AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceHealth Care
Acute Kidney InjuryLipocalinsKidneyRenal Replacement TherapyCreatinineAcute-Phase ProteinsAzotemiaKidney DiseasesReperfusion InjuryCritical IllnessKidney Tubular Necrosis, AcuteKidney Function TestsBiological MarkersRhabdomyolysisKidney TubulesWounds and InjuriesCystatin COliguriaIntensive Care UnitsGlomerular Filtration RateSepsisKidney Tubules, ProximalCardiac Surgical ProceduresBlood Urea NitrogenUrinalysisRenal DialysisRisk FactorsTime FactorsRetrospective StudiesHospital MortalityProspective StudiesCrush SyndromeFluid TherapyCardiopulmonary BypassKidney TransplantationBrain InjuriesContrast MediaEarly DiagnosisSeverity of Illness IndexKidney Failure, ChronicNephrologyTreatment OutcomeInterleukin-18Acute DiseaseAnuriaDisease Models, AnimalIschemiaRenal Insufficiency, ChronicPreoperative PeriodAcute Lung InjuryThrombotic MicroangiopathiesKidney Cortex NecrosisRisk AssessmentPostoperative ComplicationsIntensive CareAthletic InjuriesIncidenceHemofiltrationPredictive Value of TestsMice, Inbred C57BLMultiple Organ FailureSpinal Cord InjuriesUromodulinProto-Oncogene ProteinsPrognosisCardio-Renal SyndromeLength of StayKidney CortexCohort StudiesRats, Sprague-DawleyRenal CirculationNephritisRenal InsufficiencyImmune System ProcessesHemodiafiltrationROC CurveLogistic ModelsAPACHEKidney GlomerulusProteinuriaCritical CareIothalamate MeglumineSodium BicarbonateReceptors, VirusNephrectomyNephritis, InterstitialApoptosisIodine CompoundsBurnsPatient Outcome AssessmentInjury Severity ScoreSnake BitesDelayed Graft FunctionCisplatinLeg InjuriesKidney MedullaDiureticsSurvival RateLung InjuryNeutrophil Infiltration
Acute Kidney Injury
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Lipocalins
A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Renal Replacement Therapy
Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys.
Creatinine
Acute-Phase Proteins
Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
Azotemia
A biochemical abnormality referring to an elevation of BLOOD UREA NITROGEN and CREATININE. Azotemia can be produced by KIDNEY DISEASES or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed UREMIA.
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues.
Reperfusion Injury
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Critical Illness
A disease or state in which death is possible or imminent.
Kidney Tubular Necrosis, Acute
Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
Kidney Function Tests
Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Rhabdomyolysis
Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
Kidney Tubules
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Wounds and Injuries
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Cystatin C
An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.
Oliguria
Decreased URINE output that is below the normal range. Oliguria can be defined as urine output of less than or equal to 0.5 or 1 ml/kg/hr depending on the age.
Intensive Care Units
Hospital units providing continuous surveillance and care to acutely ill patients.
Glomerular Filtration Rate
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Kidney Tubules, Proximal
The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.
Cardiac Surgical Procedures
Surgery performed on the heart.
Blood Urea Nitrogen
The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Urinalysis
Examination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.
Renal Dialysis
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Risk Factors
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Hospital Mortality
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Prospective Studies
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Crush Syndrome
Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.
Fluid Therapy
Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.
Cardiopulmonary Bypass
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Kidney Transplantation
The transference of a kidney from one human or animal to another.
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Contrast Media
Substances used to allow enhanced visualization of tissues.
Early Diagnosis
Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.
Severity of Illness Index
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Nephrology
A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Interleukin-18
A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
Acute Disease
Disease having a short and relatively severe course.
Anuria
Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Ischemia
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Renal Insufficiency, Chronic
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Preoperative Period
The period before a surgical operation.
Acute Lung Injury
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Thrombotic Microangiopathies
Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.
Kidney Cortex Necrosis
Death of cells in the KIDNEY CORTEX, a common final result of various renal injuries including HYPOXIA; ISCHEMIA; and drug toxicity.
Risk Assessment
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Intensive Care
Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.
Athletic Injuries
Injuries incurred during participation in competitive or non-competitive sports.
Incidence
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Hemofiltration
Extracorporeal ULTRAFILTRATION technique without HEMODIALYSIS for treatment of fluid overload and electrolyte disturbances affecting renal, cardiac, or pulmonary function.
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Mice, Inbred C57BL
Multiple Organ Failure
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
Spinal Cord Injuries
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Uromodulin
A glycosyl-phosphatidyl-inositol (GPI) - anchored membrane protein found on the thick ascending limb of the LOOP OF HENLE. The cleaved form of the protein is found abundantly in URINE.
Proto-Oncogene Proteins
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Prognosis
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Cardio-Renal Syndrome
Condition where a primary dysfunction of either heart or kidney results in failure of the other organ (e.g., HEART FAILURE with worsening RENAL INSUFFICIENCY).
Length of Stay
The period of confinement of a patient to a hospital or other health facility.
Kidney Cortex
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Renal Circulation
The circulation of the BLOOD through the vessels of the KIDNEY.
Nephritis
Inflammation of any part of the KIDNEY.
Renal Insufficiency
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
Immune System Processes
Mechanisms of action and interactions of the components of the IMMUNE SYSTEM.
Hemodiafiltration
The combination of hemodialysis and hemofiltration either simultaneously or sequentially. Convective transport (hemofiltration) may be better for removal of larger molecular weight substances and diffusive transport (hemodialysis) for smaller molecular weight solutes.
ROC Curve
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Logistic Models
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
APACHE
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
Kidney Glomerulus
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
Critical Care
Health care provided to a critically ill patient during a medical emergency or crisis.
Iothalamate Meglumine
A radiopaque medium used for urography, angiography, venography, and myelography. It is highly viscous and binds to plasma proteins.
Sodium Bicarbonate
A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Receptors, Virus
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Nephrectomy
Excision of kidney.
Nephritis, Interstitial
Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Iodine Compounds
Inorganic compounds that contain iodine as an integral part of the molecule.
Burns
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Patient Outcome Assessment
Injury Severity Score
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
Snake Bites
Bites by snakes. Bite by a venomous snake is characterized by stinging pain at the wound puncture. The venom injected at the site of the bite is capable of producing a deleterious effect on the blood or on the nervous system. (Webster's 3d ed; from Dorland, 27th ed, at snake, venomous)
Delayed Graft Function
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Leg Injuries
General or unspecified injuries involving the leg.
Kidney Medulla
The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
Diuretics
Agents that promote the excretion of urine through their effects on kidney function.
Survival Rate
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Lung Injury
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Neutrophil Infiltration
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Tertiary Care Centers
A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Chi-Square Distribution
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Trauma Severity Indices
Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
Russell's Viper
A genus of snakes of the family VIPERIDAE. It is distributed in West Pakistan, most of India, Burma, Ceylon, Thailand, southeast China, Taiwan, and a few islands of Indonesia. It hisses loudly when disturbed and strikes with great force and speed. Very prolific, it gives birth to 20-60 young. This viper is the leading cause of snakebite in India and Burma. (Moore: Poisonous Snakes of the World, 1980, p127)
Acetylglucosaminidase
A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
Recovery of Function
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Iopamidol
A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.
Administration, Intravenous
Delivery of substances through VENIPUNCTURE into the VEINS.
Water-Electrolyte Balance
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
Interleukin-6
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Mice, 129 Strain
Strains of mice arising from a parental inbred stock that was subsequently used to produce substrains of knockout and other mutant mice with targeted mutations.
Hospitalization
The confinement of a patient in a hospital.
Acetylcysteine
The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.
Myoglobinuria
Nephrogenic Fibrosing Dermopathy
A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.
Oxidative Stress
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Thoracic Surgery
A surgical specialty concerned with diagnosis and treatment of disorders of the heart, lungs, and esophagus. Two major types of thoracic surgery are classified as pulmonary and cardiovascular.
Bleaching Agents
Chemicals that are used to oxidize pigments and thus effect whitening.
Models, Animal
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Iatrogenic Disease
Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.
Water-Electrolyte Imbalance
Disturbances in the body's WATER-ELECTROLYTE BALANCE.
Sesame Oil
The refined fixed oil obtained from the seed of one or more cultivated varieties of Sesamum indicum. It is used as a solvent and oleaginous vehicle for drugs and has been used internally as a laxative and externally as a skin softener. It is used also in the manufacture of margarine, soap, and cosmetics. (Dorland, 28th ed & Random House Unabridged Dictionary, 2d ed)
Eye Injuries
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
Urine
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
Shock, Septic
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
Disease Progression
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Kidney Tubules, Distal
The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Multivariate Analysis
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Hyperuricemia
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Endotoxemia
A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Gentamicins
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Terminology as Topic
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Mesenchymal Stem Cell Transplantation
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Triiodobenzoic Acids
Triiodo-substituted derivatives of BENZOIC ACID.
Abortion, Septic
Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characterized by FEVER, uterine tenderness, and foul discharge.
Ureteral Obstruction
Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
Intensive Care Units, Pediatric
Hospital units providing continuous surveillance and care to acutely ill infants and children. Neonates are excluded since INTENSIVE CARE UNITS, NEONATAL is available.
Earthquakes
Sudden slips on a fault, and the resulting ground shaking and radiated seismic energy caused by the slips, or by volcanic or magmatic activity, or other sudden stress changes in the earth. Faults are fractures along which the blocks of EARTH crust on either side have moved relative to one another parallel to the fracture.
Albuminuria
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
Bioartificial Organs
Artificial organs that are composites of biomaterials and cells. The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin.
Urodynamics
The mechanical laws of fluid dynamics as they apply to urine transport.
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Neck Injuries
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
Up-Regulation
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Animals, Outbred Strains
Animals that are generated from breeding two genetically dissimilar strains of the same species.

Acute renal failure caused by nephrotoxins. (1/3360)

Renal micropuncture studies have greatly changed our views on the pathophysiology of acute renal failure caused by nephrotoxins. Formerly, this type of renal insufficiency was attributed to a direct effect of the nephrotoxins on tubule epithelial permeability. According to that theory, glomerular filtration was not greatly diminished, the filtrate formed being absorbed almost quantitatively and nonselectively across damaged tubule epithelium. Studies in a wide variety of rat models have now shown glomerular filtration to be reduced to a level which will inevitably cause renal failure in and of itself. Passive backflow of filtrate across tubular epithelium is either of minor degree or nonexistent even in models where frank tubular necrosis has occurred. This failure of filtration cannot be attributed to tubular obstruction since proximal tubule pressure is distinctly subnormal in most models studied. Instead, filtration failure appears best attributed to intrarenal hemodynamic alterations. While certain facts tend to incriminate the renin-angiotensin system as the cause of the hemodynamic aberrations, others argue to the contrary. The issue is underactive investigation.  (+info)

Sodium reabsorption and distribution of Na+/K+-ATPase during postischemic injury to the renal allograft. (2/3360)

BACKGROUND: A loss of proximal tubule cell polarity is thought to activate tubuloglomerular feedback, thereby contributing to glomerular filtration rate depression in postischemic acute renal failure (ARF). METHODS: We used immunomicroscopy to evaluate the segmental distribution of Na+/K+-ATPase in tubules of recipients of cadaveric renal allografts. Fractional excretion (FE) of sodium and lithium was determined simultaneously. Observations were made on two occasions: one to three hours after graft reperfusion (day 0) and again on post-transplant day 7. An inulin clearance below or above 25 ml/min on day 7 was used to divide subjects into groups with sustained (N = 15) or recovering (N = 16) ARF, respectively. RESULTS: In sustained ARF, the fractional excretion of sodium (FENa) was 40 +/- 6% and 11 +/- 5%, and the fractional excretion of lithium (FELi) was 76 +/- 5% and 70 +/- 2% on days 0 and 7, respectively. Corresponding findings in recovering ARF were 28 +/- 2% and 6 +/- 2% for the FENa and 77 +/- 4% and 55 +/- 3% (P < 0.05 vs. sustained) for FELi. Na+/K+-ATPase distribution in both groups was mainly basolateral in distal straight and convoluted tubule segments and collecting ducts. However, Na+/K+-ATPase was poorly retained in the basolateral membrane of proximal convoluted and straight tubule segments in sustained and recovering ARF on both days 0 and 7. CONCLUSIONS: We conclude that loss of proximal tubule cell polarity for Na+/K+-ATPase distribution is associated with enhanced delivery of filtered Na+ to the macula densa for seven days after allograft reperfusion. Whether an ensuing activation of tubuloglomerular feedback is an important cause of glomerular filtration rate depression in this form of ARF remains to be determined.  (+info)

Endothelin up-regulation and localization following renal ischemia and reperfusion. (3/3360)

BACKGROUND: Endothelin (ET), a potent vasoconstrictor, is known to play a role in ischemic acute renal failure. Although preproET-1 (ppET-1) mRNA is known to be up-regulated following ischemia/reperfusion injury, it has not been determined which component of the injury (ischemia or reperfusion) leads to initial gene up-regulation. Likewise, although ET-1 peptide expression has been localized in the normal kidney, its expression pattern in the ischemic kidney has not been determined. Therefore, the purpose of this study was twofold: (a) to determine whether ischemia alone or ischemia plus reperfusion is required for the up-regulation of ppET-1 mRNA to occur, and (b) to localize ET-1 peptide expression following ischemia in the rat kidney to clarify better the role of ET in the pathophysiology of ischemia-induced acute renal failure. METHODS: Male Lewis rats underwent clamping of the right renal vascular pedicle for either 30 minutes of ischemia (group 1), 60 minutes of ischemia (group 2), 30 minutes of ischemia followed by 30 minutes of reperfusion (group 3), or 60 minutes of ischemia followed by three hours of reperfusion (group 4). The contralateral kidney acted as a control. ppET-1 mRNA up-regulation and ET-1 peptide expression were examined using the reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. RESULTS: Reverse transcription-polymerase chain reaction yielded a control (nonischemic) value of 0.6 +/- 0.2 densitometric units (DU) of ppET-1 mRNA in the kidney. Group 1 levels (30 min of ischemia alone) were 1.8 +/- 0.4 DU, a threefold increase (P < 0.05). Group 2 levels (60 min of ischemia alone) increased almost six times above baseline, 3.5 +/- 0.2 DU (P < 0.01), whereas both group 3 and group 4 (ischemia plus reperfusion) did not experience any further significant increases in mRNA levels (1.9 +/- 0.4 DU and 2.8 +/- 0.6 DU, respectively) beyond levels in group 1 or 2 animals subjected to similar ischemic periods. ET-1 peptide expression in the ischemic kidneys was significantly increased over controls and was clearly localized to the endothelium of the peritubular capillary network of the kidney. CONCLUSIONS: Initial ET-1 gene up-regulation in the kidney occurs secondary to ischemia, but reperfusion most likely contributes to sustaining this up-regulation. The marked increase of ET-1 in the peritubular capillary network suggests that ET-induced vasoconstriction may have a pathophysiological role in ischemic acute tubular necrosis.  (+info)

Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application. (4/3360)

Efficient and safe heparin anticoagulation has remained a problem for continuous renal replacement therapies and intermittent hemodialysis for patients with acute renal failure. To make heparin therapy safer for the patient with acute renal failure at high risk of bleeding, we have proposed regional heparinization of the circuit via an immobilized heparinase I filter. This study tested a device based on Taylor-Couette flow and simultaneous separation/reaction for efficacy and safety of heparin removal in a sheep model. Heparinase I was immobilized onto agarose beads via cyanogen bromide activation. The device, referred to as a vortex flow plasmapheretic reactor, consisted of two concentric cylinders, a priming volume of 45 ml, a microporous membrane for plasma separation, and an outer compartment where the immobilized heparinase I was fluidized separately from the blood cells. Manual white cell and platelet counts, hematocrit, total protein, and fibrinogen assays were performed. Heparin levels were indirectly measured via whole-blood recalcification times (WBRTs). The vortex flow plasmapheretic reactor maintained significantly higher heparin levels in the extracorporeal circuit than in the sheep (device inlet WBRTs were 1. 5 times the device outlet WBRTs) with no hemolysis. The reactor treatment did not effect any physiologically significant changes in complete blood cell counts, platelets, and protein levels for up to 2 hr of operation. Furthermore, gross necropsy and histopathology did not show any significant abnormalities in the kidney, liver, heart, brain, and spleen.  (+info)

Abysmal prognosis of patients with type 2 diabetes entering dialysis. (5/3360)

INTRODUCTION: The importance of non-insulin-dependent diabetes mellitus (type II diabetes) as a leading cause of end-stage renal disease is now widely recognized. The purpose of this study was to assess life-prognosis and its predictors in a cohort of patients newly entering dialysis. MATERIAL AND METHODS: Eighty-four consecutive type II diabetes patients (40% of all patients) starting dialysis between 01/01/95 and 31/12/96 were studied retrospectively, focusing on clinical data at inception and life-prognosis after a mean follow-up of 211 days. Patients were divided into three groups, according to onset of renal failure: acute 11% (9/84), chronic 61% (51/84) and acutely aggravated chronic renal failure 28% (25/84). RESULTS: Patients (mean age 67 years) had long-standing diabetes (mean duration approximately 15 years), heavy proteinuria (approximately 3 g/24h) and diabetic retinopathy (67%). The average creatinine clearance (Cockcroft's formula) was 13 ml/min. Cardiovascular diseases were highly prevalent at the start of dialysis: history of myocardial infarction (26%), angina (36%) and acute left ventricular dysfunction (67%). More than 80% of the patients underwent the first session dialysis under emergency conditions, a situation in part related to late referral to the nephrology division (63% for chronic patients). A great majority of the patients were overhydrated when starting dialysis, as evidenced by the average weight loss of 6 kg, during the first month of dialysis, required to reach dry weight. Nearly 64% of the patients presented high blood pressure (> 140/90 mmHg) when starting dialysis despite antihypertensive therapy (mean: 2.3 drugs). The outcome of this type II diabetes population was dramatic: 32% (27/84) died after a mean follow-up of 211 days, mostly from cardiovascular diseases. The rate of recovery of renal function was low in both the acute and the acutely aggravated renal failure group (30% and 24%, respectively). Of note, iatrogenic nephrotoxic agents accounted for renal function impairment in nearly 30% of patients. CONCLUSION: Our observational study illustrates the high burden of cardiovascular diseases contrasting with sub-optimal cardiovascular therapeutic interventions in type II diabetes patients entering dialysis. Factors aggravating renal failure were mainly iatrogenic, and therefore largely avoidable. Late referral generally implied a poor clinical condition at the start of dialysis.  (+info)

Treatment of malarial acute renal failure by hemodialysis. (6/3360)

We studied 112 patients with malarial acute renal failure (ARF) during the period 1991-1997 at Bangkok Hospital for Tropical Diseases (Mahidol University, Bangkok, Thailand). Hemodialysis was performed in 101 (90.2%) of these patients. The mean number of times the patients were hemodialyzed was 6.5 (range = 1-27). Ninety-three (83.0%) patients were oliguric and the remainder were nonoliguric. Patients who had oliguric renal failure required more hemodialyses and had more complications than the nonoliguric patients. The oliguric patients had an eight-fold higher risk of requiring six or more hemodialyses (95% confidence interval = 1.2-53.9, P = 0.0008). The overall mortality rate was 10.7% (12 of 112). Eleven of the patients who died were jaundiced and eight of them had cerebral malaria with a Glasgow Coma Score < or = 8. We conclude that hemodialysis is a useful treatment for oliguric and nonoliguric ARF from severe malaria, particularly when initiated early in the course of the illness.  (+info)

Intranephron distribution and regulation of endothelin-converting enzyme-1 in cyclosporin A-induced acute renal failure in rats. (7/3360)

Endothelin-1 (ET-1) is thought to play a significant role in acute renal failure induced by cyclosporin A (CsA). The cDNA sequence encoding endothelin-converting enzyme-1 (ECE-1), which produces the active form of ET-1 from big ET-1, was recently reported. To elicit the role of ECE-1 in the glomerular and tubular dysfunction induced by CsA, the effects of CsA on mRNA and protein expression of ECE-1 in rat kidney and on mRNA expression of prepro-ET-1 and ET A- and B-type receptors in glomeruli were studied. ECE-1 mRNA was detected in glomeruli and in whole nephron segments. ECE-1 mRNA expression was downregulated in all nephron segments at 24 h after CsA injection. Protein levels were also downregulated in glomeruli and in the outer and inner medulla. CsA rapidly increased prepro-ET-1 mRNA expression in glomeruli at 30 to 60 min after injection; this rapid increase was followed by an increase in plasma ET-1 levels. These increases were followed by decreased expression of ECE-1, ET A-type receptor, and ET B-type receptor mRNA at 6 h after injection, and serum creatinine levels were increased at 24 h after CsA injection. It is suggested that downregulation of glomerular and tubular ECE-1 expression may be caused by increased ET-1 synthesis in CsA-induced acute renal failure.  (+info)

Prevalence and clinical outcome associated with preexisting malnutrition in acute renal failure: a prospective cohort study. (8/3360)

Malnutrition is a frequent finding in hospitalized patients and is associated with an increased risk of subsequent in-hospital morbidity and mortality. Both prevalence and prognostic relevance of preexisting malnutrition in patients referred to nephrology wards for acute renal failure (ARF) are still unknown. This study tests the hypothesis that malnutrition is frequent in such clinical setting, and is associated with excess in-hospital morbidity and mortality. A prospective cohort of 309 patients admitted to a renal intermediate care unit during a 42-mo period with ARF diagnosis was studied. Patients with malnutrition were identified at admission by the Subjective Global Assessment of nutritional status method (SGA); nutritional status was also evaluated by anthropometric, biochemical, and immunologic parameters. Outcome measures included in-hospital mortality and morbidity, and use of health care resources. In-hospital mortality was 39% (120 of 309); renal replacement therapies (hemodialysis or continuous hemofiltration) were performed in 67% of patients (206 of 309); APACHE II score was 23.1+/-8.2 (range, 10 to 52). Severe malnutrition by SGA was found in 42% of patients with ARF; anthropometric, biochemical, and immunologic nutritional indexes were significantly reduced in this group compared with patients with normal nutritional status. Severely malnourished patients, as compared to patients with normal nutritional status, had significantly increased morbidity for sepsis (odds ratio [OR] 2.88; 95% confidence interval [CI], 1.53 to 5.42, P < 0.001), septic shock (OR 4.05; 95% CI, 1.46 to 11.28, P < 0.01), hemorrhage (OR 2.98; 95% CI, 1.45 to 6.13, P < 0.01), intestinal occlusion (OR 5.57; 95% CI, 1.57 to 19.74, P < 0.01), cardiac dysrhythmia (OR 2.29; 95% CI, 1.36 to 3.85, P < 0.01), cardiogenic shock (OR 4.39; 95% CI, 1.83 to 10.55, P < .001), and acute respiratory failure with mechanical ventilation need (OR 3.35; 95% CI, 3.35 to 8.74, P < 0.05). Hospital length of stay was significantly increased (P < 0.01), and the presence of severe malnutrition was associated with a significant increase of in-hospital mortality (OR 7.21; 95% CI, 4.08 to 12.73, P < 0.001). Preexisting malnutrition was a statistically significant, independent predictor of in-hospital mortality at multivariable logistic regression analysis both with comorbidities (OR 2.02; 95% CI, 1.50 to 2.71, P < 0.001), and with comorbidities and complications (OR 2.12; 95% CI, 1.61 to 2.89, P < 0.001). Malnutrition is highly prevalent among ARF patients and increases the likelihood of in-hospital death, complications, and use of health care resources.  (+info)

