Activated-Leukocyte Cell Adhesion Molecule: Cell adhesion molecule expressed on activated leukocytes, fibroblasts, and neurons. It is a ligand for CD6. ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes.Fetal Proteins: Proteins that are preferentially expressed or upregulated during FETAL DEVELOPMENT.Cell Adhesion Molecules, Neuronal: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.Lentigo: Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).Cell Adhesion: Adherence of cells to surfaces or to other cells.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Neural Cell Adhesion Molecules: Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Vascular Cell Adhesion Molecule-1: Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)Neural Cell Adhesion Molecule L1: A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.Intercellular Adhesion Molecule-1: A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.Cell Migration Assays, Leukocyte: Assays that measure the rate of migration of LEUKOCYTES. They may involve a variety of techniques such as measuring the movement of leukocytes through substrates such as AGAROSE gels or the rate of exit of cells from a glass capillary.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Hemostatic Disorders: Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood fluidity, and BLOOD COAGULATION. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the VASCULAR ENDOTHELIUM, the plasma proteins (including BLOOD COAGULATION FACTORS), and PLATELETS.Hemorrhagic Disorders: Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Hemostasis: The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.Hemostatics: Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Amine Oxidase (Copper-Containing): A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.5'-Nucleotidase: A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.Extravasation of Diagnostic and Therapeutic Materials: The escape of diagnostic or therapeutic material from the vessel into which it is introduced into the surrounding tissue or body cavity.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.WalesNobel PrizeFellowships and Scholarships: Stipends or grants-in-aid granted by foundations or institutions to individuals for study.Hepatocyte Growth Factor: Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).Paeonia: A plant genus of the family Paeoniaceae, order Dilleniales, subclass Dilleniidae, class Magnoliopsida. These perennial herbs are up to 2 m (6') tall. Leaves are alternate and are divided into three lobes, each lobe being further divided into three smaller lobes. The large flowers are symmetrical, bisexual, have 5 sepals, 5 petals (sometimes 10), and many stamens.Receptor-Like Protein Tyrosine Phosphatases, Class 3: A subclass of receptor-like protein tryosine phosphatases that contain a single cytosolic protein tyrosine phosphate domain and multiple extracellular fibronectin III-like domains.Exosomes: A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Receptors, Scavenger: A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Stem Cell Niche: A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Distribution and function of the adhesion molecule BEN during rat development. (1/109)

It is well established that the notochord influences the development of adjacent neural and mesodermal tissue. Involvement of the notochord in the differentiation of the dorsal pancreas has been demonstrated. However, our knowledge of the signals involved in pancreatic development is still incomplete. In order to identify proteins potentially implicated during pancreatic differentiation, we raised and characterized monoclonal antibodies against previously established embryonic pancreatic ductal epithelial cell lines (BUD and RED). Using the MAb 2117, the cell surface antigen 2117 (Ag 2117) was cloned. The predicted sequence for Ag 2117 is the rat homologue of BEN. Initially reported as a protein expressed on epithelial cells of the chicken bursa of Fabricius, BEN is expressed in a variety of tissues during development and described as a marker for the developing central and peripheral chicken nervous systems. A role has been suggested for BEN in the adhesion of stem cells and progenitor cells to the blood-forming tissue microenvironment. In this study, we demonstrate that BEN, initially expressed exclusively in the notochord during the early development of rat, is implicated in pancreatic development. We show that Ag 2117 regulates the pancreatic epithelial cell growth through the ras and Jun kinase pathways. In addition, we demonstrate that Ag 2117 is able to regulate the expression of the transcription factor PDX1, required for insulin gene expression, in embryonic pancreas organ cultures.  (+info)

Extracellular matrix-associated protein Sc1 is not essential for mouse development. (2/109)

Sc1 is an extracellular matrix-associated protein whose function is unknown. During early embryonic development, Sc1 is widely expressed, and from embryonic day 12 (E12), Sc1 is expressed primarily in the developing nervous system. This switch in Sc1 expression at E12 suggests an importance for nervous-system development. To gain insight into Sc1 function, we used gene targeting to inactivate mouse Sc1. The Sc1-null mice showed no obvious deficits in any organs. These mice were born at the expected ratios, were fertile, and had no obvious histological abnormalities, and their long-term survival did not differ from littermate controls. Therefore, the function of Sc1 during development is not critical or, in its absence, is subserved by another protein.  (+info)

Evidence for the expression of a second CD6 ligand by synovial fibroblasts. (3/109)

OBJECTIVE: CD6, a cell surface glycoprotein expressed primarily on T cells, may function as a costimulatory molecule and may play a role in autoreactive immune responses. Recently, a CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule [ALCAM]) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. However, the results of functional studies have suggested the existence of a second CD6 ligand. The present study was undertaken to seek evidence for a second CD6 ligand on cultured synovial fibroblasts. METHODS: Flow cytometric and biochemical techniques were applied, using anti-CD166 monoclonal antibody (mAb) and a recombinant CD6 fusion protein, to determine whether cultured synovial fibroblasts and other cell types expressed a non-ALCAM CD6 ligand. RESULTS: CD14- fibroblastic synoviocytes showed greater binding of a recombinant CD6 fusion protein than of anti-ALCAM mAb. With interferon-gamma treatment of synovial fibroblasts, binding of both reagents increased, but this was more marked for binding of CD6 fusion protein. Exposure of synovial fibroblasts to other cytokines or to the superantigen staphylococcal enterotoxin A also regulated binding of CD6 fusion protein and anti-ALCAM mAb in a discordant manner. Immunoprecipitation of proteins from membrane extracts of synovial fibroblasts with a CD6-Ig fusion protein revealed a novel 130-kd band distinct from CD166; an identical molecule was also precipitated from membranes of HBL-100 tumor cells. CONCLUSION: Taken together with previous data regarding CD6 and CD166 function, the present findings strongly suggest the existence of a second CD6 ligand distinct from CD166, which can be expressed by synovial fibroblasts as well as other cells.  (+info)

Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin. (4/109)

Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions reveals that ALCAM expression correlates with melanoma progression. Most nevi (34/38) and all thin melanomas studied (Clark levels I and II) did not express ALCAM. In contrast, immunoreactivity was detected in the invasive, vertical growth phase of 2 of the 13 Clark level III lesions tested. The fraction of positive lesions further increased in Clark level IV (13/19) and in Clark level V (4/4) lesions. ALCAM expression was exclusively detectable in the vertical growth phase of the primary tumor. In melanoma metastases, approximately half of the lesions tested (13/28) were ALCAM positive. According to the Breslow-thickness, ALCAM expression was observed in less than 10% of the lesions that were thinner than 1.5 mm and in over 70% of the lesions that were thicker than 1.5 mm. Our results strongly suggest that ALCAM plays an important role in melanocytic tumor progression and depict it as a new molecular marker for neoplastic progression of primary human melanoma.  (+info)

DM-GRASP is necessary for nonradial cell migration during chick diencephalic development. (5/109)

Cell migration is fundamental to normal CNS development. Radial migration, along radial glial fibers, has been the principal pathway studied, however, nonradial or tangential cell migration has increasingly been identified at all levels of the CNS. Receptors, cell adhesion molecules, and extracellular matrix molecules have all been shown to participate in radial cell migration. In contrast, the molecular basis of nonradial cell migration has only recently begun to be elucidated. Using replication defective retroviral vectors we have determined the location and time when nonradial cell migration begins in the developing chick diencephalon. We have identified three molecules that are expressed in spatially and temporally restricted domains that are consistent with them playing a role in nonradial cell migration. One of these molecules, DM-GRASP, a transmembrane protein with five extracellular Ig domains, is expressed on the nonradially migrating cells in addition to axons. To test the hypothesis that DM-GRASP participates in guiding nonradial cell migration, we injected a replication-defective retroviral vector used for lineage tracing followed by a DM-GRASP blocking antibody. Embryos injected with the blocking antibody showed a near complete block in nonradial cell migration specifically where DM-GRASP is expressed. Furthermore, morphological analyses revealed disruption of the normal architecture of the diencephalon indicating nonradial cell migration is necessary for normal morphological development of the brain. Our data indicate that DM-GRASP is necessary for nonradial cell migration in the chick diencephalon and have provided a system to further explore the function of nonradial cell migration during CNS development.  (+info)

Dynamic regulation of activated leukocyte cell adhesion molecule-mediated homotypic cell adhesion through the actin cytoskeleton. (6/109)

Restricted expression of activated leukocyte cell adhesion molecule (ALCAM) by hematopoietic cells suggests an important role in the immune system and hematopoiesis. To get insight into the mechanisms that control ALCAM-mediated adhesion we have investigated homotypic ALCAM-ALCAM interactions. Here, we demonstrate that the cytoskeleton regulates ALCAM-mediated cell adhesion because inhibition of actin polymerization by cytochalasin D (CytD) strongly induces homotypic ALCAM-ALCAM interactions. This induction of cell adhesion is likely due to clustering of ALCAM at the cell surface, which is observed after CytD treatment. Single-particle tracking demonstrated that the lateral mobility of ALCAM in the cell membrane is increased 30-fold after CytD treatment. In contrast, both surface distribution and adhesion of a glycosylphosphatidylinositol (GPI)-anchored ALCAM mutant are insensitive to CytD, despite the increase in lateral mobility of GPI-ALCAM upon CytD treatment. This demonstrates that clustering of ALCAM is essential for cell adhesion, whereas enhanced diffusion of ALCAM alone is not sufficient for cluster formation. In addition, upon ligand binding, both free diffusion and the freely dragged distance of wild-type ALCAM, but not of GPI-ALCAM, are reduced over time, suggesting strengthening of the cytoskeleton linkage. From these findings we conclude that activation of ALCAM-mediated adhesion is dynamically regulated through actin cytoskeleton-dependent clustering.  (+info)

Expression of DM-GRASP/BEN in the developing mouse spinal cord and various epithelia. (7/109)

The expression pattern of the immunoglobulin DM-GRASP/BEN gene was studied in the mouse embryo using in situ hybridization. DM-GRASP/BEN is expressed in the spinal cord in a subset of motoneurons expressing Islet-1, and non homogeneously in the dorsal root ganglia (DRG). In contrast, it's expression is homogeneous in the vestibulo-cochlear and trigemminal ganglia. DM-GRASP/BEN is also expressed in various epithelia of ectodermal or endodermal origin like the nasal, buccopharyngal and lung epithelia. In upper lip, DM-GRASP/BEN transcripts are present in the epidermal cells of the developing hair vibrissa follicles. First detected in the hair placode, DM-GRASP/BEN expression is localized in the central cells of the epithelial hair peg and then in a thin layer of cells crushed against the outer root sheath by the outgrowth of the hair shaft.  (+info)

