Actinobacillus: A genus of PASTEURELLACEAE described as gram-negative, nonsporeforming, nonmotile, facultative anaerobes. Most members are found both as pathogens and commensal organisms in the respiratory, alimentary, and genital tracts of animals.Actinobacillus Infections: Infections with bacteria of the genus ACTINOBACILLUS.Actinobacillus pleuropneumoniae: A species of gram-negative, facultatively anaerobic coccobacillus-shaped bacteria that has been isolated from pneumonic lesions and blood. It produces pneumonia with accompanying fibrinous pleuritis in swine.Aggregatibacter actinomycetemcomitans: A species of Gram-negative, facultatively anaerobic spherical or rod-shaped bacteria indigenous to dental surfaces. It is associated with PERIODONTITIS; BACTERIAL ENDOCARDITIS; and ACTINOMYCOSIS.Actinobacillus suis: A species of gram-negative bacteria in the genus ACTINOBACILLUS. It is mainly a pathogen of PIGS, but also can infect HORSES.Pleuropneumonia: Inflammation of the lung parenchyma that is associated with PLEURISY, inflammation of the PLEURA.Actinobacillus equuli: A genus of gram-negative bacteria in the genus ACTINOBACILLUS, which is pathogenic for HORSES and PIGS.Swine Diseases: Diseases of domestic swine and of the wild boar of the genus Sus.Haemophilus: A genus of PASTEURELLACEAE that consists of several species occurring in animals and humans. Its organisms are described as gram-negative, facultatively anaerobic, coccobacillus or rod-shaped, and nonmotile.Aggressive Periodontitis: Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Aggregatibacter: A genus of PASTEURELLACEAE. Members are nonmotile, Gram-negative, facultatively anaerobic rods or coccobacilli. Its members are X factor (HEMIN) independent and variably dependent on V factor (NAD).Exotoxins: Toxins produced, especially by bacterial or fungal cells, and released into the culture medium or environment.Pasteurellaceae: A family of coccoid to rod-shaped nonsporeforming, gram-negative, nonmotile, facultatively anaerobic bacteria that includes the genera ACTINOBACILLUS; HAEMOPHILUS; MANNHEIMIA; and PASTEURELLA.Pasteurella: The oldest recognized genus of the family PASTEURELLACEAE. It consists of several species. Its organisms occur most frequently as coccobacillus or rod-shaped and are gram-negative, nonmotile, facultative anaerobes. Species of this genus are found in both animals and humans.Cytotoxins: Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Actinobacillosis: A disease characterized by suppurative and granulomatous lesions in the respiratory tract, upper alimentary tract, skin, kidneys, joints, and other tissues. Actinobacillus lignieresii infects cattle and sheep while A. equuli infects horses and pigs.Hemolysin Proteins: Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.Actinobacillus seminis: A species of gram-negative bacteria in the genus ACTINOBACILLUS, which causes EPIDIDYMITIS in SHEEP.Bacterial Toxins: Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.Periodontal Diseases: Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Gingiva: Oral tissue surrounding and attached to TEETH.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Bacterial Proteins: Proteins found in any species of bacterium.Transferrin-Binding Proteins: A class of carrier proteins that bind to TRANSFERRIN. Many strains of pathogenic bacteria utilize transferrin-binding proteins to acquire their supply of iron from serum.Dental Plaque: A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.Genes, Bacterial: The functional hereditary units of BACTERIA.Pleuropneumonia, Contagious: A pleuropneumonia of cattle and goats caused by species of MYCOPLASMA.Pasteurella multocida: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally found in the flora of the mouth and respiratory tract of animals and birds. It causes shipping fever (see PASTEURELLOSIS, PNEUMONIC); HEMORRHAGIC BACTEREMIA; and intestinal disease in animals. In humans, disease usually arises from a wound infection following a bite or scratch from domesticated animals.Eikenella corrodens: Gram-negative bacteria isolated from infections of the respiratory and intestinal tracts and from the buccal cavity, intestinal tract, and urogenital tract. They are probably part of the normal flora of man and animals.Mouth: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.Mannheimia: Genus of bacteria in the family PASTEURELLACEAE, comprising multiple species that do not ferment trehalose. Species include MANNHEIMIA HAEMOLYTICA; M. glucosida, M. granulomatis, M. ruminalis, and M. varigena.Porphyromonas gingivalis: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Capnocytophaga: A gram-negative gliding bacterium isolated from the oral cavity. It is a pathogen often causing PERIODONTITIS.Bacterial Outer Membrane Proteins: Proteins isolated from the outer membrane of Gram-negative bacteria.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)Palatine Tonsil: A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX. There is one on each side of the oropharynx in the fauces between the anterior and posterior pillars of the SOFT PALATE.Polysaccharides, Bacterial: Polysaccharides found in bacteria and in capsules thereof.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Prevotella intermedia: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium is a common commensal in the gingival crevice and is often isolated from cases of gingivitis and other purulent lesions related to the mouth.Pasteurellaceae Infections: Infections with bacteria of the family PASTEURELLACEAE.RNA, Ribosomal, 16S: Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.Anseriformes: An order of BIRDS comprising the waterfowl, particularly DUCKS; GEESE; swans; and screamers.Aspartate Ammonia-Lyase: An enzyme that catalyzes the conversion of aspartic acid to ammonia and fumaric acid in plants and some microorganisms. EC 4.3.1.1.Transferrin-Binding Protein B: A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.Bacterial Vaccines: Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.Eikenella: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the human mouth and intestine. Organisms of this genus can be opportunistic pathogens.KB Cells: This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.Bacterial Adhesion: Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Pasteurella Infections: Infections with bacteria of the genus PASTEURELLA.Tylosin: Macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.Bacteroides: A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.Periodontium: The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.

