Mastitis, Bovine: INFLAMMATION of the UDDER in cows.Mastitis: INFLAMMATION of the BREAST, or MAMMARY GLAND.Milk: The white liquid secreted by the mammary glands. It contains proteins, sugar, lipids, vitamins, and minerals.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.DairyingAcute-Phase Proteins: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Serum Amyloid A Protein: An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.Haptoglobins: Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.Streptococcus: A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Respiration, Artificial: Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Hospital Mortality: A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.Ventilator Weaning: Techniques for effecting the transition of the respiratory-failure patient from mechanical ventilation to spontaneous ventilation, while meeting the criteria that tidal volume be above a given threshold (greater than 5 ml/kg), respiratory frequency be below a given count (less than 30 breaths/min), and oxygen partial pressure be above a given threshold (PaO2 greater than 50mm Hg). Weaning studies focus on finding methods to monitor and predict the outcome of mechanical ventilator weaning as well as finding ventilatory support techniques which will facilitate successful weaning. Present methods include intermittent mandatory ventilation, intermittent positive pressure ventilation, and mandatory minute volume ventilation.Prealbumin: A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.Lung Diseases, Obstructive: Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Orosomucoidalpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Myocardial Reperfusion Injury: Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Acute-Phase Reaction: An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Cell Line, Tumor: A cell line derived from cultured tumor cells.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.p38 Mitogen-Activated Protein Kinases: A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
(1/1561) Predominant immunoglobulin A response to phase II antigen of Coxiella burnetii in acute Q fever.

Diagnosis of acute Q fever is usually confirmed by serology, on the basis of anti-phase II antigen immunoglobulin M (IgM) titers of >/=1:50 and IgG titers of >/=1:200. Phase I antibodies, especially IgG and IgA, are predominant in chronic forms of the disease. However, between January 1982 and June 1998, we observed anti-phase II antigen IgA titers of >/=1:200 as the sole or main antibody response in 10 of 1,034 (0.96%) patients with acute Q fever for whom information was available. In order to determine whether specific epidemiological or clinical factors were associated with these serological profiles, we conducted a retrospective case-control study that included completion of a standardized questionnaire, which was given to 40 matched controls who also suffered from acute Q fever. The mean age of patients with elevated phase II IgA titers was significantly higher than that usually observed for patients with acute Q fever (P = 0.026); the patients were also more likely than controls to live in rural areas (P = 0.026) and to have increased levels of transaminase in blood (P = 0.03). Elevated IgA titers are usually associated with chronic Q fever and are directed mainly at phase I antigens. Although the significance of our findings is unexplained, we herein emphasize the fact that IgA antibodies are not specific for chronic forms of Q fever and that they may occasionally be observed in patients with acute disease. Moreover, as such antibody profiles may not be determined by most laboratories, which test only for total antibody titers to phase I and II antigens, the three isotype-specific Ig titers should be determined as the first step in diagnosing Q fever.  (+info)

(2/1561) The STAT3-independent signaling pathway by glycoprotein 130 in hepatic cells.

Interleukin (IL)-6 is a major regulator of hepatic acute-phase plasma protein (APP) genes. The membrane-proximal 133-amino acid cytoplasmic domain of glycoprotein (gp) 130, containing one copy of the Box3 motif, is sufficient to transmit a productive signal to endogenous APP genes in rat hepatoma H-35 cells. In contrast, a mutant gp130 domain lacking the Box3 motif activates Janus kinases to a normal level but fails to activate signal transducer and activator of transcription 3 and to up-regulate a number of APP genes, including thiostatin, fibrinogen, hemopexin, and haptoglobin. However, in the absence of Box3, gp130 still stimulates the expression of alpha2-macroglobulin and synergizes with IL-1 to up-regulate alpha1-acid glycoprotein. The Box3 motif is not required for activation of the SH2-containing protein tyrosine phosphatase 2 or the mitogen-activated protein kinase (MAPK), nor is the immediate induction of egr-1 and junB significantly altered. Surprisingly, gp130 without any functional Box3 stimulates prolonged activation of MAPK, leading to an extended period of up-regulation of egr-1 and to an extracellularly regulated kinase-mediated reduction in the IL-6-stimulated production of thiostatin. IL-6 reduces proliferation of H-35 cells through signaling by the Box3. In addition, cells expressing Box3-deficient gp130 showed distinct morphologic changes upon receptor activation. Taken together, these results indicate that Box3-derived and Box3-independent signals cooperate in the control of hepatic APP genes and that Box3 may be involved in the modulation of MAPK activity in gp130 signaling.  (+info)

(3/1561) Lipopolysaccharide stimulates HepG2 human hepatoma cells in the presence of lipopolysaccharide-binding protein via CD14.