Comparison of acute kidney injury between open and laparoscopic liver resection: Propensity score analysis. | Physicians...Comparison of acute kidney injury between open and laparoscopic liver resection: Propensity score analysis. | Physicians...
The inflammatory response has been shown to be a major contributor to acute kidney injury. Considering that laparoscopic surgery is beneficial in reducing the inflammatory response, we compared the incidence of postoperative acute kidney injury between laparoscopic liver resection and open liver resection. Among 1173 patients who underwent liver resection surgery, 222 of 926 patients who underwent open liver resection were matched with 222 of 247 patients who underwent laparoscopic liver resection, by using propensity score analysis. The incidence of postoperative acute kidney injury assessed according to the creatinine criteria of the Kidney Disease: Improving Global Outcomes definition was compared between those 1:1 matched groups. A total 77 (6.6%) cases of postoperative acute kidney injury occurred. Before matching, the incidence of acute kidney injury after laparoscopic liver resection was significantly lower than that after open liver resection [1.6% (4/247) vs. 7.9% (73/926), P < 0.001]. ...
https://www.physiciansweekly.com/comparison-of-acute-kidney-injury-between-open-and-laparoscopic-liver-resection-propensity-score-analysis/
AmSECT : Blogs : The effect of 6% hydroxyethyl starch (130/0.4) on acute kidney injury in paediatric cardiac surgery: a...AmSECT : Blogs : The effect of 6% hydroxyethyl starch (130/0.4) on acute kidney injury in paediatric cardiac surgery: a...
Click the title to purchase the article.. Summary:. We have evaluated the effect of a colloid solution on acute kidney injury in paediatric cardiac surgery. A total of 195 patients were ramdomly divided into an hydroxyethyl starch group and a control group. In the starch group, 6% hydroxyethyl starch 130/0.4 (Volulyte®) was used as the primary fluid for volume resuscitation but was limited to 30 ml.kg−1. In the control group, only crystalloid fluid was used during the peri-operative period. The incidence of acute kidney injury, peri-operative transfusion, clinical outcomes and laboratory data were compared. The incidence of acute kidney injury determined by Paediatric Risk, Injury, Failure, Loss, End-stage renal disease (pRIFLE) and Acute Kidney Injury Network (AKIN) criteria were no different between the two groups (starch group 40.8% vs. control group 30.0%; p = 0.150 using pRIFLE; 19.6% vs. 21.1% respectively, p = 0.602 using AKIN). There were no differences in clinical outcomes such as ...
http://www.amsect.org/blog/the-effect-of-6-hydroxyethyl-starch-
Trends in Acute Kidney Injury in Patients With Acute Myocardial Infarction | Physicians Weekly for Medical News, Journals &...Trends in Acute Kidney Injury in Patients With Acute Myocardial Infarction | Physicians Weekly for Medical News, Journals &...
Amin AP, Salisbury AC, McCullough PA, et al. Trends in the incidence of acute kidney injury in patients hospitalized with acute myocardial infarction. Arch Intern Med. 2012;172:246-253. Available at: http://archinte.ama-assn.org/cgi/content/full/172/3/246.. Hsu RK, Hsu C. Acute kidney injury: comment on Trends in the incidence of acute kidney injury in patients hospitalized with acute myocardial infarction. Arch Intern Med. 2012;172:253-254.. Parikh CR, Coca SG, Wang Y, et al. Long-term prognosis of acute kidney injury after acute myocardial infarction. Arch Intern Med. 2008;168:987-995.. Aengus Murphy C, Robb SD, Weir RA, et al. Declining renal function after myocardial infarction predicts poorer long-term outcome. Eur J Cardiovasc Prev Rehabil. 2010;17:181-186.. Chertow GM, Burdick E, Honour M, et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16:3365-3370.. Molitoris BA, Levin A, Warnock DG; et al, Acute Kidney Injury Network ...
https://www.physiciansweekly.com/kidney-injury-in-myocardial-infarction/
Risk factors associated to hospital mortality in patients with acute kidney injury on hemodialysis.Risk factors associated to hospital mortality in patients with acute kidney injury on hemodialysis.
INTRODUCTION: The worldwide incidence of acute kidney injury is 18% and the overall hospital mortality can rise above 50%. In Peru, there are few series about mortality of acute kidney injury in hemodialysis patients. OBJECTIVES: To identify risk factors associated to hospital mortality of acute kidney injury in hemodialysis patients. METHODS: This is a retrospective cohort of patients with acute kidney injury in hemodialysis of Hospital Nacional Edgardo Rebagliati Martins gathered between January 2013 and December 2015. The sample size was 154 patients which allowed a power of 80% and a CI of 95%. ICD-10 codes were used to identify medical records of patients with acute kidney injury (N.17) and hemodialysis (Z.49). The independent variable was oliguria, and the primary outcome was hospital mortality. Poisson regression was used for multivariate analysis. RESULTS: We identified a total of 285 patients; 212 medical records were analyzed and 44 were excluded. Out of the 168 medical records, 129 ...
https://repositorioacademico.upc.edu.pe/handle/10757/622342
Pathophysiology of septic acute kidney injury<...Pathophysiology of septic acute kidney injury<...
TY - JOUR. T1 - Pathophysiology of septic acute kidney injury. AU - MÃ¥rtensson, Johan. AU - Bellomo, Rinaldo. PY - 2016. Y1 - 2016. N2 - Background: Despite increased understanDing of the pathophysiology of septic acute kidney injury (AKI), treatment options are limited, and mortality remains high. Summary: Septic AKI is triggered by pathogen-associated molecular patterns from bacteria and damage-associated molecular patterns released from or exposed on damaged cells. Downstream effects include glomerular and peritubular endothelial dysfunction, downregulation of tubular reabsorptive work, cell-cycle arrest, regulated cell death and destruction of damaged cell organelles. In the laboratory, pharmacological modulation of some of these pathways prevents AKI or enhances recovery from AKI, yet no data exist to support the utility of such AKI therapy in man. However, avoiDing systemic and renal venous congestion, hypotension and fluid overload attenuates AKI in critically ill septic patients. Key ...
https://research.monash.edu/en/publications/pathophysiology-of-septic-acute-kidney-injury
Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective...Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective...
The role of systemic hemodynamics in the pathogenesis of septic acute kidney injury (AKI) has received little attention. The purpose of this study was to investigate the association between systemic hemodynamics and new or persistent of AKI in severe sepsis.A retrospective study between 2006 and 2010 was performed in a surgical ICU in a teaching hospital. AKI was defined as development (new AKI) or persistent AKI during the five days following admission based on the Acute Kidney Injury Network (AKIN) criteria. We studied the association between the following hemodynamic targets within 24 hours of admission and AKI: central venous pressure (CVP), cardiac output (CO), mean arterial pressure (MAP), diastolic arterial pressure (DAP), central venous oxygen saturation (ScvO2) or mixed venous oxygen saturation (SvO2).This study included 137 ICU septic patients. Of these, 69 had new or persistent AKI. AKI patients had a higher Simplified Acute Physiology Score (SAPS II) (57 (46 to 67) vs. 45 (33 to 52), P <
http://profiles.eewoww.com/MarjoleinvanIJzendoorn/collections/350/4218/
Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway |...Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway |...
Honokiol is a low-molecular-weight natural product and has been reported to exhibit anti-inflammatory activity. Our study aimed to investigate the influence of honokiol on sepsis-induced acute kidney injury (AKI) in a mouse model. A cecal ligation and puncture (CLP) surgical operation was performed to establish a sepsis-induced acute kidney injury model in mice. Renal histomorphological analysis was performed with periodic acid-Schiff (PAS) staining. The levels of inflammatory markers in serum were measured by ELISA assay. The mRNA and protein levels were assayed by RT-qPCR and western blotting, respectively. Annexin V-FITC/PI staining was used to evaluate glomerular mesangial cell (GMC) apoptosis. The results revealed that honokiol significantly increased the survival rate in mice undergoing a CLP operation. Inflammatory cytokines, such as TNF-α, IL-6 and IL-1β, were significantly inhibited in honokiol-treated septic mice compared with the CLP group. In addition, honokiol showed the ability to
https://cmbl.biomedcentral.com/articles/10.1186/s11658-019-0142-4/figures/4
Do Statins Reduce the Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography or Percutaneous...Do Statins Reduce the Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography or Percutaneous...
Contrast-induced acute kidney injury (CI-AKI), also known as contrast-induced nephropathy, is a common complication of intra-arterial administration of iodinated radiographic contrast medium (IRCM) that may prolong the duration of hospitalization and increase the risk of death (1,2). CI-AKI is characterized by an increase in serum creatinine beginning within the first 24 h of IRCM exposure and peaking at up to 5 days after exposure. CI-AKI is defined most commonly as a rise in serum creatinine concentration ≥0.5 mg/dl or 25% above baseline assessed 48 to 72 h after exposure to contrast (1,2). More recently, the Acute Kidney Injury Network defined CI-AKI as a rise in serum creatinine of ≥0.3 mg/dl above baseline with oliguria (1).. Patients with chronic kidney disease (CKD) are vulnerable to CI-AKI, particularly in the presence of risk factors such as diabetes mellitus and clinical states associated with decreased renal perfusion (1,2). McCullough (1) proposed a pathophysiologic sequence for ...
http://www.onlinejacc.org/content/63/1/80
Dialysis for acute kidney injury can be safely delayed for many patients - NIHR EvidenceDialysis for acute kidney injury can be safely delayed for many patients - NIHR Evidence
Early dialysis does not improve survival among critically ill patients with acute kidney injury, new research shows. A large multinational trial found that starting dialysis within 12 hours of acute kidney injury was no more effective than watchful waiting with delayed dialysis.. Acute kidney injury means that the kidneys stop working suddenly. It is a common complication in patients in intensive care units. If acute kidney injury is not treated, abnormal levels of salts and chemicals can build up in the body, and this can be fatal.. The usual treatment is dialysis or renal replacement therapy, in which a machine removes waste products from the blood. But there is longstanding debate about the best time to start this treatment.. The STARRT-AKI trial included more than 3000 patients in intensive care who developed acute kidney injury. It compared the two strategies: early dialysis or delayed dialysis with watchful waiting. Researchers found that rates of death were similar, regardless of ...
https://evidence.nihr.ac.uk/alert/acute-kidney-injury-dialysis-safely-delayed/
RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis |...RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis |...
The lack of a standard definition for acute kidney injury has resulted in a large variation in the reported incidence and associated mortality. RIFLE, a newly developed international consensus classification for acute kidney injury, defines three grades of severity - risk (class R), injury (class I) and failure (class F) - but has not yet been evaluated in a clinical series. We performed a retrospective cohort study, in seven intensive care units in a single tertiary care academic center, on 5,383 patients admitted during a one year period (1 July 2000-30 June 2001). Acute kidney injury occurred in 67% of intensive care unit admissions, with maximum RIFLE class R, class I and class F in 12%, 27% and 28%, respectively. Of the 1,510 patients (28%) that reached a level of risk, 840 (56%) progressed. Patients with maximum RIFLE class R, class I and class F had hospital mortality rates of 8.8%, 11.4% and 26.3%, respectively, compared with 5.5% for patients without acute kidney injury. Additionally, acute
https://ccforum.biomedcentral.com/articles/10.1186/cc4915/figures/2
Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury<...Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury<...
TY - JOUR. T1 - Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury. AU - Ko, Gang Jee. AU - Boo, Chang Su. AU - Jo, Sang Kyung. AU - Cho, Won Yong. AU - Kim, Hyoung Kyu. PY - 2008/3/1. Y1 - 2008/3/1. N2 - Background. Ischaemia/reperfusion is a major cause of acute kidney injury and can result in poor long-term graft function. Although most of the patients with acute kidney injury recover their renal function, significant portion of patients suffer from progressive deterioration of renal function. A persistent inflammatory response might be associated with long-term changes following acute ischaemia/reperfusion. Macrophages are known to infiltrate into tubulointersitium in animal models of chronic kidney disease. However, the role of macrophages in long-term changes after ischaemia/reperfusion remains unknown. We aimed to investigate the role of macrophages on the development of tubulointerstitial fibrosis and functional ...
https://koreauniv.pure.elsevier.com/en/publications/macrophages-contribute-to-the-development-of-renal-fibrosis-follo
Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Review, H2 2012...Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Review, H2 2012...
Global Markets Directs, Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Review, H2 2012, provides an overview of the indications therapeutic pipeline. This report provides information on the therapeutic development for Acute Renal Failure (ARF) (Acute Kidney Injury), complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Acute Renal Failure (ARF) (Acute Kidney Injury). Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Review, Half Year is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team.
http://www.sbwire.com/press-releases/acute-renal-failure-arf-acute-kidney-injury-pipeline-review-h2-2012-published-187243.htm
Effect of multiple episodes of Acute Kidney Injury on mortality: an observational study<...Effect of multiple episodes of Acute Kidney Injury on mortality: an observational study<...
TY - JOUR. T1 - Effect of multiple episodes of Acute Kidney Injury on mortality. T2 - an observational study. AU - Walker, Heather. AU - De Souza, Nicosha. AU - Hapca, Simona. AU - Witham, Miles D.. AU - Bell, Samira. PY - 2021/2. Y1 - 2021/2. N2 - Background: Patients who survive an episode of acute kidney injury (AKI) are more likely to have further episodes of AKI. AKI is associated with increased mortality, with a further increase with recurrent episodes. It is not clear whether this is due to AKI or as a result of other patient characteristics. The aim of this study was to establish whether recurrence of AKI is an independent risk factor for mortality, or if excess mortality is explained by other factors.Methods: This observational cohort study included adult people from the Tayside region of Scotland, with an episode of AKI during 1st January 2009 and 31st December 2009. AKI was defined using the creatinine based Kidney Disease Improving Global Outcomes definition. Associations between ...
https://discovery.dundee.ac.uk/en/publications/effect-of-multiple-episodes-of-acute-kidney-injury-on-mortality-a
Acute kidney injury due to tropical infectious diseases and animal venoms: a tale of 2 continents | The George Institute for...Acute kidney injury due to tropical infectious diseases and animal venoms: a tale of 2 continents | The George Institute for...
South and Southeast Asia and Latin American together comprise 46 countries and are home to approximately 40% of the world population. The sociopolitical and economic heterogeneity, tropical climate, and malady transitions characteristic of the region strongly influence disease behavior and health care delivery. Acute kidney injury epidemiology mirrors these inequalities. In addition to hospital-acquired acute kidney injury in tertiary care centers, these countries face a large preventable burden of community-acquired acute kidney injury secondary to tropical infectious diseases or animal venoms, affecting previously healthy young individuals. This article reviews the epidemiology, clinical picture, prevention, risk factors, and pathophysiology of acute kidney injury associated with tropical diseases (malaria, dengue, leptospirosis, scrub typhus, and yellow fever) and animal venom (snakes, bees, caterpillars, spiders, and scorpions) in tropical regions of Asia and Latin America, and discusses the ...
https://www.georgeinstitute.org.in/publications/acute-kidney-injury-due-to-tropical-infectious-diseases-and-animal-venoms-a-tale-of-2
Acute Kidney Failure | RxWikiAcute Kidney Failure | RxWiki
Acute Kidney Failure, Read about Acute Kidney Failure symptoms, causes, diagnosis, and treatment. Also read Acute Kidney Failure articles about how to live with Acute Kidney Failure, and more.
http://www.rxwiki.com/condition/acute-kidney-failure?diagnosis
Acute Kidney Injury AKI Acute kidney failure, renal failure. Patient | PatientAcute Kidney Injury AKI Acute kidney failure, renal failure. Patient | Patient
acute renal failure (ARF); Acute kidney injury (AKI) or acute kidney failure information available. Treat acute kidney injury AKI and problems with kidney functions and renal issues
https://patient.info/doctor/acute-kidney-injury-pro
INCIDENCE, RISK FACTORS AND OUTCOMES OF ACUTE KIDNEY INJURY IN PRETERM NEWBORNS | Journal of Morphological SciencesINCIDENCE, RISK FACTORS AND OUTCOMES OF ACUTE KIDNEY INJURY IN PRETERM NEWBORNS | Journal of Morphological Sciences
Acute kidney injury is a sudden loss of renal function that results in deterioration of the renals ability to excrete urine in sufficient quantity and adequate composition. The aim of the study was to determine the incidence, risk factors and outcomes of acute kidney injury in preterm newborns. The study was conducted at the University Clinic of Pediatrics-Skopje. It was a clinical, epidemiological prospective study. In the period of two years, 40 preterm newborns hospitalized at the Intensive Care Unit (ICU) with documented kidney injury were analyzed. Medical data records of hospitalized preterm infants with kidney injury were processed. The material was statistically analyzed using methods of descriptive statistics. We evaluated 40 preterm newborns with documented acute kidney injury, who at the period of 2 years were treated in the ICU. The prevalence of kidney injury was 6.9%. Most of the involved preterm newborns were male (72%), and born at 32 to 37 weeks with low birth weight (58%). ...
https://jms.mk/jms/article/view/188
Successful treatment of acute renal failure secondary to complicated infective endocarditis by peritoneal dialysis: a case...Successful treatment of acute renal failure secondary to complicated infective endocarditis by peritoneal dialysis: a case...
Infective endocarditis is one of the most common infections among intravenous drug addicts. Its complications can affect many systems, and these can include acute renal failure. There is a scarcity of cases in the literature related to acute renal failure secondary to infective endocarditis treated with peritoneal dialysis. In this paper, the case of a 48-year-old Saudi male is reported, who presented with features suggestive of infective endocarditis and who developed acute kidney injury that was treated successfully with high tidal volume automated peritoneal dialysis. To our knowledge, this is the second report of such an association in the literature. A 48-year-old Saudi gentleman diagnosed to have a glucose-6-phosphate dehydrogenase deficiency and hepatitis C infection for the last 9 years, presented to the emergency department with a history of fever of 2 days duration. On examination: his temperature = 41 °C, there was clubbing of the fingers bilaterally and a pansystolic murmur in the left
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-2773-8
Transplant outcomes using kidneys from high KDPI acute kidney injury donors<...Transplant outcomes using kidneys from high KDPI acute kidney injury donors<...
TY - JOUR. T1 - Transplant outcomes using kidneys from high KDPI acute kidney injury donors. AU - Jadlowiec, Caroline C.. AU - Hanna, Wael A.. AU - Ninan, Jacob. AU - Ryan, Margaret S.. AU - Das, Devika M.. AU - Smith, Maxwell. AU - Khamash, Hasan Ahmad. AU - Mathur, Amit K.. AU - Singer, Andrew. AU - Moss, Adyr. AU - Reddy, Kunam S.. AU - Heilman, Raymond Lackner. N1 - Publisher Copyright: © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. PY - 2021. Y1 - 2021. N2 - Kidney transplant (KT) outcomes from high kidney donor profile index (KDPI ≥85%) donors with acute kidney injury (AKI) remain underreported. KT from 172 high KDPI Acute Kidney Injury Network (AKIN) stage 0-1 donors and 76 high KDPI AKIN stage 2-3 donors from a single center were retrospectively assessed. The AKIN 2-3 cohort had more delayed graft function (71% vs. 37%, p ,.001). At one year, there were no differences in the estimated glomerular filtration rate (44 ± 17 vs. 46 ± 18, p =.42) or fibrosis on protocol ...
https://mayoclinic.pure.elsevier.com/en/publications/transplant-outcomes-using-kidneys-from-high-kdpi-acute-kidney-inj
Risk factors and outcome of acute kidney injury in children admitted to the pediatric intensive care unit | International...Risk factors and outcome of acute kidney injury in children admitted to the pediatric intensive care unit | International...
Background: Acute kidney injury (AKI) is a common and serious complication in children admitted to the Pediatric Intensive Care Unit (PICU). The primary objective of our study was to estimate the incidence of AKI in children admitted to PICU. Secondary objective was to study the etiology ,short term outcome and determine the predictors of fatality in children with AKI. Methods: This was a prospective, cross sectional study conducted in children aged 1month to 18 years in the Pediatric Intensive Care Unit of Amrita Institute Of Medical Science, Kochi from Nov 2015 to Oct 2017 based on Acute Kidney Injury Network Criteria(AKIN). Results: The incidence of AKI was 18% .59.3% of the AKI patients were ≤5year of age. Most common cause for AKI was due to infections(87%) mainly sepsis(42.7%). 88.9% children had pre renal, 9.3% had renal and 1.9% had post renal type of AKI.40.7% were in stage 1,13% in stage2 and 46.3% in stage 3 based on AKIN criteria. 42.6% had complete recovery, 16.7% had partial ...
http://journalcra.com/article/risk-factors-and-outcome-acute-kidney-injury-children-admitted-pediatric-intensive-care-unit
Contrast-induced acute kidney injury/contrast-induced nephropathy may be related to additional risk factors [Anatol J Cardiol]Contrast-induced acute kidney injury/contrast-induced nephropathy may be related to additional risk factors [Anatol J Cardiol]
Hilmi Umut nal, Yal n Ba aran, Hadim Ako lu. Contrast-induced acute kidney injury/contrast-induced nephropathy may be related to additional risk factors. Anatol J Cardiol. 2018; 19(2): 155- ...
http://anatoljcardiol.com/jvi.aspx?pdir=anatoljcardiol&plng=eng&un=AJC-66915
Influence of hyperuricemia treatment on postoperative acute kidney injury among hyperuricemia patients: a single-center...Influence of hyperuricemia treatment on postoperative acute kidney injury among hyperuricemia patients: a single-center...
Hyperuricemia has been reported to be associated with the development of postoperative acute kidney injury (pAKI). However, it remains underdetermined whether hyperuricemia treatment could decrease the potential risk of pAKI. Here, we investigated this hypothesis among hyperuricemia patients with previously normal renal function by performing a retrospective database analysis. The study screened 18,169 patients, and were examined preoperative serum creatinine, uric acid, and postoperative serum creatinine. Eight hundred thirty-six patients were finally analyzed for the study, of whom 232 were in the treatment group and 604 were in the non-treatment control group. After adjustment for multi-covariates including baseline (pre-treatment) serum uric acid (SUA) levels, the incidence of pAKI in the treatment group (9.05%; 95% CI 6.04-12.1%) was significantly lower than that in the control group (14.2%; 95% CI 11.2-17.2%). On the other hand, further adjusting for preoperative SUA levels, there was no
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4783-1
Acute Kidney Injury: Causes, Diagnosis and Treatments - Nova Science PublishersAcute Kidney Injury: Causes, Diagnosis and Treatments - Nova Science Publishers
Acute kidney injury (AKI) is a common condition with significant associated morbidity and mortality. Although impressive progress has been made in the understanding of the molecular and biochemical mechanisms of kidney injury, as well as in the clinical care of patients with AKI, outcomes have remained disturbingly static over the last 40-50 years. This new book presents topical research data in the study of the causes, diagnosis and treatment of acute kidney injury. Topics discussed include classification of AKI; acute renal failure in the newborn; kidney ischemia and reperfusion injury; pandemic H1N1 influenza A infection and AKI; the role of oxidative stress in renal ischemia; biomarkers in acute kidney injury and B2 adrenoceptor therapy in AKI. (Imprint: Nova Biomedical). ...
https://novapublishers.com/shop/acute-kidney-injury-causes-diagnosis-and-treatments/
NGAL expression during cardiopulmonary bypass does not predict severity of postoperative acute kidney injury | BMC Nephrology |...NGAL expression during cardiopulmonary bypass does not predict severity of postoperative acute kidney injury | BMC Nephrology |...
Acute kidney injury after cardiac surgery is a common complication and outcome may be devastating with a mortality-risk of up to 90% [6, 11, 16-19]. According to AKIN classification, changes in serum creatinine concentrations and reduced urine output define acute kidney injury. Therefore, changes of kidney function are detected with substantial delay. Changes of diuresis and/or serum creatinine levels that appear in the postoperative period can be directly ascribed to CPB, but also to various factors, as haemolysis, blood transfusions, volume deficit, haemodynamic instability, systemic inflammatory response (SIRS), or reduction of renal perfusion in the elderly [15, 20]. Nevertheless, early prediction of the occurrence of AKI after surgery is of crucial importance.. NGAL is a multi-potent 25-kDa protein mainly secreted by neutrophils, playing a fundamental role in iron metabolism [21, 22]. Although the dimeric NGAL is also expressed by other organs [23], the monomeric form is expressed by ...
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0479-8
Acute Kidney Injury | Muljibhai Patel Urological HospitalAcute Kidney Injury | Muljibhai Patel Urological Hospital
Acute Kidney Injury (AKI) or Acute renal failure (ARF) is the temporary rapid breakdown of renal (kidney) function that occurs with high levels of uremic toxins (waste products of the bodys metabolism) accumulate in the blood. AKI occurs when the kidneys are unable to excrete (discharge) the daily load of toxins in the urine. Both kidneys are failing when Acute Kidney Injury (AKI) occurs. One normally functioning kidney can maintain adequate blood filtering. AKI affects approximately 1% of patients on admission to the hospital, 2% to 5% during the hospital stay, and 4% to 15% after cardiopulmonary bypass surgery. Based on the amount of urine that is excreted over a 24-hour period, patients with Acute Kidney Injury (AKI) are separated into two groups: Oliguric: patients who excrete less than 500 milliliters per day (, 16 oz/day) Nonoliguric: patients who excrete more than 500 milliliters per day (, 16 oz/day) In nonoliguric patients, the urine is of poor quality (i.e., contains little waste) ...
http://mpuh.org/disease/acute-kidney-injury
Analyses of acute kidney injury biomarkers by ultra-high performance liquid chromatography with mass spectrometry<...Analyses of acute kidney injury biomarkers by ultra-high performance liquid chromatography with mass spectrometry<...
TY - JOUR. T1 - Analyses of acute kidney injury biomarkers by ultra-high performance liquid chromatography with mass spectrometry. AU - ZaAbi, Mohammed Al. AU - Ali, Badreldin H.. AU - ALOthman, Zeid A.. AU - Ali, Imran. PY - 2016/1/1. Y1 - 2016/1/1. N2 - The newly developed acute kidney injury biomarkers are very important for the early and timely detection of kidney diseases. This review contains details of the analyses of several acute kidney injury biomarkers using ultra-high performance liquid chromatography-mass spectrometry in urine and plasma samples. In this review we attempt to discuss some aspects of the types of the biomarkers, patents, sample preparation, and the analyses. Besides, efforts were also made to discuss the possible uses of superficially porous (core-shell) columns in traditional and inexpensive high-performance liquid chromatography instruments. Additionally, the challenges and the future prospects are also highlighted. The present review will be useful for the ...
