A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Pathological processes involving any part of the LUNG.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
An abnormal increase in the amount of oxygen in the tissues and organs.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
Infection of the lung often accompanied by inflammation.
Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Artificial respiration (RESPIRATION, ARTIFICIAL) using an oxygenated fluid.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Tumors or cancer of the LUNG.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
Mechanical devices used to produce or assist pulmonary ventilation.
The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Disease having a short and relatively severe course.
Injuries incurred during participation in competitive or non-competitive sports.
Measurement of oxygen and carbon dioxide in the blood.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
The circulation of the BLOOD through the LUNGS.
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
The posture of an individual lying face down.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.
The transference of either one or both of the lungs from one human or animal to another.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Hospital units providing continuous surveillance and care to acutely ill patients.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
Ventilatory support system using frequencies from 60-900 cycles/min or more. Three types of systems have been distinguished on the basis of rates, volumes, and the system used. They are high frequency positive-pressure ventilation (HFPPV); HIGH-FREQUENCY JET VENTILATION; (HFJV); and high-frequency oscillation (HFO).
Elements of limited time intervals, contributing to particular results or situations.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
General or unspecified injuries involving the leg.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
That part of the RESPIRATORY TRACT or the air within the respiratory tract that does not exchange OXYGEN and CARBON DIOXIDE with pulmonary capillary blood.
Techniques for supplying artificial respiration to a single lung.
An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
A disease or state in which death is possible or imminent.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
The number of times an organism breathes with the lungs (RESPIRATION) per unit time, usually per minute.
The force per unit area that the air exerts on any surface in contact with it. Primarily used for articles pertaining to air pressure within a closed environment.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Health care provided to a critically ill patient during a medical emergency or crisis.
Drugs used for their effects on the respiratory system.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A pathological condition manifested by failure to perfuse or oxygenate vital organs.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
Burns of the respiratory tract caused by heat or inhaled chemicals.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)
Substances that reduce or suppress INFLAMMATION.
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
General or unspecified injuries to the chest area.
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
Inflammation of the lung parenchyma that is caused by bacterial infections.
General or unspecified injuries involving organs in the abdominal cavity.
The dialdehyde of malonic acid.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Relatively complete absence of oxygen in one or more tissues.
General or unspecified injuries involving the arm.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
General or unspecified injuries to the hand.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A greenish-yellow, diatomic gas that is a member of the halogen family of elements. It has the atomic symbol Cl, atomic number 17, and atomic weight 70.906. It is a powerful irritant that can cause fatal pulmonary edema. Chlorine is used in manufacturing, as a reagent in synthetic chemistry, for water purification, and in the production of chlorinated lime, which is used in fabric bleaching.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Hospital units providing continuous surveillance and care to acutely ill infants and children. Neonates are excluded since INTENSIVE CARE UNITS, NEONATAL is available.
Epithelial cells that line the PULMONARY ALVEOLI.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Injuries involving the vertebral column.
A fibroblast growth factor that is a specific mitogen for EPITHELIAL CELLS. It binds a complex of HEPARAN SULFATE and FIBROBLAST GROWTH FACTOR RECEPTOR 2B.
A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.
Injuries to the knee or the knee joint.
A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
The measurement of an organ in volume, mass, or heaviness.
Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
General or unspecified injuries to the heart.
Liquid components of living organisms.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.
A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
Classification system for assessing impact injury severity developed and published by the American Association for Automotive Medicine. It is the system of choice for coding single injuries and is the foundation for methods assessing multiple injuries or for assessing cumulative effects of more than one injury. These include Maximum AIS (MAIS), Injury Severity Score (ISS), and Probability of Death Score (PODS).
An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
The relationship between the dose of an administered drug and the response of the organism to the drug.
Bleeding or escape of blood from a vessel.
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.
A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.
General or unspecified injuries to the soft tissue or bony portions of the face.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
A type of shock that occurs as a result of a surgical procedure.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.
The natural enzymatic dissolution of FIBRIN.
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Transfusion related acute lung injury (TRALI) caused by red blood cell transfusion involving residual plasma anti-HLA antibodies: a report on two cases and general considerations. (1/1061)

TRALI is considered a serious hazard among immune complications of blood transfusion and its occurrence is admitted to be globally underestimated. Each type of blood product is likely to cause TRALI. We report here on two consecutive observations of TRALI caused by red blood cell concentrates, in which anti-HLA class I and class II antibodies resulting from post-gravitational allo-immunization were evidenced in donors. HLA class I and II antigenic community between recipients and donors' husbands were found and strong reacting IgG antibodies directed at several of those common antigens were detected in the donors' serum. Both donors had more than 3 pregnancies, raising the issue of blood donor selection or of plasma reduction for cellular products.  (+info)

Mechanisms of pulmonary dysfunction after on-pump and off-pump cardiac surgery: a prospective cohort study. (2/1061)

BACKGROUND: Pulmonary dysfunction following cardiac surgery is believed to be caused, at least in part, by a lung vascular injury and/or atelectasis following cardiopulmonary bypass (CPB) perfusion and collapse of non-ventilated lungs. METHODS: To test this hypothesis, we studied the postoperative pulmonary leak index (PLI) for 67Ga-transferrin and (transpulmonary) extravascular lung water (EVLW) in consecutive patients undergoing on-pump (n = 31) and off-pump (n = 8) cardiac surgery. We also studied transfusion history, radiographs, ventilatory and gas exchange variables. RESULTS: The postoperative PLI and EVLW were elevated above normal in 42 and 29% after on-pump surgery and 63 and 37% after off-pump surgery, respectively (ns). Transfusion of red blood cell (RBC) concentrates, PLI, EVLW, occurrence of atelectasis, ventilatory variables and duration of mechanical ventilation did not differ between groups, whereas patients with atelectasis had higher venous admixture and airway pressures than patients without atelectasis (P = 0.037 and 0.049). The PLI related to number of RBC concentrates infused (P = 0.025). CONCLUSION: The lung vascular injury in about half of patients after cardiac surgery is not caused by CPB perfusion but by trauma necessitating RBC transfusion, so that off-pump surgery may not afford a benefit in this respect. However, atelectasis rather than lung vascular injury is a major determinant of postoperative pulmonary dysfunction, irrespective of CPB perfusion.  (+info)

Toward early identification of acute lung injury in the emergency department. (3/1061)

BACKGROUND: There are no studies evaluating the epidemiology of pediatric acute lung injury (ALI) in the emergency department (ED), where early identification and interventions are most likely to be helpful. The purpose of this study was to describe the epidemiology of the ALI precursor acute hypoxemic respiratory failure (AHRF) in the ED. METHODS: We analyzed 11,664 pediatric patient records from 16 EDs. Records were selected if oxygen saturation (SpO(2)) was recorded during the visit. Virtual partial pressure of oxygen (pO(2)) was calculated from SpO(2), thus allowing calculation of ratios of pO(2) to fraction of inspired oxygen (FiO(2)) (PFRs). Patients with a PFR < 300 were classified as having AHRF. Univariate analyses and logistic regression were used to test the association of clinical factors with the presence of AHRF and intubation. RESULTS: AHRF criteria (ie, PFR < 300) were met in 121 (2.9%) of the 4,184 patients with an oxygenation measurement. The following variables were independently associated with ALI: higher Pediatric Risk of Admission II score (adjusted odds ratio [95% confidence interval (CI)] = 1.12 [1.08-1.16]; p < .001), higher heart rate (1.02 [1.01-1.03]; p = .009), a positive chest radiograph (2.35 [1.02-5.43]; p = .045), and lower temperature (0.49 [0.36-0.68]; p < .001).The final model had an R(2) = .20. CONCLUSION: We found nonintubated AHRF to be prevalent in the ED. The low R(2) for the regression model for AHRF underscores the lack of criteria for early identification of patients with respiratory compromise. Our findings represent an important first step toward establishing the true incidence of ALI in the pediatric ED.  (+info)

Keratinocyte growth factor protects against Clara cell injury induced by naphthalene. (4/1061)

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NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells. (5/1061)

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Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury. (6/1061)

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Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. (7/1061)

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Predictors of mortality in acute lung injury during the era of lung protective ventilation. (8/1061)

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Recipient factors,ref,Vlaar AP, et al. Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Crit Care Med. 2007;176:886,/ref,,ref,Gajic O, et al. Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med. 2007;176:886,/ref,,ref name=fifteen,Toy P, et al. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012;119:1757,/ref,,ref,Benson AB, et al. Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding. Intensive Care Med. 2010;36:1710,/ref ...
Non-critically ill with TRALI - 5-7% ,ref,Looney MR, et al. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury. Crit Care Med. 2014;42:1676,/ref,,ref,Popovsky MA, et al. Transfusion-related acute lung injury: a neglected serious complication of hemotherapy. Transfusion. 1992;32:589,/ref,,ref,Sillman CC, et al. Transfusion-related acute lung injury (TRALI): current concepts and misconceptions. Blood Rev. 2009;23:245,/ref ...
Data & statistics on Acute Lung Injury: MRNA expression of Interleukin-8 in bronchoalveolar lavage fluid cells before injury and after injury. NG, acute lung injury with normoglycemia group; HG, acute lung injury with hyperglycemia group; HG-VI, acute lung injury with hyperglycemia treated with intravenous insulin group; HG-AI, acute lung injury with hyperglycemia treated with aerosolized insulin group; IL-8, interleukin-8. Boxes extend ..., Particle-induced acute lung injury. Results obtained from analysis performed on bronchoalveolar lavage fluid samples recovered from animals at 24 h post-exposure. Animals were exposed by intratracheal instillation to: saline ( E); OFA100 ( C); OFA400 (P); ROFA#6 ( 1); or ARD ([). Various biomarkers of acute lung injury were assessed such as: A) edema/secretory activity (protein/mL); B) edema (albumin/mL); ..., Inhaltsverzeichnis Einleitung Hypothesen Theoretische Grundlagen der Hypothesen Patienten und Methodik Patienten Pneumonie Acute lung injury / Acute
Request for Free Sample Report: https://www.delveinsight.com/sample-request/acute-lung-injury-market. Table of Contents:. 1. Key Insights. 2. Executive Summary of Acute Lung Injury. 3. Competitive Intelligence Analysis for Acute Lung Injury. 4. Acute Lung Injury: Market Overview at a Glance. 5. Acute Lung Injury: Disease Background and Overview. 6. Patient Journey. 7. Acute Lung Injury Epidemiology and Patient Population. 8. Treatment Algorithm, Current Treatment, and Medical Practices. 9. Unmet Needs. 10. Key Endpoints of Acute Lung Injury Treatment. 11. Marketed Products. List to be continued in report. 12. Emerging Therapies. List to be continued in report. 13. Acute Lung Injury: Seven Major Market Analysis. 14. Attribute analysis. 15. 7MM: Market Outlook. 16. Access and Reimbursement Overview of Acute Lung Injury. 17. KOL Views. 18. Market Drivers. 19. Market Barriers. 20. Appendix. 21. DelveInsight Capabilities. 22. Disclaimer. 23. About DelveInsight. About DelveInsight ...
Transfusion-related acute lung injury is emerging as a common cause of transfusion-related adverse events. However, awareness about this entity in the medical fraternity is low and it, consequently, remains a very under-reported and often an under-diagnosed complication of transfusion therapy. We report a case of a 46-year old woman who developed acute respiratory and hemodynamic instability following a single unit blood transfusion in the postoperative period. Investigation results were non-specific and a diagnosis of transfusion-related acute lung injury was made after excluding other possible causes of acute lung injury. She responded to symptomatic management with ventilatory and vasopressor support and recovered completely over the next 72 hours. The diagnosis of transfusion-related acute lung injury relies on excluding other causes of acute pulmonary edema following transfusion, such as sepsis, volume overload, and cardiogenic pulmonary edema. All plasma containing blood products have been
Transfusion-Related Acute Lung Injury (TRALI) is an important life-threatening complication that is related with blood transfusion. The frequency is reported as 1/5.000. It is generally characterized with hypoxia that appears at the 2-6th hours after the blood transfusion, bilateral infiltration in the chest radiography, and non-cardiogenic pulmonary edema. Acute respiratory distress, hypotension, tachycardia and fever accompany the clinical picture. Past surgery, blood transfusion, and sepsis are among the factors that trigger the disease. In this study, the efficiency of the hemodialysis applied in the right time in the treatment of a heavy TRALI case developed after a blood transfusion has been presented.. Keywords: Acute lung injury, efficiency, hemodialysis, ...
Medical information, Acute lung injury. Definition of Acute lung injury, symptoms of Acute lung injury, treatment of Acute lung injury, and prevention of Acute lung injury. Exams and Tests Acute lung injury.
