A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Pathological processes involving any part of the LUNG.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
An abnormal increase in the amount of oxygen in the tissues and organs.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
Infection of the lung often accompanied by inflammation.
Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. PULMONARY GAS EXCHANGE occurs across this membrane.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Artificial respiration (RESPIRATION, ARTIFICIAL) using an oxygenated fluid.
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Tumors or cancer of the LUNG.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
Mechanical devices used to produce or assist pulmonary ventilation.
The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Disease having a short and relatively severe course.
Injuries incurred during participation in competitive or non-competitive sports.
Measurement of oxygen and carbon dioxide in the blood.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
The circulation of the BLOOD through the LUNGS.
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
The posture of an individual lying face down.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.
A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.
The transference of either one or both of the lungs from one human or animal to another.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Hospital units providing continuous surveillance and care to acutely ill patients.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
Ventilatory support system using frequencies from 60-900 cycles/min or more. Three types of systems have been distinguished on the basis of rates, volumes, and the system used. They are high frequency positive-pressure ventilation (HFPPV); HIGH-FREQUENCY JET VENTILATION; (HFJV); and high-frequency oscillation (HFO).
Elements of limited time intervals, contributing to particular results or situations.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
General or unspecified injuries involving the leg.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
That part of the RESPIRATORY TRACT or the air within the respiratory tract that does not exchange OXYGEN and CARBON DIOXIDE with pulmonary capillary blood.
Techniques for supplying artificial respiration to a single lung.
An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
A disease or state in which death is possible or imminent.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.
The number of times an organism breathes with the lungs (RESPIRATION) per unit time, usually per minute.
The force per unit area that the air exerts on any surface in contact with it. Primarily used for articles pertaining to air pressure within a closed environment.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Health care provided to a critically ill patient during a medical emergency or crisis.
Drugs used for their effects on the respiratory system.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A pathological condition manifested by failure to perfuse or oxygenate vital organs.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
Burns of the respiratory tract caused by heat or inhaled chemicals.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)
Substances that reduce or suppress INFLAMMATION.
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
General or unspecified injuries to the chest area.
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
Inflammation of the lung parenchyma that is caused by bacterial infections.
General or unspecified injuries involving organs in the abdominal cavity.
The dialdehyde of malonic acid.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Relatively complete absence of oxygen in one or more tissues.
General or unspecified injuries involving the arm.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
General or unspecified injuries to the hand.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A greenish-yellow, diatomic gas that is a member of the halogen family of elements. It has the atomic symbol Cl, atomic number 17, and atomic weight 70.906. It is a powerful irritant that can cause fatal pulmonary edema. Chlorine is used in manufacturing, as a reagent in synthetic chemistry, for water purification, and in the production of chlorinated lime, which is used in fabric bleaching.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Hospital units providing continuous surveillance and care to acutely ill infants and children. Neonates are excluded since INTENSIVE CARE UNITS, NEONATAL is available.
Epithelial cells that line the PULMONARY ALVEOLI.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Injuries involving the vertebral column.
A fibroblast growth factor that is a specific mitogen for EPITHELIAL CELLS. It binds a complex of HEPARAN SULFATE and FIBROBLAST GROWTH FACTOR RECEPTOR 2B.
A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.
Injuries to the knee or the knee joint.
A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
The measurement of an organ in volume, mass, or heaviness.
Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
General or unspecified injuries to the heart.
Liquid components of living organisms.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.
A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
Classification system for assessing impact injury severity developed and published by the American Association for Automotive Medicine. It is the system of choice for coding single injuries and is the foundation for methods assessing multiple injuries or for assessing cumulative effects of more than one injury. These include Maximum AIS (MAIS), Injury Severity Score (ISS), and Probability of Death Score (PODS).
An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
The relationship between the dose of an administered drug and the response of the organism to the drug.
Bleeding or escape of blood from a vessel.
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.
A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.
General or unspecified injuries to the soft tissue or bony portions of the face.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
A type of shock that occurs as a result of a surgical procedure.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.
The natural enzymatic dissolution of FIBRIN.
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Transfusion related acute lung injury (TRALI) caused by red blood cell transfusion involving residual plasma anti-HLA antibodies: a report on two cases and general considerations. (1/1061)

TRALI is considered a serious hazard among immune complications of blood transfusion and its occurrence is admitted to be globally underestimated. Each type of blood product is likely to cause TRALI. We report here on two consecutive observations of TRALI caused by red blood cell concentrates, in which anti-HLA class I and class II antibodies resulting from post-gravitational allo-immunization were evidenced in donors. HLA class I and II antigenic community between recipients and donors' husbands were found and strong reacting IgG antibodies directed at several of those common antigens were detected in the donors' serum. Both donors had more than 3 pregnancies, raising the issue of blood donor selection or of plasma reduction for cellular products.  (+info)

Mechanisms of pulmonary dysfunction after on-pump and off-pump cardiac surgery: a prospective cohort study. (2/1061)

BACKGROUND: Pulmonary dysfunction following cardiac surgery is believed to be caused, at least in part, by a lung vascular injury and/or atelectasis following cardiopulmonary bypass (CPB) perfusion and collapse of non-ventilated lungs. METHODS: To test this hypothesis, we studied the postoperative pulmonary leak index (PLI) for 67Ga-transferrin and (transpulmonary) extravascular lung water (EVLW) in consecutive patients undergoing on-pump (n = 31) and off-pump (n = 8) cardiac surgery. We also studied transfusion history, radiographs, ventilatory and gas exchange variables. RESULTS: The postoperative PLI and EVLW were elevated above normal in 42 and 29% after on-pump surgery and 63 and 37% after off-pump surgery, respectively (ns). Transfusion of red blood cell (RBC) concentrates, PLI, EVLW, occurrence of atelectasis, ventilatory variables and duration of mechanical ventilation did not differ between groups, whereas patients with atelectasis had higher venous admixture and airway pressures than patients without atelectasis (P = 0.037 and 0.049). The PLI related to number of RBC concentrates infused (P = 0.025). CONCLUSION: The lung vascular injury in about half of patients after cardiac surgery is not caused by CPB perfusion but by trauma necessitating RBC transfusion, so that off-pump surgery may not afford a benefit in this respect. However, atelectasis rather than lung vascular injury is a major determinant of postoperative pulmonary dysfunction, irrespective of CPB perfusion.  (+info)

Toward early identification of acute lung injury in the emergency department. (3/1061)

BACKGROUND: There are no studies evaluating the epidemiology of pediatric acute lung injury (ALI) in the emergency department (ED), where early identification and interventions are most likely to be helpful. The purpose of this study was to describe the epidemiology of the ALI precursor acute hypoxemic respiratory failure (AHRF) in the ED. METHODS: We analyzed 11,664 pediatric patient records from 16 EDs. Records were selected if oxygen saturation (SpO(2)) was recorded during the visit. Virtual partial pressure of oxygen (pO(2)) was calculated from SpO(2), thus allowing calculation of ratios of pO(2) to fraction of inspired oxygen (FiO(2)) (PFRs). Patients with a PFR < 300 were classified as having AHRF. Univariate analyses and logistic regression were used to test the association of clinical factors with the presence of AHRF and intubation. RESULTS: AHRF criteria (ie, PFR < 300) were met in 121 (2.9%) of the 4,184 patients with an oxygenation measurement. The following variables were independently associated with ALI: higher Pediatric Risk of Admission II score (adjusted odds ratio [95% confidence interval (CI)] = 1.12 [1.08-1.16]; p < .001), higher heart rate (1.02 [1.01-1.03]; p = .009), a positive chest radiograph (2.35 [1.02-5.43]; p = .045), and lower temperature (0.49 [0.36-0.68]; p < .001).The final model had an R(2) = .20. CONCLUSION: We found nonintubated AHRF to be prevalent in the ED. The low R(2) for the regression model for AHRF underscores the lack of criteria for early identification of patients with respiratory compromise. Our findings represent an important first step toward establishing the true incidence of ALI in the pediatric ED.  (+info)

Keratinocyte growth factor protects against Clara cell injury induced by naphthalene. (4/1061)


NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells. (5/1061)


Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury. (6/1061)


Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. (7/1061)


Predictors of mortality in acute lung injury during the era of lung protective ventilation. (8/1061)


Recipient factors,ref,Vlaar AP, et al. Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Crit Care Med. 2007;176:886,/ref,,ref,Gajic O, et al. Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med. 2007;176:886,/ref,,ref name=fifteen,Toy P, et al. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012;119:1757,/ref,,ref,Benson AB, et al. Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding. Intensive Care Med. 2010;36:1710,/ref ...
Non-critically ill with TRALI - 5-7% ,ref,Looney MR, et al. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury. Crit Care Med. 2014;42:1676,/ref,,ref,Popovsky MA, et al. Transfusion-related acute lung injury: a neglected serious complication of hemotherapy. Transfusion. 1992;32:589,/ref,,ref,Sillman CC, et al. Transfusion-related acute lung injury (TRALI): current concepts and misconceptions. Blood Rev. 2009;23:245,/ref ...
Data & statistics on Acute Lung Injury: MRNA expression of Interleukin-8 in bronchoalveolar lavage fluid cells before injury and after injury. NG, acute lung injury with normoglycemia group; HG, acute lung injury with hyperglycemia group; HG-VI, acute lung injury with hyperglycemia treated with intravenous insulin group; HG-AI, acute lung injury with hyperglycemia treated with aerosolized insulin group; IL-8, interleukin-8. Boxes extend ..., Particle-induced acute lung injury. Results obtained from analysis performed on bronchoalveolar lavage fluid samples recovered from animals at 24 h post-exposure. Animals were exposed by intratracheal instillation to: saline ( E); OFA100 ( C); OFA400 (P); ROFA#6 ( 1); or ARD ([). Various biomarkers of acute lung injury were assessed such as: A) edema/secretory activity (protein/mL); B) edema (albumin/mL); ..., Inhaltsverzeichnis Einleitung Hypothesen Theoretische Grundlagen der Hypothesen Patienten und Methodik Patienten Pneumonie Acute lung injury / Acute
Request for Free Sample Report: https://www.delveinsight.com/sample-request/acute-lung-injury-market. Table of Contents:. 1. Key Insights. 2. Executive Summary of Acute Lung Injury. 3. Competitive Intelligence Analysis for Acute Lung Injury. 4. Acute Lung Injury: Market Overview at a Glance. 5. Acute Lung Injury: Disease Background and Overview. 6. Patient Journey. 7. Acute Lung Injury Epidemiology and Patient Population. 8. Treatment Algorithm, Current Treatment, and Medical Practices. 9. Unmet Needs. 10. Key Endpoints of Acute Lung Injury Treatment. 11. Marketed Products. List to be continued in report. 12. Emerging Therapies. List to be continued in report. 13. Acute Lung Injury: Seven Major Market Analysis. 14. Attribute analysis. 15. 7MM: Market Outlook. 16. Access and Reimbursement Overview of Acute Lung Injury. 17. KOL Views. 18. Market Drivers. 19. Market Barriers. 20. Appendix. 21. DelveInsight Capabilities. 22. Disclaimer. 23. About DelveInsight. About DelveInsight ...
Transfusion-related acute lung injury is emerging as a common cause of transfusion-related adverse events. However, awareness about this entity in the medical fraternity is low and it, consequently, remains a very under-reported and often an under-diagnosed complication of transfusion therapy. We report a case of a 46-year old woman who developed acute respiratory and hemodynamic instability following a single unit blood transfusion in the postoperative period. Investigation results were non-specific and a diagnosis of transfusion-related acute lung injury was made after excluding other possible causes of acute lung injury. She responded to symptomatic management with ventilatory and vasopressor support and recovered completely over the next 72 hours. The diagnosis of transfusion-related acute lung injury relies on excluding other causes of acute pulmonary edema following transfusion, such as sepsis, volume overload, and cardiogenic pulmonary edema. All plasma containing blood products have been
Transfusion-Related Acute Lung Injury (TRALI) is an important life-threatening complication that is related with blood transfusion. The frequency is reported as 1/5.000. It is generally characterized with hypoxia that appears at the 2-6th hours after the blood transfusion, bilateral infiltration in the chest radiography, and non-cardiogenic pulmonary edema. Acute respiratory distress, hypotension, tachycardia and fever accompany the clinical picture. Past surgery, blood transfusion, and sepsis are among the factors that trigger the disease. In this study, the efficiency of the hemodialysis applied in the right time in the treatment of a heavy TRALI case developed after a blood transfusion has been presented.. Keywords: Acute lung injury, efficiency, hemodialysis, ...
Medical information, Acute lung injury. Definition of Acute lung injury, symptoms of Acute lung injury, treatment of Acute lung injury, and prevention of Acute lung injury. Exams and Tests Acute lung injury.
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of hemotherapy. We report a series of 90 TRALI reactions in 81 patients seconda
TY - JOUR. T1 - Human immunodeficiency virus infection and hospital mortality in acute lung injury patients. AU - Mendez-Tellez, Pedro A.. AU - Damluji, Abdulla. AU - Ammerman, Douglas. AU - Colantuoni, Elizabeth. AU - Fan, Eddy. AU - Sevransky, Jonathan E.. AU - Shanholtz, Carl. AU - Gallant, Joel E.. AU - Pronovost, Peter J.. AU - Needham, Dale M.. PY - 2010/7. Y1 - 2010/7. N2 - Objective: To evaluate the impact of human immunodeficiency virus infection on hospital mortality in patients with acute lung injury and to evaluate predictors of mortality among acute lung injury patients with human immunodeficiency virus. Design, setting, and patients: Retrospective study of human immunodeficiency virus-infected patients enrolled in an ongoing prospective cohort study of acute lung injury patients conducted at 13 intensive care units in four teaching hospitals in Baltimore, Maryland. Measurements and main results: Of 520 consecutive acute lung injury patients, 66 (13%) were human immunodeficiency ...
The report titled, Acute Lung Injury Treatment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017 - 2025 by TMR Research furnishes an in-depth analysis of the vital catalysts and deterrents of the global market for acute lung injury treatment, alongside accurate figures, charts, diagrams, and graphs. The report offers an insightful assessment of the leading geographical segments and the growth opportunities offered by each of them. Acute lung injury is a prominent cause of morbidity and mortality across the world. Since one of the common conditions that is associated with severe hypoxia is acute lung injury, acute lung injury treatment market is expected to soar as its incidence keeps escalating worldwide, augmenting mortality rates. Researchers can now have access to critical information pertaining to the pathophysiology of the condition as well as numerous biological markers related to worse clinical outcomes of patients, thanks to the recent technological ...
Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored intensively so far. In this study, we mainly analyzed the relationship between ferroptosis and LPS-induced ALI. In this study, a human bronchial epithelial cell line, BEAS-2B, was treated with LPS and ferrostatin-1 (Fer-1, ferroptosis inhibitor). The cell viability was measured using CCK-8. Additionally, the levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and iron, as well as the protein level of SLC7A11 and GPX4, were measured in different groups. To further confirm the in vitro results, an ALI model was induced by LPS in mice, and the therapeutic action of Fer-1 and ferroptosis level in lung tissues were evaluated. The cell viability of BEAS-2B was down-regulated by LPS treatment, together with the ferroptosis markers SLC7A11 and GPX4,
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecula …
Histone deacetylase (HDAC) inhibitors, developed as promising anti-tumor drugs, exhibit their anti-inflammatory properties due to their effects on reduction of inflammatory cytokines. To investigate the protective effect of butyrate, a HDAC inhibitor, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. ALI was induced in Balb/c mice by intratracheally instillation of LPS (1 mg/kg). Before 1 hour of LPS administration, the mice received butyrate (10 mg/kg) orally. The animals in each group were sacrificed at different time point after LPS administration. Pulmonary histological changes were evaluated by hematoxylin-eosin stain and lung wet/dry weight ratios were observed. Concentrations of interleukin (IL)-1β and tumor necrosis factor (TNF)-α in bronchoalveolar lavage fluid (BALF) and concentrations of nitric oxide (NO) and myeloperoxidase (MPO) activity in lung tissue homogenates were measured by enzyme-linked immunosorbent assay (ELISA). Expression of nuclear factor (NF)-κB p65 in
GlobalDatas clinical trial report, Acute Lung Injury Global Clinical Trials Review, H2, 2012 provides data on the Acute Lung Injury clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Acute Lung Injury. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Acute Lung Injury. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts. Note: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.
Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) and induce the production of regulatory dendritic cells (DCregs), but the potential link between these two cell types remains unclear. The goal of this study was to investigate the effect and mechanism of MSC-induced regulatory dendritic cells in ALI mice. In vivo experiments, C57BL/6 wild-type male mice were sacrificed at different times after intratracheal injection of LPS to observe changes in lung DC maturation and pathological damage. MSCs, DCregs or/and carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeled DCs were administered to the mice by tail vein, and flow cytometry was performed to measure the phenotype of lung DCs and T cells. Lung injury was estimated by the lung wet weight/body weight ratio and histopathological analysis. In vitro, Western blotting or flow cytometry was used to detect the expression of Notch ligand or receptor in MSCs or DCs after coculture or LPS stimulation. Finally, in vivo and
The pathogenesis of hyperlactatemia during sepsis is poorly understood. We have previously described an increase in lactate concentration across the lung in the dog during early endotoxemia. Accordingly, we sought to determine if the lung releases lactate in humans and what relation this has with lung injury. Methods: We measured lactate concentrations across the lung and lung injury scores (LIS) in two groups of patients. Group 1 consisted of nine patients with acute lung injury (LIS ≤2.0) and elevated lactate concentrations (,2.0 mmol/L). Group 2 contained 12 patients with no acute lung injury (LIS scores ≤1.5), with or without increased lactate concentrations. Simultaneous measurements of plasma lactate and blood gases were obtained from indwelling arterial and pulmonary artery, catheters. Measurements of cardiac output were also obtained. Lactate measurements were done using a lactate analyzer (YSI; Yellow Springs, Ohio). Results: For each patient with acute lung injury and ...
The acute lung injury progresses as lung damage mediated by many cellular (e.g., macrophages) and humoral (e.g., chemical mediators) immunological components, which constitute a complex network to amplify inflammatory responses, leading to acute lung injury. [14] In particular, activated neutrophils are thought to play an important role in formation of the network by releasing reactive oxygen species, proteases, and cytokines. [14] These potent mediators primarily attack the endothelial and epithelial cells. In this pathway, chemotaxins including IL-8 and thromboxane B2promote accumulation of neutrophils in the lung. [33,34] In the current study, intratracheal instillation of infant formula or breast milk increased infiltration of neutrophils into the alveolar spaces as well as decreasing the peripheral leukocyte counts. These changes were less prominent in the surfactant-treated rabbits. Our observations suggest that surfactant treatment mitigated recruitment of neutrophils to the lung. ...
