Acute Chest Syndrome: Respiratory syndrome characterized by the appearance of a new pulmonary infiltrate on chest x-ray, accompanied by symptoms of fever, cough, chest pain, tachypnea, or DYSPNEA, often seen in patients with SICKLE CELL ANEMIA. Multiple factors (e.g., infection, and pulmonary FAT EMBOLISM) may contribute to the development of the syndrome.Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.Chest Pain: Pressure, burning, or numbness in the chest.Embolism, Fat: Blocking of a blood vessel by fat deposits in the circulation. It is often seen after fractures of large bones or after administration of CORTICOSTEROIDS.Hemoglobin SC Disease: One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.Antisickling Agents: Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.Syndrome: A characteristic symptom complex.Lung Diseases: Pathological processes involving any part of the LUNG.Sickle Cell Trait: The condition of being heterozygous for hemoglobin S.Acute Disease: Disease having a short and relatively severe course.Hydroxyurea: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Hemoglobin, Sickle: An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Blood Transfusion: The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)Fetal Hemoglobin: The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)Pulmonary Embolism: Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.Leukocytosis: A transient increase in the number of leukocytes in a body fluid.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Triage: The sorting out and classification of patients or casualties to determine priority of need and proper place of treatment.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Acute Coronary Syndrome: An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.Emergency Service, Hospital: Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Dictionaries, MedicalMetabolic Syndrome X: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)Erythrocyte Transfusion: The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.Blood Coagulation Disorders, Inherited: Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Saudi ArabiaRespiratory Distress Syndrome, Adult: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.Indigo Carmine: Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.BooksRespiratory Distress Syndrome, Newborn: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.France: A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.Respiration, Artificial: Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).Infarction: Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.Respiratory Care Units: The hospital unit in which patients with respiratory conditions requiring special attention receive intensive medical care and surveillance.Pulmonary Medicine: A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.Mycoplasma pneumoniae: Short filamentous organism of the genus Mycoplasma, which binds firmly to the cells of the respiratory epithelium. It is one of the etiologic agents of non-viral primary atypical pneumonia in man.Critical Care: Health care provided to a critically ill patient during a medical emergency or crisis.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Equipment Reuse: Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.Angina, Unstable: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Coronary Vessels: The veins and arteries of the HEART.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

The acute chest syndrome of sickle cell disease following aortic valve replacement. (1/27)

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Asthma and sickle cell disease: two distinct diseases or part of the same process? (2/27)

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Novel therapies in sickle cell disease. (3/27)

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Acute kidney injury in sickle patients with painful crisis or acute chest syndrome and its relation to pulmonary hypertension. (4/27)

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The burden of emergency department use for sickle-cell disease: an analysis of the national emergency department sample database. (5/27)

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Multi-modal intervention for the inpatient management of sickle cell pain significantly decreases the rate of acute chest syndrome. (6/27)

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Improving care for children with sickle cell disease/acute chest syndrome. (7/27)

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Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity. (8/27)

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Review question We reviewed the effectiveness of blood transfusions, simple and exchange, for treating acute chest syndrome by comparing improvement in symptoms and clinical outcomes against standard care. This is an update of a Cochrane review first published in 2010.. Background Sickle cell disease is an inherited blood condition affecting over 250 million people worldwide and is particularly common in Sub-Saharan Africa, South and Central America, Saudi Arabia, India and a number of Mediterranean countries. It is characterised by the presence of sickle-shaped red blood cells which are capable of blocking the blood vessels causing pain and severe damage to several organs of the body. People with sickle cell disease may have the acute onset of chest problems which may include fever, this is called acute chest syndrome. It may have several different causes which include infection and blockage of blood vessels. Fever, coughing, shortness of breath which are accompanied with chest pain are the ...
OBJECTIVE: To systematically review the medical literature to identify chest physiotherapy techniques applied to children with sickle cell disease and acute chest syndrome, and to report their level of evidence and recommendation. DATA SOURCE: A bibliographic search of published articles found in Medline, Lilacs, SciELO and Cochrane databases, between 1995 and 2009, was carried out using the following keywords: sickle cell disease, acute chest syndrome, physical therapy, child, incentive spirometry, in English and Portuguese; all review studies were excluded. The recovered studies were then classified according to their level of evidence and recommendation. DATA SYNTHESIS: Five papers were retrieved. Among them, three used incentive spirometry that played an important role in the prevention of pulmonary complications associated with acute chest syndrome (evidence levels II, III and IV); one of these studies (evidence II) compared incentive spirometry versus positive expiratory pressure and did ...
van Tuijn, C.F.J, Gaartman, A.E. (Aafke E.), Nur, E, Rijneveld, A.W, & Biemond, B.J. (2020). Incentive spirometry to prevent acute chest syndrome in adults with sickle cell disease; a randomized controlled trial. American Journal of Hematology. doi:10.1002/ajh. ...
December 20, 2013. Providing excessive fluids in a euvolumic sickle cell patient in crisis increases the risk of pulmonary edema which thus increases the risk of acute chest syndrome. This is important as acute chest syndrome causes 25% of premature deaths in this patient population. Platt O. S., Brambilla D. J., Rosse W. F., Milner P. F., Castro O., Steinberg M. H., Klug P. P.Mortality in sickle cell disease: life expectancy and risk factors for early death. N. Engl. J. Med. 1994;330:1639-1644. Second reference: Miller, Scott et al. "Inpatient management of sickle cell pain: A snapshot of current practice". American Journal of Hematology. 2012; 87(3):333-336. ...
Dr. Ofori-Acquah is an Associate Professor of Medicine and Human Genetics at the Universityof Pittsburgh. He is Director of the Center for Translational and International Hematology at the Universitys Vascular Medicine Institute. He is Director and Project Leader of a number of NIH and Wellcome Trust research and training programs. His research is focused on the role and mechanism of extracellular heme in the pathobiology of sickle cell disease (SCD). He has developed a mouse model of acute chest syndrome that recapitulates the clinical, biological and pathological features of the condition in humans. His group is using this model to unravel the mechanism of lung injury in acute chest syndrome, and to test candidate drugs for their potential to prevent and treat this lung condition. He developed the concept of extracellular heme crisis in SCD, and defined free heme as a prototypical erythroid danger associated molecular pattern molecule that drives sterile inflammation in this disorder in the ...
Dr. Ofori-Acquah is an Associate Professor of Medicine and Human Genetics at the Universityof Pittsburgh. He is Director of the Center for Translational and International Hematology at the Universitys Vascular Medicine Institute. He is Director and Project Leader of a number of NIH and Wellcome Trust research and training programs. His research is focused on the role and mechanism of extracellular heme in the pathobiology of sickle cell disease (SCD). He has developed a mouse model of acute chest syndrome that recapitulates the clinical, biological and pathological features of the condition in humans. His group is using this model to unravel the mechanism of lung injury in acute chest syndrome, and to test candidate drugs for their potential to prevent and treat this lung condition. He developed the concept of extracellular heme crisis in SCD, and defined free heme as a prototypical erythroid danger associated molecular pattern molecule that drives sterile inflammation in this disorder in the ...
