Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Candidiasis: Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)Candida: A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)Drug Resistance, Fungal: The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.Candida albicans: A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.TriazolesAmphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.Candidiasis, Oral: Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Fungemia: The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.Azoles: Five membered rings containing a NITROGEN atom.Candida glabrata: A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.Meningitis, Cryptococcal: Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.MycosesCryptococcus neoformans: A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella neoformans.Candida tropicalis: A species of MITOSPORIC FUNGI that is a major cause of SEPTICEMIA and disseminated CANDIDIASIS, especially in patients with LYMPHOMA; LEUKEMIA; and DIABETES MELLITUS. It is also found as part of the normal human mucocutaneous flora.Ketoconazole: Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.Sterol 14-Demethylase: An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.Cryptococcosis: Infection with a fungus of the species CRYPTOCOCCUS NEOFORMANS.Echinocandins: Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.Ergosterol: A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.Pharyngeal Diseases: Pathological processes involving the PHARYNX.Drug Resistance, Multiple, Fungal: The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.Meningitis, Fungal: Meningitis caused by fungal agents which may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.Candidemia: A form of invasive candidiasis where species of CANDIDA are present in the blood.AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.Oropharynx: The middle portion of the pharynx that lies posterior to the mouth, inferior to the SOFT PALATE, and superior to the base of the tongue and EPIGLOTTIS. It has a digestive function as food passes from the mouth into the oropharynx before entering ESOPHAGUS.Trichosporon: A mitosporic fungal genus causing opportunistic infections, endocarditis, fungemia, a hypersensitivity pneumonitis (see TRICHOSPORONOSIS) and white PIEDRA.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Candidiasis, Vulvovaginal: Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.Lipopeptides: Compounds consisting of a short peptide chain conjugated with an acyl chain.Esophageal Diseases: Pathological processes in the ESOPHAGUS.Candidiasis, Invasive: An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.14-alpha Demethylase Inhibitors: Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.Cryptococcus gattii: A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella bacillispora.Mycological Typing Techniques: Procedures for identifying types and strains of fungi.Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.Peptides, Cyclic: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).Cryptococcus: A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.Coccidioidomycosis: Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN.Clotrimazole: An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.Chemoprevention: The use of chemical compounds to prevent the development of a specific disease.Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.Fungal Proteins: Proteins found in any species of fungus.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Colony Count, Microbial: Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.Aspergillosis: Infections with fungi of the genus ASPERGILLUS.Fungi: A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.Histoplasmosis: Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. It is worldwide in distribution and particularly common in the midwestern United States. (From Dorland, 27th ed)Sterols: Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)DNA, Fungal: Deoxyribonucleic acid that makes up the genetic material of fungi.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Blastomycosis: A fungal infection that may appear in two forms: 1, a primary lesion characterized by the formation of a small cutaneous nodule and small nodules along the lymphatics that may heal within several months; and 2, chronic granulomatous lesions characterized by thick crusts, warty growths, and unusual vascularity and infection in the middle or upper lobes of the lung.Eye Infections, Fungal: Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.Area Under Curve: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
... especially in synergistic activity with amphotericin B and additive activity with fluconazole. Echinocandins are fungistatic ... and fungicidal activity against most Candida spp., including strains that are fluconazole-resistant. In vitro and mouse models ... The chains act as anchors on the fungal cell membrane to help facilitate antifungal activity. Due to their limited oral ... The semisynthetic pneumocandin analogs of echinocandins were later found to have the same kind of antifungal activity, but low ...
Activity was enhanced with fluconazole co-delivery. Antiparasitic activity against Leishmania donovani. Antibacterial activity ... "The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a ... "The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a ... This activity thought to be mediated via inhibition of the chaperone protein BiP. Antimicrobial activity is often not against ...
