diseases and acute phase reaction but not with clinical ...
2) alpha1-microglobulin clinically proved to be a positive acute phase reactant. Serum value was ellvated postoperatively ... that have so far made it impossible to define this protein as a acute phase reactant. Futrher fundamental study is under way to ... In the process of the present study, a precise assay for SAA was developed using a latex agglutination reaction.. 4) Mechanisms ... elucidate precise mechanisms of alpha1-m reaction at the liver.. For clinical significance, total measurement of this protein ...
The aim of this study was the development of a quantitative assay that could support future studies of a panel of acute phase ... QconCAT; acute phase proteins; equine; quantotypic peptides; selected reaction monitoring; validation; veterinary proteomics; ... The aim of this study was the development of a quantitative assay that could support future studies of a panel of acute phase ... a Method for Absolute Quantification of Equine Acute Phase Proteins Using Concatenated Peptide Standards and Selected Reaction ...
Shimizu, H. ; Mitomo, K. ; Yamamoto, K. / Regulation of mouse serum amyloid A3 gene expression during acute phase reaction. In ... Shimizu, H, Mitomo, K & Yamamoto, K 1992, Regulation of mouse serum amyloid A3 gene expression during acute phase reaction., ... Regulation of mouse serum amyloid A3 gene expression during acute phase reaction. / Shimizu, H.; Mitomo, K.; Yamamoto, K. ... Regulation of mouse serum amyloid A3 gene expression during acute phase reaction. Folia histochemica et cytobiologica / Polish ...
Meloxicam as an Alternative to Alleviate Inflammatory and Acute-Phase Reactions in Beef Cattle Upon Lipopolysaccharide ... Meloxicam as an Alternative to Alleviate Inflammatory and Acute-Phase Reactions in Beef Cattle Upon Lipopolysaccharide ... Meloxicam as an Alternative to Alleviate Inflammatory and Acute-Phase Reactions in Beef Cattle Upon Lipopolysaccharide ... Meloxicam as an Alternative to Alleviate Inflammatory and Acute-Phase Reactions in Beef Cattle Upon Lipopolysaccharide ...
ACUTE-PHASE REACTION. The defense reaction of an organism to infectious or toxic agents, which helps to restrict organ damage ... FASEB J. 17, 253-255 (2003). Reveals aberrant inflammatory reactions and an elevated resistance to glucocorticoid treatment in ... Tomas, A., Futter, C. & Moss, S. E. Annexin 11 is required for midbody formation and completion of the terminal phase of ... through the cytokine-induced production of protective acute-phase proteins such as complement-reactive and serum-amyloid ...
Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions Johannes ... Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions. Theranostics ... Conclusion: Cathepsin B is actively involved in the effector phase of acute cutaneous DTHR. Thus, topically applied cathepsin B ... Compared with wild-type mice, Ctsb-/- mice exhibited an enhanced ear swelling response during acute DTHR despite a lack of ...
Acute Phase Reaction. Within three days after Zometa administration, an acute phase reaction has been reported in patients, ... Acute Phase Reaction. Within three days after Zometa administration, an acute phase reaction has been reported, with symptoms ... Injection Site Reactions. Local reactions at the infusion site, such as redness or swelling, were observed infrequently. In ... Hypersensitivity Reactions. There have been rare reports of allergic reaction with intravenous zoledronic acid including ...
Includes: indications, dosage, adverse reactions, pharmacology and more. ... Acute Phase Reaction. Within three days after Zoledronic Acid Injection administration, an acute phase reaction has been ... Acute Phase Reaction. Within three days after Zoledronic Acid Injection administration, an acute phase reaction has been ... Injection Site Reactions. Local reactions at the infusion site, such as redness or swelling, were observed infrequently. In ...
Acute-Phase Reaction. Pathologic Processes. Neurobehavioral Manifestations. Neurologic Manifestations. Nervous System Diseases ... Iatrogenic psychotic depressive reaction in hypertensive patients. Am J Psychiatry. 1971 Apr;127(10):1416-7. ...
