Activated-Leukocyte Cell Adhesion Molecule: Cell adhesion molecule expressed on activated leukocytes, fibroblasts, and neurons. It is a ligand for CD6. ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes.Fetal Proteins: Proteins that are preferentially expressed or upregulated during FETAL DEVELOPMENT.Cell Adhesion Molecules, Neuronal: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.Lentigo: Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).Cell Adhesion: Adherence of cells to surfaces or to other cells.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Neural Cell Adhesion Molecules: Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Vascular Cell Adhesion Molecule-1: Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)Neural Cell Adhesion Molecule L1: A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.Intercellular Adhesion Molecule-1: A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.Cell Migration Assays, Leukocyte: Assays that measure the rate of migration of LEUKOCYTES. They may involve a variety of techniques such as measuring the movement of leukocytes through substrates such as AGAROSE gels or the rate of exit of cells from a glass capillary.
(1/109) Distribution and function of the adhesion molecule BEN during rat development.

It is well established that the notochord influences the development of adjacent neural and mesodermal tissue. Involvement of the notochord in the differentiation of the dorsal pancreas has been demonstrated. However, our knowledge of the signals involved in pancreatic development is still incomplete. In order to identify proteins potentially implicated during pancreatic differentiation, we raised and characterized monoclonal antibodies against previously established embryonic pancreatic ductal epithelial cell lines (BUD and RED). Using the MAb 2117, the cell surface antigen 2117 (Ag 2117) was cloned. The predicted sequence for Ag 2117 is the rat homologue of BEN. Initially reported as a protein expressed on epithelial cells of the chicken bursa of Fabricius, BEN is expressed in a variety of tissues during development and described as a marker for the developing central and peripheral chicken nervous systems. A role has been suggested for BEN in the adhesion of stem cells and progenitor cells to the blood-forming tissue microenvironment. In this study, we demonstrate that BEN, initially expressed exclusively in the notochord during the early development of rat, is implicated in pancreatic development. We show that Ag 2117 regulates the pancreatic epithelial cell growth through the ras and Jun kinase pathways. In addition, we demonstrate that Ag 2117 is able to regulate the expression of the transcription factor PDX1, required for insulin gene expression, in embryonic pancreas organ cultures.  (+info)

(2/109) Extracellular matrix-associated protein Sc1 is not essential for mouse development.

Sc1 is an extracellular matrix-associated protein whose function is unknown. During early embryonic development, Sc1 is widely expressed, and from embryonic day 12 (E12), Sc1 is expressed primarily in the developing nervous system. This switch in Sc1 expression at E12 suggests an importance for nervous-system development. To gain insight into Sc1 function, we used gene targeting to inactivate mouse Sc1. The Sc1-null mice showed no obvious deficits in any organs. These mice were born at the expected ratios, were fertile, and had no obvious histological abnormalities, and their long-term survival did not differ from littermate controls. Therefore, the function of Sc1 during development is not critical or, in its absence, is subserved by another protein.  (+info)

(3/109) Evidence for the expression of a second CD6 ligand by synovial fibroblasts.

OBJECTIVE: CD6, a cell surface glycoprotein expressed primarily on T cells, may function as a costimulatory molecule and may play a role in autoreactive immune responses. Recently, a CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule [ALCAM]) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. However, the results of functional studies have suggested the existence of a second CD6 ligand. The present study was undertaken to seek evidence for a second CD6 ligand on cultured synovial fibroblasts. METHODS: Flow cytometric and biochemical techniques were applied, using anti-CD166 monoclonal antibody (mAb) and a recombinant CD6 fusion protein, to determine whether cultured synovial fibroblasts and other cell types expressed a non-ALCAM CD6 ligand. RESULTS: CD14- fibroblastic synoviocytes showed greater binding of a recombinant CD6 fusion protein than of anti-ALCAM mAb. With interferon-gamma treatment of synovial fibroblasts, binding of both reagents increased, but this was more marked for binding of CD6 fusion protein. Exposure of synovial fibroblasts to other cytokines or to the superantigen staphylococcal enterotoxin A also regulated binding of CD6 fusion protein and anti-ALCAM mAb in a discordant manner. Immunoprecipitation of proteins from membrane extracts of synovial fibroblasts with a CD6-Ig fusion protein revealed a novel 130-kd band distinct from CD166; an identical molecule was also precipitated from membranes of HBL-100 tumor cells. CONCLUSION: Taken together with previous data regarding CD6 and CD166 function, the present findings strongly suggest the existence of a second CD6 ligand distinct from CD166, which can be expressed by synovial fibroblasts as well as other cells.  (+info)

(4/109) Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin.

Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions reveals that ALCAM expression correlates with melanoma progression. Most nevi (34/38) and all thin melanomas studied (Clark levels I and II) did not express ALCAM. In contrast, immunoreactivity was detected in the invasive, vertical growth phase of 2 of the 13 Clark level III lesions tested. The fraction of positive lesions further increased in Clark level IV (13/19) and in Clark level V (4/4) lesions. ALCAM expression was exclusively detectable in the vertical growth phase of the primary tumor. In melanoma metastases, approximately half of the lesions tested (13/28) were ALCAM positive. According to the Breslow-thickness, ALCAM expression was observed in less than 10% of the lesions that were thinner than 1.5 mm and in over 70% of the lesions that were thicker than 1.5 mm. Our results strongly suggest that ALCAM plays an important role in melanocytic tumor progression and depict it as a new molecular marker for neoplastic progression of primary human melanoma.  (+info)

(5/109) DM-GRASP is necessary for nonradial cell migration during chick diencephalic development.

Cell migration is fundamental to normal CNS development. Radial migration, along radial glial fibers, has been the principal pathway studied, however, nonradial or tangential cell migration has increasingly been identified at all levels of the CNS. Receptors, cell adhesion molecules, and extracellular matrix molecules have all been shown to participate in radial cell migration. In contrast, the molecular basis of nonradial cell migration has only recently begun to be elucidated. Using replication defective retroviral vectors we have determined the location and time when nonradial cell migration begins in the developing chick diencephalon. We have identified three molecules that are expressed in spatially and temporally restricted domains that are consistent with them playing a role in nonradial cell migration. One of these molecules, DM-GRASP, a transmembrane protein with five extracellular Ig domains, is expressed on the nonradially migrating cells in addition to axons. To test the hypothesis that DM-GRASP participates in guiding nonradial cell migration, we injected a replication-defective retroviral vector used for lineage tracing followed by a DM-GRASP blocking antibody. Embryos injected with the blocking antibody showed a near complete block in nonradial cell migration specifically where DM-GRASP is expressed. Furthermore, morphological analyses revealed disruption of the normal architecture of the diencephalon indicating nonradial cell migration is necessary for normal morphological development of the brain. Our data indicate that DM-GRASP is necessary for nonradial cell migration in the chick diencephalon and have provided a system to further explore the function of nonradial cell migration during CNS development.  (+info)

(6/109) Dynamic regulation of activated leukocyte cell adhesion molecule-mediated homotypic cell adhesion through the actin cytoskeleton.

Restricted expression of activated leukocyte cell adhesion molecule (ALCAM) by hematopoietic cells suggests an important role in the immune system and hematopoiesis. To get insight into the mechanisms that control ALCAM-mediated adhesion we have investigated homotypic ALCAM-ALCAM interactions. Here, we demonstrate that the cytoskeleton regulates ALCAM-mediated cell adhesion because inhibition of actin polymerization by cytochalasin D (CytD) strongly induces homotypic ALCAM-ALCAM interactions. This induction of cell adhesion is likely due to clustering of ALCAM at the cell surface, which is observed after CytD treatment. Single-particle tracking demonstrated that the lateral mobility of ALCAM in the cell membrane is increased 30-fold after CytD treatment. In contrast, both surface distribution and adhesion of a glycosylphosphatidylinositol (GPI)-anchored ALCAM mutant are insensitive to CytD, despite the increase in lateral mobility of GPI-ALCAM upon CytD treatment. This demonstrates that clustering of ALCAM is essential for cell adhesion, whereas enhanced diffusion of ALCAM alone is not sufficient for cluster formation. In addition, upon ligand binding, both free diffusion and the freely dragged distance of wild-type ALCAM, but not of GPI-ALCAM, are reduced over time, suggesting strengthening of the cytoskeleton linkage. From these findings we conclude that activation of ALCAM-mediated adhesion is dynamically regulated through actin cytoskeleton-dependent clustering.  (+info)

(7/109) Expression of DM-GRASP/BEN in the developing mouse spinal cord and various epithelia.

The expression pattern of the immunoglobulin DM-GRASP/BEN gene was studied in the mouse embryo using in situ hybridization. DM-GRASP/BEN is expressed in the spinal cord in a subset of motoneurons expressing Islet-1, and non homogeneously in the dorsal root ganglia (DRG). In contrast, it's expression is homogeneous in the vestibulo-cochlear and trigemminal ganglia. DM-GRASP/BEN is also expressed in various epithelia of ectodermal or endodermal origin like the nasal, buccopharyngal and lung epithelia. In upper lip, DM-GRASP/BEN transcripts are present in the epidermal cells of the developing hair vibrissa follicles. First detected in the hair placode, DM-GRASP/BEN expression is localized in the central cells of the epithelial hair peg and then in a thin layer of cells crushed against the outer root sheath by the outgrowth of the hair shaft.  (+info)

(8/109) A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells.