https://squ.pure.elsevier.com/en/publications/analyses-of-acute-kidney-injury-biomarkers-by-ultra-high-performa-2
The American Journal of Tropical Medicine and Hygiene | Acute Renal Failure Following Snakebite*The American Journal of Tropical Medicine and Hygiene | Acute Renal Failure Following Snakebite*
Abstract Eight patients with acute renal failure following snakebite were studied. Intravascular hemolysis and disseminated intravascular coagulation contributed to the development of acute renal failure in 6 patients. Direct nephrotoxicity causing acute renal failure is postulated in 2 patients, 1 of whom also revealed evidence of mild, disseminated intravascular coagulation. Three patients had histopathological lesions of acute symmetrical cortical necrosis and 3 had acute tubular necrosis. In 1 patient with acute tubular necrosis, in whom direct nephrotoxicity seemed to be responsible for renal failure, the striking histological feature was a uniform debasement and disappearance of tubular epithelium. In 2 patients with a clinical course of acute tubular necrosis, histological lesions could not be documented. All the 5 patients with acute tubular necrosis regained full recovery of renal function, 3 of them with the help of dialysis and 2 with conservative management. None of the 3 patients with acute
http://www.ajtmh.org/content/journals/10.4269/ajtmh.1975.24.692
Efficacy of Oral Hydration in the Prevention of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary...Efficacy of Oral Hydration in the Prevention of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary...
Background: Efficacy of intravenous (IV) volume expansion in preventing contrast-induced acute kidney injury (CI-AKI) is well known. However, the role of oral hydration has not been well established. The aim of this work was to evaluate the efficacy of oral hydration in preventing CI-AKI. Methods: We prospectively randomized 225 patients undergoing coronary angiography and/or percutaneous coronary intervention in either oral hydration or IV hydration groups. Patients who have at least one of the high-risk factors for developing CI-AKI (advanced age, type 2 diabetes mellitus, anemia, hyperuricemia, a history of cardiac failure or systolic dysfunction) were included in the study. All patients had normal renal function or stage 1-2 chronic kidney disease. Patients in the oral hydration group were encouraged to drink unrestricted amounts of fluids freely whereas isotonic saline infusion was performed by the standard protocol in the IV hydration group. Results: CI-AKI occurred in 8/116 patients ...
https://avesis.acibadem.edu.tr/yayin/26f3c1aa-60cd-464c-adbf-ef1402a1fbdd/efficacy-of-oral-hydration-in-the-prevention-of-contrast-induced-acute-kidney-injury-in-patients-undergoing-coronary-angiography-or-intervention
CXCL8 (3-72) K11R/G31P protects against sepsis-induced acute kidney injury via NF-κB and JAK2/STAT3 pathway | Biological...CXCL8 (3-72) K11R/G31P protects against sepsis-induced acute kidney injury via NF-κB and JAK2/STAT3 pathway | Biological...
Acute kidney injury (AKI), which is mainly caused by sepsis, has high morbidity and mortality rates. CXCL8(3-72) K11R/G31P (G31P) can exert therapeutic effect on inflammatory diseases and malignancies. We aimed to investigate the effect and mechanism of G31P on septic AKI. An AKI mouse model was established, and kidney injury was assessed by histological analysis. The contents of serum creatinine (SCr) and blood urea nitrogen (BUN) were measured by commercial kits, whereas neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) were detected by enzyme-linked immunosorbent assay (ELISA) kits. The expressions of CXCL8 in serum and kidney tissues were determined using ELISA and immunohistochemical analysis, respectively. Apoptosis rate of renal tissue was detected by terminal deoxynucleotidyl transfer-mediated dUTP nick end labeling (TUNEL) analysis. The expressions of inflammatory cytokines were measured by quantitative real-time PCR and Western blot, respectively. The
https://biolres.biomedcentral.com/articles/10.1186/s40659-019-0236-5/tables/1
Acute Kidney Injury: A Guide to Diagnosis and Management - American Family PhysicianAcute Kidney Injury: A Guide to Diagnosis and Management - American Family Physician
Acute kidney injury is characterized by abrupt deterioration in kidney function, manifested by an increase in serum creatinine level with or without reduced urine output. The spectrum of injury ranges from mild to advanced, sometimes requiring renal replacement therapy. The diagnostic evaluation can be used to classify acute kidney injury as prerenal, intrinsic renal, or postrenal. The initial workup includes a patient history to identify the use of nephrotoxic medications or systemic illnesses that might cause poor renal perfusion or directly impair renal function. Physical examination should assess intravascular volume status and identify skin rashes indicative of systemic illness. The initial laboratory evaluation should include measurement of serum creatinine level, complete blood count, urinalysis, and fractional excretion of sodium. Ultrasonography of the kidneys should be performed in most patients, particularly in older men, to rule out obstruction. Management of acute kidney injury involves
https://www.aafp.org/afp/2012/1001/p631.html
Risk factors and outcomes stratified by severity of acute kidney injury in malaria<...Risk factors and outcomes stratified by severity of acute kidney injury in malaria<...
TY - JOUR. T1 - Risk factors and outcomes stratified by severity of acute kidney injury in malaria. AU - Saravu, Kavitha. AU - Rishikesh, Kumar. AU - Parikh, Chirag R.. PY - 2014/3/13. Y1 - 2014/3/13. N2 - Severe acute kidney injury (AKI) is known to have prognostic value for in-hospital outcomes in malaria. However, little is known about the association of AKI of lesser severity with malarial risk factors and outcomes - and such a gap is becoming increasingly relevant with the upsurge in the incidence of AKI due to Plasmodium falciparum malaria and Plasmodium vivax malaria over the last decade. We aimed to identify risk factors of AKI in malaria and assessed in-hospital outcomes stratified by severity of AKI. We performed an observational study of 1,191 hospitalized malaria patients enrolled between 2007 and 2011 in a tertiary care academic center in India. Patients were categorized based on peak serum creatinine into one of three groups: no AKI (,1.6 mg/dL), mild AKI (1.6-3.0 mg/dL), and ...
https://manipal.pure.elsevier.com/en/publications/risk-factors-and-outcomes-stratified-by-severity-of-acute-kidney-
Pharmacological interventions for the prevention of contrast-induced acute kidney injury in high-risk adult patients undergoing...Pharmacological interventions for the prevention of contrast-induced acute kidney injury in high-risk adult patients undergoing...
Pharmacological interventions for the prevention of contrast-induced acute kidney injury in high-risk adult patients undergoing coronary angiography: a systematic review and meta-analysis of randomised controlled trials ...
https://openheart.bmj.com/content/6/1/e000864.altmetrics
Prevention of contrast-induced acute kidney injury in patients undergoing cardiovascular procedures-A systematic review and...Prevention of contrast-induced acute kidney injury in patients undergoing cardiovascular procedures-A systematic review and...
TY - JOUR. T1 - Prevention of contrast-induced acute kidney injury in patients undergoing cardiovascular procedures-A systematic review and network meta-Analysis. AU - Navarese, Eliano P.. AU - Gurbel, Paul A.. AU - Andreotti, Felicita. AU - Koøodziejczak, Michalina Marta. AU - Palmer, Suetonia C.. AU - Dias, Sofia. AU - Buffon, Antonino. AU - Kubica, Jacek. AU - Kowalewski, Mariusz. AU - Jadczyk, Tomasz. AU - Laskiewicz, Michaø. AU - Jȩdrzejek, Marek. AU - Brockmeyer, Maximillian. AU - Airoldi, Flavio. AU - Ruospo, Marinella. AU - Servi, Stefano De. AU - Wojakowski, Wojciech. AU - OConnor, Christopher. AU - Strippoli, Giovanni F.M.. N1 - Publisher Copyright: © 2017 Navarese et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.. PY - 2017/2. Y1 - 2017/2. N2 - Background Interventional diagnostic and ...
https://jhu.pure.elsevier.com/en/publications/prevention-of-contrast-induced-acute-kidney-injury-in-patients-un
Ischemic Acute Kidney Injury Perturbs Homeostasis of Serine Enantiomers in the Body Fluid in Mice: Early Detection of Renal...Ischemic Acute Kidney Injury Perturbs Homeostasis of Serine Enantiomers in the Body Fluid in Mice: Early Detection of Renal...
Ischemic Acute Kidney Injury Perturbs Homeostasis of Serine Enantiomers in the Body Fluid in Mice: Early Detection of Renal Dysfunction Using the Ratio of Serine Enantiomers. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jun8/149833844378-Ischemic-Acute-Kidney-Injury-Perturbs-Homeostasis-of-Serine-Enantiomers-in-the-Body-Fluid-in-Mice-Early-Detection-of-Renal-Dysfunction-Using-the-Rati.php
Continuous renal replacement therapy in acute kidney injury (acute renal failure)Continuous renal replacement therapy in acute kidney injury (acute renal failure)
Dialysis may be required in patients with severe acute kidney injury (AKI, acute renal failure [ARF]). Most patients have been treated with hemodialysis, with the dialysis prescription varying in part with the presence or absence of hypercatabolism.
https://www.uptodate.com/contents/continuous-renal-replacement-therapy-in-acute-kidney-injury-acute-renal-failure
Does acute kidney injury from an ultramarathon increase the risk for greater subsequent injury?<...Does acute kidney injury from an ultramarathon increase the risk for greater subsequent injury?<...
TY - JOUR. T1 - Does acute kidney injury from an ultramarathon increase the risk for greater subsequent injury?. AU - Hoffman, Martin D.. AU - Weiss, Robert H. PY - 2016/9/1. Y1 - 2016/9/1. N2 - Objective: Examine whether the acute kidney injury (AKI) commonly observed among ultramarathon participants places the individual at risk for subsequent AKI of worse magnitude. Design: Observational. Setting: Western States Endurance Run. Participants: Race finishers with postrace blood studies. Independent Variable: Acute kidney injury after 1 race. Main Outcome Measures: Extent of AKI in subsequent race. Results: Among 627 finishes in which serum creatinine values were known, 36.2% met risk or injury criterion with this group characterized by having faster finish times, greater body weight loss during the race, and higher postrace serum creatine kinase and urea nitrogen concentrations when compared with those not meeting the criteria. We identified 38 runners who had undergone postrace blood ...
https://ucdavis.pure.elsevier.com/en/publications/does-acute-kidney-injury-from-an-ultramarathon-increase-the-risk-
Rarefaction of peritubular capillaries following ischemic acute renal failure: A potential factor predisposing to progressive...Rarefaction of peritubular capillaries following ischemic acute renal failure: A potential factor predisposing to progressive...
TY - JOUR. T1 - Rarefaction of peritubular capillaries following ischemic acute renal failure. T2 - A potential factor predisposing to progressive nephropathy. AU - Basile, David P.. PY - 2004/1. Y1 - 2004/1. N2 - Purpose of review: Long-term renal complications of acute renal failure have generally not been expected in patients that recover from acute renal failure. However, as the incidence of acute renal failure is rising, the incidence of long-term complications is likely to increase. As a corollary to ischemic acute renal failure, ischemic injury in the setting of transplant is a leading cause of delayed graft function. Unlike acute renal failure in native kidneys, delayed graft function is highly predictive of chronic nephropathy and organ failure. It is generally well accepted that acute reversible injuries mediated by ischemia render grafts susceptible toward future demise. The nature of the susceptibility that is conveyed to grafts following ischemic injury is not well understood. ...
https://indiana.pure.elsevier.com/en/publications/rarefaction-of-peritubular-capillaries-following-ischemic-acute-r
Correction: Hundred top-cited articles focusing on acute kidney injury: a bibliometric analysis | BMJ OpenCorrection: Hundred top-cited articles focusing on acute kidney injury: a bibliometric analysis | BMJ Open
Liu Y-hui, Wang S-qi, Xue J-hua, et al. Hundred top-cited articles focusing on acute kidney injury: a bibliometric analysis. BMJ Open 2016;6:e011630. The published affiliations of the authors in this article were incorrect. The correct affiliations are given below.. Ning Tan, Yuan-hui Liu, Yong Liu, Ji-yan Chen, Peng-cheng He and Ning Tan: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, Guangdong, China;. Sheng-qi Wang: 1Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China; 2Department of Pharmacy, Nanfang Hospital, Southern Medical University, 1038 Guangzhou, China.. Guo-feng Li: Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.. Jin-hua Xue: 1Department of ...
http://bmjopen.bmj.com/content/6/9/e011630corr1
Impact of introducing electronic acute kidney injury alerts in primary care<...Impact of introducing electronic acute kidney injury alerts in primary care<...
TY - JOUR. T1 - Impact of introducing electronic acute kidney injury alerts in primary care. AU - Aiyegbusi, Oshorenua. AU - Witham, Miles. AU - Lim, Michelle. AU - Gauld, Graham. AU - Bell, Samira. PY - 2019/4. Y1 - 2019/4. N2 - Background: Acute kidney injury (AKI) is associated with decreased survival, future risk of chronic kidney disease and longer hospital stays. Electronic alerts (e-alerts) for AKI have been introduced in the UK in order to facilitate earlier detection and improve management. The aim of this study was to establish if e-alerts in primary care were acted on by examining timing of repeat creatinine testing.Methods: The National Health Service England Acute Kidney Injury electronic alert algorithm was introduced in April 2015 across both primary and secondary care in NHS Tayside accompanied by a programme of education. Data from a 12-month period (2012) predating introduction of the e-alerts were compared with a 12-month period following implementation of ealerts for AKI. ...
https://discovery.dundee.ac.uk/en/publications/impact-of-introducing-electronic-acute-kidney-injury-alerts-in-pr
Levaquin / Cipro / Avelox: Small But Significant Increased Risk Of Acute Kidney Injury Among Men According To Recent Study -...Levaquin / Cipro / Avelox: Small But Significant Increased Risk Of Acute Kidney Injury Among Men According To Recent Study -...
In Addition, A Significant Drug-Drug Interaction Between The Concomitant Use Of Fluoroquinolones And Renin-Angiotensin-System Blockers (Posted by Tom Lamb at DrugInjuryWatch.com) An article published by the Canadian Medical Association during June 2013 in its medical journal CMAJ, Risk of acute kidney injury associated with the use of fluoroquinolones, reported on a study that revealed serious renal side effects in some men who used the popular Levaquin, Cipro, or Avelox, i.e., fluoroquinolone class of antibiotics. From the Abstract for this June 2013 CMAJ article: Background: Case reports indicate that the use of fluoroquinolones may lead to acute kidney injury. We studied the association between the use of oral fluoroquinolones and acute kidney injury, and we examined interaction with renin-angiotensin-system blockers. Methods: We formed a nested cohort of men aged 40-85 enrolled in the United States IMS LifeLink Health Plan Claims Database between 2001 and 2011.... to assess the rate ratio (RR) for
http://www.drug-injury.com/druginjurycom/2013/07/avelox-cipro-levaquin-side-effects-acute-kidney-injury-renal-increased-risk-fluoroquinolones-renin-angiotensin-system-blocker.html
How Does Taking Vitamin B3 Helps Treat Acute Kidney Injury?How Does Taking Vitamin B3 Helps Treat Acute Kidney Injury?
There is a potential that taking oral vitamin B3 might not only treat but also prevent acute kidney injuries. Researchers however have come across vitamin B3 as a potential treatment for acute kidney injury. This article highlights how vitamin B3 can treat acute kidney injury.
https://www.epainassist.com/vitamins-and-supplements/how-does-taking-vitamin-b3-helps-treat-acute-kidney-injury
confidence interval Introduction Approximately 30C40% of patients of acute kidney injury AKI) happen in postoperative...confidence interval Introduction Approximately 30C40% of patients of acute kidney injury AKI) happen in postoperative...
Background Acute kidney damage (AKI) following hepatectomy remains understudied in terms of diagnosis, severity, recovery and prognostic value. as the strongest independent predictor of postoperative mortality but did not impact survival. Conclusion AKI is a common complication after hepatectomy for HCC. Although its development is associated with poor short-term outcomes, it does not appear to be predictive of impaired long-term survival. Abbreviations: AKI, acute kidney injury; KDIGO, kidney disease improving global outcomes; HCC, hepatocellular carcinoma; sCr, serum creatinine; RRT, renal replacement therapy; CKI, chronic kidney injury; eGFR, estimated glomerula filtration rate; ICU, intensive care unit; AUROC, area under the receiver operating curve; OS, overall survival; MELD, model for end stage liver disease; OR, odds ratio; CI, confidence interval Introduction Approximately 30C40% of patients of acute kidney injury (AKI) happen in postoperative configurations.1, 2, buy BMS-863233 ...
http://ablkinase.com/tag/confidence-interval-introduction-approximately-30c40-of-patients-of-acute-kidney-injury-aki-happen-in-postoperative-configurations-1/
Effect of Exogenous Albumin on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Off-pump Coronary...Effect of Exogenous Albumin on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Off-pump Coronary...
Authors: Eun-Ho Lee, M.D. et al. Anesthesiology 5 2016, Vol.124, 1001-1011. Background: Hypoalbuminemia may increase the risk of acute kidney injury (AKI). The authors investigated whether the immediate preoperative administration of 20% albumin solution affects the incidence of AKI after off-pump coronary artery bypass surgery.. Methods: In this prospective, single-center, randomized, parallel-arm double-blind trial, 220 patients with preoperative serum albumin levels less than 4.0 g/dl were administered 100, 200, or 300 ml of 20% human albumin according to the preoperative serum albumin level (3.5 to 3.9, 3.0 to 3.4, or less than 3.0 g/dl, respectively) or with an equal volume of saline before surgery. The primary outcome measure was AKI incidence after surgery. Postoperative AKI was defined by maximal AKI Network criteria based on creatinine changes.. Results: Patient characteristics and perioperative data except urine output during surgery were similar between the two groups studied, the ...
http://anesthesiaexperts.com/uncategorized/effect-exogenous-albumin-incidence-postoperative-acute-kidney-injury-patients-undergoing-off-pump-coronary-artery-bypass-surgery-preoperative-albumin-level-4-0-gdl/
The effects of acute kidney injury on long-term renal function and proteinuria in a general hospitalised population.The effects of acute kidney injury on long-term renal function and proteinuria in a general hospitalised population.
BACKGROUND: Acute kidney injury (AKI) is common in hospitalised patients and is associated with adverse long-term consequences. There is an urgent need to understand these sequelae in general hospitalised patients utilising a prospective cohort-based approach. We aimed to test the feasibility of study methodology prior to commencing a large-scale study and investigate the effects of AKI on chronic kidney disease (CKD) progression and proteinuria. METHODS: Pilot study testing novel methodology for remote patient recruitment within a prospective case-control design. 300 cases (hospitalised patients with AKI) and controls (hospitalised patients without AKI) were matched 1:1 for age and baseline estimated glomerular filtration rate (eGFR). 70% of cases had AKI stage 1, 16% AKI stage 2 and 14% AKI stage 3. Renal function and proteinuria were measured 3 and 12 months after hospital admission. RESULTS: The study met pre-defined recruitment, withdrawal and matching criteria. Renal function was worse in ...
https://orda.derbyhospitals.nhs.uk/handle/123456789/341
The American Journal of Tropical Medicine and Hygiene | Intensive Care Unit Treatment of Acute Renal Failure Following Snake...The American Journal of Tropical Medicine and Hygiene | Intensive Care Unit Treatment of Acute Renal Failure Following Snake...
Abstract Twenty-nine patients with acute renal failure following bites by snakes of the genera Crotalus and Bothrops were treated in an Intensive Care Unit (ICU). Eight were given conservative treatment. Peritoneal dialysis was necessary in 21 patients, and hemodialysis in one of these. The main complications occurring while the patients were in the ICU were pulmonary edema (5 cases), respiratory failure (4), cardiac arrest (4), and hypovolemic shock (1 case). Three patients died with respiratory and hemodynamic disturbances while in the ICU, one of them during the polyuric phase. Twenty-four patients were discharged from the hospital with no clinical or laboratory evidence of renal failure. Two patients developed bilateral cortical necrosis of the kidney. One of them died in the general ward after interruption of dialysis and the other was discharged from the hospital with chronic renal failure. It was not possible to perform a kidney transplantation. The importance of the ICU in the recovery of such
http://www.ajtmh.org/content/journals/10.4269/ajtmh.1979.28.401
Acute Renal Failure (ARF) (Acute Kidney Injury)-Pipeline Insights, 2015 | Global Market Research ReportsAcute Renal Failure (ARF) (Acute Kidney Injury)-Pipeline Insights, 2015 | Global Market Research Reports
Acute Renal Failure (ARF) (Acute Kidney Injury)- Pipeline Insights, 2015, provides the in-depth analysis of the pipeline assets across the Acute Renal Failure (ARF) (Acute Kidney Injury). The main objective of this report to track competitor pipeline molecules, related research activities, technology, collaborations, in-licensing and out-licensing deals.
http://www.gosreports.com/acute-renal-failure-arf-acute-kidney-injury-pipeline-insights-2015/
Urinary Angiotensinogen and Risk of Severe AKI | American Society of NephrologyUrinary Angiotensinogen and Risk of Severe AKI | American Society of Nephrology
We identified candidate biomarkers for the prediction of the development of severe AKI, and the prognostic potential of the most promising candidate, angiotensinogen, was verified in a larger set of patients who developed AKI after cardiac surgery. We found that uAnCR was elevated in patients who developed more severe AKI after sample collection. Elevated uAnCR was associated with worsening of AKI, independent of changes in SCr and Cleveland Clinic score, and it was also associated with several secondary outcomes. The prognostic predictive power of uAnCR was improved when only patients who were classified as AKIN stage 1 at the time of sample collection were used in the analysis, indicating that angiotensinogen could be used to predict adverse outcomes among patients who have not yet developed severe AKI as measured by serum creatinine.. Our data suggest that angiotensinogen could be used at the time of diagnosis with AKI to assess the risk of adverse outcomes. This risk assessment could lead to ...
https://cjasn.asnjournals.org/content/8/2/184?ijkey=6e973e81774a8d4cd3229143341f8d1f0d2bb520&keytype2=tf_ipsecsha
Diagnosis of cardiac surgery-associated acute kidney injury from functional to damage biomarkersDiagnosis of cardiac surgery-associated acute kidney injury from functional to damage biomarkers
article{8506963, abstract = {Purpose of review : Acute kidney injury (AKI) occurs in up to 30\% after cardiac surgery and is associated with adverse outcome. Currently, cardiac surgery-associated acute kidney injury (CSA-AKI) is diagnosed by Kidney Disease: Improving Global Outcomes criteria based on creatinine and urine output. To detect and treat AKI earlier, various biomarkers have been evaluated. This review addresses the current position of the two damage biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and [TIMP-2] [IGFBP7] in clinical practice. Recent findings : We present an updated review on the use of blood and urinary NGAL in CSA-AKI. NGAL is a good predictor, and performs better in children than adults. There is a large variation in predictive ability, possibly caused by diversity of AKI definitions used, different time of measurement of NGAL, and lack of specificity of NGAL assays. Similarly, there are conflicting data on the predictive ability of urinary [TIMP-2] ...
https://biblio.ugent.be/publication/8506963
Acute kidney injury: how can we facilitate recovery?<...Acute kidney injury: how can we facilitate recovery?<...
TY - JOUR. T1 - Acute kidney injury: how can we facilitate recovery?. AU - Glassford, Neil John. AU - Bellomo, Rinaldo. N1 - 1531-7072 Glassford, Neil J Bellomo, Rinaldo Journal Article Review United States Curr Opin Crit Care. 2011 Dec;17(6):562-8. doi: 10.1097/MCC.0b013e32834cd334.. PY - 2011. Y1 - 2011. N2 - PURPOSE OF REVIEW: Successful renal recovery is a key goal of patient management during acute kidney injury in critically ill patients. However, limited information exists to guide clinicians as to what interventions might either decrease or increase the likelihood of renal recovery and especially renal recovery to dialysis independence. The purpose of this review is to analyse recent data and help clinicians with relevant therapeutic choices. RECENT FINDINGS: Two large trials, the Acute Renal Failure Trial Network (ATN) and Randomized Evaluation of Normal versus Augmented Level Renal Replacement Therapy (RENAL), provide important evidence on the possible impact of choice of renal ...
https://research.monash.edu/en/publications/acute-kidney-injury-how-can-we-facilitate-recovery
Knockout of interleukin-17A protects against sepsis-associated acute kidney injury | Annals of Intensive Care | Full TextKnockout of interleukin-17A protects against sepsis-associated acute kidney injury | Annals of Intensive Care | Full Text
Sepsis-associated acute kidney injury (SA-AKI) is an independent risk factor for death in patients with sepsis, but treatment for it is limited. To improve the diagnosis and treatment of SA-AKI, we must first understand its pathogenesis. Recently, interleukin (IL)-17A has been shown to be associated with the pathogenesis of acute kidney injury and sepsis, but its role in SA-AKI remains unclear. SA-AKI was induced in male C57BL/6 and IL-17A−/− mice using cecal ligation and puncture (CLP) operations for 24 h. At 7 days, only seven mice survived in the wild-type septic group, but nine survived in the IL-17A−/− septic group, corresponding to survival rates of 25 % and 45 %, respectively. At 24 h after CLP operations, both wild-type and IL-17A−/− septic mice developed kidney injury. The IL-17A−/− septic mice exhibited decreased serum creatinine and blood urea nitrogen levels and an improved acute tubular necrosis score. The IL-17A−/− septic mice exhibited decreased IL-6, interferon-γ,
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-016-0157-1
RNA silencingRNA silencing
Kidney disorders. QPI-1002/I5NP. Graft dysfunction kidney transplant. p53 Kidney disorders. QPI-1002/I5NP. Kidney injury acute ... Kidney disorders. QPI-1002/I5NP. Acute kidney injury. p53 ... kidney disorders, LDL lowering, and antiviral.[51] The ...
https://en.wikipedia.org/wiki/RNA_silencing
BUN-to-creatinine ratioBUN-to-creatinine ratio
Acute kidney injury (previously termed acute renal failure)[edit]. The ratio is predictive of prerenal injury when BUN:Cr ... The ratio may be used to determine the cause of acute kidney injury or dehydration. ... "Acute renal failure: urea:creatinine ratio was not very helpful in diagnosing prerenal failure". Evidence-Based On-Call ... This may be indicative of hypoperfusion of the kidneys due to heart failure or dehydration.[3] Gastrointestinal bleeding or ...
https://en.wikipedia.org/wiki/BUN-to-creatinine_ratio
AcetylcysteineAcetylcysteine
"Contrast medium induced acute kidney injury: a narrative review". Journal of Nephrology. 31 (6): 797-812. doi:10.1007/s40620- ... Kidney and bladder[edit]. Evidence for the benefit of acetylcysteine to prevent radiocontrast induced kidney disease is mixed.[ ... Wang AL, Wang JP, Wang H, Chen YH, Zhao L, Wang LS, Wei W, Xu DX (March 2006). "A dual effect of N-acetylcysteine on acute ... It is most effective in preventing or lessening hepatic injury when administered within 8-10 hours after overdose.[14] Research ...
https://en.wikipedia.org/wiki/N-Acetylcysteine
IschemiaIschemia
Zuk, Anna; Bonventre, Joseph V. (2016-01-14). "Acute Kidney Injury". Annual Review of Medicine. 67 (1): 293-307. doi:10.1146/ ... Sharfuddin, Asif A.; Molitoris, Bruce A. (April 2011). "Pathophysiology of ischemic acute kidney injury". Nature Reviews ... Munshi, Raj; Hsu, Christine; Himmelfarb, Jonathan (2011-02-02). "Advances in understanding ischemic acute kidney injury". BMC ... Several physical symptoms include shrinkage of one or both kidneys, renovascular hypertension, acute renal failure, progressive ...