The results of our study suggest that the acute phase response may be partly related to a yet unknown primary inflammatory ... Episodic activation of the coagulation system in unstable angina does not elicit an acute phase reaction. ... Acute-Phase Reaction, Adult, Aged, Angina, Unstable, Antithrombin III, Blood Coagulation, C-Reactive Protein, Female, Humans, ... Episodic activation of the coagulation system in unstable angina does not elicit an acute phase reaction. ...
Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis. / Schouten, W E; Grooteman, M P ... Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis. In: Nephrology, Dialysis, ... keywords = "Acute-Phase Reaction/etiology, Adult, Aged, Bacteria/growth & development, Bicarbonates/therapeutic use, C-Reactive ... Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis. Nephrology, Dialysis, ...
The overall aim of this thesis was to examine the acute phase response, as measured mainly by acute phase proteins (APP) and ... Studies on the acute phase reaction during respiratory infections in calves. Series Name/Journal:. Acta Universitatis ... Gånheim, Charina (2004). Studies on the acute phase reaction during respiratory infections in calves. Diss. (sammanfattning/ ... The acute phase response in calves experimentally infected with bovine viral diarrhoea virus and/or Mannheimia haemolytica. ...
Lipoprotein(a), Ferritin, and Albumin in Acute Phase Reaction Predicts Severity and Mortality of Acute Ischemic Stroke in North ... In our study, Lp(a) acted as an acute phase reactant while albumin acted as a negative acute phase reactant. There was no ... We studied the behavior of lipoprotein(a) [Lp(a)], ferritin, and albumin as acute phase reactants and their roles in the ... METHODS: We recruited 100 consecutive patients with acute ischemic stroke and 120 controls. Blood samples were drawn on days 1 ...
Acute-Phase Reaction , Animals , Biocompatible Materials , Blood Vessel Prosthesis , Blood Vessel Prosthesis Implantation , ... To find out which biomaterial had the best biocompatibility, we compared the acute phase reaction of common biomaterials ... Acute phase reaction of different macromolecule vascular grafts healing in rat muscle / 生物工程学报 ... Acute phase reaction of different macromolecule vascular grafts healing in rat muscle ...
Monitoring the acute phase response in non-immediate allergic drug reactions. Mayorga, Cristobalina; Pena, Rebeca R; Blanca- ... Nonimmediate hypersensitivity reactions to iodinated contrast media. Gómez, Enrique; Ariza, Adriana; Blanca-López, Natalia; ... Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: from phenotyping to genotyping. Blanca-López, Natalia; ... Hypersensitivity reactions to quinolones. Blanca-López, Natalia; Andreu, Inmaculada; Torres Jaén, Maria J. ...
Acute-Phase Reaction * Alleles * Alternative Splicing * Animals * Autoimmune Diseases / genetics * Bacteria / metabolism ...
Acute Phase Reaction Within three days after zoledronic acid injection administration, an acute phase reaction has been ... Acute Phase Reaction Within three days after zoledronic acid injection administration, an acute phase reaction has been ... Injection Site Reactions Local reactions at the infusion site, such as redness or swelling, were observed infrequently. In most ... Hypersensitivity Reactions There have been rare reports of allergic reaction with intravenous zoledronic acid including ...
Bands excised for mass spectrometric analyses are indicated (rectangles). (b) Normal human serum (NHS), acute phase reaction ... and a serum of a male individual with an acute phase reaction (CRP ca. 100 µg/ml). Normal human serum and plasma was obtained ... Depletion of CRP from CRP-containing acute phase reaction serum using the synthetic CRP ligand phosphorylcholine coupled to ... Naff, G. B. & Byers, P. H. Complement as a mediator of inflammation in acute gouty arthritis. I. Studies on the reaction ...
Paltrinieri, S. The feline acute phase reaction. Vet. J. 2008, 177, 26-35. [Google Scholar] [CrossRef] [PubMed] ... In further studies, the influence of rFeIFN-ω in the acute phase reaction was investigated [28]. In human medicine, several ... Leal, R.O.; Gil, S.; Sepúlveda, N.; McGahie, D.; Duarte, A.; Niza, M.M.R.E.; Tavares, L. Monitoring acute phase proteins in ... Treitinger, A.; Spada, C.; da Silva, L.M.; Hermes, E.M.; Amaral, J.A.; Abdalla, D.S. Lipid and acute-phase protein alterations ...
Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. ... Hypersensitivity: Acute phase reaction-like symptoms (≤8%; includes fever, influenza-like illness) ... Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or ... 1%, postmarketing, and/or case reports: Abnormal hepatic function tests, angioedema, bullous skin reaction, cough, esophageal ...
Additionally, a weak acute-phase reaction occurs. Humoral immune mediators may differ from the pre-exercise levels for up to ... Horstmann DM: Acute poliomyelitis: Relation of physical activity at the time of onset to the course of the disease. JAMA 1950; ... Es kommt zu einem diskreten Anstieg der Akut-Phase-Proteine und des Interleukin-6 im Serum (12, 19, 32, 59, 76). Eine 24 bis 48 ... Acute exercise is followed by a mobilization of white blood cells, mainly induced by increased levels of catecholamines and ...
Because chronic arthritides may present abruptly, they need to be considered in patients who present with acute polyarticular ... Viral infections, crystal-induced arthritis, and serum sickness reactions are common causes of acute, self-limited ... Acute-phase reaction, vasculitis, infection. Leukopenia. SLE, RA, Feltys syndrome, Sjögrens syndrome, human parvovirus B19 ... For example, the acute stage of Lyme disease may include polyarticular arthralgias, whereas the chronic phase may include ...
Preventive Role of Vitamin D Supplementation for Acute Phase Reaction after Bisphosphonate Infusion in Pagets Disease. ... Intravenous aminobisphosphonates (N-BPs) can induce an acute phase reaction (APR) in up to 40% to 70% of first infusions, ... Preventive Role of Vitamin D Supplementation for Acute Phase Reaction after Bisphosphonate Infusion in Pagets Disease. ( ... having any acute disease, recent modifying dose or type of drugs. The supplementation was 50,000 IU/week VD ...
  • Acute phase proteins are a class of proteins that are synthetized in the liver in response to inflammation . (statemaster.com)
  • Because the acute phase response is relatively non-specific, the value of measuring acute-phase protein concentrations is to assess the extent of inflammation reflecting momentary disease activity. (statemaster.com)
  • They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. (thefreedictionary.com)
  • The acute phase response (APR) is an early, non-specific systemic innate immune reaction to local or systemic stimulus, which helps to heal and re-establish homeostasis and minimize tissue damage when the body is affected by trauma, infection, stress, surgery, neoplasia or inflammation (GRUYS et al. (thefreelibrary.com)
  • However, data on the association between inflammation and acute diabetic foot syndrome are scarce. (diabetesjournals.org)
  • Given the surprising paucity of data on the role of systemic inflammation in diabetic foot ulcers, we evaluated the association between foot ulcers and immune status in a cross-sectional study in diabetic patients with and without foot ulcers by measuring a range of immune mediators (acute-phase proteins, cytokines, and chemokines) representing different aspects of the immune system. (diabetesjournals.org)
  • Hemantane was more effective than amantadine for relieving pain produced by inflammation owing to its pronounced anti-inflammatory activity: only hemantane decreased the amount of acetic twitches in mice that received drugs orally and was effective in the tonic phase of formalin pain in rats. (scirp.org)
  • Acute inflammation Healing Chronic Inflammation. (slideserve.com)
  • Inflammation and HealingObjectives Use a process based approach building upon previous knowledge to develop the basic pathology of acute inflammation, chronic inflammation, and healing. (slideserve.com)
  • Temporal Dynamics of Reactive Oxygen and Nitrogen Species and NF-κB Activation During Acute and Chronic T Cell-Driven Inflammation. (nih.gov)
  • It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. (abcam.com)
  • Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. (genecards.org)
  • The clinical use of acute phase proteins is as an aid to diagnosis [15]. (statemaster.com)
  • Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. (thefreedictionary.com)
  • In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. (thefreedictionary.com)
  • The acute phase response involves the production of plasma proteins as well as other metabolic, hematological, and neuroendocrine events. (thefreedictionary.com)
