Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Immunizing agent containing IMMUNOGLOBULIN G anti-Rho(D) used for preventing Rh immunization in Rh-negative individuals exposed to Rh-positive red blood cells.
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)
The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.
A verocytotoxin-producing serogroup belonging to the O subfamily of Escherichia coli which has been shown to cause severe food-borne disease. A strain from this serogroup, serotype H7, which produces SHIGA TOXINS, has been linked to human disease outbreaks resulting from contamination of foods by E. coli O157 from bovine origin.
Strains of ESCHERICHIA COLI that are a subgroup of SHIGA-TOXIGENIC ESCHERICHIA COLI. They cause non-bloody and bloody DIARRHEA; HEMOLYTIC UREMIC SYNDROME; and hemorrhagic COLITIS. An important member of this subgroup is ESCHERICHIA COLI O157-H7.
Infections with bacteria of the species ESCHERICHIA COLI.
Proteins obtained from ESCHERICHIA COLI.
A plant genus of the family FABACEAE.
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.
The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.
Proteins found in any species of protozoan.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
It occurs occasionally in acute conditions, namely blood loss and hemolysis. If the MCV was determined by automated equipment, ...
ISBN 0-19-262515-2. Shukla, Sandhya; Sitrin, Michael (2015-07-09). "Hemolysis in Acute Alcoholic Hepatitis: Zieve's Syndrome". ... Melrose, W. D.; Bell, P. A.; Jupe, D. M.; Baikie, M. J. (1990-01-01). "Alcohol-associated haemolysis in Zieve's syndrome: a ... Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged heavy alcohol use. It is ...
More often, however, Kidd antibodies cause acute extravascular hemolysis. They are a notorious cause of delayed hemolytic ... Acute Transplant Rejection Induced By Blood Transfusion Reaction to the Kidd Blood Group System. Nephrology Dialysis ... Kidd antibodies are dangerous as they are capable of causing severe acute hemolytic transfusion reactions. They are unique in ... Kidd antibodies are often capable of binding complement and causing intravascular hemolysis. ...
Acute severe hemolysis results, with multi-organ failure, including DIC and kidney failure. In addition there is a direct ... Oliver J.; MacDowell M., Tracy A (1951). "The Pathogenesis of Acute Renal Failure Associated with Traumatic and Toxic Injury. ... This leads to increased permeability of the membrane, and severe hemolysis. The denaturation of hemoglobin overwhelms the ...
Association of methylprednisolone and intravenous immunoglobulin can control hemolysis in acute severe cases. Sometimes ... there are two principal mechanisms of hemolysis; intravascular and extravascular. Intravascular hemolysis describes hemolysis ... Extravascular hemolysis refers to hemolysis taking place in the liver, spleen, bone marrow, and lymph nodes. In this case ... Chronic hemolysis leads to an increased excretion of bilirubin into the biliary tract, which in turn may lead to gallstones. ...
"Drug-induced hemolysis: Cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction". ... "Immune Hemolysis: Diagnosis and Treatment Recommendations". Seminars in Hematology. Anemia in Clinical Practice. 52 (4): 304- ... Quinidine Penicillin in high doses can induce immune mediated hemolysis via the hapten mechanism in which antibodies are ...
Rees; Kelsey, Richards (March 1993). "Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase ... Exercise-induced bronchoconstriction (EIB) indicates acute narrowing of the airways as a result of vigorous exercise. EIB seems ...
... may be not recommended in those with G6PD deficiency, as it may cause acute hemolysis. It is generally not ... Meloni G, Meloni T (January 1996). "Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM". Br. J. Haematol ...
Variable degrees of hemolysis and intermittent episodes of vascular occlusion resulting in tissue ischemia and acute and ... Cutaneous photosensitivity; acute neurovisceral crises Medical procedure[edit]. Genetic testing is often done as part of a ... Predisposition of acute myeloid leukemia; skeletal abnormalities; radial hypoplasia and vertebral defect and other physical ...
Haemolysis is reported. It has also been reported to cause post kidney failure in children. Like other antibiotics, ceftriaxone ... Li N, Zhou X, Yuan J, Chen G, Jiang H, Zhang W (April 2014). "Ceftriaxone and acute renal failure in children". Pediatrics. 133 ... Guleria VS, Sharma N, Amitabh S, Nair V (September-October 2013). "Ceftriaxone-induced hemolysis". Indian Journal of ... Medical uses include: lower respiratory tract infections acute bacterial otitis media skin and skin structure infections ...
Acute hemolytic transfusion reactions due to immune hemolysis may occur in patients who have no antibodies detectable by ... Hemolysis leads to elevated bilirubin levels. After delivery bilirubin is no longer cleared (via the placenta) from the ... Like other forms of severe neonatal jaundice, there is the possibility of the neonate developing acute or chronic kernicterus, ... "Acute hemolytic transfusion reactions may be either immune-mediated or nonimmune-mediated. Immune-mediated hemolytic ...
Association of methylprednisolone and intravenous immunoglobulin can control hemolysis in acute severe cases. ... Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood ... Chronic hemolysis leads to an increased excretion of bilirubin into the biliary tract, which in turn may lead to gallstones. ... Certain aspects of the medical history can suggest a cause for hemolysis, such as drugs, consumption of fava beans due to ...
It can present as an acute non-recurrent postinfectious event in children, or chronic relapsing episodes in adults with ... For intravascular hemolysis, the laboratory parameters include increased serum free hemoglobin, lactate dehydrogenase, ... Reticulocytosis may not be apparent in the acute phase or when there is viral-induced myelosuppression. Once the clinical ... Intensive care for the development of acute kidney injury should be offered. Plasmapheresis is proposed to be an adjunctive ...
Symptoms of favism include hemolysis, prolonged jaundice, kernicterus, and even acute renal failure in extreme cases. Divicine ...
The symptoms of acute tomatine poisoning in animals are similar to the symptoms of poisoning by solanine, a potato ... Direct injection of tomatine into mice also causes an increase in blood pressure due to hemolysis, and calcium release from ... There is no evidence that consumption of tomatoes causes acute toxic or genotoxic effects. The human consumption of moderate ...
Exposure to naphthalene mothballs can cause acute hemolysis (anemia) in people with glucose-6-phosphate dehydrogenase ... Santucci, K; Shah, B. (January 2000). "Association of naphthalene with acute hemolytic anemia". Academic Emergency Medicine. 7( ... IARC points out that acute exposure causes cataracts in humans, rats, rabbits, and mice. Chronic exposure to naphthalene vapors ...
"Acute hemolysis with acute renal failure in a patient with valproic acid poisoning treated with charcoal hemoperfusion". ...
July 2016). "Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)- ... induced acute shock in mice". Scientific Reports. 6 (1): 30239. Bibcode:2016NatSR...630239F. doi:10.1038/srep30239. PMC 4957234 ...
Hemolysis may lead to numerous complications including acute kidney injury, shock, acute respiratory failure, and disseminated ... Serious and commonly fatal complications include acute kidney injury, shock, acute respiratory failure, and disseminated ... The use of corticosteroids may be a useful adjunct in treatment, as they protect blood cells against hemolysis, thereby ... Shortly after these initial symptoms appear, hemolysis develops, resulting in reduced urine output, hemoglobin in the urine or ...
In the acute phase of hemolysis, blood transfusions might be necessary, or even dialysis in acute kidney injury. Blood ... Testing can be useful after a steady state is reached (about six weeks after the most recent episode of haemolysis), including ... Monga A, Makkar RP, Arora A, Mukhopadhyay S, Gupta AK (July 2003). "Case report: Acute hepatitis E infection with coexistent ... Abnormal red blood cell breakdown (hemolysis) in 6PGD deficiency can be symptomatic in a number of ways, including the ...
