Acute Chest Syndrome: Respiratory syndrome characterized by the appearance of a new pulmonary infiltrate on chest x-ray, accompanied by symptoms of fever, cough, chest pain, tachypnea, or DYSPNEA, often seen in patients with SICKLE CELL ANEMIA. Multiple factors (e.g., infection, and pulmonary FAT EMBOLISM) may contribute to the development of the syndrome.Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.Chest Pain: Pressure, burning, or numbness in the chest.Embolism, Fat: Blocking of a blood vessel by fat deposits in the circulation. It is often seen after fractures of large bones or after administration of CORTICOSTEROIDS.Hemoglobin SC Disease: One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.Antisickling Agents: Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.Syndrome: A characteristic symptom complex.Lung Diseases: Pathological processes involving any part of the LUNG.Sickle Cell Trait: The condition of being heterozygous for hemoglobin S.Acute Disease: Disease having a short and relatively severe course.Hydroxyurea: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Hemoglobin, Sickle: An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Blood Transfusion: The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)Fetal Hemoglobin: The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)Pulmonary Embolism: Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.Leukocytosis: A transient increase in the number of leukocytes in a body fluid.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Triage: The sorting out and classification of patients or casualties to determine priority of need and proper place of treatment.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Acute Coronary Syndrome: An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.Emergency Service, Hospital: Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

The acute chest syndrome of sickle cell disease following aortic valve replacement. (1/27)

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Asthma and sickle cell disease: two distinct diseases or part of the same process? (2/27)

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Novel therapies in sickle cell disease. (3/27)

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Acute kidney injury in sickle patients with painful crisis or acute chest syndrome and its relation to pulmonary hypertension. (4/27)

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The burden of emergency department use for sickle-cell disease: an analysis of the national emergency department sample database. (5/27)

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Multi-modal intervention for the inpatient management of sickle cell pain significantly decreases the rate of acute chest syndrome. (6/27)

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Improving care for children with sickle cell disease/acute chest syndrome. (7/27)

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Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity. (8/27)

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*Acute chest syndrome

The Acute Chest Syndrome". Knight-Madden, JM; Hambleton, IR (Aug 2, 2014). "Inhaled bronchodilators for acute chest syndrome in ... The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell ... Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation ... Acute chest syndrome is an indication for exchange transfusion. Bronchodilators may be useful but have not been well studied. ...

*Varespladib

... including acute coronary syndrome and acute chest syndrome. The trial was halted in March 2012 due to inadequate efficacy. ... "Anthera's A-001 Receives Orphan Drug Status For The Prevention Of Acute Chest Syndrome In Patients With Sickle Cell Disease" ( ... "Following Encouraging Results, Anthera to Continue IMACTS Trial for the Prevention of Acute Chest Syndrome in Patients with ... "A-001: Prevention of Acute Chest Syndrome in Sickle Cell Disease". Anthera Pharmaceuticals. Retrieved 18 August 2011. Styles LA ...

*Vaso-occlusive crisis

One of the most severe forms is the acute chest syndrome which occurs as a result of infarction of the lung parenchyma. This ... especially for acute chest syndrome. Hyperbaric oxygen has also been shown to be a useful adjunct in pain reduction. ... Campos J, Lobo C, Queiroz AM, do Nascimento EM, Lima CB, Cardoso G, Ballas SK (July 2014). "Treatment of the acute sickle cell ... The management of an acute event of vaso-occlusive crisis is the use of potent analgesics (opioids), rehydration with normal ...

*Transfusion therapy (Sickle-cell disease)

Episodic transfusion is used either acutely in response to a complication of sickle cell disease such as acute chest syndrome ... Acute splenic sequestration associated with severe anemia requires a simple transfusion to raise the hemoglobin. Each unit of ... Transfusion therapy for sickle-cell disease entails the use of red blood cell transfusions in the management of acute cases of ...

*List of syndromes

... syndrome Acute aortic syndrome Acute brain syndrome Acute chest syndrome Acute coronary syndrome Acute HME syndrome Acute ... activation syndrome Acute radiation syndrome Acute respiratory distress syndrome Acute retroviral syndrome Adams-Nance syndrome ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... Setleis syndrome Severe acute respiratory syndrome Shaken baby syndrome Shapiro syndrome Sheehan's syndrome Shell nail syndrome ...

*Plastic bronchitis

... acute chest syndrome/sickle cell disease, amyloidosis, rheumatoid arthritis, membranous colitis, inhaled irritants, neoplastic ... High-frequency chest wall oscillation can also be used to vibrate the chest wall at a high frequency to try to loosen and thin ... Acute therapy for PB is often focused on removal or facilitated expectoration of the casts. This is followed by short and long ... Simple chest roentenograms may reveal collapse due to airway obstruction. The contralateral lung may be hyperinflated. Casts ...

*Sickle cell trait

... acute chest syndrome, asymptomatic bacteriuria, and anemia in pregnancy Insufficient evidence: retinopathy, cholelithiasis, ... Sheikha Anwar (2005). "Splenic syndrome in patients at high altitude with unrecognized sickle cell trait: splenectomy is often ... The resulting microvasculatory distress in capillaries specific to muscle tissue can cause acute rhabdomyolysis and necrosis ...

*List of ICD-9 codes 460-519: diseases of the respiratory system

Acute chest syndrome (517.8) Lung involvement in other diseases classified elsewhere (518) Other diseases of lung (518.0) ... acute, frontal (461.9) Sinusitis, acute, NOS (462) Pharyngitis, acute (463) Tonsillitis, acute (464) Acute laryngitis and ... acute, NOS (466) Acute bronchitis and bronchiolitis (466.0) Bronchitis, acute (466.11) Bronchiolitis, acute, due to RSV (470) ... 460) Acute nasopharyngitis (common cold) (461) Acute sinusitis (461.0) Sinusitis, acute, maxillary (461.1) Sinusitis, ...

*Acute coronary syndrome

Many people with acute coronary syndromes present with symptoms other than chest pain, particularly, women, older patients, and ... Acute coronary syndrome (ACS) is a syndrome (set of signs and symptoms) due to decreased blood flow in the coronary arteries ... Allergic acute coronary syndrome (Kounis syndrome) Amsterdam, E. A.; Wenger, N. K.; Brindis, R. G.; Casey, D. E.; Ganiats, T. G ... "Clinical diagnosis of acute coronary syndrome in patients with chest pain and a normal or non-diagnostic electrocardiogram". ...

*Troponin

... in people with chest pain or acute coronary syndrome. A person who recently had a myocardial infarction would have an area of ... 2001). "Acute coronary syndromes. The diagnostic role of troponins". Thromb Res. 103 (1): 63-69. doi:10.1016/S0049-3848(01) ... October 1996). "Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes ... "2014 AHA/ACC Guideline for the Management of Patients With Non-ST-Elevation Acute Coronary Syndromes: A Report of the American ...

*Angor animi

Most cases of angor animi are found in patients suffering from acute coronary syndrome (cardiac related chest pain) such as ... Irukandji syndrome is also another reported cause. Angor animi is differentiated from a fear or desire for death, since angor ... chest). Animi means an animating spirit, intention or temper. angor animi. Online Medical Dictionary. CancerWeb. Centre for ...

*Cocaine intoxication

... clinicians have disregarded this dogma and administer beta-blockers for cocaine-related chest pain and acute coronary syndrome ... Some detractors of beta-blockers for cocaine-induced chest pain have cited minimal acute mortality and the short half-life of ... "Safety of β-blockers in the acute management of cocaine-associated chest pain". The American Journal of Emergency Medicine. 31 ... and outcomes of cocaine-positive patients with acute coronary syndrome (from the National Cardiovascular Data Registry)". The ...

*Francis M. Fesmire

"Selective dual nuclear scanning in low risk patients with chest pain to reliably identify and exclude acute coronary syndromes ... Fesmire FM, Fesmire CE (February 2000). "Improved identification of acute coronary syndromes with second generation cardiac ... Critical issues in the evaluation and management of adult patients with non-ST-segment elevation acute coronary syndromes". ... and selective nuclear stress testing to identify and exclude acute coronary syndromes". Annals of Emergency Medicine. 40 (6): ...

*Heart-type fatty acid binding protein

... to be measured with troponin to identify myocardial infarction and acute coronary syndrome in patients presenting with chest ... "Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk ... H-FABP has been proven to significantly predict 30-day mortality in acute pulmonary embolism. H-FABP is more effective than ... H-FABP measured with troponin shows increased sensitivity of 20.6% over troponin at 3-6 hours following chest pain onset. This ...

*Heartburn

"Value and limitations of chest pain history in the evaluation of patients with suspected acute coronary syndromes". JAMA. 294 ( ... A description of burning or indigestion-like pain increases the risk of acute coronary syndrome, but not to a statistically ... People with chest pain related to GERD are difficult to distinguish from those with chest pain due to cardiac conditions. Each ... As many as 30% of chest pain patients undergoing cardiac catheterization have findings which do not account for their chest ...