A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells. (8/109)

In lower vertebrates, retinal ganglion cells (RGCs) can regenerate their axons and reestablish functional connections after optic nerve injury. We show here that in goldfish RGCs, the effects of several trophic factors converge on a purine-sensitive signaling mechanism that controls axonal outgrowth and the expression of multiple growth-associated proteins. In culture, goldfish RGCs regenerate their axons in response to two molecules secreted by optic nerve glia, axogenesis factor-1 (AF-1) and AF-2, along with ciliary neurotrophic factor. The purine analog 6-thioguanine (6-TG) blocked outgrowth induced by each of these factors. Previous studies in PC12 cells have shown that the effects of 6-TG on neurite outgrowth may be mediated via inhibition of a 47 kDa protein kinase. Growth factor-induced axogenesis in RGCs was accompanied by many of the molecular changes that characterize regenerative growth in vivo, e.g. , increased expression of GAP-43 and certain cell surface glycoproteins. 6-TG inhibited all of these changes but not those associated with axotomy per se, e.g., induction of jun family transcription factors, nor did it affect cell survival. Additional studies using RGCs from transgenic zebrafish showed that expression of Talpha-1 tubulin is likewise stimulated by AF-1 and blocked by 6-TG. The purine nucleoside inosine had effects opposite to those of 6-TG. Inosine stimulated outgrowth and the characteristic pattern of molecular changes in RGCs and competitively reversed the inhibitory effects of 6-TG. We conclude that axon regeneration and the underlying program of gene expression in goldfish RGCs are mediated via a common, purine-sensitive pathway.  (+info)