Antimalarial drugs that can cause acute hemolysis in people with G6PD deficiency include primaquine, pamaquine, chloroquine, ... decreased in hemolysis); A "direct antiglobulin test" (Coombs' test) - this should be negative, as hemolysis in G6PD is not ... Red blood cell breakdown (also known as hemolysis) in G6PD deficiency can manifest in a number of ways, including the following ... High dose intravenous vitamin C has also been known to cause haemolysis in G6PD deficiency carriers; thus, G6PD deficiency ...
Hemolysis (the rupture of red blood cells) due to acute poisoning can cause anemia and hemoglobin in the urine. Damage to ... the symptoms in lead poisoning closely mimic those of acute porphyria Xu J, Yan HC, Yang B, Tong LS, Zou YX, Tian Y (April 2009 ... People who survive acute poisoning often go on to display symptoms of chronic poisoning. Chronic poisoning usually presents ... Symptoms usually develop over weeks to months as lead builds up in the body during a chronic exposure, but acute symptoms from ...
Acute kidney injury has been reported in a few cases of black mamba bites in humans as well as in animal models. Death is due ... It is more often the result of intravascular hemolysis, which occurs in about half of all cases. In other cases, ARF is often ... In some cases, kidney dialysis is necessary due to acute kidney injury, but this is not often caused by hypotension. ... "Acute renal failure following echis carinatus (saw-scaled viper) envenomation" (PDF). Indian Journal of Nephrology. 14: 177-181 ...
... is a clinical condition that can be caused by severe intravascular haemolysis or acute haemorrhagic ...
Acute hemolytic transfusion reactions due to immune hemolysis may occur in patients who have no antibodies detectable by ... Hemolysis leads to elevated bilirubin levels. After delivery bilirubin is no longer cleared (via the placenta) from the ... Like other forms of severe neonatal jaundice, there is the possibility of the neonate developing acute or chronic kernicterus, ... In the presence of significant hemolysis the smear will show schistocytes (fragmented red blood cells), reticulocytosis, and in ...
Acute hemolytic transfusion reactions due to immune hemolysis may occur in patients who have no antibodies detectable by ... Some concern exists that hemolysis may occur in these patients with a lower than 1:16 titer. Thus, if the initial titer is 1:4 ... is a condition where the passage of maternal antibodies results in the hemolysis of fetal/neonatal red cells. The antibodies ... "Acute hemolytic transfusion reactions may be either immune-mediated or nonimmune-mediated. Immune-mediated hemolytic ...
In 1930, Lederer and Brill described cases of acute hemolysis with rapid onset of anemia and rapid recovery after transfusion ... Hemolysis must also be demonstrated in the lab. The typical tests used for this are a complete blood count (CBC) with ... Autoimmune hemolysis might be a precursor of later onset systemic lupus erythematosus. The terminology used in this disease is ... Sokol RJ, Hewitt S, Stamps BK (June 1981). "Autoimmune haemolysis: an 18-year study of 865 cases referred to a regional ...
Acute hemolytic transfusion reactions due to immune hemolysis may occur in patients who have no antibodies detectable by ... Some concern exists that hemolysis may occur in these patients with a lower than 1:16 titer. Thus, if the initial titer is 1:4 ... If the fetus is Rhc positive alloimmune hemolysis can occur leading to HDN. This is similar as for Rh disease, which is usually ... "Acute hemolytic transfusion reactions may be either immune-mediated or nonimmune-mediated. Immune-mediated hemolytic ...
It is more often the result of intravascular hemolysis, which occurs in about half of all cases. In other cases, ARF is often ... ISBN 0-8069-6460-X. Ali G, Kak M, Kumar M, Bali SK, Tak SI, Hassan G, Wadhwa MB (2004). "Acute renal failure following Echis ... In some cases, kidney dialysis is necessary due to acute kidney injury (AKI), but this is not often caused by hypotension. ...
... 9527, considered by the EPA to be an acute health hazard, is stated by its manufacturer to be potentially harmful to ... may cause injury to red blood cells (hemolysis), kidney or the liver Courthouse News Service Review Of The Use Of Dispersants ... Like 9527, 9500 can cause hemolysis (rupture of blood cells) and may also cause internal bleeding. According to BP data, 20 ... Repeated or excessive exposure ... may cause injury to red blood cells (hemolysis), kidney or the liver." The manual adds: " ...
... acute HIV infection - Acute HIV Infection and Early Diseases Research Program (AIEDRP) - ADAP - ADC - adenopathy - adherence - ... hemolysis - hemophilia - hepatic - hepatic steatosis - hepatitis - hepatitis C and HIV coinfection - hepatomegaly - herpes ...
... திடீரென்ற acute அதிகப்படியான சிவப்பு அணுக்களின் அழிவு அல்லது இழப்பு , அதனால் எலும்புமச்சையால் ( Bone Marow) உடனடியாக தனது செயல் ... Hemolysis) (3) குறைவான சிவப்பு அணுக்களின் உற்பத்தி. ...
... can cause hemolysis in G6PD deficiency (an inherited deficiency), but this risk is small and the physician should not ... acute kidney injury, liver toxicity, and blindness.[27] In people with atrial fibrillation, conduction defects, or heart block ...
In hemolysis (accelerated breakdown of red blood cells), associated jaundice is caused by the hemoglobin metabolite bilirubin, ... William, C. Wilson; Grande, Christopher M.; Hoyt, David B. (2007). "Pathophysiology of acute respiratory failure". Trauma, ...
... form large colonies (>0.5 cm) after 24 hours of incubation, and produce haemolysis on blood agar; ... Recently, SDSE has been linked to post-streptococcal glomerulonephritis and acute rheumatic fever. These immunologic sequelae ... "Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population". Lancet. 356 ( ...
Because infusing a solution of low osmolality can cause problems such as hemolysis, intravenous solutions with reduced saline ... hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department."". J Popul Ther Clin ...
Two girls with acute lymphoblastic leukemia receiving chemotherapy. The girl at left has a central venous catheter inserted in ... hemolysis), hereditary disease, kidney dysfunction, nutritional deficiencies or anemia of chronic disease. Treatments to ... As chemotherapy affects cell division, tumors with high growth rates (such as acute myelogenous leukemia and the aggressive ... The most common secondary neoplasm is secondary acute myeloid leukemia, which develops primarily after treatment with ...
This is in contrast to transfusion-associated acute lung injury, in which the donor plasma has antibodies directed against the ... transfusion reaction is a type of transfusion reaction that is associated with fever but not directly with hemolysis. It is ...
... with positive erythrocyte-in-saline-agglutination test indicating an immune-mediated component to the haemolysis. Common ... In acute cases in cattle, blood transfusion may be carried out. ...
Acute hepatitis will typically have ALT and AST levels rising 20-30× normal (above 1000), and may remain significantly elevated ... The three categories are: Pre-hepaticular jaundice is caused by anything which causes an increased rate of hemolysis (breakdown ... AST levels greater than 15x tends to indicate acute hepatocellular damage. Less than this tend to indicate obstructive causes. ... In jaundice secondary to hemolysis, the increased production of bilirubin leads to the increased production of urine- ...
Hemolysis[edit]. In medicine, LDH is often used as a marker of tissue breakdown as LDH is abundant in red blood cells and can ... acute pancreatitis, HIV and lung or liver disease.[23] ... hemolysis. LDH is measured by the lactate dehydrogenase (LDH) ... Other uses are assessment of tissue breakdown in general; this is possible when there are no other indicators of hemolysis. It ... function as a marker for hemolysis. A blood sample that has been handled incorrectly can show false-positively high levels of ...
