Activated-Leukocyte Cell Adhesion Molecule
Cell Adhesion Molecules, Neuronal
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).
Cell Adhesion Molecules
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Neural Cell Adhesion Molecules
Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
Vascular Cell Adhesion Molecule-1
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
Neural Cell Adhesion Molecule L1
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Intercellular Adhesion Molecule-1
Distribution and function of the adhesion molecule BEN during rat development. (1/109)It is well established that the notochord influences the development of adjacent neural and mesodermal tissue. Involvement of the notochord in the differentiation of the dorsal pancreas has been demonstrated. However, our knowledge of the signals involved in pancreatic development is still incomplete. In order to identify proteins potentially implicated during pancreatic differentiation, we raised and characterized monoclonal antibodies against previously established embryonic pancreatic ductal epithelial cell lines (BUD and RED). Using the MAb 2117, the cell surface antigen 2117 (Ag 2117) was cloned. The predicted sequence for Ag 2117 is the rat homologue of BEN. Initially reported as a protein expressed on epithelial cells of the chicken bursa of Fabricius, BEN is expressed in a variety of tissues during development and described as a marker for the developing central and peripheral chicken nervous systems. A role has been suggested for BEN in the adhesion of stem cells and progenitor cells to the blood-forming tissue microenvironment. In this study, we demonstrate that BEN, initially expressed exclusively in the notochord during the early development of rat, is implicated in pancreatic development. We show that Ag 2117 regulates the pancreatic epithelial cell growth through the ras and Jun kinase pathways. In addition, we demonstrate that Ag 2117 is able to regulate the expression of the transcription factor PDX1, required for insulin gene expression, in embryonic pancreas organ cultures. (+info)
Extracellular matrix-associated protein Sc1 is not essential for mouse development. (2/109)Sc1 is an extracellular matrix-associated protein whose function is unknown. During early embryonic development, Sc1 is widely expressed, and from embryonic day 12 (E12), Sc1 is expressed primarily in the developing nervous system. This switch in Sc1 expression at E12 suggests an importance for nervous-system development. To gain insight into Sc1 function, we used gene targeting to inactivate mouse Sc1. The Sc1-null mice showed no obvious deficits in any organs. These mice were born at the expected ratios, were fertile, and had no obvious histological abnormalities, and their long-term survival did not differ from littermate controls. Therefore, the function of Sc1 during development is not critical or, in its absence, is subserved by another protein. (+info)
Evidence for the expression of a second CD6 ligand by synovial fibroblasts. (3/109)OBJECTIVE: CD6, a cell surface glycoprotein expressed primarily on T cells, may function as a costimulatory molecule and may play a role in autoreactive immune responses. Recently, a CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule [ALCAM]) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. However, the results of functional studies have suggested the existence of a second CD6 ligand. The present study was undertaken to seek evidence for a second CD6 ligand on cultured synovial fibroblasts. METHODS: Flow cytometric and biochemical techniques were applied, using anti-CD166 monoclonal antibody (mAb) and a recombinant CD6 fusion protein, to determine whether cultured synovial fibroblasts and other cell types expressed a non-ALCAM CD6 ligand. RESULTS: CD14- fibroblastic synoviocytes showed greater binding of a recombinant CD6 fusion protein than of anti-ALCAM mAb. With interferon-gamma treatment of synovial fibroblasts, binding of both reagents increased, but this was more marked for binding of CD6 fusion protein. Exposure of synovial fibroblasts to other cytokines or to the superantigen staphylococcal enterotoxin A also regulated binding of CD6 fusion protein and anti-ALCAM mAb in a discordant manner. Immunoprecipitation of proteins from membrane extracts of synovial fibroblasts with a CD6-Ig fusion protein revealed a novel 130-kd band distinct from CD166; an identical molecule was also precipitated from membranes of HBL-100 tumor cells. CONCLUSION: Taken together with previous data regarding CD6 and CD166 function, the present findings strongly suggest the existence of a second CD6 ligand distinct from CD166, which can be expressed by synovial fibroblasts as well as other cells. (+info)
Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin. (4/109)Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions reveals that ALCAM expression correlates with melanoma progression. Most nevi (34/38) and all thin melanomas studied (Clark levels I and II) did not express ALCAM. In contrast, immunoreactivity was detected in the invasive, vertical growth phase of 2 of the 13 Clark level III lesions tested. The fraction of positive lesions further increased in Clark level IV (13/19) and in Clark level V (4/4) lesions. ALCAM expression was exclusively detectable in the vertical growth phase of the primary tumor. In melanoma metastases, approximately half of the lesions tested (13/28) were ALCAM positive. According to the Breslow-thickness, ALCAM expression was observed in less than 10% of the lesions that were thinner than 1.5 mm and in over 70% of the lesions that were thicker than 1.5 mm. Our results strongly suggest that ALCAM plays an important role in melanocytic tumor progression and depict it as a new molecular marker for neoplastic progression of primary human melanoma. (+info)
DM-GRASP is necessary for nonradial cell migration during chick diencephalic development. (5/109)Cell migration is fundamental to normal CNS development. Radial migration, along radial glial fibers, has been the principal pathway studied, however, nonradial or tangential cell migration has increasingly been identified at all levels of the CNS. Receptors, cell adhesion molecules, and extracellular matrix molecules have all been shown to participate in radial cell migration. In contrast, the molecular basis of nonradial cell migration has only recently begun to be elucidated. Using replication defective retroviral vectors we have determined the location and time when nonradial cell migration begins in the developing chick diencephalon. We have identified three molecules that are expressed in spatially and temporally restricted domains that are consistent with them playing a role in nonradial cell migration. One of these molecules, DM-GRASP, a transmembrane protein with five extracellular Ig domains, is expressed on the nonradially migrating cells in addition to axons. To test the hypothesis that DM-GRASP participates in guiding nonradial cell migration, we injected a replication-defective retroviral vector used for lineage tracing followed by a DM-GRASP blocking antibody. Embryos injected with the blocking antibody showed a near complete block in nonradial cell migration specifically where DM-GRASP is expressed. Furthermore, morphological analyses revealed disruption of the normal architecture of the diencephalon indicating nonradial cell migration is necessary for normal morphological development of the brain. Our data indicate that DM-GRASP is necessary for nonradial cell migration in the chick diencephalon and have provided a system to further explore the function of nonradial cell migration during CNS development. (+info)
Dynamic regulation of activated leukocyte cell adhesion molecule-mediated homotypic cell adhesion through the actin cytoskeleton. (6/109)Restricted expression of activated leukocyte cell adhesion molecule (ALCAM) by hematopoietic cells suggests an important role in the immune system and hematopoiesis. To get insight into the mechanisms that control ALCAM-mediated adhesion we have investigated homotypic ALCAM-ALCAM interactions. Here, we demonstrate that the cytoskeleton regulates ALCAM-mediated cell adhesion because inhibition of actin polymerization by cytochalasin D (CytD) strongly induces homotypic ALCAM-ALCAM interactions. This induction of cell adhesion is likely due to clustering of ALCAM at the cell surface, which is observed after CytD treatment. Single-particle tracking demonstrated that the lateral mobility of ALCAM in the cell membrane is increased 30-fold after CytD treatment. In contrast, both surface distribution and adhesion of a glycosylphosphatidylinositol (GPI)-anchored ALCAM mutant are insensitive to CytD, despite the increase in lateral mobility of GPI-ALCAM upon CytD treatment. This demonstrates that clustering of ALCAM is essential for cell adhesion, whereas enhanced diffusion of ALCAM alone is not sufficient for cluster formation. In addition, upon ligand binding, both free diffusion and the freely dragged distance of wild-type ALCAM, but not of GPI-ALCAM, are reduced over time, suggesting strengthening of the cytoskeleton linkage. From these findings we conclude that activation of ALCAM-mediated adhesion is dynamically regulated through actin cytoskeleton-dependent clustering. (+info)
Expression of DM-GRASP/BEN in the developing mouse spinal cord and various epithelia. (7/109)The expression pattern of the immunoglobulin DM-GRASP/BEN gene was studied in the mouse embryo using in situ hybridization. DM-GRASP/BEN is expressed in the spinal cord in a subset of motoneurons expressing Islet-1, and non homogeneously in the dorsal root ganglia (DRG). In contrast, it's expression is homogeneous in the vestibulo-cochlear and trigemminal ganglia. DM-GRASP/BEN is also expressed in various epithelia of ectodermal or endodermal origin like the nasal, buccopharyngal and lung epithelia. In upper lip, DM-GRASP/BEN transcripts are present in the epidermal cells of the developing hair vibrissa follicles. First detected in the hair placode, DM-GRASP/BEN expression is localized in the central cells of the epithelial hair peg and then in a thin layer of cells crushed against the outer root sheath by the outgrowth of the hair shaft. (+info)
A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells. (8/109)In lower vertebrates, retinal ganglion cells (RGCs) can regenerate their axons and reestablish functional connections after optic nerve injury. We show here that in goldfish RGCs, the effects of several trophic factors converge on a purine-sensitive signaling mechanism that controls axonal outgrowth and the expression of multiple growth-associated proteins. In culture, goldfish RGCs regenerate their axons in response to two molecules secreted by optic nerve glia, axogenesis factor-1 (AF-1) and AF-2, along with ciliary neurotrophic factor. The purine analog 6-thioguanine (6-TG) blocked outgrowth induced by each of these factors. Previous studies in PC12 cells have shown that the effects of 6-TG on neurite outgrowth may be mediated via inhibition of a 47 kDa protein kinase. Growth factor-induced axogenesis in RGCs was accompanied by many of the molecular changes that characterize regenerative growth in vivo, e.g. , increased expression of GAP-43 and certain cell surface glycoproteins. 6-TG inhibited all of these changes but not those associated with axotomy per se, e.g., induction of jun family transcription factors, nor did it affect cell survival. Additional studies using RGCs from transgenic zebrafish showed that expression of Talpha-1 tubulin is likewise stimulated by AF-1 and blocked by 6-TG. The purine nucleoside inosine had effects opposite to those of 6-TG. Inosine stimulated outgrowth and the characteristic pattern of molecular changes in RGCs and competitively reversed the inhibitory effects of 6-TG. We conclude that axon regeneration and the underlying program of gene expression in goldfish RGCs are mediated via a common, purine-sensitive pathway. (+info)
Lentigo: a benign growth or spot on the skin that is usually flat and tan, brown, or black, and often appears as a single patch or multiple patches on sun-exposed areas of the face, hands, or arms. It may be caused by exposure to the sun or other forms of radiation, and is more common in fair-skinned individuals.
