Activated-Leukocyte Cell Adhesion Molecule

Fetal Proteins

Cell Adhesion Molecules, Neuronal

Lentigo

Cell Adhesion

Cell Adhesion Molecules

Antigens, CD

Neural Cell Adhesion Molecules

Leukocytes

Vascular Cell Adhesion Molecule-1

Neural Cell Adhesion Molecule L1

Intercellular Adhesion Molecule-1

Cell Migration Assays, Leukocyte

ALCAM

CD6

MMP2

Degradomics

Pathophysiology of multiple sclerosis

E-selectin

List of MeSH codes (D12.776.395)

List of MeSH codes (D23)

List of MeSH codes (D12.776.543)

KLF2

Loteprednol

SGEF

Protein C

CEACAM6

ICAM-1

Protease-activated receptor

Kinin

Chemokine receptor

Macrophage-1 antigen

High endothelial venules

Contrast-enhanced ultrasound

Sulfatide

Superantigen

Leukocyte extravasation

Versican

Complement component 5a

Resistin

P-selectin glycoprotein ligand-1

Selectin

CD154

CD34

Galectin-9

PSMB3

Find-me signals

DHRS7B

Catch bond

Cholestasis

Cell polarity

White blood cell

Plasma cell

P-selectin

Diffuse panbronchiolitis

Immunologic adjuvant

Syndecan 1

PSMA3

Haematopoiesis

Neutrophil

Glucocorticoid

Murine respirovirus

PSMB10

Natural killer cell

Paired receptors

Sepsis

Eugene C. Butcher

SEMA4D

Proteases in angiogenesis

Endothelium

Biochemical cascade

ALCAM14

• Activated leukocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis. (nih.gov)
• 1. ALCAM, Activated Leukocyte Cell Adhesion Molecule, in Clinical Gastric Cancer and Patient's Response to Chemotherapies. (nih.gov)
• 2. Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers. (nih.gov)
• 6. Activated leukocyte cell adhesion molecule (ALCAM)/CD166 in pancreatic cancer, a pivotal link to clinical outcome and vascular embolism. (nih.gov)
• 7. Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma. (nih.gov)
• 9. ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression. (nih.gov)
• 10. ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. (nih.gov)
• 11. The role of activated leukocyte cell adhesion molecule (ALCAM) in cancer progression, invasion, metastasis and recurrence: A novel cancer stem cell marker and tumor-specific prognostic marker. (nih.gov)
• 13. Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. (nih.gov)
• 14. Modulation of cell adhesion and migration through regulation of the immunoglobulin superfamily member ALCAM/CD166. (nih.gov)
• 17. Expression of the cell to cell adhesion molecule, ALCAM, in breast cancer patients and the potential link with skeletal metastasis. (nih.gov)
• 18. Prognostic Impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM/CD166) in Infantile Neuroblastoma. (nih.gov)
• ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes. (nih.gov)
• Las interacciones ALCAM-CD6 pueden jugar un papel en la unión de las células T y B a los leucocitos activados. (bvsalud.org)

Inflammation9

• The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. (nih.gov)
• CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation. (biolegend.com)
• o Determination of the types and cellular sources of chemokines and adhesion molecules involved in attracting leukocytes and their attachments at different stages of inflammation. (nih.gov)
• Atherosclerosis is a chronic, inflammatory disease of the vessel wall where triggered immune cells bind to inflamed endothelium, extravasate and sustain local inflammation. (bvsalud.org)
• 2, 3 Inflammation is also implicated in the pathogenesis of acute syndromes, as suggested by histological findings in unstable coronary plaques, 4- 6 evidence of systemic release of thromboxanes and leukotrienes, 7- 9 and the presence of activated circulating leucocytes. (bmj.com)
• A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. (nih.gov)
• As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. (nih.gov)
• HopQ-CEACAM interactions may also utilize T4SS, instead of CagA, to activate NF-κB signaling and trigger inflammation. (ac.ir)
• Summary PSGL-1 is the best-studied selectin ligand and has become a posterchild of versatility in leukocyte adhesion, inflammation and immunology. (elsevierpure.com)