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of hemotherapy. We report a series of 90 TRALI reactions in 81 patients seconda
TY - JOUR. T1 - Human immunodeficiency virus infection and hospital mortality in acute lung injury patients. AU - Mendez-Tellez, Pedro A.. AU - Damluji, Abdulla. AU - Ammerman, Douglas. AU - Colantuoni, Elizabeth. AU - Fan, Eddy. AU - Sevransky, Jonathan E.. AU - Shanholtz, Carl. AU - Gallant, Joel E.. AU - Pronovost, Peter J.. AU - Needham, Dale M.. PY - 2010/7. Y1 - 2010/7. N2 - Objective: To evaluate the impact of human immunodeficiency virus infection on hospital mortality in patients with acute lung injury and to evaluate predictors of mortality among acute lung injury patients with human immunodeficiency virus. Design, setting, and patients: Retrospective study of human immunodeficiency virus-infected patients enrolled in an ongoing prospective cohort study of acute lung injury patients conducted at 13 intensive care units in four teaching hospitals in Baltimore, Maryland. Measurements and main results: Of 520 consecutive acute lung injury patients, 66 (13%) were human immunodeficiency ...
The report titled, Acute Lung Injury Treatment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017 - 2025 by TMR Research furnishes an in-depth analysis of the vital catalysts and deterrents of the global market for acute lung injury treatment, alongside accurate figures, charts, diagrams, and graphs. The report offers an insightful assessment of the leading geographical segments and the growth opportunities offered by each of them. Acute lung injury is a prominent cause of morbidity and mortality across the world. Since one of the common conditions that is associated with severe hypoxia is acute lung injury, acute lung injury treatment market is expected to soar as its incidence keeps escalating worldwide, augmenting mortality rates. Researchers can now have access to critical information pertaining to the pathophysiology of the condition as well as numerous biological markers related to worse clinical outcomes of patients, thanks to the recent technological ...
Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored intensively so far. In this study, we mainly analyzed the relationship between ferroptosis and LPS-induced ALI. In this study, a human bronchial epithelial cell line, BEAS-2B, was treated with LPS and ferrostatin-1 (Fer-1, ferroptosis inhibitor). The cell viability was measured using CCK-8. Additionally, the levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and iron, as well as the protein level of SLC7A11 and GPX4, were measured in different groups. To further confirm the in vitro results, an ALI model was induced by LPS in mice, and the therapeutic action of Fer-1 and ferroptosis level in lung tissues were evaluated. The cell viability of BEAS-2B was down-regulated by LPS treatment, together with the ferroptosis markers SLC7A11 and GPX4,
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecula …
Histone deacetylase (HDAC) inhibitors, developed as promising anti-tumor drugs, exhibit their anti-inflammatory properties due to their effects on reduction of inflammatory cytokines. To investigate the protective effect of butyrate, a HDAC inhibitor, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. ALI was induced in Balb/c mice by intratracheally instillation of LPS (1 mg/kg). Before 1 hour of LPS administration, the mice received butyrate (10 mg/kg) orally. The animals in each group were sacrificed at different time point after LPS administration. Pulmonary histological changes were evaluated by hematoxylin-eosin stain and lung wet/dry weight ratios were observed. Concentrations of interleukin (IL)-1β and tumor necrosis factor (TNF)-α in bronchoalveolar lavage fluid (BALF) and concentrations of nitric oxide (NO) and myeloperoxidase (MPO) activity in lung tissue homogenates were measured by enzyme-linked immunosorbent assay (ELISA). Expression of nuclear factor (NF)-κB p65 in
GlobalDatas clinical trial report, Acute Lung Injury Global Clinical Trials Review, H2, 2012 provides data on the Acute Lung Injury clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Acute Lung Injury. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Acute Lung Injury. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts. Note: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.
Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) and induce the production of regulatory dendritic cells (DCregs), but the potential link between these two cell types remains unclear. The goal of this study was to investigate the effect and mechanism of MSC-induced regulatory dendritic cells in ALI mice. In vivo experiments, C57BL/6 wild-type male mice were sacrificed at different times after intratracheal injection of LPS to observe changes in lung DC maturation and pathological damage. MSCs, DCregs or/and carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeled DCs were administered to the mice by tail vein, and flow cytometry was performed to measure the phenotype of lung DCs and T cells. Lung injury was estimated by the lung wet weight/body weight ratio and histopathological analysis. In vitro, Western blotting or flow cytometry was used to detect the expression of Notch ligand or receptor in MSCs or DCs after coculture or LPS stimulation. Finally, in vivo and
The pathogenesis of hyperlactatemia during sepsis is poorly understood. We have previously described an increase in lactate concentration across the lung in the dog during early endotoxemia. Accordingly, we sought to determine if the lung releases lactate in humans and what relation this has with lung injury. Methods: We measured lactate concentrations across the lung and lung injury scores (LIS) in two groups of patients. Group 1 consisted of nine patients with acute lung injury (LIS ≤2.0) and elevated lactate concentrations (,2.0 mmol/L). Group 2 contained 12 patients with no acute lung injury (LIS scores ≤1.5), with or without increased lactate concentrations. Simultaneous measurements of plasma lactate and blood gases were obtained from indwelling arterial and pulmonary artery, catheters. Measurements of cardiac output were also obtained. Lactate measurements were done using a lactate analyzer (YSI; Yellow Springs, Ohio). Results: For each patient with acute lung injury and ...
The acute lung injury progresses as lung damage mediated by many cellular (e.g., macrophages) and humoral (e.g., chemical mediators) immunological components, which constitute a complex network to amplify inflammatory responses, leading to acute lung injury. [14] In particular, activated neutrophils are thought to play an important role in formation of the network by releasing reactive oxygen species, proteases, and cytokines. [14] These potent mediators primarily attack the endothelial and epithelial cells. In this pathway, chemotaxins including IL-8 and thromboxane B2promote accumulation of neutrophils in the lung. [33,34] In the current study, intratracheal instillation of infant formula or breast milk increased infiltration of neutrophils into the alveolar spaces as well as decreasing the peripheral leukocyte counts. These changes were less prominent in the surfactant-treated rabbits. Our observations suggest that surfactant treatment mitigated recruitment of neutrophils to the lung. ...
Bone marrow mesenchymal stem cell (BMSCs)-based therapy seems to be a promising treatment for acute lung injury, but the therapeutic effects of BMSCs transplantation on acute lung injury induced by brain ischemia and the mechanisms have not been totally elucidated. This study explores the effects of transplantation of BMSCs on acute lung injury induced by focal cerebral ischemia and investigates the underlying mechanism. Acute lung injury model was induced by middle cerebral artery occlusion (MCAO). BMSCs (with concentration of 1 × 106/ml) were transplanted into host through tail vein 1 day after MCAO. Then, the survival, proliferation and migration of BMSCs in lung were observed at 4 days after transplantation, and histology observation and lung function were assessed for 7 days. Meanwhile, in situ hybridization (ISH), qRT-PCR and western blotting were employed to detect the expression of TNF-α in lung. Neurobehavioral deficits and acute lung injury could be seen in brain ischemia rats. Implanted
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged with MHC class I mAb. In this study, when mice housed in a rodent, specific pathogen-free barrier room were challenged with MHC I mAb, there was significant protection from TRALI compared with nonbarrier mice. Priming mice with LPS restored lung injury with mAb challenge. Using TLR4-deficient bone marrow chimeras, the priming phenotype was restricted to animals with WT hematopoietic cells, and depletion of either neutrophils or platelets was protective. Both neutrophils and platelets were sequestered in the lungs of mice with TRALI, and retention of platelets was neutrophil dependent. Interestingly, treatment with aspirin prevented lung injury and mortality, but blocking the P selectin or CD11b/CD18 pathways did not. These data suggest a 2-step mechanism of TRALI: ...
TY - JOUR. T1 - Towards prevention of acute lung injury. T2 - Frequency and outcomes of emergency department patients at-risk - A multicenter cohort study. AU - Hou, Peter C.. AU - Elie-Turenne, Marie Carmelle. AU - Mitani, Aya. AU - Barry, Jonathan M.. AU - Kao, Erica Y.. AU - Cohen, Jason E.. AU - Frendl, Gyorgy. AU - Gajic, Ognjen. AU - Gentile, Nina T.. N1 - Funding Information: The STAR Center provided internal funding (Dr. Frendl), research staff, and biostatistical support, Brigham and Womens Hospital, Boston, MA. Dr. Gajic is supported in part by grants from the National Heart, Lung, and Blood Institute HL78743-01A1; National Center for Research Resources 1 KL2 RR024151. Dr. Gentile is supported in part by grants from the National Institute of Neurological Disorders and Stroke 5U10NS059039-04. The rest of the authors have no disclosures or conflict of interest.. PY - 2012/12. Y1 - 2012/12. N2 - Background: Few emergency department (ED) evaluations on acute lung injury (ALI) have been ...
Because experimental studies have shown that intact alveolar epithelial fluid transport function is critical for resolution of pulmonary edema and acute lung injury, we measured net alveolar fluid clearance in 79 patients with acute lung injury or the acute respiratory distress syndrome. Pulmonary e …
TY - JOUR. T1 - N-acetylcysteine abrogates acute lung injury induced by endotoxin. AU - Kao, Shang Jyh. AU - Wang, David. AU - Lin, Hen I.. AU - Chen, Hsing I.. PY - 2006/1. Y1 - 2006/1. N2 - 1. Acute lung injury (ALI) or acute respiratory distress syndrome is a serious clinical problem with high mortality. N-Acetylcysteine (NAC) is an anti-oxidant and a free radical scavenger. It has been reporeted recently that NAC ameliorates organ damage induced by endotoxin (lipopolysaccharide; LPS) in conscious rats. The present study was designed to evaluate the effects of NAC on LPS-induced ALI and other changes in anaesthetized rats. 2. Sprague-Dawley rats were anaesthetized with pentobarbital (40 mg/kg, i.p.). Endotracheal intubation was performed to provide artificial ventilation. Arterial pressure and heart rate were monitored. The extent of ALI was evaluated with the lung weight (LW)/bodyweight ratio, LW gain, exhaled nitric oxide (NO) and protein concentration in bronchoalveolar lavage (PCBAL). ...
Aim To investigate the role of inhibition of the PTEN in LPS-induced acute lung injury.Methods Tirty-two male SD rats were divided into LPS group and phen + LPS group(n = 16 each),then the mortality of rats in two groups was compared.Another sixty male SD rats were divided into four groups randomly:control group(n = 6),LPS group(n = 24),phen + LPS group(n = 24),phen group(n = 6).Both LPS group and phen + LPS group were subjected to 1,3,6 h and 12 h time point subgroups after LPS administration(n = 6 each).The concentrations of protein,tumor necrosis factor-α(TNF-α) andinterleukin-6(IL-6) inbronch-oalveolar lavage fluids(BALF) were detected.The histopathologic changes of lung tissues,and the expression of p-Akt in lung tissues were also observed.Results Phen pretreatment significantly decreased the LPS-induced lethality(P 0.05).In LPS group,the protein and cytokines in BALF were significantly increased(P 0.05) and the lung tissues showed obviously inflammatory responses under light microscopy
Previous randomized trials failed to demonstrate a decrease in mortality of patients with acute lung injury treated by exogenous surfactant. The aim of this prospective randomized study was to evaluate the effects of exogenous porcine-derived surfactant on pulmonary reaeration and lung tissue in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). Twenty patients with ALI/ARDS were studied (10 treated by surfactant and 10 controls) in whom a spiral thoracic computed tomography scan was acquired before (baseline), 39 hours and 7 days after the first surfactant administration. In the surfactant group, 3 doses of porcine-derived lung surfactant (200 mg/kg/dose) were instilled in both lungs at 0, 12 and 36 hours. Each instillation was followed by recruitment maneuvers. Gas and tissue volumes were measured separately in poorly/nonaerated and normally aerated lung areas before and seven days after the first surfactant administration. Surfactant-induced lung reaeration was
TY - JOUR. T1 - Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. AU - Festic, Emir. AU - Ortiz-Diaz, Enrique. AU - Lee, Augustine. AU - Li, Guangxi. AU - Kor, Daryl J.. AU - Adebola, Adesanya. AU - Akca, Ozan. AU - Hoth, Jason. AU - Levitt, Joseph E.. AU - Carter, Rickey. AU - Gajic, Ognjen. N1 - Funding Information: The work was supported in part by HL78743-01A1 , 1 KL2 RR024151 , and the Mayo Clinic Critical Care Research Committee . PY - 2013/12. Y1 - 2013/12. N2 - Purpose: Inhaled corticosteroids (ICSs) attenuated lung injury in animal studies. We investigated the association between prehospital ICS and incidence of acute lung injury (ALI) among patients at risk. Methods: In this ancillary analysis of the large multicenter Lung Injury Prediction Study cohort, we developed a propensity score for prehospital ICS use followed by matching, for all patients and for a subgroup of patients with at least 1 risk factor for direct pulmonary injury. The ...
https://doi.org/10.18632/oncotarget.20298 Kangfeng Jiang, Tao Zhang, Nannan Yin, Xiaofei Ma, Gan Zhao, Haichong Wu, Changwei Qiu, Ganzhen Deng
Linköping University, Department of Clinical and Experimental Medicine, Transfusion Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine. ...
The British Society for Haematology is registered in England and Wales as a Company Limited by Guarantee, No 2645706 and as a Charity, No 1005735 Registered Office and correspondence address: 100 White Lion Street London N1 9PF. Phone: 020 7713 0990 ...
