DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Puma: A genus in the family FELIDAE comprising one species, Puma concolor. It is a large, long-tailed, feline of uniform color. The names puma, cougar, and mountain lion are used interchangeably for this species. There are more than 20 subspecies.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cyclic AMP Response Element-Binding Protein: A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.Colonic Neoplasms: Tumors or cancer of the COLON.HCT116 Cells: Human COLORECTAL CARCINOMA cell line.bcl-2 Homologous Antagonist-Killer Protein: A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.Cell Line, Tumor: A cell line derived from cultured tumor cells.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Cell Dedifferentiation: A reverse developmental process in which terminally differentiated cells with specialized functions revert back to a less differentiated stage within their own CELL LINEAGE.Acinar Cells: Cells lining the saclike dilatations known as acini of various glands or the lungs.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Pancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Toll-Like Receptors: A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Toll-Like Receptor 4: A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.Toll-Like Receptor 2: A pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.Toll-Like Receptor 9: A pattern recognition receptor that binds unmethylated CPG CLUSTERS. It mediates cellular responses to bacterial pathogens by distinguishing between self and bacterial DNA.Immunity, Innate: The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.Toll-Like Receptor 3: A pattern recognition receptor that binds DOUBLE-STRANDED RNA. It mediates cellular responses to certain viral pathogens.Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Immediate-Early Proteins: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Helping Behavior: Behaviors associated with the giving of assistance or aid to individuals.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
(1/272) Transcriptional autorepression of the stress-inducible gene ATF3.

Previously, we demonstrated that ATF3 (activating transcription factor-3) is a stress-inducible gene, and the protein it encodes is a transcriptional repressor. In this report, we present evidence suggesting that ATF3 represses the transcription of its own gene. Interestingly, efficient repression requires a consensus ATF/cAMP-responsive element site in the promoter and a previously unidentified ATF3-binding site immediately downstream from the TATA box. Although this new site resembles the known ATF/cAMP-responsive element sequences at the flanking sequence, it differs from them at the center key residues. These observations indicate that ATF3 can tolerate variations in the center of the binding sites if the flanking sequences are favorable. The repression of the ATF3 promoter by its own gene product provides a mechanistic explanation, at least in part, for the transient expression pattern of the ATF3 gene upon stress induction.  (+info)

(2/272) Injury-specific expression of activating transcription factor-3 in retinal ganglion cells and its colocalized expression with phosphorylated c-Jun.

PURPOSE: To ascribe activating transcription factor (ATF)-3 as a specifically induced transcription factor after ON injury and to describe its putative role as a modulator of c-Jun transactivation. METHODS: The adult rat optic nerve was crushed intraorbitally, and expression profiles of ATF-3, ATF-2, and phosphorylated c-Jun (p-c-Jun) were examined by immunohistochemistry and ISH. Western blot analysis for ATF-3 and -2 were also performed. Furthermore, colocalized detection of c-Jun mRNA with ATF-2 or -3 was attempted with a combined method of simultaneous immunohistochemistry and in situ hybridization. RESULTS: In response to optic nerve injury, substantial expression of ATF-3 as well as that of p-c-Jun was observed in the retinal ganglion cells, whereas no expression of ATF-3 was seen in other noninjured retinal cells. In contrast, ATF-2 was normally expressed abundantly in both retinal ganglion cells and displaced amacrine cells, but expression dropped in retinal ganglion cells after nerve injury. The expression profiles of ATF-2 and -3 after optic nerve injury were confirmed by Western blot analysis. A higher degree of colocalization was observed for ATF-3 and c-Jun than the modest codetection for ATF-2 and c-Jun. CONCLUSIONS: The transcription factor ATF-3 is specifically induced upon optic nerve injury and colocalizes with p-c-Jun in surviving ganglion cells. These findings suggest that both ATF-3 and c-Jun are crucial to trigger various transcriptional responses and may act synergistically during the survival phase of the optic nerve in the injury model.  (+info)

(3/272) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element.