https://en.wikipedia.org/wiki/Ischemia
Nephrogenic systemic fibrosisNephrogenic systemic fibrosis
... recovery from acute kidney injury (AKI), or performing a kidney transplant can slow or hold the progression of NSF. A few cases ... and those with acute kidney injury, even if kidney function subsequently returned to normal following GBCA administration.[13][ ... Bhaskaran A, Kashyap P, Kelly B, Ghera P (January 2010). "Nephrogenic systemic fibrosis following acute kidney injury and ... "Gadolinium-induced nephrogenic systemic fibrosis in a patient with an acute and transient kidney injury". The British Journal ...
https://en.wikipedia.org/wiki/Nephrogenic_systemic_fibrosis
PheochromocytomaPheochromocytoma
... leading to acute kidney injury and the need for transient dialysis in the undiagnosed pheochromocytoma patient as their primary ... "Contrast-Induced Acute Kidney Injury". Journal of the American College of Cardiology. 68 (13): 1465-1473. doi:10.1016/j.jacc. ... Kidney failure is brought about by catecholamine-induced muscle injury. Norepinephrine causes vessels to narrow, thereby ... Furthermore, if an acute adrenal hemorrhage is suspected in a pheochromocytoma patient, ultrasound is a quick, painless, ...
https://en.wikipedia.org/wiki/Pheochromocytoma
Blunt traumaBlunt trauma
Bosch X, Poch E, Grau JM (July 2009). "Rhabdomyolysis and acute kidney injury". The New England Journal of Medicine. 361 (1): ... The priority in assessing blunt trauma in sports injuries is separating contusions and musculo-tendinous injuries from injuries ... "Kidney injuries in professional American football: implications for management of an athlete with 1 functioning kidney". The ... Blunt injuries to the kidney from helmets, shoulder pads, and knees are described in American football, association football, ...
https://en.wikipedia.org/wiki/Blunt_trauma
RhabdomyolysisRhabdomyolysis
... in the absence of acute kidney injury, and 59% if kidney impairment occurs. Most people who have sustained kidney impairment ... Rhabdomyolysis accounts for 7-10% of all cases of acute kidney injury in the U.S. Crush injuries are common in major disasters ... Rhabdomyolysis complicated by acute kidney impairment in patients with traumatic injury may have a mortality rate of 20%. ... Of those with rhabdomyolysis, 10-50% develop acute kidney injury. The risk is higher in people with a history of illicit drug ...
https://en.wikipedia.org/wiki/Rhabdomyolysis
Guillain-Barré syndromeGuillain-Barré syndrome
... in-depth review of excipients and acute kidney injury risk". American Journal of Nephrology. 38 (4): 275-84. doi:10.1159/ ... Whether isolated acute sensory loss can be regarded as a form of Guillain-Barré syndrome is a matter of dispute; this is a rare ... Acute motor and sensory axonal neuropathy (AMSAN) Severe muscle weakness similar to AMAN but with sensory loss - Axonal ... Acute motor axonal neuropathy (AMAN) Isolated muscle weakness without sensory symptoms in less than 10%; cranial nerve ...
https://en.wikipedia.org/wiki/Guillain-Barre
Outcomes Research ConsortiumOutcomes Research Consortium
And neither prevents acute kidney injury. How to prevent perioperative myocardial injury remains under active investigation, ... "Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial". JAMA. 312 (21): 2254-64. doi ... What causes acute surgical pain to become persistent remains unclear. However, it seems likely to result from some combination ... Wang L, Bauer M, Curry R, Larsson A, Sessler DI, Eisenach JC (October 2014). "Intrathecal ketorolac does not improve acute or ...
https://en.wikipedia.org/wiki/Outcomes_Research_Consortium
CirrhosisCirrhosis
Acute kidney injury (particularly hepatorenal syndrome). Cachexia associated with muscle wasting and weakness. Cirrhosis has ... This injury happens through the formation of acetaldehyde from alcohol which itself is reactive, but which also leads to the ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 2009-11-11. Retrieved ... Chronic hepatitis B. The hepatitis B virus causes liver inflammation and injury that over several decades can lead to cirrhosis ...
https://en.wikipedia.org/wiki/Cirrhosis
FibrateFibrate
Drug toxicity includes acute kidney injury. Although used clinically since the 1930s,[failed verification] if not earlier, the ... April 2012). "New fibrate use and acute renal outcomes in elderly adults: a population-based study". Annals of Internal ... leading to kidney failure. The less lipophilic statins are less prone to cause this reaction, and are probably safer when ...
https://en.wikipedia.org/wiki/Fibrate
NephrocalcinosisNephrocalcinosis
It may cause acute kidney injury. It is now more commonly used to describe diffuse, fine, renal parenchymal calcification in ... There are several causes of nephrocalcinosis that are typically acute and present only with kidney failure. These include tumor ... However, it may be severe enough to cause (as well as be caused by) renal tubular acidosis or even end stage kidney disease, ... Medullary sponge kidney Distal renal tubular acidosis Hyperoxaluria Renal papillary necrosis And other causes of hypercalcemia ...
https://en.wikipedia.org/wiki/Nephrocalcinosis
RNA interferenceRNA interference
Kidney injury, acute renal failure I Completed Quark Pharmaceuticals NCT00554359 Delayed graft function, complications of ... siRNA is controlled by the innate immune system, which can be divided into the acute inflammatory responses and antiviral ... RNAi uptake and regulation is monitored by the kidneys.[166] ... kidney transplant I, II Recruiting Quark Pharmaceuticals ...
https://en.m.wikipedia.org/wiki/RNA_interference
Contrast-induced nephropathyContrast-induced nephropathy
... to prevent contrast-induced acute kidney injury and to slow progression of chronic kidney disease. Dosing trials began in June ... Sadat U, Usman A, Gillard JH, Boyle JR (2013). "Does ascorbic acid protect against contrast-induced acute kidney injury in ... Given the increasing doubts about the contribution of radiocontrast to acute kidney injury, the American College of Radiology ... "Acute Kidney Injury After Computed Tomography: A Meta-analysis". Annals of Emergency Medicine. 71 (1): 44-53.e4. doi:10.1016/j. ...
https://en.wikipedia.org/wiki/Contrast-induced_nephropathy
Synthetic cannabinoidsSynthetic cannabinoids
On the other hand, some adverse effects are not usually seen in marijuana at any dose, such as acute kidney injury, cardiac ... August 2014). "Acute kidney injury associated with smoking synthetic cannabinoid". Clinical Toxicology. 52 (7): 664-73. doi: ... reported acute kidney injury. Four postmortem cases linked to the synthetic cannabinoids 5F-PB-22 have been reviewed. The ... Abouchedid R, Ho JH, Hudson S, Dines A, Archer JR, Wood DM, Dargan PI (December 2016). "Acute Toxicity Associated with Use of ...
https://en.wikipedia.org/wiki/Synthetic_cannabinoids
IbuprofenIbuprofen
Fanos V, Antonucci R, Zaffanello M (2010). "Ibuprofen and acute kidney injury in the newborn". The Turkish Journal of ... acute kidney failure, cyanosis, respiratory depression, and cardiac arrest have been reported. The severity of symptoms varies ... It increases the risk of heart failure, kidney failure, and liver failure. At low doses, it does not appear to increase the ... "NSAIDs may cause rare kidney problems in unborn babies". U.S. Food and Drug Administration. 21 July 2017. Retrieved 15 October ...
https://en.wikipedia.org/wiki/Ibuprofen
GlomerulonephrosisGlomerulonephrosis
"Causal relationship between hypoalbuminemia and acute kidney injury". World Journal of Nephrology. 6 (4): 176-187. doi:10.5527/ ... "Lupus and Kidney Disease (Lupus Nephritis) , NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. ... In severe cases where the condition has progressed to chronic kidney disease, kidney transplantation will be ultimately be ... the progression to kidney disease is very common and individuals will inevitably require kidney transplant. If left untreated ...
https://en.wikipedia.org/wiki/Glomerulonephrosis
Fluid replacementFluid replacement
"Fluid Management and Use of Diuretics in Acute Kidney Injury". Advances in Chronic Kidney Disease. 20 (1): 45-55. doi:10.1053/j ... However, fluid overload can exacerbates acute kidney injury. The use of diuretics does not prevent or treat AKI even with the ... Sepsis accounts for 50% of acute kidney injury patients in (intensive care unit) (ICU). Intravenous crystalloid is recommended ... W Schrier, Robert (2010). "Fluid Administration in Critically Ill Patients with Acute Kidney Injury". Clinical Journal of the ...
https://en.wikipedia.org/wiki/Fluid_replacement
Weekend effectWeekend effect
... acute kidney injury, and mortality". J Am Soc Nephrol. 21 (5): 845-51. doi:10.1681/ASN.2009070682. PMC 2865737. PMID 20395373. ... Bell et al., in 2013, surveyed 91 acute hospital sites in England to evaluate systems of consultant cover for acute medical ... Injury. 47 (6): 1236-41. doi:10.1016/j.injury.2016.02.021. PMID 27084114.CS1 maint: multiple names: authors list (link) Worni M ... "The weekend effect alters the procurement and discard rates of deceased donor kidneys in the United States". Kidney Int. 90 (1 ...
https://en.wikipedia.org/wiki/Weekend_effect
Pulmonary artery catheterPulmonary artery catheter
Acute renal failure aka Acute Kidney Injury. *Burns. *Management of postoperative open heart surgical patients ...
https://en.m.wikipedia.org/wiki/Pulmonary_artery_catheter
AcetylcysteineAcetylcysteine
"Contrast medium induced acute kidney injury: a narrative review". Journal of Nephrology. 31 (6): 797-812. doi:10.1007/s40620- ... Wang AL, Wang JP, Wang H, Chen YH, Zhao L, Wang LS, Wei W, Xu DX (March 2006). "A dual effect of N-acetylcysteine on acute ... This may lead to severe liver damage and even death by acute liver failure. In the treatment of acetaminophen overdose, ... It is most effective in preventing or lessening hepatic injury when administered within 8-10 hours after overdose. Research ...
https://en.wikipedia.org/wiki/Acetylcysteine
Renal stem cellRenal stem cell
Humphreys, BD; Duffield, JS; Bonventre, JV (2006). "Renal stem cells in recovery from acute kidney injury". Minerva Urologica e ... It is involved in the homeostasis and repair of the kidney, and holds therapeutic potential for treatment of kidney failure. ... "Intrinsic Epithelial Cells Repair the Kidney after Injury". Cell Stem Cell. 2 (3): 284-91. doi:10.1016/j.stem.2008.01.014. PMID ... "Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury". Stem Cells. 28 (3): ...
https://en.wikipedia.org/wiki/Renal_stem_cell
GyromitrinGyromitrin
Of those 27 analyzed cases, nine developed liver injury; there were also three instances of acute kidney injury. As gyromitrin ... Dialysis can be used if kidney function is impaired or the kidneys are failing. Hemolysis may require a blood transfusion to ... which can lead to kidney toxicity or kidney failure. Methemoglobinemia may also occur in some cases. This is where higher than ... Braun R, Greeff U, Netter KJ (1979). "Liver injury by the false morel poison gyromitrin". Toxicology. 12 (2): 155-63. doi: ...
https://en.wikipedia.org/wiki/Gyromitrin
Exertional rhabdomyolysisExertional rhabdomyolysis
"Risk Factors for Acute Kidney Injury in Severe Rhabdomyolsis." PLOSONE 10.1371 (2013). Web. 25 Jan 2014. Poortsmans, JR. ... In some cases ER can lead to acute kidney failure and bring medical costs up due to the need for hemodialysis for recovery/ ... Acute Exertional Rhabdomyolysis. Aug. 1995 Retrieved 22 Jan. 2014 Demos, M. A., E. L. Gitin, and L. J. Kagen. "Exercise ... Vanderstraten, J. "Kidney function during exercise in healthy and diseased human. An Update." Sports Medicine 18.6 (1994): 419- ...
https://en.wikipedia.org/wiki/Exertional_rhabdomyolysis
Ronyó - Viquipèdia, lenciclopèdia lliureRonyó - Viquipèdia, l'enciclopèdia lliure
Naqvi, R; Akhtar, F; Farooq, U; Ashraf, S; Hasan Rizvi, SAH «From diamonds to black stone; myth to reality: Acute kidney injury ... Understanding the kidney one cell at a time (en anglès). Kidney Int, 2019 Oct; 96 (4), pp: 862-870. PMID: 31492507. DOI 10.1016 ... Tanaka, Shinji; Okusa, Mark D. Crosstalk between the nervous system and the kidney (en anglès). Kidney Int, 2020 Mar; 97 (3) , ... Rayner, Hugh C.; Thomas, Mark A.B.; Milford, David V. Kidney Anatomy and Physiology (en anglès). A: Understanding Kidney ...
https://ca.wikipedia.org/wiki/Ronyó
Loop diureticLoop diuretic
"Fluid Management and Use of Diuretics in Acute Kidney Injury". Advances in Chronic Kidney Disease. 20 (1): 45-55. doi:10.1053/j ... Diuretics has not shown any benefits of preventing or treating acute kidney injury. They are also sometimes used in the ... guidelines stated that diuretics should not be used to treat acute kidney injury, except for the management of volume overload ... Loop diuretics are diuretics that act at the ascending limb of the loop of Henle in the kidney. They are primarily used in ...
https://en.wikipedia.org/wiki/Loop_diuretic
DoxylamineDoxylamine
Rarely, an overdose results in rhabdomyolysis and acute kidney injury. Studies of doxylamine's carcinogenicity in mice and rats ...
https://en.wikipedia.org/wiki/Doxylamine
ClarithromycinClarithromycin
"Calcium-channel blocker-clarithromycin drug interactions and acute kidney injury". JAMA. 310 (23): 2544-53. doi:10.1001/jama. ... It should not be used with colchicine in people with kidney or liver impairment. Concomitant use with cholesterol medications ...
https://en.wikipedia.org/wiki/Clarithromycin
SitagliptinSitagliptin
... including acute kidney injury (sometimes requiring dialysis); severe and disabling arthralgia; constipation; vomiting; headache ... The existence of rare case reports of kidney failure and hypersensitivity reactions is noted in the United States prescribing ... Serious side effects may include angioedema, low blood sugar, kidney problems, pancreatitis, and joint pain. Whether use in ... "www.merck.com" (PDF). Olansky L (2010). "Do incretin-based therapies cause acute pancreatitis?". Journal of Diabetes Science ...
https://en.wikipedia.org/wiki/Sitagliptin
T细胞 - 维基百科，自由的百科全书T细胞 - 维基百科，自由的百科全书
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nature Immunology ... Alpha-lactose reverses liver injury via blockade of Tim-3-mediated CD8 apoptosis in sepsis. Clinical Immunology. July 2018, 192 ... Disappearance of T Cell-Mediated Rejection Despite Continued Antibody-Mediated Rejection in Late Kidney Transplant Recipients. ... Hepatitis B Virus-Specific CD8+ T Cells Maintain Functional Exhaustion after Antigen Reexposure in an Acute Activation Immune ...
https://zh.m.wikipedia.org/wiki/T细胞
Type 2 diabetesType 2 diabetes
"National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 6 March 2016. ... GBD 2015 Disease and Injury Incidence and Prevalence Collaborators) (October 2016). "Global, regional, and national incidence, ... "National Institute of Diabetes and Digestive and Kidney Diseases. June 2014. Archived from the original on 2 February 2016. ... National Institute of Diabetes and Digestive and Kidney Diseases, NIH. March 2007. Archived from the original on 2008-07-04. ...
https://en.wikipedia.org/wiki/Type_2_diabetes_mellitus
EbolaEbola
Non-infectious diseases that may result in symptoms similar to those of EVD include acute promyelocytic leukaemia, haemolytic ... along with decreased function of the liver and kidneys.[1] At this time, some people begin to bleed both internally and ... The breakdown of endothelial cells leading to blood vessel injury can be attributed to EBOV glycoproteins. This damage occurs ... Dialysis may be needed for kidney failure, and extracorporeal membrane oxygenation may be used for lung dysfunction.[33] ...
https://en.m.wikipedia.org/wiki/Ebola_virus_disease
Hematopoietic stem cell transplantationHematopoietic stem cell transplantation
Acute graft-versus-host disease typically occurs in the first 3 months after transplantation and may involve the skin, ... Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of bilirubin, hepatomegaly and fluid ... The injury of the mucosal lining of the mouth and throat is a common regimen-related toxicity following ablative HSCT regimens ... However, it is less effective in rapidly growing acute leukemias.[38] If cancer relapses after HSCT, another transplant can be ...
https://en.wikipedia.org/wiki/Bone_Marrow_Transplant
MedicineMedicine
Physical medicine and rehabilitation (or physiatry) is concerned with functional improvement after injury, illness, or ... These include treatment of acute and chronic illnesses, preventive care and health education for all ages and both sexes. ... For example, gastroenterologists and nephrologists specialize respectively in diseases of the gut and the kidneys.[23] ... Sports medicine deals with the treatment and prevention and rehabilitation of sports/exercise injuries such as muscle spasms, ...
https://en.wikipedia.org/wiki/Medical
Brain tumorBrain tumor
GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... brain tumors are second only to acute lymphoblastic leukemia as the most common form of cancer.[8] In Australia, the average ... kidney cancer, and colon cancer (in decreasing order of frequency). ... in part by shuttling different compounds around in response to injury or other stimulus. ...
https://en.m.wikipedia.org/wiki/Brain_tumors
Hypervitaminosis AHypervitaminosis A
Acute toxicity occurs over a period of hours or a few days, and is less of a problem than chronic toxicity. ... while the lung and kidneys may also be capable of storage.[20] ... on ethanol-induced mitochondrial injury in rats". Biochemical ... "The acute and chronic toxic effects of vitamin A". The American Journal of Clinical Nutrition. 83 (2): 191-201. PMID 16469975 ...
https://en.m.wikipedia.org/wiki/Hypervitaminosis_A
Joint dislocationJoint dislocation
Many different knee injuries can happen. Three percent of knee injuries are acute traumatic patellar dislocations.[25] Because ... "Injury. 41 (4): 329-334. doi:10.1016/j.injury.2009.08.007.. *^ Ringleb, Stacie I.; Dhakal, Ajaya; Anderson, Claude D.; Bawab, ... Blunt kidney trauma. *Ruptured spleen. *Neuro *Penetrating head injury. *Traumatic brain injury ... as injury to these structures may occur during the injury or during the reduction process.[3] Subsequent imaging studies are ...
https://en.wikipedia.org/wiki/Joint_dislocation
肥胖症 - 维基百科，自由的百科全书肥胖症 - 维基百科，自由的百科全书
Diet Drug Orlistat Linked to Kidney, Pancreas Injuries. Medscape. Medscape News. [2011-04-26]. （原始内容存档于2012-05-10）.. ... The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk stratification of ...
https://zh.wikipedia.org/wiki/肥胖
Lactose intoleranceLactose intolerance
Secondary lactose intolerance is due to injury to the small intestine. Such injury could be the result of infection, celiac ... "National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. Archived from the original on ... It may be caused by acute gastroenteritis, coeliac disease, Crohn's disease, ulcerative colitis,[30] chemotherapy, intestinal ... Decreased ability to digest lactose (genetic, small intestine injury)[1]. Diagnostic method. Symptoms resolve following ...
https://en.wikipedia.org/wiki/Lactose_intolerance
InjuryInjury
Acute kidney injury. *Knee injury *Anterior cruciate ligament injury. *Medial knee injuries ... Injury from internal causes such as reperfusion injury. By locationEdit. *Wound, an injury in which skin is torn, cut or ... Illness and injuries during spaceflight. Injury severity scoreEdit. The injury severity score (ISS) is a medical score to ... Repetitive strain injury or other strain injury. *Other injuries from external physical causes, such as radiation poisoning, ...
https://en.m.wikipedia.org/wiki/Injury
Brain-derived neurotrophic factorBrain-derived neurotrophic factor
... kidneys, prostate, motor neurons and skeletal muscle and it is also found in saliva.[13][14] ... "Organ-specific physiological responses to acute physical exercise and long-term training in humans". Physiology. 29 (6): 421-36 ... a widely expressed activity-dependent neurotic factor that regulates plasticity and is unregulated following hypoxic injury. ...
https://en.wikipedia.org/wiki/BDNF
Urinary tract infectionUrinary tract infection
However recurrent UTIs are a rare cause of further kidney problems if there are no underlying abnormalities of the kidneys, ... Persons with spinal cord injury are at increased risk for urinary tract infection in part because of chronic use of catheter, ... Colgan, R; Williams, M (1 October 2011). "Diagnosis and treatment of acute uncomplicated cystitis". American Family Physician. ... Cephalexin or nitrofurantoin are typically used because they are generally considered safe in pregnancy.[76] A kidney infection ...
https://en.wikipedia.org/wiki/Urinary_Tract_Infections
Mold health issuesMold health issues
August 1998). "Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi". Arch ... in a toxic mold-related personal injury lawsuit against the owners and managers of their apartment in Sacramento, California.[ ... kidney failure, and liver failure.[13] ... of effects from reduced appetite and general malaise to acute ...
https://en.m.wikipedia.org/wiki/Toxic_mold
GallstoneGallstone
... and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic ... "National Institute of Diabetes and Digestive and Kidney Diseases. November 2017.. *^ editors, Ronnie A. Rosenthal, Michael E. ... National Institute of Diabetes and Digestive and Kidney Diseases (2007). "Gallstones" (PDF). Bethesda, Maryland: National ... and acute pancreatitis as blockage of the bile ducts can prevent active enzymes being secreted into the bowel, instead damaging ...
https://en.m.wikipedia.org/wiki/Gallstones
Vitamin CVitamin C
There is a longstanding belief among the mainstream medical community that vitamin C increases risk of kidney stones.[54] " ... so it exhibits remarkably low acute toxicity.[4] More than two to three grams may cause indigestion, particularly when taken on ... Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury". Nutrition and Metabolic ... Reptiles and older orders of birds make ascorbic acid in their kidneys. Recent orders of birds and most mammals make ascorbic ...
https://en.wikipedia.org/wiki/L-ascorbic_acid
University of Texas Health Science Center at San AntonioUniversity of Texas Health Science Center at San Antonio
University Hospital ranked among top 50 hospitals in the U.S. in three specialties: Respiratory Disorders, Kidney Disease and ... School of Nursing: Acute Nursing Care, Chronic Nursing Care, Family Nursing Care. ... Injury Prevention and Research Center. *Institute of Biotechnology. *Institutional Flow Cytometry Core Facility ...
https://en.wikipedia.org/wiki/GSBS
Common ostrichCommon ostrich
Kidney function. Common ostrich kidneys are fairly large, and so are able to hold significant amounts of solutes. Hence, common ... With their acute eyesight and hearing, common ostriches can sense predators such as lions from far away. When being pursued by ... When threatened, common ostriches run away, but they can cause serious injury and death with kicks from their powerful legs.[33 ... A number of avian species use nasal salt glands, alongside their kidneys, to control hypertonicity in their blood plasma.[79] ...
https://en.m.wikipedia.org/wiki/Common_ostrich
Brain-derived neurotrophic factorBrain-derived neurotrophic factor
"Organ-specific physiological responses to acute physical exercise and long-term training in humans". Physiology. 29 (6): 421-36 ... a widely expressed activity-dependent neurotic factor that regulates plasticity and is unregulated following hypoxic injury. ... the kidneys, saliva, and the prostate.[11] ...
https://en.wikipedia.org/wiki/Brain_derived_neurotrophic_factor
Kidney diseaseKidney disease
Acute kidney disease is now termed acute kidney injury and is marked by the sudden reduction in kidney function over seven days ... The most common form of kidney disease in cancer patients is Acute Kidney Injury (AKI) which can usually be due to volume ... Several chemotherapeutic agents, for example Cisplatin, are associated with acute and chronic kidney injuries.[20] Newer agents ... the complete loss of kidney function. Kidney failure is known as the end-stage of kidney disease, where dialysis or a kidney ...
https://en.m.wikipedia.org/wiki/Nephropathy
Debelost - Wikipedija, prosta enciklopedijaDebelost - Wikipedija, prosta enciklopedija
"Diet Drug Orlistat Linked to Kidney, Pancreas Injuries". Medscape. Medscape News. Pridobljeno dne 26 April 2011.. ... julij 2006). "The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk ...
https://sl.m.wikipedia.org/wiki/Debelost
Frailty syndromeFrailty syndrome
... chronic kidney disease, depression, and cognitive impairment;[2] (b) physiologic impairments, such as activation of ... injury, or even changes in medication) that characterizes many older adults.[1] ... "Developing and validating a risk prediction model for acute care based on frailty syndromes". BMJ Open. 5 (10): e008457. doi ...
https://en.wikipedia.org/wiki/Frailty_syndrome
Posttraumatic stress disorderPosttraumatic stress disorder
Blunt kidney trauma. *Ruptured spleen. *Neuro *Penetrating head injury. *Traumatic brain injury ... VA/DOD Clinical Practice Guideline for the Management of Posttraumatic Stress Disorder and Acute Stress Disorder (PDF). United ... doi:10.1016/j.injury.2012.02.015. PMID 22409991.. *^ Kassam-Adams N, Marsac ML, Hildenbrand A, Winston F (December 2013). " ... "The Operational Stress Injury Social Support (OSISS) Program for Canadian Veterans". Archived from the original on 6 July 2011. ...
https://en.wikipedia.org/wiki/Posttraumatic_stress_disorder
KetorolacKetorolac
"NSAIDs may cause rare kidney problems in unborn babies". U.S. Food and Drug Administration. 21 July 2017. Retrieved 15 October ... Competitive sports athletes, particularly in contact sports, are often required to play through injuries.[32] In the late 1990s ... "Non-Steroidal Anti-Inflammatory Drugs and Aspirin Therapy for the Treatment of Acute and Recurrent Idiopathic Pericarditis" ... The risk of toxicity to the kidneys increases when ketorolac is taken with cyclosporine.[8][9] ...
https://en.wikipedia.org/wiki/Ketorolac
QuinineQuinine
... acute kidney injury, liver toxicity, and blindness.[27] In people with atrial fibrillation, conduction defects, or heart block ... Some people who have developed TTP due to quinine have gone on to develop kidney failure.[28] It can also cause serious ...
https://en.wikipedia.org/wiki/Quinine
National Institutes of HealthNational Institutes of Health
General/Acute/Emergency. *Adventist HealthCare - Fort Washington. *Adventist HealthCare - Shady Grove. *Adventist HealthCare - ... National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD). *National Institute on Drug Abuse (NIDA) ... National Center for Injury Prevention and Control. *Food and Drug Administration. *Health Resources and Services Administration ...
https://en.wikipedia.org/wiki/National_Institute_of_Health
Hypertensive emergencyHypertensive emergency
The kidneys will be affected, resulting in blood and/or protein in the urine, and acute kidney failure. ... Endothelial injury and dysfunction. *Fibrinoid necrosis of the arterioles. *Deposition of platelets and fibrin ... acute pulmonary edema, and aortic dissection. Other end-organ damage can include acute kidney failure or insufficiency, ... In the kidneys, chronic hypertension has a great impact on the renal vasculature, leading to pathologic changes in the small ...
https://en.wikipedia.org/wiki/Hypertensive_emergency
Retrograde urethrogramRetrograde urethrogram
Retrograde ureteral, an intervention used to remove kidney stones. References[edit]. *^ El-Ghar MA, Osman Y, Elbaz E, Refiae H ... If a urethral injury is suspected, a retrograde urethrogram should be performed before attempting to place a Foley catheter ... Hence a retrograde urethrogram is essential for diagnosis of urethral injury, or urethral stricture.[1] ... leakage of the contrast suggests urethral injury (usually secondary to pelvic trauma) and is an indication for surgical ...
https://en.wikipedia.org/wiki/Retrograde_urethrogram
Stress ulcerStress ulcer
It is believed that shunting of blood away from the mucosa makes the mucous membrane ischaemic and more susceptible to injury. ... Occasionally, there may be a large acute ulcer in the duodenum (Curling's ulcer). Generally, there are multiple lesions located ... kidney failure, stroke, hypertension, previous gastrointestinal disease and treatment with corticosteroids, NSAIDS, heparin, or ...
https://en.wikipedia.org/wiki/Stress_ulcer
BaclofenBaclofen
Acute withdrawal symptoms can be stopped by recommencing baclofen.[8]. Withdrawal symptoms may include auditory hallucinations ... Biotransformation is low: the drug is predominantly excreted unchanged by the kidneys.[20] The half-life of baclofen is roughly ... Baclofen is primarily used for the treatment of spastic movement disorders, especially in instances of spinal cord injury, ... is a medication used to treat muscle spasticity such as from a spinal cord injury or multiple sclerosis.[1][2] It may also be ...
https://en.m.wikipedia.org/wiki/Baclofen
Update on Perioperative Acute Kidney InjuryUpdate on Perioperative Acute Kidney Injury