Intravenous literature: Kleinman, S., Grossman, B. and Kopko, P. (2010). A national survey of transfusion-related acute lung injury risk reduction policies for platelets and plasma in the United States. Transfusion. [epub ahead of print] Abstract: BACKGROUND: Little information exists on the specific transfusion-related acute lung injury (TRALI) risk reduction practices used by multiple blood collecting…
Acute lung injury, a common condition characterized by acute severe hypoxia without evidence of hydrostatic pulmonary edema, remains a key source of mortality and morbidity in critically ill patients. The condition has a high incidence rate across the globe and overall rate of mortality remains high. Pathogenesis of the condition is explained by injuries to both the alveolar and endothelium epithelium. Recent advances in the field have helped researchers gain a better understanding of pathophysiology of the condition and several biological markers associated with worse clinical outcomes have been identified. Ongoing research in the area of fluid conservation and lung-protective ventilation strategies have demonstrated improvements in survival rate of patients. Potential treatment methods such as statin therapy and nutritional strategies are also expected to gain more focus from research bodies operating in the area of treatment of acute lung injury.. Request a sample copy of the Report @ ...
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are the leading causes of death in critical care. (LPS group) and the additional 18 rats received PFC through femoral vein prior to LPS instillation (LPS+PFC group). The rats in the control group were sacrificed 6 hours later on after saline instillation. At 2, 4 and 6 hours of exposure to LPS, 6 rats in the LPS group and 6 rats in LPS+PFC group were sacrificed at each time point. By analyzing pulmonary pathology, partial pressure of oxygen in the blood (PaO2) and lung wet-dry excess weight ratio (W/D) of each rat, we found that intravenous infusion of PFC significantly alleviated acute lung injury induced by LPS. Moreover, we BEZ235 novel inhibtior showed that the manifestation of pulmonary myeloperoxidase (MPO), intercellular adhesion molecule-1 (ICAM-1) of endothelial cells and CD11b of polymorphonuclear neutrophils (PMN) induced by LPS were significantly decreased by PFC treatment reported that ...
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Objective:Although ventilation with small tidal volumes is recommended in patients with established acute lung injury, most others receive highly variable tidal volume aimed in part at normalizing arterial blood gas values. We tested the hypothesis that acute lung injury, which develops after the in
The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There are currently no specific treatment strategies for avian influenza. We hypothesized that mesenchymal stromal cells (MSCs) would have beneficial effects in the treatment of H9N2 AIV-induced acute lung injury in mice. Six- to 8-week-old C57BL/6 mice were infected intranasally with 1 × 104 MID50 of A/HONG KONG/2108/2003 [H9N2 (HK)] H9N2 virus to induce acute lung injury. After 30 min, syngeneic MSCs were delivered through the caudal vein. Three days after infection, we measured the survival rate, lung weight, arterial blood gas, and cytokines in both bronchoalveolar lavage fluid (BALF) and serum, and assessed pathological changes to
The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There are currently no specific treatment strategies for avian influenza. We hypothesized that mesenchymal stromal cells (MSCs) would have beneficial effects in the treatment of H9N2 AIV-induced acute lung injury in mice. Six- to 8-week-old C57BL/6 mice were infected intranasally with 1 × 104 MID50 of A/HONG KONG/2108/2003 [H9N2 (HK)] H9N2 virus to induce acute lung injury. After 30 min, syngeneic MSCs were delivered through the caudal vein. Three days after infection, we measured the survival rate, lung weight, arterial blood gas, and cytokines in both bronchoalveolar lavage fluid (BALF) and serum, and assessed pathological changes to
TY - JOUR. T1 - Passive targeting of phosphatiosomes increases rolipram delivery to the lungs for treatment of acute lung injury. T2 - An animal study. AU - Fang, Chia Lang. AU - Wen, Chih Jen. AU - Aljuffali, Ibrahim A.. AU - Sung, Calvin T.. AU - Huang, Chun Lin. AU - Fang, Jia You. PY - 2015/7/10. Y1 - 2015/7/10. N2 - A novel nanovesicle carrier, phosphatiosomes, was developed to enhance the targeting efficiency of phosphodiesterase 4 (PDE4) inhibitor to the lungs for treating acute lung injury (ALI) by intravenous administration. Phosphatiosomes were the basis of a niosomal system containing phosphatidylcholine (PC) and distearoylphosphatidylethanolamine polyethylene glycol (DSPE-PEG). Rolipram was used as the model drug loaded in the phosphatiosomes. Bioimaging, biodistribution, activated neutrophil inhibition, and ALI treatment were performed to evaluate the feasibility of phosphatiosomes as the lung-targeting carriers. An encapsulation percentage of , 90% was achieved for rolipram-loaded ...
Stephen M. Black and a team of researchers have uncovered information that could help with treatment for acute lung injury. A summary of their study recently appeared in The Journal of Biological Chemistry, where they noted that a bacterial infection can throw off the equilibrium of two key proteins in the lungs and also put patients at risk of a highly lethal acute lung injury (ALI).. As Stephen M. Black explained in a recent press release, Bacteria can alter a single amino acid in the protein RhoA, pushing its activity level well above that of Rac1 and prompting blood vessels to leak and flood thousands of tiny air sacs in the lungs. Fortunately there might be a biological shield that is able to protect RhoA from potentially lethal alterations.. Stephen M. Black compared activation of RhoA to a rapid-fire gun that does not require the operator to pause and reload. As he explained, Activation of RhoA is an early, early event and it is a pathological activation. The cell cannot regulate it ...
TY - JOUR. T1 - Acute lung injury and nutritional support. AU - Gasperino, James. AU - Kvetan, Vladimir. PY - 2006/4/1. Y1 - 2006/4/1. KW - Acute lung injury. KW - Anti-oxidants. KW - Enteral feeding. KW - Fish oil. KW - Mechanical ventilation. UR - http://www.scopus.com/inward/record.url?scp=33645802011&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33645802011&partnerID=8YFLogxK. U2 - 10.1097/01.CCM.0000208328.77128.C1. DO - 10.1097/01.CCM.0000208328.77128.C1. M3 - Editorial. C2 - 16550085. AN - SCOPUS:33645802011. VL - 34. SP - 1265. EP - 1267. JO - Critical Care Medicine. JF - Critical Care Medicine. SN - 0090-3493. IS - 4. ER - ...
(Health-NewsWire.Net, March 24, 2020 ) Market Overview The Global Acute Lung Injury Market is expected to grow at a CAGR of 5.8% during the forecasting period (2019-2026). Acute lung injury is a severe condition caused by acute hypoxemic respiratory failure. It is a crucial source of mortality a
Press Release issued May 28, 2014: Reportstack, provider of premium market research reports announces the addition of Acute Lung Injury - Pipeline Review, H1 2014 market report to its offering Acute Lung Injury - Pipeline Review, H1 2014
Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell infiltration, activation and inflammatory cytokine release, enhancing basal alveolar fluid clearance and improving alveolar capillary barrier function.The Beta Agonist Lung Injury TrIal (prevention) is a multi-centre, randomised, double blind, placebo-controlled trial. The aim of the trial is to determine in patients undergoing elective transthoracic oesphagectomy, if treatment with inhaled salmeterol 100 mcg twice daily started at induction of anaesthesia and continued for 72 hours thereafter compared to placebo affect the incidence of early acute lung injury and other clinical, resource and patient focused outcomes. The primary outcome will be the development of acute lung injury within 72 hours of oesophagectomy. The trial secondary outcomes are the development of acute
Thomas Walker, Amy S. Tidwell, Elizabeth A. Rozanski, et al. Veterinary Radiology & Ultrasound 2005;46:300-303. A 5-year-old neutered male mixed breed dog
TY - JOUR. T1 - Transfusion-related acute lung injury following random donor platelet transfusion. T2 - A report of two cases. AU - Ramanathan, Ramesh K.. AU - Triulzi, Darrell J.. AU - Logan, Theodore F.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Objectives: Transfusion-related acute lung injury (TRALI) following random donor platelet (RDP) transfusion is a rare complication of transfusion without any well-documented case reported in the English language literature. We describe 2 patients in whom TRALI occurred following RDP transfusion. Methods: Conventional clinical and laboratory methods. Results: Both patients developed acute shortness of breath 30-60 min after completion of RDP transfusion and required mechanical ventilatory support. Chest X-ray (CXR) in both cases revealed bilateral pulmonary infiltrates. Patient 1 required vasopressors for hypotension. Right heart catheterization ruled out fluid overload. Patient 2 remained hemodynamically stable. Both patients improved rapidly with continued ...
ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, which leads to low blood oxygen levels and respiratory failure. Common causes include pneumonia, septic shock, and lung trauma. Symptoms usually develop within 24 to 48 hours of the original injury or illness, and most patients require immediate care in an intensive care unit (ICU). The main form of treatment for ALI/ARDS is the delivery of oxygen and a continuous level of pressure to the damaged lungs through mechanical ventilation. Past research has shown that lower tidal volume ventilation (LTVV), a protective ventilator management technique in which lower volumes of oxygen are administered, improves short-term clinical outcomes in individuals with ALI/ARDS. However, the long-term impact of LTVV remains unknown. The purpose of this study is to evaluate the effects of LTVV on long-term outcomes in individuals with ALI/ARDS.. This study will enroll individuals admitted to an ...
ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, which leads to low blood oxygen levels and respiratory failure. Common causes include pneumonia, septic shock, and lung trauma. Symptoms usually develop within 24 to 48 hours of the original injury or illness, and most patients require immediate care in an intensive care unit (ICU). The main form of treatment for ALI/ARDS is the delivery of oxygen and a continuous level of pressure to the damaged lungs through mechanical ventilation. Past research has shown that lower tidal volume ventilation (LTVV), a protective ventilator management technique in which lower volumes of oxygen are administered, improves short-term clinical outcomes in individuals with ALI/ARDS. However, the long-term impact of LTVV remains unknown. The purpose of this study is to evaluate the effects of LTVV on long-term outcomes in individuals with ALI/ARDS.. This study will enroll individuals admitted to an ...
An attempt to validate the modification of the American-European consensus definition of acute lung injury/acute respiratory distress syndrome by the Berlin definition in a university hospital ...
Transfusion-related acute lung injury (TRALI) is defined as noncardiogenic pulmonary edema temporally related to the transfusion of blood products. We present a patient who, while undergoing orthotopic liver transplantation, developed acute pulmonary edema within minutes of administration of fresh frozen plasma (FFP).
References 1. Ashbaugh DG, Bigelow DB, Petty TL et al. Acute Respiratory Distress in Adults. Lancet. 1967; 2: 319-3232. Murray JF, Matthay MA, Luce JM et al. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988; 138: 720-7233. Bernard GR, Artigas A, Brigham KL et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes and clinical trial coordination. Am. J. Respir. Crit. Care Med. 1994 Mar; 149 (3 Pt 1): 818-8244. Rubenfeld GD, Herridge MS. Epidemiology and Outcomes of Acute Lung Injury. Chest. 2007; 131 (2): 554-5625. McCallum NS, Evans TW. Epidemiology of Acute Lung Injury. Current Opinion in Critical Care. 2005: 11; 43-496. Rubenfeld GD, Caldwell E, Peabody E et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353: 1685-16937. Finney SJ, Evans TW. Acute lung injury outside the ICU: a significant problem. Critical Care. 2007; 11: 1698. Hudson LD, Milberg JA, Anardi D et al. Clinical risks for ...
The main pathogenesis of acute lung injury induced by haemorrhagic shock is inflammation. BML-111, a lipoxinA(4)-receptor agonist, promotes acute inflammatory resolution. We sought to elucidate whether BML-111 protects haemorrhagic shock-induced acute lung injury in rats. Thirty two adult male rats were randomized to sham group (sham), haemorrhagic shock/resuscitation (HS), HS plus BML-111 (BML-111), and HS plus BML-111 and BOC-2 (BOC-2). Haemorrhagic shock was induced by blood drawing, and then resuscitation was obtained by infusion of shed blood and two-fold volume saline. Histological findings, as well as assays of neutrophilic infiltration (myeloperoxidase activity, ICAM-1 expression), inflammatory cytokines and pro-inflammatory factor (IκB-α and NF-κB p65) confirmed that haemorrhagic shock induced acute lung injury. BML-111 significantly mitigated acute lung injury induced by haemorrhagic shock. However, BOC-2, an antagonist of the lipoxinA(4)-receptor, partially reversed the protective ...
1. Gervais HW, Eberle B, Konietzke D, Hennes HJ, Dick W, Comparison of blood gases of ventilated patients during transport. Critical Care Medicine 1987;15:761-763.. 2. Weiss, Steven J., et al. Automatic Transport Ventilator Versus Bag Valve In The EMS Setting: A Prospective, Randomized Trial. Southern Medical Journal 98.10 (2005): 970-976.. 3. Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med. 2013 Nov 28;369(22):2126-36.. 4. Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, Protti A, Gotti M, Chiurazzi C, Carlesso E, Chiumello D, Quintel M. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med. 2016 Oct;42(10):1567-75.. 5. The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000, 342:1301-1308.. 6. Putensen C, Theuerkauf N, Zinserling J, Wrigge H, Pelosi P. ...