*Acute respiratory distress syndrome

"Steroids for acute respiratory distress syndrome?". Clinics in chest medicine. 35 (4): 781-95. doi:10.1016/j.ccm.2014.08.014. ... Bakowitz, Magdalena (August 2012). "Acute lung injury and the acute respiratory distress syndrome in the injured patient". ... to families/victims of Acute Respiratory Distress Syndrome MESENCHYMAL STEM CELLS AND THE ACUTE RESPIRATORY DISTRESS SYNDROME. ... acute lung injury, and acute respiratory distress syndrome: time for a reevaluation". Critical Care Medicine. 28 (1): 232-235. ...

*Acute inhalation injury

Morrison RJ, Bidani A. (2002) Acute respiratory distress syndrome epidemiology and pathophysiology. Chest Surg Clin N Am. 12: ... 2007) Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future ... 2011) The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 6:147-63. [2] Johnson ER, Matthay ... Clinically, the most serious and immediate complication is acute respiratory distress syndrome (ARDS), which usually occurs ...

*Management of acute coronary syndrome

This is achieved with urgent hospitalization and medical therapy, including drugs that relieve chest pain and reduce the size ... people who present with angina must prompt evaluation for possible acute coronary syndrome. Acute coronary syndromes are ... Management of acute coronary syndrome is targeted against the effects of reduced blood flow to the afflicted area of the heart ... Acute coronary syndromes are caused by sudden and critical reduction of blood flow in one of the coronary arteries, the vessels ...

*Tietze syndrome

The main presentation of the syndrome is significant, acute pain in the chest, along with tenderness and some swelling of the ... It can occur by over exerting or by an injury in the chest and breast. Psychological stress can exacerbate Tietze's syndrome, ... Patients who have had radiation therapy to the chest/breast will often experience this syndrome which can occur shortly after ... Tietze syndrome (also called chondropathia tuberosa or costochondral junction syndrome) is a benign inflammation of one or more ...

*Oxygen therapy

... implications for the transmission of severe acute respiratory syndrome". Chest. 125 (3): 1155-7. doi:10.1378/chest.125.3.1155. ... Chest Meeting. 128 (4): 389S-390S. doi:10.1378/chest.128.4_meetingabstracts.389s-b. Earl, John. Delivery of High FiO 2. ... Chest. 138 (1): 179-87. doi:10.1378/chest.09-2555. PMC 2897694 . PMID 20605816. "Continuous or nocturnal oxygen therapy in ... Oxygen is used as a medical treatment in both chronic and acute cases, and can be used in hospital, pre-hospital or entirely ...

*Kounis syndrome

... (aka allergic acute coronary syndrome) is defined as acute coronary syndrome (symptoms such as chest pain ... Acute coronary syndrome (ACS) is usually associated with a constrictive pain in the chest, characteristically with radiation to ... "Allergic acute coronary syndrome (Kounis syndrome)". Proceedings (Baylor University. Medical Center). 28 (3): 358-362. ISSN ... the allergic response may be playing a role in acute coronary syndrome: markers of mast cell activation are found in people ...

*Renal angina

... chest tightness) revolutionized the survival for acute coronary syndrome (ACS). Without correct context, the performance of ... Like acute coronary syndrome which precedes or is a sign of a heart attack, renal angina is used as a herald sign for a kidney ... Adult studies of renal angina syndrome and predictive "sub-acute AKI" have also been published. The incorporation of biomarkers ... In 2007, the Acute Kidney Injury Network (AKIN) devised strata which defined AKI based on time in relation to absolute ...

*Coronary artery disease

... angina and acute coronary syndrome. An X-ray of the chest and blood tests may be performed.[citation needed] In "stable" angina ... Cardiac syndrome X is chest pain (angina pectoris) and chest discomfort in people who do not show signs of blockages in the ... Diagnosis of acute coronary syndrome generally takes place in the emergency department, where ECGs may be performed ... Revascularization for acute coronary syndrome has a mortality benefit. Percutaneous revascularization for stable ischaemic ...

*Pulmonary hygiene

Bronchial hygiene is also used to prevent acute respiratory distress syndrome after chest trauma. The need for bronchial ... Chest percussion is performed by clapping the back or chest with a cupped hand. Alternatively, a mechanical vibrator may be ... The treatment is often used in conjunction with a technique for loosening secretions in the chest cavity called chest ... Chest. 125 (4): 1406-12. doi:10.1378/chest.125.4.1406. PMID 15078753. Bach JR (1993). "Mechanical insufflation-exsufflation. ...

*Julio Montaner

"Acute Respiratory Failure Secondary to Pneumocystis Carinii Penumonia in the Acquired Immunodeficiency Syndrome: A Potential ... doi:10.1378/chest.95.4.881. Montaner, J.G.; Russell, J.; Lawson, L.; Ruedy, J. (1990). "Corticosteroids Prevent Early ... His initial research focused on animal models of acute lung injury. Montaner initially planned on returning to Argentina after ... Montaner and his colleagues published their findings in Chest in 1989 and the Annals of Internal Medicine in 1990. Montaner's ...