Actinobacillus succinogenes sp. nov., a novel succinic-acid-producing strain from the bovine rumen. (1/220)

Strain 130ZT was isolated from the bovine rumen. It is a facultatively anaerobic, pleomorphic, Gram-negative rod. It exhibits a 'Morse code' form of morphology, which is characteristic of the genus Actinobacillus. Strain 130ZT is a capnophilic, osmotolerant succinogen that utilizes a broad range of sugars. It accumulates high concentrations of succinic acid (> 70 g l-1). Strain 130ZT is positive for catalase, oxidase, alkaline phosphatase and beta-galactosidase, but does not produce indole or urease. Acid but no gas is produced from D-glucose and D-fructose. 16S rRNA sequence analysis places strain 130ZT within the family Pasteurellaceae; the most closely related members of the family Pasteurellaceae have 16S rRNA similarities of 95.5% or less with strain 130ZT. Strain 130ZT was compared with Actinobacillus lignieresii and the related Bisgaard Taxa 6 and 10. Based upon morphological and biochemical properties, strain 130ZT is most similar to members of the genus Actinobacillus within the family Pasteurellaceae. It is proposed that strain 130ZT be classified as a new species, Actinobacillus succinogenes. The type strain of Actinobacillus succinogenes sp. nov. is ATCC 55618T.  (+info)

Polynucleotide probes that target a hypervariable region of 16S rRNA genes to identify bacterial isolates corresponding to bands of community fingerprints. (2/220)

Temperature gradient gel electrophoresis (TGGE) is well suited for fingerprinting bacterial communities by separating PCR-amplified fragments of 16S rRNA genes (16S ribosomal DNA [rDNA]). A strategy was developed and was generally applicable for linking 16S rDNA from community fingerprints to pure culture isolates from the same habitat. For this, digoxigenin-labeled polynucleotide probes were generated by PCR, using bands excised from TGGE community fingerprints as a template, and applied in hybridizations with dot blotted 16S rDNA amplified from bacterial isolates. Within 16S rDNA, the hypervariable V6 region, corresponding to positions 984 to 1047 (Escherichia coli 16S rDNA sequence), which is a subset of the region used for TGGE (positions 968 to 1401), best met the criteria of high phylogenetic variability, required for sufficient probe specificity, and closely flanking conserved priming sites for amplification. Removal of flanking conserved bases was necessary to enable the differentiation of closely related species. This was achieved by 5' exonuclease digestion, terminated by phosphorothioate bonds which were synthesized into the primers. The remaining complementary strand was removed by single-strand-specific digestion. Standard hybridization with truncated probes allowed differentiation of bacteria which differed by only two bases within the probe target site and 1.2% within the complete 16S rDNA. However, a truncated probe, derived from an excised TGGE band of a rhizosphere community, hybridized with three phylogenetically related isolates with identical V6 sequences. Only one of the isolates comigrated with the excised band in TGGE, which was shown to be due to identical sequences, demonstrating the utility of a combined TGGE and V6 probe approach.  (+info)

Studies on time-kill kinetics of different classes of antibiotics against veterinary pathogenic bacteria including Pasteurella, Actinobacillus and Escherichia coli. (3/220)

A systematic analysis of the bacteriostatic/bactericidal effect of several antibiotics used in veterinary medicine was carried out by time-kill kinetic analysis using P. haemolytica, P. multocida, A. pleuropneumoniae, and E. coli. The antibiotics tested were enrofloxacin, danofloxacin, erythromycin, tilmicosin, penicillin G, ceftiofur and tetracycline. Unexpectedly, the antibiotics well characterized as bacteriostatic agents against human pathogens such as tetracycline and macrolides, showed bactericidal activity against P. haemolytica and A. pleuropneumoniae. In contrast, tetracycline and erythromycin were bacteriostatic and tilmicosin was bactericidal against P. multocida. In addition, P. multocida was killed by fluoroquinolones at a slower rate than the other bacteria. Spectrum analysis revealed that ceftiofur and tilmicosin were good substrates of the universal efflux pump, AcrA/B, but penicillin and tetracycline were not. The fluoroquinolones were modest substrates for AcrA/B.  (+info)

Utilization of electrically reduced neutral red by Actinobacillus succinogenes: physiological function of neutral red in membrane-driven fumarate reduction and energy conservation. (4/220)

Neutral red (NR) functioned as an electronophore or electron channel enabling either cells or membranes purified from Actinobacillus succinogenes to drive electron transfer and proton translocation by coupling fumarate reduction to succinate production. Electrically reduced NR, unlike methyl or benzyl viologen, bound to cell membranes, was not toxic, and chemically reduced NAD. The cell membrane of A. succinogenes contained high levels of benzyl viologen-linked hydrogenase (12.2 U), fumarate reductase (13.1 U), and diaphorase (109.7 U) activities. Fumarate reductase (24.5 U) displayed the highest activity with NR as the electron carrier, whereas hydrogenase (1.1 U) and diaphorase (0.8 U) did not. Proton translocation by whole cells was dependent on either electrically reduced NR or H2 as the electron donor and on the fumarate concentration. During the growth of Actinobacillus on glucose plus electrically reduced NR in an electrochemical bioreactor system versus on glucose alone, electrically reduced NR enhanced glucose consumption, growth, and succinate production by about 20% while it decreased acetate production by about 50%. The rate of fumarate reduction to succinate by purified membranes was twofold higher with electrically reduced NR than with hydrogen as the electron donor. The addition of 2-(n-heptyl)-4-hydroxyquinoline N-oxide to whole cells or purified membranes inhibited succinate production from H2 plus fumarate but not from electrically reduced NR plus fumarate. Thus, NR appears to replace the function of menaquinone in the fumarate reductase complex, and it enables A. succinogenes to utilize electricity as a significant source of metabolic reducing power.  (+info)

Microbial utilization of electrically reduced neutral red as the sole electron donor for growth and metabolite production. (5/220)

Electrically reduced neutral red (NR) served as the sole source of reducing power for growth and metabolism of pure and mixed cultures of H2-consuming bacteria in a novel electrochemical bioreactor system. NR was continuously reduced by the cathodic potential (-1.5 V) generated from an electric current (0.3 to 1.0 mA), and it was subsequently oxidized by Actinobacillus succinogenes or by mixed methanogenic cultures. The A. succinogenes mutant strain FZ-6 did not grow on fumarate alone unless electrically reduced NR or hydrogen was present as the electron donor for succinate production. The mutant strain, unlike the wild type, lacked pyruvate formate lyase and formate dehydrogenase. Electrically reduced NR also replaced hydrogen as the sole electron donor source for growth and production of methane from CO2. These results show that both pure and mixed cultures can function as electrochemical devices when electrically generated reducing power can be used to drive metabolism. The potential utility of utilizing electrical reducing power in enhancing industrial fermentations or biotransformation processes is discussed.  (+info)

Electricity generation in microbial fuel cells using neutral red as an electronophore. (6/220)