  • The aim of this study was the development of a quantitative assay that could support future studies of a panel of acute phase proteins (APPs) in the horse. (jpt.com)
  • In the present study, cytokine release (interleukin-6, IL-6) and subsequent production of acute phase proteins (C-reactive protein, CRP and secretory phospholipase A(2), sPLA(2)) were assessed to investigate whether the HD-induced acute phase reaction depends mainly on the type of membrane or on the sterility of the dialysate. (vumc.nl)
  • The overall aim of this thesis was to examine the acute phase response, as measured mainly by acute phase proteins (APP) and cellular response, in calves during different types of respiratory infection, and to identify potential markers useful in evaluation of their health status. (slu.se)
  • Acute phase proteins in response to Dicytocaulus viviparus infection in calves. (slu.se)
  • Acute phase proteins in cats/Proteinas de fase aguda em gatos. (thefreelibrary.com)
  • Those newly produced proteins are called acute phase proteins (APP) (TIZARD, 2013b). (thefreelibrary.com)
  • RESEARCH DESIGN AND METHODS Circulating levels of acute-phase proteins, cytokines, and chemokines were measured in diabetic patients with an ulcer ( n = 170) and without an ulcer ( n = 140). (diabetesjournals.org)
  • CONCLUSIONS We demonstrate in our cross-sectional study that acute foot ulcers and their severity are associated with a marked upregulation of acute-phase proteins, cytokines, and chemokines independently of the concomitant infection. (diabetesjournals.org)
  • Sialic acid is found in association with many acute phase proteins and in one prospective study was a powerful predictor of coronary heart disease. (bmj.com)
  • Baseline radiographic joint changes, presence of rheumatoid factor (RF), specific HLADRB1 genotypes, high disease activity, high disability scores, and high levels of acute phase proteins are examples of such factors (for reviews, see Harrison and Symmons 2 and Scott 3 ). (bmj.com)
  • The interaction between α2-M and TGF- Β may influence the production of acute-phase proteins by liver hepatocytes. (springer.com)
  • 1983. Acute phase proteins with special reference to C-reactive protein and related proteins (pentraxins) and serum amyloid A protein. (springer.com)
  • The presence of an acute-phase reaction was excluded by measurement of serum C-reactive protein. (thefreedictionary.com)
  • Regulation of mouse serum amyloid A3 gene expression during acute phase reaction. (elsevier.com)
  • There was no association between Trial of Org 10172 in Acute Stroke Treatment subtype and elevated serum levels of Lp(a), albumin, and ferritin. (althotas.com)
  • Viral infections, crystal-induced arthritis, and serum sickness reactions are common causes of acute, self-limited polyarthritis. (aafp.org)
  • In this reaction we observe several different systemic effects: fever, leukocytosis, hormone shifts-mainly cortisol and thyroxine concentrations, with a secondary catabolic state and muscle protein depletion, serum depletion of iron and zinc, among others (CERON et al. (thefreelibrary.com)
  • No acute-phase serum or tissue samples for viral isolation or polymerase chain reaction (PCR) were obtained. (cdc.gov)
  • Convalescent-phase serum samples collected 351 days after vaccination demonstrated a YF-neutralizing antibody titer of 1:640. (cdc.gov)
  • We report on a patient with TBE and HGE in whom infection with A. phagocytophilum was demonstrated by polymerase chain reaction (PCR) and seroconversion, and TBE virus infection was established by the presence of immunoglobin (Ig)M and IgG antibodies to TBE virus in serum. (cdc.gov)
  • CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. (fishersci.com)
  • stimulating the acute phase response, leading to an increase in C-reactive protein and a number of other mediators. (statemaster.com)
  • Another acute-phase reaction , elevated levels of C-reactive protein, may occur. (thefreedictionary.com)
  • Since its molecular weight was low, it is easily cleared from kidney, that have so far made it impossible to define this protein as a acute phase reactant. (nii.ac.jp)
  • We addressed the question of whether SRC-1 is crucial for IL-6- and STAT3-mediated physiological responses such as myeloma cell survival and acute-phase protein induction. (biochemj.org)
  • C Reactive protein is the major acute phase protein in humans. (bmj.com)
  • An allergy is an adverse reaction to a protein in our environment, such as those found on pets, and in pollen or nuts. (amazonaws.com)