Pseudomonas aeruginosa is the most common gram-negative pathogen causing pneumonia in immunocompromised patients. Acute lung injury induced by bacterial exoproducts is associated with a poor outcome in P. aeruginosa pneumonia. The major pathogenic toxins among the exoproducts of P. aeruginosa and the mechanism by which they cause acute lung injury have been investigated: exoenzyme S and co-regulated toxins were found to contribute to acute lung injury. P. aeruginosa secretes these toxins through the recently defined type III secretion system (TTSS), by which gram-negative bacteria directly translocate toxins into the cytosol of target eukaryotic cells. TTSS comprises the secretion apparatus (termed the injectisome), translocators, secreted toxins, and regulatory components. In the P. aeruginosa genome, a pathogenic gene cluster, the exoenzyme S regulon, encodes genes underlying the regulation, secretion, and translocation of TTSS. Four type III secretory toxins, namely ExoS, ExoT, ExoU, and ...
This study by the Acute Respiratory Distress Syndrome Network supports the use of low tidal volumes in acute lung injury and ARDS, and is consistent with a previous trial.1 It differs from 3 previous negative trials2-4 by having a larger difference in tidal volumes between groups, and by having a more aggressive approach to correcting acidosis. This study provides important information about tidal volume size; however, further research is still needed to determine the importance of concurrent strategies such as positive end expiratory pressure (PEEP).. In this study, an equation based on sex and height was used to calculate a predicted body weight, which was then used to set tidal volumes. Obesity is a common problem; the use of measured body weight can inadvertently lead to the use of high tidal volume ventilation. Tidal volumes should be based on ideal versus measured body weight.. This information is relevant to nurses who care for mechanically ventilated patients. Through continuous ...
The aim of present study was to evaluate the protective effects of dexmedetomidine (DEX) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its possible mechanisms mediated by HMGB1. In vivo, pulmonary pathology observation and myeloperoxidase (MPO) activity were also examined to evaluate the protective effect of DEX in the lungs. Tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in bronchoalveolar lavage fluid (BALF), serum and lung tissues LPS-induced rats were detected. The oxidative indices including superoxide dismutase (SOD), Malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) in serum were also determined. Additionally, nitric oxide (NO), TNF-α, IL-6 and IL-1β, MDA, SOD and GSH-Px in the supernatants of LPS-induced BEAS-2B cells were measured. Furthermore, we detected the protein expression of high mobility group box-1 protein (HMGB1), Toll-like receptor 4 (TLR4), myeloid differentiating factor 88 (MyD88), inhibitor of ...
TY - CHAP. T1 - ROS signaling in the pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). AU - Kellner, Manuela. AU - Noonepalle, Satish. AU - Lu, Qing. AU - Srivastava, Anup. AU - Zemskov, Evgeny. AU - Black, Stephen M.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the excessive generation of oxygen radicals under pathological conditions such as acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) leads to increased endothelial permeability. Within this hallmark of ALI and ARDS, vascular microvessels lose their junctional integrity and show increased myosin contractions that promote the migration of polymorphonuclear leukocytes (PMNs) and the transition of solutes and fluids in the alveolar lumen. These processes all have a redox component, and this chapter focuses on the role played ...
TY - JOUR. T1 - Acute lung injury. T2 - A clinical and molecular review. AU - Butt, Yasmeen. AU - Kurdowska, Anna. AU - Allen, Timothy Craig. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2016/4. Y1 - 2016/4. N2 - Context.-Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are a continuum of lung changes arising from a wide variety of lung injuries, frequently resulting in significant morbidity and frequently in death. Research regarding the molecular pathophysiology of ALI/ ARDS is ongoing, with the aim toward developing prognostic molecular biomarkers and molecular-based therapy. Objective.-To review the clinical, radiologic, and pathologic features of ALI/ARDS; and the molecular pathophysiology of ALI/ARDS, with consideration of possible predictive/prognostic molecular biomarkers and possible molecular-based therapies. Data Sources.-Examination of the English-language medical literature regarding ALI and ARDS. Conclusions.-ARDS is primarily a ...
Although the etiology of TRALI has not been fully delineated, two hypotheses have been postulated. The antibody-mediated hypothesis proposes that antibodies react with a corresponding antigen triggering capillary leak. Identified antibodies include antibodies to human leukocyte antigen (HLA) class I and II antigens and human neutrophil antigen (HNA). In this hypothesis, antibodies bind to recipient neutrophils. The antibody bound neutrophils are then sequestered in the lungs where activation of complement results in endothelial damage, capillary leak, and ALI. In most of these cases, the antibody is found in the donor with the corresponding antigen identified on the recipients neutrophils. Most donors associated with cases of TRALI are multiparous women who become alloimmunized during pregnancy. One notable case supporting the antibody mediated hypothesis describes a patient who underwent lung transplantation and developed dyspnea and hypoxia after receiving a transfusion of two units of packed ...
TY - JOUR. T1 - Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. AU - Khan, Samina Yasmin. AU - Kelher, Marguerite R.. AU - Heal, Joanna M.. AU - Blumberg, Neil. AU - Boshkov, Lynn K.. AU - Phipps, Richard. AU - Gettings, Kelly F.. AU - McLaughlin, Nathan J.. AU - Silliman, Christopher C.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Transfusion-related acute lung injury (TRALI) is a form of posttransfusion acute pulmonary insufficiency that has been linked to the infusion of biologic response modifiers (BRMs), including antileukocyte antibodies and lipids. Soluble CD40 ligand (sCD40L) is a platelet-derived proinflammatory mediator that accumulates during platelet storage. We hypothesized that human polymorphonuclear leukocytes (PMNs) express CD40, CD40 ligation rapidly primes PMNs, and sCD40L induces ...
TY - JOUR. T1 - Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. AU - Arcaroli, John J.. AU - Hokanson, John E.. AU - Abraham, Edward. AU - Geraci, Mark. AU - Murphy, James R.. AU - Bowler, Russell P.. AU - Dinarello, Charles A.. AU - Silveira, Lori. AU - Sankoff, Jeff. AU - Heyland, Daren. AU - Wischmeyer, Paul. AU - Crapo, James D.. PY - 2009/1/15. Y1 - 2009/1/15. N2 - Rationale: Extracellular superoxide dismutase (EC-SOD) is a potent antioxidant that plays an important role in controlling oxidant-mediated stress and inflammation. High levels of EC-SOD are found in the lung. Acute lung injury (ALI) frequently occurs in patients with infection, and levels of EC-SOD have been shown to modulate severity of lung injury in transgenic animal models of endotoxemia-induced ALI. An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart ...
TY - JOUR. T1 - An alternative method of acute lung injury classification for use in observational studies. AU - Shah, Chirag V.. AU - Lanken, Paul N.. AU - Localio, A. Russell. AU - Gallop, Robert. AU - Bellamy, Scarlett. AU - Ma, Shwu Fan. AU - Flores, Carlos. AU - Kahn, Jeremy M.. AU - Finkel, Barbara. AU - Fuchs, Barry D.. AU - Garcia, Joe G.N.. AU - Christie, Jason D.. N1 - Funding Information: Funding/Support: This work was supported by the National Institutes of Health [Grants P50HL60290, HL079063, T32 HL07891 ] and EMER07/001 . PY - 2010/11/1. Y1 - 2010/11/1. N2 - Background: In observational studies using acute lung injury (ALI) as an outcome, a spectrum of lung injury and difficult-to-interpret chest radiographs (CXRs) may hamper efforts to uncover risk factor associations. We assessed the impact of excluding patients with difficult-to-classify or equivocal ALI diagnosis on clinical and genetic risk factor associations for ALI after trauma. Methods: This study was of a prospective ...
This study was accepted to be presented for an award at the 25th Argentine Congress of Intensive Therapy. In December, 2015, this study received the 2015 Award for Best Scientific Study from the Sanatorio Anchorena Teaching and Research Committee. Conflict of interest: The authors declare that there is no conflict of interest associated with this publication. Bibliography 1. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308. 2. Protti A, Cressoni M, Santini A, et al. Lung stress and strain during mechanical ventilation: any safe threshold? Am J Respir Crit Care Med 2011; 183: 1354-1362. 3. Brochard L, Rauss A, Benito S, et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 1994; 150: 896-903. 4. Esteban A, Frutos F, ...
Biphasic positive airway pressure (BIVENT) is a partial support mode that employs pressure-controlled, time-cycled ventilation set at two levels of continuous positive airway pressure with unrestricted spontaneous breathing. BIVENT can modulate inspiratory effort by modifying the frequency of controlled breaths. Nevertheless, the optimal amount of inspiratory effort to improve respiratory function while minimizing ventilator-associated lung injury during partial ventilatory assistance has not been determined. Furthermore, it is unclear whether the effects of partial ventilatory support depend on acute lung injury (ALI) etiology. This study aimed to investigate the impact of spontaneous and time-cycled control breaths during BIVENT on the lung and diaphragm in experimental pulmonary (p) and extrapulmonary (exp) ALI. This was a prospective, randomized, controlled experimental study of 60 adult male Wistar rats. Mild ALI was induced by Escherichia coli lipopolysaccharide either intratracheally (ALIp) or
TY - JOUR. T1 - Functional genomic assessment of phosgene-induced acute lung injury in mice. AU - Leikauf, George D.. AU - Concel, Vincent J.. AU - Bein, Kiflai. AU - Liu, Pengyuan. AU - Berndt, Annerose. AU - Martin, Timothy M.. AU - Ganguly, Koustav. AU - Jang, An Soo. AU - Brant, Kelly A.. AU - Dopico, Richard A.. AU - Upadhyay, Swapna. AU - Cario, Clinton. AU - Peter Di, Y. P.. AU - Vuga, Louis J.. AU - Kostem, Emrah. AU - Eskin, Eleazar. AU - You, Ming. AU - Kaminski, Naftali. AU - Prows, Daniel R.. AU - Knoell, Daren L.. AU - Fabisiak, James P.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - In this study, a genetically diverse panel of 43 mouse strains was exposed to phosgene and genome-wide association mapping performed using a high-density single nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was also used to improve the genetic resolution in the identification of genetic determinants of phosgene-induced acute lung injury (ALI). We prioritized the identified genes based on whether ...
Dive into the research topics of ROS signaling in the pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). Together they form a unique fingerprint. ...
Authors: Wang, Bing , Wu, Bin , Ran, Yan-Ni Article Type: Research Article Abstract: OBJECTIVE: This study aims to explore whether positive end-expiratory pressure (PEEP) guided by esophageal pressure is better than the acute respiratory distress syndrome network (ARDSNet) during the treatment of traumatic acute respiratory distress syndrome (ARDS) patients. SUGGESTIONS: The use of the oxygenation method of inhaled oxygen concentration titration PEEP is suggested. METHODS: This study takes traumatic ARDS patients as the research object. The data of 23 patients were included in this study. The patients were randomly divided into two groups: the esophageal pressure titration PEEP group (n = …12), and the ARDSNet (PEEP-FiO 2 table) titration PEEP group (n = 11). All patients were given mechanical ventilation, and changes in oxygenation index, respiratory mechanics, hemodynamics and inflammatory reaction index were recorded when titrating the best PEEP with the two methods on the current day of ...
ARDSNET STUDY PDF - Low tidal volume, low pressure. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal.
ARDSNET STUDY PDF - Low tidal volume, low pressure. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal.
Treatment of acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), remain unsolved problems of intensive care medicine. ALI/ARDS are characterized by lung edema due to increased permeability of the alveolar-capillary barrier and subsequent impairment of arterial oxygenation. Lung edema, endothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and broncheoalveolar space. Hence, activation and recruitment of neutrophils are regarded to play a key role in progression of ALI/ARDS. Neutrophils are the first cells to be recruited to the site of inflammation and have a potent antimicrobial armour that includes oxidants, proteinases and cationic peptides. Under pathological circumstances, however, unregulated release of these microbicidal compounds into the extracellular space paradoxically can damage host tissues. This review focuses on the mechanisms of neutrophil recruitment into the lung and on the contribution of neutrophils
The overall aim of the present thesis was to study aspects of patient safety in critically ill patients with special focus on airway management, respiratory complications and nursing procedures. Study I describes a method called pharyngeal oxygen administration during intubation in an experimental acute lung injury model. The study showed that pharyngeal oxygenation prevented or considerably increased the time to life-threatening hypoxemia at shunt fractions by at least up to 25% and that this technique could be implemented in airway algorithms for the intubation of hypoxemic patients. In study II, we investigated short-term disconnection of the expiratory circuit from the ventilator during filter exchange in critically ill patients. We demonstrated that when using pressure modes in the ventilator, there was no indication of any significant deterioration in the patients lung function. A bench test suggests that this result is explained by auto-triggering with high inspiratory flows during the ...
Today we will be discussing TRALI, or transfusion-related acute lung injury. TRALI accounts for almost half of all transfusion-related fatalities in the United States.. Although several mechanisms exist, one of the major causes of TRALI is donor antibodies to white blood cells, such as human leukocyte antigen and human neutrophil antigen, or commonly referred to as HLA and HNA.. Dr. AuBuchon who wrote an editorial in TRANSFUSION comments:. Blood collectors in the United States have taken steps over the last half-dozen years to reduce the risk of TRALI through plasma, and, in many cases, also apheresis platelets. This has primarily involved women who have previously been pregnant, either deferring the use of their plasma or testing them to identify those lacking HLA antibodies. These steps have resulted in a reduction of TRALI risk by about three-quarters.. Dr. Vandekerckhove and his colleagues in Belgium screened 77 male plateletpheresis donors with a history of transfusions and 942 female ...
