Acute lung injury. Medical search

A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.

A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

Pathological processes involving any part of the LUNG.

Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.

Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.

Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.

Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).

Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.

Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.

An abnormal increase in the amount of oxygen in the tissues and organs.

Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.

The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.

Infection of the lung often accompanied by inflammation.

Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.

The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.

A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.

Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.

Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)

A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.

Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.

Artificial respiration (RESPIRATION, ARTIFICIAL) using an oxygenated fluid.

The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.

A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.

Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.

Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Tumors or cancer of the LUNG.

Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.

Mechanical devices used to produce or assist pulmonary ventilation.

The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)

The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.

Disease having a short and relatively severe course.

Injuries incurred during participation in competitive or non-competitive sports.

Measurement of oxygen and carbon dioxide in the blood.

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).

The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

The circulation of the BLOOD through the LUNGS.

An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)

The posture of an individual lying face down.

A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.

Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.

Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.

A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.

The transference of either one or both of the lungs from one human or animal to another.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)

An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.

An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.

Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Hospital units providing continuous surveillance and care to acutely ill patients.

The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.

An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.

Ventilatory support system using frequencies from 60-900 cycles/min or more. Three types of systems have been distinguished on the basis of rates, volumes, and the system used. They are high frequency positive-pressure ventilation (HFPPV); HIGH-FREQUENCY JET VENTILATION; (HFJV); and high-frequency oscillation (HFO).

Elements of limited time intervals, contributing to particular results or situations.

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).

A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.

A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.

Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.

A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

General or unspecified injuries involving the leg.

Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

That part of the RESPIRATORY TRACT or the air within the respiratory tract that does not exchange OXYGEN and CARBON DIOXIDE with pulmonary capillary blood.

Techniques for supplying artificial respiration to a single lung.

An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.

The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.

A disease or state in which death is possible or imminent.

A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.

Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.

The number of times an organism breathes with the lungs (RESPIRATION) per unit time, usually per minute.

The force per unit area that the air exerts on any surface in contact with it. Primarily used for articles pertaining to air pressure within a closed environment.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Health care provided to a critically ill patient during a medical emergency or crisis.

Drugs used for their effects on the respiratory system.

A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.

A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.

Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).

Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

A pathological condition manifested by failure to perfuse or oxygenate vital organs.

The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.

A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.

The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.

Burns of the respiratory tract caused by heat or inhaled chemicals.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)

Substances that reduce or suppress INFLAMMATION.

A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.

Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.

Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

General or unspecified injuries to the chest area.

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.

Inflammation of the lung parenchyma that is caused by bacterial infections.

General or unspecified injuries involving organs in the abdominal cavity.

The dialdehyde of malonic acid.

Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.

The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.

Relatively complete absence of oxygen in one or more tissues.

General or unspecified injuries involving the arm.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.

Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)

Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.

General or unspecified injuries to the hand.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.

A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.

Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.

Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.

The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.

A greenish-yellow, diatomic gas that is a member of the halogen family of elements. It has the atomic symbol Cl, atomic number 17, and atomic weight 70.906. It is a powerful irritant that can cause fatal pulmonary edema. Chlorine is used in manufacturing, as a reagent in synthetic chemistry, for water purification, and in the production of chlorinated lime, which is used in fabric bleaching.

Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.

Hospital units providing continuous surveillance and care to acutely ill infants and children. Neonates are excluded since INTENSIVE CARE UNITS, NEONATAL is available.

Epithelial cells that line the PULMONARY ALVEOLI.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.

Injuries involving the vertebral column.

A fibroblast growth factor that is a specific mitogen for EPITHELIAL CELLS. It binds a complex of HEPARAN SULFATE and FIBROBLAST GROWTH FACTOR RECEPTOR 2B.

A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.

X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.

Injuries to the knee or the knee joint.

A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.

A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.

A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.

The measurement of an organ in volume, mass, or heaviness.

Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.

A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.

General or unspecified injuries to the heart.

Liquid components of living organisms.

Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.

A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.

Classification system for assessing impact injury severity developed and published by the American Association for Automotive Medicine. It is the system of choice for coding single injuries and is the foundation for methods assessing multiple injuries or for assessing cumulative effects of more than one injury. These include Maximum AIS (MAIS), Injury Severity Score (ISS), and Probability of Death Score (PODS).

An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.

The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.

The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.

The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.

A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.

The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.

A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.

A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.

White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).

The relationship between the dose of an administered drug and the response of the organism to the drug.

Bleeding or escape of blood from a vessel.

The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.

A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.

General or unspecified injuries to the soft tissue or bony portions of the face.

The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.

A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.

The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

A type of shock that occurs as a result of a surgical procedure.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.

The natural enzymatic dissolution of FIBRIN.

Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Transfusion related acute lung injury (TRALI) caused by red blood cell transfusion involving residual plasma anti-HLA antibodies: a report on two cases and general considerations. (1/1061)

TRALI is considered a serious hazard among immune complications of blood transfusion and its occurrence is admitted to be globally underestimated. Each type of blood product is likely to cause TRALI. We report here on two consecutive observations of TRALI caused by red blood cell concentrates, in which anti-HLA class I and class II antibodies resulting from post-gravitational allo-immunization were evidenced in donors. HLA class I and II antigenic community between recipients and donors' husbands were found and strong reacting IgG antibodies directed at several of those common antigens were detected in the donors' serum. Both donors had more than 3 pregnancies, raising the issue of blood donor selection or of plasma reduction for cellular products. (+info)

Mechanisms of pulmonary dysfunction after on-pump and off-pump cardiac surgery: a prospective cohort study. (2/1061)

BACKGROUND: Pulmonary dysfunction following cardiac surgery is believed to be caused, at least in part, by a lung vascular injury and/or atelectasis following cardiopulmonary bypass (CPB) perfusion and collapse of non-ventilated lungs. METHODS: To test this hypothesis, we studied the postoperative pulmonary leak index (PLI) for 67Ga-transferrin and (transpulmonary) extravascular lung water (EVLW) in consecutive patients undergoing on-pump (n = 31) and off-pump (n = 8) cardiac surgery. We also studied transfusion history, radiographs, ventilatory and gas exchange variables. RESULTS: The postoperative PLI and EVLW were elevated above normal in 42 and 29% after on-pump surgery and 63 and 37% after off-pump surgery, respectively (ns). Transfusion of red blood cell (RBC) concentrates, PLI, EVLW, occurrence of atelectasis, ventilatory variables and duration of mechanical ventilation did not differ between groups, whereas patients with atelectasis had higher venous admixture and airway pressures than patients without atelectasis (P = 0.037 and 0.049). The PLI related to number of RBC concentrates infused (P = 0.025). CONCLUSION: The lung vascular injury in about half of patients after cardiac surgery is not caused by CPB perfusion but by trauma necessitating RBC transfusion, so that off-pump surgery may not afford a benefit in this respect. However, atelectasis rather than lung vascular injury is a major determinant of postoperative pulmonary dysfunction, irrespective of CPB perfusion. (+info)

Toward early identification of acute lung injury in the emergency department. (3/1061)

BACKGROUND: There are no studies evaluating the epidemiology of pediatric acute lung injury (ALI) in the emergency department (ED), where early identification and interventions are most likely to be helpful. The purpose of this study was to describe the epidemiology of the ALI precursor acute hypoxemic respiratory failure (AHRF) in the ED. METHODS: We analyzed 11,664 pediatric patient records from 16 EDs. Records were selected if oxygen saturation (SpO(2)) was recorded during the visit. Virtual partial pressure of oxygen (pO(2)) was calculated from SpO(2), thus allowing calculation of ratios of pO(2) to fraction of inspired oxygen (FiO(2)) (PFRs). Patients with a PFR < 300 were classified as having AHRF. Univariate analyses and logistic regression were used to test the association of clinical factors with the presence of AHRF and intubation. RESULTS: AHRF criteria (ie, PFR < 300) were met in 121 (2.9%) of the 4,184 patients with an oxygenation measurement. The following variables were independently associated with ALI: higher Pediatric Risk of Admission II score (adjusted odds ratio [95% confidence interval (CI)] = 1.12 [1.08-1.16]; p < .001), higher heart rate (1.02 [1.01-1.03]; p = .009), a positive chest radiograph (2.35 [1.02-5.43]; p = .045), and lower temperature (0.49 [0.36-0.68]; p < .001).The final model had an R(2) = .20. CONCLUSION: We found nonintubated AHRF to be prevalent in the ED. The low R(2) for the regression model for AHRF underscores the lack of criteria for early identification of patients with respiratory compromise. Our findings represent an important first step toward establishing the true incidence of ALI in the pediatric ED. (+info)

