Cell adhesion molecule expressed on activated leukocytes, fibroblasts, and neurons. It is a ligand for CD6. ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes.
Proteins that are preferentially expressed or upregulated during FETAL DEVELOPMENT.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).
Adherence of cells to surfaces or to other cells.
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.
Assays that measure the rate of migration of LEUKOCYTES. They may involve a variety of techniques such as measuring the movement of leukocytes through substrates such as AGAROSE gels or the rate of exit of cells from a glass capillary.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Tumors or cancer of the UTERINE CERVIX.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).
A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2 that can transform normal T-lymphocytes and can replicate in both T- and B-cell lines. The virus is related to but distinct from HTLV-1.
A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2, closely related to the human HTLV-1 virus. The clinical, hematological, and histopathological characteristics of the disease in STLV-infected monkeys are very similar to those of human adult T-cell leukemia. Subgroups include the African green monkey subtype (STLV-I-AGM), for which the nucleotide sequence is 95% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1, and the Asian rhesus macaque subtype (STLV-I-MM), for which the nucleotide sequence is 90% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1.
The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.
Tumors or cancer of the human BREAST.
A cell line derived from cultured tumor cells.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Distribution and function of the adhesion molecule BEN during rat development. (1/109)

It is well established that the notochord influences the development of adjacent neural and mesodermal tissue. Involvement of the notochord in the differentiation of the dorsal pancreas has been demonstrated. However, our knowledge of the signals involved in pancreatic development is still incomplete. In order to identify proteins potentially implicated during pancreatic differentiation, we raised and characterized monoclonal antibodies against previously established embryonic pancreatic ductal epithelial cell lines (BUD and RED). Using the MAb 2117, the cell surface antigen 2117 (Ag 2117) was cloned. The predicted sequence for Ag 2117 is the rat homologue of BEN. Initially reported as a protein expressed on epithelial cells of the chicken bursa of Fabricius, BEN is expressed in a variety of tissues during development and described as a marker for the developing central and peripheral chicken nervous systems. A role has been suggested for BEN in the adhesion of stem cells and progenitor cells to the blood-forming tissue microenvironment. In this study, we demonstrate that BEN, initially expressed exclusively in the notochord during the early development of rat, is implicated in pancreatic development. We show that Ag 2117 regulates the pancreatic epithelial cell growth through the ras and Jun kinase pathways. In addition, we demonstrate that Ag 2117 is able to regulate the expression of the transcription factor PDX1, required for insulin gene expression, in embryonic pancreas organ cultures.  (+info)

Extracellular matrix-associated protein Sc1 is not essential for mouse development. (2/109)

Sc1 is an extracellular matrix-associated protein whose function is unknown. During early embryonic development, Sc1 is widely expressed, and from embryonic day 12 (E12), Sc1 is expressed primarily in the developing nervous system. This switch in Sc1 expression at E12 suggests an importance for nervous-system development. To gain insight into Sc1 function, we used gene targeting to inactivate mouse Sc1. The Sc1-null mice showed no obvious deficits in any organs. These mice were born at the expected ratios, were fertile, and had no obvious histological abnormalities, and their long-term survival did not differ from littermate controls. Therefore, the function of Sc1 during development is not critical or, in its absence, is subserved by another protein.  (+info)

Evidence for the expression of a second CD6 ligand by synovial fibroblasts. (3/109)

OBJECTIVE: CD6, a cell surface glycoprotein expressed primarily on T cells, may function as a costimulatory molecule and may play a role in autoreactive immune responses. Recently, a CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule [ALCAM]) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. However, the results of functional studies have suggested the existence of a second CD6 ligand. The present study was undertaken to seek evidence for a second CD6 ligand on cultured synovial fibroblasts. METHODS: Flow cytometric and biochemical techniques were applied, using anti-CD166 monoclonal antibody (mAb) and a recombinant CD6 fusion protein, to determine whether cultured synovial fibroblasts and other cell types expressed a non-ALCAM CD6 ligand. RESULTS: CD14- fibroblastic synoviocytes showed greater binding of a recombinant CD6 fusion protein than of anti-ALCAM mAb. With interferon-gamma treatment of synovial fibroblasts, binding of both reagents increased, but this was more marked for binding of CD6 fusion protein. Exposure of synovial fibroblasts to other cytokines or to the superantigen staphylococcal enterotoxin A also regulated binding of CD6 fusion protein and anti-ALCAM mAb in a discordant manner. Immunoprecipitation of proteins from membrane extracts of synovial fibroblasts with a CD6-Ig fusion protein revealed a novel 130-kd band distinct from CD166; an identical molecule was also precipitated from membranes of HBL-100 tumor cells. CONCLUSION: Taken together with previous data regarding CD6 and CD166 function, the present findings strongly suggest the existence of a second CD6 ligand distinct from CD166, which can be expressed by synovial fibroblasts as well as other cells.  (+info)

Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin. (4/109)

Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions reveals that ALCAM expression correlates with melanoma progression. Most nevi (34/38) and all thin melanomas studied (Clark levels I and II) did not express ALCAM. In contrast, immunoreactivity was detected in the invasive, vertical growth phase of 2 of the 13 Clark level III lesions tested. The fraction of positive lesions further increased in Clark level IV (13/19) and in Clark level V (4/4) lesions. ALCAM expression was exclusively detectable in the vertical growth phase of the primary tumor. In melanoma metastases, approximately half of the lesions tested (13/28) were ALCAM positive. According to the Breslow-thickness, ALCAM expression was observed in less than 10% of the lesions that were thinner than 1.5 mm and in over 70% of the lesions that were thicker than 1.5 mm. Our results strongly suggest that ALCAM plays an important role in melanocytic tumor progression and depict it as a new molecular marker for neoplastic progression of primary human melanoma.  (+info)

DM-GRASP is necessary for nonradial cell migration during chick diencephalic development. (5/109)

Cell migration is fundamental to normal CNS development. Radial migration, along radial glial fibers, has been the principal pathway studied, however, nonradial or tangential cell migration has increasingly been identified at all levels of the CNS. Receptors, cell adhesion molecules, and extracellular matrix molecules have all been shown to participate in radial cell migration. In contrast, the molecular basis of nonradial cell migration has only recently begun to be elucidated. Using replication defective retroviral vectors we have determined the location and time when nonradial cell migration begins in the developing chick diencephalon. We have identified three molecules that are expressed in spatially and temporally restricted domains that are consistent with them playing a role in nonradial cell migration. One of these molecules, DM-GRASP, a transmembrane protein with five extracellular Ig domains, is expressed on the nonradially migrating cells in addition to axons. To test the hypothesis that DM-GRASP participates in guiding nonradial cell migration, we injected a replication-defective retroviral vector used for lineage tracing followed by a DM-GRASP blocking antibody. Embryos injected with the blocking antibody showed a near complete block in nonradial cell migration specifically where DM-GRASP is expressed. Furthermore, morphological analyses revealed disruption of the normal architecture of the diencephalon indicating nonradial cell migration is necessary for normal morphological development of the brain. Our data indicate that DM-GRASP is necessary for nonradial cell migration in the chick diencephalon and have provided a system to further explore the function of nonradial cell migration during CNS development.  (+info)

Dynamic regulation of activated leukocyte cell adhesion molecule-mediated homotypic cell adhesion through the actin cytoskeleton. (6/109)

Restricted expression of activated leukocyte cell adhesion molecule (ALCAM) by hematopoietic cells suggests an important role in the immune system and hematopoiesis. To get insight into the mechanisms that control ALCAM-mediated adhesion we have investigated homotypic ALCAM-ALCAM interactions. Here, we demonstrate that the cytoskeleton regulates ALCAM-mediated cell adhesion because inhibition of actin polymerization by cytochalasin D (CytD) strongly induces homotypic ALCAM-ALCAM interactions. This induction of cell adhesion is likely due to clustering of ALCAM at the cell surface, which is observed after CytD treatment. Single-particle tracking demonstrated that the lateral mobility of ALCAM in the cell membrane is increased 30-fold after CytD treatment. In contrast, both surface distribution and adhesion of a glycosylphosphatidylinositol (GPI)-anchored ALCAM mutant are insensitive to CytD, despite the increase in lateral mobility of GPI-ALCAM upon CytD treatment. This demonstrates that clustering of ALCAM is essential for cell adhesion, whereas enhanced diffusion of ALCAM alone is not sufficient for cluster formation. In addition, upon ligand binding, both free diffusion and the freely dragged distance of wild-type ALCAM, but not of GPI-ALCAM, are reduced over time, suggesting strengthening of the cytoskeleton linkage. From these findings we conclude that activation of ALCAM-mediated adhesion is dynamically regulated through actin cytoskeleton-dependent clustering.  (+info)

Expression of DM-GRASP/BEN in the developing mouse spinal cord and various epithelia. (7/109)

The expression pattern of the immunoglobulin DM-GRASP/BEN gene was studied in the mouse embryo using in situ hybridization. DM-GRASP/BEN is expressed in the spinal cord in a subset of motoneurons expressing Islet-1, and non homogeneously in the dorsal root ganglia (DRG). In contrast, it's expression is homogeneous in the vestibulo-cochlear and trigemminal ganglia. DM-GRASP/BEN is also expressed in various epithelia of ectodermal or endodermal origin like the nasal, buccopharyngal and lung epithelia. In upper lip, DM-GRASP/BEN transcripts are present in the epidermal cells of the developing hair vibrissa follicles. First detected in the hair placode, DM-GRASP/BEN expression is localized in the central cells of the epithelial hair peg and then in a thin layer of cells crushed against the outer root sheath by the outgrowth of the hair shaft.  (+info)

A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells. (8/109)

In lower vertebrates, retinal ganglion cells (RGCs) can regenerate their axons and reestablish functional connections after optic nerve injury. We show here that in goldfish RGCs, the effects of several trophic factors converge on a purine-sensitive signaling mechanism that controls axonal outgrowth and the expression of multiple growth-associated proteins. In culture, goldfish RGCs regenerate their axons in response to two molecules secreted by optic nerve glia, axogenesis factor-1 (AF-1) and AF-2, along with ciliary neurotrophic factor. The purine analog 6-thioguanine (6-TG) blocked outgrowth induced by each of these factors. Previous studies in PC12 cells have shown that the effects of 6-TG on neurite outgrowth may be mediated via inhibition of a 47 kDa protein kinase. Growth factor-induced axogenesis in RGCs was accompanied by many of the molecular changes that characterize regenerative growth in vivo, e.g. , increased expression of GAP-43 and certain cell surface glycoproteins. 6-TG inhibited all of these changes but not those associated with axotomy per se, e.g., induction of jun family transcription factors, nor did it affect cell survival. Additional studies using RGCs from transgenic zebrafish showed that expression of Talpha-1 tubulin is likewise stimulated by AF-1 and blocked by 6-TG. The purine nucleoside inosine had effects opposite to those of 6-TG. Inosine stimulated outgrowth and the characteristic pattern of molecular changes in RGCs and competitively reversed the inhibitory effects of 6-TG. We conclude that axon regeneration and the underlying program of gene expression in goldfish RGCs are mediated via a common, purine-sensitive pathway.  (+info)