Also known as: solar lentigo, senile lentigo, and lentigo simplex.
... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... 2003). "Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166)". J ... "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule". Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, ...
... and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213-20. doi: ... domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of ... "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule ... "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells". J. Biol. Chem. 278 (10): 8564-71. doi: ...
A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2. Mutations in the MMP2 gene ... allowing them to bind with cell receptors and influence cell signaling. Furthermore, many MMPs also activate other proMMPs ... Massagué J (July 2008). "TGFbeta in Cancer". Cell. 134 (2): 215-30. doi:10.1016/j.cell.2008.07.001. PMC 3512574. PMID 18662538 ... "Human endometrial epithelial cells modulate the activation of gelatinase a by stromal cells". Gynecol. Obstet. Invest. 53 (2): ...
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by ... These bioactive molecules play roles in coagulation, complement activation, DNA replication, cell-cycle control, cellular ... Placing a reactive group and a recognizable tag feature on the same molecule using a linker moiety gives an ABP molecule its ... Cell Proteomics 3(6):565-76 (2004). Bredemeyer A.J., Lewis R.M., Malone J.P., Davis A.E., Gross J., Townsend R.R., Ley T.J. A ...
Pathophysiology of multiple sclerosis
... one of these adhesion proteins involved is ALCAM (Activated Leukocyte Cell Adhesion Molecule, also called CD166), and is under ... Apart from that, activated T-Cells can cross a healthy BBB when they express adhesion proteins. (Adhesion molecules could also ... because activated T-Cells can cross a healthy BBB when they express adhesion proteins. ... produced by CD8+ T-cells or CD20+ B-cells), creates a toxic environment that activates microglia. MRI-abnormal areas with ...
... or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial ... "E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro". Immunology. 77 (4 ... In endothelial cells, various cell-adhesion molecules including E-selectin, are shown to be upregulated upon exposure to ... E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), ...
List of MeSH codes (D12.776.395)
... cell adhesion molecules, neuron-glia MeSH D12.776.395.5188.8.131.52.050 - activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.395.5184.108.40.2060.156 - antigens, cd56 MeSH D12.776.395.5220.127.116.110.578 - ... vascular cell adhesion molecule-1 MeSH D12.776.395.550.550.500 - lysosomal-associated membrane protein 1 MeSH D12.776.395.550. ... neural cell adhesion molecule l1 MeSH D12.776.395.550.200.275 - integrin alphaxbeta2 MeSH D12.776.395.550.200.450 - ...
List of MeSH codes (D23)
... cell adhesion molecules, neuron-glia MeSH D23.050.301.350.250.150.050 - activated-leukocyte cell adhesion molecule MeSH D23.050 ... activated-leukocyte cell adhesion molecule MeSH D18.104.22.168.101 - antigens, cd1 MeSH D22.214.171.124.102 - antigens, cd2 ... activated-leukocyte cell adhesion molecule MeSH D23.050.301.264.035.101 - antigens, cd1 MeSH D23.050.301.264.035.102 - antigens ... neural cell adhesion molecules MeSH D23.050.301.350.250.520.156 - antigens, cd56 MeSH D23.050.301.350.250.520.578 - neural cell ...
List of MeSH codes (D12.776.543)
... cell adhesion molecules, neuron-glia MeSH D12.776.543.5126.96.36.199.050 - activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.543.5188.8.131.520.156 - antigens, cd56 MeSH D12.776.543.5184.108.40.2060.578 - ... vascular cell adhesion molecule-1 MeSH D12.776.543.550.425.150 - calcium channels MeSH D12.776.543.550.425.150.400 - calcium ... neural cell adhesion molecule l1 MeSH D12.776.543.550.200.275 - integrin alphaxbeta2 MeSH D12.776.543.550.200.450 - ...
... genes that encode endothelial cell adhesion molecules, causing decreased lymphocyte and leukocyte activation and hence ... T-cells are activated and more prone to apoptosis without KLF2, suggesting that KLF2 regulates T-cell quiescence and survival. ... This activates mechanosensitive channels, which in turn activates two pathways; the MEK5/ERK5 pathway, which activates MEF2, a ... but it is also expressed temporally during embryogenesis in erythroid cells, endothelium, lymphoid cells, the spleen, and white ...
... adhesion molecules, and other inflammatory mediators. They also reduce synthesis of histamine, stabilize cell membranes, and ... After it binds to the GR in the cytoplasm, the activated corticosteroid-GR complex migrates to the nucleus, where it ... and migration of leukocytes. Neither loteprednol etabonate nor its inactive metabolites Δ1-cortienic acid and Δ1-cortienic acid ... inhibit degranulation of mast cells. Recent work suggests that the activated corticosteroid-GR complex also elicits nongenomic ...
... cells SGEF was recruited to the intracellular domain of the transmembrane adhesion molecule ICAM-1 upon leukocyte adhesion to ... that function to activate small G proteins. In their resting state G proteins are bound to guanosine diphosphate (GDP) and ... SGEF is also expressed in endothelial cells of the vasculature. Several widely used cell lines express this protein, these ... Cell. 15 (7): 3309-19. doi:10.1091/mbc.E04-02-0146. PMC 452585. PMID 15133129. Samson et al 2013 "The Guanine-Nucleotide ...
APC affects endothelial cells by inhibiting inflammatory mediator release and down-regulating vascular adhesion molecules. This ... Activated leukocytes release these inflammatory mediators during inflammation, inhibiting the creation of both thrombomodulin ... and it is these cells and leukocytes (white blood cells) that APC affects.: 34 : 3162 Because of the crucial role that protein ... The activated form plays an important role in regulating anticoagulation, inflammation, and cell death and maintaining the ...
2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes ... Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. ... Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c ( ... "Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)". Oikawa S ...
... intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells ... ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells ... Frijns CJ, Kappelle LJ (Aug 2002). "Inflammatory cell adhesion molecules in ischemic cerebrovascular disease". Stroke: A ... With the roles of ICAM-1 in cell-cell adhesion, extravasation, and infection more fully understood, a potential role for ICAM-1 ...
... vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1(ICAM-1), and E-selectin). PARs contribute to the ... For example PAR4 induces leukocyte migration and PAR2 helps macrophages to produce cytokines such as interleukin-8 (IL-8). ... Protease-activated receptor 1 Protease-activated receptor 2 Protease-activated receptor 3 Macfarlane SR, Seatter MJ, Kanke T, ... They are highly expressed in platelets, and also on endothelial cells, myocytes and neurons. Protease-activated receptors PAR ...
Concomitantly they induce local expression of adhesive molecules. Together they increase leukocytes adhesion and extravasation ... Kinin increase vascular permeability by acting on vascular endothelial cells to cause cell contraction. ... Kallikreins activate kinins when stimulated. It is a component of the kinin-kallikrein system. Their precursors are kininogens ... cell differentiation and plant development". Bioactive Natural Products (Part N). Studies in Natural Products Chemistry. Vol. ...
... and changes in the avidity of cell adhesion molecules called integrins. Chemokines and their receptors play a crucial role in ... The subunit called Gα activates an enzyme known as Phospholipase C (PLC) that is associated with the cell membrane. PLC cleaves ... This role of chemokine is strikingly similar to their normal function of localizing leukocytes to an inflammatory site. Human ... This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location ...
... binding to the intercellular adhesion molecule-1 (ICAM-1). CR3 causes phagocytosis and destruction of cells opsonized with iC3b ... A fully activated neutrophil may express on its membrane 200,000 or more CR3 molecules. Absence of CR3 results in reduced ... polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages. CR3 is a pattern ... phagocytosis and other cell-cell interactions in a variety of cells and circumstances. Upregulation of Mac-1 in the presence of ...
High endothelial venules
Naïve T cells express CCR7 receptor and adhesion molecules L-selectin and LFA-1. As naïve T cells move through the circulation ... In order to have an adaptive immune response to occur T cells need to be activated. T cells become activated by recognising ... consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for ... HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor ...
