Acute Generalized Exanthematous Pustulosis
Exanthema
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
Drug Eruptions
Skin Diseases, Vesiculobullous
Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)
Erythema
Stevens-Johnson Syndrome
Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
Acquired Hyperostosis Syndrome
Syndrome consisting of SYNOVITIS; ACNE CONGLOBATA; PALMOPLANTAR PUSTULOSIS; HYPEROSTOSIS; and OSTEITIS. The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome.
Sternocostal Joints
Hyperostosis, Sternocostoclavicular
A rare, benign rheumatologic disorder or syndrome characterized by hyperostosis and soft tissue ossification between the clavicles and the anterior part of the upper ribs. It is often associated with the dermatologic disorder palmoplantar pustulosis, particularly in Japan. Careful diagnosis is required to distinguish it from psoriatic arthritis, OSTEITIS DEFORMANS, and other diseases. Spondylitis of pustulosis palmaris et plantaris is one of the possible causes; also, evidence suggests one origin may be bone infection. Bone imaging is especially useful for diagnosis. It was originally described by Sonozaki in 1974.
Sternoclavicular Joint
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Localized acute generalized exanthematous pustulosis with amoxicillin and clavulanic acid. (1/6)
Acute generalized exanthematous pustulosis (AGEP) is a rare skin disorder, characterized by acute development of numerous, pin-head sized, nonfollicular pustules on erythematous skin, with high fever and neutrophilia. The condition is frequently caused by hypersensitivity reaction to drugs or viral infections. Diagnosis is established according to clinical and histological criteria. Herein, we report a 17-year-old girl with localized AGEP related to the use of amoxicillin-clavulanate. (+info)Acute generalized exanthematous pustulosis due to oral use of blue dyes. (2/6)
(+info)A recent update of pharmacogenomics in drug-induced severe skin reactions. (3/6)
In some adverse drug reactions (ADRs), genetic predisposition plays a significant role in pathogenesis, and the skin is the most frequently reported target. These severe cutaneous ADRs include bullous fixed drug eruptions (FDE), acute generalized exanthematous pustulosis (AGEP), drug-induced hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). The putative contribution of individual effector cells in drug hypersensitivity is briefly mentioned. To trigger these drug hypersensitivities, certain class I HLA alleles (e.g., HLA-A and HLA-B alleles) and certain class II HLA alleles (e.g., HLA-DR alleles) have been recently found to be the genetic determinants. One of the best characterized examples mentioned in this article is HLA-B*1502 to determine the incidence of carbamazepine-induced SJS. How drugs are processed and presented by these HLA alleles to activate immune responses has been explained by several hypotheses. Further implication of pharmagenomic findings to prevent drug-induced severe skin reactions can be achieved by pre-screening putative risk HLA alleles before using drugs. (+info)Two cases of acute generalized exanthematous pustulosis related to oral terbinafine and an analysis of the clinical reaction pattern. (4/6)
Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern characterized by the rapid appearance of widespread sterile, nonfollicular pustules arising within edematous erythematous skin. This aseptic pustular eruption is commonly accompanied by leukocytosis and fever and usually follows recent administration of oral or parenteral drugs. We report two cases of terbinafine-induced AGEP in male patients. Both patients developed a generalized erythroderma with scaling and pruritic pustules 7 and 14 days following initiation of oral terbinafine. With immediate discontinuation of terbinafine and various treatment protocols, both patients demonstrated recovery followed by skin desquamation during the subsequent weeks. Terbinafine is the most frequently used systemic antimycotic and antifungal medication, reflecting its superior efficacy for dermatophyte infections. Despite the appealing drug profile, an awareness of terbinafine-induced AGEP is important given the 5 percent mortality associated with AGEP. Additionally, distinguishing the characteristics of AGEP from those associated with toxic epidermal necrolysis, Stevens-Johnson syndrome, and generalized pustular psoriasis allows for prompt dermatologic evaluation, accurate diagnosis, and appropriate treatment. (+info)Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome. (5/6)
(+info)Acute generalized exanthematous pustulosis due to dextromethorphan. (6/6)
Acute generalized exanthematous pustulosis (AGEP) is a rare, severe, pustular, cutaneous reaction. We report a case in which a patient developed AGEP after the intake of 3 different antitussive agents containing dextromethorphan as the only ingredient in common. (+info)
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Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum
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We are currently recruiting patients with Palmoplantar Pustulosis (PPP). This study investigates the Efficacy and safety of...