An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in various cancer types. In some cancers ALCAM has a prognostic value or is predictive for the benefit of therapeutic interventions. To date there are no data on the role of ALCAM in cervical cancer available. In this study, ALCAM expression was analysed by immunohistochemistry (IHC) in tissue samples of 233 patients with cervical cancer, among them 178 with complete follow-up information. In addition, soluble (s-)ALCAM was measured in sera of a subset of the included patients (n = 55) by enzyme-linked immunosorbent assay (ELISA). ALCAM overexpression was detected (immunoreactive score (IRS) 2-12) in 58.4% of the cervical cancer samples. The normal ectocervical or endocervical epithelium showed no ALCAM reactivity. In untreated patients, ALCAM overexpression in tumor tissue tended to be associated with shorter cancer-specific survival (CSS) and disease-free survival (DFS). Patients,
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ABIN888844 from antibodies-online
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Our purpose was assess the impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM) on Human Vascular Endothelial Cells (HECV), these cell are important in angiogenesis and hence wound healing. HECV line positive for ALCAM were used. Anti-ALCAM transgenes were constructed based on the secondary structure of the ALCAM mRAN. After transfection of HECV cells with the transgene and control vectors, the following cell sublines were created; a control (HECVpEF) endothelial cell line and a ALCAM-knockdown (HECVALCAM/KD) cell line. We then assessed the impact of ALCAM on cellular migration of the endothelial cells by way of electric wounding using Electrical Cell Impedence Sensing (ECIS) zy model. We successfully suppressed the expression of ALCAM in HECV cells by using the anti-ALCAM transgene. HECV rapidly migrated after wounding. It recovered at a rapid pace (0.57/min). Interestingly, after losing ALCAM transcript, the HECVALCAM/KD cells migrated at a substantially reduced rate. Finally, the ...
ALCAM/CD166 Rat anti-Mouse, Clone: 200622, R&D Systems™ 100ug; Unlabeled ALCAM/CD166 Rat anti-Mouse, Clone: 200622, R&D Systems™ Primary Antibodies...
ALCAM - ALCAM (untagged)-Human activated leukocyte cell adhesion molecule (ALCAM) available for purchase from OriGene - Your Gene Company.
CD6 antigen is a typeI cell membrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily groupB, predominantly expressed by T cells and a B-cell subset. CD6 binds activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily (IgSF). ALCAM is expressed on activated T cells, B cells, monocytes, skin fibroblasts, keratinocytes and rheumatoid arthritis synovium, and mediates homophilic and heterophilic adhesion. CD6-ligand interaction has been implicated in cell adhesion, T-cell maturation and regulation of activation, constituting an uncommon type of protein-protein superfamilies interaction. The ior t1 is a murine IgG2a mAb recognizing a different epitope compared to other anti-CD6 mAbs. It is in a phase II clinical trial (PIICT) for cutaneous T-cell lymphomas treatment. Recently, we reported its intravenous therapeutic effect in a Psoriasis vulgaris patient. A PIICT was performed in 18 rheumatoid arthritis patients. ...
CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene. This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. Certain alleles of this gene may be associated with susceptibility to multiple sclerosis. Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000013725 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024670 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: CD6 CD6 molecule. Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J. Exp. Med. 181 (6): 2213-20. ...
Several laboratories have begun to characterize the interactions between MSCs and cells of the immune system. hMSCs have a number of surface molecules that would predict interaction with T cells. MHC I, Thy-1 (CD90), vascular cell adhesion molecule (CD106, VCAM), intercellular adhesion molecule 1 (ICAM-1) and ICAM-2, activated leukocyte cell adhesion molecule (CD166, ALCAM), lymphocyte functional antigen-3, and integrins α1 to α3, α5, α6, β1, β3, and β4 (CD49 a, b, c, e, and f) are surface molecules expressed on hMSCs that have cognate ligands on T cells.21,28,50,51 Additionally, although not expressed at appreciable levels on hMSCs, MHC II expression is upregulated by incubating the cells with interferon-γ. However, the hMSCs lack the B7 costimulatory molecules CD80 and CD86, and these are not expressed after interferon treatment.52,53. Intuitively, one might expect allogeneic MSCs (allo-MSCs) would stimulate T cell proliferation and that donor MSCs would be recognized by responder T ...
Clone REA442 recognizes the human CD166 antigen, a single-pass type I membrane protein also known as activated leukocyte cell adhesion molecule (ALCAM). CD166, a member of the immunoglobulin superfamily and a ligand for the lymphocyte antigen CD6, mediates homophilic and heterophilic adhesion. It is expressed on activated leukocytes T cells, B cells, monocytes, hematopoietic stem cells (HSCs), metastasizing melanoma, neuronal cells, endothelial cells, hematopoiesis-supporting osteoblastic cell lines, and mesenchymal stem cells (MSCs). CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human HSCs and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate. Additional information: Clone REA442 displays negligible binding to Fc receptors. - Sverige
CD166 antibody [8E12C7] (activated leukocyte cell adhesion molecule) for ELISA, FACS, ICC/IF, IHC-P, WB. Anti-CD166 mAb (GTX60782) is tested in Human samples. 100% Ab-Assurance.
CD166 antibody, N-term (activated leukocyte cell adhesion molecule) for FACS, IHC-P, WB. Anti-CD166 pAb (GTX81961) is tested in Human samples. 100% Ab-Assurance.
The above results indicate that ALCAM-ALCAM interactions are crucial to the survival and primary site maintenance of breast cancer cells. Impaired expression of ALCAM/CD166 is associated with the induction of two types of programmed cell death, apoptosis and autophagy, in breast cancer cells. This a …
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A and an apparatus method for quickly and easily identifying the five basic components of leukocyte cells: basophils, eosinophils, neutrophils, monocytes and lymphocytes is disclosed. The method measures the size of each of the cells. Computation of the quantile feature of the cells and their color is then made. BA and EO cells are differentiated from LY and MO and Ne cells using the present method. BA and EO cells can also be differentiated from LY, MO, and Ne cells using methods of the prior art. Once BA and EO cells have been differentiated from the five leukocyte cells, LY cells can be differentiated from MO and NE cells based upon the size of the LY cells. The average color intensity of the LY cells determined is then used as the threshold to differentiate MO cells from NE cells.
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP ...
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Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of ...
CD166 (ALCAM), APC, clone: eBioALC48, eBioscience™ 25μg; APC CD166 (ALCAM), APC, clone: eBioALC48, eBioscience™ Primary Antibodies CD151 to CD200
Preclinical DSS IBD Model. Inflammation: IBD, Crohns & Colitis. Pathology involves innate inflammation to study leukocyte cells and more.
CHO-Anti-Human ALCAM F(ab) stable cell line is clonally-derived from a CHO cell line, which has been transfected with an Anti-human ALCAM F(ab) gene to allow expression of the F(ab). It is an example of a cell line transfected using our proprietary CBTGS gene screening and amplification system.
Cell adhesion molecule expressed on activated leukocytes, fibroblasts, and neurons. It is a ligand for CD6. ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes. . ...
Human ALCAM full-length ORF ( AAH57809.1, 1 a.a. - 133 a.a.) recombinant protein with GST-tag at N-terminal. (H00000214-P01) - Products - Abnova
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CD166 (ALCAM) Mouse anti-Human, PerCP-eFluor 710, Clone: 3A6, eBioscience™ 25 tests; PerCP-eFluor 710 CD166 (ALCAM) Mouse anti-Human, PerCP-eFluor 710, Clone:...
TY - JOUR. T1 - Regulation of human LZIP expression by NF-κB and its involvement in monocyte cell migration induced by Lkn-1. AU - Jang, Sung Wuk. AU - Yoon, Suk Kim. AU - Yoon, Rim Kim. AU - Ho, Joong Sung. AU - Ko, Jesang. PY - 2007/4/13. Y1 - 2007/4/13. N2 - Human LZIP is a transcription factor that is involved in leukocyte cell mobility. Expression of LZIP is known to differentially regulate monocyte cell migration induced by CCR1-dependent chemokines. However, its transcriptional regulation has not been characterized. Our results indicate that Lkn-1 induces LZIP expression in a time- and dose-dependent manner, and the induction of LZIP shows an immediate early response to Lkn-1. We identified and cloned ∼1.4 kb of the LZIP promoter from a human genomic DNA. To identify regulatory elements controlling restricted expression of LZIP, deletion mutants were constructed from the 1469-bp LZIP promoter region (-1219/+251) linked to the luciferase reporter gene. Maximal promoter activity was ...
ITGA4 Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB ...
exchanger or the BSC-1 and BSC-2 isoforms of the Na+/K+/2Cl−cotransporter, could also be involved in RTC apoptosis, by impeding intracellular volume expansion. However, prominent functions for these proteins in proximal RTC apoptosis are unlikely, since none are abundantly expressed in the proximal tubule (1,15, 18).. In addition to cell shrinkage, RTC NHE1 degradation was also associated with intracellular acidification (16). The data are in agreement with studies in leukocyte cell lines, which demonstrate that apoptosis is preceded by decreased pHi (16,27, 36). Importantly, NHE1 stimulation prevented intracellular acidification and abrogated apoptosis (16, 36), indicating NHE1 activation opposes apoptosis. Rich et al. (40) demonstrated that human leukemia cells exhibit a significantly higher pHi compared with normal leukocyte lineage cells. Moreover, decreased pHi was associated with increased apoptosis, which was exacerbated by exposure to the NHE1 inhibitor HMA. Barrière et al. (2) ...
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We have identified a 95 kd cell surface protein, DM-GRASP, that is expressed on a restricted population of axons. Its expression begins early in chick embryogenesis, and within the spinal cord it is localized to axons in the dorsal funiculus, midline floorplate cells, and motoneurons. Antibodies to …
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Taylor, Ben I_BEN/0002 -- Discover Life
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A molekuláris genetikai technológiák fejlődése következtében egyre több, korábban idiopátiásnak tartott betegség hátterében ismerjük meg a genetikai eltérést. A generalizált epilepsziában szenvedő, a betegség lefolyása során epilepsziaszindrómát váltó, jó intellektusú, kiterjedt hipopigmentált folttal rendelkező fiúgyermek célzott genetikai vizsgálata neurocutan szindróma irányába nem hozott eredményt. Teljesexom-szekvenálás során egy kálium-klorid-kotranszporter génjének heterozigóta misszensz mutációja igazolódott, ami a fenotípussal összevetve, az irodalomban az idiopátiás generalizált epilepszia 14-es típusaként ismert epilepsziaszindróma diagnózisát támasztja alá. Orv Hetil. 2019; 160(21): 835-838. ...
Hall of Fame running back Jerome Bettis on whether or not Ben Roethlisberger is ready to retire and if Mike Tomlin gets enough credit for the Steelers success.
The doctor who performed a procedure on Ben Roethlisberger's meniscus told the Steelers that the quarterback could miss 4-6 weeks, sources told ESPN.
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The aim of this study was to analyze the leukocytes in the blood using electronic and light microscopy and their seasonal distribution, also to characterize the leukocyte cells replacement and mainly to characterize the mononuclear phagocytes in the blood and their phagocytic capacity. In this study, it was used six turtles (Phrynops hilarii), caught at the Guaíba river estuary, Porto Alegre, Rio Grande do Sul, Brazil and lodged for 1 week at the Central Animal House, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Blood was obtained during the seasonal periods by puncturing the lateral vessels of the neck. The blood samples were stained by Leishmann and Giemsa, counting five hundred cells in each animal. After the obtained data, it was applied the Bonferroni test as statistical method. For the autoradiographic analysis, it was injected in the circulating blood 1000 μCi/kg of 3Hthymidine. For electronic microscopy, it was processed the leukocyte substrate by circulating blood ...
Deoxyribonuclease-1-like 2 is an enzyme that in humans is encoded by the DNASE1L2 gene. Model organisms have been used in the study of DNASE1L2 function. A conditional knockout mouse line, called Dnase1l2tm1(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice and eight significant abnormalities were observed. Homozygous mutant animals had a decreased body weight, grip strength and bone mineral content; a kinked tail, abnormal indirect calorimetry and femur/tibia morphology. Females also had an increased blood urea nitrogen level while males had a decreased leukocyte cell number. GRCh38: Ensembl release 89: ENSG00000167968 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024136 - ...
Allergic to peanuts? Chances are you avoid all tree nuts. But new research suggests that this step is not always necessary, and might actually be nutty!
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
20 October 2020... Ben Feldman news, gossip, photos of Ben Feldman, biography, Ben Feldman girlfriend list 2016. Relationship history. Ben Feldman relationship list. Ben Feldman dating history, 2020, 2019, list of Ben Feldman relationships.
25 February 2018... Ben Roethlisberger news, gossip, photos of Ben Roethlisberger, biography, Ben Roethlisberger girlfriend list 2016. Relationship history. Ben Roethlisberger relationship list. Ben Roethlisberger dating history, 2018, 2017, list of Ben Roethlisberger relationships.