Bone marrow mesenchymal stem cell (BMSCs)-based therapy seems to be a promising treatment for acute lung injury, but the therapeutic effects of BMSCs transplantation on acute lung injury induced by brain ischemia and the mechanisms have not been totally elucidated. This study explores the effects of transplantation of BMSCs on acute lung injury induced by focal cerebral ischemia and investigates the underlying mechanism. Acute lung injury model was induced by middle cerebral artery occlusion (MCAO). BMSCs (with concentration of 1 × 106/ml) were transplanted into host through tail vein 1 day after MCAO. Then, the survival, proliferation and migration of BMSCs in lung were observed at 4 days after transplantation, and histology observation and lung function were assessed for 7 days. Meanwhile, in situ hybridization (ISH), qRT-PCR and western blotting were employed to detect the expression of TNF-α in lung. Neurobehavioral deficits and acute lung injury could be seen in brain ischemia rats. Implanted
TY - JOUR. T1 - Growth arrest-specific protein 6 attenuates neutrophil migration and acute lung injury in sepsis. AU - Giangola, Matthew D.. AU - Yang, Weng Lang. AU - Rajayer, Salil R.. AU - Nicastro, Jeffrey. AU - Coppa, Gene F.. AU - Wang, Ping. PY - 2013/12. Y1 - 2013/12. N2 - Sepsis is an acute inflammatory condition that can result in multiple organ failure and acute lung injury. Growth arrest-specific protein 6 (Gas6) is a broad regulator of the innate immune response involved with the nuclear factor κB signaling pathway. We hypothesized that Gas6 could have a protective role in attenuating the severity of acute lung injury and sepsis. Male mice were subjected to sepsis by cecal ligation and puncture (CLP) after which recombinant murine Gas6 (rmGas6; 5 μg/mouse) or normal saline (vehicle) was administered intravenously. Blood and lung tissues were collected at 20 h after CLP for various measurements. Treatment with rmGas6 significantly reduced serum levels of the injury markers ...
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged with MHC class I mAb. In this study, when mice housed in a rodent, specific pathogen-free barrier room were challenged with MHC I mAb, there was significant protection from TRALI compared with nonbarrier mice. Priming mice with LPS restored lung injury with mAb challenge. Using TLR4-deficient bone marrow chimeras, the priming phenotype was restricted to animals with WT hematopoietic cells, and depletion of either neutrophils or platelets was protective. Both neutrophils and platelets were sequestered in the lungs of mice with TRALI, and retention of platelets was neutrophil dependent. Interestingly, treatment with aspirin prevented lung injury and mortality, but blocking the P selectin or CD11b/CD18 pathways did not. These data suggest a 2-step mechanism of TRALI: ...
TY - JOUR. T1 - Towards prevention of acute lung injury. T2 - Frequency and outcomes of emergency department patients at-risk - A multicenter cohort study. AU - Hou, Peter C.. AU - Elie-Turenne, Marie Carmelle. AU - Mitani, Aya. AU - Barry, Jonathan M.. AU - Kao, Erica Y.. AU - Cohen, Jason E.. AU - Frendl, Gyorgy. AU - Gajic, Ognjen. AU - Gentile, Nina T.. N1 - Funding Information: The STAR Center provided internal funding (Dr. Frendl), research staff, and biostatistical support, Brigham and Womens Hospital, Boston, MA. Dr. Gajic is supported in part by grants from the National Heart, Lung, and Blood Institute HL78743-01A1; National Center for Research Resources 1 KL2 RR024151. Dr. Gentile is supported in part by grants from the National Institute of Neurological Disorders and Stroke 5U10NS059039-04. The rest of the authors have no disclosures or conflict of interest.. PY - 2012/12. Y1 - 2012/12. N2 - Background: Few emergency department (ED) evaluations on acute lung injury (ALI) have been ...
Because experimental studies have shown that intact alveolar epithelial fluid transport function is critical for resolution of pulmonary edema and acute lung injury, we measured net alveolar fluid clearance in 79 patients with acute lung injury or the acute respiratory distress syndrome. Pulmonary e …
TY - JOUR. T1 - N-acetylcysteine abrogates acute lung injury induced by endotoxin. AU - Kao, Shang Jyh. AU - Wang, David. AU - Lin, Hen I.. AU - Chen, Hsing I.. PY - 2006/1. Y1 - 2006/1. N2 - 1. Acute lung injury (ALI) or acute respiratory distress syndrome is a serious clinical problem with high mortality. N-Acetylcysteine (NAC) is an anti-oxidant and a free radical scavenger. It has been reporeted recently that NAC ameliorates organ damage induced by endotoxin (lipopolysaccharide; LPS) in conscious rats. The present study was designed to evaluate the effects of NAC on LPS-induced ALI and other changes in anaesthetized rats. 2. Sprague-Dawley rats were anaesthetized with pentobarbital (40 mg/kg, i.p.). Endotracheal intubation was performed to provide artificial ventilation. Arterial pressure and heart rate were monitored. The extent of ALI was evaluated with the lung weight (LW)/bodyweight ratio, LW gain, exhaled nitric oxide (NO) and protein concentration in bronchoalveolar lavage (PCBAL). ...
Aim To investigate the role of inhibition of the PTEN in LPS-induced acute lung injury.Methods Tirty-two male SD rats were divided into LPS group and phen + LPS group(n = 16 each),then the mortality of rats in two groups was compared.Another sixty male SD rats were divided into four groups randomly:control group(n = 6),LPS group(n = 24),phen + LPS group(n = 24),phen group(n = 6).Both LPS group and phen + LPS group were subjected to 1,3,6 h and 12 h time point subgroups after LPS administration(n = 6 each).The concentrations of protein,tumor necrosis factor-α(TNF-α) andinterleukin-6(IL-6) inbronch-oalveolar lavage fluids(BALF) were detected.The histopathologic changes of lung tissues,and the expression of p-Akt in lung tissues were also observed.Results Phen pretreatment significantly decreased the LPS-induced lethality(P 0.05).In LPS group,the protein and cytokines in BALF were significantly increased(P 0.05) and the lung tissues showed obviously inflammatory responses under light microscopy
Previous randomized trials failed to demonstrate a decrease in mortality of patients with acute lung injury treated by exogenous surfactant. The aim of this prospective randomized study was to evaluate the effects of exogenous porcine-derived surfactant on pulmonary reaeration and lung tissue in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). Twenty patients with ALI/ARDS were studied (10 treated by surfactant and 10 controls) in whom a spiral thoracic computed tomography scan was acquired before (baseline), 39 hours and 7 days after the first surfactant administration. In the surfactant group, 3 doses of porcine-derived lung surfactant (200 mg/kg/dose) were instilled in both lungs at 0, 12 and 36 hours. Each instillation was followed by recruitment maneuvers. Gas and tissue volumes were measured separately in poorly/nonaerated and normally aerated lung areas before and seven days after the first surfactant administration. Surfactant-induced lung reaeration was
TY - JOUR. T1 - Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. AU - Festic, Emir. AU - Ortiz-Diaz, Enrique. AU - Lee, Augustine. AU - Li, Guangxi. AU - Kor, Daryl J.. AU - Adebola, Adesanya. AU - Akca, Ozan. AU - Hoth, Jason. AU - Levitt, Joseph E.. AU - Carter, Rickey. AU - Gajic, Ognjen. N1 - Funding Information: The work was supported in part by HL78743-01A1 , 1 KL2 RR024151 , and the Mayo Clinic Critical Care Research Committee . PY - 2013/12. Y1 - 2013/12. N2 - Purpose: Inhaled corticosteroids (ICSs) attenuated lung injury in animal studies. We investigated the association between prehospital ICS and incidence of acute lung injury (ALI) among patients at risk. Methods: In this ancillary analysis of the large multicenter Lung Injury Prediction Study cohort, we developed a propensity score for prehospital ICS use followed by matching, for all patients and for a subgroup of patients with at least 1 risk factor for direct pulmonary injury. The ...
https://doi.org/10.18632/oncotarget.20298 Kangfeng Jiang, Tao Zhang, Nannan Yin, Xiaofei Ma, Gan Zhao, Haichong Wu, Changwei Qiu, Ganzhen Deng
Linköping University, Department of Clinical and Experimental Medicine, Transfusion Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine. ...
The British Society for Haematology is registered in England and Wales as a Company Limited by Guarantee, No 2645706 and as a Charity, No 1005735 Registered Office and correspondence address: 100 White Lion Street London N1 9PF. Phone: 020 7713 0990 ...
Intravenous literature: Kleinman, S., Grossman, B. and Kopko, P. (2010). A national survey of transfusion-related acute lung injury risk reduction policies for platelets and plasma in the United States. Transfusion. [epub ahead of print] Abstract: BACKGROUND: Little information exists on the specific transfusion-related acute lung injury (TRALI) risk reduction practices used by multiple blood collecting…
Acute lung injury, a common condition characterized by acute severe hypoxia without evidence of hydrostatic pulmonary edema, remains a key source of mortality and morbidity in critically ill patients. The condition has a high incidence rate across the globe and overall rate of mortality remains high. Pathogenesis of the condition is explained by injuries to both the alveolar and endothelium epithelium. Recent advances in the field have helped researchers gain a better understanding of pathophysiology of the condition and several biological markers associated with worse clinical outcomes have been identified. Ongoing research in the area of fluid conservation and lung-protective ventilation strategies have demonstrated improvements in survival rate of patients. Potential treatment methods such as statin therapy and nutritional strategies are also expected to gain more focus from research bodies operating in the area of treatment of acute lung injury.. Request a sample copy of the Report @ ...
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are the leading causes of death in critical care. (LPS group) and the additional 18 rats received PFC through femoral vein prior to LPS instillation (LPS+PFC group). The rats in the control group were sacrificed 6 hours later on after saline instillation. At 2, 4 and 6 hours of exposure to LPS, 6 rats in the LPS group and 6 rats in LPS+PFC group were sacrificed at each time point. By analyzing pulmonary pathology, partial pressure of oxygen in the blood (PaO2) and lung wet-dry excess weight ratio (W/D) of each rat, we found that intravenous infusion of PFC significantly alleviated acute lung injury induced by LPS. Moreover, we BEZ235 novel inhibtior showed that the manifestation of pulmonary myeloperoxidase (MPO), intercellular adhesion molecule-1 (ICAM-1) of endothelial cells and CD11b of polymorphonuclear neutrophils (PMN) induced by LPS were significantly decreased by PFC treatment reported that ...
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Objective:Although ventilation with small tidal volumes is recommended in patients with established acute lung injury, most others receive highly variable tidal volume aimed in part at normalizing arterial blood gas values. We tested the hypothesis that acute lung injury, which develops after the in
The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There are currently no specific treatment strategies for avian influenza. We hypothesized that mesenchymal stromal cells (MSCs) would have beneficial effects in the treatment of H9N2 AIV-induced acute lung injury in mice. Six- to 8-week-old C57BL/6 mice were infected intranasally with 1 × 104 MID50 of A/HONG KONG/2108/2003 [H9N2 (HK)] H9N2 virus to induce acute lung injury. After 30 min, syngeneic MSCs were delivered through the caudal vein. Three days after infection, we measured the survival rate, lung weight, arterial blood gas, and cytokines in both bronchoalveolar lavage fluid (BALF) and serum, and assessed pathological changes to
The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There are currently no specific treatment strategies for avian influenza. We hypothesized that mesenchymal stromal cells (MSCs) would have beneficial effects in the treatment of H9N2 AIV-induced acute lung injury in mice. Six- to 8-week-old C57BL/6 mice were infected intranasally with 1 × 104 MID50 of A/HONG KONG/2108/2003 [H9N2 (HK)] H9N2 virus to induce acute lung injury. After 30 min, syngeneic MSCs were delivered through the caudal vein. Three days after infection, we measured the survival rate, lung weight, arterial blood gas, and cytokines in both bronchoalveolar lavage fluid (BALF) and serum, and assessed pathological changes to
TY - JOUR. T1 - Passive targeting of phosphatiosomes increases rolipram delivery to the lungs for treatment of acute lung injury. T2 - An animal study. AU - Fang, Chia Lang. AU - Wen, Chih Jen. AU - Aljuffali, Ibrahim A.. AU - Sung, Calvin T.. AU - Huang, Chun Lin. AU - Fang, Jia You. PY - 2015/7/10. Y1 - 2015/7/10. N2 - A novel nanovesicle carrier, phosphatiosomes, was developed to enhance the targeting efficiency of phosphodiesterase 4 (PDE4) inhibitor to the lungs for treating acute lung injury (ALI) by intravenous administration. Phosphatiosomes were the basis of a niosomal system containing phosphatidylcholine (PC) and distearoylphosphatidylethanolamine polyethylene glycol (DSPE-PEG). Rolipram was used as the model drug loaded in the phosphatiosomes. Bioimaging, biodistribution, activated neutrophil inhibition, and ALI treatment were performed to evaluate the feasibility of phosphatiosomes as the lung-targeting carriers. An encapsulation percentage of , 90% was achieved for rolipram-loaded ...
Stephen M. Black and a team of researchers have uncovered information that could help with treatment for acute lung injury. A summary of their study recently appeared in The Journal of Biological Chemistry, where they noted that a bacterial infection can throw off the equilibrium of two key proteins in the lungs and also put patients at risk of a highly lethal acute lung injury (ALI).. As Stephen M. Black explained in a recent press release, Bacteria can alter a single amino acid in the protein RhoA, pushing its activity level well above that of Rac1 and prompting blood vessels to leak and flood thousands of tiny air sacs in the lungs. Fortunately there might be a biological shield that is able to protect RhoA from potentially lethal alterations.. Stephen M. Black compared activation of RhoA to a rapid-fire gun that does not require the operator to pause and reload. As he explained, Activation of RhoA is an early, early event and it is a pathological activation. The cell cannot regulate it ...
TY - JOUR. T1 - Acute lung injury and nutritional support. AU - Gasperino, James. AU - Kvetan, Vladimir. PY - 2006/4/1. Y1 - 2006/4/1. KW - Acute lung injury. KW - Anti-oxidants. KW - Enteral feeding. KW - Fish oil. KW - Mechanical ventilation. UR - http://www.scopus.com/inward/record.url?scp=33645802011&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33645802011&partnerID=8YFLogxK. U2 - 10.1097/01.CCM.0000208328.77128.C1. DO - 10.1097/01.CCM.0000208328.77128.C1. M3 - Editorial. C2 - 16550085. AN - SCOPUS:33645802011. VL - 34. SP - 1265. EP - 1267. JO - Critical Care Medicine. JF - Critical Care Medicine. SN - 0090-3493. IS - 4. ER - ...
(Health-NewsWire.Net, March 24, 2020 ) Market Overview The Global Acute Lung Injury Market is expected to grow at a CAGR of 5.8% during the forecasting period (2019-2026). Acute lung injury is a severe condition caused by acute hypoxemic respiratory failure. It is a crucial source of mortality a
Press Release issued May 28, 2014: Reportstack, provider of premium market research reports announces the addition of Acute Lung Injury - Pipeline Review, H1 2014 market report to its offering Acute Lung Injury - Pipeline Review, H1 2014
Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell infiltration, activation and inflammatory cytokine release, enhancing basal alveolar fluid clearance and improving alveolar capillary barrier function.The Beta Agonist Lung Injury TrIal (prevention) is a multi-centre, randomised, double blind, placebo-controlled trial. The aim of the trial is to determine in patients undergoing elective transthoracic oesphagectomy, if treatment with inhaled salmeterol 100 mcg twice daily started at induction of anaesthesia and continued for 72 hours thereafter compared to placebo affect the incidence of early acute lung injury and other clinical, resource and patient focused outcomes. The primary outcome will be the development of acute lung injury within 72 hours of oesophagectomy. The trial secondary outcomes are the development of acute
TY - JOUR. T1 - Transfusion-related acute lung injury following random donor platelet transfusion. T2 - A report of two cases. AU - Ramanathan, Ramesh K.. AU - Triulzi, Darrell J.. AU - Logan, Theodore F.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Objectives: Transfusion-related acute lung injury (TRALI) following random donor platelet (RDP) transfusion is a rare complication of transfusion without any well-documented case reported in the English language literature. We describe 2 patients in whom TRALI occurred following RDP transfusion. Methods: Conventional clinical and laboratory methods. Results: Both patients developed acute shortness of breath 30-60 min after completion of RDP transfusion and required mechanical ventilatory support. Chest X-ray (CXR) in both cases revealed bilateral pulmonary infiltrates. Patient 1 required vasopressors for hypotension. Right heart catheterization ruled out fluid overload. Patient 2 remained hemodynamically stable. Both patients improved rapidly with continued ...
ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, which leads to low blood oxygen levels and respiratory failure. Common causes include pneumonia, septic shock, and lung trauma. Symptoms usually develop within 24 to 48 hours of the original injury or illness, and most patients require immediate care in an intensive care unit (ICU). The main form of treatment for ALI/ARDS is the delivery of oxygen and a continuous level of pressure to the damaged lungs through mechanical ventilation. Past research has shown that lower tidal volume ventilation (LTVV), a protective ventilator management technique in which lower volumes of oxygen are administered, improves short-term clinical outcomes in individuals with ALI/ARDS. However, the long-term impact of LTVV remains unknown. The purpose of this study is to evaluate the effects of LTVV on long-term outcomes in individuals with ALI/ARDS.. This study will enroll individuals admitted to an ...
ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, which leads to low blood oxygen levels and respiratory failure. Common causes include pneumonia, septic shock, and lung trauma. Symptoms usually develop within 24 to 48 hours of the original injury or illness, and most patients require immediate care in an intensive care unit (ICU). The main form of treatment for ALI/ARDS is the delivery of oxygen and a continuous level of pressure to the damaged lungs through mechanical ventilation. Past research has shown that lower tidal volume ventilation (LTVV), a protective ventilator management technique in which lower volumes of oxygen are administered, improves short-term clinical outcomes in individuals with ALI/ARDS. However, the long-term impact of LTVV remains unknown. The purpose of this study is to evaluate the effects of LTVV on long-term outcomes in individuals with ALI/ARDS.. This study will enroll individuals admitted to an ...
An attempt to validate the modification of the American-European consensus definition of acute lung injury/acute respiratory distress syndrome by the Berlin definition in a university hospital ...
Transfusion-related acute lung injury (TRALI) is defined as noncardiogenic pulmonary edema temporally related to the transfusion of blood products. We present a patient who, while undergoing orthotopic liver transplantation, developed acute pulmonary edema within minutes of administration of fresh frozen plasma (FFP).
References 1. Ashbaugh DG, Bigelow DB, Petty TL et al. Acute Respiratory Distress in Adults. Lancet. 1967; 2: 319-3232. Murray JF, Matthay MA, Luce JM et al. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988; 138: 720-7233. Bernard GR, Artigas A, Brigham KL et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes and clinical trial coordination. Am. J. Respir. Crit. Care Med. 1994 Mar; 149 (3 Pt 1): 818-8244. Rubenfeld GD, Herridge MS. Epidemiology and Outcomes of Acute Lung Injury. Chest. 2007; 131 (2): 554-5625. McCallum NS, Evans TW. Epidemiology of Acute Lung Injury. Current Opinion in Critical Care. 2005: 11; 43-496. Rubenfeld GD, Caldwell E, Peabody E et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353: 1685-16937. Finney SJ, Evans TW. Acute lung injury outside the ICU: a significant problem. Critical Care. 2007; 11: 1698. Hudson LD, Milberg JA, Anardi D et al. Clinical risks for ...
The main pathogenesis of acute lung injury induced by haemorrhagic shock is inflammation. BML-111, a lipoxinA(4)-receptor agonist, promotes acute inflammatory resolution. We sought to elucidate whether BML-111 protects haemorrhagic shock-induced acute lung injury in rats. Thirty two adult male rats were randomized to sham group (sham), haemorrhagic shock/resuscitation (HS), HS plus BML-111 (BML-111), and HS plus BML-111 and BOC-2 (BOC-2). Haemorrhagic shock was induced by blood drawing, and then resuscitation was obtained by infusion of shed blood and two-fold volume saline. Histological findings, as well as assays of neutrophilic infiltration (myeloperoxidase activity, ICAM-1 expression), inflammatory cytokines and pro-inflammatory factor (IκB-α and NF-κB p65) confirmed that haemorrhagic shock induced acute lung injury. BML-111 significantly mitigated acute lung injury induced by haemorrhagic shock. However, BOC-2, an antagonist of the lipoxinA(4)-receptor, partially reversed the protective ...
