Neutron Activation Analysis: Activation analysis in which the specimen is bombarded with neutrons. Identification is made by measuring the resulting radioisotopes. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Activation Analysis: A method of chemical analysis based on the detection of characteristic radionuclides following a nuclear bombardment. It is also known as radioactivity analysis. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Spectrometry, Gamma: Determination of the energy distribution of gamma rays emitted by nuclei. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Nails: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.Trace Elements: A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Zinc Isotopes: Stable zinc atoms that have the same atomic number as the element zinc, but differ in atomic weight. Zn-66-68, and 70 are stable zinc isotopes.Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.Hair: A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.Body Composition: The relative amounts of various components in the body, such as percentage of body fat.Zinc: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.Copper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Research Support, Non-U.S. Gov'tMicrotubule-Associated Proteins: High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.Macrophage Activation: The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Research Support, U.S. GovernmentMild Cognitive Impairment: A prodromal phase of cognitive decline that may precede the emergence of ALZHEIMER DISEASE and other dementias. It may include impairment of cognition, such as impairments in language, visuospatial awareness, ATTENTION and MEMORY.Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Memory, Episodic: Type of declarative memory, consisting of personal memory in contrast to general knowledge.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)Sex Determination Analysis: Validation of the SEX of an individual by inspection of the GONADS and/or by genetic tests.Sex Determination Processes: The mechanisms by which the SEX of an individual's GONADS are fixed.Sex Differentiation: The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain.Genes, Lethal: Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Superantigens: Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.Enterotoxins: Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.Bacterial Toxins: Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.Tampons, Surgical: Plugs or cylinders made of cotton, sponge, or other absorbent material. They are used in surgery to absorb fluids such as blood or drainage.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.British Columbia: A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.Animal Testing Alternatives: Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.Food, Genetically Modified: Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).Carcinogenicity Tests: Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Phosgene: A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Tandem Mass Spectrometry: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.

A bone calcium index based on partial-body calcium measurements by in vivo activation analysis. (1/35)

Measurements of partial-body calcium by in vivo neutron activation analysis have been carried out on normal and osteoporotic subjects. Based on measurements on 16 normal subjects (volunteers less than 55 years of age), a calcium index has been established that takes into account variation in skeletal frame size. On the basis of this index, all osteoporotic patients have bone mineral content less than any of the normal subjects. The normal calcium indices range from 0.9 to 1.2, and the osteoporotic indices ranged from 0.41 to 0.83. Thirteen of 22 volunteers over 55 years of age had calcium indices less than 0.9 in agreement with the expected loss of calcium with age. Measurements of total-body potassium were also made on these same subjects and the calcium/potassium ratios calculated. Although as groups the older volunteers and older osteoporotic subjects had mean calcium/potassium ratios similar to the mean for the normal subjects, the osteoporotic subjects under 55 years of age had a mean calcium/potassium ratio significantly lower, indicationg that for this latter group the loss in bone mineral was not associated with a corresponding loss in muscle mass.  (+info)

Phonton absorptiometry and skeletal mass in the treatment of osteoporosis. (2/35)

Thirty-six osteoporotic patients who underwent several therapeutic regimes were studied on two occasions by photon absorptiometry and total-body neutron activation analysis (TBNAA). These determinations were made at a mean interval of 8.9 plus or minus 0.8 months. The 8-cm radial site was chosen for the photon absorptiometry which was performed with the Norland-Instruments Densitometer. Mean initial bone mineral content (BMC) was 0.724 plus or minus 0.069 gm/cm and mean bone width was 1.235 plus or minus 0.072 cm. The mean percent change in BMC (%deltaBMC) was 1.02 plus or minus 4.2. The initial total-body calcium (TBCa) as determined by TBNAA was reduced when compared with values that would be expected from empirically derived formulas. The mean percent change in TB-Ca (%deltaTB-Ca) was -3.2 plus or minus 4.7. Most patients displayed a change in BMC and TB-Ca that was at least 2 s.d. greater than the precision of the methods used (%deltaTB-Ca greater than 2). No relationship was found between the deltaBMC and the deltaTB-Ca (r = 0.17). These findings suggest that changes in the radical BMC at the 8-cm site cannot be extrapolated to indicate changes in skeletal mass in response to treatment of osteoporosis. Whether photon absorptiometry at other sites or at multiple sites provides a closer relationship to changes in skeletal mass (TB-Ba) remains to be determined.  (+info)

Preliminary observations on excretion of 37Ar from man following whole-body neutron activation--an indicator of total-body calcium. (3/35)

Measurements of exhaled 37-Ar produced by total-body neutron irradiation of 40-Ca were used to determine total-body calcium in 16 human subjects. There was a good correlation between body calcium using the 30-min postirradiation breath sample of 37-Ar and body calcium determined by measurement of 49-Ca.  (+info)

Effects of activation sequence on the local recovery of ventricular excitability in the dog. (4/35)

We measured refractory periods at ventricular sites in the dog heart during drive from ventricular test sites and during combined drive from the test sites and other ventricular sites or the atrium. We found that ventricular activation sequence caused significant alterations on refractory period. Combined drive from two sites which resulted in fusion complexes was associated with shorter refractory periods at the test sites than those observed during drive at the test sites only. Our findings are explicable because earlier excitation and consequent earlier recovery of surrounding areas during fusion beats exerts an electrotonic influence on test sites.  (+info)

Length-induced changes in activation during contraction. A study of mechanical oscillations in strontium-mediated contractions of cat and frog heart muscle. (5/35)

The plateau phase of prolonged Sr-mediated contractions of preparations of cat and frog heart muscle was used to study the transient response to abrupt changes in load or length. An oscillatory response (total amplitude equal to or less than 5% Lmax) was obtained. Isotonic oscillations were less damped than their isometric counterparts, implying positive feedback and thus a causal role of the perturbation in length. Oscillation frequency was 2-3 HZ at 29 degrees C (Q 10, 2-3); it could be increased by epinephrine or caffeine, independently of their effects on extent of shortening; it otherwise changed as a generally constant function of the length at which the oscillation occurred, whether this was altered by changes in extracellular [Sr], frequency of contraction, or load (independent of the direction and magnitude of the preceding load step). Similar oscillatory responses were induced during Sr- or Ca-mediated contractures. Cat muscles showed an additional slower component to the oscillatory response. Transient augmentation of the velocity-length relationship after abrupt reduction in load, previously described for twitch contractions under certain conditions, appears to be analogous to the first phase of the oscillatory response studied here. Our findings indicate that the oscillation is not attributable to any mechanism intrinsic to myofilament interaction, but rather that it involves length-induced changes in the level of activation, probably mediated by Ca2+ or Sr2+. We conclude that length influences the level of activation during contraction of heart muscle.  (+info)

MICROSCOPIC DETERMINATION OF BONE PHOSPHORUS BY QUANTITATIVE AUTORADIOGRAPHY OF NEUTRON-ACTIVATED SECTIONS. (6/35)

Longitudinal sections of human cortical bone were submitted to thermal neutrons. gamma-ray spectra were recorded repeatedly during 15 days following irradiation. They showed that Na(24) is predominant as early as 3 hours after activation and that all the gamma-emitters have decayed on the 15th day. When the gamma-rays have disappeared, beta-rays are still produced by the sections. It was proved by the absorption curve in aluminium that all these beta-rays are issued from the P(32) induced in the sections by activation of P(31). Therefore autoradiograms registered 15 days after activation reveal the distribution of P(32) in the sections. gamma-ray spectra and beta-ray absorption curves of neutron activated sections of ivory demonstrated a mineral composition similar to that of bone. Autoradiograms of ivory sections activated for various times were used to establish the relation between the optical density of the autoradiograms and the radioactivity in P(32). When the bone autoradiograms are compared with the ivory standards of known radioactivity, the optical densities of single osteons (Haversian systems), can be related to their phosphorus contents. Autoradiograms and microradiograms of the same sections were examined side by side. The least calcified osteons, that contain 80 per cent of the calcium of the fully calcified osteons, also contain about 80 per cent of the phosphorus of the fully mineralized osteons. It is concluded that the Ca:P ratio remains constant while mineralization of bone tissue is being completed.  (+info)

Heparin-stimulated inhibition of factor IXa generation and factor IXa neutralization in plasma. (7/35)

Generation and inhibition of activated factor IXa was studied in factor XIa-activated plasma containing 4 mmol/L free calcium ions and 20 mumol/L phospholipid (25 mol% phosphatidylserine/75 mol% phosphatidylcholine). Interference of other (activated) clotting factors with the factor IXa activity measurements could be avoided by using a highly specific and sensitive bioassay. Factor IXa generation curves were analyzed according to a model that assumed Michaelis-Menten kinetics of factor XIa-catalyzed factor IXa formation and pseudo first order kinetics of inhibition of factor XIa and factor IXa. In the absence of heparin, factor IXa activity in plasma reached final levels that were found to increase with increasing amounts of factor XIa used to activate the plasma. When the model was fitted to this set of factor IXa generation curves, the analysis yielded a rate constant of inhibition of factor XIa of 0.7 +/- 0.1 min-1 and a kcat/Km ratio of 0.29 +/- 0.01 (nmol/L)-1 min-1. No neutralization of factor IXa activity was observed (the estimated rate constant of inhibition of factor IXa was 0). Thus, in the absence of heparin, the final level of factor IXa in plasma is only dependent on the initial factor XIa concentration. While neutralization of in situ generated factor IXa in normal plasma was negligible, unfractionated heparin dramatically enhanced the rate of inactivation of factor IXa (apparent second order rate constant of inhibition of 5.2 min-1/per microgram heparin/mL). The synthetic pentasaccharide heparin, the smallest heparin chain capable of binding antithrombin III, stimulated the inhibition of in situ generated factor IXa, but sevenfold less than unfractionated heparin (k = 0.76 min-1 per microgram pentasaccharide/mL). We found that free calcium ions were absolutely required to observe an unfractionated heparin and pentasaccharide-stimulated neutralization of factor IXa activity. Factor XIa inhibition (psuedo first order rate constant of 0.7 min-1) was not affected by unfractionated heparin or pentasaccharide in the range of heparin concentrations studied.  (+info)