Lipopolysaccharide (LPS)-binding protein (LBP), an opsonin for activation of macrophages by bacterial LPS, is synthesized in hepatocytes and is known to be an acute phase protein. Recently, cytokine-induced production of LBP was reported to increase 10-fold in hepatocytes isolated from LPS-treated rats, compared with those from normal rats. However, the mechanism by which the LPS treatment enhances the effect of cytokines remains to be clarified. In the present study, we examined whether LPS alone or an LPS/LBP complex directly stimulates the hepatocytes, leading to acceleration of the cytokine-induced LBP production. HepG2 cells (a human hepatoma cell line) were shown to express CD14, a glycosylphosphatidylinositol-anchored LPS receptor, by both RT/PCR and flow cytometric analyses. An LPS/LBP complex was an effective stimulator for LBP and CD14 production in HepG2 cells, but stimulation of the cells with either LPS or LBP alone did not significantly accelerate the production of these proteins. The findings were confirmed by semiquantitative RT/PCR analysis of mRNA levels of LBP and CD14 in HepG2 cells after stimulation with LPS alone and an LPS/LBP complex. In addition, two monoclonal antibodies (mAbs) to CD14 (3C10 and MEM-18) inhibited LPS/LBP-induced cellular responses of HepG2 cells. Furthermore, prestimulation of HepG2 cells with LPS/LBP augmented cytokine-induced production and gene expression of LBP and CD14. All these findings suggest that an LPS/LBP complex, but not free LPS, stimulates HepG2 cells via CD14 leading to increased basal and cytokine-induced LBP and CD14 production.  (+info)

(4/1561) Heme and acute inflammation role in vivo of heme in the hepatic expression of positive acute-phase reactants in rats.

Acute-phase protein synthesis in the liver during inflammation is regulated via cytokines and glucocorticoids. Using quantitative reverse transcription (RT)-PCR analysis and immunoassay, we explored, in the rat, the response of the acute-phase protein, alpha-2 macroglobulin (A2M), after systemic inflammation induced by lipopolysaccharide (LPS) or localized inflammation induced by turpentine oil (TO). The results indicate that synthesis of A2M is higher following TO-induced inflammation than LPS-induced inflammation and is not correlated with interleukin (IL)-6 or glucocorticoid levels. We studied the putative role of heme in this differential A2M expression following localized vs. systemic inflammation; addition of heme during LPS-induced inflammation can boost the expression of A2M, whereas blocking heme synthesis (by succinyl acetone) or enhancing its consumption in parallel biosynthetic pathways (cytochrome P450 induction by phenobarbital) decreases A2M expression. This decrease was abolished by exogenous heme supplementation. Finally, we demonstrate that heme supplementation is also able to increase the A2M response in female rats to a level similar to that in male rats providing a new insight into the puzzling sexual dimorphism observed previously during localized inflammation. We propose that heme should be considered a new regulatory element in controlling liver A2M expression during inflammation.  (+info)

(5/1561) Endotoxin interactions with lipopolysaccharide-responsive cells.

Recent work has identified two proteins that work together to enable many cell types to respond to endotoxin. These two proteins, lipopolysaccharide (LPS) binding protein (LBP) and CD14, also participate in cellular internalization of endotoxin, which may occur independently of cellular activation. Current work with antibodies to LBP and CD14 as well as "knockout" mice in the context of LPS-initiated endotoxic shock suggests that inhibition of this pathway could be therapeutically useful. These observations point to the need to identify new molecules that mediate LPS-initiated transmembrane signaling and internalization of LPS-protein complexes.  (+info)

(6/1561) Lipopolysaccharide-coated erythrocytes activate human neutrophils via CD14 while subsequent binding is through CD11b/CD18.

Interaction of LPS with monocytes and neutrophils is known to occur via CD14 and is strongly enhanced by LPS-binding protein (LBP). Integrins as well as CD14 play a role in the interaction of erythrocytes (E) coated with LPS or whole Gram-negative bacteria with phagocytes. We reasoned that the density of LPS on a particle is an important determinant in these interactions. Therefore, E were coated with different concentrations of LPS (ELPS). The binding of these ELPS to neutrophils was evaluated by flow cytometry. Simultaneously, we measured fMLP receptor expression to evaluate neutrophil activation. ELPS only bound to neutrophils in the presence of LBP. Blocking CD14 inhibited both activation and binding, whereas blocking complement (C) receptor 3 (CR3) inhibited binding but not activation. TNF activation restored ELPS binding in CD14-blocked cells but not in cells in which CR3 was blocked. Salmonella minnesota did bind to neutrophils independent of CR3 or CD14. The addition of LBP enhanced binding twofold, and this surplus was dependent upon CD14 but not on CR3. We conclude that ELPS interact with neutrophils via CD14, initially giving rise to cell activation; subsequently, binding is solely mediated by activated CR3.  (+info)

(7/1561) Membrane-anchored forms of lipopolysaccharide (LPS)-binding protein do not mediate cellular responses to LPS independently of CD14.

