Acute kidney injury. Medical search

Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys.

Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.

A biochemical abnormality referring to an elevation of BLOOD UREA NITROGEN and CREATININE. Azotemia can be produced by KIDNEY DISEASES or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed UREMIA.

Pathological processes of the KIDNEY or its component tissues.

Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.

A disease or state in which death is possible or imminent.

Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.

Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.

Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.

Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.

An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.

Decreased URINE output that is below the normal range. Oliguria can be defined as urine output of less than or equal to 0.5 or 1 ml/kg/hr depending on the age.

Hospital units providing continuous surveillance and care to acutely ill patients.

The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.

Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.

Surgery performed on the heart.

The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Examination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.

Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Elements of limited time intervals, contributing to particular results or situations.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.

Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.

Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.

The transference of a kidney from one human or animal to another.

Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Substances used to allow enhanced visualization of tissues.

Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Disease having a short and relatively severe course.

Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)

The period before a surgical operation.

A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.

Death of cells in the KIDNEY CORTEX, a common final result of various renal injuries including HYPOXIA; ISCHEMIA; and drug toxicity.

The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.

Injuries incurred during participation in competitive or non-competitive sports.

The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.

Extracorporeal ULTRAFILTRATION technique without HEMODIALYSIS for treatment of fluid overload and electrolyte disturbances affecting renal, cardiac, or pulmonary function.

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.

Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).

A glycosyl-phosphatidyl-inositol (GPI) - anchored membrane protein found on the thick ascending limb of the LOOP OF HENLE. The cleaved form of the protein is found abundantly in URINE.

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

Condition where a primary dysfunction of either heart or kidney results in failure of the other organ (e.g., HEART FAILURE with worsening RENAL INSUFFICIENCY).

The period of confinement of a patient to a hospital or other health facility.

The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

The circulation of the BLOOD through the vessels of the KIDNEY.

Inflammation of any part of the KIDNEY.

Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

Mechanisms of action and interactions of the components of the IMMUNE SYSTEM.

The combination of hemodialysis and hemofiltration either simultaneously or sequentially. Convective transport (hemofiltration) may be better for removal of larger molecular weight substances and diffusive transport (hemodialysis) for smaller molecular weight solutes.

A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.

Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.

An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.

A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.

The presence of proteins in the urine, an indicator of KIDNEY DISEASES.

Health care provided to a critically ill patient during a medical emergency or crisis.

A radiopaque medium used for urography, angiography, venography, and myelography. It is highly viscous and binds to plasma proteins.

A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

Excision of kidney.

Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Inorganic compounds that contain iodine as an integral part of the molecule.

Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.

Bites by snakes. Bite by a venomous snake is characterized by stinging pain at the wound puncture. The venom injected at the site of the bite is capable of producing a deleterious effect on the blood or on the nervous system. (Webster's 3d ed; from Dorland, 27th ed, at snake, venomous)

General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

General or unspecified injuries involving the leg.

The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.

Agents that promote the excretion of urine through their effects on kidney function.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.

The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.

A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.

Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.

Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

A genus of snakes of the family VIPERIDAE. It is distributed in West Pakistan, most of India, Burma, Ceylon, Thailand, southeast China, Taiwan, and a few islands of Indonesia. It hisses loudly when disturbed and strikes with great force and speed. Very prolific, it gives birth to 20-60 young. This viper is the leading cause of snakebite in India and Burma. (Moore: Poisonous Snakes of the World, 1980, p127)

A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.

A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.

A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.

Delivery of substances through VENIPUNCTURE into the VEINS.

The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.

A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.

Strains of mice arising from a parental inbred stock that was subsequently used to produce substrains of knockout and other mutant mice with targeted mutations.

The confinement of a patient in a hospital.

The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.

A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

A surgical specialty concerned with diagnosis and treatment of disorders of the heart, lungs, and esophagus. Two major types of thoracic surgery are classified as pulmonary and cardiovascular.

Chemicals that are used to oxidize pigments and thus effect whitening.

Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.

Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.

Disturbances in the body's WATER-ELECTROLYTE BALANCE.

The refined fixed oil obtained from the seed of one or more cultivated varieties of Sesamum indicum. It is used as a solvent and oleaginous vehicle for drugs and has been used internally as a laxative and externally as a skin softener. It is used also in the manufacture of margarine, soap, and cosmetics. (Dorland, 28th ed & Random House Unabridged Dictionary, 2d ed)

Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.

Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.

Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.

Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.

A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).

Triiodo-substituted derivatives of BENZOIC ACID.

Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characterized by FEVER, uterine tenderness, and foul discharge.

Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.

Hospital units providing continuous surveillance and care to acutely ill infants and children. Neonates are excluded since INTENSIVE CARE UNITS, NEONATAL is available.

Sudden slips on a fault, and the resulting ground shaking and radiated seismic energy caused by the slips, or by volcanic or magmatic activity, or other sudden stress changes in the earth. Faults are fractures along which the blocks of EARTH crust on either side have moved relative to one another parallel to the fracture.

The presence of albumin in the urine, an indicator of KIDNEY DISEASES.

Artificial organs that are composites of biomaterials and cells. The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin.

The mechanical laws of fluid dynamics as they apply to urine transport.

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Animals that are generated from breeding two genetically dissimilar strains of the same species.

Acute renal failure caused by nephrotoxins. (1/3360)

Renal micropuncture studies have greatly changed our views on the pathophysiology of acute renal failure caused by nephrotoxins. Formerly, this type of renal insufficiency was attributed to a direct effect of the nephrotoxins on tubule epithelial permeability. According to that theory, glomerular filtration was not greatly diminished, the filtrate formed being absorbed almost quantitatively and nonselectively across damaged tubule epithelium. Studies in a wide variety of rat models have now shown glomerular filtration to be reduced to a level which will inevitably cause renal failure in and of itself. Passive backflow of filtrate across tubular epithelium is either of minor degree or nonexistent even in models where frank tubular necrosis has occurred. This failure of filtration cannot be attributed to tubular obstruction since proximal tubule pressure is distinctly subnormal in most models studied. Instead, filtration failure appears best attributed to intrarenal hemodynamic alterations. While certain facts tend to incriminate the renin-angiotensin system as the cause of the hemodynamic aberrations, others argue to the contrary. The issue is underactive investigation. (+info)

Sodium reabsorption and distribution of Na+/K+-ATPase during postischemic injury to the renal allograft. (2/3360)

BACKGROUND: A loss of proximal tubule cell polarity is thought to activate tubuloglomerular feedback, thereby contributing to glomerular filtration rate depression in postischemic acute renal failure (ARF). METHODS: We used immunomicroscopy to evaluate the segmental distribution of Na+/K+-ATPase in tubules of recipients of cadaveric renal allografts. Fractional excretion (FE) of sodium and lithium was determined simultaneously. Observations were made on two occasions: one to three hours after graft reperfusion (day 0) and again on post-transplant day 7. An inulin clearance below or above 25 ml/min on day 7 was used to divide subjects into groups with sustained (N = 15) or recovering (N = 16) ARF, respectively. RESULTS: In sustained ARF, the fractional excretion of sodium (FENa) was 40 +/- 6% and 11 +/- 5%, and the fractional excretion of lithium (FELi) was 76 +/- 5% and 70 +/- 2% on days 0 and 7, respectively. Corresponding findings in recovering ARF were 28 +/- 2% and 6 +/- 2% for the FENa and 77 +/- 4% and 55 +/- 3% (P < 0.05 vs. sustained) for FELi. Na+/K+-ATPase distribution in both groups was mainly basolateral in distal straight and convoluted tubule segments and collecting ducts. However, Na+/K+-ATPase was poorly retained in the basolateral membrane of proximal convoluted and straight tubule segments in sustained and recovering ARF on both days 0 and 7. CONCLUSIONS: We conclude that loss of proximal tubule cell polarity for Na+/K+-ATPase distribution is associated with enhanced delivery of filtered Na+ to the macula densa for seven days after allograft reperfusion. Whether an ensuing activation of tubuloglomerular feedback is an important cause of glomerular filtration rate depression in this form of ARF remains to be determined. (+info)

Endothelin up-regulation and localization following renal ischemia and reperfusion. (3/3360)

BACKGROUND: Endothelin (ET), a potent vasoconstrictor, is known to play a role in ischemic acute renal failure. Although preproET-1 (ppET-1) mRNA is known to be up-regulated following ischemia/reperfusion injury, it has not been determined which component of the injury (ischemia or reperfusion) leads to initial gene up-regulation. Likewise, although ET-1 peptide expression has been localized in the normal kidney, its expression pattern in the ischemic kidney has not been determined. Therefore, the purpose of this study was twofold: (a) to determine whether ischemia alone or ischemia plus reperfusion is required for the up-regulation of ppET-1 mRNA to occur, and (b) to localize ET-1 peptide expression following ischemia in the rat kidney to clarify better the role of ET in the pathophysiology of ischemia-induced acute renal failure. METHODS: Male Lewis rats underwent clamping of the right renal vascular pedicle for either 30 minutes of ischemia (group 1), 60 minutes of ischemia (group 2), 30 minutes of ischemia followed by 30 minutes of reperfusion (group 3), or 60 minutes of ischemia followed by three hours of reperfusion (group 4). The contralateral kidney acted as a control. ppET-1 mRNA up-regulation and ET-1 peptide expression were examined using the reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. RESULTS: Reverse transcription-polymerase chain reaction yielded a control (nonischemic) value of 0.6 +/- 0.2 densitometric units (DU) of ppET-1 mRNA in the kidney. Group 1 levels (30 min of ischemia alone) were 1.8 +/- 0.4 DU, a threefold increase (P < 0.05). Group 2 levels (60 min of ischemia alone) increased almost six times above baseline, 3.5 +/- 0.2 DU (P < 0.01), whereas both group 3 and group 4 (ischemia plus reperfusion) did not experience any further significant increases in mRNA levels (1.9 +/- 0.4 DU and 2.8 +/- 0.6 DU, respectively) beyond levels in group 1 or 2 animals subjected to similar ischemic periods. ET-1 peptide expression in the ischemic kidneys was significantly increased over controls and was clearly localized to the endothelium of the peritubular capillary network of the kidney. CONCLUSIONS: Initial ET-1 gene up-regulation in the kidney occurs secondary to ischemia, but reperfusion most likely contributes to sustaining this up-regulation. The marked increase of ET-1 in the peritubular capillary network suggests that ET-induced vasoconstriction may have a pathophysiological role in ischemic acute tubular necrosis. (+info)

Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application. (4/3360)

Efficient and safe heparin anticoagulation has remained a problem for continuous renal replacement therapies and intermittent hemodialysis for patients with acute renal failure. To make heparin therapy safer for the patient with acute renal failure at high risk of bleeding, we have proposed regional heparinization of the circuit via an immobilized heparinase I filter. This study tested a device based on Taylor-Couette flow and simultaneous separation/reaction for efficacy and safety of heparin removal in a sheep model. Heparinase I was immobilized onto agarose beads via cyanogen bromide activation. The device, referred to as a vortex flow plasmapheretic reactor, consisted of two concentric cylinders, a priming volume of 45 ml, a microporous membrane for plasma separation, and an outer compartment where the immobilized heparinase I was fluidized separately from the blood cells. Manual white cell and platelet counts, hematocrit, total protein, and fibrinogen assays were performed. Heparin levels were indirectly measured via whole-blood recalcification times (WBRTs). The vortex flow plasmapheretic reactor maintained significantly higher heparin levels in the extracorporeal circuit than in the sheep (device inlet WBRTs were 1. 5 times the device outlet WBRTs) with no hemolysis. The reactor treatment did not effect any physiologically significant changes in complete blood cell counts, platelets, and protein levels for up to 2 hr of operation. Furthermore, gross necropsy and histopathology did not show any significant abnormalities in the kidney, liver, heart, brain, and spleen. (+info)

Abysmal prognosis of patients with type 2 diabetes entering dialysis. (5/3360)