Post-separation detection of nucleic acids and proteins by neutron activation. (8/35)

We describe approaches to neutron activation analysis and their application to post-separation autoradiographic detection of biological compounds. Specifically, we have extended the use of a "direct-labeling" method to the post-separation detection of DNA after gel electrophoresis and to the detection of nucleotides separated by TLC. In addition, we describe a more generally applicable "indirect-labeling" method in which separated compounds of interest are selectively bound to ligands containing highly neutron-activatable elements, such as manganese (55Mn), europium (151Eu), or dysprosium (164Dy), and then irradiated with thermal neutrons. This method is illustrated with nucleotides separated by TLC and with proteins separated by polyacrylamide gel electrophoresis. In contrast to the direct-labeling approach, the indirect-labeling method can be adapted to detect any class of substances for which a highly neutron-activatable, selectively binding ligand is available. The theoretically achievable sensitivity of the indirect-labeling method is in the attomole (10(-18) mol) range.  (+info)

Calcium is an essential daily nutrient. Critical functions of life are dependent on narrow concentration limits for plasma calcium, which is subject to obligatory losses from the body requiring a complex homeostatic mechanism and a daily nutrient intake. Stringent regulation of plasma calcium homeostasis is maintained by an intricate pathway of agents for which the biologically active metabolite of vitamin D, 1,25-diydroxyvitamin D, is one component. Ninety nine per cent of total body calcium is present in the skeleton. One of its functions is as a store of body calcium. Vitamin D exerts activities as an endocrine agent at the intestine, kidney and bone tissues and as an autocrine/paracrine agent within bone tissue to both stimulate bone mineral resorption and inhibit bone formation or to inhibit bone resorption and stimulate bone formation. These activities are coordinated by a range of regulatory factors to maintain plasma calcium homeostasis with secondary effects on bone-mineral ...
Calcium is the most abundant mineral in the human body and has several important functions. More than 99% of total body calcium is stored in the bones and teeth where it supports the structure. The remaining 1% is found throughout the body in blood,
Neutron activation analysis (NAA) is a precise analytical method, which serves to establish the elemental composition of investigated samples, both quantitative and qualitative. The method is based on the transformation of originally stable atoms in the analysed substance into unstable isotopes, after interaction with neutrons produced in the reactor. The break-up of these unstable nuclides is usually accompanied by characteristic gamma radiation, which is possible to measure, and from its amount subsequently to ascertain a representation of the original mother element. The sensitivity of the method is different for different elements, depending on their atomic characteristics and neutron field parameters, in which the irradiation took place. To examine changes in the neutron field it is possible using NAA methods to use one of three types of standardisation: absolute, relative or comparative.. The LVR-15 reactor is equipped with one channel with pneumatic equipment which allows rapid transport ...
Research on the application of soluble, metal chelates for water tracing using thermal neutron activation analysis for tracer determination has led to the development of several tracers with promising solution stabilities (conservative behavior) and determination sensitivities. The solution stabilities of the ethylenediamine tetraacetic acid (EDTA) and the diethylenetriamine pentaacetic acid (DTPA) chelates of the activable elements Cr, Co, Eu, In, Sb, Sc and Tb were evaluated in a series of laboratory, radiotracer experiments conducted under simulated field conditions. They showed that 1) chelation of metals produces highly conservative solution behavior, 2) DTPA is generally better than EDTA for improving tracer behavior, 3) non-chelated metals are rapidly sorbed onto sediments and 4) chelation reduces sorption of metals onto sediments. Field tests of EuDTPA, TbDTPA, InDTPA and Rhodamine B fluorescent dye in a small eastern Washington stream demonstrated that the metal chelates have ...
Accurate estimates for the molecular transport coefficients are critical to predicting the movement of gases in geological media. Here I present a novel methodology for using prompt gamma activation analysis to measure the effective diffusivity of noble gases in a porous medium. I also present a model to estimate the connectivity parameter of a soil from measurements of its saturated conductivity, macro porosity, and pore volume and pore surface fractal dimensions. Experiments with argon or xenon diffusing through a nitrogen saturated geological media were conducted. The noble gas concentration variations at its source were measured using prompt gamma activation analysis and later compared to a numerical diffusion model to estimate the effective diffusion coefficient. Numerical simulations using the estimated diffusivity and the experimental argon data produced results with a correlation parameter R² = 0.98. However, neglecting transport mechanisms other than diffusion largely under-predicted ...
An instrumental neutron activation method for V, Mn and W in alloy steels with a 241 Am/Be isotopic neutron source is described. The samples were irradiated to induce the nuclear reactions 51V(n, γ) 52V, 55Mn(n, γ)56Mn, and 186W(n, γ)187W. The activities were measured with a NaI(TI) detector. Interferences on the measured photopeaks were shown to be negligible by measuring the half-lives of 62V, 56Mn and 187W.These thre elementes were determined in the range 1.512.9% in special steels; manganese in the range 0.51.6% was measured in cast irons. Calibration was done by comparison with results from wet chemistry and x-ray fluorescence spectrometry. The processing times for the vanadium, manganese and tungsten determinations were 11 min, 3 h and 26.3 h, respectively, but these were reduced greatly by intoruding a scheme wherein six samples were simultaneously irradiated and the 56Mn and 187W nuclides were measured sequentially for a series of 66 samples. The average processing time was reduced to ...
Twenty-three (23) industrial, commercial and government laboratories participated in an interlaboratory measurement program using methods of their own choosing. The methods for zinc involved multi-acid digestions followed by iron separation, use of complexing agents and analysis of the filtrate by atomic absorption spectroscopy and fusion of the insoluble, ion exchange and solvent extraction. The determinations involved titrations with ethylenediaminetetraacetate and ferrocyanide, atomic absorption, and instrumental neutron activation analysis. Both fused pellet or fusion followed by X-ray fluorescence, as well as ISO 12739:2006 and ISO/TC 183 N 360 were used by some laboratories.. Other elements were determined by multi acid digestions, microwave digestion, fusion, fire assay (for gold and silver), flame atomic absorption spectroscopy, gravimetric analysis, inductively coupled plasma - optical emission spectroscopy, and instrumental neutron activation analysis. Some laboratories added bromine ...
TY - JOUR. T1 - Comparative PGAA and NAA results of geological samples and standards. AU - Gméling, K.. AU - Simonits, A.. AU - Sziklai László, I.. AU - Párkányi, D.. PY - 2014. Y1 - 2014. N2 - Concentrations of major and trace elements in volcanic rock and soil samples, including geological standard reference materials, were determined by neutron activation analysis (NAA) and prompt gamma activation analysis (PGAA), both using the k0-standardization method. The paper highlights the different experimental procedures, such as sample preparation, data collection and spectrum evaluation. In geological samples, PGAA gives precise results for major elements (Si, Ti, Al, Fe, Mn, Mg, Ca, Na, K and-as a unique method-for H), for some of the light trace elements as B and Cl, as well as for Sc, S, Cr, Co, Ni, Cd, Nd, Sm and Gd. NAA is sensitive for the rare earth elements, and for many major (Ti, Al, Fe, Mn, Mg, Ca, Na, K) and trace elements (e.g.: Sc, V, Cr, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Zr, As, ...
This study compiles and evaluates data from many sources to expand a base of data from which to estimate the activity concentrations and volumes of greater-than-Class C low-level waste that the Department of Energy will receive from the commercial power industry. Sources of these data include measurements of irradiated hardware made by or for the utilities that was classified for disposal in commercial burial sites, measurements of neutron flux in the appropriate regions of the reactor pressure vessel, analyses of elemental constituents of the particular structural material used for the components, and the activation analysis calculations done for hardware. Evaluations include results and assumptions in the activation analyses. Sections of this report and the appendices present interpretation of data and the classification definitions and requirements.
BNA technology is based on a network model to depict functional connectivity. The descriptive network model approach provides insights regarding inter-connectivity of brain networks and can describe the temporal-spatial brain activation patterns applied to various types of data-sets including EEG, MEG and fMRI.. In this study it is proposed that synchronization in brain activity may be disrupted in patients who experience frequent seizures and may correspond to functional impairments (e.g., memory, processing speed). As such, BNA analysis may provide additional data that complement current functional assessments, inform clinical assessment and management of epilepsy, and identify subgroups of patients that might be at risk for poor treatment outcomes. ...
Coal is difficult to digest but neutron activation analysis (NAA) uses a direct measurement to avoid problems that are common when looking for trace elements in coal.