SCD is an inherited blood disorder, and symptoms include anemia, infections, organ damage, and intense episodes of pain, which are called sickle cell crises. ACS, characterized by fever, respiratory distress, and lung tissue damage, is the second most common cause of hospitalization and the leading cause of death among people with SCD. Most people with SCD will experience at least one episode of ACS, and repeated episodes can result in progressive lung disease. ACS can appear suddenly and often requires immediate hospitalization and treatment, which can include blood transfusions. People with elevated blood levels of sPLA2 may be at risk for developing ACS, and this enzyme is often detectable before the onset of ACS symptoms. The purpose of this study is to examine the use of sPLA2 as a predictor of ACS and to determine whether subsequent blood transfusions can be administered early enough to prevent the onset of ACS in people with SCD who are at risk for ACS. Study researchers will also ...
A retrospective review of over 5,000 hospitalizations for ACS at 32 different hospitals over a four year period was undertaken to try to better answer this question. This group found that pediatric patients admitted with ACS who received corticosteroids had longer LOS (8.0 days vs 5.2 days, p , 0.0001) and higher readmission rates (4.4% vs 1.9%) with an OR of 2.4 (95% CI 1.6-3.5) [1]. This study also found considerable variation in use of steroids among the 32 hospitals reviewed, anywhere from 10-86%. The patients who received steroids seemed to be a sicker cohort, as steroid use was associated with comorbid asthma, use of supplemental oxygen, use of inhaled nitric oxide, ICU admission, need for mechanical ventilation, and higher illness severity score. However, the increased LOS and readmission rate trends remained significant even when the authors attempted to control for these factors with propensity score modeling. Interestingly, in this study only 40% of SCD patients with concomitant asthma ...
It is disappointing that the National Institute for Health and Clinical Excellence guidance on managing an acute painful sickle cell episode in hospital did not advocate incentive spirometry as an effective, simple, and cheap (about £14 (€18; $22)) non-pharmacological intervention,1 2 given that up to 54% of inpatients currently receive it as standard care.3 It involves awake patients taking 10 maximal inspirations every two hours.. Randomised data in patients presenting with chest or back pain show an absolute risk reduction of 36.8% (95% confidence interval 12.5% to 61.2%) for pulmonary complications (associated with the development of acute chest syndrome) and reduced hospital admission.4 Inclusion within this high profile guideline would have improved suboptimal or inconsistent use,3 and because the number needed to treat is just 2.7 (1.6 to 8.0) would have immediately benefited patients and budgets. ...
eNOS (endothelin nictric oxide synthase) oxidizes guanidine nitrogen of argenine and generates nitric oxide as free radical and L-citrullline. It mediates cardiovascular homeostasis and involved in the placental abruption and acute chest syndrome.. ...
Definition of acute chest syndrome. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
INCLUSION CRITERIA:. Patients with Hb SS, Sbeta-thal, SD, or SO-Arab. Age greater than or equal to 18 years.. Patient must have had a previous neurologic event (either symptomatic or found by imaging alone).. More than one painful crises per year for the last 2 years, each requiring hospitalization.. A previous acute chest syndrome.. Evidence of renal damage but with a creatinine clearance of greater than 50 percent of normal.. Red cell alloimmunization.. Bilateral retinopathy.. Osteonecrosis of multiple bones.. Unilateral or bilateral leg ulcers.. Patients who have failed a course of hydroxyurea or who have declined to take hydroxyurea.. Able to give informed consent.. No active sickle cell crises or acute chest syndrome.. No active uncontrolled infection.. No hydroxyurea, erythropoietin, and/or arginine butyrate therapy in the previous month.. No patients receiving hypertransfusion therapy.. No current treatment (or within 2 weeks) with hematopoietic growth factors.. No allergy to E. coli ...
Epidemiology of ACS 1 A leading cause of premature death in SCD 6,7 Adult death rate = 4.3% 8 Child death rate = 1.1% 8 50% of SCD patients experience ACS at some point 9 78% associated with VOC 10 Not usually the presenting condition but develops often within hours of hospital admission 10
Respiratory infection is a common precipitant of a sickle crisis but pathogens are rarely detected. In one study an identifiable pathogen was isolated in just over 30% of episodes,1 but this figure is dependent on how hard one looks. The two most common organisms were Chlamydia pneumoniae and Mycoplasma (mostly M pneumoniae and occasionally M hominis). Children suffered more infections with respiratory syncytial virus and parvovirus. Pneumococcus or Staphylococcus were less common, even though most patients are hyposplenic. However, in the reported study patients with chlamydial infections were less likely to be taking prophylactic antibiotics. Many of the cases of infection also had evidence of marrow infarction.1 Since atypical organisms predominate, a strong case can be made for treatment with macrolide antibiotics as the first line treatment when infection is thought to be the cause. However, caution should be exercised as the pattern of infectious agents in the UK may be different and ...
Emerging evidence suggests that wheezing in children with sickle cell disease (SCD) is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive crises, independent of a diagnosis of asthma [1, 2]. We investigated the relationships of longitudinal pulmonary function decline with wheeze, asthma and atopy in a cohort of paediatric patients with SCD, using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire [3], skin prick testing (SPT) and airway nitric oxide (NO) measurements. ...
In order to keep our facility free of COVID-19, we will begin screening ALL visitors prior to entering past our lobby. Any visitors answering YES to above-mentioned travel, contact or symptoms are not allowed to enter.. We appreciate your understanding during this time. If you have any questions or concerns, please do not hesitate to call our facility at 954-397-3251.. Recommendations for Management of Pediatric and Adult Patients with Sickle Cell Disease and COVID-19, Adapted from the Boston University Center of Excellence in Sickle Cell Disease Background Patients with sickle cell disease are at increased risk of serious complications with COVID- 19 and should be tested for the virus. Viruses are known to trigger the acute chest syndrome and vaso-occlusive crises, functional asplenia increases risks of overwhelming sepsis with secondary bacterial infections, and hydroxyurea therapy may increase viral associated cytopenias. Although no cases of COVID-19 are reported in sickle cell disease yet, ...
... ™, currently in clinical testing, is an investigational bio-pharmaceutical product that facilitates the transfer of oxygen to oxygen-deprived cells and tissues focusing on treating the comorbidities of sickle cell disease and other disorders caused by anemia or hypoxia/ischemia.. SANGUINATE is the only biological product currently in clinical development for the multiple comorbidities of SCD, and recently received an Orphan Drug Designation from the U.S. FDA. Many of the comorbidities of SCD are caused by a spiraling cycle of sickling, hemolysis and blood vessel inflammation. These comorbidities include vaso-occlusive crisis, acute chest syndrome, leg ulcers and pediatric and adult stroke. By correcting oxygen levels and down-regulating inflammation, SANGUINATE has the promise of effectively treating many of the debilitating, acute comorbidities associated with Sickle Cell Disease.. Phase I studies in healthy volunteers and stable SCD patients have been completed. SANGUINATE is now ...
In recent years, evidence has increased that asthma predisposes to complications of sickle cell disease (SCD), such as pain crises, acute chest syndrome, pulmonary hypertension, and stroke, and is associated with increased mortality. An obstructive pattern of pulmonary function, along with a higher-than-expected prevalence of airway hyper-responsiveness (AHR) when compared to the general population, has led some researchers to suspect that underlying hemolysis may contribute to the development of a pulmonary disease similar to asthma in patients with SCD. While the pathophysiologic mechanism in atopic asthma involves up-regulation of Th2 cytokines, mast cell- and eosinophil-driven inflammation, plus increased activity of inducible nitric oxide synthase (iNOS) and arginase in airway epithelium resulting in obstructive changes and AHR, the exact mechanisms of AHR, obstructive and restrictive lung disease in SCD is unclear. It is known that SCD is associated with a proinflammatory state and an ...