In lower vertebrates, retinal ganglion cells (RGCs) can regenerate their axons and reestablish functional connections after optic nerve injury. We show here that in goldfish RGCs, the effects of several trophic factors converge on a purine-sensitive signaling mechanism that controls axonal outgrowth and the expression of multiple growth-associated proteins. In culture, goldfish RGCs regenerate their axons in response to two molecules secreted by optic nerve glia, axogenesis factor-1 (AF-1) and AF-2, along with ciliary neurotrophic factor. The purine analog 6-thioguanine (6-TG) blocked outgrowth induced by each of these factors. Previous studies in PC12 cells have shown that the effects of 6-TG on neurite outgrowth may be mediated via inhibition of a 47 kDa protein kinase. Growth factor-induced axogenesis in RGCs was accompanied by many of the molecular changes that characterize regenerative growth in vivo, e.g. , increased expression of GAP-43 and certain cell surface glycoproteins. 6-TG inhibited all of these changes but not those associated with axotomy per se, e.g., induction of jun family transcription factors, nor did it affect cell survival. Additional studies using RGCs from transgenic zebrafish showed that expression of Talpha-1 tubulin is likewise stimulated by AF-1 and blocked by 6-TG. The purine nucleoside inosine had effects opposite to those of 6-TG. Inosine stimulated outgrowth and the characteristic pattern of molecular changes in RGCs and competitively reversed the inhibitory effects of 6-TG. We conclude that axon regeneration and the underlying program of gene expression in goldfish RGCs are mediated via a common, purine-sensitive pathway.  (+info)