This review discusses the epidemiology and pathophysiology of surgery-associated acute kidney injury, highlighting the ... acute kidney injury; FDA, Food and Drug Administration; IGFBP7, insulin-like growth factor-binding protein 7; KDIGO, Kidney ... Update on Perioperative Acute Kidney Injury. Alexander Zarbock, MD; Jay L. Koyner, MD; Eric A. J. Hoste, MD; John A. Kellum, MD ... Abbreviations: AKI, acute kidney injury; eGFR, estimated glomerular filtration rate; RRT, renal replacement therapy. ...
https://www.medscape.com/viewarticle/903779_6
Sepsis associated acute kidney injury | The BMJSepsis associated acute kidney injury | The BMJ
Sepsis associated acute kidney injury. BMJ 2019; 364 doi: https://doi.org/10.1136/bmj.k4891 (Published 09 January 2019) Cite ... Meta-analysis of frusemide to prevent or treat acute renal failure. Published: 21 July 2006; BMJ doi:10.1136/bmj.38902.605347. ... Meta-analysis of frusemide to prevent or treat acute renal failure. Published: 24 August 2006; BMJ 333 doi:10.1136/bmj. ...
https://www.bmj.com/content/364/bmj.k4891/related
Non-dialytic Management of Acute Kidney Injury | SpringerLinkNon-dialytic Management of Acute Kidney Injury | SpringerLink
The treatment of acute kidney injury (AKI) prior to institution of renal replacement therapy (RRT) has traditionally focused on ... Acute Kidney Injury Work Group: KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:1-138. ... Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31. ... Non-dialytic Management of Acute Kidney Injury. In: Waikar S., Murray P., Singh A. (eds) Core Concepts in Acute Kidney Injury. ...
https://link.springer.com/chapter/10.1007%2F978-1-4939-8628-6_19
Neonatal Acute Kidney Injury Workshop | NIDDKNeonatal Acute Kidney Injury Workshop | NIDDK
Reviewed state-of-the-art knowledge of acute kidney injury (AKI) in neonates and determined the feasibility of studying this ... The purpose of this conference is to: (1) review the state-of-the-art knowledge of acute kidney injury (AKI) in neonates; and ( ... What Do We Know About Long-term Kidney Outcomes in Neonatal Survivors? Cherry Mammen, M.D.. 9:30 a.m.. What Do We Know About ... The National Institute of Diabetes and Digestive and Kidney Diseases. Health Information Center ...
https://www.niddk.nih.gov/news/meetings-workshops/2013/neonatal-acute-kidney-injury-workshop
Neonatal Acute Kidney Injury. - PubMed - NCBINeonatal Acute Kidney Injury. - PubMed - NCBI
Neonatal Acute Kidney Injury.. Selewski DT1, Charlton JR2, Jetton JG3, Guillet R4, Mhanna MJ5, Askenazi DJ6, Kent AL7. ... In recent years, there have been significant advancements in our understanding of acute kidney injury (AKI) and its impact on ... In an effort to begin to address these needs, the Neonatal Kidney Collaborative was formed in 2014 with the goal of better ... We put forth and describe the neonatal modified Kidney Diseases: Improving Global Outcomes AKI criteria and provide the ...
https://www.ncbi.nlm.nih.gov/pubmed/26169430
Novel Developments in Acute Kidney InjuryNovel Developments in Acute Kidney Injury
... Guest Editors: Jeremiah R. Brown, Peter A. McCullough, and Michael E. Matheny *Novel ... Functional Magnetic Resonance Imaging in Acute Kidney Injury: Present Status, Hai Ying Zhou, Tian Wu Chen, and Xiao Ming Zhang ... Hospital Mortality in the United States following Acute Kidney Injury, Jeremiah R. Brown, Michael E. Rezaee, Emily J. Marshall ... Clinical Characteristics and 30-Day Outcomes of Intermittent Hemodialysis for Acute Kidney Injury in an African Intensive Care ...
https://www.hindawi.com/journals/bmri/si/561304/
Pediatric Acute Kidney InjuryPediatric Acute Kidney Injury
Learn more about how this affects kidney function. ... Pediatric acute kidney injury occurs when kidneys begin to fail ... Acute (sudden) kidney injury, formerly called acute renal failure, occurs when a kidney is damaged suddenly due to an illness ... Pediatric acute kidney injury refers to the sudden loss of kidney function due to an underlying illness. ... not because of a blow or injury to a kidney as the name might suggest. Its a sudden onset of kidney failure that can happen ...
https://www.childrens.com/specialties-services/specialty-centers-and-programs/nephrology/programs-and-services/end-stage-kidney-renal-disease/acute-kidney-injury
Pediatric Acute Kidney InjuryPediatric Acute Kidney Injury
Learn more about how this affects kidney function. ... Pediatric acute kidney injury occurs when kidneys begin to fail ... Pediatric Acute Kidney Injury. Pediatric acute kidney injury refers to the sudden loss of kidney function due to an underlying ... What is a Pediatric Acute Kidney Injury?. Acute (sudden) kidney injury, formerly called acute renal failure, occurs when a ... What are the causes of a Pediatric Acute Kidney Injury?. Causes of acute kidney injury include:. Slow blood flow caused by:. * ...
https://www.childrens.com/specialties-services/conditions/acute-kidney-injury
Acute kidney injury | Guidance and guidelines | NICEAcute kidney injury | Guidance and guidelines | NICE
... detection and management of non-traumatic acute kidney injury (AKI) ... Assessment for acute kidney injury. Clinical assessment for acute kidney injury involves doing a blood test to check serum ... no clear acute component and 1 or more indications or risk factors for acute kidney injury are assessed for acute kidney injury ... no clear acute component and 1 or more indications or risk factors for acute kidney injury are assessed for acute kidney injury ...
https://www.nice.org.uk/guidance/qs76/chapter/Quality-statement-2-Identifying-acute-kidney-injury-in-people-with-no-obvious-acute-illness
Mediators of Inflammation in Acute Kidney InjuryMediators of Inflammation in Acute Kidney Injury
... and lymphocytes infiltrate into the injured kidneys. The injury induces the generation of inflammatory mediators like cytokines ... Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity. Inflammation is now believed to ... and chemokines by tubular and endothelial cells which contribute to the recruiting of leukocytes into the kidneys. Thus, ... "Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy," Kidney International, vol ...
https://www.hindawi.com/journals/mi/2009/137072/
Overview | Acute kidney injury | Quality standards | NICEOverview | Acute kidney injury | Quality standards | NICE
... detection and management of non-traumatic acute kidney injury (AKI) ... detecting and managing acute kidney injury in adults, young people and children. Acute kidney injury is sudden damage to the ... It does not cover managing acute kidney injury in pregnant women or in people with a kidney transplant. ... Quality statement 2: Identifying acute kidney injury in people with no obvious acute illness ...
https://www.nice.org.uk/guidance/qs76
Acute Kidney Injury Associated with Synthetic Cannabinoid Use - Multiple States, 2012Acute Kidney Injury Associated with Synthetic Cannabinoid Use - Multiple States, 2012
Sixteen cases of acute kidney injury following exposure to SCs were identified in six states with illness onset during March 16 ... Acute Kidney Injury Associated with Synthetic Cannabinoid Use - Multiple States, 2012. In March 2012, the Wyoming Department of ... Results of toxicologic analysis of implicated products and/or clinical specimens from seven patients with acute kidney injury ... Chronic kidney disease after kidney injury: a systemic review and meta-analysis. Kid Int 2012;81:442-8. ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6206a1.htm
Follow-up care for acute kidney injury may be lacking - ReutersFollow-up care for acute kidney injury may be lacking - Reuters
Reuters Health) - Kidney specialists recommend follow-up care for most patients who have experienced acute kidney injury, but ... "Acute kidney injury refers to a sudden loss of kidney function that usually develops over the course of days in patients who ... "Kidney problems can resolve after an acute kidney injury; however, some - but not all - patients can develop long-term ... Reuters Health) - Kidney specialists recommend follow-up care for most patients who have experienced acute kidney injury, but ...
https://www.reuters.com/article/us-kidney-injury-followup/follow-up-care-for-acute-kidney-injury-may-be-lacking-idUSKBN1CP2EW
Acute Kidney InjuryAcute Kidney Injury
... which means your kidneys suddenly stop working normally. Includes prerenal acute kidney injury. Covers causes like kidney or ... which used to be called acute renal failure), ... What is acute kidney injury?. Acute kidney injury (which used ... What causes acute kidney injury?. Acute kidney injury has three main causes:. *A sudden, serious drop in blood flow to the ... Acute Kidney Injury Work Group (2012). KDIGO clinical practice guideline for acute kidney injury. Kidney International ...
https://www.rexhealth.com/app/healthwise/document.aspx?id=aa115361
Acute Kidney InjuryAcute Kidney Injury
... , Acute Renal Failure, Acute Renal Insufficiency, Renal Failure, Azotemia, Uremia, Acute Tubular Necrosis, ... Acute kidney injury, Acute Kidney Injury, Acute Renal Injuries, Renal Injury, Acute, Acute Kidney Injuries, Acute Renal Injury ... Acute Kidney Injury Acute Kidney Injury Causes Acute Kidney Injury Management Acute Kidney Injury Prognosis Acute Kidney Injury ... Acute Kidney Injury. Acute Kidney Injury Aka: Acute Kidney Injury, Acute Renal Failure, Acute Renal Insufficiency, Renal ...
http://www.fpnotebook.com/Renal/Failure/ActKdnyInjry.htm
Global epidemiology and outcomes of acute kidney injury. - PubMed - NCBIGlobal epidemiology and outcomes of acute kidney injury. - PubMed - NCBI
Global epidemiology and outcomes of acute kidney injury.. Hoste EAJ1, Kellum JA2, Selby NM3, Zarbock A4, Palevsky PM5, Bagshaw ... Acute kidney injury (AKI) is a commonly encountered syndrome associated with various aetiologies and pathophysiological ... Full recovery of kidney function is uncommon, which leaves these patients at risk of long-term morbidity and death. Estimates ... Centre for Kidney Research and Innovation, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, ...
https://www.ncbi.nlm.nih.gov/pubmed/30135570?dopt=Abstract
Vitamin B-3 may treat and prevent acute kidney injuryVitamin B-3 may treat and prevent acute kidney injury
... shows that raising vitamin B-3 levels may benefit patients who have undergone major surgery and are at risk of developing acute ... Low enzyme levels and acute kidney injury. Dr. Parikh and team studied the metabolism of mice with acute kidney injury. Urine ... Acute kidney injury occurs when waste products accumulate in the blood and the kidneys struggle to maintain a good balance of ... In acute kidney injury, the kidneys suddenly stop functioning - usually as a result of complications during hospitalization. ...
https://www.medicalnewstoday.com/articles/amp/322828
JCI - Cellular pathophysiology of ischemic acute kidney injuryJCI - Cellular pathophysiology of ischemic acute kidney injury
... leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury ... Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components ... and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize ... of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, ...
https://www.jci.org/articles/view/45161/pdf
JCI - Cellular pathophysiology of ischemic acute kidney injuryJCI - Cellular pathophysiology of ischemic acute kidney injury
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31. ... The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function. Kidney Int. 2007;72(2):151- ... Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury. Kidney Int. 2009;75(7):689- ... Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol. 2010;298(5):F1078- ...
https://www.jci.org/articles/view/45161
Trends in Hospitalizations for Acute Kidney Injury - United States, 2000-2014 | MMWRTrends in Hospitalizations for Acute Kidney Injury - United States, 2000-2014 | MMWR
CDC analysis finds a substantial increase in the rate of hospitalizations for acute kidney injury in men and women in the ... CDC analysis finds a substantial increase in the rate of hospitalizations for acute kidney injury in men and women in the ... All acute kidney injury hospitalizations and dialysis-treated acute kidney injury hospitalizations per 1,000 persons (with and ... Age-standardized rate* of hospitalization with acute kidney injury† and dialysis-treated acute kidney injury§ among men and ...
https://www.cdc.gov/mmwr/volumes/67/wr/mm6710a2.htm
Acute Kidney Injury CausesAcute Kidney Injury Causes
... , Acute Renal Failure Causes, Prerenal Failure Causes, Postrenal Failure Causes, Intrinsic Renal ... Failure Causes, Infectious Causes of Acute Interstitial Nephritis. ... Acute kidney injury, Acute Kidney Injury, Acute Renal Injuries, Renal Injury, Acute, Acute Kidney Injuries, Acute Renal Injury ... Acute Kidney Injury Acute Kidney Injury Causes Acute Kidney Injury Management Acute Kidney Injury Prognosis Acute Kidney Injury ...
https://fpnotebook.com/Renal/Failure/ActKdnyInjryCs.htm
Biomarkers identify acute kidney injury in emergency patients | EurekAlert! Science NewsBiomarkers identify acute kidney injury in emergency patients | EurekAlert! Science News
Acute kidney injury has severe consequences, with a 25 to 80 percent risk of in-hospital death. Researchers have found a way to ... Acute kidney injury (AKI) has severe consequences, with a 25 to 80 percent risk of in-hospital death. Researchers have found a ... Biomarkers identify acute kidney injury in emergency patients. Columbia University Medical Center ... "The ability to identify acute kidney damage while the patient is in triage is especially important in busy urban hospitals, ...
https://www.eurekalert.org/pub_releases/2012-01/cumc-bia010612.php
Acute Kidney Injury in Children: Being AWARE | American Academy of PediatricsAcute Kidney Injury in Children: Being AWARE | American Academy of Pediatrics
acute kidney injury. CKD - chronic kidney disease. eGFR - estimated glomerular filtration rate. KDIGO - Kidney Disease ... Acute Kidney Injury in Children: Being AWARE Message Subject (Your Name) has sent you a message from American Academy of ... Acute Kidney Injury in Children: Being AWARE. Vikas R. Dharnidharka, Eileen A. Ciccia and Stuart L. Goldstein ... Acute kidney injury (AKI) in either adults or children is associated with both short- and long-term consequences, such as ...
https://pediatrics.aappublications.org/content/146/3/e20200880?download=true
What is the AKIN classification system for acute kidney injury (AKI)?What is the AKIN classification system for acute kidney injury (AKI)?
AKIN advised that the term acute kidney injury (AKI) be used to represent the full spectrum of renal injury, from mild to ... the Acute Kidney Injury Network (AKIN) was formed. ... Acute Kidney Injury Work Group. Kidney Disease: Improving ... Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007. 11(2):R31. [ ... In September 2004, the Acute Kidney Injury Network (AKIN) was formed. AKIN advised that the term acute kidney injury (AKI) be ...
https://www.medscape.com/answers/1925597-112192/what-is-the-akin-classification-system-for-acute-kidney-injury-aki
Cellular pathophysiology of ischemic acute kidney injuryCellular pathophysiology of ischemic acute kidney injury
... and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore … ... Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components ... Cellular pathophysiology of ischemic acute kidney injury J Clin Invest. 2011 Nov;121(11):4210-21. doi: 10.1172/JCI45161. Epub ... leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury ...
https://pubmed.ncbi.nlm.nih.gov/22045571/?dopt=Abstract
v1 CH5 Acute Kidney Injuryv1 CH5 Acute Kidney Injury
Acute Kidney Injury Workgroup. KDIGO clinical practice guideline for acute kidney injury. Kidney Int 2012;2:1-138. ... Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 2014;371:58-66. ... Predicting progression to chronic kidney disease after recovery from acute kidney injury. Curr Opin Nephrol Hypertens 2012;21: ... Table A KDIGO definition and staging of acute kidney injury. Table 5.2 Characteristics of Veterans Affairs patients aged 22+ ...
https://www.usrds.org/2018/view/v1_05.aspx
Acute Kidney Injury: An OverviewAcute Kidney Injury: An Overview
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11:R31.. 12. ... of patients in the ICU develop acute kidney injury.6 Since acute kidney injury is associated with a high incidence of ... The Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) classification system divides acute kidney injury into ... ABSTRACT: Acute kidney injury is characterized by a rapid loss in kidney function with or without changes in urine output. The ...
https://www.uspharmacist.com/article/acute-kidney-injury-an-overview
The urine output definition of acute kidney injury is too liberal | SpringerLinkThe urine output definition of acute kidney injury is too liberal | SpringerLink
Introduction The urine output criterion of 0.5 ml/kg/hour for 6 hours for acute kidney injury (AKI) has not been prospectively ... Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. ... AKICr, acute kidney injury by the creatinine definition; AKIUO, acute kidney injury by the urine output definition; MAP, mean ... AKICr, acute kidney injury by the creatinine definition; AKIUO, acute kidney injury by the urine output definition; CI, ...
https://link.springer.com/article/10.1186/cc12784
Overview of the management of acute kidney injury in adultsOverview of the management of acute kidney injury in adults
Acute kidney injury (AKI) is an abrupt and usually reversible decline in the glomerular filtration rate (GFR). This results in ... in acute kidney injury in adults: Indications, timing, and dialysis dose. *Society guideline links: Acute kidney injury in ... Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int ... and Kidney and patient outcomes after acute kidney injury in adults and Possible prevention and therapy of ischemic acute ...
http://www.uptodate.com/contents/overview-of-the-management-of-acute-kidney-injury-in-adults
Acute Kidney Injuries Up Sharply in U.S. - MedicineNetAcute Kidney Injuries Up Sharply in U.S. - MedicineNet
The incidence of the most severe form of acute kidney injury increased dramatically in the United States over the past decade, ... Acute kidney injury is one of the most common and serious complications of hospitalized patients. The most severe form of acute ... Acute kidney injury refers to the abrupt or rapid decline in kidney function that can occur after serious infections, major ... The incidence of dialysis-requiring acute kidney injury is now greater than the incidence of kidney failure requiring dialysis ...
https://www.medicinenet.com/script/main/art.asp?articlekey=165786
ChronicOutcomesNephrologyCalled acute renal fTubularPatientsSevereKDIGOTreatment of acute kidneyAbruptSepsisLoss of kidneyUrineClinicalPediatric Acute KidneyMortalityDiagnosisDamage to the kidneysTreat acuteBlood flow to the kidneysFunctionIncidence of acuteFailureCases of acute kidneySymptomsBiomarkersOrgansIschemic acuteReperfusion InjuryPrerenalPreventionInterstitialTransplantComplicationsSerumDehydrationPathophysiologyRIFLEIntrinsic acute kidneyHypertensionIllnessDiabetesContrast-associated acute kidneyHospitalization with acuteCreatinineFluidComplicationInflammationMyocardial infarction2016
Chronic59
  • Chawla LS, Eggers PW, Star RA, Kimmel PL. Acute kidney injury and chronic kidney disease as interconnected syndromes. (springer.com)
  • We discuss the need for long-term follow-up of neonates with AKI to identify those children who will go on to develop chronic kidney disease. (nih.gov)
  • however, some - but not all - patients can develop long-term complications, which include high blood pressure, chronic kidney disease, and cardiovascular events," said James, a researcher at the Cumming School of Medicine at the University of Calgary. (reuters.com)
  • The doctors were more likely to recommend follow-up for patients with a history of pre-existing chronic kidney disease, heart failure, a need for acute dialysis or a less complete recovery of kidney function. (reuters.com)
  • About 20 percent of patients over age 80 and about 43 percent of patients with chronic kidney disease received follow-up care. (reuters.com)
  • It's important for people with chronic kidney disease to know that it's the most important risk for acute kidney injury and people with the condition should work with their primary doctor or nephrologist on how to prevent acute kidney injury, he said. (reuters.com)
  • If you are looking for information about long-term kidney disease, see the topic Chronic Kidney Disease . (rexhealth.com)
  • But other people may have permanent kidney damage that leads to chronic kidney disease . (rexhealth.com)
  • Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. (jci.org)
  • Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease. (jci.org)
  • It is associated with higher likelihood of long-term care, increased incidence of chronic kidney disease, increased hospital mortality, and higher health care costs. (cdc.gov)
  • Acute kidney injury (AKI) in either adults or children is associated with both short- and long-term consequences, such as increased mortality, hospitalizations, and higher risk of evolution to chronic kidney disease (CKD). (aappublications.org)
  • Risk of AKI increases with age and in the presence of comorbidities such as chronic kidney disease (CKD) and diabetes mellitus (DM). (usrds.org)
  • Among survivors, AKI is recognized as a major risk factor for the development of chronic kidney disease (CKD). (usrds.org)
  • Most of the discussion regarding the 'epidemic of kidney disease ' in the past decade or more has been focused on chronic kidney disease and end-stage [kidney] disease. (medicinenet.com)
  • Acute Kidney Injury (AKI) is associated with up to 1 in 7 secondary care admissions and is a major risk factor for multiple adverse outcomes, including a high risk of death within 30-days and long-term chronic kidney disease in those who survive. (renal.org)
  • From the authors: "These data show that while chronic cardiac injury following [myocardial infarction] protected against acute kidney injury via activation of hypoxia-sensing pathways, it worsened chronic kidney injury. (newswise.com)
  • After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and chronic kidney disease. (pnas.org)
  • We consider the long-term implications of AKI in diabetes and its potential contribution to the future development of chronic kidney disease, ESKD, and mortality. (diabetesjournals.org)
  • Chronically elevated blood levels are linked to development of Chronic Kidney Disease (CKD), a paper published by Reiser and colleagues in The New England Journal of Medicine in 2015. (rush.edu)
  • Any kidney disease, chronic or acute, genetic or acquired, is better off with a lower suPAR level. (rush.edu)
  • AKI is also a primary risk factor in the development and progression of chronic kidney disease leading to end-stage renal disease. (geisinger.edu)
  • In fact, drugs that target at least one key part of the pathway already have been studied in patients experiencing anemia - a deficiency in the red blood cells that carry oxygen - because of chronic kidney disease. (eurekalert.org)
  • One way physicians might one day improve the odds for mitochondrial and kidney survival, may be a class of drugs called PHD inhibitors, which have already been studied in chronic kidney disease. (eurekalert.org)
  • Chronic kidney disease - if your kidneys are not working perfectly in the first place and you get ill for any reason, you are more likely to get AKI than someone with perfectly normal kidneys. (kidney.org.uk)
  • For those that survive, AKI leads to an increased risk of chronic kidney disease, end-stage renal disease and mortality. (aacc.org)
  • In addition, children who survive an AKI episode are likely at risk for the development of chronic kidney disease and injury. (clinicaladvisor.com)
  • In both groups, about 20 percent of patients survived but never recovered kidney function, requiring chronic dialysis. (medgadget.com)
  • People who have experienced AKI are at increased risk of developing chronic kidney disease in the future. (wikipedia.org)
  • HONOLULU - In a liver plenary session at ACG 2015, Sujan Ravi, MD, MPH, clinical assistant professor, University of Alabama at Birmingham, presented clinical data that found acute kidney injury to be common among patients with alcoholic liver disease hospitalized for acute-on-chronic liver failure. (healio.com)
  • Alcoholic liver disease accounts for around 50% of patients with acute-on-chronic liver failure. (healio.com)
  • As we all know, acute-on-chronic liver failure in alcoholic liver disease can either be from alcoholic hepatitis or reasons other than alcoholic hepatitis. (healio.com)
  • Acute kidney injury is frequent among patients with acute-on-chronic liver failure," Ravi said during his presentation. (healio.com)
  • With this background in mind, we designed our study to examine the incidence of acute kidney injury in patients with acute-on-chronic liver failure and also evaluate the predictors of acute kidney injury among patients with acute-on-chronic liver failure. (healio.com)
  • We also tried to assess the impact of acute kidney injury in outcomes of patients with acute-on-chronic liver failure. (healio.com)
  • Ravi and colleagues, including Ashwani Singal, MD, MS, FACG, assistant professor, department of medicine, University of Alabama at Birmingham, evaluated medical charts of 104 patients with alcoholic cirrhosis meeting acute-on-chronic liver failure (ACLF) criteria and 112 patients with alcoholic hepatitis (AH) discharged from the hospital after their diagnoses. (healio.com)
  • Further guidelines will be announced in due course but are likely to include: the management of patients with interstitial lung disease and chronic kidney disease during the COVID-19 pandemic. (pharmatimes.com)
  • Prespecified subgroup analyses by renal recovery, baseline chronic kidney disease, preadmission drug regimen, and HbA 1c were performed. (diabetesjournals.org)
  • Patients with chronic kidney disease (CKD) have a higher risk of hypoglycemia and related complications ( 1 - 5 ). (diabetesjournals.org)
  • Acute kidney injury (AKI) has been reported to be on rise in both developing and developed countries and it is independently associated with increased morbidity and mortality in children and adults, as well as the subsequent development of chronic kidney disease (CKD) [ 2 ]. (omicsonline.org)
  • The primary outcome was a first diagnosis of acute kidney injury and the secondary outcome was any serious renal event (acute kidney injury or chronic kidney disease). (greenmedinfo.com)
  • Does this patient have AKI or is this chronic kidney disease (CKD)? (oncologynurseadvisor.com)
  • To treat kidney failure effectively, it is important to know whether kidney disease has developed suddenly (acute) or over the long term (chronic). (lmh.org)
  • Many conditions, diseases, and medicines can create situations that lead to acute and chronic kidney disease. (lmh.org)
  • Acute kidney injury, also called acute renal failure, is more commonly reversible than chronic kidney failure. (lmh.org)
  • Chronic kidney disease (CKD) is usually caused by a long-term disease, such as high blood pressure or diabetes , that slowly damages the kidneys and reduces their function over time. (lmh.org)
  • The presence or lack of symptoms may help your doctor determine whether acute kidney injury or chronic kidney disease is present. (lmh.org)
  • Symptoms of chronic kidney disease may not develop until very little kidney function remains. (lmh.org)
  • Other problems may develop with chronic kidney disease, such as anemia and increased levels of phosphates in the blood (hyperphosphatemia), along with complications caused by kidney failure. (lmh.org)
  • Your doctor will compare these levels to previous tests to find out if kidney disease is acute or chronic. (lmh.org)
  • An ultrasound of the kidneys also may help determine whether kidney problems are acute or chronic. (lmh.org)
  • Normal-sized kidneys may be present in either condition, but when both kidneys are smaller than normal, chronic kidney disease is usually the problem. (lmh.org)
  • http://www.ncbi.nlm.nih.gov/pubmed/8758044?tool=bestpractice.com There is controversy as to whether prior AKI is a major risk factor leading to future chronic kidney disease, but increasing evidence of strong association mounts. (bmj.com)
  • http://www.ncbi.nlm.nih.gov/pubmed/22460531?tool=bestpractice.com [220] Leung KC, Tonelli M, James MT. Chronic kidney disease following acute kidney injury: risk and outcomes. (bmj.com)
  • Osprey s DyeVert contrast minimization devices, complemented by GE Healthcare s range of iodinated x-ray contrast media, offer healthcare professionals a technology platform to address the rising problem of Acute Kidney Injury (AKI) following interventional coronary angiograms in patients with Chronic Kidney Disease (CKD). (webwire.com)
  • Since children who survive AKI are at risk for developing chronic kidney disease, long-term follow up of these survivors is warranted. (cincinnatichildrens.org)
  • In certain cases usually as a result of diabetes or high blood pressure loss of function can be extreme and lead to chronic kidney disease. (healthcommunities.com)