Intercellular adhesion2

• 12. Serum activated leukocyte cell adhesion molecule and intercellular adhesion molecule-1 in patients with gastric cancer: Can they be used as biomarkers? (nih.gov)
• Leukocyte adhesion and extravasation are mediated by adhesion molecules expressed by activated endothelial cells, like intercellular adhesion molecule 1 (ICAM-1). (bvsalud.org)

Vascular6

• VCAM1 is expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. (nih.gov)
• Sickle cell disease is caused by an inherited mutation in the β globin gene that creates hemoglobin S, an abnormal form of hemoglobin which is prone to polymerization when exposed to low oxygen tension which results in sickling of red blood cells, hemolytic anemia, vascular occlusion of small vessels, ischemic tissue and organ injury and recurrent painful crises. (nih.gov)
• Most of the complications of sickle cell disease are due to the vaso-occlusive crises caused the aggregates of sickled red cells, platelets, leukocytes adhering to endothelial cells and causing vascular stasis and ischemic injury to tissues. (nih.gov)
• Furthermore, clarified culture supernatants recovered from C- Fe-treated macrophages raise vascular endothelial cells to an activated state as indicated by the induction of endothelial- leukocyte adhesion molecules ICAM-1, VCAM-1, and E-selectin. (cdc.gov)
• Endothelial dysfunction is now regarded as an regulation, vascular smooth cell proliferation, early pivotal event in atherogenesis 2 and has trans endothelial leukocyte migration, been shown to precede development of clinically thrombosis and thrombolytic balance. (who.int)
• B-CLL cells bound normally to vascular endothelium, but binding to IL-1-activated endothelium was significantly lower than that of normal peripheral blood lymphocytes. (kingston.ac.uk)

Chemokines4

• This activation initiates a cascade of events leading to increased generation of free radicals, activation of nuclear transcription factor-kB (NF-kB), increased transcription of inflammatory cytokines and chemokines, increased expression of adhesion molecules, and increased infiltration of inflammatory cells into the liver. (nih.gov)
• Can blocking the synthesis of chemokines and adhesion molecules arrest the inflammatory process? (nih.gov)
• PSGL-1 also plays a crucial role in T-cell homeostasis by binding to lymphoid chemokines, and can induce tolerance by enhancing the functions of regulatory T cells. (elsevierpure.com)
• Recent findings PSGL-1 was originally described as a leukocyte ligand for P-selectin, but it is actually a ligand for all selectins (P-, L-and E-selectin), binds chemokines, activates integrins and profoundly affects T-cell biology. (elsevierpure.com)

Cytokines8

• Complement plays an important role in the direct defense to pathogens, but can also activate immune cells and the release of pro-inflammatory cytokines. (bvsalud.org)
• 16, 17 The leucocyte count and various inflammatory proteins such as fibrinogen, 18, 19 plasminogen activator inhibitor (PAI-1), 16 von Willebrand factor, 20 albumin, 18 and various cytokines and adhesion molecules have been found to be independently associated with cardiovascular end points. (bmj.com)
• Patterns of adhesion molecule expression and their regulation by cytokines may underly some of the clinical features of this disease. (kingston.ac.uk)
• Other workers and ourselves have found that cell-cell contact is an important signal for the induction of cytokines, and our work has demonstrated that tumour necrosis factor and IL-10 production in rheumatoid arthritis synovial joint cells cultures is dependent on T cell/macrophage interaction. (biomedcentral.com)
• Importantly, we observed that the manner in which T cells were activated influenced the profile of cytokines induced in the monocytes. (biomedcentral.com)
• However, if the T cells were stimulated with a cocktail of cytokines (TNF-α, IL-2 and IL-6) for 8 days (bystander activation), TNF-α production followed but IL-10 production did not [ 11 ]. (biomedcentral.com)
• Fc-induced creation of cytokines by NK cells revealed to rituximab-coated M cell focuses on was also improved by ADAM17 inhibition. (academicediting.org)
• Compact disc56dim NK cells, nevertheless, are cytotoxic without enjoyment potently, mediate antibody reliant mobile cytotoxicity of a disintegrin and metalloprotease-17 (ADCC), and generate cytokines after enjoyment with focus on cells. (academicediting.org)