INTRODUCTION: The importance of non-insulin-dependent diabetes mellitus (type II diabetes) as a leading cause of end-stage renal disease is now widely recognized. The purpose of this study was to assess life-prognosis and its predictors in a cohort of patients newly entering dialysis. MATERIAL AND METHODS: Eighty-four consecutive type II diabetes patients (40% of all patients) starting dialysis between 01/01/95 and 31/12/96 were studied retrospectively, focusing on clinical data at inception and life-prognosis after a mean follow-up of 211 days. Patients were divided into three groups, according to onset of renal failure: acute 11% (9/84), chronic 61% (51/84) and acutely aggravated chronic renal failure 28% (25/84). RESULTS: Patients (mean age 67 years) had long-standing diabetes (mean duration approximately 15 years), heavy proteinuria (approximately 3 g/24h) and diabetic retinopathy (67%). The average creatinine clearance (Cockcroft's formula) was 13 ml/min. Cardiovascular diseases were highly prevalent at the start of dialysis: history of myocardial infarction (26%), angina (36%) and acute left ventricular dysfunction (67%). More than 80% of the patients underwent the first session dialysis under emergency conditions, a situation in part related to late referral to the nephrology division (63% for chronic patients). A great majority of the patients were overhydrated when starting dialysis, as evidenced by the average weight loss of 6 kg, during the first month of dialysis, required to reach dry weight. Nearly 64% of the patients presented high blood pressure (> 140/90 mmHg) when starting dialysis despite antihypertensive therapy (mean: 2.3 drugs). The outcome of this type II diabetes population was dramatic: 32% (27/84) died after a mean follow-up of 211 days, mostly from cardiovascular diseases. The rate of recovery of renal function was low in both the acute and the acutely aggravated renal failure group (30% and 24%, respectively). Of note, iatrogenic nephrotoxic agents accounted for renal function impairment in nearly 30% of patients. CONCLUSION: Our observational study illustrates the high burden of cardiovascular diseases contrasting with sub-optimal cardiovascular therapeutic interventions in type II diabetes patients entering dialysis. Factors aggravating renal failure were mainly iatrogenic, and therefore largely avoidable. Late referral generally implied a poor clinical condition at the start of dialysis. (+info)

Treatment of malarial acute renal failure by hemodialysis. (6/3360)

We studied 112 patients with malarial acute renal failure (ARF) during the period 1991-1997 at Bangkok Hospital for Tropical Diseases (Mahidol University, Bangkok, Thailand). Hemodialysis was performed in 101 (90.2%) of these patients. The mean number of times the patients were hemodialyzed was 6.5 (range = 1-27). Ninety-three (83.0%) patients were oliguric and the remainder were nonoliguric. Patients who had oliguric renal failure required more hemodialyses and had more complications than the nonoliguric patients. The oliguric patients had an eight-fold higher risk of requiring six or more hemodialyses (95% confidence interval = 1.2-53.9, P = 0.0008). The overall mortality rate was 10.7% (12 of 112). Eleven of the patients who died were jaundiced and eight of them had cerebral malaria with a Glasgow Coma Score < or = 8. We conclude that hemodialysis is a useful treatment for oliguric and nonoliguric ARF from severe malaria, particularly when initiated early in the course of the illness. (+info)

Intranephron distribution and regulation of endothelin-converting enzyme-1 in cyclosporin A-induced acute renal failure in rats. (7/3360)

Endothelin-1 (ET-1) is thought to play a significant role in acute renal failure induced by cyclosporin A (CsA). The cDNA sequence encoding endothelin-converting enzyme-1 (ECE-1), which produces the active form of ET-1 from big ET-1, was recently reported. To elicit the role of ECE-1 in the glomerular and tubular dysfunction induced by CsA, the effects of CsA on mRNA and protein expression of ECE-1 in rat kidney and on mRNA expression of prepro-ET-1 and ET A- and B-type receptors in glomeruli were studied. ECE-1 mRNA was detected in glomeruli and in whole nephron segments. ECE-1 mRNA expression was downregulated in all nephron segments at 24 h after CsA injection. Protein levels were also downregulated in glomeruli and in the outer and inner medulla. CsA rapidly increased prepro-ET-1 mRNA expression in glomeruli at 30 to 60 min after injection; this rapid increase was followed by an increase in plasma ET-1 levels. These increases were followed by decreased expression of ECE-1, ET A-type receptor, and ET B-type receptor mRNA at 6 h after injection, and serum creatinine levels were increased at 24 h after CsA injection. It is suggested that downregulation of glomerular and tubular ECE-1 expression may be caused by increased ET-1 synthesis in CsA-induced acute renal failure. (+info)

Prevalence and clinical outcome associated with preexisting malnutrition in acute renal failure: a prospective cohort study. (8/3360)

Malnutrition is a frequent finding in hospitalized patients and is associated with an increased risk of subsequent in-hospital morbidity and mortality. Both prevalence and prognostic relevance of preexisting malnutrition in patients referred to nephrology wards for acute renal failure (ARF) are still unknown. This study tests the hypothesis that malnutrition is frequent in such clinical setting, and is associated with excess in-hospital morbidity and mortality. A prospective cohort of 309 patients admitted to a renal intermediate care unit during a 42-mo period with ARF diagnosis was studied. Patients with malnutrition were identified at admission by the Subjective Global Assessment of nutritional status method (SGA); nutritional status was also evaluated by anthropometric, biochemical, and immunologic parameters. Outcome measures included in-hospital mortality and morbidity, and use of health care resources. In-hospital mortality was 39% (120 of 309); renal replacement therapies (hemodialysis or continuous hemofiltration) were performed in 67% of patients (206 of 309); APACHE II score was 23.1+/-8.2 (range, 10 to 52). Severe malnutrition by SGA was found in 42% of patients with ARF; anthropometric, biochemical, and immunologic nutritional indexes were significantly reduced in this group compared with patients with normal nutritional status. Severely malnourished patients, as compared to patients with normal nutritional status, had significantly increased morbidity for sepsis (odds ratio [OR] 2.88; 95% confidence interval [CI], 1.53 to 5.42, P < 0.001), septic shock (OR 4.05; 95% CI, 1.46 to 11.28, P < 0.01), hemorrhage (OR 2.98; 95% CI, 1.45 to 6.13, P < 0.01), intestinal occlusion (OR 5.57; 95% CI, 1.57 to 19.74, P < 0.01), cardiac dysrhythmia (OR 2.29; 95% CI, 1.36 to 3.85, P < 0.01), cardiogenic shock (OR 4.39; 95% CI, 1.83 to 10.55, P < .001), and acute respiratory failure with mechanical ventilation need (OR 3.35; 95% CI, 3.35 to 8.74, P < 0.05). Hospital length of stay was significantly increased (P < 0.01), and the presence of severe malnutrition was associated with a significant increase of in-hospital mortality (OR 7.21; 95% CI, 4.08 to 12.73, P < 0.001). Preexisting malnutrition was a statistically significant, independent predictor of in-hospital mortality at multivariable logistic regression analysis both with comorbidities (OR 2.02; 95% CI, 1.50 to 2.71, P < 0.001), and with comorbidities and complications (OR 2.12; 95% CI, 1.61 to 2.89, P < 0.001). Malnutrition is highly prevalent among ARF patients and increases the likelihood of in-hospital death, complications, and use of health care resources. (+info)

Zuk, Anna; Bonventre, Joseph V. (2016-01-14). "Acute Kidney Injury". Annual Review of Medicine. 67 (1): 293-307. doi:10.1146/ ... Sharfuddin, Asif A.; Molitoris, Bruce A. (April 2011). "Pathophysiology of ischemic acute kidney injury". Nature Reviews ... Munshi, Raj; Hsu, Christine; Himmelfarb, Jonathan (2011-02-02). "Advances in understanding ischemic acute kidney injury". BMC ... Kidney Ischemia is a loss of blood flow to the kidney cells. Several physical symptoms include shrinkage of one or both kidneys ...

https://en.wikipedia.org/wiki/Ischemia

"Perioperative Acute Kidney Injury". dx.doi.org. doi:10.21203/rs.2.19674/v1. Retrieved 2021-11-29. "Scarlet Oak , The Wood ...

https://en.wikipedia.org/wiki/Quercus_coccinea

... leading to acute kidney injury and the need for transient dialysis in the undiagnosed pheochromocytoma patient as their primary ... "Contrast-Induced Acute Kidney Injury". Journal of the American College of Cardiology. 68 (13): 1465-1473. doi:10.1016/j.jacc. ... Kidney failure is brought about by catecholamine-induced muscle injury. Norepinephrine causes vessels to narrow, thereby ... Furthermore, if an acute adrenal hemorrhage is suspected in a pheochromocytoma patient, ultrasound is a quick, painless, ...

https://en.wikipedia.org/wiki/Pheochromocytoma

Controversies in Acute Kidney Injury , Karger Book. "Textbook of Critical Care - 7th Edition". www.elsevier.com. Retrieved 2022 ... Insuffisance Circulatoire Aiguë Controversies in Acute Kidney Injury Textbook of Critical Care Encyclopedia of Intensive Care ...

https://en.wikipedia.org/wiki/Jean-Louis_Vincent

Bosch X, Poch E, Grau JM (July 2009). "Rhabdomyolysis and acute kidney injury". The New England Journal of Medicine. 361 (1): ... The priority in assessing blunt trauma in sports injuries is separating contusions and musculo-tendinous injuries from injuries ... "Kidney injuries in professional American football: implications for management of an athlete with 1 functioning kidney". The ... Blunt injuries to the kidney from helmets, shoulder pads, and knees are described in American football, association football, ...

https://en.wikipedia.org/wiki/Blunt_trauma

... in the absence of acute kidney injury, and 59% if kidney impairment occurs. Most people who have sustained kidney impairment ... Rhabdomyolysis accounts for 7-10% of all cases of acute kidney injury in the U.S. Crush injuries are common in major disasters ... Rhabdomyolysis complicated by acute kidney impairment in patients with traumatic injury may have a mortality rate of 20%. ... Of those with rhabdomyolysis, 10-50% develop acute kidney injury. The risk is higher in people with a history of illicit drug ...

https://en.wikipedia.org/wiki/Rhabdomyolysis

And neither prevents acute kidney injury. How to prevent perioperative myocardial injury remains under active investigation, ... "Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial". JAMA. 312 (21): 2254-64. doi ... What causes acute surgical pain to become persistent remains unclear. However, it seems likely to result from some combination ... Wang L, Bauer M, Curry R, Larsson A, Sessler DI, Eisenach JC (October 2014). "Intrathecal ketorolac does not improve acute or ...

https://en.wikipedia.org/wiki/Outcomes_Research_Consortium

Prolonged renal ischemia from cardiac arrest leads to acute kidney injury (AKI) in about 40% of patients. While PCAS may ... hypocalcemia and hypomagnesaemia Acute kidney injury is not the leading cause of death after cardiac arrest. However, evidence ... "Acute kidney injury after cardiac arrest". Critical Care. 19 (1): 169. doi:10.1186/s13054-015-0900-2. PMC 4416259. PMID ... typically results in brain injury. Increasingly severe injury can lead to long term consequences such as cognitive dysfunction ...

https://en.wikipedia.org/wiki/Post-cardiac_arrest_syndrome

Drug toxicity includes acute kidney injury. Although used clinically since at least 1962, the mechanism of action of fibrates ... April 2012). "New fibrate use and acute renal outcomes in elderly adults: a population-based study". Annals of Internal ... leading to kidney failure. The less lipophilic statins are less prone to cause this reaction, and are probably safer to be ...

https://en.wikipedia.org/wiki/Fibrate

It may cause acute kidney injury. It is now more commonly used to describe diffuse, fine, renal parenchymal calcification in ... There are several causes of nephrocalcinosis that are typically acute and present only with kidney failure. These include tumor ... It may be severe enough to cause (as well as be caused by) renal tubular acidosis or even end stage kidney disease, due to ... Medullary sponge kidney Distal renal tubular acidosis Hyperoxaluria Renal papillary necrosis And other causes of hypercalcemia ...

https://en.wikipedia.org/wiki/Nephrocalcinosis

... as well as for acute kidney injury (AKI). suPAR may link the innate immune system functionally to the kidney - a novel, ... circulating risk factor for chronic kidney disease (CKD) as well as for acute kidney injury (AKI). suPAR is investigated as ... "Soluble Urokinase Receptor and Acute Kidney Injury". New England Journal of Medicine. nejm.org. 382 (5): 416-426. doi:10.1056/ ... "suPAR is a global risk factor for kidney diseases and lower levels of it are better for any of them. He also compares the ...

https://en.wikipedia.org/wiki/Jochen_Reiser

tremor, acute kidney injury, and decreased appetite. Voclosporin is a cyclosporin A analog, similar to cyclosporin A with ... Lupus nephritis commonly leads patients to chronic kidney failure and therefore places an emphasis on early intervention for ... Early intervention with voclosporin in combination with kidney response is believed to lead to more positive clinical outcomes ... As a result of the calcineurin inhibition, podocytes (cells within the kidneys) are stabilized while inflammation is reduced. ...