An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in various cancer types. In some cancers ALCAM has a prognostic value or is predictive for the benefit of therapeutic interventions. To date there are no data on the role of ALCAM in cervical cancer available. In this study, ALCAM expression was analysed by immunohistochemistry (IHC) in tissue samples of 233 patients with cervical cancer, among them 178 with complete follow-up information. In addition, soluble (s-)ALCAM was measured in sera of a subset of the included patients (n = 55) by enzyme-linked immunosorbent assay (ELISA). ALCAM overexpression was detected (immunoreactive score (IRS) 2-12) in 58.4% of the cervical cancer samples. The normal ectocervical or endocervical epithelium showed no ALCAM reactivity. In untreated patients, ALCAM overexpression in tumor tissue tended to be associated with shorter cancer-specific survival (CSS) and disease-free survival (DFS). Patients,
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ABIN888844 from antibodies-online
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Our purpose was assess the impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM) on Human Vascular Endothelial Cells (HECV), these cell are important in angiogenesis and hence wound healing. HECV line positive for ALCAM were used. Anti-ALCAM transgenes were constructed based on the secondary structure of the ALCAM mRAN. After transfection of HECV cells with the transgene and control vectors, the following cell sublines were created; a control (HECVpEF) endothelial cell line and a ALCAM-knockdown (HECVALCAM/KD) cell line. We then assessed the impact of ALCAM on cellular migration of the endothelial cells by way of electric wounding using Electrical Cell Impedence Sensing (ECIS) zy model. We successfully suppressed the expression of ALCAM in HECV cells by using the anti-ALCAM transgene. HECV rapidly migrated after wounding. It recovered at a rapid pace (0.57/min). Interestingly, after losing ALCAM transcript, the HECVALCAM/KD cells migrated at a substantially reduced rate. Finally, the ...
ALCAM - ALCAM (untagged)-Human activated leukocyte cell adhesion molecule (ALCAM) available for purchase from OriGene - Your Gene Company.
CD6 antigen is a typeI cell membrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily groupB, predominantly expressed by T cells and a B-cell subset. CD6 binds activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily (IgSF). ALCAM is expressed on activated T cells, B cells, monocytes, skin fibroblasts, keratinocytes and rheumatoid arthritis synovium, and mediates homophilic and heterophilic adhesion. CD6-ligand interaction has been implicated in cell adhesion, T-cell maturation and regulation of activation, constituting an uncommon type of protein-protein superfamilies interaction. The ior t1 is a murine IgG2a mAb recognizing a different epitope compared to other anti-CD6 mAbs. It is in a phase II clinical trial (PIICT) for cutaneous T-cell lymphomas treatment. Recently, we reported its intravenous therapeutic effect in a Psoriasis vulgaris patient. A PIICT was performed in 18 rheumatoid arthritis patients. ...
CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene. This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. Certain alleles of this gene may be associated with susceptibility to multiple sclerosis. Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000013725 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024670 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". "Entrez Gene: CD6 CD6 molecule". Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213-20. ...
Several laboratories have begun to characterize the interactions between MSCs and cells of the immune system. hMSCs have a number of surface molecules that would predict interaction with T cells. MHC I, Thy-1 (CD90), vascular cell adhesion molecule (CD106, VCAM), intercellular adhesion molecule 1 (ICAM-1) and ICAM-2, activated leukocyte cell adhesion molecule (CD166, ALCAM), lymphocyte functional antigen-3, and integrins α1 to α3, α5, α6, β1, β3, and β4 (CD49 a, b, c, e, and f) are surface molecules expressed on hMSCs that have cognate ligands on T cells.21,28,50,51 Additionally, although not expressed at appreciable levels on hMSCs, MHC II expression is upregulated by incubating the cells with interferon-γ. However, the hMSCs lack the B7 costimulatory molecules CD80 and CD86, and these are not expressed after interferon treatment.52,53. Intuitively, one might expect allogeneic MSCs (allo-MSCs) would stimulate T cell proliferation and that donor MSCs would be recognized by responder T ...
Clone REA442 recognizes the human CD166 antigen, a single-pass type I membrane protein also known as activated leukocyte cell adhesion molecule (ALCAM). CD166, a member of the immunoglobulin superfamily and a ligand for the lymphocyte antigen CD6, mediates homophilic and heterophilic adhesion. It is expressed on activated leukocytes T cells, B cells, monocytes, hematopoietic stem cells (HSCs), metastasizing melanoma, neuronal cells, endothelial cells, hematopoiesis-supporting osteoblastic cell lines, and mesenchymal stem cells (MSCs). CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human HSCs and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate. Additional information: Clone REA442 displays negligible binding to Fc receptors. - Sverige
CD166 antibody [8E12C7] (activated leukocyte cell adhesion molecule) for ELISA, FACS, ICC/IF, IHC-P, WB. Anti-CD166 mAb (GTX60782) is tested in Human samples. 100% Ab-Assurance.
CD166 antibody, N-term (activated leukocyte cell adhesion molecule) for FACS, IHC-P, WB. Anti-CD166 pAb (GTX81961) is tested in Human samples. 100% Ab-Assurance.
A and an apparatus method for quickly and easily identifying the five basic components of leukocyte cells: basophils, eosinophils, neutrophils, monocytes and lymphocytes is disclosed. The method measures the size of each of the cells. Computation of the quantile feature of the cells and their color is then made. BA and EO cells are differentiated from LY and MO and Ne cells using the present method. BA and EO cells can also be differentiated from LY, MO, and Ne cells using methods of the prior art. Once BA and EO cells have been differentiated from the five leukocyte cells, LY cells can be differentiated from MO and NE cells based upon the size of the LY cells. The average color intensity of the LY cells determined is then used as the threshold to differentiate MO cells from NE cells.
Reactivity: Chicken, Cow, Human and more. Compare 11 different LECT1 ELISA Kits & buy the right one directly at antibodies-online.com!
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of ...
CD166 (ALCAM), APC, clone: eBioALC48, eBioscience™ 25μg; APC CD166 (ALCAM), APC, clone: eBioALC48, eBioscience™ Primary Antibodies CD151 to CD200
Preclinical DSS IBD Model. Inflammation: IBD, Crohns & Colitis. Pathology involves innate inflammation to study leukocyte cells and more.
CHO-Anti-Human ALCAM F(ab) stable cell line is clonally-derived from a CHO cell line, which has been transfected with an Anti-human ALCAM F(ab) gene to allow expression of the F(ab). It is an example of a cell line transfected using our proprietary CBTGS gene screening and amplification system.
Cell adhesion molecule expressed on activated leukocytes, fibroblasts, and neurons. It is a ligand for CD6. ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes. . ...
Human ALCAM full-length ORF ( AAH57809.1, 1 a.a. - 133 a.a.) recombinant protein with GST-tag at N-terminal. (H00000214-P01) - Products - Abnova
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CD166 (ALCAM) Mouse anti-Human, PerCP-eFluor 710, Clone: 3A6, eBioscience™ 25 tests; PerCP-eFluor 710 CD166 (ALCAM) Mouse anti-Human, PerCP-eFluor 710, Clone:...
TY - JOUR. T1 - Regulation of human LZIP expression by NF-κB and its involvement in monocyte cell migration induced by Lkn-1. AU - Jang, Sung Wuk. AU - Yoon, Suk Kim. AU - Yoon, Rim Kim. AU - Ho, Joong Sung. AU - Ko, Je Sang. PY - 2007/4/13. Y1 - 2007/4/13. N2 - Human LZIP is a transcription factor that is involved in leukocyte cell mobility. Expression of LZIP is known to differentially regulate monocyte cell migration induced by CCR1-dependent chemokines. However, its transcriptional regulation has not been characterized. Our results indicate that Lkn-1 induces LZIP expression in a time- and dose-dependent manner, and the induction of LZIP shows an immediate early response to Lkn-1. We identified and cloned ∼1.4 kb of the LZIP promoter from a human genomic DNA. To identify regulatory elements controlling restricted expression of LZIP, deletion mutants were constructed from the 1469-bp LZIP promoter region (-1219/+251) linked to the luciferase reporter gene. Maximal promoter activity was ...
ITGA4 Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB ...
exchanger or the BSC-1 and BSC-2 isoforms of the Na+/K+/2Cl−cotransporter, could also be involved in RTC apoptosis, by impeding intracellular volume expansion. However, prominent functions for these proteins in proximal RTC apoptosis are unlikely, since none are abundantly expressed in the proximal tubule (1,15, 18).. In addition to cell shrinkage, RTC NHE1 degradation was also associated with intracellular acidification (16). The data are in agreement with studies in leukocyte cell lines, which demonstrate that apoptosis is preceded by decreased pHi (16,27, 36). Importantly, NHE1 stimulation prevented intracellular acidification and abrogated apoptosis (16, 36), indicating NHE1 activation opposes apoptosis. Rich et al. (40) demonstrated that human leukemia cells exhibit a significantly higher pHi compared with normal leukocyte lineage cells. Moreover, decreased pHi was associated with increased apoptosis, which was exacerbated by exposure to the NHE1 inhibitor HMA. Barrière et al. (2) ...
Citáty Ben Bernanke. Přehled nejoblíbenějších a nejznámějších citátů. Ben Shalom Bernanke je americký ekonom, bývalý předseda rady guvernérů Federál…
Boy Meets World fans, meet the best news youll hear all day. TVLine has learned exclusively that Ben Savage and Danielle Fishel have officially signed on to reprise their roles as Cory Matthews and Topanga Lawrence in the red-hot Disney Channel pilot Girl Meets World. The potential sequel…
Proof that the remaining 10% is worth drowning for here. These are recommendations made by Tropers for Ben Drowned fanfics, all of which have to be signed …
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Taylor, Ben I_BEN/0002 -- Discover Life
Fanpop community fan club for Ben 10 fans to share, discover content and connect with other fans of Ben 10. Find Ben 10 videos, photos, wallpapers, forums, polls, news and more.
Hall of Fame running back Jerome Bettis on whether or not Ben Roethlisberger is ready to retire and if Mike Tomlin gets enough credit for the Steelers success.
The doctor who performed a procedure on Ben Roethlisberger's meniscus told the Steelers that the quarterback could miss 4-6 weeks, sources told ESPN.
SiyahMaviKýrmýzýSarý MÜSLÜMAN KADIN KABÝNE BAKANI: MÜSLÜMANLARA KARÞI ÖN YARGI YAYGIN HALDE Ha be ri say fa 16 de YÖNETMEN MESUT UAKAN: BEN DE SAÝD NURSÎ FÝLMÝ EKMEK ÝSTERÝM Ha be ri say fa 16 da YGER
Deoxyribonuclease-1-like 2 is an enzyme that in humans is encoded by the DNASE1L2 gene. Model organisms have been used in the study of DNASE1L2 function. A conditional knockout mouse line, called Dnase1l2tm1(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice and eight significant abnormalities were observed. Homozygous mutant animals had a decreased body weight, grip strength and bone mineral content; a kinked tail, abnormal indirect calorimetry and femur/tibia morphology. Females also had an increased blood urea nitrogen level while males had a decreased leukocyte cell number. GRCh38: Ensembl release 89: ENSG00000167968 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024136 - ...
Allergic to peanuts? Chances are you avoid all tree nuts. But new research suggests that this step is not always necessary, and might actually be nutty!
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
25 February 2018... Ben Roethlisberger news, gossip, photos of Ben Roethlisberger, biography, Ben Roethlisberger girlfriend list 2016. Relationship history. Ben Roethlisberger relationship list. Ben Roethlisberger dating history, 2018, 2017, list of Ben Roethlisberger relationships.
Watch Ben 10 - Season 2, Episode 12 - Dr. Animo and the Mutant Ray: The Tennysons arrive at a swamp, where the festivities of Gatorfest start first thing the next day. Gwen finds Ben playi...
Ben Doron is the author of this article in the Journal of Visualized Experiments: Tractable Mammalian Cell Infections with Protozoan-primed Bacteria
Actor Ben Affleck opened up about his recovery from alcoholism and how it affected his relationships with his ex-wife and his children.
Figure 2.79 - Selectin bound to a sugar Wikipedia. Selectins (Figure 2.79) are cell adhesion glycoproteins that bind to sugar molecules. As such, they are a type of lectin - proteins that bind sugar polymers (see HERE also). All selectins have an N-terminal calcium-dependent lectin domain, a single transmembrane domain, and an intracellular cytoplasmic tail.. There are three different types of selectins, 1) E-selectin (endothelial); 2) L (lymphocytic; and 3) P (platelets and endothelial cells. Selectins function in lymphocyte homing (adhesion of blood lymphocytes to cells in lymphoid organs), in inflammation processes, and in cancer metastasis. Near the site of inflammation, P-selectin on the surface of blood capillary cells interacts with glycoproteins on leukocyte cell surfaces. This has the effect of slowing the movement of the leukocyte. At the target site of inflammation, E- selectin on the endothelial cells of the blood vessel and L-selectin on the surface of the leukocyte bind to their ...