1. Gervais HW, Eberle B, Konietzke D, Hennes HJ, Dick W, Comparison of blood gases of ventilated patients during transport. Critical Care Medicine 1987;15:761-763.. 2. Weiss, Steven J., et al. Automatic Transport Ventilator Versus Bag Valve In The EMS Setting: A Prospective, Randomized Trial. Southern Medical Journal 98.10 (2005): 970-976.. 3. Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med. 2013 Nov 28;369(22):2126-36.. 4. Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, Protti A, Gotti M, Chiurazzi C, Carlesso E, Chiumello D, Quintel M. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med. 2016 Oct;42(10):1567-75.. 5. The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000, 342:1301-1308.. 6. Putensen C, Theuerkauf N, Zinserling J, Wrigge H, Pelosi P. ...
Pseudomonas aeruginosa is the most common gram-negative pathogen causing pneumonia in immunocompromised patients. Acute lung injury induced by bacterial exoproducts is associated with a poor outcome in P. aeruginosa pneumonia. The major pathogenic toxins among the exoproducts of P. aeruginosa and the mechanism by which they cause acute lung injury have been investigated: exoenzyme S and co-regulated toxins were found to contribute to acute lung injury. P. aeruginosa secretes these toxins through the recently defined type III secretion system (TTSS), by which gram-negative bacteria directly translocate toxins into the cytosol of target eukaryotic cells. TTSS comprises the secretion apparatus (termed the injectisome), translocators, secreted toxins, and regulatory components. In the P. aeruginosa genome, a pathogenic gene cluster, the exoenzyme S regulon, encodes genes underlying the regulation, secretion, and translocation of TTSS. Four type III secretory toxins, namely ExoS, ExoT, ExoU, and ...
This study by the Acute Respiratory Distress Syndrome Network supports the use of low tidal volumes in acute lung injury and ARDS, and is consistent with a previous trial.1 It differs from 3 previous negative trials2-4 by having a larger difference in tidal volumes between groups, and by having a more aggressive approach to correcting acidosis. This study provides important information about tidal volume size; however, further research is still needed to determine the importance of concurrent strategies such as positive end expiratory pressure (PEEP).. In this study, an equation based on sex and height was used to calculate a predicted body weight, which was then used to set tidal volumes. Obesity is a common problem; the use of measured body weight can inadvertently lead to the use of high tidal volume ventilation. Tidal volumes should be based on ideal versus measured body weight.. This information is relevant to nurses who care for mechanically ventilated patients. Through continuous ...
The aim of present study was to evaluate the protective effects of dexmedetomidine (DEX) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its possible mechanisms mediated by HMGB1. In vivo, pulmonary pathology observation and myeloperoxidase (MPO) activity were also examined to evaluate the protective effect of DEX in the lungs. Tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in bronchoalveolar lavage fluid (BALF), serum and lung tissues LPS-induced rats were detected. The oxidative indices including superoxide dismutase (SOD), Malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) in serum were also determined. Additionally, nitric oxide (NO), TNF-α, IL-6 and IL-1β, MDA, SOD and GSH-Px in the supernatants of LPS-induced BEAS-2B cells were measured. Furthermore, we detected the protein expression of high mobility group box-1 protein (HMGB1), Toll-like receptor 4 (TLR4), myeloid differentiating factor 88 (MyD88), inhibitor of ...
TY - CHAP. T1 - ROS signaling in the pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). AU - Kellner, Manuela. AU - Noonepalle, Satish. AU - Lu, Qing. AU - Srivastava, Anup. AU - Zemskov, Evgeny. AU - Black, Stephen M.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the excessive generation of oxygen radicals under pathological conditions such as acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) leads to increased endothelial permeability. Within this hallmark of ALI and ARDS, vascular microvessels lose their junctional integrity and show increased myosin contractions that promote the migration of polymorphonuclear leukocytes (PMNs) and the transition of solutes and fluids in the alveolar lumen. These processes all have a redox component, and this chapter focuses on the role played ...
Hintergrund: Beatmungsassoziierte Lungenschädigung (VILI; Ventilator-induced lung injury) trägt wesentlich zur Mortalität und Morbidität von Patienten mit Lungenversagen (ALI/ARDS, Acute Lung injury/Acute respiratory distress syndrome) bei. „Lungenprotektive Beatmung ist bis dato die einzige Intervention, die Mortalität bei ARDS nachweislich senkt. Jedoch kommt es auch unter lungenprotektiver Beatmung, insbesondere in vorgeschädigten Lungen wie bei Sepsis oder Pneumonie, zum Auftreten von VILI. 30-45 % aller Patienten mit ALI/ARDS entwickeln dieses auf dem Boden einer Pneumonie oder pneumogenen Sepsis. Zusätzlich zur protektiven Beatmung könnten neue adjuvante pharmakologische Therapiestrategien die beatmungsassoziierte Lungenschädigung weiter limitieren. In dieser Arbeit wurden Adrenomedullin und Simvastatin hinsichtlich eines protektiven Effektes gegenüber VILI untersucht. Adrenomedullin ist ein endogenes Peptid mit stabilisierenden Effekten auf die endotheliale Barrierefunktion, ...
TY - JOUR. T1 - Acute lung injury. T2 - A clinical and molecular review. AU - Butt, Yasmeen. AU - Kurdowska, Anna. AU - Allen, Timothy Craig. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2016/4. Y1 - 2016/4. N2 - Context.-Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are a continuum of lung changes arising from a wide variety of lung injuries, frequently resulting in significant morbidity and frequently in death. Research regarding the molecular pathophysiology of ALI/ ARDS is ongoing, with the aim toward developing prognostic molecular biomarkers and molecular-based therapy. Objective.-To review the clinical, radiologic, and pathologic features of ALI/ARDS; and the molecular pathophysiology of ALI/ARDS, with consideration of possible predictive/prognostic molecular biomarkers and possible molecular-based therapies. Data Sources.-Examination of the English-language medical literature regarding ALI and ARDS. Conclusions.-ARDS is primarily a ...
Although the etiology of TRALI has not been fully delineated, two hypotheses have been postulated. The antibody-mediated hypothesis proposes that antibodies react with a corresponding antigen triggering capillary leak. Identified antibodies include antibodies to human leukocyte antigen (HLA) class I and II antigens and human neutrophil antigen (HNA). In this hypothesis, antibodies bind to recipient neutrophils. The antibody bound neutrophils are then sequestered in the lungs where activation of complement results in endothelial damage, capillary leak, and ALI. In most of these cases, the antibody is found in the donor with the corresponding antigen identified on the recipients neutrophils. Most donors associated with cases of TRALI are multiparous women who become alloimmunized during pregnancy. One notable case supporting the antibody mediated hypothesis describes a patient who underwent lung transplantation and developed dyspnea and hypoxia after receiving a transfusion of two units of packed ...
TY - JOUR. T1 - Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. AU - Khan, Samina Yasmin. AU - Kelher, Marguerite R.. AU - Heal, Joanna M.. AU - Blumberg, Neil. AU - Boshkov, Lynn K.. AU - Phipps, Richard. AU - Gettings, Kelly F.. AU - McLaughlin, Nathan J.. AU - Silliman, Christopher C.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Transfusion-related acute lung injury (TRALI) is a form of posttransfusion acute pulmonary insufficiency that has been linked to the infusion of biologic response modifiers (BRMs), including antileukocyte antibodies and lipids. Soluble CD40 ligand (sCD40L) is a platelet-derived proinflammatory mediator that accumulates during platelet storage. We hypothesized that human polymorphonuclear leukocytes (PMNs) express CD40, CD40 ligation rapidly primes PMNs, and sCD40L induces ...
TY - JOUR. T1 - Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. AU - Arcaroli, John J.. AU - Hokanson, John E.. AU - Abraham, Edward. AU - Geraci, Mark. AU - Murphy, James R.. AU - Bowler, Russell P.. AU - Dinarello, Charles A.. AU - Silveira, Lori. AU - Sankoff, Jeff. AU - Heyland, Daren. AU - Wischmeyer, Paul. AU - Crapo, James D.. PY - 2009/1/15. Y1 - 2009/1/15. N2 - Rationale: Extracellular superoxide dismutase (EC-SOD) is a potent antioxidant that plays an important role in controlling oxidant-mediated stress and inflammation. High levels of EC-SOD are found in the lung. Acute lung injury (ALI) frequently occurs in patients with infection, and levels of EC-SOD have been shown to modulate severity of lung injury in transgenic animal models of endotoxemia-induced ALI. An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart ...
TY - JOUR. T1 - An alternative method of acute lung injury classification for use in observational studies. AU - Shah, Chirag V.. AU - Lanken, Paul N.. AU - Localio, A. Russell. AU - Gallop, Robert. AU - Bellamy, Scarlett. AU - Ma, Shwu Fan. AU - Flores, Carlos. AU - Kahn, Jeremy M.. AU - Finkel, Barbara. AU - Fuchs, Barry D.. AU - Garcia, Joe G.N.. AU - Christie, Jason D.. N1 - Funding Information: Funding/Support: This work was supported by the National Institutes of Health [Grants P50HL60290, HL079063, T32 HL07891 ] and EMER07/001 . PY - 2010/11/1. Y1 - 2010/11/1. N2 - Background: In observational studies using acute lung injury (ALI) as an outcome, a spectrum of lung injury and difficult-to-interpret chest radiographs (CXRs) may hamper efforts to uncover risk factor associations. We assessed the impact of excluding patients with difficult-to-classify or equivocal ALI diagnosis on clinical and genetic risk factor associations for ALI after trauma. Methods: This study was of a prospective ...
This study was accepted to be presented for an award at the 25th Argentine Congress of Intensive Therapy. In December, 2015, this study received the 2015 Award for Best Scientific Study from the Sanatorio Anchorena Teaching and Research Committee. Conflict of interest: The authors declare that there is no conflict of interest associated with this publication. Bibliography 1. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308. 2. Protti A, Cressoni M, Santini A, et al. Lung stress and strain during mechanical ventilation: any safe threshold? Am J Respir Crit Care Med 2011; 183: 1354-1362. 3. Brochard L, Rauss A, Benito S, et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 1994; 150: 896-903. 4. Esteban A, Frutos F, ...
Biphasic positive airway pressure (BIVENT) is a partial support mode that employs pressure-controlled, time-cycled ventilation set at two levels of continuous positive airway pressure with unrestricted spontaneous breathing. BIVENT can modulate inspiratory effort by modifying the frequency of controlled breaths. Nevertheless, the optimal amount of inspiratory effort to improve respiratory function while minimizing ventilator-associated lung injury during partial ventilatory assistance has not been determined. Furthermore, it is unclear whether the effects of partial ventilatory support depend on acute lung injury (ALI) etiology. This study aimed to investigate the impact of spontaneous and time-cycled control breaths during BIVENT on the lung and diaphragm in experimental pulmonary (p) and extrapulmonary (exp) ALI. This was a prospective, randomized, controlled experimental study of 60 adult male Wistar rats. Mild ALI was induced by Escherichia coli lipopolysaccharide either intratracheally (ALIp) or
TY - JOUR. T1 - Functional genomic assessment of phosgene-induced acute lung injury in mice. AU - Leikauf, George D.. AU - Concel, Vincent J.. AU - Bein, Kiflai. AU - Liu, Pengyuan. AU - Berndt, Annerose. AU - Martin, Timothy M.. AU - Ganguly, Koustav. AU - Jang, An Soo. AU - Brant, Kelly A.. AU - Dopico, Richard A.. AU - Upadhyay, Swapna. AU - Cario, Clinton. AU - Peter Di, Y. P.. AU - Vuga, Louis J.. AU - Kostem, Emrah. AU - Eskin, Eleazar. AU - You, Ming. AU - Kaminski, Naftali. AU - Prows, Daniel R.. AU - Knoell, Daren L.. AU - Fabisiak, James P.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - In this study, a genetically diverse panel of 43 mouse strains was exposed to phosgene and genome-wide association mapping performed using a high-density single nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was also used to improve the genetic resolution in the identification of genetic determinants of phosgene-induced acute lung injury (ALI). We prioritized the identified genes based on whether ...
Dive into the research topics of ROS signaling in the pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). Together they form a unique fingerprint. ...
Authors: Wang, Bing , Wu, Bin , Ran, Yan-Ni Article Type: Research Article Abstract: OBJECTIVE: This study aims to explore whether positive end-expiratory pressure (PEEP) guided by esophageal pressure is better than the acute respiratory distress syndrome network (ARDSNet) during the treatment of traumatic acute respiratory distress syndrome (ARDS) patients. SUGGESTIONS: The use of the oxygenation method of inhaled oxygen concentration titration PEEP is suggested. METHODS: This study takes traumatic ARDS patients as the research object. The data of 23 patients were included in this study. The patients were randomly divided into two groups: the esophageal pressure titration PEEP group (n = …12), and the ARDSNet (PEEP-FiO 2 table) titration PEEP group (n = 11). All patients were given mechanical ventilation, and changes in oxygenation index, respiratory mechanics, hemodynamics and inflammatory reaction index were recorded when titrating the best PEEP with the two methods on the current day of ...
ARDSNET STUDY PDF - Low tidal volume, low pressure. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal.
ARDSNET STUDY PDF - Low tidal volume, low pressure. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal.
Treatment of acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), remain unsolved problems of intensive care medicine. ALI/ARDS are characterized by lung edema due to increased permeability of the alveolar-capillary barrier and subsequent impairment of arterial oxygenation. Lung edema, endothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and broncheoalveolar space. Hence, activation and recruitment of neutrophils are regarded to play a key role in progression of ALI/ARDS. Neutrophils are the first cells to be recruited to the site of inflammation and have a potent antimicrobial armour that includes oxidants, proteinases and cationic peptides. Under pathological circumstances, however, unregulated release of these microbicidal compounds into the extracellular space paradoxically can damage host tissues. This review focuses on the mechanisms of neutrophil recruitment into the lung and on the contribution of neutrophils
The overall aim of the present thesis was to study aspects of patient safety in critically ill patients with special focus on airway management, respiratory complications and nursing procedures. Study I describes a method called pharyngeal oxygen administration during intubation in an experimental acute lung injury model. The study showed that pharyngeal oxygenation prevented or considerably increased the time to life-threatening hypoxemia at shunt fractions by at least up to 25% and that this technique could be implemented in airway algorithms for the intubation of hypoxemic patients. In study II, we investigated short-term disconnection of the expiratory circuit from the ventilator during filter exchange in critically ill patients. We demonstrated that when using pressure modes in the ventilator, there was no indication of any significant deterioration in the patients lung function. A bench test suggests that this result is explained by auto-triggering with high inspiratory flows during the ...
Today we will be discussing TRALI, or transfusion-related acute lung injury. TRALI accounts for almost half of all transfusion-related fatalities in the United States.. Although several mechanisms exist, one of the major causes of TRALI is donor antibodies to white blood cells, such as human leukocyte antigen and human neutrophil antigen, or commonly referred to as HLA and HNA.. Dr. AuBuchon who wrote an editorial in TRANSFUSION comments:. Blood collectors in the United States have taken steps over the last half-dozen years to reduce the risk of TRALI through plasma, and, in many cases, also apheresis platelets. This has primarily involved women who have previously been pregnant, either deferring the use of their plasma or testing them to identify those lacking HLA antibodies. These steps have resulted in a reduction of TRALI risk by about three-quarters.. Dr. Vandekerckhove and his colleagues in Belgium screened 77 male plateletpheresis donors with a history of transfusions and 942 female ...
Background: Acute lung injury is an important cause of respiratory failure in the critically ill patient. It is caused by damage to the alveolar barrier with subsequent alveolar flooding leading to the development of refractory hypoxaemia. beta Agonists stimulate alveolar fluid clearance in animal models of lung injury. In a clinical trial (BALTI-1), intravenous beta agonists reduced extravascular lung water, an effect that took 72 h in contrast with what animal studies suggest. One possible explanation for the delay in change in extravascular lung water is the time required for salbutamol to stimulate alveolar epithelial repair ...
Research outputs, collaborations and relationships for Acute Lung Injury (ALI) / Adult Respiratory Distress Syndrome (ARDS) Center of Excellence, Pitt published between 1 June 2019 - 31 May 2020 as tracked by the Nature Index.
TY - JOUR. T1 - Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. AU - Jacobson, Jeffrey R.. AU - Barnard, Joseph W.. AU - Grigoryev, Dmitry N.. AU - Ma, Shwu Fan. AU - Tuder, Rubin M.. AU - Garcia, Joe G N. PY - 2005/6. Y1 - 2005/6. N2 - Therapies to limit the life-threatening vascular leak observed in patients with acute lung injury (ALI) are currently lacking. We explored the effect of simvastatin, a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor that mediates endothelial cell barrier protection in vitro, in a murine inflammatory model of ALL C57BL/6J mice were treated with simvastatin (5 or 20 mg/kg body wt via intraperitoneal injection) 24 h before and again concomitantly with intratracheally administered LPS (2 μg/g body wt). Inflammatory indexes [bronchoalveolar lavage (BAL) myeloperoxidase activity and total neutrophil counts assessed at 24 h with histological confirmation] were markedly increased after LPS alone but significantly ...
Acute lung injury (ALI) is a prevalent and devastating condition in the intensive care unit. Although pulmonary artery catheters (PAC) provide clinicians with important data about a patients haemodynamic status, doubts about their clinical benefit and worries about safety have raised questions about their usefulness. This study was designed to address this issue, with 1000 patients recruited in 20 North American centres. Patients were recruited after being diagnosed with ALI and were managed haemodynamically according to a standardised management protocol. 513 patients were randomised to have a PAC and 487 to have a standard central venous catheter (CVC).. Both the PAC and CVC groups had similar rates of death during the first 60 days (27.4% and 26.3% respectively, p = 0.69). Mean (SE) ventilator-free days were also similar (13.2 (0.5) and 13.5 (0.5), p = 0.58), as were the number of days not spent in the intensive care unit up to day 28 (12.0 (0.4) and 12.5 (0.5), p = 0.40). Using a PAC did ...
Acute respiratory distress syndrome (ARDS) is a life threatening respiratory failure due to lung injury from a variety of precipitants. Pathologically ARDS is characterised by diffuse alveolar damage, alveolar capillary leakage, and protein rich pulmonary oedema leading to the clinical manifestation of poor lung compliance, severe hypoxaemia, and bilateral infiltrates on chest radiograph. Several aetiological factors associated with the development of ARDS are identified with sepsis, pneumonia, and trauma with multiple transfusions accounting for most cases. Despite the absence of a robust diagnostic definition, extensive epidemiological investigations suggest ARDS remains a significant health burden with substantial morbidity and mortality. Improvements in outcome following ARDS over the past decade are in part due to improved strategies of mechanical ventilation and advanced support of other failing organs. Optimal treatment involves judicious fluid management, protective lung ventilation with ...
