Cluster Headache: A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Tryptamines: Decarboxylated monoamine derivatives of TRYPTOPHAN.Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.Migraine with Aura: A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Vascular Headaches: Secondary headache disorders attributed to a variety of cranial or cervical vascular disorders, such as BRAIN ISCHEMIA; INTRACRANIAL HEMORRHAGES; and CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS.Migraine without Aura: Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Headache Disorders: Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Serotonin Receptor Agonists: Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.Ergotamine: A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.Dihydroergotamine: A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.Tension-Type Headache: A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to moderate intensity in the HEAD; SCALP; or NECK. The subtypes are classified by frequency and severity of symptoms. There is no clear cause even though it has been associated with MUSCLE CONTRACTION and stress. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Trigeminal Nerve: The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.Analgesics: Compounds capable of relieving pain without the loss of CONSCIOUSNESS.Trigeminal Autonomic Cephalalgias: Primary headache disorders that show symptoms caused by the activation of the AUTONOMIC NERVOUS SYSTEM of the TRIGEMINAL NERVE. These autonomic features include redness and tearing of the EYE, nasal congestion or discharge, facial SWEATING and other symptoms. Most subgroups show unilateral cranial PAIN.Receptors, Calcitonin Gene-Related Peptide: Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.Clonixin: Anti-inflammatory analgesic.Headache Disorders, Primary: Conditions in which the primary symptom is HEADACHE and the headache cannot be attributed to any known causes.Receptor, Serotonin, 5-HT1D: A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.Pizotyline: Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.Pterygopalatine Fossa: A small space in the skull between the MAXILLA and the SPHENOID BONE, medial to the pterygomaxillary fissure, and connecting to the NASAL CAVITY via the sphenopalatine foramen.Headache Disorders, Secondary: Conditions with HEADACHE symptom that can be attributed to a variety of causes including BRAIN VASCULAR DISORDERS; WOUNDS AND INJURIES; INFECTION; drug use or its withdrawal.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Acute Disease: Disease having a short and relatively severe course.Meningeal Arteries: Arteries which supply the dura mater.Calcitonin Gene-Related Peptide: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Receptor, Serotonin, 5-HT1B: A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.Naproxen: An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.Dura Mater: The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Trigeminal Nucleus, Spinal: Nucleus of the spinal tract of the trigeminal nerve. It is divided cytoarchitectonically into three parts: oralis, caudalis (TRIGEMINAL CAUDAL NUCLEUS), and interpolaris.Injections: Introduction of substances into the body using a needle and syringe.Alkadienes: Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.Spinal Nerves: The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.Cortical Spreading Depression: The decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA. (Campbell's Psychiatric Dictionary, 8th ed.)Receptors, Serotonin: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.Paroxysmal Hemicrania: A primary headache disorder that is similar to the CLUSTER HEADACHE with unilateral head pain, but differs by its multiple short severe attacks. It is usually seen in females, and may be responsive to non-steroidal-anti-inflammatory drugs (NSAIDS).Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Trigeminal Ganglion: The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.Trigeminal Caudal Nucleus: The caudal portion of the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), a nucleus involved with pain and temperature sensation.Anisocoria: Unequal pupil size, which may represent a benign physiologic variant or a manifestation of disease. Pathologic anisocoria reflects an abnormality in the musculature of the iris (IRIS DISEASES) or in the parasympathetic or sympathetic pathways that innervate the pupil. Physiologic anisocoria refers to an asymmetry of pupil diameter, usually less than 2mm, that is not associated with disease.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Serotonin 5-HT1 Receptor Agonists: Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.Orbit: Bony cavity that holds the eyeball and its associated tissues and appendages.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Miosis: Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.Hypothalamus: Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
The other primarily recommended treatment of acute attacks is subcutaneous or intranasal sumatriptan. Sumatriptan and ... "The role of nerve blocks and botulinum toxin injections in the management of cluster headaches". Current Pain and Headache ... Cluster headache may be misdiagnosed as migraine or sinusitis. Other types of headache are sometimes mistaken for, or may mimic ... If left untreated, attack frequency may range from one attack every two days to eight attacks per day. Cluster headache attack ...
