Limb Salvage: An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Amputation: The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)Lower Extremity: The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.Leg: The inferior part of the lower extremity between the KNEE and the ANKLE.Extremities: The farthest or outermost projections of the body, such as the HAND and FOOT.Popliteal Artery: The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.Embolectomy: Surgical removal of an obstructing clot or foreign material which has been transported from a distant vessel by the bloodstream. Removal of a clot at its original site is called THROMBECTOMY.Thrombectomy: Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY.Vascular Patency: The degree to which BLOOD VESSELS are not blocked or obstructed.Femoral Artery: The main artery of the thigh, a continuation of the external iliac artery.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.New England: The geographic area of New England in general and when the specific state or states are not indicated. States usually included in this region are Maine, New Hampshire, Vermont, Massachusetts, Connecticut, and Rhode Island.Tibial Arteries: The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.Iliac Artery: Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.Acute Disease: Disease having a short and relatively severe course.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Graft Occlusion, Vascular: Obstruction of flow in biological or prosthetic vascular grafts.Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Limb Buds: Distinct regions of mesenchymal outgrowth at both flanks of an embryo during the SOMITE period. Limb buds, covered by ECTODERM, give rise to forelimb, hindlimb, and eventual functional limb structures. Limb bud cultures are used to study CELL DIFFERENTIATION; ORGANOGENESIS; and MORPHOGENESIS.Peripheral Vascular Diseases: Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Hindlimb: Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)Thrombolytic Therapy: Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.Veins: The vessels carrying blood away from the capillary beds.Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.Arteriosclerosis Obliterans: Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.Angioplasty, Balloon: Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.Gangrene: Death and putrefaction of tissue usually due to a loss of blood supply.Inguinal Canal: The tunnel in the lower anterior ABDOMINAL WALL through which the SPERMATIC CORD, in the male; ROUND LIGAMENT, in the female; nerves; and vessels pass. Its internal end is at the deep inguinal ring and its external end is at the superficial inguinal ring.Peripheral Arterial Disease: Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.Polytetrafluoroethylene: Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.Critical Illness: A disease or state in which death is possible or imminent.Atherectomy: Endovascular procedure in which atheromatous plaque is excised by a cutting or rotating catheter. It differs from balloon and laser angioplasty procedures which enlarge vessels by dilation but frequently do not remove much plaque. If the plaque is removed by surgical excision under general anesthesia rather than by an endovascular procedure through a catheter, it is called ENDARTERECTOMY.Angiography: Radiography of blood vessels after injection of a contrast medium.Life Tables: Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Saphenous Vein: The vein which drains the foot and leg.Vascular Grafting: Surgical insertion of BLOOD VESSEL PROSTHESES, or transplanted BLOOD VESSELS, or other biological material to repair injured or diseased blood vessels.Diabetic Foot: Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.Foot Ulcer: Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.Blood Gas Monitoring, Transcutaneous: The noninvasive measurement or determination of the partial pressure (tension) of oxygen and/or carbon dioxide locally in the capillaries of a tissue by the application to the skin of a special set of electrodes. These electrodes contain photoelectric sensors capable of picking up the specific wavelengths of radiation emitted by oxygenated versus reduced hemoglobin.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Thromboangiitis Obliterans: A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.Reperfusion Injury: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.Angioplasty: Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.Limb Deformities, Congenital: Congenital structural deformities of the upper and lower extremities collectively or unspecified.Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.Constriction, Pathologic: The condition of an anatomical structure's being constricted beyond normal dimensions.Reconstructive Surgical Procedures: Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.Endovascular Procedures: Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.Ultrasonography, Doppler, Duplex: Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Ankle Brachial Index: Comparison of the BLOOD PRESSURE between the BRACHIAL ARTERY and the POSTERIOR TIBIAL ARTERY. It is a predictor of PERIPHERAL ARTERIAL DISEASE.Arm: The superior part of the upper extremity between the SHOULDER and the ELBOW.Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)Phantom Limb: Perception of painful and nonpainful phantom sensations that occur following the complete or partial loss of a limb. The majority of individuals with an amputated extremity will experience the impression that the limb is still present, and in many cases, painful. (From Neurol Clin 1998 Nov;16(4):919-36; Brain 1998 Sep;121(Pt 9):1603-30)Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Neovascularization, Physiologic: The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Arteries: The vessels carrying blood away from the heart.Wound Healing: Restoration of integrity to traumatized tissue.Surgical Flaps: Tongues of skin and subcutaneous tissue, sometimes including muscle, cut away from the underlying parts but often still attached at one end. They retain their own microvasculature which is also transferred to the new site. They are often used in plastic surgery for filling a defect in a neighboring region.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Toes: Any one of five terminal digits of the vertebrate FOOT.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Recovery of Function: A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Axillary Artery: The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Reperfusion: Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.Ischemic Preconditioning: A technique in which tissue is rendered resistant to the deleterious effects of prolonged ISCHEMIA and REPERFUSION by prior exposure to brief, repeated periods of vascular occlusion. (Am J Physiol 1995 May;268(5 Pt 2):H2063-7, Abstract)Intermittent Pneumatic Compression Devices: Instruments that generate intermittent forces, uniformed or graduated, to facilitate the emptying of VEINS. These devices are used to reduce limb EDEMA and prevent venous THROMBOEMBOLISM, such as deep vein thrombosis in the legs.Aneurysm: Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Leg Injuries: General or unspecified injuries involving the leg.Arteriovenous Shunt, Surgical: Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)Femoral NeoplasmsMyocardial Reperfusion Injury: Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Collateral Circulation: Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Laser-Doppler Flowmetry: A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Chemotherapy, Cancer, Regional Perfusion: Neoplasm drug therapy involving an extracorporeal circuit with temporary exclusion of the tumor-bearing area from the general circulation during which high concentrations of the drug are perfused to the isolated part.Catheterization, Peripheral: Insertion of a catheter into a peripheral artery, vein, or airway for diagnostic or therapeutic purposes.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Diabetic Angiopathies: VASCULAR DISEASES that are associated with DIABETES MELLITUS.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Chondrosarcoma: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)Angiography, Digital Subtraction: A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.Groin: The external junctural region between the lower part of the abdomen and the thigh.Femoral Vein: The vein accompanying the femoral artery in the same sheath; it is a continuation of the popliteal vein and becomes the external iliac vein.Recurrence: The return of a sign, symptom, or disease after a remission.