https://en.wikipedia.org/wiki/Voclosporin

Post-Contrast Acute Kidney Injury and Contrast-Induced Nephropathy in Adults". ACR Manual on Contrast Media. American College ... Sadat U, Usman A, Gillard JH, Boyle JR (2013). "Does ascorbic acid protect against contrast-induced acute kidney injury in ... Given the increasing doubts about the contribution of radiocontrast to acute kidney injury, the American College of Radiology ... has proposed the name contrast-associated acute kidney injury (CA-AKI) (formerly referred to as post-contrast acute kidney ...

https://en.wikipedia.org/wiki/Contrast-induced_nephropathy

August 2014). "Acute kidney injury associated with smoking synthetic cannabinoid". Clinical Toxicology. 52 (7): 664-73. doi: ... Adverse effects observed due to synthetic cannabinoid use include acute kidney injury, cardiac toxicity, seizure, stroke, ... reported acute kidney injury. Four postmortem cases linked to the synthetic cannabinoids 5F-PB-22 have been reviewed. The ... Abouchedid R, Ho JH, Hudson S, Dines A, Archer JR, Wood DM, Dargan PI (December 2016). "Acute Toxicity Associated with Use of ...

https://en.wikipedia.org/wiki/Synthetic_cannabinoids

Acute kidney injury and seizures can also occur. Onset of symptoms can be rapid, with a headache developing in 15 minutes and ...

https://en.wikipedia.org/wiki/Eastern_brown_snake

Fanos V, Antonucci R, Zaffanello M (2010). "Ibuprofen and acute kidney injury in the newborn". The Turkish Journal of ... acute kidney failure, cyanosis, respiratory depression, and cardiac arrest have been reported. The severity of symptoms varies ... In October 2020, the US FDA required the drug label to be updated for all NSAID medications to describe the risk of kidney ... It increases the risk of heart failure, kidney failure, and liver failure. At low doses, it does not appear to increase the ...

https://en.wikipedia.org/wiki/Ibuprofen

"Causal relationship between hypoalbuminemia and acute kidney injury". World Journal of Nephrology. 6 (4): 176-187. doi:10.5527/ ... "Lupus and Kidney Disease (Lupus Nephritis) , NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. ... In severe cases where the condition has progressed to chronic kidney disease, kidney transplantation will be ultimately be ... the progression to kidney disease is very common and individuals will inevitably require kidney transplant. If left untreated ...

https://en.wikipedia.org/wiki/Glomerulonephrosis

"Fluid Management and Use of Diuretics in Acute Kidney Injury". Advances in Chronic Kidney Disease. 20 (1): 45-55. doi:10.1053/j ... However, fluid overload can exacerbate acute kidney injury. The use of diuretics does not prevent or treat AKI even with the ... Sepsis accounts for 50% of acute kidney injury patients in (intensive care unit) (ICU). Intravenous crystalloid is recommended ... W Schrier, Robert (2010). "Fluid Administration in Critically Ill Patients with Acute Kidney Injury". Clinical Journal of the ...

https://en.wikipedia.org/wiki/Fluid_replacement

... acute kidney injury, and mortality". J Am Soc Nephrol. 21 (5): 845-51. doi:10.1681/ASN.2009070682. PMC 2865737. PMID 20395373 ... Bell et al., in 2013, surveyed 91 acute hospital sites in England to evaluate systems of consultant cover for acute medical ... Injury. 47 (6): 1236-41. doi:10.1016/j.injury.2016.02.021. PMID 27084114.{{cite journal}}: CS1 maint: multiple names: authors ... "The weekend effect alters the procurement and discard rates of deceased donor kidneys in the United States". Kidney Int. 90 (1 ...

https://en.wikipedia.org/wiki/Weekend_effect

"Contrast medium induced acute kidney injury: a narrative review". Journal of Nephrology. 31 (6): 797-812. doi:10.1007/s40620- ... Wang AL, Wang JP, Wang H, Chen YH, Zhao L, Wang LS, Wei W, Xu DX (March 2006). "A dual effect of N-acetylcysteine on acute ... This may lead to severe liver damage and even death by acute liver failure. In the treatment of paracetamol (acetaminophen) ... It is most effective in preventing or lessening hepatic injury when administered within 8-10 hours after overdose. Research ...

https://en.wikipedia.org/wiki/Acetylcysteine

Yang X, de Caestecker M, Otterbein LE, Wang B (July 2020). "Carbon monoxide: An emerging therapy for acute kidney injury". ... acute kidney failure, skin lesions, and visual and auditory problems. Carbon monoxide exposure may lead to a significantly ... Sokal JA (December 1985). "The effect of exposure duration on the blood level of glucose, pyruvate and lactate in acute carbon ... From the available data, carbon monoxide poisoning is the most common cause of injury and death due to poisoning worldwide. ...

https://en.wikipedia.org/wiki/Carbon_monoxide_poisoning

Humphreys, BD; Duffield, JS; Bonventre, JV (2006). "Renal stem cells in recovery from acute kidney injury". Minerva Urologica e ... It is involved in the homeostasis and repair of the kidney, and holds therapeutic potential for treatment of kidney failure. ... "Intrinsic Epithelial Cells Repair the Kidney after Injury". Cell Stem Cell. 2 (3): 284-91. doi:10.1016/j.stem.2008.01.014. PMID ... "Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury". Stem Cells. 28 (3): ...

https://en.wikipedia.org/wiki/Renal_stem_cell

Of those 27 analyzed cases, nine developed liver injury; there were also three instances of acute kidney injury. As gyromitrin ... Dialysis can be used if kidney function is impaired or the kidneys are failing. Hemolysis may require a blood transfusion to ... which can lead to kidney toxicity or kidney failure. Methemoglobinemia may also occur in some cases. This is where higher than ... Braun R, Greeff U, Netter KJ (1979). "Liver injury by the false morel poison gyromitrin". Toxicology. 12 (2): 155-63. doi: ...

https://en.wikipedia.org/wiki/Gyromitrin

Yang X, de Caestecker M, Otterbein LE, Wang B (July 2020). "Carbon monoxide: An emerging therapy for acute kidney injury". ... H 2S deficiency can be detrimental to the vascular function after an acute myocardial infarction (AMI). H 2S therapy reduces ... March 2008). "Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion ... "Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells". Leukemia ...

https://en.wikipedia.org/wiki/Gasotransmitter

Yang X, de Caestecker M, Otterbein LE, Wang B (July 2020). "Carbon monoxide: An emerging therapy for acute kidney injury". ... liver and kidney are significantly less tolerant than skeletal muscle), failure to expel carbon dioxide may cause respiratory ...

https://en.wikipedia.org/wiki/Carboxyhemoglobin

"Risk Factors for Acute Kidney Injury in Severe Rhabdomyolysis." PLOSONE 10.1371 (2013). Web. 25 Jan 2014. Poortsmans, JR. ... In some cases ER can lead to acute kidney failure and bring medical costs up due to the need for hemodialysis for recovery/ ... Acute Exertional Rhabdomyolysis. Aug. 1995 Retrieved 22 Jan. 2014 Jooyoung Kim, Joohyung Lee, Sojung Kim, Ho Young Ryu, Kwang ... Vanderstraten, J. "Kidney function during exercise in healthy and diseased human. An Update." Sports Medicine 18.6 (1994): 419- ...

https://en.wikipedia.org/wiki/Exertional_rhabdomyolysis

"Acute kidney injury in late pregnancy in developing countries". Renal Failure. 32 (3): 309-313. doi:10.3109/08860221003606265. ... of all cases of acute kidney failure in adults and more than 20% of cases of acute kidney failure during late pregnancy. While ... Renal cortical necrosis (RCN) is a rare cause of acute kidney failure. The condition is "usually caused by significantly ... Rapidly corrected acute renal ischemia leads to acute tubular necrosis, from which complete recovery is possible, while more ...

https://en.wikipedia.org/wiki/Renal_cortical_necrosis

Hospital-acquired acute kidney injury fell by more than 80%. This saved the trust more than £2 million in direct costs. The ... It set up an artificial intelligence model using risk stratification digital tools to protect patients from acute kidney injury ... It runs two acute hospitals in University Hospital of North Durham and Darlington Memorial Hospital as well as further non- ... acute centres at Shotley Bridge Hospital, Sedgefield Community Hospital, Richardson Community Hospital, Weardale Community ...

https://en.wikipedia.org/wiki/County_Durham_and_Darlington_NHS_Foundation_Trust

An analysis of over 900 orlistat users in Ontario showed that their rate of acute kidney injury was more than triple that of ... April 2011). "Orlistat and acute kidney injury: an analysis of 953 patients". Archives of Internal Medicine. 171 (7): 703-4. ... The study showed no evidence of an increased risk of liver injury during treatment. They concluded: The incidence of acute ... "Orlistat and the risk of acute liver injury: self controlled case series study in UK Clinical Practice Research Datalink". BMJ ...

https://en.wikipedia.org/wiki/Orlistat

"Fluid Management and Use of Diuretics in Acute Kidney Injury". Advances in Chronic Kidney Disease. 20 (1): 45-55. doi:10.1053/j ... Diuretics has not shown any benefits of preventing or treating acute kidney injury. They are also sometimes used in the ... guidelines stated that diuretics should not be used to treat acute kidney injury, except for the management of volume overload ... Chronic kidney disease (CKD) reduces renal flow rate, reducing the delivery of diuretic molecules into the nephron, limiting ...

https://en.wikipedia.org/wiki/Loop_diuretic

Most fetal birth injuries resolve without long term harm, but brachial plexus injury may lead to Erb's palsy or Klumpke's ... Hypoxic damage can also occur to most of the infant's organs (heart, lungs, liver, gut, kidneys), but brain damage is of most ... The postpartum period can be divided into three distinct stages; the initial or acute phase, six to 12 hours after childbirth; ... 20 or 30 encounter injuries, infections or disabilities. Most of these deaths and injuries are preventable. In 2008, noting ...

https://en.wikipedia.org/wiki/Childbirth

The acute medical care unit runs 24 hours. Dr. W. C. Gray was the first professor and head. Jeypore Sri Vikram Deo Varma Medal ... An exclusive unit of 'Head Injury and Intensive Care' was started in 1991. Superspeciality course (M.Ch.) was started in 1986. ... who has been instrumental in developing the Kidney transplantation facility in the hospital. Department of Neurology Department ...

https://en.wikipedia.org/wiki/Andhra_Medical_College

A fraction of these patients were also found to have acute kidney injury. Coniine is toxic for the kidneys because it leads to ... Coniine also has significant toxic effects on the kidneys. The presence of rhabdomyolysis and acute tubular necrosis has been ... Acute toxicity, if not lethal, may resolve in spontaneous recovery, provided further exposure is avoided. Death can be ... 1991). "Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis ...

https://en.wikipedia.org/wiki/Conium_maculatum

Other risk factors: Lack of sufficient insulin (but enough to prevent ketosis) Poor kidney function Poor fluid intake ( ... stroke or another acute illness. A relative insulin deficiency leads to a serum glucose that is usually higher than 33 mmol/L ( ... dehydration) Older age (50-70 years) Certain medical conditions (cerebral vascular injury, myocardial infarction, sepsis) ...

https://en.wikipedia.org/wiki/Hyperosmolar_hyperglycemic_state

Miller RH, Azar FM, Throckmorton TW (2021). "Chapter 46: Shoulder and Elbow Injuries". In Azar FM, Beaty JH (eds.). Campbell's ... or sharp acute pain that worsens at night. Calcific tendinitis is typically diagnosed by physical exam and X-ray imaging. The ... and metabolic disorders that also cause kidney stones, gallstones, and gout. Occupations that consist of repetitive overhead ... many experience severe acute pain that worsens at night. Those affected tend to hold the shoulder rotated inwards to alleviate ...

https://en.wikipedia.org/wiki/Calcific_tendinitis

... acute kidney injury, and vasculitis. The production of IL-1, IL-2, IL-6, TNF-alpha, and interferon-gamma, all crucial ... The virus can cause acute myocardial injury and chronic damage to the cardiovascular system. An acute cardiac injury was found ... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel severe acute respiratory syndrome coronavirus. It was ... but acute myocardial injuries may also be related to ACE2 receptors in the heart. ACE2 receptors are highly expressed in the ...