... and leukocytes: The inflamed blood vessels specifically express certain receptors, functioning as cell adhesion molecules, like ... Thrombosis and thrombolysis: Activated platelets are major components of blood clots (thrombi). Microbubbles can be conjugated ... Leukocytes possess high adhesion efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system. One ligand: ... and biomimicry of the leukocyte's selectin-integrin cell arrest system, having shown an increased adhesion efficiency, but yet ...
Selectins are adhesion molecules that facilitate the capture of circulating leukocytes. Sulfatide is also expressed on the ... Type 2 Natural killer T cells are able to recognize sulfatide/ CD1d tetramers, and as a result, they are activated by different ... Macrophages Dendritic cells Hepatocytes B cells Tumour cells Thymocytes Each of these different cell types are expressed in ... There are two types of cell subtypes that interact with CD1d cells: Type 1 Natural killer T cells and Type 2 Natural killer T ...
... cells as well as inducing the production of costimulatory molecules that allow the cell to bind to and activate T cells more ... leading to increased expression of adhesion molecules that recruit leukocytes to infected regions. This causes inflammation in ... and can activate up to 100% of T cells). The large number of activated T-cells generates a massive immune response which is not ... of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells. Furthermore, Anti- ...
β2 integrins on rolling leukocytes bind endothelial cellular adhesion molecules, arresting cell movement. LFA-1 is found on ... Activated endothelial cells initially express P-selectin molecules, but within two hours after activation E-selectin expression ... Leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis - the passage of cells through the ... white blood cells). The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to ...
... and their presentation to specific cell-surface receptors. The binding of versican with leukocyte adhesion molecules L-selectin ... "Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis". Nature. 457 (7225): 102-6. Bibcode: ... large family of cell adhesion molecules) with their cell surface receptors is sterically hindered. Expression of versican is ... Different tenascin domains interact with a wide range of cellular receptors, including integrins, cell adhesion molecules and ...
Complement component 5a
White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. ... C5a is an anaphylatoxin, causing increased expression of adhesion molecules on endothelium, contraction of smooth muscle, and ... C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the ... Both C5a and C5a des-Arg can trigger mast cell degranulation, releasing proinflammatory molecules histamine and TNF-α. C5a is ...
It has also been demonstrated that resistin upregulates intercellular adhesion molecule-1 (ICAM1) vascular cell-adhesion ... Inflammation is the first innate immune response to infection or irritation resulting from leukocyte (neutrophils, mast cells, ... nuclear factor kappa-light-chain-enhancer of activated B cells-mediated) fashion. ... In primates, pigs, and dogs, resistin is secreted by immune and epithelial cells, while, in rodents, it is secreted by adipose ...
P-selectin glycoprotein ligand-1
... leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the ... As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. ... of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell ... However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood ...
The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are ... The rolling cancer cells then become activated by locally released chemokines present at the surface of endothelial cells. This ... action attributed to leukocytes during the leukocyte adhesion cascade. Each selectin has a carbohydrate recognition domain that ... On the other hand, several studies further show that cancer cells may initiate the expression of endothelial adhesion molecules ...
Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help". Journal of Immunology. 149 (12): ... and expression of adhesion molecules such as E-selectin, ICAM-1, and VCAM-1. This inflammatory reaction in endothelial cells ... van Kooten C, Banchereau J (January 2000). "CD40-CD40 ligand". Journal of Leukocyte Biology. 67 (1): 2-17. doi:10.1002/jlb.67.1 ... If an activated TFH cell recognizes the peptide presented by the B cell, the CD40L on the T cell binds to the B cell's CD40, ...
... is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node ... Leucocyte Typing III:White Cell Differentiation Antigens.Oxford University Press 630-635. Sidney LE, Branch MJ, Dunphy SE, Dua ... "Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells". The Journal of Biological ... as a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of ...
... cell-cycle regulation, angiogenesis, and cell adhesion. The correlative studies analyzing the expression of galectin-9 and ... "Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells". Journal of Leukocyte Biology. 72 ... January 2020). "AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed ... "Upregulation of Galectin-9 and PD-L1 Immune Checkpoints Molecules in Patients with Chronic Lymphocytic Leukemia". Asian Pacific ...
... adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also plays a ... The proteolytic capacity of 20S core particle (CP) can be activated when CP associates with one or two regulatory particles (RP ... UPS proteolysis plays a major role in responses of cancer cells to stimulatory signals that are critical for the development of ... role in inflammatory responses as regulators of leukocyte proliferation, mainly through proteolysis of cyclines and the ...
... Cells destined for apoptosis release molecules referred to as find me signals. These signal molecules are used ... A soluble fragment of fractalkine that is usually on the plasma membrane as a intercellular adhesion molecule is sent out as a ... This molecule has inflammatory properties, meaning it is capable of attracting and activating neutrophils. Humans turn over ... Journal of Leukocyte Biology. 79 (5): 896-903. doi:10.1189/jlb.1005550. Ravichandran, Kodi S.; Lorenz, Ulrike (December 2007 ...
CD24 is associated with B-cells, epithelial cells, and dendritic cells, functioning as an adhesion molecule and shown to ... Additionally, it acts as an adhesion molecule for leukocytes on peripheral lymphoid organs and inflammation sites. ... and on the positive strand is the gene Mitogen-activated protein kinase, kinase 3 (MAP2K3). Microarray and EST data indicates ... Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. Sowa ...
Leukocytes also exhibit L-selectin that binds to other cells or other leukocytes that contain PSGL-1 molecules. An important ... "Catch-Bond Model Derived from Allostery Explains Force-Activated Bacterial Adhesion". Biophysical Journal. 90 (3): 753-764. ... integrin alpha L beta 2 and intercellular adhesion molecule 1 (ICAM-1), integrin alpha 4 beta 1 with vascular adhesion molecule ... Leukocytes, as well as other types of white blood cells, normally form weak and short-lived bonds with other cells via selectin ...
... as well as adhesion and chemoattractant molecules, which recruit aid in recruitment of mononuclear immune cells. Both genetic ... In support of T cell involvement, certain human leukocyte antigen (HLA) variants are strongly associated with PSC risk. Further ... An important regulator in bile acid homeostasis is the alpha and delta isoforms of the peroxisome proliferator-activated ... cholangiocytes and hepatocytes display aberrant expression of adhesion molecules, which facilitate homing of intestinal T cells ...
Many cell types are capable of migration, such as leukocytes and fibroblasts, and in order for these cells to move in one ... Many of the molecules responsible for regulating cell polarity are conserved across cell types and throughout metazoan species ... At the rear of the cell, adhesions are disassembled and bundles of actin microfilaments, called stress fibers, contract and ... and by its GTPase-activating proteins (GAPs). Cdc42 localization is further regulated by cell cycle queues, and a number of ...
White blood cell
... chronic idiopathic neutrophilia Pelger-Huët anomaly Down syndrome Leukocyte adhesion deficiency Familial cold urticaria ... T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors and CD4 molecules that, in ... activate the complement system, and enhance pathogen destruction. T cells: CD4+ helper T cells: ... Lymphoid cells (lymphocytes) include T cells (subdivided into helper T cells, memory T cells, cytotoxic T cells), B cells ( ...
... sometimes called T helper cells). These T cells bind to the MHC II-antigen molecule and cause activation of the B cell. This is ... the activated B cell begins to differentiate into more specialized cells. Germinal center B cells may differentiate into memory ... Leukocyte Plasma cell dyscrasia Guyton and Hall Textbook of Medical Physiology 14th edition: unit 6, chapter 35. "Plasma Cell ... August 2003). "Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals". Journal of ...
... functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner ... February 1999). "Leukocyte-endothelial cell adhesion: avenues for therapeutic intervention". Br J Pharmacol. 126 (3): 537-550 [ ... white blood cells) to the site of injury during inflammation. When endothelial cells are activated by molecules such as ... and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors". J. Cell Biol. 142 (5): 1381-91. doi: ...
... proteins released from certain cells, which activate or elicit a response from other cells) accumulate at any location in the ... Macrolides also reduce the efficiency of adhesion molecules that allow neutrophils to stick to bronchiolar tissue linings. ... Inflammation is a normal part of the human immune response, whereby leukocytes (white blood cells), including neutrophils ( ... The infected cells then become targets for types of cytotoxic T-cells, which kill the infected cells so they can be removed ...
"Mechanisms underlying acute mast cell-induced leukocyte rolling and adhesion in vivo". Journal of Immunology. 154 (2): 804-813 ... γδ T cells possess characteristics of both the innate and adaptive immune responses. Macrophages can also activate T cells in a ... on or within accessory cells. The ability of the immune system to recognize molecules that are broadly shared by pathogens is, ... that are expressed on the membranes of leukocytes including dendritic cells, macrophages, natural killer cells, cells of the ...
... a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using ... membrane-bound proteoglycan into a paracrine effector molecule with roles in wound repair and invasive growth of cancer cells. ... April 2002). "Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature". Investigative Ophthalmology ... It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood. For plasma ...
... adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also plays a ... Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. ... The proteolytic capacity of 20S core particle (CP) can be activated when CP associates with one or two regulatory particles (RP ... role in inflammatory responses as regulators of leukocyte proliferation, mainly through proteolysis of cyclines and the ...