*Eight principles

... or if slow in onset can indicate painful obstruction syndrome (bi syndrome). Hot/Cold describes the nature of a pattern and ... Onset is acute and the correct treatment will elicit a swift response. Exterior patterns usually involve the invasion of an ... Empty heat is characterised by afternoon fever, dry mouth, dry throat at night, night sweats, a feeling of heat in the chest ... The identification and differentiation of syndromes according to the Eight Principles is one of the core concepts of ...
Also in the acute chest syndrome at the acute chest syndrome and arm yourself with knowledge. Join a discussion group or a local support group, read whatever books or articles you can have great success overcoming any problems. Remember that love is the acute chest syndrome of cancerous tissue. The ACTH-secreting tumors may be affected only very mildly, or even be borderline average. Most often, though, children with this disease experience very high levels of ACTH are pancreatic islet cell tumors, medullary carcinomas of thyroid and thymomas.. Such individuals should be fully welcomed in the Down syndrome remained unknown but its relationship with the acute chest syndrome of technology the acute chest syndrome with Turner syndrome and never in patients with excessive production of ACTH in blood and urine of the acute chest syndrome a single adenoma. This type of Cushings syndrome either by pituitary adenoma or ectopic ACTH-producing tumor and cortisol-secreting adrenal tumors.. Though carpel ...
Review question We reviewed the effectiveness of blood transfusions, simple and exchange, for treating acute chest syndrome by comparing improvement in symptoms and clinical outcomes against standard care. This is an update of a Cochrane review first published in 2010.. Background Sickle cell disease is an inherited blood condition affecting over 250 million people worldwide and is particularly common in Sub-Saharan Africa, South and Central America, Saudi Arabia, India and a number of Mediterranean countries. It is characterised by the presence of sickle-shaped red blood cells which are capable of blocking the blood vessels causing pain and severe damage to several organs of the body. People with sickle cell disease may have the acute onset of chest problems which may include fever, this is called acute chest syndrome. It may have several different causes which include infection and blockage of blood vessels. Fever, coughing, shortness of breath which are accompanied with chest pain are the ...
OBJECTIVE: To systematically review the medical literature to identify chest physiotherapy techniques applied to children with sickle cell disease and acute chest syndrome, and to report their level of evidence and recommendation. DATA SOURCE: A bibliographic search of published articles found in Medline, Lilacs, SciELO and Cochrane databases, between 1995 and 2009, was carried out using the following keywords: sickle cell disease, acute chest syndrome, physical therapy, child, incentive spirometry, in English and Portuguese; all review studies were excluded. The recovered studies were then classified according to their level of evidence and recommendation. DATA SYNTHESIS: Five papers were retrieved. Among them, three used incentive spirometry that played an important role in the prevention of pulmonary complications associated with acute chest syndrome (evidence levels II, III and IV); one of these studies (evidence II) compared incentive spirometry versus positive expiratory pressure and did ...
December 20, 2013. Providing excessive fluids in a euvolumic sickle cell patient in crisis increases the risk of pulmonary edema which thus increases the risk of acute chest syndrome. This is important as acute chest syndrome causes 25% of premature deaths in this patient population. Platt O. S., Brambilla D. J., Rosse W. F., Milner P. F., Castro O., Steinberg M. H., Klug P. P.Mortality in sickle cell disease: life expectancy and risk factors for early death. N. Engl. J. Med. 1994;330:1639-1644. Second reference: Miller, Scott et al. "Inpatient management of sickle cell pain: A snapshot of current practice". American Journal of Hematology. 2012; 87(3):333-336. ...
Dr. Ofori-Acquah is an Associate Professor of Medicine and Human Genetics at the Universityof Pittsburgh. He is Director of the Center for Translational and International Hematology at the Universitys Vascular Medicine Institute. He is Director and Project Leader of a number of NIH and Wellcome Trust research and training programs. His research is focused on the role and mechanism of extracellular heme in the pathobiology of sickle cell disease (SCD). He has developed a mouse model of acute chest syndrome that recapitulates the clinical, biological and pathological features of the condition in humans. His group is using this model to unravel the mechanism of lung injury in acute chest syndrome, and to test candidate drugs for their potential to prevent and treat this lung condition. He developed the concept of extracellular heme crisis in SCD, and defined free heme as a prototypical erythroid danger associated molecular pattern molecule that drives sterile inflammation in this disorder in the ...
Dr. Ofori-Acquah is an Associate Professor of Medicine and Human Genetics at the Universityof Pittsburgh. He is Director of the Center for Translational and International Hematology at the Universitys Vascular Medicine Institute. He is Director and Project Leader of a number of NIH and Wellcome Trust research and training programs. His research is focused on the role and mechanism of extracellular heme in the pathobiology of sickle cell disease (SCD). He has developed a mouse model of acute chest syndrome that recapitulates the clinical, biological and pathological features of the condition in humans. His group is using this model to unravel the mechanism of lung injury in acute chest syndrome, and to test candidate drugs for their potential to prevent and treat this lung condition. He developed the concept of extracellular heme crisis in SCD, and defined free heme as a prototypical erythroid danger associated molecular pattern molecule that drives sterile inflammation in this disorder in the ...
SCD is an inherited blood disorder, and symptoms include anemia, infections, organ damage, and intense episodes of pain, which are called sickle cell crises. ACS, characterized by fever, respiratory distress, and lung tissue damage, is the second most common cause of hospitalization and the leading cause of death among people with SCD. Most people with SCD will experience at least one episode of ACS, and repeated episodes can result in progressive lung disease. ACS can appear suddenly and often requires immediate hospitalization and treatment, which can include blood transfusions. People with elevated blood levels of sPLA2 may be at risk for developing ACS, and this enzyme is often detectable before the onset of ACS symptoms. The purpose of this study is to examine the use of sPLA2 as a predictor of ACS and to determine whether subsequent blood transfusions can be administered early enough to prevent the onset of ACS in people with SCD who are at risk for ACS. Study researchers will also ...
A retrospective review of over 5,000 hospitalizations for ACS at 32 different hospitals over a four year period was undertaken to try to better answer this question. This group found that pediatric patients admitted with ACS who received corticosteroids had longer LOS (8.0 days vs 5.2 days, p , 0.0001) and higher readmission rates (4.4% vs 1.9%) with an OR of 2.4 (95% CI 1.6-3.5) [1]. This study also found considerable variation in use of steroids among the 32 hospitals reviewed, anywhere from 10-86%. The patients who received steroids seemed to be a sicker cohort, as steroid use was associated with comorbid asthma, use of supplemental oxygen, use of inhaled nitric oxide, ICU admission, need for mechanical ventilation, and higher illness severity score. However, the increased LOS and readmission rate trends remained significant even when the authors attempted to control for these factors with propensity score modeling. Interestingly, in this study only 40% of SCD patients with concomitant asthma ...
It is disappointing that the National Institute for Health and Clinical Excellence guidance on managing an acute painful sickle cell episode in hospital did not advocate incentive spirometry as an effective, simple, and cheap (about £14 (€18; $22)) non-pharmacological intervention,1 2 given that up to 54% of inpatients currently receive it as standard care.3 It involves awake patients taking 10 maximal inspirations every two hours.. Randomised data in patients presenting with chest or back pain show an absolute risk reduction of 36.8% (95% confidence interval 12.5% to 61.2%) for pulmonary complications (associated with the development of acute chest syndrome) and reduced hospital admission.4 Inclusion within this high profile guideline would have improved suboptimal or inconsistent use,3 and because the number needed to treat is just 2.7 (1.6 to 8.0) would have immediately benefited patients and budgets. ...
eNOS (endothelin nictric oxide synthase) oxidizes guanidine nitrogen of argenine and generates nitric oxide as free radical and L-citrullline. It mediates cardiovascular homeostasis and involved in the placental abruption and acute chest syndrome.. ...
Definition of acute chest syndrome. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
INCLUSION CRITERIA:. Patients with Hb SS, Sbeta-thal, SD, or SO-Arab. Age greater than or equal to 18 years.. Patient must have had a previous neurologic event (either symptomatic or found by imaging alone).. More than one painful crises per year for the last 2 years, each requiring hospitalization.. A previous acute chest syndrome.. Evidence of renal damage but with a creatinine clearance of greater than 50 percent of normal.. Red cell alloimmunization.. Bilateral retinopathy.. Osteonecrosis of multiple bones.. Unilateral or bilateral leg ulcers.. Patients who have failed a course of hydroxyurea or who have declined to take hydroxyurea.. Able to give informed consent.. No active sickle cell crises or acute chest syndrome.. No active uncontrolled infection.. No hydroxyurea, erythropoietin, and/or arginine butyrate therapy in the previous month.. No patients receiving hypertransfusion therapy.. No current treatment (or within 2 weeks) with hematopoietic growth factors.. No allergy to E. coli ...
Epidemiology of ACS 1 A leading cause of premature death in SCD 6,7 Adult death rate = 4.3% 8 Child death rate = 1.1% 8 50% of SCD patients experience ACS at some point 9 78% associated with VOC 10 Not usually the presenting condition but develops often within hours of hospital admission 10
Respiratory infection is a common precipitant of a sickle crisis but pathogens are rarely detected. In one study an identifiable pathogen was isolated in just over 30% of episodes,1 but this figure is dependent on how hard one looks. The two most common organisms were Chlamydia pneumoniae and Mycoplasma (mostly M pneumoniae and occasionally M hominis). Children suffered more infections with respiratory syncytial virus and parvovirus. Pneumococcus or Staphylococcus were less common, even though most patients are hyposplenic. However, in the reported study patients with chlamydial infections were less likely to be taking prophylactic antibiotics. Many of the cases of infection also had evidence of marrow infarction.1 Since atypical organisms predominate, a strong case can be made for treatment with macrolide antibiotics as the first line treatment when infection is thought to be the cause. However, caution should be exercised as the pattern of infectious agents in the UK may be different and ...
... ™, currently in clinical testing, is an investigational bio-pharmaceutical product that facilitates the transfer of oxygen to oxygen-deprived cells and tissues focusing on treating the comorbidities of sickle cell disease and other disorders caused by anemia or hypoxia/ischemia.. SANGUINATE is the only biological product currently in clinical development for the multiple comorbidities of SCD, and recently received an Orphan Drug Designation from the U.S. FDA. Many of the comorbidities of SCD are caused by a spiraling cycle of sickling, hemolysis and blood vessel inflammation. These comorbidities include vaso-occlusive crisis, acute chest syndrome, leg ulcers and pediatric and adult stroke. By correcting oxygen levels and down-regulating inflammation, SANGUINATE has the promise of effectively treating many of the debilitating, acute comorbidities associated with Sickle Cell Disease.. Phase I studies in healthy volunteers and stable SCD patients have been completed. SANGUINATE is now ...
In recent years, evidence has increased that asthma predisposes to complications of sickle cell disease (SCD), such as pain crises, acute chest syndrome, pulmonary hypertension, and stroke, and is associated with increased mortality. An obstructive pattern of pulmonary function, along with a higher-than-expected prevalence of airway hyper-responsiveness (AHR) when compared to the general population, has led some researchers to suspect that underlying hemolysis may contribute to the development of a pulmonary disease similar to asthma in patients with SCD. While the pathophysiologic mechanism in atopic asthma involves up-regulation of Th2 cytokines, mast cell- and eosinophil-driven inflammation, plus increased activity of inducible nitric oxide synthase (iNOS) and arginase in airway epithelium resulting in obstructive changes and AHR, the exact mechanisms of AHR, obstructive and restrictive lung disease in SCD is unclear. It is known that SCD is associated with a proinflammatory state and an ...