https://en.wikipedia.org/wiki/COVID-19

X-ray Acute abdomen Abdominal pain Medical imaging Chest x-ray Radiographer "Radiology - Acute indications". Royal Children's ... KUB stands for Kidneys, Ureters, and Bladder. The KUB projection does not necessarily include the diaphragm. The projection ... Yet, CT scan is the best alternative for diagnosing intra-abdominal injury. Computed tomography provides an overall better ... Kidneys, ureters, and bladder imaging: plain films of the abdomen. Updated 27 Aug 2015. (Articles with short description, Short ...

https://en.wikipedia.org/wiki/Abdominal_x-ray

... is characterized by elevated blood calcium levels, metabolic alkalosis, and acute kidney injury. Milk- ... and acute kidney injury. In general, milk-alkali syndrome starts with excess calcium levels in the body (hypercalcemia), which ... Underlying kidney disease is a risk factor for MAS, but even people with healthy kidneys can develop the syndrome. For a ... "Hypercalcemia-Induced ST-Segment Elevation Mimicking Acute Myocardial Injury: A Case Report and Review of the Literature". Case ...

https://en.wikipedia.org/wiki/Milk-alkali_syndrome

... is classified as a "renal" (i.e. not pre-renal or post-renal) cause of acute kidney injury. Diagnosis is ... is preferred by pathologists over the older name acute tubular necrosis (ATN). ATN presents with acute kidney injury (AKI) and ... May 1993). "Morphology of ischemic acute kidney injury, normal function, and cyclosporine toxicity in cyclosporine-treated ... Racusen LC (1998). "Epithelial cell shedding in acute renal injury". Clinical and Experimental Pharmacology & Physiology. 25 (3 ...

https://en.wikipedia.org/wiki/Acute_tubular_necrosis

... recent pet food recalls concluded that the combination of melamine and cyanuric acid in diet does lead to acute kidney injury ...

https://en.wikipedia.org/wiki/Melamine_cyanurate

Retrieved 14 October 2021.. " "Scorpion envenomation causing skin necrosis, hemolysis, DIC, and acute kidney injury (Middle ... In 1997, The dogma of avoiding analgesics in patients with acute abdominal pain was challenged, and in one of the first studies ... LoVecchio also investigated the influence of the infecting pathogen on the hospital length of stay (LOS) for acute ... "Administration of analgesics in patients with acute abdominal pain: a survey of the practice of doctors in a developing country ...

https://en.wikipedia.org/wiki/Frank_LoVecchio

H-FABP has been proven to significantly predict 30-day mortality in acute pulmonary embolism. H-FABP is more effective than ... The diagnostic potential of the biomarker H-FABP for heart injury was discovered in 1988 by Professor Jan Glatz (Maastricht, ... it is found at 10-fold lower levels in skeletal muscle than heart muscle and the amounts in the kidney, liver and small ... Pelsers MM, Hermens WT, Glatz JF (Feb 2005). "Fatty acid-binding proteins as plasma markers of tissue injury". Clinica Chimica ...

https://en.wikipedia.org/wiki/Heart-type_fatty_acid_binding_protein

The use of fluoroscopy requires radiopaque contrast, which in rare cases can lead to contrast-induced kidney injury (see ... Acute coronary syndromes: ST elevation MI (STEMI), non-ST Elevation MI (NSTEMI), and unstable angina Evaluation of coronary ... chronic kidney disease, and unstable angina. Left heart catheterization (LHC) is an ambiguous term and sometime clarification ...

https://en.wikipedia.org/wiki/Cardiac_catheterization

Jack Warden, 85, American actor Emmy Award-winning (Heaven Can Wait, While You Were Sleeping), heart and kidney failure. George ... June Allyson, 88, American actress, dancer and singer, pulmonary respiratory failure and acute bronchitis after a long illness ... Goldstein, Richard (July 17, 2006). "James Nicholas, 85, Leader in Treating Sports Injuries, Dies". The New York Times. ... Floyd Dixon, 77, American R&B pianist, kidney failure. Vincent J. Fuller, 75, American lawyer who defended John Hinckley, Jr., ...

https://en.wikipedia.org/wiki/Deaths_in_July_2006

The presentation of acute appendicitis includes acute abdominal pain, nausea, vomiting, and fever. As the appendix becomes more ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 11 November 2020. ... "Appendicitis". National Institute of Diabetes and Digestive and Kidney Diseases. U.S. Department of Health and Human Services. ... Perman's sign: In acute appendicitis palpation in the left iliac fossa may produce pain in the right iliac fossa. While there ...

https://en.wikipedia.org/wiki/Appendicitis

... a mahjong video game Acute kidney injury Anti Knock Index of motor fuel Aki (name), a list of people and characters with the ...

https://en.wikipedia.org/wiki/Aki

... kidney failure. Morton Deutsch, 97, American social psychologist. Diphan, 45, Indian film director, kidney problems. Vincent ... injuries sustained in bomb explosion. Gilbert Baker, 65, American artist and gay activist, creator of the rainbow flag. Richard ... complications from acute bronchitis. August Englas, 92, Estonian wrestler, world champion (1953, 1954). Roy Fisher, 86, British ... Roger Hau'ofa, 73, Tongan-born Papua New Guinean radio broadcaster, kidney failure. John Holliman, 72, British Anglican priest ...

https://en.wikipedia.org/wiki/Deaths_in_March_2017

Causes of neuritis include: Physical injury Infection Diphtheria Herpes zoster (shingles) Leprosy Lyme disease Chemical injury ... Peripheral neuropathy may be acute (with sudden onset, rapid progress) or chronic (symptoms begin subtly and progress slowly), ... chronic kidney failure, porphyria, amyloidosis, liver failure, hypothyroidism Idiopathic peripheral neuropathy refers to ... sports injury, sports pinching, cutting, projectile injuries (for example, gunshot wound), strokes including prolonged ...

https://en.wikipedia.org/wiki/Peripheral_neuropathy

... acute kidney injury and respiratory insufficiency, severe metabolic alterations and cerebral edema that can lead to brain death ... Hassanein, T; Oliver, D; Stange, J; Steiner, C (2003). "Albumin dialysis in cirrhosis with superimposed acute liver injury: ... Kjaergard, LL; Liu, J; Als-Nielsen, B; Gluud, C (2003). "Artificial and bioartificial support systems for acute and acute-on- ... Khuroo, MS; Khuroo, MS; Farahat, KL (September 2004). "Molecular adsorbent recirculating system for acute and acute-on-chronic ...

https://en.wikipedia.org/wiki/Liver_support_system

Csillag, Ron (January 26, 2012). "Brilliant biochemist was an authority on the immunology of burn injury". The Globe and Mail. ... Kim Geun-tae, 64, South Korean politician, Minister of Health and Welfare (2004-2006), pneumonia and kidney failure. Richard ... Tetsuzo Fuyushiba, 75, Japanese politician, Minister of Land, Infrastructure, Transport and Tourism (2006-2008), acute ... Carmen Rupe, 75, New Zealand transsexual entertainer, kidney failure. Fevzi Şeker, 49, Turkish wrestler, heart attack. Mario ...

https://en.wikipedia.org/wiki/Deaths_in_December_2011

... with antlers have more acute hearing than those without antlers; a study of trophy antlers using a microphone found that ... Cadmium levels are high in Finnish moose liver and kidneys, with the result that consumption of these organs from moose more ... bacterial infection due to injuries sustained from predators, and parasites from white-tailed deer to which moose have not ... However the consumption of moose liver or kidneys significantly increased cadmium intake, with the study revealing that heavy ...

https://en.wikipedia.org/wiki/Moose

In southern France, some people were inflicted with acute kidney injury because they accidentally consumed A. proxima, ... A. proxima is found in the same habitats as A. ovoidea, and can cause cytolytic hepatitis and acute renal failure. Amanita ... 1998). Acute renal insufficiency caused by Amanita proxima poisoning: experience of the Poison Center of Marseille. Nephrologie ...

https://en.wikipedia.org/wiki/Amanita_ovoidea

Ischemic Heart Disease Cerebrovascular Disease Alzheimer Disease COPD Lung Cancer Diabetes Chronic Kidney Disease Road Injuries ... The COVID-19 pandemic in Turkey is part of the ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute ... Furthermore many more Turks die from Diabetic Kidney disease, a complication of Diabetes and non-diabetic High blood sugar, and ...

https://en.wikipedia.org/wiki/Health_in_Turkey

Acute kidney injury: changing lexicography, definitions, and epidemiology. Kidney Int, 2007 Himmelfarb, J, Phinney, S, Ikizler ... Timing of initiation of dialysis in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol, 1(5), 915-9, 2006 ... Survival by dialysis modality in critically ill patients with acute kidney injury. J Am Soc Nephrol, 17(11), 3132-8, 2006 ... A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int, 73( ...

https://en.wikipedia.org/wiki/Alp_Ikizler

Two different types of infection exist for this disease, "acute" and "chronic." Acute Hepatitis B is a short-term illness that ... brush injuries and injuries with dead tissues. Although rare, a person may also become infected with tetanus through ... kidneys and nerves causing severe complications such as: blocking of the airway damage to the heart muscle (myocarditis) ... There is currently no medication to treat acute Hepatitis B and those with chronic Hepatitis B need to be monitored regularly ...

https://en.wikipedia.org/wiki/Childhood_immunizations_in_the_United_States

... an acute abdomen) with inflammation of the inner abdominal (peritoneal) surface due, for example, to appendicitis or ... kidney, ureter, bladder) could reveal nephrolithiasis and bowel gas pattern Symptomatic relief may be provided by paracentesis ... Volvulus Zoster Skin lesions may not be visible until another day or two Abdominal migraine Abdominal wall strain/injury ...

https://en.wikipedia.org/wiki/Abdominal_guarding

... with acute tubular necrosis plays a critical role in determining disease severity and outcomes for acute kidney injury. ... Acute renal failure, now referred to as acute kidney injury, is a common and clinically important problem. Acute kidney injury ... Acute tubular necrosis (ATN) is the most common cause of acute kidney injury in both native and transplant kidneys. ... Acute renal failure, now referred to as acute kidney injury (AKI), is a common and clinically important problem, affecting ...

https://www.medscape.com/viewarticle/762699

Sixteen cases of acute kidney injury following exposure to SCs were identified in six states with illness onset during March 16 ... Acute Kidney Injury Associated with Synthetic Cannabinoid Use - Multiple States, 2012. In March 2012, the Wyoming Department of ... Results of toxicologic analysis of implicated products and/or clinical specimens from seven patients with acute kidney injury ... Chronic kidney disease after kidney injury: a systemic review and meta-analysis. Kid Int 2012;81:442-8. ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6206a1.htm

Acute kidney injury after cardiac surgery in eastern Saudi Arabia Alkhunaizi, A.M.; Shah, S.S.A.; Wesslen, U.S.; Al Sadah, Z. ... Acute kidney injury is a serious complication after cardiac surgery. This study was conducted to determine the frequency of ... acute kidney injury and the associated risk factors following cardiac surgery at Dhahran health ... ... Epidemiology of acute renal failure in hospitalized patients: experience from southern Saudi Arabia ...

https://extranet.who.int/iris/restricted/browse?authority=Acute+Kidney+Injury&type=mesh

Overview of Acute Kidney Injury in Pregnancy. Acute kidney injury (AKI) is not common in pregnancy, and kidney injury requiring ... Rao S, Jim B. Acute Kidney Injury in Pregnancy: The Changing Landscape for the 21st Century. Kidney Int Rep. 2018 Mar. 3 (2): ... Kidney Injury in Late Pregnancy. Although the most important causes of kidney injury in late pregnancy are preeclampsia and the ... Disorders that cause acute kidney injury in early or late pregnancy generally fall into very different categories. It must also ...

https://emedicine.medscape.com/article/246123-overview

Plasmodium vivax Malaria-associated Acute Kidney Injury, India, 2010-2011 Vivek B. Kute. , Hargovind L. Trivedi, Aruna V. ... Comparison of 25 Plasmodium vivax patients with acute kidney injury, Ahmedabad, India, 2010-2011* ... Plasmodium vivax Malaria-associated Acute Kidney Injury, India, 2010-2011. ... APACHE, Acute Physiology and Chronic Health Evaluation; SOFA ,Sequential Organ Failure Assessment; MODS, Multiple Organ ...

https://wwwnc.cdc.gov/eid/article/18/5/11-1442-t2

... which used to be called acute renal failure, is the sudden decrease in kidney function. When acute kidney injury occurs, the ... Acute kidney injury, which used to be called acute renal failure, is the sudden decrease in kidney function. When acute kidney ... The most common causes of acute kidney injury are serious infection, blood loss from major surgery or injury, or medicines such ... This will continue until the kidneys are functioning normally. Most people who develop acute kidney injury are already in the ...