*  CD6
... and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213-20. doi: ... domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of ... "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule ... a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137-43. PMID 2016320. Tsuge I, Utsumi KR, Ueda R, Takamoto S, ...
*  ALCAM
... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... 2003). "Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166)". J ... "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule". Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, ...
*  MMP2
A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2. Mutations in the MMP2 gene ... allowing them to bind with cell receptors and influence cell signaling. Furthermore, many MMPs also activate other proMMPs ... Massagué J (July 2008). "TGFbeta in Cancer". Cell. 134 (2): 215-30. doi:10.1016/j.cell.2008.07.001. PMC 3512574 . PMID 18662538 ... "Human endometrial epithelial cells modulate the activation of gelatinase a by stromal cells". Gynecol. Obstet. Invest. 53 (2): ...
*  Degradomics
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by ... These bioactive molecules play roles in coagulation, complement activation, DNA replication, cell-cycle control, cellular ... Placing a reactive group and a recognizable tag feature on the same molecule using a linker moiety gives an ABP molecule its ... Cell Proteomics 3(6):565-76 (2004). Bredemeyer A.J., Lewis R.M., Malone J.P., Davis A.E., Gross J., Townsend R.R., Ley T.J. A ...
*  Pathophysiology of multiple sclerosis
... one of these adhesion proteins involved is ALCAM (Activated Leukocyte Cell Adhesion Molecule, also called CD166), and is under ... Apart from that, activated T-Cells can cross a healthy BBB when they express adhesion proteins. (Adhesion molecules could also ... because activated T-Cells can cross a healthy BBB when they express adhesion proteins. ... April 2000). "Adhesion molecules in multiple sclerosis: relation to subtypes of disease and methylprednisolone therapy". Arch. ...
*  List of MeSH codes (D12.776.395)
... cell adhesion molecules, neuron-glia MeSH D12.776.395.550.200.250.150.050 -- activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.395.550.200.250.520.156 -- antigens, cd56 MeSH D12.776.395.550.200.250.520.578 -- ... vascular cell adhesion molecule-1 MeSH D12.776.395.550.550.500 -- lysosomal-associated membrane protein 1 MeSH D12.776.395.550. ... neural cell adhesion molecule l1 MeSH D12.776.395.550.200.275 -- integrin alphaxbeta2 MeSH D12.776.395.550.200.450 -- ...
*  List of MeSH codes (D23)
... cell adhesion molecules, neuron-glia MeSH D23.050.301.350.250.150.050 --- activated-leukocyte cell adhesion molecule MeSH ... activated-leukocyte cell adhesion molecule MeSH D23.050.301.264.035.101 --- antigens, cd1 MeSH D23.050.301.264.035.102 --- ... activated-leukocyte cell adhesion molecule MeSH D23.101.100.110.101 --- antigens, cd1 MeSH D23.101.100.110.102 --- antigens, ... cell adhesion molecules MeSH D23.050.301.350.065 --- antigens, cd22 MeSH D23.050.301.350.098 --- antigens, cd24 MeSH D23.050. ...
*  List of MeSH codes (D12.776.543)
... cell adhesion molecules, neuron-glia MeSH D12.776.543.550.200.250.150.050 -- activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.543.550.200.250.520.156 -- antigens, cd56 MeSH D12.776.543.550.200.250.520.578 -- ... vascular cell adhesion molecule-1 MeSH D12.776.543.550.425.150 -- calcium channels MeSH D12.776.543.550.425.150.400 -- calcium ... neural cell adhesion molecule l1 MeSH D12.776.543.550.200.275 -- integrin alphaxbeta2 MeSH D12.776.543.550.200.450 -- ...
*  E-selectin
... or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells ... "E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro". Immunology. 77 (4 ... In endothelial cells, various cell-adhesion molecules including E-selectin, are shown to be upregulated upon exposure to ... Adhesion of colon cancer cells to endothelial cells expressing E-selectin induces a reverse signaling in the cancer cells that ...
*  VLA-4
Vascular cell adhesion molecule-1 (VCAM-1 - an integrin receptor) located on an endothelial cell, binds to the integrin VLA-4 ... but they do not adhere to their appropriate ligands until the leukocytes are activated by chemotactic agents or other stimuli ( ... T-cells gain access to the brain by allowing the cells to penetrate the blood brain barrier that normally restricts immune cell ... One approach to prevent an autoimmune reaction has been to block the action of VLA-4 so that self-reactive T-cells are unable ...
*  KLF2
... genes that encode endothelial cell adhesion molecules, causing decreased lymphocyte and leukocyte activation and hence ... T-cells are activated and more prone to apoptosis without KLF2, suggesting that KLF2 regulates T-cell quiescence and survival. ... This activates mechanosensitive channels, which in turn activates two pathways; the MEK5/ERK5 pathway, which activates MEF2, a ... but it is also expressed temporally during embryogenesis in erythroid cells, endothelium, lymphoid cells, the spleen, and white ...
*  Protein C
APC affects endothelial cells by inhibiting inflammatory mediator release and down-regulating vascular adhesion molecules. This ... Activated leukocytes release these inflammatory mediators during inflammation, inhibiting the creation of both thrombomodulin ... "Product Information: Human Activated Protein C - Bovine Activated Protein C - Mouse Activated Protein C". Haematologic ... and it is these cells and leukocytes (white blood cells) that APC affects. Because of the crucial role that protein C plays as ...
*  SGEF