Activating transcription factor (ATF) 3 is a member of ATF/cyclic adenosine monophosphate (cAMP)-responsive element binding protein (ATF/CREB) family of transcription factors and functions as a stress-inducible transcriptional repressor. To understand the stress-induced gene regulation by homocysteine, we investigated activation of the ATF3 gene in human endothelial cells. Homocysteine caused a rapid induction of ATF3 at the transcriptional level. This induction was preceded by a rapid and sustained activation of c-Jun NH(2)-terminal kinase/stress-activated protein kinase (JNK/SAPK), and dominant negative mitogen-activated protein kinase kinase 4 and 7 abolished these effects. The effect of homocysteine appeared to be specific, because cysteine or homocystine had no appreciable effect, but it was mimicked by dithiothreitol and beta-mercaptoethanol as well as tunicamycin. The homocysteine effect was not inhibited by an active oxygen scavenger. Deletion analysis of the 5' flanking sequence of the ATF3 gene promoter revealed that one of the major elements responsible for the induction by homocysteine is an ATF/cAMP responsive element (CRE) located at -92 to -85 relative to the transcriptional start site. Gel shift, immunoprecipitation, and cotransfection assays demonstrated that a complex (or complexes) containing ATF2, c-Jun, and ATF3 increased binding to the ATF/CRE site in the homocysteine-treated cells and activated the ATF3 gene expression, while ATF3 appeared to repress its own promoter. These data together suggested a novel pathway by which homocysteine causes the activation of JNK/SAPK and subsequent ATF3 expression through its reductive stress. Activation of JNK/SAPK and ATF3 expression in response to homocysteine may have a functional role in homocysteinemia-associated endothelial dysfunction.  (+info)

(4/272) High-mobility-group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus type 1 proviral promoter.

HMG I/Y appears to be a multifunctional protein that relies on in its ability to interact with DNA in a structure-specific manner and with DNA, binding transcriptional activators via distinct protein-protein interaction surfaces. To investigate the hypothesis that HMG I/Y may have a role in human immunodeficiency virus type 1 (HIV-1) expression, we have analyzed whether HMG I/Y interacts with the 5' long terminal repeat and whether this interaction can modulate transcription factor binding. Using purified recombinant HMG I, we have identified several high-affinity binding sites which overlap important transcription factor binding sites. One of these HMG I binding sites coincides with an important binding site for AP-1 located downstream of the transcriptional start site, in the 5' untranslated region at the boundary of a positioned nucleosome. HMG I binding to this composite site inhibits the binding of recombinant AP-1. Consistent with this observation, using nuclear extracts prepared from Jurkat T cells, we show that HMG I (but not HMG Y) is strongly induced upon phorbol myristate acetate stimulation and this induced HMG I appears to both selectively inhibit the binding of basal DNA-binding proteins and enhance the binding of an inducible AP-1 transcription factor to this AP-1 binding site. We also report the novel finding that a component present in this inducible AP-1 complex is ATF-3. Taken together, these results argue that HMG I may play a fundamental role in HIV-1 expression by determining the nature of transcription factor-promoter interactions.  (+info)

(5/272) Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation.

Nrf2 regulates expression of genes encoding enzymes with antioxidant (e.g. heme oxygenase-1 (HO-1)) or xenobiotic detoxification (e.g. NAD(P)H:quinone oxidoreductase, glutathione S-transferase) functions via the stress- or antioxidant-response elements (StRE/ARE). Nrf2 heterodimerizes with small Maf proteins, but the role of such dimers in gene induction is controversial, and other partners may exist. By using the yeast two-hybrid assay, we identified activating transcription factor (ATF) 4 as a potential Nrf2-interacting protein. Association between Nrf2 and ATF4 in mammalian cells was confirmed by co-immunoprecipitation and mammalian two-hybrid assays. Furthermore, Nrf2.ATF4 dimers bound to an StRE sequence from the ho-1 gene. CdCl(2), a potent inducer of HO-1, increased expression of ATF4 in mouse hepatoma cells, and detectable induction of ATF4 protein preceded that of HO-1 (30 min versus 2 h). A dominant-negative mutant of ATF4 inhibited basal and CdCl(2)-stimulated expression of a StRE-dependent/luciferase fusion construct (pE1-luc) in hepatoma cells but only basal expression in mammary epithelial MCF-7 cells. A dominant mutant of Nrf2 was equally inhibitory in both cell types in the presence or absence of CdCl(2). These results indicate that ATF4 regulates basal and CdCl(2)-induced expression of the ho-1 gene in a cell-specific manner and possibly in a complex with Nrf2.  (+info)

(6/272) Compensatory hepatic regeneration after mild, but not fulminant, intraperitoneal sepsis in rats.