https://www.healthlinkbc.ca/acute-kidney-injury

Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int. 2012 Mar;81(5):442-8. http ... Keywords: acute kidney injury, adverse drug effect, community hospital, kidney function, Saudi Arabia ... Acute kidney injury (AKI) is a major public health concern and is associated with high morbidity, mortality and healthcare ... Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015 Aug; ...

https://www.emro.who.int/ar/emhj-volume-26-2020/volume-26-issue-8/in-hospital-acute-kidney-injury.html

... injury to kidney, failure of kidney function, loss of kidney function, and end-stage renal failure (RIFLE) classification ... The Acute Kidney Injury Network (AKIN) group has recently proposed modifications to the risk of renal failure, ... The Acute Kidney Injury Network (AKIN) group has recently proposed modifications to the risk of renal failure, injury to kidney ... Acute kidney injury classification: comparison of AKIN and RIFLE criteria Shock. 2010 Mar;33(3):247-52. doi: 10.1097/SHK. ...

https://pubmed.ncbi.nlm.nih.gov/19543147/?dopt=Abstract

Thomas NHS Foundation Hospital in London, UK, who covered the evaluation and management of acute kidney injury in patients ... br />
Curriculum Topic: Fluids, Electrolytes, and Acute Kidney Injury ... COVID-19 Rapid Resource Center > COVID Associated Acute Kidney Injury (AKI) COVID Associated Acute Kidney Injury (AKI). Dr. ... Thomas NHS Foundation Hospital in London, UK, who covered the evaluation and management of acute kidney injury in patients ...

https://sccm.org/COVID19RapidResources/Resources/COVID-Associated-Acute-Kidney-Injury-

Acute Kidney Injuries occur for a variety of reasons, including infections, illnesses, surgeries, or the adverse effects of ... Patients may suffer Acute Kidney Injury (AKI) for a variety of reasons. Some have kidney injury with infections, surgeries, or ...

https://www.nuh.com.sg/Health-Information/Diseases-Conditions/Pages/Acute-Kidney-Injury.aspx

... is associated with acute kidney injury (AKI), according to a new study that will be presented at ASN Kidney Week 2015, held Nov ... is associated with acute kidney injury (AKI), according to a new study that will be presented at ASN Kidney Week 2015, held Nov ... is associated with acute kidney injury (AKI), according to a new study that will be presented at ASN Kidney Week 2015, held Nov ... Study: "Tenofovir Nephrotoxicity is an Important Cause of Acute Kidney Injury in HIV Infected Inpatients" (Abstract FR-PO481) ...

https://www.infectioncontroltoday.com/view/tenofovir-linked-acute-kidney-injury-hiv-infected-patients

Background: Acute Kidney Injury (AKI) is a common clinical complication. Plasma/serum neutrophil gelatinase-associated ... Genetic predisposition to acute kidney injury in critically ill adults. Laura Vilander, Helsingin yliopisto. ... Methods: Kidney transplantation (n = 28) served as a clinical model of renal ischaemic injury. We used ELISA to measure NGAL ... Ischaemic proximal and distal tubular damage occurs in kidney transplantation without concomitant NGAL washout from the kidney ...

https://helda.helsinki.fi/browse?value=Acute%20Kidney%20Injury&type=subject

Researching ways to improve the care of patients and reduce their risk of acute kidney injury (AKI) following surgery. ... Some of these contents can cause problems for the kidney and result in acute kidney injury (AKI). Approximately 20-30% of ... She is looking to improve the care of patients and reduce their risk of acute kidney injury (AKI) following surgery. ... They will treat kidney cells in a dish with blood from different patients. Looking at how the kidney cells respond to the ...

https://www.kidneyresearchuk.org/2022/07/21/predicting-acute-kidney-injury-risk-post-surgery/

In preparation for RAI, he underwent thyroid hormone withdrawal (THW) associated with acute kidney injury (AKI), as marked by a ... acute hypothyroidism is unknown, which has possible implications for thyroid cancer patients preparing to receive radioactive ... future studies should address the role of recombinant TSH to mitigate deleterious renal effects of acute hypothyroidism in this ... hormone replacement may attenuate decline in renal function and improve cardiovascular outcomes in patients with chronic kidney ...

https://www.hindawi.com/journals/crie/2015/932372/

Distant organ injury following acute kidney injury. American Journal of Physiology - Renal Physiology. 2007 Jul;293(1):F28-F29 ... Awad, Alaa S. ; Okusa, Mark D. / Distant organ injury following acute kidney injury. In: American Journal of Physiology - Renal ... Awad, A. S., & Okusa, M. D. (2007). Distant organ injury following acute kidney injury. American Journal of Physiology - Renal ... Awad, AS & Okusa, MD 2007, Distant organ injury following acute kidney injury, American Journal of Physiology - Renal ...

https://pennstate.pure.elsevier.com/en/publications/distant-organ-injury-following-acute-kidney-injury

... are associated with pediatric acute kidney injury (AKI). ... NSAIDs Increase Risk of Pediatric Acute Kidney Injury Stephan ... are associated with pediatric acute kidney injury (AKI), according to a study presented at Kidney Week 2012. ... Close more info about NSAIDs Increase Risk of Pediatric Acute Kidney Injury ... Close more info about NSAIDs Increase Risk of Pediatric Acute Kidney Injury ...

https://www.renalandurologynews.com/home/conference-highlights/kidney-week-annual-meeting/kidney-week-2012/kidney-week-2012-general-news/nsaids-increase-risk-of-pediatric-acute-kidney-injury/

Acute kidney injury is commonly associated with sepsis, cardiovascular collapse, congestive heart failure, major surgery, ... Acute kidney injury. In: Taal MW, Chertow GM, Marsden PA, et al, eds. Brenner and Rectors the kidney. 9th ed. Philadelphia, PA ... Acute kidney injury. In: Taal MW, Chertow GM, Marsden PA, et al, eds. Brenner and Rectors the kidney. 9th ed. Philadelphia, PA ... Acute kidney injury. In: Taal MW, Chertow GM, Marsden PA, et al, eds. Brenner and Rectors the kidney. 9th ed. Philadelphia, PA ...

https://bestpractice.bmj.com/topics/en-us/83/history-exam

Effective September 21: UNC Medical Center Inpatient Visitor Restrictions Visiting hours 9 a.m. - 9 p.m. Adult inpatients will be allowed 1 visitor during the day (9 a.m. - 9 p.m.) and 1 visitor at night (9 p.m. - 9 a.m.) COVID-19 positive patients will continue to have no visitors (except for laboring women, who… Read More →. ...

https://www.mombaby.org/resources/nicu-acute-kidney-injury/

Recurrent Acute Kidney Injury Following Bath Salts Intoxication. *. Adedotun Adebamiro, MD, PhD Adedotun Adebamiro ... Bath salts intoxication should be included on the list of substances that can cause acute kidney injury and other metabolic ... We report a case of recurrent acute kidney injury associated with repeated bath salts intoxication. The patient, who presented ... Rasburicase improves hyperuricemia in patients with acute kidney injury secondary to rhabdomyolysis caused by ecstasy ...

https://www.ajkd.org/article/S0272-6386%2811%2901507-1/fulltext

L-loss of kidney function, E-end stage kidney disease) and Acute Kidney Injury Network criteria, and serum and urine AKI ... Recent studies on the dose of dialysis in AKI are reviewed.Keywords: acute kidney injury, biomarkers, interleukin-18 ... Acute kidney injury (AKI) is an independent risk factor for morbidity and mortality. This review provides essential information ... The review also focuses on recent studies on the diagnosis of AKI using the RIFLE (R-renal risk, I-injury, F-failure, ...

https://www.dovepress.com/article_metric.php?article_id=5395

Indonesia has temporarily suspended the circulation of all liquid medicines after 99 children died of acute kidney injury, ... Recently, about 70 children in Gambia died from acute kidney injury, which were allegedly related to the diethylene glycol and ... Indonesia temporarily suspends liquid medicines after 99 kids die of acute kidney injury. ... Indonesia has temporarily suspended the circulation of all liquid medicines after 99 children died of acute kidney injury, ...

https://www.glamsham.com/world/health-lifestyle/indonesia-temporarily-suspends-liquid-medicines-after-99-kids-die-of-acute-kidney-injury

... Acute Kidney Injury (AKI), ... previously called acute renal failure, occurs when kidney function deteriorates rapidly over hours or days and elevated levels ... It is increasingly recognised that a diagnosis of AKI may in the long-term lead to a higher risk of kidney failure or death. ... have assembled a team of investigators from the University of Limerick and University College Dublin with expertise in kidney ...

https://www.hrb.ie/funding/approved-awards/awards-approved/award/acute-kidney-injury-aki-in-the-irish-health-system-incidence-severity-and-clinical-consequences/

The VA/NIH Acute Renal Failure Trial Network: Intensity of renal support in critically ill patients with acute kidney injury. N ... Weekend Hospital Admission, Acute Kidney Injury, and Mortality. Matthew T. James, Ron Wald, Chaim M. Bell, Marcello Tonelli, ... Weekend Hospital Admission, Acute Kidney Injury, and Mortality. Matthew T. James, Ron Wald, Chaim M. Bell, Marcello Tonelli, ... because admissions for acute kidney injury (AKI) were not distinguished from those for chronic kidney disease (CKD), some ...

https://jasn.asnjournals.org/content/21/5/845?ijkey=41d64ad2ab5c4da2c53156345f11a5f4d4c4ead0&keytype2=tf_ipsecsha

Here, we present a series of patients who developed Herpes labialis after Russells viper bite and had acute kidney injury. We ... snake bite with acute kidney injury admitted in our department and snake bite was the most common cause of acute kidney injury. ... in patients with Russells viper bite-induced acute kidney injury to that of patients with other causes of acute kidney injury ... Diagnosis of acute kidney injury was made as per RIFLE criteria; 10 cases of Herpes labialis were noted during this period. ...

https://www.ajtmh.org/view/journals/tpmd/84/6/article-p1016.xml?rskey=QzvBcf&result=1

Almost 100 children in Indonesia have died from acute kidney ... ... Indonesia says 99 children have died from acute kidney injury ... JAKARTA (Reuters) - Almost 100 children in Indonesia have died from acute kidney injury this year, a health ministry official ...

https://www.saltwire.com/nova-scotia/news/indonesia-says-99-children-have-died-from-acute-kidney-injury-this-year-100785017/

Acute kidney injury (AKI) is a devastating clinical condition affecting at least two-thirds of critically ill patients, and, ... We have determined that, after injury, F4/80hi-expressing kidney-resident macrophages (KRMs) are a distinct cellular ... These data indicate that mechanisms involved in kidney development may be functioning after injury in KRMs. ... This MHCII- KRM phenotype reappears after injury. RNA sequencing shows that injury causes transcriptional reprogramming of KRMs ...

https://insight.jci.org/articles/view/125503/ga

Derivation and external validation of a risk index for predicting acute kidney injury requiring kidney replacement therapy ... Importance - Severe acute kidney injury (AKI) is a serious postoperative complication. A tool for predicting the risk of AKI ... Main Outcomes and Measures - Acute kidney injury requiring KRT within 14 days after surgery. Discrimination was assessed using ... requiring kidney replacement therapy (KRT) after major noncardiac surgery might assist with patient counseling and targeted use ...

https://www.ices.on.ca/Publications/Journal-Articles/2021/August/Derivation-and-external-validation-of-a-risk-index-for-predicting-acute-kidney-injury

Acute Kidney Injury in Patients Operated On for Type A Acute Aortic Dissection: Incidence, Risk Factors and Short-Term Outcomes ... preoperative Cystatin-C level and mechanical ventilation times were independent risk factors for acute kidney injury after ... present a retrospective single-center study on 712 patients with acute type A dissection who underwent repair utilizing ...

https://www.ctsnet.org/jans/acute-kidney-injury-patients-operated-type-acute-aortic-dissection-incidence-risk-factors-and

... and serum albumin affected the incidence of postcontrast acute kidney injury. The incidence of postcontrast acute kidney injury ... acute kidney injury. ED. emergency department. eGFR. estimated glomerular filtration rate. PC-AKI. postcontrast acute kidney ... Contrast-Induced Acute Kidney Injury in Radiologic Management of Acute Ischemic Stroke in the Emergency Setting. J.W. Myung, J. ... Contrast-Induced Acute Kidney Injury in Radiologic Management of Acute Ischemic Stroke in the Emergency Setting ...