Background: Acute lung injury is an important cause of respiratory failure in the critically ill patient. It is caused by damage to the alveolar barrier with subsequent alveolar flooding leading to the development of refractory hypoxaemia. beta Agonists stimulate alveolar fluid clearance in animal models of lung injury. In a clinical trial (BALTI-1), intravenous beta agonists reduced extravascular lung water, an effect that took 72 h in contrast with what animal studies suggest. One possible explanation for the delay in change in extravascular lung water is the time required for salbutamol to stimulate alveolar epithelial repair ...
Research outputs, collaborations and relationships for Acute Lung Injury (ALI) / Adult Respiratory Distress Syndrome (ARDS) Center of Excellence, Pitt published between 1 June 2019 - 31 May 2020 as tracked by the Nature Index.
TY - JOUR. T1 - Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. AU - Jacobson, Jeffrey R.. AU - Barnard, Joseph W.. AU - Grigoryev, Dmitry N.. AU - Ma, Shwu Fan. AU - Tuder, Rubin M.. AU - Garcia, Joe G N. PY - 2005/6. Y1 - 2005/6. N2 - Therapies to limit the life-threatening vascular leak observed in patients with acute lung injury (ALI) are currently lacking. We explored the effect of simvastatin, a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor that mediates endothelial cell barrier protection in vitro, in a murine inflammatory model of ALL C57BL/6J mice were treated with simvastatin (5 or 20 mg/kg body wt via intraperitoneal injection) 24 h before and again concomitantly with intratracheally administered LPS (2 μg/g body wt). Inflammatory indexes [bronchoalveolar lavage (BAL) myeloperoxidase activity and total neutrophil counts assessed at 24 h with histological confirmation] were markedly increased after LPS alone but significantly ...
Acute lung injury (ALI) is a prevalent and devastating condition in the intensive care unit. Although pulmonary artery catheters (PAC) provide clinicians with important data about a patients haemodynamic status, doubts about their clinical benefit and worries about safety have raised questions about their usefulness. This study was designed to address this issue, with 1000 patients recruited in 20 North American centres. Patients were recruited after being diagnosed with ALI and were managed haemodynamically according to a standardised management protocol. 513 patients were randomised to have a PAC and 487 to have a standard central venous catheter (CVC).. Both the PAC and CVC groups had similar rates of death during the first 60 days (27.4% and 26.3% respectively, p = 0.69). Mean (SE) ventilator-free days were also similar (13.2 (0.5) and 13.5 (0.5), p = 0.58), as were the number of days not spent in the intensive care unit up to day 28 (12.0 (0.4) and 12.5 (0.5), p = 0.40). Using a PAC did ...
Acute respiratory distress syndrome (ARDS) is a life threatening respiratory failure due to lung injury from a variety of precipitants. Pathologically ARDS is characterised by diffuse alveolar damage, alveolar capillary leakage, and protein rich pulmonary oedema leading to the clinical manifestation of poor lung compliance, severe hypoxaemia, and bilateral infiltrates on chest radiograph. Several aetiological factors associated with the development of ARDS are identified with sepsis, pneumonia, and trauma with multiple transfusions accounting for most cases. Despite the absence of a robust diagnostic definition, extensive epidemiological investigations suggest ARDS remains a significant health burden with substantial morbidity and mortality. Improvements in outcome following ARDS over the past decade are in part due to improved strategies of mechanical ventilation and advanced support of other failing organs. Optimal treatment involves judicious fluid management, protective lung ventilation with ...
The Acute Lung Injury (ALI) Center of Excellence, under the direction of Rama Mallampalli, MD, is focused on the investigation of fundamental mechanisms underlying the development and repair of lung injury, and the translational and clinical implications. The program utilizes state-of-the-art tools in molecular, biochemical, translational, and clinical investigation. Investigators within the Center are supported by the National Institutes of Health through 12 R01 grants and a Program Project Grant, by the Department of Veterans Affairs with two VA Merit awards, and by several philanthropic societies through seven investigator-initiated grant awards. Collaborative interactions exist with investigators in the Departments of Anesthesiology, Critical Care Medicine, Environmental and Occupational Health, Pathology, and Surgery. In addition to cutting-edge basic and translational science, investigators in the Center are currently establishing and participating in clinical trials with mesenchymal stem ...
Severe trauma, caused by flame burn and smoke (B + S) inhalation induces acute lung injury (ALI) and results in the loss of pulmonary function. A cascade of molecular and cellular events initiates the formation of reactive oxygen/nitrogen species (ROS/RNS) that in turn drives an inflammatory response and consequently cell death through hyper-activation of poly (ADP-ribose) polymerase (PARP-1). The purpose of this study was to investigate and counteract pulmonary dysfunction associated with nitrosative stress generated after B + S inhalation injury in an ovine and murine model of ALI. \r\nIn our time course experiment, sheep were sacrificed at 4, 8, 12, 18 and 24 hours post B + S injury. From 4 through 24 hours, there was a progressive increase in airway obstruction and lung edema formation. Furthermore, injury was associated with increased ROS/RNS generation, pro-inflammatory cytokine expression and neutrophil accumulation. Additionally, PARP-1 enzymatic activity increased in parallel with ...
Transfusion-associated acute lung injury (TRALI) is a syndrome that is similar to Acute respiratory distress syndrome (ARDS), ... "Transfusion-related acute lung injury; clinical perspectives". Korean Journal of Anaesthesiology. 68 (2): 101-105. doi:10.4097/ ... Acute hemolytic reactions are defined according to Serious Hazards of Transfusion (SHOT) as "fever and other symptoms/signs of ... Kidney injury may occur because of the effects of the hemolytic reaction (pigment nephropathy).[29] The severity of the ...
Acute lung injury may also cause pulmonary edema through injury to the vasculature and parenchyma of the lung. Acute lung ... Transfusion associated Acute Lung Injury (TRALI) is a specific type of blood-product transfusion injury that occurs when the ... Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... "Transfusion-related acute lung injury (TRALI)". Professional Education. 2016-06-17. Retrieved 2016-12-03.. ...
... the definition of acute lung injury), or. *arterial partial-pressure of carbon dioxide (PaCO2) , 65 torr (20 mmHg) over ... Lungs: acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory ... Acute renal failure. Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction ... Increased permeability of the lung vessels causes leaking of fluids into alveoli, which results in pulmonary edema and acute ...
Kawabata K, Hagio T, Matsuoka S (September 2002). "The role of neutrophil elastase in acute lung injury". European Journal of ... of neutrophil elastase can lead to disruption of pulmonary barrier showing symptoms corresponding with acute lung injury.[42] ... Neutrophils are recruited to the site of injury within minutes following trauma and are the hallmark of acute inflammation;[11] ... During the beginning (acute) phase of inflammation, particularly as a result of bacterial infection, environmental exposure,[6] ...
A 2006 Awake! highlighted dangers from transfusion-related acute lung injury (TRALI).[94] ... Heart-Lung Machine, a method in which blood is diverted to an artificial heart-lung machine and directed back into the patient. ...
... transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a ... "Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside". Blood Reviews. 29 (1): 51- ... "Antibody-mediated transfusion-related acute lung injury; from discovery to prevention". British Journal of Haematology. 170 (5 ... infections through better skin cleansing procedures and the incidence of life-threatening transfusion-related acute lung injury ...
These gaseous products can cause acute lung injury. Chronic exposure, for example, from the air at swimming pools where ...
In the case of non-allergic acute lung injury, standard or recommended approaches to treatment have not been defined.[10] ... "Chemical Pneumonitis and Acute Lung Injury Caused by Inhalation of Nickel Fumes". Internal Medicine. 50 (18): 2035-8. doi: ... Patients may present with wheezing or crackles in the lungs. They typically have an increased white blood cell count, and urine ... an event which occurs by inhaling metal oxide fumes that injure the lung cells. This is not an allergic reaction, though ...
"Female Plasma May Not Increase Risk for Transfusion-Related Acute Lung Injury". Medscape. October 23, 2007. Retrieved 2011-07- ... because of concerns about transfusion related acute lung injury (TRALI) and female donors who may have higher leukocyte ...
A 2006 Awake! highlighted dangers from transfusion-related acute lung injury (TRALI). Opposition to the Watch Tower doctrines ... Heart-Lung Machine, a method in which blood is diverted to an artificial heart-lung machine and directed back into the patient ...
... especially in the context of ARDS and acute lung injury. This is commonly referred to as lung protective ventilation. There are ... Krishnan JA, Brower RG (2000). "High-frequency ventilation for acute lung injury and ARDS". Chest. 118 (3): 795-807. doi: ... Jet ventilation has been shown to reduce ventilator induced lung injury by as much as 20%. Usage of high-frequency jet ... High frequency ventilation is thought to reduce ventilator-associated lung injury (VALI), ...
Kawabata K, Hagio T, Matsuoka S (September 2002). "The role of neutrophil elastase in acute lung injury". European Journal of ... Moraes TJ, Chow CW, Downey GP (April 2003). "Proteases and lung injury". Critical Care Medicine. 31 (4 Suppl): S189-94. doi: ... acute respiratory distress syndrome, and cystic fibrosis. A recent study shows that patients with CTSG gene polymorphisms have ... ischemic reperfusion injury, and bone metastasis. It is also implicated in a variety of infectious inflammatory diseases, ...
Otrock, Z. K.; Liu, C.; Grossman, B. J. (2017). "Transfusion-related acute lung injury risk mitigation: An update". Vox ... transfusion-related acute lung injury (TRALI), transfusion associated graft versus host disease and febrile non-hemolytic ... management and prevention of transfusion-related acute lung injury: A comprehensive update". Expert Review of Hematology. 12 (9 ... "Home , National Heart, Lung, and Blood Institute (NHLBI)". www.nhlbi.nih.gov. Retrieved 2018-07-25. Breymann, Christian ( ...
Ventilator-associated lung injury, an acute lung injury that develops during mechanical ventilation ... Ventilator-associated pneumonia, a type of lung infection that occurs in people who are on mechanical ventilation ... is a machine designed to provide mechanical ventilation by moving breathable air into and out of the lungs. ...
Brochard LJ (November 2009). "Tidal volume during acute lung injury: let the patient choose?". Intensive Care Medicine. 35 (11 ... As a result, the pressure in the airway drops, causing an inflow of air into the lungs. With NAVA, the electrical activity of ... Del Sorbo L, Slutsky AS (February 2010). "Ventilatory support for acute respiratory failure: new and ongoing pathophysiological ... March 2010). "Neurally adjusted ventilatory assist increases respiratory variability and complexity in acute respiratory ...
TACO and transfusion related acute lung injury (TRALI) are often difficult to distinguish in the acute situation. TACO is ... Popovsky, M. A. (September 2006). "Transfusion-related acute lung injury and transfusion-associated circulatory overload". ISBT ... "Distinguishing between transfusion related acute lung injury and transfusion associated circulatory overload". Current Opinion ... Low albumin Cardiovascular disease Kidney disease Lung disease Severe anemia Age (less than 3 years old and over 60 years old) ...
Ventilator-associated lung injury (VALI) refers to acute lung injury that occurs during mechanical ventilation. It is ... One of the primary complications that presents in patients mechanically ventilated is acute lung injury (ALI)/acute respiratory ... Common specific medical indications for use include: Acute lung injury, including acute respiratory distress syndrome (ARDS) ... "Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory ...
"Long pentraxin 3 in pulmonary infection and acute lung injury". American Journal of Physiology. Lung Cellular and Molecular ... PTX3 behaves as an acute phase response protein, as the blood levels of PTX3, low in normal conditions (about 25 ng/mL in the ... Lee GW, Goodman AR, Lee TH, Vilcek J (October 1994). "Relationship of TSG-14 protein to the pentraxin family of major acute ... is a novel member of the pentaxin family of acute phase proteins". Journal of Immunology. 150 (5): 1804-12. PMID 7679696. Alles ...
"Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury". PLOS Pathogens. 13 (6): ... Absence of the enzyme renders mice more likely to develop severe lung injury and die if they are challenged with intratracheal ... 2018). "LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma". J Exp Med. 215 (9): ... Other studies found that AOAH reduced translocation of stimulatory LPS from the gastrointestinal microbiota to the lung, where ...
"Management of acute lung injury: sharing data between adults and children". Respiratory Care. 56 (9): 1258-68, discussion 1268- ... They practice in acute care facilities, long-term acute care facilities, skilled nursing facilities, assisted-living centers, ... Scientific research also takes place to look for causes and possible treatment in diseases such as asthma and lung cancer. The ... Respiratory therapists are also primary clinicians in conducting tests to measure lung function and teaching people to manage ...
"Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury". The Journal of Clinical ... This effect is seen not only with neutrophils in the blood, but also in various tissues such as the gut, lung, liver, and blood ... specifically in the lung capillaries and liver sinusoids). Intra-vascular NET formation is tightly controlled and is regulated ... "Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke". Stroke. 49 (3): 754- ...