Selectins1

• Benzene inhalation significantly increased the biomarkers of endothelial activation and injury including endothelial microparticles, activated endothelial microparticles, endothelial progenitor cell microparticles, lung endothelial microparticles, and activated lung and endothelial microparticles while having no effect on circulating levels of endothelial adhesion molecules, endothelial selectins, and biomarkers of angiogenesis. (nih.gov)

Antibodies3

• TotalSeq™-D antibodies are compatible with Mission Bio's Tapestri Single-Cell Sequencing Platform for simultaneous detection of DNA and Protein. (biolegend.com)
• We have also shown that leucocyte adhesion molecule blocking antibodies prevent the recruitment of monocytes, neutrophils, and mast cells into the muscularis and also avert postoperative jejunal muscle dysfunction. (bmj.com)
• Inhibitor studies using antisense and sense oligodeoxynucleotides against mRNAs of iNOS and TNF-alpha, antibodies against adhesion molecules suggested that interactions via CD18 and ICAM-1 leads to activation and mediator production of Kupffer cells cocultured with hepatoma cells. (nii.ac.jp)

ICAM3

• Extracellular adherence protein (Eap) from Staphylococcus aureus binds to a plethora of extracellular matrix proteins, including ICAM-1 and its ligands macrophage-1 antigen (Mac-1, αMß2) and lymphocyte function-associated antigen 1 (LFA-1, αLß2), thereby disrupting the interaction between leukocytes and endothelial cells. (bvsalud.org)
• Kupffer cell-mediated mitochondrial dysfunction in hepatoma cells by production of nitric oxide and the involvement of ICAM-1/LFA-1 molecules in their contact :' Int Immunol. (nii.ac.jp)
• CD18/ICAM-1-dependent nitric oxide production of Kupffer cells as a cause of mitochondrial dysfunction in hepatoma cells : Influence of chronic alcohol feeding. (nii.ac.jp)

Neutrophils2

• o Elucidation of the mechanisms by which neutrophils, monocytes and lymphocytes are activated in hepatic sinusoids, attach to endothelial cells, and pass through the cell lining into the hepatic parenchyma. (nih.gov)
• In developing atherosclerosis, Eap treatment reduced circulating platelet-neutrophil aggregates as well as infiltration of T cells and neutrophils into the growing plaque, accompanied by reduced formation of neutrophil extracellular traps (NETs). (bvsalud.org)

Mediate3

• Sdks mediate cell-cell adhesion with homophilic specificity that underlies their neuronal targeting function. (elifesciences.org)
• Importantly, HIV-infected cell present in all fluid vectorizing the infection, such as semen or cervical vaginal secretion, mediate efficient penile entry where cell-free viruses is not efficient. (nih.gov)
• Mg(2+)-dependent ligand binding does not affect binding of Ca2+ by LFA-1 as measured by NKI-L16 expression, suggesting that Mg2+ binds to a distinct site, and that both cations are important to mediate adhesion. (rupress.org)

Endothelium2

• VCAM1, a single-pass type I membrane protein belonging to the Ig superfamily, is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. (nih.gov)
• TNF-a then induces the expression of leukocyte adhesion molecules upon proximal septal capillary endothelium resulting in the recruitment of inflammatory leukocytes to the site. (cdc.gov)

Receptor4

• This results in increased amount of bacterial endotoxin in hepatic portal system, which activates Kupffer cells of the liver via the CD14 surface receptor. (nih.gov)
• This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. (nih.gov)
• Intro Organic great (NK) cells are described by the appearance of the cell adhesion gun Compact disc56 and absence of the T-cell receptor Compact disc3 (Compact disc56+Compact disc3? (academicediting.org)
• A 30 kDa stimulatory receptor found on resting and activated NATURAL KILLER CELLS. (rush.edu)