http://www.ajnr.org/content/41/4/632.abstract

Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. Kidney Int 81: 477-485, ... Acute kidney injury risk assessment at the hospital front door: What is the best measure of risk? Clin Kidney J 8: 673-680, ... Raising awareness of acute kidney injury: A global perspective of a silent killer. Kidney Int 84: 457-467, 2013pmid:23636171. ... Acute Kidney Injury in the Era of the AKI E-Alert. Jennifer Holmes, Timothy Rainer, John Geen, Gethin Roberts, Kate May, Nick ...

https://cjasn.asnjournals.org/content/11/12/2123.long

Bagshaw, SM, George, C & Bellomo, R 2008, ' A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients ', Nephrology Dialysis Transplantation , vol. 23, no. 5, pp. 1569 - 1574. (monash.edu)
A key objective of the Nephrology Sister Centre Programme between the renal units in Cardiff and Addis Ababa, sponsored by the International Society of Nephrology, is to facilitate development of the local clinical service in Ethiopia specifically focused on the management of acute kidney injury (AKI). (samj.org.za)
Acute Kidney Injury is a common complication of sepsis in ICU patients," said John A. Kellum, MD, Professor and Vice Chair Department of Critical Care Medicine and Director, Center for Critical Care Nephrology at University of Pittsburgh. (am-pharma.com)

In September 2022, the FDA approved terlipressin to improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney function. (medscape.com)
Waterloos M (2022) Causing Hydroureteronephrosis and Acute Kidney Injury. (scitechnol.com)

In addition to the high mortality, hospital-acquired AKI is associated with high resource utilization, prolonged hospitalization, prolonged mechanical ventilation, and development of chronic kidney disease (CKD) (5). (who.int)
The association between renal dysfunction and hypothyroidism is of increasing clinical importance as thyroid hormone replacement may attenuate decline in renal function and improve cardiovascular outcomes in patients with chronic kidney disease (CKD). (hindawi.com)
Renal insufficiency and hypothyroidism are common conditions that may share a mechanistic relationship, as the prevalence of hypothyroidism among those with chronic kidney disease (CKD) is increased [ 1 ]. (hindawi.com)
Advanced age is associated with chronic kidney disease, underlying renal vascular disease, and other comorbid medical conditions that predispose to AKI. (bmj.com)
Risks increase with increasing severity of chronic kidney disease. (bmj.com)
AKI incidence rates of 9% to 38% have been reported in patients with diabetes and chronic kidney disease undergoing contrast exposure. (bmj.com)
In preparation, we have assembled a team of investigators from the University of Limerick and University College Dublin with expertise in kidney disease, epidemiology, statistics, and information systems. (hrb.ie)
1 However, because admissions for acute kidney injury (AKI) were not distinguished from those for chronic kidney disease (CKD), some speculated that this association was in fact driven by admissions of patients with ESRD. (asnjournals.org)
Age, chronic kidney disease, medication (nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, β blockers, statins, and insulin) use following contrast media exposure, and serum albumin affected the incidence of postcontrast acute kidney injury. (ajnr.org)
On the basis of a presumption that early identification may help raise standards of care and improve patient outcomes, an automated real-time e-alert system for AKI on the basis of the Kidney Disease Improving Global Outcomes (KDIGO) change in creatinine diagnostic criteria has been established and implemented nationally across all areas of the National Health Service in Wales. (asnjournals.org)
The ELAIN trial was a single centre study recruiting 231 ICU patients with stage 2 AKI, based on the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines (Table 1 ) [ 11 ]. (biomedcentral.com)
Background Kidney damage is associated with increased workload in high ambient temperatures, and may represent a pathway to chronic kidney disease of unknown origin in agricultural workers. (cdc.gov)
Summary: This review summarizes the roles of the KP and its metabolites in acute kidney injury (AKI) and chronic kidney disease (CKD) based on current literature evidence. (nus.edu.sg)
We included patients admitted with sepsis and acute kidney injury during the first 48 h from admission to intensive care (according to Kidney Disease Improving Global Outcome criteria). (lu.se)
and End-stage kidney disease.Table 1. (medscape.com)
Acute kidney injury (AKI) commonly occurs in coronavirus disease 2019 (COVID-19) patients who have been hospitalised and is associated with a poor prognosis . (bvsalud.org)
It can also lead to chronic kidney disease (CKD), more costs and longer hospital stay. (biomedcentral.com)
Dr. Heyka's specialty interests include chronic and acute renal failure, dialysis, hypertension, renal bone disease, cardiovascular disease in kidney patients, and vascular access for dialysis. (clevelandclinic.org)
Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
I've learned a lot about this disease and the number of people seeking a kidney transplant. (nkfi.org)
Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD), atherosclerosis and diabetic kidney disease (DKD). (portlandpress.com)
Furthermore, there is increasing evidence that ROS, inflammation and fibrosis promote each other and are part of a vicious connection leading to development and progression of CVD and kidney disease in diabetes. (portlandpress.com)
Traditional topics considered for inclusion in the surveillance system cover areas of chronic kidney disease that are widely accepted and of direct relevance to public health based upon peer-reviewed research published over time. (cdc.gov)
The section on emerging topics is designed to bring to light recent advances in chronic kidney disease relevant to public health surveillance of CKD. (cdc.gov)
While it currently focuses on risk factors - both modifiable and non-modifiable, it is intended in the future to include other topics that provide novel insights into the burden of kidney disease, its geographic distribution and temporal trends, advances in processes of care (both diagnostic and therapeutic), and newer insights into awareness of CKD, associated health outcomes or health system capacity. (cdc.gov)
Chronic Kidney Disease Surveillance System-United States. (cdc.gov)
Critically ill patients are at a heightened risk of experiencing acute respiratory disease syndrome, septic shock, multi-organ failure, kidney or cardiac injury. (who.int)
The Changing Trajectory of Diabetic Kidney Disease A group of diverse agents have the ability to reduce the progression of diabetic kidney disease. (medscape.com)
Post-transplant HBV Reactivation With Kidneys With Resolved HBV Is it safe to transplant kidneys from persons with resolved HBV into HBV naive recipients with end-stage renal disease? (medscape.com)
Prevalence of NAFLD in Patients With Chronic Kidney Disease How common is NAFLD among CKD patients? (medscape.com)
Nova Max Creatinine/eGFR is an important new tool to improve kidney care through detection of kidney disease early enough to successfully treat the disease. (novabiomedical.com)
60 ml/min/1.73m2 are considered to have kidney disease. (novabiomedical.com)
This is the preferred method for estimation of glomerular filtration rate because of better accuracy at detecting early stages of kidney disease. (novabiomedical.com)
6 The Nova creatinine eGFR meter was used to evaluate patients that were asymptomatic for CKD but were either on potentially nephrotoxic medications or at risk for chronic kidney disease. (novabiomedical.com)
60 (the level indicating kidney disease). (novabiomedical.com)
The kidneys of deceased HIV-positive donors can be safely transplanted into people living with HIV who have end-stage kidney disease, investigators report in the American Journal of Transplantation . (aidsmap.com)
An increasing number of people living with HIV have end-stage kidney disease and are in need of a kidney transplant. (aidsmap.com)
PPI use has also been linked to an increased risk of Acute Kidney Injury (AKI or Acute Renal Failure) and Chronic Kidney Disease. (beasleyallen.com)
Lawyers in our firm's Mass Torts Section are currently investigating cases involving PPI use and AIN, AKI or Acute Renal Failure, and Chronic Kidney Disease. (beasleyallen.com)
The unique form of Modified Citrus Pectin developed by Dr. Eliaz is recognized as the only commercially available galectin-3 blocker, substantiated by more than 75+ published studies in cancer, cardiovascular disease, chronic kidney disease, and other pro-inflammatory, degenerative conditions. (dreliaz.org)
The presence of CVD, chronic kidney disease, prolonged prothrombin time and elevated lactate dehydrogenase (LDH) were associated with mortality. (who.int)
Mortality from COVID-19 was associated with having CVD, chronic kidney disease, elevated LDH and prolonged prothrombin time. (who.int)
Acute kidney injury (AKI) is a common clinical syndrome and an independent risk factor of chronic kidney disease and end-stage renal failure. (proteomtech.com)
Our blog brings you voices from the fight against kidney disease - patients, their loved ones, renal professionals, and many others. (kidneyfund.org)
Highlights of a very successful year in state advocacy for AKF and our community of kidney disease advocates. (kidneyfund.org)
AKF works on behalf of the 37 million Americans living with kidney disease, and the millions more at risk, to support people wherever they are in their fight against kidney disease - from prevention through post-transplant living. (kidneyfund.org)
It appears that NSAID use may be safe in healthy individuals without any underlying chronic kidney disease. (sportsmedreview.com)
NSAID use appears to promote progression of chronic kidney disease. (sportsmedreview.com)
NSAID use in patients with other comorbidities can contribute to CKD progression or the development of kidney disease. (sportsmedreview.com)
Only tests on a kidney from an affected dog, most likely post mortem, will give 100% confirmation of the disease,' added David. (nottinghampost.com)

issue 16, pages 1725-1739) discuss the involvement of TLR2 and TLR4 in autophagy associated with cisplatin-induced acute kidney injury. (portlandpress.com)

Dr. Marlies Ostermann from Guy's & St. Thomas' NHS Foundation Hospital in London, UK, who covered the evaluation and management of acute kidney injury in patients with COVID-19, including a review of the COVID ADQI Work Group AKI consensus report. (sccm.org)
Weisbord SD, Palevsky PM. Prevention and management of acute kidney injury. (medlineplus.gov)

Studies dating back to the 1990s have linked PPIs, including Nexium, Prevacid, and Prilosec, to kidney problems, including Acute Interstitial Nephritis (AIN), which is inflammation in the spaces between the kidney tubules. (beasleyallen.com)
Acute interstitial nephritis is inflammation of the interstitium or space between the renal tubules. (sportsmedreview.com)

Acute kidney injury frequently occurs as a result of acute tubular necrosis (ATN), which is often caused by a reduction in systemic blood pressure or renal blood flow (e.g., as observed in severe sepsis or during renal transplantation). (medscape.com)
[ 1-3 ] A number of pathologies cause AKI, the most common of which is acute tubular necrosis (ATN). (medscape.com)
Histological changes in acute tubular necrosis. (medscape.com)
Typical changes in acute tubular necrosis include flattening of tubular epithelial cells and loss of tubular cell nuclei. (medscape.com)
Clinical studies of immunotherapy in acute tubular necrosis. (medscape.com)
Conclusions: Ischaemic proximal and distal tubular damage occurs in kidney transplantation without concomitant NGAL washout from the kidney graft into blood. (helsinki.fi)
Supports prerenal azotemia that may progress to acute tubular necrosis. (bmj.com)
Hepatitis E virus (HEV) infection, a common cause of acute infectious hepatitis with acute cholestasis, has been associated with renal manifestations such as acute tubular necrosis (ATN) and glomerulonephritis, but the current literature is scant on acute HEV infection causing cholemic nephrosis with AKI. (indianjnephrol.org)
Ultrasound-guided renal biopsy was performed which revealed normal appearing glomeruli with evidence of diffuse acute tubular injury, and over 50% of all tubules had intraluminal bile casts, which was confirmed with Fouchet's stain [Figure 1] . (indianjnephrol.org)
[1] Conventionally, the diagnosis is made with the coexistence of diffuse tubular injury along with tubular intraluminal bile casts. (indianjnephrol.org)
The pathogenesis has not been fully elucidated yet, but direct tubular toxicity from bilirubin and bile salts and tubular intraluminal obstruction (such as which happens in myeloma kidney) are the two proposed mechanisms. (indianjnephrol.org)
Acute tubular necrosis and pre-renal acute kidney injury: utility of urine microscopy in their evaluation - a systematic review. (biomedcentral.com)
Pathophysiology of septic acute kidney injury: a different view of tubular injury. (biomedcentral.com)
Cyclooxygenase enzymes, which regulate the conversion of arachidonic acid to prostaglandins, are abundantly present in the kidneys and play an important role in renal hemostasis, renin release, renal tubular salt and water reabsorption. (sportsmedreview.com)
Acute tubular necrosis occurs from death of the epithelial cells in the renal tubules. (sportsmedreview.com)

abstract = "Background: The pathophysiology of septic acute kidney injury is inadequately understood. (lu.se)