  • The major regulator of acute-phase protein synthesis in man and rat. (springer.com)
  • 1982. C-reactive protein and the acute phase response. (springer.com)
  • This gene encodes a key acute phase plasma protein. (genecards.org)
  • TNFα is a member of a group of other cytokines that all stimulate the acute phase reaction . (statemaster.com)
  • NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. (abcam.com)
  • As the acute phase response is stimulated by diverse cytokines that activate either NF-κB or STAT3, we hypothesized that it could be eliminated by hepatocyte-specific interruption of both transcription factors. (jci.org)
  • More than 10 % of observed acute phase reactant values (for C3, haptoglobin and ferritin) were also below the low end of the reference interval. (nih.gov)
  • 2) alpha1-microglobulin clinically proved to be a positive acute phase reactant. (nii.ac.jp)
  • In our study, Lp(a) acted as an acute phase reactant while albumin acted as a negative acute phase reactant. (althotas.com)
  • Episodic activation of the coagulation system in unstable angina does not elicit an acute phase reaction. (ox.ac.uk)
  • Acute strenuous exercise did not elicit an acute phase reaction. (biomedsearch.com)
  • Here, we uncovered the role of cysteine-type cathepsins in the effector phase of T cell-driven cutaneous delayed-type hypersensitivity reactions (DTHR) and the implication of this role on therapeutic cathepsin B-specific inhibition. (thno.org)
  • Futrher fundamental study is under way to elucidate precise mechanisms of alpha1-m reaction at the liver. (nii.ac.jp)
  • The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. (jci.org)
  • Thus, we conclude that RelA and STAT3 are essential for stress-induced transcriptional remodeling in the liver and the subsequent activation of the acute phase response, whose functional role includes compartmentalization of local infection. (jci.org)
  • Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the United States. (jci.org)
  • For swift and precise detection of bacteremia, an in vitro study using a polymerase chain reaction (PCR) for bacterial DNA seems promising. (aappublications.org)
  • We report a patient with febrile illness and epidemiologic and clinical findings consistent with human granulocytic ehrlichiosis and tickborne encephalitis, in whom infection with Anaplasma phagocytophilum was demonstrated by polymerase chain reaction and seroconversion. (cdc.gov)
  • Polymerase chain reaction amplification of Anaplasma phagocytophilum DNA from the patient's acute-phase blood sample. (cdc.gov)
  • Nine days after vaccination, he was hospitalized with a fulminant illness characterized by fever of 101.6º F (38.7º C) and acute hepatic and renal failure ( Table ). (cdc.gov)
  • Hepatic acute phase reaction in vivo and in vitro . (springer.com)
  • Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). (rxlist.com)
  • Height of fever, duration of fever, acute illness observation score, absolute band count, and white blood cell count were all much less predictive of bacteremia than either IL-6 or absolute neutrophil count (ANC). (aappublications.org)
  • Samples were analysed for 20 cellular and non-cellular biomarkers which included 11 immunological and 9 acute phase reactants. (nih.gov)
  • Routine exercise appears to lower resting numbers of a variety of immune cell-types as well as the concentration of several classical acute phase reactants. (nih.gov)
  • We studied the behavior of lipoprotein(a) [Lp(a)], ferritin, and albumin as acute phase reactants and their roles in the severity and mortality of stroke. (althotas.com)
  • Elevated fibrinogen in an acute phase reaction prolongs the reptilase time but typically not the thrombin time. (medscape.com)
  • In the horizontal aspect, he listed 6 stages of pathological development, three "Humoral" phases and three "Cellular" phases. (townsendletter.com)
  • In the early "humoral" phases of pathology, the principle of regulation is excretion of pathogens and all harmful elements. (townsendletter.com)
  • Moreover, this interruption of the acute phase response increased mortality and exacerbated bacterial dissemination during pneumonia, possibly as a result of acute humoral enhancement of macrophage opsonophagocytosis, which was impaired in the mutant mice. (jci.org)
  • COX-2 induction is readily demonstrable in ECs and/or PVCs after such challenges, and its expression correlates with several acute phase endpoints across a range of experimental conditions. (jneurosci.org)