His initial research focused on animal models of acute lung injury. Montaner initially planned on returning to Argentina after ... Montaner, J.G.; Russel, J.; Lawson, L.; Ruedy, J. (1989). "Acute Respiratory Failure Secondary to Pneumocystis Carinii ...
2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. ...
Of people who have survived drowning, almost one-third will experience complications such as acute lung injury (ALI) or acute ... Jin, Faguang; Li, Congcong (5 April 2017). "Seawater-drowning-induced acute lung injury: From molecular mechanisms to potential ... Lung density may be higher than normal, but normal weights are possible after cardiac arrest or vasovagal reflex. The lungs may ... Inhaled fluid can act as an irritant inside the lungs. Even small quantities can cause the extrusion of liquid into the lungs ( ...
2006). "The role of metallothionein in the pathogenesis of acute lung injury". Am. J. Respir. Cell Mol. Biol. 34 (1): 73-82. ...
Amirshahrokhi K, Bohlooli S (October 2013). "Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in ... "Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats". Archives of ... Schoenig G (1968). Acute oral toxicity of sample No. 751, dimethyl sulfone 1 BT No. A6409. Northbrook, Illinois: Industrial BIO ... The study also evaluated an acute 12g dose and found significant improvements in all symptoms except itching eyes and sneezing ...
... airway pressure release ventilation is indicated in patients with acute lung injury, acute respiratory distress syndrome and ... 1991). "Airway pressure release ventilation during acute lung injury: a prospective multicenter trial". Critical Care Medicine ... 2003). "Spontaneous breathing improves lung aeration in oleic acid-induced lung injury". Anesthesiology. 99 (2): 376-84. doi: ... "Long-term effects of two different ventilatory modes on oxygenation in acute lung injury. Comparison of airway pressure release ...
Non-infectious diseases that may result in symptoms similar to those of EVD include acute promyelocytic leukaemia, haemolytic ... but not very much in their lungs.[77] It is believed that this is the reason researchers have observed pig to primate ... The breakdown of endothelial cells leading to blood vessel injury can be attributed to EBOV glycoproteins. This damage occurs ... pigs with EVD get very high ebolavirus concentrations in their lungs, and not their bloodstream.[76] Therefore, pigs with EVD ...
Acute graft-versus-host disease typically occurs in the first 3 months after transplantation and may involve the skin, ... Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of bilirubin, hepatomegaly and fluid ... The injury of the mucosal lining of the mouth and throat is a common regimen-related toxicity following ablative HSCT regimens ... However, it is less effective in rapidly growing acute leukemias.[38] If cancer relapses after HSCT, another transplant can be ...
Physical medicine and rehabilitation (or physiatry) is concerned with functional improvement after injury, illness, or ... These include treatment of acute and chronic illnesses, preventive care and health education for all ages and both sexes. ... lungs, digestive tract, urinary tract, etc.). ... injuries, past infectious diseases or vaccinations, history of ... Sports medicine deals with the treatment and prevention and rehabilitation of sports/exercise injuries such as muscle spasms, ...
Global Initiative for Chronic Obstructive Lung Disease. halaman 1-7.. *^ Craig JA (2012). Ferri's netter patient advisor (ed. ... GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (October 2016). "Global, regional, and national incidence, ... "Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive ... Global Initiative for Chronic Obstructive Lung Disease. halaman 9-17.. *^ Reilly JJ, Silverman EK, Shapiro SD (2011). "Chronic ...
Spinal manipulation may be cost-effective for sub-acute or chronic low back pain but the results for acute low back pain were ... Ndetan HT, Rupert RL, Bae S, Singh KP (February 2009). "Prevalence of musculoskeletal injuries sustained by students while ... the lungs, or the stomach) that subluxation significantly contributes to, the mean response was 62%.[37] A 2008 survey of 6,000 ... There is moderate quality evidence to support the use of SM for the treatment of acute lumbar radiculopathy[101] and acute ...
Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging. ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... brain tumors are second only to acute lymphoblastic leukemia as the most common form of cancer.[8] In Australia, the average ... with about half of metastases coming from lung cancer.[2] Primary brain tumors occur in around 250,000 people a year globally, ...
2004). 1992-2001 Census of fatal occupational injuries (CFOI) Revised data. Washington, DC: U.S. Department of Labor, Bureau of ... Theorell, T.; Hasselhorn, H.; Vingård, E.; Andersson, B. (2000). "Interleukin 6 and cortisol in acute musculoskeletal disorders ... Byssinosis ("brown lung"). *Chalicosis. *Chimney sweeps' carcinoma. *Chronic solvent-induced encephalopathy (CSE) ... Kidd, P., Scharf, T., & Veazie, M. (1996). Linking stress and injury in the farming environment: A secondary analysis. Health ...
However, inhaled A1AT may not reach the elastin fibers in the lung where elastase injury occurs. Further study is currently ... Kushner, Mackiewicz A (1993). The acute phase response: an overview. Acute-phase glycoproteins: molecular biology, biochemistry ... In the acute phase reaction, a further elevation is required to "limit" the damage caused by activated neutrophil granulocytes ... This involves inhaling purified human A1AT into the lungs and trapping the A1AT into the lower respiratory tract. ...
Leach, Richard E. (2009). Acute and Critical Care Medicine at a Glance (ika-2nd (na) edisyon). Wiley-Blackwell. ISBN 1-4051- ... Diffuse parenchymal lung disease : ... 47 tables (ika-[Online-Ausg.] (na) edisyon). Basel: Karger. 2007. pa. 4. ISBN 978-3-8055 ... "WHO Disease and injury country estimates". World Health Organization (WHO). 2004. Nakuha noong 11 November 2009.. ... Vijayan, VK (2009 May). "Parasitic lung infections". Current opinion in pulmonary medicine. 15 (3): 274-82. PMID 19276810.. ...
Acute toxicity occurs over a period of hours or a few days, and is less of a problem than chronic toxicity. ... while the lung and kidneys may also be capable of storage.[20] ... on ethanol-induced mitochondrial injury in rats". Biochemical ... "The acute and chronic toxic effects of vitamin A". The American Journal of Clinical Nutrition. 83 (2): 191-201. PMID 16469975 ...
... the two signature injuries are posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI). These two signature ... Music therapy may provide a means of improving mental health among people with schizophrenia, but its effects in acute ... Singing training has been found to improve lung, speech clarity, and coordination of speech muscles, thus, accelerating ... Neurological impairments following a brain injury can be in the form of apraxia - loss to perform purposeful movements, ...
Many different knee injuries can happen. Three percent of knee injuries are acute traumatic patellar dislocations.[25] Because ... "Injury. 41 (4): 329-334. doi:10.1016/j.injury.2009.08.007.. *^ Ringleb, Stacie I.; Dhakal, Ajaya; Anderson, Claude D.; Bawab, ... as injury to these structures may occur during the injury or during the reduction process.[3] Subsequent imaging studies are ... "Acromioclavicular injury , Radiology Reference Article , Radiopaedia.org". radiopaedia.org. Retrieved 2018-02-21.. ...
Diet Drug Orlistat Linked to Kidney, Pancreas Injuries. Medscape. Medscape News. [2011-04-26]. (原始内容存档于2012-05-10).. ... National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight ... The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk stratification of ... National Heart, Lung, and Blood Institute (NHLBI). Clinical Guidelines on the Identification, Evaluation, and Treatment of ...
If acute radiation exposure occurs in the first ten days following conception, when few cells have formed, it is likely that ... A consolidated lawsuit brought by two thousand Hanford downwinders for personal injury against the contractors that ran Hanford ... lung, colon, and thyroid tissues as the most radiosensitive among women. For example, the FGR 13 has estimated that the ratio ... Some downwinders may have suffered acute exposure due to their involvement in uranium mining and nuclear experimentation.[4] ...
Acute renal failure. Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction ... Lung Protective Ventilator Strategy utilising 5-8 mls/kg tidal volumes for mechanically ventilated patients to avoid volutrauma ...
Jun Chen, Zao C. Xu, Xiao-Ming Xu, Animal Models of Acute Neurological Injuries, Humana Press; 1 edition, ISBN 978-1-60327-184- ... The term also includes oxygen deprivation due to obstructions in the lungs. Choking, strangulation, the crushing of the ... Brain injury may still occur in a TIA lasting only a few minutes. Having a TIA is a risk factor for eventually having a stroke. ... Focal cerebral ischemia - A stroke occurring in a localized area that can either be acute or transient. This may be due to a ...
Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 2009-11-11. Retrieved ... Gross pathology of a lung showing centrilobular emphysema characteristic of smoking. This close-up of the fixed, cut lung ... For those with very severe disease, surgery is sometimes helpful and may include lung transplantation or lung volume-reduction ...
Transfusion-related acute lung injury. *Illness and injuries during spaceflight. Injury severity scoreEdit. The injury severity ... Other injuries from external physical causes, such as radiation poisoning, burn, or frostbite *Radiation-induced lung injury ... Injury from internal causes such as reperfusion injury. By locationEdit. *Wound, an injury in which skin is torn, cut or ... Traumatic injury, a body wound or shock produced by sudden physical collision or movement[9]*Avulsion injury ...
Acute lung injury and alveolar epithelial function. Masui. 57:51-9. Tang PS, Mura M, Seth R, Liu M. (2008) Acute lung injury ... 2007) Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future ... 2010) Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine ... 2008) Animal models of acute lung injury. Am J Physiol. 295:L379-99. Li X, Li S, Zhang M, Li X, Zhang X, Zhang W, Li C. (2010) ...
Brain injury (temporary or permanent). *Decreased muscle tone. This can be caused by drugs or alcohol, or it can be caused by ... The Epstein-Barr virus, for example, is known to be able to dramatically increase the size of lymphoid tissue during acute ... "Lung. 192 (1): 175-184. doi:10.1007/s00408-013-9511-3. PMC 4216726. PMID 24077936.. ... The permanent premature muscular tonal loss in the upper airway may be precipitated by traumatic brain injury, neuromuscular ...
Acute response[edit]. For individuals not previously exposed to OC effects, the general feelings after being sprayed can be ... It inflames the mucous membranes in the eyes, nose, throat and lungs.[4] It causes immediate closing of the eyes, difficulty ... and bodily injury results to any person from such gas or odor, the offending person shall be guilty of a Class 3 felony. If ... "A Randomized Controlled Trial Comparing Treatment Regimens for Acute Pain for Topical Oleoresin Capsaicin (Pepper Spray) ...
2) The biomarker levels must be elevated in various forms and/or severities of human TBI in the acute phase (3-24 h post-injury ... and lung cancer, and in melanoma.[3] ... fluid percussion injury [FPI], close head injury [CHI], ... dendritic injury, neuronal cell body injury, demyelination, synaptic injury and astroglia injury, and microglia responses. ... Neurotrauma : a comprehensive textbook on traumatic brain injury and spinal cord injury. Wang, Kevin K. W. New York: Oxford ...
"Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism ... though they are more sensitive to hyperoxic injury.[29] Knockout mice of any SOD enzyme are more sensitive to the lethal ... Diminished SOD3 activity has been linked to lung diseases such as Acute Respiratory Distress Syndrome (ARDS) or Chronic ... injury, herbicides and pesticides, ozone, plant metabolic activity, nutrient deficiencies, photoinhibition, temperature above ...
Head injury[edit]. A 2015 review found that moderate to severe traumatic brain injury is a risk factor for ALS, but whether ... As the diaphragm and intercostal muscles of the rib cage that support breathing weaken, measures of lung function such as vital ... mild traumatic brain injury increases rates was unclear.[63] A 2017 meta-analysis found an association between head injuries ... Watanabe Y, Watanabe T (October 2017). "Meta-analytic evaluation of the association between head injury and risk of amyotrophic ...
The process of acute inflammation is initiated by cells already present in all tissues, mainly resident macrophages, dendritic ... When host cells die, either by programmed cell death (also called apoptosis) or by cell injury due to a bacterial or viral ... lungs, stomach, and intestines.[7] They are named for their resemblance to neuronal dendrites, but dendritic cells are not ... The innate immune response to infectious and sterile injury is modulated by neural circuits that control cytokine production ...
August 1998). "Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi". Arch ... "National Heart, Lung, and Blood Institute. October 1, 2010. Retrieved January 15, 2014.. ... in a toxic mold-related personal injury lawsuit against the owners and managers of their apartment in Sacramento, California.[ ... People at higher risk for mold allergies are people with chronic lung illnesses, which will result in more severe reactions ...
THC is highly lipophilic and initially taken up by tissues that are highly perfused, such as the lung, heart, brain, and liver. ... Thompson, George R.; Rosenkrantz, Harris; Schaeppi, Ulrich H.; Braude, Monique C. (July 1973). "Comparison of acute oral ... Vaping-associated pulmonary injury. *War on Drugs. *Cannabinoid hyperemesis syndrome (CHS). *List of investigational analgesics ...
"Drugs for preventing lung cancer in healthy people". The Cochrane Database of Systematic Reviews. 10: CD002141. doi:10.1002/ ... so it exhibits remarkably low acute toxicity.[4] More than two to three grams may cause indigestion, particularly when taken on ... Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury". Nutrition and Metabolic ... A 2013 Cochrane review found no evidence that vitamin C supplementation reduces the risk of lung cancer in healthy people or ...