1. Iron absorption from 10 mg Fe (as ferrous sulphate), labelled with 1.3 mg 58Fe, was measured in fasting, non-anaemic adult subjects by the faecal-balance technique. The measurement was performed twice, each subject being given, in random order, either 50 mg Fe or a placebo 18 h before the 58Fe-labelled FeSO4. 2. The 50 mg Fe load significantly reduced Fe absorption the following day (P less than 0.01), from a mean of 35.4 (SEM 4.6)% to 29.0 (SEM 5.1)%. This points to the importance of strict dietary control during Fe-absorption studies to eliminate bias in results. 3. In a separate study, the feasibility of using 58Fe-enrichment of erythrocytes, measured by neutron activation analysis (NAA), 10 d after a meal labelled with 0.69 mg 58Fe as an index of Fe absorption was examined. The levels of 58Fe in the blood were detectable by NAA. Regression analysis showed a significant relation between 58Fe-enrichment of blood and 58Fe absorption, calculated as the difference between intake and faecal ...
Objectives-To study longitudinal biological monitoring data on urinary and blood cadmium collected in a small cohort of nine workers who had been brazing for several years with solders containing cadmium. Methods-Cadmium was measured by neutron activation analysis in livers and kidneys, and estimates of renal function were carried out in 1983...
Radiation chemistry,br,Topics:,br,- Irradiation methods,br,o Types of irradiation sources and devices,br,o Dosimetrics,br,o Effects of irradiation geometry, thickness of the target etc.,br,o Use of data basis and related computer programmes,br,- Reactions in radiation chemistry in various materials,br,o Basic reactions, formation of intermediates, excited states, ions, electrons and,br,radicals,br,o Reaction of intermediates, formation of stable products,br,o Radiation chemical yields,br,o Kinetics of radiolysis,br,o Reactions in water and water solutions, polymers, metals, nuclear fuel, nutrients,,br,cells etc.,br,- Analytical methods used in radiation chemistry,br,- Application of radiation chemistry,br,o radiation sterilization of medical equipment,br,o radiation sterilization of food stuffs,br,o polymerization and polymer functionalization,br,o etc.,br,12. Nuclear and radioanalytical methods,br,Topics:,br,- Radioimmunoassay (RIA),br,- Neutron activation analysis (NAA) - instrumental and ...
A far cry from the traditional archaeological methods, Dr Popelka-Filcoff, the President-Elect of the International Society for Archaeological Sciences, uses radio-analytical and spectroscopic methods such as neutron activation analysis (NAA) and X-ray fluorescence microscopy (XFM) to unravel the stories of the ochre trade.. Ochre is an iron oxide pigment naturally occurring in a range of red, brown, orange and yellow colours across Australia, and has featured in Aboriginal art for thousands of years.. Dr Popelka-Filcoff is examining the types of ochre used on boomerangs, shields and bark paintings, and matching it to the elemental composition of known ochre sources across the country. By examining the artefacts and researching the chemical and physical characteristics of the pigments, she can piece together key points in the ancient ochre exchange routes.. "Ochre is a very culturally important material and because of that, people would travel to various sites to mine the material and would ...
1984) Cystic fibrosis in England and Wales and in Victoria, Australia 1976-1980. Arch. Dis. , 59, 71-83. 85. , Koch C. and H0iby, N. (1996) Improved survival in the Danish Center-treated cystic fibrosis patients: results of aggressive treatment. Pediatr. 273. 99. , Gurkan, M. and Pala, S. (1973) Newborn screening for cystic fibrosis with chloride electrode and neutron activation analysis. Helv. Paediatr. Acta, 28, 165-174. 100. O. ,68,113-119. , 21, 153-158. 86. A. (1998) Inferences for health provision from 101. CDNA copies of these transcripts could then be used as radioactively labeled probes to look for hybridization with DNA fragments from flow-sorted chromosome 7 libraries21. 11, and to look for sequences that were candidates for the CF gene. The task of moving from the genetic map of the region to the precise molecular definition of the disease was a very formidable one because of the physical distance involved. 11 was thought to represent 5000 kb of DNA sequence. A region of this size ...
AA Stands For Alliteration and Assonance, Associate in Arts, Associate of Arts, Acetic Acid, Activation Analysis, Advanced Alloy, Amino Acid, Amino Acrylate, Arachidonic Acid, Ascorbic Acid, Atomic Absorption, Academic Affairs, Advanced Auditing, Alpha Alumni, Alumni Affairs, Ancient Arts, Active Active, Anti Aliasing, Atomic Absorption, Audio Animatronics, Automatic Adjust, Authors Addition, Authors Alteration, Adaptive Algorithm, Almost All, Angle Angle, Argument Analysis, Academic Alliance, Assistant Administrator, Achievement Age. ...
To determine the percent of patients with refractory breast cancer where molecular profiling and RPMA-based protein pathway activation analysis of their tumor, can change the clinical course of their disease (i.e. produce a Growth Modulation Index (GMI) ≥1.3). The GMI is calculated as the ratio of Progression-free survival (PFS) under molecular profiling and RPMA analysis selected treatment to the time to progression (TTP) for the most recent regimen the patient has progressed on ...
Survival analysis 生存分析 ; 生存分析法 ; 存活分析 ; 存活率分析 Job analysis [管理] 工作分析 ; [计] 作业分析 ; 职业分析 ; 职位分析 Factor Analysis [经] 因素分析 ; 因素分析法 ; 因子分析法 ; 因子生态分析 thermal analysis [冶] [分化] 热分析 ; 热分析法 ; 热学分析 ; 热力分析 Static analysis [计] 静态分析 ; 静强度分析 ; 静力学分析 ; 静力计算 modal analysis [力] 模态分析 ; 模式分析 ; 模态 ; 众数分析 activation analysis [分化] 活化分析 ; [核] 激活分析 Fault Analysis [科技] 故障分析 ; 失效分析 ; 事故分析 Reliability Analysis [计] 可靠性分析 ; 信度分析 ; 可靠度分析 ...
Mutations in sorting nexin 10 (Snx10) have recently been found to account for roughly 4% of all human malignant osteopetrosis, some of them fatal. To study the disease pathogenesis, we investigated the expression of Snx10 and created mouse models in which Snx10 was knocked down globally or knocked out in osteoclasts. Endocytosis is severely defective in Snx10-deficient osteoclasts, as is extracellular acidification, ruffled border formation, and bone resorption. We also discovered that Snx10 is highly expressed in stomach epithelium, with mutations leading to high stomach pH and low calcium solubilization. Global Snx10-deficiency in mice results in a combined phenotype: osteopetrosis (due to osteoclast defect) and rickets (due to high stomach pH and low calcium availability, resulting in impaired bone mineralization). Osteopetrorickets, the paradoxical association of insufficient mineralization in the context of a positive total body calcium balance, is thought to occur due to the inability of the
Calcium is an essential mineral needed every day for proper health.* 99% of the bodys calcium can be found in the bones and teeth. This mineral pr.... View full details ...
This is THE thread where you can post ANY question about macros like looking for a rogue macro..., what does this macro do..., or a macro that does this..., etc... Be descriptive of what you want. Use QUOTES when you reply to someone!
new op-tions: in-herit height, ver-ba-tim ig-nore per-cent - li-brary skins * new style en-hanced stan-dard jig-saw - li-brary mag-a-zine: * new macro: \if-boxar-rayempty - li-brary break-able: * op-tion break at al-lows neg-a-tive val-ues now. * the al-go-rithm for breaks in-side a mul-ti-col-umn en-vi-ron-ment was im-proved (user code may be af-fected by this change). * new macro: \tcb-break - li-brary minted: * the de-fault set-tings for minted op-tions are sup-ple-mented by break-lines,au-to-gob-ble - new li-brary poster * new macros and en-vi-ron-ments: tcb-poster, \tcb-poster-set, \poster-box, poster-box-env, tcb-poster-width, tcb-poster-height, tcb-poster-colspac-ing, tcb-poster-rows-pac-ing, tcb-poster-columns, tcb-poster-rows, tcb-poster-col-width, tcb-poster-rowheight * new op-tions: poster, columns, rows, colspac-ing, rows-pac-ing, spac-ing, showframe, width, height, pre-fix, cov-er-age, no cov-er-age, boxes, ...
It was found that trace amount of various ions could be effectively adsorbed onto hydrous magnesium oxide from aqueous solution. Attempts were made to investigate the feasibility of using hydrous...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Continuous M-Reps. In earlier work [4], we developed a deformable modeling framework called the continuous medial representation (cm-rep), which, in simplest terms, is a continuous analog of the m-rep approach by Pizer et al . [3]. Cm-reps are deformable templates that have a special property that the skeleton (medial axis) of the template preserves its branching topology (number and configuration of its branches) during deformation. Furthermore, the skeleton of the deforming template is modeled explicitly as a continuous manifold and the exact geometric relationship between the skeleton and the templates boundary is captured. The skeleton-boundary relationship makes it possible to define a special shape-based coordinate system on the interior of the template. One of the coordinate axes connects points on the skeleton to the corresponding (nearest) points on the boundary, while the other two axes parameterize the skeleton as well as the boundary. As argued in [5], this coordinate system is a natural
Hyperkalemia in diabetes is not uncommon, and has been thought to reflect renal retention of potassium. The goal of this study was to test this hypothesis by measuring total body potassium in hyperkalemic diabetic patients and normokalemic diabetic controls. We measured total body potassium (whole body counting of 40K), total body sodium, calcium, and chloride by neutron activation analysis, total body carbon by inelastic neutron scattering, and total body water from the distribution of 3H20.
anganese (Mn) is an essential mineral but is toxic when taken in excess. However, whether its interactions with other minerals in organs and cells are involved in mechanisms underlying Mn toxicity is poorly understood. It was designed a developmental rat model of chronic Mn treatment (Group A: 1 mg MnCl2.4H2) per ml of drinking water; Group B: 10 mg MnCl2.4H2) per ml of drinking water; Group C: 20 mg MnCl2.4H20 per ml of drinking water; Control Group given water without Mn Addition). Employing the model and instrumental neutron activation analysis, two hypotheses were investigated: (i) chronic manganese treatment alters the brain regional distribution of manganese and this altered manganese distribution also leads to region-specific changes of other metals; (ii) chronic manganese treatment induces differential changes in subcellular distributions of metals and electrolytes. In the treated rats, brain Mn level showed dose-related increases, the most pronounced being noted in striatum, ...
Biochemical indicators of renal dysfunction have been compared with liver and kidney cadmium levels measured by neutron activation analysis in a group of 37 cadmium smelters. Higher than normal concentrations of cadmium in the liver reflect past expo