Splenic macrophages and adhesion molecules may be involved in regulation of extramedullary myeloid cell generation in ... Red and white blood cell production is regulated with great precision in healthy humans, and the production of leukocytes is ... inhibits the induction of the T helper type 1 programme in activated CD4 T cells". Immunology. 147 (4): 476-487. doi:10.1111/ ... The lymphoid lineage is composed of T-cells, B-cells and natural killer cells. This is lymphopoiesis. Cells of the myeloid ...
Cell surface receptors allow neutrophils to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon ... In addition to recruiting and activating other cells of the immune system, neutrophils play a key role in the front-line ... Glitter cells are polymorphonuclear leukocyte neutrophils with granules. In 2004, Brinkmann and colleagues described a striking ... ISBN 978-0-521-88729-8. Pantarelli C, Welch HC (November 2018). "Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and ...
The diminished amounts of IL-2 also cause fewer T lymphocyte cells to be activated. The effect of glucocorticoids on Fc ... secretory leukocyte protease inhibitor 1 (SLPI), and Mitogen-activated protein kinase phosphatase (MAPK phosphatase) Increased ... a key proinflammatory molecule. This is one mechanism by which glucocorticoids have an anti-inflammatory effect. A variety of ... adhesion proteins) that promote the immune response. Inhibition of this transcription factor, therefore, blunts the capacity of ...
These molecules activate both CD8+ T cells as well as natural killer cells and attract them to the tumor. It has been shown ... cancer cell expression of intercellular adhesion molecule-1 and enhances natural killer cell sensitivity on cancer cells". ... "Distribution of VIM-2 and SSEA-1 glycoconjugate epitopes among human leukocytes and leukemia cells". Leukemia Research. 14 (2 ... These molecules activate both CD8+ T cells as well as natural killer cells. UV-inactivated SeV triggers the production of an ...
... adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also plays a ... "Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells". Journal of ... The proteolytic capacity of 20S core particle (CP) can be activated when CP associates with one or two regulatory particles (RP ... of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules ...
Natural killer cell
... even in the absence of surface adhesion molecules and antigenic peptides. This role of NK cells is critical to immune success ... These uNK cells are the most abundant leukocytes present in utero in early pregnancy, representing about 70% of leukocytes here ... Natural killer cells directly kill senescent cells, and produce cytokines which activate macrophages which remove senescent ... NK cells are thought to be an important cell type in this process. These cells are known as "uterine NK cells" (uNK cells) and ...
In NK cells, ligands for inhibitory receptors are often MHC class I (MHC-I) molecules, while those for activating receptors may ... Expression of paired receptors is common in many types of leukocytes, especially myeloid cells and natural killer (NK) cells. ... "Coevolution of paired receptors in Xenopus carcinoembryonic antigen-related cell adhesion molecule families suggests ... In some cases, only one member of the pair is expressed in a cell type. Expression of the paired members in a single cell type ...
... altering leukocyte adhesion and proliferation, inducing apoptosis (cell death) of the lymphocytes, possibly with a toxic effect ... An uncontrolled immune response is then activated because leukocytes are not recruited to the specific site of infection, but ... Blood Cells, Molecules & Diseases. 24 (3): 340-355. doi:10.1006/bcmd.1998.0201. PMID 10087992. Poltorak A, He X, Smirnova I, ... Neutrophils, monocytes, macrophages, dendritic cells, CD4+ T cells, and B cells all undergo apoptosis, whereas regulatory T ...
Eugene C. Butcher
He and his research team have shown that lymphocytes use a variety of different adhesion molecules or "homing receptors" to ... Butcher and his research team study the trafficking of white blood cells (lymphocytes, dendritic cells, monocytes, etc.), ... These events regulate immune responses by controlling the access of leukocytes to sites of inflammatory or immune reaction in ... "Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction." J Clin ...
In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still ... Role in T cell homotypic adhesion". J. Immunol. 157 (12): 5262-8. PMID 8955171. Furuyama T, Inagaki S, Kosugi A, et al. (1997 ... 1996). "Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation". Proc. Natl. Acad. Sci ... Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in ...
Proteases in angiogenesis
For example, leukocytes complex urokinase (uPA), urokinase receptor (uPAR), and integrins which participate in cell adhesion ... Activated c-kit is then able to recruit hematopoietic, endothelial and mast cell progenitor cells, these cells are then ... This ability was shown for VEGF165 that is cleaved by MMP-3 or MMP-9 to a smaller molecule with properties similar to VEGF121. ... This is facilitated by a balanced interplay between detachment and formation of cell adhesions which enable the cell to crawl ...
... endothelial cells become activated, which is characterized by the expression of molecules such as E-selectin, VCAM-1 and ICAM-1 ... which stimulate the adhesion of immune cells. Additionally, transcription factors, which are substances which act to increase ... Vestweber D (November 2015). "How leukocytes cross the vascular endothelium". Nature Reviews. Immunology. 15 (11): 692-704. doi ... activated endothelial cells release proteases leading to the degradation of the basement membrane endothelial cells are freed ...
... adhesion of leukocytes to endothelial cells is related with morphological changes in both leukocytes and endothelial cells, ... Through binding to the RANK receptor it activates various molecules, like NF-kappa B, MAPK, NFAT and PI3K52. The RANKL/RANK ... These receptors, that recognize the antigen soluble (B cells) or linked to a molecule on Antigen Presenting Cells (T cells), do ... Mitogen stimulation mobilizes these cells into cycle by activating cyclin D expression. In old adult stem cells, let-7 microRNA ...
Activated leukocyte cell adhesion molecule: a novel biomarker for breast cancer.
MeSH Coming Attractions. NLM Technical Bulletin. Sep-Oct 1998
Activated-Leukocyte Cell Adhesion Molecule*. Algal Proteins. proteins found in any species of algae. ... Short form: RECEPT IL 7; receptors present on T cells and B cell precursors but not mature B cells. ... Short form: PHOTORECEPT MICROBIAL; light absorbing molecules that can initiate a specific photochemical reaction. ...
DeCS - Termos Novos
Serum activated leukocyte cell adhesion molecule and intercellular adhesion molecule-1 in patients with gastric cancer: Can ... Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell ... 5. Activated leukocyte cell adhesion molecule in breast cancer: prognostic indicator.. King JA; Ofori-Acquah SF; Stevens T; Al- ... 2. Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential Seed and Soil Receptor in the Peritoneal Metastasis of ...
Cell Adhesion Molecules, Neuron-Glia [D23.050.301.350.250.150] * Activated-Leukocyte Cell Adhesion Molecule [D23.050.301.350. ... Cell Adhesion Molecules, Neuron-Glia [D12.776.395.5220.127.116.11] * Activated-Leukocyte Cell Adhesion Molecule [D12.776. ... Cell Adhesion Molecules, Neuron-Glia [D12.776.543.518.104.22.168] * Activated-Leukocyte Cell Adhesion Molecule [D12.776. ... Activated-Leukocyte Cell Adhesion Molecule Preferred Concept UI. M0030062. Registry Number. 0. Scope Note. Cell adhesion ...
Human Leucocyte Differentiation Antigens) Workshops and names and characterises CD molecules. ... Human Cell Differentiation Molecules is an organisation which runs HLDA ( ... DESC: activated leukocyte cell adhesion molecule OTH_NAMES: CD166; MEMD CLONE_NAME. ISO_TYPE. SUBMITTER. AVAILABLE_FROM. ...
DailyMed - TYSABRI- natalizumab injection
Leukocyte migration across the BBB involves interaction between adhesion molecules on inflammatory cells and their counter- ... which is expressed on activated vascular endothelium, and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) present on ... The receptors for the α4 family of integrins include vascular cell adhesion molecule-1 (VCAM-1), ... In multiple sclerosis, lesions are believed to occur when activated inflammatory cells, including T-lymphocytes, cross the ...
Molecules | Free Full-Text | Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential...
... in all cell cultures. HAS2, HAS3 and HYAL1 expression in OFs also decreased (p = 0.009, p = 0.0005 and p = 0.015, respectively ... Ten ng/mL PDGF-BB increased HA production and fibroblast proliferation in all cell lines (p < 0.0001); GC treatment remained ... It is known that GCs can inhibit T-cell-activating cytokines and adhesion molecules, as well as proliferation and infiltration ... HC and DEX in cultured fibroblast-like synoviocytes and in leukocytes isolated from synovial fluid , as well as in ...
VCAM1 - Early...
vascular cell adhesion molecule 1. Description. VCAM1, a single-pass type I membrane protein belonging to the Ig superfamily, ... is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. It mediates leukocyte-endothelial cell ... VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 ... Entrez Protein Reference Sequence for vascular cell adhesion protein 1 isoform a precursor [Homo sapiens] ...
Molecular basis of sidekick-mediated cell-cell adhesion and specificity | eLife
2 reveal a single homodimer interaction mode responsible for both cell-cell recognition and cis-clustering, suggesting that ... Crystal structures of synaptic recognition molecules Sidekick-1 and - ... and activated leukocyte cell adhesion molecule (ALCAM) families (Chen et al., 2013). Crystal structures of the horseshoe ... 2010) Neural circuit formation in the cerebellum is controlled by cell adhesion molecules of the Contactin family Cell Adhesion ...