Sepsis is the leading cause of death in surgical intensive care units. Although both mild sepsis secondary to cecal ligation and single puncture (CLP) and fulminant, double puncture CLP (2CLP) may provoke hepatocyte death, we hypothesize that regeneration compensates for cell death after CLP but not 2CLP. In male Sprague-Dawley rats, hepatic necrosis, as determined by serum alpha-glutathione S-transferase (alpha-GST) levels, was significantly but equally elevated over time after both CLP and 2CLP. Apoptosis, evaluated using both terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and morphological examination, was minimal after both CLP and 2CLP. Regeneration, assayed by staining tissue for incorporation of exogenously administered bromodeoxyuridine, was present after CLP but not after 2CLP. To further substantiate impaired regeneration, steady-state levels of mRNAs encoding JunB, LRF-1, and cyclin D1 were determined. After 2CLP, the absence of JunB, LRF-1, and cyclin D1 mRNAs confirmed failed activation of the mitogen-activated protein kinase-linked proliferative pathway and progression through the cell cycle. Therefore, failed hepatocyte regeneration may be a manifestation of hepatic dysfunction in fulminant sepsis.  (+info)

(7/272) Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation.

Activating Transcription Factor 3 (ATF3) is a member of the bZip family of transcription factors. Previous studies in mammalian cells suggested that like other bZip family members e.g. Jun and Fos, ATF3 might play a role in the control of cell proliferation and participate in oncogenic transformation. To investigate this putative ATF3 function directly, the rat ATF3 protein was compared with v-Jun for its ability to transform primary cultures of chick embryo fibroblasts (CEFs). Like CEFs accumulating v-Jun, CEFs accumulating the ATF3 protein displayed a typical, fusiform morphology, associated with an enhanced capacity to grow in medium with reduced amount of serum. However, in contrast to v-Jun-transformed CEFs, the ATF3 overexpressing cells could not promote colony formation from single cells in agar. Partial transformation induced by ATF3 was found to be associated with repression of multiple cellular genes that are also down-regulated by v-Jun, including those coding for the extracellular components fibronectin, decorin, thrombospondin 2, and the pro-apoptotic protein Par-4. These data demonstrate that, at least in primary avian cells, rat ATF3 possesses an intrinsic oncogenic potential. Moreover, the results suggest that ATF3 might induce growth factor independence by down-regulating a subset of the genes repressed by v-Jun.  (+info)

(8/272) The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas.

Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP-response element-binding protein family of transcription factors. It is a transcriptional repressor, and the expression of its corresponding gene is induced by stress signals in a variety of tissues, including the liver. In this report, we demonstrate that ATF3 is induced in the pancreas by partial pancreatectomy, streptozotocin treatment, and ischemia coupled with reperfusion. Furthermore, ATF3 is induced in cultured islet cells by oxidative stress. Interestingly, transgenic mice expressing ATF3 in the liver and pancreas under the control of the transthyretin promoter have defects in glucose homeostasis and perinatal lethality. We present evidence that expression of ATF3 in the liver represses the expression of genes encoding gluconeogenic enzymes. Furthermore, expression of ATF3 in the pancreas leads to abnormal endocrine pancreas and reduced numbers of hormone-producing cells. Analyses of embryos indicated that the ATF3 transgene is expressed in the ductal epithelium in the developing pancreas, and the transgenic pancreas has fewer mitotic cells than the non-transgenic counterpart, providing a potential explanation for the reduction of endocrine cells. Because ATF3 is a stress-inducible gene, these mice may represent a model to investigate the molecular mechanisms for some stress-associated diseases.  (+info)