Twenty-one industrial, commercial and government laboratories participated in an interlaboratory measurement program using methods of their own choice.. Methods for the determination of the elements included digestion with various combinations of acids on a hot plate; and various types of fusions followed by the determination using inductively coupled plasma - atomic emission spectroscopy and inductively coupled plasma - mass spectrometry. Instrumental neutron activation analysis and X-ray fluorescence on a pressed powder pellet, fused pellet or after a fusion were used for many elements.. The concentration of carbon was determined using combustion followed by infrared spectrometry.. The concentration of sulphur was determined using combustion followed by infrared spectrometry; acid digestion using four acids or fusions followed by inductively coupled plasma - atomic emission spectroscopy, inductively coupled plasma - mass spectrometry or X-ray fluorescence.. ANOVA was used to calculate the ...
The problem of global contamination from uranium (U) is a difficult task. The present investigation was aimed to study the possibilities of using prostate tissue as a biological material for global environmental monitoring of U. The U content in non-hypertrophic prostate of apparently healthy 64 residents of uncontaminated territory was measured by instrumental neutron activation analysis and inductively coupled plasma mass spectrometry. Mean values (M  SΕΜ) for the mass fraction of U in prostate of all subjects taken together was 0.0049 ± 0.0014 mg/kg of dry tissue. In order to estimate the effect of age on the investigated parameter we used three age groups: 13-20 years, 21-40 years, and 41-60 year. Mean values (M  SΕΜ) for the mass fraction of U (mg/kg of dry tissue) in age groups were as follows: 0.0023 ± 0.0007, 0.0021 ± 0.0005, and 0.0077 ± 0.0026, respectively. For the first time statistically significant (p ï‚£ 0.05, t- test) and exponential increase of the U content in
Obsidian ; Prehistoric Central Europe ; Prehistoric Eastern Europe ; Trace element characterization ; Neutron activation analysis ; Zemplen Mountains, North Eastern Hungary ; Mousterian period ; Neolithic and Copper and Bronze Ages
The concentrations of I-129 and the ratios of I-129/I-127 in normal human thyroids collected in Tianjin, China, and some seaweed samples from the Chinese coast were determined by neutron activation analysis. The mean I-129/I-127 ratio in these thyroids was found to be 1.13 x 10(-9), which is two orders of magnitude higher than the level of the pre-nuclear era, but one order of magnitude lower than the level in Europe in the post-nuclear era. There is no significant difference between the ratio of I-129/I-127 in the thyroids for the post-nuclear era from China and other areas, which are considered not to have been directly exposed to 129I emission from a nuclear source, such as Chile, Taiwan and Tokyo. The mean I-129/I-127 ratio in seaweed from the Chinese coast is 2.35 x 10(-10), approximately two orders of magnitude higher than in seaweed collected in the pre-nuclear age, and similar to that from locations without direct exposure to the emission from nuclear installations, influenced only by ...
UWFDM-882 Pulsed/Intermittent Activation in Fusion Energy Reactor Systems; J.E. Sisolak, S.E. Spangler, D.L. Henderson, March 1992 [Prepared for the 10th Topical Meeting on the Technology of Fusion Energy, 7-12 June 1992, Boston MA (Fus. Tech. 21 (May 1992) 2145]. (10 pages, 592 kB) UWFDM-997 Qualitative Analysis of Physical and Mathematical Approximations Necessary for Induced Radioactivity Calculations in Fusion Devices; P.P.H. Wilson and D.L. Henderson, November 1995 [To be published in Fusion Engineering and Design]. (20 pages, 1.5 MB) UWFDM-980 RACC-Pulse: A Version of the RACC Radioactivity Code for Pulsed/Intermittent Activation Analysis; Q. Wang and D.L. Henderson, May 1995. (25 pages, 756 kB) UWFDM-628 Radioactivity in the Light Ion Fusion Target Development Facility; D.L. Henderson, R.R. Peterson, and G.A. Moses, February 1985 [Presented at the Sixth Topical Meeting on the Technology of Fusion Energy, San Francisco, CA, 3-7 March 1985; Fusion Tech. 8, (July 1985) 1396]. (9 pages, 809 ...
In July, 2012, four researchers at Ryerson University in Toronto, Canada, published a study in "Bone" entitled: "Monitoring bone strontium levels of an osteoporotic subject due to self-administration of strontium citrate with a novel diagnostic tool, in vivo XRF: a case study." This study is significant because it used a non-invasive method (not an invasive method, such as bone biopsy) to analyze the strontium levels of bones in an osteoporotic patient who began taking strontium citrate for the study. Therefore, it was possible to obtain her baseline bone strontium levels prior to initiation of therapy with strontium citrate. The researchers wrote: "By 120 hours, the increase (in bone strontium level) was statistically significant at 0.68 ± 0.07 and 0.93 ± 0.05 (for the finger and ankle), respectively. Further increases occurred within an interval of 90-180 days, with the most recent, after 800 days, at the finger and ankle being 7 and 15 times higher than the initial baseline reading. The ...
In July, 2012, four researchers at Ryerson University in Toronto, Canada, published a study in "Bone" entitled: "Monitoring bone strontium levels of an osteoporotic subject due to self-administration of strontium citrate with a novel diagnostic tool, in vivo XRF: a case study." This study is significant because it used a non-invasive method (not an invasive method, such as bone biopsy) to analyze the strontium levels of bones in an osteoporotic patient who began taking strontium citrate for the study. Therefore, it was possible to obtain her baseline bone strontium levels prior to initiation of therapy with strontium citrate. The researchers wrote: "By 120 hours, the increase (in bone strontium level) was statistically significant at 0.68 ± 0.07 and 0.93 ± 0.05 (for the finger and ankle), respectively. Further increases occurred within an interval of 90-180 days, with the most recent, after 800 days, at the finger and ankle being 7 and 15 times higher than the initial baseline reading. The ...
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Phosphorus even works in our bodies to efficiently use carbohydrates and fat. Phosphorus is a dietary Gal Friday...wearing a dozen hats and ensuring that essential functions go off without a hitch.. Phosphorus is the second most abundant mineral in our bodies (calcium is the first). Luckily, phosphorus is found naturally in many food sources. Its prevalence is highest in animal products (fish, chicken and beef), but it can also be found in milk products, peanuts, tofu and soybeans. The recommended daily phosphorus intake for a healthy adult is about 700mg/day, and if youre meeting your daily protein requirements, chances are youre stocked up on phosphorus too.. Perhaps counterintuitively, the concern we need to have with phosphorus is that we may on occasion get too much. While the RDA is 700mg, the upper limit of daily phosphorus is 4,000mg/day. Thats a huge disparity, and it would be tough to eat that much protein in a single day to account for 4,000mg of phosphorus. The way you quadruple ...
Worried about your caffeine intake interfering with your bodys calcium absorption? Caffeine can slightly reduce calcium absorption, but this is significant only if you arent consuming adequate calcium.
Is your body calcium deficient & are you searching for measures to prevent it? Your search ends here as weve got exhaustive tips to prevent calcium deficiency!
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is defined, this macro expands to nothing. By default, the macro expands to const. The macro can be used in place of const for functions that return a value that should not be modified. The purpose of this macro is to allow us to turn on const for returned constant strings by default, while allowing programmers who find that annoying to turn it off. This macro should only be used for return values and for "out" parameters, it doesnt make sense for "in" parameters.. ...
Excel & tiedonsyöttö Projects for $10 - $30. I have two files: 1) Export File 2) Formatted Export File I need a Macro that will take the exported file, and automatically format it to look like I need it to. I will provide a list of the formatti...
I have an excel file with two sheets: Contents of the first sheet: Column 1 Column 2 Column 3 Column 4 a 45 33 5423 d 66 66 4 f 2 2 1 g 2 2 3 s 33 3 2 Contents of the second sheet: Column 1 Column...
The weanling Wistar rats of iodine deficiency were divided into three groups for supplementation of different levels of iodine (iodine-excessive [IE], iodine-adequate [IA], and iodine-deficient [ID]), with a control group (C). The iodine content in the thyroid was determined by epithermal neutron activation analysis. The activities of 5-deiodinase and 5-deiodinase in the brains were assayed by determining the conversion ratios of T4 to T3 and rT3, respectively. The thyroid hormones levels in serum were also tested. The results indicated that the ID group had a goiter containing a small amount of iodine, but the IE group had a slightly swollen thyroid with rich iodine; the concentration of iodine per unit mass of thyroid was lower in group IE than in groups IA and C. The highest 5-deiodinase and lowest 5-deiodinase activities in group ID and the lowest 5-deiodinase activity in group IE were found. The iodine deficiency or excess resulted in a compensated hypothyroid state. The results suggest ...
This publication documents the work performed within an IAEA coordinated research project (CRP) on developing techniques for small scale indigenous 99Mo production using low enriched uranium (LEU) fission or neutron activation. This captures the steps participants undertook in examining the feasibility of becoming small scale 99Mo producers. Most participants carried out work related to the entire production process, from target assembly through irradiation, planning for target disassembly in hot cells, chemical processing of targets, quality control practices, and managing waste streams. Some participants focused on one particular area, for example, testing new methods for production of LEU foil for targets and the production of gel generators from 99Mo solution. The publication aggregates all of the work undertaken as part of the CRP in order to present the results as a whole.. ...