AKI in native kidneys is associated with significant morbidity and mortality, with 20-40% mortality in the first year postdiagnosis in those patients requiring renal support. (medscape.com)
Despite advances in health care, morbidity and mortality associated with acute renal failure [‎ARF]‎ remain high. (who.int)
Hospital-acquired acute kidney injury is associated with increased mortality and has major public health implications. (who.int)
Acute kidney injury (AKI) is a major public health concern and is associated with high morbidity, mortality and healthcare costs. (who.int)
Admission to the hospital on weekends is associated with increased mortality for several acute illnesses. (asnjournals.org)
We sought to determine if admission to hospital on the weekend with a diagnosis of AKI was associated with higher in-hospital mortality than admission on a weekday using nationally representative data from U.S. acute care, nonfederal hospitals between 2003 and 2006. (asnjournals.org)
Acute kidney injury (AKI) is a devastating clinical condition affecting at least two-thirds of critically ill patients, and, among these patients, it is associated with a greater than 60% risk of mortality. (jci.org)
Furthermore, acute kidney injury was associated with increased short-term mortality. (ctsnet.org)
Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the administration of iodinated contrast media (CM) for diagnostic and interventional cardiovascular procedures and is associated with substantial morbidity and mortality. (eurekamag.com)
Professor Peter Pickkers, MD PhD, Chair of Experimental Intensive Care Medicine, Radboud University Medical Center, and principal investigator of the STOP-AKI study said: "Acute Kidney Injury affects millions of patients each year and comes with a substantial risk of mortality. (am-pharma.com)
Acute Kidney Injury involves inflammatory processes in the kidney which can lead to complete loss of renal function and is associated with high mortality rates. (am-pharma.com)
Acute kidney injury (AKI) has high morbidity and mortality in intensive care units (ICU). (biomedcentral.com)
Acute kidney injury (AKI) is a major cause of morbidity and mortality. (sportsmedreview.com)

When acute kidney injury occurs, the kidneys have trouble removing waste products and excess fluids, which then build up in the body and upset the body's normal chemical balance. (healthlinkbc.ca)
Acute Kidney Injury (AKI), previously called acute renal failure, occurs when kidney function deteriorates rapidly over hours or days and elevated levels of waste products accumulate in the blood. (hrb.ie)
This is particularly true for HRS-acute kidney injury (AKI), which rarely occurs spontaneously and may be associated with spontaneous bacterial peritonitis (SBP) in 25% of cases. (medscape.com)
Acute kidney failure occurs in about three to seven percent of the 37 million yearly admissions to United States hospitals, or about 1 to 2.6 million people. (medicap.com)
It usually occurs in three settings: Loss of blood flow to the kidneys (blood loss, low blood pressure from heart failure, hardening of the renal arteries and blood clots), damage to the kidney tissue (from medications, infections, poisons), and obstruction of urine flow (enlarged prostate, urinary stones, bladder cancers, obstruction of the urethra). (medicap.com)
This usually occurs when direct injury or impact affects the body's kidneys. (medicap.com)
When acute kidney failure occurs, the kidneys are suddenly unable to filter the blood of unnecessary wastes and therefore becomes unable to maintain the body's fluid and electrolyte balance. (medicap.com)
A build up of wastes occurs as the kidneys are unable to push them out into the bladder to be disposed of through urination. (medicap.com)

Acute kidney injury, which used to be called acute renal failure, is the sudden decrease in kidney function. (healthlinkbc.ca)
Acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products-measured by blood urea nitrogen (BUN) and serum creatinine levels-over the course of hours to weeks. (medscape.com)

30 mL/min/1.73 m 2 showed a higher incidence of acute kidney injury. (ajnr.org)
IMSEAR at SEARO: Incidence of Acute Kidney Injury in Hospitalized Children. (who.int)
Evaluation of heat stress and cumulative incidence of acute kidney injury in sugarcane workers in Guatemala. (cdc.gov)

Main Outcomes and Measures - Acute kidney injury requiring KRT within 14 days after surgery. (ices.on.ca)
Conclusions: In this post hoc analysis, we identified two subphenotypes of septic acute kidney injury with different clinical outcomes. (lu.se)
Sepsis -induced acute kidney injury (AKI) continues to be associated with poor outcomes in critical care patients . (bvsalud.org)
Clinical Trajectories and Impact After AKI in the ICU What do we know about the clinical trajectories and outcomes of patients with ICU-acquired acute kidney injury? (medscape.com)
Outcomes were every bit as good as those observed in people with HIV whose kidney donor was HIV negative. (aidsmap.com)
We report the first results of HIV-positive donor to HIV-positive recipient kidney transplantation in the United States, and directly compare outcomes in HIV-positive recipients of HIV-negative donor kidneys to evaluable attributable risk of HIV-positive donors," write the authors. (aidsmap.com)
Dr Christine Durand and her co-investigators from the Hope in Action project wanted to get a clearer understanding of outcomes among individuals with HIV who received a kidney of an HIV-positive donor. (aidsmap.com)
They also wished to expand the existing research base by comparing these outcomes with those of HIV-positive kidney transplant patients who had an HIV-negative donor. (aidsmap.com)

Further elucidation of the KP may hold promise for the development of biomarkers and targeted therapies for these kidney diseases. (nus.edu.sg)
AM‐Pharma B.V., a biopharmaceutical company focused on the development of recombinant human Alkaline Phosphatase (recAP) for inflammatory diseases, today announced positive results from its adaptive Phase II study in 301 sepsis patients with Acute Kidney Injury (AKI), the largest therapeutic study in AKI to date. (am-pharma.com)

Contact your provider if your urine output slows or stops or you have other symptoms of acute kidney failure. (medlineplus.gov)
Symptoms of acute kidney failure can hit suddenly and should not be ignored. (medicap.com)
However, some symptoms of acute kidney failure can be mistaken for other milder conditions such as the common flu, so if you begin to experience symptoms, make sure to visit your doctor so you can get the correct diagnosis. (medicap.com)

In 2002, the Acute Dialysis Quality Initiative (ADQI) was created with the primary goal of developing consensus and evidence-based guidelines for the treatment and prevention of acute kidney injury (AKI). (medscape.com)
New insights into the diagnosis, treatment and prevention of acute otitis media (AOM) have been gained in recent years. (bvsalud.org)
In recent years, new information has been acquired regarding the diagnosis, treatment and prevention of acute otitis media (AOM). (bvsalud.org)

KRMs after injury are also enriched in Wingless-type MMTV integration site family (Wnt) signaling, indicating that a pathway vital for mouse and human kidney development is active. (jci.org)
Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway. (bvsalud.org)
We are devising an acute reversal pathway to kind of implement it into practice. (pharmacytimes.com)

Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads to vascular and renal injury in diabetes. (portlandpress.com)

The optimal timing of renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI) has been much debated. (biomedcentral.com)
Acute kidney injury (AKI) is one of the most common complications in critically ill patients in intensive care units (ICU). (biomedcentral.com)

Lab analysis confirmed "unacceptable" amounts of diethylene glycol and ethylene glycol, which can be toxic and lead to acute kidney injury, the WHO said. (cnn.com)
The WHO this week said laboratory analysis of four Maiden products - Promethazine Oral Solution, Kofexmalin Baby Cough Syrup, Makoff Baby Cough Syrup and Magrip N Cold Syrup - had confirmed 'unacceptable' amounts of diethylene glycol and ethylene glycol, which can be toxic and lead to acute kidney injury. (reuters.com)

Patients who reached the primary outcome and were age 14 years or older were accepted into the AKI group (489 patients) and were excluded if they used to have a kidney transplant or were receiving RRT. (biomedcentral.com)
I got a kidney transplant for Christmas! (nkfi.org)
Donor Kidney Transplants From SARS-CoV-2 Positive Donors Could SARS-CoV-2 positive donor kidneys be safely considered for transplant? (medscape.com)
Issues Regarding COVID-19 in Kidney Transplantation The emergence of the COVID-19 Omicron variant has raised questions regarding the management of kidney transplant recipients. (medscape.com)

Rationale: Measured at intensive care unit admission (ICU), the predictive value of neutrophil gelatinase-associated lipocalin (NGAL) for severe acute kidney injury (AKI) is unclear. (eur.nl)
Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population. (biomedcentral.com)

Previously, the US Food and Drug Administration granted Fast Track designation to recAP for the treatment of sepsis-associated acute kidney injury. (am-pharma.com)

Acute Dialysis Quality Initiative Work Group , 2004 . (ajtmh.org)

The incidence of postcontrast acute kidney injury was determined using the baseline estimated glomerular filtration rate. (ajnr.org)
The value of the baseline estimated glomerular filtration rate at which the occurrence of postcontrast acute kidney injury increased was also determined. (ajnr.org)
Acute kidney injury (AKI) is a pathological condition characterized by a rapid decrease in glomerular filtration rate and nitrogenous waste accumulation during hemodynamic regulation. (ijbs.com)

Pyelonephritis Kidney: pyelonephritis . (vetlexicon.com)

A study to assess RIFLE urine output criteria based on creatinine concentrations for the development of contrast-induced acute kidney injury (CA-AKI) in intensive care (ICU) patients found low predictive value. (medscape.com)
Intravenous sodium bicarbonate is not superior to intravenous sodium chloride for reducing the risk for death or contrast-induced acute kidney injury (AKI) in patients who are at risk for renal complications and are undergoing angiography , according to a randomized trial published in the New England Journal of Medicine . (thecardiologyadvisor.com)
Previous models for contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI) include procedure-related variables in addition to pre-procedural variables. (ajconline.org)

A kidney can come from a deceased donor. (nkfi.org)
But, we each have two kidneys and you only need one, so a living donor can give the ultimate gift, the gift of life. (nkfi.org)
The study involved 75 people with HIV who received a kidney from a deceased donor between 2016 and 2019. (aidsmap.com)

Importance - Severe acute kidney injury (AKI) is a serious postoperative complication. (ices.on.ca)

However, NGAL is not kidney-specific. (helsinki.fi)
We used ELISA to measure NGAL concentrations at 2 minutes after kidney graft reperfusion in simultaneously taken samples of renal arterial and renal venous blood. (helsinki.fi)

Acute kidney injury is a serious complication after cardiac surgery. (who.int)

Even though the drug was withdrawn in all cases, 37 percent of the patients needed hemodialysis and 58 percent did not completely recover their kidney function. (infectioncontroltoday.com)
For people with kidney failure who use home hemodialysis, this. (kidneyfund.org)

The Acute Kidney Injury Network (AKIN) group has recently proposed modifications to the risk of renal failure, injury to kidney, failure of kidney function, loss of kidney function, and end-stage renal failure (RIFLE) classification system. (nih.gov)
Acute kidney injury is the sudden and temporary loss of kidney function. (medicap.com)

Acute renal failure, now referred to as acute kidney injury, is a common and clinically important problem. (medscape.com)
Acute renal failure, now referred to as acute kidney injury (AKI), is a common and clinically important problem, affecting between 5 and 10% of all hospitalized patients, and 30-40% of those admitted to a critical care setting. (medscape.com)
Ecstasy-induced rhabdomyolysis and its role in the development of acute renal failure. (ajkd.org)
It is increasingly recognised that a diagnosis of AKI may in the long-term lead to a higher risk of kidney failure or death. (hrb.ie)
Design, Setting, and Participants - In this prognostic study, 5 risk prediction models were derived and internally validated in a population-based cohort of adults without preexisting kidney failure who underwent noncardiac surgery in Alberta, Canada, between January 1, 2004, and December 31, 2013. (ices.on.ca)
The best performing model and corresponding risk index were externally validated in a population-based cohort of adults without preexisting kidney failure who underwent noncardiac surgery in Ontario, Canada, between January 1, 2007, and December 31, 2017. (ices.on.ca)
Failure to identify these risk factors represents a lost opportunity to identify patients at high risk of developing renal injury who would benefit from renal function monitoring. (samj.org.za)
The primary outcome measure was occurrence of AKI based on Risk-Injury-Failure (RIFLE) classification during the first week of ICU stay. (eur.nl)
failure is present in such cases even if the increase in SCr is less than 3-fold, provided that the new SCr is greater than 4 mg/dL (350 μmol/L) and results from an acute increase of at least 0.5 mg/dL (44 μmol/L). (medscape.com)
Acute kidney failure is the rapid (less than 2 days) loss of your kidneys' ability to remove waste and help balance fluids and electrolytes in your body. (medlineplus.gov)
Other blood tests may be done to find the underlying cause of kidney failure. (medlineplus.gov)
Sir, Cholemic nephrosis (also known as bile cast nephropathy) is an underreported cause of acute kidney injury (AKI) and is usually seen in patients with sustained cholestasis, such as those with advanced cirrhosis or acute on chronic liver failure (ACLF). (indianjnephrol.org)
Plaintiffs claim the companies should be held accountable for their failure to warn consumers about the drug's potential to cause kidney damage. (beasleyallen.com)
A systematic review of urinary findings in experimental septic acute renal failure. (biomedcentral.com)
Acute renal failure Kidney: acute kidney injury (AKI) . (vetlexicon.com)
Recent studies have shown that the incidence of acute kidney failure is increasing in hospitals and patient populations in the United States, likely due to more elderly and more ill patients. (medicap.com)
Acute kidney failure is a rapid loss the kidneys' ability to filter the blood and maintain the body's fluid and electrolyte balance. (medicap.com)
It is a medical emergency that can result in chronic kidney failure or death if left untreated. (medicap.com)
Symptoms can be sudden, and are dependent on the type of kidney failure occurring. (medicap.com)
If you are experiencing symptoms that are associated with acute kidney failure, talk to your doctor right away. (medicap.com)
The cause of acute kidney failure comes from acute kidney injury or AKI. (medicap.com)
Losing a lot of blood can cause sudden kidney failure as well as certain drugs or poisons. (medicap.com)

acute kidney injury is a serious complication in hospitalized patients. (who.int)
Background: Acute Kidney Injury (AKI) is a common clinical complication. (helsinki.fi)