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Leg Bones: The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.Debridement: The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)Fibula: The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.Patient Selection: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.Endarterectomy: Surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.Tourniquets: Devices for the compression of a blood vessel by application around an extremity to control the circulation and prevent the flow of blood to or from the distal area. (From Dorland, 28th ed)Humerus: Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Forefoot, Human: The forepart of the foot including the metatarsals and the TOES.Warm Ischemia: A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.Arm Injuries: General or unspecified injuries involving the arm.Upper Extremity: The region of the upper limb in animals, extending from the deltoid region to the HAND, and including the ARM; AXILLA; and SHOULDER.Pelvic Bones: Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.Forelimb: A front limb of a quadruped. (The Random House College Dictionary, 1980)Ischemic Preconditioning, Myocardial: Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Tibial FracturesPopliteal Vein: The vein formed by the union of the anterior and posterior tibial veins; it courses through the popliteal space and becomes the femoral vein.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Embolism: Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Replantation: Restoration of an organ or other structure to its original site.Diabetes Complications: Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.Operative Blood Salvage: Recovery of blood lost from surgical procedures for reuse by the same patient in AUTOLOGOUS BLOOD TRANSFUSIONS. It is collected during (intraoperatively) or after completion of (postoperatively) the surgical procedures.Prostheses and Implants: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.Cold Ischemia: The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.Polyethylene Terephthalates: Polyester polymers formed from terephthalic acid or its esters and ethylene glycol. They can be formed into tapes, films or pulled into fibers that are pressed into meshes or woven into fabrics.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Ankle: The region of the lower limb between the FOOT and the LEG.Myocardial Reperfusion: Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.Spinal Cord Ischemia: Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.Regeneration: The physiological renewal, repair, or replacement of tissue.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Prosthesis-Related Infections: Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).Gerbillinae: A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.Artificial Limbs: Prosthetic replacements for arms, legs, and parts thereof.Free Tissue Flaps: A mass of tissue that has been cut away from its surrounding areas to be used in TISSUE TRANSPLANTATION.Fractures, Spontaneous: Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)Biological Dressings: Human or animal tissue used as temporary wound coverings.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Prosthesis Implantation: Surgical insertion of a prosthesis.Capillaries: The minute vessels that connect the arterioles and venules.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Heel: The back (or posterior) of the FOOT in PRIMATES, found behind the ANKLE and distal to the TOES.Walking: An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Electric Stimulation Therapy: Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Orthopedic Procedures: Procedures used to treat and correct deformities, diseases, and injuries to the MUSCULOSKELETAL SYSTEM, its articulations, and associated structures.Aorta, Abdominal: The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Databases as Topic: Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)Aortic Diseases: Pathological processes involving any part of the AORTA.Radiology, Interventional: Subspecialty of radiology that combines organ system radiography, catheter techniques and sectional imaging.Loop of Henle: The U-shaped portion of the renal tubule in the KIDNEY MEDULLA, consisting of a descending limb and an ascending limb. It is situated between the PROXIMAL KIDNEY TUBULE and the DISTAL KIDNEY TUBULE.Histiocytoma, Benign Fibrous: A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)Angiogenesis Inducing Agents: Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.Bone Transplantation: The grafting of bone from a donor site to a recipient site.Mice, Inbred C57BLAngioscopy: Endoscopic examination, therapy or surgery performed on the interior of blood vessels.Ischemic Postconditioning: The application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Brachial Artery: The continuation of the axillary artery; it branches into the radial and ulnar arteries.Vascular Access Devices: Devices to be inserted into veins or arteries for the purpose of carrying fluids into or from a peripheral or central vascular location. They may include component parts such as catheters, ports, reservoirs, and valves. They may be left in place temporarily for therapeutic or diagnostic purposes.Necrosis: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.Alloys: A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Microcirculation: The circulation of the BLOOD through the MICROVASCULAR NETWORK.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Length of Stay: The period of confinement of a patient to a hospital or other health facility.Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Ligation: Application of a ligature to tie a vessel or strangulate a part.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Hemostatic Techniques: Techniques for controlling bleeding.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Angiogenic Proteins: Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.Wounds, Nonpenetrating: Injuries caused by impact with a blunt object where there is no penetration of the skin.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Injections, Intra-Arterial: Delivery of drugs into an artery.
Acute limb ischaemia
Early detection and steps towards fixing the problem with limb-sparing techniques can salvage the limb. Compartment syndrome ... Renal ischemia (nephric ischemia) Mesenteric ischemia Cerebral ischemia Cardiac ischemia In order to treat acute limb ischaemia ... Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb. Acute limb ischaemia is caused by ... In treating acute limb ischaemia time is everything. In the worst cases acute limb ischaemia progresses to critical limb ...
Lack of blood flow to a limb results in acute limb ischemia. Reduced blood flow to the skin layers may result in mottling or ... Amputation is reserved for cases where limb salvage is not possible. If the patient continues to have a risk of further ... Clinical manifestations of acute limb ischemia (which can be summarized as the "six P's") include pain, pallor, pulseless, ... Brain ischemia is insufficient blood flow to the brain, and can be acute or chronic. Acute ischemic stroke is a neurologic ...
2009). "The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemia". Cytotherapy ... factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute ... "TNF receptor 2, not TNF receptor 1, enhances mesenchymal stem cell-mediated cardiac protection following acute ischemia". Shock ... Clinical trials for treatment of acute MI with Prochymal by Osiris Therapeutics are underway. Also, a clinical trial revealed ...
... but can be due to acute limb ischemia. The limited oxygen in the ischemic limb limits putrefaction and bacteria fail to survive ... Because of the high mortality associated with infected gangrene, an emergency salvage amputation, such as a guillotine ... Venous limb gangrene may be caused by heparin-induced thrombocytopenia and thrombosis (HITT). Severe mesenteric ischemia may ... In the case of gangrene due to critical limb ischemia, revascularization can be performed to treat the underlying peripheral ...
Remote ischemic conditioning
The procedure involves repeated, temporary cessation of blood flow to a limb to create ischemia (lack of oxygen and glucose) in ... and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial". The Lancet. 375 (9716): 727 ... Either the upper limb (arm) or the lower limb (leg) may be used; however, because it is easier and more comfortable, most ... "Transient limb ischemia induces remote ischemic preconditioning in vivo". Circulation. 106 (23): 2881-2883. doi:10.1161/01.cir. ...
... s are caused by ischemia or a lack of blood flow to the brain. There are several causes of ischemia, including ... The TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification is based on clinical symptoms as well as results of ... New research is being conducted in metabolic suppression, direct energy delivery, and selective drug delivery to help salvage ... "Hands-on therapy interventions for upper limb motor dysfunction following stroke". Cochrane Database of Systematic Reviews (6 ...