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Acute generalized exanthematous pustulosis
... (AGEP) (also known as pustular drug eruption and toxic pustuloderma) is a rare skin ... "Acute generalised exanthematous pustulosis , DermNet NZ". dermnetnz.org. Retrieved 2021-01-14. Lerch M, Mainetti C, Terziroli ... Halevy S (August 2009). "Acute generalized exanthematous pustulosis". Curr Opin Allergy Clin Immunol. 9 (4): 322-8. doi:10.1097 ... Szatkowski J, Schwartz RA (November 2015). "Acute generalized exanthematous pustulosis (AGEP): A review and update". Journal of ...
Drug reaction with eosinophilia and systemic symptoms
Feldmeyer L, Heidemeyer K, Yawalkar N (2016). "Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, ... and Acute generalized exanthematous pustulosis (AGEP). The SCARs disorders have similar disease mechanisms. New strategies are ... Lung involvement takes the form of interstitial pneumonitis, pleuritis, or the acute respiratory distress syndrome; minocycline ... acute tubular necrosis, or vasculitis and may lead to kidney failure and, uncommonly, be lethal. ...
Severe cutaneous adverse reactions
Feldmeyer L, Heidemeyer K, Yawalkar N (2016). "Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, ... and Acute generalized exanthematous pustulosis (AGEP). The five disorders have similar pathophysiologies, i.e. disease-causing ... "Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a ... particularly in the acute, early stage of these disorders. The drugs most commonly triggering the SJS, TEN, and SJS/TEN ...
Etoricoxib
Fixed drug eruption and generalised erythema, acute generalized exanthematous pustulosis (AGEP), erythema multiforme like ... Mäkelä L, Lammintausta K (2008). "Etoricoxib-induced acute generalized exanthematous pustulosis". Acta Dermato-Venereologica. ... A Cochrane review assessed the benefits of single-dose etoricoxib in reduction of acute post-operative pain in adults. Single- ... 1-2. Clarke R, Derry S, Moore RA (May 2014). "Single dose oral etoricoxib for acute postoperative pain in adults". The Cochrane ...
Nystatin
Rosenberger A, Tebbe B, Treudler R, Orfanos CE (June 1998). "[Acute generalized exanthematous pustulosis, induced by nystatin ... burning and acute generalized exanthematous pustulosis Like amphotericin B and natamycin, nystatin is an ionophore. It binds to ...
Tetrazepam
2008). "Acute generalized exanthematous pustulosis due to tetrazepam" (PDF). Journal of Investigational Allergology & Clinical ...
Stevens-Johnson syndrome
Feldmeyer L, Heidemeyer K, Yawalkar N (2016). "Acute Generalized Exanthematous Pustulosis: Pathogenesis, Genetic Background, ... acute generalized exanthematous pustulosis (AGEP) and toxic epidermal necrolysis in a group of conditions known severe ... drug reaction dependent in part on the tissue-injuring actions of eosinophils and acute generalized exanthematous pustulosis ... Surovik J, Riddel C, Chon SY; Riddel; Chon (2010). "A case of bupropion-induced Stevens-Johnson syndrome with acute psoriatic ...
Interleukin 36
In addition, in acute generalized exanthematous pustulosis, IL-36 (mainly IL-36 gamma) was overexpressed in skin lesions. ... "Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis". Journal of Investigative ...