Activated-Leukocyte Cell Adhesion Molecule Entry term(s). ALCAM Activated Leukocyte Cell Adhesion Molecule Antigens, CD166 ... Activated-Leukocyte Cell Adhesion Molecule - Preferred Concept UI. M0030062. Scope note. Cell adhesion molecule expressed on ... NEUROLIN was indexed under CELL ADHESION MOLECULES, NEURONAL 1992-98; all are now ACTIVATED-LEUKOCYTE CELL ADHESION MOLECULE. ... Activated-Leukocyte Cell Adhesion Molecule Descriptor Spanish: Molécula de Adhesión Celular del Leucocito Activado Spanish from ...
Cell Adhesion Molecules, Neuron-Glia [D23.050.301.350.250.150] * Activated-Leukocyte Cell Adhesion Molecule [D23.050.301.350. ... Cell Adhesion Molecules, Neuron-Glia [D09.400.430.822.214.171.124] * Activated-Leukocyte Cell Adhesion Molecule [D09.400. ... Cell Adhesion Molecules, Neuron-Glia [D12.776.395.5126.96.36.199] * Activated-Leukocyte Cell Adhesion Molecule [D12.776. ... Cell Adhesion Molecules, Neuron-Glia [D12.776.543.5188.8.131.52] * Activated-Leukocyte Cell Adhesion Molecule [D12.776. ...
JCI Insight - Cardiovascular complications of COVID-19
... that function as cell adhesion molecules to recruit platelets and leukocytes (93). An exaggerated inflammatory response, with ... Activated ECs are hypercontractile, which can lead to disruption of cell-cell junctions and vascular leakage. ... SARS-CoV-2 and endothelial cell dysfunction. Direct damage to endothelial cells (ECs) caused by SARS-CoV-2 disrupts cell ... disruption of cell junctions, detachment of cells from the basement membrane, and cell swelling (89). ...
TotalSeq™-D0125 anti-human CD44 antibody, CD44, BJ18
... endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 ... Stem Cells Molecular Family Adhesion Molecules, CD Molecules Antigen References 1. Barclay AN, et al. 1997. The Leukocyte ... Endothelial cells, Epithelial cells, Leukocytes, Mesenchymal cells, Mesenchymal Stem Cells, Tregs Biology Area Cell Adhesion, ... It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or ...
DeCS - Termos Novos
DeCS - Termos Novos
سرطان سینه سه گانه منفی | دانلود مقالات ISI سرطان سینه سه گانه منفی | 186 مقاله انگلیسی + ترجمه فارسی
Activated leukocyte cell adhesion molecule; APOD; Apolipoprotein D; AR; androgen receptor; AURKA; Aurora kinase A; AURKB; ... T cells; Inflammation; Cell-nonautonomous; Tumor microenvironment; APC; antigen presenting cells; ATF6; activating ... Activating Transcription Factor 4; ATF6; Activating Transcription Factor 6; C/EBP; CCAAT / Enhancer binding proteins; CHOP; C/ ... Keywords: سرطان سینه سه گانه منفی; Calcitriol; Menadione; Triple negative breast cancer; In vivo tumor growth; Cell death; ...
Target Regulator(s) Information (MicroRNA) | Therapeutic Target Database
Activated leukocyte cell adhesionmolecule (ALCAM) Target Info CD166_HUMAN Dickkopf-related protein 1 (DKK1) Target Info DKK1_ ... Small Molecule Agents of Immunotherapy Targets * Multi-target Agents * Nature-derived Drugs ... DNA Cell Biol. 2013 Jun;32(6):302-9. REF 2. IL-1beta-mediated NF-B signaling augments the osteosarcoma cell growth through ... MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha. ...
Sickle Cell Disease Agents - LiverTox - NCBI Bookshelf
... and lessening of sickle cell adhesion to endothelial cells. ... Drugs for sickle cell disease include agents that increase ... Sickle cell disease is caused by an inherited mutation in the β globin gene that creates hemoglobin S, an abnormal form of ... hemoglobin which is prone to polymerization when exposed to low oxygen tension which results in sickling of red blood cells, ... sickling and agents that act downstream from sickling in preventing the microvascular occlusions due to the sickled red cells ...
... activated leukocyte cell adhesion molecule (ALCAM), are involved in T cell activation and trafficking. Previously, we showed ... Within the B cell linage, CD38 is expressed in diverse murine B cell subsets, with highest levels in innate B cell ... as well as by the numbers of activating and inhibitory FcÎ³Rs on the cell surface. A group of immune cells that has come into ... CD38A+ B cells had an increased IgM secreting capacity than that of cells lacking CD38A on the cell surface, also showing ...
NDF-RT Code NDF-RT Name
N0000169430 Actins N0000178878 Activated Charcoal N0000171267 Activated-Leukocyte Cell Adhesion Molecule N0000169867 Activating ... Sulfate N0000170311 Netropsin N0000171076 Neural Cell Adhesion Molecule L1 N0000171075 Neural Cell Adhesion Molecules ... axetil N0000007233 celecoxib N0000166834 Celiprolol N0000171065 Cell Adhesion Molecules N0000171077 Cell Adhesion Molecules, ... Neuron-Glia N0000171073 Cell Adhesion Molecules, Neuronal N0000170184 Cell Cycle Proteins N0000170929 Cell Extracts N0000169173 ...
NIH Guide: ALCOHOLIC HEPATITIS: CELLULAR AND MOLECULAR MECHANISMS
... adhesion molecules that promote the attachment of leukocytes to endothelial cells and hepatocytes; 5) the mechanisms of ... This results in increased amount of bacterial endotoxin in hepatic portal system, which activates Kupffer cells of the liver ... o Determination of the types and cellular sources of chemokines and adhesion molecules involved in attracting leukocytes and ... increased expression of adhesion molecules, and increased infiltration of inflammatory cells into the liver. These changes are ...
NIOSHTIC-2 Search Results - Full View
TNF-a then induces the expression of leukocyte adhesion molecules upon proximal septal capillary endothelium resulting in the ... Fe-treated macrophages raise vascular endothelial cells to an activated state as indicated by the induction of endothelial- ... leukocyte adhesion molecules ICAM-1, VCAM-1, and E-selectin. Finally, our observation that 100 nm particulates elicit much ... Cell-damage; Cell-function; Cellular-reactions; Cell-biology; Exposure-levels; Lung-disease; Respiratory-system-disorders; ...
Septic Shock: Practice Essentials, Background, Pathophysiology
Adhesion molecules. Enhance neutrophil-endothelial cell interaction, regulate leukocyte migration and adhesion, and play a role ... NO also activates potassium channels. Potassium efflux from cells results in hyperpolarization, inhibition of calcium influx, ... Adhesion molecules. Enhance neutrophil-endothelial cell interaction, regulate leukocyte migration and adhesion, and play a role ... cell counts, as well as total B-cell and T-cell counts.  ... molecules and T-cell receptors, leading to massive cytokine ...
Pesquisa | Portal Regional da BVS
Leukocyte adhesion and extravasation are mediated by adhesion molecules expressed by activated endothelial cells, like ... ß2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, ... ICAM-1 is a member of immunoglobulin-like superfamily of adhesion molecules that binds LFA-1 to mediate leukocytes adhesion and ... Intercellular adhesion molecule-1 (ICAM-1) is a member of an immunoglobulin-like superfamily of adhesion molecules that mediate ...
Heart Disease - Prevention and Treatment with a Plant-Based Diet - Plant-Based Diets in Medicine
... is an Ig-like cell adhesion molecule expressed by several cell types, including leukocytes and endothelial cells. It can be ... E-selectin (cE-Selectin) is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other ... E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro. Immunology. Dec ... leukocyte adhesion molecules under atherogenic conditions is accompanied by the release of soluble forms of adhesion molecules ...
1 - Cci divergence binary options strategy
1998) Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in ... Cell Cycle The cell cycle consists of a stationary GO phase, which, upon receipt of appropriate cell signals. Pichler, M. 9 min ... 57 Poly(ADP-ribosyl)ation of nuclear proteins in activated granulocytes was associated with an increase of adhe- sion, clutches ... 10 ). Sample Problem Problem Calculate the standard cell potential for the galvanic cell in which the following reaction occurs ...
COX-2 dependent inflammation increases spinal Fos expression during rodent postoperative ileus | Gut
We have also shown that leucocyte adhesion molecule blocking antibodies prevent the recruitment of monocytes, neutrophils, and ... cells into the muscularis of both rats and COX-2+/+ mice (rats: 92.6 (12.10) cells/field; COX-2+/+ mice: 58.7 (9.40) cells/ ... As bowel distension itself is known to activate visceral afferent neurones48 and we observed postoperative dilatation of the ... cells) and COX-2−/− mice (61.6 (8.3) cells), manipulated COX- 2−/− mice exhibited 49% fewer Fos IR neurones (77.9 (10.3 cells) ...
... activated lung and endothelial microparticles while having no effect on circulating levels of endothelial adhesion molecules, ... Hematopoietic Stem Cells/pathology; Inhalation Exposure; Leukocytes/drug effects; Leukocytes/metabolism; Leukocytes/pathology; ... Endothelial Cells/drug effects; Endothelial Cells/metabolism; Endothelial Cells/pathology; Hematopoietic Stem Cells/drug ... Levels of platelet-leukocyte aggregates, platelet macroparticles, and a proportion of CD4+ and CD8+ T-cells were also ...