Keratinocyte growth factor protects against Clara cell injury induced by naphthalene. (4/1061)

(+info)

NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells. (5/1061)

(+info)

Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury. (6/1061)

(+info)

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. (7/1061)

(+info)

Predictors of mortality in acute lung injury during the era of lung protective ventilation. (8/1061)

(+info)

Transfusion-associated acute lung injury (TRALI) is a syndrome that is similar to Acute respiratory distress syndrome (ARDS), ... "Transfusion-related acute lung injury; clinical perspectives". Korean Journal of Anaesthesiology. 68 (2): 101-105. doi:10.4097/ ... Acute hemolytic reactions are defined according to Serious Hazards of Transfusion (SHOT) as "fever and other symptoms/signs of ... Kidney injury may occur because of the effects of the hemolytic reaction (pigment nephropathy).[29] The severity of the ...

https://en.wikipedia.org/wiki/Blood_transfusion

Acute lung injury may also cause pulmonary edema through injury to the vasculature and parenchyma of the lung. Acute lung ... Transfusion associated Acute Lung Injury (TRALI) is a specific type of blood-product transfusion injury that occurs when the ... Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... "Transfusion-related acute lung injury (TRALI)". Professional Education. 2016-06-17. Retrieved 2016-12-03.. ...

https://en.wikipedia.org/wiki/Pulmonary_edema

... the definition of acute lung injury), or. *arterial partial-pressure of carbon dioxide (PaCO2) , 65 torr (20 mmHg) over ... Lungs: acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory ... Acute renal failure. Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction ... Increased permeability of the lung vessels causes leaking of fluids into alveoli, which results in pulmonary edema and acute ...

https://en.wikipedia.org/wiki/Sepsis

Kawabata K, Hagio T, Matsuoka S (September 2002). "The role of neutrophil elastase in acute lung injury". European Journal of ... of neutrophil elastase can lead to disruption of pulmonary barrier showing symptoms corresponding with acute lung injury.[42] ... Neutrophils are recruited to the site of injury within minutes following trauma and are the hallmark of acute inflammation;[11] ... During the beginning (acute) phase of inflammation, particularly as a result of bacterial infection, environmental exposure,[6] ...

https://en.wikipedia.org/wiki/Neutrophil_granulocyte

A 2006 Awake! highlighted dangers from transfusion-related acute lung injury (TRALI).[94] ... Heart-Lung Machine, a method in which blood is diverted to an artificial heart-lung machine and directed back into the patient. ...

https://en.wikipedia.org/wiki/Jehovah's_Witnesses_and_blood

... transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a ... "Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside". Blood Reviews. 29 (1): 51- ... "Antibody-mediated transfusion-related acute lung injury; from discovery to prevention". British Journal of Haematology. 170 (5 ... infections through better skin cleansing procedures and the incidence of life-threatening transfusion-related acute lung injury ...

https://en.wikipedia.org/wiki/Serious_Hazards_of_Transfusion

These gaseous products can cause acute lung injury. Chronic exposure, for example, from the air at swimming pools where ...

https://en.wikipedia.org/wiki/Sodium_hypochlorite

In the case of non-allergic acute lung injury, standard or recommended approaches to treatment have not been defined.[10] ... "Chemical Pneumonitis and Acute Lung Injury Caused by Inhalation of Nickel Fumes". Internal Medicine. 50 (18): 2035-8. doi: ... Patients may present with wheezing or crackles in the lungs. They typically have an increased white blood cell count, and urine ... an event which occurs by inhaling metal oxide fumes that injure the lung cells. This is not an allergic reaction, though ...

https://en.wikipedia.org/wiki/Metal_fume_fever

"Female Plasma May Not Increase Risk for Transfusion-Related Acute Lung Injury". Medscape. October 23, 2007. Retrieved 2011-07- ... because of concerns about transfusion related acute lung injury (TRALI) and female donors who may have higher leukocyte ...

https://en.wikipedia.org/wiki/Blood_plasma

A 2006 Awake! highlighted dangers from transfusion-related acute lung injury (TRALI). Opposition to the Watch Tower doctrines ... Heart-Lung Machine, a method in which blood is diverted to an artificial heart-lung machine and directed back into the patient ...

https://en.wikipedia.org/wiki/Jehovah's_Witnesses_and_blood_transfusions

... especially in the context of ARDS and acute lung injury. This is commonly referred to as lung protective ventilation. There are ... Krishnan JA, Brower RG (2000). "High-frequency ventilation for acute lung injury and ARDS". Chest. 118 (3): 795-807. doi: ... Jet ventilation has been shown to reduce ventilator induced lung injury by as much as 20%. Usage of high-frequency jet ... High frequency ventilation is thought to reduce ventilator-associated lung injury (VALI), ...

https://en.wikipedia.org/wiki/High-frequency_ventilation

Kawabata K, Hagio T, Matsuoka S (September 2002). "The role of neutrophil elastase in acute lung injury". European Journal of ... Moraes TJ, Chow CW, Downey GP (April 2003). "Proteases and lung injury". Critical Care Medicine. 31 (4 Suppl): S189-94. doi: ... acute respiratory distress syndrome, and cystic fibrosis. A recent study shows that patients with CTSG gene polymorphisms have ... ischemic reperfusion injury, and bone metastasis. It is also implicated in a variety of infectious inflammatory diseases, ...

https://en.wikipedia.org/wiki/Cathepsin_G

Otrock, Z. K.; Liu, C.; Grossman, B. J. (2017). "Transfusion-related acute lung injury risk mitigation: An update". Vox ... transfusion-related acute lung injury (TRALI), transfusion associated graft versus host disease and febrile non-hemolytic ... management and prevention of transfusion-related acute lung injury: A comprehensive update". Expert Review of Hematology. 12 (9 ... "Home , National Heart, Lung, and Blood Institute (NHLBI)". www.nhlbi.nih.gov. Retrieved 2018-07-25. Breymann, Christian ( ...

https://en.wikipedia.org/wiki/Anemia_in_pregnancy

Ventilator-associated lung injury, an acute lung injury that develops during mechanical ventilation ... Ventilator-associated pneumonia, a type of lung infection that occurs in people who are on mechanical ventilation ... is a machine designed to provide mechanical ventilation by moving breathable air into and out of the lungs. ...

https://en.wikipedia.org/wiki/Ventilator_

Brochard LJ (November 2009). "Tidal volume during acute lung injury: let the patient choose?". Intensive Care Medicine. 35 (11 ... As a result, the pressure in the airway drops, causing an inflow of air into the lungs. With NAVA, the electrical activity of ... Del Sorbo L, Slutsky AS (February 2010). "Ventilatory support for acute respiratory failure: new and ongoing pathophysiological ... March 2010). "Neurally adjusted ventilatory assist increases respiratory variability and complexity in acute respiratory ...

https://en.wikipedia.org/wiki/Neurally_adjusted_ventilatory_assist

TACO and transfusion related acute lung injury (TRALI) are often difficult to distinguish in the acute situation. TACO is ... Popovsky, M. A. (September 2006). "Transfusion-related acute lung injury and transfusion-associated circulatory overload". ISBT ... "Distinguishing between transfusion related acute lung injury and transfusion associated circulatory overload". Current Opinion ... Low albumin Cardiovascular disease Kidney disease Lung disease Severe anemia Age (less than 3 years old and over 60 years old) ...

https://en.wikipedia.org/wiki/Transfusion_associated_circulatory_overload

Ventilator-associated lung injury (VALI) refers to acute lung injury that occurs during mechanical ventilation. It is ... One of the primary complications that presents in patients mechanically ventilated is acute lung injury (ALI)/acute respiratory ... Common specific medical indications for use include: Acute lung injury, including acute respiratory distress syndrome (ARDS) ... "Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory ...