  • Wild-type, cathepsin B-deficient (Ctsb -/- ) and cathepsin Z-deficient (Ctsz -/- ) mice were sensitized with 2,4,6-trinitrochlorobenzene (TNCB) on the abdomen and challenged with TNCB on the right ear to induce acute and chronic cutaneous DTHR. (thno.org)
  • Acute exercise does not induce an acute phase response (APR) in Standardbred trotters. (biomedsearch.com)
  • This information would be useful for clinicians interpreting blood tests assessing inflammatory, immune and acute phase responses. (nih.gov)
  • IL-6 plays a role in host defense, acute phase reactions, immune responses, and hematopoiesis. (biolegend.com)
  • However, the time required for de novo enzyme synthesis poses stern questions as to the relevance of prostanoids generated in this manner in initiating rapid acute phase responses. (jneurosci.org)
  • These responses are collectively termed the acute-phase reaction (APR). (uthsc.edu)
  • In the realm of immunology, substances that cause immune responses or allergic reactions are known as antigens. (amazonaws.com)
  • Here, we report that the elimination in mice of both NF-κB p65 (RelA) and STAT3, but neither alone, abrogated all acute phase responses measured. (jci.org)
  • Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. (rxlist.com)
  • To report SUSPECTED ADVERSE REACTIONS, contact Avet Pharmaceuticals Inc. at 1-866-901-DRUG (3784) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . (nih.gov)
  • The aim of this review is to explore the risk of adverse drug reactions and drug-drug interactions with treatments for postmenopausal osteoporosis. (springer.com)
  • We reviewed evidence for adverse reactions from regulatory documents, randomized controlled trials, pharmacovigilance surveys, and case series. (springer.com)
  • The solidity of the evidence base depends on the frequency of the reaction, and causality is not always easy to establish for the very rare adverse reactions. (springer.com)
  • Osteoporosis treatments are generally safe and well tolerated, though they are associated with a few very rare serious adverse reactions. (springer.com)
  • The incidence of serious adverse reactions was 6.5% in the Atelvia 35 mg once-a-week group and 7.2% in the risedronate sodium immediate-release 5 mg daily group. (rxlist.com)
  • The percentage of patients who withdrew from the study due to adverse reactions was 9.1% in the Atelvia 35 mg once-a-week group and 8.1% in the risedronate sodium immediate-release 5 mg daily group. (rxlist.com)
  • Although the common adverse reactions generally disappear within 72 h, or in rare cases, last 7 to 10 days without recurrence, they have serious impacts on the aging population, especially those with underlying diseases. (scirp.org)
  • Thus, the patients who are afraid of any adverse reactions or have suffered from any side effects during the first administration may show poor compliance with the second dose and refuse the clinical application of zoledronic acid. (scirp.org)
  • 1986. Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hematoma cells in vitro . (springer.com)
  • Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that has been implicated in the pathogenesis of several postoperative complications. (mendeley.com)
  • Lipoprotein(a), Ferritin, and Albumin in Acute Phase Reaction Predicts Severity and Mortality of Acute Ischemic Stroke in North Indian Patients. (althotas.com)
  • Acute gout attacks are treated with nonsteroidal anti-inflammatory drugs, colchicine or glucocorticoids. (nature.com)
  • The acute phase response is part of the body's reaction to injury or infection. (bmj.com)
  • The immune system, which can be further divided into innate or adaptive sections, is the body's key mechanism of defense against infection, but also the system responsible for pathological allergic reactions to harmless substances. (amazonaws.com)
  • 1985. Acute Phase Response to Injury and Infection , Elsevier, Amsterdam. (springer.com)
  • The acute phase response in calves experimentally infected with bovine viral diarrhoea virus and/or Mannheimia haemolytica. (slu.se)
  • The observed acute increase in hemoglobin levels and decreases in haptoglobin and iron levels may have been caused by exercise-induced hemolysis, which indicates that horses might experience a condition similar to athlete's anemia in humans. (biomedsearch.com)