... cells SGEF was recruited to the intracellular domain of the transmembrane adhesion molecule ICAM-1 upon leukocyte adhesion to ... that function to activate small G proteins. In their resting state G proteins are bound to guanosine diphosphate (GDP) and ... SGEF is also expressed in endothelial cells of the vasculature. Several widely used cell lines express this protein, these ... Cell. 15 (7): 3309-19. doi:10.1091/mbc.E04-02-0146. PMC 452585 . PMID 15133129. Samson et al 2013 "The Guanine-Nucleotide ...
*  CEACAM6
2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes ... Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. ... Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c ( ... 1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the ...
*  ICAM-1
... intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells ... ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells ... Frijns CJ, Kappelle LJ (Aug 2002). "Inflammatory cell adhesion molecules in ischemic cerebrovascular disease". Stroke: A ... With the roles of ICAM-1 in cell-cell adhesion, extravasation, and infection more fully understood, a potential role for ICAM-1 ...
*  Leukocyte extravasation
β2 integrins on rolling leukocytes bind endothelial cellular adhesion molecules, arresting cell movement. LFA-1 is found on ... Activated endothelial cells initially express P-selectin molecules, but within two hours after activation E-selectin expression ... white blood cells). The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to ... These findings establish a biological function for catch bonds as a mechanism for flow-enhanced cell adhesion. While leukocytes ...
*  Chemokine receptor
... and changes in the avidity of cell adhesion molecules called integrins. Chemokines and their receptors play a crucial role in ... The subunit called Gβ activates an enzyme known as Phospholipase C (PLC) that is associated with the cell membrane. PLC cleaves ... This role of chemokine is strikingly similar to their normal function of localizing leukocytes to an inflammatory site. Human ... This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location ...
*  Contrast-enhanced ultrasound
... and leukocytes: The inflamed blood vessels specifically express certain receptors, functioning as cell adhesion molecules, like ... Thrombosis and thrombolysis: Activated platelets are major components of blood clots (thrombi). Microbubbles can be conjugated ... Leukocytes possess high adhesion efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system. One ligand: ... and biomimcry of the leukocyte's selectin-integrin cell arrest system, having shown an increased adhesion efficiency, but yet ...
*  Versican
... and their presentation to specific cell-surface receptors. The binding of versican with leukocyte adhesion molecules L-selectin ... "Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis". Nature. 457 (7225): 102-6. doi:10.1038 ... large family of cell adhesion molecules) with their cell surface receptors is sterically hindered. Expression of versican is ... Different tenascin domains interact with a wide range of cellular receptors, including integrins, cell adhesion molecules and ...
*  Sulfatide
Selectins are adhesion molecules that facilitate the capture of circulating leukocytes. Sulfatide is also expressed on the ... Type 2 Natural killer T cells are able to recognize sulfatide/ CD1d tetramers, and as a result, they are activated by different ... macrophages dendritic cells Hepatocytes B cells tumor cells thymocytes Each of these different cell types are expressed in ... There are two types of cell subtypes that interact with CD1d cells: Type 1 Natural killer T cells and Type 2 Natural killer T ...
*  Superantigen
... cells as well as inducing the production of costimulatory molecules that allow the cell to bind to and activate T cells more ... leading to increased expression of adhesion molecules that recruit leukocytes to infected regions. This causes inflammation in ... and can activate up to 100% of T cells). The large number of activated T-cells generates a massive immune response which is not ... of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells. Furthermore, Anti- ...
*  High endothelial venules
Naïve T cells express CCR7 receptor and adhesion molecules L-selectin and LFA-1. As naïve T cells move through the circulation ... In order for an adaptive immune response to occur T cells need to be activated. T cells become activated by recognising foreign ... consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for ... HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor ...
*  Selectin
The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are ... The rolling cancer cells then become activated by locally released chemokines present at the surface of endothelial cells. This ... action attributed to leukocytes during the leukocyte adhesion cascade. Each selectin has a carbohydrate recognition domain that ... On the other hand, several studies further show that cancer cells may initiate the expression of endothelial adhesion molecules ...
*  Complement component 5a
White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. ... C5a is an anaphylatoxin, causing increased expression of adhesion molecules on endothelium, contraction of smooth muscle, and ... C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the ... Both C5a and C5a des-Arg can trigger mast cell degranulation, releasing proinflammatory molecules histamine and TNF-α. C5a is ...
*  CD146
... between Protease-activated Receptor 1 and Platelet-activating Factor Receptor Regulates Melanoma Cell Adhesion Molecule (MCAM/ ... Since these characteristics are important in leukocyte extravasation, MCAM-1 may be an important part of the inflammatory ... also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule ... Guezguez B, Vigneron P, Lamerant N, Kieda C, Jaffredo T, Dunon D (November 2007). "Dual role of melanoma cell adhesion molecule ...
*  CD34