"Treatment of acute cluster headache with sumatriptan. The Sumatriptan Cluster Headache Study Group". N Engl J Med. 325 (5): 322 ... Sumatriptan is a medication used for the treatment of migraine and cluster headaches. It is a synthetic drug belonging to the ... "Sumatriptan (all routes of administration) for acute migraine attacks in adults - overview of Cochrane reviews". The Cochrane ... Par Pharmaceutical announced that it would begin shipping generic versions of sumatriptan injection (sumatriptan succinate ...
... and this was the first clue that sumatriptan might have a direct neuronal effect in migraine attacks. Sumatriptan became a ... Law, S; Derry, S; Moore, R. A. (2013). "Triptans for acute cluster headache". The Cochrane Database of Systematic Reviews. 7 (7 ... Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches ... For sumatriptan, a number of other application forms are marketed: suppositories, a subcutaneous injection, a iontophoretic ...
Sumatriptan injection is used to treat acute migraine attacks and cluster headaches in adults. Sumatriptan works in the brain ... Do not use this medicine for a migraine or cluster headache that is different from your usual headaches. Instead, check with ... For injection dosage form: *For migraine or cluster headaches: *Adults- *Alsuma™, Imitrex®, and Sumavel®: 4 or 6-milligram (mg ... Cluster Headaches prednisone, verapamil, sumatriptan, Imitrex, indomethacin, cyproheptadine, Indocin, Deltasone, Calan, Verelan ...
Discover more about Cluster Headaches, what causes them, and how to get treatment. Treatment ranges from medicinal intervention ... Sumatriptan (Imitrex) has been demonstrated to be effective in migraine headaches and in acute cluster headache attacks. It is ... given as a subcutaneous injection at the start of an attack.. Corticosteroid medications, such as prednisone, may be prescribed ... In contrast to patients with migraine headaches, patients with cluster headaches are restless, active, and even violent during ...
Oxygen and sumatriptan injection are sometimes given together.. Other drugs that may be used for acute attacks are nasal sprays ... History of Migraine. About half of people with cluster headache have a personal or family history of migraine. It is possible ... Headaches That Resemble Cluster Headaches. Cluster headaches are a type of primary headache. A headache is considered primary ... which may provoke cluster headache attacks.. Cluster Headache Survey. Results from the U.S. Cluster Headache Survey, the ...
... which is indicated for the acute treatment of migraine attacks with or without aura, and cluster headache episodes ... ALSUMA is not used to treat other types of headaches or used to prevent or lessen the number of migraine or cluster headaches ... which is indicated for the acute treatment of migraine attacks with or without aura, and cluster headache episodes. ALSUMA is a ... You may take a second injection at least 1 hour after your first dose if your migraine or cluster headache symptoms come back ...
Sumatriptan Injection, USP is not indicated for the prevention of migraine or cluster headache attacks. ... What is sumatriptan? Sumatriptan Injection, USP is a prescription medicine used to treat acute migraine headaches with or ... 14.2 Cluster Headache The efficacy of sumatriptan injection in the acute treatment of cluster headache was demonstrated in 2 ... If a patient has no response to the first migraine or cluster headache attack treated with Sumatriptan Injection, USP, ...
... subcutaneous sumatriptan for the treatment of acute migraine and cluster headache. In clinical studies1, sumatriptan injection ... sumatriptan injection) is indicated for the acute treatment of migraine attacks, with or without aura, and the acute treatment ... have been diagnosed with acute migraine or cluster headaches. Under terms of the agreement, Mallinckrodts U.S. sales force ... of cluster headache episodes. SUMAVEL DosePro should only be used where a clear diagnosis of migraine or cluster headache has ...
An Injection of sumatriptan (Imitrex, generic) is the standard triptan treatment and is FDA-approved for cluster headaches.. ... Other headaches that resemble migraines include SUNCT (short-lasting unilateral neuralgiform headache attacks with conjunctival ... Oxygen therapy and sumatriptan (Imitrex, generic) injection are the most effective treatments for acute attacks. The proteins ... and prevention of cluster headaches. HighlightsWhat Are Cluster Headaches?Cluster headaches are among the most painful types of ...