*  CREB in cognition
The cellular transcription factor CREB (cAMP response element-binding protein) helps learning and the stabilization and ... this inducible transgenic system is that the altered protein is constitutively present and can therefore be rapidly activated ... Likewise, the lacZ mice that were trained with a tone protocol showed higher levels of CREB-dependent gene transcription in the ... showed higher levels of CREB-mediated transcription in the CA1 and CA3 regions of the hippocampus when compared to untrained ...
*  ATF3
Activating transcription factor ATF3 has been shown to interact with: C-jun, DDIT3 JunD, P53, and SMAD3. GRCh38: Ensembl ... "Entrez Gene: ATF3 activating transcription factor 3". Chen BP, Wolfgang CD, Hai T (Mar 1996). "Analysis of ATF3, a ... Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding ... Chu HM, Tan Y, Kobierski LA, Balsam LB, Comb MJ (January 1994). "Activating transcription factor-3 stimulates 3',5'-cyclic ...
*  Gene isoform
Activating transcription factor 3 (Atf3) is a known RAG with numerous promoters. Atf3 expression increases after nerve injury ... Cis-regulatory elements in the promoter contain sequences recognized by transcription factors and the basal transcription ... For example, the same transcription factor (TF) can direct gene expression in different tissues simply by binding with ... predicting interaction between transcription factors in human tissues". Nucleic Acids Res. 34 (17): 4925-36. doi:10.1093/nar/ ...
*  JunD
"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143-52. doi: ... "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143-52. doi: ... Chu HM, Tan Y, Kobierski LA, Balsam LB, Comb MJ (January 1994). "Activating transcription factor-3 stimulates 3',5'-cyclic ... Chu HM, Tan Y, Kobierski LA, Balsam LB, Comb MJ (1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine ...
*  KLF4
Krüppel-like factor 4, and activating transcription factor 3". Cancer Prevention Research. 4 (1): 116-27. doi:10.1158/1940-6207 ... Kruppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a zinc-finger transcription factor, and it was first ... Black AR, Black JD, Azizkhan-Clifford J (August 2001). "Sp1 and krüppel-like factor family of transcription factors in cell ... "Developmental and cell type-specific expression of the zinc finger transcription factor Krüppel-like factor 4 (Klf4) in ...
*  DRG1
2007). "The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in ... 1491 (1-3): 196-204. doi:10.1016/s0167-4781(00)00025-7. PMID 10760581. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ... doi:10.1016/s0167-4889(98)00129-3. PMID 9824680. Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human ...
*  Activating transcription factor 2
... , also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene. This gene ... Activating transcription factor 2 has been shown to interact with C-jun, Casein kinase 2, alpha 1, CREB binding protein, ... "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in ... Activating transcription factor GRCh38: Ensembl release 89: ENSG00000115966 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
*  Jun dimerization protein
It was later identified by the yeast-two hybrid system to bind to activating transcription factor 2 (ATF2) to repress ATF- ... "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in ... JDP2 (gene) has been shown to interact with Activating transcription factor 2. GRCh38: Ensembl release 89: ENSG00000140044 - ... c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter". ...
*  HDAC3
... suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression". J. Immunol. 173 (6 ... Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell ... Shi Y, Hon M, Evans RM (March 2002). "The peroxisome proliferator-activated receptor delta, an integrator of transcriptional ... Histone deacetylases can be regulated by endogenous factors, dietary components, synthetic inhibitors and bacteria-derived ...
*  MAPK11
This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ... suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression". J. Immunol. 173 (6 ... Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated ... a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein ...
*  CAMP responsive element modulator
Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... CREM transcription factors also play an important role in many physiological systems, such as cardiac function, circadian ... This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular ... Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". ...
*  SPI1
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell ... "The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in ... Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the ... "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838-42. doi: ...
*  TLR4
TRAM-TRIF signals activate the transcription factor Interferon Regulatory Factor-3 (IRF3) via TRAF3. IRF3 activation induces ... Transforming growth factor-β-Activated Kinase 1) that leads to the activation of MAPK cascades (Mitogen-Activated Protein ... while activation of MAPK cascades lead to the activation of another transcription factor AP-1. Both of them have a role in the ... signaling pathway leads to the induction of the transcription factor NF-κB, ...