Inflammatory responses of myeloid cells to LPS are mediated through CD14, a glycosylphosphatidylinositol-anchored receptor that binds LPS. Since CD14 does not traverse the plasma membrane and alternatively anchored forms of CD14 still enable LPS-induced cellular activation, the precise role of CD14 in mediating these responses remains unknown. To address this, we created a transmembrane and a glycosylphosphatidylinositol-anchored form of LPS-binding protein (LBP), a component of serum that binds and transfers LPS to other molecules. Stably transfected Chinese hamster ovary (CHO) fibroblast and U373 astrocytoma cell lines expressing membrane-anchored LBP (mLBP), as well as separate CHO and U373 cell lines expressing membrane CD14 (mCD14), were subsequently generated. Under serum-free conditions, CHO and U373 cells expressing mCD14 responded to as little as 0.1 ng/ml of LPS, as measured by NF-kappaB activation as well as ICAM and IL-6 production. Conversely, the vector control and mLBP-expressing cell lines did not respond under serum-free conditions even in the presence of more than 100 ng/ml of LPS. All the cell lines exhibited responses to less than 1 ng/ml of LPS in the presence of the soluble form of CD14, demonstrating that they are still capable of LPS-induced activation. Taken together, these results demonstrate that mLBP, a protein that brings LPS to the cell surface, does not mediate cellular responses to LPS independently of CD14. These findings suggest that CD14 performs a more specific role in mediating responses to LPS than that of simply bringing LPS to the cell surface.  (+info)

(8/1561) Blood concentrations of pancreatitis associated protein in neonates: relevance to neonatal screening for cystic fibrosis.

AIM: To determine whether pancreatitis associated protein (PAP) is a marker for cystic fibrosis which could be used in neonatal screening for the disease. METHODS: PAP was assayed on screening cards from 202,807 neonates. Babies with PAP > or = 15 ng/ml, or > or = 11.5 ng/ml and immunoreactive trypsinogen (IRT) > or = 700 ng/ml were recalled for clinical examination, sweat testing, and cystic fibrosis transmembrane regulator (CFTR) gene analysis. RESULTS: Median PAP value was 2.8 ng/ml. Forty four cases of cystic fibrosis were recorded. Recalled neonates (n = 398) included only 11 carriers. A receiver operating characteristic curve analysis showed that PAP above 8.0 ng/ml would select 0.76% of babies, including all those with cystic fibrosis, except for one with meconium ileus and two with mild CFTR mutations. Screening 27,146 babies with both PAP and IRT showed that only 0.12% had PAP > 8.0 ng/ml and IRT > 700 ng/ml, including all cases of cystic fibrosis. CONCLUSION: PAP is increased in most neonates with cystic fibrosis and could be used for CF screening. Its combination with IRT looks promising.  (+info)