Vein graft disease
... and lower limb amputation. Venous failure represents the most common complication in free flap surgery(16) and venous ... post-harvest ischemia, oxidative stress, reperfusion injury and adaptive stress in the new post grafting environment. ... Endothelium can be destroyed or damaged intraoperatively through the acute physical stress of harvesting, storage, handling and ... thrombosis mediated early failure is frequent(17) and requires re-exploration and revision surgery for flap salvage. VGD and ...
... but rarely can cause lower back pain or lower limb ischemia Flank pain and tenderness Hypertension Haematuria Signs of ... 1997). "Kidney salvage in a case of ruptured renal artery aneurysm: case report and literature review". Cardiovasc Surg. 5 (1 ... New devices were recently developed to substitute the external ligature by expandable ring allowing use in acute ascending ...
Abdominal aneurysms are usually asymptomatic, but rarely can cause lower back pain or lower limb ischemia ... 1997). "Kidney salvage in a case of ruptured renal artery aneurysm: case report and literature review". Cardiovasc Surg. 5 (1 ... New devices were recently developed to substitute the external ligature by expandable ring allowing use in acute ascending ...
Ischemia. Main article: Ischemia. Ischemia, meaning insufficient blood flow to a tissue, can also result in hypoxia. This ... Acute. If oxygen delivery to cells is insufficient for the demand (hypoxia), electrons will be shifted to pyruvic acid in ... For this reason, symptoms are worse when a limb is used. Pain may also be felt as a result of increased hydrogen ions leading ... Hillman, Ken; Bishop, Gillian (2004). Clinical Intensive Care and Acute Medicine. Cambridge University Press. p. 685. ISBN 978- ...
Acute limb ischaemia - Wikipedia
Early detection and steps towards fixing the problem with limb-sparing techniques can salvage the limb. Compartment syndrome ... Renal ischemia (nephric ischemia) Mesenteric ischemia Cerebral ischemia Cardiac ischemia In order to treat acute limb ischaemia ... Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb. Acute limb ischaemia is caused by ... In treating acute limb ischaemia time is everything. In the worst cases acute limb ischaemia progresses to critical limb ...
Impact of Insurance Status on the Prognosis of Acute Lower Limb Ischemia
... of this study was to investigate if the insurance status of patients impacted the treatment options and prognosis in acute limb ... ischemia (ALI). A retrospective chart review was performed at a single university tertiary care center using ICD-9 codes for ... An Indication for Limb Salvage Surgery. Archives of Surgery, 111, 1263-1268. http://dx.doi.org/10.1001/archsurg. ... Distribution of Acute Lower Limb Ischemia. Limb ischemia and amputation are closely related to insurance costs, which in turn ...
Explaining the Discrepancy Between Lower Patency and Higher Limb Salvage Rates After Revascularization for Critical Limb...
Limb salvage rates that are consistently superior to patency rates for CLI patients have prompted some to question whether ... CKD and acute and long-term outcome of patients with peripheral artery disease and critical limb ischemia. Clin J Am Soc ... Long-term limb salvage and survival after endovascular and open revascularization for critical limb ischemia after adoption of ... One exception to this has been in the management of critical limb ischemia (CLI). In patients treated for CLI, limb salvage ...
VEGF Gene Transfer for Critical Limb Ischemia
Computed tomography angiography evaluation of acute limb ischemia.. Acute limb ischemia (ALI), a subclass of critical limb ... Limb Salvage. An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening ... Emergency Department Utilization after Lower Extremity Bypass for Critical Limb Ischemia.. Patients with critical limb ischemia ... Limb buds, covered by ECTODERM, give rise to forelimb, hindlimb, and eventual functional limb structures. Limb bud cultures are ...
San Diego Wound Care & Hyperbaric Oxygen Center - Tri-City Medical Center - Oceanside, CA
European Society for Vascular Surgery | News
Limb Salvage In Patients With Acute Ischemia Due To Thrombosed Popliteal Artery Aneurysm. ... Mid-Term Limb Salvage Following Plain Balloon Angioplasty For Severe Limb Ischaemia Due To Infra-Popliteal Disease: A ... Colonic Ischemia As An Early Marker Of Acute Mesenteric Ischemia. Andreia Coelho. Portugal. ... Pedal Arch Patency Guarantees Wound Healing And Limb Salvage Of Transmetatarsal Amputation Following Limb Revascularization.. ...
Use of Near Infrared Spectroscopy to Asses Remote Ischemic Preconditioning in Skeletal Muscle
In patients presenting with acute myocardial infarction, remote IPC by repeated limb ischemia before hospital admission ... and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial," The Lancet, vol. 375, no. ... is a procedure where brief periods of ischemia in one tissue prior to sustained ischemia reduce ischemia-reperfusion injury in ... R. K. Kharbanda, U. M. Mortensen, P. A. White et al., "Transient limb ischemia induces remote ischemic preconditioning in vivo ...
Acute Lower Extremity Ischemia | Springer for Research & Development
Acute lower extremity ischemia is a medical emergency. Appropriate clinical history, physical exam, and diagnostic tests using ... However, in case of threatened limbs, limb salvage using both anticoagulation and revascularization is the treatment of choice. ... Critical limb ischemia Acute limb ischemia ALI Revascularization Thrombolysis Thrombectomy This is a preview of subscription ... Berridge DC, Kessel D, Robertson I. Surgery versus thrombolysis for acute limb ischaemia: initial management. Cochrane Database ...
Thrombolysis may increase risk of major complications compared with surgery for limb ischemia - Clinical Advisor
surgery as initial treatment in 1,283 patients with acute limb ischemia (Cochrane Database Syst Rev. 2009;:CD002784). There ... were no significant differences in limb salvage or mortality at 30 days, six months, or one year. However, thrombolysis was ... Thrombolysis may increase risk of major complications compared with surgery for limb ischemia Alan Ehrlich, MD ... Close more info about Thrombolysis may increase risk of major complications compared with surgery for limb ischemia ...
tiihakka - Terkko Navigator
Endovascular stent placement in femoro-popliteal arterial occlusive disease
However, stents may have a limited role in salvage of acute PTA failures or complications." The recent studies noted above ... A widely used clinical system is the Rutherfords classification of chronic limb ischemia 3 (Table 1). Noninvasive hemodynamic ... Patients presenting with critical limb ischemia have a significantly lower patency rate after PTA of FPAOD compared with ... and patients with limb-threatening ischemia (rest pain or tissue loss) should be considered for intervention. ...
Articles Added on September 29, 2012
We report on a child in whom limb salvage was achieved in spite of a clinical picture of irreversible ischemia with high ... decision to amputate or perform limb salvage of a mangled extremity based on scoring systems and grading of acute ischemic limb ... Limb salvage in a child with severely injured mangled lower extremity and ... ... What is known and Objective: Triptans are approved medications introduced for the acute treatment of migraine, classified as ...