*  Embryonal fyn-associated substrate
Activating transcription factor), NF-κβ, NF-κβ1, GATA-3, C/EBPα (CCAAT/enhancer-binding protein alpha), glucocorticoid ... Reciprocally, EFS activates SRC signaling through c-CRK and RAP1. Further, SRC directly phosphorylates residues Y576 and Y577 ... a guanine nucleotide exchange factor (GEF) for RAP1. PTP-PEST, a soluble protein tyrosine phosphatase that is ubiquitously ... is crucial for their functional maturation and growth factor-mediated expansion. mTECs are important for proper T-cell ...
*  ATF1
1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation". J. Biol. Chem. ... Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein ... This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper ... This gene has a pseudogene on chromosome 6. Activating transcription factor ATF1 has been shown to interact with: BRCA1, ...
*  IRF3
SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of ... is an interferon regulatory factor. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was ... This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other ... activation of a transcription factor complex containing IRF-3 and CBP/p300". EMBO J. 17 (4): 1087-95. doi:10.1093/emboj/17.4. ...
*  Prostate cancer
AR, an androgen-activated transcription factor, belongs to the steroid nuclear receptor family. Development of the prostate is ... RUNX2 is a transcription factor that prevents cancer cells from undergoing apoptosis thereby contributing to the development of ... Recent studies demonstrated the involvement of growth factors, such as epidermal growth factor (EGF) and neurotensin in the 5- ... Other factors that may be involved include a diet high in processed meat, red meat, or milk products or low in certain ...
*  MEF2D
"Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)". Youn HD, Liu JO (Jul ... with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771-7. doi:10.1093/nar/26.20.4771. PMC ... Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor ... Lu J, McKinsey TA, Nicol RL, Olson EN (Apr 2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation ...
*  Cholecystokinin
Calcineurin will go on to activate the transcription factors NFAT 1-3, which will stimulate hypertrophy and growth of the ... This modification is crucial for the ability of CCK to activate the cholecystokinin A receptor. Nonsulfated CCK peptides also ... Gurda GT, Guo L, Lee SH, Molkentin JD, Williams JA (January 2008). "Cholecystokinin activates pancreatic calcineurin-NFAT ... Liddle RA (September 1995). "Regulation of cholecystokinin secretion by intraluminal releasing factors". The American Journal ...
*  EIF5B
"Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene". ... Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation ... The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are ... Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene. Accurate initiation of ...
*  Interleukin 2
It cooperates with other transcription factors including NFkB and Oct. NFkB is translocated to the nucleus after costimulation ... PLC activates 3 major transcription factors and their pathways: NFAT, NFkB and AP-1. After costimulation from CD28 the optimal ... The key factor was isolated from cultured mouse cells in 1979 and from cultured human cells in 1980. The gene for human IL-2 ... activated with IL-2, then reinfused. Novartis acquired Chiron in 2006 and sold the aldesleukin business to Prometheus ...
*  TFAP2B
"Entrez Gene: transcription factor AP-2 beta (activating enhancer binding protein 2 beta)". Tsukada S, Tanaka Y, Maegawa H, et ... 2006). "Transcription factor activating enhancer-binding protein-2beta. A negative regulator of adiponectin gene expression". J ... Transcription factor AP-2 beta also known as AP2-beta is a protein that in humans is encoded by the TFAP2B gene. AP-2 beta is a ... 2009). "The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents". Obesity ( ...
*  ATF7
"Entrez Gene: ATF7 activating transcription factor 7". Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006 ... a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers". J ... Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene. In 2001, Peters et al ... "Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity". Nucleic ...
*  ZNF143
SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of ... Gérard MA, Krol A, Carbon P (2007). "Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene". Gene ... Schuster C, Myslinski E, Krol A, Carbon P (1995). "Staf, a novel zinc finger protein that activates the RNA polymerase III ... Schuster C, Krol A, Carbon P (1998). "Two distinct domains in Staf to selectively activate small nuclear RNA-type and mRNA ...
*  GATA2
Towatari M, Kanei Y, Saito H, Hamaguchi M (1998). "Hematopoietic transcription factor GATA-2 activates transcription from HIV-1 ... a transcription factor. The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have ... Sp1 and GATA factors are necessary for basal transcription in endothelial cells". J. Biol. Chem. 270 (25): 15320-6. doi:10.1074 ... Zhang SB, He QY, Zhao H, Gui CY, Jiang C, Qian RL (2002). "Function of GATA transcription factors in hydroxyurea-induced HEL ...
*  G1 phase