*  Alpha-1 antitrypsin
Kushner, Mackiewicz A (1993). The acute phase response: an overview. Acute-phase glycoproteins: molecular biology, biochemistry ... The term alpha-1 refers to the protein's behavior on protein electrophoresis. On electrophoresis, the protein component of the ... In the acute phase reaction, a further elevation is required to "limit" the damage caused by activated neutrophil granulocytes ... which could confer this protein particular protein-cell recognition properties. The single cysteine residue of A1AT in position ...
*  Serum amyloid A1
... (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly ... Zimlichman S, Danon A, Nathan I, Mozes G, Shainkin-Kestenbaum R (Aug 1990). "Serum amyloid A, an acute phase protein, inhibits ... "Entrez Gene: SAA1 serum amyloid A1". Gabay C, Kushner I (Feb 1999). "Acute-phase proteins and other systemic responses to ... Malle E, Sodin-Semrl S, Kovacevic A (Jan 2009). "Serum amyloid A: an acute-phase protein involved in tumour pathogenesis". ...
*  Haptoglobin
It is theorized that, because of this, haptoglobin has evolved into an acute-phase protein. HP has a protective influence on ... As haptoglobin is indeed an acute-phase protein, any inflammatory process (infection, extreme stress, burns, major crush injury ... The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. Hp exists in ... For this reason, it is often referred to as the suicide protein. Haptoglobin is produced mostly by hepatic cells but also by ...
*  Acute-phase protein
This response is called the acute-phase reaction (also called acute-phase response). The terms acute-phase protein and acute- ... Acute-phase proteins (APPs) are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or ... Increased acute-phase proteins from the liver may also contribute to the promotion of sepsis. Positive acute-phase proteins ... Inflammation and Acute Phase Proteins in Haemostasis. Acute Phase Proteins [Internet]. 2013 [cited 15 October 2015];. Available ...
*  Cardiac marker
... s are therefore not useful in diagnosing a myocardial infarction in the acute phase. The clinical presentation ... and C-reactive protein. Elevated levels of suPAR are associated with increased risk of systemic inflammatory response syndrome ... Many acute cardiac marker IVD products are targeted at nontraditional markets, e.g., the hospital ER instead of traditional ... NISSEN NI, RANLOV P, WEIS-FOGH J (July 1965). "EVALUATION OF FOUR DIFFERENT SERUM ENZYMES IN THE DIAGNOSIS OF ACUTE MYOCARDIAL ...
*  SAA2
1990). "Serum amyloid A, an acute phase protein, inhibits platelet activation". J. Lab. Clin. Med. 116 (2): 180-6. PMID 1697614 ... Ancsin JB, Kisilevsky R (1997). "Characterization of high affinity binding between laminin and the acute-phase protein, serum ... an acute-phase serum amyloid A protein gene (SAA2)". Genomics. 16 (2): 447-54. doi:10.1006/geno.1993.1209. PMID 7686132. " ... "Entrez Gene: SAA2 Serum amyloid A2". Betts JC, Edbrooke MR, Thakker RV, Woo P (1991). "The human acute-phase serum amyloid A ...
*  Reperfusion injury
Zhao JJ (Jan 2014). "Protection of mesenchymal stem cells on acute kidney injury". Mol Med Rep. 9 (1): 91-96. doi:10.3892/mmr. ... Cyclosporin has been confirmed in studies to inhibit the actions of cyclophilin D, a protein which is induced by excessive ... To that end, in 2011 the researchers involved in the original 2008 NEJM study initiated a phase III clinical study of ... Ciclosporin is currently in a phase II/III (adaptive) clinical study in Europe to determine its ability to ameliorate neuronal ...
*  Transferrin
... is an acute phase protein and is therefore seen to decrease in inflammation, cancers, and certain diseases. ... permanent dead link] Jain S, Gautam V, Naseem S (Jan 2011). "Acute-phase proteins: As diagnostic tool". Journal of Pharmacy & ... "Reference distributions for the negative acute-phase serum proteins, albumin, transferrin and transthyretin: a practical, ... "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". The Journal of Clinical Endocrinology and ...
*  Reference ranges for blood tests
Acute phase proteins are markers of inflammation. Autoantibodies are usually absent or very low, so instead of being given in ... "C-reactive protein". GPnotebook. 2730 Serum C-Reactive Protein values in Diabetics with Periodontal Disease A.R. Choudhury, and ... Derived from mass values using molar mass of 314.46 g/mol Bhattacharya Sudhindra Mohan (July/August 2005) Mid-luteal phase ... Included here are also related binding proteins, like ferritin and transferrin for iron, and ceruloplasmin for copper. If ...
*  Oncostatin M
OSM can regulate the expression of acute phase proteins. OSM regulates the expression of various protease and protease ... Of the proteins recruited to type I cytokine receptors STAT proteins remain the best studied. Homodimerisation of gp130 has ... "Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal ... effect on the acute phase reaction". Z Ernahrungswiss. 37 Suppl 1: 43-9. PMID 9558728. Schieven GL, Kallestad JC, Brown TJ, ...
*  Adiposopathy
... acute phase proteins / reactants such as C-reactive protein; (3) adipokines of the alternative complement system; (4) ... such as C-Reactive protein, interleukin-6, and tumor necrosis alpha) with weight gain Abnormalities in lipoprotein particle ...
*  Ferritin