  • Therefore, the type of membrane, rather than the bacterial quality of the dialysate, seems to be responsible for the induction of the acute phase response during clinical bicarbonate HD. (vumc.nl)
  • The pathogenesis and clinical implications of the hematological and blood-biochemical changes elicited by acute exercise in Standardbred trotters in the present study warrant further investigation. (biomedsearch.com)
  • METHODS: We recruited 100 consecutive patients with acute ischemic stroke and 120 controls. (althotas.com)
  • Because chronic arthritides may present abruptly, they need to be considered in patients who present with acute polyarticular joint pain. (aafp.org)
  • Data from Europe are limited to the reports on coinfections with TBE virus and Borrelia burgdorferi sensu lato (s.l.) in patients with acute meningitis ( 3 - 7 ). (cdc.gov)
  • Underdiagnosis of WD is highly likely, especially during the asymptomatic phase and in patients with atypical presentations. (thefreelibrary.com)
  • Physicians should therefore be alert to any signs or symptoms signaling a possible esophageal reaction and patients should be instructed to discontinue ACTONEL and seek medical attention if they develop dysphagia, odynophagia, retrosternal pain or new or worsening heartburn. (bioportfolio.com)
  • MethodsForty patients with respiratory and/or neurological symptoms following acute fire smoke inhalation had pulmonary function tests and blood gas analyses performed on admission, at discharge, and after 3 months. (uio.no)
  • It turns out that IgE-associated allergic reactions (type-1) and delayed hypersensitivity reactions (type-4) are examples of two types of immune response that are directed by two distinct subtypes of helper T lymphocyte (Th cells). (amazonaws.com)
  • Evidence of acute phase reaction in asymptomatic dogs naturally infected with Babesia canis. (physiciansweekly.com)
  • After transplanted the materials of dacron , polyterafluoroethylene (e- PTFE ), polyurethane (PU), SF-PU(11) in rat muscle for one week, we studied the influence of different biomaterials on the histocompatibility by using rat acute toxicity test , test of local reaction in muscle , tissue section staining , WBC and PLT count. (bvsalud.org)
  • Allergy is classically defined as an exaggerated, pathological, specific immunologic reaction to foreign (exogenous) substances. (amazonaws.com)
  • Golden D. Patterns of anaphylaxis: Acute and late phase features of allergic reactions. (uptodate.com)
  • Allergic reactions do not happen the first time you come into contact with an allergen, but at a later point of contact. (amazonaws.com)
  • Although thought to be involved in immune defense, the net biological effect of the acute phase response remains unknown. (jci.org)
  • Noninvasive in vivo optical imaging revealed strong cysteine-type cathepsin activity in inflamed ears and draining lymph nodes in acute and chronic cutaneous DTHR. (thno.org)
  • BACKGROUND: In chronic haemodialysis (HD), morbidity may result from repetitive induction of the acute phase response, caused by a bioincompatible dialysis membrane and/or contaminated dialysate. (vumc.nl)
  • Type III reactions result when the antigen- antibody complexes (immune complexes) become deposited on the walls of the small blood vessels. (amazonaws.com)
  • Functional involvement of COX-1 is indicated by the observation that central, but not systemic, pretreatment with the selective COX-1 inhibitor SC-560 attenuated the early phase of LPS-induced increases in adrenocorticotropin and corticosterone secretion. (jneurosci.org)
  • Enzymatic defenses: Phase I and II biotransformation mechanisms. (unige.it)
  • The acute phase reaction: mechanisms, consequences and significance. (unige.it)
  • Atypical patterns of anaphylaxis, the incidence of atypical patterns of reactions, and proposed risk factors for these reactions will be reviewed here. (uptodate.com)
  • The other biomaterials had slight local inflammatory reaction. (bvsalud.org)
  • Emphasis is given to the central role of transcription factor NF-kB in the complex mechanism of the inflammatory reaction and to the effects of compounds such as heparin and glycosaminoglycans, phosphodiesterase inhibitors and protease inhibitors whose role as anti-inflammatory agent has only recently been recognized. (mendeley.com)
  • Movement from Phase One toward Phase Six maps the decline of the body's structural and functional integrity. (townsendletter.com)
  • Stroke was classified using Trial of Org 10172 in Acute Stroke Treatment classification. (althotas.com)