Possible class effects of antibodies include: Opsonisation, agglutination, haemolysis, complement activation, mast cell ... Animal toxicity studies : Acute toxicity testing, Repeat-dose toxicity testing, Long-term toxicity testing http://www. ...
The acute oral toxicity for chromium(VI) ranges between 1.5 and 3.3 mg/kg.[132] In the body, chromium(VI) is reduced by several ... Hemolysis, renal, and liver failure result. Aggressive dialysis can be therapeutic.[135] ... The acute toxicity of chromium(VI) is due to its strong oxidant properties. After it reaches the blood stream, it damages the ... Acute oral toxicity ranges between 50 and 150 mg/kg.[132] A 2008 review suggested that moderate uptake of chromium(III) through ...
... coagulopathy and acute renal failure: clinical cases and review" (PDF). QJM: an International Journal of Medicine. 97 (11): 717 ... "Life-threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing micro-angiopathic haemolysis, ...
Ang mga krisis na sekwestrasyong spleniko ay acute na mga makikirot na paglaki ng spleen na sanhi ng mga pagsilo na ... at cholecystitis na maaaring resulta ng labis na produksiyon ng bilirubin at presipitasyon sanhi ng tumagal na haemolysis. ... Ang sakit na sickle cell ay maaaring humantong sa mga komplikasyong acute at kroniko na ang ilan ay may mataas na rate ng ... Ang mga krisis na haemolytic ang mga acute na bumilis na pagbagsak ng lebel ng haemoglobin. Ang mga selulang pulang dugo ay ...
Possible reasons that athletics may contribute to lower iron levels includes mechanical hemolysis (destruction of red blood ... A moderate iron deficiency, in contrast, can provide protection against acute infection, especially against organisms that ... Mechanical hemolysis is most likely to occur in high-impact sports, especially among long distance runners who experience "foot ... hemolysis" from the repeated impact of their feet with the ground. Exercise-induced gastrointestinal bleeding is most likely to ...
Beta hemolysis (β-hemolysis), sometimes called complete hemolysis, is a complete lysis of red cells in the media around and ... Additional complications may be caused by GAS, namely acute rheumatic fever and acute glomerulonephritis. Rheumatic fever, a ... Other synonymous terms are incomplete hemolysis and partial hemolysis. Alpha hemolysis is caused by hydrogen peroxide produced ... When alpha hemolysis (α-hemolysis) is present, the agar under the colony is dark and greenish. Streptococcus pneumoniae and a ...
In hemolysis (accelerated breakdown of red blood cells), associated jaundice is caused by the hemoglobin metabolite bilirubin, ... William, C. Wilson; Grande, Christopher M.; Hoyt, David B. (2007). "Pathophysiology of acute respiratory failure". Trauma, ... This is an effect of intravascular hemolysis, in which hemoglobin separates from red blood cells, a form of anemia. ...
... coagulopathy and acute renal failure: clinical cases and review" (PDF). QJM: an International Journal of Medicine. 97 (11): 717 ... "Life-threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing micro-angiopathic haemolysis, ...
It may also be implicated in damage to red blood cells (haemolysis),[5][6] the liver,[7] heart,[8] endocrine glands (adrenal ... The occurrence of symptoms of bronchopulmonary dysplasia or acute respiratory distress syndrome is treated by lowering the ... Goldstein, JR; Mengel, CE (1969). "Hemolysis in mice exposed to varying levels of hyperoxia". Aerospace Medicine. 40 (1): 12-13 ... with evidence of diffuse alveolar damage and the onset of acute respiratory distress syndrome usually occurring after 48 hours ...
This type of reaction, called an acute hemolytic reaction, results in the rapid destruction (hemolysis) of the donor red blood ... The major complication is that hemoglobin released by the destruction of red blood cells can cause acute renal failure. ...
For example, approximately 1 in 6 patients with aHUS initially will present with proteinuria or hematuria without acute kidney ... hemolysis (breakdown of red blood cells), damage to multiple organs, and often, death. aHUS is not the only condition that ... hemolysis, liver dysfunction, and low platelets) syndrome, and toxic drug reaction (e.g., to cocaine, cyclosporine, or ... Patients with aHUS often present with an abrupt onset of systemic signs and symptoms such as acute kidney failure, hypertension ...
Hemolysis (the rupture of red blood cells) due to acute poisoning can cause anemia and hemoglobin in the urine.[32] Damage to ... Acute poisoningEdit. In acute poisoning, typical neurological signs are pain, muscle weakness, numbness and tingling, and, ... Chelation therapy is used in cases of acute lead poisoning,[28][unreliable medical source?] severe poisoning, and ... acute lead poisoning is rare in most countries today, but low level lead exposure is still common.[225] It was not until the ...
... acute kidney injury, and acute respiratory distress syndrome (ARDS).[6][15] ... HELLP syndrome is defined as hemolysis (microangiopathic), elevated liver enzymes (liver dysfunction), and low platelets ( ... It is particularly difficult to diagnose when pre-existing conditions such as hypertension are present.[37] Women with acute ...
It is suggested that an antibody reacting with a cisplatin-red-cell membrane is responsible for hemolysis.[10] ... acute inhibition of mechanosensitive transporters and channels without actin remodeling". Cancer Res. 70 (19): 7514-22. doi: ...
Clinical findings and normal MCV= acute hemolysis or loss without adequate time for bone marrow production to compensate**.. ... Trauma[17] or surgery, causing acute blood loss. *Gastrointestinal tract lesions,[17] causing either acute bleeds (e.g. ... Confirm by repeating reticulocyte count: ongoing combination of low reticulocyte production index, normal MCV and hemolysis or ... Many type of cancers, including colorectal cancer and cancer of the urinary bladder, may cause acute or chronic blood loss, ...
... acute medical and paediatric emergencies, critical care, sports medicine, wound care, and toxicology. ... Acute Hemolysis in the Emergency Department: Think about Clostridium perfringens!. Roustit Cécilia,1 Vallé Baptiste,1 Clouzeau ... We report a case of fatal intravascular hemolysis due to CP septicemia having a hepatic supposed starting point in the ... Nevertheless, a massive intravascular hemolysis arises only rarely in this septicemia, only from 7 to 15% of the cases. The ...
Boutboul D, Touzot F, Szalat R (2018) Understanding therapeutic emergencies in acute hemolysis. Intensive Care Med 44:482-485. ... Deuel JW, Schaer CA, Boretti FS et al (2016) Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative ...
AACC.org // ... // Clinical Chemistry // Clinical Case Studies // Confounding Case of Hemolysis in a Patient with Acute ... Confounding Case of Hemolysis in a Patient with Acute Leukemia. *Discordant Calcium and Parathyroid Hormone with Presumed ... A 12-year-old boy with refractory acute myeloid leukemia (AML) was transferred to our hospital for compassionate treatment with ...
Massive acute haemolysis is thought not to occur in the absence of trigger factors2,6 in the newborn period. ... Massive acute haemolysis in the newborn period, resulting in sudden anaemia, in the absence of trigger factor(s) in either the ... In view of his brothers fate, it was felt that twin 2 was at a high risk of death from an acute episode of haemolysis. ... However, there is no doubt from reports of trigger factor induced acute haemolysis10,11 and studies on haematological markers ...
How should patients with intradialytic hemolysis be managed?. Acute management. Stop dialysis ... Hemodialysis: Acute Complications - Intradialytic hypertension. *Hemodialysis: Acute Complications - Intradialytic hypotension ... Rimegepant Orally Dissolving Formulation Provides Rapid Relief From Acute Migraine. *Updated Evidence-Based Recommendations for ... Does this patient have intrdialytic hemolysis?. Grossly translucent hemolyzed blood in the extracorporeal blood line ...