Ashlens POV* Today Im 12, but Im sad... Why?? Because This was the age and day my brother die on my birthday. *********7 years ago************ Brother lets go please!! I said as we walk to the lake. Fine! You win!! Ben said, Its strange that are family never invites use to go anywhere Ben mumbles to himself. *******few minutes later******** As we arrived at the pond ( oh I forgot to tell u that they have swimming suits on) I saw my father, uncle, and our two cousins (theyre important in this chapter). I looked around us and there was a greenish lake, my fathers van, beer bottles/broken ones, and the tall trees that is surrounding us. Ashlen, Drake, and James!!! Ben and my father says. I thought why didnt my father call Ben? As I walked to father. Ill give you guys some beer if you kill Ben, father says. I was shocked if what he said. My cousins agreed but I didnt. I started to run to Ben, but it was too late. They started to drown him. No!! I yelled and started ...
One of the major reasons I love PoolForum is that it has always been open to new ideas.... Thats how Ben revolutionized the pool industry, right?! Back in the summer of 2014, Ben was talking about a phosphate project/experiment and toying around with the possibility of putting together a winterizing kit which included Orenda phosphate removers. I had hoped to participate in his experiment.... I dont really have any chemistry issues with my water, but I am interested in the idea of
One of the major reasons I love PoolForum is that it has always been open to new ideas.... Thats how Ben revolutionized the pool industry, right?! Back in the summer of 2014, Ben was talking about a phosphate project/experiment and toying around with the possibility of putting together a winterizing kit which included Orenda phosphate removers. I had hoped to participate in his experiment.... I dont really have any chemistry issues with my water, but I am interested in the idea of
He won an Oscar for Gandhi and hes got a knighthood to boot. But things might have turned out very differently, Ben Kingsley reveals all.
Visit Healthgrades for information on Dr. Ben Hwang, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Ben Kingsley says he might soon be shooting in the country; talks about his character in an upcoming sequel to a popular superhero film
Ben Stanton started in radio doing public affairs programs in Phoenix. He has worked as a reporter at commercial and public radio stations in Iowa and
BEN Affleck loves watching how audiences respond to his movie 'Argo', and has found it "rewarding" that they react to the story in exactly the way he had hoped.
If the market believes that forward guidance works, that might undermine it. Forward guidance will only work if the market doubts its effectiveness.
Jakob Goldenthal confirmed Eloni was none other than Elioneiai son of Caiaphas. The children of Elioneiai were his son Jonathias and his daughter Martha. Martha married Jeshua ben Gamaliel of the House of Phiabi. Therefore the son of Eloni from the Chain of Transmission being referred to as the Kahana, it would stand to reason was actually none other than Jeshua ben Gamaliel. At that moment in history my family obtained officially the title of Kahana.
Here are the explanations for the updated 2015 (effectively 2015-16) official USMLE Step 2 CK Sample Test Questions, which can be found here. Overall, there
Ben was awake and watching television when we walked into his room this morning. They had started him on his breathing trial at 8:00 AM. His vitals was good, no fever and alert at that time. His nurse Neelima who has been with him for 3 days in a row which is very odd said that she did some exercises with him this morning as it appears the physical therapists are not coming now. Marla and I did some exercises with him again a little later after I had rubbed lotion on his feet and hands. Ben was making silly faces during the morning. He could not make any verbal noises today like he did a couple of times yesterday. We were watching Rachael Ray and she had some burgers on her show. I asked Ben if he was hungry and he nodded yes, so that is a good sign. He has not had solid food for over 6 weeks. Bens long time buddy Ed Byrne came by to see him today. Problem was, when I spoke with Ed on the phone around 10:00 AM telling him Ben was awake enough for him to come, Ed didnt get there for over an ...
Ben Roethlisberger: Suspended For Six Games Ben Roethlisbergers suspension could be reduced to 4 games - TMZ Kevin and Danielle Jonas are a cute couple - JustJaredJr Chris Evans shows up at The Losers…
Last week, it was rumored that Jen was ready to divorce Ben as he moved out of their Brentwood home. "No matter what happens, Ben and Jen are committed to raising their family as one unit and will continue to do so as it has worked for them," a source told Us Weekly , "They are both committed to their family.". Let us know what you think by leaving us a line in our comments section below.. ...
17 July 1998 BSEbriefing from Ben GillNFU president Ben Gill went to Brussels yesterday (Thur) in a bid to correct many of the misunderstandings th
Con motivo del Día Internacional de los Tumores Cerebrales, la Asociación de Afectados de Tumores Cerebrales en España (ASATE) va a celebrar el sábado 8 de Junio el III Campeonato benéfico de pádel ASATE en el Parque Deportivo Puerta de Hierro. III Campeonato benéfico de pádel - Sábado 8 de junio 2013 Más Información..
Help Ben race his way over the obstacles and complete each level as fast as possible in order to advance to the next more challenging level in the Ben 10 Ultimate Moto 2 flash motorcycle game. A classic motorcycle racing, the use of the keyboard control
Even at the end of this video you referred to it as "Vinny Eastwoods article" when it was NOT an article, and NOT mine alone either, as it was written by Ben Vidgen, and this was explained in the opening seconds of the video ...
Everything you need to know about Ben Shive: Producer, Writer, Keyboardist, Arranger. Including Discography, News, Lyrics, Etc.
Hatem Ben Arfa has cancelled plans to meet with Newcastle United supporters on the same day the club holds an open training session at St James Park.
Learn faster with Brainscape on your web, iPhone, or Android device. Study Ben Dahlberg's flashcards for their ACC class now!
Get the NeoCounter [Airport Panel Edition] widget and many other great free widgets at Widgetbox! Not seeing a widget? (More info ...
Two shows about young, single adults gettin by and lookin for love may be compatible as schedule partners, but they are also very different sitcoms
Hey Ben, how can I really tighten my core? That is a question I hear every day! The truth? Well, its a lot of things that need to happen. You need a.... By: Ben Boudro. ...
Lajout de vitamine E par jour (400-1,200 UI) à lalimentation. Par conséquent, le taux plasmatique de vitamine E normales pourraient être maintenues et dans plusieurs patients amélioration de la fonction neurologique na été signalé. Lorsque supplémentation en vitamine E a été interrompu, le tocophérol plasmatique a chuté à des niveaux sous-optimaux ...
A lap szövege Creative Commons Nevezd meg! - Így add tovább! 3.0 licenc alatt van; egyes esetekben más módon is felhasználható. Részletekért lásd a felhasználási feltételeket ...
On Tuesday we got to see the famous Dr Ben Carson He is one of the best Doctors in the world. At 10 we had our morning tea then We hop onto the bus to go to the Telstraclear center in Mankau . Finally we got ...
Shop Soluble scavenger receptor cysteine-rich domain-containing protein ELISA Kit, Recombinant Protein and Soluble scavenger receptor cysteine-rich domain-containing protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Advanced Platelet Rich Fibrin (APRF) is a new advanced technology that helps heal wounds anywhere in the body, including those involved in oral surgery, using the patients own blood. Unlike Platelet Rich Plasma (PRP), it has no additives. In addition to that, APRF is very rich in platelets, leukocyte cells (growth factor cells) and contains…
In this study we adopted the guide-effector bispecific antibody design that we developed previously for cell-type-specific signaling modulation (8), and achieved cell-type-specific modulation of internalization. We show that when the guide-to-effector ratio crosses over a threshold (in our EphA2/ALCAM example, 1:5), a noninternalizing antigen (ALCAM) can be rendered internalizing by the bispecific. When the guide-to-effector ratio falls below the threshold, an internalizing antigen (EphA2) can be rendered non- or slowly internalizing by the bispecific. Thus in the context of bispecific targeting, the internalization behavior of a cell surface antigen is significantly impacted by its neighboring antigens, and can be readily manipulated in either direction through bispecific-based targeting of appropriately selected guide/effector pairs.. Our study has relevance to therapeutic development. In the direction of converting a noninternalizing into an internalizing antigen, our study has direct ...
Meg is talking with her dad when Ben comes driving down the road. Meg excuses herself and went into the house. Ben tries to introduce himself to Hank, but Hank comments that he knows Ben is the one that broke his daughters heart. Ben told Hank that he has come to Kansas so that he and Meg could put their problems behind them. Hank speculates that Meg came home because Ben still has a thing for his dead wife. Ben admits that might be why Meg came back, but that it was because of Meg that he has been able to get on with his life. Hank told Ben that sometimes Meg cares ends up caring for people more than they care about her. Ben assures Hank that he loves Meg. Hank told Ben that he would like to believe him, but hes been fooled before. Joan filled Hank in on everything Tim had done. Ben promises hes nothing like Tim, and that he would never jilt Meg. Hank threatens Ben that he will have to deal with him if he hurts Meg. Ben says he plans on convincing Meg they can be happy together and taking ...
Ben`s Bargains Bens Bargains is your one-stop destination for the best online deals. We are a team of dedicated deal hunters, focused on finding the hottest deals and lowest prices on the Internet.. For over 15 years, Bens Bargains has helped consumers like you save bundles of cash. We publish dozens of handpicked deals around the clock, so drop by early and often to get the lowdown on unbeatable bargains.. Copyright Bens Bargains v4.0 2017 ...
Rüben. Rüben, Zuckerrüben allgemein; Schwarze Bohnen- oder Rübenlaus (Aphis fabae Scop.) Cercospora-Blattfleckenkrankheit (Cercospora beticola).
Ok.. Cik Ben cakap ni segmen suai kenal kembali ... Cik Ben nak tau berapa ramai blogger yang baru lahir ni .. Cik Ben cakap lagi...inilah pekluang Yan nak tambah follower...hehehe... inila masanya yang ditunggu2.... Cik Ben cakap lagi yang Cik Ben akan follow Yan secara berhemah...fuhhh...betul ke ni Cik Ben???...dan segmen inii TERBUKA UNTUK SEMUA..dan mesti mengikut kriteria yang ditetapkan oleh Cik Ben seperti di bawah ni: ...
Dr. Ben van den Broek is a scientist and project leader at Wageningen Food & Biobased Research, The Netherlands. He is working in the field of biobased economy. His interest is replacing materials made from fossil oils with materials derived from plants or microorganisms.
Although hes got one of the citys greenest thumbs, Ben Flanner also apparently knows his way around the kitchen: next Monday, August 30, Brooklyn Granges...
On & On lyrics by Ben Lee: Without a gun, Id be defenseless against you. / Without a doubt Id lose everything i have. / Its clear youre
Written by Ben Goldfarb, Audiobook narrated by Will Damron. Sign-in to download and listen to this audiobook today! First time visiting Audible? Get this book free when you sign up for a 30-day Trial.
Ben Stiller is giving you his best Blue Steel.Heres the 28-year-old back in 1994 (left) -- and 15 years later, the 43-year-old version at an event in…
Docker CEO Ben Golub said his company is a key component of digital transformation as 'a way for you to get yourself to that point without having to lose the things that got you where you are right now.'
SARASOTA, Fla. -- This time a year ago Ben McDonald was well on his way to becoming something of a cult hero. The fact that he had pitched fewer than 120 innings in the big leagues and had more
Al fas masse timp che no met ca nissune ricete ni nuie altri. Al è che pardabon no ai fat nuie. Bon, si che o ai fat ma nol vignive fûr ben!!E, di colp, i pans a an tacât a vignî fûr ben e a an ancje miorât. E alore mi ai dite, "va, chest pan al podarès lâ fûr tal bloc". Di fat, mi va ben par me stesse, par no pierdi ricetis e cjatâlis plui facilmentri ...
The NBME has released the new 2016 USMLE Step 1 Sample Test Questions, which reflect a sizable decrease in the number of questions from 308 down to 280 and