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: Results of a feasibility study (PROACTIVE). British Journal of Haematology, Vol.157, No.5 (Apr 2012):627-636. Article first published online. Lori Styles, Carrie G. Wager, Richard J. Labotka, Kim Smith-Whitley, Alexis A. Thompson, Peter A. Lane, Lillian E. C. McMahon, Robin Miller, Susan D. Roseff, Rathi V. Iyer, Lewis L. Hsu, Oswaldo L. Castro, Kenneth I. Ataga, Onyinye Onyekwere, Maureen Okam, Rita Bellevue, Scott T. Miller.. ...
the primary reason or may accompany it in drug-related lung injury, hereditary hemorrhagic telangiectasia, acute chest syndrome of sickle cell disease, pulmonary alveolar hemorrhage, or widespread infectious processes ...
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: Results of a feasibility study (PROACTIVE). British Journal of Haematology, Vol.157, No.5 (Apr 2012):627-636. Article first published online. Lori Styles, Carrie G. Wager, Richard J. Labotka, Kim Smith-Whitley, Alexis A. Thompson, Peter A. Lane, Lillian E. C. McMahon, Robin Miller, Susan D. Roseff, Rathi V. Iyer, Lewis L. Hsu, Oswaldo L. Castro, Kenneth I. Ataga, Onyinye Onyekwere, Maureen Okam, Rita Bellevue, Scott T. Miller.. ...
[71 Pages Report] Check for Discount on Vaso-Occlusive Crisis Associated With Sickle Cell Disease - Pipeline Review, H2 2017 report by Global Markets Direct. Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline...
Risk, Cell, Syndrome, Treatment, Heparin, Blacks, Thromboembolism, Venous Thromboembolism, Whites, Acute Chest Syndrome, Anemia, Chest, Sickle Cell Anemia, Bleeding, Compression Stockings, Deep Venous Thrombosis, Diagnosis, Disease, Elderly, Injections
Adrienne Johnson, age 5, is admitted to the general pediatric unit. She has sickle cell anemia (hemoglobin SS subtype) and recently was discharged after being hospitalized for acute chest syndrome. According to her mother, Adrienne has been complaining of severe persistent headaches for the past 24 hours. Her primary care . . .. ...
List of 20 causes of Acute chest pain (Acute chest pain symptoms), patient stories, diagnosis questions, and associated symptoms.
List of disease causes of Pulmonary causes of acute chest pain, patient stories, diagnostic guides. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Pulmonary causes of acute chest pain.
The purpose of this study was to relate the 1-year risk of death and development of acute myocardial infarction among diabetics with acute chest pain to whether they had a history of hypertension or not. All patients with a history of diabetes mellitus who, during 21 months, were admitted to the Emergency Room in Sahlgrenska Hospital, G teborg,...
HEART might offer a way to discharge low-risk chest pain patients early and reduce objective cardiac testing, according to findings published March 3. While early discharge with no increase in major adverse events would be a coup, some are not convinced that reducing cardiac testing rates overall is feasible.
Evidence-based information on from hundreds of trustworthy sources for health and social care. Make better, quicker, evidence based decisions. Evidence search provides access to selected and authoritative evidence in health, social care and public health.
Cialis 20Mg Reviews. Abbreviations: FFP, fresh frozen plasma (9 units kg) prior to the operating room shortly after the initial resuscitation,41 these agents are available in 20mg cialis reviews this age group and has the highest reported incidence of vaso-occlusive crises, acute chest syndrome. Harbarth S, Dharan S, Liassine N, et al: Acute compartment syndrome is another clinical symptoms and complications, the emergency department: a review of infants and toddlers as acute syphilitic meningitis.
Sickle cell disease represents a spectrum of inherited hemoglobin disorders. The pathophysiology involves abnormalities not just in red blood cells but also vascular endothelium, white blood cell function, coagulation, and inflammatory response. Known sequelae of sickle cell disease include invasive infections, painful episodes, acute chest syndrome, strokes, and chronic pulmonary hypertension. Preventive strategies that decrease the risk of infection are the routine use of daily antibiotics until five years of age, immunization of children with the 7-valent pneumococcal conjugate vaccine in addition to the 23-valent polysaccharide pneumococcal vaccine, annual influenza vaccination after six months of age, and meningococcal vaccination after two years of age. A significant advance in stroke prevention is the use of transcranial Doppler ultrasonography to identify asymptomatic, at-risk children who should be considered for chronic blood transfusions. Chronic transfusion therapy for primary or secondary
HbSC disease causes symptoms similar to those of homozygous (SS) sickle cell anemia (SCA) such as vaso-occlusive episodes and organ damage [2] with milder severity and less frequency [2,6,13]. Although HbSC has been considered a benign form of SCA in the general population, the incidence of retinitis proliferans, osteonecrosis [6,14], and acute chest syndrome [6] is comparable. In addition, gross hematuria, retinal hemorrhages, and aseptic necrosis of the femoral head are more common in HbSC disease [4]. The life-long hemolytic anemia associated with HbSC disease is milder than the anemia in SS [2] and some patients even have normal hemoglobin levels. This is evidenced by the red cell life-span being approximately two-fold higher in HbSC than in SCA patients (28.9 days vs 15 days, respectively) [15,16]. One study compared the outcome of painful crisis during pregnancy between women with HbSS and HbSC disease and found that 34% of SC patients and 50% of SS patients had at least one pain crisis ...
Induction of Hb F. A large number of epidemiological, clinical, and laboratory observations have converged to support the notion that Hb F administration can ameliorate the clinical severity of SCD. Patients with SCD from the eastern provinces of Saudi Arabia (69) and from India (70) typically have a very mild sickling disorder associated with high levels of Hb F. Furthermore, the CSSCD identified Hb F as a prognostic factor for several sickle cell complications, including painful events (19), acute chest syndrome (16), and death (14). Elegant laboratory studies conducted many years earlier had demonstrated that Hb F interferes with the polymerization of deoxygenated Hb S in vitro (71). Based on all these observations, it was proposed that pharmacological induction of Hb F production may be an effective therapeutic strategy for ameliorating the severity of SCD. When the different globin genes were cloned in the late 1970s (72) and the mechanisms responsible for their regulation were elucidated ...
Acute chest syndrome (ACS) is characterized by chest pain with dyspnea and recent radiologic abnormalities, and is an acute lung complication whose problem is one of etiology. Alveolar hypoventilation linked to infarcts of the thoracic ribs, thoracoabdominal trauma, subdiaphragmatic pain, the administration of analgesics causing respiratory depression, or sleep disturbance, is a frequent cause of ACS. Bronchoalveolar lavage has revealed the frequency of fat embolism following infarcts in the long bones. Pulmonary vascular occlusion, due to thrombosis or emboli, is rare, as are the infectious pneumonia and pulmonary edema. The pathogenetic mechanisms consist of an alteration of the rheological properties of the blood, the existence of an hypercoagulability state, specific interactions between the abnormal sickle cells and the vascular endothelium, and a dysregulation of the vascular reactivity. Research centered around NO biology has led to an expanded understanding of the critical interdependence of NO,
High plasma level of microparticles (MPs) deriving mainly from erythrocytes and platelets has been detected in sickle cell anemia (SCA) patients. Flow cytometry was used to determine the concentration of MPs in two groups of SCA patients exhibiting marked differences in painful vaso-occlusive crisis rates [a non-severe group (n = 17) and a severe group (n = 12)], and in a control group composed of healthy subjects (n = 20). A 3- to 4-fold increase of total MP plasma concentration was detected in SCA patients. Higher platelet-derived MPs concentration was detected in the severe SCA group while erythrocyte-derived MPs concentration was increased in the non-severe SCA patient group only. Our results suggest that plasma concentration of MPs shed by platelets is a biomarker of the vaso-occlusive phenotype-related severity.
OBJECTIVE: To determine the sensitivity and specificity of initial clinical assessment about the diagnosis of acute coronary syndrome (ACS) in patients presenting with acute chest pain by a cardiology resident in the emergency room and assess the 30-day outcome of patients with ACS and non ACS.
Wake Forest Baptist Medical Center doctors have found that using stress cardiac magnetic resonance (CMR) imaging in an Emergency Department observation unit to care for patients with acute chest pain is a win-win - for the patient and the institution.
OBJECTIVES: This study sought to compare the safety, diagnostic efficacy, and efficiency of multi-slice computed tomography (MSCT) with standard diagnostic evaluation of low-risk acute chest pain patients. BACKGROUND: Over 1 million patients have eme
A vaso-occlusive device is introduced in a cavity of a patients vasculature, such as an aneurysm, after which an external energy source, such as a MRI machine is activated to heat the vaso-occlusive device to assist in forming a thrombus or embolism within the treatment site, to release and/or activate a diagnostic or therapeutic agent carried by the vaso-occlusive device, and/or to fuse together portions of the vaso-occlusive device to help stabilize the device in a three-dimensional shape.
HU increases HBF concentrations, and was shown in a landmark NEJM study in 1995 by Charache et. al to reduce morbidity by decreasing the number of painful crises from a median of 4.5 to 2.5 per year. Rates of ACS, blood transfusions also decreased, and time to painful crises also increased in the HU group. An observational follow up of 233 out of 299 of these patients 9 years later by Steinberg et. al from JAMA showed a mortality reduction of 40%. Lastly, one clue that might point to adherence, is that due to its effects, HU should cause an elevated MCV, and so certainly a low MCV might suggest non-adherence. ...
Review question We reviewed the evidence about the effect of giving vitamin D supplements to people with sickle cell disease.. Background Sickle cell disease is an inherited red blood cell disorder affecting millions of people worldwide. In sickle cell disease, the red blood cells become crescent-shaped and hard so that they block small blood vessels resulting in a lack of oxygen supplied to tissues and organs. This blockage causes episodes of pain, short-term and long-term organ damage, acute chest syndrome and stroke. Sickle cell disease can also lead to bone complications in both the short and long term. Pain and musculoskeletal complications are the most common reasons for people with sickle cell disease seeking medical treatment; even though they do not greatly contribute to mortality, they remain an important cause of illness in the short and long term.. Vitamin D deficiency is common in people with sickle cell disease regardless of age and season. Since vitamin D regulates calcium levels ...
METHODS: The BABY HUG database was used to compare inpatient events in subjects receiving hydroxyurea with those receiving placebo. Unit costs were estimated from the 2009 MarketScan Multi-state Medicaid Database for children with sickle cell disease, aged 1 to 3 years. Inpatient costs were based on length of hospital stay, modified by the occurrence of acute chest syndrome, splenic sequestration, or transfusion. Outpatient expenses were based on the schedule required for BABY HUG and a "standard" schedule for 1- to 3-year-olds with sickle cell anemia. ...
A 4-year old male with a history of sickle cell anemia presents to the ED for evaluation of fever of two days duration (Tmax 103.2) and progressively worsening shortness of breath. The patients parents report 48-hour hospitalization 6 months prior secondary to a vaso-occlusive crisis (pain localized to the extremities). ROS is negative for sick contacts. Medications include penicillin prophylaxis. Immunizations are up to date.. VS: HR 127, BP 97/64, RR 32, SpO2 91% on room air.. Physical examination ...
[ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:Hydroxyurea | DROXIA | HYDREA, Synonyms:HYDROXYUREA | HYDROXYCARBAMIDE | DROXIA | HYDREA | SQ 1089 | SQ-1089
The Connecticut Department of Public Health has re-issued a statewide Sickle Cell Disease education campaign that includes three award-winning television and radio spots, to continue to raise awareness of Sickle Cell Disease (SCD).. Sickle Cell Disease (also known as sickle cell anemia) is a group of life-long blood disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent shapes, which then clog capillaries.. "The campaign puts a face on a disease most have heard of but few truly understand," stated DPH Commissioner Dr. J. Robert Galvin. "Sickle Cell Disease often disrupts daily living with illness, pain, trips to emergency departments, stigma and a compromised quality of life. It can lead to a number of medical complications including stroke, acute chest syndrome and organ damage.". The ...
BACKGROUND: Sex-based differences in clinical presentation, pathophysiology, and outcomes of patients with acute chest pain are increasingly being recognized, but are not implemented in guidelines and clinical prediction tools. We evaluated the performance of the HEART score in women versus men, because sex-based differences may exist among the algorithms components: ... read more history, electrocardiogram, age, risk factors, and admission troponin level. METHODS AND RESULTS: The HEART score was retrospectively assessed in 831 women and 1084 men presenting to the emergency department with acute chest pain, assigning patients to the low-, intermediate-, or high-risk category for the occurrence of major adverse cardiac events (MACE) within 6 weeks. MACE, consisting of myocardial infarction, coronary revascularization, and all-cause death, also included events during index visit. Six-week MACE rates were 2 times lower in women than men (10.0% versus 20.8%; P,0.01). Despite similar discriminatory ...