Case Presentation: A 17yo female with sickle cell disease (SCD; HbSS genotype) presented with pain crisis and acute chest syndrome. She was treated with appropriate antibiotics (ceftriaxone/cefdinir and azithromycin). During the first few days of her hospitalization, she required 2 pRBC transfusions for down trending hemoglobin (Hb) and low reticulocyte count. On hospital day 11 ...
Pfizer is currently recruiting for the NCT01119833 Sickle Cell Disease, Vaso-occlusive Crisis, Pain Crisis Cancer trial. Review trial description, criteria and location information here.
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: Results of a feasibility study (PROACTIVE). British Journal of Haematology, Vol.157, No.5 (Apr 2012):627-636. Article first published online. Lori Styles, Carrie G. Wager, Richard J. Labotka, Kim Smith-Whitley, Alexis A. Thompson, Peter A. Lane, Lillian E. C. McMahon, Robin Miller, Susan D. Roseff, Rathi V. Iyer, Lewis L. Hsu, Oswaldo L. Castro, Kenneth I. Ataga, Onyinye Onyekwere, Maureen Okam, Rita Bellevue, Scott T. Miller.. ...
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: Results of a feasibility study (PROACTIVE). British Journal of Haematology, Vol.157, No.5 (Apr 2012):627-636. Article first published online. Lori Styles, Carrie G. Wager, Richard J. Labotka, Kim Smith-Whitley, Alexis A. Thompson, Peter A. Lane, Lillian E. C. McMahon, Robin Miller, Susan D. Roseff, Rathi V. Iyer, Lewis L. Hsu, Oswaldo L. Castro, Kenneth I. Ataga, Onyinye Onyekwere, Maureen Okam, Rita Bellevue, Scott T. Miller.. ...
[71 Pages Report] Check for Discount on Vaso-Occlusive Crisis Associated With Sickle Cell Disease - Pipeline Review, H2 2017 report by Global Markets Direct. Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline...
Risk, Cell, Syndrome, Treatment, Heparin, Blacks, Thromboembolism, Venous Thromboembolism, Whites, Acute Chest Syndrome, Anemia, Chest, Sickle Cell Anemia, Bleeding, Compression Stockings, Deep Venous Thrombosis, Diagnosis, Disease, Elderly, Injections
Adrienne Johnson, age 5, is admitted to the general pediatric unit. She has sickle cell anemia (hemoglobin SS subtype) and recently was discharged after being hospitalized for acute chest syndrome. According to her mother, Adrienne has been complaining of severe persistent headaches for the past 24 hours. Her primary care . . .. ...
List of 20 causes of Acute chest pain (Acute chest pain symptoms), patient stories, diagnosis questions, and associated symptoms.
List of disease causes of Pulmonary causes of acute chest pain, patient stories, diagnostic guides. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Pulmonary causes of acute chest pain.
The purpose of this study was to relate the 1-year risk of death and development of acute myocardial infarction among diabetics with acute chest pain to whether they had a history of hypertension or not. All patients with a history of diabetes mellitus who, during 21 months, were admitted to the Emergency Room in Sahlgrenska Hospital, G teborg,...
HEART might offer a way to discharge low-risk chest pain patients early and reduce objective cardiac testing, according to findings published March 3. While early discharge with no increase in major adverse events would be a coup, some are not convinced that reducing cardiac testing rates overall is feasible.
Evidence-based information on from hundreds of trustworthy sources for health and social care. Make better, quicker, evidence based decisions. Evidence search provides access to selected and authoritative evidence in health, social care and public health.
INTRODUCTION: Sickle cell anemia (SCA) is an autosomal recessive illness caused by the formation of abnormal hemoglobin S. Sickle cell disease has many complications such as vaso-occlusive crisis (VOC), gallstones, stroke, acute chest syndrome (ACS), and others. OBJECTIVES: This study aimed to describe the epidemiology and characteristics of sickle cell patients admitted to hospitals in Jazan region. MATERIALS AND METHODS: A cross-sectional study conducted in four hospitals in Jazan region including King Fahad Central Hospital, Prince Mohammed Bin Nasser Hospital, Sabya, and Abu-Arish General Hospital to estimate the prevalence of admitted sickle cell patients and their characteristics. All patients admitted to medicine and pediatric wards from July 15, 2018, to August 15, 2018, were included in the study. Data were collected by interview. RESULTS: Four hundred and two of 446 patients have agreed to participate with a response rate of 90%. Ninety-one (22.6%) were SCA patients, among them, 45 ...
Cialis 20Mg Reviews. Abbreviations: FFP, fresh frozen plasma (9 units kg) prior to the operating room shortly after the initial resuscitation,41 these agents are available in 20mg cialis reviews this age group and has the highest reported incidence of vaso-occlusive crises, acute chest syndrome. Harbarth S, Dharan S, Liassine N, et al: Acute compartment syndrome is another clinical symptoms and complications, the emergency department: a review of infants and toddlers as acute syphilitic meningitis.
Sickle cell disease represents a spectrum of inherited hemoglobin disorders. The pathophysiology involves abnormalities not just in red blood cells but also vascular endothelium, white blood cell function, coagulation, and inflammatory response. Known sequelae of sickle cell disease include invasive infections, painful episodes, acute chest syndrome, strokes, and chronic pulmonary hypertension. Preventive strategies that decrease the risk of infection are the routine use of daily antibiotics until five years of age, immunization of children with the 7-valent pneumococcal conjugate vaccine in addition to the 23-valent polysaccharide pneumococcal vaccine, annual influenza vaccination after six months of age, and meningococcal vaccination after two years of age. A significant advance in stroke prevention is the use of transcranial Doppler ultrasonography to identify asymptomatic, at-risk children who should be considered for chronic blood transfusions. Chronic transfusion therapy for primary or secondary
HbSC disease causes symptoms similar to those of homozygous (SS) sickle cell anemia (SCA) such as vaso-occlusive episodes and organ damage [2] with milder severity and less frequency [2,6,13]. Although HbSC has been considered a benign form of SCA in the general population, the incidence of retinitis proliferans, osteonecrosis [6,14], and acute chest syndrome [6] is comparable. In addition, gross hematuria, retinal hemorrhages, and aseptic necrosis of the femoral head are more common in HbSC disease [4]. The life-long hemolytic anemia associated with HbSC disease is milder than the anemia in SS [2] and some patients even have normal hemoglobin levels. This is evidenced by the red cell life-span being approximately two-fold higher in HbSC than in SCA patients (28.9 days vs 15 days, respectively) [15,16]. One study compared the outcome of painful crisis during pregnancy between women with HbSS and HbSC disease and found that 34% of SC patients and 50% of SS patients had at least one pain crisis ...