https://en.wikipedia.org/wiki/Mechanical_ventilation

"Long pentraxin 3 in pulmonary infection and acute lung injury". American Journal of Physiology. Lung Cellular and Molecular ... PTX3 behaves as an acute phase response protein, as the blood levels of PTX3, low in normal conditions (about 25 ng/mL in the ... Lee GW, Goodman AR, Lee TH, Vilcek J (October 1994). "Relationship of TSG-14 protein to the pentraxin family of major acute ... is a novel member of the pentaxin family of acute phase proteins". Journal of Immunology. 150 (5): 1804-12. PMID 7679696. Alles ...

https://en.wikipedia.org/wiki/PTX3

"Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury". PLOS Pathogens. 13 (6): ... Absence of the enzyme renders mice more likely to develop severe lung injury and die if they are challenged with intratracheal ... 2018). "LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma". J Exp Med. 215 (9): ... Other studies found that AOAH reduced translocation of stimulatory LPS from the gastrointestinal microbiota to the lung, where ...

https://en.wikipedia.org/wiki/AOAH

"Management of acute lung injury: sharing data between adults and children". Respiratory Care. 56 (9): 1258-68, discussion 1268- ... They practice in acute care facilities, long-term acute care facilities, skilled nursing facilities, assisted-living centers, ... Scientific research also takes place to look for causes and possible treatment in diseases such as asthma and lung cancer. The ... Respiratory therapists are also primary clinicians in conducting tests to measure lung function and teaching people to manage ...

https://en.wikipedia.org/wiki/Respiratory_therapist

"Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury". The Journal of Clinical ... This effect is seen not only with neutrophils in the blood, but also in various tissues such as the gut, lung, liver, and blood ... specifically in the lung capillaries and liver sinusoids). Intra-vascular NET formation is tightly controlled and is regulated ... "Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke". Stroke. 49 (3): 754- ...

https://en.wikipedia.org/wiki/Neutrophil_extracellular_traps

His initial research focused on animal models of acute lung injury. Montaner initially planned on returning to Argentina after ... Montaner, J.G.; Russel, J.; Lawson, L.; Ruedy, J. (1989). "Acute Respiratory Failure Secondary to Pneumocystis Carinii ...

https://en.wikipedia.org/wiki/Julio_Montaner

2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. ...

https://en.wikipedia.org/wiki/PDE2A

Of people who have survived drowning, almost one-third will experience complications such as acute lung injury (ALI) or acute ... Jin, Faguang; Li, Congcong (5 April 2017). "Seawater-drowning-induced acute lung injury: From molecular mechanisms to potential ... Lung density may be higher than normal, but normal weights are possible after cardiac arrest or vasovagal reflex. The lungs may ... Inhaled fluid can act as an irritant inside the lungs. Even small quantities can cause the extrusion of liquid into the lungs ( ...

https://en.wikipedia.org/wiki/Drowning

2006). "The role of metallothionein in the pathogenesis of acute lung injury". Am. J. Respir. Cell Mol. Biol. 34 (1): 73-82. ...

https://en.wikipedia.org/wiki/RNF13

Amirshahrokhi K, Bohlooli S (October 2013). "Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in ... "Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats". Archives of ... Schoenig G (1968). Acute oral toxicity of sample No. 751, dimethyl sulfone 1 BT No. A6409. Northbrook, Illinois: Industrial BIO ... The study also evaluated an acute 12g dose and found significant improvements in all symptoms except itching eyes and sneezing ...

https://en.wikipedia.org/wiki/Methylsulfonylmethane

... airway pressure release ventilation is indicated in patients with acute lung injury, acute respiratory distress syndrome and ... 1991). "Airway pressure release ventilation during acute lung injury: a prospective multicenter trial". Critical Care Medicine ... 2003). "Spontaneous breathing improves lung aeration in oleic acid-induced lung injury". Anesthesiology. 99 (2): 376-84. doi: ... "Long-term effects of two different ventilatory modes on oxygenation in acute lung injury. Comparison of airway pressure release ...

https://en.wikipedia.org/wiki/Airway_pressure_release_ventilation

Non-infectious diseases that may result in symptoms similar to those of EVD include acute promyelocytic leukaemia, haemolytic ... but not very much in their lungs.[77] It is believed that this is the reason researchers have observed pig to primate ... The breakdown of endothelial cells leading to blood vessel injury can be attributed to EBOV glycoproteins. This damage occurs ... pigs with EVD get very high ebolavirus concentrations in their lungs, and not their bloodstream.[76] Therefore, pigs with EVD ...

https://en.m.wikipedia.org/wiki/Ebola_virus_disease

Acute graft-versus-host disease typically occurs in the first 3 months after transplantation and may involve the skin, ... Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of bilirubin, hepatomegaly and fluid ... The injury of the mucosal lining of the mouth and throat is a common regimen-related toxicity following ablative HSCT regimens ... However, it is less effective in rapidly growing acute leukemias.[38] If cancer relapses after HSCT, another transplant can be ...

https://en.wikipedia.org/wiki/Bone_Marrow_Transplant

Physical medicine and rehabilitation (or physiatry) is concerned with functional improvement after injury, illness, or ... These include treatment of acute and chronic illnesses, preventive care and health education for all ages and both sexes. ... lungs, digestive tract, urinary tract, etc.). ... injuries, past infectious diseases or vaccinations, history of ... Sports medicine deals with the treatment and prevention and rehabilitation of sports/exercise injuries such as muscle spasms, ...

https://en.wikipedia.org/wiki/Medical

Global Initiative for Chronic Obstructive Lung Disease. halaman 1-7.. *^ Craig JA (2012). Ferri's netter patient advisor (ed. ... GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (October 2016). "Global, regional, and national incidence, ... "Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive ... Global Initiative for Chronic Obstructive Lung Disease. halaman 9-17.. *^ Reilly JJ, Silverman EK, Shapiro SD (2011). "Chronic ...

https://ms.m.wikipedia.org/wiki/Penyakit_paru-paru_obstruktif_kronik

Spinal manipulation may be cost-effective for sub-acute or chronic low back pain but the results for acute low back pain were ... Ndetan HT, Rupert RL, Bae S, Singh KP (February 2009). "Prevalence of musculoskeletal injuries sustained by students while ... the lungs, or the stomach) that subluxation significantly contributes to, the mean response was 62%.[37] A 2008 survey of 6,000 ... There is moderate quality evidence to support the use of SM for the treatment of acute lumbar radiculopathy[101] and acute ...

https://en.wikipedia.org/wiki/Chiropractors

Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging. ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... brain tumors are second only to acute lymphoblastic leukemia as the most common form of cancer.[8] In Australia, the average ... with about half of metastases coming from lung cancer.[2] Primary brain tumors occur in around 250,000 people a year globally, ...

https://en.m.wikipedia.org/wiki/Brain_tumors

2004). 1992-2001 Census of fatal occupational injuries (CFOI) Revised data. Washington, DC: U.S. Department of Labor, Bureau of ... Theorell, T.; Hasselhorn, H.; Vingård, E.; Andersson, B. (2000). "Interleukin 6 and cortisol in acute musculoskeletal disorders ... Byssinosis ("brown lung"). *Chalicosis. *Chimney sweeps' carcinoma. *Chronic solvent-induced encephalopathy (CSE) ... Kidd, P., Scharf, T., & Veazie, M. (1996). Linking stress and injury in the farming environment: A secondary analysis. Health ...

https://en.wikipedia.org/wiki/Occupational_health_psychology

However, inhaled A1AT may not reach the elastin fibers in the lung where elastase injury occurs. Further study is currently ... Kushner, Mackiewicz A (1993). The acute phase response: an overview. Acute-phase glycoproteins: molecular biology, biochemistry ... In the acute phase reaction, a further elevation is required to "limit" the damage caused by activated neutrophil granulocytes ... This involves inhaling purified human A1AT into the lungs and trapping the A1AT into the lower respiratory tract. ...

https://en.wikipedia.org/wiki/Alpha-1_antitrypsin

Leach, Richard E. (2009). Acute and Critical Care Medicine at a Glance (ika-2nd (na) edisyon). Wiley-Blackwell. ISBN 1-4051- ... Diffuse parenchymal lung disease : ... 47 tables (ika-[Online-Ausg.] (na) edisyon). Basel: Karger. 2007. pa. 4. ISBN 978-3-8055 ... "WHO Disease and injury country estimates". World Health Organization (WHO). 2004. Nakuha noong 11 November 2009.. ... Vijayan, VK (2009 May). "Parasitic lung infections". Current opinion in pulmonary medicine. 15 (3): 274-82. PMID 19276810.. ...