As ferritin is also an acute-phase reactant, it is often elevated in the course of disease. A normal C-reactive protein can be ... Ferritin is a globular protein complex consisting of 24 protein subunits forming a nanocage with multiple metal-protein ... this implies that it is an acute phase protein. Mitochondrial ferritin has many roles pertaining to molecular function. It ... Ong DS, Wang L, Zhu Y, Ho B, Ding JL (2005). "The response of ferritin to LPS and acute phase of Pseudomonas infection". ...
*  Ciliary neurotrophic factor
1993). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. 314 (3): 280-4. doi: ... "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. 314 (3): 280-4. doi:10.1016/0014 ... Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. The protein encoded by this gene is a ... Phase III clinical trials for the drug against obesity were conducted in 2003 by Axokine's maker, Regeneron, demonstrating a ...
*  Interleukin-6 receptor
Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein ... Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (1992). "Ciliary neurotrophic factor induces acute-phase protein ... PTH-related protein receptor gene". Endocrinology. 140 (2): 925-32. doi:10.1210/en.140.2.925. PMID 9927325. IL6R protein, human ... The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer ...
*  Innate immune system
Many acute-phase proteins of inflammation are involved in the coagulation system. Also increased levels of lactoferrin and ... This leads to antiviral protein production, such as protein kinase R, which inhibits viral protein synthesis, or the 2′,5′- ... "Resistance" (R) proteins, encoded by R genes, are widely present in plants and detect pathogens. These proteins contain domains ... The cascade is composed of many plasma proteins, synthesized in the liver, primarily by hepatocytes. The proteins work together ...
*  Coagulation
Many acute-phase proteins of inflammation are involved in the coagulation system. In addition, pathogenic bacteria may secrete ... Thrombomodulin binds these proteins in such a way that it activates Protein C. The activated form, along with protein S and a ... as well as Protein S, Protein C and Protein Z. In adding the gamma-carboxyl group to glutamate residues on the immature ... Protein C is activated in a sequence that starts with Protein C and thrombin binding to a cell surface protein thrombomodulin. ...
*  Lymphoma in animals
This test utilises the acute phase proteins (C-Reactive Protein and Haptoglobin). In combination with basic clinical symptoms, ... Serum thymadine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease. K A ... Hypercalcemia in these cases is caused by secretion of parathyroid hormone-related protein. Multicentric lymphoma presents as ...
*  PTX3
"Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins". J. Immunol. 153 (8): 3700-7. PMID ... PTX3 behaves as an acute phase response protein, as the blood levels of PTX3, low in normal conditions (about 25 ng/mL in the ... Pentraxin-related protein PTX3 also known as TNF-inducible gene 14 protein (TSG-14) is a protein that in humans is encoded by ... is a novel member of the pentaxin family of acute phase proteins". J. Immunol. 150 (5): 1804-12. PMID 7679696. Alles VV, ...
*  Rivalta test
Since those are Acute-phase proteins, a positive Rivalta's test may be suggestive of inflammation. To perform this test, a ... Using a pH 4.0 acetic acid solution, 8 types of proteins were identified in Rivalta reaction-positive turbid precipitates: C- ... Not only the high protein content, but high concentrations of fibrinogen and inflammatory mediators lead to a positive reaction ... reactive protein (CRP), Alpha 1-antitrypsin (alpha1-AT), Orosomucoid ((Alpha-1-acid glycoprotein or AGP)), haptoglobin (Hp), ...
*  Classical complement pathway
These globular regions of C1q can also bind to bacterial and viral surface proteins, apoptotic cells, and acute phase proteins ... The classical complement pathway can also be activated by apoptotic cells, necrotic cells, and acute phase proteins. The ... Following activation, a series of proteins are recruited to generate C3 convertase (C4bC2b), which cleaves the C3 protein. The ... In addition, the C5 convertase initiates the terminal phase of the complement system, leading to the assembly of the membrane ...
*  Erythrocyte sedimentation rate
C-reactive protein is an acute phase protein produced by the liver during an inflammatory reaction. Since C-reactive protein ... Jens Georg Hansen; Henrik Schmidt; Jorn Rosborg; Elisabeth Lund (22 July 1995). "Predicting acute maxillary sinusitis in a ... low plasma protein (due to liver or kidney disease) and congestive heart failure. The basal ESR is slightly higher in females. ... both tests for ESR and CRP were found to be independently associated with a diagnosis of acute maxillary sinusitis so in some ...
*  HAMP
2003). "Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein". Blood. 101 (7): 2461-3. doi ... Hepcidin is a protein that in humans is encoded by the HAMP gene. The product encoded by this gene is involved in the ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload". J Biol Chem. 276 ...
*  CPN1
2000). "Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not". J. Immunol. 165 (2 ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. ...
*  Laminin, alpha 1