This specific drug undergoes slow chemical hydrolysis to an open-ring peptide which lacks antifungal activity. The half-life of ... Including 315 Isolates Resistant to Fluconazole". J Clin Microbiol. 43 (11): 5425-7. doi:10.1128/JCM.43.11.5425-5427.2005. PMC ... Pfaller MA, Boyken L, Hollis RJ, Messer SA, Tendolkar S, Diekema DJ (2005). "In Vitro Activities of Anidulafungin against More ... Glucan synthase is not present in mammalian cells, so it is an attractive target for antifungal activity. Anidulafungin is ...
Voriconazole is a new generation from fluconazole with a higher potential of broad spectrum activity. All of the mentioned ... fluconazole is water soluble, ready to be taken orally. C. tropicalis can rapidly develop resistance towards fluconazole ... Once decided on the medium, need to add 8 ug of fluconazole per mL to limit bacterial growth and contamination. When the medium ... These types of agents will function to lower candida species' phospholipases activities. Flucytosine ( 5FC) is another type of ...
"Fungicidal Activity of Fluconazole against Candida albicans in a Synthetic Vagina-Simulative Medium". Antimicrob. Agents ... C. albicans can develop resistance to fluconazole, this being more of an issue in those with HIV/AIDS who are often treated ... By mouth or intravenous fluconazole, itraconazole, or amphotericin B may be used if these do not work. A number of topical ... Intravenous fluconazole or an intravenous echinocandin such as caspofungin are commonly used to treat immunocompromised or ...
This extract can increase the antifungal activity of Fluconazole against resistant Aspergillus species. Matin A; Khan MA; ... "The antifungal activity of Sarcococca saligna ethanol extract and its combination effect with fluconazole against different ... saligna indicate antibacterial activity against several human pathogenic bacteria and antifungal activity against Aspergillus ... In addition ethanolic extract of S. saligna has steroidal alkaloids which can demonstrate cholinesterase inhibitory activity. ...
Antifungal activity is observed for sequential incubation of Candida with lactoferrin and then with fluconazole, but not vice ... The loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity is observed in ... However, a combination of lactoferrin with fluconazole can act against fluconazole-resistant strains of Candida albicans as ... "Synergistic activity of the N-terminal peptide of human lactoferrin and fluconazole against Candida species". Antimicrob. ...
Miconazole has shown the best in vivo activity; however, itraconazole, fluconazole, ketoconazole and voriconazole have also ... Wiederhold, NP; Lewis, RE (June 2009). "Antifungal activity against Scedosporium species and novel assays to assess antifungal ...
"In vitro activity of essential oils extracted from condiments against fluconazole-resistant and -sensitive Candida glabrata". ... Estrogenic and antiandrogenic activity have been reported by in vitro study of tea tree oil and lavender essential oils. Case ... Antibacterial activity of volatile oils of some spices". Phytotherapy Research. 16 (7): 680-2. doi:10.1002/ptr.951. PMID ... "Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida". BMC ...
Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In ... Fluconazole is a fungistatic antifungal medication that is administered orally or intravenously. It is used to treat a variety ... particular, it is active against Aspergillus, which fluconazole is not. The mechanism of action of itraconazole is the same as ...
... has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In ... Itraconazole also showed activity in a phase II trial in men with non-small cell lung cancer when it was combined with the ... These distinct activities are unrelated to inhibition of the cytochrome P450 lanosterol 14 alpha-demethylase and the exact ... Functionally, the antiangiogenic activity of itraconazole has been shown to be linked to inhibition of glycosylation, VEGFR2 ...
In vitro activity of amphotericin B, fluconazole, itraconazole, voriconazole, ravuconazole and terbinafine against the clinical ... Cellulase activities of Ulocladium chartarum were found to be influenced by the mode of incubation as well as by the age of the ...
Later, triazoles fluconazole and itraconazole, with a broader spectrum of antifungal activity and improved safety profile were ... In order to overcome limitations such as sub-optimal spectra of activity, drug-drug interactions, toxicity, development of ...
"The antifungal activity of Sarcococca saligna ethanol extract and its combination effect with fluconazole against different ... Other heavy metal cations such as Hg2+ and Pb2+ have antimicrobial activities, but can be toxic. Traditional herbalists used ... Many of these plants have been investigated scientifically for antimicrobial activity, and some plant products have been shown ... Many essential oils included in herbal pharmacopoeias are claimed to possess antimicrobial activity, with the oils of bay, ...