In order for the cell to continue through the G1-pm, there must be a high amount of growth factors and a steady rate of protein ... These complexes then activate S-Cdk complexes that move forward with DNA replication in the S phase. Concurrently, anaphase- ... the way this is phrased it is unclear whether it is transcription of the gene or translation of the mRNA gene product that is ... G1 phase and the other subphases of the cell cycle may be affected by limiting growth factors such as nutrient supply, ...
*  List of MeSH codes (D12.776.930)
... activating transcription factor 1 MeSH D12.776.930.127.061.750 -- activating transcription factor 2 MeSH D12.776.930.127. ... activating transcription factor 4 MeSH D12.776.930.127.061.968 -- activating transcription factor 6 MeSH D12.776.930.127. ... transcription factor brn-3b MeSH D12.776.930.632.625.875 -- transcription factor brn-3c MeSH D12.776.930.635.600.100 -- ets- ... mafg transcription factor MeSH D12.776.930.127.656.750.750 -- mafk transcription factor MeSH D12.776.930.127.656.770 -- nf-e2 ...
ATF3 Activating Transcription Factor 3 | Springer for Research & Development  ATF3 Activating Transcription Factor 3 | Springer for Research & Development
A cellular protein, activating transcription factor, activates transcription of multiple E1a-inducible adenovirus early ... Negative regulation of TLR-signaling pathways by activating transcription factor-3. J Immunol. 2007;179:3622-30.PubMedCrossRef ... Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages. Mol Immunol. 2007;44:1598-605. ... The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its ...
more infohttps://rd.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_612
Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response | Cancer Research  Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response | Cancer Research
Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response. Chunhong Yan, Tsonwin Hai and Douglas Boyd ... Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response Message Subject (Your Name) has forwarded a page ... As a consequence, target genes including p21, PIG3 or PUMA are transcriptionally activated, leading to cell growth arrest or ... ATF3-stabilized p53 was functional as evidenced by its ability to trans-activate p53 downstream targets including MDM2, p21, ...
more infohttp://cancerres.aacrjournals.org/content/65/9_Supplement/862.3
Frontiers | Activating Transcription Factor 3 and the Nervous System | Frontiers in Molecular Neuroscience  Frontiers | Activating Transcription Factor 3 and the Nervous System | Frontiers in Molecular Neuroscience
Of the transcription factors that regulate these changes in gene expression, the function of c-jun is best understood but ATF-3 ... Of the transcription factors that regulate these changes in gene expression, the function of c-jun is best understood but ATF-3 ... That transcription factors must play an important role in enabling neurons to regrow their axons is implicit to the observation ... That transcription factors must play an important role in enabling neurons to regrow their axons is implicit to the observation ...
more infohttps://www.frontiersin.org/articles/10.3389/fnmol.2012.00007/full
THE POTENTIAL DICHOTOMOUS ROLE OF ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) IN COLON CANCER  THE POTENTIAL DICHOTOMOUS ROLE OF ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) IN COLON CANCER
... ... ATF3, a member of the ATF/CREB transcription factor family, plays an important role on regulation of apoptosis and is regarded ... related transcription factors. However, mammosphere forming assay indicated that ATF3 overexpressed colon cancer cells form ...
more infohttps://drum.lib.umd.edu/handle/1903/17382
Contribution of Activating Transcription Factor 3 to development of ac by Jelena Toma  "Contribution of Activating Transcription Factor 3 to development of ac" by Jelena Toma
Our lab has shown that Activating Transcription Factor 3 (ATF3), a factor upregulated during pancreatic injury, contributes to ... The highest risk factor for PDAC is recurrent pancreatitis. While the link between PDAC and pancreatitis is unknown, de- ... Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia ... Our lab has shown that Activating Transcription Factor 3 (ATF3), a factor upregulated during pancreatic injury, contributes to ...
more infohttps://ir.lib.uwo.ca/etd/4719/
Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene...  Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene...
A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early ... Immunoblot assays of activating transcription factor (ATF) 3 immunoprecipitates with tyrosine specific antibodies revealed that ... Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene ... Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene ...
more infohttp://mcr.aacrjournals.org/content/2/7/403
HKU Scholars Hub: Activating transcription factor 3 up-regulated by c-Jun NH 2-terminal kinase/c-Jun contributes to apoptosis...  HKU Scholars Hub: Activating transcription factor 3 up-regulated by c-Jun NH 2-terminal kinase/c-Jun contributes to apoptosis...