And the Steelers themselves - well, words cannot express how grateful we are for the experience they gave him. Sean was taken down to the field to meet Big Ben after practice. He was in awe. He told Ben, Im your biggest fan! Ben asked him how old he was, and when he said Seven, Ben told him that was a great number! He took time out for photos and autographs, and just some really special time with Sean. Sean met a lot of Steelers yesterday and had a once in a lifetime experience. He says meeting Big Ben was his favorite part. Thank you to the Steelers organization, Steelers fans, and especially Big Ben for making this happen! - Jaclyn Madden ...
Watch Ben 10 - Season 2, Episode 12 - Dr. Animo and the Mutant Ray: The Tennysons arrive at a swamp, where the festivities of Gatorfest start first thing the next day. Gwen finds Ben playi...
x-trainer bens BodySpace profile page. Find Strength in Numbers by joining the largest fitness community! BodySpace by Bodybuilding.com
LazerTron designed by Ben Gathard for Lazer Vs. the Machines. Connect with them on Dribbble; the global community for designers and creative professionals.
Ben Doron is the author of this article in the Journal of Visualized Experiments: Tractable Mammalian Cell Infections with Protozoan-primed Bacteria
Actor Ben Affleck opened up about his recovery from alcoholism and how it affected his relationships with his ex-wife and his children.
Spencer HerathSpecial thanks to Ben OgorekBackgroundI recently faced a process with a structural change resulting in an increase in the process mean. The jump
... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... 2003). "Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166)". J ... "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule". Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, ...
... and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213-20. doi: ... domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of ... "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule ... a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137-43. PMID 2016320. Tsuge I, Utsumi KR, Ueda R, Takamoto S, ...
A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2. Mutations in the MMP2 gene ... allowing them to bind with cell receptors and influence cell signaling. Furthermore, many MMPs also activate other proMMPs ... Massagué J (July 2008). "TGFbeta in Cancer". Cell. 134 (2): 215-30. doi:10.1016/j.cell.2008.07.001. PMC 3512574. PMID 18662538 ... "Human endometrial epithelial cells modulate the activation of gelatinase a by stromal cells". Gynecol. Obstet. Invest. 53 (2): ...
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by ... These bioactive molecules play roles in coagulation, complement activation, DNA replication, cell-cycle control, cellular ... Placing a reactive group and a recognizable tag feature on the same molecule using a linker moiety gives an ABP molecule its ... Cell Proteomics 3(6):565-76 (2004). Bredemeyer A.J., Lewis R.M., Malone J.P., Davis A.E., Gross J., Townsend R.R., Ley T.J. A ...
... one of these adhesion proteins involved is ALCAM (Activated Leukocyte Cell Adhesion Molecule, also called CD166), and is under ... Apart from that, activated T-Cells can cross a healthy BBB when they express adhesion proteins. (Adhesion molecules could also ... because activated T-Cells can cross a healthy BBB when they express adhesion proteins. ... produced by CD8+ T-cells or CD20+ B-cells), creates a toxic environment that activates microglia. MRI-abnormal areas with ...
... or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial ... "E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro". Immunology. 77 (4 ... In endothelial cells, various cell-adhesion molecules including E-selectin, are shown to be upregulated upon exposure to ... E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), ...
... cell adhesion molecules, neuron-glia MeSH D12.776.395.550.200.250.150.050 - activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.395.550.200.250.520.156 - antigens, cd56 MeSH D12.776.395.550.200.250.520.578 - ... vascular cell adhesion molecule-1 MeSH D12.776.395.550.550.500 - lysosomal-associated membrane protein 1 MeSH D12.776.395.550. ... neural cell adhesion molecule l1 MeSH D12.776.395.550.200.275 - integrin alphaxbeta2 MeSH D12.776.395.550.200.450 - ...
... cell adhesion molecules, neuron-glia MeSH D23.050.301.350.250.150.050 - activated-leukocyte cell adhesion molecule MeSH D23.050 ... activated-leukocyte cell adhesion molecule MeSH D23.101.100.110.101 - antigens, cd1 MeSH D23.101.100.110.102 - antigens, cd2 ... activated-leukocyte cell adhesion molecule MeSH D23.050.301.264.035.101 - antigens, cd1 MeSH D23.050.301.264.035.102 - antigens ... neural cell adhesion molecules MeSH D23.050.301.350.250.520.156 - antigens, cd56 MeSH D23.050.301.350.250.520.578 - neural cell ...
... cell adhesion molecules, neuron-glia MeSH D12.776.543.550.200.250.150.050 - activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.543.550.200.250.520.156 - antigens, cd56 MeSH D12.776.543.550.200.250.520.578 - ... vascular cell adhesion molecule-1 MeSH D12.776.543.550.425.150 - calcium channels MeSH D12.776.543.550.425.150.400 - calcium ... neural cell adhesion molecule l1 MeSH D12.776.543.550.200.275 - integrin alphaxbeta2 MeSH D12.776.543.550.200.450 - ...
... genes that encode endothelial cell adhesion molecules, causing decreased lymphocyte and leukocyte activation and hence ... T-cells are activated and more prone to apoptosis without KLF2, suggesting that KLF2 regulates T-cell quiescence and survival. ... This activates mechanosensitive channels, which in turn activates two pathways; the MEK5/ERK5 pathway, which activates MEF2, a ... but it is also expressed temporally during embryogenesis in erythroid cells, endothelium, lymphoid cells, the spleen, and white ...
APC affects endothelial cells by inhibiting inflammatory mediator release and down-regulating vascular adhesion molecules. This ... Activated leukocytes release these inflammatory mediators during inflammation, inhibiting the creation of both thrombomodulin ... and it is these cells and leukocytes (white blood cells) that APC affects. Because of the crucial role that protein C plays as ... Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (June 2002). "Activation of endothelial cell protease activated receptor 1 ...
... cells SGEF was recruited to the intracellular domain of the transmembrane adhesion molecule ICAM-1 upon leukocyte adhesion to ... that function to activate small G proteins. In their resting state G proteins are bound to guanosine diphosphate (GDP) and ... SGEF is also expressed in endothelial cells of the vasculature. Several widely used cell lines express this protein, these ... Cell. 15 (7): 3309-19. doi:10.1091/mbc.E04-02-0146. PMC 452585. PMID 15133129. Samson et al 2013 "The Guanine-Nucleotide ...
2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes ... Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. ... Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c ( ... "Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)". Oikawa S ...
... intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells ... ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells ... Frijns CJ, Kappelle LJ (Aug 2002). "Inflammatory cell adhesion molecules in ischemic cerebrovascular disease". Stroke: A ... With the roles of ICAM-1 in cell-cell adhesion, extravasation, and infection more fully understood, a potential role for ICAM-1 ...
... vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1(ICAM-1), and E-selectin). PARs contribute to the ... For example PAR4 induces leukocyte migration and PAR2 helps macrophages to produce cytokines such as interleukin-8 (IL-8). ... Protease-activated receptor 1 Protease-activated receptor 2 Protease-activated receptor 3 Macfarlane SR, Seatter MJ, Kanke T, ... These findings suggest that TFF3 activates intestinal epithelial cells through G-protein-coupled PAR-2, and could actively ...
Concomitantly they induce local expression of adhesive molecules. Together they increase leukocytes adhesion and extravasation ... Kinin increase vascular permeability by acting on vascular endothelial cells to cause cell contraction. ... Kallikreins activate kinins when stimulated. It is a component of the kinin-kallikrein system. Their precursors are kininogens ... cell differentiation and plant development". Bioactive Natural Products (Part N). Studies in Natural Products Chemistry. 34. pp ...
β2 integrins on rolling leukocytes bind endothelial cellular adhesion molecules, arresting cell movement. ... Tight adhesion[edit]. At the same time, chemokines released by macrophages activate the rolling leukocytes and cause surface ... Leukocyte adhesion deficiency[edit]. Main article: Leukocyte adhesion deficiency. Leukocyte adhesion deficiency (LAD) is a ... white blood cells). The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to ...
... and changes in the avidity of cell adhesion molecules called integrins. Chemokines and their receptors play a crucial role in ... The subunit called Gα activates an enzyme known as Phospholipase C (PLC) that is associated with the cell membrane. PLC cleaves ... This role of chemokine is strikingly similar to their normal function of localizing leukocytes to an inflammatory site. Human ... This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location ...
... cells as well as inducing the production of costimulatory molecules that allow the cell to bind to and activate T cells more ... leading to increased expression of adhesion molecules that recruit leukocytes to infected regions. This causes inflammation in ... of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells.[2] Furthermore, Anti ... SAg activation in T-cells leads to production of CD40 ligand which activates isotype switching in B cells to IgG and IgM and ...
... binding to the intercellular adhesion molecule-1 (ICAM-1). CR3 causes phagocytosis and destruction of cells opsonized with iC3b ... A fully activated neutrophil may express on its membrane 200,000 or more CR3 molecules. Absence of CR3 results in reduced ... polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages. CR3 is a pattern ... phagocytosis and other cell-cell interactions in a variety of cells and circumstances. Upregulation of Mac-1 in the presence of ...
... and leukocytes: The inflamed blood vessels specifically express certain receptors, functioning as cell adhesion molecules, like ... Thrombosis and thrombolysis: Activated platelets are major components of blood clots (thrombi). Microbubbles can be conjugated ... Leukocytes possess high adhesion efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system. One ligand: ... and biomimicry of the leukocyte's selectin-integrin cell arrest system, having shown an increased adhesion efficiency, but yet ...
Selectins are adhesion molecules that facilitate the capture of circulating leukocytes. Sulfatide is also expressed on the ... Type 2 Natural killer T cells are able to recognize sulfatide/ CD1d tetramers, and as a result, they are activated by different ... Macrophages Dendritic cells Hepatocytes B cells Tumour cells Thymocytes Each of these different cell types are expressed in ... There are two types of cell subtypes that interact with CD1d cells: Type 1 Natural killer T cells and Type 2 Natural killer T ...
... cells as well as inducing the production of costimulatory molecules that allow the cell to bind to and activate T cells more ... leading to increased expression of adhesion molecules that recruit leukocytes to infected regions. This causes inflammation in ... and can activate up to 100% of T cells). The large number of activated T-cells generates a massive immune response which is not ... of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells. Furthermore, Anti- ...
Naïve T cells express CCR7 receptor and adhesion molecules L-selectin and LFA-1. As naïve T cells move through the circulation ... In order for an adaptive immune response to occur T cells need to be activated. T cells become activated by recognising foreign ... consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for ... HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor ...
... and their presentation to specific cell-surface receptors. The binding of versican with leukocyte adhesion molecules L-selectin ... "Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis". Nature. 457 (7225): 102-6. Bibcode: ... large family of cell adhesion molecules) with their cell surface receptors is sterically hindered. Expression of versican is ... Different tenascin domains interact with a wide range of cellular receptors, including integrins, cell adhesion molecules and ...
White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. ... C5a is an anaphylatoxin, causing increased expression of adhesion molecules on endothelium, contraction of smooth muscle, and ... C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the ... Both C5a and C5a des-Arg can trigger mast cell degranulation, releasing proinflammatory molecules histamine and TNF-α. C5a is ...
It has also been demonstrated that resistin upregulates intercellular adhesion molecule-1 (ICAM1) vascular cell-adhesion ... Inflammation is the first innate immune response to infection or irritation resulting from leukocyte (neutrophils, mast cells, ... nuclear factor kappa-light-chain-enhancer of activated B cells-mediated) fashion. ... In primates, pigs, and dogs, resistin is secreted by immune and epithelial cells, while, in rodents, it is secreted by adipose ...
... leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the ... As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. ... of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell ... However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood ...
The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are ... The rolling cancer cells then become activated by locally released chemokines present at the surface of endothelial cells. This ... action attributed to leukocytes during the leukocyte adhesion cascade. Each selectin has a carbohydrate recognition domain that ... On the other hand, several studies further show that cancer cells may initiate the expression of endothelial adhesion molecules ...
Leukocyte adhesion deficiency. *Familial cold urticaria. *Leukemia (chronic myelogenous (CML)) and other myeloproliferative ... B cells: releases antibodies and assists activation of T cells. *T cells: *CD4+ Th (T helper) cells: activate and regulate T ... T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors and CD4 molecules that, in ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ...