  • Chronic kidney disease develops over months or years sometimes silently and affects more than 20 million Americans. (healthcommunities.com)
  • Patients who have chronic renal failure (CRF) also are at increased risk for suffering acute kidney injury. (healthcommunities.com)
Outcomes32
  • Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. (springer.com)
  • What Do We Know About Long-term Kidney Outcomes in Neonatal Survivors? (nih.gov)
  • In recent years, there have been significant advancements in our understanding of acute kidney injury (AKI) and its impact on outcomes across medicine. (nih.gov)
  • We put forth and describe the neonatal modified Kidney Diseases: Improving Global Outcomes AKI criteria and provide the rationale for its use as the standardized definition of neonatal AKI. (nih.gov)
  • In an effort to begin to address these needs, the Neonatal Kidney Collaborative was formed in 2014 with the goal of better understanding neonatal AKI, beginning to answer critical questions, and improving outcomes in these vulnerable populations. (nih.gov)
  • Early assessment for acute kidney injury when making decisions about treatment for people who are at risk may prevent delays in treating the condition, leading to improved outcomes. (nice.org.uk)
  • Global epidemiology and outcomes of acute kidney injury. (nih.gov)
  • With the harmonization of other definitions into one globally accepted definition through the Kidney Disease Improving Global Outcomes (KDIGO) 2012 AKI criteria, 3 more recent studies are now more comparable, but we still have challenges in collecting enough large-scale data for children. (aappublications.org)
  • A Comparison of Traditional and Novel Definitions (RIFLE, AKIN, and KDIGO) of Acute Kidney Injury for the Prediction of Outcomes in Acute Decompensated Heart Failure. (medscape.com)
  • Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. (medscape.com)
  • Fujii T, Uchino S, Takinami M, Bellomo R. Validation of the Kidney Disease Improving Global Outcomes criteria for AKI and comparison of three criteria in hospitalized patients. (medscape.com)
  • Among hospitalized veterans aged 22+ years, 25.4% met Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for AKI as defined using serum creatinine-based criteria (Table A). This included 21.4%, 0.8%, and 3.2% of patients with Stage 1, Stage 2, and Stage 3 AKI (Table 5.2). (usrds.org)
  • See 'Diagnostic approach to adult patients with subacute kidney injury in an outpatient setting' and 'Kidney and patient outcomes after acute kidney injury in adults' and 'Possible prevention and therapy of ischemic acute tubular necrosis' . (uptodate.com)
  • They also report they found no evidence that factors such as the amount of time an organ is chilled and left without blood supply before transplantation had any impact on recipient outcomes for those who received AKI kidneys. (hopkinsmedicine.org)
  • Using the Kidney Disease: Improve Global Outcomes creatinine criteria, inpatients at several hospitals will be randomized to usual care versus electronic alerting. (clinicaltrials.gov)
  • Acute Kidney Injury has been identified as a global priority for improving patient safety and health outcomes. (rcgp.org.uk)
  • Researchers found no significant difference in death rates or other outcomes between patients with acute kidney injury that received intensive dialysis or those who received a more standard regimen of dialysis. (nih.gov)
  • Failure to recognize and manage acute kidney injury in the early stages can lead to devastating outcomes for patients and increased costs to the health care system. (eurekalert.org)
  • We conducted a study to evaluate the incidence, risk factors and outcomes associated with early acute kidney injury (AKI) in sepsis. (unboundmedicine.com)
  • Our findings demonstrate that urinary NGAL is an excellent predictor of acute kidney injury and predicts clinical outcomes. (aacc.org)
  • Diuretics do not improve morbidity, mortality, or renal outcomes, and should not be used to prevent or treat acute kidney injury in the absence of volume overload. (aafp.org)
  • the hope is that outcomes might be improved with the use of a bioengineered device which more closely replicates the functions of the human kidney. (medgadget.com)
  • The definition of AKI is outlined below, according to the KDIGO (Kidney Disease: Improving Global Outcomes) Clinical Practice Guideline for Acute Kidney Injury. (uspharmacist.com)
  • Patients who experience hypoglycemia are at an increased risk of major adverse clinical outcomes, such as poor quality of life, acute and long-term neurological impairment, acute cardiovascular events, and death ( 1 - 3 ). (diabetesjournals.org)
  • Theoretically, early removal of toxins and excess water from the bloodstream might improve patient outcomes (such as death rate and recovery of kidney function). (cochrane.org)
  • Based mainly on low quality of evidence identified, early RRT may reduce the risk of death and may improve the recovery of kidney function in critically patients with AKI, however the 95% CI indicates that early RRT might worsen these outcomes. (cochrane.org)
  • Long-term risk of mortality and other adverse outcomes after acute kidney injury: systematic review and meta-analysis. (bmj.com)
  • Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. (bmj.com)
  • OAKLAND, Calif.--( BUSINESS WIRE )--Dascena, Inc., a machine learning diagnostic algorithm company that is targeting early disease intervention to improve patient care outcomes, today announced it has received Breakthrough Device Designation from the U.S. Food and Drug Administration (FDA) for Previse , the company's algorithm designed to predict acute kidney injury (AKI) more than a full day before patients meet the clinical criteria for diagnosis. (businesswire.com)
  • Acute kidney injury commonly affects hospitalized individuals, and if not caught early, can result in dangerous outcomes for patients," said Ritankar Das, chief executive officer of Dascena. (businesswire.com)
  • Patients with impaired kidneys are at a significantly increased risk for negative outcomes and for longer hospital stays (3). (webwire.com)
  • Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions. (webwire.com)
Nephrology15
  • It's estimated that 500 of every 100,000 adults in North America, or around 1.4 million people, are hospitalized with acute kidney disease each year, James and his colleagues write in the Clinical Journal of the American Society of Nephrology. (reuters.com)
  • There is a substantial disparity between the opinions of nephrologists and actual processes of care for nephrology evaluation of patients after hospitalization with acute kidney, James said. (reuters.com)
  • However, nearly all patients who did not receive nephrology follow-up were seen by at least one other physician within a year of discharge, suggesting there are other opportunities for physicians to follow-up and improve care for patients that have had acute kidney injury," he told Reuters Health. (reuters.com)
  • Medicare data show similarly low rates of nephrology referral after hospitalization for dialysis-requiring acute kidney disease in the U.S., noted Dr. Joseph A. Vassalotti, chief medical officer of the National Kidney Foundation, who wasn't involved in the study. (reuters.com)
  • The term AKI, rather than acute renal failure (ARF), is increasingly used by the nephrology community to refer to the acute loss of kidney function. (uptodate.com)
  • The number of deaths associated with dialysis-requiring acute kidney injury increased from 18,000 in 2000 to nearly 39,000 in 2009, according to the study released Dec. 6 in advance of publication in an upcoming issue of the Journal of the American Society of Nephrology . (medicinenet.com)
  • We want to point out that acute kidney injury is equally important," study author Dr. Chi-yuan Hsu, of the University of California, San Francisco, said in a news release from the American Society of Nephrology. (medicinenet.com)
  • The results, published today in the Journal of the American Society of Nephrology , address one of the most costly and deadly conditions affecting hospitalized patients, providing evidence that computers analyzing changes in renal function can alert doctors of acute kidney injury before the condition is obvious clinically. (eurekalert.org)
  • Acute kidney injury strikes one in eight hospitalized patients and, if unchecked, it can lead to serious complications, including the need for dialysis and even death," said senior author John Kellum, M.D., professor of critical care medicine and director of the Center for Critical Care Nephrology at Pitt's School of Medicine. (eurekalert.org)
  • Dr. Jonathan Barasch, a nephrology expert at Columbia University, will discuss the different types of Acute Kidney Injury and its biomarkers as well as the mechanisms associated with COVID-19. (acmt.net)
  • International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. (prnewswire.co.uk)
  • Nearly 1 in 10 patients initiating systemic cancer therapy will experience a hospitalization or receive acute dialysis for acute kidney injury," Abhijat Kitchlu , MD, FRCPC, of the department of medicine and division of nephrology at University of Toronto, and colleagues wrote. (healio.com)
  • The study Temporal Trends in Acute Kidney Injury across Healthcare Settings in the Irish Health System: A Cohort Study is published by Nephrology Dialysis Transplantation and authored by Austin G Stack, Xia Li, Mohamed Kaballo, Mohamed E Elsayed, Howard Johnson, Patrick Murray, Rajiv Saran, Leonard D Browne. (ul.ie)
  • Moreover, the nearly 12 percent who develop more severe AKI have a further increased risk of death within 28 days, according to lead author Stuart L. Goldstein, MD , director of the Center for Acute Care Nephrology at Cincinnati Children's . (cincinnatichildrens.org)
  • The AWARE (Assessment of Worldwide AKI, Renal angina and Epidemiology in children) study was coordinated by the Center for Acute Care Nephrology at Cincinnati Children's. (cincinnatichildrens.org)
Called acute renal f5
  • Acute (sudden) kidney injury, formerly called acute renal failure, occurs when a kidney is damaged suddenly due to an illness or condition - not because of a blow or injury to a kidney as the name might suggest. (childrens.com)
  • Acute kidney injury (which used to be called acute renal failure) means that your kidneys have suddenly stopped working normally. (rexhealth.com)
  • Acute kidney injury, also called acute renal failure, is a common complication in hospitalized patients. (nih.gov)
  • Intrinsic or intrarenal acute kidney injury (AKI) , which used to be called acute renal failure, occurs when direct damage to the kidneys causes a sudden loss in kidney function. (wellspan.org)
  • Acute kidney injury (AKI), previously called acute renal failure (ARF), is a sudden decrease in kidney function that develops within 7 days, as shown by an increase in serum creatinine or a decrease in urine output, or both. (wikipedia.org)
Tubular25
  • The injury induces the generation of inflammatory mediators like cytokines and chemokines by tubular and endothelial cells which contribute to the recruiting of leukocytes into the kidneys. (hindawi.com)
  • As a result of this imbalance, the tubular epithelial cells undergo injury and, if it is severe, death by apoptosis and necrosis (acute tubular necrosis [ATN]), with organ functional impairment of water and electrolyte homeostasis and reduced excretion of waste products of metabolism. (jci.org)
  • Acute tubular necrosis, the most common type of intrinsic acute kidney injury in hospitalized patients, is typically caused by ischemia or nephrotoxicity. (uspharmacist.com)
  • 16 While tubular cells usually can regulate their processes and survive in an ischemic environment, factors that reduce the supply of metabolites to these cells can cause acute tubular necrosis. (uspharmacist.com)
  • In most cases, patients with acute tubular necrosis will experience a reduction in urine output. (uspharmacist.com)
  • Acute tubular necrosis does not improve with adequate repletion of intravascular volume and blood flow to the kidneys. (uspharmacist.com)
  • However, ischemic and nephrotoxic acute tubular necrosis will resolve over time, although some patients may require temporary renal replacement therapy. (uspharmacist.com)
  • Among hospitalized patients, AKI is most commonly due to either prerenal etiologies (volume depletion, 'third spacing,' effective volume depletion from heart failure or cirrhosis) or acute tubular necrosis (ATN) from ischemia, nephrotoxin exposure, or sepsis [ 1 ]. (uptodate.com)
  • See 'Pathogenesis and etiology of ischemic acute tubular necrosis' and 'Pathogenesis, clinical features, and diagnosis of contrast-induced nephropathy' . (uptodate.com)
  • See 'Etiology and diagnosis of prerenal disease and acute tubular necrosis in acute kidney injury in adults' and 'Clinical manifestations and diagnosis of urinary tract obstruction and hydronephrosis' and 'Overview of the classification and treatment of rapidly progressive (crescentic) glomerulonephritis' and 'Clinical manifestations and diagnosis of acute interstitial nephritis' . (uptodate.com)
  • 10 The experimental data demonstrated that the mechanisms involved in the pathogenesis of RIAKI included direct injuries on tubular cells by iron release and oxidative stress from myoglobin, as well as indirect damages of subsequent renal vasoconstriction and tubular hypoxia. (nature.com)
  • The histological results were: partial cortical necrosis in one case, thrombotic microangiopathy in two cases, acute tubular necrosis in one case, and membranoproliferative glomerulonephritis in one case. (scirp.org)
  • The most common causes of intrinsic acute kidney injury are acute tubular necrosis (ATN), acute glomerulonephritis (AGN), and acute interstitial nephritis (AIN) . (wellspan.org)
  • Acute tubular necrosis (ATN) is a condition in which the small filtering tubes in the kidney are injured. (wellspan.org)
  • When kidney blood flow reaches approximately 20% of normal, damage can occur to tubular cells (Porth, 2007). (thefreelibrary.com)
  • The "renal assist device" (RAD) is a bioartificial kidney - a device lined with human renal tubular cells grown from donated organs. (medgadget.com)
  • Intrinsic renal causes of AKI include glomerulonephritis, lupus nephritis, acute tubular necrosis, certain antibiotics, chemotherapeutic agents, and contrast dye used for imaging. (wikipedia.org)
  • The mechanism of kidney injury may be due to hemodynamic effects, tubular or glomerular toxicity, and interstitial nephritis. (uspharmacist.com)
  • Tubular epithelial cell and granular "muddy brown" casts are often seen on urine microscopy, as CA-AKI represents a form of acute tubular necrosis. (renalandurologynews.com)
  • Pre-renal AKI responds to intravascular volume administration, whereas established acute tubular necrosis from intravascular contrast administration does not respond to therapeutic intravascular volume expansion. (renalandurologynews.com)
  • Histone crotonylation was studied in cultured murine proximal tubular cells and in kidneys from mice with AKI induced by folic acid or cisplatin. (biologists.org)
  • Histone lysine-crotonylation was observed in tubular cells from healthy murine and human kidney tissue. (biologists.org)
  • Specifically, ChIP-seq disclosed enrichment of histone crotonylation at the genes encoding the mitochondrial biogenesis regulator PGC-1α and the sirtuin-3 decrotonylase in both TWEAK-stimulated tubular cells and in AKI kidney tissue. (biologists.org)
  • To assess the role of crotonylation in kidney injury, crotonate was used to increase histone crotonylation in cultured tubular cells or in the kidneys in vivo. (biologists.org)
  • Crotonate increased the expression of PGC-1α and sirtuin-3, and decreased CCL2 expression in cultured tubular cells and healthy kidneys. (biologists.org)
Patients103
  • Acute kidney injury is probably the most frequent syndrome observed in critically ill patients carrying significant implications with regard to morbidity, mortality as well as long term outcome. (biomedcentral.com)
  • Acute kidney injury (AKI) complicates recovery from cardiac surgery in up to 30 % of patients, injures and impairs the function of the brain, lungs, and gut, and places patients at a 5-fold increased risk of d. (biomedcentral.com)
  • Acute renal failure in critically ill patients: a multinational, multicenter study. (springer.com)
  • RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. (springer.com)
  • Acute kidney injury (AKI) occurs in 1% of hospital admissions [ 1 ] and up to 7% of hospitalized patients develop AKI [ 1 ]. (hindawi.com)
  • In March 2012, the Wyoming Department of Health was notified by Natrona County public health officials regarding three patients hospitalized for unexplained acute kidney injury (AKI), all of whom reported recent use of synthetic cannabinoids (SCs), sometimes referred to as "synthetic marijuana. (cdc.gov)
  • Reuters Health) - Kidney specialists recommend follow-up care for most patients who have experienced acute kidney injury, but only a minority of patients have been getting that care, according to a Canadian study. (reuters.com)
  • Acute kidney injury refers to a sudden loss of kidney function that usually develops over the course of days in patients who are hospitalized for a wide variety of conditions," senior author Dr. Matthew James told Reuters Health by email. (reuters.com)
  • The researchers then looked at how many patients hospitalized with acute kidney injury in the province of Alberta between 2005 and 2014 actually did have follow-up care from a nephrologist. (reuters.com)
  • But, the researchers discovered, only 24 percent of actual patients were seen by a nephrologist in Alberta within one year of being hospitalized with acute kidney injury. (reuters.com)
  • Full recovery of kidney function is uncommon, which leaves these patients at risk of long-term morbidity and death. (nih.gov)
  • They discovered that the patients who had undergone major surgery and were therefore prone to developing acute kidney injury had high levels of quinolinate in their urine. (medicalnewstoday.com)
  • Our results," explains study co-author Dr. Kamal Khabbaz, the chief of cardiac surgery at the CardioVascular Institute at the BIDMC, "suggest that NAD+ biosynthesis becomes impaired during human acute kidney injury and that augmenting vitamin B-3 levels may be safe and potentially beneficial to patients. (medicalnewstoday.com)
  • Restoring NAD+ could constitute an important advance for patients at risk for acute kidney injury, though further studies are needed to verify these findings," concludes Dr. Khabbaz. (medicalnewstoday.com)
  • Combining urinary biomarkers such as uNGAL with the current standard marker creatinine will significantly improve the identification of patients at risk of death or dialysis in the hospital," added Dr. Kai Schmidt-Ott, MD, a kidney specialist at Charité Berlin, research group leader at the Max Delbrück Center for Molecular Medicine, and adjunct assistant professor at Columbia University Medical Center. (eurekalert.org)
  • Ratanarat R, Skulratanasak P, Tangkawattanakul N, Hantaweepant C. Clinical accuracy of RIFLE and Acute Kidney Injury Network (AKIN) criteria for predicting hospital mortality in critically ill patients with multi-organ dysfunction syndrome. (medscape.com)
  • Acute kidney injury (AKI) is a common complication among hospitalized patients, and is associated with substantial morbidity and mortality. (usrds.org)
  • The initial management of all patients with acute kidney injury should be supportive and should aim to prevent further injury. (uspharmacist.com)
  • 1,4,5 It has been shown that 7% of hospitalized patients and as many as 67% of patients in the ICU develop acute kidney injury. (uspharmacist.com)
  • Other frequent causes of AKI among either ambulatory or hospitalized patients include volume depletion, urinary obstruction, rapidly progressive glomerulonephritis, and acute interstitial nephritis. (uptodate.com)
  • Acute kidney injury is one of the most common and serious complications of hospitalized patients. (medicinenet.com)
  • Is there a protective effect with remote ischemic preconditioningon contrast-induced acute renal injury after coronaryangiography in low-risk patients? (magiran.com)
  • The question is why kidney is super-sensitive to the infection in selected patients with COVID-19? (bmj.com)
  • Acute kidney injury in SARS-CoV-2 infected patients. (bmj.com)
  • I read with interest the summary of NICE guidelines for the prevention and management of acute kidney injury (AKI) in COVID-19 patients (1). (bmj.com)
  • Acute kidney injury (AKI) in critically ill trauma patients has been shown to significantly increase mortality, length of stay, and costs, however detection has proven difficult as markers like elevated creatinine and decreased urine output may take days to manifest and are late indicators of AKI. (clinicaltrials.gov)
  • Therefore, the investigators plan to assess if acute kidney injury in critically ill trauma patients can be determined earlier using urinary TIMP-2 and IGFBP-7 via the NephroCheck testing system. (clinicaltrials.gov)
  • Subjects must be trauma patients with multiple injuries. (clinicaltrials.gov)
  • Acute kidney injury (AKI) carries a significant, independent risk of mortality among hospitalized patients. (clinicaltrials.gov)
  • The trial, which randomized 2400 patients with AKI as defined by an increase in creatinine of 0.3mg/dl over 48 hours or 50% over 7 days, found that alerting physicians to the presence of AKI did not improve the course of acute kidney injury, reduce dialysis or death rates. (clinicaltrials.gov)
  • In the present proposal, the investigators seek to expand upon their prior study to determine both the modes of alerting that would be most effective and to determine if targeting alerts (such as to patients on medications that may worsen acute kidney injury) will improve effectiveness. (clinicaltrials.gov)
  • Up to 10% of patients who are hospitalized or undergo surgery will experience acute kidney injury (AKI), and as many as 50% of patients in intensive care units will meet the criteria for AKI, the National Kidney Foundation has determined. (rush.edu)
  • Some of these patients will progress to kidney failure within months. (rush.edu)
  • By looking at suPAR levels in patients, we can possibly prevent damage to healthy kidneys that is often irreversible. (rush.edu)
  • We collected blood samples from patients about to undergo coronary angiography for suspected heart disease, patients undergoing cardiac surgery, and critically ill patients who had been admitted to the intensive care unit," said David E. Leaf, MD, a co-first author on the study and the director acute kidney injury research at Brigham and Women's Hospital of Harvard Medical School. (rush.edu)
  • 2020 Nov;42(1):154-165 Authors: Oh DJ Abstract Acute kidney injury (AKI) is a life-threatening illness that continues to have an in-hospital mortality rate of patients with AKI ranges from 20% to 50% or greater, depending on underlying conditions. (medworm.com)
  • Ziting Wang, Pradeep Durai, Ho Yee TiongIndian Journal of Urology 2020 36(2):89-94There is an increasing gulf between demand and supply for kidneys in end-stage renal failure patients worldwide, especially Asia. (medworm.com)
  • A research team led by Kevin Ho, Sara Saunders, Les Kirchner, Andres Garcia-Arce, and Becky Stametz is funded by Quality Fund award from the Geisinger Health Plan to develop and implement over 2-3 years a novel mechanism to improve the care of all patients at risk for and/or developing acute kidney injury (AKI), a major cause of mortality, when admitted to Geisinger Medical Center. (geisinger.edu)
  • No effective medications have been found to treat acute kidney injury, so doctors use hemodialysis and other forms of renal-replacement therapy to support patients whose kidneys don't function properly. (nih.gov)
  • Smaller studies in the past had suggested that intensive dialysis, which is significantly more costly to administer than standard care, improves survival in patients with acute kidney injury. (nih.gov)
  • The Acute Renal Failure Trial Network study set out to see if intensive therapy could reduce the death rate, shorten the duration of illness and decrease the number of new complications in other organs among patients with acute kidney injury. (nih.gov)
  • There were no significant differences between the 2 groups in recovery of kidney function, the rate of failure of organs other than kidneys or the number of patients able to return to their prior living situations. (nih.gov)
  • Our analysis shows that implementation of a clinical decision support system was associated with lower mortality, less need for dialysis and reduced length of hospital stay for patients diagnosed with acute kidney injury, among other benefits. (eurekalert.org)
  • Acute kidney injury is common in hospitalized patients, particularly those in intensive care units and older adults, and refers to a sudden episode of kidney failure or damage that happens within a few hours or days. (eurekalert.org)
  • Patients with acute kidney injury had a small yet sustained decrease in hospital mortality of 0.8 percent, 0.3-day shorter length of stay and a decrease of 2.7 percent in dialysis rates. (eurekalert.org)
  • In absolute terms, the changes are small, but given the annual frequency of acute kidney injury in hospitalized U.S. patients of about 12 percent - or 2.2 million people - these results would translate into more than 17,000 lives and $1.2 billion saved per year. (eurekalert.org)
  • They found one, microRNA-668, consistently elevated in both patients with an acute kidney injury as well as animal models of the condition, which is common in patients in intensive care, particularly older patients. (eurekalert.org)
  • PHD - prolyl hydroxylase - is a protein that induces the degradation of protective HIF-1 and Dong suspects PHD inhibitors could benefit patients with acute kidney injury as well. (eurekalert.org)
  • Run by kidney patients, for kidney patients. (kidney.org.uk)
  • This study examined the incidence and etiology of acute kidney injury in pregnancy, the morbidity, fetomaternal mortality, and renal prognosis among pregnant patients developing acute kidney injury. (scirp.org)
  • Five patients underwent renal biopsy for a persistent acute kidney injury with an average delay of 26 days. (scirp.org)
  • For septic AKI stratified by RIFLE (risk of renal failure, injury to the kidney, failure of kidney function, loss of kidney function and end-stage kidney disease) category, 38.5% of patients belonged to the risk category, 38.8% to the injury category and 22.7% to the failure category. (unboundmedicine.com)
  • Patients with septic AKI are generally sicker, with a higher burden of illness, and have greater abnormalities in acute physiology compared with patients with nonseptic AKI. (unboundmedicine.com)
  • Doctors need to monitor patients regularly for kidney function if they are taking tenofovir disoproxil, especially if combined with ritonavir, the 9th International AIDS Society Conference on HIV Science (IAS 2017) heard this week. (aidsmap.com)
  • Importantly, it could appear unexpectedly, in patients with no characteristics linked to kidney disease. (aidsmap.com)
  • One average, patients had normal kidney function when they started tenofovir (eGFR = 106) and only 2.5% had kidney malfunction as defined by an eGFR below 50 (1.6% of those also taking ritonavir). (aidsmap.com)
  • All these cases could have been spotted with a cheap urine dipstick test at every HIV checkup," said Dr Medland, urging continued monitoring even in patients with perfectly normal kidney function. (aidsmap.com)
  • Acute kidney injury (AKI) greatly increases patients' risk for in-hospital death, and its incidence is increasing. (aacc.org)
  • However, emergency physicians face a challenge in quickly triaging patients because serum creatinine (sCr), the current standard for assessing kidney function, can take hours or days to respond to acute kidney damage. (aacc.org)
  • We chose the ED because we felt that a good biomarker should be able to detect acute kidney injury in a broad range of patients in a real world environment. (aacc.org)
  • In a cohort of 1,635 emergency room patients from the U.S. and the Helios Clinics in Berlin, the researchers took a single measure of five urinary biomarkers: uNGAL, kidney injury molecule-1 (KIM-1), urinary liver-type fatty acid binding protein, urinary interleukin-18, and cystatin C. All of the biomarkers were elevated in cases of intrinsic AKI (iAKI), a term that indicates severe, cellular level kidney damage. (aacc.org)
  • We don't have a drug or intervention that once patients have a low level of kidney injury, we can just turn that around. (aacc.org)
  • Acute kidney injury (AKI) is a common multifactorial syndrome in hospitalized patients. (clinicaltrials.gov)
  • In this trial, patients with acute kidney injury who have recently received a drug that may affect kidney function will be randomized to having an alert placed in the electronic health record or usual care. (clinicalconnection.com)
  • Ultrasonography of the kidneys should be performed in most patients, particularly in older men, to rule out obstruction. (aafp.org)