Study Objective: To assess the potential clinical impact of thrombolytic therapy for acute myocardial infarction by determining true-positive and false-positive rates of criteria for eligibility among emergency room patients with acute chest pain.. Design: Prospective multicenter cohort study.. Setting: Emergency rooms of three university and four community hospitals.. Patients: Emergency room patients (7734) with acute chest pain.. Measurements and Main Results: Only 261 (23%) of 1118 patients with acute myocardial infarctions were 75 years of age or younger, presented within 4 hours of the onset of pain, and had emergency room electrocardiograms showing probable acute myocardial infarction; 60 (0.9%) of the 6616 patients without infarction also met these criteria (positive predictive value, 261/321 = 81%; CI, 77% to 86%). The positive predictive value could increase to about 88% (CI, 82% to 93%) if eligibility were based on the official hospital electrocardiogram reading.. Conclusions: Because ...
List of 37 causes for Acute chest muscle strain and Gerd-like chest pain and Severe heartburn after eating, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Results CTP demonstrated a sensitivity of 92% and 89%, specificity of 95% and 99%, positive predictive value (PPV) of 80% and 82% and negative predictive value (NPV) of 98% and 99% for each patient and for each segment, respectively. CTA showed an accuracy of 92%, sensitivity of 70.4%, specificity of 95.5%, PPV 67.8%, and NPV of 95% compared with SPECT-MPI. When CTP findings were added to CTA the PPV improved from 67% to 90.1%. ...
TY - JOUR. T1 - Effects of hydroxyurea treatment for patients with hemoglobin SC disease. AU - Luchtman-Jones, Lori. AU - Pressel, Sara. AU - Hilliard, Lee. AU - Brown, R. Clark. AU - Smith, Mary G.. AU - Thompson, Alexis A.. AU - Lee, Margaret T.. AU - Rothman, Jennifer. AU - Rogers, Zora R.. AU - Owen, William. AU - Imran, Hamayun. AU - Thornburg, Courtney. AU - Kwiatkowski, Janet L.. AU - Aygun, Banu. AU - Nelson, Stephen. AU - Roberts, Carla. AU - Gauger, Cynthia. AU - Piccone, Connie. AU - Kalfa, Theodosia. AU - Alvarez, Ofelia. AU - Hassell, Kathryn. AU - Davis, Barry R.. AU - Ware, Russell E.. PY - 2016/2/1. Y1 - 2016/2/1. N2 - Although hemoglobin SC (HbSC) disease is usually considered less severe than sickle cell anemia (SCA), which includes HbSS and HbS/β0-thalassemia genotypes, many patients with HbSC experience severe disease complications, including vaso-occlusive pain, acute chest syndrome, avascular necrosis, retinopathy, and poor quality of life. Fully 20 years after the ...
Background. Hemoglobin SC disease is one of the most frequent hemoglobinopathy. Surprisingly, few studies were dedicated to this disease, currently considered as a mild variant of homozygous sickle cell disease. The aim of this study was to update our knowledge about hemoglobin SC disease. Design and Methods. We conducted this study in a monocentric series of 179 patients. Clinical and biological data were collected, with a special concern for the assessment of pulmonary arterial hypertension and nephropathy. Results. Hemoglobin SC diagnosis was delayed and performed in adulthood in 29% of cases. Hospitalized painful vasoocclusive crisis, acute chest syndrome and priapism had a prevalence of 36%, 20% and 20% respectively. The most common chronic organ complications were retinopathy and sensorineural otologic disorders occurring in 70% and 29% of cases. Indeed, prevalence of complications reported in homozygous sickle cell disease such as nephropathy, suspicion of pulmonary hypertension, strokes ...
Buy Hydroxycarbamide (hydroxyurea) 500mg online without prescription in USA, Canada, Australia, UK and Europe. Fast order delivery. Worldwide shipping. FDA approved RX online pharmacy.
Grani, C; Senn, O; Bischof, M; Cippa, P E; Hauffe, T; Zimmerli, L; Battegay, E; Franzen, D (2015). Diagnostic performance of reproducible chest wall tenderness to rule out acute coronary syndrome in acute chest pain: a prospective diagnostic study. BMJ Open, 5(1):e007442. ...
There are over 18,000 hospitalizations and 75,000 hospitalization days annually for children suffering vaso-occlusive crises secondary to sickle cell disease. T...
This case report describes cardiac manifestations in a female patient with Churg-Strauss syndrome (CSS). Cardiac magnetic resonance imaging (CMRI) is the only imaging modality able to depict cardiac involvement with endomyocardial fibrosis, myocardia
Nitroglycerin is a type of drug that relaxes (dilates) blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload. "Nitro" is used to treat acute chest pain (angina), in which case it is prescribed as quick-dissolving pills to be placed under the tongue when needed. When the blood vessels dilate, blood flow to the tissues increases. This can relieve chest pain.. ...
Find out more about enrolling in GlycoMimetics Phase 3 trial for rivipansel for the treatment of vaso-occlusive crisis in sickle cell disease patients.
Background: Sickle cell disease (SCD) is a genetic disorder in which deoxygenation produces polymerization of mutated hemoglobin S (HbS) and triggers the downstream effects of red blood cell deformation (sickling), hemolysis, vaso-occlusion and inflammation. Injury from SCD starts in infancy and accumulates over a lifetime causing significant end-organ damage and ischemic tissue injury, leading to fatigue, pain (vaso-occlusive crisis) and other clinical complications that are under-recognized, under-treated, and associated with early death. GBT440 is an oral, once-daily therapy that modulates hemoglobin affinity for oxygen, thereby inhibiting hemoglobin polymerization. GBT440-007 is a Phase 2a study designed to assess the safety, pharmacokinetics (PK) and efficacy of GBT440 in pediatric SCD patients (HbSS or HbSβ0 thalassemia). This abstract reports the first evaluation of multiple doses of GBT440 in adolescents (12 to 17 years) with SCD. Methods: This ongoing study is being conducted in 2 ...
With ,8 million emergency department (ED) visits annually in the United States and a reported 2% of patients discharged from the ED with a missed acute coronary syndrome, the optimal management of acute chest pain in the ED is a dilemma faced by many clinicians (1). Risk stratification on the basis of the initial history, physical examination, electrocardiogram, and troponin measurement is essential early in the triage process. For patients with low to intermediate risk for short-term death and myocardial infarction (MI), the evaluation is focused on identifying those who can be safely discharged from the ED after an observation period, with or without a noninvasive study to evaluate for ischemia (stress test) or coronary artery obstruction (coronary computed tomography angiography [CCTA]). With the advent of high-sensitivity troponins (hsTn), the ability to rule out MI in the ED has improved (2). Previous protocols utilized creatine kinase myocardial band or regular troponin. Therefore, ...
Emphysematous gastritis secondary to vaso-occlusive disease is a surgical emergency. It is a rare but severe form of widespread phlegmonous gastritis commonly encountered in corrosive ingestion, alcohol abuse and rarely with infections. The clinical presentation is diagnostic with supportive information from contrast-enhanced computed tomography (CECT) of the abdomen and gastroduodenoscopy. Here we describe a case of emphysematous gastritis with spontaneous vaso-occlusive disease that was successfully managed without surgery.. ...
Sickle cell disease (SCD) is a genetic disorder that is characterized by recurrent episodes of vaso-occlusive crisis (VOC) from the sickling behavior of red blood cells. Currently, no technique can distinguish the cause or predict the occurrence of a crisis accurately and reliably. One area which has rarely been studied in SCD patients is their autonomic nervous system (ANS). Since the ANS is responsible for the moment-to-moment control of the vascular tone, we hypothesized that the ANS plays an important role in the initiation of their VOC. Computational techniques, including spectral analysis of HRV and a model which characterizes the dynamics of baroreflex and respiratory-cardiac coupling, were used to assess cardiovascular autonomic control in SCD patients and normal control (CTL) subjects. These analysis techniques were applied to responses elicited from the subjects during the application of non-invasive and easily reproducible physiological interventions, such as transient-controlled ...
Sickle cell disease (SCD) is a genetic disorder that is characterized by recurrent episodes of vaso-occlusive crisis (VOC) from the sickling behavior of red blood cells. Currently, no technique can distinguish the cause or predict the occurrence of a crisis accurately and reliably. One area which has rarely been studied in SCD patients is their autonomic nervous system (ANS). Since the ANS is responsible for the moment-to-moment control of the vascular tone, we hypothesized that the ANS plays an important role in the initiation of their VOC. Computational techniques, including spectral analysis of HRV and a model which characterizes the dynamics of baroreflex and respiratory-cardiac coupling, were used to assess cardiovascular autonomic control in SCD patients and normal control (CTL) subjects. These analysis techniques were applied to responses elicited from the subjects during the application of non-invasive and easily reproducible physiological interventions, such as transient-controlled ...
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What Is Sickle Cell Disease? The term sickle cell disease (SCD) describes a group of inherited red blood cell disorders. People with SCD have abnormal hemo
[105 Pages Report] Check for Discount on Sickle Cell Disease - Market Insights, Epidemiology and Market Forecast - 2025 report by Delve Insight. DelveInsight s Sickle Cell Disease (SCD) Market Insights, Epidemiology and...
Sickle cell disease (SCD) is characterized by a marked heterogeneity in clinical and hematologic severity, with bone and joint problems being the most common manifestations. Pain caused by vaso-occlusive episodes may occur as often as every week, or
Compounds, compositions and methods are provided for treatment of sickle cell disease or a complication associated therewith, or graft versus host disease, in an individual. More specifically, the use of particular glycomimetics for the treatment is described.
Care guide for Sickle Cell Disease In Children (Discharge Care). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Learn more about Screening for Sickle Cell Disease at Grand Strand Medical Center Main Page Risk Factors ...
Learn more about Medications for Sickle Cell Disease at Sky Ridge Medical Center Main Page Risk Factors ...
Sickle cell disease has been neglected by scientists and funders, but researchers say now is the time for a moonshot to find a cure.
This Sickle cell disease association of america is a charitable association with the only real intent for assisting exploration, training and financin...
Non-invasive coronary CT angiography (CTA) is more cost-effective than current tests for diagnosing women with low risk of a heart attack who come to the emergency room with acute chest pain, according to a recent study.
Chronic inflammation with oxidative stress emerged as an important pathogenic mechanism in sickle cell disease (SCD) [1-3]. SCD is primarily a disorder of RBCs, which are a significant source of free radicals in biological systems [4]. Oxidative stress may thus contribute to the abnormalities that underlie the clinical course of SCD [4]. Oxidative stress is one of the factors that modulate the phenotypic expression of SCD [5]. Oxygen has the ability to form highly reactive metabolites such as superoxide anion radical (O2 −2), hydrogen peroxide (H2O2), and hydroxyl radical (•OH). These reduced metabolites of oxygen are referred to as "reactive oxygen species ROS" [6]. Oxidative stress can damage specific molecular targets (lipids, proteins, carbohydrates etc.), resulting in cell dysfunction and/or death. Oxidative stress level increases during vaso-occlusive crises and acute chest pain [7]. Oxidative stress is not only linked to chronic inflammation, it also contributes to endothelial ...
Early Signs and Symptoms If a person has sickle cell disease (SCD), it is present at birth. But most infants do not have any problems from the disease until...
Learn more about Symptoms of Sickle Cell Disease at Doctors Hospital of Augusta Main Page Risk Factors Symptoms ...
Learn more about Screening for Sickle Cell Disease at Portsmouth Regional Hospital Main Page Risk Factors ...
Thanks to advancements in early diagnosis and treatment, most kids born with sickle cell disease grow up to live relatively healthy and productive lives.
Thanks to advancements in early diagnosis and treatment, most kids born with sickle cell disease grow up to live active, healthy, and productive lives.
A key trigger for producing normal red blood cells that could lead to new treatments for those with sickle cell disease has been revealed by researchers.
A team of researchers at the Stanford University School of Medicine has used a gene-editing tool known as CRISPR to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward ...
... is a blood disorder that causes red blood cells to change shape and cause problems. Find out more in this article for teens.
Learn more about Sickle Cell Disease at Regional Medical Center Bayonet Point Uses Principal Proposed Natural Treatments Zinc ...
A 22-year-old male with a history of sickle cell disease is brought to the ED by police after he was found altered and naked outside on a rainy night.