The calcium-sensing receptor is a multimodal, multimetabolic sensor that mediates the feedback-dependent control of whole body calcium metabolism. Remarkably, in addition to its role in Ca(2+)(o) (extracellular Ca(2+)) sensing, the CaR (Ca(2+)-sensing receptor) also responds to L-amino acids. L-amino acids appear to activate, predominantly, a signalling pathway coupled with intracellular Ca(2+) mobilization, require a threshold concentration of Ca(2+)(o) for efficacy and sensitize the receptor to activation by Ca(2+)(o). Here, we review the evidence that the CaR, like other closely related members of the class 3 GPCR (G-protein-coupled receptor) family including GPRC6A, is a broad-spectrum amino acid-sensing receptor, consider the nature of the signalling response to amino acids and discuss its physiological significance.
Bone Calcium is a unique nutritional supplement formulated with calcium-rich, high collagen Microcrystalline Hydroxypatite (MCH).
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Strengthen your whole body with this AMRAP-style total-body kettlebell workout from kettlebell-certified trainer Ava Fagin of Body Space Fitness in NYC.
... and neutron activation analysis. Inductively coupled plasma-atomic emission spectroscopy (ICP-AES) is used for zinc ... of zinc in urine samples requires extraction of the metals with a polydithiocarbamate resin prior to digestion and analysis ( ...
Activation kinetics are unaffected by RNA editing.[11] Changes in inactivation kinetics affect the duration and frequency of ... This was determined by electrophysiology analysis.[14] The length of time the membrane is depolarised is decreased, which also ... "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A ... "Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia". Neurogenetics. 8 (2): 131-5. doi ...
platelet activation. • Fc-epsilon receptor signaling pathway. • cellular response to mechanical stimulus. • phagocytosis, ... 1i4l: CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP IN COMPLEX WITH ARFAPTIN (P41) ... Di-Poï N, Fauré J, Grizot S, Molnár G, Pick E, Dagher MC (Aug 2001). "Mechanism of NADPH oxidase activation by the Rac/Rho-GDI ... Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH (Apr 2012). "RAC1 activation mediates Twist1- ...
Keller, F. (1968). "Goodbye teacher..." Journal of Applied Behavior Analysis, 1, 79-89. Behavioral activation. ... Keller's paper "Goodbye teacher..." issued in Journal of Applied Behavior Analysis in 1968 introduced Personalized System of ...
1990). "Serum amyloid A, an acute phase protein, inhibits platelet activation". J. Lab. Clin. Med. 116 (2): 180-6. PMID 1697614 ... Five different variants from one individual demonstrated by cDNA sequence analysis". Biochem. J. 268 (1): 187-93. doi:10.1042/ ... mapping to chromosome 11p15.1 by physical and genetic linkage analysis". Genomics. 19 (2): 221-7. doi:10.1006/geno.1994.1051. ...
nitrogen catabolite activation of transcription from RNA polymerase II promoter. • negative regulation of tumor necrosis factor ... 1osh: A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR ... One of the primary functions of FXR activation is the suppression of cholesterol 7 alpha-hydroxylase (CYP7A1), the rate- ... 1osv: STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR ...
"Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223)". Journal of Immunology. 173 ... "Entrez Gene: LAG3 lymphocyte-activation gene 3".. *^ a b c Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas ... with this LAG3 contributing to APC activation.[42] In August 2002 the first phenotypic analysis of the murine LAG-3 was ... molecular analysis of the negative regulatory function of lymphocyte activation gene-3". Journal of Immunology. 169 (10): 5392- ...
Pulsed Fast Thermal Neutron Activation) and the prompt gamma neutron activation analysis (PGNAA). It relies on activation of ... "Prompt gamma neutron activation analysis (PGNAA)." The Cement Plant Operations Handbook. Fifth ed. October 2007. Bond, J.E.; ... The technology most frequently found in bulk material analysis and coal analysis is PFTNA ( ... Capitalizing on the unique gamma ray spectrum associated with each element, the instrument can perform an analysis each minute ...
Katsafanas, GC; Schirmer, EC; Wyatt, LS; Frenkel, N (1996). "In vitro activation of human herpesviruses 6 and 7 from latency" ( ... Nicholas, John (September 1996). "Determination and analysis of the complete nucleotide sequence of human herpesvirus 7" (PDF ... "Metagenomic analysis of double-stranded DNA viruses in healthy adults". BMC Biology. 12: 71. doi:10.1186/s12915-014-0071-7. ... A 2014 Washington University School of Medicine's analysis of 102 healthy adults sampled at as many as five major body habitats ...
Neutron activation analysis can be used to remotely detect the chemical composition of materials. This is because different ... link) Prompt Gamma-ray Neutron Activation Analysis. International Atomic Energy Agency D. Franklin; R. B. Adamson (1 January ...
Meinke, W. W.; Anderson, R. E. (1954). "Activation Analysis of Several Rare Earth Elements". Analytical Chemistry. 26 (5): 907- ... A larger amount of 154Eu is produced by neutron activation of a significant portion of the non-radioactive 153Eu; however, much ...
Neutron activation analysis, a nuclear process used for determining the concentrations of elements in materials ...
Fernandez, I.; Bickelhaupt, F. M. (2012). "Alder-ene reaction: Aromaticity and activation-strain analysis". Journal of ... By computationally examining both the activation barriers and the activation strains of several different ene reactions ... This translates into a lowering of the activation barrier until 14.7 kcal/mol (M06-2X/def2-TZVPP), if S replaces O on the ... a high activation barrier, which was approximated at 33 kcal/mol in the case of propene and ethene, as computed at the M06-2X/ ...
Wayman, Michael L. (1989). Neutron Activation Analysis of Metals: A Case Study. MASCA Research Papers in Science and ...
Reuter CW, Catling AD, Jelinek T, Weber MJ (March 1995). "Biochemical analysis of MEK activation in NIH3T3 fibroblasts. ... It then binds key activation loop and DFG motif residues to stop the movement of the activation loop and DFG motif to the ... During B-Raf activation, the protein's autoinhibitory CR1 domain first binds Ras-GTP's effector domain to the CR1 Ras-binding ... "Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF". Cell. 116 (6): 855-67. doi:10.1016/ ...
H. J. Born Activation analysis, Technical Report Number BMBW-FBK-72-13, 1st Seminar on Activation Analysis, 8 December 1970, ... 1, 29-43 (1973) H. J. Born and J. L. Kim Monostandard activation analysis and its applications: analyses of kale powder and NBS ... P. Wilkniss and H. J. Born On the Activation Analysis of Oxygen with Help of the Reaction O16 (T,n) F18, Intern. J. Appl. ... H. J. Born and D. C. Aumann Activation Analysis Determination of Lithium with the Help of the Reaction Chain 6Li (n,d) 3H and ...
Cuijpers, P.; Van Straten, A.; Warmerdam, L. (2007). "Behavioral activation treatments of depression: A meta-analysis". ... Behavioural activation (BA) is considered to be a traditional form of psychotherapy. It is based on activity scheduling and ... Cuijpers, P.; Van Straten, A.; Warmerdam, L. (2007). "Problem solving therapies for depression: A meta-analysis". European ... Cognitive Behavioural Therapy, Mindfulness-Based Cognitive Therapy, Behavioural Activation, Problem-Solving Therapy, Positive ...
"Analysis of essential elements in Pragya-peya-a herbal drink and its constituents by neutron activation". Journal of ... Pittler MH, Ernst E (2000). "Efficacy of kava extract for treating anxiety: systematic review and meta-analysis". Journal of ... Pharmaceutical and Biomedical Analysis. 37 (4): 631-828. doi:10.1016/j.jpba.2004.11.051. PMID 15797781.. ...
"Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting". ... Corrocher R, Tedesco F, Rabusin P, De Sandre G (1975). "Effect of human erythrocyte stromata on complement activation". Br. J. ... Lin B, Morris DW, Chou JY (1997). "The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation". ... "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A ...
The goal of fMRI data analysis is to detect correlations between brain activation and a task the subject performs during the ... The resulting brain activation can be graphically represented by color-coding the strength of activation across the brain or ... This 4 D volume is the starting point for analysis. The first part of that analysis is preprocessing. ... Statistical analysis[edit]. These fMRI images are from a study showing parts of the brain lighting up on seeing houses and ...
Office Genuine Advantage Windows Product Activation Digital rights management WGA dubbed Windows Activation Technologies with ... Analysis, Comments and Product Reviews for IT Professionals The Ed Bott Report , Page 221 , ZDNet Dvorak, John C. (October 16, ... In Windows 7, WGA is renamed Windows Activation Technologies. WGA consists of two components: an installable component called ... 2006). "Onerous Vista Activation-A Time Bomb?". PC Magazine. "Windows Genuine Advantage: A Ticking Time Bomb?". Fox News. ...
After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and ... Available sequence data analyses indicate splice variants that encode different isoforms. Carboxypeptidase B GRCh38: Ensembl ... Mosnier LO, Meijers JC, Bouma BN (2002). "The role of protein S in the activation of thrombin activatable fibrinolysis ... 1997). "The gene for human carboxypeptidase U (CPU)--a proposed novel regulator of plasminogen activation--maps to 13q14.11". ...
Jelinek HF, Karperien A, Bossomaier T, Buchan A (1975). "Differentiating grades of microglia activation with fractal analysis ... Activation of microglia places a load on the anabolic and catabolic machinery of the cells causing activated microglia to die ... Upon activation they rapidly uptake MHC class I/II proteins and quickly become efficient antigen presenters. In some cases, ... The activation of microglia and formation of ramified microglial clusters was first noted by Victor Babeş while studying a ...
Photon Activation for Archaeological Analysis at Idaho State University. Herbert D. G. Maschner, Buck Benson, Jaromy Green, and ... Photon Activation for Archaeological Analysis at Idaho State University. Proceedings of the 8th International Topical Meeting ... Reconstructing site organization in the eastern Aleutian Islands, Alaska, using multi‐element chemical analysis of soils. N. ... Maschner's research interests include complex systems analyses of the North Pacific Rim and Western North America, particularly ...