In Africa, oral fluconazole at a rate of 200 mg daily is often used. However, this does not result in cure, because it merely ... but prospective studies from Uganda and Malawi reported that higher doses of 1200 mg per day have more fungicidal activity. The ... 2006). "Outcome of AIDS-associated cryptococcal meningitis initially treated with 200 mg/day or 400 mg/day of fluconazole". BMC ... This should then be followed by oral fluconazole 400-800 mg daily for ten weeks and then 200 mg daily for at least one year and ...
The molecule acts by inhibiting Trypanosoma cruzi sterol 14α-desmethylase activity in vitro. It exhibits no toxicity in mouse ... cells and unlike the related compounds posaconazole and fluconazole, increasing the dose is not required to maintain anti- ... parasitic activity.[non-primary source needed] According to the researchers, "VNI cures the acute and chronic forms of Chagas ...
Fluconazole is commonly used as it has been shown to have synergistic effects against naegleria when used with amphotericin in- ... It only has variable activity in-vitro and it has strong effects on the therapeutic levels of other antimicrobials used by ... such as fluconazole, miconazole, rifampicin and azithromycin. They have shown limited success only when administered early in ... fowleri into the nose during activities such as swimming, bathing, or nasal irrigation. The amoeba follows the olfactory nerve ...
In at least the case of fluconazole, antifungal resistance due to C5SD inactivation is dependent on the activity of the ... C5SD activity has been demonstrated in microsomes from rat tissue, implying that rat enzyme localizes to the endoplasmic ... In at least one patient, a deficiency in C-5 sterol desaturase activity (termed lathosterolosis) was associated with multiple ... Ishibashi Teruo (2002). "Supernatant protein relevant to the activity of membrane-bound enzymes: studies on lathosterol 5- ...
Other biological activities of the imidazole pharmacophore relate to the downregulation of intracellular Ca2+ and K+ fluxes, ... For comparison, another group of azoles is the triazoles, which includes fluconazole, itraconazole, and voriconazole. The ... It is present in the anticancer medication mercaptopurine, which combats leukemia by interfering with DNA activities. A number ... "Effect of anti-fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase". Br. J. Pharmacol. 111 ...
Pandey AV, Kempná P, Hofer G, Mullis PE, Flück CE (October 2007). "Modulation of human CYP19A1 activity by mutant NADPH P450 ... However, reports of ABS in some offsprings of mothers who were treated with fluconazole, an antifungal agent which interferes ... Nicolo C, Flück CE, Mullis PE, Pandey AV (June 2010). "Restoration of mutant cytochrome P450 reductase activity by external ... Flück CE, Mullis PE, Pandey AV (October 2010). "Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 ...
The minimum inhibitory concentration (MIC) of fluconazole for E. jeanselmei is very high, flucytosine and miconazole also have ... Novel drugs such as echinocandin and caspofungin also have favorable antifungal activity against Exophiala jeanselmei isolates ...
Fluconazole's spectrum of activity includes most Candida species (but not Candida krusei or Candida glabrata), Cryptococcus ... concomitant administration of fluconazole and quinidine, especially when fluconazole is administered in high dosages; take ... Fluconazole is available as a generic medication. The wholesale cost in the developing world is about 0.05 to 0.10 USD per day ... Fluconazole was patented in 1981 and came into commercial use in 1988. It is on the World Health Organization's List of ...
It has been investigated for use in patients after liver transplantation, but fluconazole was found to be much more effective ... Liposomal nystatin is not commercially available, but investigational use has shown greater in vitro activity than colloidal ... CS1 maint: Uses authors parameter (link) Hammond, S.M. (1977). "Biological activity of polyene antibiotics". Progress in ... although fluconazole is the preferred treatment. It has been found to reduce the rate of invasive fungal infections and also ...