Haemolysis in acute malaria is inevitable, the mean haemoglobin concentration usually falling within the first week, with ... Haemolysis in acute malaria is inevitable, the mean haemoglobin concentration usually falling within the first week, with ... procedure describes a simplified process for field site staff to identify and manage any cases of suspected acute haemolysis in ... Primaquine can cause additional haemolysis particularly in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, ...
Peptide inhibitor of complement C1 modulates acute intravascular hemolysis of mismatched red blood cells in rats. Transfusion. ... Peptide inhibitor of complement C1 modulates acute intravascular hemolysis of mismatched red blood cells in rats. / Kumar, ... We have recently developed a rat model of acute intravascular hemolysis showing that the classical complement pathway mediates ... CONCLUSIONS: These results demonstrate that PIC1 has efficacy in an animal model of acute intravascular hemolysis in both ...
She had features of intravascular hemolysis without features of pigment nephropathy or methemoglobinemia. She was ... Naphthalene ingestion can lead to severe intravascular hemolysis as well as methemoglobinemia. The resultant pigment ... nephropathy may also lead to acute kidney injury. ... Acute intravascular hemolysis due to naphthalene toxicity: a ... Over a week, the hemoglobin levels increased and hemolysis settled. She never went into acute kidney injury. A review after 4 ...
She had features of intravascular hemolysis without features of pigment nephropathy or methemoglobinemia. She was ... Naphthalene ingestion can lead to severe intravascular hemolysis as well as methemoglobinemia. The resultant pigment ... nephropathy may also lead to acute kidney injury. ... From: Acute intravascular hemolysis due to naphthalene toxicity ...
Types of severe renal adverse events that have been seen following IGIV therapy include acute renal failure, acute tubular ... Hematologic: Pancytopenia, leukopenia, hemolysis, positive direct antiglobulin (Coombs) test. General/Body as a Whole: Pyrexia ... See PRECAUTIONS and DOSAGE AND ADMINISTRATION sections for important information intended to reduce the risk of acute renal ... Hemolysis:. Immune Globulin Intravenous (Human) (IGIV) products can contain blood group antibodies which may act as hemolysins ...
See PRECAUTIONS and DOSAGE AND ADMINISTRATION sections for important information intended to reduce the risk of acute renal ... Hemolysis. Immune Globulin Intravenous (Human) [IGIV] products can contain blood group antibodies which may act as hemolysins ... For patients with acute or chronic Idiopathic Thrombocytopenic Purpura, a dose of 1 g/kg is recommended. The need for ... Transfusion-Related Acute Lung Injury (TRALI). There have been reports of noncardiogenic pulmonary edema (Transfusion Related ...
... acute hemolysis.. Acute blood loss. In neonates, blood loss can occur through the placenta, abruption, placenta previa, and ... encoded search term (Pediatric Acute Anemia) and Pediatric Acute Anemia What to Read Next on Medscape. Related Conditions and ... The acute development of anemia in the pediatric age group commonly occurs in 2 situations, (1) acute blood loss and (2) ... Acute silent cerebral ischemia and infarction during acute anemia in children with and without sickle cell disease. Blood. 2012 ...
17.1 Acute Renal Dysfunction and Acute Renal Failure 17.2 Thrombosis 17.3 Aseptic Meningitis Syndrome (AMS) 17.4 Hemolysis 17.5 ... 5.3 Acute Renal Dysfunction and Acute Renal Failure. Acute renal dysfunction/failure, osmotic nephrosis, and death1,2 may occur ... 13 and acute hemolysis, consistent with intravascular hemolysis, has been reported. Monitor patients for clinical signs and ... 5.6 Hemolysis 5.7 Transfusion-Related Acute Lung Injury (TRALI) 5.8 Transmissible Infectious Agents 5.9 Monitoring Laboratory ...
acute. Term used to imply that a situation or condition is more severe than usual; also used to refer to a disease having run a ... The hemolysis (destruction) of red blood cells results in the release of hemoglobin, which can lead to jaundice, and further on ...
acute. Term used to imply that a situation or condition is more severe than usual; also used to refer to a disease having run a ... The hemolysis (destruction) of red blood cells results in the release of hemoglobin, which can lead to jaundice, and to anemia ... In acute cases, IMHA can be a life-threatening condition requiring emergency treatment. In such cases your cat will be ...
Acute kidney injury. A sharp increase in serum creatinine levels was noted during the first days of diarrhoea onset, and by day ... Haemolysis and thrombocytopenia. At the onset of diarrhoea the levels of lactate dehydrogenase were slightly raised and ... Haemolytic uraemic syndrome associated with E coli O104:H4 is an acute self limited disease with a high percentage of patients ... Despite the severity of the disease during the acute phase, most of the patients recovered completely and only five were still ...
Clinical signs & symptoms of acute leukemia. Take Quiz. Initial management & tumor lysis syndrome in acute leukemia. Take Quiz ... Drug-induced hemolysis: Pathophysiology, diagnosis, & treatment. Take Quiz. Prognosis & management of megaloblastic anemia. ... Managing Ph-positive acute lymphoblastic leukemia. Take Quiz. Myelodysplastic syndrome: Diagnosis, risk-stratification, and ... In drug-induced oxidative hemolysis erythrocytes undergo _______________ oxidative stress during the course of normal reactions ...
... and an emerging urinary biomarker of acute kidney injury (AKI). Based on the hypothesis that elevated... ... Acute kidney injury Chitinase-3 like 1 Nitric oxide therapy Adjunctive therapy Mortality Inflammation Endothelium Hemolysis ... Acute kidney injury and its association with in-hospital mortality among children with acute infections. Pediatr Nephrol. 2013; ... Kidney Disease: Improving Global Outcomes (KDIGO), Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute ...
Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome. Hemolysis, elevated liver enzymes, and low platelets (HELLP) ... Acute Fatty Liver of Pregnancy. The prevalence of acute fatty liver of pregnancy (AFLP), in which microvesicular fatty ... Pregnant women presenting with acute hepatitis should be tested for common etiologies of acute liver injury including viral ... and hemolysis and elevated liver enzymes and low platelets (HELLP) syndrome. [1] Liver disease such as acute viral hepatitis ...
Acute hemolysis may occur in a patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency under certain circumstances. ... Risk Factors for Acute Hemolysis in Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency. ... Acute hemolysis may occur in a patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency under certain circumstances. ...
When hemolysis does occur, it is typically immune mediated and extravascular, but can be intravascular with the degree of ... We report a case of a healthy 27-year-old woman who presented with jaundice and non-immune mediated intravascular hemolysis as ... should be considered in the differential diagnosis of patients with Coombs negative intravascular hemolysis. ... Acute Cytomegalovirus (CMV) infection seldom presents with hemolytic anemia in an immunocompetent host. ...
Prevention and treatment of acute malnutrition in emergencies and humanitarian crises * Paracetamol protects kidney in severe ... No evidence that chloroquine or hydroxychloroquine induce hemolysis in G6PD deficiency * Integration of HIV services with ... Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis * Community engagement for the ... Case-control study of use of personal protective measures and risk for severe acute respiratory syndrome coronavirus 2 ...
This causes acute and often severe anemia.. The part of red blood cells that carries oxygen (hemoglobin) is released into the ... Causes of hemolysis include:. *A lack of certain proteins inside red blood cells ...
In the patients with major haemolysis, the changes correlated to the haemolysis over time. Hence, a similar mechanism for ... normal erythrocyte senescence and other forms of acute haemolysis. ... Most subjects, however, showed minor signs of intravascular haemolysis. The plasma Hb was ≪1% of blood Hb and haemoglobinuria ... Haemoglobinuria was, however, a marker of severe haemolysis, since the maximum blood Hb loss in children without ...