Bacon, K.B. (1997). "Analysis of signal transduction following lymphocyte activation by chemokines". Methods Enxymol. Methods ... 2001). "Activation of RhoA and ROCK are essential for detachment of migrating leukocytes". Mol. Biol. Cell. 12 (7): 2137-2145. ... The chemorepellent 8CPT-cAMP inhibits PLC activity and thereby increases Ptds(3,4,5)P3 accumulation and activation of PTEN. In ... 2003). "Stromal cell-derived factor 1-alpha stimulates human gliblastoma cell growth through the activation of both ...
... carbohydrate recognition and analysis of the b-prims fold". Protein Science. 8 (1): 13-24. doi:10.1110/ps.8.1.13. PMC 2144112. ... "Tyrosine 151 is part of the substrate activation binding site of bovine trypsin: identification by covalent labelling with p- ...
... ... Here I present a novel methodology for using prompt gamma activation analysis to measure the effective diffusivity of noble ... The noble gas concentration variations at its source were measured using prompt gamma activation analysis and later compared to ...
Water tracing with soluble metal chelates and neutron activation analysis : a laboratory and field study Public Deposited ... Research on the application of soluble, metal chelates for water tracing using thermal neutron activation analysis for tracer ... Activation procedures are feasible which decrease the minimum detection levels to 0.0015 ppb for Eu, 0.0019 ppb for Tb and ... A method evaluation and economic analysis clarify the potential application of activable metal chelates for water tracing. ...
Neutron Activation Analysis. Neutron Activation Analysis. Neutron activation analysis (NAA) is a precise analytical method, ...
Radio-isotope neutron activation analysis for vanadium, manganese and tungsten in alloy steels ... An instrumental neutron activation method for V, Mn and W in alloy steels with a 241 Am/Be isotopic neutron source is described ...
Instrumental neutron activation analysis and X-ray fluorescence on a pressed powder pellet, fused pellet or after a fusion were ... A one-way analysis of variance technique (ANOVAFootnote 1)and statistical analyses were used to assess the homogeneity of these ... and instrumental neutron activation analysis.. b The data generally includes sets by various fusions, and fused pellet or ... a Statistical analysis of the data warrants classification as provisional despite only 6 or 7 sets of data.. b Tthe data ...
Single-molecule imaging analysis of Ras activation in living cells. Hideji Murakoshi, Ryota Iino, Takeshi Kobayashi, Takahiro ... Single-molecule imaging analysis of Ras activation in living cells. Hideji Murakoshi, Ryota Iino, Takeshi Kobayashi, Takahiro ... Single-molecule imaging analysis of Ras activation in living cells Message Subject (Your Name) has sent you a message from PNAS ... Single-molecule imaging analysis of Ras activation in living cells. Hideji Murakoshi, Ryota Iino, Takeshi Kobayashi, Takahiro ...
Proteomic analysis of microtubule-associated proteins during macrophage activation.. Patel PC1, Fisher KH, Yang EC, Deane CM, ... Proteomic Analysis of Microtubule-associated Proteins during Macrophage Activation. Mol Cell Proteomics. 2009 Nov;8(11):2500- ... Proteomic Analysis of Microtubule-associated Proteins during Macrophage Activation. Mol Cell Proteomics. 2009 Nov;8(11):2500- ... Proteomic Analysis of Microtubule-associated Proteins during Macrophage Activation. Mol Cell Proteomics. 2009 Nov;8(11):2500- ...
The method of activation analysis not only increases the sensitivity for many trace elements1 but also eliminates the necessity ... for running blank analyses on the reagents since small amounts of impurities contained in the reagents will not be measured. ... Some Activation Analyses of Six Trace Elements in Marine Biological Ashes. *R. FUKAI1. ,2. nAff2 & ... The method of activation analysis not only increases the sensitivity for many trace elements1 but also eliminates the necessity ...
Data base analysis of protein expression patterns during T-cell ontogeny and activation.. S M Hanash, J R Strahler, Y Chan, R ... Data base analysis of protein expression patterns during T-cell ontogeny and activation. ... Data base analysis of protein expression patterns during T-cell ontogeny and activation. ... Data base analysis of protein expression patterns during T-cell ontogeny and activation. ...
Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.. Lou H1, Villagran G2, Boland JF3 ... Analysis of 675 tumors revealed activation of PIK3CA and other PI3K/AKT pathway genes in 31% of squamous carcinomas and 24% of ... Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway ... Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway ...
Results The global analysis included 15 studies concerning various solid tumors. For global analysis, FAP overexpression in ... Sensitivity analysis by FAP expression in different cells and tumor types were further subjected to sensitivity analyses as ... In this study, a meta-analysis was performed to clarify this issue. Methods A search of the PubMed, Embase and CNKI databases ... Second, the pooled analyses of colorectal cancers or pancreatic cancers all indicated that FAP overexpression was associated ...
Neutron activation analysis is used to measure bromide so that extraction is not necessary for analysis. NAA is used in geology ... this technique is known as Radiochemical Neutron Activation Analysis (RNAA). NAA can perform non-destructive analyses on solids ... Neutron activation analysis (NAA) is a nuclear process used for determining the concentrations of elements in a vast amount of ... Neutron activation analysis is also used to create standards in the semiconductor industry. Semiconductors require a high level ...
... Tumour Biol. 2014 Jun;35(6 ... and with IDH1-R132H mutation were examined by global metabolome analysis using capillary electrophoresis time-of-flight mass ...
Analysis of Posttranslational Activation of Alternative Oxidase Isoforms. Jennifer Selinski, Andreas Hartmann, Adrian Kordes, ... Analysis of Posttranslational Activation of Alternative Oxidase Isoforms. Jennifer Selinski, Andreas Hartmann, Adrian Kordes, ... Analysis of Posttranslational Activation of Alternative Oxidase Isoforms Message Subject (Your Name) has sent you a message ... Analysis of Posttranslational Activation of Alternative Oxidase Isoforms. Jennifer Selinski, Andreas Hartmann, Adrian Kordes, ...
on modern trends in activation analysis, Copenhagen, 1986, June 23-27 : Activation techniques ... Neutron activation analysis applied to the study of the composition of Cuban geological samples from petroleum ores [Text] : ... Proceedings of the 9th international conference on modern trends in activation analysis : MTAA-9,Sept.24-30,1995,Seoul,Korea ... Proceedings of the 9th international conference on modern trends in activation analysis : MTAA-9,Sept.24-30,1995,Seoul,Korea ...
Prompt-gamma neutron activation analysis (PGAA) is a very widely applicable technique for determining the presence and amount ... Harder, J. 2009, Material analysis for process control in cement plants, ZKG INTERNATIONAL, 6/7 - 2009, Volume 62, p. 64 http ...
... sup 232/Th in seawater has made possible rapid sampling and analysis of this long-lived, non-radiogenic thorium isotope on ... The recent development of neutron activation analysis and mass spectrometric methods for the determination of / ... Huh, Chih-An. Determination of thorium in seawater by neutron activation analysis and mass spectrometry, article, January 1, ... The recent development of neutron activation analysis and mass spectrometric methods for the determination of /sup 232/Th in ...
Integrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activation.. [Stefano de Pretis, Theresia R ... Here, we present an integrated time-course analysis of transcription and mRNA dynamics following MYC activation in ... Transcriptional activation correlated with the highest increases in MYC binding at promoters. Repression followed a reciprocal ... MYC activation elicited immediate loading of RNA polymerase II (RNAPII) at activated promoters, followed by increases in pause- ...
Previous meta-analyses suggest that during episodic memory tasks, MCI patients exhibit hyperactivation in the me … ... A Meta-Analysis of fMRI Activation Differences during Episodic Memory in Alzheimers Disease and Mild Cognitive Impairment J ... This quantitative meta-analysis re-examines the activation associated with episodic memory in AD and MCI as compared to ... A whole-brain activation likelihood estimation based meta-analysis was conducted on fMRI studies that examined episodic memory ...
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. Giulia Fabbri, Silvia Rasi, ... Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation ... Genome-wide SNP analysis. Analysis of the same 5 CLL samples (and paired normal DNAs) by the Affymetrix SNP 6.0 platform ... FISH analysis.. The following probes were used for FISH analysis of CLL and RS cases: LSID13S319, CEP12, LSIp53, LSIATM, LSI ...
In the activation analysis method, molybdate and tungstate ions are added to samples containing phosphate ion to form ... After activation of an aliquot of the organic phase for 1 hour at a flux of 1013 neutrons per cm2, per second, the gamma ... If the ratio of phosphorus to sulfur or chlorine is small, as it is in most natural waters, accurate analyses by these methods ... Activation analysis may be used to determine quantitatively traces of phosphate in natural waters. Methods based on the ...
Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation ... Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation ... Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation ... Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation ...
Abstract: A5.00002 : Single molecule analysis of B cell receptor motion during signaling activation. 8:36 AM-8:48 AM ... During activation, BCR form signaling microclusters that later coalesce as the cell contracts. We have studied the dynamics of ... B cell receptor (BCR) binding to antigen induces a signaling cascade that leads to B cell activation and spreading. ... The tracks are analyzed using perturbation expectation-maximization (pEM), a systems-level analysis, which allows ...
... catalogued clinically identified mutations in the ErbB family kinase domains on the molecular mechanisms of kinase activation. ...
  • Activation procedures are feasible which decrease the minimum detection levels to 0.0015 ppb for Eu, 0.0019 ppb for Tb and 0.0057 ppb for In in comparison to 0.075 ppb for Rhodamine B. Anion-exchange proved uniquely suited for recovery and concentration of metal-chelate tracers from natural water and as a low background irradiation and counting matrix. (oregonstate.edu)