The activity of ramelteon at the MT1 and MT2 receptors is believed to contribute to its sleep-promoting properties, as these ... and strong CYP2C9 inhibitors such as fluconazole. Efficacy may be reduced when ramelteon is used in combination with potent CYP ... Ramelteon also does not interfere with the activity of a number of selected enzymes in a standard panel. The major metabolite ... Similar to ramelteon, M-II does not interfere with the activity of a number of endogenous enzymes. Discovery and development of ...
... exerts its activity by interacting with lipids, inhibiting cytochrome c oxidase and causing apoptosis-like cell ... fluconazole, flucytosine, and azithromycin. In 2013, there were reports of failure of miltefosine in the treatment of ... Initial in vivo investigation on the antineoplastic activity showed positive result, but then only at high dosage and at high ... Croft, S.L.; Neal, R.A.; Pendergast, W.; Chan, J.H. (1987). "The activity of alkyl phosphorylcholines and related derivatives ...
There is some evidence that domperidone has antiemetic activity.[13] It is recommended in the Canadian Headache Society's ... CYP3A4 inhibitors (e.g., triazole antifungal medications such as ketoconazole, itraconazole, fluconazole; macrolide antibiotics ...
Fluconazole has excellent CNS penetration and may be considered as an alternative to amphotericin B for the treatment of CNS ... Although animal data suggests that voriconazole may have activity against blastomycosis, there are no human clinical studies ... Ketoconazole or fluconazole 400-800 mg/day for at least 6 months is effective alternative therapy for non-life-threatening ... Fluconazole, itraconazole, and ketoconazole are all used as chronic suppressive therapy; however, given the higher relapse rate ...
Application of antimicrobial therapy in Gram-negative activity; Utilization of kanamycin and gentamicin as treatment for the ... This study was designed to compare the effectiveness of fluconazole vs. itraconazole as mainte-nance therapy for AIDS- ... Home » A Comparison of Itraconazole Versus Fluconazole as Maintenance Therapy for AIDS-Associated Cryptococcal Meningitis ... A Comparison of Itraconazole Versus Fluconazole as Maintenance Therapy for AIDS-Associated Cryptococcal Meningitis. ...
2 weeks of AmB plus fluconazole or 1 week of AmB plus fluconazole followed by 1 week of fluconazole is an appropriate ... as well as in effective fungicidal activity (EFA) over the first 2 weeks among Regimens B, C, and D. The statistical ... 1 week of AmB plus 5-FC followed by 1 week of fluconazole, Regimen B: 1 week of AmB plus fluconazole followed by 1 week of ... Our results indicate that, 1 week of AmB plus 5-FC followed by 1 week of fluconazole is superior to the three other studied ...
Fluconazole at a dose of 400-800 mg daily is preferred (AII) (638Galgiani JN, Catanzaro A, Cloud GA, et al. Fluconazole therapy ... is endemic, they should avoid activities involving extensive exposure to disturbed native soil, such as occurs at building ... Fluconazole in the treatment of chronic pulmonary and nonmeningeal disseminated coccidioidomycosis. Am J Med 1995;98:249-56., ... Fluconazole in the treatment of chronic pulmonary and nonmeningeal disseminated coccidioidomycosis. Am J Med 1995;98:249-56. ...
It is known that the causes of RVVC are multifactorial (Sobel 2007). The knowledge about the relation of sexual activity with ... 2004, Sobel 2007). Oral fluconazole (FLZ) has also been frequently used being the first drug of choice for VVC treatment (Sobel ... Outbreak of fungemia among neonates caused by Candida haemulonii resistant to amphotericin b, itraconazole , and fluconazole. J ... The role of sexual partners, trauma of the vaginal mucosa, immunosuppressive effect of semen during sexual activity besides ...
i.e. ketoconazole, itraconazole, and fluconazole. Intravenous antifungals can be used in severe disease.. Antifungals. the ... In vitro activities of voriconazole, itraconazole, and amphotericin B against Blastomyces dermatitidis, Coccidioides immitis, ... i.e. ketoconazole, itraconazole, and fluconazole. Intravenous antifungals can be used in severe disease.. ...