... is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node ... Leucocyte typing 111: White cell differentiation antigens. Oxford University Press, 654-655. Loken M. Shah V. Civin CI.. (1987 ... "Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells". The Journal of Biological ... in a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells ...
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ABIN888844 from antibodies...  anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ABIN888844 from antibodies...
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ABIN888844 from antibodies- ... anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) from antibodies-online. ... Itemanti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ... anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ...
more infohttps://www.biocompare.com/9776-Antibodies/4075002-anti-Activated-Leukocyte-Cell-Adhesion-Molecule-ALCAM-antibody-Alexa-Fluor-488/
ALCAM elisa kit | Cavy Activated Leukocyte Cell Adhesion Molecule ELISA Kit-AAB59499.1  ALCAM elisa kit | Cavy Activated Leukocyte Cell Adhesion Molecule ELISA Kit-AAB59499.1
Cavy Activated Leukocyte Cell Adhesion Molecule ELISA Kit-AAB59499.1 (MBS046317) product datasheet at MyBioSource, ELISA Kits ... Activated Leukocyte Cell Adhesion Molecule (ALCAM), ELISA Kit. Also Known As Cavy Activated Leukocyte Cell Adhesion Molecule ... Cell Adhesion Molecules (CAMs) Pathway Diagram. Cell Adhesion Molecules (CAMs) Pathway antibodies. Cell Adhesion Molecules ( ... This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), ...
more infohttps://www.mybiosource.com/prods/ELISA-Kit/Cavy/Activated-Leukocyte-Cell-Adhesion-Molecule/ALCAM/datasheet.php?products_id=46317
Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]  -ORCA  Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract] -ORCA
Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]. Wound Repair ... Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract] ... Our purpose was assess the impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM) on Human Vascular Endothelial Cells ( ... the following cell sublines were created; a control (HECVpEF) endothelial cell line and a ALCAM-knockdown (HECVALCAM/KD) cell ...
more infohttp://orca-mwe.cf.ac.uk/18941/
anti-CD166 antibody, N-term  | GeneTex  anti-CD166 antibody, N-term | GeneTex
... activated leukocyte cell adhesion molecule) for FACS, IHC-P, WB. Anti-CD166 pAb (GTX81961) is tested in Human samples. 100% Ab- ... activated leukocyte cell adhesion molecule. Background. Cell adhesion molecule that binds to CD6. Involved in neurite extension ... May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the ... Cancer Cell Biology Disease Related Epigenetics Epitope Tags Immunology Infectious Disease Metabolism Neuroscience Signal ...
more infohttp://www.genetex.com/CD166-antibody-N-term-GTX81961.html
anti-CD166 antibody [8E12C7]  | GeneTex  anti-CD166 antibody [8E12C7] | GeneTex
... activated leukocyte cell adhesion molecule) for ELISA, FACS, ICC/IF, IHC-P, WB. Anti-CD166 mAb (GTX60782) is tested in Human ... activated leukocyte cell adhesion molecule. Background. This gene encodes activated leukocyte cell adhesion molecule (ALCAM), ... This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. ... Cancer Cell Biology Disease Related Epigenetics Epitope Tags Immunology Infectious Disease Metabolism Neuroscience Signal ...
more infohttp://www.genetex.com/ALCAM-antibody-8E12C7-GTX60782.html
OriGene - ALCAM (NM 001627) cDNA Clone  OriGene - ALCAM (NM 001627) cDNA Clone
Human activated leukocyte cell adhesion molecule (ALCAM) available for purchase from OriGene - Your Gene Company. ... Mouse activated leukocyte cell adhesion molecule (Alcam). $720. Next day. MG209127. Alcam (GFP-tagged) - Mouse activated ... ALCAM (untagged)-Human activated leukocyte cell adhesion molecule (ALCAM), NM_001627.2, 10ug. $700. In Stock. ... Lenti ORF clone of Alcam (mGFP-tagged ORF) - Rat activated leukocyte cell adhesion molecule (Alcam), (10 ug). $990. 7 weeks. ...
more infohttp://www.origene.com/human_cdna/NM_001627/SC316550.aspx
CD6 - Wikipedia  CD6 - Wikipedia
... and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213-20. doi: ... domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of ... "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule ... a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137-43. PMID 2016320. Tsuge I, Utsumi KR, Ueda R, Takamoto S, ...
more infohttps://en.wikipedia.org/wiki/CD6
The Egyptian Journal of Haematology : Table of Contents  The Egyptian Journal of Haematology : Table of Contents
Endothelial adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E- ... Endothelial activation markers and activated leukocytes are significantly increased in β-thalassemics, showing that a severe ... B-cell activating factor (BAFF) plays a crucial role in B-cell development, survival, and immunoglobulin production. Excess ... Expression of B-cell activating factor and its receptor in idiopathic thrombocytopenic purpura. p. 166. ...
more infohttp://www.ehj.eg.net/showBackIssue.asp?issn=1110-1067
ALCAM (Activated Leukocyte Cell Adhesion Molecule)  ALCAM (Activated Leukocyte Cell Adhesion Molecule)
Activated Leukocyte Cell Adhesion Molecule), Authors: Esra Yavuz, Merve Oyken, Ayse Elif Erson Bensan. Published in: Atlas ... of plasma membrane focal adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ... of plasma membrane focal adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ... Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell ...
more infohttp://atlasgeneticsoncology.org/Genes/GC_ALCAM.html
Activated-Leukocyte Cell Adhesion Molecule | Profiles RNS  Activated-Leukocyte Cell Adhesion Molecule | Profiles RNS
Activated-Leukocyte Cell Adhesion Molecule*Activated-Leukocyte Cell Adhesion Molecule. *Activated Leukocyte Cell Adhesion ... "Activated-Leukocyte Cell Adhesion Molecule" by people in this website by year, and whether "Activated-Leukocyte Cell Adhesion ... Cell Adhesion Molecules, Neuron-Glia [D23.050.301.350.250.150]. *Activated-Leukocyte Cell Adhesion Molecule [D23.050.301.350. ... Cell Adhesion Molecules, Neuron-Glia [D12.776.395.550.200.250.150]. *Activated-Leukocyte Cell Adhesion Molecule [D12.776. ...