  • 3 Seven percent of hospitalized patients and about two-thirds of patients in intensive care units develop acute kidney injury, 2 often as part of the multiple organ dysfunction syndrome. (aafp.org)
  • Renal ultrasonography should be performed in most patients with acute kidney injury to rule out obstruction. (aafp.org)
  • Adequate fluid balance should be maintained in patients with acute kidney injury by using isotonic solutions (e.g., normal saline) instead of hyperoncotic solutions (e.g., dextrans, hydroxyethyl starch, albumin). (aafp.org)
  • There has been lots of anecdotal evidence suggesting these drugs may be a contributory factor in patients developing acute kidney injury, and this work gives us an opportunity to estimate the size of the problem, as well as making clinicians and patients more aware of the importance of using these drugs in accordance with current clinical guidelines. (bloodpressureuk.org)
  • Patients in the RAD group also had a shorter time to return of kidney function. (medgadget.com)
  • Overall, kidney function recovered in 53 percent of patients with RAD, compared to 28 percent without RAD. (medgadget.com)
  • In regards to risk, they cited the identification of high-risk patients as particularly relevant in the hospital setting, as it would allow physicians to intervene in order to potentially prevent kidney injury. (prnewswire.co.uk)
  • Acute kidney injury occurs in up to 30% of patients following cardiac surgery. (wikipedia.org)
  • Overall, 70% of all 216 patients presented with acute kidney injury (AKI) at admission or during hospitalization (n = 151). (healio.com)
  • Acute kidney injury appeared to be a common and considerable burden among patients receiving systemic treatment for cancer, according to a population-based study published in Journal of the National Cancer Institute . (healio.com)
  • This magnitude of acute kidney injury risk may be underappreciated by both clinicians and patients commencing systemic cancer treatment, given the paucity of existing data. (healio.com)
  • A total of 10,880 patients in the cohort experienced acute kidney injury over 403,530 patient-years of follow-up. (healio.com)
  • Patients with myeloma who received a bortezomib-based treatment regimen had a decreased risk for acute kidney injury, according to researchers. (healio.com)
  • They added that the increased risk for acute kidney injury among patients with bladder and cervical cancers could be a result of exposure to nephrotoxic platinum-based chemotherapies, whereas the higher risk in leukemias and other hematological cancers may be attributable to the risks for sepsis, volume depletion and tumor lysis syndrome. (healio.com)
  • Limitations of this study included a lack of serum creatinine data and a lack of data surrounding acute kidney injury among patients who were not hospitalized, which could have led to an underestimation of the overall incidence of injury. (healio.com)
  • According to the Institute, the guideline is designed to help healthcare professionals who are not kidney specialists to prevent, detect and manage AKI in patients in hospital with suspected or confirmed COVID-19. (pharmatimes.com)
  • There is also emerging evidence that suggests the coronavirus might directly harm the kidneys, it said, highlighting the need for patients to be assessed for AKI on admission to hospital or transfer, monitored for AKI throughout their stay and AKI is managed appropriately if it develops. (pharmatimes.com)
  • Patients with acute renal failure should receive H2-blockers. (edren.org)
  • Rates of Acute Kidney Injury among Irish patients have more than doubled in the past 10 years, according to a new study led by researchers at the Graduate Entry Medical School (GEMS), University of Limerick. (ul.ie)
  • In the long term, patients who suffer an AKI are more prone to kidney failure and early death. (ul.ie)
  • Dr Leonard Browne, senior author of the study and research fellow said, "The increase in AKI could in part be explained by an increase in the number of elderly patients in the health system and a larger proportion of patients with poorer kidney function. (ul.ie)
  • Acute Kidney Injury is a significant problem and puts patients at risk of kidney failure. (ul.ie)
  • This review explores the potential causes of haematuria and acute kidney injury in patients receiving warfarin treatment. (omicsonline.org)
  • Compared to standard, early initiation of RRT may reduce the risk of death, may increase the recovery of kidney function, or increase the risk of adverse events in patients with AKI in intensive care units. (cochrane.org)
  • Acute kidney injury (AKI) is a common condition among patients in intensive care units (ICUs), and is associated with high death. (cochrane.org)
  • To assess the effects of different timing (early and standard) of RRT initiation on death and recovery of kidney function in critically ill patients with AKI. (cochrane.org)
  • Patients with rheumatoid arthritis found a significantly increased risk of acute kidney injury associated with the use of proton pump inhibitors. (greenmedinfo.com)
  • Use of Proton Pump Inhibitors and the Risk of Acute Kidney Injury Among Patients with Rheumatoid Arthritis: Cohort Study. (greenmedinfo.com)
  • The objective of this study was to investigate whether the use of proton pump inhibitors increases the risk of acute kidney injury among patients with rheumatoid arthritis. (greenmedinfo.com)
  • All of these tests should be considered in patients with acute renal failure. (edren.org)
  • The list applies also to patients with a lesser degree of renal impairment who have an acute or immunological renal illness. (edren.org)
  • Acute kidney injury and mortality in hospitalized patients. (bmj.com)
  • With this technology, we believe we'll be able to provide physicians with ample time to intervene and prevent long-term kidney injury in their patients. (businesswire.com)
  • Previse is an algorithm that continuously monitors hospitalized patients and can predict acute kidney injury more than a full day before patients meet the clinical criteria for diagnosis, providing clinicians with ample time to intervene and prevent long-term injury. (businesswire.com)
  • Osprey s President and CEO, Mike McCormick, stated: We are pleased to be partnering with GE Healthcare to commercialize our products in global markets to address the rising problem of AKI following heart imaging procedures in patients with poor kidney function. (webwire.com)
  • Osprey Medical s vision is to make heart imaging procedures safer for patients with poor kidney function. (webwire.com)
  • The common and early occurrence of acute kidney injury reinforces the need for systematic surveillance for AKI at the time patients are admitted to intensive care," says Goldstein. (cincinnatichildrens.org)
  • The new test, called NephroCheck, allows for closer monitoring of patients at high risk for developing AKI in the 12 hours following administration of the test helping to prevent permanent kidney damage. (healthcommunities.com)
Severe20
  • There are many possible causes of kidney injury, including low blood pressure, heart failure or failure of other organs, overuse of NSAID painkillers, burns, major surgery and severe allergic reactions, according to the U.S. National Kidney Foundation. (reuters.com)
  • Acute kidney injury (AKI) has severe consequences, with a 25 to 80 percent risk of in-hospital death. (eurekalert.org)
  • The severity of the condition ranges from mild to severe, and the type of acute kidney injury is based upon the causative agent. (uspharmacist.com)
  • Acute kidney injury has an estimated incidence of two to three cases per 1,000 persons, which is higher than the incidence of conditions such as acute lung injury and severe sepsis. (uspharmacist.com)
  • FRIDAY, Dec. 7 (HealthDay News) -- The incidence of the most severe form of acute kidney injury increased dramatically in the United States over the past decade, and deaths associated with the condition doubled over that time, a new study says. (medicinenet.com)
  • The most severe form of acute kidney injury requires dialysis . (medicinenet.com)
  • 1 As a severer clinical condition, rhabdomyolysis can be caused by a broad range of physical or chemical damages such as trauma, physical exertion, infections, drugs and toxins, etc. 2 Acute kidney injury (AKI) is a life-threatening complication of severe rhabdomyolysis and their association was first described during the World War II. (nature.com)
  • The kidneys are vulnerable organs that endure severe illnesses and treatments. (rug.nl)
  • Acute kidney injury (AKI) is increasingly prevalent in China and is associated with severe morbidity and mortality. (ovid.com)
  • Now, the new paper is showing that having elevated suPAR levels is also a risk factor for acute kidney injury - a sudden decline in kidney function that can be a severe side effect of general medical procedures. (rush.edu)
  • Benefits of earlier detection of acute kidney injury include earlier intervention to mitigate loss of kidney function, and reduced hospital and long-term health care costs as a result of avoiding progression to severe and permanent kidney damage. (eurekalert.org)
  • Acute' does not always mean that a problem is severe, just that it developed recently. (kidney.org.uk)
  • Dehydration - severe dehydration will reduce the blood flow to the kidneys. (kidney.org.uk)
  • Drakeley, A.J., Le Roux, P.A., Anthony, J. and Penny, J. (2002) Acute Renal Failure Complicating Severe Preeclampsia Requiring Admission to an Obstetric Intensive Care Unit. (scirp.org)
  • Severe muscle injury or extreme physical exertion. (wellspan.org)
  • There are many causes of AKI such as severe dehydration, acute illnesses like pneumonia, blood loss or even certain medications like anti-inflammatory drugs. (ul.ie)
  • AKI can range in severity from mild (Stage 1) to severe (Stage 3), where severe forms are more likely to cause kidney failure and require dialysis. (ul.ie)
  • Severe AKI was associated with an increased need for mechanical ventilation to assist breathing, and with renal replacement therapy (acute dialysis). (cincinnatichildrens.org)
  • AKI develops quickly, causing a sudden and severe drop in kidney function . (healthcommunities.com)
  • By the time damage is discovered, it can be severe enough to require dialysis permanently or, if caught early enough, only temporarily until the kidneys heal and return to normal function. (healthcommunities.com)
KDIGO1
  • The objective of this conference is to identify areas where knowledge has significantly advanced since the publication of the 2012 KDIGO Acute Kidney Injury (AKI) Guideline and to outline existing controversies in diagnosis and management of AKI in order to lay the foundation for a future targeted revision of that guideline. (kdigo.org)
Treatment of acute kidney2
  • The treatment of acute kidney injury (AKI) prior to institution of renal replacement therapy (RRT) has traditionally focused on the management of life-threatening metabolic abnormalities in advanced kidney failure. (springer.com)
  • The finding that intensive treatment of acute kidney injury is no more beneficial than the usual level of care may help to prevent unnecessary medical expenditures. (nih.gov)
Abrupt9
  • Acute kidney injury (AKI) is an abrupt and usually reversible decline in the glomerular filtration rate (GFR). (uptodate.com)
  • Acute kidney injury refers to the abrupt or rapid decline in kidney function that can occur after serious infections, major surgery or taking certain medications. (medicinenet.com)
  • AKI is a complex disorder with varying definitions, most including an abrupt decline in kidney function leading to a rise in serum creatinine and/or blood urea nitrogen levels, with or without a decrease in urine output (ADIS International Ltd., 2009, Barrantes et al. (thefreelibrary.com)
  • Acute kidney injury is characterized by abrupt deterioration in kidney function, manifested by an increase in serum creatinine level with or without reduced urine output. (aafp.org)
  • Description of the problem: AKI in the child/newborn is defined as an abrupt cessation or diminution of kidney function. (clinicaladvisor.com)
  • Acute kidney injury (previously known as acute renal failure) is an abrupt decline in renal excretory function characterized by a reversible increase in the blood concentration of creatinine and nitrogenous waste products often with decrease in urine output and by the inability of the kidney to regulate fluid and electrolyte homeostasis [ 1 ]. (omicsonline.org)
  • Contrast-associated acute kidney injury (CA-AKICA-AKI) is characterized by an abrupt decline in kidney function following the intravascular administration of iodinated contrast media. (renalandurologynews.com)
  • Acute kidney injury (AKI), formerly acute renal failure, refers to an abrupt (within 48 hours) reduction in kidney function leading to azotemia. (oncologynurseadvisor.com)
  • AKI causes an abrupt and dramatic drop in the kidneys' filtering capacity , causing waste products and fluid to accumulate in the blood, which can occur over a period of days or hours. (healthcommunities.com)
Sepsis7
  • Endothelial activation and damage occur early during sepsis, with activated coagulopathy and playing a major role in the pathophysiology of sepsis-induced acute kidney injury (AKI). (biomedcentral.com)
  • As a consequence, the clinical approach to AKI requires consideration and treatment of underlying causes of AKI such as unrecognized sepsis together with haemodynamic resuscitation aimed at preserving tissue perfusion, an enhanced level of monitoring for further deterioration and avoidance of secondary organ injury by minimization of nephrotoxin exposure and avoidance of other complications. (springer.com)
  • Heavy blood loss, an injury, or a bad infection called sepsis can reduce blood flow to the kidneys. (rexhealth.com)
  • Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. (jci.org)
  • Clinicians increasingly recognize acute kidney injury as an in-hospital complication of sepsis, heart conditions, and surgery. (cdc.gov)
  • Pre-renal kidney injury is caused by hypoperfusion of the kidneys most commonly caused by volume depletion (burns, hemorrhage, GI losses), hypotension (sepsis, shock), and renal artery stenosis (ADIS International Ltd., 2009, Cheung et al. (thefreelibrary.com)
  • Astute Medical's current areas of interest include abdominal pain, acute coronary syndromes, cerebrovascular injury, kidney injury and sepsis. (prnewswire.co.uk)
Loss of kidney6
  • Pediatric acute kidney injury refers to the sudden loss of kidney function due to an underlying illness. (childrens.com)
  • In this topic review, the acute loss of kidney function will be referred to as AKI. (uptodate.com)
  • Acute kidney injury (AKI) is the sudden loss of kidney function. (denverhealth.org)
  • Acute Kidney Injury (AKI) describes the sudden and often temporary loss of kidney function that can occur when the kidney is damaged. (ul.ie)
  • A buildup of these waste products in the blood points to a loss of kidney function. (lmh.org)
  • It can range from minor loss of kidney function to complete kidney failure (1). (webwire.com)
Urine16
  • Clinical assessment for acute kidney injury involves doing a blood test to check serum creatinine levels against a previous result, measuring urine volume and reviewing medication. (nice.org.uk)
  • A sudden blockage that stops urine from flowing out of the kidneys. (rexhealth.com)
  • Blood and urine tests can check how well your kidneys are working. (rexhealth.com)
  • ABSTRACT: Acute kidney injury is characterized by a rapid loss in kidney function with or without changes in urine output. (uspharmacist.com)
  • The Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) classification system divides acute kidney injury into three stages based upon the change in serum creatinine level, the change in urine output, or the need for renal replacement therapy ( TABLE 1 ). (uspharmacist.com)
  • The urine output criterion of 0.5 ml/kg/hour for 6 hours for acute kidney injury (AKI) has not been prospectively validated. (springer.com)
  • A rapid reduction of urine output may be the earliest indication of decreased kidney function. (springer.com)
  • Blockages to the flow of urine - urine is made in the kidneys and has to pass down long thin tubes to the bladder, and then the bladder releases the urine from time to time. (kidney.org.uk)
  • The first test is that urine will be tested for infection and to see if blood and protein is leaking from the kidneys. (kidney.org.uk)
  • Fanconi syndrome is an acute type of kidney failure caused by leakage out of the blood into the urine of substances that should normally be reabsorbed: phosphates (which help build bone), amino acids and bicarbonate, which raises the acidity of the blood (acidosis) to dangerous levels. (aidsmap.com)
  • The diagnosis of acute kidney injury is based on serum creatinine levels, urine output, and the need for renal replacement therapy. (aafp.org)
  • Causes of AKI are classified as either prerenal (due to decreased blood flow to the kidney), intrinsic renal (due to damage to the kidney itself), or postrenal (due to blockage of urine flow). (wikipedia.org)
  • A diagnosis is made when there is a rapid reduction in kidney function, as measured by serum creatinine, or based on a rapid reduction in urine output, termed oliguria (less than 400 mLs of urine per 24 hours). (wikipedia.org)
  • AKI is a disease that has afflicted humans from time immemorial, but early description of a clearer clinical picture for acute renal failure (ARF) was dated back to the year 1802 by William Heberden under the term 'ischuria renalis' suppression of urine flow. (omicsonline.org)
  • Creatinine is a chemical waste molecule transported through the bloodstream to the kidneys, which filter most of the waste and deposit it in the urine. (cincinnatichildrens.org)
  • Think of the kidneys as your body's filtration system: As blood passes through them, the kidneys sift out waste products and excess fluid, which are removed from the body and come out in the urine. (healthcommunities.com)
Clinical24
  • Commissioners (clinical commissioning groups) ensure that they commission services in which people who present with an illness with no clear acute component and 1 or more indications or risk factors for acute kidney injury are assessed for acute kidney injury. (nice.org.uk)
  • This figure represents a partial list and points to ischemia as being a common pathway in a variety of clinical states affecting the kidney. (jci.org)
  • For this report, acute kidney injury hospitalizations were defined in two ways using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). All acute kidney injury was defined as the occurrence of at least one diagnostic code 584 (acute renal failure) or the occurrence of at least one procedure code of 39.95 (hemodialysis) or 54.98 (peritoneal dialysis). (cdc.gov)
  • Urinary biomarkers, however, require only a half hour or so to obtain a measure of the severity of kidney damage, explains Thomas Nickolas, MD, MS, assistant professor of clinical medicine at Columbia University College of Physicians and Surgeons and a kidney specialist at NewYork-Presbyterian Hospital/The Allen Hospital. (eurekalert.org)
  • This term also highlights that injury to the kidney that does not result in 'failure' is also of great clinical significance. (uptodate.com)
  • We also discuss the pathophysiology of acute kidney injury (AKI) and the clinical symptoms preceding HPS. (scirp.org)
  • First, they looked at suPAR levels and the risk of acute kidney injury in three clinical settings. (rush.edu)
  • Tom is also the GP Clinical-Academic Lead for the NIHR CLAHRC Greater Manchester Kidney Health Programme. (rcgp.org.uk)
  • Kellum, who also is associate director for acute illness at Pitt's Institute for Precision Medicine, plans to make improvements to the clinical decision support application in the future. (eurekalert.org)
  • 2012) Acute Kidney Injury in Pregnancy: A Clinical Challenge. (scirp.org)
  • 2014) Clinical Profile and Outcome of Acute Kidney Injury Related to Pregnancy in Developing Countries: A Single-Center Study from India. (scirp.org)
  • A look at the following clinical trial: A Study to Evaluate the Safety and Efficacy of AC607 for the Treatment of Kidney Injury in Cardiac Surgery Subjects (ACT-AKI). (renalandurologynews.com)
  • A look at the following clinical trial: Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass. (renalandurologynews.com)
  • A look at the following clinical trial: Modalities of Renal Replacement Therapy in Pediatric Acute Kidney Injury (EPURE). (renalandurologynews.com)
  • A look at the following clinical trial: Levosimendan in Acute Kidney Injury Study (LAKIS). (renalandurologynews.com)
  • A look at the following clinical trial: Plasma Cystatin C and Acute Kidney Injury. (renalandurologynews.com)
  • A look at the following clinical trial: PRevention of Acute Kidney Injury Initiated With Electronic Surveillance Enhancement (PRAISE). (renalandurologynews.com)
  • A look at the following clinical trial: Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension. (renalandurologynews.com)
  • These should serve only as one piece of data to inform clinical decision making, as many electrolyte concentrations can be affected by dietary and other non-kidney function-related factors. (clinicaladvisor.com)
  • Acute kidney injury is diagnosed on the basis of clinical history and laboratory data. (wikipedia.org)
  • Acute kidney injury (AKI) previously known as acute renal failure is a common clinical syndrome, with multiple etiologies and a complex array of clinical and biochemical changes. (omicsonline.org)
  • Moreover it has been reported that early and small change in kidney function has a significant clinical impact and associated with unfavorable outcome, although affected cases are indiscriminately classified under ARF [ 7 ]. (omicsonline.org)
  • Mike Durkin, national director for patient safety, said: "Acute kidney injury contributes to around 40,000 deaths every year in England, around 13,000 of which are preventable, and yet this cause of harm is not known by the public [and] not always recognised by clinical staff. (hsj.co.uk)
  • A major challenge in the treatment of AKI is that the clinical criteria for recognition are markers of established kidney damage or impaired function. (businesswire.com)
Pediatric Acute Kidney3
  • What is a Pediatric Acute Kidney Injury? (childrens.com)
  • What are the signs and symptoms of a Pediatric Acute Kidney Injury? (childrens.com)
  • What are the causes of a Pediatric Acute Kidney Injury? (childrens.com)
Mortality7
  • Acute kidney injury (AKI) is the most common cause of organ dysfunction in critically ill adults, with a single episode of AKI, regardless of stage, carrying a significant morbidity and mortality risk. (biomedcentral.com)
  • Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity. (hindawi.com)
  • 6 Since acute kidney injury is associated with a high incidence of complications and mortality rates can range from 25% and 80%, it is vital that the condition be detected early and managed appropriately. (uspharmacist.com)
  • COVID-19 associated acute kidney injury (AKI) has been reported in different countries1 2 and I agree that early detection and diagnosis with AKI in COVID-19 is essential for effective healthcare management in terms of the high risk for mortality of this comorbidity. (bmj.com)
  • PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Acute kidney injury (AKI) affects more than 10 million people worldwide per year with 15-60% mortality. (sbir.gov)
  • It is estimated that about 2 million people die of AKI every year and mortality increases as kidney function declines [ 3 ]. (omicsonline.org)
  • IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. (wikipedia.org)
Diagnosis6
  • It is important for healthcare professionals to be aware of when it is necessary to assess the risk of acute kidney injury so that a diagnosis is not missed. (nice.org.uk)
  • All people presenting with no obvious acute illness who have indications or risk factors for acute kidney injury should be assessed for a possible diagnosis. (nice.org.uk)
  • Recently urinary biomarkers like interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) have been used for the early diagnosis of AKI [ 3 ]. (hindawi.com)
  • However, methods for early diagnosis of AKI are still lacking and consequently this is one of the research topics solicited by the National Institute of Diabetes and Digestive and Kidney Diseases. (sbir.gov)
  • So far, several new AKI biomarkers have been discovered and validated to improve early diagnosis, degree of severity, pathophysiology, differential diagnosis, prediction for major kidney adverse events (MAKE, risk groups for progressive renal failure, need for renal replacement therapy [RRT], or death). (medworm.com)
  • The Company's focus is community- and hospital-acquired acute conditions that require rapid diagnosis and risk assessment. (prnewswire.co.uk)
Damage to the kidneys2
  • Acute kidney injury is sudden damage to the kidneys, which can sometimes result in kidney failure. (nice.org.uk)
  • AKI is sudden damage to the kidneys that causes them to not work properly. (webwire.com)
Treat acute2
  • Dr. Parikh echoes the same caution, saying, "These findings are very early, but the results suggest that we could one day have a non-invasive test for NAD+ status and perhaps even treat acute kidney injury by boosting NAD+ levels. (medicalnewstoday.com)
  • A patient safety alert has been issued by NHS Improvement to help NHS providers better recognise and treat acute kidney injury, which causes more than 13,000 preventable deaths a year. (hsj.co.uk)
Blood flow to the kidneys3
  • A sudden, serious drop in blood flow to the kidneys. (rexhealth.com)
  • For example, your doctor may need to restore blood flow to the kidneys, stop any medicines that may be causing the problem, or remove or bypass a blockage in the urinary tract. (rexhealth.com)
  • During surgery the blood flow to the kidneys may be reduced and this can lead to AKI. (kidney.org.uk)
Function40
  • Bywaters EG, Beall D. Crush injuries with impairment of renal function. (springer.com)
  • Acute kidney injury (AKI) is a commonly encountered syndrome associated with various aetiologies and pathophysiological processes leading to decreased kidney function. (nih.gov)
  • Acute kidney injury (AKI), formerly known as "acute renal failure," has been traditionally described as a rapid (ranging from hours to weeks, to less than 3 months) decrease in kidney function as measured by increases in serum creatinine. (jci.org)
  • Acute kidney injury is a sudden decrease in kidney function with or without kidney damage, occurring over a few hours or days. (cdc.gov)
  • Physicians typically measure a patient's creatinine levels to determine kidney function. (eurekalert.org)
  • Acute kidney injury, also known as acute renal failure , is a condition characterized by the rapid loss (within 48 hours) of the excretory function of the kidneys based upon an elevation in serum creatinine and urea concentrations (both of which are end products of nitrogen metabolism). (uspharmacist.com)
  • Prerenal causes of acute kidney injury are processes in which the underlying kidney function may be normal, but the effective arteriolar blood volume is reduced, depriving the kidneys of blood flow. (uspharmacist.com)
  • Because kidney function usually returns to baseline if AKI is identified early and appropriately treated, all nurses need to be alert for risk factors for AKI, able to recognize the early signs and symptoms, and prepared to implement appropriate nursing interventions and administer treatment prescribed by the healthcare provider. (nursingcenter.com)
  • The term AKI replaces the earlier term acute renal failure (ARF) to better reflect the spectrum of injury ranging from minor changes in renal function markers to the need for renal replacement therapy (RRT) that may arise from multiple factors. (nursingcenter.com)
  • These insults cause acute kidney injury (AKI) characterized by decreased kidney function. (pnas.org)
  • After repair, kidney function may not return back to baseline due to residual subclinical inflammation and fibrosis. (pnas.org)
  • While kidney function is monitored using simple blood tests, subtle changes can elude or delay detection of a problem. (eurekalert.org)
  • The program monitored levels of blood creatinine, a standard measure of kidney function, over time and analyzed changes in those levels. (eurekalert.org)
  • It also helped determine the stage of injury based on changes from the patient's baseline kidney function. (eurekalert.org)
  • With an acute kidney injury, kidney function deteriorates in a few hours or days. (eurekalert.org)
  • Acute Kidney Injury (AKI) is a sudden and recent reduction in the level of kidney function. (kidney.org.uk)
  • If the level of this waste has doubled it means that the kidney function has halved and that there is AKI. (kidney.org.uk)
  • Due to the limitations of serum creatinine, there is intense interest in identifying and developing novel biomarkers that more accurately and quickly detect acute kidney injury and kidney function in general," said Thomas Nickolas, MD MS, lead author of the paper. (aacc.org)