Community Academic Profiles - Faculty & Researchers - Stanford Medicine
... underwent UET for acute limb ischemia between 2014-2018. Rutherford Acute Limb Ischemia Classification was R1 in 56.3%, R2a in ... Limb salvage at 30-days and 1-year was 93.8% and 87.5%, respectively. Ipsilateral reintervention was required in 12.5% of ... Delayed Fasciotomy is Associated with Higher Risk of Major Amputation in Patients with Acute Limb Ischemia. Annals of vascular ... Delayed Fasciotomy Is Associated with Higher Risk of Major Amputation in Patients with Acute Limb Ischemia ANNALS OF VASCULAR ...
Dr. Christopher White, MD - New Orleans, LA - Book Online - Interventional Cardiology & Cardiology | Healthgrades.com
... limb-salvage angioplasty, pharmacologic and mechanical thrombolysis for acute ischemia, and acute stroke intervention. His ... Chronic mesenteric ischemia: Diagnosis and management. Prog Cardiovasc Dis. 2011; 54:36-40., 2011 ... Stroke intervention catheter-based therapy for acute ischemic stroke. J Am Coll Cardiol. 2011; 58:101-116., 2011 ...
SPECTRANETICS CORP (SPNC) Stock Message Board - InvestorsHub
Critical limb ischaemia (CLI). · Acute thrombotic occlusions. · Chronic total occlusions. Recent studies in populations ... With a 95% limb salvage rate* among survivors, the new CLiRpath system gives your CLI patients with total occlusions not ... presenting with CLI have demonstrated excellent limb salvage rates in patients with significant co-morbidities and those ... The Excimer laser has been approved for use in treating: · Long, diffuse lower limb arterial disease. · ...
DiVA - Sökresultat
Methods: This was a single center study of consecutive patients with acute and non-acute limb ischemia between September 1, ... Occluded cold stored venous allograft can be successfully re-opened in most cases with a favorable effect on limb salvage. ... The aim was to evaluate early outcomes, secondary patency and limb salvage rates of thrombolysed cold stored venous allograft ... Limb salvage rates at 1, 6, and 12 months after thrombolysis in the venous allograft group were 83 +/- 7%, 72 8% and 63 +/- 9 ...
Comparison of Clinical outcomes of Infragenicular Angioplasty between diabetic and non-diabetic patients with Peripheral...
Infragenicular angioplasty could salvage most of limbs under amputation impendence. We aim in our study to detect the results ... Endovascular therapy as the primary approach for limb salvage in patients with critical limb ischemia: experience with 443 ... The acute outcome of tibioperoneal vessel angioplasty in 417 cases with claudication and critical limb ischemia. ... 21 patients with limb-threatening underwent surgical bypass for limbsalvage with success rate 76.2% (16/21) while in 19 ...
Ischemia - Wikipedia
Lack of blood flow to a limb results in acute limb ischemia. Reduced blood flow to the skin layers may result in mottling or ... Amputation is reserved for cases where limb salvage is not possible. If the patient continues to have a risk of further ... Clinical manifestations of acute limb ischemia (which can be summarized as the "six Ps") include pain, pallor, pulseless, ... Brain ischemia is insufficient blood flow to the brain, and can be acute or chronic. Acute ischemic stroke is a neurologic ...
Saving the limb in diabetic patients with ischemic foot lesions complicated by acute infection<...
keywords = "acute infection, critical limb ischemia, limb salvage",. author = "Giacomo Clerici and Ezio Faglia", ... Each of these 2 conditions may lead to major limb amputation, and the presence of both critical limb ischemia (CLI) and acute ... Each of these 2 conditions may lead to major limb amputation, and the presence of both critical limb ischemia (CLI) and acute ... Each of these 2 conditions may lead to major limb amputation, and the presence of both critical limb ischemia (CLI) and acute ...
New ESC/ESVS Guidelines for the Diagnosis and Treatment of Peripheral Arterial Diseases (PAD)
Acute limb ischaemia with neurological deficit mandates urgent revascularization.. Multisite artery disease. Multisite artery ... Early recognition of tissue loss and/or infection and referral to a vascular specialist is mandatory for limb salvage by a ... The task force propose to stratify the risk of patients with chronic limb-threatening ischaemia according to the severity of ... In acute embolic occlusion, open and endovascular surgery seem to have similar success rates. ...
Below-the-Knee Revascularization of Critical Limb Ischemia in Diabetic Patients | Cath Lab Digest
... and the results of revascularization in diabetic patients with critical limb ischemia. ... Cryptogenic Stroke and Acute Lower Limb Ischemia in a Patient With a Patent Foramen Ovale ... Angioplasty on the Limb Salvage and Recovery of Symptoms in Patients With Buergers Disease With Critical Limb Ischemia ... Worse limb prognosis for indirect versus direct endovascular revascularization only in patients with critical limb ischemia ...
DiVA - Søkeresultat
... critical limb ischaemia (group 2, 33 %) and acute limb ischaemia (group 3, 20 %). Technical success rate was 99.3%, ... Occluded cold stored venous allograft can be successfully re-opened in most cases with a favorable effect on limb salvage. ... Patients with chronic limb ischemia, 2) acute limb ischemia, and 3) occlusion of a previous vascular reconstruction. The ... Methods: This was a single center study of consecutive patients with acute and non-acute limb ischemia between September 1, ...
Below-the-Knee Revascularization of Critical Limb Ischemia in Diabetic Patients | Vascular Disease Management
Between the appearance of an ulcer and the amputation of the limb, there should be treatment that should be rational, regulated ... and economical as to avoid the loss of the limb. ... The best rate of limb salvage was achieved by revascularization ... 9-14 Manzi et al reported an initial experience with the pedal plantar loop technique with positive clinical results at acute ... Worse limb prognosis for indirect versus direct endovascular revascularization only in patients with critical limb ischemia ...
Limb salvage in critical ischaemia | Virtual Health Sciences Library
... had acute onset of ischaemia while 77% presented with chronic ischaemia. Thromboembolectomy salvaged 80% of the acute ischaemia ... Board Subjects: Extremities ,Surgery ,Salvage Therapy Citation: Aftab A. Khan ,Moiz Ud Din , Limb salvage in critical ischaemia ... Limb salvage in critical ischaemia Khan Aftab A.; Moiz Ud Din; Pak. J. Surg. 1989; 5 (4-Mar): 35-40 PJS-Pakistan Journal of ... limb salvage. Aggressive attempts towards limb salvage is recommended ...