Overexpression3

• 4. Overexpression of activated leukocute cell adhesion molecule in gastric cancer is associated with advanced stages and poor prognosis and miR-9 deregulation. (nih.gov)
• Interestingly, in human kidney (HK-2) cells, overexpression of TIMP2 caused ER stress, whereas TIMP2 knockdown attenuated lipopolysaccharide-induced ER stress and apoptosis. (bvsalud.org)
• The overexpression of these molecules may contribute to cancer progression and relapse. (ac.ir)

Interleukin1

• H. pylori may use these HopQ-CEACAM interactions to transfer its CagA oncoprotein into host gastric epithelial cells, which is followed by its phosphorylation and release of interleukin-8. (ac.ir)

Extracellular1

• Transition of leukocyte function-associated antigen-1 (LFA-1), from an inactive into an activate state depends on the presence of extracellular Mg2+ and/or Ca2+ ions. (rupress.org)

Antigen2

• 1997. The Leukocyte Antigen FactsBook Academic Press. (biolegend.com)
• Of all ß2-integrins, T cells, including Treg, only express CD11a/CD18, termed lymphocyte function-associated antigen 1 (LFA-1), on their surface. (bvsalud.org)

Platelets2

• Drugs for sickle cell disease target the prevention of sickle cell formation, but also the subsequent vaso-occlusive crises which is the result of the sickled cells forming aggregates with platelets and leukocytes that adhere to microvascular endothelial cells causing obstruction and local ischemic damage. (nih.gov)
• The Sickled-shaped erythrocytes together with endothelial cells, activated leukocytes, platelets and plasma proteins participate in the multistep vaso-occlusion process (Frenette 2002). (justia.com)

Endothelial cell2

• It mediates leukocyte-endothelial cell adhesion and signal transduction. (nih.gov)
• The presence of preexisting cardiovascular disease increases mortality in patients with COVID-19, and cardiovascular injuries, including myocarditis, cardiac rhythm abnormalities, endothelial cell injury, thrombotic events, and myocardial interstitial fibrosis, are observed in some patients with COVID-19. (jci.org)

Migration5

• 16. Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration. (nih.gov)
• miR-152 Controls Migration and Invasive Potentialby Targeting TGFa in Prostate Cancer Cell Lines. (idrblab.net)
• Appropriate topics for investigation under this PA would include, but are not limited to: o Investigation of the mechanisms by which Kupffer cell-generated inflammatory mediators injure endothelial cells and hepatocytes, and stimulate migration of leukocytes into hepatic parenchyma. (nih.gov)
• ß2-integrins (CD11a-d/CD18) play important roles in the migration of leukocytes into inflamed tissues and cell signaling. (bvsalud.org)
• Up-regulation of MiR-1915 inhibits proliferation, invasion, and migration of Helicobacter pylori-infected gastric cancer cells via targeting RAGE. (ac.ir)

Subsets2

• Thus, CD44 has been reported to be a valuable marker for memory cell subsets. (biolegend.com)
• NK cells can become divided into 2 functionally specific subsets, CD56dim and CD56bright, centered on the cell surface area denseness of Compact disc56.1 Comprising approximately 10% of circulating NK cells, Compact disc56bcorrect NK 169545-27-1 IC50 cells are generally thought to be more proliferative, to possess a higher capability for cytokine creation after enjoyment with IL-18 and IL-12, and to possess poor cytotoxic effector activity at rest. (academicediting.org)

Mediates2

• VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. (nih.gov)
• Structural studies have shown that the transmembrane spike protein (S protein) on the viral surface mediates the entry of SARS-CoV-2 into cells. (jci.org)