Neutral red (NR) was utilized as an electron mediator in microbial fuel cells consuming glucose to study both its efficiency during electricity generation and its role in altering anaerobic growth and metabolism of Escherichia coli and Actinobacillus succinogenes. A study of chemical fuel cells in which NADH, NR, and ferricyanide were the electron donor, the electronophore, and the electron acceptor, respectively, showed that electrical current produced from NADH was proportional to the concentration of NADH. Fourfold more current was produced from NADH in chemical fuel cells when NR was the electron mediator than when thionin was the electron mediator. In microbial fuel cells in which E. coli resting cells were used the amount of current produced from glucose when NR was the electron mediator (3.5 mA) was 10-fold more than the amount produced when thionin was the electron mediator (0.4 mA). The amount of electrical energy generated (expressed in joules per mole of substrate) and the amount of current produced from glucose (expressed in milliamperes) in NR-mediated microbial fuel cells containing either E. coli or A. succinogenes were about 10- and 2-fold greater, respectively, when resting cells were used than when growing cells were used. Cell growth was inhibited substantially when these microbial fuel cells were making current, and more oxidized end products were formed under these conditions. When sewage sludge (i.e., a mixed culture of anaerobic bacteria) was used in the fuel cell, stable (for 120 h) and equivalent levels of current were obtained with glucose, as observed in the pure-culture experiments. These results suggest that NR is better than other electron mediators used in microbial fuel cells and that sludge production can be decreased while electricity is produced in fuel cells. Our results are discussed in relation to factors that may improve the relatively low electrical efficiencies (1.2 kJ/mol) obtained with microbial fuel cells.  (+info)

Comparative pathogenicity of different Actinobacillus suis O/K serotypes. (7/220)

The pathogenicity of Actinobacillus suis serotypes O1/K1 (strain SO4), O1/K2 (strain C84), and O2/K2 (strain H91-0380) was evaluated in specific-pathogen-free (SPF) piglets challenged by intraperitoneal inoculation with approximately 1 x 10(7) colony-forming units per mL. All 3 strains produced peritonitis, but differences were observed in the composite histopathologic scores (P = 0.001) and in their ability to spread (P = 0.008) at 7 h post challenge. The O2/K2 strain caused the most severe peritonitis and disseminated most widely to other tissues. Moderate lesions were seen with the O1/K2 strain while the O1/K1 strain caused mild lesions and remained largely localized to the peritoneum. In an attempt to explain the basis of observed differences, the serum sensitivity of 9 A. suis strains with different O and K types was assessed. Regardless of the O/K type, all of the isolates tested were serum resistant. Moreover, most A. suis isolates grew as well or better in complement-replete sera as they did in complement-depleted sera. These observations indicate that although 02 and K2 strains had a greater propensity to cause a disseminating septic inflammatory response in pigs, they were no more resistant to complement-mediated killing than O1 strains.  (+info)

A gene cluster for the synthesis of serotype d-specific polysaccharide antigen in Actinobacillus actinomycetemcomitans. (8/220)

The serotype d antigen of Actinobacillus actinomycetemcomitans consists of D-glucose, D-mannose, and L-rhamnose in a molar ratio of 1:2:1. A gene cluster involved in the synthesis of serotype-specific polysaccharide antigen was cloned from the chromosomal DNA of A. actinomycetemcomitans IDH 781 (serotype d). This cluster consisted of 12 open reading frames. Insertional inactivation of six genes in this cluster resulted in loss of ability of A. actinomycetemcomitans IDH 781 cells to produce the polysaccharide. Comparing the structure of the gene cluster with similar clusters from other serotypes of A. actinomycetemcomitans, showed that eight genes are unique to serotype d; the other four genes are involved in the biosynthesis of dTDP-L-rhamnose. These results suggest that the synthesis and structure of serotype d-specific polysaccharide of A. actinomycetemcomitans is quite different from those of other serotype strains.  (+info)

Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical isolate PO 1021-7
TY - GEN. T1 - Experimental and modelling studies of the bioconversion of glycerol to succinic acid by actinobacillus succinogenes. AU - Vlysidis, Anestis. AU - Du, Chenyu. AU - Webb, Colin. AU - Theodoropoulos, Constantinos. PY - 2008/12/1. Y1 - 2008/12/1. N2 - An unstructured kinetic model for the growth of Actinobacillus succinogenes on glycerol as the only carbon source is proposed in this study. The model describes cell growth considering both substrate and product inhibition. and its parameters are estimated by fitting the model predictions to experimental data. Substrate consumption and product formation rates are described by the Luedeking-Piret model. The main product of the process is succinic acid while by-products like acetate, formate and ethanol have very low concentrations. The main environmental factors that affect the bioprocess were examined and optimum conditions in terms of yield, final succinic acid concentration and productivity were evaluated by a factorial experimental ...
Succinic acid (SA) is poised to become a significant building-block or platform chemical in the bio-based economy. Of the microbial strains that show promise for biological SA production, the wild-type bacterium Actinobacillus succinogenes is one of the top-contenders. While strides have been made towards understanding the behaviour of the organism and developing the fundamentals for an industrial process based on the organism, there is still a large scope of research required and a multitude of challenges to be addressed. In particular, an improved understanding of the metabolism of the organism under favourable biofilm conditions is required and its potential as a microbial host in a biorefinery setting needs to be established. Therefore, the aim of this thesis is to develop a fundamental understanding of the central metabolism of the organism under biofilm conditions on relevant substrates, and to determine its performance as a SA producer on scalable biorefinery streams. Continuous operation ...
Looking for Actinobacillus capsulatus? Find out information about Actinobacillus capsulatus. A genus of gram-negative, immotile and nonspore-forming, oval to rod-shaped, often pleomorphic bacteria which occur as parasites or pathogens in mammals ,... Explanation of Actinobacillus capsulatus
Biohazard level, growth media and temperature, gram stain, industrial applications and more information for Actinobacillus hominis.
Actinobacillus equulis: especie que se encuentra en la cavidad bucal y amígdalas del caballo y causa lesiones supurativas de los riñones y articulaciones de los cerdos y caballos y endocarditis en el cerdo ...
University of California School of Veterinary Medicine, Department of Medicine and Epidemiology, Davis, CA 95616 Introduction and Objectives. Bacterial infections are the leading cause of death in foals during the first month of life. Ceftiofur, a 3rd-generation cephalosporin, shows excellent in vitro activity against many Gram-positive and Gram-negative bacteria, including E. coli, Actinobacillus spp, and other important pathogens of neonatal foals. This antimicrobial has recently been approved for treating Streptococcal respiratory tract infections in horses at a 24-hour dosage interval and at doses (2.2 to 4.4 mg/kg IM) substantially lower than those recommended for use of other 3rd-generation cephalosporins. The pharmacokinetics of ceftiofur administered IM to foals and adult horses have been reported, but no data is available concerning the pharmacokinetics of ceftiofur after IV use, the preferred administration route for critically ill foals.. The objectives of this study were:. 1. To ...
Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis. Among its virulence factors, a leukotoxin is suggested to play an important role in the pathogenicity. Periodontal infections with strains producing high levels of the leukotoxin are strongly associated with severe disease. Leukotoxin selectively kills human leukocytes and can disrupt the local defense mechanisms. Previous studies examining the role of the leukotoxin in host-parasite interactions have mainly focused on polymorphonuclear leukocytes (PMNs). In the inflamed periodontium, macrophages play a significant role in the regulation of the inflammatory reactions and the tissue breakdown and remodeling.. Thus, the aim of this dissertation was to investigate death mechanisms of human macrophages exposed to leukotoxin.. Human lymphocytes, PMNs, and monocytes/macrophages isolated from venous blood were exposed to purified leukotoxin or live A. actinomycetemcomitans ...
TY - JOUR. T1 - Infection by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, and antibody responses at different ages in humans.. AU - Nakagawa, S.. AU - Machida, Y.. AU - Nakagawa, Taneaki. AU - Fujii, H.. AU - Yamada, S.. AU - Takazoe, I.. AU - Okuda, K.. PY - 1994/1. Y1 - 1994/1. N2 - This study examined the serum IgG and IgM responses against Porphyromonas gingivalis and 3 serotypes of Actinobacillus actinomycetemcomitans, and the correlations of these responses with age and homologous infection. A total of 90 individuals were included in this study: 40 subjects with gingivitis, 40 periodontally healthy subjects, and 10 adult periodontitis subjects. The subjects in the gingivitis and periodontally healthy groups were divided into 4 stages based on their physiological age: early childhood, school age, puberty, and adult. In the gingivitis group, there was a positive correlation between increase in age and increase in serum IgG antibody levels against P. gingivalis until ...
Two previous studies have observed natural transformation in A. actinomycetemcomitans. Tøonjum et al. (30) used a broth-based method and identified two naturally competent strains among five study strains of A. actinomycetemcomitans with transformation frequencies of 1.3 × 10−3 and 6.2 × 10−5. In our present study, we identified a single highly competent A. actinomycetemcomitans strain among 17 strains examined. Although this is an apparently lower prevalence of naturally competent A. actinomycetemcomitans strains than was reported by Tøonjum et al., the transformation frequencies reported in this study were similar.. Sato et al. (23) generated transposon insertional mutants from the A. actinomycetemcomitans strain Y4 by natural transformation. The transformation was performed with broth-cultured exponential-phase A. actinomycetemcomitans cells. However, strain Y4 was not transformable in our study. While the loss of competence is sometimes a consequence of laboratory propagation, it is ...
0165] (1) Wilson M, Henderson, B. Virulence factors of A. actinomycetemcomitans revenant to the pathogenesis of inflammatory periodontal diseases. FEMS 1995:17:365-379. [0166] (2) Nowotny A, Behling U H, Hammond B, et al. Release of toxic microvesicles by Actinobacillus actinomycetemcomitans. Infect Immun 1982:37:151-154. [0167] (3) Kaplan J B, Perry M B, MacLean L L, Furgang D, Wilson M E, Fine D H. Structural and genetic analyses of 0 polysaccharide from Actinobacillus actinomycetemcomitans serotype f. Infect Immun 2001:69:5375-5384. [0168] (4) Rosan B, Slots J, Lamont R J, Listgarten M A, Nelson G M. Actinobacillus actinomycetemcomitans fimbriae. Oral Microbiol Immunol 1988:3:58-63. [0169] (5) Inouye T, Ohta H, Kokeguchi S, Fukui K, Kato K. Colonial variation and fimbriation of Actinobacillus actinomycetemcomitans. FEMS microbiology letters 1990: 57: 13-17. [0170] (6) Kaplan J B, Schreiner H C, Furgang D, Fine D H. Population structure and genetic diversity of Actinobacillus ...
Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillus actinomycetemcomitans serotypes a, c, d and e
A little over two years ago, we commented on a general rise in the frequency of Actinobacillus suis (A. suis) isolation from our swine tissue submission cases, and wondered if it was related to the increased porcine circovirus type 2 (PCV2) activity (National Hog Farmer North American Preview, June 6, 2008).
Actinobacillus suis has been isolated from the lungs of a 9-month-old cat. The bacterium was characterized biochemically as well as genetically, and its sensitivity profile to different antimicrobial agents was established. The role of this isolate in the cats condition is discussed ...
Many gram-positive and gram-negative bacterial species express LuxS and secrete and respond in various ways to a signal that is related to autoinducer 2 of V. harveyi (4, 7, 9, 10, 14, 16, 18, 19, 20, 21, 30, 31, 41). However, few of these organisms possess the dedicated two-component circuit that mediates the cell density-dependent response of V. harveyi to AI-2. Our previous studies showed that AI-2 secreted by the oral pathogen A. actinomycetemcomitans was capable of inducing V. harveyi bioluminescence (10) and also influenced aerobic growth of A. actinomycetemcomitans under iron-limiting conditions (9) These studies also suggested that AI-2-mediated regulation of iron uptake and storage genes contributed to optimal growth of A. actinomycetemcomitans under iron limitation. However, the mechanism by which A. actinomycetemcomitans responds to AI-2 is not fully understood. Analysis of the complete genome sequence of A. actinomycetemcomitans HK1651 (26; www.oralgen.lanl.gov ) indicates that this ...
A disease characterized by suppurative and granulomatous lesions in the respiratory tract, upper alimentary tract, skin, kidneys, joints, and other tissues. Actinobacillus lignieresii infects cattle and sheep while A. equuli infects horses and pigs ...
Wooden Tongue in Cattle Also known as: Actinobacillosis Wooden tongue (also known as Actinobacillosis) is a well-defined disease of the soft tissues of the mouth region in adult cattle. It is caused by Actinobacillus lignieresii, part of the normal bacterial flora of the upper digestive tract.
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Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR ...
Abiotrophia balaenopterae Lawson et al. 1999, sp. nov. (Part 2) Abiotrophia elegans Roggenkamp et al. 1999, sp. nov. (Part 1) Acidovorax defluvii Schulze et al. 1999, sp. nov. (Part 4) Actinobacillus succinogenes Guettler et al. 1999, sp. nov. (Part 1) Actinobispora alaniniphila Xu et al. 1999, sp. nov. (Part 2) Actinobispora aurantiaca Xu et al. 1999, sp. nov. (Part 2) Actinobispora xinjiangensis Xu et al. 1999, sp. nov. (Part 2) Actinomyces bowdenii Pascual et al. 1999, sp. nov. (Part 4) Aerococcus christensenii Collins et al. 1999, sp. nov. (Part 3) Agrobacterium meteori Rüger and Höfle 1992 is assigned to be a synonym of Agrobacterium atlanticum Rüger and Höfle 1992. (Part 1) Agrococcus citreus Wieser et al. 1999, sp. nov. (Part 3) Ahrensia Uchino et al. 1999, gen. nov. (Part 1) Ahrensia kielensis corrig. (ex Ahrens 1968) Uchino et al. 1999, sp. nov., nom. rev. - Synonym: Agrobacterium kieliense Ahrens 1968. (Part 1) Alterococcus Shieh and Jean 1999, gen. nov. (Part 2) Alterococcus ...
Effective publication: POHL (S.): Reklassifizierung der gattung Actinobacillus Brumpt 1910, Haemophilus Winslow et al. 1971 und Pasteurella Trevisan 1887 anhand phänotypischer und molekularer daten, insbesondere der DNS-verwandtschaften bei DNS: DNS-hybridisierung in vitro und vorschlag einer neuen familie, Pasteurellaceae. Inaug. Diss. Phillips-Universität Marburg/Lahn. Mauersberger, Marburg, 1979 ...
Actinobacillus pleuropneumoniae serotype 3 UPF0263 protein APJL_1366 (APJL_1366) datasheet and description hight quality product and Backed by our Guarantee
Actinobacillus pleuropneumoniae ApaA protein: an antigenic membrane protein from Actinobacillus pleuropnemoniae homology to ABC transporters; amino acid sequence in first source
Fifty randomly selected fattening pig herds were studied to investigate the epidemiological characteristics of infections with Actinobacillus pleuropneumoniae serovars 2, 3 and 9, and to identify risk factors for their within-herd seroprevalences. Information about 13 farm characteristics was obtained by means of a questionnaire and used to assess potential risk factors for the percentage of slaughter pigs with antibodies against each of the three serovars. The presence of antibodies was measured with an indirect ELISA. The median within-herd seroprevalence for serovar 2 was 58 per cent (range 0 to 100 per cent), for serovar 3, 53 per cent (range 10 to 95 per cent), and for serovar 9, 35 per cent (range 5 to 100 per cent). All but one farm tested positive for A pleuropneumoniae serovar 2, and all the farms were positive for A pleuropneumoniae serovars 3 and 9. There was a positive association (P<0.05) between each pair of serovars. The within-herd seroprevalence of serovar 2 was ...
0004] It is commonly known how to produce the RTX-toxin ApxI by culturing Actinobacillus pleuropneumoniae in a culturing medium to which a calcium salt (i.e. a chemical compound, based on an acid, formed by replacing all or part of the hydrogen ions of the acid with one or more calcium ions) is added. In particular, EP 0 453 024 already describes such a method (see "Example 2", paragraph 2 "Purification and characterisation of hemolysin", subparagraph "Methods"). Note that ApxI used to be referred to as "HLY" (see Frey et al. in "J Gen Microbiol. 1993 August; 139(8): 1723-8"). From this EP patent it is known to add a calcium compound (CaCl2) to the medium. Indeed, in Microbiol Pathogenesis 37 (2004) 29-33 it is stated that transcriptional activity of the ApxI operon is enhanced by addition of calcium to the growth medium. This way, high levels of ApxI can be provided for. The medium should support the growth of APP bacteria. It is commonly known how to constitute a medium that supports growth of ...
MUNOZ, D; QUEZADA, M y RUIZ, A. Serological behaviour study of Actinobacillus pleuropneumoniae (App) in commercial swine herds from the central region of Chile. Arch. med. vet. [online]. 2008, vol.40, n.2, pp.147-153. ISSN 0301-732X. http://dx.doi.org/10.4067/S0301-732X2008000200006.. In Chile, there was only one existing study on App. This study was designed to determine the maternal immunity duration, the age of seroconversion and the apparent and true prevalence in animals from 7 swine commercial herds. 60 samples were taken per herd and divided into 10 serum samples from animals of 4, 6,10,14,18and21 weeks of age, which were analyzed by ELISA®. Out of the 420 samples, 134 were positive with 112 of them belonging to pigs under 10 weeks of age while only 22 were from animals over 10 weeks of age, which seroconverted presumably due to a natural infection. Regarding maternal immunity duration it was found that around the 10th week of age the animals lose their colostrum antibodies. In ...
Actinobacillus pleuropneumoniae ATCC ® 33590™ Designation: Femo TypeStrain=True Application: Characterization Respiratory research