HMS-Related Hemolysis after Acute Attacks of Plasmodium vivax Malaria Oriol Mitjà, Russell Hays, James Malken, Anthony Ipai, ... Hematologic changes in acute and convalescent uncomplicated Plasmodium falciparum malaria have not been well studied, ...
Acute. A controlled study was performed in children in which Carimune® was compared with steroids for the treatment of acute ( ... Hemolysis. Immune Globulin Intravenous (Human) (IGIV) products can contain blood group antibodies which may act as hemolysins ... Acute ITP - Childhood. In acute ITP of childhood, if an initial platelet count response to the first two doses is adequate (30- ... Types of severe renal adverse events that have been seen following IGIV therapy include: acute renal failure, acute tubular ...
This study evaluates the clinical features of acute hemolysis in children with G6PD deficiency. Materials and Methods: Seventy ... icterus and dark urine were the three important symptoms in G6PD patients with acute hemolysis. There was no correlation ... This study evaluates the clinical features of acute hemolysis in children with G6PD deficiency. Materials and Methods: Seventy ... " Honar, N., Javanmardi, H., Saki, F., Rezaeefard, A., Shahriari, M. Clinical Manifestations of Acute Hemolysis in Children with ...
Statins Can Lead to Acute Hemolysis. , 2018; 16(2): 123-123.. Mojdeh Moghadasi and Zohreh Maghsoomi*. DOI: 10.2174/ ...
The capacity of this parameter to predict haemolysis appears to be limited in patients with liver cirrhosis and decr … ... is a reliable marker for the instant diagnosis of accelerated red cell destruction irrespective of the site of haemolysis or ... In patients with haemolysis and a concomitant acute-phase response, however, haemolysis-dependent haptoglobin depletion was not ... Influence of clinical factors on the haemolysis marker haptoglobin Eur J Clin Invest. 2006 Mar;36(3):202-9. doi: 10.1111/j.1365 ...
  • BACKGROUND: Acute hemolytic transfusion reactions have a broad clinical presentation from mild and transitory signs and symptoms to shock, disseminated intravascular coagulation, renal failure, and death. (elsevier.com)
  • Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur with the administration of Immune Globulin Intravenous (Human) (IGIV) products in predisposed patients. (nih.gov)
  • Renal dysfunction and acute renal failure occur more commonly in patients receiving IGIV products containing sucrose. (nih.gov)
  • For patients at risk of thrombosis, renal dysfunction or acute renal failure, administer Carimune NF at the minimum dose and infusion rate practicable. (nih.gov)
  • The incidence of HELLP syndrome complicated with acute renal failure (ARF) is unknown because of a paucity of large series dealing with this subject. (biomedcentral.com)
  • B: acute renal dysfunction, with a maximum serum creatinine level between 100 and 200 μmol/l at day 1 of ICU admission. (biomedcentral.com)
  • Acute renal dysfunction is a strong independent denominator of survival in the critically ill obstetric patient. (biomedcentral.com)
  • A frequent adverse effect related to massive hemolysis is the renal injury and inflammation. (frontiersin.org)
  • We also provide detailed characterization of renal manifestations associated with acute intravascular hemolysis, which may be mediated by hemolysis-derived products upstream of heme release. (frontiersin.org)
  • This analysis provides a platform for further investigations of hemolytic diseases and associated renal injury and the evaluation of novel therapeutic strategies that target intravascular hemolysis. (frontiersin.org)
  • Our aim was to evaluate the clinical profile, treatment, and outcome of ceftriaxone-associated postrenal acute renal failure (PARF) in children. (aappublications.org)
  • Renal stone formation with ceftriaxone therapy can result in postrenal acute renal failure in children. (aappublications.org)
  • 5 Severe nephrolithiasis can cause postrenal acute renal failure (PARF). (aappublications.org)
  • Examples include acute and chronic infections, malignancy and renal failure. (labcorp.com)
  • This review reinforces the suggestion that patients should be closely monitored for signs and symptoms of acute hemoglobinemia or hemoglobinuria, clinically compromising anemia, and renal insufficiency following anti-D IGIV administration for ITP or other thrombocytopenias.It further suggests that it may be prudent to monitor patients experiencing those events for signs and symptoms of DIC . (traqprogram.ca)
  • Likewise, the association of ES and acute renal failure is equally uncommon. (hindawi.com)
  • Acute renal failure, haemolysis, and thrombocytopenia. (inchem.org)
  • We describe three neonates with G6PD deficiency who developed severe hyperbilirubinaemia requiring exchange transfusion because of massive acute haemolysis, in the absence of any obvious blood group incompatibilities, infection, or ingestion of oxidising agents known to trigger haemolysis by either the mother or infant. (bmj.com)
  • Naphthalene ingestion can lead to severe intravascular hemolysis as well as methemoglobinemia. (biomedcentral.com)
  • Patients with acute anemia are overtly symptomatic when the condition is severe, whereas those with chronic anemia may go undiagnosed because they are asymptomatic relative to the degree of anemia. (medscape.com)
  • Patients with acute and severe anemia appear in distress, with tachycardia, tachypnea, and hypovolemia. (medscape.com)
  • Have medications such as epinephrine available immediately to treat any acute severe hypersensitivity reactions. (nih.gov)
  • Chitinase-3-like 1 (CHI3L1) is a glycoprotein elevated in paediatric severe malaria, and an emerging urinary biomarker of acute kidney injury (AKI). (springer.com)
  • CHI3L1 is a novel biomarker of malaria-associated AKI and an independent risk factor for mortality that is associated with well-established pathways of severe malaria pathogenesis including inflammation, endothelial activation, and haemolysis. (springer.com)
  • When hemolysis does occur, it is typically immune mediated and extravascular, but can be intravascular with the degree of anemia ranging from mild to severe. (scholars.direct)
  • The degree of hemolysis ranges from mild to severe and is dependent on the immune status of the host. (scholars.direct)
  • This causes acute and often severe anemia . (medlineplus.gov)
  • More than 60 percent of patients had moderate to severe hemolysis with Hb less than 7 gr/dL. (ac.ir)
  • Severe hemolysis and transfusion reactions after treatment with BGB-3111 and PD-1 antibody for Waldenström macroglobulinemia 29439186 2019 03 06 1592-8721 103 5 2018 05 Haematologica Haematologica Severe hemolysis and transfusion reactions after treatment with BGB-3111 and PD-1 antibody for Waldenström macroglobulinemia. (tripdatabase.com)
  • Intravascular haemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury. (ox.ac.uk)
  • However, the roles of intravascular haemolysis and nitric oxide (NO)-dependent endothelial dysfunction, important features of severe falciparum malaria, have not been evaluated, nor their role in acute kidney injury (AKI). (ox.ac.uk)
  • Our findings suggest that haemolysis-mediated endothelial activation and release of WPB constituents is likely a key contributor to end-organ dysfunction, including AKI, in severe knowlesi malaria. (ox.ac.uk)
  • If there is massive bleeding from a wound or other lesion, the body may lose enough blood to cause severe and acute anemia, which is often accompanied by shock. (thefreedictionary.com)
  • Complete disappearance of gallstones and the development of severe biliary pain, acute cholecystitis, or acute pancreatitis. (acpjc.org)
  • Objectives To evaluate the haematological findings of patients with severe acute respiratory syndrome (SARS). (bmj.com)
  • An outbreak of severe acute respiratory syndrome (SARS) has recently been reported from Hong Kong. (bmj.com)
  • In a large study of 272 patients, 3 hemolysis was the main adverse event but decreases in hemoglobin values averaged less than 1 g/dL(10 g/L). The anemia was transient and never severe enough to require a transfusion. (traqprogram.ca)