Inflammatory3

• In conclusion, in patients who died from SARS-CoV-2 infection complement was activated in both lungs and kidneys indicating that complement might be involved in systemic worsening of the inflammatory response. (bvsalud.org)
• Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs : role of leukocytes. (nii.ac.jp)
• HopQ of H. pylori may interact with CEACAMs of the human gastric cells to induce the development of gastric ulcers and cancers by transferring CagA oncoprotein or inducing activation of T4SS to initiate and maintain inflammatory reactions. (ac.ir)

Mesenchymal Stem2

• Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal lineages. (giostar.com)
• Mesenchymal stem cells (MSCs), also known as multipotent mesenchymal stromal cells, are self-renewing cells which can be found in almost all postnatal organs and tissues [ 3 , 4 ]. (giostar.com)

Immunomodulatory2

• MSCs secrete various immunomodulatory molecules which provide a regenerative microenvironment for a variety of injured tissues or organ to limit the damage and to increase self-regulated tissue regeneration. (giostar.com)
• Here, we focus on T cells, because PSGL-1 was recently described as a major immunomodulatory molecule during viral infection. (elsevierpure.com)

CD442

• As B and T cells become activated or progress to the memory stage, CD44 expression increases from a low or mid level of intensity to high expression levels. (biolegend.com)
• B-CLL cells express high levels of CD44, but expression of the leucocyte integrins was low or absent, while expression of VLA-4 is high. (kingston.ac.uk)

Protein3

• TotalSeq™-D reagents are designed to profile protein expression at single cell level. (biolegend.com)
• We further established the method by which activated NF-kappaB can be visualized (Fluorescence in situ DNA-protein binding assay). (nii.ac.jp)
• Reductive evolution in outer membrane protein biogenesis has not compromised cell surface complexity in Helicobacter pylori. (ac.ir)

Infiltration3

• Histopathologically, it is characterized by liver cell death and infiltration of leukocytes into the hepatic parenchyma. (nih.gov)
• Intervention treatment with Eap of already established plaques did not result in cellular or morphological plaque changes, whereas T cell infiltration was increased and thereby again modulated by Eap. (bvsalud.org)
• Cell surface expression of adhesion molecules in B-cell chronic lymphocytic leukemia (B-CLL) may determine the patterns of dissemination and infiltration. (kingston.ac.uk)

Immunoglobulin2

• Sidekick (Sdk) 1 and 2 are related immunoglobulin superfamily cell adhesion proteins required for appropriate synaptic connections between specific subtypes of retinal neurons. (elifesciences.org)
• Some aspects of this specific connectivity appear to be mediated by recognition molecules of the immunoglobulin superfamily (IgSF). (elifesciences.org)

Contributes1

• 8. Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer. (nih.gov)

Monocytes1

• Thus, if blood T cells were activated with cross-linked anti-CD3, this induced the production of TNF-α and IL-10 in monocytes [ 12 ]. (biomedcentral.com)

CD182

• In humans, loss-of-function mutations in the common subunit CD18 result in leukocyte adhesion deficiency type-1 (LAD-1). (bvsalud.org)
• However, since a constitutive knockout affects all leukocytes and may limit the validity of studies focusing on their cell type-specific role, we established a Treg-specific CD18-floxed mouse strain. (bvsalud.org)

Developing and established1

• We aimed to use Eap to inhibit the interaction of leukocytes with activated endothelial cells in settings of developing and established atherosclerosis in apolipoprotein E (ApoE) deficient mice on high-fat diet. (bvsalud.org)

Epithelial3

• Therefore, we reconstructed urethral mucosa made of fibroblast macrophages overlaid by urethral epithelial cell, and after 17 days, the reconstruction polarized was inserted into microscopic device and inoculated in situ with gag-GFP-HIV-infected T cell producing GFP viruses or with cell-free viruses. (nih.gov)
• Next, by observing live imaging recording was -- we could measure that the time required for the infected T cell to form a productive synapse with epithelial, which lasts approximately a half an hour before the T cell is able to shed virus for another hour and leave its site of (inaudible) as you just show. (nih.gov)
• Human CEACAMs are the cell surface adhesion molecules mainly present on the epithelial cells, endothelial cells and leukocytes. (ac.ir)