The Acute Lung Injury (ALI) Center of Excellence, under the direction of Rama Mallampalli, MD, is focused on the investigation of fundamental mechanisms underlying the development and repair of lung injury, and the translational and clinical implications. The program utilizes state-of-the-art tools in molecular, biochemical, translational, and clinical investigation. Investigators within the Center are supported by the National Institutes of Health through 12 R01 grants and a Program Project Grant, by the Department of Veterans Affairs with two VA Merit awards, and by several philanthropic societies through seven investigator-initiated grant awards. Collaborative interactions exist with investigators in the Departments of Anesthesiology, Critical Care Medicine, Environmental and Occupational Health, Pathology, and Surgery. In addition to cutting-edge basic and translational science, investigators in the Center are currently establishing and participating in clinical trials with mesenchymal stem ...
Severe trauma, caused by flame burn and smoke (B + S) inhalation induces acute lung injury (ALI) and results in the loss of pulmonary function. A cascade of molecular and cellular events initiates the formation of reactive oxygen/nitrogen species (ROS/RNS) that in turn drives an inflammatory response and consequently cell death through hyper-activation of poly (ADP-ribose) polymerase (PARP-1). The purpose of this study was to investigate and counteract pulmonary dysfunction associated with nitrosative stress generated after B + S inhalation injury in an ovine and murine model of ALI. \r\nIn our time course experiment, sheep were sacrificed at 4, 8, 12, 18 and 24 hours post B + S injury. From 4 through 24 hours, there was a progressive increase in airway obstruction and lung edema formation. Furthermore, injury was associated with increased ROS/RNS generation, pro-inflammatory cytokine expression and neutrophil accumulation. Additionally, PARP-1 enzymatic activity increased in parallel with ...
Kallet RH, Matthay MA (January 2013). "Hyperoxic acute lung injury". Respiratory Care. 58 (1): 123-41. doi:10.4187/respcare. ... "Reactive oxygen species contribute to oxygen-related lung injury after acid aspiration". Anesthesia and Analgesia. 87 (1): 127- ... In context of acute hypoxemia, oxygen therapy should be titrated to a target level based on pulse oximetry (94-96% in most ... Within the lungs, hypoxia is observed to be a potent pulmonary vasoconstrictor, due to inhibition of an outward potassium ...
Transfusion-related acute lung injury (TRALI) is a syndrome that is similar to acute respiratory distress syndrome (ARDS), ... Kim, Jeongmin; Na, Sungwon (30 March 2015). "Transfusion-related acute lung injury; clinical perspectives". Korean Journal of ... Acute hemolytic reactions are defined according to Serious Hazards of Transfusion (SHOT) as "fever and other symptoms/signs of ... Kidney injury may occur because of the effects of the hemolytic reaction (pigment nephropathy). The severity of the transfusion ...
Christiani, David C. (2020-03-05). "Vaping-Induced Acute Lung Injury". New England Journal of Medicine. 382 (10): 960-962. doi: ... Recently[when?], the life-threatening 'vaping associated lung injury' syndrome was described, it is a form of Lipoid pneumonia ... Isaac Adler was the first to strongly suggest that lung cancer is related to smoking. Prior to World War I, lung cancer was a ... Lickint also argued that tobacco use was the best way to explain the fact that lung cancer struck men four or five times more ...
One of the primary complications that presents in patients mechanically ventilated is acute lung injury (ALI)/acute respiratory ... Common specific medical indications for mechanical ventilation include: Surgical procedures Acute lung injury, including acute ... "Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory ... Hoesch RE, Lin E, Young M, Gottesman RF, Altaweel L, Nyquist PA, Stevens RD (February 2012). "Acute lung injury in critical ...
... transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a ... "Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside". Blood Reviews. 29 (1): 51- ... "Antibody-mediated transfusion-related acute lung injury; from discovery to prevention". British Journal of Haematology. 170 (5 ... infections through better skin cleansing procedures and the incidence of life-threatening transfusion-related acute lung injury ...
These gaseous products can cause acute lung injury. Chronic exposure, for example, from the air at swimming pools where ...
VII Acute Lung Injury with Siderophages Guido Majno; Isabelle Joris (12 August 2004). Cells, Tissues, and Disease : Principles ... The lungs are especially sensitive and prone to damage, thus to avoid collateral damage to type 1 and type II pneumocytes, ... Such black granules may be especially common in smoker's lungs or long-term city dwellers. The alveolar macrophage is the third ... TGF-β is activated by diverse mechanisms in the lung, ultimately involving either proteolysis or conformational alteration of ...
Kawabata K, Hagio T, Matsuoka S (September 2002). "The role of neutrophil elastase in acute lung injury". European Journal of ... of neutrophil elastase can lead to disruption of pulmonary barrier showing symptoms corresponding with acute lung injury. The ... Neutrophils are recruited to the site of injury within minutes following trauma and are the hallmark of acute inflammation; ... During the beginning (acute) phase of inflammation, particularly as a result of bacterial infection, environmental exposure, ...
A 2006 issue of Awake! highlighted dangers from transfusion-related acute lung injury (TRALI). Opposition to the Watch Tower ... Cardiopulmonary bypass, a method in which blood is diverted to an artificial heart-lung machine and directed back into the ...
2005). "Transfusion-related acute lung injury: definition and review". Crit Care Med. 33 (4): 721-6. doi:10.1097/01.ccm. ... 2009). "FIO2 and acute respiratory distress syndrome definition during lung protective ventilation". Crit Care Med. 37 (1): 202 ... and FIO2 is used as an indicator of hypoxemia per the American-European Consensus Conference on lung injury. A high FIO2 has ... This helps to determine the degree of any problems with how the lungs transfer oxygen to the blood. A sample of arterial blood ...
... especially in the context of ARDS and acute lung injury. This is commonly referred to as lung protective ventilation. There are ... Krishnan JA, Brower RG (2000). "High-frequency ventilation for acute lung injury and ARDS". Chest. 118 (3): 795-807. doi: ... Jet ventilation has been shown to reduce ventilator induced lung injury by as much as 20%. Usage of high-frequency jet ... High frequency ventilation is thought to reduce ventilator-associated lung injury (VALI), ...
Kawabata K, Hagio T, Matsuoka S (September 2002). "The role of neutrophil elastase in acute lung injury". European Journal of ... Moraes TJ, Chow CW, Downey GP (April 2003). "Proteases and lung injury". Critical Care Medicine. 31 (4 Suppl): S189-94. doi: ... acute respiratory distress syndrome, and cystic fibrosis. A recent study shows that patients with CTSG gene polymorphisms have ... ischemic reperfusion injury, and bone metastasis. It is also implicated in a variety of infectious inflammatory diseases, ...
Brochard LJ (November 2009). "Tidal volume during acute lung injury: let the patient choose?". Intensive Care Medicine. 35 (11 ... As a result, the pressure in the airway drops, causing an inflow of air into the lungs. With NAVA, the electrical activity of ... Del Sorbo L, Slutsky AS (February 2010). "Ventilatory support for acute respiratory failure: new and ongoing pathophysiological ... March 2010). "Neurally adjusted ventilatory assist increases respiratory variability and complexity in acute respiratory ...
In a mouse model for acute lung injury (ALI), ELOM-080 reduced LPS-induced lung injury, among other actions by inhibiting the ... December 2016). "Standardized myrtol attenuates lipopolysaccharide induced acute lung injury in mice". Pharmaceutical Biology. ... These species are considered to be the most frequent bacterial pathogens of acute bronchitis and are also suspected in acute ... ELOM-080 and an essential oil were administered to a total of 331 adults with acute nasal sinus inflammations (acute sinusitis ...
It includes acute lung injury and acute respiratory distress syndrome. (ALI-ARDS) cover many of these causes, but they may also ... Transfusion associated Acute Lung Injury is a specific type of blood-product transfusion injury that occurs when the donors ... embolism Acute lung injury may also cause pulmonary edema directly through injury to the vasculature and parenchyma of the lung ... This is the classical form of acute lung injury-adult respiratory distress syndrome. Some causes of pulmonary edema are less ...
Death TACO and transfusion-related acute lung injury (TRALI) are both complications following a transfusion, and both can ... Skeate, Robert C; Eastlund, Ted (November 2007). "Distinguishing between transfusion related acute lung injury and transfusion ... "Transfusion-related acute lung injury and transfusion-associated circulatory overload". ISBT Science Series. 1 (1): 107-111. ... It is often confused with transfusion-related acute lung injury (TRALI), another transfusion reaction. The difference between ...
"Long pentraxin 3 in pulmonary infection and acute lung injury". American Journal of Physiology. Lung Cellular and Molecular ... PTX3 behaves as an acute phase response protein, as the blood levels of PTX3, low in normal conditions (about 25 ng/mL in the ... Lee GW, Goodman AR, Lee TH, Vilcek J (October 1994). "Relationship of TSG-14 protein to the pentraxin family of major acute ... is a novel member of the pentaxin family of acute phase proteins". Journal of Immunology. 150 (5): 1804-12. PMID 7679696. Alles ...
2021). "A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice". eLife. 16 ... "Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury". PLOS Pathogens. 13 (6): ... Absence of the enzyme renders mice more likely to develop severe lung injury and die if they are challenged with intratracheal ... 2018). "LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma". J Exp Med. 215 (9): ...
"Salidroside attenuates acute lung injury via inhibition of inflammatory cytokine production". Biomedicine & Pharmacotherapy. ...
"Management of acute lung injury: sharing data between adults and children". Respiratory Care. 56 (9): 1258-68, discussion 1268- ... They practice in acute care facilities, long-term acute care facilities, skilled nursing facilities, assisted-living centers, ... Scientific research also takes place to look for causes and possible treatment in diseases such as asthma and lung cancer. The ... Respiratory therapists educate, assist in diagnosis, and treat people who have heart and lung problems. Specialized in both ...
"Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury". The Journal of Clinical ... This effect is seen not only with neutrophils in the blood, but also in various tissues such as the gut, lung, liver, and blood ... specifically in the lung capillaries and liver sinusoids). Intra-vascular NET formation is tightly controlled and is regulated ... "Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke". Stroke. 49 (3): 754- ...
His initial research focused on animal models of acute lung injury. Montaner initially planned on returning to Argentina after ... Montaner, J.G.; Russel, J.; Lawson, L.; Ruedy, J. (1989). "Acute Respiratory Failure Secondary to Pneumocystis Carinii ...
In the case of non-allergic acute lung injury, standard or recommended approaches to treatment have not been defined. The ... "Chemical Pneumonitis and Acute Lung Injury Caused by Inhalation of Nickel Fumes". Internal Medicine. 50 (18): 2035-8. doi: ... Patients may present with wheezing or crackles in the lungs. They typically have an increased white blood cell count, and urine ... When respiratory symptoms are prominent, metal fume fever may be confused with acute bronchitis or pneumonia. The diagnosis is ...
"Female Plasma May Not Increase Risk for Transfusion-Related Acute Lung Injury". Medscape. October 23, 2007. Archived from the ... because of concerns about transfusion related acute lung injury (TRALI) and female donors who may have higher leukocyte ...
Manicone, Anne M (2009-01-01). "Role of the pulmonary epithelium and inflammatory signals in acute lung injury". Expert Review ... "Acute Respiratory Distress Syndrome (ARDS) , American Lung Association , American Lung Association". www.lung.org. Retrieved ... such as acute interstitial pneumonia) and that ARDS can occur without DAD. Diffuse alveolar damage (DAD): an acute lung ... The most important factor for treating DAD or ARDS is to treat the underlying cause of the injury to the lungs, for example ...
2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. ...
Of people who have survived drowning, almost one-third will experience complications such as acute lung injury (ALI) or acute ... Jin, Faguang; Li, Congcong (5 April 2017). "Seawater-drowning-induced acute lung injury: From molecular mechanisms to potential ... These lung injuries can be contributed by water aspiration and also irritants present in the water such as microbial pathogens ... Some literature suggests that occurrences of drowning can lead to acute kidney injury from lack of blood flow and oxygenation ...
2006). "The role of metallothionein in the pathogenesis of acute lung injury". Am. J. Respir. Cell Mol. Biol. 34 (1): 73-82. ...
Amirshahrokhi K, Bohlooli S (October 2013). "Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in ... "Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats". Archives of ... Schoenig G (1968). Acute oral toxicity of sample No. 751, dimethyl sulfone 1 BT No. A6409. Northbrook, Illinois: Industrial BIO ... The study also evaluated an acute 12g dose and found significant improvements in all symptoms except itching eyes and sneezing ...
... airway pressure release ventilation is indicated in patients with acute lung injury, acute respiratory distress syndrome and ... 1991). "Airway pressure release ventilation during acute lung injury: a prospective multicenter trial". Critical Care Medicine ... 2003). "Spontaneous breathing improves lung aeration in oleic acid-induced lung injury". Anesthesiology. 99 (2): 376-84. doi: ... "Long-term effects of two different ventilatory modes on oxygenation in acute lung injury. Comparison of airway pressure release ...
Pediatric acute appendicitis[edit]. interleukin-6 has been shown to be elevated in paediatric patients with acute appendicitis ... July 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage". Progress in ... plays a role in causing poor lung function and increased risk for developing asthma exacerbations.[97] ... IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow ...
Tahricht, sheep offal (brains, tripe, lungs, and heart) rolled up with the intestines on an oak stick and cooked on embers in ... However, "a massacre ensued in which the Berbers took revenge for many personal and collective injuries and permanently settled ... "immediately detrimental consequence of this acute consciousness of ancestry was the revival of ethnic disparagement, directed ...
The excessive interstitial lung fluid traverses the visceral pleura and accumulates in the pleural space.[citation needed] ... Briefly, transudate is produced through pressure filtration without capillary injury while exudate is "inflammatory fluid" ... Lung ultrasound, nearly as accurate as CT and more accurate than chest X-ray, is increasingly being used at the point of care ... A pleural effusion is accumulation of excessive fluid in the pleural space, the potential space that surrounds each lung. Under ...
Recombinant human ACE2 (rhACE2) is surmised to be a novel therapy for acute lung injury, and appeared to improve pulmonary ... "The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice". Experimental Physiology. 93 (5): ... On the other hand, sACE2 has been shown to have a protective effect against virus-induced lung injury by increasing the ... in SARS coronavirus-induced lung injury". Nature Medicine. 11 (8): 875-879. doi:10.1038/nm1267. PMC 7095783. PMID 16007097.. ...
The fight-or-flight or the fight-flight-or-freeze response (also called hyperarousal or the acute stress response) is a ... The blood clotting function of the body speeds up in order to prevent excessive blood loss in the event of an injury sustained ... Acceleration of heart and lung action. *Paling or flushing, or alternating between both ... has led researchers to use more neutral or accommodating terminology such as hyperarousal or the acute stress response. ...
Jessen KR, Mirsky R «The Success and Failure of the Schwann Cell Response to Nerve Injury» (en anglès). Front Cell Neurosci, ... Dubois, SG; London, WB; Zhang, Y; Matthay, KK; et al «Lung metastases in neuroblastoma at initial diagnosis: A report from the ... Oliveira AS, Calia LC, Kiyomoto BH, Póvoa EF, et al «Acute necrotizing myopathy and podophyllin toxicity. Report of a fatal ... Mendonca DA, Staiano JJ, Drew PJ «An unusual cutaneous neuroma following a burn injury» (en anglès). J Plast Reconstr Aesthet ...
Lung and. lower respiratory tract injuries. *Pneumothorax. *Hemothorax. *Hemopneumothorax. *Pulmonary contusion. *Pulmonary ... for ex situ investigation of heart rhythm responses to acute mechanical stimulation". Progress in Biophysics and Molecular ... Chest protectors and vests are designed to reduce trauma from blunt bodily injury, but this does not offer protection from ... Being less developed, the thorax of an adolescent is likely more prone to this injury given the circumstances. ...
"Sex differences in symptom presentation in acute myocardial infarction: A systematic review and meta-analysis". Heart & Lung ... This would explain the association between fainting and stimuli such as bloodletting and injuries seen in blood-injection- ... If there is underlying fear or anxiety (e.g., social circumstances), or acute fear (e.g., acute threat, needle phobia), the ... Recommended acute treatment of vasovagal and orthostatic (hypotension) syncope involves returning blood to the brain by ...
2006). "NXY-059 for acute ischemic stroke". N Engl J Med. 354 (6): 588-600. doi:10.1056/NEJMoa052980. PMID 16467546.. ... 1996). "Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial". J ... Wilson J; Gelb A (2002). "Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by ... Caraballoso M; Sacristan M; Serra C; Bonfill X (2003). "Drugs for preventing lung cancer in healthy people". Cochrane Database ...
Tubercle and Lung Disease. 1994, roč. 75, čís. 2, s. 138-43. DOI 10.1016/0962-8479(94)90043-4. PMID 8032047.. ... WHO Disease and injury country estimates [online]. Světová zdravotnická organizace, 2004 [cit. 2009-11-11]. Dostupné online.. ... Kim, J., Park, Y., Kim, Y., Kang, S., Shin, J., Park, I., Choi, B. Miliary tuberculosis and acute respiratory distress syndrome ... The International Journal of Tuberculosis and Lung Disease. 2003, roč. 7, čís. 4, s. 359-64. PMID 12733492.. ...
Okamoto M, Kita T, Okuda H, Tanaka T, Nakashima T (July 1994). "Effects of aging on acute toxicity of nicotine in rats". ... Rogers AJ, Denk LD, Wax PM (February 2004). "Catastrophic brain injury after nicotine insecticide ingestion". The Journal of ... 2019-20 vaping lung illness outbreak. *Hospitalized cases in the vaping lung illness outbreak ... Malizia E, Andreucci G, Alfani F, Smeriglio M, Nicholai P (April 1983). "Acute intoxication with nicotine alkaloids and ...
... allowing lung gases to get into the pulmonary return circulation, the pleura, or the interstitial areas near the injury, where ... by these early rebreather systems limited the depth at which they could be used due to the risk of convulsions caused by acute ... The word Aqua-Lung, which first appeared in the Cousteau-Gagnan patent, is a trademark, currently owned by Aqua Lung/La ... "Aqua-Lung Trademark of Aqua Lung America, Inc. - Registration Number 2160570 - Serial Number 75294647 :: Justia Trademarks". ...
Most fetal birth injuries resolve without long term harm, but brachial plexus injury may lead to Erb's palsy or Klumpke's ... Hypoxic damage can also occur to most of the infant's organs (heart, lungs, liver, gut, kidneys), but brain damage is of most ... The postpartum period can be divided into three distinct stages; the initial or acute phase, six to 12 hours after childbirth; ... 20 or 30 encounter injuries, infections or disabilities. Most of these deaths and injuries are preventable. In 2008, noting ...
The virus can cause acute myocardial injury and chronic damage to the cardiovascular system. An acute cardiac injury was found ... The main pathological findings at autopsy are: Macroscopy: pericarditis, lung consolidation and pulmonary oedema Lung findings ... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel severe acute respiratory syndrome coronavirus. It was ... but acute myocardial injuries may also be related to ACE2 receptors in the heart. ACE2 receptors are highly expressed in the ...
"Aqua Lung 1947-2007, soixante ans au service de la plongée sous-marine!" (in French). Campbell, Bob (Summer 2006). "Siebe- ... and to greater risks of serious injury or death. These risks may be reduced by appropriate skills, knowledge and experience, ... by these early rebreather systems limited the depth at which they could be used due to the risk of convulsions caused by acute ... During WWII Jacques Cousteau and Frédéric Dumas used the Aqua-Lung for underwater archaeology to excavate a large mound of ...