Stasis papillomatosis
... is similar to AGEP (Acute generalized exanthematous pustulosis) from pustular psoriasis; criteria for ... The disease can be either localized or generalized; the localized form makes up 78% of cases. Treatment includes surgical and ...
Pustulosis
Acute generalized exanthematous pustulosis Pustulosis palmaris et plantaris "Definition of Pustulosis". Retrieved 2007-08-26. v ... Pustulosis is highly inflammatory skin condition resulting in large fluid-filled blister-like areas - pustules. Pustulosis ... The skin of these areas peels and flakes (exfoliates). This condition-also referred to as "palmo-plantar pustulosis"-is a ...
Interleukin 36 receptor antagonist
... and acute generalized exanthematous pustulosis (AGEP). GRCh38: Ensembl release 89: ENSG00000136695 - Ensembl, May 2017 GRCm38: ... "Rare variations in IL36RN in severe adverse drug reactions manifesting as acute generalized exanthematous pustulosis". The ... a decrease or production of defective IL-36RA protein have been shown to cause inflammatory skin diseases including generalised ...
Drug eruption
For example, Acute generalized exanthematous pustulosis usually occurs within 4 days of starting the culprit drug. Drug ... erythroderma and acute generalized exanthematous pustulosis (AGEP). These severe cutaneous drug eruptions are categorized as ... Simple exanthematous eruptions occur between 4 and 14 days after exposure. TEN and SJS are severe cutaneous drug reactions that ... Cohen PR (2007). "Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis". Orphanet J Rare Dis. 2 ...
Dolomiaea costus
... induced acute generalized exanthematous pustulosis confirmed by patch testing". Dermatologica Sinica. 37 (2): 98. doi:10.4103/ ...
Sulfonamide (medicine)
... acute generalized exanthematous pustulosis. Any one of these SCARs may be triggered by certain sulfonamides. Approximately 3% ... and acute pancreatitis, among others. Dihydropteroate synthase Elixir sulfanilamide Hellmuth Kleinsorge (1920-2001) German ...
Nonsteroidal anti-inflammatory drug
... acute generalized exanthematous pustulosis, the Stevens-Johnson syndrome, and toxic epidermal necrolysis. Other NSAID ... Interstitial nephritis Nephrotic syndrome Acute kidney injury Acute tubular necrosis Renal papillary necrosis NSAIDs in ... Bally M, Dendukuri N, Rich B, Nadeau L, Helin-Salmivaara A, Garbe E, Brophy JM (May 2017). "Risk of acute myocardial infarction ... 11 May 2022). "Acute inflammatory response via neutrophil activation protects against the development of chronic pain". Science ...
Toxic epidermal necrolysis
Drug-induced linear immunoglobulin A dermatosis Acute graft versus host disease Acute generalized exanthematous pustulosis ... Those who survive the acute phase of TEN often develop long-term complications affecting the skin and eyes. Skin manifestations ... Ability to draw more generalized conclusions from research to date has been limited by lack of controlled trials, and ... is a scoring system developed to assess the severity of TEN and predict mortality in patients with acute TEN. One point is ...
NSAID hypersensitivity reactions
... acute generalized exanthematous pustulosis, the Stevens-Johnson syndrome, and toxic epidermal necrolysis (also termed Lyell's ... NSAIDs-exacerbated cutaneous disease (NECD) is an acute exacerbation of wheals and/or angioedema in individuals with a history ... Single NSAID-induced urticarial/angioedema or anaphylaxis (SNIUAA) is the acute development of urticarial, angioedema, or ... is the acute development of wheals and/or angioedema in individuals with no history of chronic NSAIDs-induced urticaria or ...
Eslicarbazepine acetate
... are under increased risk of developing skin reactions such as acute generalized exanthematous pustulosis (AGEP), but also ... "Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from ...
AGEP
... is an acronym that may refer to: Acute generalized exanthematous pustulosis AGEP Association Management, a Belgium-based ...