Here is something I wanted to do for a long time: take on of my old "Shadow of Life" backgrounds, that I made almost 10 years ago, and upgrade it, to see what that game could look like if I was working on it now ...
DISCLAIMER: Any posts on LJ are posted by individuals acting in their own right and do not necessarily reflect the views of LJ. LJ will not be held liable for the actions of any user.. ...
A prosztata (d lmirigy) karcin m ja a f rfiak leggyakoribb tumoros betegs ge. Idej ben, azaz m g a t netek megmutatkoz sa el tt felfedezve j l gy gy
A trio of exclusive images from Malicks To the Wonder, his beautifully shot new film starring Ben Affleck, Rachel McAdams and Javier Bardem.
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011 ...
Gates of Hell and Ben Franklin - Ras Ben, Ras Ben 2016 and Beyond (=2025) Forecast, RAS BEN HEAVENS ARE OPEN, Quartz Crystal - Ras Ben, Ras Ben The Magi is Magnetic Part 1, Ras Ben Talks, National Geographic -Geography of Africa -NationalGeographic1705
Read Cell Adhesion Molecules Cellular Recognition Mechanisms by with Rakuten Kobo. The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto,...
Curious Dragons. Chapter 20. As the power of the amulet began to wash over the two battered teens, a wave of relief began to envelop them. It quickly brought their overly active bodies down from the adrenaline high. After that, a whirlwind of pink smoke began to pour out from the sides of the amulet. The whirlwind swiftly lifted the teens into the air and flew back towards the town. Kevin panicked a little since he was flying, but not in his original body, and Ben laughed at his lover and enjoyed the ride back to the hotel.. When the swirling cloud of smoke placed them, and surprisingly Kevins car, back at the hotel, Ben took his lovers hand and started walking back to the hotel. While walking, Kevin chucked his key to a valet and threatened to kill him if he scratched the car. The young man whimpered in fear and quickly went to retrieve the car. Ben slapped Kevins arm for his intimidation tactics, but made no attempts to correct him. Upon reentering their room, Ben sighed in relief and began ...
Ben is a happy go lucky dog who used to live in the staff housing of a power source company. When his previous owner retired, Ben was left behind often chased out by security guards and hostile residents. His rescuer wasnt able to take him so he was placed in an empty house lot by himself for two years and finally joined other foster dogs in a group home recently. Ben is looking for a moderately active family who can provide proper exercise so he can achieve ideal weight around fifty pounds and lessen stress on his joints. He loves to go out for walks and is laid back at home. Ben would be a great furry companion to someone who doesnt mind his age and appreciates his goofy nature with a sense of humour.. ...
Collects years 4-6 of Snakepit; the 3 panel daily autobiographical comic by Ben Snakepit. A partying, record store clerk, rock and roller, and big sweet softy, Ben tours the world with his band, J Church, drinks like a fish, goes to parties, and gets his heart broken over and over when hes not breaking hearts. The more you read, the more addictive it gets. Includes a compilation CD of Bens daily listening!. ...
Ben Turner (1912-1966) - Aspen Mountain Stream | The owner has authorized us to lower the price from $8,350 to $7,500. 35 x 43 framed.
After previously being rumored that Ben Affleck might get back together with Jennifer Lopez, it now seems that the Batman actor could actually reconcile with his estranged wife, Jennifer Garner. According to the latest rumors, the two have spent the night together, without their children. So, it surely seems that there may be room for a reconciliation between Ben Affleck and Jennifer Garner. Ben and Jennifer were seen together on Thursday night, in a Santa Monica restaurant. They went out without the children, so it definitely appears that Ben and Jennifer wanted to spend some time together, alone. However, this is not something shocking at all. In fact, Ben and Jennifer have constantly been seen together since their split.. So, the former couple has constantly been spotted together, enjoying dinners and vacations as a couple. Now, it seems that Ben and Jennifer are closer than ever. The two arrived together, in the same car. They also left the venue together. Their night out comes after the ...
Ben Andrews wants to support disabled people to knock down these barriers and teach them how they can have an active lifestyle with Empower You.
Buy Ben Sherman Men's Jeans and get the best deals ✅ at the lowest prices ✅ on eBay! Great Savings ✅ Free Delivery / Collection on many items
Ben will take the guesswork out of using the more advanced tools, techniques, and menus of Adobe® Photoshop®. Youll learn about which Adobe® Photoshop® tools are essential, and which you can ignore altogether.
Steelers QB Ben Roethlisberger should return Sunday vs. San Diego By Dale Grdnic | CBSSports.com December 4, 2012 3:07 pm ET http://www.cbssports.com/general/blog/nfl-rapidreports/21262392/steelers-qb-ben-roethlisberger-should-return-sunday-vs-san-diego
... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ... 2003). "Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166)". J ... "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule". Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, ...
... and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213-20. doi: ... domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of ... "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule ... a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137-43. PMID 2016320. Tsuge I, Utsumi KR, Ueda R, Takamoto S, ...
A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2. Mutations in the MMP2 gene ... allowing them to bind with cell receptors and influence cell signaling. Furthermore, many MMPs also activate other proMMPs ... Massagué J (July 2008). "TGFbeta in Cancer". Cell. 134 (2): 215-30. doi:10.1016/j.cell.2008.07.001. PMC 3512574 . PMID 18662538 ... "Human endometrial epithelial cells modulate the activation of gelatinase a by stromal cells". Gynecol. Obstet. Invest. 53 (2): ...
Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by ... These bioactive molecules play roles in coagulation, complement activation, DNA replication, cell-cycle control, cellular ... Placing a reactive group and a recognizable tag feature on the same molecule using a linker moiety gives an ABP molecule its ... Cell Proteomics 3(6):565-76 (2004). Bredemeyer A.J., Lewis R.M., Malone J.P., Davis A.E., Gross J., Townsend R.R., Ley T.J. A ...
... one of these adhesion proteins involved is ALCAM (Activated Leukocyte Cell Adhesion Molecule, also called CD166), and is under ... Apart from that, activated T-Cells can cross a healthy BBB when they express adhesion proteins. (Adhesion molecules could also ... because activated T-Cells can cross a healthy BBB when they express adhesion proteins. ... April 2000). "Adhesion molecules in multiple sclerosis: relation to subtypes of disease and methylprednisolone therapy". Arch. ...
Vascular cell adhesion molecule-1 (VCAM-1 - an integrin receptor) located on an endothelial cell, binds to the integrin VLA-4 ... but they do not adhere to their appropriate ligands until the leukocytes are activated by chemotactic agents or other stimuli ( ... T-cells gain access to the brain by allowing the cells to penetrate the blood brain barrier that normally restricts immune cell ... One approach to prevent an autoimmune reaction has been to block the action of VLA-4 so that self-reactive T-cells are unable ...
... or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells ... "E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro". Immunology. 77 (4 ... In endothelial cells, various cell-adhesion molecules including E-selectin, are shown to be upregulated upon exposure to ... Adhesion of colon cancer cells to endothelial cells expressing E-selectin induces a reverse signaling in the cancer cells that ...
... cell adhesion molecules, neuron-glia MeSH D12.776.395.550.200.250.150.050 -- activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.395.550.200.250.520.156 -- antigens, cd56 MeSH D12.776.395.550.200.250.520.578 -- ... vascular cell adhesion molecule-1 MeSH D12.776.395.550.550.500 -- lysosomal-associated membrane protein 1 MeSH D12.776.395.550. ... neural cell adhesion molecule l1 MeSH D12.776.395.550.200.275 -- integrin alphaxbeta2 MeSH D12.776.395.550.200.450 -- ...
... cell adhesion molecules, neuron-glia MeSH D23.050.301.350.250.150.050 --- activated-leukocyte cell adhesion molecule MeSH ... activated-leukocyte cell adhesion molecule MeSH D23.050.301.264.035.101 --- antigens, cd1 MeSH D23.050.301.264.035.102 --- ... activated-leukocyte cell adhesion molecule MeSH D23.101.100.110.101 --- antigens, cd1 MeSH D23.101.100.110.102 --- antigens, ... cell adhesion molecules MeSH D23.050.301.350.065 --- antigens, cd22 MeSH D23.050.301.350.098 --- antigens, cd24 MeSH D23.050. ...
... cell adhesion molecules, neuron-glia MeSH D12.776.543.550.200.250.150.050 -- activated-leukocyte cell adhesion molecule MeSH ... neural cell adhesion molecules MeSH D12.776.543.550.200.250.520.156 -- antigens, cd56 MeSH D12.776.543.550.200.250.520.578 -- ... vascular cell adhesion molecule-1 MeSH D12.776.543.550.425.150 -- calcium channels MeSH D12.776.543.550.425.150.400 -- calcium ... neural cell adhesion molecule l1 MeSH D12.776.543.550.200.275 -- integrin alphaxbeta2 MeSH D12.776.543.550.200.450 -- ...
... genes that encode endothelial cell adhesion molecules, causing decreased lymphocyte and leukocyte activation and hence ... T-cells are activated and more prone to apoptosis without KLF2, suggesting that KLF2 regulates T-cell quiescence and survival. ... This activates mechanosensitive channels, which in turn activates two pathways; the MEK5/ERK5 pathway, which activates MEF2, a ... but it is also expressed temporally during embryogenesis in erythroid cells, endothelium, lymphoid cells, the spleen, and white ...
APC affects endothelial cells by inhibiting inflammatory mediator release and down-regulating vascular adhesion molecules. This ... Activated leukocytes release these inflammatory mediators during inflammation, inhibiting the creation of both thrombomodulin ... "Product Information: Human Activated Protein C - Bovine Activated Protein C - Mouse Activated Protein C". Haematologic ... and it is these cells and leukocytes (white blood cells) that APC affects. Because of the crucial role that protein C plays as ...
... intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells ... ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells ... Frijns CJ, Kappelle LJ (Aug 2002). "Inflammatory cell adhesion molecules in ischemic cerebrovascular disease". Stroke: A ... With the roles of ICAM-1 in cell-cell adhesion, extravasation, and infection more fully understood, a potential role for ICAM-1 ...
... cells SGEF was recruited to the intracellular domain of the transmembrane adhesion molecule ICAM-1 upon leukocyte adhesion to ... that function to activate small G proteins. In their resting state G proteins are bound to guanosine diphosphate (GDP) and ... SGEF is also expressed in endothelial cells of the vasculature. Several widely used cell lines express this protein, these ... Cell. 15 (7): 3309-19. doi:10.1091/mbc.E04-02-0146. PMC 452585 . PMID 15133129. Samson et al 2013 "The Guanine-Nucleotide ...
2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes ... Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. ... Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c ( ... 1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the ...
β2 integrins on rolling leukocytes bind endothelial cellular adhesion molecules, arresting cell movement. ... Tight adhesion[edit]. At the same time, chemokines released by macrophages activate the rolling leukocytes and cause surface ... Leukocyte adhesion deficiency[edit]. Main article: Leukocyte adhesion deficiency. Leukocyte adhesion deficiency (LAD) is a ... white blood cells). The binding of PSGL-1 on the leukocyte to P-selectin on the endothelial cell allows for the leukocyte to ...
... cells as well as inducing the production of costimulatory molecules that allow the cell to bind to and activate T cells more ... leading to increased expression of adhesion molecules that recruit leukocytes to infected regions. This causes inflammation in ... of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells.[2] Furthermore, Anti ... SAg activation in T-cells leads to production of CD40 ligand which activates isotype switching in B cells to IgG and IgM and ...
... and changes in the avidity of cell adhesion molecules called integrins. Chemokines and their receptors play a crucial role in ... The subunit called Gβ activates an enzyme known as Phospholipase C (PLC) that is associated with the cell membrane. PLC cleaves ... This role of chemokine is strikingly similar to their normal function of localizing leukocytes to an inflammatory site. Human ... This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location ...
Selectins are adhesion molecules that facilitate the capture of circulating leukocytes. Sulfatide is also expressed on the ... Type 2 Natural killer T cells are able to recognize sulfatide/ CD1d tetramers, and as a result, they are activated by different ... macrophages dendritic cells Hepatocytes B cells tumor cells thymocytes Each of these different cell types are expressed in ... There are two types of cell subtypes that interact with CD1d cells: Type 1 Natural killer T cells and Type 2 Natural killer T ...