Superior Mesenteric Arterial Embolism Associated with an Acute Limb Ischemia: A Case Report and Literature Review
As for the acute limb ischemia, it was treated by efficient anticoagulation allowing limb salvage. Conclusion: When treating a ... Embolic occlusion brings dramatic limb ischemia and is the most frequent cause of acute limb ischemia  while thrombotic ... including limb loss  . Embolic arterial occlusion is the etiology of acute limb ischemia in 15% of the patients, while ... Acute limb ischemia occurs from abrupt interruption of blood flow to an extremity because of either embolic or thrombotic ...
Peripheral Arterial Occlusive Disease Guidelines: SVS/ESVS/WFVS Guidelines on Chronic Limb-Threatening Ischemia, ESC/ESVS...
... should not be offered to improve limb salvage in patients with CLTI who have severe uncorrected ischemia (eg, WIfI ischemia ... Recommendations for management of acute limb ischemia are as follows:. * In the case of neurologic deficit, urgent ... Graz Critical Limb Ischemia Score: A Risk Score for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease. Medicine ( ... SVS/ESVS/WFVS Guidelines on Chronic Limb-Threatening Ischemia. Clinical guidelines on chronic limb-threatening ischemia were ...
Peripheral Artery Disease (PAD): St. Elizabeth's Med Center | Steward Family Hospital | Brighton MA
Conditions related to PAD include: acute limb isc... ... in which narrowed arteries reduce blood flow to the limbs, ... Catheter-based revascularization procedures for the treatment of acute limb ischemia, claudication, gangrene / limb salvage and ... Conditions related to PAD include: acute limb ischemia; claudication; gangrene / limb salvage; and ulcerative disease. ... Catheter-based embolectomy, thrombectomy, thrombolysis for the treatment of acute limb ischemia. A series of terms used to ...
Internet Scientific Publications
5. Jivegård L, Holm J, Scherstén T. Acute limb ischemia due to arterial embolism or thrombosis: influence of limb ischemia ... Thus, a minimally invasive alternative to open surgery is desirable, provided that the rate of limb salvage remains similar and ... The Risk of Morbidity and Mortality in Acute Limb Ischemia. The acute occlusion of a peripheral artery is a catastrophic event ... acute limb ischemia threatens both the patients limb and life. Traditionally, open surgical intervention has been the "gold ...
Inflammatory Response in Cardiovascular Surgery
Shear stress and endothelial cell retention in critical lower limb ischemia.- Arterial transplantantion for limb salvage.- ... Metalloproteinases in acute venous occlusion.- Idiopathic venous thromboembolism.- Inflammation, thrombogenesis, fibrinolysis ... Shear stress and endothelial cell retention in critical lower limb ischemia.- Arterial transplantantion for limb salvage.- ... Inflammatory markers and mortality in critical lower limb ischemia.- Artery wall remodeling and restenosis following vascular ...
Dubai Doctor Reviews : Dr. Anil Bansal Cardiologist Dubai
RevascularizationEndovascularChronic limb ischemiaCritical lower limb ischemiaEmbolismDistalExtremityPatency and limb salvageThrombolysis for acuteThromboticSuffering from critical limb ischemiaCoronarySurgicalPoplitealArterial ischemiaClinicalGraftLower limb ischaemiaUpper limbAorticTerms of limbBypass surgerySevere limb ischemiaDiseaseOptions for acute limbManagement of acute limbPatientInterventionsMorbidity and mortaPatients with acuteIschemic strokeEmbolectomyAbdominalBilateral lowerSecondary patencySurgeryUnderwentMortality
- These two factors, along with a few other facets that are unique to this complicated CLI cohort, help to explain the nature of the difference between the higher limb salvage rates and lower patency rates after revascularization. (vasculardiseasemanagement.com)
- Viable limbs can be managed with anticoagulation, followed by revascularization. (springer.com)
- However, in case of threatened limbs, limb salvage using both anticoagulation and revascularization is the treatment of choice. (springer.com)
- Despite surgical bypass is considered the gold standard due to better anatomical and clinical durability compared to other revascularization methods for critical lower limb ischemia (CLI), [ 1 - 3 ] percutaneous transluminal angioplasty (PTA) in peripheral arterial occlusive disease (PAOD) is a valuable way of treating CLI, and has similar outcomes to those of bypass surgery [ 4 , 5 ]. (omicsonline.org)
- Because nerves are extremely sensitive to hypoxia, limb paralysis or ischemic neuropathy may persist after revascularization and may be permanent. (wikipedia.org)
- Revascularization can be proposed for severe/disabling symptoms, bilateral stenosis or stenosis with ipsilateral arteriovenous fistula for dialysis or in patients planned for coronary artery bypass grafting (CABG) or those already operated on with ipsilateral internal mammary artery grafted to coronary arteries with evidence of myocardial ischemia. (pcronline.com)
- This is particular important in case of symptomatic multivessel chronic mesenteric ischemia (CMI) where any delay in revascularization should be avoided. (pcronline.com)
- Despite this, most studies published to date that analyze DF revascularization use it in the gradation of ischemia. (cathlabdigest.com)
- High-quality angiographic imaging of the lower limb (including the ankle and foot) should be performed in all patients with suspected CLTI who may be candidates for revascularization. (medscape.com)
- An integrated limb-based anatomic staging system (eg, Global Limb Anatomic Staging System [GLASS]) should be used to define the complexity of a preferred target artery path (TAP) and to aid in revascularization (EBR) in patients with CLTI. (medscape.com)
- Median time to revascularization was 5.5 (2-16) hours with all limbs salvaged. (biomedcentral.com)
- Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis. (academictree.org)
- He presented to the ED with left foot pain concerning for acute limb ischemia needing for prompt revascularization. (clinmedjournals.org)
- The cornerstone of limb salvage remains early revascularization combined with maximal optimal medical therapy and wound care. (clinmedjournals.org)
- mean age 71.5, range 44-85) underwent to emergent revascularization for upper limb ischemia due to thrombosis/embolization of SAA by means of brachial embolectomy and endovascular exclusion. (annaliitalianidichirurgia.it)
- ABSTRACT Objective: to evaluate the use of a bacterial cellulose biopolymer film and gel dressing in the treatment of patients with ischemic wounds submitted to lower limb revascularization. (bvsalud.org)
- We followed 24 patients after lower limb revascularization, divided into two groups: Experimental, treated with bacterial cellulose biopolymer film and gel, and Control, treated with essential fatty acids. (bvsalud.org)
- Conclusion: the bacterial cellulose biopolymer film associated with gel can be used as a dressing in the treatment of ischemic wounds of patients undergoing revascularization of the lower limbs. (bvsalud.org)
- GORE® PROPATEN® Vascular Graft, a leading prosthetic vascular graft for lower extremity revascularization, is specifically designed to reduce the risk of acute graft thrombotic failure. (goremedical.com)