List of skin conditions
Acrodynia (calomel disease, erythredemic polyneuropathy, pink disease) Acute generalized exanthematous pustulosis (pustular ... and Acute generalized exanthematous pustulosis) Scleroderma-like reaction to taxanes Serum sickness-like reaction Steroid acne ... acute guttate parapsoriasis, acute parapsoriasis, acute pityriasis lichenoides, Mucha-Habermann disease, parapsoriasis acuta, ... acute or chronic), arrangement (solitary, generalized, annular, linear), morphology (macules, papules, vesicles), and color ( ...
Republished: Concurrent terbinafine-induced acute generalised exanthematous pustulosis and hepatitis | Drug and Therapeutics...
Drug Eruptions Clinical Presentation: History, Physical Examination, Complications
Acute generalized exanthematous pustulosis (AGEP). Acute-onset fever and generalized scarlatiniform erythema occur with many ... Exanthematous eruptions in children are more likely to be due to a viral infection than another infection; however, most such ... Morbilliform or exanthematous. This is the most common pattern of drug eruptions; it is the quintessential drug rash. Exanthem ... Generalized fixed drug eruption to piperacillin/tazobactam and review of literature. Dermatol Online J. 2018 Apr 15. 24 (4):[ ...
IMSEAR at SEARO: Acute generalised exanthematous pustulosis.
acute generalized exanthematous pustulosis | Taber's Medical Dictionary
acute generalized exanthematous pustulosis answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. ... exanthematous_pustulosis. Acute generalized exanthematous pustulosis. In: Venes DD, ed. Tabers Medical Dictionary. F.A. Davis ... exanthematous_pustulosis. Acute Generalized Exanthematous Pustulosis [Internet]. In: Venes DD, editors. Tabers Medical ... exanthematous_pustulosis. Accessed November 29, 2022.. Acute generalized exanthematous pustulosis. (2021). In Venes, D. (Ed.), ...
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Acute Generalized Exanthematous Pustulosis Induced by Clindamycin | Dermatology | JAMA Dermatology | JAMA Network
Acute generalized exanthematous pustulosis (AGEP) involves numerous nonfollicular sterile pustular lesions associated with ... Acute Generalized Exanthematous Pustulosis Induced by Clindamycin. Roger Kapoor; Christina Flynn; Peter W. Heald, MD; et al ... Acute Generalized Exanthematous Pustulosis Induced by Clindamycin. Arch Dermatol. 2006;142(8):1065-1086. doi:10.1001/archderm. ... Acute generalized exanthematous pustulosis (AGEP) involves numerous nonfollicular sterile pustular lesions associated with ...
Search Results: Lateral neck, Rash or multiple lesions
IL36RN gene: MedlinePlus Genetics
The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized ... Like GPP (described above), acute generalized exanthematous pustulosis (AGEP), is characterized by a rash and pustules over a ... Generalized pustular psoriasis. More than a dozen IL36RN gene mutations have been found to increase susceptibility to a serious ... For example, palmoplantar pustulosis affects the hands and feet, and acrodermatitis continua of Hallopeau affects the tips of ...
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... acute generalized exanthematous pustulosis have been reported. (5.3) • Worsening of Psoriasis and Porphyria: Avoid in patients ... acute generalized exanthematous pustulosis (AGEP). Monitor for serious skin reactions, especially in patients receiving a drug ... acute generalized exanthematous pustulosis, Drug Rash with Eosinophilia and Systemic Symptoms (DRESS syndrome), Stevens-Johnson ... Signs and symptoms of cardiac compromise have occurred during acute and chronic PLAQUENIL treatment. In multiple cases, ...
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Erythroderma (Generalized Exfoliative Dermatitis) Clinical Presentation: History, Physical Examination, Complications
Eyler JT, Squires S, Fraga GR, Liu D, Kestenbaum T. Two cases of acute generalized exanthematous pustulosis related to oral ... Midodrine-induced acute generalized exanthematous pustulosis. Cutis. 2014 May. 93(5):E17-20. [QxMD MEDLINE Link]. ... encoded search term (Erythroderma (Generalized Exfoliative Dermatitis)) and Erythroderma (Generalized Exfoliative Dermatitis) ... Erythroderma (Generalized Exfoliative Dermatitis) Clinical Presentation. Updated: Oct 15, 2020 * Author: Sanusi H Umar, MD, ...