... and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic ... 16,0 16,1 16,2 16,3 16,4 Scott J. P., Peters-Golden M. (September 2013)։ «Antileukotriene agents for the treatment of lung ... 165,0 165,1 165,2 «Acute asthma in adults: a review»։ Chest 125 (3): 1081-102։ 2004։ PMID 15006973։ doi:10.1378/chest.125.3. ... 101,0 101,1 Shah R., Saltoun, C. A. (May-Jun 2012)։ «Chapter 14: Acute severe asthma (status asthmaticus)»։ Allergy and Asthma ...
Air bubbles can leave the blood through the lungs. A patient with a right-to-left shunt is vulnerable to embolism from smaller ... Acute Care of at-Risk Newborns (ACoRN). *Pediatric basic life support (PBLS) ... One reason veins are preferred over arteries for intravascular administration is because the flow will pass through the lungs ... it is safer to insert with a relatively low risk of uncontrollable bleeding and essentially no risks of damage to the lungs or ...
Acute Lung Injury Treatment Market is expected to grow healthy rate in near future; Acute lung injury is observed as a part of ... Acute Lung Injury Treatment Market report presents a detailed overview of the present scope of growth for companies operating; ... systemic inflammatory process wherein the lung manifests symptoms similar to other tissues such as destruction in capillary ... Global Acute Lung Injury Market: Snapshot. Acute lung injury, a common condition characterized by acute severe hypoxia without ...
Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence ... This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and ... Bacterial infections Hyperoxia LPS and bacterial pneumonia Transfusion-related acute lung injury Ventilator-induced lung injury ... Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are ...
... reperfusion injury or acute lung injury (ALI) [1].. ALI and its more severe form acute respiratory distress syndrome (ARDS) are ... M. Cepkova and M. A. Matthay, "Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome," Journal of ... One pathological hallmark of acute lung injury and acute respiratory distress syndrome is the uncontrolled transmigration of ... "Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury," American ...
Clinical acute lung injury (ALI) is a major cause of acute respiratory failure in critically ill patients. There is ... Cytokine-mediated inflammation in acute lung injury.. Goodman RB1, Pugin J, Lee JS, Matthay MA. ... and anti-inflammatory cytokines play a major role in the pathogenesis of inflammatory-induced lung injury from sepsis, ... A recent multi-center clinical trial found that a lung-protective ventilatory strategy reduces mortality by 22% in patients ...
Studies were searched in PUBMED by using the terms "extravascular lung water" (EVLW) and "acute lung injury" (ALI) or "acute ... Extravascular Lung Water and Acute Lung Injury. Ritesh Maharaj. Division of Intensive Care Medicine, Kings College Hospital, ... F. Michard, V. Zarka, S. Alaya, S. Sakka, and M. Klein, "Better characterization of acute lung injury/ARDS using lung water," ... Both experimental and clinical studies were searched in PUBMED using the term "extravascular lung water" and "acute lung injury ...
... acute respiratory distress syndrome (ARDS), is characterized by increased vascular and epithelial permeability, ... The pathophysiology of acute lung injury (ALI) and its most severe form, ... Microparticles and acute lung injury Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L364-81. doi: 10.1152/ajplung. ... The pathophysiology of acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), is ...
Transfusion related acute lung injury (TRALI) has been an upcoming cause of transfusion related mortality. It is characterized ... Acute Kidney Injury : Acute Liver Injury. 1419 Words , 6 Pages * Blood Transfusion And Transfusion Related Acute Lung Injury. ... Acute Treatment Of Acute Kidney Injury. 967 Words , 4 Pages Acute kidney injury (AKI, previously referred to as acute renal ... Acute Kidney Injury : Acute Liver Injury. 1419 Words , 6 Pages Prerenal Acute Kidney Injury Pathophysiology The human body has ...
... , Transfusion Associated Acute Lung Injury, TRALI. ... Transfusion-Related Acute Lung Injury. Transfusion-Related Acute Lung Injury Aka: Transfusion-Related Acute Lung Injury, ... Transfusion-related acute lung injury, TRALI, Transfusion related acute lung injury (disorder), Transfusion related acute lung ... Results from immune mediated Neutrophil activation, endothelial injury, and capillary leak. *Acute Lung Injury is a result of ...
Studies of HPA axis activation and the role of relative adrenal insufficiency on the outcome of patients with acute lung injury ... relative adrenal insufficiency in patients with acute lung injury/ARDS is unknown. It is also unclear whether such a response, ... The National Heart, Lung, and Blood Institutes ARDS Network currently is testing the use of methylprednisolone in late ARDS. ... Previous Document: Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K.... ...
NIOSH-Author; Toxic-effects; Laboratory-animals; Leather-finishing; Chemical-composition; Fluorocarbons; Lung-disease; ...
Find facts about lung diseases, such as lung cancer, COPD, asthma. ... Learn how to improve your lung health. Make efforts towards clean air and smokefree living. ... What is LUNG FORCE?. LUNG FORCE unites women and their loved ones across the country to stand together in the fight against ... American Lung Association , 1-800-LUNGUSA (1-800-586-4872)1-800-LUNGUSA , Submit A Question , Live Chat ...
... has shown that adult stem cells from bone marrow can help treat acute lung injury. Acute lung ... Acute lung injury? Stem cell therapy may help - Oct 30, 2009. *Bone marrow stem-cell therapy could treat acute lung injury: ... Acute lung injury (ALI) can be caused by any major inflammation or injury to the lungs and is a major cause of death in ... Tags: acute lung injury, adult stem cells, air sacs, blood vessels, bone marrow, cause of death, cd34, cell population, chicago ...
1.9M grant to study two proteins that play roles in acute lung injury, a condition which affects thousands of people each year. ... URMC receives $1.9M to study acute lung injury. Mar. 31, 2017 ... to identify viable therapies that will limit acute lung injury ... ALI occurs when capillary-alveolar barriers in the lung are disrupted, resulting in a variety of dangerous symptoms that can ... Fazals current study aims to understand how BiP and mortalin control the proinflammatory and leaky phenotype of the lung, and ...
Acute Lung Injury. Lung Injury. Lung Diseases. Respiratory Tract Diseases. Respiration Disorders. Infant, Premature, Diseases. ... Critical Illness Sleep Acute Lung Injury Acute Respiratory Distress Syndrome Drug: Dexmedetomidine Drug: Midazolam and Fentanyl ... Critically ill patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) who receive mechanical ... on sleep and inflammation in critically ill patients with Acute Lung Injury and Acute Respiratory Disorder Syndrome (ALI/ARDS ...
... renal disease and acute lung injury. In the current study, we report that ACE2 could mediate the severe acute lung injury ... virus-induced acute lung injury and suggest that might be a useful potential therapeutic target for future influenza A (H7N9) ... which is a severe form of acute lung injury (ALI) that further contributes to morbidity. To date, no effective drugs that ... Although most infections resulted in respiratory illness, some severe cases resulted in acute respiratory distress syndrome ( ...
Velvet antler may prevent acute lung injury. Thursday, August 23, 2018 by: Edsel Cook Tags: acute lung injury, deer, dietary ... www.naturalnews.com/2018-08-23-velvet-antler-may-prevent-acute-lung-injury.html",Velvet antler may prevent acute lung injury,/a ... Acute lung injury (ALI) is a clinical condition where lung tissue is deprived of oxygen by conditions not involving ... Velvet antler may prevent acute lung injury. Herbal remedy that was effective against SARS found to be beneficial for acute ...
... lung edema, extended lung destruction (lung injury scores and lung histology), neutrophil recruitment in the lung, and cytokine ... Keywords: acid aspiration, ARDS, glutamine, ventilator-induced lung injury. Acute respiratory distress syndrome (ARDS) is a ... After ventilator use for 4 h, high TV resulted in greater lung injury physiologic and biologic indices. Compared with vehicle ... on a two-hit model for VILI after acid aspiration-induced lung injury in rats. Rats were intratracheally challenged with ...
... associated acute lung injury (ALI) accounts for about 70% mortality of SAP patients. However, there are no precise biomarkers ... Gamma-enolase predicts lung damage in severe acute pancreatitis-induced acute lung injury. ... Severe acute pancreatitis (SAP) associated acute lung injury (ALI) accounts for about 70% mortality of SAP patients. However, ... Severe acute pancreatitis-induced acute lung injury Alpha-enolase Gamma-enolase Sprague-Dawley rats ...
Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion.. Shasby DM, Fox RB, Harada RN, Repine JE. ... Increased numbers of granulocytes are found in lungs acutely injured by hyperoxia, but their contribution to lung injury ... exposure to hyperoxia for 72 h resulted in fewer granulocytes in lung lavages and less edematous lung injury. In contrast, when ... increased numbers of granulocytes were found in lung lavages and the degree of edematous lung injury increased to levels not ...
... this months Anesthesiology highlights the potential of cell-based therapies for the treatment of acute lung injury and acute ... "Acute lung injury and acute respiratory distress syndrome continue to be major causes of death in seriously ill patients," said ... Lam, however, emphasized that more animal studies need to be performed before EPC transplantation for acute lung injury can be ... Lam further explained that several pharmacologic agents have been examined in the management of acute lung injury over the past ...
Caloric restriction failed to improve outcomes in ventilator-dependent patients with acute lung injury, results of an NIH- ... The findings came from the Early Versus Delayed Enteral Feeding to Treat People with Acute Lung Injury or Acute Respiratory ... The EDEN Study involved 1,000 adults with acute lung injury or acute respiratory distress requiring ventilator support. ... Source Reference: Rice TW, et al "Initial trophic vs full enteral feeding in patients with acute lung injury. The EDEN ...
Adult stem cells from bone marrow can help treat acute lung injury, a new mice study by researchers at the University of ... Acute lung injury (ALI) can be caused by any major inflammation or injury to the lungs and is a major cause of death in ... Adult stem cells from bone marrow can help treat acute lung injury, a new mice study by researchers at the University of ... The researchers hope to explore the possibility of using stem cell therapy in human acute lung injury. Their results are ...
Requirement and role of C5a in acute lung inflammatory injury in rats.. M S Mulligan, E Schmid, B Beck-Schimmer, G O Till, H P ... In C6-deficient rats, CVF infusion caused the same level of lung injury (measured by leak of 125I-albumin) as found in C6- ... In the IgG immune complex model of lung injury, anti-C5a administered intratracheally (but not intravenously) reduced in a dose ... Polyclonal antibody to rat C5a was used to define the requirements for C5a in neutrophil-dependent inflammatory lung injury ...
Transfusion-related acute lung injury (TRALI) is a serious blood transfusion complication characterized by the acute onset of ... It is often impossible to distinguish TRALI from acute respiratory distress syndrome (ARDS). The typical presentation of TRALI ...
Similarly, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are regularly encountered and potentially ... Bersten AD, Edibam C, Hunt T, Moran J. Incidence and mortality of acute lung injury and the acute respiratory distress syndrome ... Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory ... Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress ...
... 25.05.2005 ... Female lung transplant recipients are significantly more likely to suffer from a type of injury to the transplanted lung called ... When the lung is transplanted into the recipient and all the blood vessels are reattached, injury to the lung may become ... which is an acute severe lung injury that occurs within the first 72 hours after the transplant and has a high mortality. Once ...
... including acute lung injury and the acute respiratory distress syndrome, chronic obstructive lung disease, and cystic fibrosis ... Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Am J Respir Cell Mol Biol. 2009 May ... In the lung, such inflammatory damage is believed to contribute to the pathogenesis of diverse lung diseases, ... of the epithelial cells to the itinerant leukocytes and their cytotoxic products and the consequences of this for lung injury ...
Homeostatic and early-recruited CD101− eosinophils suppress endotoxin-induced acute lung injury Chen Zhu, Qing-Yu Weng, Ling- ... Increase in circulating ACE-positive endothelial microparticles during acute lung injury Yusuke Takei, Mitsuhiro Yamada, Koji ... Diagnosis and outcome of acute respiratory failure in immunocompromised patients after bronchoscopy Philippe R. Bauer, Sylvie ... Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure Bram Rochwerg, Laurent ...
Lung Injury. Acute Lung Injury. Lung Diseases. Respiratory Tract Diseases. Respiration Disorders. Infant, Premature, Diseases. ... Acute Respiratory Distress Syndrome (ARDS) and a lesser condition that occurs prior to ARDS, Acute Lung Injury (ALI), are ... Acute Lung Injury. Acute Respiratory Distress Syndrome. Albuterol. Aerosolized. Critical Care. Ventilator. ... enhance clearance of lung edema and decrease pulmonary inflammation in patients with acute lung injury. Because beta-2 agonists ...
... induced acute tracheobronchial epithelial injury and its relationship to granulocyte emigration were studied in monkeys. Male ... Ozone-induced acute tracheobronchial epithelial injury: relationship to granulocyte emigration in the lung.. ... Ozone (10028156) (O3) induced acute tracheobronchial epithelial injury and its relationship to granulocyte emigration were ... Irritant-gases; In-vivo-studies; Lung-irritants; Histology; Laboratory-animals; Inhalation-studies; Lung-cells; Immune-reaction ...