... cells as well as inducing the production of costimulatory molecules that allow the cell to bind to and activate T cells more ... leading to increased expression of adhesion molecules that recruit leukocytes to infected regions. This causes inflammation in ... and can activate up to 100% of T cells). The large number of activated T-cells generates a massive immune response which is not ... of the body's T-cells are activated, these SAgs are capable of activating up to 20% of the body's T-cells. Furthermore, Anti- ...
Naïve T cells express CCR7 receptor and adhesion molecules L-selectin and LFA-1. As naïve T cells move through the circulation ... In order for an adaptive immune response to occur T cells need to be activated. T cells become activated by recognising foreign ... consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for ... HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor ...
... and leukocytes: The inflamed blood vessels specifically express certain receptors, functioning as cell adhesion molecules, like ... Thrombosis and thrombolysis: Activated platelets are major components of blood clots (thrombi). Microbubbles can be conjugated ... Leukocytes possess high adhesion efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system. One ligand: ... and biomimcry of the leukocyte's selectin-integrin cell arrest system, having shown an increased adhesion efficiency, but yet ...
White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. ... C5a is an anaphylatoxin, causing increased expression of adhesion molecules on endothelium, contraction of smooth muscle, and ... C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the ... Both C5a and C5a des-Arg can trigger mast cell degranulation, releasing proinflammatory molecules histamine and TNF-α. C5a is ...
It has also been demonstrated that resistin upregulates intercellular adhesion molecule-1 (ICAM1) vascular cell-adhesion ... Inflammation is the first innate immune response to infection or irritation resulting from leukocyte (neutrophils, mast cells, ... nuclear factor kappa-light-chain-enhancer of activated B cells-mediated) fashion. ... In primates, pigs, and dogs, resistin is secreted by immune and epithelial cells, while, in rodents, it is secreted by adipose ...
... and their presentation to specific cell-surface receptors. The binding of versican with leukocyte adhesion molecules L-selectin ... "Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis". Nature. 457 (7225): 102-6. doi:10.1038 ... large family of cell adhesion molecules) with their cell surface receptors is sterically hindered. Expression of versican is ... Different tenascin domains interact with a wide range of cellular receptors, including integrins, cell adhesion molecules and ...
Leukocyte adhesion deficiency. *Familial cold urticaria. *Leukemia (chronic myelogenous (CML)) and other myeloproliferative ... B cells: releases antibodies and assists activation of T cells. *T cells: *CD4+ Th (T helper) cells: activate and regulate T ... T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors and CD4 molecules that, in ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ...
Activated Leukocyte Cell Adhesion Molecule), Authors: Esra Yavuz, Merve Oyken, Ayse Elif Erson Bensan. Published in: Atlas ... of plasma membrane focal adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ... of plasma membrane focal adhesion cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ... Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell ...
Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a marker of various cancers and mesenchymal stem cells, is ... Cell, Tumor, and Stem Cell Biology Attenuation of Melanoma Invasion by a Secreted Variant of Activated Leukocyte Cell Adhesion ... Aberrant expression profiles of activated leukocyte cell adhesion molecule (ALCAM/MEMD/CD166) were reported in a series of ... Remarkably, L1 neuronal cell adhesion molecule (L1CAM/CD171), another progression marker of several cancers including melanoma ...
OMIM: ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALCAM*Gene Ontology: Alcam *Mouse Phenome DB: Alcam *UCSC: Chr.16:52,248,996- ... activated leukocyte cell adhesion molecule. Synonyms: BEN, CD166, DM-GRASP, MuSC, SC1. Gene nomenclature, locus information, ... Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International ...
Activated-Leukocyte Cell Adhesion Molecule*Activated-Leukocyte Cell Adhesion Molecule. *Activated Leukocyte Cell Adhesion ... "Activated-Leukocyte Cell Adhesion Molecule" by people in this website by year, and whether "Activated-Leukocyte Cell Adhesion ... Cell Adhesion Molecules, Neuron-Glia [D23.050.301.350.250.150]. *Activated-Leukocyte Cell Adhesion Molecule [D23.050.301.350. ... Cell Adhesion Molecules, Neuron-Glia [D12.776.395.550.200.250.150]. *Activated-Leukocyte Cell Adhesion Molecule [D12.776. ...
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ABIN888844 from antibodies- ... anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) from antibodies-online. ... Itemanti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ... anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 550-583) antibody (Alexa Fluor 488) ...
Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ... Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by ...
Activated leukocyte cell adhesion molecule (ALCAM) is expressed on various cell types, including leukocytes, endothelial cells ... Activated leukocyte cell adhesion molecule (ALCAM) is expressed on various cell types, including leukocytes, endothelial cells ... Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis ZORA Maintenance. ... Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis. American Journal of ...
Activated Leukocyte Cell Adhesion Molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin. ... Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity ... You are here: Lirias › KU Leuven › Biomedical Sciences Group › Department of Imaging & Pathology › Translational Cell & Tissue ... of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions ...
Mesenchymal Stem Cell Surface Antigen SB-10 Corresponds to Activated Leukocyte Cell Adhesion Molecule and Is Involved in ... we report on the immunopurification of the SB-10 antigen and its identification as activated leukocyte-cell adhesion molecule ( ... thereby implicating a role for ALCAM during bone morphogenesis and adding ALCAM to the group of cell adhesion molecules ... The cell surface antigen recognized by monoclonal antibody SB-10 is expressed on human MSCs but is lost during their ...
An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in ... Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients. Last ...
Cavy Activated Leukocyte Cell Adhesion Molecule ELISA Kit-AAB59499.1 (MBS046317) product datasheet at MyBioSource, ELISA Kits ... Activated Leukocyte Cell Adhesion Molecule (ALCAM), ELISA Kit. Also Known As Cavy Activated Leukocyte Cell Adhesion Molecule ... Cell Adhesion Molecules (CAMs) Pathway Diagram. Cell Adhesion Molecules (CAMs) Pathway antibodies. Cell Adhesion Molecules ( ... This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), ...
Treatment Activated leukocyte cell adhesion molecule. Symptoms and causes Activated leukocyte cell adhesion molecule ... Description of disease Activated leukocyte cell adhesion molecule. ... Activated Leukocyte Cell Adhesion Molecule/CD166, a Marker of .... Activated Leukocyte Cell Adhesion Molecule/CD166, a Marker ... Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166/MEMD .... Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166/MEMD ...
Human Activated Leukocyte Cell Adhesion Molecule (ALCAM) CLIA Kit-AAI37097.1 (MBS2025416) product datasheet at MyBioSource, ... Activated Leukocyte Cell Adhesion Molecule (ALCAM), CLIA Kit. Also Known As Activated Leukocyte Cell Adhesion Molecule (ALCAM) ... Cell Adhesion Molecules (CAMs) Pathway Diagram. Cell Adhesion Molecules (CAMs) Pathway antibodies. Cell Adhesion Molecules ( ... This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), ...
Recombinant Activated Leukocyte Cell Adhesion Molecule (ALCAM), Cat#RPU40071. Write a Review Write a Review. × ... Recombinant Activated Leukocyte Cell Adhesion Molecule (ALCAM), Cat#RPU40071. Rating Required Select Rating. 1 star (worst). 2 ... Activated Leukocyte Cell Adhesion Molecule. Alternative Names. CD166; MEMD; Activated Leucocyte Cell Adhesion Molecule ... CD & Adhesion molecule; Tumor immunity;. Restriction. For Research Use Only. Not for use in diagnostic procedures, drug use, or ...
Monoclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM) - Human by USCNK ...
MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell ...
Activated Leukocyte Cell Adhesion Molecule) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA Kit » Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA ... Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA Kit. Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA ... Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA Kit. Rat ALCAM (Activated Leukocyte Cell Adhesion Molecule) ELISA ...
Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]. Wound Repair ... Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract] ... Our purpose was assess the impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM) on Human Vascular Endothelial Cells ( ... the following cell sublines were created; a control (HECVpEF) endothelial cell line and a ALCAM-knockdown (HECVALCAM/KD) cell ...
Activated leukocyte cell adhesion molecule (ALCAM) is a type I transmembrane protein member of the immunoglobulin superfamily ... Syntenin-1 and ezrin link Activated Leukocyte Cell Adhesion Molecule to the actin cytoskeleton. Publication. Publication. J. ... Syntenin-1 and ezrin link Activated Leukocyte Cell Adhesion Molecule to the actin cytoskeleton. J. Biol. Chem., 289(19), 13445- ... of cell adhesion molecules. Involved in important pathophysiological processes such as the immune response, cancer metastasis, ...
... on monocyte-lineage cells and in rheumatoid arthritis synovium. ... expression of activated leukocyte cell adhesion molecule (CD166 ... Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid ... OBJECTIVE: To determine whether monocyte/macrophage expression of the CD6 ligand, activated leukocyte cell adhesion molecule ( ... ALCAM was expressed on monocyte-lineage cells in situ in inflamed synovium from patients with RA (9 of 9), but not in ...
IMMUNOGLOBULIN SUPERFAMILY/CELL ADHESION MOLECULES (PROTEINS AND PEPTIDES); LEUKOCYTES + AMOEBOID BLOOD CELLS (BLOOD CELLS); ... Investigating the role of activated leukocyte cell adhesion molecule in vascular biology and its potential as a therapeutic ... TUMOUR GROWTH, GROWTH AND PROLIFERATION OF CANCER CELLS (PATHOLOGY); IMMUNE REACTION + IMMUNE RESPONSE (IMMUNOLOGY) ...
... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ... a novel activated leukocyte cell adhesion molecule (ALCAM) has been implicated in leukocyte transmigration across the ...
In this study, we investigated the role of activated leukocyte cell adhesion molecule (ALCAM/CD166), a member of the ... Here, we show that the viral transactivator Tax increases activated leukocyte cell adhesion molecule (ALCAM/CD166) expression. ... This molecule facilitates the migration of lymphocytes across the BBB endothelium. Targeting this molecule could be of interest ... We demonstrated that ALCAM is overexpressed on the surface of HTLV-1-infected lymphocytes, both in chronically infected cell ...
... regulates T cell responses in a murine model of food allergy, doi: 10.1111/cei.13104, category: Article ... Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy ... ALCAM ; CD166 ; activated leucocyte cell adhesion molecule ; food allergy. Abstract. Food allergy is a major public health ... Studies have shown that long-term interactions between activated leucocyte cell adhesion molecule (ALCAM/CD166) on the surface ...
Click here for Leukocyte adhesion molecule deficiency pictures! You can also find pictures of Itchy red bump disease, Lentigo ... hsa:214 ALCAM; activated leukocyte cell adhesion molecule hsa:914 CD2; CD2 molecule hsa:933 CD22;... Figure 2. Sequence ... Leukocyte Adhesion Process... From Horwitz Adhesion molecules involved in leukocyte emigration from vessels during inflammation ... Figure 1: Leukocyte migration from the circulation into target tissues is a multi-step process. The... Figure 1: Leukocyte ...
  • Spots in red represent proteins with a greater-than-1.5-fold decrease in the conditioned medium of cells treated with BB94. (asm.org)
  • RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. (mdpi.com)
  • The proteome represents the total complement of proteins present in a complex, an organelle, a cell, tissue, or an organism. (springer.com)
  • Identification of proteins from formalin-fixed paraffin-embedded cells by LC-MS/MS. Lab Invest J Tech Methods Pathol . (springer.com)
  • Because C5a-primed polymorphonuclear neutrophils (PMNs) induce hyperpermeability and phosphorylation of adherens junction proteins in endothelial cells ( 8 , 9 ) and in a similar manner C5aAP induces transient hypotension and neutropenia in rats ( 10 ), a hypothesis was put forth that C5aAP interactions with PMNs can initiate a series of events leading to the enhancement of VP. (aacrjournals.org)
  • Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. (genome.jp)
  • Membrane proteins that mediate immune cell-cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. (genome.jp)
  • A class of membrane proteins comprising the outer surfaces of cell membranes in the developing nervous system that is thought to be intimately involved in guiding development during embryonic life. (thefreedictionary.com)
  • Although inhibiting HSP90 by the antibiotic geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG), currently in phase III trial ( 5 - 7 ), it causes destabilization of its client proteins and induces cell apoptosis, proteomic analysis showed an elevated HSP70 expression compensating for the inhibition of HSP90 ( 8 ). (jcancer.org)
  • E-selectin recognizes and binds to sialylated carbohydrates present on the surface proteins of certain leukocytes. (wikipedia.org)
  • These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to facilitate transmigration of leukocytes across vascular endothelia in processes such as extravasation and the inflammatory response. (wikipedia.org)
  • Genetic variants variants in SGEF have been associated with coronary artery disease SGEF is part of a large class of proteins (GEFs) that function to activate small G proteins. (wikipedia.org)
  • GEFs activate G proteins by promoting nucleotide exchange. (wikipedia.org)
  • Crystal structures of the enterotoxins reveals that they are compact, ellipsoidal proteins sharing a characteristic two-domain folding pattern comprising an NH2-terminal β barrel globular domain known as the oligosaccharide / oligonucleotide fold, a long α-helix that diagonally spans the center of the molecule, and a COOH terminal globular domain. (wikipedia.org)
  • Selectins bind to sugar moieties and so are considered to be a type of lectin, cell adhesion proteins that bind sugar polymers. (wikipedia.org)
  • As the leukocyte rolls along the blood vessel wall, the distal lectin-like domain of the selectin binds to certain carbohydrate groups presented on proteins (such as PSGL-1) on the leukocyte, which slows the cell and allows it to leave the blood vessel and enter the site of infection. (wikipedia.org)
  • The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4-binding proteins. (wikipedia.org)
  • CD48 is a member of the CD2 subfamily of the immunoglobulin superfamily (IgSF) which includes SLAM (signaling lymphocyte activation molecules) proteins, such as CD84, CD150, CD229 and CD244. (wikipedia.org)
  • This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling, (e.g., the LYN-CD22-SHP-1 pathway). (wikipedia.org)
  • Sulfation of heparan sulfate GAGs helps give diversity to cell surface proteins and provides them with a unique sulfation pattern that allows them to specifically interact with other proteins. (wikipedia.org)
  • The C-terminal domain is where most of the variation is found between species and contains different amino acids which allow interaction with specific proteins in extracellular matrix or on cell surface. (wikipedia.org)
  • Class II MHC proteins are generally only found on the surface of specialised antigen-presenting cells (APCs). (wikipedia.org)
  • These interactions bring these proteins closer together, allowing the intracellular kinases present on the TCR, CD3 and CD4 proteins to activate each other via phosphorylation. (wikipedia.org)
  • T cells need another signal to become activated in addition to Signal 1, this is done by co-stimulatory molecules such as the proteins CD80 (B7.1) or CD86 (B7.2), although other additional co-stimulation molecules have been identified. (wikipedia.org)
  • This cleavage in turn activates PKA by exposing the catalytic sites of the C subunits, which can then phosphorylate an array of proteins in the cell. (wikipedia.org)
  • Subsequent work showed that release of LPS from gram negative microbes does not necessarily require the destruction of the bacterial cell wall, but rather, LPS is secreted as part of the normal physiological activity of membrane vesicle trafficking in the form of bacterial outer membrane vesicles (OMVs), which may also contain other virulence factors and proteins. (wikipedia.org)
  • Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (wikipedia.org)
  • HLA-identical siblings or HLA-identical unrelated donors often have genetically different proteins (called minor histocompatibility antigens) that can be presented by Major histocompatibility complex (MHC) molecules to the donor's T-cells, which see these antigens as foreign and so mount an immune response. (wikipedia.org)
  • Collectively, these enzymes are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. (wikipedia.org)
  • Superantigens, bacterial adhesions, and the actions of Yops (which are bacterial proteins once thought to be "Yersinia outer membrane proteins") that are encoded on the "[plasmid] for Yersinia virulence" - commonly known as the pYV - cause host pathogenesis and allow the bacteria to live parasitically. (wikipedia.org)
  • Many Ysc proteins also amalgamate to form a type-III secretory apparatus, which secretes many Yops into the host cell cytoplasm with the assistance of the "translocation apparatus", constructed of YopB and YopD. (wikipedia.org)
  • For example, YopN and TyeA are positioned as a plug on the apparatus so only their conformational change, induced by their interaction with certain host cell membrane proteins, will cause the unblocking of the secretory pathway. (wikipedia.org)
  • The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. (wikipedia.org)
  • The complex at the focal adhesions consists of several proteins such as vinculin, α-actin, paxillin, and talin, at the intracellular face of the plasma membrane. (wikipedia.org)
  • Greek: big eaters, from Greek μακρός (makrós) = large, φαγείν (phageín) = to eat) are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, cancer cells, and anything else that does not have the types of proteins specific to healthy body cells on its surface in a process called phagocytosis. (wikipedia.org)
  • Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. (wikipedia.org)
  • Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. (wikipedia.org)
  • It was discovered in 1984 when it was reported that infected RBCs had unusually large-sized cell membrane proteins, and these proteins had antibody-binding (antigenic) properties. (wikipedia.org)
  • In addition, in a cell culture model, irisin restored ox-LDL-induced human umbilical vein endothelial cell dysfunction by reducing the levels of inflammatory genes via inhibiting the reactive oxygen species (ROS)/ p38 MAPK/ NF-κB signaling pathway activation and inhibiting cell apoptosis via up-regulating Bcl-2 and down-regulating Bax and caspase-3 expression. (plos.org)
  • Thrombin is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca2+-independent pathway involved in release of P-selectin. (wikipedia.org)
  • He was the first to show that C3 nephritic factor is an autoantibody that activates the alternative complement pathway, a finding that suggested the potential of B cell or complement C5 depletion as adjunct therapies in certain forms of kidney inflammation. (wikipedia.org)
  • The activation of the JNK signal transduction pathway by MAP4K4 has been implicated in apoptotic regulation of many different cell types, tumorigenesis and/or inflammation. (wikipedia.org)
  • It was also shown that radiotherapy activates ADAM17 in non-small cell lung cancer, which results in shedding of multiple survival factors, growth factor pathway activation, and radiotherapy-induced treatment resistance. (wikipedia.org)
  • In the latter transcellular biosynthetic pathway, one cell type forms either the 5,6-dihydroxy-, 5-hydroxy, 14,15-dihydroxy- or a 15-hydroxy-eicosatetraenoate, and then passes this intermediate to a second cell type, which metabolizes it to the final LX product. (wikipedia.org)
  • C1q mediates the classical pathway by activating the C1 complex, which cleaves C4 and C2 into smaller fragments (C4a, C4b, C2a, and C2b). (wikipedia.org)
  • Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (wikipedia.org)
  • The concept of enzymatic regulation of leukocyte extravasation provides new insight into the multi-step adhesion cascade and opens new possibilities for inhibiting inappropriate inflammatory reaction through the use of small molecule enzyme inhibitors. (ahajournals.org)
  • As such, natalizumab may act to suppress inflammatory activity present at the disease site, and inhibit further recruitment of immune cells into inflamed tissues. (intekom.com)
  • In the setting of central nervous system (CNS) inflammation in MS, it is the interaction of alpha4beta1 with VCAM-1, CS-1 and osteopontin that mediates the firm adhesion and transmigration of leukocytes into the brain parenchyma and may perpetuate the inflammatory cascade in CNS tissue. (intekom.com)
  • Blockade of the molecular interactions of alpha4beta1 with its targets reduces inflammatory activity present in the brain in MS and inhibits further recruitment of immune cells into inflamed tissue, thus reducing the formation or enlargement of MS lesions. (intekom.com)
  • Components of the inflammatory response, including cytokine release and leukocyte adhesion, appear to play key roles in these deleterious effects. (medscape.com)
  • One of the pivotal mechanisms leading to neuroinflammation associated with human immunodeficiency virus type 1 (HIV-1) infection of the CNS involves breach of the BBB, resulting in influx of inflammatory cells in the CNS with ensuing neurological complications. (jneurosci.org)
  • It is accepted that inflammatory mediators released from leukocytes contribute to the generation of pain. (nih.gov)
  • Multiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration and tissue damage. (wikipedia.org)
  • Each of these cell types is found in acute and chronic inflammatory sites in association with expression of E-selectin, thus implicating E-selectin in the recruitment of these cells to such inflammatory sites. (wikipedia.org)
  • ICAM-1 ligation produces proinflammatory effects such as inflammatory leukocyte recruitment by signaling through cascades involving a number of kinases, including the kinase p56lyn. (wikipedia.org)
  • In general, leukocytes are involved in the defense of an organism and protect it from disease by promoting or inhibiting inflammatory responses. (wikipedia.org)
  • This role of chemokine is strikingly similar to their normal function of localizing leukocytes to an inflammatory site. (wikipedia.org)
  • C5a, the other cleavage product of C5, acts as a highly inflammatory peptide, encouraging complement activation, formation of the MAC, attraction of innate immune cells, and histamine release involved in allergic responses. (wikipedia.org)
  • This inflammatory reaction in endothelial cells promotes recruitment of leukocytes to lesions and may potentially promote atherogenesis. (wikipedia.org)
  • During an inflammatory response, stimuli such as histamine and thrombin cause endothelial cells to mobilize P-selectin from stores inside the cell to the cell surface. (wikipedia.org)
  • Since these characteristics are important in leukocyte extravasation, MCAM-1 may be an important part of the inflammatory response. (wikipedia.org)
  • Other chemokines are inflammatory and are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. (wikipedia.org)
  • Certain inflammatory chemokines activate cells to initiate an immune response or promote wound healing. (wikipedia.org)
  • Inflammatory: these are formed under pathological conditions (on pro-inflammatory stimuli, such as IL-1, TNF-alpha, LPS, or viruses) and actively participate in the inflammatory response attracting immune cells to the site of inflammation. (wikipedia.org)
  • One SGP-T derivative is a three amino acid sequence shown to be a potent anti-inflammatory molecule with systemic effects. (wikipedia.org)
  • These events regulate immune responses by controlling the access of leukocytes to sites of inflammatory or immune reaction in the body. (wikipedia.org)
  • The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair. (wikipedia.org)
  • A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. (wikipedia.org)
  • Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells present at the site of inflammation, such as mononuclear cells, and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process. (wikipedia.org)
  • Subsequent studies, however, found that these lipoxins, as well as their epimers, epi-LXA4 and LXB4, act primarily to dampen and resolve inflammation, i.e. they are anti-inflammatory cell signaling agents. (wikipedia.org)
  • However, it has been shown that genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle are differentially expressed in patients with fatal GvHD versus "indolent" GvHD. (wikipedia.org)
  • H1-antihistamines have been shown to attenuate NF-κB expression and mitigate certain inflammatory processes in associated cells. (wikipedia.org)
  • Like other anaphylatoxins, C3a is regulated by cleavage of its carboxy-terminal arginine, which results in a molecule with lowered inflammatory function (C3a desarginine). (wikipedia.org)