In vitro activities of voriconazole, posaconazole, and fluconazole against 4,169 clinical isolates of Candida spp. and ... We examined the in vitro activities of voriconazole, posaconazole, and fluconazole against 3,932 isolates of Candida spp. and ... Both voriconazole and posaconazole were more active than fluconazole against all Candida spp. and C. neoformans. These results ...
Antifungal activity against fluconazole-resistant Candida albicans 805 after 48 hrs by spectrophotometry. ...
L-733,560 and L-743,872 are water-soluble pneumocandins with potent antifungal activity. By beginning with the NCCLS M27-T ... In vitro growth-inhibitory activity of pneumocandins L-733,560 and L-743,872 against putatively amphotericin B- and fluconazole ... L-733,560 and L-743,872 are water-soluble pneumocandins with potent antifungal activity. By beginning with the NCCLS M27-T ...
... fluconazole MIC, ≥64 μg/ml) (isolates 105, 126, and 272) and fluconazole-susceptible (FS) C. albicans(fluconazole MIC, ≤0.125 ... 1997) In vitro growth-inhibitory activity of L-733560 and L-743,872 against putatively amphotericin B- and fluconazole- ... Measurement of in vivo antifungal activity.Therapeutic response to fluconazole was measured by daily oral mucosal quantitative ... 1994) In vitro activity of itraconazole against fluconazole-susceptible and -resistant Candida albicans isolates from oral ...
Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole- ... fluconazole; ITZ, itraconazole; CAS, caspofungin; FK506, tacrolimus; FS e FR, fluconazole-susceptible and fluconazole-resistant ... fluconazole, itraconazole, and caspofungin against fluconazole-susceptible and fluconazole-resistant T. asahii strains. ... In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of ...
Antifungal activity against fluconazole-resistant Candida albicans isolate 17 after 24 to 48 hrs by NCCLS method. ...
... , Journal of Dental Research, 2011 ... triclosan antagonized the activity of fluconazole. Although triclosan induced CDR1 expression in C. albicans, antagonism was ... Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. ... Triclosan did not affect fluconazole uptake or alter total membrane sterol content, but did induce the expression of FAS1 and ...
MM-86553: a Novel Anti-Invasin antifungal Compound with Activity against Fluconazole-Resistant Candida albicans. M.E. MAYORGA, ... Fluconazole resistant clinical isolates were as sensitive to MM-86553 as fluconazole sensitive strains (31/33 [94%] FLUR vs. 83 ... To test this hypothesis we measured the activity of a potent anti-invasin compound, MM-86553, against 130 C. albicans clinical ... 94%] FLUS). Conclusions: Nearly all C. albicans clinical isolates tested, including many fluconazole resistant strains, were ...
Activity of SCH 56592 compared with those of fluconazole and itraconazole against Candida spp.. D Law, C B Moore, D W Denning ... The in vitro activity of Schering 56592, a new azole drug, was compared with those of fluconazole and itraconazole against 103 ... Activity of SCH 56592 compared with those of fluconazole and itraconazole against Candida spp. ... Activity of SCH 56592 compared with those of fluconazole and itraconazole against Candida spp. ...
Activity of fluconazole (UK 49,858) and ketoconazole against Candida albicans in vitro and in vivo.. T E Rogers, J N Galgiani ... Fluconazole (UK 49,858), a new orally administered bis-triazole, was compared with ketoconazole for activity in synthetic broth ... Activity of fluconazole (UK 49,858) and ketoconazole against Candida albicans in vitro and in vivo. ... Activity of fluconazole (UK 49,858) and ketoconazole against Candida albicans in vitro and in vivo. ...
Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole.. ... Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole.. ... OBJECTIVES: To determine the activity of newer triazoles against strains of Histoplasma capsulatum resistant to fluconazole. ... A 4-fold or greater increase in the MIC of fluconazole and voriconazole was observed in 12 and 7 of the post-treatment isolates ...