Cell cycle controlEdit. Cell cycle progression is controlled by ordered action of cyclin-dependent kinases (CDKs), activated by ... adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO).[123] Additionally, the UPS also plays ... a role in inflammatory responses as regulators of leukocyte proliferation, mainly through proteolysis of cyclines and the ... In the first step, a ubiquitin-activating enzyme (known as E1) hydrolyzes ATP and adenylylates a ubiquitin molecule. This is ...
"Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule ... JNK translocates to the nucleus and activates transcription factors such as c-Jun and ATF2. The JNK pathway is involved in cell ... positive regulation of leukocyte adhesion to arterial endothelial cell. • positive regulation of leukocyte adhesion to vascular ... positive regulation of heterotypic cell-cell adhesion. • negative regulation of mitotic cell cycle. • endothelial cell ...
Intracellularly, the TCR co-receptor recruits essential molecules (e.g., LCK) involved in the signaling of the activated T ... Whereas the antibody uses its Fc region to bind to Fc Receptors on leukocytes, TCR is already docked onto the cell membrane. ... The TCR is a member of the immunoglobulin superfamily, a large group of proteins involved in binding, recognition, and adhesion ... The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes,[1] that is responsible for ...
leukocyte cell-cell adhesion. • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. • positive ... P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner ... calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. • leukocyte tethering or rolling. ... "Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors". J. Cell Biol. 142 ...
... such as transporting ions and molecules across the red cell membrane, adhesion and interaction with other cells such as ... Scanning electron micrograph of blood cells. From left to right: human red blood cell, thrombocyte (platelet), leukocyte. ... as do endothelial cells.[35] Exposure of red blood cells to physiological levels of shear stress activates nitric oxide ... Red blood cells, also known as RBCs, red cells,[1] red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek ...
"Mechanisms underlying acute mast cell-induced leukocyte rolling and adhesion in vivo". Journal of Immunology. 154 (2): 804-13. ... Macrophages can also activate T cells in a similar approach (but do not do so naturally). ... The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in part, due to the presence ... that are expressed on the membranes of leukocytes including dendritic cells, macrophages, natural killer cells, cells of the ...
Also recently discovered A2B has Gq → DAG and IP3 → Release calcium → activate calmodulin → activate myosin light chain kinase ... The osteoblast cell is derived from the Mesenchymal Stem Cell (MSC) which can also differentiate into a chondrocyte.[23] The ... "Journal of Leukocyte Biology. 83 (3): 447-55. doi:10.1189/jlb.0607359. PMC 2268631. PMID 18160539.. ... Class of four receptor proteins to the molecule adenosine. Part of a series on. ...
... release of superoxide anions and changes in the avidity of cell adhesion molecules called integrins within the cell harbouring ... Furthermore, CXCR3 expression by T-cells is induced following T-cell activation and activated T-cells are attracted to sites of ... CCR9 supports the migration of leukocytes into the intestine, CCR10 to the skin and CXCR5 supports the migration of B-cell to ... Types by cell attractedEdit. *Monocytes / macrophages: the key chemokines that attract these cells to the site of inflammation ...
... altering leukocyte adhesion and proliferation, inducing apoptosis (cell death) of the lymphocytes, possibly with a toxic effect ... An uncontrolled immune response is then activated because leukocytes are not recruited to the specific site of infection, but ... Blood Cells, Molecules and Diseases. 24 (3): 340-55. doi:10.1006/bcmd.1998.0201. PMID 10087992.. ... Neutrophils, monocytes, macrophages, dendritic cells, CD4+ T cells, and B cells all undergo apoptosis, whereas regulatory T ...
Adhesion[editar , editar a fonte]. Y. pseudotuberculosis adhírese fortemente ás células intestinais por medio de proteínas ... is required for toxin targeting into the cytosol of HeLa cells". J. Biol. Chem. 275 (47): 36869-75. PMID 10930402. doi:10.1074/ ... "Yersinia enterocolitica promotes deactivation of macrophage mitogen-activated protein kinases extracellular signal-regulated ... "Role of the YadA protein in prevention of opsonization of Yersinia enterocolitica by C3b molecules". Infect. Immun. 61 (8): ...
cell death. • signal transduction. • negative regulation of gastric acid secretion. • phospholipase C-activating G-protein ... Journal of Leukocyte Biology. 68 (2): 187-93. PMID 10947062.. ... E receptor EP3 subtype from human erythroleukaemia cells". The ... adenylate cyclase-activating G-protein coupled receptor signaling pathway. • positive regulation of cytosolic calcium ion ... "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells". Inflammation ...
Some such nerve cells have been shown to contain guanylate cyclase, an enzyme that is activated by carbon monoxide.[15] ... See also: Gaseous signaling molecules. Carbon monoxide is produced naturally by the human body as a signaling molecule. Thus, ... stimulate leukocyte phagocytosis of bacteria, and reduce the production of pro-inflammatory cytokines by leukocytes. In animal ... inhibits blood platelet aggregation and adhesion, suppresses, reverses, and repairs the damage caused by inflammatory responses ...
This reduced leukocyte adhesion is an important step in the immune response to infection; however, evidence is insufficient to ... In 2012, salicylic acid was found to activate AMP-activated protein kinase, which has been suggested as a possible explanation ... each salicylic molecule forms the same hydrogen bonds with two neighboring molecules instead of one. With respect to the ... Pugliese A, Beltramo T, Torre D (October 2008). "Reye's and Reye's-like syndromes". Cell Biochemistry and Function. 26 (7): 741 ...
... and changes in the avidity of cell adhesion molecules called integrins.[6] Chemokines and their receptors play a crucial role ... The subunit called Gα activates an enzyme known as Phospholipase C (PLC) that is associated with the cell membrane. PLC cleaves ... Kakinuma, Takashi; Hwang, Sam T. (2006-04-01). "Chemokines, chemokine receptors, and cancer metastasis". Journal of Leukocyte ... This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location ...
... α-gliadin stimulates membrane cells, enterocytes, of the intestine to allow larger molecules around the sealant between cells. ... One locus, the LPP or lipoma-preferred partner gene, is involved in the adhesion of extracellular matrix to the cell surface, ... also called the human leukocyte antigen) system and distinguishes cells between self and non-self for the purposes of the ... Therefore, these forms of the receptor are more likely to activate T lymphocytes and initiate the autoimmune process.[28] ...
Exogenous antigens are usually displayed on MHC class II molecules, which activate CD4+T helper cells.[2] ... Neutralization: Blocks adhesion of bacteria and viruses to mucosa. Like the T cell, B cells express a unique B cell receptor ( ... also known in humans as human leukocyte antigen (HLA)). This MHC: antigen complex is recognized by T-cells passing through the ... When B cells and T cells are activated some become memory B cells and some memory T cells. Throughout the lifetime of an animal ...
... intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1).[21] ... as well as expression of leukocyte adhesion molecules such as E-selectin, ... by natural killer cells which accumulate in and damage the xenograft and T-lymphocytes which are activated by MHC molecules ... T cells. Antigens of phagocytosed graft cells can also be presented by the host's class I MHC molecules to CD8+ T cells.[1][29] ...
negative regulation of fat cell differentiation. • negative regulation of leukocyte activation. • apoptotic chromosome ... are water-soluble proteins located in the interior of cells that are activated by estrogenenic hormones such as estradiol and ... cell nucleus. • cell projection. • mitochondrial membrane. • keratin filament. • dendritic shaft. • dendritic spine head. • ... cell differentiation. • immune system process. • negative regulation of cell cycle process. • positive regulation of release of ...
leukocyte migration. • cell adhesion mediated by integrin. • platelet activation. • apoptotic cell clearance. • regulation of ... cell adhesion molecule binding. • neuregulin binding. • coreceptor activity. • fibroblast growth factor binding. • insulin-like ... "The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. 277 (24): 21749-58. doi:10.1074/jbc. ... smooth muscle cell migration. • positive regulation of endothelial cell migration. • cell growth. • cell-substrate adhesion. • ...
... and leukocytes: *The inflamed blood vessels specifically express certain receptors, functioning as cell adhesion molecules, ... Thrombosis and thrombolysis: Activated platelets are major components of blood clots (thrombi). Microbubbles can be conjugated ... Leukocytes possess high adhesion efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system.[15] One ligand ... and biomimcry of the leukocyte's selectin-integrin cell arrest system,[18] having shown an increased adhesion efficiency, but ...
... even in the absence of surface adhesion molecules and antigenic peptides. This role of NK cells is critical to immune success ... an activating biochemical receptor that binds the Fc portion of IgG class antibodies. This allows NK cells to target cells ... These uNK cells are the most abundant leukocytes present in utero in early pregnancy, representing about 70% of leukocytes here ... NK cells are thought to be an important cell type in this process.[17] These cells are known as "uterine NK cells" (uNK cells) ...
Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help". Journal of Immunology. 149 (12): ... but the integrin protein LFA-1 on the T cell and ICAM on the APC are the primary molecules of adhesion in this cell interaction ... With the assistance of a phosphatase present on the intracellular section of CD45 (common leukocyte antigen), these molecules ... Their main effector cells are NK cells as well as CD8 T cells, IgG B cells, and IL-10 CD4 T cells. The key THαβ transcription ...
... constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction ... King N, Hittinger CT, Carroll SB (July 2003). "Evolution of key cell signaling and adhesion protein families predates animal ... Journal of Leukocyte Biology. 93 (4): 521-8. doi:10.1189/jlb.0712328. PMID 23345392.. ... In mammalian cells, the much-studied β2-adrenoceptor has been demonstrated to activate the ERK2 pathway after arrestin-mediated ...
... altering leukocyte adhesion and proliferation, inducing apoptosis (cell death) of the lymphocytes, possibly with a toxic effect ... An uncontrolled immune response is then activated because leukocytes are not recruited to the specific site of infection, but ... Blood Cells, Molecules & Diseases 24 (3): 340-55։ September 1998։ PMID 10087992։ doi:10.1006/bcmd.1998.0201 ,vauthors=. ... Upon detection of microbial antigens, the host systemic immune system is activated. Immune cells not only recognise pathogen- ...
Cell surface receptors allow neutrophils to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon ... In addition to recruiting and activating other cells of the immune system, neutrophils play a key role in the front-line ... 2006). "Neisseria gonorrhoeae delays the onset of apoptosis in polymorphonuclear leukocytes". Cell Microbiol. 8 (11): 1780-90. ... and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into ...
Also, at an adhesion called the fibronexus, actin in the myofibroblast is linked across the cell membrane to molecules in the ... Other leukocytes to enter the area include helper T cells, which secrete cytokines to cause more T cells to divide and to ... Activated endothelial cells respond by retracting and reducing cell junctions, loosening themselves from their embedded ... Stem cells give rise to progenitor cells, which are cells that are not self-renewing, but can generate several types of cells. ...
feG and related peptides are known to modulate leukocyte (white blood cells) activity by influencing cell surface receptors to ... One lead ImSAID, the tripeptide FEG (Phe-Glu-Gly) and its D-isomer feG are known to alter leukocyte adhesion involving actions ... One SGP-T derivative is a three-amino acid sequence shown to be a potent anti-inflammatory molecule with systemic effects. This ... One of the neuroendocrine pathways, when activated, results in the release of immune-regulating peptides from the submandibular ...
... for Chemoattractant Receptor-homologous molecule expressed on T-Helper type 2 cells). In addition to these T helper cells, DP2 ... Ligands that activate DP2 stimulate the in vitro chemotaxis (i.e. directed migration) of leukocytes active in mediating ... an increase in the expression of DP2 by these cells, an enhanced rate of differentiation of precursor cells to Th2 cells in ... As evidenced by its initial discovery as a receptor for PGD2 in T-helper type 2 cells, activated DP2 triggers Gi alpha subunit- ...
B cells. Eosinophils. Langerhans cells Possible adhesion molecule. IgE transport across human intestinal epithelium. Positive- ... CD4+ T cells provide help to B cells that produce antibodies. Several subsets of activated effector CD4+ T cells are observed ... Journal of Leukocyte Biology. 76 (6): 1093-103. doi:10.1189/jlb.0804439. PMID 15466916.. ... cells stimulate the NK cells to release cytotoxic molecules from their granules to kill antibody-covered target cells.[22] Fc ...
Activated Leukocyte Cell Adhesion Molecule), Authors: Esra Yavuz, Merve Oyken, Ayse Elif Erson Bensan. Published in: Atlas ... of plasma membrane focal adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ... of plasma membrane focal adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ... Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell ...
Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a marker of various cancers and mesenchymal stem cells, is ... Cell, Tumor, and Stem Cell Biology Attenuation of Melanoma Invasion by a Secreted Variant of Activated Leukocyte Cell Adhesion ... Aberrant expression profiles of activated leukocyte cell adhesion molecule (ALCAM/MEMD/CD166) were reported in a series of ... Remarkably, L1 neuronal cell adhesion molecule (L1CAM/CD171), another progression marker of several cancers including melanoma ...