Sickle Cell Anemia - Causes , Symptoms , Treatment of Sickle Cell AnemiaSickle Cell Anemia - Causes , Symptoms , Treatment of Sickle Cell Anemia

Additional treatments include : antibiotics for infection; partial exchange transfusion for acute chest syndrome; potentially ... In infants who have not been screened, an episode of hand-foot syndrome may be the first sign that your child has sickle cell ... The doctor will ask you about a history of painful crises, neurological problems, chest pain and history of infections. He or ... If acute painful crises occur or at the first sign of any infection. ...
more infohttp://free-health-care.com/general_problems/sickle%20cell%20anemia.htm

Effects of hydroxyurea treatment for patients with hemoglobin SC disease<...Effects of hydroxyurea treatment for patients with hemoglobin SC disease<...

... acute chest syndrome, avascular necrosis, retinopathy, and poor quality of life. Fully 20 years after the clinical and ... acute chest syndrome, avascular necrosis, retinopathy, and poor quality of life. Fully 20 years after the clinical and ... acute chest syndrome, avascular necrosis, retinopathy, and poor quality of life. Fully 20 years after the clinical and ... acute chest syndrome, avascular necrosis, retinopathy, and poor quality of life. Fully 20 years after the clinical and ...
more infohttps://utsouthwestern.pure.elsevier.com/en/publications/effects-of-hydroxyurea-treatment-for-patients-with-hemoglobin-sc-

Treatment of Sickle Cell Anemia, Sickle Cell Disease, Sickle Cell Anemia Definition, Causes, Risk Factors, Symptoms, Diagnosis ...Treatment of Sickle Cell Anemia, Sickle Cell Disease, Sickle Cell Anemia Definition, Causes, Risk Factors, Symptoms, Diagnosis ...

Acute chest syndrome. This life-threatening complication of sickle cell anemia causes chest pain, fever and difficulty ... Acute chest syndrome is similar to pneumonia, but is caused by a lung infection or trapped sickle cells in the blood vessels of ... It may be helpful if you have acute chest syndrome or a sickle cell crisis. ... Hand-foot syndrome. Swollen hands and feet are often the first signs of sickle cell anemia in babies. The swelling is caused by ...
more infohttp://www.knowyourdisease.com/treatment-of-sickle-cell-anemia.html

Dual Case Report of Hemoglobin SC Disease in Pregnancy
 | MedCraveDual Case Report of Hemoglobin SC Disease in Pregnancy | MedCrave

Keywords: Acute chest syndrome (ACS); Acute Joint crisis; HbSC; Hemoglobin SC disease; Hyperviscosity; Phlebotomy; Pregnancy; ... Acute chest syndrome was seen in both HbSS and HbSC, 9.8% and 4.6% (p=0.3), respectively. There were no significant differences ... and acute chest syndrome [6] is comparable. In addition, gross hematuria, retinal hemorrhages, and aseptic necrosis of the ... The most common areas for pain are the lower back, chest, femoral shaft and hip joints, ribs, knees, abdomen, and head. At ...
more infohttp://googlescholar.medcraveonline.com/scholars/article_fulltext/3539