Neurons1

• Cell adhesion molecule expressed on activated leukocytes, fibroblasts, and neurons. (nih.gov)

Induces1

• Rat Kupffer cell-derived nitric oxide suppresses proliferation and induces apoptosis of syngeneic hepatoma cells. (nii.ac.jp)

Induce5

• Iron-containing particles have been proposed as a mechanism of introducing unregulated iron into cells, and soluble iron has been shown to induce the expression ofTNF-a in Kupffer cells, which was preceded by an increase in hydroxyl radicals. (cdc.gov)
• To understand how benzene may induce endothelial injury, we exposed human aortic endothelial cells to benzene metabolites. (nih.gov)
• Only Sr2+ ions can replace Ca2+ to express the L16 epitope, and to induce clustering of LFA-1 at the cell surface. (rupress.org)
• Investigations using these techniques revealed that coculture of Kupffer cells and hepatoma cells stimulate productions of NO and TNF-alpha, and these mediators released from Kupffer cells synergistically induce apoptosis of hepatoma cells. (nii.ac.jp)
• Consistent with this, tumor growth was significantly reduced in PSGL-1-deficient mice because of an enhanced number of effector T cells together with reduced levels of inhibitory receptors that induce T-cell exhaustion. (elsevierpure.com)

Expression1

• Ward J, Bonaparte M, Sacks J, Guterman J, Fogli M, Mavilio D, Barker E. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. (rush.edu)

Aggregation1

• Structure-guided mutagenesis results show that this canonical dimer is required for both Sdk-mediated cell aggregation (via trans interactions) and Sdk clustering in isolated cells (via cis interactions). (elifesciences.org)

Stromal cells3

• firstly described a method for MSCs (referred as "stromal cells") isolation from whole bone marrow aspirates based on differential adhesion properties. (giostar.com)
• In late 1980s Owen and Friedenstein reported heterogeneity of the bone marrow stromal cells for the first time [ 7 , 8 ]. (giostar.com)
• Bone marrow stromal cells were further characterized and named mesenchymal stem cell to describe the subtype of marrow stromal cells involved in the process of mesengenesis [ 9 , 10 ]. (giostar.com)

20173

• L-glutamine was approved for use in sickle cell disease in 2017 but has not had widespread use. (nih.gov)
• Cell Host Microbe 2017, 21: 376-389. (ac.ir)
• Abadier, M & Ley, K 2017, ' P-selectin glycoprotein ligand-1 in T cells ', Current Opinion in Hematology , vol. 24, no. 3, pp. 265-273. (elsevierpure.com)

Regulation3

• 19. Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancer. (nih.gov)
• Jewell, A P and Yong, K L (1997) Regulation and function of adhesion molecules in B-cell chronic lymphocytic leukaemia. (kingston.ac.uk)
• We conclude that Ca2+ is involved in avidity regulation of LFA-1 by clustering of LFA-1 molecules at the cell surface, whereas Mg2+ is important in regulation of the affinity of LFA-1 for its ligands. (rupress.org)

Interacts1

• In contrast to other adhesins, HopQ interacts with host cell surface molecules in a glycan independent manner. (ac.ir)

Peripheral5

• o Exploration of the mechanisms of peripheral blood mononuclear cell activation in response to chronic ethanol ingestion. (nih.gov)
• Regulatory T cells (Treg) are essential for the maintenance of peripheral tolerance. (bvsalud.org)
• We have studied T cell/monocyte cognate interactions using cells isolated from the peripheral blood of normal donors. (biomedcentral.com)
• Many Compact disc56bcorrect NK cells in the peripheral bloodstream communicate small to no Compact disc16A. (academicediting.org)
• Components and strategies Donor test remoteness Peripheral bloodstream mononuclear cells (PBMCs) had been separated on a ficoll-hypaque lean from healthful contributor and Compact disc56+Compact disc3? (academicediting.org)