Article: Activating transcription factor 3 up-regulated by c-Jun NH 2-terminal kinase/c-Jun contributes to apoptosis induced by ... Activating transcription factor 3 up-regulated by c-Jun NH 2-terminal kinase/c-Jun contributes to apoptosis induced by ... Activating transcription factor 3 up-regulated by c-Jun NH 2-terminal kinase/c-Jun contributes to apoptosis induced by ... Activating transcription factor 3 (ATF3), a stress-inducible protein, belongs to the ATF/CREB family of transcription factors ...
more infohttp://hub.hku.hk/handle/10722/149685
A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription...  A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription...
Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress ... Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in ... Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in ... Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in ...
more infohttp://www.propolisscience.org/propolis-and-cancer/a-taiwanese-propolis-derivative-induces-apoptosis-through-inducing-endoplasmic-reticular-stress-and-activating-transcription-factor-3-in-human-hepatoma-cells/
The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID...  The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID...
... transcription factors can be recruited to multiple complexes, where they function with diverse co-factors to activate or ... can be activated by multiple lineage-specific transcription factors, instead of by a shared factor in multiple lineages. In ... By interacting with conserved COE binding sites, COE family transcription factors activate or repress the expression of target ... This leads to reduced accessibility to transcription factors and to the downregulation of target transcription in neuronal ...
more infohttp://dev.biologists.org/content/142/8/1447
Frontiers | Role of Transcription Factors in Peripheral Nerve Regeneration | Frontiers in Molecular Neuroscience  Frontiers | Role of Transcription Factors in Peripheral Nerve Regeneration | Frontiers in Molecular Neuroscience
Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ...
more infohttps://www.frontiersin.org/articles/10.3389/fnmol.2012.00008/full
The C. elegans COE transcription factor UNC-3 activates lineag...  The C. elegans COE transcription factor UNC-3 activates lineag...
... elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage.: ... The COE (Collier/Olf/EBF) transcription factors have been implicated in the development of many cell types, including neurons. ... The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID ... Unc-3 License. Unknown Abstract. Mechanisms that regulate apoptosis in a temporal and lineage-specific manner remain poorly ...
more infohttps://www.mysciencework.com/publication/show/c-elegans-coe-transcription-factor-unc-3-activates-lineage-specific-apoptosis-affects-neurite-growth-rid-lineage-28417f78
Dr. Tsonwin  Hai - Cancer Researcher at OSUCCC - James  Dr. Tsonwin Hai - Cancer Researcher at OSUCCC - James
Activating transcription factor 3 regulates canonical TGFß signalling in systemic sclerosis.. Mallano T, Palumbo-Zerr K, Zerr P ... Activating transcription factor 3 regulates chemokine expression in contracting C2C12 myotubes and in mouse skeletal muscle ... Activating transcription factor 3 attenuates chemokine and cytokine expression in mouse skeletal muscle after exercise and ...
more infohttps://cancer.osu.edu/research-and-education/find-a-researcher/search-researcher-directory/tsonwin-hai
ATF3 transcription factor and its emerging roles in immunity and cancer.  - PubMed - NCBI  ATF3 transcription factor and its emerging roles in immunity and cancer. - PubMed - NCBI
Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of ... NF-κB and AP-1 are transcription factors, well known for their ability to promote transcription of inflammatory cytokines and ... ATF3 transcription factor and its emerging roles in immunity and cancer.. Thompson MR1, Xu D, Williams BR. ... transcription factors. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19705082
Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? |...  Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? |...
1). ER stress sensors [IRE1 (inositol requiring 1), ATF6 (activated transcription factor 6) and PERK (ER-resident PKR-like eIF2 ... Role for activating transcription factor 3 in stress-induced β-cell apoptosis. Mol Cell Biol 24:5721-5732. doi: 10.1128/mcb. ... The cleaved N-terminal fragment migrates to the nucleus, acts as an active transcription factor, and increases the expression ... Spliced Xbp-1 mRNA encodes a transcription activator that drives transcription of genes such as ER chaperones, whose products ...
more infohttps://link.springer.com/article/10.1007%2Fs10495-009-0400-4
TLR4 Mediates Pneumolysin-Induced ATF3 Expression through the JNK/p38 Pathway in Streptococcus pneumoniae-Infected RAW 264.7...  TLR4 Mediates Pneumolysin-Induced ATF3 Expression through the JNK/p38 Pathway in Streptococcus pneumoniae-Infected RAW 264.7...
Furthermore, ATF3 induction is mediated by p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK). Thus ... The expression of ATF3 was induced by pneumolysin (PLY), a potent pneumococcal virulence factor, via the TLR4 pathway. ... A recent study reported that ATF3 provides protection from Streptococcus pneumoniae infection by activating cytokines. However ... Activating transcription factor-3 (ATF3) acts as a negative regulator of cytokine production during Gram-negative bacterial ...