  • The noble gas concentration variations at its source were measured using prompt gamma activation analysis and later compared to a numerical diffusion model to estimate the effective diffusion coefficient. (utexas.edu)
  • Along this second axis, combinations of conflicting stimuli, interleukin 4 (IL4) with lipopolysaccharide (LPS), interferon-γ (IFNγ), IFNβ, or tumor necrosis factor-α (TNFα), produced mutual inhibition of several signaling pathways, e.g. nuclear factor κB (NFκB) and signal transducer and activator of transcription 6 (STAT6), but also mutual activation of the phosphoinositide 3-kinases (PI3K) signaling module. (biorxiv.org)
  • Metabolic network‐based analyses identified well‐established critical metabolite effectors and intracellular pathways that impact activation or suppression of M1‐ and M2‐metabolic activation phenotypes. (embopress.org)
  • To understand the finely tuned process of neutrophil functioning in vivo, it is also necessary to define components of the signaling pathways responsible for the priming and activation of effector functions in granulocytes. (uu.nl)
  • The aims of our study were to investigate PIK3CA gene mutations on a large series of TNBC, to perform a wider analysis on genetic alterations involving PI3K/AKT and BRAF/RAS/MAPK pathways and to correlate the results with clinical-pathologic data. (uniss.it)
  • Deregulation of PI3K/AKT pathways was revealed by consistent activation of pAKT and p-p44/42 MAPK in all PIK3CA mutated TNBC. (uniss.it)
  • Analysis of microarray data demonstrated that the transcriptome of CD4 + CD154 + cells was distinct from that of CD154 - cells and showed major enrichment of transcripts encoding multiple cytokines and pathways of cellular activation. (elsevier.com)
  • A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver fibrosis, and an ordinary differential equation (ODE) model was published showing that the net activation of TGF-β1 depends on the balance between two antagonistic sub-pathways. (biomedcentral.com)
  • FLT3 mutations result in constitutive activation of the FLT3 receptor kinase in the absence of FLT3 ligand and abnormal activation of downstream signaling pathways, including signal transducer and activator of transcription 5 (STAT5), mitogen-activated protein kinase kinase (Mek)/extracellular signal-regulated kinase (Erk) and phosphatidylinositol-3 kinase (PI3K). (bloodjournal.org)
  • Progranulin biological responses elicit through the activation of the Akt and MAPK pathways, which are critical for progranulin downstream signaling. (elsevier.com)
  • abstract = "The primary aim of this investigation was to evaluate the effect of training on the immune activation in skeletal muscle in response to an acute bout of resistance exercise (RE). (elsevier.com)
  • Transcriptome analysis was performed in a subset of 14 of 50 Ewing sarcomas and DNA copy number gain and expression of FGFR1 in 63 of 116 Ewing sarcomas. (uzh.ch)
  • Analysis of Ag-specific CD4 + T cells in mycobacterial infections at the transcriptome level is informative but technically challenging. (elsevier.com)
  • While the number of studies eligible to be included in this meta-analysis was small, the results of this systematic review reveal that antisaccade and prosaccade trials consistently activate a distributed network of regions both within and outside the classic definition of the oculomotor network. (frontiersin.org)
  • 2-14 However, RRS activation in dialysis patients has not been studied before, and we hypothesised that such an analysis might reveal unique systemic problems. (bmj.com)
  • Specifically, we will conduct a structure-function analysis of the ethanol-binding pocket in GIRK2/3 channels (1), solve high-resolution structures of GIRK channels complexed with ethanol to reveal conformational changes in the channel protein that occur with ethanol-dependent gating (2), and elaborate mechanistic models for ethanol-dependent activation of GIRK channels, utilizing single-channel recordings and chemical modification of cysteine-substituted channels (3). (grantome.com)
  • These mechanisms have been reported that treatment with statins results in lowering intracellular cholesterol concentration, and then increasing a proteolytic activation of sterol responsive element-binding proteins (SREBPs) [ 1 ]. (hindawi.com)
  • Global cardiac ischaemia was simulated by (i) decreased intracellular ATP concentration and subsequent activation of an ATP sensitive K⁺ current, (ii) elevated extracellular K⁺ concentration, and (iii) acidosis resulting in reduced magnitude of the L-type Ca²⁺ current I(Ca,L). Simulated ischaemia acted to shorten action potential duration, reduce conduction velocity, increase effective refractory period, and flatten restitution. (ox.ac.uk)
  • Taken together, our results demonstrate that AOX isoforms are differentially activated and that activation at CysI and CysII is additive. (plantphysiol.org)
  • The question as to whether the biological activities of TSST-1, e.g., lymphocyte extravasation, toxicity and increased sensitivity to LPS, are mediated by T cell activation or activation by MHC II-only, are unresolved and results are contradictory. (mdpi.com)
  • Our results strongly suggest that long-distance activation in S. cerevisiae is normally limited by Sin4 and other factors and that this constraint plays a role in ensuring UAS-core promoter specificity in the compact S. cerevisiae genome. (asm.org)
  • Taken together, these results indicate that the increased intensity of the apoptotic phenomenon in HIV infection is caused by the general state of immune activation, and is independent of the progression of HIV disease and of the levels of viral load. (jimmunol.org)
  • Results Over a 64-month-period, 107 of 8928 patients undergoing haemodialysis on the dialysis unit required an RRS activation (12 events/1000 patients dialysed). (bmj.com)
  • RESULTS: In total, six studies of uTAP with a cut-off value of 35 nmol/L were included in this meta-analysis. (pubmedcentralcanada.ca)
  • Though experimental results have shown the transitions between these two types of macrophages, little is known about the dynamic progression of macrophages activation. (biomedcentral.com)
  • The results support the previous knowledge that DAG/PKC signalling is involved in mediating processes important for T cell activation. (uta.fi)
  • Therefore, in the present study, we performed a meta-analysis on the results of studies reporting grey matter abnormalities in TS patients. (researchsquare.com)
  • The results demonstrate that tight complementarity of the protein sequences is necessary for NS2B-dependent activation of NS3. (pasteur.fr)
  • The results also determine residues in the ALKV NS2B cofactor essential for protease activation, giving new insights into protease function in flaviviruses. (pasteur.fr)
  • Exposure of neutrophils to cytokines or chemokines, results in their activation and changes in gene expression profiles. (uu.nl)
  • Our results support the use of CD154 expression as a practical and reliable method to isolate live Ag-specific CD4 + T cells for transcriptomic analysis and potentially for a range of other studies in infected or previously immunized hosts. (elsevier.com)
  • These results indicate that adult neurogenesis occurs in the tree shrew dentate gyrus and is regulated by a stressful experience and NMDA receptor activation. (jneurosci.org)
  • These results suggest that continuous activation of the brain renin-angiotensin system impairs cognitive function via stimulation of the angiotensin II type 1 receptor with a decrease in cerebral surface blood flow and an increase in oxidative stress. (ahajournals.org)
  • Results show that p53 activation in stroma cells blunts stroma cell-mediated resistance to FLT3 inhibition, in part through down-regulation of CXCL12. (bloodjournal.org)
  • On the basis of these results, we hypothesize that rapid activations from these structures may also play roles in the formation of sustained AF in vivo. (ahajournals.org)
  • These results indicate that acute administration of rapamycin in trout leads to the inhibition of TORC1 activation. (biologists.org)
  • Frequency analysis of right ventricular (RV) epicardial activation obtained from a 64-channel multi-electrode array demonstrated greater prominence of late conducting components in Scn5a(+/-) compared to WT male, and in male compared to female Scn5a(+/-) following stratification by genotype and sex. (surrey.ac.uk)
  • Experiment-model interaction for analysis of epicardial activation during human ventricular fibrillation with global myocardial ischaemia. (ox.ac.uk)
  • The observation that the existing snf mutations present a lethal phenotype only in certain genetic backgrounds suggests that snf is required, but is not essential, for the activation of Sex-lethal in the soma. (genetics.org)
  • Mutations that suppressed RetGC activation by GCAP1 produced different effects on the ability of the mutant GUCY2D to bind GCAP1-GFP in HEK 293 cells: some of them suppressed GCAP1 GFP binding while the others had no effect on the binding and evidently caused the loss of GUCY2D activity in vitro through affecting its catalytic activity per se. (arvojournals.org)
  • Our data shows that PIK3CA mutations and PI3K/AKT pathway activation are common events in TNBC. (uniss.it)
  • In addition to the elemental and isotopic analysis of samples, INAA permits the analysis of non-radioactive tracers introduced into biological, chemical, and/or industrial processes for process identification and optimization. (ncsu.edu)
  • Is the Subject Area "Meta-analysis" applicable to this article? (plos.org)
  • AIM: To undertake a meta-analysis on the value of urinary trypsinogen activation peptide (uTAP) in predicting severity of acute pancreatitis on admission. (pubmedcentralcanada.ca)
  • Our present meta-analysis primarily revealed significant increases in grey matter volumes in the thalamus and lentiform nucleus, and decreased grey matter volumes in the anterior cingulate gyrus, of TS patients compared to those in healthy controls. (researchsquare.com)
  • Activation strain analyses for the oxidative addition of methane to Ni(PH3)2, Pd(PH3)2, and Pt(PH3)2. (nih.gov)
  • Conclusion- High P i itself elicits arterial O 2 ·− production, most likely by PKC-dependent activation of NAD(P)H oxidase, thus providing a potential explanation for the presence of oxidative stress and endothelial dysfunction in various forms of hypertension and the vasculoprotective effect of antihypertensive agents of different mechanisms of action. (ahajournals.org)