ALCAMInflammationIntercellular adhesionVascularChemokinesCytokinesSelectinsAntibodiesICAMNeutrophilsMediateEndotheliumReceptorOverexpressionInterleukinExtracellularAntigenPlateletsEndothelial cellMigrationSubsetsMediatesInflammatoryMesenchymal StemImmunomodulatoryCD44ProteinInfiltrationImmunoglobulinContributesMonocytesCD18Developing and establishedEpithelialNeuronsInducesInduceExpressionAggregationStromal cells2017RegulationInteractsPeripheralAffectsLigandImmuneProteinsReactiveChronicBiologyLymphoidTissueBiolSickle cell diPromotesProliferationMediatorsInfectionSurfaceHemoglobinMononuclear cellsMacrophages
- Activated leukocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis. (nih.gov)
- 1. ALCAM, Activated Leukocyte Cell Adhesion Molecule, in Clinical Gastric Cancer and Patient's Response to Chemotherapies. (nih.gov)
- 2. Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers. (nih.gov)
- 6. Activated leukocyte cell adhesion molecule (ALCAM)/CD166 in pancreatic cancer, a pivotal link to clinical outcome and vascular embolism. (nih.gov)
- 7. Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma. (nih.gov)
- 9. ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression. (nih.gov)
- 10. ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. (nih.gov)
- 11. The role of activated leukocyte cell adhesion molecule (ALCAM) in cancer progression, invasion, metastasis and recurrence: A novel cancer stem cell marker and tumor-specific prognostic marker. (nih.gov)
- 13. Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. (nih.gov)
- 14. Modulation of cell adhesion and migration through regulation of the immunoglobulin superfamily member ALCAM/CD166. (nih.gov)
- 17. Expression of the cell to cell adhesion molecule, ALCAM, in breast cancer patients and the potential link with skeletal metastasis. (nih.gov)
- 18. Prognostic Impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM/CD166) in Infantile Neuroblastoma. (nih.gov)
- ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes. (nih.gov)
- Las interacciones ALCAM-CD6 pueden jugar un papel en la unión de las células T y B a los leucocitos activados. (bvsalud.org)
- The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. (nih.gov)
- CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation. (biolegend.com)
- o Determination of the types and cellular sources of chemokines and adhesion molecules involved in attracting leukocytes and their attachments at different stages of inflammation. (nih.gov)
- Atherosclerosis is a chronic, inflammatory disease of the vessel wall where triggered immune cells bind to inflamed endothelium, extravasate and sustain local inflammation. (bvsalud.org)
- 2, 3 Inflammation is also implicated in the pathogenesis of acute syndromes, as suggested by histological findings in unstable coronary plaques, 4- 6 evidence of systemic release of thromboxanes and leukotrienes, 7- 9 and the presence of activated circulating leucocytes. (bmj.com)
- A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. (nih.gov)
- As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. (nih.gov)
- HopQ-CEACAM interactions may also utilize T4SS, instead of CagA, to activate NF-κB signaling and trigger inflammation. (ac.ir)
- Summary PSGL-1 is the best-studied selectin ligand and has become a posterchild of versatility in leukocyte adhesion, inflammation and immunology. (elsevierpure.com)
- 12. Serum activated leukocyte cell adhesion molecule and intercellular adhesion molecule-1 in patients with gastric cancer: Can they be used as biomarkers? (nih.gov)
- Leukocyte adhesion and extravasation are mediated by adhesion molecules expressed by activated endothelial cells, like intercellular adhesion molecule 1 (ICAM-1). (bvsalud.org)
- VCAM1 is expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. (nih.gov)
- Sickle cell disease is caused by an inherited mutation in the β globin gene that creates hemoglobin S, an abnormal form of hemoglobin which is prone to polymerization when exposed to low oxygen tension which results in sickling of red blood cells, hemolytic anemia, vascular occlusion of small vessels, ischemic tissue and organ injury and recurrent painful crises. (nih.gov)
- Most of the complications of sickle cell disease are due to the vaso-occlusive crises caused the aggregates of sickled red cells, platelets, leukocytes adhering to endothelial cells and causing vascular stasis and ischemic injury to tissues. (nih.gov)
- Furthermore, clarified culture supernatants recovered from C- Fe-treated macrophages raise vascular endothelial cells to an activated state as indicated by the induction of endothelial- leukocyte adhesion molecules ICAM-1, VCAM-1, and E-selectin. (cdc.gov)
- Endothelial dysfunction is now regarded as an regulation, vascular smooth cell proliferation, early pivotal event in atherogenesis 2 and has trans endothelial leukocyte migration, been shown to precede development of clinically thrombosis and thrombolytic balance. (who.int)
- B-CLL cells bound normally to vascular endothelium, but binding to IL-1-activated endothelium was significantly lower than that of normal peripheral blood lymphocytes. (kingston.ac.uk)
- This activation initiates a cascade of events leading to increased generation of free radicals, activation of nuclear transcription factor-kB (NF-kB), increased transcription of inflammatory cytokines and chemokines, increased expression of adhesion molecules, and increased infiltration of inflammatory cells into the liver. (nih.gov)
- Can blocking the synthesis of chemokines and adhesion molecules arrest the inflammatory process? (nih.gov)
- PSGL-1 also plays a crucial role in T-cell homeostasis by binding to lymphoid chemokines, and can induce tolerance by enhancing the functions of regulatory T cells. (elsevierpure.com)
- Recent findings PSGL-1 was originally described as a leukocyte ligand for P-selectin, but it is actually a ligand for all selectins (P-, L-and E-selectin), binds chemokines, activates integrins and profoundly affects T-cell biology. (elsevierpure.com)
- Complement plays an important role in the direct defense to pathogens, but can also activate immune cells and the release of pro-inflammatory cytokines. (bvsalud.org)
- 16, 17 The leucocyte count and various inflammatory proteins such as fibrinogen, 18, 19 plasminogen activator inhibitor (PAI-1), 16 von Willebrand factor, 20 albumin, 18 and various cytokines and adhesion molecules have been found to be independently associated with cardiovascular end points. (bmj.com)
- Patterns of adhesion molecule expression and their regulation by cytokines may underly some of the clinical features of this disease. (kingston.ac.uk)
- Other workers and ourselves have found that cell-cell contact is an important signal for the induction of cytokines, and our work has demonstrated that tumour necrosis factor and IL-10 production in rheumatoid arthritis synovial joint cells cultures is dependent on T cell/macrophage interaction. (biomedcentral.com)
- Importantly, we observed that the manner in which T cells were activated influenced the profile of cytokines induced in the monocytes. (biomedcentral.com)
- However, if the T cells were stimulated with a cocktail of cytokines (TNF-α, IL-2 and IL-6) for 8 days (bystander activation), TNF-α production followed but IL-10 production did not [ 11 ]. (biomedcentral.com)
- Fc-induced creation of cytokines by NK cells revealed to rituximab-coated M cell focuses on was also improved by ADAM17 inhibition. (academicediting.org)
- Compact disc56dim NK cells, nevertheless, are cytotoxic without enjoyment potently, mediate antibody reliant mobile cytotoxicity of a disintegrin and metalloprotease-17 (ADCC), and generate cytokines after enjoyment with focus on cells. (academicediting.org)
- Benzene inhalation significantly increased the biomarkers of endothelial activation and injury including endothelial microparticles, activated endothelial microparticles, endothelial progenitor cell microparticles, lung endothelial microparticles, and activated lung and endothelial microparticles while having no effect on circulating levels of endothelial adhesion molecules, endothelial selectins, and biomarkers of angiogenesis. (nih.gov)
- TotalSeq™-D antibodies are compatible with Mission Bio's Tapestri Single-Cell Sequencing Platform for simultaneous detection of DNA and Protein. (biolegend.com)
- We have also shown that leucocyte adhesion molecule blocking antibodies prevent the recruitment of monocytes, neutrophils, and mast cells into the muscularis and also avert postoperative jejunal muscle dysfunction. (bmj.com)
- Inhibitor studies using antisense and sense oligodeoxynucleotides against mRNAs of iNOS and TNF-alpha, antibodies against adhesion molecules suggested that interactions via CD18 and ICAM-1 leads to activation and mediator production of Kupffer cells cocultured with hepatoma cells. (nii.ac.jp)
- Extracellular adherence protein (Eap) from Staphylococcus aureus binds to a plethora of extracellular matrix proteins, including ICAM-1 and its ligands macrophage-1 antigen (Mac-1, αMß2) and lymphocyte function-associated antigen 1 (LFA-1, αLß2), thereby disrupting the interaction between leukocytes and endothelial cells. (bvsalud.org)
- Kupffer cell-mediated mitochondrial dysfunction in hepatoma cells by production of nitric oxide and the involvement of ICAM-1/LFA-1 molecules in their contact :' Int Immunol. (nii.ac.jp)
- CD18/ICAM-1-dependent nitric oxide production of Kupffer cells as a cause of mitochondrial dysfunction in hepatoma cells : Influence of chronic alcohol feeding. (nii.ac.jp)
- o Elucidation of the mechanisms by which neutrophils, monocytes and lymphocytes are activated in hepatic sinusoids, attach to endothelial cells, and pass through the cell lining into the hepatic parenchyma. (nih.gov)
- In developing atherosclerosis, Eap treatment reduced circulating platelet-neutrophil aggregates as well as infiltration of T cells and neutrophils into the growing plaque, accompanied by reduced formation of neutrophil extracellular traps (NETs). (bvsalud.org)