  • They will use the samples to do tests in the laboratory (different to routine tests) that may help them to compare renal function and biomarkers of renal injury. (clinicaltrials.gov)
  • Some blood pressure medications are known risk factors for acute kidney injury (AKI) - a sudden deterioration in kidney function. (bloodpressureuk.org)
  • Advancements in acute dialysis technology and a recognition that even small reductions in kidney function may portend worse prognosis have led to more aggressive and earlier intervention in children with acute kidney injury. (clinicaladvisor.com)
  • have shown that MG53 performs a similar function in the kidney as well. (sciencemag.org)
  • The various symptoms of acute kidney injury result from the various disturbances of kidney function that are associated with the disease. (wikipedia.org)
  • Both kidneys need to be affected as one kidney is still more than adequate for normal kidney function. (wikipedia.org)
  • AKI is a comprehensive term reflecting the full spectrum of kidney injury-from mild alterations in kidney function through end-stage kidney disease that requires renal replacement therapy- thereby more adequately replacing the former term acute renal failure . (uspharmacist.com)
  • It is until 2004, when the Acute Dialysis Quality Initiative (ADQI) group proposed RIFLE (risk, injury, and failure, loss of function and end-stage renal failure) as consensus criteria for AKI definition and staging. (omicsonline.org)
  • In 1941 Bywaters and Beall during World War II reported detailed description of impaired renal function associated with war crush injury. (omicsonline.org)
  • However, in 1951 Homer Smith in his textbook entitled The Kidney-Structure and Function in Health and Disease was the one who introduced the term ARF. (omicsonline.org)
  • it is associated with high death rates and characterised by the rapid loss of the kidney function. (cochrane.org)
  • The aim of this review was to investigate the effect of different timing of RRT initiation (early or standard) on death, recovery of kidney function, and adverse events in people with AKI who are critically ill. (cochrane.org)
  • Traditional markers--blood urea nitrogen (BUN) and serum creatinine (SCr) remain the gold standard for the assessment of kidney function. (oncologynurseadvisor.com)
  • Kidney failure occurs when the kidneys lose their ability to function. (lmh.org)
  • Symptoms of decreased kidney function, such as fluid buildup or electrolyte imbalance , are more likely to develop with acute kidney injury, regardless of how long the kidney has been malfunctioning. (lmh.org)
  • Survivors of acute renal failure who do not recover renal function. (bmj.com)
  • The DyeVert portfolio allows healthcare providers to monitor cumulative dye dose specific to each patient s kidney function determined prior to the procedure. (webwire.com)
  • Everyone experiences a decline in kidney function with age, some more than others. (healthcommunities.com)
  • Also, many people don't initially realize they have kidney disease the kidneys are remarkably resilient, and it's possible for them to function normally at about half capacity with few or no symptoms. (healthcommunities.com)
  • Regular follow-up with your doctor, who can monitor your kidney function, is very important. (healthcommunities.com)
  • Acute kidney injury (AKI) is a potentially lethal condition for which no therapy is available beyond replacement of renal function. (biologists.org)
  • Systemic crotonate administration protected from experimental AKI, preventing the decrease in renal function and in kidney PGC-1α and sirtuin-3 levels as well as the increase in CCL2 expression. (biologists.org)
Incidence of acute6
  • Incidence of acute kidney injury. (nice.org.uk)
  • 4 Furthermore, the incidence of acute kidney injury is increasing in community and hospital settings. (uspharmacist.com)
  • Researchers analyzed national data for the years 2000 to 2009 and found that the incidence of acute kidney injury requiring dialysis rose about 10 percent on average a year. (medicinenet.com)
  • The incidence of acute kidney injury has increased in recent years, both in the community and in hospital settings. (aafp.org)
  • 1 , 2 The estimated incidence of acute kidney injury is two to three cases per 1,000 persons. (aafp.org)
  • Over the past decade, the incidence of acute kidney injury (AKI) in older adults has increased. (uspharmacist.com)
Failure29
  • Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. (springer.com)
  • It's a sudden onset of kidney failure that can happen within a few hours or days. (childrens.com)
  • It does not cover care for adults with kidney failure provided by renal replacement therapy services, which is included in NICE's quality standard for replacement therapy services . (nice.org.uk)
  • You have a long-term health problem such as kidney or liver disease, diabetes, high blood pressure, heart failure, or obesity. (rexhealth.com)
  • Mehta R, Kellum JA, Levin A. From acute renal failure to acute kidney injury: what's changed? (medscape.com)
  • The incidence of dialysis-requiring acute kidney injury is now greater than the incidence of kidney failure requiring dialysis or transplant, the researchers said. (medicinenet.com)
  • and (2) 250 participants with AKI requiring renal replacement therapy (RRT) who had not yet initiated RRT enrolled in the Acute Renal Failure Trial Network (ATN) Study. (nih.gov)
  • In this study, we found evidence that a specific protein produced by immune cells in the bone marrow, called soluble urokinase plasminogen activator receptor (suPAR,) is a strong risk factor for acute forms of kidney failure, that occur as consequence of general medical procedures," said Jochen Reiser, MD, PhD , a professor at Rush University Medical Center and chairperson of Rush's Department of Internal Medicine . (rush.edu)
  • AKI used to be called acute kidney failure, which is misleading because often the kidneys don't failure completely, and usually get better. (kidney.org.uk)
  • 2008) Pregnancy-Related Acute Renal failure: A Single-Center Experience. (scirp.org)
  • Krane, N.K. (1988) Acute Renal Failure in Pregnancy. (scirp.org)
  • Septic AKI was also associated with greater severity of AKI (RIFLE category injury or failure) compared with nonseptic AKI. (unboundmedicine.com)
  • Many substances that are not toxic to the kidneys in a healthy person may become toxic in a person who has existing kidney problems or another condition that increases his or her risk of acute kidney injury, such as heart failure, diabetes, or multiple myeloma. (wellspan.org)
  • ACE-I and ARBs are life-saving medications which not only reduce blood pressure, but also reduce the progression of kidney disease, heart failure and diabetes. (bloodpressureuk.org)
  • Multidimensional pediatric AKI definitions include the pediatric modified RIFLE criteria (pRIFLE = Risk, Injury, Failure, Loss, End-Stage kidney disease) and the Acute Kidney Injury Newtork (AKIN criteria). (clinicaladvisor.com)
  • Notable causes of prerenal AKI include low blood volume (e.g., dehydration), low blood pressure, heart failure (leading to cardiorenal syndrome), hepatorenal syndrome in the context of liver cirrhosis, and local changes to the blood vessels supplying the kidney. (wikipedia.org)
  • This section covers general management of acute renal failure only. (edren.org)
  • Boston, MA -- ( SBWIRE ) -- 12/21/2012 -- Global Markets Direct's, 'Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Review, H2 2012', provides an overview of the indication's therapeutic pipeline. (sbwire.com)
  • This report provides information on the therapeutic development for Acute Renal Failure (ARF) (Acute Kidney Injury), complete with latest updates, and special features on late-stage and discontinued projects. (sbwire.com)
  • It also reviews key players involved in the therapeutic development for Acute Renal Failure (ARF) (Acute Kidney Injury). (sbwire.com)
  • Acute Renal Failure (ARF) (Acute Kidney Injury) - Pipeline Review, Half Year is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. (sbwire.com)
  • A snapshot of the global therapeutic scenario for Acute Renal Failure (ARF) (Acute Kidney Injury). (sbwire.com)
  • A review of the Acute Renal Failure (ARF) (Acute Kidney Injury) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources. (sbwire.com)
  • Coverage of the Acute Renal Failure (ARF) (Acute Kidney Injury) pipeline on the basis of route of administration and molecule type. (sbwire.com)
  • Identify and understand important and diverse types of therapeutics under development for Acute Renal Failure (ARF) (Acute Kidney Injury). (sbwire.com)
  • Devise corrective measures for pipeline projects by understanding Acute Renal Failure (ARF) (Acute Kidney Injury) pipeline depth and focus of Indication therapeutics. (sbwire.com)
  • For this reason the Acute Dialysis Quality Initiative (ADQI) composed of intensivists and nephrologists developed a criteria for AKI: RIFLE (Risk, Injury, Failure, Loss and ESRD). (oncologynurseadvisor.com)
  • Spectrum of acute renal failure in the intensive care unit: the PICARD experience. (bmj.com)
  • About 30 percent of all AKI cases requiring dialysis are a result of increasing use of cardiac catheterization and ventilators, and the rise of hospital-acquired infections and acute heart failure. (healthcommunities.com)
Cases of acute kidney3
  • This is a retrospective observational study involving cases of acute kidney injury during pregnancy and hospitalized in our department from 1995 to 2015. (scirp.org)
  • They estimate that one in seven cases of acute kidney injury could be due to increased prescriptions for these drugs. (bloodpressureuk.org)
  • Most cases of acute kidney injury occur in people who are already in the hospital for other reasons. (lmh.org)
Symptoms9
  • People with acute kidney injury may present with no obvious signs or symptoms of this condition in primary or secondary care settings. (nice.org.uk)
  • symptoms or signs of a multi‑system disease affecting the kidneys and other organ systems (for example, signs or symptoms of acute kidney injury plus a purpuric rash). (nice.org.uk)
  • Symptoms suggesting acute kidney injury should not be dismissed based on a person's age - for example, ignoring urological symptoms in older people. (nice.org.uk)
  • Young age, neurological or cognitive impairment or disability may mean that people are less able to describe their symptoms, so it is important that healthcare professionals look out for changes in behaviour that suggest acute kidney injury in these groups. (nice.org.uk)
  • And for people who are already quite ill, the problem that's causing the kidney injury may be causing other symptoms. (rexhealth.com)
  • If you're not in the hospital but have symptoms of kidney injury, your doctor will ask about your symptoms, what medicines you take, and what tests you have had. (rexhealth.com)
  • Your symptoms can help point to the cause of your kidney problem. (rexhealth.com)
  • The mice soon started to display symptoms of acute kidney injury, including reduced NAD+ levels and higher levels of quinolinate. (medicalnewstoday.com)
  • Symptoms may reflect the actual cause of the kidney problem. (lmh.org)
Biomarkers8
  • Biomarkers can detect kidney stress and damage. (medscape.com)
  • The FDA-approved biomarkers TIMP2*IGFBP7 indicate kidney stress in advance of AKI. (medscape.com)
  • The combination of two urinary biomarkers, Tissue Inhibitor of Metalloproteinase 2 (TIMP-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7), has been shown to increase within 12 hours following renal insult, allowing assessment of risk for developing acute kidney injury. (clinicaltrials.gov)
  • A long journey for acute kidney injury biomarkers. (medworm.com)
  • These biomarkers can be classified into functional, damage and pre-injury phase biomarkers. (medworm.com)
  • Incorporating protein biomarkers and even genomics into the system could one day revolutionize patient care, not just for acute kidney injury, but for other illnesses. (eurekalert.org)
  • As a result, researchers have focused their attention on several promising urinary biomarkers more directly related to kidney injury. (aacc.org)
  • More recently urinary and serum biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18(IL-18) and kidney injury molecule 1 (KIM-1), Liver fatty acid binding protein (LFABP) and others have been shown to be more sensitive than SCr in detecting early kidney injury. (oncologynurseadvisor.com)
Organs6
  • The kidneys are highly complex organs with numerous functions and regulatory processes. (nursingcenter.com)
  • I have examined many COVID-19 injured organs including lung, kidney, liver and heart for tissue density of these receptors and found that kidney has the highest density of these receptors among the examined organs. (bmj.com)
  • The cells are made available to carry out subtle metabolic and endocrine functions that the patient's failing kidneys can no longer perform, thereby staunching a cascading decline in the patient's health and allowing time for the patient's own organs to recover,' Dr. Humes explains. (medgadget.com)
  • Atheroembolic disease results from showering of atheromatous debris into the microcirculation of the kidney and other organs. (renalandurologynews.com)
  • The kidneys are a pair of bean-shaped, fist-sized organs located in the lower back, on either side of the spine. (healthcommunities.com)
  • Organs involved in filtration (e.g., the kidneys and the liver), may be overwhelmed by the high load of cellular break down products, and face injury themselves (e.g., acute kidney injury). (wikipedia.org)
Ischemic acute1
  • They found that ischemic acute kidney injury induces HIF-1, which upregulates microRNA-668, which suppresses MTP18 and the result is kidney cell protection. (eurekalert.org)
Reperfusion Injury3
  • Indeed, several experimental studies from our laboratory have shown that mineralocorticoid receptor blockade protects the kidney against ischemia/reperfusion injury. (clinicaltrials.gov)
  • citation needed] While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury, to date, none have explored the role of stem cells in muscle tissue exposed to ischemia-reperfusion injury. (wikipedia.org)
  • The ischemia-reperfusion injury associated with surgical tourniquets is typically not clinically apparent when used for less than two hours. (wikipedia.org)
Prerenal5
  • The causes of acute kidney injury may be divided into three classes: prerenal, intrinsic, and postrenal ( TABLE 2 ). (uspharmacist.com)
  • Prerenal factors are the leading cause of acute kidney injury in the community, comprising about 70% of cases. (uspharmacist.com)
  • The diagnostic evaluation can be used to classify acute kidney injury as prerenal, intrinsic renal, or postrenal. (aafp.org)
  • The causes of acute kidney injury are commonly categorized into prerenal, intrinsic, and postrenal. (wikipedia.org)
  • Prerenal causes of AKI ("pre-renal azotemia") are those that decrease effective blood flow to the kidney and cause a decrease in the glomerular filtration rate (GFR). (wikipedia.org)
Prevention2
  • Through the Think Kidneys Programme , national levers have been introduced to improve the prevention, detection and management of AKI. (rcgp.org.uk)
  • Dopamine use is not recommended for the prevention of acute kidney injury. (aafp.org)
Interstitial2
  • Acute interstitial nephritis (AIN) is inflammation of the kidneys. (wellspan.org)
  • Physical examination may also provide other clues as to the underlying cause of the kidney problem, such as a rash in interstitial nephritis (or vasculitis) and a palpable bladder in obstructive nephropathy. (wikipedia.org)
Transplant7
  • It does not cover managing acute kidney injury in pregnant women or in people with a kidney transplant. (nice.org.uk)
  • Heart or belly surgery or a bone marrow transplant can make you more likely to have kidney problems. (rexhealth.com)
  • A small number of them will need to have regular dialysis or a kidney transplant . (rexhealth.com)
  • 5:40 How could using deceased donor acute kidney injury kidneys for transplant change the way we practice medicine? (hopkinsmedicine.org)
  • 7:40 What's next in research for deceased kidney transplant donors with AKI? (hopkinsmedicine.org)
  • In our End Stage Renal Disease Program -which includes the dialysis unit and our Kidney Transplant Program -our treatment is influenced by our research. (childrenshospital.org)
  • We currently participate in more NIH-sponsored pediatric kidney transplant research studies than any other program in the nation. (childrenshospital.org)
Complications4
  • Acute kidney injury (AKI) is common and is associated with serious short- and long-term complications. (biomedcentral.com)
  • In acute kidney injury , the kidneys suddenly stop functioning - usually as a result of complications during hospitalization. (medicalnewstoday.com)
  • The pregnancy care and quality of access to care remain fundamental to prevent complications of pregnancy, including acute kidney injury. (scirp.org)
  • These complications often do not develop until kidney disease has been present for some time. (lmh.org)
Serum4
  • This results in an elevation of serum blood urea nitrogen (BUN), creatinine, and other metabolic waste products that are normally excreted by the kidney. (uptodate.com)
  • Interestingly, the aging kidney had decreased serum creatinine compared to young controls 1 day following mercuric chloride injury, but by day 4, serum creatinine was significantly elevated, suggesting that the aging kidney did not recover from injury. (mdpi.com)
  • This conclusion is supported by the findings that serum creatinine and kidney injury molecule-1 ( Kim-1 ) gene expression remain elevated compared to young controls at 10 days post-injury. (mdpi.com)
  • citation needed] Serum creatinine and BUN may be elevated in the setting of acute kidney injury. (wikipedia.org)
Dehydration6
  • Not enough fluid in the body (dehydration) also can harm the kidneys. (rexhealth.com)
  • It can result from a literal blow to the kidney, in a fall or car accident, or from dehydration in an overzealous student athlete. (eurekalert.org)
  • Surgery - an operation can 'stress' the kidneys and cause AKI, especially if there is infection and/or dehydration. (kidney.org.uk)
  • If the kidney injury is the result of dehydration, there may be thirst as well as evidence of fluid depletion on physical examination. (wikipedia.org)
  • Acute kidney injury (AKI) is usually caused by an event that leads to kidney malfunction, such as dehydration , blood loss from major surgery or injury, or the use of medicines . (lmh.org)
  • Blood clots, dehydration and urinary-tract blockages can place the kidneys in immediate peril, too. (healthcommunities.com)
Pathophysiology3
  • Acute kidney injury: an overview of pathophysiology and treatments. (thefreelibrary.com)
  • S.v. Acute kidney injury: an overview of pathophysiology and treatments. (thefreelibrary.com)
  • To provide an overview of acute kidney injury, its pathophysiology, and treatments. (thefreelibrary.com)
RIFLE3
  • Acute kidney injury in the intensive care unit according to RIFLE. (springer.com)
  • Acute kidney injury in the paediatric intensive care unit: identification by modified RIFLE criteria. (medscape.com)
  • A modification of the RIFLE criteria was proposed by the Acute Kidney Injury Network (AKIN). (oncologynurseadvisor.com)
Intrinsic acute kidney2
  • The treatment of intrinsic acute kidney injury includes identifying and correcting the cause of the kidney injury. (wellspan.org)
  • ATN is a common cause of intrinsic acute kidney injury often seen in people who are already hospitalized. (wellspan.org)
Hypertension3
  • Improved awareness by health care providers that diabetes, hypertension, and advanced age are important risk factors for acute kidney injury might reduce its occurrence and improve management of the underlying diseases in an aging population. (cdc.gov)
  • Diabetes, hypertension, and advanced age are primary risk factors for acute kidney injury. (cdc.gov)
  • Improving both patient and provider awareness that diabetes, hypertension, and advancing age are frequently associated with acute kidney injury might reduce its occurrence and improve management of the underlying diseases in an aging population. (cdc.gov)
Illness10
  • People who present with an illness with no clear acute component and 1 or more indications or risk factors for acute kidney injury are assessed for this condition. (nice.org.uk)
  • Evidence of local arrangements to ensure that people who present with an illness with no clear acute component and 1 or more indications or risk factors for acute kidney injury are assessed for acute kidney injury. (nice.org.uk)
  • Proportion of presentations of illness with no clear acute component along with 1 or more indications or risk factors for acute kidney injury where an assessment for acute kidney injury is done. (nice.org.uk)
  • People who are generally unwell with no obvious recent or sudden illness and who have indications or risk factors for acute kidney injury are assessed to see whether they have this condition. (nice.org.uk)
  • A person with an illness with no clear acute component feels generally unwell (for example, tired with perhaps nausea or swelling of the legs), and has no clear idea of when the illness began, and no clear sudden acute illness. (nice.org.uk)
  • The term 'acute' means an illness that has developed recently. (kidney.org.uk)
  • Injury means that the kidney is damaged, usuall6y by another illness or sometimes by medication. (kidney.org.uk)
  • Acute kidney injury (AKI) is becoming more prevalent in hospitalized children, and now more often results from another organ/system illness or its treatment. (clinicaladvisor.com)
  • The epidemiology of pediatric AKI has changed from the 1990s from primary kidney disease to another system illness or its treatment. (clinicaladvisor.com)
  • Acute kidney injury (AKI) is also a strong risk factor for hypoglycemia during critical illness ( 7 ). (diabetesjournals.org)
Diabetes12
  • Diabetes is a known risk factor for acute kidney injury. (cdc.gov)
  • The increasing number of persons living with diabetes is likely to also increase the number of persons with acute kidney injury. (cdc.gov)
  • Although a number of U.S. studies have indicated an increasing incidence of dialysis-treated acute kidney injury since the late 1990s ( 3 ), no data are available on national trends in diabetes-related acute kidney injury. (cdc.gov)
  • To estimate diabetes- and nondiabetes-related acute kidney injury trends, CDC analyzed 2000-2014 data from the National Inpatient Sample (NIS) ( 4 ) and the National Health Interview Survey (NHIS) ( 5 ). (cdc.gov)
  • Age-standardized rates of acute kidney injury hospitalizations increased by 139% (from 23.1 to 55.3 per 1,000 persons) among adults with diagnosed diabetes, and by 230% (from 3.5 to 11.7 per 1,000 persons) among those without diabetes. (cdc.gov)
  • The landscape of kidney disease in diabetes has shifted. (diabetesjournals.org)
  • The classical dogma of "diabetic nephropathy" progressing through stages of albuminuria, leading to decline in glomerular filtration rate and end-stage kidney disease (ESKD), has been replaced by a more nuanced understanding of the complex and heterogeneous nature of kidney disease in diabetes. (diabetesjournals.org)
  • Paralleling this evolution, standardized definitions have resulted in a growing appreciation that acute kidney injury (AKI) is increasing in its incidence rapidly and that people with diabetes are much more likely to develop AKI than people without diabetes. (diabetesjournals.org)
  • Recognizing AKI as a bona fide complication of diabetes should open up new avenues for investigation that may ultimately improve the outlook for people living with diabetes and at risk for kidney disease. (diabetesjournals.org)
  • The study was cosponsored by the Department of Veterans Affairs and NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (nih.gov)
  • Importantly, Fanconi syndrome was not associated with any predisposing factor for kidney dysfunction: age, sex, high blood pressure or lipids, diabetes, viral hepatitis, low CD4 count or lowest-ever count, of baseline low eGFR. (aidsmap.com)
  • There has been an increase in the prevalence of acute kidney injury (AKI) over the past 15 years due to the increased percentage of older adults in the population and increased survival rates with cardiac disease and diabetes mellitus (Talbot, 2008). (thefreelibrary.com)
Contrast-associated acute kidney1
Hospitalization with acute1
  • Time to first hospitalization with acute kidney injury or receipt of acute dialysis served as the primary endpoint. (healio.com)
Creatinine5
  • Schetz M, Gunst J, Van den Berghe G. The impact of using estimated GFR versus creatinine clearance on the evaluation of recovery from acute kidney injury in the ICU. (springer.com)
  • But creatinine levels can remain normal for several hours after acute kidney damage, and an accurate assessment requires measurements taken over a period of 1-3 days. (eurekalert.org)
  • Preoperative creatinine greater than 1.2 mg/dL, combined valve and bypass procedures, emergency surgery, and preoperative intra-aortic balloon pump are risk factors most strongly correlated with post-cardiopulmonary bypass acute kidney injury. (wikipedia.org)
  • Drugs such as cimetidine and trimethoprim may result in a rise in SCr without any evidence of kidney injury, since they use same transport mechanism as creatinine for secretion in the proximal renal tubule. (oncologynurseadvisor.com)
  • In these people, acute kidney injury is usually diagnosed when routine tests show a sudden increase in creatinine and blood urea nitrogen (BUN) levels. (lmh.org)
Fluid4
  • Kidneys maintain fluid and electrolyte balance, excrete waste products, and regulate blood pressure. (pnas.org)
  • Hemodialysis uses a machine to clean waste and extra fluid from the blood when the kidneys can't do the job. (nih.gov)
  • Kidneys clean waste products from the blood and maintain fluid levels in the body. (denverhealth.org)
  • Management of acute kidney injury involves fluid resuscitation, avoidance of nephrotoxic medications and contrast media exposure, and correction of electrolyte imbalances. (aafp.org)
Complication3
  • Acute kidney injury is a rare but serious complication of pregnancy. (scirp.org)
  • Acute Kidney Injury is a frequent complication in this population and negatively impacts the survival. (clinicaltrials.gov)
  • Bleeding is a common complication of warfarin anticoagulation and not uncommonly affects the kidney and urinary tract. (omicsonline.org)
Inflammation1
  • Pain in the flanks may be encountered in some conditions (such as clotting of the kidneys' blood vessels or inflammation of the kidney). (wikipedia.org)
Myocardial infarction1
  • If you compare what I could call a 'kidney attack' or (Acute Kidney Injury) requiring dialysis to a heart attack or a myocardial infarction the care is very different," Vassalotti said. (reuters.com)
20163
  • In 2016, 4.4% of Medicare fee-for-service beneficiaries experienced a hospitalization complicated by Acute Kidney Injury (AKI), double the proportion of 2.2% in 2006 (Figure 5.1). (usrds.org)
  • Al-Saqladi AWM (2016) Acute Kidney Injury: New Definitions and Beyond. (omicsonline.org)
  • The study is being published in conjunction with presentation of the data at Kidney Week 2016, the American Society of Nephrology's annual meeting, in Chicago. (cincinnatichildrens.org)
Update On Acute Kidney Injury In The Intensive Care Unit | Audio Digest
Update On Acute Kidney Injury In The Intensive Care Unit | Audio Digest (audio-digest.org)
KIM-1 antibodies for acute kidney injury | Medix Biochemica
KIM-1 antibodies for acute kidney injury | Medix Biochemica (medixbiochemica.com)
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Article Metrics - Acute kidney injury from SGLT2 inhibitors: potential mechanisms | Nature Reviews Nephrology (nature.com)
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Novel Biomarkers of Kidney Function: Introduction and Overview, Characteristics of an Ideal Marker for Kidney Disease,... (emedicine.medscape.com)
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Liver Failure - Types, Causes, Symptoms, Complications, Diagnosis, Treatment & Prevention (medindia.net)
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Biomarkers identify acute kidney injury in emergency patients | EurekAlert! Science News (eurekalert.org)
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The BMJ research homepage: make an impact, change clinical practice | The BMJ (bmj.com)
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DailyMed - WARFARIN SODIUM tablet (dailymed.nlm.nih.gov)
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Metabolites | Free Full-Text | Microbiome-Metabolome Signature of Acute Kidney Injury (mdpi.com)
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Acute Kidney Injury in Critically Ill Patients - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
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Acute Kidney Injury | Boston Children's Hospital (childrenshospital.org)