Affects1

• Sickle cell disease affects at least 100,000 Americans and is most common in persons of African descent. (nih.gov)

Ligand3

• Although Mg2+ is directly involved in ligand binding, the role of Ca2+ in LFA-1 mediated adhesion remained obscure. (rupress.org)
• We now demonstrate that binding of Ca2+, but not Mg2+, directly correlates with clustering of LFA-1 molecules at the cell surface of T cells, thereby facilitating LFA-1-ligand interaction. (rupress.org)
• Purpose of review We review P-selectin glycoprotein ligand-1 (PSGL-1) as a selectin and chemokine-binding adhesion molecule. (elsevierpure.com)

Immune4

• However, in critically ill patients with COVID-19 the immune system is inadequately activated leading to severe acute respiratory syndrome (SARS) and acute kidney injury, which is associated with higher mortality. (bvsalud.org)
• Moreover, their ability to modulate immune responses makes them an even more attractive candidate for regenerative medicine as allogeneic transplant of these cells is feasible without a substantial risk of immune rejection. (giostar.com)
• Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
• Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)

Proteins2

• 57 Poly(ADP-ribosyl)ation of nuclear proteins in activated granulocytes was associated with an increase of adhe- sion, clutches, pulleys and other disc-shaped Constructional details of the engine 55 3. (forexsanity.com)
• one type, Compact disc16A, is normally a transmembrane proteins that co-localizes with Fc-RI- and Compact disc3 on NK cells. (academicediting.org)

Reactive1

• The activation of XO and reduced Tetrahydrobiopterin (BH 4 ) levels in endothelial cells leads to increased reactive oxygen species (ROS) formation, which in turn leads to endothelial nitric oxide synthase (eNOS) uncoupling and further production of superoxide (Thomas, et al 2010). (justia.com)

Chronic3

• A non-pharmacologic approach to management of sickle cell anemia is chronic transfusions to raise the hemoglobin level and provide normal hemoglobin and its oxygen carrying ability. (nih.gov)
• In addition, chronic therapy with hydroxyurea has a beneficial effect in sickle cell disease by increasing fetal hemoglobin synthesis (hemoglobin F) which provides a proportion of normal oxygen carrying hemoglobin. (nih.gov)
• Chronic therapy with hydroxyurea can decrease sickling and increase hemoglobin levels, with a decrease in vaso-occlusive crises and improvement in general well-being in individuals with sickle cell disease. (nih.gov)

Biology2

• The field of the present invention includes at least biology, cell biology, and medicine. (justia.com)
• The direct involvement of PSGL-1 in T-cell biology suggests that it might be a drug target. (elsevierpure.com)

Lymphoid1

• However, the uncertainty or fluctuation of single-cell transcriptome dynamics during differentiation was not considered, and the dendritic cell (DC) pathway in the lymphoid context remains unclear. (bvsalud.org)

Tissue5

• The tissue levels of endogenous antioxidants are often deficient in sickle cell disease and can be increased by L-glutamine intake. (nih.gov)
• Stem cells are immature tissue precursor cells which are able to self-renew and differentiate into multiple cell lineages [ 1 , 2 ]. (giostar.com)
• And using ex vivo explant infection as well as reconstruction infection -- mucosal reconstruction infection, we have shown that HIV can penetrate by two pathway to penetrate the penile tissue, first through the foreskin where HIV target Langerhans cells trans-infect CD4 T cell. (nih.gov)
• When the reconstruction was observed by spinning disc live imaging, as you can see here, T cell adhere to the surface of the epithelium, forming virology synapse able to shed burst of viral particle that will penetrate inside the tissue. (nih.gov)
• Histological studies of synovium in RA have indicated that this tissue is very cellular, and that several different cell types including macrophages and T cells are in close proximity [ 6 ]. (biomedcentral.com)

Biol2

• DNA Cell Biol. (idrblab.net)
• J Cell Biol (1994) 124 (6): 1061-1070. (rupress.org)