  • Respiratory Failure during Pregnancy Synonyms ARDS (acute respiratory distress syndrome) during pregnancy ALI (acute lung injury) during pregnancy Ventilatory failure during pregnancy Severe pneumonia during pregnancy Pulmonary embolus (PE) during pregnancy Amniotic fluid embolus Related Conditions Status asthmaticus during pregnancy Mechanical ventilation during pregnancy 1. (thecardiologyadvisor.com)
  • Prone positioning (PP) in non-COVID-19 acute respiratory distress syndrome (ARDS) has an established evidence base, particularly in intubated and mechanically ventilated (IMV) patients. (rcpjournals.org)
  • Patients admitted to the intensive care unit (ICU) with acute respiratory distress syndrome (ARDS) suffer from profound weight loss while hospitalized and have nutritional related residual effects up to a year post-discharge. (grantome.com)
  • The nutritional care provided to ARDS patients typically consists of enteral nutrition (EN) while mechanically ventilated followed by a general diet when weaned from the ventilator. (grantome.com)
  • Cerebral malaria (CM) and malaria-associated acute lung injury/acute respiratory distress syndrome (MA-ALI/ARDS) are among the most severe complications of Plasmodium infection. (reading.ac.uk)
  • For a minority of subjects, the disease worsens approximately 5-10 days after symptom onset, resulting in complications such as acute respiratory distress syndrome (ARDS) and other organ failure. (ingenewpharma.com)
  • Cannabidiol reduced swelling and enhanced lung features in a murine design of acute lung injury. (medprocannabis.com)
  • Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria. (reading.ac.uk)
  • Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. (vanderbilt.edu)
  • Serje J. Exogenous surfactant preserve lung function and reduces alveolar Evans blue dye in flux in a rat model of ventilation-induced lung injury. (medigraphic.com)
  • Prevention of intracellular adenosine triphosphate depletion after subletal oxidant injury to rat tipe II alveolar epithelial cells with exogenous glutation and N-acetylcisteine. (medigraphic.com)
  • Surfactant protein A (SP-A) levels was measured by ELISA method and also Alveolar macrophages population percentages were measured by using Stereology of lung tissue method before and after the training program. (ac.ir)
  • While acute lung injury (ALI) and pulmonary edema are feared COVID-19 complications, many patients present with elevated cardiac biomarkers and evidence of left ventricular (LV) dysfunction," said Dr. McCants. (yankeepr.com)
  • Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial. (vanderbilt.edu)
  • As a clinician, Dr. Shanley specializes in the treatment of children with hypoxemic respiratory failure from acute lung injury and severe sepsis triggered by infection. (luriechildrens.org)
  • Is it safe to prescribe benzodiazepines or opioids for dyspnoea in interstitial lung disease? (ersjournals.com)
  • I have been a critical care nurse for over 25 years starting in the neuro-trauma critical care unit at R Adams Cowley Shock Trauma in Baltimore, MD. My current focus is critical care research both clinically and scientifically with a concentration in mechanical ventilation and understanding the pathophysiology of acute lung injury, acute respiratory distress syndrome and ventilator induced/associated lung injury. (aprvnetwork.org)
  • The time-controlled adaptive ventilation protocol: mechanistic approach to reducing ventilator-induced lung injury. (aprvnetwork.org)
  • Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI). (aprvnetwork.org)
  • Myocardial infarction, ventilator-induced acute lung injury, neuronal apoptosis, cognitive impairment and other inflammatory models. (ingenewpharma.com)
  • Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal acute lung injury (ALI) by driving hypercytokinemia and aggressive inflammation through mechanisms that remain elusive. (vaccinereport.org)
  • The runaway response can feel like inflammation of your airways, a high fever, and way too much mucus in your lungs. (prdistribution.com)
  • In mouse models of lung injury, CBD reduced lipopolysaccharide-induced acute pulmonary inflammation . (prdistribution.com)
  • Note how hesperidin has been reported to regulate these cytokines in experiments where severe inflammation was induced to affect the heart, lungs and brain. (ingenewpharma.com)
  • Using LPS, a component of the cell wall of gram-negative bacteria as an inflammatory agent, they showed the application of CBD resulted in decreased pulmonary inflammation and improvements in lung function in mouse models of inflammatory lung disease[ref]Ribeiro A, Almeida VI, Costola-de-souza C, et al. (medicalmarijuana.co.uk)
  • Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. (medicalmarijuana.co.uk)
  • Background and Aims: Between March 2019 and February 2020, there was an outbreak of acute lung injury associated with vaping tetrahydrocannabinol (THC), contaminated with vitamin E acetate, in the United States. (drugsandalcohol.ie)
  • Coronaviruses cause the common cold and more severe diseases, such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). (vitamindwiki.com)
  • The same association was noted for its predecessors, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). (yankeepr.com)
  • The team pointed to data procured from the severe acute respiratory syndrome (SARS) epidemic of 2003, which most prominently affected persons in their 30s and 40s-despite these younger patients reporting lower disease severity and risk of mortality versus older people with pre-existing conditions. (practicalcardiology.com)
  • Serum surfactant protein-A levels in patients with acute cardiogenic pulmonary edema and adult respiratory distress syndrome. (medigraphic.com)
  • Effect of the dialysis membrane in the treatment of patients with acute renal failure. (vanderbilt.edu)
  • Dr. McVerry is a pulmonologist and critical care physician whose research interest is focused on translational investigation of the biological mechanisms underlying the development and consequences of sepsis and acute lung injury. (zmescience.com)
  • This belief, they wrote, aligns with evidence of angiotensin II antagonists benefitting sepsis-associated acute lung injury. (practicalcardiology.com)
  • To study the role of the protective effect of N-acetylcisteine and exogenous surfactant on the acute pulmonary injury (API) induced by oxygen. (medigraphic.com)
  • Mechanical ventilation (MV) can induce lung oxidative stress, which plays an important role in pulmonary injury. (unesp.br)
  • Complementary proteomic and genetic experiments identify a possible therapeutic strategy for acute myeloid leukemia. (sciencemag.org)
  • In the present review, we will describe the pathophysiological aspects of acute lung injury induced by combined burn and smoke inhalation and examine various therapeutic approaches. (symptoma.mt)
  • Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress Hidetoshi Tsuda, Noritaka Kawada, Jun-ya Kaimori, Harumi Kitamura, Toshiki Moriyama, Hiromi Rakugi, Shiro Takahara, Yoshitaka Isaka Biochemical and Biophysical. (nwlifescience.com)
  • 8 Bucillamine has also been shown to prevent oxidative and reperfusion injury in heart and liver tissues 8 and is highly cell permeable for efficient delivery into cells. (revivethera.com)
  • Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. (vanderbilt.edu)
  • Initial case reports of vaping-related lung injury date back to 2012, but the ongoing outbreak of EVALI began in the summer of 2019 and has been implicated in 2,807 cases and 68 deaths as of this writing. (stanford.edu)
  • Are isofurans and neuroprostanes increased after subarachnoid hemorrhage and traumatic brain injury? (vanderbilt.edu)
  • Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness. (vanderbilt.edu)
  • of Johns Hopkins School of Medicine, the National Institute on Aging and National Institutes of Health-called for the urgent expansion of renin-angiotensin system (RAS)-based intervention assessment as part of the need for clinical understanding as to how lung complications are driving novel coronavirus (COVID-19) mortality worldwide. (practicalcardiology.com)
  • Prone positioning improves oxygenation via better ventilation-to-perfusion matching and improved lung mechanics while reducing the potential for ventilator-associated lung injury. (elsevier.com)
  • Arnold, John H. / The prone position in acute lung injury . (elsevier.com)
  • Patients with activated immune systems may be prone to the acute lung injury sometimes seen after transfusions, but platelet-directed therapies may help. (sciencemag.org)
  • Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. (hku.hk)
  • Protection of acute lung injury due to oxygen exposure with N-acetylcisteine and exogenous surfactant in rats. (medigraphic.com)
  • Antioxidant-surfactant mitigate hyperoxic lung injury in premature rabbits. (medigraphic.com)
  • Lungs from the HSR group rats treated with or without biliverdin (BV) were excised 12 h after resuscitation and lung wet/dry ratio was measured. (figshare.com)
  • The age-associated decrease of ACE2 expression, which investigators have observed in the lungs of rats, is in line with "a constellation of major proinflammatory changes perpetrated by an age-associated increase in RAS signaling throughout the body," the team wrote. (practicalcardiology.com)
  • The common findings in thoracic high-resolution computed tomography in NSIP are bilateral reticular opacities, traction bronchiectasis, reduced volume of the lobes, and ground-glass opacity in the lower lungs. (e-trd.org)
  • These lesions can involve diffuse bilateral lungs or subpleural area. (e-trd.org)
  • 7 Studies in human cells and animal models have shown that NAC works to prevent acute lung injury caused by influenza virus infection through inhibition of these ROS-mediated mechanisms. (revivethera.com)
  • It is also reasonable to hypothesize that similar processes related to ROS are involved in acute lung injury during nCov-19 infection, possibly justifying the investigation of bucillamine as an intervention for COVID-19. (revivethera.com)
  • Recent findings support the hypothesis that a preclinical lung injury characterized by an enhanced inflammatory response is present in potential donors and may predispose recipients to an adverse clinical prognosis following lung transplantation. (nih.gov)
  • Lung wet/dry ratio after hemorrhagic shock and resuscitation (HSR). (figshare.com)
  • Although evidence supports immunomodulatory treatment for myocardial injury associated with severe influenza, there is not yet an evidence-based approach to treat the cytokine milieu associated with COVID-19 and the immunologic storm associated with systemic inflammatory response syndrome (SIRS). (yankeepr.com)
  • All smoke irritates the lungs and aggravates COPD, but vaporized or ingested cannabis could potentially provide many benefits because of its anti-inflammatory, immunosuppressant, and bronchodilating (airway opening) qualities. (medicalmarijuana.co.uk)
  • The patient presented 2 months after his injury with progressive stridor and dyspnea necessitating tracheostomy. (symptoma.mt)
  • See: carbon monoxide Symptoms Patients who have suffered smoke inhalation injury may complain of dyspnea , cough, and black sputum. (symptoma.mt)
  • Other findings such as conjunctivitis, stridor, dyspnea , disorientation, obtundation and coma are also indicative of inhalation injury. (symptoma.mt)
  • Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 3. (e-trd.org)
  • Lee, Kim, Kang, Jegal, Park, and on behalf of Korean Interstitial Lung Diseases Study Group: Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 3. (e-trd.org)
  • Diagnosis of inhalation injury should be suspected in patients with facial burns , singed nasal hair, cough, carbonaceous sputum, or evidence of upper airway edema, including hoarseness, stridor, or wheezing. (symptoma.mt)
  • Acute exacerbations are acute, clinically significant deteriorations of unidentifiable cause in patients with underlying IPF. (insightsinipf.com)
  • The ongoing U.S. outbreak of vaping-related acute lung injury, recently named EVALI (E-cigarette or vaping product use associated acute lung injury), has reignited concerns about the health effects of vaping. (stanford.edu)
  • EN is a medical intervention that has risks and cost yet no studies have demonstrated its efficacy in this population. (grantome.com)
  • Isofurans: novel products of lipid peroxidation that define the occurrence of oxidant injury in settings of elevated oxygen tension. (vanderbilt.edu)
  • There is an urgent need to monitor and manage myocardial injury during hospitalization for severely or critically ill COVID-19 patients," said Octapharma USA President Flemming Nielsen. (yankeepr.com)
  • Ischemia-Reperfusion Injury during Ascending Aortic Surgery: Comparative Effects of Deferoxamine and N-Acetylcysteine as Antioxidants Maged S. Abdallah MD, Osama M. Assad MD, Tarek Al Taweel MD, Ahmed Gaafar MD, Dalia A, Labib MD Journal of The. (nwlifescience.com)
  • A comparison of external fixation and locked intramedullary nailing in the treatment of femoral diaphysis fractures from gunshot injuries. (surgery.by)
  • Although smoked cannabis also has this effect, any kind of combustion creates other lung irritants that would be counterproductive for COPD treatment. (medicalmarijuana.co.uk)
  • Revive has a history in the clinical development with Bucillamine in the treatment of acute gout flares and cystinuria, and we will advance our efforts in reviving and exploring new uses of Bucillamine for unmet medical needs. (revivethera.com)
  • The two primary forms of COPD are chronic bronchitis , which produces a long-term cough with mucus, and emphysema , which leads to the progressive deterioration of the alveoli, the air sacs that allow for gaseous exchange in the lungs. (medicalmarijuana.co.uk)
  • Limiting ventilator-associated lung injury in a preterm porcine neonatal model. (aprvnetwork.org)
  • The effects of airway pressure release ventilation on respiratory mechanics in extrapulmonary lung injury. (aprvnetwork.org)
  • Preemptive mechanical ventilation can block progressive acute lung injury. (aprvnetwork.org)
  • Airway pressure release ventilation reduces conducting airway micro-strain in lung injury. (aprvnetwork.org)
  • Those with COPD have a heightened immune response in the lungs and compounds in cannabis can lead to immunosuppression. (medicalmarijuana.co.uk)
  • Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. (vanderbilt.edu)
  • Exposure to silica dust from cutting, grinding or polishing product can cause acute lung injury or cancer. (tilebuys.com)