Biomarkers of infection were screened for their possible role as evaluators of antibiotic treatment in an aerosol infection model of porcine pneumonia caused by Actinobacillus pleuropneumoniae (Ap). Following infection of 12 pigs, clinical signs of pneumonia developed within 20 h, whereafter the animals received a single dose of either danofloxacin (2.5 mg/kg) or tiamulin (10 mg/kg). To test the discriminative properties of the biomarkers, the dosage regimens were designed with an expected difference in therapeutic efficacy in favour of danofloxacin. Accordingly, the danofloxacin-treated pigs recovered clinically within 24h after treatment, whereas tiamulin-treated animals remained clinically ill until the end of the study, 48 h after treatment. A similar Picture was seen for the biomarkers of infection. During the infection period, plasma C-reactive protein (CRP), interleukin-6 and haptoglobin increased, whereas plasma zinc, ascorbic acid and alpha-tocopherol decreased. In the ...
Periodontitis is mankinds most common chronic inflammatory disease. One severe form of periodontitis is localized aggressive periodontitis (LAP), a condition to which individuals of African origin demonstrate an increased susceptibility. The main causative organism of this disease is Actinobacillus …
Aggregatibacter aphrophilus (formerly Haemophilus aphrophilus and H. paraphrophilus ) is part of the normal oropharyngeal flora. It is a
SUMMARY. A case of bilateral epididymitis in a young Friesland bull is described. Actino-bacillis seminis was isolated from the bulls semen. The organism proved to be identical in microscopical, cultural and biochemical characteristics to strains isolated from rams. Serum from this animal, when subjected to a complement fixation test, yielded a suspicious reaction against an antigen prepared from the isolate of a naturally infected ram with clinical epididymitis. Blood sera from two bulls in the Orange Free State gave positive and suspicious reactions respectively to the same antigen.. ...
ID ACTP7_1_PE100 STANDARD; PRT; 215 AA. AC ACTP7_1_PE100; B3GZU0; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE SubName: Full=Cytochrome c-type protein NrfB; (ACTP7_1.PE100). GN Name=nrfB; OrderedLocusNames=APP7_0100; OS ACTINOBACILLUS PLEUROPNEUMONIAE SEROVAR 7 STR. AP76. OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Actinobacillus. OX NCBI_TaxID=537457; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ACTP7_1.PE100. CC Actinobacillus pleuropneumoniae serovar 7 str. AP76, complete genome. CC sequence. CC -!- ANNOTATIONS ORIGIN:B3GZU0_ACTP7 CC -!- GENE_FAMILY: HOG000278525 [ FAMILY / ALN / TREE ] DR UniProtKB/Swiss-Prot; B3GZU0; -. DR EMBL; CP001091; ACE60752.1; -; Genomic_DNA. DR RefSeq; YP_001967894.1; NC_010939.1. DR ProteinModelPortal; B3GZU0; -. DR STRING; B3GZU0; -. DR GeneID; 6397435; -. DR GenomeReviews; CP001091_GR; APP7_0100. DR ...
Food animals in the United States are often exposed to antimicrobials to treat and prevent infectious disease or to promote growth. Many of these antimicrobials are identical to or closely resemble drugs used in humans. Precise figures for the quantity of antimicrobials used in animals are not publicly available in the United States, and estimates vary widely. Antimicrobial resistance has emerged in zoonotic enteropathogens (e.g., Salmonella spp., Campylobacter spp.), commensal bacteria (e.g., Escherichia coli, enterococci), and bacterial pathogens of animals (e.g., Pasteurella, Actinobacillus spp.), but the prevalence of resistance varies. Antimicrobial resistance emerges from the use of antimicrobials in animals and the subsequent transfer of resistance genes and bacteria among animals and animal products and the environment. To slow the development of resistance, some countries have restricted antimicrobial use in feed, and some groups advocate similar measures in the United States. ...
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3.0.CO;2-5. PMID 10710235. Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317-20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151. Angel TA, Faust CJ, Gonzales JC, et al. (1993). "Genetic mapping of the X-linked dominant mutations striated (Str) and bare patches (Bpa) to a 600-kb region of the mouse X chromosome: implications for mapping human disorders in Xq28". Mamm. Genome. 4 (3): 171-6. doi:10.1007/BF00352233. PMID 8439729. Levin ML, Chatterjee A, Pragliola A, et al. (1996). "A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28". Genome Res. 6 (6): 465-77. doi:10.1101/gr.6.6.465. PMID 8828036. Heiss NS, Rogner UC, Kioschis P, et al. (1996). "Transcription mapping in a 700-kb region around the DXS52 locus in Xq28: isolation of six novel transcripts and a novel ATPase isoform (hPMCA5)". Genome Res. 6 (6): 478-91. doi:10.1101/gr.6.6.478. PMID 8828037. Mallon AM, ...
SWISS-MODEL Repository entry for B3GZ69 (KTHY_ACTP7), Thymidylate kinase. Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Importance of Streptococci in the reproduction disorders OF THE MARE. NEW DATAS. The authors described the important intervention of Strepto coccus zooepidemicus, equi, equisimilis and uberis in the bacterial disorders of reproduction (fertility, endometritis) and causes of abortion. The principal bacterial pathogens causing disorders are : Streptococci, Escherichia coli, Klebsiella pneumoniae, Actinobacillus equuli, Salmonella typhimurium, Pseudomonas aeruginosa. The Streptococcal diseases are found in over 50 per cent of confirmed cases of bacterial disorders of reproduction. The bacterial contamination access to the vagina and uterus of the mares, often, during the breeding of foaling. The bacteriological controls of mares and stallions are necessary before breeding and the research of several bacterial organisms is obligatory ...
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Introduction. The incidence of infective endocarditis (IE) has increased over the past years as survival rates of patients with congenital heart disease improve.1 Main agents of IE are: (i) Viridans group Streptococci (S. milleri, S. mitior, S. salivarius, S. mutans and S. sanguis), mainly on patients with congenital heart disease; (ii) Staphylococcus aureus, generally associated with placement of central venous catheter and use of injecting drugs; (iii) Staphylococcus epidermidis, usually affecting patients following cardiac surgery and catheterized premature newborns.1 On the other hand, the HACEK group of bacteria (Haemophilus ssp, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens and Kingella kingae) is responsible for 3% of IE in adults.1-3 The objective of this study is to report a case of rare occurrence of IE caused by Haemophilus aphrophilus in a child. Report of case The patient was a 12-year-old boy with a 20-day history of fever accompanied by chills ...
Actinobacillus pleuropneumoniae (previously Haemophilus pleuropneumoniae), is a Gram-negative, facultative anaerobic, respiratory pathogen found in pigs. It was first reported in 1957, and was formally declared to be the causative agent of porcine pleuropneumonia in 1964. It was reclassified in 1983 after DNA studies showed it was more closely related to A. lignieresii. A. pleuropneumoniae is a nonmotile, Gram-negative, encapsulated coccobacillus bacterium found in the Pasteurellaceae family. It exhibits β-hemolysis activity, thus explaining its growth on chocolate or blood agar, but must be supplemented with NAD (V factor) to facilitate growth for one of its biological variants (biovar 1). As a facultative anaerobic pathogen, A. pleuropneumoniae may need CO2 to grow. Depending on the biovar, the bacteria may or may not be positive for urease; both biovars are positive for porphyrin. A. pleuropneumoniae was found to be the causative agent for up to 20% of all bacterial pneumonia cases in ...