- CONCLUSION: Duplex arterial mapping could be used to differentiate the subacute ischemia with removable thrombus and chronic arterial occlusions guiding for the best revascularization procedure accordingly. (minervamedica.it)
- Angioplasty of the tibioperoneal vessels has had limited application as a primary revascularization strategy for patients with critical limb ischemia (CLI), 1-4 with the rationale of its limitation focusing on the requirement for revascularization of inflow lesions and the doubtful success of emergency surgery. (ahajournals.org)
- Compared with males, females have marginally worse outcomes including limb salvage, morbidity, and mortality after lower extremity revascularization procedures. (onlinejacc.org)
- The principal research question is which treatment modality between open surgical, endovascular and conservative therapy is the most effective in terms of limb salvage, survival and reinte. (bioportfolio.com)
- Endovascular first strategy for critical limb ischemia is widely accepted, because of the increasing patency rates and minimal invasive character, especially in elderly patients. (bioportfolio.com)
- Study design: We conducted a literature review of endovascular and surgical approaches for treatment of diabetic foot and critical limb ischemia (CLI) in Pubmed from 2002 to 2018. (cathlabdigest.com)
- The cure rate is not the stated objective of the TASC when evaluating the efficacy of endovascular therapy in critical ischemia of the lower limb. (cathlabdigest.com)
- The left shunt was complicated with acute upper limb ischemia and treated with endovascular means. (jscimedcentral.com)
- Predictors of limb loss despite a patent endovascular-treated arterial segment. (buffalo.edu)
- Endovascular management of subacute lower extremity ischemia. (buffalo.edu)
- Does preferential use of endovascular interventions by vascular surgeons improve limb salvage, control of symptoms, and survival of patients with critical limb ischemia? (buffalo.edu)
- Her current and ongoing research interests involve long-term outcomes and prospective research in acute aortic dissection, investigating optimal radiological parameters for aortic (proximal and distal) remodeling, following aortic dissection and endovascular aneurysm repair, burden of aortic disease and outcomes research in women with cardiovascular risk/disease, etc. (uth.edu)
Chronic limb ischemia2
Critical lower limb ischemia2
- We hereby report a new case of AMI due to embolism of the SMA associated with lower limb acute ischemia. (scirp.org)
- The introduction of computed tomographic pulmonary angiography and its recent increasing availability has led to a significant rise in its use to help clinicians diagnose acute pulmonary embolism (PE. (unboundmedicine.com)
- Ischaemia of the arm is most often embolism of cardiac origin, but may also be due to damage to the subclavian artery or thoracic outlet syndrome. (high-kick.ru)
- The Authors report their experience in the management of acute lower limbs ischemia throught distal popliteal artery approach. (cnr.it)
- In the absence of facilities for emergency contrast angiography at the National Hospital at the time, decisions on surgical exploration and repair were entirely clinical, based on distal ischaemia, pulsatile bleeding, expanding haematoma, palpable thrill or bruit. (biomedcentral.com)
- The case aims to illustrate the feasibility of a retrograde ipsilateral transpedal approach when the commonly used contralateral femoral and ipsilateral anterograde femoral approaches are inaccessible for the treatment of distal lower limb ALI. (clinmedjournals.org)
- Acute procedural success was defined as dilatation of the inflow lesion when present and critical lesion (≤50% residual stenosis) and/or angiographic improvement in the distal collateral flow circumventing obstructed vessels by relief of a more proximal lesion(s). (ahajournals.org)
- Regardless of the treatment modality used, early diagnosis and rapid initiation of therapy are essential in order to salvage the ischemic extremity. (scirp.org)
- Emergency Department Utilization after Lower Extremity Bypass for Critical Limb Ischemia. (bioportfolio.com)
- Acute lower extremity ischemia is a medical emergency. (springer.com)
- Recommended standards for reports dealing with lower extremity ischemia: revised version. (springer.com)
- Aurshina A., Hingorani A. (2019) Acute Lower Extremity Ischemia. (springer.com)
- Paralysis is a very late sign of acute arterial ischemia and signals the death of nerves supplying the extremity. (wikipedia.org)
- Reduced blood flow to the skin layers may result in mottling or uneven, patchy discoloration of the skin Ischemia is a vascular disease involving an interruption in the arterial blood supply to a tissue, organ, or extremity that, if untreated, can lead to tissue death. (wikipedia.org)
- Clerici, G & Faglia, E 2014, ' Saving the limb in diabetic patients with ischemic foot lesions complicated by acute infection ', International Journal of Lower Extremity Wounds , vol. 13, no. 4, pp. 273-293. (elsevier.com)
- Grade wound extent, degree of ischemia, and infection severity with a lower-extremity threatened-limb classification staging system to guide clinical treatment in all patients with suspected CLTI. (medscape.com)
- A retrospective descriptive review of eighty one consecutive extremity vascular injuries in seventy patients during a seven month period was performed with regards to the cause of injury, types of presentations, ischaemia time, interventional procedures, complications and early outcome. (biomedcentral.com)
- Ability of lower-extremity injury severity scores to predict functional outcome after limb salvage. (east.org)
- This multi-center prospective study confirmed the inability of multiple scoring systems including the Mangled Extremity Severity Score, Limb Salvage Index, Predictive Salvage Index, and Hannover Fracture Scale-98 to accurately predict functional recovery after limb salvage following severe extremity trauma. (east.org)
- His clinical interests include management of aortic diseases and lower extremity circulatory disorders, including limb salvage. (stanfordhealthcare.org)
- On the extremity examination, both limbs appeared dusky, cold clammy on to touch, numbness reduced sensation over bilateral lower limb, poor capillary refill time crt less than 4 seconds, and SPO2 ranging 70-75% all toes. (m-jem.com)
- This study reports our experience with 10 patients who underwent the emergent construction of a femorofemoral bypass graft to salvage an acutely ischemic lower extremity following the insertion of a transfemoral intra-aortic balloon pump catheter. (elsevier.com)
- All patients had excellent resolution of the ischemia and salvage of the extremity. (elsevier.com)
- The use of femorofemoral bypass grafting is, therefore, recommended in patients with severe ipsilateral limb ischemia who are dependent on an intra-aortic balloon pump to prevent extremity tissue loss as well as the systemic metabolic manifestations of ongoing tissue ischemia and necrosis. (elsevier.com)
- Mangled extremity: to salvage or not to salvage? (bmj.com)