https://tl.wikipedia.org/wiki/Pulmonya

Acute toxicity occurs over a period of hours or a few days, and is less of a problem than chronic toxicity. ... while the lung and kidneys may also be capable of storage.[20] ... on ethanol-induced mitochondrial injury in rats". Biochemical ... "The acute and chronic toxic effects of vitamin A". The American Journal of Clinical Nutrition. 83 (2): 191-201. PMID 16469975 ...

https://en.m.wikipedia.org/wiki/Hypervitaminosis_A

... the two signature injuries are posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI). These two signature ... Music therapy may provide a means of improving mental health among people with schizophrenia, but its effects in acute ... Singing training has been found to improve lung, speech clarity, and coordination of speech muscles, thus, accelerating ... Neurological impairments following a brain injury can be in the form of apraxia - loss to perform purposeful movements, ...

https://en.m.wikipedia.org/wiki/Neurologic_music_therapy

Many different knee injuries can happen. Three percent of knee injuries are acute traumatic patellar dislocations.[25] Because ... "Injury. 41 (4): 329-334. doi:10.1016/j.injury.2009.08.007.. *^ Ringleb, Stacie I.; Dhakal, Ajaya; Anderson, Claude D.; Bawab, ... as injury to these structures may occur during the injury or during the reduction process.[3] Subsequent imaging studies are ... "Acromioclavicular injury , Radiology Reference Article , Radiopaedia.org". radiopaedia.org. Retrieved 2018-02-21.. ...

https://en.wikipedia.org/wiki/Joint_dislocation

Diet Drug Orlistat Linked to Kidney, Pancreas Injuries. Medscape. Medscape News. [2011-04-26]. （原始内容存档于2012-05-10）.. ... National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight ... The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk stratification of ... National Heart, Lung, and Blood Institute (NHLBI). Clinical Guidelines on the Identification, Evaluation, and Treatment of ...

https://zh.wikipedia.org/wiki/肥胖

If acute radiation exposure occurs in the first ten days following conception, when few cells have formed, it is likely that ... A consolidated lawsuit brought by two thousand Hanford downwinders for personal injury against the contractors that ran Hanford ... lung, colon, and thyroid tissues as the most radiosensitive among women. For example, the FGR 13 has estimated that the ratio ... Some downwinders may have suffered acute exposure due to their involvement in uranium mining and nuclear experimentation.[4] ...

https://en.wikipedia.org/wiki/Downwinders

Acute renal failure. Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction ... Lung Protective Ventilator Strategy utilising 5-8 mls/kg tidal volumes for mechanically ventilated patients to avoid volutrauma ...

https://en.wikipedia.org/wiki/Surviving_Sepsis_Campaign

Jun Chen, Zao C. Xu, Xiao-Ming Xu, Animal Models of Acute Neurological Injuries, Humana Press; 1 edition, ISBN 978-1-60327-184- ... The term also includes oxygen deprivation due to obstructions in the lungs. Choking, strangulation, the crushing of the ... Brain injury may still occur in a TIA lasting only a few minutes. Having a TIA is a risk factor for eventually having a stroke. ... Focal cerebral ischemia - A stroke occurring in a localized area that can either be acute or transient. This may be due to a ...

https://en.m.wikipedia.org/wiki/Brain_hypoxia

Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 2009-11-11. Retrieved ... Gross pathology of a lung showing centrilobular emphysema characteristic of smoking. This close-up of the fixed, cut lung ... For those with very severe disease, surgery is sometimes helpful and may include lung transplantation or lung volume-reduction ...

https://en.wikipedia.org/wiki/COPD

Transfusion-related acute lung injury. *Illness and injuries during spaceflight. Injury severity scoreEdit. The injury severity ... Other injuries from external physical causes, such as radiation poisoning, burn, or frostbite *Radiation-induced lung injury ... Injury from internal causes such as reperfusion injury. By locationEdit. *Wound, an injury in which skin is torn, cut or ... Traumatic injury, a body wound or shock produced by sudden physical collision or movement[9]*Avulsion injury ...

https://en.m.wikipedia.org/wiki/Injury

Acute lung injury and alveolar epithelial function. Masui. 57:51-9. Tang PS, Mura M, Seth R, Liu M. (2008) Acute lung injury ... 2007) Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future ... 2010) Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine ... 2008) Animal models of acute lung injury. Am J Physiol. 295:L379-99. Li X, Li S, Zhang M, Li X, Zhang X, Zhang W, Li C. (2010) ...

https://en.wikipedia.org/wiki/Acute_inhalation_injury

Brain injury (temporary or permanent). *Decreased muscle tone. This can be caused by drugs or alcohol, or it can be caused by ... The Epstein-Barr virus, for example, is known to be able to dramatically increase the size of lymphoid tissue during acute ... "Lung. 192 (1): 175-184. doi:10.1007/s00408-013-9511-3. PMC 4216726. PMID 24077936.. ... The permanent premature muscular tonal loss in the upper airway may be precipitated by traumatic brain injury, neuromuscular ...

https://en.m.wikipedia.org/wiki/Obstructive_sleep_apnea

Acute response[edit]. For individuals not previously exposed to OC effects, the general feelings after being sprayed can be ... It inflames the mucous membranes in the eyes, nose, throat and lungs.[4] It causes immediate closing of the eyes, difficulty ... and bodily injury results to any person from such gas or odor, the offending person shall be guilty of a Class 3 felony. If ... "A Randomized Controlled Trial Comparing Treatment Regimens for Acute Pain for Topical Oleoresin Capsaicin (Pepper Spray) ...

https://en.wikipedia.org/wiki/Pepper_spray

2) The biomarker levels must be elevated in various forms and/or severities of human TBI in the acute phase (3-24 h post-injury ... and lung cancer, and in melanoma.[3] ... fluid percussion injury [FPI], close head injury [CHI], ... dendritic injury, neuronal cell body injury, demyelination, synaptic injury and astroglia injury, and microglia responses. ... Neurotrauma : a comprehensive textbook on traumatic brain injury and spinal cord injury. Wang, Kevin K. W. New York: Oxford ...

https://en.m.wikipedia.org/wiki/Biomarkers

"Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism ... though they are more sensitive to hyperoxic injury.[29] Knockout mice of any SOD enzyme are more sensitive to the lethal ... Diminished SOD3 activity has been linked to lung diseases such as Acute Respiratory Distress Syndrome (ARDS) or Chronic ... injury, herbicides and pesticides, ozone, plant metabolic activity, nutrient deficiencies, photoinhibition, temperature above ...

https://en.wikipedia.org/wiki/Orgotein

Head injury[edit]. A 2015 review found that moderate to severe traumatic brain injury is a risk factor for ALS, but whether ... As the diaphragm and intercostal muscles of the rib cage that support breathing weaken, measures of lung function such as vital ... mild traumatic brain injury increases rates was unclear.[63] A 2017 meta-analysis found an association between head injuries ... Watanabe Y, Watanabe T (October 2017). "Meta-analytic evaluation of the association between head injury and risk of amyotrophic ...

https://en.wikipedia.org/wiki/Lou_Gehrig's_disease

The process of acute inflammation is initiated by cells already present in all tissues, mainly resident macrophages, dendritic ... When host cells die, either by programmed cell death (also called apoptosis) or by cell injury due to a bacterial or viral ... lungs, stomach, and intestines.[7] They are named for their resemblance to neuronal dendrites, but dendritic cells are not ... The innate immune response to infectious and sterile injury is modulated by neural circuits that control cytokine production ...

https://en.wikipedia.org/wiki/Innate_immune_system

August 1998). "Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi". Arch ... "National Heart, Lung, and Blood Institute. October 1, 2010. Retrieved January 15, 2014.. ... in a toxic mold-related personal injury lawsuit against the owners and managers of their apartment in Sacramento, California.[ ... People at higher risk for mold allergies are people with chronic lung illnesses, which will result in more severe reactions ...