Sickle cell di8

• Drugs for sickle cell disease include agents that increase fetal hemoglobin, which has a higher affinity for oxygen and can decrease sickling and agents that act downstream from sickling in preventing the microvascular occlusions due to the sickled red cells by inhibition of hemoglobin S polymerase, decreasing oxidative stress, and lessening of sickle cell adhesion to endothelial cells. (nih.gov)
• Medications specifically approved for use in sickle cell disease include hydroxyurea, L-glutamine, voxelotor and crizanlizumab all of which act on a different target in the pathway of vaso-occlusive crises. (nih.gov)
• Hydroxyurea was approved for use in sickle cell disease in 1998 and is considered a first line therapy in management of this disease. (nih.gov)
• L-glutamine appears to act in decreasing painful crises in sickle cell disease by increasing levels of nicotinamide adenine dinucleotide (NAD) and glutathione, essential molecules in intracellular oxidative-reductive balance and metabolism. (nih.gov)
• The present invention includes embodiments for treatment and/or prevention of sickle cell disease that employ Hydroxyfasudil or Isocoronarin D alone or either in conjunction with each other or an inducer of HbF production. (justia.com)
• In particular aspects, the field of the present invention includes treatment and/or prevention of a blood disorder, such as sickle cell disease. (justia.com)
• Sickle cell disease (SCD) is the most common life-threatening monogenic disorder in the world with statistics indicating that approximately 80% (230,000) of children affected globally are born in sub-Saharan Africa (Modell and Darlison 2008). (justia.com)
• Sickle cell disease (SCD) can arise from a single point mutation that causes erythrocyte deformation or sickle-shaped erythrocytes (Ingram 1957). (justia.com)

Promotes1

• Absence of PSGL-1 promotes effector CD4 and CD8 T-cell differentiation and prevents T-cell exhaustion. (elsevierpure.com)

Proliferation1

• MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha. (idrblab.net)

Mediators1

• The "response to injury" hypothesis postulates that endothelial dysfunction represents the initial step of atherogenesis and can be induced by haemodynamic forces, by a variety of vasoactive substances, by mediators from blood cells, and directly from risk factors for atherosclerosis. (bmj.com)

Infection2

• Downregulated regulatory T cell function is associated with increased peptic ulcer in Helicobacter pylori-infection. (ac.ir)
• It has been shown recently that PSGL-1 can modulate T cells during viral infection by acting as a negative regulator for T-cell functions. (elsevierpure.com)

Surface4

• We noticed that weak binding of Ca2+ is associated with a dispersed LFA-1 surface distribution on T cells and with non-responsiveness of these cells to stimuli known to activate LFA-1. (rupress.org)
• Our results demonstrate that over-activation of ADAM17 in NK cells may become harmful to their effector features by down-regulating surface area appearance of Compact disc16 and Compact disc62L. (academicediting.org)
• 12-14 This procedure might end up being essential for speedy modulation of the surface area thickness of Compact disc16A, and in convert the account activation effector and position function of NK cells. (academicediting.org)
• Ectodomain getting rid of is normally a proteolytic procedure that adjusts the cell surface area thickness of several cell surface area elements on leukocytes. (academicediting.org)

Hemoglobin2

• The most common type of SCD is sickle cell anemia (SCA) (also referred to as HbSS or SS disease or hemoglobin S) in which there is homozygosity for the mutation that causes HbS. (justia.com)
• This process of self-assembly (polymerization) generates the sickled hemoglobin molecule (HbS) that damages the membrane and cytoskeleton of the erythrocyte. (justia.com)

Mononuclear cells1

• We have found that TNF-α production in RA synovium is T-cell dependent, as removal of CD3-positive T cells from RA synovial mononuclear cells resulted in significant reduced macrophage TNF-α production [ 7 ]. (biomedcentral.com)

Macrophages2

• Second, HIV penetrates the urethra, which will be one topic of today, and target directly macrophages, but not T cell. (nih.gov)
• This may suggest that contact signals between macrophages and T cells could be of importance in vivo in modulating macrophage function. (biomedcentral.com)