Omnipaque, Oraltag (iohexol) dosing, indications, interactions, adverse effects, and more
... acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS) ... Contrast induce acute kidney injury. *Acute kidney injury, including renal failure, may occur after parenteral administration; ... Focal and generalized motor seizures reported patients with history of epilepsy when higher than recommended doses used ... Acute renal failure reported in diabetic patients with diabetic nephropathy and in susceptible nondiabetic patients (often ...
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Acute generalised exanthematous pustulosis (acute febrile drug eruption): 170 reports. *Acute hepatic failure: 125 reports ... Acute myocardial infarction (acute heart attack): 1,171 reports. *Acute pulmonary oedema (sudden deposit of fluid in the lung)) ... Acute kidney failure: 7,985 reports. *Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts ... Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 358 reports ...
KoreaMed
Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis ... BACKGROUND: Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous ... Acute cholecystitis after a colonoscopy is a rare event, and only eight documented cases are reported in the literature. A 35- ... Acute Cholecystitis After a Colonoscopy Park TI, Lee SY, Lee JH, Kim MC, Kim BG, Cha DH ...
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... of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis ... of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis ... of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis ... of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis ...
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AGEPPustularPsoriasisEruptionPalmoplantar pustulosis2021DisordersSyndromeOtitis mediaErythemaClindamycinHepatitisPatientsDrugAcetaminophenSecondaryTreatmentAnaphylaxisHemolyticRashesAtypicalRenalEruptionsSevereTreatment of acute painReactionsBacterialPathophysiologyOverlapChronicPathogenesisSkinCoronaryPrevalent causeDiagnosisLiverDrugClinicalCaseTypeAbstractSearchManagement
AGEP11
- Acute generalised exanthernatous pustulosis (AGEP) is a condition characterised by sudden onset of non-follicular aseptic pustules all over the body. (who.int)
- Acute generalized exanthematous pustulosis (AGEP) involves numerous nonfollicular sterile pustular lesions associated with fever above 38°C, neutrophilic leukocytosis, an intensely pruritic rash, and in later stages, desquamation. (jamanetwork.com)
- Like GPP (described above), acute generalized exanthematous pustulosis (AGEP), is characterized by a rash and pustules over a large area of the body, typically triggered by antibiotics or other medications. (medlineplus.gov)
- The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis. (medlineplus.gov)
- BACKGROUND: Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). (koreamed.org)
- Another group of 13 PPIs was associated with potential acute generalized exanthematous pustulosis (AGEP). (qualitycounts.com)
- and other hypersensitivity reactions (fixed drug eruptions, DRESS, drug-induced hypersensitivity syndrome, symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], acute generalized exanthematous pustulosis [AGEP], and acute febrile neutrophilic dermatosis or Sweet Syndrome). (uspharmacist.com)
- While there are different names for different types of severe drug reactions, including Stevens-Johnson syndrome (SJS), drug rash with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP), they are often grouped together as severe cutaneous adverse reactions (SCARs). (harvard.edu)
- Acute generalized exanthematous pustulosis (AGEP) is a dermatological disease occurring in the aftermath of drug use. (aphp.fr)
- Objective We sought to investigate the molecular basis of 3 pustular skin disorders: generalized pustular psoriasis (GPP), palmoplantar pustulosis (PPP), and acute generalized exanthematous pustulosis (AGEP). (elsevier.com)
- Severe hypersensitivity reactions, including severe skin reactions such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalised exanthematous pustulosis (AGEP) have been reported in patients receiving clindamycin therapy. (medthority.com)