more infohttps://profiles.umassmed.edu/display/117417
ALCAM (activated leukocyte cell adhesion molecule) - KOMP (Knockout Mouse Project)  ALCAM (activated leukocyte cell adhesion molecule) - KOMP (Knockout Mouse Project)
OMIM: ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALCAM*Gene Ontology: Alcam *Mouse Phenome DB: Alcam *UCSC: Chr.16:52,248,996- ... activated leukocyte cell adhesion molecule. Synonyms: BEN, CD166, DM-GRASP, MuSC, SC1. Gene nomenclature, locus information, ... Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International ...
more infohttps://www.komp.org/geneinfo.php?geneid=23020
Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis  - Zurich Open...  Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis - Zurich Open...
Activated leukocyte cell adhesion molecule (ALCAM) is expressed on various cell types, including leukocytes, endothelial cells ... Activated leukocyte cell adhesion molecule (ALCAM) is expressed on various cell types, including leukocytes, endothelial cells ... Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis ZORA Maintenance. ... Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis. American Journal of ...
more infohttps://www.zora.uzh.ch/id/eprint/143584/
Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by...  Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by...
Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ...
more infohttps://mcb.asm.org/content/26/13/5086/figures-only
ALCAM clia kit | Human Activated Leukocyte Cell Adhesion Molecule (ALCAM) CLIA Kit-AAI37097.1  ALCAM clia kit | Human Activated Leukocyte Cell Adhesion Molecule (ALCAM) CLIA Kit-AAI37097.1
Human Activated Leukocyte Cell Adhesion Molecule (ALCAM) CLIA Kit-AAI37097.1 (MBS2025416) product datasheet at MyBioSource, ... Activated Leukocyte Cell Adhesion Molecule (ALCAM), CLIA Kit. Also Known As Activated Leukocyte Cell Adhesion Molecule (ALCAM) ... Cell Adhesion Molecules (CAMs) Pathway Diagram. Cell Adhesion Molecules (CAMs) Pathway antibodies. Cell Adhesion Molecules ( ... This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), ...
more infohttps://www.mybiosource.com/prods/CLIA-Kit/Activated-Leukocyte-Cell-Adhesion-Molecule-ALCAM/ALCAM/datasheet.php?products_id=2025416&cacheID=5396562052ab9701b804e4ed9c5a9b90&att=976
Lirias: Activated Leukocyte Cell Adhesion Molecule/CD166, a marker of tumor progression in primary malignant melanoma of the...  Lirias: Activated Leukocyte Cell Adhesion Molecule/CD166, a marker of tumor progression in primary malignant melanoma of the...
Activated Leukocyte Cell Adhesion Molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin. ... Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity ... You are here: Lirias › KU Leuven › Biomedical Sciences Group › Department of Imaging & Pathology › Translational Cell & Tissue ... of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions ...
more infohttps://lirias.kuleuven.be/handle/123456789/271522
Mesenchymal Stem Cell Surface Antigen SB-10 Corresponds to Activated Leukocyte Cell Adhesion Molecule and Is Involved in...  Mesenchymal Stem Cell Surface Antigen SB-10 Corresponds to Activated Leukocyte Cell Adhesion Molecule and Is Involved in...
Mesenchymal Stem Cell Surface Antigen SB-10 Corresponds to Activated Leukocyte Cell Adhesion Molecule and Is Involved in ... we report on the immunopurification of the SB-10 antigen and its identification as activated leukocyte-cell adhesion molecule ( ... thereby implicating a role for ALCAM during bone morphogenesis and adding ALCAM to the group of cell adhesion molecules ... The cell surface antigen recognized by monoclonal antibody SB-10 is expressed on human MSCs but is lost during their ...
more infohttps://insights.ovid.com/jbomr/199804000/00000105-199804000-00013
Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA Kit Manufacturers in Delhi  Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA Kit Manufacturers in Delhi
Activated Leukocyte Cell Adhesion Molecule) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA Kit » Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA ... Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA Kit. Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA ... Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA Kit. Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA ...
more infohttps://www.odspl.com/sub-product/Rat+ALCAM+%28Activated+Leukocyte+Cell+Adhesion+Molecule%29+ELISA+Kit.php
YUHSpace: Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy  YUHSpace: Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy
... regulates T cell responses in a murine model of food allergy, doi: 10.1111/cei.13104, category: Article ... Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy ... ALCAM ; CD166 ; activated leucocyte cell adhesion molecule ; food allergy. Abstract. Food allergy is a major public health ... Studies have shown that long-term interactions between activated leucocyte cell adhesion molecule (ALCAM/CD166) on the surface ...
more infohttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162316
Cocaine hijacks δ1 receptor to initiate induction of activated leukocyte cell adhesion molecule: Implication for increased...  Cocaine hijacks δ1 receptor to initiate induction of activated leukocyte cell adhesion molecule: Implication for increased...
... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ...
more infohttps://nebraska.pure.elsevier.com/en/publications/cocaine-hijacks-%CE%B41-receptor-to-initiate-induction-of-activated-le
  • Decrease in intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) expression promotes tumor cell spreading in vivo. (cancerprev.org)