Serotypes 3 and 8 of Actinobacillus pleuropneumoniae, the aetiological agent of porcine pleuropneumonia, have been reported to predominate in the UK. Direct serotyping of isolates of the organism is typically determined by the immunological reactivity of rabbit serum to its surface polysaccharides, but the method has limitations, for example, cross-reactions between serotypes 3, 6 and 8. This study describes the development of a serotype 3-specific PCR, based on the capsule locus, which can be used in a multiplex format with the organisms specific gene apxIV. The PCR test was evaluated on 266 strains of A pleuropneumoniae and 121 strains of other organisms, including all the major respiratory bacterial pathogens of pigs. The test was highly specific and sensitive and should be useful for differentiating strains of serotypes 3, 6 and 8, and in seroprevalence and epidemiological surveys in regions where serotype 3 is prevalent, such as the UK.. ...
Abstract Introduction Aggregatibacter aphrophilus formerly Haemophilus aphrophilus and H. Other infections reported in the literature include brain abscess, bone and joint infections and endophthalmitis.. There are only two cases of empyema ever reported due to this organism. We report the isolation of A. Case presentation A year-old female patient of Caucasian origin presented with a three-week history of fever, shortness of breath and dry cough. She was found to have a pleural empyema so a chest drain was inserted and a sample of pus was sent to the microbiology laboratory. They were oxidase- and catalase-negative. It was susceptible to amoxicillin, levofloxacin and doxycycline.. Our patient was treated with intravenous amoxicillin with clavulanic acid and clarithromycin followed by oral doxycycline, but was re-admitted twice over the next three months with recurrent empyema and the same organism was isolated.. Each episode was managed with chest drainage and a six-week course of ...
Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumonia, a significant disease that causes serious economic losses to the swine industry worldwide. Persistent infections caused by bacterial biofilms are recalcitrant to treat because of the particular drug resistance of biofilm-dwelling cells. TolC, a key component of multidrug efflux pumps, are responsible for multidrug resistance in many Gram-negative bacteria. In this study, we identified two TolC-like proteins, TolC1 and TolC2, in A. pleuropneumoniae. Deletion of tolC1, but not tolC2, caused a significant reduction in biofilm formation, as well as increased drug sensitivity of both planktonic and biofilm cells. The genetic-complementation of the tolC1 mutation restored the competent biofilm and drug resistance. Besides, biofilm formation was inhibited and drug sensitivity was increased by the addition of phenylalanine-arginine beta-naphthylamide (PAβN), a well-known efflux pump inhibitor (EPI), suggesting a role
Pleuropneumonia infectioasa a porcului (PIP), cauzata de Actinobacillus pleuropneumoniae (App), poate fi intalnita la porcii de toate varstele, inclusiv la mistreti, dar simptomele clinice cele mai frecvente sunt inregistrate la porcii in faza de finisare, in varsta de peste 12 saptamani. In formele clasice de boala animalele manifesta febra si simptome respiratorii, datorate leziunilor caracteristice de pneumonie hemoragico-necrotica sau pleuropneumonie fibrinoasa. Boala poate evolua supra-acut, fara semne clinice, animalele fiind gasite moarte, acut, mai ales in efectivele naive imunologic, cu pierderi prin mortalitate de 15-20%, sau sub-acut, cu mortalitate mai redusa dar variabila. In efectivele infectate endemic boala se cronicizeaza la animalele care au supravietuit, afectand starea lor de bine si producand o scadere a performantelor zootehnice. Porcii pot fi purtatori fara sa dezvolte vreun raspuns imun. Boala genereaza pierderi economice insemnate.. ...
The complete nucleotide sequence of a 7.7kb mobilisable plasmid (pM3446F), isolated from a florfenicol resistant isolate of Actinobacillus pleuropneumoniae, showed extended similarity to plasmids found in other members of the Pasteurellaceae containing the floR gene as well as replication and mobilisation genes. Mobilisation into other Pasteurellaceae species confirmed that this plasmid can be transferred horizontally ...
A preliminary study has been performed for the valorization of citrus peel waste (CPW) through the biorefinery platform aiming to produce succinic acid. Following extraction of essential oils and pectin, different conditions of dilute acid hydrolysis were evaluated based on estimation of the sugars liberated and subsequent fermentation of hydrolyzates for production of succinic acid by Actinobacillus succinogenes. The most suitable pretreatment conditions involved 116 degrees C for 10 min using 5% (w/v) of dry raw material (drm). Thus, a total sugar (ts) yield of 0.21 g(ts) g(drm)(-1) and a succinic acid (sa) yield via microbial fermentations of 0.77 g(sa) g(tsc)(-1) was achieved, while the use of lower solid contents resulted in higher sugar yields. The residues from dilute acid hydrolysis were applied for subsequent enzyme hydrolysis using commercial enzymes and the most suitable combination of enzyme units included 30 IU cellulases and 25 BGL beta-glucosidases achieving a yield of 0.58 g(ts) ...
Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Pharmacokinetic data were pooled for two bioequivalent products, pioneer and generic formulations, administered intramuscularly to pigs at a dose rate of 15 mg/kg. Antibacterial potency was determined in vitro as minimum inhibitory concentration (MIC) and Mutant Prevention Concentration in broth and pig serum, for six isolates of each organism. For both organisms and for both serum and broth MICs, average concentration:MIC ratios over 48 h were similar and exceeded 2.5:1 and times greater than MIC exceeded 35 h. From in vitro time-kill curves, PK/PD modelling established serum breakpoint values for the index AUC24h/MIC for three levels of inhibition of growth, bacteriostasis and 3 and 4log10 reductions in bacterial count; means were 25.7, 40.2 and 47.0 h, respectively, for P. multocida and 24.6,
ID C9R3L9_AGGAD Unreviewed; 404 AA. AC C9R3L9; DT 24-NOV-2009, integrated into UniProtKB/TrEMBL. DT 24-NOV-2009, sequence version 1. DT 25-OCT-2017, entry version 39. DE SubName: Full=Molybdopterin molybdenumtransferase {ECO:0000313,EMBL:ACX82405.1}; GN OrderedLocusNames=D11S_1018 {ECO:0000313,EMBL:ACX82405.1}; OS Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) OS (Actinobacillus actinomycetemcomitans). OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Aggregatibacter. OX NCBI_TaxID=668336 {ECO:0000313,EMBL:ACX82405.1, ECO:0000313,Proteomes:UP000002569}; RN [1] {ECO:0000313,EMBL:ACX82405.1, ECO:0000313,Proteomes:UP000002569} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=D11S-1 {ECO:0000313,EMBL:ACX82405.1, RC ECO:0000313,Proteomes:UP000002569}; RX PubMed=19820097; DOI=10.1128/JB.01203-09; RA Chen C., Kittichotirat W., Si Y., Bumgarner R.; RT "Genome sequence of Aggregatibacter actinomycetemcomitans serotype c RT strain D11S-1."; ...
Sneath, P. H. A.; Stevens, M. (1990). "Actinobacillus rossii sp. nov., Actinobacillus seminis sp. nov., nom. rev., Pasteurella ...
Sneath, P. H. A.; Stevens, M. (1990). "Actinobacillus rossii sp. nov., Actinobacillus seminis sp. nov., nom. rev., Pasteurella ... Actinobacillus] rossii and [Pasteurella] mairii". Veterinary Microbiology. 116 (1-3): 194-201. doi:10.1016/j.vetmic.2006.03.003 ... Actinobacillus] rossii". International Journal of Systematic and Evolutionary Microbiology. 55 (Pt 1): 209-223. doi:10.1099/ijs ...