Pustular1
- More than a dozen IL36RN gene mutations have been found to increase susceptibility to a serious skin disorder called generalized pustular psoriasis (GPP). (medlineplus.gov)
Psoriasis10
- For adults with generalized plaque psoriasis, the recommended NB-UVB phototherapy starting dose should be based on the minimal erythema dose or it should be determined based on a fixed-dose or skin-phototype protocol. (medscape.com)
- For adults with generalized plaque psoriasis, a treatment phase of thrice-weekly dosing of NB-UVB phototherapy is recommended. (medscape.com)
- In adults with generalized plaque psoriasis, NB-UVB is recommended over broadband ultraviolet B (BB-UVB) monotherapy. (medscape.com)
- For appropriate patients with generalized plaque psoriasis, home-based NB-UVB phototherapy is recommended as an alternative to in-office NB-UVB phototherapy. (medscape.com)
- Treatment with NB-UVB phototherapy is recommended for pregnant patients who have guttate psoriasis or generalized plaque psoriasis. (medscape.com)
- Oral retinoids can be combined with NB-UVB phototherapy in appropriate patients with generalized plaque psoriasis if they have not responded adequately to monotherapy. (medscape.com)
- Owing to an increased risk of developing skin cancer, long-term combination therapy with NB-UVB and cyclosporine is not recommended for adults with generalized plaque psoriasis. (medscape.com)
- In adults with generalized plaque psoriasis, BB-UVB phototherapy is recommended as monotherapy if NB-UVB is not available. (medscape.com)
- In adults with generalized plaque psoriasis, BB-UVB monotherapy is considered less efficacious than NB-UVB or oral PUVA monotherapy. (medscape.com)
- Combination therapy with acitretin and BB-UVB can be considered in adults with generalized plaque psoriasis. (medscape.com)
Eruption3
- 200 cells/µL) have a 10- to 50-fold increased risk of developing an exanthematous eruption to sulfamethoxazole. (medscape.com)
- Rare skin eruption characterized by acute formation of pustules filled with NEUTROPHILS , fever, and peripheral blood LEUKOCYTOSIS . (bvsalud.org)
- Immune-histopathological features allow to distinguish generalized bullous drug eruption from SJS/TEN [ 3 - 6 ]. (biomedcentral.com)
Palmoplantar pustulosis1
- For example, palmoplantar pustulosis affects the hands and feet, and acrodermatitis continua of Hallopeau affects the tips of the fingers and toes. (medlineplus.gov)
20211
- 2021. https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/729160/all/acute_generalized_exanthematous_pustulosis. (unboundmedicine.com)
Disorders1
- A group of rare genetic hypopigmentation disorders characterized by a generalized reduction in pigmentation of hair, skin and eyes and variable ocular findings including nystagmus, reduced visual acuity and photophobia. (aphp.fr)
Syndrome1
- Stevens Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis have been reported. (nih.gov)
Otitis media1
- It is also used to treat ear infections (such as acute otitis media) and skin & soft tissue infections (such as an abscess or boil) in affected children which is also indicated for use to treat sexually transmitted diseases (caused by organisms such as chlamydia trachomatis/ Neisseria gonorrhoea) in the affected child. (netmeds.com)
Erythema2
- Acute-onset fever and generalized scarlatiniform erythema occur with many small, sterile, nonfollicular pustules. (medscape.com)
- Patients often present with generalized erythema. (medscape.com)
Clindamycin1
- Kapoor R, Flynn C, Heald PW, Kapoor JR. Acute Generalized Exanthematous Pustulosis Induced by Clindamycin. (jamanetwork.com)
Hepatitis1
- Our patient had concurrent acute generalised exanthematous pustulosis and hepatitis that together has been very rarely associated with terbinafine. (bmj.com)
Patients3
- 500 mg IV for acute lowering of IOP or in patients unable to take the oral dosage. (pdr.net)
- XARTEMIS XR is an oral medication indicated for the management of acute pain severe enough to require opioid treatment in patients for whom alternative treatment options (e.g., non-opioid analgesics) are ineffective, not tolerated or would otherwise be inadequate. (mallinckrodt.com)