  • As a result of these binding characteristics, ICAM-1 has classically been assigned the function of intercellular adhesion. (wikipedia.org)
  • abstract = "Human immunodeficiency virus (HIV)-associated increase in monocyte adhesion and trafficking is exacerbated by cocaine abuse. (elsevier.com)
  • Spots in red represent proteins with a greater-than-1.5-fold decrease in the conditioned medium of cells treated with BB94. (asm.org)
  • Genetic variants variants in SGEF have been associated with coronary artery disease SGEF is part of a large class of proteins (GEFs) that function to activate small G proteins. (wikipedia.org)
  • GEFs activate G proteins by promoting nucleotide exchange. (wikipedia.org)
  • Crystal structures of the enterotoxins reveals that they are compact, ellipsoidal proteins sharing a characteristic two-domain folding pattern comprising an NH2-terminal β barrel globular domain known as the oligosaccharide / oligonucleotide fold, a long α-helix that diagonally spans the center of the molecule, and a COOH terminal globular domain. (wikipedia.org)
  • In the case of Lewis lung carcinoma (LLC), an additional defect in tumor cell homing to the lungs and a resulting reduction in the number of lung tumor nodules were observed. (uzh.ch)
  • Therefore, T cells need a region where they can go to sample foreign antigens that have entered the body. (wikipedia.org)
  • Naïve T cells in the circulation regularly move through the lymph nodes via HEV in order to scan the APC for foreign antigens. (wikipedia.org)
  • Superantigens (SAgs) are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. (wikipedia.org)
  • The large number of activated T-cells generates a massive immune response which is not specific to any particular epitope on the SAg thus undermining one of the fundamental strengths of the adaptive immune system, that is, its ability to target antigens with high specificity. (wikipedia.org)
  • Resistin itself can be upregulated by interleukins and also by microbial antigens such as lipopolysaccharide, which are recognized by leukocytes. (wikipedia.org)
  • B cells can present antigens to a specialized group of helper T cells called TFH cells. (wikipedia.org)
  • Lysates from the indicated cells were analyzed by Western blotting with polyclonal antibodies against the cytoplasmic domain of ADAM17. (asm.org)
  • Cells were washed, lysed, and cell lysates (L) analyzed by Western blotting with antibodies against the extracellular domains of TfnR, ALCAM, and Dsg-2 as indicated. (asm.org)
  • A. Wild-type CHO cells (WT) or M2 mutant cells were lysed and cell lysates analyzed by Western blotting with antibodies against ADAM17 or ADAM10 as indicated. (asm.org)
  • B. Lysates (L) from wild-type CHO cells or M2 cell mutants and medium samples (M) obtained after 48 h of serum starvation were concentrated by WGA-agarose chromatography and analyzed by Western blotting with antibodies against the extracellular domain of ALCAM. (asm.org)
  • Furthermore, Anti-CD3 and Anti-CD28 Antibodies (CD28-SuperMAB) have also shown to be highly potent superantigens (and can activate up to 100% of T cells). (wikipedia.org)
  • The end-result is a B cell that is able to mass-produce specific antibodies against an antigenic target. (wikipedia.org)
  • Novel view on the mechanism of activation of matrix metalloproteinase (mmp): binding of mmp-9 (gelatinase b) to extracellular matrix molecules in vivo and in vitro leads to activation od the enzyme without removal of its n-terminal propeptide. (cancerprev.org)
  • Sulfatide is primarily found on the extracellular leaflet of the myelin plasma membrane produced by the oligodendrocytes in the central nervous system and in the Schwann cells in the peripheral nervous system. (wikipedia.org)
  • However, sulfatide is also present on the extracellular leaflet of the plasma membrane of many cells in eukaryotic organisms. (wikipedia.org)
  • When megakaryocytes and endothelial cells are activated by agonists such as thrombin, P-selectin is rapidly translocated to the plasma membrane from granules. (wikipedia.org)
  • VAP-1 is primarily localized on the cell surface on the adipocyte plasma membrane. (wikipedia.org)
  • In particular, hydrogen peroxide, released during the deamination of SSAO, acts as a signal-transducing molecule, affecting GLUT1 and GLUT4 translocation to the plasma membrane by granulosa cells and adipose tissue. (wikipedia.org)
  • A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the extracellular milieu to the cell surface. (wikipedia.org)
  • Different from P-selectin, which is stored in vesicles called Weibel-Palade bodies, E-selectin is not stored in the cell and has to be transcribed, translated, and transported to the cell surface. (wikipedia.org)
  • Phytoestrogens, plant compounds with estrogen-like biological activity, such as genistein, formononetin, biochanin A and daidzein, as well as a mixture of these phytoestrogens were found able to reduce E-selectin as well as VCAM-1 and ICAM-1 on cell surface and in culture supernatant. (wikipedia.org)
  • This causes the leukocytes to slow down and begin rolling along the inner surface of the vessel wall. (wikipedia.org)
  • The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to roll along the endothelial surface. (wikipedia.org)
  • On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. (wikipedia.org)
  • Beyond its classically described functions as an adhesion and viral entry molecule, ICAM-1 has now been characterized convincingly as possessing a role in signal transduction. (wikipedia.org)
  • The underlying mechanisms involve cocaine-mediated up regulation of adhesion molecules with subsequent disruption of the blood- brain barrier (BBB). (elsevier.com)
  • First, P-selectin is synthesized by megakaryocytes and endothelial cells, where it is sorted into the membranes of secretory granules. (wikipedia.org)