https://en.m.wikipedia.org/wiki/Toxic_mold

THC is highly lipophilic and initially taken up by tissues that are highly perfused, such as the lung, heart, brain, and liver. ... Thompson, George R.; Rosenkrantz, Harris; Schaeppi, Ulrich H.; Braude, Monique C. (July 1973). "Comparison of acute oral ... Vaping-associated pulmonary injury. *War on Drugs. *Cannabinoid hyperemesis syndrome (CHS). *List of investigational analgesics ...

https://en.m.wikipedia.org/wiki/THC

"Drugs for preventing lung cancer in healthy people". The Cochrane Database of Systematic Reviews. 10: CD002141. doi:10.1002/ ... so it exhibits remarkably low acute toxicity.[4] More than two to three grams may cause indigestion, particularly when taken on ... Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury". Nutrition and Metabolic ... A 2013 Cochrane review found no evidence that vitamin C supplementation reduces the risk of lung cancer in healthy people or ...

https://en.wikipedia.org/wiki/L-ascorbic_acid

... and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic ... 16,0 16,1 16,2 16,3 16,4 Scott J. P., Peters-Golden M. (September 2013)։ «Antileukotriene agents for the treatment of lung ... 165,0 165,1 165,2 «Acute asthma in adults: a review»։ Chest 125 (3): 1081-102։ 2004։ PMID 15006973։ doi:10.1378/chest.125.3. ... 101,0 101,1 Shah R., Saltoun, C. A. (May-Jun 2012)։ «Chapter 14: Acute severe asthma (status asthmaticus)»։ Allergy and Asthma ...

https://hy.m.wikipedia.org/wiki/Բրոնխային_հեղձուկ

Air bubbles can leave the blood through the lungs. A patient with a right-to-left shunt is vulnerable to embolism from smaller ... Acute Care of at-Risk Newborns (ACoRN). *Pediatric basic life support (PBLS) ... One reason veins are preferred over arteries for intravascular administration is because the flow will pass through the lungs ... it is safer to insert with a relatively low risk of uncontrollable bleeding and essentially no risks of damage to the lungs or ...

https://en.wikipedia.org/wiki/Intravenous

Acute Lung Injury Treatment Market is expected to grow healthy rate in near future; Acute lung injury is observed as a part of ... Acute Lung Injury Treatment Market report presents a detailed overview of the present scope of growth for companies operating; ... systemic inflammatory process wherein the lung manifests symptoms similar to other tissues such as destruction in capillary ... Global Acute Lung Injury Market: Snapshot. Acute lung injury, a common condition characterized by acute severe hypoxia without ...

https://www.tmrresearch.com/acute-lung-injury-treatment-market

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence ... This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and ... Bacterial infections Hyperoxia LPS and bacterial pneumonia Transfusion-related acute lung injury Ventilator-induced lung injury ... Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are ...

https://link.springer.com/book/10.1007%2F978-3-319-46527-2

... reperfusion injury or acute lung injury (ALI) [1].. ALI and its more severe form acute respiratory distress syndrome (ARDS) are ... M. Cepkova and M. A. Matthay, "Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome," Journal of ... One pathological hallmark of acute lung injury and acute respiratory distress syndrome is the uncontrolled transmigration of ... "Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury," American ...

https://www.hindawi.com/journals/mi/2012/740987/

Clinical acute lung injury (ALI) is a major cause of acute respiratory failure in critically ill patients. There is ... Cytokine-mediated inflammation in acute lung injury.. Goodman RB1, Pugin J, Lee JS, Matthay MA. ... and anti-inflammatory cytokines play a major role in the pathogenesis of inflammatory-induced lung injury from sepsis, ... A recent multi-center clinical trial found that a lung-protective ventilatory strategy reduces mortality by 22% in patients ...

https://www.ncbi.nlm.nih.gov/pubmed/14563354?dopt=Abstract

Studies were searched in PUBMED by using the terms "extravascular lung water" (EVLW) and "acute lung injury" (ALI) or "acute ... Extravascular Lung Water and Acute Lung Injury. Ritesh Maharaj. Division of Intensive Care Medicine, Kings College Hospital, ... F. Michard, V. Zarka, S. Alaya, S. Sakka, and M. Klein, "Better characterization of acute lung injury/ARDS using lung water," ... Both experimental and clinical studies were searched in PUBMED using the term "extravascular lung water" and "acute lung injury ...

https://www.hindawi.com/journals/crp/2012/407035/

... acute respiratory distress syndrome (ARDS), is characterized by increased vascular and epithelial permeability, ... The pathophysiology of acute lung injury (ALI) and its most severe form, ... Microparticles and acute lung injury Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L364-81. doi: 10.1152/ajplung. ... The pathophysiology of acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), is ...

https://pubmed.ncbi.nlm.nih.gov/22728467/?dopt=Abstract

Transfusion related acute lung injury (TRALI) has been an upcoming cause of transfusion related mortality. It is characterized ... Acute Kidney Injury : Acute Liver Injury. 1419 Words , 6 Pages * Blood Transfusion And Transfusion Related Acute Lung Injury. ... Acute Treatment Of Acute Kidney Injury. 967 Words , 4 Pages Acute kidney injury (AKI, previously referred to as acute renal ... Acute Kidney Injury : Acute Liver Injury. 1419 Words , 6 Pages Prerenal Acute Kidney Injury Pathophysiology The human body has ...

https://www.bartleby.com/essay/Transfusion-Related-Acute-Lung-Injury-PKUJSVVKRZ3W

... , Transfusion Associated Acute Lung Injury, TRALI. ... Transfusion-Related Acute Lung Injury. Transfusion-Related Acute Lung Injury Aka: Transfusion-Related Acute Lung Injury, ... Transfusion-related acute lung injury, TRALI, Transfusion related acute lung injury (disorder), Transfusion related acute lung ... Results from immune mediated Neutrophil activation, endothelial injury, and capillary leak. *Acute Lung Injury is a result of ...

https://fpnotebook.com/hemeonc/Pharm/TrnsfsnRltdActLngInjry.htm

Studies of HPA axis activation and the role of relative adrenal insufficiency on the outcome of patients with acute lung injury ... relative adrenal insufficiency in patients with acute lung injury/ARDS is unknown. It is also unclear whether such a response, ... The National Heart, Lung, and Blood Institutes ARDS Network currently is testing the use of methylprednisolone in late ARDS. ... Previous Document: Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K.... ...

http://www.biomedsearch.com/nih/Glucocorticoids-acute-lung-injury/12682449.html

NIOSH-Author; Toxic-effects; Laboratory-animals; Leather-finishing; Chemical-composition; Fluorocarbons; Lung-disease; ...

https://www.cdc.gov/niosh/nioshtic-2/00237833.html

Find facts about lung diseases, such as lung cancer, COPD, asthma. ... Learn how to improve your lung health. Make efforts towards clean air and smokefree living. ... What is LUNG FORCE?. LUNG FORCE unites women and their loved ones across the country to stand together in the fight against ... American Lung Association , 1-800-LUNGUSA (1-800-586-4872)1-800-LUNGUSA , Submit A Question , Live Chat ...

http://www.lung.org/our-initiatives/research/meet-the-research-team/acute-lung-injury.html

... has shown that adult stem cells from bone marrow can help treat acute lung injury. Acute lung ... Acute lung injury? Stem cell therapy may help - Oct 30, 2009. *Bone marrow stem-cell therapy could treat acute lung injury: ... Acute lung injury (ALI) can be caused by any major inflammation or injury to the lungs and is a major cause of death in ... Tags: acute lung injury, adult stem cells, air sacs, blood vessels, bone marrow, cause of death, cd34, cell population, chicago ...

http://www.thaindian.com/newsportal/health/stem-cell-therapy-holds-promise-for-acute-lung-injury_100267100.html

1.9M grant to study two proteins that play roles in acute lung injury, a condition which affects thousands of people each year. ... URMC receives $1.9M to study acute lung injury. Mar. 31, 2017 ... to identify viable therapies that will limit acute lung injury ... ALI occurs when capillary-alveolar barriers in the lung are disrupted, resulting in a variety of dangerous symptoms that can ... Fazals current study aims to understand how BiP and mortalin control the proinflammatory and leaky phenotype of the lung, and ...

https://www.urmc.rochester.edu/news/publications/strong-kids/urmc-receives-$1-9m-to-study-acute-lung-injury