Contact the Headache and Facial Pain Program at Tufts Medical Center in Boston to learn more about treatment options for head ... We treat cluster headache aggressively, beginning with Imitrex injections and/or oxygen inhalation to counter the acute pain. ... What types of headaches do we treat?. Chronic migraine involves headache on a daily or near daily basis with severe migraine ... Cluster headache, a rare condition, is perhaps the most painful form of headache. Attacks occur daily (often several times per ...
Often this is successful at aborting an attack. Another effective, acute treatment is subcutaneous sumatriptan. When injected ... Migraine headaches are most commonly mistaken for CH. Migraines usually cause pain on only one side of the head as well, ... SUNCT (short-lasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing) syndrome is a disorder ... Cluster Headaches. National Headache Foundation. http://www.headaches.org/education/Headache_Topic_Sheets/Cluster_Headaches. ...
It received its name from the clustering, or pattern, of frequent headaches that usually occur. ... Cluster headache is a type of severe, recurring pain that is located on one side of the head. ... Drugs used to treat migraines often relieve acute attacks of cluster headaches. These drugs must be taken at the first sign of ... Drugs used to treat cluster headaches include:. *Sumatriptan, zolmitriptan, or other triptans (given as an injection or nasal ...
Cluster headache is a rare but very severe type of headache that affects less than 1% of the population. It is six times more ... Sumatriptan injections have been found to reduce the pain within 10 minutes during an attack. In general tablets are not ... Acute treatment is used to stop the pain once it has started. Treating cluster headache can be tricky because the pain becomes ... Cluster Headaches. What is Cluster Headache?. *Cluster Headache, is a condition considered to be one of the worst pains known ...
Acute treatment of migraine attacks. Subcutaneous: Acute treatment of cluster headache episodes. ... Sumatriptan succinate injection is marketed by GlaxoSmithKline under the brand name Imitrex and is used for the acute treatment ... Acute migraine, cluster headaches. Adults: Initially, 25 mg P.O.; if response inadequate after 2 hours, may give up to 100 mg P ... sumatriptan succinate. Apo-Sumatriptan (CA), Co Sumatriptan (CA), Dom-Sumatriptan (CA), Gen-Sumatriptan (CA), Imigran (UK), ...
... and is used for the treatment of cluster headaches and acute migraine attacks. It is available in many forms - tablets, ... Sumatriptan is a migraine and cluster headache medication, which should be taken as the headache develops. You should not sit ... injection, dissolvable tablets, and injection. When a migraine attack comes on, the chemicals in the brain go into overdrive, ... headache confined to the back of the head. *recent marked deterioration in migraine (duration, severity or frequency of attacks ...
For example, treatment choices for acute migraine are based on headache severity, attack frequency, associated symptoms, and co ... Injection therapy has not shown long term benefit for the treatment of headaches/migraines outside of cluster headaches. While ... Options for outpatient rescue include SC sumatriptan, DHE injection or intranasal spray, or corticosteroids. Inpatient options ... Headaches. *Chronic Migraine: Migraine is a common disabling primary headache disorder. Chronic migraine headache is defined as ...
Cluster headache (CH) is a type of primary headache disorder that is characterized by a group of headaches occurring typically ... treatment of acute attacks and 2) preventive treatment that aims to suppress ongoing attacks. According to evidence-based ... headache and migraine disorders are greatly underrated and underreported by health systems and receive too little attention.11 ... for acute treatment utilizing subcutaneous sumatriptan, zolmitriptan nasal spray, and high-flow oxygen (12 to 15 L/minute) ...
Clarified MN criterion I. D. for the acute treatment of migraine attacks with aura, removing "headache" from "…another headache ... When paired comparisons were performed, DHE was equivalent to sumatriptan. Although there are relatively few studies involving ... injection for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache ... migraine attacks with aura, 2) migraine attacks without aura, and 3) cluster headache episodes. Clarified the Not Medically ...