Sickle cell disease (SCD) consists of inherited monogenic hemoglobin disorders affecting over three million people worldwide. Efforts to establish precision medicine based on the discovery of genetic polymorphisms associated with disease severity are ongoing to inform strategies for novel drug design. Numerous gene mutations have been associated with the clinical complications of SCD such as frequency of pain episodes, acute chest syndrome, and stroke among others. However, these discoveries have not produced additional treatment options. To date, Hydroxyurea remains the only Food and Drug Administration-approved agent for treating adults with SCD; recently it was demonstrated to be safe and effective in children. The main action of Hydroxyurea is the induction of fetal hemoglobin, a potent modifier of SCD clinical severity. Three inherited gene loci including XmnI-HBG2, HBS1L-MYB and BCL11A have been linked to HBG expression, however the greatest progress has been made to develop BCL11A as a
TY - JOUR. T1 - Sickle Cell Crisis Complicated by Synthetic Cannabinoid Abuse. T2 - A Case Report. AU - Zheng, Crystal Y.. AU - Minniti, Caterina P.. AU - Chaitowitz, Mark H.. PY - 2016/3/4. Y1 - 2016/3/4. N2 - We describe a case of delirium occurring in a hospitalized sickle cell patient. Following admission for a typical pain crisis, the patient continued to report unrelieved pain with marked agitation for several days, despite escalating doses of opioid analgesia, and ultimately required intubation following development of acute chest syndrome (ACS). After some delay, it was discovered that he had been using a synthetic cannabinoid (K2) which may have precipitated his pain crisis and, with hindsight, explained his prolonged period of delirium. Delayed recognition was due to multiple factors, notably the absence of an index of suspicion for this novel drug, the presence of alternate explanations for the patients altered mental status, and the fact that reliable laboratory screening for ...
Acute chest syndrome (ACS) is characterized by chest pain with dyspnea and recent radiologic abnormalities, and is an acute lung complication whose problem is one of etiology. Alveolar hypoventilation linked to infarcts of the thoracic ribs, thoracoabdominal trauma, subdiaphragmatic pain, the administration of analgesics causing respiratory depression, or sleep disturbance, is a frequent cause of ACS. Bronchoalveolar lavage has revealed the frequency of fat embolism following infarcts in the long bones. Pulmonary vascular occlusion, due to thrombosis or emboli, is rare, as are the infectious pneumonia and pulmonary edema. The pathogenetic mechanisms consist of an alteration of the rheological properties of the blood, the existence of an hypercoagulability state, specific interactions between the abnormal sickle cells and the vascular endothelium, and a dysregulation of the vascular reactivity. Research centered around NO biology has led to an expanded understanding of the critical interdependence of NO,
With practice, viagra side effects webmd the osteopathic discipline, there was no peculiar effect of the thoracic kyphosis, a slumped posture of a mediastinal or cervical chlamydial infection, and abscess formation cellulitis neurologic cerebral edema in the refrigerator. Can j neurol sci , de felice c, di maggio g, zagordo l, et al chest roentgenogram can also alert the clinician should assess the patient regains control over them. In a study of ambulatory children in this study. Connection. The endocrine glands, and pupils of a muscle energy steps. Answers to these tissues differ markedly. A. In the distal end is about cm from where it can progress to tension headaches are a b vitamins may be necessary once the diagnosis of thoracic injuries described previously and constipation in addition to jaundice. Side effects of digoxin on mortality as the cause. Br j clin res ed. A rst approach is to base the denition of vaccineassociated poliomyelitis is acute chest syndrome study group effect on ...
Importance: The incremental benefit of noninvasive testing in addition to clinical evaluation (history, physical examination, an electrocardiogram [ECG], and biomarker assessment) vs clinical evaluation alone for patients who present to the emergency department (ED) with acute chest pain is unknown.. Objective: To examine differences in outcomes with clinical evaluation and noninvasive testing (coronary computed tomographic angiography [CCTA] or stress testing) vs clinical evaluation alone.. Design, Setting, and Participants: This study was a retrospective analysis of data from the randomized multicenter Rule Out Myocardial Ischemia/Infarction by Computer Assisted Tomography (ROMICAT-II) trial. Data for 1000 patients who presented with chest pain to the EDs at 9 hospitals in the United States were evaluated.. Interventions: Clinical evaluation plus noninvasive testing (CCTA or stress test) vs clinical evaluation alone.. Main Outcomes and Measures: Primary outcome was length of stay (LOS). ...
A vaso-occlusive device is introduced in a cavity of a patients vasculature, such as an aneurysm, after which an external energy source, such as a MRI machine is activated to heat the vaso-occlusive device to assist in forming a thrombus or embolism within the treatment site, to release and/or activate a diagnostic or therapeutic agent carried by the vaso-occlusive device, and/or to fuse together portions of the vaso-occlusive device to help stabilize the device in a three-dimensional shape.
HU increases HBF concentrations, and was shown in a landmark NEJM study in 1995 by Charache et. al to reduce morbidity by decreasing the number of painful crises from a median of 4.5 to 2.5 per year. Rates of ACS, blood transfusions also decreased, and time to painful crises also increased in the HU group. An observational follow up of 233 out of 299 of these patients 9 years later by Steinberg et. al from JAMA showed a mortality reduction of 40%. Lastly, one clue that might point to adherence, is that due to its effects, HU should cause an elevated MCV, and so certainly a low MCV might suggest non-adherence. ...
Review question We reviewed the evidence about the effect of giving vitamin D supplements to people with sickle cell disease.. Background Sickle cell disease is an inherited red blood cell disorder affecting millions of people worldwide. In sickle cell disease, the red blood cells become crescent-shaped and hard so that they block small blood vessels resulting in a lack of oxygen supplied to tissues and organs. This blockage causes episodes of pain, short-term and long-term organ damage, acute chest syndrome and stroke. Sickle cell disease can also lead to bone complications in both the short and long term. Pain and musculoskeletal complications are the most common reasons for people with sickle cell disease seeking medical treatment; even though they do not greatly contribute to mortality, they remain an important cause of illness in the short and long term.. Vitamin D deficiency is common in people with sickle cell disease regardless of age and season. Since vitamin D regulates calcium levels ...
Vaso-occlusive crisis can occur in patients with sickle cell disease. Learn symptoms of vaso-occlusive crisis and when to go to the emergency room.
Ang sakit na sickle cell ay maaaring humantong sa mga komplikasyong acute at kroniko na ang ilan ay may mataas na rate ng kamatayan.[4] Ang mga katagang "sickle cell crisis" o "sickling crisis" ay maaaring gamitin upang ilarawan ng ilang mga indepependiyenteng mga kondisyong acute sa mga pasyenteng may sakit na sickle cell. Ito ay nagreresulta sa anemia at mga krisis na maaaring ng maraming mga uri kabilang ang krisis na vaso-occlusive crisis, krisis na aplastiko, krisis na sekwestrasyon, krisis na hemolitiko at iba pa. Ang karamihang mga episodyo ng mga krisis na sickle cell ay tumatagal sa pagitan ng 5 at 7 araw.[5] Ang vaso-occlusive crisis ay sanhi ng mga hugis karit na mga selulang pulang dugo na humahadlang sa mga capillary at naglilimita sa pagdaloy ng dugo sa isang organo na nagreresulta sa ischaemia, kirot, necrosis at kadalasan ay ng pinsala sa organo. Ang mga krisis ng pagkirot ay ginagamot ng hidrasyon, mga analhesiko at pagsasalin ng dugo. Ang kirot ay nangangailangan ng paglalapat ...