... is characterized by elevated blood calcium levels, metabolic alkalosis, and acute kidney injury. Milk- ... and lungs. If ingestion of calcium and alkali is continued, neurologic symptoms such as memory loss, personality changes, ... and acute kidney injury. In general, milk-alkali syndrome starts with excess calcium levels in the body (hypercalcemia), which ... "Hypercalcemia-Induced ST-Segment Elevation Mimicking Acute Myocardial Injury: A Case Report and Review of the Literature". Case ...
Complications may include lung abscess, acute respiratory distress syndrome, empyema, and parapneumonic effusion. Some include ... dysphagia when compared to stroke patients because patients with stroke will improve as they recover from their acute injury, ... The two lung changes after acid aspiration are: a) direct toxic damage to the respiratory epithelium resulting in interstitial ... Aspiration pneumonia is a type of lung infection that is due to a relatively large amount of material from the stomach or mouth ...
Retrieved 14 October 2021.. " "Scorpion envenomation causing skin necrosis, hemolysis, DIC, and acute kidney injury (Middle ... His research includes ketone levels in the lungs and blood, and pesticide exposures and scorpion stings in young children. He ... In 1997, The dogma of avoiding analgesics in patients with acute abdominal pain was challenged, and in one of the first studies ... LoVecchio's research mainly focuses on ketone levels in the lungs and blood, and pesticide exposures and scorpion stings in ...
... and some temporary serious injuries from acute radiation syndrome. The future predicted mortality from increases in cancer ... black lung etc. in its comparison. "Nuclear Power Prevents More Deaths Than It Causes , Chemical & Engineering News". Cen.acs. ... resulting in 9 crew fatalities and 83 injuries. The Fukushima Daiichi nuclear accident was caused by the 2011 Tohoku earthquake ...
"The impact of cannabis on your lung". British Lung Association. June 2012. Archived from the original on 27 September 2013. ... Any episode of acute psychosis that accompanies cannabis use usually abates after six hours, but in rare instances, heavy users ... Combining alcohol with cannabis greatly increases the level of impairment and the risk of injury or death from accidents". The ... Acute effects while under the influence can sometimes include euphoria. Although some assert that cannabidiol (CBD), another ...
Utilizing the Fick principle, the ratio of blood flow in the lungs (Qp) and system circulations (Qs) can calculate the Qp:Qs ... The use of fluoroscopy requires radiopaque contrast, which in rare cases can lead to contrast-induced kidney injury (see ... Acute coronary syndromes: ST elevation MI (STEMI), non-ST Elevation MI (NSTEMI), and unstable angina Evaluation of coronary ... Lung Cellular and Molecular Physiology. 313 (4): L651-L658. doi:10.1152/ajplung.00133.2017. PMID 28839102. MedlinePlus Medical ...
Catherine Leroy, 60, French photojournalist known for her coverage of the Vietnam War in Life, lung cancer. Raja Rao, 97, ... June Allyson, 88, American actress, dancer and singer, pulmonary respiratory failure and acute bronchitis after a long illness ... Goldstein, Richard (July 17, 2006). "James Nicholas, 85, Leader in Treating Sports Injuries, Dies". The New York Times. ... Rudi Carrell, 71, Dutch-born TV entertainer most active in Germany, lung cancer. Dorothea Church, 83, African-American model, ...
However, inhaled A1AT may not reach the elastin fibers in the lung where elastase injury occurs. Further study is currently ... Kushner, Mackiewicz A (1993). The acute phase response: an overview. Acute-phase glycoproteins: molecular biology, biochemistry ... In the acute phase reaction, a further elevation is required to "limit" the damage caused by activated neutrophil granulocytes ... This suggests that A1AT may play an anti-inflammatory or tissue-protecting role outside the lungs. These antibodies are ...
Mark Ellyatt is reported to have suffered permanent lung damage; Pascal Bernabé (who was injured on his dive when a light on ... This is necessary to prevent inert gas bubble formation in the body tissues of the diver, which can cause severe injury. ... and possibly acute oxygen toxicity. The term is not in widespread use at present, as where the actual cause of blackout is ... equipped with a lung bag and soda lime filter for CO2 removal, in order to reuse the exhaled air. Only two of the above- ...
Cunha BA, Pherez FM, Durie N (July 2010). "Swine influenza (H1N1) and acute appendicitis". Heart & Lung. 39 (6): 544-6. doi: ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 11 November 2020. ... The presentation of acute appendicitis includes acute abdominal pain, nausea, vomiting, and fever. As the appendix becomes more ... Perman's sign: In acute appendicitis palpation in the left iliac fossa may produce pain in the right iliac fossa. While there ...
Jane Freeman, 81, Welsh actress (Last of the Summer Wine), lung cancer. Bill Hands, 76, American baseball player (Chicago Cubs ... injuries sustained in bomb explosion. Gilbert Baker, 65, American artist and gay activist, creator of the rainbow flag. Richard ... complications from acute bronchitis. August Englas, 92, Estonian wrestler, world champion (1953, 1954). Roy Fisher, 86, British ... Joanne Kyger, 82, American poet, lung cancer. Sven-Erik Magnusson, 74, Swedish musician (Sven-Ingvars), prostate cancer. Tomas ...
oxford) Radiation Pneumonitis, also known as Radiation Induced Lung Injury, describes the initial damage done to the lung ... Acute Interstitial Pneumonitis can result from many different irritants in the lungs and usually is resolved in under a month. ... Aspiration due to a drug overdose A lung injury after the inhalation of habitual gastric contents. The development of colonized ... "Farmer's lung" and "hot tub lung" are common names for types of hypersensitivity pneumonitis that result from exposure to some ...
Csillag, Ron (January 26, 2012). "Brilliant biochemist was an authority on the immunology of burn injury". The Globe and Mail. ... Sabri Godo, 82, Albanian politician, writer and scriptwriter, founder and president of the Republican Party of Albania, lung ... Tetsuzo Fuyushiba, 75, Japanese politician, Minister of Land, Infrastructure, Transport and Tourism (2006-2008), acute ... Sean Bonniwell, 71, American guitarist, singer and songwriter (The Music Machine), lung cancer. Howard P. Boyd, 97, American ...
How common is lung injury in acute liver failure and how does it impact outcomes? ... no acute respiratory distress syndrome, 10 d; mild acute respiratory distress syndrome acute lung injury, 12 d; moderate acute ... Conclusion: The prevalence of lung injury is relatively low in acute liver failure, where 21% fulfilled acute respiratory ... Lung Injury and Its Prognostic Significance in Acute Liver Failure. Vinod K. Audimoolam, MRCP; Mark J. W. McPhail, MBBS, MRCP, ...
Transfusion-related acute lung injury (TRALI) is the serious complication of transfusion of blood products that is ... It is often impossible to distinguish TRALI from acute respiratory distress syndrome (ARDS). The typical presentation of TRALI ... characterized by the rapid onset of excess fluid in the lungs. It can cause dangerous drops in the supply of oxygen to body ...
... Am J Respir Crit Care Med. 2019 Dec 1;200(11):1342 ...
Transfusion related acute lung injury (TRALI) is an adverse outcome of transfusion in which acute respiratory distress occurs ... No previous evidence of acute lung injury (ALI), such as circulatory overload or acute respiratory distress syndrome (ARDS) ... Transfusion related acute lung injury (TRALI) * Acronym TRALI coined in 1985 by Popovsky and Moore (Transfusion 1985;25:573) ... Inverse transfusion related acute lung injury refers to the recipient having antibodies against antigens in the donor, so ...
Methotrexate reduces acute lung injury in a murine model of sepsis. Josep Bringue, Raquel Guillamat-Prats, Eva Torrents, Mª ... Methotrexate reduces acute lung injury in a murine model of sepsis. Josep Bringue, Raquel Guillamat-Prats, Eva Torrents, Mª ... Methotrexate reduces acute lung injury in a murine model of sepsis. Josep Bringue, Raquel Guillamat-Prats, Eva Torrents, Mª ... Methotrexate reduces acute lung injury in a murine model of sepsis Message Subject (Your Name) has sent you a message from ...
Poisoned mice exhibited severe lung tissue lesions and edema, significant neutrophilic (PMNs) infiltration, and release of the ... leading to marked cell apoptosis in the lung tissues. TO901317 treatment reversed all these effects through inhibition of PQ- ... is a widely used herbicide with extremely high poisoning mortality mostly from acute lung injury (ALI) or progressive pulmonary ... Effects of TO901317 on lung W/D ratio and histopathological changes in lung tissues. The lung W/D ratio (a) and lung ...
These data support the proposal that inosine might represent a useful adjunct in the therapy of acute respiratory distress ... Inosine largely suppressed LPS-induced lung inflammation in vivo and reduced the toxicity of cytokines in lung cells in vitro. ... Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury Ann Surg. 2002 Apr;235(4):568- ... Objective: To investigate the effects of inosine on the acute lung inflammation induced by lipopolysaccharide (LPS) in vivo and ...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the clinical manifestations of severe lung damage ... Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest. 119:2898 ... Acute lung injury (ALI) and the more severe form, acute respiratory distress syndrome (ARDS), are the primary cause of ... Matute-Bello G, Frevert CW and Martin TR: Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 295:L379-L399 ...
Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25-40%. Despite recent advances of our ... Activated protein C inhalation: A novel therapeutic strategy for acute lung injury DOI: 10.12659/MSM.881789 ...
Acute lung injury after mechanical circulatory support implantation in patients on extracorporeal life support: an unrecognized ... Acute Lung InjuryAdultAgedAnalysis of VarianceCardiac Surgical ProceduresExtracorporeal Membrane OxygenationFemaleHeart-Assist ... We observed early acute lung injury (ALI) after a switch from veno-arterial extracorporeal life support (VA-ECLS) to long-term ... TY - JOUR T1 - Acute lung injury after mechanical circulatory support implantation in patients on extracorporeal life support: ...
... medical journal Stem Cells that adult stem cells isolated from the bone marrow of mice can protect against acute lung injury. ... Acute lung injury is a major cause of death that can be caused by several conditions. Viral infections such as SARS, blunt for ... The scientists reasoned that since in acute lung injury most of the damage occurs to the cells lining the blood vessels, ... medical journal Stem Cells that adult stem cells isolated from the bone marrow of mice can protect against acute lung injury. ...
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... in children with acute lung injury, and also in a mouse model of acute lung injury induced by the endotoxin lipopolysaccharide ... plays a vital role in acute lung injury. However, the role of miR-30b-5p in the pathogenesis of acute lung injury is not clear ... acute lung injury inflammation and suggested that miR-30b-5p might be an important therapy target in children with acute lung ... and IL-8 were increased in lung tissue, serum, and bronchoalveolar lavage fluid of mice with acute lung injury induced by LPS. ...
Acute lung injury, Acute respiratory distress syndrome, Surfactant Persistent URL doi.org/10.1097/00075198-200402000-00004, hdl ... Surfactant therapy for acute lung injury/acute respiratory distress syndrome. Publication. Publication. Current Opinion in ... Haitsma, J.J, Papadakos, P.J, & Lachmann, B.F. (2004). Surfactant therapy for acute lung injury/acute respiratory distress ... Purpose of review: Currently, three phase III surfactant replacement trials for acute lung injury (ALI)/acute respiratory ...
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Piza, F., Carvalho, F., Li, H. et al. Influenza A (H1N1): the first hit for transfusion-related acute lung injury?. Crit Care ... Toy P, et al.: Transfusion-related acute lung injury: definition and review. Crit Care Med 2005, 33: 721-726. 10.1097/01.CCM. ... Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities [1]. A two-hit hypothesis ... Kleinman S, et al.: Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. ...
Probiotic agent Saccharomyces boulardii reduces the incidence of lung injury in acute necrotizing pancreatitis induced rats. J ... Probiotic agent Saccharomyces boulardii reduces the incidence of lung injury in acute necrotizing pancreatitis induced rats. ... Probiotic agent Saccharomyces boulardii reduces the incidence of lung injury in acute necrotizing pancreatitis induced rats. ...
Male Sprague-Dawley rat lungs were injured by intratracheal instillation of LPS. Rats were treated with Semen Cassiae or ... Acute lung injury (ALI) is an inflammatory disorder. Semen Cassiae has potent anti-inflammatory activities. The aim of our ... Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is severe disorder of lungs with high mortality [1, 2]. The ... Glutamine protects ischemia-reperfusion induced acute lung injury in isolated rat lungs. Pulm Pharmacol Ther. 2011;24(1):153-61 ...
Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory ... Acute lung injury (ALI) and its more severe form, acute respiratory syndrome (ARDS) is one of the common organ dysfunction ... Acute lung injury (ALI) and its more severe form, acute respiratory syndrome (ARDS) is one of the common organ dysfunction ... Diagnosis of acute lung injury or acute respiratory distress syndrome according to the American-European Consensus Conference ...
Histone Deacetylase 7 in Murine Gram-Negative Acute Lung Injury. ... Histone Deacetylase 7 in Murine Gram-Negative Acute Lung Injury ...
Kleinman S, Gajic O, Nunes E. Promoting recognition and prevention of transfusion-related acute lung injury. Critical care ... Kleinman, S., Gajic, O., & Nunes, E. (2007). Promoting recognition and prevention of transfusion-related acute lung injury. ... Kleinman, S, Gajic, O & Nunes, E 2007, Promoting recognition and prevention of transfusion-related acute lung injury, ... Promoting recognition and prevention of transfusion-related acute lung injury. In: Critical care nurse. 2007 ; Vol. 27, No. 4. ...
Controlling target gene expression is a vital step in the procedure of gene therapy upon acute lung injury (ALI). Excessive ... Controlling target gene expression is a vital step in the procedure of gene therapy upon acute lung injury (ALI). Excessive ... Automatic regulation of NF-kappaB by pHSP70/IkappaBalpham to prevent acute lung injury in mice ... Automatic regulation of NF-kappaB by pHSP70/IkappaBalpham to prevent acute lung injury in mice. ...
Background:Acute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. Amplified ... abstract = "Background:Acute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. ... N2 - Background:Acute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. ... AB - Background:Acute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. ...
Acute transfusion reactions present as adverse signs or symptoms during or within 24 hours of a blood transfusion. The most ... Acute transfusion reactions caused by ABO antibodies, transfusion-related acute lung injury (TRALI; from donors antibodies), ... Transfusion-related acute lung injury. Neutrophils are the effector cells that adhere to the pulmonary endothelium to increase ... Transfusion-related acute lung injury: a clinical review. Lancet. 2013 Sep 14. 382 (9896):984-94. [QxMD MEDLINE Link]. ...
Transfusion related acute lung injury: a case report. Authors: Castro, Javier Alcazar. Aspiros, Alejandro Zárate. Cuellar, ... Transfusion Related Acute Lung Injury (TRALI) is one of the most serious complications of blood transfusion. All blood ... Transfusion related acute lung injury: a case report. International Journal of Research in Medical Sciences. 2019 Jan; 7(1): ... once the rest of the possible causes of acute lung injury have been ruled out. The differential diagnosis of a patient who ...
Mice were intratracheally instilled with lipopolysaccharide (LPS) to establish acute lung injury. N6-adenosine (m6A) ... ultimately improving lung injury in the ALI model mice. Mechanism studies demonstrated that the knockout of methyltransferase 3 ... We found that miR-29a-3p was down-regulated in plasma of ARDS patients and lung tissue of ALI model mice, and miR-29a-3p agomir ... in the lungs, reducing alveolar epithelial cell PANoptosis as evaluated by the downregulation of Z-DNA binding protein 1 (ZBP1 ...
Background: Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related death in the United ... N2 - Background: Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related death in the United ... AB - Background: Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related death in the United ... Characterizing the epidemiology of postoperative transfusion-related acute lung injury. Anesthesiology. 2015;122(1):12-20. ...
... Front. Biosci. (Landmark Ed) 2012, 17(2 ... and other genetic variations have been associated with acute and chronic lung disease throughout life in several populations ... inflammatory processes and surfactant dysfunction are well described events that occur in patients with acute or chronic lung ... Pulmonary surfactant, a lipoprotein complex, maintains alveolar integrity and plays an important role in lung host defense, and ...
... is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood. Infants can also ... Lung damage, such as a collapsed lung (also called pneumothorax) due to injury from the breathing machine needed to treat the ... ARDS can be caused by any major direct or indirect injury to the lung. Common causes include:. *Breathing vomit into the lungs ... Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the ...
Radiologic patterns of lung disease associated with occupational exposures on chest radiograph and chest CT. ... Smoking-related lung disease. Ground-glass opacity. Hypersensitivity pneumonitis. Acute or subacute inhalational lung injury. ... Acute or accelerated silicosis. Acute or subacute lung injury. Infection. Pulmonary hemorrhage. Malignancy. Organizing ... Smoking-related lung disease. Alpha-1 antitrypsin deficiency. Mosaic attenuation/air trapping. Bronchiolitis from toxic fume or ...