Patency and limb salvage3
- In an effort to better explain this very reproducible phenomenon, our analysis suggests that the difference between patency and limb salvage rates can be explained by a number of factors, the most important of which are the effects of reintervention and the severity of tissue loss present in the CLI population under study. (vasculardiseasemanagement.com)
- Primary, primary assisted and secondary patency and limb salvage were calculated using the Kaplan Meyer's life table method. (annaliitalianidichirurgia.it)
- We have recently reported the patency and limb salvage results of a large number of axillofemoral grafts. (elsevier.com)
Thrombolysis for acute2
Suffering from critical limb ischemia2
- This review summarises the mechanisms involved in the high ischaemic and bleeding risk of patients with chronic kidney disease CKD and the risk-benefit ratio of potent antiplatelet drugs during acute coronary syndrome. (kingsthrombosiscentre.org.uk)
- Does remote organ ischaemia trigger cardiac preconditioning during coronary artery surgery? (hindawi.com)
- Damage introduced by ischemia reperfusion injury (IR injury) is pivotal in diseases such as coronary heart disease (CHD) and stroke, causing substantial mortality and morbidity [ 1 , 2 ]. (mdpi.com)
- Previous proof-of-concept clinical studies using RIC before or during a major ischemic event have demonstrated improvements in surrogate markers of ischemia, such as increased myocardial salvage and reduced infarct size, in a variety of clinical scenarios including acute STEMI, elective PCI, and coronary artery bypass grafting surgery. (tt.se)
- Recent studies in populations presenting with CLI have demonstrated excellent limb salvage rates in patients with significant co-morbidities and those unsuitable for surgical treatment. (advfn.com)
- He has published on the surgical treatment of aortic aneurysms and the use of extracorporeal membrane oxygenation (ECMO) treatment of acute respiratory distress syndrome (ARDS). (stanford.edu)
- Without surgical revascularisation, complete acute ischaemia leads to extensive tissue necrosis within six hours. (high-kick.ru)
- The aortoiliac occlusive disease, known as Leriche syndrome, primarily merits an aortobifemoral bypass graft which is the standard surgical treatment of critical limb ischemia. (e-cvsi.org)
- Lower limb sensitivity and mobility were preserved, and the popliteal and tibial pulses were found. (scirp.org)
- Acute ischaemia (40%) was often from popliteal injuries. (biomedcentral.com)
- At the time of surgery, 38 of the 65 aneurysms (58%) were treated because symptomatic: 31 (82%) for limb ischemia (17 for acute ischemia, 14 for chronic ischemia), 6 (16%) for compression on the adjacent popliteal vein and 1 (2%) for rupture. (minervamedica.it)
- Forty-seven (72.3%) aneurysms were treated electively: 27 cases were asymptomatic and 20 others had chronic leg ischemia or compression on the popliteal vein. (minervamedica.it)
- Ischemic conditioning of the skeletal muscle on an upper or lower limb is a noninvasive, readily reproducible method for studying the effects on other remote organs and, therefore, might be easily translated into clinical practice. (hindawi.com)
- Clinical manifestations of acute limb ischemia (which can be summarized as the "six P's") include pain, pallor, pulseless, paresthesia, paralysis, and poikilothermia. (wikipedia.org)
- This review aims to analyze the different factors to be taken into account, based on the literature, in diabetic patients with critical limb ischemia, and how it will influence future clinical practice. (cathlabdigest.com)
- Clinical guidelines on chronic limb-threatening ischemia were released in June 2019 by the Society for Vascular Surgery (SVS), European Society for Vascular Surgery (ESVS), and World Federation of Vascular Societies (WFVS). (medscape.com)
- Current clinical practice guidelines suggest that clinicians take an individualized approach after carefully assessing the risk/benefit ratio for patients with SSPE and negative leg limb ultrasonography results. (unboundmedicine.com)
- With more than 10 years of performance, over 600,000 devices implanted, and over 2,000 limbs studied, the GORE® PROPATEN® Vascular Graft is a leading prosthetic bypass graft solution for proven clinical performance and low cumulative cost of care. (goremedical.com)
- The risk to life and limb can be high, and clinical signs initially can be subtle. (nmortho.com)
- Investigations to small molecule therapies such as antiplatelet drugs, anticoagulants and statins acting as prophylactics have not produced consistent benefit following an acute attack, whereas neuroprotective compounds such as albumin and minocycline are recently being explored in clinical trials [ 13 , 14 ]. (omicsonline.org)
- TORONTO, April 10, 2018 (GLOBE NEWSWIRE) -- CellAegis Devices Inc. ("CellAegis" or the "Company"), a commercial-stage medical device company advancing innovative, non-invasive, safe and cost-effective solutions for acute and chronic cardiovascular conditions, today announced enrollment of the first patients in a U.S. clinical trial ("SHIELD") of its autoRIC ® device. (tt.se)
- Clinical features of rejection can overlap with ischemia/reperfusion injury, allograft dysfunction, or ureteral obstruction and therefore other conditions need to be ruled out at the same time. (clinicaladvisor.com)
- Overall in the bypass procedures there was 88% immediate graft patency and 84% limb salvage. (who.int)
- The CBAS Heparin Surface of a 3 mm diameter GORE® PROPATEN® Vascular Graft (top) remains free of thrombus, while the 3 mm diameter control ePTFE graft (bottom) is covered with thrombus in an acute two-hour in vivo canine carotid artery interposition model. (goremedical.com)
Lower limb ischaemia5
- The presence of diabetes mellitus is rarely addressed in acute lower limb ischaemia (ALLI). (paperity.org)
- Thrombolysis Introduction Local intra-arterial thrombolysis is the preferred treatment option for acute lower limb ischaemia (ALLI) in many vascular centres. (paperity.org)
- Chronic lower limb ischaemia is a slowly progressing disease process that is usually caused by an obliterating arterial disease. (ebm-guidelines.com)
- Acute lower limb ischaemia must be recognized and the patient immediately referred for further management. (ebm-guidelines.com)
- Chronic lower limb ischaemia must be diagnosed and its severity (stage) assessed, as the severity of the condition will determine management approach. (ebm-guidelines.com)
- Bio Dr. Mikkineni is a vascular surgeon who specializes in vascular disease including critical limb ischemia and limb salvage, abdominal and thoracic aortic aneurysms. (stanford.edu)
- Ischemia was the indication for operation for seven of the patients and infected aortic prostheses for three. (elsevier.com)
Terms of limb1
- The only long-term prospective randomized study comparing bypass surgery with PTA showed no significant difference in patency rate or limb salvage. (appliedradiology.com)
- In this article, a successful salvage of a limb with an axillofemoral bypass surgery in a critical leg ischemia subsequently developed soon after an acute myocardial infarction was reported. (e-cvsi.org)