OMIM: ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALCAM*Gene Ontology: Alcam *Mouse Phenome DB: Alcam *UCSC: Chr.16:52,248,996- ... activated leukocyte cell adhesion molecule. Synonyms: BEN, CD166, DM-GRASP, MuSC, SC1. Gene nomenclature, locus information, ... Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International ...
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Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ...
Activated leukocyte cell adhesion molecule (ALCAM) is expressed on various cell types, including leukocytes, endothelial cells ... Activated leukocyte cell adhesion molecule (ALCAM) is expressed on various cell types, including leukocytes, endothelial cells ... Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis ZORA Maintenance. ... Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis. American Journal of ...
Activated Leukocyte Cell Adhesion Molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin. ... Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity ... You are here: Lirias › KU Leuven › Biomedical Sciences Group › Department of Imaging & Pathology › Translational Cell & Tissue ... of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions ...
Mesenchymal Stem Cell Surface Antigen SB-10 Corresponds to Activated Leukocyte Cell Adhesion Molecule and Is Involved in ... we report on the immunopurification of the SB-10 antigen and its identification as activated leukocyte-cell adhesion molecule ( ... thereby implicating a role for ALCAM during bone morphogenesis and adding ALCAM to the group of cell adhesion molecules ... The cell surface antigen recognized by monoclonal antibody SB-10 is expressed on human MSCs but is lost during their ...
An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in ... Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients. Last ...
Cavy Activated Leukocyte Cell Adhesion Molecule ELISA Kit-AAB59499.1 (MBS046317) product datasheet at MyBioSource, ELISA Kits ... Activated Leukocyte Cell Adhesion Molecule (ALCAM), ELISA Kit. Also Known As Cavy Activated Leukocyte Cell Adhesion Molecule ... Cell Adhesion Molecules (CAMs) Pathway Diagram. Cell Adhesion Molecules (CAMs) Pathway antibodies. Cell Adhesion Molecules ( ... This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), ...
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Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]. Wound Repair ... Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract] ... Our purpose was assess the impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM) on Human Vascular Endothelial Cells ( ... the following cell sublines were created; a control (HECVpEF) endothelial cell line and a ALCAM-knockdown (HECVALCAM/KD) cell ...
Click here for Leukocyte adhesion molecule deficiency pictures! You can also find pictures of Itchy red bump disease, Lentigo ... hsa:214 ALCAM; activated leukocyte cell adhesion molecule hsa:914 CD2; CD2 molecule hsa:933 CD22;... Figure 2. Sequence ... Leukocyte Adhesion Process... From Horwitz Adhesion molecules involved in leukocyte emigration from vessels during inflammation ... Figure 1: Leukocyte migration from the circulation into target tissues is a multi-step process. The... Figure 1: Leukocyte ...
Activated leukocyte cell adhesion molecule (ALCAM) is a type I transmembrane protein member of the immunoglobulin superfamily ... Syntenin-1 and ezrin link Activated Leukocyte Cell Adhesion Molecule to the actin cytoskeleton. Publication. Publication. J. ... Syntenin-1 and ezrin link Activated Leukocyte Cell Adhesion Molecule to the actin cytoskeleton. J. Biol. Chem., 289(19), 13445- ... of cell adhesion molecules. Involved in important pathophysiological processes such as the immune response, cancer metastasis, ...
1B). To evaluate the effect on adhesion molecules, cells were activated with the vehicle, S1P, LPS, or a combination of S1P and ... Analysis of endothelial cell-leukocyte adhesion. Cell-cell adhesion was evaluated by using a parallel-plate flow chamber ... leukocyte-endothelial cell adhesion by significantly increasing cell adhesion strength and the number of attached leukocytes. ... consequences of the upregulation of adhesion molecules in endothelial cells by analyzing leukocyte-endothelial adhesion under ...
Activated-Leukocyte Cell Adhesion Molecule , Animals , Dendritic Cells , Dermatitis, Atopic , Gene Expression , Humans , ... Activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily, is highly expressed on ... Activated Leukocyte Cell Adhesion Molecule Modulates Th2 Immune Response in Atopic Dermati ... Activated Leukocyte Cell Adhesion Molecule Modulates Th2 Immune Response in Atopic Dermatitis ...
... on monocyte-lineage cells and in rheumatoid arthritis synovium. ... expression of activated leukocyte cell adhesion molecule (CD166 ... Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid ... OBJECTIVE: To determine whether monocyte/macrophage expression of the CD6 ligand, activated leukocyte cell adhesion molecule ( ... ALCAM was expressed on monocyte-lineage cells in situ in inflamed synovium from patients with RA (9 of 9), but not in ...
IMMUNOGLOBULIN SUPERFAMILY/CELL ADHESION MOLECULES (PROTEINS AND PEPTIDES); LEUKOCYTES + AMOEBOID BLOOD CELLS (BLOOD CELLS); ... Investigating the role of activated leukocyte cell adhesion molecule in vascular biology and its potential as a therapeutic ... TUMOUR GROWTH, GROWTH AND PROLIFERATION OF CANCER CELLS (PATHOLOGY); IMMUNE REACTION + IMMUNE RESPONSE (IMMUNOLOGY) ...
... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ...
Background Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a member of the immunoglobulin superfamily that ... Activated Leukocyte Cell Adhesion Molecule Expression Is Up-Regulated in the Development of Endometrioid Carcinoma ... Activated Leukocyte Cell Adhesion Molecule Expression Is Up-Regulated in the Development of Endometrioid Carcinoma ... contributes to cell migration. The present study investigated the potential role of ALCAM in the transition from normal ...
Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in ... lung adenocarcinoma or melanoma cells to upregulate endothelial ALCAM. At selected time-points, mice were injected ... Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in ... A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in ...
In this study, we investigated the role of activated leukocyte cell adhesion molecule (ALCAM/CD166), a member of the ... Here, we show that the viral transactivator Tax increases activated leukocyte cell adhesion molecule (ALCAM/CD166) expression. ... Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates ... Example: +cell +stem * Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.. Example: +cell - ...
In this study, we investigated the role of activated leukocyte cell adhesion molecule (ALCAM/CD166), a member of the ... Here, we show that the viral transactivator Tax increases activated leukocyte cell adhesion molecule (ALCAM/CD166) expression. ... This molecule facilitates the migration of lymphocytes across the BBB endothelium. Targeting this molecule could be of interest ... We demonstrated that ALCAM is overexpressed on the surface of HTLV-1-infected lymphocytes, both in chronically infected cell ...
  • ALCAM (Activated Leukocyte Cell Adhesion Molecule), also known as CD166 (cluster of differentiation 166), is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. (atlasgeneticsoncology.org)
  • Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a marker of various cancers and mesenchymal stem cells, is involved in melanoma metastasis. (aacrjournals.org)
  • Partial cDNA sequences of bovine CD72 and CD166/ALCAM, ligands for SRCR-family accessory molecules CD5 and CD6. (umassmed.edu)
  • Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity of human melanoma cell lines (Am J Pathol 1998, 152:805-813). (kuleuven.be)
  • Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium. (duke.edu)
  • OBJECTIVE: To determine whether monocyte/macrophage expression of the CD6 ligand, activated leukocyte cell adhesion molecule (ALCAM) (CD166), is regulated by cytokines during inflammation in rheumatoid arthritis (RA). (duke.edu)
  • Background Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a member of the immunoglobulin superfamily that contributes to cell migration. (bmj.com)
  • In this study, we investigated the role of activated leukocyte cell adhesion molecule (ALCAM/CD166), a member of the immunoglobulin superfamily, in the crossing of the BBB by HTLV-1-infected lymphocytes. (pasteur.fr)
  • Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a 105-kDa transmembrane glycoprotein linked with cell migration and development and with cancer progression (malignant melanoma, prostate cancer and, very recently, breast cancer). (nih.gov)
  • This report is the first evaluation of ALCAM/CD166 in an estrogen-dependent (MCF-7) and a metastatic (MDA-MB-231) breast cancer cell line and a reference breast cell line (HBL-100). (nih.gov)
  • The effects of estrogen and anti-estrogen treatment, bcl-2 overexpression, and ALCAM gene silencing on ALCAM/CD166 protein concentration and cell survival were investigated. (nih.gov)
  • 17-beta-estradiol increased and tamoxifen inhibited ALCAM/CD166 expression and survival of MCF-7 cells. (nih.gov)
  • Overexpression of the bcl2 gene in MCF-7 bcl2/neo, MDA-MB-231 bcl2/neo, and HBL-100 bcl2/neo cells significantly increased ALCAM/CD166 expression and was accompanied by decreasing MMP-2 concentrations. (nih.gov)
  • Appearance of the ALCAM/CD166 protein was noted in HBL-100 bcl2/neo in contrast to an almost undetectable level in HBL-100 cells. (nih.gov)
  • Impaired expression of ALCAM/CD166 is associated with the induction of two types of programmed cell death, apoptosis and autophagy, in breast cancer cells. (nih.gov)
  • Studies have shown that long-term interactions between activated leucocyte cell adhesion molecule (ALCAM/CD166) on the surface of antigen-presenting cells, and CD6, a co-stimulatory molecule, influence immune responses. (yonsei.ac.kr)
  • Colorectal cancer stem cells (CSCs) are responsible for the initiation, progression and metastasis of human colorectal cancers, and have been characterized by the expression of cell surface markers, such as CD44, CD133, CD166 and LGR5. (mdpi.com)
  • The Human ALCAM/CD166 (Hu ALCAM) ELISA quantitates Hu ALCAM in human serum, plasma, or cell culture medium. (thermofisher.com)
  • CD166 is involved in neurite extension by neurons via heterophilic and homophilic interactions, and may play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. (thermofisher.com)
  • CD166) is a 105 kD cell-surface adhesion molecule belonging to the Ig superfamily of receptors. (fishersci.com)
  • Activated Leukocyte Cell Adhesion Molecule (CD166): An "Inert" Cancer Stem Cell Marker for Non-Small Cell Lung Cancer? (wiley.com)
  • citation needed] CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma. (wikipedia.org)
  • CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. (wikipedia.org)
  • citation needed] Recently, CD166 has also been used as a potential cancer stem cell marker. (wikipedia.org)
  • Introduction: Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) gained increasing attention regarding tumorprogression and metastatic spread in breast cancer. (iospress.com)
  • CD166 and CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T cells and B cells to activated leukocytes. (prospecbio.com)
  • FACS analysis of JURKAT cells using GTX60782 CD166 antibody [8E12C7]. (genetex.com)
  • ICC/IF analysis of HeLa cells using GTX60782 CD166 antibody [8E12C7]. (genetex.com)
  • WB analysis of HEK293 (1) and CD166(AA: 48-216)-hIgGFc transfected HEK293 (2) cell lysate using GTX60782 CD166 antibody [8E12C7]. (genetex.com)
  • FACS analysis of NCI-H292 cells using GTX81961 CD166 antibody, N-term. (genetex.com)
  • WB analysis of NCI-H460 cell lysate (35ug/lane) using GTX81961 CD166 antibody, N-term. (genetex.com)
  • ALCAM (activated leukocyte cell adhesion molecule), designated CD166, is a 100‑110 kDa type I transmembrane glycoprotein and a member of the Ig CAM family within the immunoglobulin superfamily (1). (rndsystems.com)
  • Rat ALCAM / CD166 derived in Human Cells. (creativebiomart.net)
  • We show that expression of CD6 in T cells limits their responsiveness but that engagement by the physiological ligand CD166 gives costimulation. (asm.org)
  • CD6 is highly expressed on resting T cells, whereas CD166 is expressed on antigen-presenting cells, consistent with engagement of CD6 by CD166 being necessary for optimal antigen-specific T-cell activation ( 19 ). (asm.org)
  • Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells. (semanticscholar.org)
  • Activated leukocyte cell adhesion molecule (ALCAM or CD166) modulates bone phenotype and hematopoiesis. (stembook.org)
  • Activated leukocyte cell adhesion molecule (ALCAM, also known as CD166) is a cell adhesion molecule that belongs to the immunoglobulin superfamily. (ptglab.com)
  • 6 Similarly, CD166 expressing OBs were reported to play an important role in supporting quiescent long-term repopulating cells. (bloodjournal.org)
  • abstract = "Human immunodeficiency virus (HIV)-associated increase in monocyte adhesion and trafficking is exacerbated by cocaine abuse. (elsevier.com)
  • Abstract Objective: Mast cell infiltration into airway smooth muscle (ASM) bundle is an important feature of asthma. (jove.com)
  • a control (HECVpEF) endothelial cell line and a ALCAM-knockdown (HECVALCAM/KD) cell line. (cf.ac.uk)
  • Consistent with an increase in adhesion molecule expression, endothelial cell treatment with LPS plus S1P significantly enhanced adhesion of PBMCs under shear stress conditions compared with the effect of either ligand alone and exhibited comparable levels of cell adhesion strength as those after TNF-α treatment. (jimmunol.org)
  • 3-5 Thereafter, integrins with other molecules accomplish the final transmigration step, which may occur via endothelial cell junctions or through a transcytotic route. (ahajournals.org)
  • During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. (ebi.ac.uk)
  • Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. (ebi.ac.uk)
  • ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. (ebi.ac.uk)
  • Immediately after endothelial cell injury, endothelial cells and platelets are activated promoting the expression of cell adhesion molecules. (ahajournals.org)
  • Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8. (abnova.com)