  • Although the severe sequelae of IV RhIG are not proven to involve intravascular hemolysis (IVH), rapid onset of hemoglobinuria is usually associated with C9-binding antibodies such as anti-A and anti-B and not the non-complement-binding anti-D. Multiple mechanisms may occur or interact and different mechanisms or explanations may account for hemoglobinemia and/or hemoglobinuria in different patients. (traqprogram.ca)
  • Kidd antibodies are dangerous as they are capable of causing severe acute hemolytic transfusion reactions. (wikipedia.org)
  • Hyperbilirubinaemia in neonates with G6PD deficiency is thought to be secondary to reduced hepatic conjugation and excretion of bilirubin 1, 2, 4, 5 rather than increased bilirubin production resulting from haemolysis. (bmj.com)
  • Primaquine can cause additional haemolysis particularly in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, therefore clinical staff need to be vigilant for the signs and symptoms of haemolysis and the risk of trial subjects becoming anaemic. (wwarn.org)
  • Hemolysis occurs usually in susceptible individuals such as in those who are G6PD deficient. (biomedcentral.com)
  • This study evaluates the clinical features of acute hemolysis in children with G6PD deficiency. (ac.ir)
  • In this study, pallor, icterus and dark urine were the three important symptoms in G6PD patients with acute hemolysis. (ac.ir)
  • Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. (biomedcentral.com)
  • We report on a 6-year-old boy, previously undiagnosed with G6PD deficiency, who developed life-threatening haemolysis after application of henna to his skin. (who.int)
  • A presumptive diagnosis of acute haemolysis due to G6PD deficiency was made and the child received 1 blood transfusion and folic acid after which he recovered fully. (who.int)
  • Less commonly, CMV infection may result in hematological complications including hemolysis, thrombocytopenia, disseminated intravascular coagulation and pancytopenia [ 3 , 4 ]. (scholars.direct)
  • Giving bexarotene together with GM-CSF may be an effective treatment for myelodysplastic syndrome ( MDS ) or acute myeloid leukemia. (clinicaltrials.gov)
  • PURPOSE: This phase II trial is studying how well giving bexarotene together with GM-CSF works in treating patients with MDS or acute myeloid leukemia. (clinicaltrials.gov)
  • Assess the clinical response in patients with myelodysplastic syndromes or acute myeloid leukemia treated with bexarotene and sargramostim (GM-CSF). (clinicaltrials.gov)
  • Clinical implications of subclonal TP53 mutations in acute myeloid leukemia. (nih.gov)
  • Randomized phase III, multicentre, open label clinical trial to compare pevonedistat in combination with azacytidine versus azacytidine alone, which can be considered a standard of care for patients with newly diagnosed acute myeloid leukemia not eligible for intensive chemotherapy (thus not eligible for an allogeneic hematopoietic stem cell transplant. (clinicaltrials.gov)
  • Prospective, 1:1 randomized multicentre, open label, phase III clinical trial to evaluate efficacy and safety of pevonedistat in combination with azacytidine versus azacytidine in the treatment of naïve adult patients with acute myeloid leukemia who are not eligible for standard induction therapy due to age, co-morbidities or risk-factors. (clinicaltrials.gov)
  • Acute myeloid leukemia (promyelocytic or monocytic subtypes), mucinous adenocarcinomas. (renalandurologynews.com)
  • Primary: To determine the safety of Plerixafor and Filgrastim (G-CSF) in combination with sorafenib for treatment of refractory or relapsed myeloid leukemias with mutated fms-like tyrosine kinase receptor-3 (FLT3), and of elderly patients with acute myelogenous leukemia (AML) FLT3 mutations who are not eligible for frontline standard therapy, or who refuse to be treated with intensive chemotherapy. (mdanderson.org)
  • [ 1 ] Liver disease such as acute viral hepatitis can occur in pregnancy, and pregnancy may occur in a patient with underlying chronic liver disease, including patients with cirrhosis and portal hypertension, and patients who have undergone liver transplantation. (medscape.com)
  • Likewise, anaemia owing to bone marrow failure, acute gastrointestinal or chronic diffuse blood loss, and end-stage kidney disease were associated with normal haptoglobin levels. (nih.gov)
  • describe characteristic clinical presentations of patients with acute and chronic chromium exposure. (cdc.gov)
  • Acute poisoning is likely to occur through the oral route, whereas chronic poisoning is mainly from inhalation or skin contact [Meditext 2005]. (cdc.gov)
  • Computed tomography scan revealed an acute on chronic subdural haemorrhage. (beds.ac.uk)
  • Chronic hemodialysis patients manifest acute cardiovascular complications such as intradialytic hypotension, intradialytic hypertension, arrhythmias, acute coronary syndromes and sudden death. (spandidos-publications.com)
  • To increase platelet counts in RhD-positive nonsplenectomized patients with the following conditions: acute ITP (children), chronic ITP (adults and children), or ITP secondary to HIV infection (adults and children). (drugs.com)
  • Causes can be classified as acute or chronic, systemic or localized. (unboundmedicine.com)
  • Hemolysis presents as acute or chronic anemia, reticulocytosis, or jaundice. (aafp.org)
  • Sickle cell anemia and thalassemia are hemoglobinopathies characterized by chronic hemolysis. (aafp.org)
  • Deuel JW, Schaer CA, Boretti FS et al (2016) Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response. (springer.com)
  • Compared to IVIG and saline controls, PIC1-treated animals demonstrated decreased hemolysis and protection from acute kidney injury. (elsevier.com)
  • The resultant pigment nephropathy may also lead to acute kidney injury. (biomedcentral.com)
  • She never went into acute kidney injury. (biomedcentral.com)
  • Well-characterized animal models of hemolysis with kidney impairment are needed to investigate how hemolysis drives kidney injury and to test novel therapeutic strategies. (frontiersin.org)
  • Here we characterized the pathological processes leading to acute kidney injury and inflammation during massive intravascular hemolysis, using a mouse model of phenylhydrazine (PHZ)-triggered erythrocyte destruction. (frontiersin.org)
  • After transfusion of red blood cells (RBCs) via syringe in the operating room, each patient experienced discolored urine, laboratory evidence of hemolysis , and acute kidney injury. (tripdatabase.com)
  • Heart, liver, and kidney effects may be secondary to hemolysis. (cdc.gov)
  • Angiopoietin-2 and osteoprotegerin were both independent risk factors for acute kidney injury. (ox.ac.uk)
  • We present a case of a 7-year-old girl with ES who developed acute kidney injury in the setting of intravascular hemolysis and had widespread intratubular hemoglobin casts. (hindawi.com)
  • Analysis of the walk-PHaSST cohort also showed a positive association between TSP1 levels and hydroxyurea use (r = 0.14, P = 0.003), and confirmed the negative associations with the severity of hemolysis. (nih.gov)
  • The acute development of anemia in the pediatric age group commonly occurs in 2 situations, (1) acute blood loss and (2) acute hemolysis. (medscape.com)
  • Monitor patients for hemolysis and hemolytic anemia. (nih.gov)
  • The hemolysis (destruction) of red blood cells results in the release of hemoglobin , which can lead to jaundice , and further on to anemia when the body cannot produce enough new red blood cells to replace the ones being destroyed. (petmd.com)
  • Acute Cytomegalovirus (CMV) infection seldom presents with hemolytic anemia in an immunocompetent host. (scholars.direct)
  • Aniline may also cause the destruction of red blood cells, which manifests as acute or delayed hemolytic anemia. (cdc.gov)
  • Confirm that the anemia is due to hemolysis. (renalandurologynews.com)
  • Avoid empiric red blood cell and platelet transfusion unless the etiology of hemolysis is definitively known, or if life-threatening bleeding or anemia is present. (renalandurologynews.com)