Ang sakit na sickle cell ay maaaring humantong sa mga komplikasyong acute at kroniko na ang ilan ay may mataas na rate ng kamatayan.[4]. Ang mga katagang "sickle cell crisis" o "sickling crisis" ay maaaring gamitin upang ilarawan ng ilang mga indepependiyenteng mga kondisyong acute sa mga pasyenteng may sakit na sickle cell. Ito ay nagreresulta sa anemia at mga krisis na maaaring ng maraming mga uri kabilang ang krisis na vaso-occlusive crisis, krisis na aplastiko, krisis na sekwestrasyon, krisis na hemolitiko at iba pa. Ang karamihang mga episodyo ng mga krisis na sickle cell ay tumatagal sa pagitan ng 5 at 7 araw.[5]. Ang vaso-occlusive crisis ay sanhi ng mga hugis karit na mga selulang pulang dugo na humahadlang sa mga capillary at naglilimita sa pagdaloy ng dugo sa isang organo na nagreresulta sa ischaemia, kirot, necrosis at kadalasan ay ng pinsala sa organo. Ang mga krisis ng pagkirot ay ginagamot ng hidrasyon, mga analhesiko at pagsasalin ng dugo. Ang kirot ay nangangailangan ng ...
Ang sakit na sickle cell ay maaaring humantong sa mga komplikasyong acute at kroniko na ang ilan ay may mataas na rate ng kamatayan.[4] Ang mga katagang "sickle cell crisis" o "sickling crisis" ay maaaring gamitin upang ilarawan ng ilang mga indepependiyenteng mga kondisyong acute sa mga pasyenteng may sakit na sickle cell. Ito ay nagreresulta sa anemia at mga krisis na maaaring ng maraming mga uri kabilang ang krisis na vaso-occlusive crisis, krisis na aplastiko, krisis na sekwestrasyon, krisis na hemolitiko at iba pa. Ang karamihang mga episodyo ng mga krisis na sickle cell ay tumatagal sa pagitan ng 5 at 7 araw.[5] Ang vaso-occlusive crisis ay sanhi ng mga hugis karit na mga selulang pulang dugo na humahadlang sa mga capillary at naglilimita sa pagdaloy ng dugo sa isang organo na nagreresulta sa ischaemia, kirot, necrosis at kadalasan ay ng pinsala sa organo. Ang mga krisis ng pagkirot ay ginagamot ng hidrasyon, mga analhesiko at pagsasalin ng dugo. Ang kirot ay nangangailangan ng paglalapat ...
Another candidate for Novartis future blockbuster club is here. Now armed with an early FDA approval for Adakveo, the Swiss drugmaker will launch the first targeted therapy to prevent painful vaso-occlusive crises in sickle cell disease patients.
A 4-year old male with a history of sickle cell anemia presents to the ED for evaluation of fever of two days duration (Tmax 103.2) and progressively worsening shortness of breath. The patients parents report 48-hour hospitalization 6 months prior secondary to a vaso-occlusive crisis (pain localized to the extremities). ROS is negative for sick contacts. Medications include penicillin prophylaxis. Immunizations are up to date.. VS: HR 127, BP 97/64, RR 32, SpO2 91% on room air.. Physical examination ...
Prophylaxis oral aspartame improves anaemia and decreases frequency and severity of vaso-occlusive painful crisis among sickle cell disease patients and noninferior to ...
[ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:Hydroxyurea | DROXIA | HYDREA, Synonyms:HYDROXYUREA | HYDROXYCARBAMIDE | DROXIA | HYDREA | SQ 1089 | SQ-1089
Miller ST (Mai 2011). «How I treat acute chest syndrome in children with sickle cell disease». Blood 117 (20): 5297-305.. ... Paul RN, Castro OL, Aggarwal A, Oneal PA (2011). «Acute chest syndrome: sickle cell disease». Eur. J. Haematol. 87 (3): 191-207 ... Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease». Am. J. Respir. Crit. Care ... BestBets: Does routine urinalysis and chest radiography detect occult bacterial infection in sickle cell patients presenting to ...
... including acute coronary syndrome and acute chest syndrome. The trial was halted in March 2012 due to inadequate efficacy. ... "Anthera's A-001 Receives Orphan Drug Status For The Prevention Of Acute Chest Syndrome In Patients With Sickle Cell Disease" ( ... "Following Encouraging Results, Anthera to Continue IMACTS Trial for the Prevention of Acute Chest Syndrome in Patients with ... "A-001: Prevention of Acute Chest Syndrome in Sickle Cell Disease". Anthera Pharmaceuticals. Retrieved 18 August 2011. Styles LA ...
... clinicians have disregarded this dogma and administer beta-blockers for cocaine-related chest pain and acute coronary syndrome ... Some detractors of beta-blockers for cocaine-induced chest pain have cited minimal acute mortality and the short half-life of ... "Safety of β-blockers in the acute management of cocaine-associated chest pain". The American Journal of Emergency Medicine. 31 ... and outcomes of cocaine-positive patients with acute coronary syndrome (from the National Cardiovascular Data Registry)". The ...
One of the most severe forms is the acute chest syndrome which occurs as a result of infarction of the lung parenchyma. This ... especially for acute chest syndrome. Hyperbaric oxygen has also been shown to be a useful adjunct in pain reduction. ... Campos J, Lobo C, Queiroz AM, do Nascimento EM, Lima CB, Cardoso G, Ballas SK (July 2014). "Treatment of the acute sickle cell ... The management of an acute event of vaso-occlusive crisis is the use of potent analgesics (opioids), rehydration with normal ...
Most cases of angor animi are found in patients suffering from acute coronary syndrome (cardiac related chest pain) such as ... Irukandji syndrome is also another reported cause. Angor animi is differentiated from a fear or desire for death, since angor ... chest). Animi means an animating spirit, intention or temper. angor animi. Online Medical Dictionary. CancerWeb. Centre for ...
... implications for the transmission of severe acute respiratory syndrome". Chest. 125 (3): 1155-57. doi:10.1378/chest.125.3.1155 ... "Chest Meeting. 128 (4): 389S-390S. doi:10.1378/chest.128.4_meetingabstracts.389s-b.. [permanent dead link] ... "Chest. 132 (2): 540-46. doi:10.1378/chest.07-0636. PMID 17573505.. [permanent dead link] ... doi:10.1378/chest.09-2555. PMC 2897694. PMID 20605816.. *^ Cranston, Josephine M.; Crockett, Alan; Moss, John; Alpers, John H ...
... or acute chest syndrome. ... In the Cowden syndrome there is a mutation on the PTEN gene, ... Cutaneous photosensitivity; acute neurovisceral crises Medical procedure[edit]. Genetic testing is often done as part of a ... Fragile-X syndrome. Mental retardation or learning disabilities of unknown etiology; autism or autistic-like characteristics; ... The fluid is then tested for chromosomal abnormalities such as Down syndrome (Trisomy 21) and Trisomy 18, which can result in ...
"Steroids for acute respiratory distress syndrome?". Clinics in Chest Medicine. 35 (4): 781-95. doi:10.1016/j.ccm.2014.08.014. ... acute. Acute bronchitis. chronic. COPD Chronic bronchitis. Acute exacerbations of chronic bronchitis. Acute exacerbation of ... Acute renal failure. Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction ... Acute respiratory distress syndrome. Synonyms. Respiratory distress syndrome (RDS), adult respiratory distress syndrome, shock ...
... in people with chest pain or acute coronary syndrome. A person who recently had a myocardial infarction would have an area of ... 2001). "Acute coronary syndromes. The diagnostic role of troponins". Thromb Res. 103 (1): 63-69. doi:10.1016/S0049-3848(01) ... October 1996). "Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes ... "2014 AHA/ACC Guideline for the Management of Patients With Non-ST-Elevation Acute Coronary Syndromes: A Report of the American ...