  • In addition, in a cell culture model, irisin restored ox-LDL-induced human umbilical vein endothelial cell dysfunction by reducing the levels of inflammatory genes via inhibiting the reactive oxygen species (ROS)/ p38 MAPK/ NF-κB signaling pathway activation and inhibiting cell apoptosis via up-regulating Bcl-2 and down-regulating Bax and caspase-3 expression. (plos.org)
  • Also, our recent study showed that irisin promotes human umbilical vein endothelial cell (HUVEC) survival and proliferation via the ERK signaling pathway [ 19 ]. (plos.org)
  • Recently, a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the endothelium. (elsevier.com)
  • We now show that upregulation of ALCAM in the brain endothelium seen in HIV + /cocaine drug abusers paralleled increased CD68 immunostaining compared with HIV + /no cocaine or uninfected controls, suggesting the important role of ALCAM in promoting leukocyte infiltration across the BBB. (elsevier.com)
  • 1,2 On an inflammatory reaction, activated lymphocytes together with other subclasses of leukocytes recognize the inflamed endothelium at the site of insult and migrate into peripheral tissues. (ahajournals.org)
  • ALCAM is expressed on thymic epithelium, microvascular endothelium, activated lymphocytes and monocytes, and monocyte-derived dendritic cells. (prospecbio.com)
  • This process is predominantly mediated by cellular adhesion molecules, which are expressed on the vascular endothelium and on circulating leukocytes in response to several inflammatory stimuli. (hindawi.com)
  • Disruption of these molecular interactions prevents transmigration of mononuclear leukocytes across the endothelium into inflamed parenchymal tissue. (intekom.com)
  • Through its ability to express procoagulants and anticoagulants, vasoconstrictors, and vasodilators, as well as key cell adhesion molecules and cytokines, the endothelium has emerged as one of the pivotal regulators of hemostasis. (ahajournals.org)
  • In addition, the elaboration of NO, prostacyclin, and interleukin (IL)-10 by endothelium inhibits the adhesion and activation of leukocytes and produces vasodilation. (ahajournals.org)
  • This vascular response promotes leukocyte rolling and tethering onto the endothelium that initiates an inflammatory event which can lead to thrombosis. (ahajournals.org)
  • When leucocyte microvilli touch the endothelium, several different adhesion pathways can function either alone or in concert to mediate tethering. (els.net)
  • In addition, ALCAM-ALCAM homophilic interaction contributes to cellular changes, such as angiogenesis, immune response and cell migration during the neuronal development (van Kempen et al. (atlasgeneticsoncology.org)
  • We have exploited a secreted NH 2 -terminal fragment, sALCAM, to test the hypothesis that ALCAM coordinates tissue growth and cell migration. (aacrjournals.org)
  • In general, dynamic modulation of cell adhesion is crucial for tissue architecture, growth, and migration. (aacrjournals.org)
  • This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. (mybiosource.com)
  • We then assessed the impact of ALCAM on cellular migration of the endothelial cells by way of electric wounding using Electrical Cell Impedence Sensing (ECIS) zy model. (cf.ac.uk)
  • Our results concur with those previously reported in cancer cells suggesting knockdown of ALCAM increases cellular migration and our results have shown this to also be true for endothelial cells. (cf.ac.uk)
  • ALCAM blockade or downregulation of ALCAM levels significantly reduced the migration of HTLV-1-infected lymphocytes across a monolayer of human BBB endothelial cells. (pasteur.fr)
  • Leukocyte migration from the circulation into target tissues is a multi-step process. (picsearch.com)
  • Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that mediates a wide spectrum of cell functions in both intracellular and extracellular compartments, which includes proliferation, migration, differentiation, angiogenesis, and lymphocyte trafficking ( 1 - 3 ). (jimmunol.org)
  • Here we briefly review the role of vascular adhesion protein-1 (VAP-1) and CD73, 2 cell surface enzymes, in leukocyte migration form the blood into the tissues. (ahajournals.org)
  • JAM family and related proteins in leukocyte migration. (ahajournals.org)
  • The immune defense is dependent on proper migration of leukocytes between the blood and tissues. (ahajournals.org)
  • One early phase of atherosclerosis involves the recruitment of inflammatory cells from the circulation and their endothelial migration [ 9 ]. (hindawi.com)
  • ALCAM mediates low‑affinity adhesion with itself or the cysteine‑rich scavenger receptor CD6 to regulate T cell development, immunological synapses (IS), and cell migration through endothelial junctions (1‑11). (rndsystems.com)
  • Leukocyte migration across the BBB involves interaction between adhesion molecules on inflammatory cells and endothelial cells of the vessel wall. (intekom.com)
  • eATP induces mast cells migration by acting through purinergic receptors. (jove.com)
  • Whether eATP participates in the migration of mast cell towards ASM cells is still unknown. (jove.com)
  • In the present study, we demonstrated that exposure of human brain microvascular pericytes and C3H/10T1/2 cells to HIV-1 Tat101 resulted in increased expression of platelet-derived growth factor subunit B homodimer (PDGF-BB) and increased migration of the treated cells. (jneurosci.org)
  • Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration," FEBS Letters , vol. 580, no. 11, pp. 2637-2645, 2006. (hindawi.com)
  • Akt, also known as protein kinase B (PKB), is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. (jcancer.org)
  • The absence of ALCAM expression in cells forming the stromal tumor microenvironment profoundly affected lung tumor growth in three different i.v. metastasis models. (uzh.ch)
  • Similarly, when LLC cells were implanted subcutaneously for the study of spontaneous tumor cell metastasis, the rate of LLC metastasis to the lungs was profoundly reduced in ALCAM-/- mice. (uzh.ch)
  • Involved in important pathophysiological processes such as the immune response, cancer metastasis, and neuronal development, ALCAM undergoes both homotypic interactions with other ALCAM molecules and heterotypic interactions with the surface receptor CD6 expressed at the T cell surface. (amolf.nl)
  • Subsequently, in a proof-of-concept study, mouse models of brain metastasis were induced by intracardial injection of brain-tropic human breast carcinoma, lung adenocarcinoma or melanoma cells to upregulate endothelial ALCAM. (ox.ac.uk)
  • The difficulty to cure advanced colorectal cancers is at least partly attributed to the presence of a small population of highly-tumorigenic cancer cells termed cancer stem cells (CSCs) which are responsible for the initiation, progression and metastasis of colorectal cancer [ 2 , 3 , 4 , 5 , 6 ]. (mdpi.com)
  • My research has most recently focused on the metastasis of prostate cancer to bone, looking specifically at the factors involved in the osteoblastic phenotype exhibited by prostate cancer, in addition to the interactions between prostate cancer cells and the permissive bone microenvironment that allow secondary tumours to develop and progress at these sites. (cardiff.ac.uk)
  • Cleavage of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis? (cancerprev.org)
  • The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling. (ptglab.com)
  • METHODS: We used flow cytometry to test whether cytokines present in rheumatoid synovium could regulate ALCAM cell surface expression on peripheral blood (PB) monocytes and RA synovial fluid (SF) macrophages, and we examined ALCAM expression in situ in RA synovium by immunofluorescence. (duke.edu)
  • Furthermore, in vitro culture-induced ALCAM expression on PB monocytes and CD14+ RA SF cells was inhibited by an M-CSF neutralizing antibody. (duke.edu)
  • Monocytes prime autoreactive T cells after myocardial infarction. (uc.edu)
  • ALCAM is expressed on activated T cells, B cells, monocytes, skin fibroblasts, keratinocytes and rheumatoid arthritis synovium, and mediates homophilic and heterophilic adhesion. (biomedcentral.com)
  • Cancer is frequently accompanied by aberrant distributions and/or functions of cell adhesion molecules, e.g., involving members of the cadherin and/or immunoglobulin families ( 1 - 3 ). (aacrjournals.org)
  • Activated leukocyte cell adhesion molecule (ALCAM) is a type I transmembrane protein member of the immunoglobulin superfamily of cell adhesion molecules. (amolf.nl)
  • Activated leukocyte cell adhesion molecule ( ALCAM ), a member of the immunoglobulin superfamily, is highly expressed on dendritic cells . (bvsalud.org)
  • Traditionally molecules belonging to selectin, chemokine, integrin, and immunoglobulin super families are thought to mediate the multiple adhesive and activation events needed for a successful emigration cascade. (ahajournals.org)
  • CD6 binds activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily (IgSF). (biomedcentral.com)
  • CD6 and CD5 are unusual in that their extracellular regions are comprised of scavenger receptor cysteine-rich domains instead of the more-common immunoglobulin (Ig)-like domains found in other T-cell surface proteins, such as CD2, CD4, CD8, etc. (asm.org)
  • When a rolling cell encounters a chemoattractant stimulus such as a chemokine, the activating signal induces rapid activation of β 2 or α 4 integrins, which bind to endothelial immunoglobulin superfamily members. (els.net)
  • Activated leukocyte cell adhesion molecule (ALCAM) is a typeI membrane glycoprotein that is a member of the immunoglobulin superfamily. (rndsystems.com)
  • The addition of antibody SB-10 Fab fragments to human MSCs undergoing osteogenic differentiation in vitro accelerated the process, thereby implicating a role for ALCAM during bone morphogenesis and adding ALCAM to the group of cell adhesion molecules involved in osteogenesis. (ovid.com)
  • Many of the actions of S1P are mediated by the activation of receptors, initially known as endothelial differentiation genes and now designated as S1P 1-5 , which are high-affinity receptors coupled to G proteins (α io , α q , or α 12/13 ) that trigger the activation of multiple signals leading to specific cell responses ( 4 ). (jimmunol.org)
  • miRNAs regulate a variety of cell functions, including cell proliferation, stem cell maintenance and differentiation. (mdpi.com)
  • We previously identified miRNAs, such as miR-200 families and miR-142, can target key elements of the self-renewal and multi-lineage differentiation pathways in human breast CSCs and normal mammary stem/progenitor cells by analysis of the surgical specimens of human breast cancer patients [ 9 , 10 ]. (mdpi.com)
  • Adipose-derived stem cells are easily obtained, show a strong capacity for ex vivo expansion and differentiation to other cell types, release a large variety of angiogenic factors, and have immunomodulatory properties. (revespcardiol.org)
  • 2020. Human basal cell carcinoma: the induction of anagen hair follicle differentiation . (cardiff.ac.uk)
  • Pubmed ID: 11927625 c-Jun NH(2)-terminal kinases (JNK) play important roles in T helper cell (Th) proliferation, differentiation, and maintenance of Th1/Th2 polarization. (jove.com)
  • 2018. HPV-induced field cancerisation: Transformation of adult tissue stem cell into cancer stem cell . (cardiff.ac.uk)
  • Remarkably, L1 neuronal cell adhesion molecule (L1CAM/CD171), another progression marker of several cancers including melanoma, was suppressed upon sALCAM overexpression but was up-regulated by ΔN-ALCAM. (aacrjournals.org)
  • Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. (genome.jp)
  • ALCAM shows a characteristic, temporal, and spatial distribution in development of a wide variety of tissues and cells in health and disease. (aacrjournals.org)
  • Bone marrow contains a rare population of mesenchymal stem cells (MSCs) capable of giving rise to multiple mesodermal tissues including bone, cartilage, tendon, muscle, and fat. (ovid.com)
  • T cell proliferation of total cells, CD3(+) CD4(+) T cells and activated T cells in immune tissues were diminished in OVA-challenged ALCAM(-/-) mice. (yonsei.ac.kr)
  • Leukocyte extravasation from the blood into tissues is crucial for normal immune surveillance and in inflammation. (ahajournals.org)
  • While healthy people need ALCALM to activate their T cells to fight off foreign microbes in the body, in patients with an autoimmune disease, the activated T cells end up just fighting the patient's own tissues, rather than a foreign body. (eurekalert.org)
  • A further mechanism of action of natalizumab may be to suppress ongoing inflammatory reactions in diseased tissues by inhibiting the interaction of alpha4-expressing leukocytes with their ligands in the extracellular matrix and on parenchymal cells. (intekom.com)
  • As such, natalizumab may act to suppress inflammatory activity present at the disease site, and inhibit further recruitment of immune cells into inflamed tissues. (intekom.com)
  • Leucocytes must interact with other cells and extracellular matrix molecules to migrate from the bloodstream to lymphoid and nonlymphoid tissues, to detect and respond to antigen and to exert immune functions. (els.net)
  • B cells are the predominant subset in most mucosa‐associated lymphoid tissues, whereas T cells are more frequent in peripheral LNs. (els.net)
  • Effector memory cells migrate preferentially to nonlymphoid tissues. (els.net)
  • Identification of the molecular mechanism underlying ALCAM-mediated adhesion will further contribute to our understanding of the function of ALCAM in diverse tissues. (biologists.org)
  • Multipotent mesenchymal stromal cells (MSCs) are essential bone marrow components that have the potential to differentiate in vitro into tissues along mesenchymal lineages, including bone marrow stroma. (springer.com)
  • Analysis of precursor cells for osteogenic and hematopoietic tissues. (springer.com)
  • Devine SM, Cobbs C, Jennings M et al (2003) Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. (springer.com)
  • It was associated with decreased inflammation and cell apoptosis in aortic tissues. (plos.org)
  • The underlying mechanisms involve cocaine-mediated up regulation of adhesion molecules with subsequent disruption of the blood- brain barrier (BBB). (elsevier.com)
  • MicroRNAs (miRNAs) are differentially expressed between CSCs and non-tumorigenic cancer cells, and play important roles in the maintenance and regulation of stem cell properties of CSCs. (mdpi.com)