Ancsin JB, Kisilevsky R (1997). "Characterization of high affinity binding between laminin and the acute-phase protein, serum ... "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Arch. Immunol ... Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin, alpha 1 has been shown to interact ... 1994). "Dystroglycan is a binding protein of laminin and merosin in peripheral nerve". FEBS Lett. 352 (1): 49-53. doi:10.1016/ ...
*  Aleksander Koj
In 1996 he received Prize of the Foundation for Polish Science for his researches on acute-phase protein. In 1976 he was ...
*  Norovirus
... a major structural protein (VP1) of about 58~60 kDa and a minor capsid protein (VP2). The most variable region of the viral ... Ligocyte announced in 2007 that it was working on a vaccine and had started phase 1 trials. The company has since been taken ... The norovirus was originally named the "Norwalk agent" after Norwalk, Ohio, in the United States, where an outbreak of acute ... The two vaccines rely on using a virus-like particle that is made of the norovirus capsid proteins in order to mimic the ...
*  Hemopexin
... , an acute phase protein, can downregulate the angiotensin (ang) II type 1 receptor (AT1-R) in vitro. Hx-dependent ... Hp and Hx, both are acute-phase proteins, induced during infection and inflammatory states to minimize tissue injury and ... Hemopexin (or haemopexin; HPX), also known as beta-1B-glycoprotein is a protein that in humans is encoded by the HPX gene and ... Its function is scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin and thus protects the ...
Acute-phase protein - Wikipedia  Acute-phase protein - Wikipedia
This response is called the acute-phase reaction (also called acute-phase response). The terms acute-phase protein and acute- ... Acute-phase proteins (APPs) are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or ... Increased acute-phase proteins from the liver may also contribute to the promotion of sepsis. Positive acute-phase proteins ... Inflammation and Acute Phase Proteins in Haemostasis. Acute Phase Proteins [Internet]. 2013 [cited 15 October 2015];. Available ...
more infohttps://en.wikipedia.org/wiki/Acute-phase_protein
British Library EThOS: Acute phase proteins, proteomics and metabolomics in the diagnosis of bovine mastitis  British Library EThOS: Acute phase proteins, proteomics and metabolomics in the diagnosis of bovine mastitis
Three acute phase proteins (APP); haptoglobin (Hp), mammary associated serum amyloid A3 (M-SAA3) and C-reactive protein (CRP) ... Acute phase proteins, proteomics and metabolomics in the diagnosis of bovine mastitis ...
more infohttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650343
Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort...  Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort...
CRP is a classical acute-phase protein displaying rapid and pronounced rise of its plasma concentration in response to acute ... As CRP is one of several acute-phase proteins, whose concentrations increase during acute or chronic inflammation, other ... factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein ... Pepys MB, Hirschfield GM: C-reactive protein: a critical update. J Clin Invest. 2003, 111: 1805-1812.View ArticlePubMedPubMed ...
more infohttps://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2891
Category:Acute phase proteins - Wikimedia Commons  Category:Acute phase proteins - Wikimedia Commons
Akute-Phase-Protein (de); Proteínas de fase aguda (pt); Acute-phase protein (en); بروتين طور حاد (ar); 急性期蛋白 (zh); ... Proteine de phase aigue (fr); Akute-Phase-Proteine, Akut-Phase-Protein (de); Akutfasproteiner (sv); protein akutního stavu, ... Proteínas de fase aguda (es); Beljakovina akutne faze (sl); Protéine de phase aiguë (fr); protein akutní fáze (cs); ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Acute_phase_proteins&oldid=315167790" ...
more infohttps://commons.wikimedia.org/wiki/Category:Acute_phase_proteins
Acute-phase protein | immune system | Britannica.com  Acute-phase protein | immune system | Britannica.com
Acute-phase response: These proteins, collectively called acute-phase proteins, bind to bacteria and, by doing so, activate ... The acute-phase proteins act similarly to antibodies but are more democratic-that is, they do not distinguish between pathogens ... Other articles where Acute-phase protein is discussed: immune system: ... In immune system: Acute-phase response. These proteins, collectively called acute-phase proteins, bind to bacteria and, by ...
more infohttps://www.britannica.com/science/acute-phase-protein
Amyloidosis Overview | Centre for Amyloidosis and Acute Phase Proteins - UCL - Londons Global University  Amyloidosis Overview | Centre for Amyloidosis and Acute Phase Proteins - UCL - London's Global University
Amyloidosis and Acute Phase Proteins is part of the Division of Medicine. *Information for Patients ... Normal healthy proteins are cleared away at about the same rate that they are produced, but proteins that have formed amyloid ... The amyloid‑forming protein in AA amyloidosis is called serum amyloid A protein (SAA); the concentration of SAA in the blood ... The amyloid precursor protein is a blood protein called leucocyte chemotactic factor 2 (LECT2). This condition has been ...
more infohttps://www.ucl.ac.uk/amyloidosis/national-amyloidosis-centre/amyloidosis-overview