  • The genetic analysis of snf: a Drosophila sex determination gene required for activation of Sex-lethal in both the germline and the soma. (genetics.org)
  • In the soma, activation of Sex-lethal appears to be sensitive to snf gene dosage only when the probability of Sex-lethal activation has been otherwise reduced. (genetics.org)
  • In S. cerevisiae , upstream activation sequences (UASs) are generally located within a few hundred base pairs of a target gene, while in Drosophila and mammals, enhancers are often several kilobases away. (asm.org)
  • As the S. cerevisiae genome is compact, and the majority of yeast promoters range from approximately 150 to 400 bp ( 28 , 59 ), it seems logical that there would be restrictions on activation distance in order to maintain specificity between a UAS and its target gene. (asm.org)
  • To elucidate the first steps of sexual fate specification, we profiled the XX and XY gonad transcriptomes at fine granularity during this period and resolved cascades of gene activation and repression. (sigmaaldrich.com)
  • VDR is induced by p53 as well as several other p53 family members, and analysis of chromatin immunoprecipitation showed that p53 protein binds to conserved intronic sequences of the VDR gene in vivo . (aacrjournals.org)
  • Background and aims: Protein kinases C (PKC) and A (PKA) are central signalling molecules in T cell activation and are involved in regulating gene expression. (uta.fi)
  • We examined the possibility that continuous activation of the human brain renin-angiotensin system causes cognitive impairment, using human renin (hRN) and human angiotensinogen (hANG) gene chimeric transgenic (Tg) mice. (ahajournals.org)
  • The findings that excreted pTECs demonstrate activated NF-κB and IL-6 antigen and that AGE-albumin and CML lead to a perpetuated activation of NF-κB in vitro infer that a perpetuated increase in proinflammtory gene products, such as IL-6, plays a role in damaging the renal tubule. (diabetesjournals.org)
  • Complement activation is regulated by a complex group of membrane-bound and fluid-phase proteins ( 1 ). (pnas.org)
  • Factor H is an abundant serum complement regulatory protein that inhibits the alternative pathway of complement activation. (pnas.org)
  • The experimental data for receptor activation by agonist combinations were in agreement with the established views of the overlap of binding sites for several pairs of orthosteric (GABA, β -alanine, and piperidine-4-sulfonic acid) and/or allosteric agents (propofol, pentobarbital, and several neuroactive steroids). (aspetjournals.org)
  • These studies were designed to determine whether adult neurogenesis occurs in the dentate gyrus of the tree shrew, an animal phylogenetically between insectivores and primates, and to explore the possibility that this process is regulated by stressful experiences and NMDA receptor activation. (jneurosci.org)
  • The goal of this grant is to investigate the molecular and structural mechanisms underlying ethanol-dependent activation of neuronal potassium channels. (grantome.com)
  • Different sarcoma subtypes demonstrated distinct oncogenic pathway activation patterns, and reclassified MFH tumors shared oncogenic pathway activation patterns with their predicted subtypes. (harvard.edu)
  • Conclusions/Significance: STS profiling can aid in diagnosis through a predictor tracking distinct tissue differentiation in unclassified tumors, and in therapeutic management via oncogenic pathway activation and chemotherapy response assessment. (harvard.edu)
  • On activation, Ras diffusion was greatly suppressed/immobilized, suggesting the formation of large, activated Ras-signaling complexes. (pnas.org)
  • During activation, BCR form signaling microclusters that later coalesce as the cell contracts. (aps.org)
  • Several genetically encoded fluorescent biosensors for Ras family GTPases have been developed that permit spatiotemporal analysis of the activation of these signaling molecules in living cells. (semanticscholar.org)
  • At the molecular level, SIRT6-mediated autophagy was triggered by an increase of ROS levels, which, in turn, resulted in the activation of the AMPK-ULK1-mTOR signaling pathway. (nature.com)
  • Hence, insulin signaling bifurcates downstream of PI 3-kinase, one arm leading to actin remodeling and another to Akt activation, both converging to promote GLUT4 translocation. (diabetesjournals.org)
  • Background: In this study, the effect of antigen-presenting cells (APC), peptide concentration, and CD28 costimulation on calcium signaling, induced by antigen-specific T-cell activation, was studied by flow cytometry. (elsevier.com)
  • However, there is no clear understanding of the effect of distance on activation in S. cerevisiae in vivo and no knowledge concerning factors that might play a role in controlling this effect. (asm.org)
  • Specifically, activation maps and bipolar voltages were recorded in vivo from 6 pigs at ~5 weeks following infarct creation, as well as 6 control (normal) pigs. (springer.com)
  • Its critical importance as a regulator of C3 activation in vivo is illustrated by the complement profile reported in factor H-deficient individuals, where alternative pathway activation proceeds unhindered, resulting in markedly reduced C3 levels ( 4 ). (pnas.org)
  • AGE-albumin) and in particular carboxymethyllysine (CML) are known to play a central role in diabetic nephropathy, we studied the activation of nuclear factor κB (NF-κB) in tubular epithelial cells in vivo and in vitro by AGE-albumin and CML. (diabetesjournals.org)
  • The data suggested that WSSV infection triggers the activation of NEI in shrimp, which throws a light on the pivotal roles of NEI system mediated by hemocytes in shrimp antiviral immunity. (springer.com)
  • The latter triggers activation of several serine/threonine kinases, notably Akt, which, through its substrate AS160, regulates GLUT4 vesicle mobilization to and/or fusion with the plasma membrane ( 2 ). (diabetesjournals.org)
  • Analysis of Ras activation in living cells with GFP-RBD. (semanticscholar.org)
  • Analysis of activation of OVA-specific T cells. (nih.gov)
  • The regulation by the infused T cells impeded the development of fully competent OVA-specific effector/memory Th2 lymphocytes without inhibiting the initial proliferative response of T cells or promoting activation-induced cell death. (nih.gov)
  • Early T cell activation and proliferation was assessed by the counting of OVA-specific T cells, the determination of cell size, the expression of early activation markers such as CD25 and CD69, and the rate of cell division. (nih.gov)
  • Measurement of activation-induced expression of CD154 has been reported to detect live Ag-specific CD4 + T cells, but this approach remains underexplored and, to our knowledge, has not previously been applied in mycobacteria-infected animals. (elsevier.com)
  • p53 activation by Nutlin-3a was not cytotoxic to stromal cells, but reduced CXCL12 mRNA levels and secretion of CXCL12 partially through p53-mediated HIF-1α down-regulation. (bloodjournal.org)
  • The paper also proposed a novel way to accelerate the phenotypic transition from persister cells to normally growing cell under resonance activation. (vt.edu)
  • Hope (goal-directed thinking) and patient activation (knowledge and skills to manage one's illness) are both important in managing chronic conditions like schizophrenia. (iupui.edu)
  • However, because the activation patterns in chronic pacing-induced sustained AF are not well defined, it is unclear whether reentry is present in pacing-induced AF. (ahajournals.org)
  • Immunoblotting is described for following the activation of specific caspases. (elsevier.com)
  • Finally, sustained activation of SIRT6 resulted in autophagy-related cell death, a process that was markedly attenuated using either a pan caspases inhibitor (zVAD-fmk) or an autophagy inhibitor (CQ). (nature.com)
  • A comparative analysis of the AOX isoenzymes AOX1A, AOX1C, and AOX1D from Arabidopsis ( Arabidopsis thaliana ) revealed that cysteine residues, CysI and CysII, are both involved in 2-oxo acid activation, with AOX1A activity being more increased by 2-oxo acids than that of AOX1C and AOX1D. (plantphysiol.org)
  • A comparative genomic analysis of putative p53 binding sequences may thus be a way to identify the downstream mediators of p53 function. (aacrjournals.org)
  • Comparative analysis of GUCY2D activity and its ability to bind GCAP1-GFP in a cell-based assay provides a useful tool for distinguishing between the direct suppression of GUCY2D activity versus that of GCAP1 or RD3 binding. (arvojournals.org)
  • In this study, we evaluated different advanced CID techniques (i.e., neutral-loss triggered MS3 and multi-stage activation) during LC-MSn analyses of Amadori-modified peptides enriched from human serum glycated in vitro. (unt.edu)
  • GUCY2D activation by GCAP1 expressed in E. coli was measured in vitro . (arvojournals.org)
  • 7 8 9 We 10 have previously demonstrated that the LOM in dogs with long-term rapid pacing serves as a source of rapid activations and may contribute to the development of AF in vitro. (ahajournals.org)
  • Like Akt activation, Rac-GTP loading was largely prevented by inhibitors of PI 3-kinase, suggesting that Akt and Rac are downstream effectors of PI 3-kinase involved in insulin-induced GLUT4 translocation. (diabetesjournals.org)
  • Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway. (nih.gov)
  • On these grounds, we have exploited an integrated approach based on next generation whole-exome sequencing (WES) and genome-wide high-density single-nucleotide polymorphism (SNP) analysis to investigate the CLL coding genome. (rupress.org)
  • We applied a Fab-based live endogenous modification labeling technique to monitor the changes in histone modification levels during zygotic genome activation (ZGA) in living zebrafish embryos. (biologists.org)
  • We constructed a genome‐scale metabolic network for the RAW 264.7 cell line to determine metabolic modulators of activation. (embopress.org)
  • We analyzed several independent microarray datasets, to identify a predictor, use it to classify unclassifiable sarcomas, and assess oncogenic pathway activation and chemotherapy response. (harvard.edu)
  • Bayesian models of oncogenic pathway activation and chemotherapy response were applied to individual STS samples. (harvard.edu)
  • Functional relevance of the observed NF-κB activation was demonstrated in pTECs transfected with a NF-κB-driven luciferase reporter plasmid and was associated with an increased release of IL-6 into the supernatant. (diabetesjournals.org)