  • Of the eight known members, SOCS1 and SOCS3 in conjunction with regulatory T cells play key roles in regulation of the immune system. (frontiersin.org)
  • The concept of enzymatic regulation of leukocyte extravasation provides new insight into the multi-step adhesion cascade and opens new possibilities for inhibiting inappropriate inflammatory reaction through the use of small molecule enzyme inhibitors. (ahajournals.org)
  • CD6-ligand interaction has been implicated in cell adhesion, T-cell maturation and regulation of activation, constituting an uncommon type of protein-protein superfamilies interaction. (biomedcentral.com)
  • The results have implications for regulation by CD6 and the related T-cell surface protein, CD5. (asm.org)
  • In view of the diversity of cellular processes in which ALCAM is implicated, tight regulation of ALCAM-mediated adhesion is required to prevent aberrant adhesive homotypic or heterotypic interactions. (biologists.org)
  • K562 cells expressing a GPI-anchored ALCAM mutant failed to adhere to immobilized ALCAM-Fc in response to CytD treatment, demonstrating the importance of the cytoplasmic domain of ALCAM for regulation by the actin cytoskeleton. (biologists.org)
  • Although HSC niches have been extensively characterized, the role of endosteal osteoblasts (OBs) in HSC regulation requires further clarification, and the role of OBs in regulating leukemic stem cells (LSCs) is not well studied. (bloodjournal.org)
  • Furthermore, ALCAM expression was increased in cocaine-treated mice with concomitant increase in monocyte adhesion and transmigration in vivo, which was ameliorated by pretreating with the neutralizing antibody to ALCAM, lending additional support to the role of ALCAM. (elsevier.com)
  • Functional implication of upregulated ALCAM was confirmed using cell adhesion and transmigration assays. (elsevier.com)
  • Together, these findings implicate cocaine-mediated induction of ALCAM as a mediator of increased monocyte adhesion/transmigration into the CNS. (elsevier.com)
  • In the setting of central nervous system (CNS) inflammation in MS, it is the interaction of alpha4beta1 with VCAM-1, CS-1 and osteopontin that mediates the firm adhesion and transmigration of leukocytes into the brain parenchyma and may perpetuate the inflammatory cascade in CNS tissue. (intekom.com)
  • Cell adhesion molecules (CAMs) allow leukocyte transmigration, and selectins (P and E-selectin) are integrally involved in thrombosis. (ahajournals.org)
  • 2010). ALCAM was first shown as a ligand of CD6 on activated leukocytes (Whitney et al. (atlasgeneticsoncology.org)
  • Briefly, oligomerization on the cell surface and intercellular receptor-ligand binding would synergistically promote ALCAM recruitment and network formation in regions of cell-cell contact. (aacrjournals.org)
  • Here, we exploit a combination of complementary microscopy techniques, including FRET detected by fluorescence lifetime imaging microscopy and single-cell force spectroscopy, and we demonstrate the existence of a preformed ligand-independent supramolecular complex where ALCAM stably interacts with actin by binding to syntenin-1 and ezrin. (amolf.nl)
  • As determined by Western blot and flow cytometry, cells treated with LPS (a TLR4 ligand) and S1P showed significantly enhanced expression of adhesion molecules such as ICAM-1 and E-selectin compared with the effect of either ligand alone. (jimmunol.org)
  • ALCAM is involved in homotypic adhesion, as well as heterotypic adhesion with its natural ligand, CD6. (fishersci.com)
  • A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. (ebi.ac.uk)
  • The activated leukocyte cell adhesion molecule (ALCAM) is dynamically regulated by the actin cytoskeleton. (biologists.org)
  • We demonstrated that stable, homotypic ALCAM-mediated adhesion requires a transient release of ALCAM from the actin cytoskeleton, as induced by partial disruption of the cytoskeleton with cytochalasin D (CytD). (biologists.org)
  • This release from the actin cytoskeleton and enhanced mobility results in the formation of high avidity clusters of ALCAM molecules on the cell surface, which are required for strong adhesive ALCAM-ALCAM interactions. (biologists.org)
  • ALCAM protein is localized to the cell membrane (Bowen et al. (atlasgeneticsoncology.org)
  • The protein loading corresponding to cell lysates was normalized with antiactin. (asm.org)
  • Downstream activation of mitogen-activated protein kinases, Akt, and NF-κB (nuclear factor-κB) pathways resulted in induced expression of ALCAM. (elsevier.com)
  • Activated leukocyte cell adhesion molecule (ALCAM), recombinant mouse protein is supplied as a lyophilized powder. (thermofisher.com)
  • In general, recombinant proteins can also be used as an immunogen, as a protein standard, or in cell biology research applications. (thermofisher.com)
  • He will examine a protein called ALCALM (activated leukocyte cell adhesion molecule), which is important for activating T cells. (eurekalert.org)
  • Results: FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. (iospress.com)
  • Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. (broadinstitute.org)
  • This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. (wikipedia.org)
  • The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. (wikipedia.org)
  • CD88), from the superfamily of G protein-coupled receptors expressed on a variety of cells of myeloid and nonmyeloid origins ( 2 , 3 ). (aacrjournals.org)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • Activated leukocyte cell adhesion molecule (ALCAM), recombinant human protein is supplied as a lyophilized powder. (fishersci.ca)
  • In general, recombinant proteins can be used as protein standard and in cell biology research applications. (fishersci.ca)
  • By contrast, we demonstrated that protein kinase C (PKC) plays a major role in ALCAM-mediated adhesion. (biologists.org)
  • Furthermore, we also demonstrated that this effect of Tat was mediated via activation of mitogen-activated protein kinases and nuclear factor-κB pathways. (jneurosci.org)
  • From maturation to degradation, proteolysis is a ubiquitous posttranslational modification that irreversibly modifies the structure and function of every protein in the cell ( 1 ). (mcponline.org)
  • The IC 50 , together with Akt and HSP70 and 90 protein level data favour VER and TMZ to 17-AAG, however due to the selectivity of VER to cancer cells as a potent antichaperon, it may be more favourable to the standard TMZ. (jcancer.org)
  • 5 Increased numbers of spindle-shaped N -cadherin + CD45 − osteoblastic cells following conditional inactivation of bone morphogenetic protein correlated with an increase in HSC numbers. (bloodjournal.org)
  • In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. (ebi.ac.uk)
  • Intracellular adhesion molecule-1 (ICAM-1) induces firm adhesion of inflammatory cells at the vascular surface [ 10 ]. (hindawi.com)
  • Because C5a-primed polymorphonuclear neutrophils (PMNs) induce hyperpermeability and phosphorylation of adherens junction proteins in endothelial cells ( 8 , 9 ) and in a similar manner C5aAP induces transient hypotension and neutropenia in rats ( 10 ), a hypothesis was put forth that C5aAP interactions with PMNs can initiate a series of events leading to the enhancement of VP. (aacrjournals.org)
  • Although inhibiting HSP90 by the antibiotic geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG), currently in phase III trial ( 5 - 7 ), it causes destabilization of its client proteins and induces cell apoptosis, proteomic analysis showed an elevated HSP70 expression compensating for the inhibition of HSP90 ( 8 ). (jcancer.org)
  • ALCAM-CD6 interaction mediates T-cell activation or proliferation. (atlasgeneticsoncology.org)
  • Proliferation of co-cultured T cells and dendritic cells (DCs) was decreased by the anti-CD6 antibody. (yonsei.ac.kr)
  • Adhesion of ALCAM‑expressing antigen presenting cells and CD6‑expressing T cells stabilizes the early IS, while later it enhances CD3 effects on T cell proliferation, CD25 expression, and Th1 commitment (4, 7, 8). (rndsystems.com)
  • Activated CD8+ T Lymphocytes Inhibit Neural Stem/Progenitor Cell Proliferation: Role of Interferon-Gamma. (stembook.org)
  • MicroRNAs (miRNAs) have important roles in many cellular processes, including cell proliferation, growth and development, and disease control. (bioscirep.org)
  • Natalizumab is a selective adhesion-molecule inhibitor and binds to the alpha4-subunit of human integrins, which is highly expressed on the surface of all leukocytes, with the exception of neutrophils. (intekom.com)
  • 2 Release of platelet activating factor (PAF) and endothelin-1 promotes vasoconstriction, 3 whereas production of von Willebrand factor (vWF), tissue factor (TF), plasminogen activator inhibitor (PAI)-1, and Factor V augment thrombosis. (ahajournals.org)
  • In this study we used HSP90 selective inhibitor 17-AAG and HSP70/90 dual inhibitor, VER155008 (VER) in U87-MG glioma cells. (jcancer.org)
  • ALCAM on thymic epithelia mediates adhesion to CD6 on CD4 + CD8 + T cells (6). (rndsystems.com)
  • Cell surface ligands for CD2 and CD6 have been identified (Fig. 1A ), and there is evidence that CD5 mediates cell-cell contact (reference 11 and references therein). (asm.org)
  • The analysis of signaling pathways revealed the synergistic phosphorylation of ERK upon LPS plus S1P treatment of HUVEC and human aortic endothelial cells and cell-type differences on p38 and NF-κB activation. (jimmunol.org)
  • Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells. (thefreedictionary.com)
  • Subsequent triggering of chemokine receptors through chemokines then activates leukocyte integrins and allows firm adhesion of the cell. (ahajournals.org)
  • The primary aims of the group are to elucidate the evolution and progression of cancer stem cells in primary and metastatic disease, and in so doing identify and validate novel cancer biomarkers and therapeutic targets. (cardiff.ac.uk)
  • The sequence leading to the increased VP appears to be initiated by the interaction of C5aAP with C5a receptor expressed on PMNs followed by binding to endothelial cells of blood vessels. (aacrjournals.org)
  • CD6 antigen is a typeI cell membrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily groupB, predominantly expressed by T cells and a B-cell subset. (biomedcentral.com)
  • Expression of T-cell surface proteins which are involved in regulating antigen-specific T-cell activation is coordinated by the T-cell receptor (TCR). (asm.org)
  • Specifically, natalizumab binds to the alpha4beta1 integrin, blocking the interaction with its cognate receptor, vascular cell adhesion molecule-1 (VCAM-1), and ligands osteopontin, and an alternatively spliced domain of fibronectin, connecting segment-1 (CS-1). (intekom.com)
  • The Activating NKG2C Receptor Is Significantly Reduced in NK Cells after Allogeneic Stem Cell Transplantation in Patients with Severe Graft-versus-Host Disease. (stembook.org)
  • Activation of aryl hydrocarbon receptor by Tranilast, an anti-allergy drug,promotes miR-302 expression and cell reprogramming. (stembook.org)
  • Decrease in intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) expression promotes tumor cell spreading in vivo. (cancerprev.org)
  • Muscle FNDC5 gene expression is induced by peroxisome proliferator-activated receptor-γ co-activator-1α, which is a transcriptional co-activator in the muscle that is up-regulated following 3 weeks of free wheel running in mice [ 12 , 13 ]. (plos.org)
  • In the case of Lewis lung carcinoma (LLC), an additional defect in tumor cell homing to the lungs and a resulting reduction in the number of lung tumor nodules were observed. (uzh.ch)
  • However, since Van Dooremal work in 1873 on tumor cell graft in the eye anterior chamber, it is known that specific sites in the organism display limited immune reactions. (frontiersin.org)
  • Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. (ox.ac.uk)
  • 8 Some ecto-enzymes can physically act as adhesion molecules but most contribute to the adhesion cascade by regulating cell recruitment through their catalytic activity. (ahajournals.org)
  • therefore, the recruitment of proinflammatory cells into the tumor site is an unlikely reason for this augmented effect. (aacrjournals.org)
  • Blockade of the molecular interactions of alpha4beta1 with its targets reduces inflammatory activity present in the brain in MS and inhibits further recruitment of immune cells into inflamed tissue, thus reducing the formation or enlargement of MS lesions. (intekom.com)
  • Thus, the haemodynamic effects of leucocyte recruitment in venules are negligible. (els.net)
  • The above results indicate that ALCAM-ALCAM interactions are crucial to the survival and primary site maintenance of breast cancer cells. (nih.gov)
  • During certain pathological processes, specific genes are activated leading to the change of this immunologically non-reactive tissue into an environment favorable to the development of inflammatory reactions. (frontiersin.org)
  • Therefore the rapid advances in molecular identification of the genes responsible for a given catalytic activity and subsequent generation of gene-deficient mice have only recently allowed detailed analyses of these molecules. (ahajournals.org)
  • In the present study, we analyzed the relationship between level of miR-192 and degree of E. coli resistance using transcription activator-like effector nuclease (TALEN), in vitro bacterial adhesion assays, and target genes research. (bioscirep.org)
  • We found that miR-192 knockout led to enhance the adhesion ability of the E. coli strains F18ab, F18ac and K88ac, meanwhile increase the expression of target genes ( DLG5 and ALCAM ) by qPCR and Western blotting analysis. (bioscirep.org)
  • Novel view on the mechanism of activation of matrix metalloproteinase (mmp): binding of mmp-9 (gelatinase b) to extracellular matrix molecules in vivo and in vitro leads to activation od the enzyme without removal of its n-terminal propeptide. (cancerprev.org)
  • In this study we explored the molecular mechanisms and signaling pathways underlying the cytoskeletal restraints of this homotypic adhesion molecule. (biologists.org)
  • We next investigated transepidermal water loss , clinical score, Th2-immune responses, skin barrier gene expression and T-cell activation using wild-type (WT) and ALCAM deficiency mice . (bvsalud.org)