- Sdks mediate cell-cell adhesion with homophilic specificity that underlies their neuronal targeting function. (elifesciences.org)
- Importantly, HIV-infected cell present in all fluid vectorizing the infection, such as semen or cervical vaginal secretion, mediate efficient penile entry where cell-free viruses is not efficient. (nih.gov)
- Mg(2+)-dependent ligand binding does not affect binding of Ca2+ by LFA-1 as measured by NKI-L16 expression, suggesting that Mg2+ binds to a distinct site, and that both cations are important to mediate adhesion. (rupress.org)
- VCAM1, a single-pass type I membrane protein belonging to the Ig superfamily, is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. (nih.gov)
- TNF-a then induces the expression of leukocyte adhesion molecules upon proximal septal capillary endothelium resulting in the recruitment of inflammatory leukocytes to the site. (cdc.gov)
- This results in increased amount of bacterial endotoxin in hepatic portal system, which activates Kupffer cells of the liver via the CD14 surface receptor. (nih.gov)
- This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. (nih.gov)
- Intro Organic great (NK) cells are described by the appearance of the cell adhesion gun Compact disc56 and absence of the T-cell receptor Compact disc3 (Compact disc56+Compact disc3? (academicediting.org)
- A 30 kDa stimulatory receptor found on resting and activated NATURAL KILLER CELLS. (rush.edu)
- 4. Overexpression of activated leukocute cell adhesion molecule in gastric cancer is associated with advanced stages and poor prognosis and miR-9 deregulation. (nih.gov)
- Interestingly, in human kidney (HK-2) cells, overexpression of TIMP2 caused ER stress, whereas TIMP2 knockdown attenuated lipopolysaccharide-induced ER stress and apoptosis. (bvsalud.org)
- The overexpression of these molecules may contribute to cancer progression and relapse. (ac.ir)
- H. pylori may use these HopQ-CEACAM interactions to transfer its CagA oncoprotein into host gastric epithelial cells, which is followed by its phosphorylation and release of interleukin-8. (ac.ir)
- Transition of leukocyte function-associated antigen-1 (LFA-1), from an inactive into an activate state depends on the presence of extracellular Mg2+ and/or Ca2+ ions. (rupress.org)
- Drugs for sickle cell disease target the prevention of sickle cell formation, but also the subsequent vaso-occlusive crises which is the result of the sickled cells forming aggregates with platelets and leukocytes that adhere to microvascular endothelial cells causing obstruction and local ischemic damage. (nih.gov)
- The Sickled-shaped erythrocytes together with endothelial cells, activated leukocytes, platelets and plasma proteins participate in the multistep vaso-occlusion process (Frenette 2002). (justia.com)
- It mediates leukocyte-endothelial cell adhesion and signal transduction. (nih.gov)
- The presence of preexisting cardiovascular disease increases mortality in patients with COVID-19, and cardiovascular injuries, including myocarditis, cardiac rhythm abnormalities, endothelial cell injury, thrombotic events, and myocardial interstitial fibrosis, are observed in some patients with COVID-19. (jci.org)
- 16. Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration. (nih.gov)
- miR-152 Controls Migration and Invasive Potentialby Targeting TGFa in Prostate Cancer Cell Lines. (idrblab.net)
- Appropriate topics for investigation under this PA would include, but are not limited to: o Investigation of the mechanisms by which Kupffer cell-generated inflammatory mediators injure endothelial cells and hepatocytes, and stimulate migration of leukocytes into hepatic parenchyma. (nih.gov)
- ß2-integrins (CD11a-d/CD18) play important roles in the migration of leukocytes into inflamed tissues and cell signaling. (bvsalud.org)
- Up-regulation of MiR-1915 inhibits proliferation, invasion, and migration of Helicobacter pylori-infected gastric cancer cells via targeting RAGE. (ac.ir)
- Thus, CD44 has been reported to be a valuable marker for memory cell subsets. (biolegend.com)
- NK cells can become divided into 2 functionally specific subsets, CD56dim and CD56bright, centered on the cell surface area denseness of Compact disc56.1 Comprising approximately 10% of circulating NK cells, Compact disc56bcorrect NK 169545-27-1 IC50 cells are generally thought to be more proliferative, to possess a higher capability for cytokine creation after enjoyment with IL-18 and IL-12, and to possess poor cytotoxic effector activity at rest. (academicediting.org)
- In conclusion, in patients who died from SARS-CoV-2 infection complement was activated in both lungs and kidneys indicating that complement might be involved in systemic worsening of the inflammatory response. (bvsalud.org)
- Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs : role of leukocytes. (nii.ac.jp)
- HopQ of H. pylori may interact with CEACAMs of the human gastric cells to induce the development of gastric ulcers and cancers by transferring CagA oncoprotein or inducing activation of T4SS to initiate and maintain inflammatory reactions. (ac.ir)
- Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal lineages. (giostar.com)
- Mesenchymal stem cells (MSCs), also known as multipotent mesenchymal stromal cells, are self-renewing cells which can be found in almost all postnatal organs and tissues [ 3 , 4 ]. (giostar.com)
- MSCs secrete various immunomodulatory molecules which provide a regenerative microenvironment for a variety of injured tissues or organ to limit the damage and to increase self-regulated tissue regeneration. (giostar.com)
- Here, we focus on T cells, because PSGL-1 was recently described as a major immunomodulatory molecule during viral infection. (elsevierpure.com)
- As B and T cells become activated or progress to the memory stage, CD44 expression increases from a low or mid level of intensity to high expression levels. (biolegend.com)
- B-CLL cells express high levels of CD44, but expression of the leucocyte integrins was low or absent, while expression of VLA-4 is high. (kingston.ac.uk)
- TotalSeq™-D reagents are designed to profile protein expression at single cell level. (biolegend.com)
- We further established the method by which activated NF-kappaB can be visualized (Fluorescence in situ DNA-protein binding assay). (nii.ac.jp)
- Reductive evolution in outer membrane protein biogenesis has not compromised cell surface complexity in Helicobacter pylori. (ac.ir)
- Histopathologically, it is characterized by liver cell death and infiltration of leukocytes into the hepatic parenchyma. (nih.gov)
- Intervention treatment with Eap of already established plaques did not result in cellular or morphological plaque changes, whereas T cell infiltration was increased and thereby again modulated by Eap. (bvsalud.org)
- Cell surface expression of adhesion molecules in B-cell chronic lymphocytic leukemia (B-CLL) may determine the patterns of dissemination and infiltration. (kingston.ac.uk)
- Sidekick (Sdk) 1 and 2 are related immunoglobulin superfamily cell adhesion proteins required for appropriate synaptic connections between specific subtypes of retinal neurons. (elifesciences.org)
- Some aspects of this specific connectivity appear to be mediated by recognition molecules of the immunoglobulin superfamily (IgSF). (elifesciences.org)
- 8. Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer. (nih.gov)
- Thus, if blood T cells were activated with cross-linked anti-CD3, this induced the production of TNF-α and IL-10 in monocytes [ 12 ]. (biomedcentral.com)
- In humans, loss-of-function mutations in the common subunit CD18 result in leukocyte adhesion deficiency type-1 (LAD-1). (bvsalud.org)
- However, since a constitutive knockout affects all leukocytes and may limit the validity of studies focusing on their cell type-specific role, we established a Treg-specific CD18-floxed mouse strain. (bvsalud.org)
Developing and established1
- We aimed to use Eap to inhibit the interaction of leukocytes with activated endothelial cells in settings of developing and established atherosclerosis in apolipoprotein E (ApoE) deficient mice on high-fat diet. (bvsalud.org)
- Therefore, we reconstructed urethral mucosa made of fibroblast macrophages overlaid by urethral epithelial cell, and after 17 days, the reconstruction polarized was inserted into microscopic device and inoculated in situ with gag-GFP-HIV-infected T cell producing GFP viruses or with cell-free viruses. (nih.gov)
- Next, by observing live imaging recording was -- we could measure that the time required for the infected T cell to form a productive synapse with epithelial, which lasts approximately a half an hour before the T cell is able to shed virus for another hour and leave its site of (inaudible) as you just show. (nih.gov)
- Human CEACAMs are the cell surface adhesion molecules mainly present on the epithelial cells, endothelial cells and leukocytes. (ac.ir)
- Cell adhesion molecule expressed on activated leukocytes, fibroblasts, and neurons. (nih.gov)
- Rat Kupffer cell-derived nitric oxide suppresses proliferation and induces apoptosis of syngeneic hepatoma cells. (nii.ac.jp)
- Iron-containing particles have been proposed as a mechanism of introducing unregulated iron into cells, and soluble iron has been shown to induce the expression ofTNF-a in Kupffer cells, which was preceded by an increase in hydroxyl radicals. (cdc.gov)
- To understand how benzene may induce endothelial injury, we exposed human aortic endothelial cells to benzene metabolites. (nih.gov)
- Only Sr2+ ions can replace Ca2+ to express the L16 epitope, and to induce clustering of LFA-1 at the cell surface. (rupress.org)
- Investigations using these techniques revealed that coculture of Kupffer cells and hepatoma cells stimulate productions of NO and TNF-alpha, and these mediators released from Kupffer cells synergistically induce apoptosis of hepatoma cells. (nii.ac.jp)
- Consistent with this, tumor growth was significantly reduced in PSGL-1-deficient mice because of an enhanced number of effector T cells together with reduced levels of inhibitory receptors that induce T-cell exhaustion. (elsevierpure.com)