- It is the first and only oxycodone HCI/acetaminophen combination for acute pain with immediate- and extended-release analgesia, providing fast-acting and long-lasting pain relief with 12-hour dosing for patients. (mallinckrodt.com)
Drug1
- Although most drug eruptions are exanthematous, different types of drug eruptions are described. (medscape.com)
Acetaminophen1
- Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. (prescriptiondrugs.com)
Secondary1
- For the treatment of secondary glaucoma and pre-operatively for acute angle-closure glaucoma. (pdr.net)
Treatment2
Anaphylaxis1
- The classic system of Gell and Coombs 1 ( Table 4 ) still provides a good basis for understanding drug hypersensitivity reactions, although the vast majority of reactions fall into either type 1 (acute IgE mediated: urticaria or anaphylaxis) or type 4 (cell mediated: delayed rash or organ pathology). (racgp.org.au)
Hemolytic1
- 13. Acute generalized exanthematous pustulosis and Coombs-positive hemolytic anemia in a child following Loxosceles reclusa envenomation. (nih.gov)
Rashes1
- Rashes due to antibiotics are most often morbilliform ( exanthematous ) or urticarial [1]. (dermnetnz.org)
Atypical1
- 6. Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation. (nih.gov)
Renal2
- Acute interstitial nephritis (AIN) is characterized by a sudden impairment of renal function, mild proteinuria, and sterile pyuria. (asnjournals.org)
- Dogs with subclinical renal dysfunction are Acute generalized exanthematous pustulosis is often more sensitive to the toxicity of gentamicin and caused by lactam and macrolide antibiotics >8]. (orionbilisim.net)
Eruptions3
- Pruritic generalized maculopapular erythematous eruptions were observed over the entire body. (nih.gov)
- Patients with generalized pustular psoriasis eruptions may require hospitalization to ensure adequate hydration, bed rest, and avoidance of excessive heat loss. (medscape.com)
- less frequently, acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms , systemic drug-related intertriginous and flexural exanthema, toxic epidermal necrolysis and fixed drug eruptions were present. (tulsaallergynews.com)
Severe3
- Generalized pustular psoriasis (GPP) is a rare severe variant of psoriasis that is characterized by the abrupt widespread onset of small pustules accompanied by systemic manifestations of inflammation. (bvsalud.org)
- SEGLENTIS contains tramadol hydrochloride, an opioid agonist, and celecoxib, a nonsteroidal anti-inflammatory drug, and is indicated for the management of acute pain in adults that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate. (seglentis.com)
- In patients receiving darunavir, a component of SYMTUZA ® , severe skin reactions may occur, including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis. (symtuzahcp.com)
Treatment of acute pain2
- CATRAMOL is indicated for short-term treatment of acute pain. (mims.com)
- The Phase 3 factorial study compared lower doses of the individual components of SEGLENTIS than are optimal for treatment of acute pain. (seglentis.com)
Reactions2
- Serious skin reactions , including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis can occur with this medicine. (mayoclinic.org)
- Patients who have experienced asthma, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria or other allergic-type reactions after taking acetylsalicylic acid (aspirin) or other NSAIDs including COX-2 (cyclooxygenase-2) inhibitors. (medthority.com)
Bacterial2
- System effects of Lioresal may be additive to those space between nerves and attach to receptors on the surface of nearby nerves disorders that is equally effective use, on generalized mild to help prevent bacterial infections like azithromycin reference guide for skin rash. (gradlesummit.com)
- Acute bacterial exacerbations of chronic obstructive pulmonary diseases caused by Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae . (pfizermedicalinformation.ca)
Pathophysiology1
- 14. Acute localized exanthematous pustulosis: Clinical features, pathophysiology, and therapy. (nih.gov)
Overlap1