... to be measured with troponin to identify myocardial infarction and acute coronary syndrome in patients presenting with chest ... "Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk ... H-FABP has been proven to significantly predict 30-day mortality in acute pulmonary embolism. H-FABP is more effective than ... H-FABP measured with troponin shows increased sensitivity of 20.6% over troponin at 3-6 hours following chest pain onset. This ...
Episodic transfusion is used either acutely in response to a complication of sickle cell disease such as acute chest syndrome ... Acute splenic sequestration associated with severe anemia requires a simple transfusion to raise the hemoglobin. Each unit of ... Transfusion therapy for sickle-cell disease entails the use of red blood cell transfusions in the management of acute cases of ...
"Selective dual nuclear scanning in low risk patients with chest pain to reliably identify and exclude acute coronary syndromes ... Fesmire FM, Fesmire CE (February 2000). "Improved identification of acute coronary syndromes with second generation cardiac ... Critical issues in the evaluation and management of adult patients with non-ST-segment elevation acute coronary syndromes". ... and selective nuclear stress testing to identify and exclude acute coronary syndromes". Annals of Emergency Medicine. 40 (6): ...
Morrison RJ, Bidani A. (2002) Acute respiratory distress syndrome epidemiology and pathophysiology. Chest Surg Clin N Am. 12: ... 2007) Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future ... 2011) The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 6:147-63. [2] Johnson ER, Matthay ... Clinically, the most serious and immediate complication is acute respiratory distress syndrome (ARDS), which usually occurs ...
... acute chest syndrome/sickle cell disease, amyloidosis, rheumatoid arthritis, membranous colitis, inhaled irritants, neoplastic ... High-frequency chest wall oscillation can also be used to vibrate the chest wall at a high frequency to try to loosen and thin ... Acute therapy for PB is often focused on removal or facilitated expectoration of the casts. This is followed by short and long ... Simple chest roentenograms may reveal collapse due to airway obstruction. The contralateral lung may be hyperinflated. Casts ...
... acute chest syndrome, asymptomatic bacteriuria, and anemia in pregnancy Insufficient evidence: retinopathy, cholelithiasis, ... Sheikha Anwar (2005). "Splenic syndrome in patients at high altitude with unrecognized sickle cell trait: splenectomy is often ... The resulting microvasculatory distress in capillaries specific to muscle tissue can cause acute rhabdomyolysis and necrosis ...
... severe acute respiratory syndrome (SARS) and measles. Chest radiographs (X-ray photographs) often show a pulmonary infection ... "Severe Acute Respiratory Syndrome (SARS) - multi-country outbreak". Archived from the original on 7 December 2008. Retrieved ... "Primary atypical pneumonia" at Dorland's Medical Dictionary Commission on Acute Respiratory Diseases, Fort Bragg, North ...
... or acute chest syndrome.. Tay-Sachs disease. Lipids accumulate in the brain; neurological dysfunction; progressive weakness and ... In the Cowden syndrome there is a mutation on the PTEN gene, causing potential breast, thyroid or endometrial cancer.[14] ... Fragile-X syndrome. Mental retardation or learning disabilities of unknown etiology; autism or autistic-like characteristics; ... The fluid is then tested for chromosomal abnormalities such as Down syndrome (Trisomy 21) and Trisomy 18, which can result in ...
"Value and limitations of chest pain history in the evaluation of patients with suspected acute coronary syndromes". JAMA. 294 ( ... A description of burning or indigestion-like pain increases the risk of acute coronary syndrome, but not to a statistically ... People with chest pain related to GERD are difficult to distinguish from those with chest pain due to cardiac conditions. Each ... As many as 30% of chest pain patients undergoing cardiac catheterization have findings which do not account for their chest ...
Many people with acute coronary syndromes present with symptoms other than chest pain, particularly, women, older patients, and ... Acute coronary syndrome (ACS) is a syndrome (set of signs and symptoms) due to decreased blood flow in the coronary arteries ... Allergic acute coronary syndrome (Kounis syndrome) Amsterdam, E. A.; Wenger, N. K.; Brindis, R. G.; Casey, D. E.; Ganiats, T. G ... "Clinical diagnosis of acute coronary syndrome in patients with chest pain and a normal or non-diagnostic electrocardiogram". ...
The Acute Chest Syndrome". Knight-Madden, JM; Hambleton, IR (Aug 2, 2014). "Inhaled bronchodilators for acute chest syndrome in ... The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell ... Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation ... Acute chest syndrome is an indication for exchange transfusion. Bronchodilators may be useful but have not been well studied. ...
... decision rule for chest radiography in emergency department patients with chest pain and possible acute coronary syndrome". ... Chest pain is pain in any region of the chest. Chest pain may be a symptom of a number of serious disorders and is, in general ... Chest pain can be differentiated into heart-related and non heart related chest pain.[1][2][3] Cardiac chest pain is called ... These include chest pain described as "sharp" or "stabbing", chest pain that is positional or pleuritic in nature, and chest ...
"Steroids for acute respiratory distress syndrome?". Clinics in chest medicine. 35 (4): 781-95. doi:10.1016/j.ccm.2014.08.014. ... Bakowitz, Magdalena (August 2012). "Acute lung injury and the acute respiratory distress syndrome in the injured patient". ... to families/victims of Acute Respiratory Distress Syndrome MESENCHYMAL STEM CELLS AND THE ACUTE RESPIRATORY DISTRESS SYNDROME. ... acute lung injury, and acute respiratory distress syndrome: time for a reevaluation". Critical Care Medicine. 28 (1): 232-235. ...
... implications for the transmission of severe acute respiratory syndrome". Chest. 125 (3): 1155-7. doi:10.1378/chest.125.3.1155. ... Chest Meeting. 128 (4): 389S-390S. doi:10.1378/chest.128.4_meetingabstracts.389s-b. Earl, John. Delivery of High FiO 2. ... Chest. 138 (1): 179-87. doi:10.1378/chest.09-2555. PMC 2897694 . PMID 20605816. "Continuous or nocturnal oxygen therapy in ... Oxygen is used as a medical treatment in both chronic and acute cases, and can be used in hospital, pre-hospital or entirely ...
This is achieved with urgent hospitalization and medical therapy, including drugs that relieve chest pain and reduce the size ... people who present with angina must prompt evaluation for possible acute coronary syndrome. Acute coronary syndromes are ... Management of acute coronary syndrome is targeted against the effects of reduced blood flow to the afflicted area of the heart ... Acute coronary syndromes are caused by sudden and critical reduction of blood flow in one of the coronary arteries, the vessels ...
... syndrome Acute aortic syndrome Acute brain syndrome Acute chest syndrome Acute coronary syndrome Acute HME syndrome Acute ... activation syndrome Acute radiation syndrome Acute respiratory distress syndrome Acute retroviral syndrome Adams-Nance syndrome ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... Setleis syndrome Severe acute respiratory syndrome Shaken baby syndrome Shapiro syndrome Sheehan's syndrome Shell nail syndrome ...
These invasive pneumococcal diseases include bronchitis, rhinitis, acute sinusitis, otitis media, conjunctivitis, meningitis, ... and chest pain. For the elderly, they may include confusion, low alertness, and the former listed symptoms to a lesser degree. ... "Penicillin-resistant Streptococcus pneumoniae in acute otitis media: risk factors, susceptibility patterns and antimicrobial ...
... although it should be noted that chest radiographicchanges are often not apparent in the initialstages of the syndrome. An ECG ... She had no long-term sequelae of herembolization event.DiscussionThe workup of a patient with acute onset of shortnessof breath ... The fat embolism syndrome was firstdescribed clinically by Von Bergmann,6 who caredfor a man with a broken femur and symptoms ... syndrome have long been debated in the. literature. The theoretical basis for using corticosteroids. is sound; they are thought ...