Vitamin D supplementation for sickle cell disease | CochraneVitamin D supplementation for sickle cell disease | Cochrane

Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications ( ... acute chest syndrome, acute exacerbation of asthma and respiratory infections; and the safety of vitamin D supplementation in ... This blockage causes episodes of pain, short-term and long-term organ damage, acute chest syndrome and stroke. Sickle cell ... at least 30 days from blood transfusion and at least 14 days from any acute sickle complication. The quality of evidence for ...
more infohttp://www.cochrane.org/CD010858/CF_vitamin-d-supplementation-sickle-cell-disease

Sickle Cell Anemia with Splenic SequestrationSickle Cell Anemia with Splenic Sequestration

Acute Chest Syndrome Acute Vaso-Occlusive Episode in Sickle Cell Anemia Alpha Thalassemia Beta Thalassemia Cerebrovascular ... Pediatric Abdominal Pain Leukemia Acute Chest Syndrome Family Practice Notebook Updates 2016 Thrombocytopenia Transient Red ... Post-acute stabilization care (following Blood Transfusions). *Observe for occlusive complications from transfusion ( ... Acute splenic enlargement (especially in under age 5 years, before auto-infarction) ...
more infohttp://www.fpnotebook.com/HemeOnc/Hemoglobin/ScklClAnmWthSplncSqstrtn.htm

Sickle Cell Anemia with Splenic SequestrationSickle Cell Anemia with Splenic Sequestration

Acute Vaso-Occlusive Episode in Sickle Cell Anemia * Acute Chest Syndrome * Hand Foot Syndrome in Sickle Cell Anemia ... Post-acute stabilization care (following Blood Transfusions). *Observe for occlusive complications from transfusion ( ... Acute splenic enlargement (especially in under age 5 years, before auto-infarction) ... Rapidly progressive course with significant risk of decompensation secondary to acute Anemia ...
more infohttp://www.fpnotebook.com/legacy/HemeOnc/Hemoglobin/ScklClAnmWthSplncSqstrtn.htm

Acute chest syndrome definition | Drugs.comAcute chest syndrome definition | Drugs.com

Definition of acute chest syndrome. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... acute chest syndrome. Definition: a syndrome occurring in association with sickle cell disease defined by a new infiltrate on ... chest radiograph; associated with one or more new symptoms: fever, cough, sputum production, dyspnea, or hypoxia. It occurs ...
more infohttps://www.drugs.com/dict/acute-chest-syndrome.html

sPLA2 in EBC During Acute Chest Syndrome - Full Text View - ClinicalTrials.govsPLA2 in EBC During Acute Chest Syndrome - Full Text View - ClinicalTrials.gov

Sickle Cell Patients with Acute Chest Syndrome Sickle cell patients with active acute chest syndrome (ACS) from which samples ... Syndrome. Anemia, Sickle Cell. Acute Chest Syndrome. Disease. Pathologic Processes. Anemia, Hemolytic, Congenital. Anemia, ... sPLA2 in EBC During Acute Chest Syndrome. The safety and scientific validity of this study is the responsibility of the study ... Definition of acute chest syndrome to be used: New radiographic pulmonary infiltrate of at least one complete lung segment in ...
more infohttps://clinicaltrials.gov/show/NCT03250585

Sickle Cell Disease: Acute Chest Syndrome - Adventist HealthCareSickle Cell Disease: Acute Chest Syndrome - Adventist HealthCare

Sickle Cell Disease: Acute Chest Syndrome. Topic Overview. Acute chest syndrome is a lung-related complication of sickle cell ... Treatment of acute chest syndrome includes:. *Encouraging deep breathing. This is especially important when a person has chest ... Repeat occurrences of acute chest syndrome can cause lung damage. This condition develops more often in young children but is ... Because a person with acute chest syndrome can deteriorate rapidly, a hospital stay is usually needed. Some cases are mild and ...
more infohttps://www.adventisthealthcare.com/health/library/topic/?id=hw254008

Preventing Acute Chest Syndrome by Transfusion Feasibility Study - Tabular View - ClinicalTrials.govPreventing Acute Chest Syndrome by Transfusion Feasibility Study - Tabular View - ClinicalTrials.gov

Preventing Acute Chest Syndrome by Transfusion Feasibility Study. Official Title ICMJE Preventing Acute Chest Syndrome by ... Acute Chest Syndrome [ Time Frame: Chest x-rays (CXR) were ordered for trial eligibility, as a result of clinical indications, ... Preventing Acute Chest Syndrome by Transfusion Feasibility Study (PROACTIVE). The safety and scientific validity of this study ... Acute chest syndrome (ACS) is similar to severe pneumonia and is a common cause of hospitalizations for people with sickle cell ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT00951808

The Acute Chest Syndrome in Sickle-Cell Disease - Incidence and Risk-Factors | RTIThe Acute Chest Syndrome in Sickle-Cell Disease - Incidence and Risk-Factors | RTI

1994). The Acute Chest Syndrome in Sickle-Cell Disease - Incidence and Risk-Factors. Blood, 84(2), 643-649. ... The Acute Chest Syndrome in Sickle-Cell Disease - Incidence and Risk-Factors. ...
more infohttps://www.rti.org/publication/acute-chest-syndrome-sickle-cell-disease-incidence-and-risk-factors

Sickle Cell Disease: Acute Chest SyndromeSickle Cell Disease: Acute Chest Syndrome

... Skip to the navigation Topic Overview. Acute chest syndrome is a lung-related ... Treatment of acute chest syndrome includes:. *Encouraging deep breathing. This is especially important when a person has chest ... Repeat occurrences of acute chest syndrome can cause lung damage. This condition develops more often in young children but is ... Because a person with acute chest syndrome can deteriorate rapidly, a hospital stay is usually needed. Some cases are mild and ...
more infohttps://www.lancastergeneralhealth.org/Healthwise/Document.aspx?id=hw254008

Acute chest syndrome in sickle cell disease - The Clinical AdvisorAcute chest syndrome in sickle cell disease - The Clinical Advisor

Are you sure your patient has acute chest syndrome? What are the typical findings for this disease?. Acute chest syndrome (ACS ... What are the possible outcomes of acute chest syndrome?. During an ACS, there is an increased risk of posterior reversible ... Are you sure your patient has acute chest syndrome? What are the typical findings for this disease? ... Chest radiography should be performed in patients with fever, shortness of breath, tachypnea, cough, rales or chest pain and of ...
more infohttps://www.clinicaladvisor.com/pediatrics/acute-chest-syndrome-in-sickle-cell-disease/article/624157/

Blood transfusions for treating acute chest syndrome in people with sickle cell disease | CochraneBlood transfusions for treating acute chest syndrome in people with sickle cell disease | Cochrane

People with sickle cell disease may have the acute onset of chest problems which may include fever, this is called acute chest ... Acute chest syndrome is a frequent complication of sickle cell disease, as well as a major cause of morbidity and the greatest ... Blood transfusions for treating acute chest syndrome in people with sickle cell disease. Review question ... Thereore, this unique study did not show how effective blood transfusions might be for treating acute chest syndrome in people ...
more infohttps://www.cochrane.org/CD007843/CF_blood-transfusions-treating-acute-chest-syndrome-people-sickle-cell-disease

Acute chest syndrome - WikipediaAcute chest syndrome - Wikipedia

The Acute Chest Syndrome". Knight-Madden, JM; Hambleton, IR (Aug 2, 2014). "Inhaled bronchodilators for acute chest syndrome in ... The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell ... Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation ... Acute chest syndrome is an indication for exchange transfusion. Bronchodilators may be useful but have not been well studied. ...
more infohttps://en.wikipedia.org/wiki/Acute_chest_syndrome

https://www.thefreelibrary.com/Rare+Case+of+Posterior+Reversible+Leukoencephalopathy+Syndrome...-a0515248247https://www.thefreelibrary.com/Rare+Case+of+Posterior+Reversible+Leukoencephalopathy+Syndrome...-a0515248247

Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome.(Case Report, Case study) by ... APA style: Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome.. (n.d.) >The Free ... MLA style: "Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome.." The Free ... S.v. Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome.." Retrieved Jul 18 2019 ...
more infohttps://www.thefreelibrary.com/Rare+Case+of+Posterior+Reversible+Leukoencephalopathy+Syndrome...-a0515248247

Pulmonary Thromboembolism in a Child with Sickle Cell Hemoglobin D Disease in the Setting of Acute Chest SyndromePulmonary Thromboembolism in a Child with Sickle Cell Hemoglobin D Disease in the Setting of Acute Chest Syndrome

... Hazel ... "Pulmonary Thromboembolism in a Child with Sickle Cell Hemoglobin D Disease in the Setting of Acute Chest Syndrome," Case ...
more infohttps://www.hindawi.com/journals/cripe/2013/875683/cta/

The pulmonary physician in critical care • Illustrative case 6: Acute chest syndrome of sickle cell anaemia | ThoraxThe pulmonary physician in critical care • Illustrative case 6: Acute chest syndrome of sickle cell anaemia | Thorax

acute chest syndrome. New insights into the pathophysiology of acute chest syndrome (ACS) have highlighted potential ... A repeat chest radiograph showed new infiltrates in both lower zones and a diagnosis of acute sickle chest syndrome (ACS) was ... Management of acute chest syndrome. Most adult patients are admitted with vaso-occlusive crises and develop ACS after a few ... Pathophysiology of the acute chest syndrome in sickle cell disease. The genetic defect in sickle cell anaemia causes a ...
more infohttp://thorax.bmj.com/content/58/8/726

Acute chest syndrome | definition of acute chest syndrome by Medical dictionaryAcute chest syndrome | definition of acute chest syndrome by Medical dictionary

What is acute chest syndrome? Meaning of acute chest syndrome medical term. What does acute chest syndrome mean? ... Looking for online definition of acute chest syndrome in the Medical Dictionary? acute chest syndrome explanation free. ... acute chest syndrome. a·cute chest syn·drome. a syndrome occurring in association with sickle cell disease defined by a new ... Acute chest syndrome , definition of acute chest syndrome by Medical dictionary https://medical-dictionary.thefreedictionary. ...
more infohttp://medical-dictionary.thefreedictionary.com/acute+chest+syndrome

Heme oxygenase1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with...Heme oxygenase1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with...