  • [ 5 ] The pathogenesis leading to deterioration in gas exchange in ALF patients can be multifactorial and due to hydrothorax, atelectasis, acute respiratory distress syndrome (ARDS), and impaired compliance of the respiratory system in case of raised intra-abdominal pressure or chest wall edema. (medscape.com)
  • It is often impossible to distinguish TRALI from acute respiratory distress syndrome (ARDS). (wikipedia.org)
  • Acute Respiratory Distress Syndrome (ARDS) is the major cause of respiratory insufficiency in patients and is associated with high mortality and morbidity. (ersjournals.com)
  • Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the clinical manifestations of severe lung damage and respiratory failure. (spandidos-publications.com)
  • Acute lung injury (ALI) and the more severe form, acute respiratory distress syndrome (ARDS), are the primary cause of mortality and morbidity in intensive care ( 1 , 2 ). (spandidos-publications.com)
  • Purpose of review: Currently, three phase III surfactant replacement trials for acute lung injury (ALI)/acute respiratory distress syndromes (ARDS) patients are underway. (eur.nl)
  • Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is severe disorder of lungs with high mortality [ 1 , 2 ]. (biomedcentral.com)
  • Acute lung injury (ALI) and its more severe form, acute respiratory syndrome (ARDS) is one of the common organ dysfunction associated with septic shock. (druglib.com)
  • Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood. (medlineplus.gov)
  • ARDS can be caused by any major direct or indirect injury to the lung. (medlineplus.gov)
  • The occurrence of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) after thoracic surgery are perplexing and persistent problems. (duke.edu)
  • 2 TRALI isn't physiologically different from other forms of ALI, including acute respiratory distress syndrome (ARDS). (elitelearning.com)
  • Pulmonary vascular leakage occurs early in acute respiratory distress syndrome (ARDS). (thelancet.com)
  • Acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS) is featured by intensive inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis. (greenmedinfo.com)
  • Recruitment maneuvers (RM), consisting of sustained inflations at high airway pressures, have been advocated as an adjunct to mechanical ventilation in acute respiratory distress syndrome (ARDS). (umn.edu)
  • We postulate that the variant MBL-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ARDS). (cdc.gov)
  • 1 Introduction Acute lung injury (ALI) is one of the most common complications following extracorporeal circulation (ECC), and the mortality rate in its severe form, acute respiratory distress syndrome (ARDS), is very high (Ng et al. (docksci.com)
  • This is an open label phase II study of treatment with LEAF-4L6715 in patients who experience severe acute respiratory distress syndrome (ARDS) due to COVID-19, Sepsis or other Causes. (clinicaltrials.gov)
  • Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening diseases in critically ill patients that continue to increase rapidly. (puuma.org)
  • To enable discovery of new specific therapeutic targets and to effectively manage sepsis-induced ALI/ARDS (sepsis-ALI/ARDS), a better understanding of injury-causing pathogenic mechanisms is required. (puuma.org)
  • An emerging theory of sepsis-induced ALI (sepsis-ALI) and ARDS (sepsis-ARDS) is that lung damage is due to the release of nuclear proteins from cell death such as neutrophil extracellular traps (NETs) and pyroptosis in the host response to infection. (puuma.org)
  • These patients appear to be at increased risk of respiratory complications including Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). (cliniexpert.com)
  • The purpose of the present study was to design and develop an experimental porcine model of ARDS by inducing lung injury with intrapulmonary administration of sodium polyacrylate (SPA). (springeropen.com)
  • This model may be useful to study ARDS caused by epithelial injury and inflammation. (springeropen.com)
  • Acute respiratory distress syndrome (ARDS) is characterized by severe hypoxic respiratory failure and is associated with high mortality and morbidity [ 1 ]. (springeropen.com)
  • Despite advances in the understanding and treatment of ARDS, the mechanisms of alveolar epithelial injury are not well understood. (springeropen.com)
  • In ARDS, surfactant depletion and inactivation decreases alveolar stability, exacerbating or precipitating alveolar collapse, lung atelectasis, and hypoxia. (springeropen.com)
  • Debate about the optimal way to set positive end-expiratory pressure (PEEP) in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) continues, because existing studies have not been sufficiently large to detect small differences. (medscape.com)
  • Low tidal volume ventilation has become the standard in lung protective ventilation for treating patients with ALI or ARDS. (medscape.com)
  • In contemporary reports, approximately 30% of patients with acute respiratory distress syndrome (ARDS) will die 1 and up to 70% of survivors have persistent significant disability. (bmj.com)
  • Complete Recovery After of Acute Respiratory Distress Syndrome (ARDS) May be Rare . (yahoo.com)
  • Survivors of acute respiratory distress syndrome (ARDS) remain physically and emotionally weak even five years after recovering, says new study. (yahoo.com)
  • The goal of supportive care is getting enough oxygen into the blood and delivered to your body to prevent damage and removing the injury that caused ARDS to develop. (yahoo.com)
  • Research focuses on the effects of cigarette smoke and e-cigarette aerosols on susceptibility to acute respiratory distress syndrome (ARDS), a major cause of respiratory failure in critically ill patients. (ucsf.edu)
  • Viral-induced acute respiratory distress syndrome (ARDS), including those caused by SARS CoV-1 and MERS are characterized by a massive systemic pro-inflammatory state. (clinicaltrials.gov)
  • The acute lung injury and acute respiratory distress syndrome (ARDS) literature has some evidence to that effect, they noted. (medpagetoday.com)
  • Although common, aspiration can lead to a range of diseases, including chronic cough, reflux-aggravated asthma, chemical pneumonitis, infectious pneumonia, or acute respiratory distress syndrome (ARDS) with significant morbidity and mortality. (rtmagazine.com)
  • Severe coronavirus disease 2019 (COVID-19) infection leads to multifactorial acute respiratory distress syndrome (ARDS), with little therapeutic success. (cell.com)
  • Many patients with acute respiratory failure fulfill the diagnosis of Acute Respiratory Distress Syndrome (ARDS), forming a very heterogeneous population. (signavitae.com)
  • Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses. (selleckchem.com)
  • In the pre-COVID-19 scenario, HFNC was being administered to patients with acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). (pharmiweb.com)
  • Acute respiratory distress syndrome (ARDS) is classically described as noncardiogenic pulmonary edema, thought to be secondary to increased pulmonary capillary permeability. (medscape.com)
  • MTX can control the proinflammatory cascade activated in the early stages of lung inflammation, reducing lung injury in a murine model. (ersjournals.com)
  • To investigate the effects of inosine on the acute lung inflammation induced by lipopolysaccharide (LPS) in vivo and on the activation and cytotoxicity elicited by proinflammatory cytokines on human lung epithelial (A549) cells in vitro. (nih.gov)
  • Inosine largely suppressed LPS-induced lung inflammation in vivo and reduced the toxicity of cytokines in lung cells in vitro. (nih.gov)
  • Pulmonary surfactant, a lipoprotein complex, maintains alveolar integrity and plays an important role in lung host defense, and control of inflammation. (imrpress.com)
  • This may involve medicines to treat infections, reduce inflammation, and remove fluid from the lungs. (medlineplus.gov)
  • Acute lung injury (ALI) is associated with systemic inflammation and cardiovascular dysfunction. (elsevier.com)
  • Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal acute lung injury (ALI) by driving hypercytokinemia and aggressive inflammation through mechanisms that remain elusive. (jci.org)
  • In SARS-CoV/macaque models, we determined that anti-spike IgG (S-IgG), in productively infected lungs, causes severe ALI by skewing inflammation-resolving response. (jci.org)
  • The aim of the present study is to evaluate the contribution of mitogen-activated protein kinase 1-3 (MAPK3/MAPK1) in a model of acute lung inflammation in mice. (unime.it)
  • Furthermore, carrageenan induced lung apoptosis (Bax and Bcl-2 expression) as well as nitrotyrosine formation, NF-κB activation, and pJNK expression, as determined by immunohistochemical analysis of lung tissues and the degree of lung inflammation and tissue injury (histological score). (unime.it)
  • Reduction in lung inflammation was associated with decline in pulmonary edema as the total protein content in the BALF was found to be decreased substantially. (phcogres.com)
  • Differential modulation of LTA 4 H by 4MDM was probed in a murine model of acute lung inflammation, which showed that 4MDM modulates the host neutrophilic response independent of clearing PGP. (nature.com)
  • Nobiletin-ameliorated lipopolysaccharide-induced inflammation in acute lung injury. (greenmedinfo.com)
  • Nobiletin-Ameliorated Lipopolysaccharide-Induced Inflammation in Acute Lung Injury by Suppression of NF-κB Pathway In Vivo and Vitro. (greenmedinfo.com)
  • NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury. (ac.ir)
  • University of Calgary researchers at the Cumming School of Medicine (CSM), led by Drs. Donna Senger, PhD, Paul Kubes, PhD, and Stephen Robbins, PhD, have discovered a new way to stop harmful inflammation in the lungs due to sepsis and injury. (ucalgary.ca)
  • Inflammation caused by injury, and other diseases, can also create this harmful response. (ucalgary.ca)
  • Meanwhile, Kubes, a specialist in inflammation, was investigating why white blood cells collect in the lungs. (ucalgary.ca)
  • They've now patented two drug-like molecules that can prevent lung and liver damage due to inflammation. (ucalgary.ca)
  • Lung Injury, bacterial pneumonia and sepsis including their connections to innate immunity, host-pathogen interactions, and inflammation. (bu.edu)
  • The Division of Cell Biology is comprised of 15 full time primary faculty members with wet lab-based multi-disciplinary research programs focused broadly on lung injury, inflammation, cell biology, immunology, development, remodeling, repair and lipid mediator biology. (nationaljewish.org)
  • Resolution of acute inflammation is an active process under the control of specific chemical mediators. (rtmagazine.com)
  • We are also interested in the factors that shape repair and resolution following injury, specifically factors derived from hematopoietic cells such as platelets and red blood cells that can influence the course of inflammation. (upmc.edu)
  • Loss of Red cell Chemokine Scavenging Promotes Transfusion Related Lung Inflammation. (upmc.edu)
  • As a result, neutrophils upregulate the expression of cytokines and proteases that are responsible for inducing systemic inflammation and injury to epithelial and endothelial cells. (cell.com)
  • Song W , Zhang T , Yang N , Zhang T , Wen R , Liu C . Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1. (wjgnet.com)
  • Wei Z , Liu J , Xie H , Wang B , Wu J , Zhu Z . MiR-122-5p Mitigates Inflammation, Reactive Oxygen Species and SH-SY5Y Apoptosis by Targeting CPEB1 After Spinal Cord Injury Via the PI3K/AKT Signaling Pathway. (wjgnet.com)
  • Interstitial lung diseases lead to deposition of scar tissue within the lung as well as inflammation in the lung substance. (umms.org)
  • Transfusion-related acute lung injury (TRALI) is the serious complication of transfusion of blood products that is characterized by the rapid onset of excess fluid in the lungs. (wikipedia.org)
  • Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities [ 1 ]. (biomedcentral.com)
  • We describe a fatal TRALI in a patient with influenza A (H1N1), suggesting a relationship between a first-hit lung injury followed by the second lung impairment after blood transfusions. (biomedcentral.com)
  • Transfusion-related acute lung injury (TRALI) manifests as rapid onset of shortness of breath, hypoxemia, and rales, without signs of acute cardiogenic pulmonary edema and fever. (medscape.com)
  • Transfusion Related Acute Lung Injury (TRALI) is one of the most serious complications of blood transfusion. (who.int)
  • Because the incidence of TRALI is increasing in the U.S., the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health crafted a consensus definition. (elitelearning.com)
  • Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion. (nataonline.com)
  • In immunogenic TRALI transfused donor antibodies - mostly from plasma products - are responsible for causing acute lung insufficiency. (nataonline.com)
  • TRANSFUSION-RELATED acute lung injury (TRALI) can cause profound hypoxemia abruptly after the administration of blood products. (asahq.org)
  • Significant increases in both DIO2 gene and D2 protein expression were observed in lung tissues from murine ALI models (LPS- and ventilator-induced lung injury), with expression directly increasing with the extent of lung injury. (arizona.edu)
  • Mechanical ventilation (MV) can lead to ventilator-induced lung injury secondary to trauma and associated increases in pulmonary inflammatory cytokines. (elsevier.com)
  • [ 1 ] This has been shown to reduce the development of ventilator-induced lung injury. (medscape.com)
  • [ 2 , 3 ] Knowing the optimal level of PEEP would help to further reduce ventilator-induced lung injury by preventing alveolar injury from cyclic opening and closing. (medscape.com)
  • A case is described of a 29-year-old female who presented with acute hypoxic respiratory failure due to acute eosinophilic pneumonia, associated with the use of electronic cigarettes to vape tetrahydrocannabinol (THC), together with the contemporary clinical understanding of the syndrome of electronic-cigarette associated lung injury (EVALI). (jccm.ro)
  • Attention is drawn to acute eosinophilic pneumonia as a potential consequence of vaping-associated lung injury to understand the diagnostic evaluations and therapeutic interventions for acute eosinophilic pneumonia associated with vaping THC. (jccm.ro)
  • OBJECTIVES: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate is involved in the regulation of vascular permeability and immune responses. (edu.au)
  • Pneumonia-induced lung hyperpermeability was reduced in SphK1 mice compared with wild-type mice. (edu.au)
  • Expression of sphingosine kinase 1 in macrophages recruited to inflamed lung areas in pneumonia was observed in murine and human lungs. (edu.au)
  • CONCLUSIONS: Our data suggest that targeting the sphingosine kinase 1-/sphingosine-1-phosphate-/sphingosine-1-phosphate receptor 2-signaling pathway in the lung may provide a novel therapeutic perspective in pneumococcal pneumonia for prevention of acute lung injury. (edu.au)
  • All patients had a clinical diagnosis of pneumonia and biopsies revealed lung damage in the majority. (elsevier.es)
  • Inhibition of the Lipoxin A4 and Resolvin D1 Receptor Impairs Host Response to Acute Lung Injury Caused by Pneumococcal Pneumonia in Mice. (ucsf.edu)
  • It is recognized as potential cures and therapies in cancer, replacing or fixing damaged organs, such as in spinal cord injury, or pneumonia. (greenprophet.com)
  • These pathogens are not specific for tsunami lung, but are reported causative agents for pneumonia after near-drowning. (who.int)
  • 1 After the initial rush of patients with injury after the Great Hanshin-Awaji earthquake in 1995, the number of respiratory diseases, largely pneumonia, increased about 4.5-fold. (who.int)
  • 3 Necrotizing pneumonia and pulmonary abscesses seen by the survivors of tsunamis were named tsunami lung. (who.int)
  • Abstract: The signaling pathway for tumor necrosis factor-α (TNF-α) and its receptors is up-regulated during extracorporeal circulation (ECC), and recruits blood neutrophil into the lung tissue, which results in acute lung injury (ALI). (docksci.com)
  • In a further abstract/poster presented at AAAAI/WAO Joint Congress, a pooled, post-hoc meta-analysis of data from the MENSA and MUSCA studies, mepolizumab showed improvements in lung function of patients with severe eosinophilic asthma, measured by morning peak expiratory flow (AM PEF), compared with placebo. (gsk.com)
  • Transpulmonary Pressure Measurement: The Key to Protecting the Lung, or an Abstract Waste of Time? (medscape.com)
  • Poisoned mice exhibited severe lung tissue lesions and edema, significant neutrophilic (PMNs) infiltration, and release of the proinflammatory cytokines tumor necrosis factor- α (TNF- α ) and interleukin-1 β (IL-1 β ). (hindawi.com)
  • Scientists at the University of Illinois reported today in the international medical journal Stem Cells that adult stem cells isolated from the bone marrow of mice can protect against acute lung injury. (cellmedicine.com)
  • Lung, heart and liver tissues were collected from sample mice of every group 12 h after LPS treatment for further study. (polyplus-transfection.com)
  • Vivo experiments revealed that construction naming pHSP70/IkappaBalpham reduced LPS-induced lung injury and the secretion of inflammatory factors from lungs, hearts, and livers of sample mice in a LPS dose-dependent manner. (polyplus-transfection.com)
  • Furthermore, adenosine prevented weight loss, tachycardia, and compromised lung function in E. coli-exposed mice. (elsevier.com)
  • Accordingly, treatment with adenosine or ATPγS increased oxygen saturation and reduced histopathological signs of lung injury in mice exposed to E. coli. (elsevier.com)
  • The result demonstratedthat LPS induced obvious lung injury characterized by alveolar damage, neutrophil infiltration and lung edema as well as the reduction of the survival rate of mice, which were totally reversed by melatonin pretreatment. (greenmedinfo.com)
  • Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice. (unime.it)
  • Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent adhesion molecule expression (I-CAM and P-selectin), lipid peroxidation, and increased production of tumour necrosis factor-α, (TNF-α) and interleukin-1β (IL-1β). (unime.it)
  • The aim of this study was to evaluate the effects of single oral doses of D-005 (a lipid extract obtained from the fruit oil of Acrocomia crispa) on LPS-induced acute lung injury (ALI) in mice. (uchile.cl)
  • The present work was designed to evaluate the beneficial potential of hydroalcoholic extract of the roots of C. dignea against hydrochloric acid (HCl)‑induced acute lung injury in mice. (phcogres.com)
  • Mice were then analyzed for infiltration of inflammatory cells in bronchoalveolar lavage fluid (BALF) and oxidative stress markers in the lung tissue. (phcogres.com)
  • Our data suggest that hydroalcoholic extract of Caesalpinia digyna roots constitute the phytochemicals that can protect against HCl‑induced acute lung injury in mice. (phcogres.com)
  • Mice with reduced levels of DIO2 expression (by silencing RNA) demonstrated reduced thyroxine levels in plasma and increased lung injury (increased bronchoalveolar lavage proteinandleukocytes), suggesting a protective role for DIO2 in ALI. (arizona.edu)
  • Thus, this study aimed to investigate the anti-inflammatory response of NOB in lipopolysaccharide (LPS)-stimulated A549 cells and LPS-induced acute lung injury (ALI) in mice. (greenmedinfo.com)
  • Role of survivin in acute lung injury: epithelial cells of mice and humans. (ac.ir)
  • Aerosolized Vitamin E Acetate Causes Oxidative Injury in Mice and in Alveolar Macrophages. (ucsf.edu)
  • Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice. (ucsf.edu)
  • Local Delivery of Azithromycin Nanoformulation Attenuated Acute Lung Injury in Mice. (wjgnet.com)
  • Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury. (upmc.edu)
  • CD36 and Fyn kinase mediate malaria-induced lung endothelial barrier dysfunction in mice infected with Plasmodium berghei. (jhu.edu)
  • 48 h later, the animals were sacrificed and samples of lung tissue, bronchoalveolar lavage fluid and blood were collected. (ersjournals.com)
  • In addition, MTX significantly reduces the expression of proinflamatory markers in lung tissue. (ersjournals.com)
  • Most of these patients died of acute lung injury (ALI) or progressive pulmonary fibrosis, because PQ tends to accumulate in lung tissue through the polyamine uptake system and so the pulmonary concentration becomes much higher than that in plasma and other organs [ 2 ]. (hindawi.com)
  • Viral infections such as SARS, blunt for tissue trauma, and bacteria sepsis have all been associated with lung injury. (cellmedicine.com)
  • Tumor necrosis factor α (TNF-α), interleukin (IL)-1β and IL-6 in serum and lung tissue were analyzed by enzyme-linked immunosorbent assay. (elsevier.com)
  • Bilateral lysis of aortic saddle thrombus with early tissue plasminogen activator (BLASTT): a prospective, randomized, placebo-controlled study in feline acute aortic thromboembolism. (ncsu.edu)
  • In ex-vivo studies, we first established that IFN-beta-1a induced CD73 up-regulation in cultured human lung tissue samples. (thelancet.com)
  • Although lung tissue inflammatory cytokine production was found to vary regionally throughout the LPS-injured lung, S1P did not alter the expression pattern. (elsevier.com)
  • When workers inhale crystalline silica, the lung tissue reacts by developing fibrotic nodules and scarring around the trapped silica particles [Silicosis and Silicate Disease Committee 1988]. (cdc.gov)
  • CAY10500 pretreatment slightly reduced leukocyte infiltration in lungs, but did not change the wet/dry ratio in the lung tissue. (docksci.com)
  • Lung tissue samples were taken for histopathological examination. (balkanmedicaljournal.org)
  • Branching morphogenesis is a key process essential for lung and other organ development in which cellular and tissue architecture branch out to maximize surface area. (jbc.org)
  • Human postmortem lung tissue, human blood-derived macrophages, and pulmonary microvascular endothelial cells. (edu.au)