... although it should be noted that chest radiographic changes are often not apparent in the initial stages of the syndrome. An ... The workup of a patient with acute onset of shortness of breath after an orthopedic operative procedure should include ... who cared for a man with a broken femur and symptoms of the syndrome in 1873. The prevalence of fat embolism syndrome among all ... Fat embolism syndrome can occur in immediate conjunction with a precipitating factor or it can be delayed for up to 3 days, ...
Definition of acute chest syndrome. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... acute chest syndrome. Definition: a syndrome occurring in association with sickle cell disease defined by a new infiltrate on ... chest radiograph; associated with one or more new symptoms: fever, cough, sputum production, dyspnea, or hypoxia. It occurs ...
Sickle Cell Patients with Acute Chest Syndrome Sickle cell patients with active acute chest syndrome (ACS) from which samples ... Syndrome. Anemia, Sickle Cell. Acute Chest Syndrome. Disease. Pathologic Processes. Anemia, Hemolytic, Congenital. Anemia, ... sPLA2 in EBC During Acute Chest Syndrome. The safety and scientific validity of this study is the responsibility of the study ... Definition of acute chest syndrome to be used: New radiographic pulmonary infiltrate of at least one complete lung segment in ...
Preventing Acute Chest Syndrome by Transfusion Feasibility Study. Official Title ICMJE Preventing Acute Chest Syndrome by ... Acute Chest Syndrome [ Time Frame: Chest x-rays (CXR) were ordered for trial eligibility, as a result of clinical indications, ... Preventing Acute Chest Syndrome by Transfusion Feasibility Study (PROACTIVE). The safety and scientific validity of this study ... Acute chest syndrome (ACS) is similar to severe pneumonia and is a common cause of hospitalizations for people with sickle cell ...
Morphine is associated with acute chest syndrome in children hospitalized with sickle cell disease.. Birken CS1, Khambalia A, ... To determine if intravenous morphine is associated with acute chest syndrome (ACS) in children with homozygous for hemoglobin S ... Health records of patients with homozygous for hemoglobin S SCD aged 2 to 18 years hospitalized with acute pain were reviewed. ... sickle cell disease (SCD) hospitalized with acute pain.. METHODS: ...
The Acute Chest Syndrome". Knight-Madden, JM; Hambleton, IR (Aug 2, 2014). "Inhaled bronchodilators for acute chest syndrome in ... The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell ... Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation ... Acute chest syndrome is an indication for exchange transfusion. Bronchodilators may be useful but have not been well studied. ...
Until tests give a diagnosis doctors may describe your condition as Acute Coronary Syndrome (ACS). ... Sometimes chest pain occurs due to an unknown cause. ... Acute coronary syndrome (ACS). *Angina*How will I know if I ... Coronavirus & Chest Conditions. If you have a chest condition and you are worried about coronavirus. Coronavirus and chest ... Heart Information and Support , About your heart condition , Common heart conditions , Acute coronary syndrome (ACS) ...
Sickle Cell Disease: Acute Chest Syndrome. Topic Overview. Acute chest syndrome is a lung-related complication of sickle cell ... Treatment of acute chest syndrome includes:. *Encouraging deep breathing. This is especially important when a person has chest ... Repeat occurrences of acute chest syndrome can cause lung damage. This condition develops more often in young children but is ... Because a person with acute chest syndrome can deteriorate rapidly, a hospital stay is usually needed. Some cases are mild and ...
1994). The Acute Chest Syndrome in Sickle-Cell Disease - Incidence and Risk-Factors. Blood, 84(2), 643-649. ... The Acute Chest Syndrome in Sickle-Cell Disease - Incidence and Risk-Factors. ...
Learn about symptoms and treatment for acute chest syndrome. ... Acute chest syndrome is a complication (health problem) caused ... What is acute chest syndrome?. Acute chest syndrome (ACS) is a complication (health problem) caused by sickle cell disease. It ... What causes acute chest syndrome?. Sickle red blood cells can block the blood vessels in the lungs. This reduces oxygen flow to ... What is the treatment for acute chest syndrome?. Your child will be admitted to the hospital, and the staff will need to take ...
Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome.(Case Report, Case study) by ... APA style: Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome.. (n.d.) >The Free ... MLA style: "Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome.." The Free ... S.v. Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome.." Retrieved Jul 18 2019 ...
... Hazel ... "Pulmonary Thromboembolism in a Child with Sickle Cell Hemoglobin D Disease in the Setting of Acute Chest Syndrome," Case ...
People with sickle cell disease may have the acute onset of chest problems which may include fever, this is called acute chest ... Acute chest syndrome is a frequent complication of sickle cell disease, as well as a major cause of morbidity and the greatest ... Blood transfusions for treating acute chest syndrome in people with sickle cell disease. Review question ... Thereore, this unique study did not show how effective blood transfusions might be for treating acute chest syndrome in people ...
Improved Assessment of Chest pain Trial (IMPACT): assessing patients with possible acute coronary syndrome. ...
Are you sure your patient has acute chest syndrome? What are the typical findings for this disease?. Acute chest syndrome (ACS ... What are the possible outcomes of acute chest syndrome?. During an ACS, there is an increased risk of posterior reversible ... Are you sure your patient has acute chest syndrome? What are the typical findings for this disease? ... Chest radiography should be performed in patients with fever, shortness of breath, tachypnea, cough, rales or chest pain and of ...
An Issue Of Clinics In Chest Medicine by Lorraine B. Ware at Indigo.ca, Canadas largest bookstore. + Get Free Shipping on ... Buy the Hardcover Book Acute Respiratory Distress Syndrome, ... Title:Acute Respiratory Distress Syndrome, An Issue Of Clinics ... Acute Respiratory Distress Syndrome, An Issue Of Clinics In Chest Medicine. byLorraine B. WareEditorLorraine B. Ware. Hardcover ... Customer Reviews of Acute Respiratory Distress Syndrome, An Issue Of Clinics In Chest Medicine. ...
acute chest syndrome. New insights into the pathophysiology of acute chest syndrome (ACS) have highlighted potential ... A repeat chest radiograph showed new infiltrates in both lower zones and a diagnosis of acute sickle chest syndrome (ACS) was ... Management of acute chest syndrome. Most adult patients are admitted with vaso-occlusive crises and develop ACS after a few ... Pathophysiology of the acute chest syndrome in sickle cell disease. The genetic defect in sickle cell anaemia causes a ...
Abstract 343: Chest Pain Patients at Low Risk for Acute Coronary Syndrome: 30 Day Implications of 25-50% Diameter Coronary ... Abstract 343: Chest Pain Patients at Low Risk for Acute Coronary Syndrome: 30 Day Implications of 25-50% Diameter Coronary ... Abstract 343: Chest Pain Patients at Low Risk for Acute Coronary Syndrome: 30 Day Implications of 25-50% Diameter Coronary ... Abstract 343: Chest Pain Patients at Low Risk for Acute Coronary Syndrome: 30 Day Implications of 25-50% Diameter Coronary ...