Agglutination of intravenous fat emulsions by acute-phase proteins  Agglutination of intravenous fat emulsions by acute-phase proteins
Kimura, T.; Yamamoto, K., 1987: Production of acute phase proteins in the liver. Mode of distribution of acute phase proteins ... Agglutination of intravenous lipid emulsions by acute phase proteins of inflammation. Agglutination of intravenous fat ... Agglutination of intravenous fat emulsions by acute inflammation phase proteins. Agglutination of intravenous fat emulsions ( ... Agglutination of intravenous fat emulsions by acute-phase proteins. Pathologie Biologie 36(7): 877-881. Agglutination of ...
more infohttps://eurekamag.com/research/001/748/001748355.php
Can acute phase proteins predict survival in ventilated patients with acute exacerbation of COPD? | European Respiratory Society  Can acute phase proteins predict survival in ventilated patients with acute exacerbation of COPD? | European Respiratory Society
Can acute phase proteins predict survival in ventilated patients with acute exacerbation of COPD?. Gamal Agmy, Hoda Maghlouf, ... PURPOSE: The aim of this study was to assess the correlation between acute phase proteins [High sensitivity C-reactive protein ... Can acute phase proteins predict survival in ventilated patients with acute exacerbation of COPD? ... Can acute phase proteins predict survival in ventilated patients with acute exacerbation of COPD? ...
more infohttp://erj.ersjournals.com/content/40/Suppl_56/P4818
Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes |...  Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes |...
Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes. The ... Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes ... Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes ... Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes ...
more infohttp://diabetes.diabetesjournals.org/content/51/4/1131
Increases in the serum acute phase proteins after ozone exposure are associated with induction of genes in the lung but not...  Increases in the serum acute phase proteins after ozone exposure are associated with induction of genes in the lung but not...
Increases in the serum acute phase proteins after ozone exposure are associated with induction of genes in the lung but not ... Increases in the serum acute phase proteins after ozone exposure are associated with induction of genes in the lung but not ... EPA Home » Science Inventory » Increases in the serum acute phase proteins after ozone exposure are associated with induction ... Ozone exposure increased positive acute phase proteins in the serum, such as α-1-acid glycoprotein, AGP; α-2-macroglobulin, A2M ...
more infohttps://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=270929
Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis...  Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis...
... and the serum concentration of two acute-phase proteins, C-reactive protein (CRP), and serum amyloid A (SAA). Serum albumin ... Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis ... Hypoalbuminemia in PD patients is a consequence of transperitoneal albumin losses and of the acute phase response. ... It has been postulated that hypoalbuminemia in the dialysis population is a consequence of poor protein intake resulting from ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/9398142?dopt=Abstract
The American Journal of Tropical Medicine and Hygiene | Acute-Phase Proteins and Serologic Profiles of Chagasic Children from...  The American Journal of Tropical Medicine and Hygiene | Acute-Phase Proteins and Serologic Profiles of Chagasic Children from...
Levels of alpha-2 macroglobulin (A2M) and C-reactive protein (CRP) increased in a significant number of children with acute ... In endemic areas, it is important to detect acute and even asymptomatic infections in children so that specific therapy can be ... The combined analysis of serologic and biochemical parameters can define the different stages of acute infection by Trypanosoma ... a late acute stage, with low IgM levels but high A2M, CRP, anti-Gal, and specific IgG levels. The detection of high IgG levels ...
more infohttp://www.ajtmh.org/content/journals/10.4269/ajtmh.1996.54.154
Regulation of Cytokines, Cytokine Inhibitors, and Acute-Phase Proteins Following Anti-TNF-α Therapy in Rheumatoid Arthritis |...  Regulation of Cytokines, Cytokine Inhibitors, and Acute-Phase Proteins Following Anti-TNF-α Therapy in Rheumatoid Arthritis |...
Association between circulating IL-6 and acute-phase proteins. Because IL-6 is the principal regulator of hepatic acute-phase ... Acute-phase proteins.. C-reactive protein (CRP) was measured by fluorescent polarization immunoassay using the TDX system ( ... In view of ample in vitro and animal data linking IL-6 with acute-phase protein synthesis in inflammation (28, 29), it was of ... It has been reported that IL-1ra is made by hepatocytes and by cells within the joint and behaves as an acute-phase protein. ...
more infohttp://www.jimmunol.org/content/163/3/1521.full
Functional Protection by Acute Phase Proteins α1-Acid Glycoprotein and α1-Antitrypsin Against Ischemia/Reperfusion Injury by...  Functional Protection by Acute Phase Proteins α1-Acid Glycoprotein and α1-Antitrypsin Against Ischemia/Reperfusion Injury by...