  • Lung tissue histopathology and immunohistochemical expression of survivin and proliferating cell nuclear antigen (PCNA) were also examined. (ac.ir)
  • Electron microscopy of lung tissue from SPA-treated animals revealed injury to the alveolar epithelium and basement membranes, including intra-alveolar neutrophils and fibrin on the alveolar surface and intravascular fibrin (microthrombosis). (springeropen.com)
  • 10 Third, MSCs play an important role in the repair and regeneration of lung tissue following injury. (bmj.com)
  • Autoimmune and allergic diseases are also associated to the accumulation of protons in the extracellular space at the sites of tissue injury. (hindawi.com)
  • Thoracic Visceral Adipose Tissue Area and Pulmonary Hypertension in Lung Transplant Candidates. (upenn.edu)
  • The high expression of IL-1β in the first week after injection was accompanied by local increase of the proinflammatory cytokines IL-6 and TNF-α and a vigorous acute inflammatory tissue response with evidence of tissue injury. (jci.org)
  • This was associated with severe progressive tissue fibrosis in the lung, as shown by the presence of myofibroblasts, fibroblast foci, and significant extracellular accumulations of collagen and fibronectin. (jci.org)
  • These data directly demonstrate how acute tissue injury in the lung, initiated by a highly proinflammatory cytokine, IL-1β, converts to progressive fibrotic changes. (jci.org)
  • Dr. Raj's primary clinical interest and primary focus of clinical research is interstitial lung diseases including idiopathic pulmonary fibrosis, other idiopathic interstitial lung diseases, drug induced interstitial lung diseases, interstitial lung disease associated with connective tissue diseases including scleroderma, rheumatoid arthritis, dermatomyositis etc., sarcoidosis, hypersensitivity pneumonitis and other miscellaneous interstitial lung diseases. (stanford.edu)
  • and (2) to analyze the aerosol properties and chemical composition of aerosolized vitamin E acetate (i.e., a chemical already suspected to be hazardous) and other potential hazardous constituents identified from social media monitoring in Aim 1 to determine their effects in lung tissue. (fda.gov)
  • Paraquat (PQ) is a widely used herbicide with extremely high poisoning mortality mostly from acute lung injury (ALI) or progressive pulmonary fibrosis. (hindawi.com)
  • RNA sequencing of transplant-stage idiopathic pulmonary fibrosis lung reveals unique pathway regulation. (upenn.edu)
  • These specialties have translational connections to acute lung injury, asthma, COPD, pulmonary fibrosis, cystic fibrosis and lung cancer. (nationaljewish.org)
  • 1 Since bleomycin causes an inflammatory process that finally results in pulmonary fibrosis, it is currently used in experimental studies to produce oxidant induced inflammatory and fibrotic lesions in the lung interstitium of various animal species. (bmj.com)
  • 5, 11 Other authors have reported a significant improvement in lung function after treatment with a high dose of NAC combined with a low dose of steroids in patients with idiopathic pulmonary fibrosis. (bmj.com)
  • Dr. Raj is the principal investigator and co-investigator on multiple clinical trials evaluating new therapies for treating idiopathic pulmonary fibrosis and pulmonary fibrosis/interstitial lung disease from other etiologies. (stanford.edu)
  • Altered inflammatory processes and surfactant dysfunction are well described events that occur in patients with acute or chronic lung disease that can develop secondary to a variety of insults. (imrpress.com)
  • Genetic variants of surfactant proteins, including single nucleotide polymorphisms, haplotypes, and other genetic variations have been associated with acute and chronic lung disease throughout life in several populations and study groups. (imrpress.com)
  • Predictors of mortality include older age and chronic lung disease. (who.int)
  • We discovered that by targeting this molecule we can stop the ill effects of sepsis, acute lung injury and death," says Kubes, the director of the Snyder Institute for Chronic Diseases at the CSM and professor in the Department of Physiology and Pharmacology. (ucalgary.ca)
  • For acute chronic respiratory failure, if the patient is completely stable, he/she is easily discharged after a few days or weeks, depending on his/her condition. (yahoo.com)
  • IL-1β is one of a family of proinflammatory cytokines thought to be involved in many acute and chronic diseases. (jci.org)
  • The onset of acute psoriasis and the exacerbation of chronic psoriasis are often associated with a history of bacterial infection. (jimmunol.org)
  • Specifically, we explore the role of primary immunodeficiency in certain difficult-to-treat chronic lung diseases, such as COPD, emphysema and asthma . (hopkinsmedicine.org)
  • chronic obstructive pulmonary disease (COPD) and environmental causes of lung disease, including allergens and particulate matter. (hopkinsmedicine.org)
  • These diseases which attack the airways of the lung and lung substance itself are common causes of shortness of breath, chronic coughing, pulmonary infections and need for frequent medical care. (umms.org)
  • 3.8 million premature deaths annually from noncommunicable diseases including stroke, ischaemic heart disease, chronic obstructive pulmonary disease (COPD) and lung cancer are attributed to exposure to household air pollution. (who.int)
  • By reducing air pollution levels, countries can reduce the burden of disease from stroke, heart disease, lung cancer, and both chronic and acute respiratory diseases, including asthma. (who.int)
  • Hypoxemia is a feared complication of acute liver failure, and high oxygen requirements will frequently lead to removal of patients from the transplant list. (medscape.com)
  • As data regarding the prevalence and outcome of acute respiratory distress syndrome in acute liver failure are scant and hypoxemia being a commonly encountered systemic complication, we analyzed radiological, gas exchange, and ventilator data in consecutive patients admitted with acute liver failure. (medscape.com)
  • Acute liver failure patients receiving mechanical ventilation admitted between January 2007 and February 2011 were included. (medscape.com)
  • Two hundred acute liver failure patients were admitted during the study period of whom 148, median age 39 years (16-74 yr), were included. (medscape.com)
  • Acute liver failure (ALF) is an uncommon condition in which a primary liver insult results in rapid deterioration of liver function in association with coagulopathy and alteration in the mental status of a previously healthy individual without underlying liver disease (excluding patients with acute presentations of Wilson disease or autoimmune hepatitis). (medscape.com)
  • In addition, patients may have signs and symptoms that mimic severe vaso-occlusive crisis (ie, pain, fever, and acute chest syndrome), as well as profound anemia, often with reticulocytopenia. (medscape.com)
  • Transfusion-related acute lung injury occurs in 1:2,500 patients receiving a transfusion during anesthesia and is fatal in 5% of cases. (asahq.org)
  • Increased DIO2 expression may dampen the ALI inflammatory response, thereby strengthening the premise that thyroid hormone metabolismis intimately linked to the integrated response to inflammatory injury in critically ill patients. (arizona.edu)
  • One hundred patients with acute lung injury at 24 hours after cardiac surgery with cardiopulmonary bypass and 112 patients without acute lung injury as controls were included. (medscitechnol.com)
  • TD-0903 could provide benefit to hospitalized patients by preventing the progression of lung hyperinflammation and reducing the requirement for, or the duration of, assisted ventilation. (cliniexpert.com)
  • Janus kinase inhibitors have the potential to inhibit a broad set of immune-modulatory pathways that could prove to be effective in dampening the abnormal immune response that occurs in the lungs of some patients. (cliniexpert.com)
  • The nebulized formulation of our lung-selective inhaled JAK inhibitor will allow TD-0903 to be administered directly to the lung in a number of hospitalized settings, including patients who can breathe unaided in the ward, as well as in the ICU setting in patients who require non-invasive or mechanical ventilation. (cliniexpert.com)
  • This document is intended for clinicians taking care of hospitalised adult and paediatric patients with severe acute respiratory infection (SARI) when MERS-CoV infection is suspected. (who.int)
  • Usually seen in patients with acute pulmonary edema or acute lung injury. (yahoo.com)
  • On the other hand, observations made in samples of exhaled breath condensate from asthmatic patients revealed that acute asthma exacerbations are associated to the acidification of the airway [ 22 - 24 ]. (hindawi.com)
  • Similar findings were made in patients with acute lung injury [ 25 ]. (hindawi.com)
  • 4 ] [ 8 ] Some important considerations for the choice and dose of antithrombotic agents are the urgency for need of invasive procedures (e.g., for patients in the intensive care unit [ICU]), considerations for management of acute impairment of renal and liver function, and drug-drug interactions between investigational COVID-19 therapies and antithrombotic agents. (thieme-connect.de)
  • First, vagus nerve stimulation modulates bronchoconstriction, acute stimulation has demonstrated a marked improvement in Work of Breathing (WOB) as well as Forced Expiratory Volume (FEV1) in patients with severe respiratory distress due to airway reactivity. (clinicaltrials.gov)
  • Patients with e-cigarette or vaping-induced lung injury (EVALI) typically have a nonspecific clinical presentation characterized by a constellation of respiratory, gastrointestinal and constitutional symptoms. (rsna.org)
  • Imaging is important in patients with acute lung injury to ensure early detection. (rsna.org)
  • Pool chemical injuries led to patients discontinuing the drug. (kellersign.com)
  • This surgery is complex and there is a high risk that patients will develop severe complications afterwards, mainly lung or heart problems, leading to a longer hospital stay and higher hospital costs, and impacting greatly on recovery and. (hrb.ie)
  • Do lung Injured patients need a special rehabilitation program? (criticalcarecanada.com)
  • With autumn around the corner, I have begun seeing more patients with lung issues such as fall allergies, colds, and coughing, as well others seeking treatments to assist them through a grieving process or a letting go process. (pacherbs.com)
  • Five patients had acute lung injury and required ventilation and inotropic support. (scielo.org.za)
  • Three of the patients with acute lung injury subsequently died. (scielo.org.za)
  • The hypercapnia was unlikely only to have been due to lower tidal volumes (as part of the lung protective strategy), and may also have been caused by an increase in dead space (due to an increase in ventilatory frequency mandated by an attempt to maintain an acceptable minute ventilation) and possibly intrapulmonary arterial clots (which have been shown to occur in patients with acute lung injury). (scielo.org.za)
  • 1 The difference between the PeCO 2 and PaCO 2 (as a substitute for the proper Bohr equation which required average expired CO 2 ) supports the contention that the patients suffered from excessive high ventilation perfusion (dead space) lung units. (scielo.org.za)
  • OSMO showed us that when these patients remained uncontrolled on omalizumab and were then switched to mepolizumab, they experienced significant improvements - fewer symptoms, better lung function, improved asthma-related quality of life and fewer exacerbations. (gsk.com)
  • In addition, the meta-analysis we are presenting, which showed Nucala provides an early improvement, sustained over time in lung function compared with placebo, is further evidence supporting the effectiveness of this treatment in patients with severe eosinophilic asthma. (gsk.com)
  • Qu Y , Ding Y , Lu J , Jia Y , Bian C , Guo Y , Zheng Z , Mei W , Cao F , Li F . Identification of key microRNAs in exosomes derived from patients with the severe acute pancreatitis. (wjgnet.com)
  • Zhao M, Zhang H, Zhu G , Liang J , Chen N, Yang Y, Liang X, Cai H, Liu W. Association between overexpression of wip1 and prognosis of patients with non-small cell lung cancer Oncology Letters . (academictree.org)
  • The study from the Goethe-University Hospital Frankfurt, Germany found that blood clotting treatment algorithms for point-of-care testing compared to conventional laboratory analyses not only decreased blood transfusion requirements in cardiac surgery patients, but also were associated with improved outcomes, including decreased incidences of adverse events such as acute lung injury, renal failure, sepsis and thromboembolic complications. (asahq.org)
  • The ILD and lung transplantation programs are closely coordinated ensuring that the transplant option is available to patients with ILD. (umms.org)
  • In addition to traditional treatment with inhaled medicines and oxygen, we can now offer appropriate patients pulmonary rehabilitation, and in select cases lung volume reduction surgery and even lung transplantation. (umms.org)
  • While the study is young and the PLX treatment was used on only 7 patients who were suffering from Acute Respiratory Distress Syndrome, the future looks very bright for the company and for us. (greenprophet.com)
  • Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. (medscape.com)
  • The status and potential role of novel biological markers (biomarkers) that can help identify the patients at risk of organ injury or long-term complications following heatstroke. (cdc.gov)
  • Our main hypothesis is that MTX controls the inflammatory response and reduces the damage in the lung. (ersjournals.com)
  • Sepsis caused by LPS is characterized by an intense systemic inflammatory response affecting the lungs, causing acute lung injury (ALI). (semmelweis.hu)
  • In particular my main focus is the process by which the inflammatory response influences the development of acute lung injury within the Intensive Care unit. (imperial.ac.uk)
  • Aspirated gastric acid induces a chemical burn that triggers an acute inflammatory response. (rtmagazine.com)
  • Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, disrupts the alveolar-capillary barrier, triggering pulmonary vascular leak thus inducing acute lung injury (ALI). (elsevier.com)
  • Lung histopathology showed significant alveolar congestion, infiltration of the leukocytes in the airspace, and increased thickness of the alveolar wall in all ECC-treated groups. (docksci.com)
  • Necropsy revealed marked consolidation and congestion of the dorsal lung lobes in SPA-treated animals, with light-microscopy evidence of bronchiolar and alveolar spaces filled with neutrophilic infiltrate, proteinaceous debris, and fibrin deposition. (springeropen.com)
  • More recently we have begun studying e-cigarette aerosols and their toxicity to human lung cells, exposing cultures of alveolar and airway epithelia (derived from human lungs declined for transplantation) in a novel aerosol generating machine. (ucsf.edu)
  • 3- 5 Bleomycin induced lung fibrosis appears to be the consequence of a primary inflammatory lesion characterised by an accumulation of alveolar macrophages and neutrophils in the lower respiratory tract. (bmj.com)
  • In this regard the high PEEP may have contributed to intra-alveolar vessel occlusion, although the effect of PEEP is to a large extent buffered by poor compliance of the lungs. (scielo.org.za)
  • Acute exposure to higher vapor concentrations may cause severe pulmonary edema and injury to the alveolar walls of the lung and death. (cdc.gov)
  • Bio Dr. Rishi Raj is an Clinical Professor of Medicine at Stanford University and directs the Interstitial Lung Disease program at Stanford. (stanford.edu)
  • He specializes in the diagnosis and treatment of interstitial lung diseases and has practiced pulmonary and critical care medicine for more than 15 years. (stanford.edu)
  • The University of Maryland Interstitial Lung Disease Program includes the ILD Clinic, directed by Drs. Jeffrey Hasday and E. James Britt , and Dr. Jeffrey Galvin , a world-renowned expert in interstitial lung diseases, rheumatologists with special expertise in lung diseases, and dedicated pulmonary pathologists. (umms.org)
  • The ILD takes an aggressive approach to arresting and reversing interstitial lung diseases based on close patient monitoring and frequent medication adjustment. (umms.org)
  • Not All Interstitial Lung Abnormalities Represent Disease Dr Aaron Holley discusses how to identify which ILAs are important and when they should be treated. (medscape.com)
  • Probiotic agent Saccharomyces boulardii reduces the incidence of lung injury in acute necrotizing pancreatitis induced rats. (harvard.edu)
  • reported that Semen Cassiae may reduce hepatic injury in rats [ 12 ]. (biomedcentral.com)
  • Nuclear factor-kappa B (NF-κB) p65 translocation was assessed by Western blot.Results:The rats that underwent OALT exhibited severe pulmonary damage with a high wet-to-dry ratio, low partial pressure of oxygen, and low precursor surfactant protein C levels, which corresponded to the significant elevation of pro-inflammatory cytokines, β-hexosaminidase, and tryptase levels in serum and lung tissues. (elsevier.com)
  • 0.0001) and decreased pulmonary edema and lung injury in LPS-induced lung injury in rats. (birmingham.ac.uk)
  • A new experimental model of acid- and endotoxin-induced acute lung injury in rats. (ac.ir)
  • Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. (jci.org)
  • Within 20 min after intraperitoneal injection of Salmonella enteritidis endotoxin in rats, blood platelet-activating factor (PAF) increased from 4.3 +/- 1.3 to 13.7 +/- 2.0 ng/ml (P less than 0.01) and lung PAF from 32.3 +/- 4.9 to 312.3 +/- 19.6 ng (P less than 0.01), but not lung lavage PAF. (jci.org)
  • Both CV 3988 and SRI 63-441 blocked the increased extravascular accumulation of 125I-albumin and water in perfused lungs isolated from endotoxin-treated rats. (jci.org)
  • Chest radiographs were independently assessed by two observers for the presence or absence of acute respiratory distress syndrome. (medscape.com)
  • Thirty-one (21%) had acute respiratory distress syndrome (17 mild acute respiratory distress syndrome [12%], 9 moderate acute respiratory distress syndrome [12%], and 5 severe acute respiratory distress syndrome) within the first 72 hours following admission. (medscape.com)
  • Extravascular lung water index had a moderate sensitivity of 65% and specificity of 77% for the prediction of acute respiratory distress syndrome. (medscape.com)
  • The prevalence of lung injury is relatively low in acute liver failure, where 21% fulfilled acute respiratory distress syndrome criteria. (medscape.com)
  • Overall presence of acute respiratory distress syndrome appeared to have a limited impact on outcome. (medscape.com)
  • These data support the proposal that inosine might represent a useful adjunct in the therapy of acute respiratory distress syndrome. (nih.gov)
  • She had an acute onset of fever, cough, muscle pain and progressive dyspnea leading to acute respiratory distress syndrome. (biomedcentral.com)
  • Acute lung injury and acute respiratory distress syndrome after pulmonary resection. (duke.edu)
  • Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and inability to clear pulmonary edema. (birmingham.ac.uk)
  • Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome. (cdc.gov)
  • 1. Acute lung injury (ALI) or acute respiratory distress syndrome is a serious clinical problem with high mortality. (elsevier.com)
  • Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE). (rochester.edu)
  • Acute respiratory distress in adults. (ac.ir)
  • The main objective is to determine the short-term effect of prone positioning in infants with infection-associated severe acute respiratory distress syndrome. (centerwatch.com)
  • Treatment for severe acute respiratory distress syndrome from COVID-19. (ucsf.edu)
  • Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. (ucsf.edu)
  • Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. (ucsf.edu)
  • Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16. (biovendor.com)
  • Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study. (cell.com)
  • Parzibut G , Henket M , Moermans C , Struman I , Louis E , Malaise M , Louis R , Misset B , Njock MS , Guiot J . A Blood Exosomal miRNA Signature in Acute Respiratory Distress Syndrome. (wjgnet.com)
  • Guo W , Wang Z , Wang S , Liao X , Qin T . Transcriptome sequencing reveals differential expression of circRNAs in sepsis induced acute respiratory distress syndrome. (wjgnet.com)
  • 2] Confalonieri M, Salton F, Fabiano F. Acute respiratory distress syndrome. (signavitae.com)
  • Acute respiratory distress syndrome: the Berlin Definition. (signavitae.com)
  • 4] Matthay MA, McAuley DF, Ware LB. Clinical trials in acute respiratory distress syndrome: challenges and opportunities. (signavitae.com)
  • Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research. (signavitae.com)
  • Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design. (signavitae.com)
  • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. (medscape.com)
  • Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. (medscape.com)
  • Secondarily, we examined whether the attenuation of LPS-induced physiologic lung injury after administration of S1P was, at least in part, caused by an alteration in local and/or systemic inflammatory cytokine expression. (elsevier.com)
  • This network of PICU researchers identifies optimal supportive, preventive and therapeutic strategies for acute lung injury, sepsis, multi-organ failure, and life-threatening pulmonary or systemic inflammatory syndromes that affect critically ill infants and children. (rochester.edu)
  • Preclinical studies suggest that TD-0903 has a very high lung:plasma ratio and rapid metabolic clearance resulting in low systemic exposure, compatible with its lung selectivity. (cliniexpert.com)
  • Systemic inflammatory markers did not correlate with lung injury associated with MV. (elsevier.com)