  • Microangiopathic hemolytic anemia occurs when the red cell membrane is damaged in circulation, leading to intravascular hemolysis and the appearance of schistocytes. (aafp.org)
  • While hemolysis can be a lifelong asymptomatic condition, it most often presents as anemia when erythrocytosis cannot match the pace of red cell destruction. (aafp.org)
  • Anemia most often is discovered through laboratory tests, but the history and physical examination can provide important clues about the presence of hemolysis and its underlying cause. (aafp.org)
  • Along with anemia, a characteristic laboratory feature of hemolysis is reticulocytosis, the normal response of the bone marrow to the peripheral loss of red blood cells. (aafp.org)
  • The anemia of hemolysis usually is normocytic, although a marked reticulocytosis can lead to an elevated measurement of mean corpuscular volume, because the average mean corpuscular volume of a reticulocyte is 150 fL. (aafp.org)
  • Massive acute haemolysis is thought not to occur in the absence of trigger factors 2, 6 in the newborn period. (bmj.com)
  • Acute complications occur quite frequently during dialysis. (spandidos-publications.com)
  • The acute complications occur quite frequently during dialysis, and are caused by complex mechanisms, which are insufficiently known ( 8 ). (spandidos-publications.com)
  • Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged heavy alcohol use. (wikipedia.org)
  • Following transfusion, a subsequent robust antibody response in the patient can occur (anamnestic response), resulting in hemolysis of the transfused red blood cells. (wikipedia.org)
  • Clostridium perfringens (CP) gives several clinical settings, from an asymptomatic to a massive intravascular hemolysis. (hindawi.com)
  • Nevertheless, a massive intravascular hemolysis arises only rarely in this septicemia, only from 7 to 15% of the cases. (hindawi.com)
  • Over a week, the hemoglobin levels increased and hemolysis settled. (biomedcentral.com)
  • In drug-induced oxidative hemolysis erythrocytes undergo _______________ oxidative stress during the course of normal reactions involving oxygenation and deoxygenation of hemoglobin. (mdedge.com)
  • Measurements included hematocrit (Hct), free hemoglobin, and visual hemolysis index. (tripdatabase.com)
  • 0.0001) and hemoglobin concentration (r = 0.49, P = 0.01), and negatively with markers of hemolysis, such as LDH (r = -0.50, P = 0.009). (nih.gov)
  • In the patient with the most dramatic drop in hemoglobin,the maximum decrease of 7.6 g/dL (76 g/L) occurred 8 days after treatment and she experienced ongoing hemolysis for at least 20 days, as evidenced by persistent hemoglobinuria. (traqprogram.ca)
  • however, the development of intratubular hemoglobin casts (hemoglobin cast nephropathy) in the setting of acute hemolysis is uncommon. (hindawi.com)
  • Bilirubin is an orange yellow bile pigment that is produced as a byproduct of hemoglobin as red blood cells break down (hemolysis). (wikipedia.org)
  • Though the origins of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are rooted in human antiquity, the presence of drug-induced hemolysis in individuals subsequently felt to have G-6-PD deficiency was first reported in 1926 and the biochemical lesion responsible for this phenomenon elucidated in 1956 (1). (annals.org)
  • Glucose-6-phosphate dehydrogenase deficiency leads to hemolysis in the presence of oxidative stress. (aafp.org)
  • Boutboul D, Touzot F, Szalat R (2018) Understanding therapeutic emergencies in acute hemolysis. (springer.com)
  • The liver diseases unique to pregnancy include hyperemesis gravidarum, acute fatty liver of pregnancy (AFLP), intrahepatic cholestasis of pregnancy (ICP), and hemolysis and elevated liver enzymes and low platelets (HELLP) syndrome. (medscape.com)
  • The HELLP syndrome (haemolysis, elevated liver enzymes, and low-platelet count) occurs in about 0.5 to 0.9% of all pregnancies. (beds.ac.uk)
  • With occurrence of thrombocytopaenia, it signals for several potentially lethal conditions such as complete or partial HELLP syndrome, thrombotic thrombocytopaenic purpura and acute fatty liver of pregnancy. (beds.ac.uk)
  • Development of thrombocytopaenia can be considered as an early warning sign for HELLP, thrombotic thrombocytopaenic purpura or acute fatty liver of pregnancy which are lethal conditions. (beds.ac.uk)
  • Mitochondrial fatty acid oxidation disorders in an affected fetus are associated with maternal diseases of pregnancy, including preeclampsia, acute fatty liver of pregnancy, and the hemolysis, elevated liver enzymes, and low platelets syndrome called HELLP. (physiology.org)
  • Extravascular hemolysis results in erythrocyte degradation in the reticuloendothelial system, while Intravascular Hemolysis (IVH) occurs when RBCs lyse in circulation secondary to shear stress, cell membrane abnormalities, or antibody mediated complement activation. (scholars.direct)
  • The more common extravascular hemolysis is the removal and destruction of red blood cells with membrane alterations by the macrophages of the spleen and liver. (aafp.org)
  • More often, however, Kidd antibodies cause acute extravascular hemolysis. (wikipedia.org)
  • In patients with a CF-LVAD (HeartMate II), thromboembolic events and/or pump thrombosis are associated with symptoms and signs of acute haemolysis as manifested by a high LDH, elevated pump power and decreased pulse index, especially in the context of an infection. (bsl.nl)
  • All these symptoms and signs were suggestive of an acute haemolytic process. (who.int)
  • It is suggestive to prevent parents of sugh patients of favea consumption, which in turn decreases the rate of acute hemolysis, its complications, complications of transfusion and hospitalization in endemic area of Iran. (ac.ir)
  • Despite advances in pump technology, thromboembolic events/acute pump thrombosis remain potentially life-threatening complications in patients with continuous-flow left ventricular assist devices (CF-LVAD). (bsl.nl)
  • Bleeding complications occurred when therapy was used closer to the operative period.Argatroban can be a viable option to treat patients with hemolysis from suspected device thrombosis in patients with HeartMate II continuous flow left ventricular assisted device. (biomedsearch.com)
  • All three patients suffered an episode of massive acute haemolysis, in the absence of blood group incompatibilities, infection, or ingestion of oxidising agents known to trigger haemolysis. (bmj.com)
  • We report a case of a healthy 27-year-old woman who presented with jaundice and non-immune mediated intravascular hemolysis as an initial feature of acute CMV infection. (scholars.direct)
  • However, studies have described hemolysis in immunocompetent individuals with primary CMV infection [ 5 - 8 ]. (scholars.direct)
  • We report a case of acute CMV infection presenting with Coombs negative IVH in an immunocompetent host. (scholars.direct)
  • Acute infection of unstable systemic inflammatory disease. (clinicaltrials.gov)
  • Low iron level may not indicate iron deficiency in acute infection with leukocytosis. (labcorp.com)
  • In the United States, hemolysis induced by infection or drugs is the most common clinical manifestation of G-6-PD deficiency (2). (annals.org)
  • Classic Guillain-Barré syndrome (GBS) is an acute to sub-acute onset ascending, flaccid, symmetric, areflexic weakness syndrome, often associated with autonomic instability, typically occurring within days to weeks of an antecedent infection. (oncologynurseadvisor.com)
  • The classic acute inflammatory demyelinating polyneuropathy form of Guillain-Barré syndrome is an acute- to subacute onset of progressive, flaccid, areflexic paralysis, often preceded by a recent infection, and associated with paresthesias. (oncologynurseadvisor.com)
  • Most subjects, however, showed minor signs of intravascular haemolysis. (aku.edu)
  • Plasma haptoglobin depletion is a reliable marker for the instant diagnosis of accelerated red cell destruction irrespective of the site of haemolysis or the presence of inflammation. (nih.gov)