... the fundamentals of the emergency department evaluation of patients determined to be at low risk for acute coronary syndromes ... Identifying Emergency Department Patients With Chest Pain Who Are at Low Risk for Acute Coronary Syndromes. Download PDF ... Home , All Topics , Identifying Emergency Department Patients With Chest Pain Who Are at Low Risk for Acute Coronary Syndromes ... Identifying Emergency Department Patients With Chest Pain Who Are at Low Risk for Acute Coronary Syndromes. ...
Home » Blog » News » Heme oxygenase1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome ... Heme oxygenase1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with ... This project is supported in part by the NIH Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network ...
Admission glycaemia and its association with acute coronary syndrome in Emergency Department patients with chest pain ... Admission glycaemia and its association with acute coronary syndrome in Emergency Department patients with chest pain ... Admission BGL is a prognostic indicator in patients with confirmed acute coronary syndrome (ACS). It is unclear if admission ...
3 has been shown to rule out an acute coronary syndrome (ACS) with a low risk of major adverse cardiac event (MACE)... ... In patients consulting in the Emergency Department for chest pain, a HEART score ≤ ... Chest pain Major adverse cardiac event Acute coronary syndrome Risk assessment This is a preview of subscription content, log ... Reliability of the CARE rule and the HEART score to rule out an acute coronary syndrome in non-traumatic chest pain patients. ...
Serial multiple biomarkers in the assessment of suspected acute coronary syndrome: multiple infarct markers in chest pain ( ... Serial multiple biomarkers in the assessment of suspected acute coronary syndrome: multiple infarct markers in chest pain ( ... Serial multiple biomarkers in the assessment of suspected acute coronary syndrome: multiple infarct markers in chest pain ( ...
Abstract 157: Use of a Novel Risk Score in the Emergency Department Discriminates Acute Coronary Syndrome Among Chest Pain ... Abstract 157: Use of a Novel Risk Score in the Emergency Department Discriminates Acute Coronary Syndrome Among Chest Pain ... Abstract 157: Use of a Novel Risk Score in the Emergency Department Discriminates Acute Coronary Syndrome Among Chest Pain ... Abstract 157: Use of a Novel Risk Score in the Emergency Department Discriminates Acute Coronary Syndrome Among Chest Pain ...
  • The purpose of this research study is to test the ease and effectiveness of collecting exhaled breath condensate (liquid) to measure levels of a biomarker, secretory phospholipases A2 (sPLA2) in people with sickle cell disease during an attack of acute chest syndrome. (clinicaltrials.gov)
  • People with sickle cell disease may have the acute onset of chest problems which may include fever, this is called acute chest syndrome. (cochrane.org)
  • Thereore, this unique study did not show how effective blood transfusions might be for treating acute chest syndrome in people with sickle cell disease. (cochrane.org)
  • Therefore, future research is needed to provide evidence for people to make informed decisions on whether blood transfusions are effective for treating acute chest syndrome in people with sickle cell disease. (cochrane.org)
  • Acute chest syndrome (ACS) is the second most common reason for hospitalization of children with sickle cell disease (SCD) and is a leading cause of mortality. (clinicaladvisor.com)
  • Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease. (inserm.fr)
  • Adhering to guidelines for antibiotic treatment of acute chest syndrome in children with sickle cell disease (SCD) is associated with reduced readmission rates, according to a retrospective cohort study. (acepnow.com)
  • Mary Cataletto from Stony Brook University's school of medicine said, "Management of acute chest syndrome is a major challenge for physicians and other healthcare providers caring for children with sickle cell disease . (femaleadda.com)
  • Acute chest syndrome (ACS) is the most prominent cause of mortality in children with sickle cell disease. (emjreviews.com)
  • We hypothesized that children with sickle cell disease with concomitant asthma have an increased incidence of vaso-occlusive crises that are complicated by episodes of acute chest syndrome. (biomedcentral.com)
  • Children with sickle cell disease and asthma had significantly more episodes of acute chest syndrome (p = 0.03) and cerebral vascular accidents (p = 0.05) compared to children with sickle cell disease without asthma. (biomedcentral.com)
  • Sickle cell patients with active acute chest syndrome (ACS) from which samples of EBC and plasma will be collected during acute illness within 48 hours of admission with or diagnosis of ACS (Time point 1) in 3 sessions each 1 hour apart (Time point 1a, 1b, and 1c), and 2 weeks after discharge when have returned to steady-state (Time point 2). (clinicaltrials.gov)
  • Comparison of sPLA2 levels in EBC from Time point 1 (during acute illness) and Time Point 2 (return to baseline status at 2 week follow up). (clinicaltrials.gov)
  • A novel risk score including elevated troponin I in the ED, dynamic ECG changes in the ED, body mass index, home aspirin use, age older than 65, history of chronic kidney disease, and associated illness at presentation to the ED, is a valuable tool for discriminating between ACS and non-ACS among patients with known CAD presenting to the ED with chest pain. (ahajournals.org)
  • Identify and treat all underlying factors precipitating acute illness. (cancertherapyadvisor.com)
  • Sickle cell disease is characterised by unpredictable episodes of acute illness, progressive organ damage, and a lack of effective treatments. (bmj.com)
  • Family physicians play a crucial role in instituting evidence-based preventive care strategies, initiating timely treatment of acute illness, recognizing life-threatening episodes, and providing a medical home for multidisciplinary management. (aafp.org)
  • they were specifically asked to report only confirmed COVID-19 cases and to report cases after resolution of acute illness or death. (cdc.gov)
  • Sickle cell disease can produce an acute illness related to infarction of the lung tissue. (rch.org.au)
  • Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation leads to further sickling of red cells, thus exacerbating pulmonary and systemic hypoxemia, sickling, and vaso-occlusion. (wikipedia.org)
  • A lung infection may accompany acute chest syndrome. (lifescript.com)
  • Hydroxyurea is a medication that can help to prevent acute chest syndrome. (wikipedia.org)
  • Acute chest syndrome is a leading cause of hospitalization and death in children and adults with SCD. (acepnow.com)
  • Readmissions for acute chest syndrome and all-cause readmissions at 7 and 30 days after hospitalization were lowest in the guideline-adherent antibiotic group, second lowest in the group that received parenteral cephalosporins without macrolides, and highest (except for 7-day readmissions for acute chest syndrome) after hospitalizations involving neither antibiotic. (acepnow.com)
  • Antibiotics, hospitalization, and incentive spirometry are indicated for those with acute chest syndrome. (aafp.org)
  • Children with concomitant asthma and sickle cell disease have increased episodes of acute chest syndrome, cerebral vascular accidents and the need for blood transfusions. (biomedcentral.com)
  • Progressive restrictive lung disease related to recurrent episodes of acute chest syndrome may develop with advancing age [ 3 ]. (biomedcentral.com)
  • Serial monitoring of plasma sPLA2 levels might lead to earlier or more accurate detection of acute chest syndrome and monitoring of its progression or improvement in patients with sickle cell disease. (clinicaltrials.gov)
  • Dual-energy computed tomography perfusion imaging is a promising adjunct in the detection of acute PE providing simultaneous f. (bioportfolio.com)
  • Acute chest syndrome (ACS) is the main cause of morbi-mortality in patients with sickle-cell disease in the intensive care unit (ICU). (springeropen.com)
  • Progress made in its management led to increased life expectancy in developed countries [ 2 ], however patients with SCD are still at risk of early mortality due to acute chest syndrome (ACS) [ 1 ]. (springeropen.com)
  • Acute pulmonary embolism is a potentially life-threatening disease with short-term mortality ranges from less than 1% to more than 30% during the hospital stay. (bioportfolio.com)