  • Alterations in the mechanics of the chest wall: severe kyphoscoliosis, obesity, flail injury with multiple rib fractures, paralysis of the thoracic muscle and diaphragm, immobility of the chest wall, as in progressive systemic sclerosis. (yahoo.com)
  • Approaches include measurements of systemic and pulmonary vascular pressures, vascular ring reactivity, lung resistance, and compliance determinations, measurement of reactive oxygen and nitrogen species in cells and tissues using electron spin resonance spectroscopy, analysis of signaling pathways, gene and protein expression, to name a few. (emory.edu)
  • We conclude that PAF is produced in the lung during endotoxemia and may be an important mediator of the systemic and pulmonary hemodynamic changes as well as the acute lung vascular injury after endotoxemia. (jci.org)
  • His clinical interests include acute lung injury. (hopkinsmedicine.org)
  • These effects might progress over the next 24 to 72 hours to include acute lung injury, cardiac arrest, and death (1-4). (cdc.gov)
  • A recent study showed that soluble epoxide hydrolase (sEH) plays a prevailing role in the pathogenesis of acute lung injury (ALI) [ 4 ]. (biomedcentral.com)
  • Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI). (balkanmedicaljournal.org)
  • Broadly speaking, our laboratory studies pulmonary host defense and molecular pathogenesis of acute lung injury. (upmc.edu)
  • It is characterized by the acute onset of hypoxemia with radiographic infiltrates consistent with pulmonary edema, without elevations in the pulmonary capillary wedge pressure. (duke.edu)
  • The physiologic findings include acute hypoxemia and decreased pulmonary compliance despite normal cardiac function. (elitelearning.com)
  • It may be indicated in anticipation of imminent respiratory failure, acute respiratory failure, acute hypoxemia, or prophylactically. (wikipedia.org)
  • Taken together, multiple changes occurring in the lungs contribute to postoperative hypoxemia rather than atelectasis alone. (scielo.br)
  • VNS is currently being studied to modulate pro-inflammatory cytokines patterns and concentrations in a variety of acute and progressive inflammatory conditions, ranging from septic shock and asthma to stroke, rheumatoid arthritis and Inflammatory Bowel Disease. (clinicaltrials.gov)
  • 5. Reiss LK, Uhlig U, Uhlig S. Models and mechanisms of acute lung injury caused by direct insults. (ac.ir)
  • however, experimental models investigating the mechanisms of epithelial injury are lacking. (springeropen.com)
  • While the complex actions of MSCs are not yet fully understood, they appear to attenuate lung injury via three broad mechanisms. (bmj.com)
  • We are interested in probing host-pathogen interactions to examine mechanisms of host protection following pathogen-triggered injury from products of extracellular gram-negative pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae. (upmc.edu)
  • Dr. E. James Britt , a dedicated clinical pulmonologist, is studying mechanisms of rejection, and Dorothy Eddington, the transplant coordinator, round out the core faculty of the lung transplant program. (umms.org)
  • Modulation of pulmonary defense mechanisms against viral and bacterial infections by acute exposures to nitrogen dioxide / George J. Jakab. (who.int)
  • Influenza A (H1N1): the first hit for transfusion-related acute lung injury? (biomedcentral.com)
  • Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. (biomedcentral.com)
  • In individuals with sickle cell disease, clinical manifestations of delayed hemolytic transfusion reactions (DHTRs) usually appear 5-15 days after the triggering transfusion, and include hemoglobinuria, jaundice, and pallor due to acute hemolysis. (medscape.com)
  • Continuous monitoring of vital signs during general anesthesia may prevent acute circulatory (volume) overload, but it may not detect early signs of other reactions (eg, acute hemolytic transfusion reactions). (medscape.com)
  • Perioperative transfusion-related acute lung injury: The Canadian Blood Services experience. (nataonline.com)
  • His clinical interests include cellular therapies such as hematopoietic stem cell transplantation, the diagnosis and treatment of autoimmune cytopenias, and transfusion complications related to HLA alloimmunization such as transfusion-related acute lung injury and refractoriness to platelet transfusion. (massgeneral.org)
  • REDS-II approached both infectious and noninfectious problems, such as transfusion-related acute lung injury, that could affect the U.S. and international blood supply. (nih.gov)
  • A consensus redefinition of transfusion-related acute lung injury. (medscape.com)
  • Semple JW, Rebetz J, Kapur R. Transfusion-associated circulatory overload and transfusion-related acute lung injury. (medscape.com)
  • 2006) Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. (taconic.com)
  • Histone Deacetylase 7 in Murine Gram-Negative Acute Lung Injury. (duke.edu)
  • In this study, we investigated whether these purines can impact vascular injury in more clinically-relevant E.coli (non-sterile LPS) murine ALI model. (elsevier.com)
  • Unlike cigarette smoke exposure, LPS exposure does not suppress endogenous LTA 4 H AP activity, and therefore, active LTA 4 H AP clears PGP after exposure to LPS in murine lung 5 . (nature.com)
  • Using preclinical models of acute lung injury (ALI), we assessed the gene and protein expression of type 2 deiodinase (DIO2), a key driver for synthesis of biologically active triiodothyronine, and addressed potential association of DIO2 genetic variants with ALI in a multiethnic cohort.DIO2geneandprotein expression levels in murine lung were validated by microarrays and immunoblotting. (arizona.edu)
  • Further, permeability of murine isolated perfused lungs was determined following exposition to sphingosine-1-phosphate and pneumolysin. (edu.au)
  • We utilize a repertoire of relevant murine models of injury, molecular genetic approaches, in vitro biochemical assays, and human bio-samples to examine innate host defenses of the lung. (upmc.edu)
  • Lung Innate Lymphoid Cell Composition is Altered in Primary Graft Dysfunction. (upenn.edu)
  • 7,11 In response to infection, neutrophils accumulate (sequester) in the capillary beds prior to emigration into the lung proper. (elitelearning.com)
  • Our results showed that an oral administration of the extract 90 min before HCl instillation reduced the infiltration of neutrophils in the lungs in a dose‑dependent manner. (phcogres.com)
  • 2009). Therefore, inhibiting the accumulation of neutrophils in the lung may mitigate ECC-associated ALI (Zhou et al. (docksci.com)
  • 6 It has been reported that reactive oxygen species generated from neutrophils can induce lung injury and fibrosis. (bmj.com)
  • Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils. (genscript.com)
  • Title: Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury. (genscript.com)
  • The diagnosis is based fundamentally on the integration of clinical, radiological and gasometry elements, once the rest of the possible causes of acute lung injury have been ruled out. (who.int)
  • As disclosed initially at Theravance Biopharma'sDecember 2018 Research and Development Day, the Company indicated the initial clinical application of TD-0903 would be to explore its utility in preventing/delaying graft rejection among individuals receiving lung transplantation. (cliniexpert.com)
  • Clinical profile of gas leak victims in acute phase after Bhopal episode. (cdc.gov)
  • Multiple basic science and translational/clinical studies in progress, ranging from enzyme kinetic studies of how inflammatory proteases released after injury effect the bodies ability to stop bleeding, to both therapeutic and diagnostic clinical trials. (unmc.edu)
  • In 2021 the American Thoracic Society awarded her the Edward Livingston Trudeau Medal, given by the society to those who have made "lifelong contributions to the prevention, diagnosis, and treatment of lung disease through leadership in research, education, or clinical care. (uvm.edu)
  • includes background demographic and clinical information of the acute episode of COVID-19. (who.int)
  • We observed early acute lung injury (ALI) after a switch from veno-arterial extracorporeal life support (VA-ECLS) to long-term mechanical circulatory support (MCS). (unboundmedicine.com)
  • discussion 549-50 JF - European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery JO - Eur J Cardiothorac Surg VL - 44 IS - 3 N2 - OBJECTIVES: We observed early acute lung injury (ALI) after a switch from veno-arterial extracorporeal life support (VA-ECLS) to long-term mechanical circulatory support (MCS). (unboundmedicine.com)
  • Is there a role of TNFR1 in acute lung injury cases associated with extracorporeal circulation? (docksci.com)
  • Ferret acute lung injury model induced by repeated nebulized lipopolysaccharide administration. (ncsu.edu)
  • S1P has been demonstrated to protect against the formation of lipopolysaccharide (LPS)-induced lung edema when administered concomitantly with LPS. (elsevier.com)
  • Snelgrove reported that lipopolysaccharide (LPS) exposure causes bioproduction of PGP and acute lung injury 5 . (nature.com)
  • 1. Qing R, Huang Z, Tang Y, Xiang Q, Yang F. Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway. (ac.ir)
  • 2. Qian L, Zhao Y, Guo L, Li S, Wu X. Activating transcription factor 3 (ATF3) protects against lipopolysaccharide-induced acute lung injury via inhibiting the expression of TL1A. (ac.ir)
  • Yang S , Liu F , Wang D . Long noncoding RNA Kcnq1ot1 prompts lipopolysaccharide-induced acute lung injury by microRNA-7a-5p/Rtn3 axis. (wjgnet.com)
  • Li J , Zeng X , Wang W . miR-122-5p downregulation attenuates lipopolysaccharide-induced acute lung injury by targeting IL1RN. (wjgnet.com)
  • Our key finding is that the loss of this essential protein improves survival rate and it can intensely ameliorate endotoxin-induced lung injury through attenuated proinflammatory cytokine release, down-regulation of redox sensitive cellular pathways such as MAPKs, Akt, and NF-kappaB and reducing the production of ROS. (semmelweis.hu)
  • Associations between these polymorphisms and acute lung injury, as well as serum cytokine levels, were analyzed. (medscitechnol.com)
  • By its mechanism, TD-0903 has the potential to block release of cytokines and chemokines that may be associated with acute lung injury and the initiation of a cytokine storm syndrome. (cliniexpert.com)
  • Coronavirus disease-2019 (COVID-19) is an acute viral syndrome caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has resulted in a global pandemic. (thieme-connect.de)
  • With advances in interventional cardiology techniques, technologies, and pharmaceutical therapies, all-cause mortality has decreased during the acute phase of AMI over the past few decades ( Anderson and Morrow, 2017 ). (frontiersin.org)
  • Acute respiratory infections (ARI) have received far less attention in humanitarian relief and preparedness programmes despite recent evidence suggesting high excess morbidity and mortality and case fatality rates due to ARI occur during such events. (who.int)
  • We demonstrated that impaired mPT due to the lack of CypD reduces the severity of endotoxemia-induced lung injury suggesting that CypD specific inhibitors might have a great therapeutic potential in sepsis-induced organ failure. (semmelweis.hu)
  • Following a lung X-ray to confirm the diagnosis, the appropriate treatment is undertaken, depending on the severity of the condition. (sportsinjuryclinic.net)
  • Course of study required to educate a legally qualified and licensed practitioner of medicine, concerned with maintaining or restoring human health through the study, diagnosis and treatment of disease and injury, through the science of medicine and the applied practice of that science. (who.int)
  • It is also indicated to protect the uninvolved lung in the setting of pulmonary hemorrhage or infection, during one-lung lavage, or in the setting of a bronchopleural fistula. (medscape.com)
  • Dynamics of the viral replication, antibody response, and macrophage activation during acute SARS-CoV infection. (jci.org)
  • New trials are underway to test losartan as treatment for COVID-19, based on experimental and observational data suggesting that viral infection impairs ACE2 activity as a mediator of acute lung injury and possibly subsequent myocardial injury. (medpagetoday.com)
  • Pregnant women are at high risk of severe acute respiratory infection if infected with the influenza A (H1N1) virus. (scielo.org.za)
  • Cholera is an acute diarrhoeal infection caused by ingestion of food or water contaminated with the bacterium Vibrio cholerae. (who.int)
  • Dr Holley reviews whether magnesium is beneficial or harmful when treating acute exacerbations of COPD in an emergency setting. (medscape.com)
  • Her National Institutes of Health (NIH) supported research focused on biomarkers in acute lung injury. (uvm.edu)
  • Biomarkers in lung cancer screening: the importance of study design. (who.int)
  • We tested the effect of PAF receptor antagonists, CV 3988 and SRI 63-441, on endotoxin-induced hemodynamic changes and lung vascular injury. (jci.org)
  • Background:Acute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. (elsevier.com)
  • Postreperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation. (upenn.edu)
  • The University of Maryland Medical Center's Lung Transplantation Program is nationally preeminent, with a tradition of excellence dating back to 1992 when it performed the first single lung transplant in Maryland. (umms.org)
  • PMN emigration is directed by the endothelial cells and is comprised of adhesive events and squeezing of the PMNs between endothelial cells (diapedesis) to enter the lung. (elitelearning.com)
  • Such sequestration could result in ALI if a second event activates these adherent granulocytes and causes a focused release of the neutrophil microbicidal arsenal (defense against bacteria) into the pulmonary endothelial cells to which they adhere, resulting in endothelial damage and capillary leak of blood and plasma into the lung. (elitelearning.com)
  • Lu Z , Feng H , Shen X , He R , Meng H , Lin W , Geng Q . MiR-122-5p protects against acute lung injury via regulation of DUSP4/ERK signaling in pulmonary microvascular endothelial cells. (wjgnet.com)
  • Severe malaria can trigger acute lung injury characterized by pulmonary edema resulting from increased endothelial permeability. (jhu.edu)
  • CIRP induces lung ER stress and downstream responses to cause sepsis-associated ALI and this suggests CIRP directly induces ER stress via TLR4 activation. (semanticscholar.org)
  • The profibrotic cytokines PDGF and TGF-β1 were increased in lung fluid samples 1 week after peak expression of IL-1β. (jci.org)
  • The ratio of circulating concentrations of IL-10/IL-6 was associated with IL-6 genotypes and incidence of acute lung injury as well. (medscitechnol.com)
  • INTRODUCTION: There are many controversies in the existing epidemiological studies regarding the incidence and outcomes in acute lung injury. (usp.br)
  • Mechanical ventilation helps move air into and out of the lungs, with the main goal of helping the delivery of oxygen and removal of carbon dioxide. (wikipedia.org)
  • Mechanical ventilation is used for many reasons, including to protect the airway due to mechanical or neurologic cause, to ensure adequate oxygenation, or to remove excess carbon dioxide from the lungs. (wikipedia.org)
  • The two main types of mechanical ventilation include positive pressure ventilation where air is pushed into the lungs through the airways, and negative pressure ventilation where air is pulled into the lungs. (wikipedia.org)
  • The Greek physician Galen may have been the first to describe mechanical ventilation: "If you take a dead animal and blow air through its larynx [through a reed], you will fill its bronchi and watch its lungs attain the greatest distention. (wikipedia.org)
  • Low flow nasal cannula, high flow nasal cannula, non-invasive positive-pressure ventilation (NIPPV) (CPAP, specifically), and ultimately endotracheal intubation with mechanical ventilation at lung-protective tidal volumes (6-8mL/kg of ideal body weight) is the general progression of measures taken. (medscape.com)
  • Results suggested that treatment with NOB dramatically attenuated lung histopathological changes, wet-to-dry (W/D) ratio, myeloperoxidase (MPO) activity, the numbers of inflammatory cells, and TNF-α, IL-6, and NO in BALF induced by LPS. (greenmedinfo.com)
  • Silymarin ameliorated the histopathological lung injury with further up-regulation of Nrf-2 and HO-1 mRNA and decreased the inflammatory and fibrotic parameters together with up-regulation of the anti-apoptotic and the proliferation parameters. (ac.ir)
  • Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period. (ncsu.edu)
  • In the current study, we sought to determine the effectiveness of S1P to attenuate lung injury in a translationally relevant canine model of ALI when administered as rescue therapy. (elsevier.com)
  • Hypothesis 1B: Oral Administration or Nasal Feeding of Huzhangxiefei Decoction will attenuate sepsis-induced lung injury as assessed by the respiratory rate and oxygenation index . (centerwatch.com)
  • Table 1: Radiologic patterns of lung disease associated with occupational exposures on chest radiograph and chest CT. (cdc.gov)
  • Experts remain perplexed about what is causing the nationwide outbreak of mysterious vaping-related lung disease that has affected hundreds and killed at least six people. (scientificamerican.com)
  • The beneficial effect of N -acetyl- l -cysteine on bleomycin induced lung injury may be explained in part by the prevention of neutrophil recruitment in the inflammatory stage of the disease. (bmj.com)
  • allergies and lung disease. (hopkinsmedicine.org)
  • Cholera is an extremely virulent disease that can cause severe acute watery diarrhoea with severe dehydration. (who.int)
  • Our results show that MTX reduces weight of the lung, infiltration of neutrophil and lymphocyte and bronchoalveolar protein concentration. (ersjournals.com)
  • Acute aerosol exposure of 4,4'-diphenylmethane diisocyanate elicits eosinophilic infiltration into Brown Norway rat airways. (cdc.gov)
  • A number of adhesion molecules are involved in the process of neutrophil infiltration into the lung. (bmj.com)
  • The scientists reasoned that since in acute lung injury most of the damage occurs to the cells lining the blood vessels, addition of cells that can protect, or even regenerate these cells may be therapeutically useful. (cellmedicine.com)
  • It occurs when there is a build-up of air in the space between the lungs and the rib cage. (sportsinjuryclinic.net)
  • As the name suggests, occurs as a result of a traumatic injury, allowing air from outside the body into this space. (sportsinjuryclinic.net)
  • In addition to the acute necrotic damage that occurs in the neurons initially, reperfusion injury and secondary neuronal damage continue for 6 to 72 hours after the initial insult. (stanford.edu)
  • Tsunami lung occurs when people being swept by tsunami waves inhale salt-water contaminated with mud and bacteria. (who.int)
  • Lack of cyclophilin D protects against the development of acute lung injury in endotoxemia. (semmelweis.hu)
  • Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury. (upmc.edu)
  • Sun Q , Xia Y, Qin H, Zhang W, Wang J, Ning Y, Dong Y. MEF2 intervened LPS-induced acute lung injury by binding to KLF2 promoter and modulating macrophage phenotype. (wjgnet.com)
  • In addition, the vitamin D receptor (VDR), which mediates the activities of 1,25(OH)2D3, protects against sepsis-induced lung injury by inhibiting the angiopoietin-2-TEK receptor tyrosine kinase-myosin light-chain kinase pathway ( 10 ). (spandidos-publications.com)
  • VNS has been studied in animal models of acute septic shock, consistently demonstrating life-saving potential. (clinicaltrials.gov)
  • The development of heart failure (HF) remains a common complication following an acute myocardial infarction (AMI), and is associated with substantial adverse outcomes. (frontiersin.org)
  • Acute myocardial infarction (AMI) is characterized by myocardial necrosis resulting from exposure to prolonged ischemia after occlusion of a coronary artery ( Anderson and Morrow, 2017 ). (frontiersin.org)
  • Various forms of thrombosis, from thrombotic microangiopathy to large-vessel thrombosis in the venous system (deep vein thrombosis, splanchnic vein thrombosis, pulmonary embolism) or the arterial system (including acute myocardial infarction, ischemic stroke, and acute limb ischemia), have been described. (thieme-connect.de)
  • The objectives of this study were to investigate whether IL-6 -572C/G, IL-10 -1082A/G, and TNF-alpha -308G/A were associated with acute lung injury after cardiac surgery with cardiopulmonary bypass. (medscitechnol.com)
  • Acute lung injury after cardiac surgery with cardiopulmonary bypass was associated with IL-6 -572C/G polymorphism, but not IL-10 -1082A/G or TNF-alpha -308G/A. This functional polymorphism was further confirmed by multivariate analyses. (medscitechnol.com)
  • The IL-6 -572 polymorphism was associated with acute lung injury after cardiac surgery with cardiopulmonary bypass. (medscitechnol.com)
  • In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion. (biovendor.com)
  • What are the phases of acute renal failure? (flashcardmachine.com)
  • Diseases commonly treated in the MICU include sepsis, acute lung injury, oncologic emergencies, respiratory failure, and liver and renal failure. (umms.org)
  • Aspiration is a common cause of acute lung injury (ALI), which lacks an effective treatment. (ac.ir)
  • The lungs were ventilated with 100% oxygen and a tidal volume of 600 ml with peak inspiratory pressures (PIP) of 18-20 cm H 2 O. Postintubation arterial blood gas assessment showed a Pao 2 of 427 mmHg, a Paco 2 of 38 mmHg, and a pH of 7.41. (asahq.org)
  • Male Sprague-Dawley rat lungs were injured by intratracheal instillation of LPS. (biomedcentral.com)
  • LL-37 is a peptide secreted by MSCs which has direct antimicrobial properties and has previously been shown to increase bacterial clearance in an Escherichia coli model of lung injury after the intratracheal administration of MSCs. (bmj.com)
  • We used adenoviral gene transfer to transiently overexpress IL-1β in rat lungs after intratracheal administration. (jci.org)