  • Moreover, immune responses and T cell activation were attenuated in OVA-challenged ALCAM(-/-) mice. (yonsei.ac.kr)
  • Among other regulatory players in the immune response, regulatory T cells (Tregs), particularly so-called natural Tregs, also play a key role in immune homeostasis ( 10 - 13 ). (frontiersin.org)
  • Lupus patients may have increased ALCALM in both their immune systems and their kidneys, and this probably plays a major role in activating the immune system and causing the kidney disease in lupus patients," said Mohan. (eurekalert.org)
  • Membrane proteins that mediate immune cell-cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. (genome.jp)
  • To determine whether JNKs are involved in antiviral T cell immunity, and whether JNK1 and JNK2 bear biological differences, we investigated the immune responses of JNK1-deficient and JNK2-deficient mice to lymphocytic choriomeningitis virus (LCMV). (jove.com)
  • Thus, selectins and their mucin-like ligands mediate the early tethering and rolling of the leukocyte on the endothelial wall. (ahajournals.org)
  • Selectins and their ligands are involved in the rolling and tethering of leukocytes on the vascular wall. (hindawi.com)
  • If the venular endothelial cells express appropriate ligands for microvillus‐associated adhesion receptors, leucocytes become tethered and roll slowly downstream (5). (els.net)
  • Moreover, sALCAM was also shown to inhibit tumor progression in melanoma cells (van Kilsdonk et al. (atlasgeneticsoncology.org)
  • Although ALCAM expression on tumor cells has been linked to tumor invasion and metastatic spread, the contribution of ALCAM expressed in cells forming the tumor stroma to cancer progression has not been investigated. (uzh.ch)
  • The cell surface antigen recognized by monoclonal antibody SB-10 is expressed on human MSCs but is lost during their developmental progression into differentiated phenotypes. (ovid.com)
  • 2019. Importance of activated leukocyte cell adhesion molecule (ALCAM) in prostate cancer progression and metastatic dissemination . (cardiff.ac.uk)
  • Activated Omentum Slows Progression of CKD. (stembook.org)
  • The microplate provided in this kit has been pre-coated with an antibody specific to Activated Leukocyte Cell Adhesion Molecule (ALCAM). (mybiosource.com)
  • Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Activated Leukocyte Cell Adhesion Molecule (ALCAM). (mybiosource.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (fishersci.com)
  • Natalizumab is a recombinant humanised anti-alpha4-integrin antibody produced in a murine cell line by recombinant DNA technology. (intekom.com)
  • From Horwitz Adhesion molecule s involved in leukocyte emigration from vessels during inflammation 2. (picsearch.com)
  • Implicated in Note Entity Recruiting blood leukocytes to the site of inflammation Note E-selectin. (picsearch.com)
  • Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. (nih.gov)
  • Given that TLRs and sphingosine-1-phosphate (S1P) are key players in inflammation, we explored the potential interplay between TLRs and S1P in the adhesion/inflammatory pathways in primary human endothelial cells. (jimmunol.org)
  • Potential for Targeting Myeloid Cells in Controlling CNS Inflammation. (uc.edu)
  • However, in the presence of pro-inflammatory cytokines, VCAM-1 is upregulated on endothelial cells and possibly on glial cells near the sites of inflammation. (intekom.com)
  • Under normal conditions, endothelial cells sustain a vasodilatory and local fibrinolytic state in which coagulation, platelet adhesion, and activation, as well as inflammation and leukocyte activation, are suppressed. (ahajournals.org)
  • Our study demonstrated that irisin significantly reduced atherosclerosis in apolipoprotein E-deficient mice via suppressing ox-LDL-induced cell inflammation and apoptosis, which might have a direct therapeutic effect on atherosclerotic diseases. (plos.org)
  • NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN- γ and CXCR3 chemokines," Blood , vol. 114, no. 3, pp. 667-676, 2009. (hindawi.com)
  • It is involved in cell-cell adhesion through homophilic and heterophilic (to CD6) interactions. (ptglab.com)
  • Maitra B, Szekely E, Gjini K et al (2004) Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. (springer.com)
  • Hare JM, Traverse JH, Henry TD et al (2009) A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. (springer.com)
  • Hu SL, Luo HS, Li JT et al (2010) Functional recovery in acute traumatic spinal cord injury after transplantation of human umbilical cord mesenchymal stem cells. (springer.com)
  • Liang J, Zhang H, Hua B et al (2010) Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. (springer.com)
  • C. Cell lysates and medium samples obtained as for panel B were treated without or with N -glycosidase F as indicated and analyzed by Western blotting as for panel B. D. WT CHO or M2 cells were transiently transfected with the cDNA encoding human Dsg-2. (asm.org)
  • A class of membrane proteins comprising the outer surfaces of cell membranes in the developing nervous system that is thought to be intimately involved in guiding development during embryonic life. (thefreedictionary.com)
  • One of the pivotal mechanisms leading to neuroinflammation associated with human immunodeficiency virus type 1 (HIV-1) infection of the CNS involves breach of the BBB, resulting in influx of inflammatory cells in the CNS with ensuing neurological complications. (jneurosci.org)
  • Furthermore, DYSGT restored the reduction of endothelial nitric oxide synthase (eNOS) expression, leading to the inhibition of intracellular adhesion molecule-1 (ICAM-1) and endothelin-1 (ET-1) expression. (hindawi.com)
  • These proteins regulate antigen-specific responses through cell-cell contact and have substantial cytoplasmic regions which link to intracellular signaling machinery (Fig. 1A ). (asm.org)
  • The temporary reduction in vessel diameter associated with leucocyte adhesion causes a concomitant increase in vascular resistance. (els.net)
  • 1995). Then, it was found on hematopoietic stem cells and myeloid progenitors (Swart, 2002). (atlasgeneticsoncology.org)
  • Graft versus host disease (GvHD) remains a major complication after allogeneic hematopoietic stem cell transplantation and is the main cause of transplant-related mortality. (wiley.com)
  • Both hematopoietic cells and cells that form the hematopoietic stem and progenitor cell niche have been identified as targets of GvHD. (wiley.com)
  • Hematopoietic stem cell transplantation (HSCT) has become an accepted and widely used treatment option for defined malignant and nonmalignant diseases. (wiley.com)
  • Engraftment failure is a rare but life-threatening complication of hematopoietic cell transplantation (HCT). (springer.com)
  • Copelan EA (2006) Hematopoietic stem-cell transplantation. (springer.com)
  • Ho VT, Soiffer RJ (2001) The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. (springer.com)
  • Bone marrow OB ablation leads to reduced quiescence, long-term engraftment, and self-renewal capacity of hematopoietic stem cells. (bloodjournal.org)
  • Hematopoietic stem cells (HSCs) reside in regulatory niches in the bone marrow (BM). (bloodjournal.org)
  • Hematopoietic stem cells (HSCs) are located primarily in the bone marrow (BM) cavity, with HSC niche function residing in nonhematopoietic cells within the BM microenvironment. (bloodjournal.org)
  • ALCAM is expressed on a variety of cell types, including activated T and B cells, monocyte-derived dendritic cells, and thymic epithelial cells. (fishersci.com)
  • Lysates from the indicated cells were analyzed by Western blotting with polyclonal antibodies against the cytoplasmic domain of ADAM17. (asm.org)
  • Cells were washed, lysed, and cell lysates (L) analyzed by Western blotting with antibodies against the extracellular domains of TfnR, ALCAM, and Dsg-2 as indicated. (asm.org)
  • A. Wild-type CHO cells (WT) or M2 mutant cells were lysed and cell lysates analyzed by Western blotting with antibodies against ADAM17 or ADAM10 as indicated. (asm.org)
  • B. Lysates (L) from wild-type CHO cells or M2 cell mutants and medium samples (M) obtained after 48 h of serum starvation were concentrated by WGA-agarose chromatography and analyzed by Western blotting with antibodies against the extracellular domain of ALCAM. (asm.org)
  • Altogether, our results propose a novel biophysical framework to understand the stabilizing role of the ALCAM supramolecular complex engaged to CD6 during dendritic cell-T cell interactions and provide novel information on the molecular players involved in the formation and signaling of the immunological synapse at the dendritic cell side. (amolf.nl)
  • 2019. Incorporating MicroRNA into molecular phenotypes of circulating tumor cells enhances the prognostic accuracy for patients with metastatic breast cancer . (cardiff.ac.uk)
  • ALCAM Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 742 amino acids (28-527a.a.) and having a molecular mass of 83.1kDa (Molecular size on SDS-PAGE will appear at approximately 70-100 kDa). (prospecbio.com)
  • Subcellular localization of activated leukocyte cell adhesion molecule is a molecular predictor of survival in ovarian carcinoma patients. (semanticscholar.org)
  • Ectopic expression of ΔN-ALCAM interferes with intercellular ALCAM network formation ( Fig. 1 B ). Overexpression of ΔN-ALCAM in metastatic melanoma cells not only interfered with endogenous ALCAM but also aggravated the invasive cell behavior ( 18 ). (aacrjournals.org)
  • A. Expression of ADAM17 in parental and stably transfected A431 cells. (asm.org)
  • We successfully suppressed the expression of ALCAM in HECV cells by using the anti-ALCAM transgene. (cf.ac.uk)
  • Moreover, LPS and S1P cooperated to increase the expression of proinflammatory molecules such as IL-6, cyclooxygenase-2, and prostacyclin, as determined by ELISA and Western blot. (jimmunol.org)
  • ALCAM expression has also been used as a marker for the isolation of pluripotent stem cells. (fishersci.com)
  • The aim of this study was to examine ALCAM expression levels in primary breast cancer and distant metastases of the same patient within 29 autopsy cases to better understand the underlying mechanisms of metastases and the role of adhesion molecules in this process. (iospress.com)
  • Bronchoalveolar Lavage Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications. (amedeo.com)
  • CHO-Anti-Human ALCAM F(ab) stable cell line is clonally-derived from a CHO cell line, which has been transfected with an Anti-human ALCAM F(ab) gene to allow expression of the F(ab). (creativebiomart.net)
  • 2 Additionally, in response to endothelial injury, endothelial cells are activated, resulting in increased surface expression of certain cell adhesion molecules (such as P-selectin or E-selectin), promoting the adhesion and activation of leukocytes. (ahajournals.org)
  • Cytokine-regulated expression of E-selectin, intercellular adhesion molecule -1 (ICAM-1) & vascular cell adhesion molecules -1 (VCAM-1) in human intestinal microvascular endothelial cells, J Immunol, 156: 2558-65. (thefreedictionary.com)
  • Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value. (thefreedictionary.com)
  • Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents by blocking E-selectin expression. (cancerprev.org)
  • A TALEN expression vector that specifically recognizes the pig miR-192 was constructed and then monoclonal epithelial cells defective in miR-192 were established. (bioscirep.org)
  • C-Jun NH(2)-terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8(+) T Cell-mediated Antiviral Immunity The Journal of Experimental Medicine. (jove.com)
  • The lacZ reporter cleaves a substrate to produce a small molecule that can be detected in urine. (sciencemag.org)
  • 2012. Identification and characterization of tumor-initiating cells in human primary cutaneous squamous cell carcinoma . (cardiff.ac.uk)
  • It is in a phase II clinical trial (PIICT) for cutaneous T-cell lymphomas treatment. (biomedcentral.com)
  • In MS, lesions are believed to occur when activated T-lymphocytes cross the blood-brain barrier (BBB). (intekom.com)
  • The cerebrovascular unit of the blood-brain barrier (BBB) consists of endothelial cells, astrocytes, and pericytes, which cooperatively maintain a tight barrier that is impermeable to toxic agents, ions, and pathogens, thereby maintaining homeostasis and keeping the brain as an immunoprivileged organ. (jneurosci.org)
  • Spots in red represent proteins with a greater-than-1.5-fold decrease in the conditioned medium of cells treated with BB94. (asm.org)
  • RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. (mdpi.com)
  • The proteome represents the total complement of proteins present in a complex, an organelle, a cell, tissue, or an organism. (springer.com)
  • Identification of proteins from formalin-fixed paraffin-embedded cells by LC-MS/MS. Lab Invest J Tech Methods Pathol . (springer.com)
  • During positive selection, both TCR and a number of T-cell surface proteins, including CD6, CD5, and CD2, are upregulated and remain expressed on mature T cells ( 36 , 40 ). (asm.org)
  • The partially overlapping and opposite effects induced by alternative strategies targeting ALCAM functions collectively attribute an integrative role to ALCAM in orchestrating cell adhesion, growth, invasion, and proteolysis in the tumor tissue microenvironment and disclose a therapeutic potential for sALCAM. (aacrjournals.org)
  • Finally, the levels of ALCAM in HECV cells did not affect the rate of cell growth, in vitro. (cf.ac.uk)
  • Bone Talk: Activated Osteoblasts Promote Lung Cancer Growth. (nih.gov)
  • 2013. CD200-expressing human basal cell carcinoma cells initiate tumor growth . (cardiff.ac.uk)
  • Once cells are thawed, it is important to dilute the cells 1:10 in growth media immediately to reduce the potentially toxic effects of the DMSO preservative on the cells.2. (creativebiomart.net)
  • Add 6.0 to 8.0 ml of complete growth medium and aspirate cells by gently pipetting.3. (creativebiomart.net)
  • ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes. (umassmed.edu)
  • Families of ecto-enzymes involved in leukocyte-endothelial interactions are depicted with representative members from each group. (ahajournals.org)
  • Adhesion and homing molecules on the surface of leucocytes and interacting cells provide mechanical stability and contribute to the specificity of such interactions. (els.net)
  • Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis. (uc.edu)