- We performed LAx-PF bypass surgery to successfully rescue the limb, which was on the verge of necrosis. (biomedcentral.com)
Severe limb ischemia1
- The Excimer laser has been approved for use in treating: · Long, diffuse lower limb arterial disease. (advfn.com)
- The chronic ischaemia groups was predominantly secondary to atherosclerotic arterial occlusive disease and not Thrombo Angitis obliterans contrary to the local belief. (who.int)
- Acute arterial occlusive disease in the right lower limb was suspected. (unboundmedicine.com)
- The following services are offered on an individualised basis depending on what is best for each patient considering his general health, disease extent and limb status. (amritahospitals.org)
- Aim The objective of this study was to describe the efficacy, results, and safety of UGFS for treating superficial venous disease of the lower limbs. (eg.net)
- Ischemia reperfusion injury (IR injury) associated with ischemic heart disease contributes significantly to morbidity and mortality. (mdpi.com)
- We present a case of 52 years old man with past medical history of IHD (2 vessel disease and stented 6 times) and dilated cardiomyopathy presented to us with Acute Limb Ischemia. (m-jem.com)
- A computed tomography angiogram (CTA) of the abdomen and lower limb was performed and demonstrated showed an aorta-iliac occlusive disease involving the infrarenal abdominal aorta. (m-jem.com)
- The limb salvage program provides for the multidisciplinary inclusion of the specialties of wound care, vascular surgery, nursing care, physical therapy and other disciplines as identified including, but not limited to infectious disease, nutrition, diabetes management, etc. (lcmh.org)
- Patient with acute limb-threatening ischemia, bone fractures in the relevant areas, nonatherosclerotic disease (e.g. arteriitis) and documented hypercoagulable diseases will be excluded from this study. (clinicaltrials.gov)
Options for acute limb1
Management of acute limb1
- Without question, successful diagnosis, treatment and management of acute limb ischemia involves a complete understanding of the anatomy of the arterial blockage, as well as knowledge of a patient's present and past health, their family history, lifestyle and consideration of the extent of ischemia they're experiencing. (drbenvenisty.com)
- The presence of lower patency rates with discordant higher limb salvage rates in the same patient groups has prompted clinicians in the field to ask why this occurs and even to doubt the value of perfusion in CLI. (vasculardiseasemanagement.com)
- Our patient made an excellent recovery, both in terms of his abdomen that in terms of his lower limbs. (scirp.org)
- In evaluating a patient with concern for acute stroke with atypical presentation, it is essential to obtain a complete history and perform a rapid and thorough examination. (unboundmedicine.com)
- In relation to patient characteristics, Chandra referred to data demonstrating that other than the increase in patients and limbs cared for, there was no difference in terms of age, sex and comorbidities that were cared for-showing that the same type, and demographics of patients were being treated. (vascularnews.com)
- Varicose veins patients (67 limbs) were examined using vascular ultrasound first in 30° reverse Trendelemburg (decubitus) and then in a standing position in the same patient. (jscimedcentral.com)
- In all stages of ischaemia, the patient will complain of cold feet and the skin is cold to touch. (ebm-guidelines.com)
- Abed R, Rajper N, Puma J, Ratcliffe J (2020) Transpedal Approach for the Treatment of Acute Limb Ischemia in a Patient with Limited Access Sites. (clinmedjournals.org)
- A 64-year-old male patient was admitted to our hospital for acute left lower limb ischemia. (biomedcentral.com)
- Occasionally the allograft will improve with time as the ischemia/reperfusion injury recovers, but the patient may need hemodialysis during this time. (clinicaladvisor.com)
- 摘要：Critical limb ischemia (CLI) is an already significant and growing epidemiologic problem with substantial implications for patient mortality, quality of life, and healthcare costs. (cnki.net)
- Other scoring systems include the Predictive Salvage Index, Limb Salvage Index, Nerve Injury, Ischaemia, Soft tissue injury, Skeletal injury, Shock and Age of patient score and Gustillo-Anderson score. (bmj.com)
Morbidity and morta2
- Restoration of blood supply to an organ after a critical period of ischemia causes additional tissue damage and organ dysfunction leading to significant morbidity and mortality. (hindawi.com)
- A timely diagnosis and treatment is of utmost importance to decrease morbidity and mortality and to salvage the limb's functionality. (etsu.edu)
Patients with acute2
- This review describes the pathophysiological effects of plasminogen activators and how, in the future, their non-fibrinolytic functions could be used for the treatment of patients with acute ischaemic and haemorrhagic stroke. (kingsthrombosiscentre.org.uk)
- The company has patented and developed the non-invasive autoRIC ® device, which delivers remote ischemic conditioning therapy ("RIC") to patients with acute and chronic cardiovascular conditions. (tt.se)
- Postoperative examination showed a pulse in the dorsalis pedis artery and posterior tibial artery of the bilateral lower limbs. (biomedcentral.com)
- On neurologic examination, The power of both lower limbs were 2/5 over the bilateral lower limb, with intact sensation was still intact with subjective complaint of numbness and tingling on his bilateral lower limb. (m-jem.com)
- Working diagnosis of Acute Limb Ischemia of bilateral lower limb was made.Emergent phone referral was made with to a vascular surgeon and an interventional radiologist were initiated. (m-jem.com)
- Acute limb ischemia in high risk patients are common, however involving bilateral lower limb is a rare condition. (m-jem.com)
- Univariate analysis showed as demographics data and risk factor variables did not influence the primary, assisted primary, secondary patency rate and limb salvage. (annaliitalianidichirurgia.it)
- Higher primary and secondary patency, and higher limb salvage for below-knee bypass compared to standard ePTFE from 1-3 years. (goremedical.com)
- There were no significant differences in limb salvage or mortality at 30 days, six months, or one year. (clinicaladvisor.com)
- Mortality is closely linked with the presence of pain at rest or tissue-loss, so-called" critical limb ischemia," with a 1-year mortality rate that approximates 20%in several series. (ispub.com)
- Simultaneously, the case fatality rate of acute PE has been decreasing and no significant change in its mortality has been noted, suggesting that the additional PE diagnoses are less severe and these patients might not benefit from anticoagulation therapy. (unboundmedicine.com)
- Salvage attempts can be associated with prolonged hospitalisations, increased costs, multiple procedures and increased mortality. (bmj.com)
- It is a formidable vascular problem with significant limb loss and mortality. (naver.com)
- Future therapies should aim to improve limb salvage and mortality rates. (naver.com)