  • Bone marrow contains a rare population of mesenchymal stem cells (MSCs) capable of giving rise to multiple mesodermal tissues including bone, cartilage, tendon, muscle, and fat. (ovid.com)
  • While healthy people need ALCALM to activate their T cells to fight off foreign microbes in the body, in patients with an autoimmune disease, the activated T cells end up just fighting the patient's own tissues, rather than a foreign body. (eurekalert.org)
  • B cells are the predominant subset in most mucosa‐associated lymphoid tissues, whereas T cells are more frequent in peripheral LNs. (els.net)
  • Effector memory cells migrate preferentially to nonlymphoid tissues. (els.net)
  • Multipotent mesenchymal stromal cells (MSCs) are essential bone marrow components that have the potential to differentiate in vitro into tissues along mesenchymal lineages, including bone marrow stroma. (springer.com)
  • Analysis of precursor cells for osteogenic and hematopoietic tissues. (springer.com)
  • Devine SM, Cobbs C, Jennings M et al (2003) Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. (springer.com)
  • Opioid-containing immune cells extravasate using adhesion molecules and chemokines to accumulate in inflamed tissues. (nih.gov)
  • When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. (wikipedia.org)
  • White blood cells (leukocytes) perform most of their functions in tissues. (wikipedia.org)
  • Leukocytes use the blood as a transport medium to reach the tissues of the body. (wikipedia.org)
  • This modifies hepatic glucose homeostasis and may contribute to patterns of GLUT expression in chronic disease, as insulin resistance in humans have been linked to altered expression of GLUT isoforms by granulosa cells and adipose tissues. (wikipedia.org)
  • Xenotransplantation (xenos- from the Greek meaning "foreign"), is the transplantation of living cells, tissues or organs from one species to another. (wikipedia.org)
  • Such cells, tissues or organs are called xenografts or xenotransplants. (wikipedia.org)
  • Certain procedures, some of which are being investigated in early clinical trials, aim to use cells or tissues from other species to treat life-threatening and debilitating illnesses such as cancer, diabetes, liver failure and Parkinson's disease. (wikipedia.org)
  • If vitrification can be perfected, it could allow for long-term storage of xenogenic cells, tissues and organs so that they would be more readily available for transplant. (wikipedia.org)
  • The prevalence of basement membranes in the tissues of Eumetazoans means that most cell types require attachment to survive. (wikipedia.org)
  • After bone marrow transplantation, T cells present in the graft, either as contaminants or intentionally introduced into the host, attack the tissues of the transplant recipient after perceiving host tissues as antigenically foreign. (wikipedia.org)
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
  • Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan. (wikipedia.org)
  • Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. (wikipedia.org)
  • When mature they are divided into functionally distinct subsets that obey their own (mostly unknown) rules and that have countless direct and indirect effects on healthy tissues and immune cells, on pathogens and tissues enduring infections and the host responses to them. (wikipedia.org)
  • The lacZ reporter cleaves a substrate to produce a small molecule that can be detected in urine. (sciencemag.org)
  • Genetic, antibody and small molecule-based approaches allow them to define the role of trafficking molecules and mechanisms in models of autoimmune and infectious diseases. (wikipedia.org)
  • In 2006, in the course of acquiring an HDAC-focused program from Celera after its own initial discovery program had failed, Pharmacyclics also picked up Celera's small molecule BTK inhibitor discovery program for $2M in cash and $1M in stock and named the tool compound PCI-32765. (wikipedia.org)
  • However, it is less well known that immune cells also produce mediators that can effectively counteract pain. (nih.gov)
  • Second, there are leaks in the blood-brain barrier where immune cells infiltrate causing the known demyelination and axon destruction. (wikipedia.org)
  • CD40L plays a central role in costimulation and regulation of the immune response via T cell priming and activation of CD40-expressing immune cells. (wikipedia.org)
  • IFNγ is also produced by non-cytotoxic innate lymphoid cells (ILC), a family of immune cells first discovered in the early 2010s. (wikipedia.org)
  • The mechanism of the chemorepulsion of immune cells was first acknowledged by medical researchers at the Massachusetts General Hospital in Boston in early 2002. (wikipedia.org)
  • The chemorepulsion of immune cells was first postulated a priori based on the established migratory behavior of cells evidenced in several naturally occurring physiological processes: the development of the Central Nervous System, the establishment of immune-privileged sites, and thymic emigration. (wikipedia.org)
  • Other factors might also provide chemorepulsive effects on immune cells, and these inhibitory effects might be regulated by the tissue microenvironment. (wikipedia.org)
  • Although these locations are often physically isolated or segregated from access by immune cells, there are some functionally significant characteristics of such environments that are unique, and could potentially be replicated to keep immune cells away from targeted areas. (wikipedia.org)
  • Pathogens have evolved various strategies of evasion to thwart the host's mobilization of immune cells, some of which are relevant to immunrepulsion. (wikipedia.org)
  • This role is especially important because harmful cells that are missing MHC I markers cannot be detected and destroyed by other immune cells, such as T lymphocyte cells. (wikipedia.org)
  • Immune cells (white blood cells) in the donated tissue (the graft) recognize the recipient (the host) as foreign (nonself). (wikipedia.org)
  • The transplanted immune cells then attack the host's body cells. (wikipedia.org)
  • An immuno-competent graft is administered, with viable and functional immune cells. (wikipedia.org)
  • Nitric oxide is also an immune effector, mediating diverse activities of immune cells. (wikipedia.org)
  • They are found primarily on the surface of immune cells and are a subset of the I-type lectins. (wikipedia.org)
  • however, due to some pathogens being indigestible, they can be unable to resolve certain infections without the assistance of other types of immune cells. (wikipedia.org)
  • Form 2 is the most widely expressed form that is found in all circulating and immune cells. (wikipedia.org)
  • Innate lymphoid cells (ILCs) are a group of innate immune cells that are derived from common lymphoid progenitor (CLP) and belong to the lymphoid lineage. (wikipedia.org)
  • 2 Release of platelet activating factor (PAF) and endothelin-1 promotes vasoconstriction, 3 whereas production of von Willebrand factor (vWF), tissue factor (TF), plasminogen activator inhibitor (PAI)-1, and Factor V augment thrombosis. (ahajournals.org)
  • Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the platelet releases α- and dense granules and the inner walls of the granules are exposed on the outside of the cell. (wikipedia.org)
  • P-selectin is expressed on the surface of both stimulated endothelial cell and activated platelet and helps cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively. (wikipedia.org)
  • Sub-primate mammals, such as the mouse, rat, rabbit, cow, and pig, express platelet type 12-lipoxygenase but also a leukocyte type 12-lipoxygenase (also termed 12/15-lipoxygenase, 12/15-LOX or 12/15-LO) which is an ortholog of, and metabolically equivalent to, human 15-LO-1 in that it forms predominantly 15(S)-HpETE with 12(S)-HpETE as a minor product. (wikipedia.org)
  • This complex interacts with fibrinogen and thus plays an important role in platelet aggregation and adhesion to endothelial surfaces. (wikipedia.org)
  • During the development of the Central Nervous System, chemokinetic agents influence the localization of neuronal cells by either attracting or repelling the growing axon. (wikipedia.org)
  • Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC "DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. (wikipedia.org)
  • The difficulty to cure advanced colorectal cancers is at least partly attributed to the presence of a small population of highly-tumorigenic cancer cells termed cancer stem cells (CSCs) which are responsible for the initiation, progression and metastasis of colorectal cancer [ 2 , 3 , 4 , 5 , 6 ]. (mdpi.com)
  • Cancer cell invasion, ECM degradation, and metastasis are highly linked with the presence of invadopodia, protrusive and adhesive structures on cancer cells. (wikipedia.org)
  • The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling. (ptglab.com)
  • Moreover, growing evidence implies a role of adhesion GPCRs in tumour cell metastasis. (wikipedia.org)
  • This interaction can be tuned by the glycosylation pattern of PSGL-1, such that certain glycovariants of PSGL-1 will have unique affinities for different selectins, allowing in some cases for cells to migrate to specific sites within the body (e.g. the skin). (wikipedia.org)
  • The binding of versican with leukocyte adhesion molecules L-selectin, P-selectin, and CD44 is also mediated by the interaction of CS chains of versican with the carbohydrate-binding domain of these molecules. (wikipedia.org)
  • CD48 and CD2 molecular coupling together with other interaction pairs of CD28 and CD80, TCR and peptide-MHC and LFA-1 and ICAM-1 contribute to the formation of an immunological synapse between a T cell and an antigen presenting cell. (wikipedia.org)
  • Lipoxins (LXs or Lxs), an acronym for lipoxygenase interaction products, are bioactive autacoid metabolites of arachidonic acid made by various cell types. (wikipedia.org)
  • In the second mechanism, the Matthews-mechanism, Kester and Matthews suggested an interaction between a water molecule and the Zn2+ ion during the acid-base catalysis. (wikipedia.org)
  • The CD47/SIRPα interaction leads to bidirectional signaling, resulting in different cell-to-cell responses including inhibition of phagocytosis, stimulation of cell-cell fusion, and T-cell activation. (wikipedia.org)
  • abstract = "Human immunodeficiency virus (HIV)-associated increase in monocyte adhesion and trafficking is exacerbated by cocaine abuse. (elsevier.com)
  • Abstract Objective: Mast cell infiltration into airway smooth muscle (ASM) bundle is an important feature of asthma. (jove.com)
  • With several special designs, such as a peripheral water tank to balance negative pressure distribution in a marginal area of the chip, a screw valve to preserve the suction power during the step-by-step sample loading, and multistage branching "T" shape channels to separate cells evenly into the chambers, up to 2000 single cells can be well dispersed and analyzed at the same time using this chip. (rsc.org)
  • 23) evaluated circulating cell adhesion molecules before and after transluminal angioplasty of peripheral arteries. (thefreedictionary.com)
  • The course of the T2DM is characterized by insulin resistance and a progressive loss of β-cell mass, together with the onset of vascular complications including coronary heart disease, stroke, peripheral vascular disease, and end stage renal disease, making it a leading cause of death worldwide. (frontiersin.org)
  • Sulfatide is primarily found on the extracellular leaflet of the myelin plasma membrane produced by the oligodendrocytes in the central nervous system and in the Schwann cells in the peripheral nervous system. (wikipedia.org)
  • Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury, Liver Cirrhosis and Peripheral Vascular disease. (wikipedia.org)
  • Based on the structure-activity study of the COOH-terminal domain of C5a, peptide agonists with varied C5aR affinities and diverse selectivity to cells expressing C5aR were synthesized ( 5 ). (aacrjournals.org)
  • These cells contain and upregulate signal-sequence encoding mRNA of the beta-endorphin precursor proopiomelanocortin and the entire enzymatic machinery necessary for its processing into the functionally active peptide. (nih.gov)
  • This displaces the antigenic peptide away from the TCR and circumvents the normal mechanism for T-cell activation. (wikipedia.org)
  • NMR spectroscopy proved that the molecule is composed of four helices and connected by peptide loops with three disulphide bonds between helix IV and II, III. (wikipedia.org)
  • IL-17 acts with IL-22 (produced by T helper 17 cells) to induce expression of antimicrobial peptide by keratinocytes. (wikipedia.org)
  • Once at the lymph nodes, the APC begin to present antigen peptides that are bound to Class II MHC, allowing CD4+ T cells that express the specific TCRs against the peptide/MHC complex to activate. (wikipedia.org)
  • Cell-based aAPCs have been produced by transfecting murine fibroblasts to express specific peptide-loaded HLA molecules with co-stimulatory signal B7.1, and cell adhesion molecules ICAM-1 and LFA-3. (wikipedia.org)
  • However, γδ T cells are peculiar in that they do not seem to require antigen processing and major-histocompatibility-complex (MHC) presentation of peptide epitopes, although some recognize MHC class Ib molecules. (wikipedia.org)