  • Locus coeruleus (LC)-derived noradrenaline is important in cognition and decreases with age, but the impact of prior noradrenaline deficiency on vulnerability to inflammation-induced acute cognitive dysfunction is unclear. (physiciansweekly.com)
  • Here we assessed whether noradrenergic depletion, in female mice, impacted upon inflammation, locomotor activity and working memory directly after acute systemic immune challenge with bacterial lipopolysaccharide (LPS), a paradigm we have previously used to capture delirium-like acute cognitive deficits. (physiciansweekly.com)
  • Hemolysis is the premature destruction or removal of Red Blood Cells (RBCs) from circulation. (scholars.direct)
  • Constant manual pressure (1.43 ± 0.49 mL/sec) or syringe pump (2 mL/min) was used and a subset was timed.The valve increased hemolysis during manual transfusion using both catheters with washed and unwashed RBCs. (tripdatabase.com)
  • Mechanical hemolysis is due to excessive mechanical forces that damage red blood cells (RBCs). (oncologynurseadvisor.com)
  • Notably, rats receiving PIC1 after initiation of transfusion showed similar decreases in hemolysis as animals receiving PIC1 before transfusion. (elsevier.com)
  • It occurs occasionally in acute conditions, namely blood loss and hemolysis. (wikipedia.org)
  • Acute DIC occurs when rapid consumption of coagulation factors and platelets cannot be adequately compensated. (unboundmedicine.com)
  • If transfusion-related acute lung injury is suspected, test the product and patient for antineutrophil antibodies. (nih.gov)
  • This course covers important types of transfusion reactions, including acute hemolytic transfusion reactions, transfusion-related acute lung injury, and transfusion-associated graft versus host disease. (medialab.com)
  • Which type of antibodies are known to cause transfusion-related acute lung injury (TRALI) reactions? (medialab.com)
  • An acute hemolytic transfusion reaction (AHTR) may be caused by which of the following? (medialab.com)
  • The emergency physician has to think about this complication in case of hemoglobinuria and/or signs of hemolysis associated with a septic syndrome. (hindawi.com)
  • In September 2005 the FDA published thefirst case series of DIC associated with acute hemoglobinemia or hemoglobinuria following IV RhIG administered for ITP. (traqprogram.ca)
  • It should also be noted that previous uneventful administration of anti-D IGIV does not preclude the occurrence of acute hemoglobinemia or hemoglobinuria following subsequent administration of anti-D IGIV. (traqprogram.ca)
  • 160,000 µL (normal 50,000-150,000 µL), absolute reticulocytes 4.3% (normal 0.5-1.5%), LDH 660 U/L (normal 105-333 U/L) and undetectable haptoglobin, suggesting intravascular hemolysis. (scholars.direct)
  • Plasma haptoglobin determination is clinically used as parameter for haemolysis. (nih.gov)
  • To date, however, the influence of the mode of haemolysis (extravascular vs. intravascular) and of nonhaemolytic conditions on haptoglobin concentration and its reliability as a haemolysis marker remain poorly defined. (nih.gov)
  • All studied types of haemolytic disease (n = 16) were associated with markedly decreased plasma haptoglobin levels, without significant differences between intravascular vs. predominantly extravascular haemolysis. (nih.gov)
  • In patients with haemolysis and a concomitant acute-phase response, however, haemolysis-dependent haptoglobin depletion was not attenuated. (nih.gov)
  • Interestingly, patients with a strongly positive direct antiglobulin test or high cold agglutinin titre but no further evidence for haemolysis had normal haptoglobin values. (nih.gov)
  • The capacity of this parameter to predict haemolysis appears to be limited in patients with liver cirrhosis and decreased haptoglobin production only. (nih.gov)
  • Mechanisms leading to hemolysis include direct invasion of erythrocytes by the organism ( Plasmodium falciparum ), release of hemolytic toxins that cause RBC phospholipid membrane degradation ( Clostridium perfringes ), or autoantibody development and immune destruction ( Mycoplasma pneumoniae , Epstein Barr virus (EBV)) [ 2 ]. (scholars.direct)
  • Nevertheless, when bilirubin levels become exceedingly high, the substance may move out of the blood, cross the blood brain barrier, and collect in brain tissue, damaging the baby's brain cells, a condition known as acute bilirubin encephalopathy. (wikipedia.org)
  • If acute bilirubin encephalopathy is not addressed promptly, Kernicterus syndrome can develop and cause permanent brain damage. (wikipedia.org)
  • Hemolysis is defined as red blood cell destruction. (renalandurologynews.com)
  • Hemolysis is the destruction or removal of red blood cells from the circulation before their normal life span of 120 days. (aafp.org)
  • Intravascular hemolysis is the destruction of red blood cells in the circulation with the release of cell contents into the plasma. (aafp.org)
  • Argatroban as novel therapy for suspected thrombosis in patients with continuous flow left ventricle assist device and hemolysis. (biomedsearch.com)
  • Jaundice and, occasionally, dark urine may be present with significant hemolysis. (medscape.com)
  • A previously healthy 27-year-old Caucasian woman of Italian, Belgian, and German descent was referred to Mayo Clinic for further evaluation of acute jaundice which began three weeks earlier. (scholars.direct)
  • Hemolysis also can manifest as jaundice, cholelithiasis, or isolated reticulocytosis. (aafp.org)
  • What testing is required for a diagnosis of acute rheumatic fever (ARF)? (medscape.com)
  • Device thrombosis remains a therapeutic dilemma and limited data is available for use of direct thrombin inhibitors as a treatment option.We performed a review of literature and present a series of four patients with suspected left ventricular assisted device associated thrombosis, manifesting as hemolysis, who were treated empirically with argotraban, a direct thrombin inhibitor with ability to interact with both free and clot-bound thrombin. (biomedsearch.com)
  • Hemolysis risk after packed red blood cells transfusion with infusion pumps To evaluate the hemolysis biomarkers of packed red blood cells transfused by two different linear peristaltic infusion pumps at two infusion rates.An experimental and randomized study was designed simulating the clinical practice of transfusion . (tripdatabase.com)
  • Acute neuroinflammation, sickness behavior and working memory in response to acute systemic challenge with LPS following noradrenergic lesion in mice. (physiciansweekly.com)
  • Her blood picture featured normochromic normocytic red cells with reduced count, blister cells, bite cells, and red cell fragments suggestive of intravascular hemolysis (Fig. 1 ). (biomedcentral.com)
  • Added less-specific case definition categories for OPTIONAL reporting of cases that do not fully meet CDC case criteria for the following reactions: hypotension, febrile non-hemolytic, acute hemolytic and delayed hemolytic. (cdc.gov)
  • The objectives of this study are as follows: Primary objective: The primary objective of the study is to determine the MTD and the RD of lurbinectedin (PM01183) administered as 1-hour i.v. infusion on 3 consecutive days (Days 1-3) to patients with advanced acute leukemia or relapsed/refractory myelodysplastic syndrome (MDS) failing previous treatment with hypomethlating agents. (mdanderson.org)
  • Gilbert's syndrome or hemolysis). (mdanderson.org)
  • Sweet syndrome, or acute febrile neutrophilic dermatosis, is a neutrophilic dermatosis rarely seen in the pediatric population, accounting for only 5% to 8% of all cases of Sweet syndrome. (renalandurologynews.com)
  • Haemolysis in acute malaria is inevitable, the mean haemoglobin concentration usually falling within the first week, with recovery usually taking 28-42 days. (wwarn.org)
  • Acute haemolysis in childhood falciparum malaria" by H. Ekvall, P. Arese et al. (aku.edu)
  • Acute haemolysis associated with clinical episodes of high-level Plasmodium falciparum parasitaemia was studied in 20 children from an holoendemic area (coastal Tanzania). (aku.edu)