A 56-year-old, Caucasian male with history of uncontrolled hypertension, obesity, and congenital absence of the left kidney presented with submandibular mass. (hindawi.com)

CK may be measured to evaluate myopathy and to monitor patients with rhabdomyolysis for acute kidney injury. (mayocliniclabs.com)

She is looking to improve the care of patients and reduce their risk of acute kidney injury (AKI) following surgery. (kidneyresearchuk.org)
A tool for predicting the risk of AKI requiring kidney replacement therapy (KRT) after major noncardiac surgery might assist with patient counseling and targeted use of measures to reduce this risk. (ices.on.ca)
Within their cohort, preoperative Cystatin-C level and mechanical ventilation times were independent risk factors for acute kidney injury after aortic surgery. (ctsnet.org)
The care of acute kidney injury (AKI) in critically ill children shares several features with adult AKI with some critical distinctions: in both settings, however, the exact identification of renal dysfunction, in-depth knowledge of disparate risk factors and patient-specific management are the primary targets in order to provide optimal care. (elsevier.com)
SAN DIEGO (Reuters Health) Jan 21 - Current guidelines from the American College of Surgeons severely underestimate the risk of mild to moderate postoperative acute kidney injury (AKI), according to research presented this week at the 2011 annual Critical Care Congress of the Society of Critical Care Medicine. (medscape.com)
Defining acute kidney injury as a postoperative change in serum creatinine that is 2 mg/dL or more over baseline, as stated by current ACS NSQIP guidelines, severely underestimates the risk of mild and moderate acute kidney injury in the postoperative period. (medscape.com)
Cite this: Guidelines Underestimate Risk of Post-Op Acute Kidney Injury: Study - Medscape - Jan 21, 2011. (medscape.com)
Kidney injury risk during prolonged exposure to current and projected wet bulb temperatures occurring during extreme heat events in healthy young men. (cdc.gov)
Wet bulb temperatures (Twet) during extreme heat events are commonly 31 degrees C. Recent predictions indicate that Twet will approach or exceed 34 degrees C. Epidemiological data indicate that exposure to extreme heat events increases kidney injury risk. (cdc.gov)
The primary outcome was the product of IGFBP7 and TIMP-2 [IGFBP7·TIMP-2], which provided an index of kidney injury risk. (cdc.gov)
Pregnancy After Living Kidney Donation Pregnancy after living kidney donation could lead to an increased risk of complications. (medscape.com)

Furthermore, the long-term outcome following ATN in both native and transplanted kidneys is also variable, with some patients recovering renal function completely while others develop renal scarring, which is associated with chronic renal dysfunction. (medscape.com)
Objective: To determine the incidence and outcome of acute kidney injury (AKI) in hospitalized patients. (who.int)

Acute kidney injury (AKI) was defined by a change in serum creatinine of ≥0.3mg/dL or ≥1.5 times the pre-shift creatinine over the course of the work shift. (cdc.gov)
The ACS National Surgical Quality Improvement Program (ACS NSQIP) defines post-op acute kidney injury as a rise in serum creatinine of at least 2 mg/dL. (medscape.com)
Dr. Azra Bihorac told attendees at the conference that she and her colleagues used two different definitions of acute kidney injury: the acute kidney injury network (AKIN) classification (i.e., a post-op serum creatinine rise of at least 0.3 mg/dL) and the ACS-NSQIP definition (i.e., 2 mg/dL or more). (medscape.com)
Injury, based on serum creatinine or urinary volume criteria. (who.int)

I suffered an acute kidney injury in 2018. (nkfi.org)

Full recovery of renal function was observed in 39% and 44% in the drug induced and non-drug induced acute kidney injury groups, respectively. (who.int)
Despite consistent epidemiologic evidence, the nature of this association is not completely understood due to complexities in thyroid function interpretation in the setting of uremia and the subtleties of interaction between direct (e.g., reduced thyroid hormone signaling at the level of the nephron) and indirect (e.g., systemic hemodynamic alterations) consequences of hypothyroidism on the kidney [ 1 , 2 ]. (hindawi.com)
This study aimed to identify the incidence of postcontrast acute kidney injury using baseline renal function when CTA and cerebral angiography were performed sequentially. (ajnr.org)
Patients with low baseline renal function had the highest incidence of postcontrast acute kidney injury after CTA and cerebral angiography, but no fatal adverse effects were documented. (ajnr.org)
Acute kidney injury (AKI) is a clinical syndrome manifested by a rapid or abrupt decline in kidney function and subsequent dysregulation of the body electrolytes and volume, and abnormal retention of nitrogenous waste. (medscape.com)
The significant improvements demonstrated in survival and kidney function are very encouraging and strongly support further development of recAP. (am-pharma.com)
While the addition of recAP to the standard of care did not affect kidney function in the first week of the study (the primary endpoint), it did show a significant, progressive and sustained improvement in renal function over the 28-day study period. (am-pharma.com)
Acute Kidney Injury (AKI) involves inflammatory processes in the kidney which can lead to complete loss of renal function. (am-pharma.com)
In adults with normal liver and kidney function, the terminal half-life of propylene glycol ranges from 1.4 hours to 3.3 hours (Speth et al. (cdc.gov)
We observed that THC not only increased the survival rate , improved the kidney function and ameliorated the renal histological damage of septic mice , but also inhibited inflammatory response, prohibited oxidative stress , and prevented cell apoptosis in renal tissues in septic mice . (bvsalud.org)
Nova Max is a fast, accurate and easy to use meter and biosensor for kidney function testing. (novabiomedical.com)
His kidney function was grossly deranged with a urea and creatinine level of 197 mg/dl and 5.6 mg/dl, respectively. (indianjnephrol.org)
These cause sudden drops in kidney function. (medicap.com)

Kidney mononuclear phagocytes (MPs) are implicated in pathogenesis and healing in mouse models of AKI and, thus, have been the subject of investigation as potential targets for clinical intervention. (jci.org)
Role and mechanism of non-coding RNA in the pathogenesis of acute kidney injury. (proteomtech.com)

The most common causes of acute kidney injury are serious infection, blood loss from major surgery or injury, or medicines such as non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, or the dyes (contrast agents) used in X-ray tests. (healthlinkbc.ca)
SAN DIEGO-Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with pediatric acute kidney injury (AKI) , according to a study presented at Kidney Week 2012. (renalandurologynews.com)
Increased levels of inflammatory and endothelial injury markers characterized subphenotype 2. (lu.se)

Ethylene glycol is a potent cause of acute toxicity in humans. (cdc.gov)

With the broader AKIN definition, 27% had acute kidney injury. (medscape.com)
In September 2004, the Acute Kidney Injury Network (AKIN) was formed. (medscape.com)

Results: In total, 301 patients with septic acute kidney injury were included. (lu.se)

Using the Nationwide Inpatient Sample, a large database of admissions to acute care, nonfederal hospitals in the United States, we identified 963,730 admissions with a diagnosis of AKI between 2003 and 2006. (asnjournals.org)
During a 4-year period, we identified 963,730 admissions with a diagnosis of AKI within acute care, nonfederal U.S. hospitals. (asnjournals.org)
A diagnosis of cholemic nephrosis causing nonoliguric AKI, likely resulting from acute HEV infection, was made. (indianjnephrol.org)
She is admitted with a tentative diagnosis of acute kidney injury (AKI). (nursing-assignment-help.com)

Genetic predisposition to acute kidney injury in critically ill adults. (helsinki.fi)
This guideline covers preventing, detecting and managing acute kidney injury in children, young people and adults. (bvsalud.org)

present a retrospective single-center study on 712 patients with acute type A dissection who underwent repair utilizing hypothermic circulatory arrest. (ctsnet.org)

To determine the incidence of in-hospital acute kidney injury in Eastern Saudi Arabia. (who.int)

During acute HIV infection, HIV is highly infectious because the virus is multiplying at a very rapid rate. (aidsmap.com)
Cholemic nephrosis from acute hepatitis E Virus infection: A forgotten entity? (indianjnephrol.org)
Nayak S, Sharma M, Kataria A, Tiwari S C, Rastogi A, Mukund A. Cholemic nephrosis from acute hepatitis E Virus infection: A forgotten entity? (indianjnephrol.org)

A kidney or abdominal ultrasound is the preferred test for diagnosing a blockage in the urinary tract. (medlineplus.gov)

Anatomy8

Organisms6

Diseases51

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes14

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science6

Health Care28

Acute renal failure caused by nephrotoxins. (1/3360)

Sodium reabsorption and distribution of Na+/K+-ATPase during postischemic injury to the renal allograft. (2/3360)

Endothelin up-regulation and localization following renal ischemia and reperfusion. (3/3360)

Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application. (4/3360)

Abysmal prognosis of patients with type 2 diabetes entering dialysis. (5/3360)

Treatment of malarial acute renal failure by hemodialysis. (6/3360)

Intranephron distribution and regulation of endothelin-converting enzyme-1 in cyclosporin A-induced acute renal failure in rats. (7/3360)

Prevalence and clinical outcome associated with preexisting malnutrition in acute renal failure: a prospective cohort study. (8/3360)

Acute Kidney Injury

Lipocalins

Kidney

Renal Replacement Therapy

Creatinine

Acute-Phase Proteins

Azotemia

Kidney Diseases

Reperfusion Injury

Critical Illness

Kidney Tubular Necrosis, Acute

Kidney Function Tests

Biological Markers

Rhabdomyolysis

Kidney Tubules

Wounds and Injuries

Cystatin C

Oliguria

Intensive Care Units

Glomerular Filtration Rate

Sepsis

Kidney Tubules, Proximal

Cardiac Surgical Procedures

Blood Urea Nitrogen

Urinalysis

Renal Dialysis

Risk Factors

Time Factors

Retrospective Studies

Hospital Mortality

Prospective Studies

Crush Syndrome

Fluid Therapy

Cardiopulmonary Bypass

Kidney Transplantation

Brain Injuries

Contrast Media

Early Diagnosis

Severity of Illness Index

Kidney Failure, Chronic

Nephrology

Treatment Outcome

Interleukin-18

Acute Disease

Anuria

Disease Models, Animal

Ischemia

Renal Insufficiency, Chronic

Preoperative Period

Acute Lung Injury

Thrombotic Microangiopathies

Kidney Cortex Necrosis

Risk Assessment

Postoperative Complications

Intensive Care

Athletic Injuries

Incidence

Hemofiltration

Predictive Value of Tests

Mice, Inbred C57BL

Multiple Organ Failure

Spinal Cord Injuries

Uromodulin

Proto-Oncogene Proteins

Prognosis

Cardio-Renal Syndrome

Length of Stay

Kidney Cortex

Cohort Studies

Rats, Sprague-Dawley

Renal Circulation

Nephritis

Renal Insufficiency

Immune System Processes

Hemodiafiltration

ROC Curve

Logistic Models

APACHE

Kidney Glomerulus

Proteinuria