- 3. Acute generalized exanthematous pustulosis and Stevens-Johnson syndrome overlap due to hydroxychloroquine: a case report. (nih.gov)
Chronic1
- With large acute doses or with chronic use, the major metabolic pathways-the glucuronide and sulfate conjugation systems-become saturated, and more acetaminophen is metabolized by the CYP450 system. (uspharmacist.com)
Pathogenesis2
- The study of IL35RN gene mutations in the pathogenesis of generalized pustular psoriasis has led to new advances in treatment. (medscape.com)
- Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP. (canadianpsoriasis.ca)
Skin1
- More than a dozen IL36RN gene mutations have been found to increase susceptibility to a serious skin disorder called generalized pustular psoriasis (GPP). (medlineplus.gov)
Coronary1
- Heparin use in acute coronary syndromes and cardiovascular interventions: habit or evidence based? (kingsthrombosiscentre.org.uk)
Prevalent cause2
- It has become the most common cause of acute liver failure and the second most prevalent cause of liver failure requiring transplantation. (uspharmacist.com)
- Acetaminophen is the most prevalent cause of acute liver failure in the United States, according to the Cleveland Clinic . (healthdigest.com)
Diagnosis1
- A definite diagnosis of acute exanthematous pustulosis was made based on the presence of most of the clinical and histologic criteria recently delineated: typical pustules in a typical distribution, acute onset and acute resolution, low-grade fever and neutrophilia, and representative subcorneal spongiform pustules. (medscape.com)
Liver3
- Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. (drugs.com)
- 5 However, hepatotoxicity is a common consequence of overconsumption, which can result in a range of problems, including abnormalities in liver function, acute liver failure, and even death. (uspharmacist.com)
- In fact, a 2017 study published in the Journal of Hepatology says that acetaminophen toxicity actually accounts for 46% of all acute liver failure in the United States. (healthdigest.com)
Drug3
- These findings point, without doubt, to paracetamol as the drug responsible for inducing acute generalized exanthematous pustulosis in this case. (medscape.com)
- Cheaply 50 of the acute was identified in the ozone as directed drug. (allayurveda.com)
- The European Medicines Agency's Pharmacovigilance Risk Assessment Committee advises ibuprofen manufacturers to add warnings on patient information leaflets concerning acute generalized exanthematous pustulosis associated with use of the drug. (informa.com)
Clinical1
- Clinical profile, morbidity, and outcome of adult-onset generalized pustular psoriasis: analysis of 102 cases seen in a tertiary hospital in Johor, Malaysia. (canadianpsoriasis.ca)
Case5
- This is a case report of a young girl who developed acute generalized exanthematous pustulosis following phenytoin therapy for post-traumatic seizures. (elsevier.com)
- 1. Acute generalized exanthematous pustulosis caused by gemcitabine after nivolumab in metastatic lung adenocarcinoma followed by a dramatic tumor response: A case report. (nih.gov)
- 2. A mild case of acute generalized exanthematous pustulosis caused by gemcitabine. (nih.gov)
- 9. Acute Generalized Exanthematous Pustulosis Induced by Amoxicillin/Clavulanic Acid: Report of a Case Presenting With Generalized Lymphadenopathy. (nih.gov)
- 12. Acute generalized exanthematous pustulosis induced by piroxicam: a case report. (nih.gov)
Type1
- Acute generalized pustular psoriasis, von Zumbusch type, treated in the burn unit. (canadianpsoriasis.ca)
Abstract1
- abstract = "Phenytoin is the first line antiepileptic for generalized tonic-clonic seizures. (elsevier.com)
Search1
- These images are a random sampling from a Bing search on the term "Acute Generalized Exanthematous Pustulosis. (fpnotebook.com)
Management1
- The Prescribing information section has been updated, and information on oral flucloxacillin and clarithromycin has been removed, as oral antibiotics are not routinely needed in primary care for the management of uncomplicated acute otitis externa, in line with current evidence in the literature. (medicinescomplete.com)