Acute Lung Injury. Lung Injury. Lung Diseases. Respiratory Tract Diseases. Respiration Disorders. Infant, Premature, Diseases. ... Critical Illness Sleep Acute Lung Injury Acute Respiratory Distress Syndrome Drug: Dexmedetomidine Drug: Midazolam and Fentanyl ... Critically ill patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) who receive mechanical ... on sleep and inflammation in critically ill patients with Acute Lung Injury and Acute Respiratory Disorder Syndrome (ALI/ARDS ...

https://clinicaltrials.gov/ct2/show/NCT01050699?term=respiratory+distress+syndrome+OR+surfactant+deficiency&recr=Open&fund=01&rank=9

... renal disease and acute lung injury. In the current study, we report that ACE2 could mediate the severe acute lung injury ... virus-induced acute lung injury and suggest that might be a useful potential therapeutic target for future influenza A (H7N9) ... which is a severe form of acute lung injury (ALI) that further contributes to morbidity. To date, no effective drugs that ... Although most infections resulted in respiratory illness, some severe cases resulted in acute respiratory distress syndrome ( ...

https://www.nature.com/articles/srep07027?error=cookies_not_supported&code=8852b124-7b2e-4214-adc2-bf71a5852fdb

Velvet antler may prevent acute lung injury. Thursday, August 23, 2018 by: Edsel Cook Tags: acute lung injury, deer, dietary ... www.naturalnews.com/2018-08-23-velvet-antler-may-prevent-acute-lung-injury.html",Velvet antler may prevent acute lung injury,/a ... Acute lung injury (ALI) is a clinical condition where lung tissue is deprived of oxygen by conditions not involving ... Velvet antler may prevent acute lung injury. Herbal remedy that was effective against SARS found to be beneficial for acute ...

https://naturalnews.com/2018-08-23-velvet-antler-may-prevent-acute-lung-injury.html

... lung edema, extended lung destruction (lung injury scores and lung histology), neutrophil recruitment in the lung, and cytokine ... Keywords: acid aspiration, ARDS, glutamine, ventilator-induced lung injury. Acute respiratory distress syndrome (ARDS) is a ... After ventilator use for 4 h, high TV resulted in greater lung injury physiologic and biologic indices. Compared with vehicle ... on a two-hit model for VILI after acid aspiration-induced lung injury in rats. Rats were intratracheally challenged with ...

https://lifeboat.com/blog/2020/04/glutamine-attenuates-acute-lung-injury-caused-by-acid-aspiration

... associated acute lung injury (ALI) accounts for about 70% mortality of SAP patients. However, there are no precise biomarkers ... Gamma-enolase predicts lung damage in severe acute pancreatitis-induced acute lung injury. ... Severe acute pancreatitis (SAP) associated acute lung injury (ALI) accounts for about 70% mortality of SAP patients. However, ... Severe acute pancreatitis-induced acute lung injury Alpha-enolase Gamma-enolase Sprague-Dawley rats ...

https://link.springer.com/article/10.1007%2Fs10735-018-9774-3

Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion.. Shasby DM, Fox RB, Harada RN, Repine JE. ... Increased numbers of granulocytes are found in lungs acutely injured by hyperoxia, but their contribution to lung injury ... exposure to hyperoxia for 72 h resulted in fewer granulocytes in lung lavages and less edematous lung injury. In contrast, when ... increased numbers of granulocytes were found in lung lavages and the degree of edematous lung injury increased to levels not ...

https://www.ncbi.nlm.nih.gov/pubmed/7096148?dopt=Abstract

... this months Anesthesiology highlights the potential of cell-based therapies for the treatment of acute lung injury and acute ... "Acute lung injury and acute respiratory distress syndrome continue to be major causes of death in seriously ill patients," said ... Lam, however, emphasized that more animal studies need to be performed before EPC transplantation for acute lung injury can be ... Lam further explained that several pharmacologic agents have been examined in the management of acute lung injury over the past ...

https://www.newswise.com/articles/new-acute-lung-injury-study-finds-benefits-of-autologous-cell-transplantation-therapy

Caloric restriction failed to improve outcomes in ventilator-dependent patients with acute lung injury, results of an NIH- ... The findings came from the Early Versus Delayed Enteral Feeding to Treat People with Acute Lung Injury or Acute Respiratory ... The EDEN Study involved 1,000 adults with acute lung injury or acute respiratory distress requiring ventilator support. ... Source Reference: Rice TW, et al "Initial trophic vs full enteral feeding in patients with acute lung injury. The EDEN ...

https://www.medpagetoday.com/meetingcoverage/sccm/31024

Adult stem cells from bone marrow can help treat acute lung injury, a new mice study by researchers at the University of ... Acute lung injury (ALI) can be caused by any major inflammation or injury to the lungs and is a major cause of death in ... Adult stem cells from bone marrow can help treat acute lung injury, a new mice study by researchers at the University of ... The researchers hope to explore the possibility of using stem cell therapy in human acute lung injury. Their results are ...

http://www.medindia.net/news/Acute-Lung-Injury-may-be-Treated-With-Stem-Cell-Therapy-60241-1.htm

Requirement and role of C5a in acute lung inflammatory injury in rats.. M S Mulligan, E Schmid, B Beck-Schimmer, G O Till, H P ... In C6-deficient rats, CVF infusion caused the same level of lung injury (measured by leak of 125I-albumin) as found in C6- ... In the IgG immune complex model of lung injury, anti-C5a administered intratracheally (but not intravenously) reduced in a dose ... Polyclonal antibody to rat C5a was used to define the requirements for C5a in neutrophil-dependent inflammatory lung injury ...

https://www.jci.org/articles/view/118818

Transfusion-related acute lung injury (TRALI) is a serious blood transfusion complication characterized by the acute onset of ... It is often impossible to distinguish TRALI from acute respiratory distress syndrome (ARDS). The typical presentation of TRALI ...

https://en.wikipedia.org/wiki/Transfusion-related_acute_lung_injury

Similarly, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are regularly encountered and potentially ... Bersten AD, Edibam C, Hunt T, Moran J. Incidence and mortality of acute lung injury and the acute respiratory distress syndrome ... Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory ... Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress ...

https://www.rtmagazine.com/disorders-diseases/critical-care/ards/obesity-and-acute-lung-injury/

... 25.05.2005 ... Female lung transplant recipients are significantly more likely to suffer from a type of injury to the transplanted lung called ... When the lung is transplanted into the recipient and all the blood vessels are reattached, injury to the lung may become ... which is an acute severe lung injury that occurs within the first 72 hours after the transplant and has a high mortality. Once ...

http://www.innovations-report.com/html/reports/medicine-health/report-44702.html

... including acute lung injury and the acute respiratory distress syndrome, chronic obstructive lung disease, and cystic fibrosis ... Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Am J Respir Cell Mol Biol. 2009 May ... In the lung, such inflammatory damage is believed to contribute to the pathogenesis of diverse lung diseases, ... of the epithelial cells to the itinerant leukocytes and their cytotoxic products and the consequences of this for lung injury ...

https://pubmed.ncbi.nlm.nih.gov/18978300/?dopt=Abstract

Homeostatic and early-recruited CD101− eosinophils suppress endotoxin-induced acute lung injury Chen Zhu, Qing-Yu Weng, Ling- ... Increase in circulating ACE-positive endothelial microparticles during acute lung injury Yusuke Takei, Mitsuhiro Yamada, Koji ... Diagnosis and outcome of acute respiratory failure in immunocompromised patients after bronchoscopy Philippe R. Bauer, Sylvie ... Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure Bram Rochwerg, Laurent ...

https://erj.ersjournals.com/collection/acute-lung-injury-and-critical-care

Lung Injury. Acute Lung Injury. Lung Diseases. Respiratory Tract Diseases. Respiration Disorders. Infant, Premature, Diseases. ... Acute Respiratory Distress Syndrome (ARDS) and a lesser condition that occurs prior to ARDS, Acute Lung Injury (ALI), are ... Acute Lung Injury. Acute Respiratory Distress Syndrome. Albuterol. Aerosolized. Critical Care. Ventilator. ... enhance clearance of lung edema and decrease pulmonary inflammation in patients with acute lung injury. Because beta-2 agonists ...