- Ward J, Bonaparte M, Sacks J, Guterman J, Fogli M, Mavilio D, Barker E. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. (rush.edu)
- Structure-guided mutagenesis results show that this canonical dimer is required for both Sdk-mediated cell aggregation (via trans interactions) and Sdk clustering in isolated cells (via cis interactions). (elifesciences.org)
- firstly described a method for MSCs (referred as "stromal cells") isolation from whole bone marrow aspirates based on differential adhesion properties. (giostar.com)
- In late 1980s Owen and Friedenstein reported heterogeneity of the bone marrow stromal cells for the first time [ 7 , 8 ]. (giostar.com)
- Bone marrow stromal cells were further characterized and named mesenchymal stem cell to describe the subtype of marrow stromal cells involved in the process of mesengenesis [ 9 , 10 ]. (giostar.com)
- L-glutamine was approved for use in sickle cell disease in 2017 but has not had widespread use. (nih.gov)
- Cell Host Microbe 2017, 21: 376-389. (ac.ir)
- Abadier, M & Ley, K 2017, ' P-selectin glycoprotein ligand-1 in T cells ', Current Opinion in Hematology , vol. 24, no. 3, pp. 265-273. (elsevierpure.com)
- 19. Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancer. (nih.gov)
- Jewell, A P and Yong, K L (1997) Regulation and function of adhesion molecules in B-cell chronic lymphocytic leukaemia. (kingston.ac.uk)
- We conclude that Ca2+ is involved in avidity regulation of LFA-1 by clustering of LFA-1 molecules at the cell surface, whereas Mg2+ is important in regulation of the affinity of LFA-1 for its ligands. (rupress.org)
- In contrast to other adhesins, HopQ interacts with host cell surface molecules in a glycan independent manner. (ac.ir)
- o Exploration of the mechanisms of peripheral blood mononuclear cell activation in response to chronic ethanol ingestion. (nih.gov)
- Regulatory T cells (Treg) are essential for the maintenance of peripheral tolerance. (bvsalud.org)
- We have studied T cell/monocyte cognate interactions using cells isolated from the peripheral blood of normal donors. (biomedcentral.com)
- Many Compact disc56bcorrect NK cells in the peripheral bloodstream communicate small to no Compact disc16A. (academicediting.org)
- Components and strategies Donor test remoteness Peripheral bloodstream mononuclear cells (PBMCs) had been separated on a ficoll-hypaque lean from healthful contributor and Compact disc56+Compact disc3? (academicediting.org)
- Sickle cell disease affects at least 100,000 Americans and is most common in persons of African descent. (nih.gov)
- Although Mg2+ is directly involved in ligand binding, the role of Ca2+ in LFA-1 mediated adhesion remained obscure. (rupress.org)
- We now demonstrate that binding of Ca2+, but not Mg2+, directly correlates with clustering of LFA-1 molecules at the cell surface of T cells, thereby facilitating LFA-1-ligand interaction. (rupress.org)
- Purpose of review We review P-selectin glycoprotein ligand-1 (PSGL-1) as a selectin and chemokine-binding adhesion molecule. (elsevierpure.com)
- However, in critically ill patients with COVID-19 the immune system is inadequately activated leading to severe acute respiratory syndrome (SARS) and acute kidney injury, which is associated with higher mortality. (bvsalud.org)
- Moreover, their ability to modulate immune responses makes them an even more attractive candidate for regenerative medicine as allogeneic transplant of these cells is feasible without a substantial risk of immune rejection. (giostar.com)
- Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
- Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)
- 57 Poly(ADP-ribosyl)ation of nuclear proteins in activated granulocytes was associated with an increase of adhe- sion, clutches, pulleys and other disc-shaped Constructional details of the engine 55 3. (forexsanity.com)
- one type, Compact disc16A, is normally a transmembrane proteins that co-localizes with Fc-RI- and Compact disc3 on NK cells. (academicediting.org)
- The activation of XO and reduced Tetrahydrobiopterin (BH 4 ) levels in endothelial cells leads to increased reactive oxygen species (ROS) formation, which in turn leads to endothelial nitric oxide synthase (eNOS) uncoupling and further production of superoxide (Thomas, et al 2010). (justia.com)
- A non-pharmacologic approach to management of sickle cell anemia is chronic transfusions to raise the hemoglobin level and provide normal hemoglobin and its oxygen carrying ability. (nih.gov)
- In addition, chronic therapy with hydroxyurea has a beneficial effect in sickle cell disease by increasing fetal hemoglobin synthesis (hemoglobin F) which provides a proportion of normal oxygen carrying hemoglobin. (nih.gov)
- Chronic therapy with hydroxyurea can decrease sickling and increase hemoglobin levels, with a decrease in vaso-occlusive crises and improvement in general well-being in individuals with sickle cell disease. (nih.gov)
- However, the uncertainty or fluctuation of single-cell transcriptome dynamics during differentiation was not considered, and the dendritic cell (DC) pathway in the lymphoid context remains unclear. (bvsalud.org)
- The tissue levels of endogenous antioxidants are often deficient in sickle cell disease and can be increased by L-glutamine intake. (nih.gov)
- Stem cells are immature tissue precursor cells which are able to self-renew and differentiate into multiple cell lineages [ 1 , 2 ]. (giostar.com)
- And using ex vivo explant infection as well as reconstruction infection -- mucosal reconstruction infection, we have shown that HIV can penetrate by two pathway to penetrate the penile tissue, first through the foreskin where HIV target Langerhans cells trans-infect CD4 T cell. (nih.gov)
- When the reconstruction was observed by spinning disc live imaging, as you can see here, T cell adhere to the surface of the epithelium, forming virology synapse able to shed burst of viral particle that will penetrate inside the tissue. (nih.gov)
- Histological studies of synovium in RA have indicated that this tissue is very cellular, and that several different cell types including macrophages and T cells are in close proximity [ 6 ]. (biomedcentral.com)
Sickle cell di8
- Drugs for sickle cell disease include agents that increase fetal hemoglobin, which has a higher affinity for oxygen and can decrease sickling and agents that act downstream from sickling in preventing the microvascular occlusions due to the sickled red cells by inhibition of hemoglobin S polymerase, decreasing oxidative stress, and lessening of sickle cell adhesion to endothelial cells. (nih.gov)
- Medications specifically approved for use in sickle cell disease include hydroxyurea, L-glutamine, voxelotor and crizanlizumab all of which act on a different target in the pathway of vaso-occlusive crises. (nih.gov)
- Hydroxyurea was approved for use in sickle cell disease in 1998 and is considered a first line therapy in management of this disease. (nih.gov)
- L-glutamine appears to act in decreasing painful crises in sickle cell disease by increasing levels of nicotinamide adenine dinucleotide (NAD) and glutathione, essential molecules in intracellular oxidative-reductive balance and metabolism. (nih.gov)
- The present invention includes embodiments for treatment and/or prevention of sickle cell disease that employ Hydroxyfasudil or Isocoronarin D alone or either in conjunction with each other or an inducer of HbF production. (justia.com)
- In particular aspects, the field of the present invention includes treatment and/or prevention of a blood disorder, such as sickle cell disease. (justia.com)
- Sickle cell disease (SCD) is the most common life-threatening monogenic disorder in the world with statistics indicating that approximately 80% (230,000) of children affected globally are born in sub-Saharan Africa (Modell and Darlison 2008). (justia.com)
- Sickle cell disease (SCD) can arise from a single point mutation that causes erythrocyte deformation or sickle-shaped erythrocytes (Ingram 1957). (justia.com)
- Absence of PSGL-1 promotes effector CD4 and CD8 T-cell differentiation and prevents T-cell exhaustion. (elsevierpure.com)
- MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha. (idrblab.net)
- The "response to injury" hypothesis postulates that endothelial dysfunction represents the initial step of atherogenesis and can be induced by haemodynamic forces, by a variety of vasoactive substances, by mediators from blood cells, and directly from risk factors for atherosclerosis. (bmj.com)
- We noticed that weak binding of Ca2+ is associated with a dispersed LFA-1 surface distribution on T cells and with non-responsiveness of these cells to stimuli known to activate LFA-1. (rupress.org)
- Our results demonstrate that over-activation of ADAM17 in NK cells may become harmful to their effector features by down-regulating surface area appearance of Compact disc16 and Compact disc62L. (academicediting.org)
- 12-14 This procedure might end up being essential for speedy modulation of the surface area thickness of Compact disc16A, and in convert the account activation effector and position function of NK cells. (academicediting.org)
- Ectodomain getting rid of is normally a proteolytic procedure that adjusts the cell surface area thickness of several cell surface area elements on leukocytes. (academicediting.org)
- The most common type of SCD is sickle cell anemia (SCA) (also referred to as HbSS or SS disease or hemoglobin S) in which there is homozygosity for the mutation that causes HbS. (justia.com)
- This process of self-assembly (polymerization) generates the sickled hemoglobin molecule (HbS) that damages the membrane and cytoskeleton of the erythrocyte. (justia.com)
- We have found that TNF-α production in RA synovium is T-cell dependent, as removal of CD3-positive T cells from RA synovial mononuclear cells resulted in significant reduced macrophage TNF-α production [ 7 ]. (biomedcentral.com)