more infohttps://www.semanticscholar.org/paper/TLR4-Mediates-Pneumolysin-Induced-ATF3-Expression-Nguyen-Kim/f516d43bcce54b8f1326ac6ee88d681fff4536a3
GO Gene List  GO Gene List
Activating transcription factor 6. NM_007348. Gene Info. ATP6V0A1. ATPase, H+ transporting, lysosomal V0 subunit a1. NM_ ... Activating transcription factor 3. NM_001040619. NM_001674. NM_001206488. NM_001206484. NM_001206486. NM_001030287. Gene Info. ... Activating transcription factor 4 (tax-responsive enhancer element B67). NM_001675. NM_182810. Gene Info. ... ADP-ribosylation factor GTPase activating protein 1. NM_175609. NM_018209. Gene Info. ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0070887
Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network...  Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network...
... and 3) observe the complex interplay between genes/gene products that function in seemingly different processes. This study ... Activating transcription factor 3. 19.5. GEM GTP binding protein overexpressed in skeletal muscle ... EPAS1 (endothelial PAS domain protein-1, or HIF2α) is one of the transcription factors which belong to the basic helix-loop- ... Shukla A, Ramos-Nino M, Mossman B: Cell signaling and transcription factor activation by asbestos in lung injury and disease. ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-9-376
Dysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets | BMC Genomics | Full Text  Dysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets | BMC Genomics | Full Text
ALB: albumin; ATF3: activating transcription factor 3; IL6ST: interleukin-6 receptor subunit beta; PDK4: pyruvate dehydrogenase ... activating transcription factor 3 (ATF3), interleukin-6 receptor subunit beta (IL6ST), pyruvate dehydrogenase kinase, isozyme 4 ... Satellite/centr may change expression of nearby genes via changing the binding of the transcription factors to chromatin [53]. ... Lee JH, Campbell KH: Effects of enucleation and caffeine on maturation-promoting factor (MPF) and mitogen-activated protein ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-811
Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional...  Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional...
Expression of ATF3 (activating transcription factor 3) is induced by a variety of environmental stress conditions, including ... activating transcription factor; bZIP, basic region/leucine zipper; C/EBP, CCAAT/enhancer-binding protein; ChIP, chromatin ... A comparison of the recruitment patterns between ATF and C/EBP transcription factors and RNA polymerase II at the AARE of ... through a highly co-ordinated amino acid-responsive programme of transcription factor synthesis and action. Studies using ...
more infohttp://www.biochemj.org/content/401/1/299
Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark | BMC Complementary and Alternative Medicine |...  Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark | BMC Complementary and Alternative Medicine |...
MRBE treatment to SW480 cells activated ATF3 expression and down-regulated cyclin D1 level. We also observed that MRBE-induced ... Activating transcription factor 3 (ATF3) is a member of the ATF/CREB subfamily of the basic-region leucine zipper (bZIP) family ... Wang H, Mo P, Ren S, Yan C: Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to ... Yan C, Lu D, Hai T, Boyd DD: Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. ...
more infohttps://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-200
  • Pancreatitis is a debilitating disease of the exocrine pancreas that, under chronic conditions, is a major susceptibility factor for pancreatic ductal adenocarcinoma (PDAC). (rare-cancer.org)
  • the caspase activator CED-4 ( Yuan and Horvitz, 1992 ) and the pro-caspase CED-3 ( Ellis and Horvitz, 1986 ). (biologists.org)
  • Several main apoptotic indicators were found in GS-002-treated cells, such as the cleaved forms of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP). (propolisscience.org)
  • We observed that ATF4 is activated and translocates to the nucleus following lipopolysaccharide (LPS) stimulation via the TLR4-MyD88-dependent pathway. (biomedsearch.com)
  • Isoform 3 does not promote the chemotactic activity of leukocyte cells. (genecards.org)
  • The effects of inhibiting neutrophil elastase during the early inflammatory phase of MIA (days 0 to 3) were determined using sivelestat (50 mg/kg i.p.) and serpinA1 (10 μg i.p. (biomedcentral.com)
  • Lastly, UNC-3 interacts with CBP-1, and cbp-1 mutants exhibit a similar RID phenotype to unc-3 . (biologists.org)
  • The known substrates of MMPs include basement membrane and matrix components such as collagens, fibronectin, vitronectin, laminin, and tenascin ( 2 , 3 ). (aacrjournals.org)
  • The highest risk factor for PDAC is recurrent pancreatitis. (uwo.ca)
  • Some neurotrophic factors such as brain-derived neurotrophic factor, 15 , 18 , 19 ciliary neurotrophic factor, 19 - 21 and glial cell-derived neurotrophic factor 22 , 23 are found to be effective for promoting RGC survival and axonal regeneration against ONC. (arvojournals.org)