Fluconazole official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, ... Antimicrobial Activity. Fluconazole has been shown to be active against most isolates of the following microorganisms both in ... How Should I Take Fluconazole?. Take Fluconazole by mouth with or without food. You can take Fluconazole at any time of the day ... How is Fluconazole Supplied. Fluconazole Tablets. Pink trapezoidal tablets containing 50, 100, or 200 mg of Fluconazole are ...
Antimicrobial Activity. Fluconazole has been shown to be active against most isolates of the following microorganisms both in ... FLUCONAZOLE (UNII: 8VZV102JFY) (FLUCONAZOLE - UNII:8VZV102JFY). FLUCONAZOLE. 350 mg in 35 mL. ... FLUCONAZOLE (UNII: 8VZV102JFY) (FLUCONAZOLE - UNII:8VZV102JFY). FLUCONAZOLE. 1400 mg in 35 mL. ... fluconazole 10 MG per ML Powder for Oral Suspension. SY. 35. 310352. fluconazole 350 MG per 35 ML Powder for Oral Suspension. ...
Antimicrobial Activity. Fluconazole has been shown to be active against most isolates of the following microorganisms both in ... Fluconazole Tablets) (Fluconazole for Oral Suspension). DESCRIPTION. DIFLUCAN® (fluconazole), the first of a new subclass of ... FLUCONAZOLE (UNII: 8VZV102JFY) (FLUCONAZOLE - UNII:8VZV102JFY) FLUCONAZOLE. 350 mg in 35 mL. ... FLUCONAZOLE (UNII: 8VZV102JFY) (FLUCONAZOLE - UNII:8VZV102JFY) FLUCONAZOLE. 1400 mg in 35 mL. ...
CME ACTIVITY - Research. Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018 Eun Jeong Won1, ... A) Cumulative survival curves of 64 patients infected with fluconazole-resistant (FR) bloodstream infection (BSI) isolates. The ... Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018. ... Cumulative survival curves of patients infected with fluconazole-susceptible dose-dependent (F-SDD) BSI isolates (297 patients ...
CME ACTIVITY - Research. Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018 On This Page ... Medscape CME ACTIVITY In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and ... Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity ... Ko JH, Peck KR, Jung DS, Lee JY, Kim HA, Ryu SY, et al. Impact of high MIC of fluconazole on outcomes of Candida glabrata ...
Fluconazole vs amphotericin B: In vitro activity against Cryptococcus neoformans. G. Michelone, C. Cavanna, G. Lombardi, R. ... Michelone, G. ; Cavanna, C. ; Lombardi, G. ; Gulminetti, R. / ATTIVITA IN VITRO DEL FLUCONAZOLE VS AMPFOTERICINA B NEI ... Michelone, G., Cavanna, C., Lombardi, G., & Gulminetti, R. (1993). ATTIVITA IN VITRO DEL FLUCONAZOLE VS AMPFOTERICINA B NEI ... However, fluconazole proved to be more useful in the management of discharged patients, because it allowed their home treatment ...
Confers resistance to the azole derivative fluconazole (FCZ). ... fluconazole transporter activity Source: SGD ,p>Inferred from ... sp,P38124,FLR1_YEAST Fluconazole resistance protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FLR1 PE=1 SV= ... Confers resistance to the azole derivative fluconazole (FCZ).. ,p>The ,a href="http://www.geneontology.org/">Gene Ontology (GO ...
Fluconazole has fungistatic activity. It is a synthetic oral antifungal (ie, broad-spectrum bistriazole) that selectively ... Itraconazole has fungistatic activity. It is a synthetic triazole antifungal agent that slows fungal cell growth by inhibiting ... Griseofulvin has fungistatic activity. It interferes with the microtubule annd impairs fungal cell division. Griseofulvin binds ...