4mg Sumatriptan Statdose injection for use as acute therapy in a cluster headache. Consistency of response in three attacks ... The percentage of attacks of migraine that result in resolution of all associated symptoms of cluster headache present at the ... Subjects with episodic cluster headache have a history of continuing to have cluster headaches at least once every other day ... Episodic Cluster Headache Chronic Cluster Headache Drug: Sumatriptan 4mg Statdose injection Phase 4 ...
For the acute treatment of migraine attacks with or without aura. NOTE: Sumatriptan is not indicated for hemiplegic or basilar ... Safety and efficacy have not been established in cluster headaches. Sumatriptan should not be administered if the headache is ... If headache returns following initial treatment with sumatriptan injection, additional oral doses of up to 100 mg/day total may ... Imitrex/Migraine Pack/Sumatriptan/Sumatriptan Succinate Oral Tab: 25mg, 50mg, 100mg. Imitrex/Sumatriptan Nasal Spray Met: ...
... the safety and efficacy of gammaCore for the acute treatment of migraine attacks and the prevention of episodic migraine, ... savings opportunity if the use of gammaCore results in a reduction in use of rescue medications such as sumatriptan injections ... Cluster headaches. Cleveland Clinic website. my.clevelandclinic.org/health/articles/cluster-headaches. Reviewed July 22, 2014. ... Göbel H, Lindner V, Heinze A, Ribbat M, Deuschl G. Acute therapy for cluster headache with sumatriptan: findings of a one-year ...
Migraines should be differentiated from other types of headache, including cluster headaches and tension headaches ... Treatments for migraine can be regarded in two broad ways: acute medications when the attack starts and preventive medications ... The only migraine-specific medications are the triptans. There are seven in the family: sumatriptan, zolmitriptan, naratriptan ... Injectables These include Botox (licensed for chronic migraine or steroid and local anaesthetic occipital nerve injections. ...
This therapy is given as a monthly subcutaneous injection and ongoing clinical trials for the agent are for episodic and ... CGRP levels increase during acute migraine attacks in migraine-suffering patients but normalize after efficacious sumatriptan ... injection and ongoing clinical trials for the agent are for episodic and chronic migraine as well as cluster headaches [3]. ... The ongoing trials for fremanezumab are for episodic and chronic migraine prevention and also for cluster headache [3]. ...
HEADACHE Causes, Patient Concerns and Latest Treatments and Percocet Reports and Side Effects. ... Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache. Conditions: Episodic Cluster Headache. ; Chronic Cluster ... Headache. frequency; Duration of Headache. ; Intensity of Headache. ; Frequency of probable migraine attacks; Headache. related ... Drug: Sumatriptan 4mg Statdose injection. Outcome Measures: The primary efficacy parameters will be the percentage of cluster ...
If you suffer from tension headaches and would like more information on headache treatment, contact Dr. Ira Shapira located in ... Subcutaneous injection and nasal spray of sumatriptan are known to be useful for the treatment of acute phase of cluster ... After her final she went to the ER and she was told she was in a full blown migraine attack and was given a shot for the pain ... high flow oxygen is also reported to abort the attack of cluster headache. For preventive treatment of cluster headache, ...
A migraine is classified as a primary headache and is considered the most common cause of recurrent headache in children. Read ... more to learn about migraines in children, its precursors, diagnosis and management. ... children have headaches too which can be either primary or secondary type. ... A headache in Children. Cluster headache. Is a severe brief attack of a frontal headache associated with autonomic symptoms of ...
Cluster headache attacks typically occur 1-3 times daily. How quickly do they onset, and how long do they typically last? ... Cluster headaches, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headaches with conjunctival injection and ... Hemiplegic migraines (12-17). Retinal migraines (under 40). Recurrent painful ophthalmoplegic neuropathy. Cluster headaches (27 ... What are some of the acute treatment options for cluster headaches? 100% oxygen therapy, subcutaneous or nasal sumatriptan ...