TNF-α by producing acute phase proteins, including α1-acid glycoprotein (AGP) and α1-antitrypsin (AAT).10 These 2 major acute ... Sepsis score and acute-phase protein response as predictors of outcome in septic surgical patients. Arch Surg. 1987;122:141-146 ... Hepatic acute phase protein mRNA expression 16 hours after either renal I/R, sham operation, administration of 30 μg of LPS IP ... Measurement of Hepatic Acute Phase Protein mRNA Content. Total RNA was extracted from livers and transcribed into cDNA, of ...
more infohttp://circ.ahajournals.org/content/102/12/1420
Serum concentrations of 10 acute-phase proteins in healthy term and preterm infants from birth to age 6 months.  Serum concentrations of 10 acute-phase proteins in healthy term and preterm infants from birth to age 6 months.
... retinol-binding protein, transferrin, ceruloplasmin, hemopexin, haptoglobin, alpha 1-ac ... Aiming to define the evolution pattern of 10 acute-phase proteins in early infancy, we measured nephelometrically the serum ... 0/Acute-Phase Proteins; 0/Orosomucoid; 0/Retinol-Binding Proteins; 0/Serum Albumin; 0/alpha 1-Antitrypsin; 0/alpha- ... Acute-Phase Proteins / analysis*. Adult. Aging / blood. Ceruloplasmin / analysis. Female. Gestational Age. Humans. Infant. ...
more infohttp://www.biomedsearch.com/nih/Serum-concentrations-10-acute-phase/7536645.html
HIV infection and drugs of abuse: role of acute phase proteins | Journal of Neuroinflammation | Full Text  HIV infection and drugs of abuse: role of acute phase proteins | Journal of Neuroinflammation | Full Text
Acute phase proteins such as C-reactive protein (CRP) and serum amyloid A (SAA) are the biomarkers of inflammation. Hence, the ... interactive effect of drugs of abuse with acute phase proteins in HIV-positive subjects was investigated. Plasma samples were ... Inflammatory proteins such as C-reactive protein (CRP) and serum amyloid A (SAA) are the plasma proteins known as acute phase ... Acute phase proteins such as C-reactive protein (CRP) and serum amyloid A (SAA) are the biomarkers of inflammation. Hence, the ...
more infohttps://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-10-113
Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human...  Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human...
Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human ... Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human ... Objective: To investigate the influence of p38 MAPK inhibition on acute phase protein (APP) production, which is dependent on ... Results: Two out of four cell lines produced C reactive protein (CRP), especially after combined IL6 and IL1β stimulation. CRP ...
more infohttp://ard.bmj.com/content/65/7/929
MicroRNA-18a enhances the interleukin-6-mediated production of the acute-phase proteins fibrinogen and haptoglobin in human...  MicroRNA-18a enhances the interleukin-6-mediated production of the acute-phase proteins fibrinogen and haptoglobin in human...
MicroRNA-18a enhances the interleukin-6-mediated production of the acute-phase proteins fibrinogen and haptoglobin in human ... which rapidly induces the production of acute-phase proteins such as haptoglobin and fibrinogen. Another target of the IL-6/ ... which rapidly induces the production of acute-phase proteins such as haptoglobin and fibrinogen. Another target of the IL-6/ ... MicroRNA-18a enhances the interleukin-6-mediated production of the acute-phase proteins fibrinogen and haptoglobin in human ...
more infohttps://www.zora.uzh.ch/id/eprint/52991/
Effects of low-protein diets on acute phase proteins and heat shock protein 70 responses, and growth performance in broiler...  Effects of low-protein diets on acute phase proteins and heat shock protein 70 responses, and growth performance in broiler...
"Effects of low-protein diets on acute phase proteins and heat shock protein 70 responses, and growth performance in broiler ... Effects of low-protein diets on acute phase proteins and heat shock protein 70 responses, and... Zulkifli, I;Akmal, A F; ... Effects of low-protein diets on acute phase proteins and heat shock protein 70 responses, and growth performance in broiler ... Effects of low-protein diets on acute phase proteins and heat shock protein 70 responses, and growth performance in broiler ...
more infohttps://www.deepdyve.com/lp/oxford-university-press/effects-of-low-protein-diets-on-acute-phase-proteins-and-heat-shock-OAvf0Kl7Vc
Acute-phase proteins | definition of acute-phase proteins by Medical dictionary  Acute-phase proteins | definition of acute-phase proteins by Medical dictionary
What is acute-phase proteins? Meaning of acute-phase proteins medical term. What does acute-phase proteins mean? ... Looking for online definition of acute-phase proteins in the Medical Dictionary? acute-phase proteins explanation free. ... decrease and are known as negative acute-phase proteins.. Plasma proteins as biomarkers: acute phase proteins ... medical-dictionary.thefreedictionary.com/acute-phase+proteins',acute-phase proteins,/a,. *Facebook ...
more infohttps://medical-dictionary.thefreedictionary.com/acute-phase+proteins
  • In contrast, C-reactive protein (with a half-life of 6-8 hours) rises rapidly and can quickly return to within the normal range if treatment is employed. (wikipedia.org)
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