Home » Blog » News » Heme oxygenase1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome ... Heme oxygenase1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with ... This project is supported in part by the NIH Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network ...
more infohttp://www.strokecenter.org/heme-oxygenase1-gene-promoter-polymorphism-is-associated-with-reduced-incidence-of-acute-chest-syndrome-among-children-with-sickle-cell-disease/

Acute chest syndrome in sickle cell diseaseAcute chest syndrome in sickle cell disease

Are you sure your patient has acute chest syndrome? What are the typical findings for this disease?. Acute chest syndrome (ACS ... What are the possible outcomes of acute chest syndrome?. During an ACS, there is an increased risk of posterior reversible ... Are you sure your patient has acute chest syndrome? What are the typical findings for this disease? ... Chest radiography should be performed in patients with fever, shortness of breath, tachypnea, cough, rales or chest pain and of ...
more infohttps://www.pulmonologyadvisor.com/pediatrics/acute-chest-syndrome-in-sickle-cell-disease/article/660872/

Respiratory Failure in Sickle cell anemia; Acute Chest Syndrome - Cancer Therapy AdvisorRespiratory Failure in Sickle cell anemia; Acute Chest Syndrome - Cancer Therapy Advisor

"Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group". New England ... Consider alternative etiologies for acute respiratory failure: acute coronary syndrome, acute heart failure, arrythmia, cardiac ... The National Acute Chest Syndrome Study Group identified 538 patients with 671 episodes of ACS. The following outcomes were ... Vichinsky, E. P., Styles, L. A., Colangelo, L. H., Wright, E. C., Castro, O., Nickerson, B. "Acute chest syndrome in sickle ...
more infohttps://www.cancertherapyadvisor.com/home/decision-support-in-medicine/critical-care-medicine/respiratory-failure-in-sickle-cell-anemia-acute-chest-syndrome/

Inserm - Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell...Inserm - Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell...

Clinical charts were retrospectively reviewed to determine prior acute chest syndrome or vaso-occlusive episodes, and rates of ... a higher steady-state red blood cell disaggregation threshold was associated with previous history of acute chest syndrome in ... the first time that the red blood cell aggregation properties may play a role in the pathophysiology of acute chest syndrome in ... Little is known about the effects of blood rheology on the occurrence of acute chest syndrome and painful vaso-occlusive crises ...
more infohttps://www.hal.inserm.fr/inserm-00849038

emDOCs.net - Emergency Medicine EducationEM@3AM - Acute Chest Syndrome - emDOCs.net - Emergency Medicine EducationemDOCs.net - Emergency Medicine [email protected] - Acute Chest Syndrome - emDOCs.net - Emergency Medicine Education

Answer: Acute Chest Syndrome (ACS)1-3. *Presentation: fever (,38.5°C or 101.3°F), tachypnea, cough, +/-chest pain, +/- wheezing ... Acute chest syndrome is the leading cause of death in sickle cell patients in the U.S. (12% mortality).2 ... Traill L and Barton M. Focus On: Acute Chest Syndrome - The Critical Cough. American College of Emergency Physicians Clinical ... Causes and outcomes of the acute chest syndrome in sickle cell disease. N Engl J Med. 2000; 342:1855-1865. ...
more infohttp://www.emdocs.net/em3am-acute-chest-syndrome/
  • Sickle cell patients with active acute chest syndrome (ACS) from which samples of EBC and plasma will be collected during acute illness within 48 hours of admission with or diagnosis of ACS (Time point 1) in 3 sessions each 1 hour apart (Time point 1a, 1b, and 1c), and 2 weeks after discharge when have returned to steady-state (Time point 2). (clinicaltrials.gov)
  • Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation leads to further sickling of red cells, thus exacerbating pulmonary and systemic hypoxemia, sickling, and vaso-occlusion. (wikipedia.org)
  • Repeat occurrences of acute chest syndrome can cause lung damage. (adventisthealthcare.com)
  • Patients who were treated with Endari over a 48-week period experienced fewer crisis episodes compared to patients who received a placebo, fewer hospitalizations for sickle cell pain, fewer days in the hospital, and ewer occurrences of acute chest syndrome , a life-threatening complication of sickle cell disease. (thefreedictionary.com)
  • 11 days) and fewer occurrences of potentially life-threatening acute chest syndrome (8. (thefreedictionary.com)
  • 1) " Acute Chest Syndrome " from UMEM Educational Pearls. (blogspot.com)
  • The misshapen cells clog smaller blood vessels, resulting in excruciating pain and putting patients at an increased risk of infection, acute chest syndrome and stroke. (thefreedictionary.com)
  • Pulmonary infarction-in situ sickling, fat embolism syndrome, hypoventilation secondary to rib/sternal bone infarction, hypoventilation secondary to narcotic administration, pulmonary oedema induced by narcotics or fluid overload. (thefreedictionary.com)
  • Acute chest syndrome is an indication for exchange transfusion. (wikipedia.org)
  • After two weeks, the patient had a sudden onset of hypertension secondary to acute kidney injury (creatinine: 5.19mg/dL, blood urine nitrogen: 57 mg/dL), with a blood pressure reading of 212/96, and was found to have witnessed generalized tonic-clonic seizure lasting 1 minute. (thefreelibrary.com)
  • For the evaluation of suspected acute coronary syndromes (ACS) in the ED, consensus guidelines recommend obtaining basic history, physical examination, electrocardiogram (ECG), cardiac biomarkers, and chest radiography. (ebmedicine.net)
  • Computed tomography of the chest is important to identify progressive disease. (clinicaladvisor.com)
  • Initial labs indicated hemoglobin of 8.0 and hematocrit of 21.1, as well as reticulocyte count of 9.58% and immature reticulocyte fraction of 42.2%, consistent with acute chest syndrome (ACS) secondary to sickle cell disease. (thefreelibrary.com)
  • Hazel Villanueva, Sandeepkumar Kuril, Jennifer Krajewski, and Aziza Sedrak, "Pulmonary Thromboembolism in a Child with Sickle Cell Hemoglobin D Disease in the Setting of Acute Chest Syndrome," Case Reports in Pediatrics , vol. 2013, Article ID 875683, 3 pages, 2013. (hindawi.com)
  • Acute Chest Syndrome/Sickle Cell Disease is a topic covered in the Johns Hopkins ABX Guide . (unboundmedicine.com)
  • Pediatrics Central , peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540649/all/Acute_Chest_Syndrome_Sickle_Cell_Disease. (unboundmedicine.com)
  • Mary Cataletto from Stony Brook University's school of medicine said, "Management of acute chest syndrome is a major challenge for physicians and other healthcare providers caring for children with sickle cell disease . (femaleadda.com)
  • Progressive restrictive lung disease related to recurrent episodes of acute chest syndrome may develop with advancing age [ 3 ]. (biomedcentral.com)
  • Phospholipase A2 levels in acute chest syndrome of sickle cell disease" (PDF). (wikipedia.org)
  • Do steroids have a role in treatment of Acute Chest Syndrome? (blogspot.com)
  • Because a person with acute chest syndrome can deteriorate rapidly, a hospital stay is usually needed. (adventisthealthcare.com)
  • This project is supported in part by the NIH Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network, and NINDS grant 3P50NS055977 to Washington University in St. Louis School of Medicine and UT Southwestern Medical Center. (strokecenter.org)
  • Monitoring the amount of fluids being consumed, because fluids may build up in the lungs ( pulmonary edema ) during acute chest syndrome. (adventisthealthcare.com)
  • It is not only important to know how to recognize and treat an acute episode but to be able to implement long term management strategies to try and prevent future episodes. (femaleadda.com)
  • If the patient has a concomitant condition for which steroids would usually be indicated, particularly acute asthma exacerbation, then their cautious use is likely warranted. (blogspot.com)