  • Following either single- or multiple oral doses for up to 14 days, Fluconazole penetrates into all body fluids studied (see table below). (drugs.com)
  • 21 Fluconazole is commonly given once daily, but can be prescribed twice daily for larger total daily doses. (mja.com.au)
  • Successful treatment of he- patitis C enabled the patient to tolerate increaseing doses of fluconazole. (scirp.org)
  • We aimed to assess the effect of exposure to low and high doses of fluconazole during pregnancy on the occurrence of spontaneous abortions, major congenital malformations and stillbirths. (cmaj.ca)
  • Any maternal exposure to fluconazole during pregnancy may increase risk of spontaneous abortion and doses higher than 150 mg during the first trimester may increase risk of cardiac septal closure anomalies. (cmaj.ca)
  • A single oral 150 mg dose of Fluconazole administered to 27 patients penetrated into vaginal tissue, resulting in tissue:plasma ratios ranging from 0.94 to 1.14 over the first 48 hours following dosing. (drugs.com)
  • In normal volunteers, Fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. (drugs.com)
  • People who are on dialysis should receive the full dose of fluconazole after they have finished their dialysis procedure. (everydayhealth.com)
  • Conclusions The extracts obtained from the fern species Lygodium venustum and P. calomelanos dose not present significant antifungal activity. (blogspot.com)
  • Pharmacodynamic analysis demonstrated a strong relationship between MIC, fluconazole dose, and outcome. (asm.org)
  • To treat yeast infection that has spread throughout the body (disseminated yeast infection), the recommended adult dose of fluconazole is 200 mg to 400 mg once daily, for at least 4 weeks. (medbroadcast.com)
  • Rex, J.H., Pappas, P.G. and Karchmer, A.W. (2003) A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus ampho- tericin B as therapy for candidemia and its conse-quences in nonneutropenic subjects. (scirp.org)
  • In a randomized, double-blind, double-dummy Phase 2b study, subjects received either one of five oral ibrexafungerp dose regimens (750mg-QD 1 day, 300mg-BID 1 day, 450mg-BID 1 day, 150mg-BID for 3 days, and 300-BID for 3 days) or an active comparator dose of oral fluconazole (FLU) (150mg single dose). (ptcommunity.com)
  • If your doctor has prescribed probiotics in conjunction with fluconazole, follow her dosing instructions carefully. (healthfully.com)
  • With its unique mechanisms of action, fluconazole has established a broad area of coverage in both dermatological and non-dermatological diseases. (aocd.org)
  • We have compared the dynamic transcriptional responses of three diverse yeast species to fluconazole treatment using a novel clustering algorithm. (biomedcentral.com)
  • Terbinafine 250 mg/day for 12 weeks (n = 48) was compared with fluconazole 150mg once weekly for 12 weeks (n = 45) or 24 weeks (n = 44) in patients with culture-confirmed toenail onychomycosis caused by dermatophyte infection. (springer.com)
  • In animal studies, fluconazole was very effective in prolonging survival of rats infected with a representative candidal strain. (asm.org)
  • To determine whether prophylactic fluconazole for the first 28 days of life results in a decreased incidence of candidal colonization in the VLBW infant. (aappublications.org)
  • The infants who received fluconazole ( n = 53) and placebo ( n = 50) had no statistical difference in the major risk factors known to increase the chances of candidal septicemia in the VLBW infant. (aappublications.org)
  • Prophylactic administration of fluconazole to the VLBW infant for the first 28 days of life is safe and results in a decreased risk of rectal colonization by candidal species. (aappublications.org)
  • The difference in efficacy between the honey with and without hydrogen peroxide removed was also studied, and it was found that both hydrogen peroxide and the non-peroxide components contribute to the bacteriostatic and bactericidal activity of the honey. (blogspot.com)
  • SUMMARY Developing interpretive breakpoints for any given organism-drug combination requires integration of the MIC distribution, pharmacokinetic and pharmacodynamic parameters, and the relationship between in vitro activity and outcome from both in vivo and clinical studies. (asm.org)
  • Grant, S.M. and Clissold, S.P. (1990) Fluconazole: A re- view of its pharmacodynamic and pharmacokinetic pro- perties,and therapeutic potential in superficial and sys- temic mycoses. (scirp.org)