https://www.clinicaltrials.gov/ct2/show/NCT00434993?term=ALBUTEROL&rank=78

... induced acute tracheobronchial epithelial injury and its relationship to granulocyte emigration were studied in monkeys. Male ... Ozone-induced acute tracheobronchial epithelial injury: relationship to granulocyte emigration in the lung.. ... Ozone (10028156) (O3) induced acute tracheobronchial epithelial injury and its relationship to granulocyte emigration were ... Irritant-gases; In-vivo-studies; Lung-irritants; Histology; Laboratory-animals; Inhalation-studies; Lung-cells; Immune-reaction ...

https://www.cdc.gov/niosh/nioshtic-2/00228725.html

Respiratory Failure during Pregnancy Synonyms ARDS (acute respiratory distress syndrome) during pregnancy ALI (acute lung injury) during pregnancy Ventilatory failure during pregnancy Severe pneumonia during pregnancy Pulmonary embolus (PE) during pregnancy Amniotic fluid embolus Related Conditions Status asthmaticus during pregnancy Mechanical ventilation during pregnancy 1. (thecardiologyadvisor.com)
Prone positioning (PP) in non-COVID-19 acute respiratory distress syndrome (ARDS) has an established evidence base, particularly in intubated and mechanically ventilated (IMV) patients. (rcpjournals.org)
Patients admitted to the intensive care unit (ICU) with acute respiratory distress syndrome (ARDS) suffer from profound weight loss while hospitalized and have nutritional related residual effects up to a year post-discharge. (grantome.com)
The nutritional care provided to ARDS patients typically consists of enteral nutrition (EN) while mechanically ventilated followed by a general diet when weaned from the ventilator. (grantome.com)
Cerebral malaria (CM) and malaria-associated acute lung injury/acute respiratory distress syndrome (MA-ALI/ARDS) are among the most severe complications of Plasmodium infection. (reading.ac.uk)
For a minority of subjects, the disease worsens approximately 5-10 days after symptom onset, resulting in complications such as acute respiratory distress syndrome (ARDS) and other organ failure. (ingenewpharma.com)

Cannabidiol reduced swelling and enhanced lung features in a murine design of acute lung injury. (medprocannabis.com)
Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria. (reading.ac.uk)
Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. (vanderbilt.edu)

Serje J. Exogenous surfactant preserve lung function and reduces alveolar Evans blue dye in flux in a rat model of ventilation-induced lung injury. (medigraphic.com)
Prevention of intracellular adenosine triphosphate depletion after subletal oxidant injury to rat tipe II alveolar epithelial cells with exogenous glutation and N-acetylcisteine. (medigraphic.com)
Surfactant protein A (SP-A) levels was measured by ELISA method and also Alveolar macrophages population percentages were measured by using Stereology of lung tissue method before and after the training program. (ac.ir)

While acute lung injury (ALI) and pulmonary edema are feared COVID-19 complications, many patients present with elevated cardiac biomarkers and evidence of left ventricular (LV) dysfunction," said Dr. McCants. (yankeepr.com)

Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial. (vanderbilt.edu)

As a clinician, Dr. Shanley specializes in the treatment of children with hypoxemic respiratory failure from acute lung injury and severe sepsis triggered by infection. (luriechildrens.org)

Is it safe to prescribe benzodiazepines or opioids for dyspnoea in interstitial lung disease? (ersjournals.com)

I have been a critical care nurse for over 25 years starting in the neuro-trauma critical care unit at R Adams Cowley Shock Trauma in Baltimore, MD. My current focus is critical care research both clinically and scientifically with a concentration in mechanical ventilation and understanding the pathophysiology of acute lung injury, acute respiratory distress syndrome and ventilator induced/associated lung injury. (aprvnetwork.org)
The time-controlled adaptive ventilation protocol: mechanistic approach to reducing ventilator-induced lung injury. (aprvnetwork.org)
Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI). (aprvnetwork.org)
Myocardial infarction, ventilator-induced acute lung injury, neuronal apoptosis, cognitive impairment and other inflammatory models. (ingenewpharma.com)

Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal acute lung injury (ALI) by driving hypercytokinemia and aggressive inflammation through mechanisms that remain elusive. (vaccinereport.org)
The runaway response can feel like inflammation of your airways, a high fever, and way too much mucus in your lungs. (prdistribution.com)
In mouse models of lung injury, CBD reduced lipopolysaccharide-induced acute pulmonary inflammation . (prdistribution.com)
Note how hesperidin has been reported to regulate these cytokines in experiments where severe inflammation was induced to affect the heart, lungs and brain. (ingenewpharma.com)
Using LPS, a component of the cell wall of gram-negative bacteria as an inflammatory agent, they showed the application of CBD resulted in decreased pulmonary inflammation and improvements in lung function in mouse models of inflammatory lung disease[ref]Ribeiro A, Almeida VI, Costola-de-souza C, et al. (medicalmarijuana.co.uk)
Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. (medicalmarijuana.co.uk)

Background and Aims: Between March 2019 and February 2020, there was an outbreak of acute lung injury associated with vaping tetrahydrocannabinol (THC), contaminated with vitamin E acetate, in the United States. (drugsandalcohol.ie)

Coronaviruses cause the common cold and more severe diseases, such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). (vitamindwiki.com)
The same association was noted for its predecessors, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). (yankeepr.com)
The team pointed to data procured from the severe acute respiratory syndrome (SARS) epidemic of 2003, which most prominently affected persons in their 30s and 40s-despite these younger patients reporting lower disease severity and risk of mortality versus older people with pre-existing conditions. (practicalcardiology.com)

Serum surfactant protein-A levels in patients with acute cardiogenic pulmonary edema and adult respiratory distress syndrome. (medigraphic.com)
Effect of the dialysis membrane in the treatment of patients with acute renal failure. (vanderbilt.edu)

Dr. McVerry is a pulmonologist and critical care physician whose research interest is focused on translational investigation of the biological mechanisms underlying the development and consequences of sepsis and acute lung injury. (zmescience.com)
This belief, they wrote, aligns with evidence of angiotensin II antagonists benefitting sepsis-associated acute lung injury. (practicalcardiology.com)

To study the role of the protective effect of N-acetylcisteine and exogenous surfactant on the acute pulmonary injury (API) induced by oxygen. (medigraphic.com)
Mechanical ventilation (MV) can induce lung oxidative stress, which plays an important role in pulmonary injury. (unesp.br)

Complementary proteomic and genetic experiments identify a possible therapeutic strategy for acute myeloid leukemia. (sciencemag.org)
In the present review, we will describe the pathophysiological aspects of acute lung injury induced by combined burn and smoke inhalation and examine various therapeutic approaches. (symptoma.mt)

Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress Hidetoshi Tsuda, Noritaka Kawada, Jun-ya Kaimori, Harumi Kitamura, Toshiki Moriyama, Hiromi Rakugi, Shiro Takahara, Yoshitaka Isaka Biochemical and Biophysical. (nwlifescience.com)
8 Bucillamine has also been shown to prevent oxidative and reperfusion injury in heart and liver tissues 8 and is highly cell permeable for efficient delivery into cells. (revivethera.com)
Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. (vanderbilt.edu)

Initial case reports of vaping-related lung injury date back to 2012, but the ongoing outbreak of EVALI began in the summer of 2019 and has been implicated in 2,807 cases and 68 deaths as of this writing. (stanford.edu)

Are isofurans and neuroprostanes increased after subarachnoid hemorrhage and traumatic brain injury? (vanderbilt.edu)

Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness. (vanderbilt.edu)

of Johns Hopkins School of Medicine, the National Institute on Aging and National Institutes of Health-called for the urgent expansion of renin-angiotensin system (RAS)-based intervention assessment as part of the need for clinical understanding as to how lung complications are driving novel coronavirus (COVID-19) mortality worldwide. (practicalcardiology.com)

Prone positioning improves oxygenation via better ventilation-to-perfusion matching and improved lung mechanics while reducing the potential for ventilator-associated lung injury. (elsevier.com)
Arnold, John H. / The prone position in acute lung injury . (elsevier.com)
Patients with activated immune systems may be prone to the acute lung injury sometimes seen after transfusions, but platelet-directed therapies may help. (sciencemag.org)

Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. (hku.hk)

Protection of acute lung injury due to oxygen exposure with N-acetylcisteine and exogenous surfactant in rats. (medigraphic.com)
Antioxidant-surfactant mitigate hyperoxic lung injury in premature rabbits. (medigraphic.com)

Lungs from the HSR group rats treated with or without biliverdin (BV) were excised 12 h after resuscitation and lung wet/dry ratio was measured. (figshare.com)
The age-associated decrease of ACE2 expression, which investigators have observed in the lungs of rats, is in line with "a constellation of major proinflammatory changes perpetrated by an age-associated increase in RAS signaling throughout the body," the team wrote. (practicalcardiology.com)

The common findings in thoracic high-resolution computed tomography in NSIP are bilateral reticular opacities, traction bronchiectasis, reduced volume of the lobes, and ground-glass opacity in the lower lungs. (e-trd.org)
These lesions can involve diffuse bilateral lungs or subpleural area. (e-trd.org)

7 Studies in human cells and animal models have shown that NAC works to prevent acute lung injury caused by influenza virus infection through inhibition of these ROS-mediated mechanisms. (revivethera.com)
It is also reasonable to hypothesize that similar processes related to ROS are involved in acute lung injury during nCov-19 infection, possibly justifying the investigation of bucillamine as an intervention for COVID-19. (revivethera.com)

Recent findings support the hypothesis that a preclinical lung injury characterized by an enhanced inflammatory response is present in potential donors and may predispose recipients to an adverse clinical prognosis following lung transplantation. (nih.gov)

Lung wet/dry ratio after hemorrhagic shock and resuscitation (HSR). (figshare.com)

Although evidence supports immunomodulatory treatment for myocardial injury associated with severe influenza, there is not yet an evidence-based approach to treat the cytokine milieu associated with COVID-19 and the immunologic storm associated with systemic inflammatory response syndrome (SIRS). (yankeepr.com)
All smoke irritates the lungs and aggravates COPD, but vaporized or ingested cannabis could potentially provide many benefits because of its anti-inflammatory, immunosuppressant, and bronchodilating (airway opening) qualities. (medicalmarijuana.co.uk)

The patient presented 2 months after his injury with progressive stridor and dyspnea necessitating tracheostomy. (symptoma.mt)
See: carbon monoxide Symptoms Patients who have suffered smoke inhalation injury may complain of dyspnea , cough, and black sputum. (symptoma.mt)
Other findings such as conjunctivitis, stridor, dyspnea , disorientation, obtundation and coma are also indicative of inhalation injury. (symptoma.mt)

Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 3. (e-trd.org)
Lee, Kim, Kang, Jegal, Park, and on behalf of Korean Interstitial Lung Diseases Study Group: Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 3. (e-trd.org)
Diagnosis of inhalation injury should be suspected in patients with facial burns , singed nasal hair, cough, carbonaceous sputum, or evidence of upper airway edema, including hoarseness, stridor, or wheezing. (symptoma.mt)

Acute exacerbations are acute, clinically significant deteriorations of unidentifiable cause in patients with underlying IPF. (insightsinipf.com)

The ongoing U.S. outbreak of vaping-related acute lung injury, recently named EVALI (E-cigarette or vaping product use associated acute lung injury), has reignited concerns about the health effects of vaping. (stanford.edu)

EN is a medical intervention that has risks and cost yet no studies have demonstrated its efficacy in this population. (grantome.com)

Isofurans: novel products of lipid peroxidation that define the occurrence of oxidant injury in settings of elevated oxygen tension. (vanderbilt.edu)

There is an urgent need to monitor and manage myocardial injury during hospitalization for severely or critically ill COVID-19 patients," said Octapharma USA President Flemming Nielsen. (yankeepr.com)

Ischemia-Reperfusion Injury during Ascending Aortic Surgery: Comparative Effects of Deferoxamine and N-Acetylcysteine as Antioxidants Maged S. Abdallah MD, Osama M. Assad MD, Tarek Al Taweel MD, Ahmed Gaafar MD, Dalia A, Labib MD Journal of The. (nwlifescience.com)

A comparison of external fixation and locked intramedullary nailing in the treatment of femoral diaphysis fractures from gunshot injuries. (surgery.by)
Although smoked cannabis also has this effect, any kind of combustion creates other lung irritants that would be counterproductive for COPD treatment. (medicalmarijuana.co.uk)
Revive has a history in the clinical development with Bucillamine in the treatment of acute gout flares and cystinuria, and we will advance our efforts in reviving and exploring new uses of Bucillamine for unmet medical needs. (revivethera.com)

The two primary forms of COPD are chronic bronchitis , which produces a long-term cough with mucus, and emphysema , which leads to the progressive deterioration of the alveoli, the air sacs that allow for gaseous exchange in the lungs. (medicalmarijuana.co.uk)

Limiting ventilator-associated lung injury in a preterm porcine neonatal model. (aprvnetwork.org)

The effects of airway pressure release ventilation on respiratory mechanics in extrapulmonary lung injury. (aprvnetwork.org)
Preemptive mechanical ventilation can block progressive acute lung injury. (aprvnetwork.org)
Airway pressure release ventilation reduces conducting airway micro-strain in lung injury. (aprvnetwork.org)

Those with COPD have a heightened immune response in the lungs and compounds in cannabis can lead to immunosuppression. (medicalmarijuana.co.uk)

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. (vanderbilt.edu)

Exposure to silica dust from cutting, grinding or polishing product can cause acute lung injury or cancer. (tilebuys.com)

Anatomy16

Organisms9

Diseases62

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes30

Disciplines and Occupations1

Information Science6

Health Care22

Transfusion related acute lung injury (TRALI) caused by red blood cell transfusion involving residual plasma anti-HLA antibodies: a report on two cases and general considerations. (1/1061)

Mechanisms of pulmonary dysfunction after on-pump and off-pump cardiac surgery: a prospective cohort study. (2/1061)

Toward early identification of acute lung injury in the emergency department. (3/1061)

Keratinocyte growth factor protects against Clara cell injury induced by naphthalene. (4/1061)

NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells. (5/1061)

Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury. (6/1061)

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. (7/1061)

Predictors of mortality in acute lung injury during the era of lung protective ventilation. (8/1061)

Acute Lung Injury

Lung Injury

Respiratory Distress Syndrome, Adult

Lung

Lung Diseases

Ventilator-Induced Lung Injury

Pulmonary Edema

Bronchoalveolar Lavage Fluid

Respiration, Artificial

Wounds and Injuries

Pulmonary Alveoli

Hyperoxia

Extravascular Lung Water

Tidal Volume

Pneumonia

Smoke Inhalation Injury

Pulmonary Gas Exchange

Positive-Pressure Respiration

Disease Models, Animal

Blood-Air Barrier

Neutrophils

Capillary Permeability

Lipopolysaccharides

Peroxidase

Brain Injuries

Reperfusion Injury

Mice, Inbred C57BL

Liquid Ventilation

Neutrophil Infiltration

Hydrochloric Acid

Bronchoalveolar Lavage

Sepsis

Lung Neoplasms

Macrophages, Alveolar

Ventilators, Mechanical

Lung Compliance

Respiratory Mechanics

Acute Disease

Athletic Injuries

Blood Gas Analysis

Bleomycin

Spinal Cord Injuries

Respiratory Mucosa

Pulmonary Circulation

Oleic Acid

Prone Position

Pulmonary Fibrosis

Pulmonary Surfactants

Lung Volume Measurements

Rats, Sprague-Dawley

Chemokine CXCL2

Pneumonia, Aspiration

Lung Transplantation

Inflammation

Blood Transfusion

Oxygen

Injury Severity Score

Shock, Hemorrhagic

Cytokines

Mice, Knockout

Neutrophil Activation

Tumor Necrosis Factor-alpha

Intensive Care Units

Administration, Inhalation

APACHE

High-Frequency Ventilation

Time Factors

Inflammation Mediators

Carcinoma, Non-Small-Cell Lung

Epithelial Cells

Endotoxins

Interleukin-6

Fluorocarbons

Endotoxemia

Leg Injuries

Acute Kidney Injury

Respiratory Dead Space

One-Lung Ventilation

Nitrosomethylurethane

Blood Component Transfusion