Various studies have associated Aggregatibacter actinomycetemcomitans, formerly known as Actinobacillus actinomycetemcomitans, ... Fives-Taylor, P. M.; Meyer, D. H.; Mintz, K. P.; Brissette, C. (June 1999). "Virulence factors of Actinobacillus ... High levels of Aggregatibacter (or Actinobacillus) actinomycetemcomitans and, in some populations, Porphyromonas gingivalis.[15 ... Zambon, J. J.; Christersson, L. A.; Slots, J. (December 1983). "Actinobacillus actinomycetemcomitans in human periodontal ...
One of the most common forms seen by veterinarians is mouth actinobacillosis of cattle, due to Actinobacillus lignieresii. The ... Actinobacillosis is a zoonotic disease caused by Actinobacillus. It is more commonly associated with animals than with humans. ... The infection is most commonly caused by abrasions on different soft tissues through which the bacteria, Actinobacillus ... actinomycosis Actinobacillus suis "Merck Veterinary Manual". "Dorlands Medical Dictionary:actinobacillosis". "Actinobacillosis ...
See at publisher McKinlay, J. B.; Zeikus, J. G.; Vieille, C. (2005). "Insights into Actinobacillus succinogenes Fermentative ... Microbial production of Succinic acid can be performed with wild bacteria like Actinobacillus succinogenes, Mannheimia ... van Heerden, C.D.; Nicol, W. (2013). "Continuous succinic acid fermentation by Actinobacillus succinogenes". Biochemical ...
... (previously Actinobacillus actinomycetemcomitans) is a Gram-negative, facultative ... It was reclassified as Actinobacillus actinomycetemcomitans by Topley & Wilson (1929) and as Haemophilus actinomycetemcomitans ... Nørskov-Lauritsen N; Kilian M (September 2006). "Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus ... Actinobacillus) actinomycetemcomitans: a triple A* periodontopathogen?". Periodontology 2000. 54 (1): 78-105. doi:10.1111/j. ...
Kaplan JB, Ragunath C, Ramasubbu N, Fine DH (August 2003). "Detachment of Actinobacillus actinomycetemcomitans biofilm cells by ... Kaplan JB, Meyenhofer MF, Fine DH (2003). "Biofilm growth and detachment of Actinobacillus actinomycetemcomitans". J. Bacteriol ... a biofilm-releasing glycoside hydrolase from the periodontopathogen Actinobacillus actinomycetemcomitans". J. Mol. Biol. 349 (3 ... "Poly-N-acetylglucosamine mediates biofilm formation and antibiotic resistance in Actinobacillus pleuropneumoniae". Microb ...
"Comparison of Two Selective Media for Actinobacillus actinomycetemcomitans." J Clin Microbiol 1986;24:636-638. Fryman A, ... Slots is responsible for discovering the role of Aggregatibacter actinomycetemcomitans (previously Actinobacillus ...
"Comparison of Two Selective Media for Actinobacillus actinomycetemcomitans." J Clin Microbiol 1986;24:636-638. Slots, J. " ... "Selective medium for isolation of Actinobacillus actinomycetemcomitans." J Clin Microbiol 1982;15:606-609.. ...
Actinobacillus actinomycetemcomitans is considered an oral pathogen due to its virulence factors, its association with ... 2008). "Molecular Windows into the Pathogenic Properties of Actinobacillus actinomycetemcomitans". Molecular Oral Microbiology ...
These bacteria include Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillus actinomycetemcomitans. Healthy ...
Actinobacillus pleuropneumonia and Salmonella infections in pigs. Vaccine development has several trends: Until recently,[when ... "Development of a DIVA subunit vaccine against Actinobacillus pleuropneumoniae infection". Vaccine. 24 (49): 7226-32. doi: ...
This study found that LJP was highly associated with Actinobacillus actinomycetemcomitans.[citation needed] Lopez 2001 examined ...
"Inactivation of DNA adenine methyltransferase alters virulence factors in Actinobacillus actinomycetemcomitans". Oral ...
Actinobacillus spp., Aeromonas salmonicida, Alcaligenes sp., most Bacillus sp., Bordetella sp., Enterobacter sp., most ...
Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae are pathogens that cause respiratory disease in swine. Haemophilus ... Escherichia coli TOP10 strain Campylobacter jejuni Mycoplasma hyopneumoniae Haemophilus influenzae Actinobacillus ...
Nørskov-Lauritsen, N.; Kilian, M. (2006). "Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, ... Nørskov-Lauritsen, N.; Kilian, M. (2006). "Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, ... "Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus ...
... while the other includes Actinobacillus minor, Actinobacillus pleuropneumoniae, Haemophilus ducreyi, Haemophilus parasuis, and ... The distribution of CSIs corresponds to sensu stricto clades of "true" Actinobacillus, Haemophilus, and Pasteurella species, ... and Actinobacillus species. Comparative analyses of Pasteurellaceae genomes have identified large numbers (>20) of conserved ... Actinobacillus, Haemophilus, and Pasteurella. These genera demonstrate extensive polyphyly across the family, however, CSIs ...
HACEK originally referred to Haemophilus parainfluenzae, Haemophilus aphrophilus, Actinobacillus actinomycetemcomitans, ... previously Actinobacillus), Cardiobacterium, Eikenella, Kingella. The HACEK organisms are a normal part of the human microbiota ... previously Actinobacillus actinomycetemcomitans) Aggregatibacter segnis Aggregatibacter aphrophilus (previously Haemophilus ...
"Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus ...
"Development of a DIVA subunit vaccine against Actinobacillus pleuropneumoniae infection". Vaccine. 24 (49-50): 7226-37. doi: ... Actinobacillus pleuropneumonia[111] and Salmonella infections in pigs.[112] ...
Clade II, encompassing Actinobacillus pleuropneumoniae, Actinobacillus minor, Haemophilus ducreyi, Mannheimia haemolytica and ... Two major clades are formed within this Pasteurellales: Clade I, encompassing Aggregatibacter, Pasteurella, Actinobacillus ...
... reducing pig deaths and disease from the bacteria Actinobacillus pleuropneumoniae. The Molecular Plant Breeding CRC developed ...
Actinobacillus, Cardiobacterium, Eikenella, and Kingella organisms: a retrospective multicenter evaluation". J. Clin. Microbiol ...
Dedkov VS, Degtyarev SK (April-May 1998). "Actinobacillus and Streptococcus: producers of isoschizomers of the restriction ...
Actinobacillus pleuropneumoniae ATCC ® 33590™ Designation: Femo TypeStrain=True Application: Characterization Respiratory ... Actinobacillus pleuropneumoniae (Shope) Pohl et al. (ATCC® 33590™) Strain Designations: Femo / Type Strain: yes / Biosafety ... Analysis of Actinobacillus pleuropneumoniae and related organisms by DNA-DNA hybridization and restriction endonuclease ...
The main causative organism of this disease is Actinobacillus … ... The main causative organism of this disease is Actinobacillus ... Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans Annu Rev Microbiol. 2003;57:29- ...
Natural Transformation and DNA Uptake Signal Sequences in Actinobacillus actinomycetemcomitans. Ying Wang, Steve D. Goodman, ... Natural Transformation and DNA Uptake Signal Sequences in Actinobacillus actinomycetemcomitans. Ying Wang, Steve D. Goodman, ... Natural Transformation and DNA Uptake Signal Sequences in Actinobacillus actinomycetemcomitans. Ying Wang, Steve D. Goodman, ... Actinobacillus actinomycetemcomitans is a member of the family Pasteurellaceae and a major causative agent of periodontitis. ...
... an antigenic membrane protein from Actinobacillus pleuropnemoniae homology to ABC transporters; amino acid sequence in first ... Actinobacillus pleuropneumoniae ApaA protein. Subscribe to New Research on Actinobacillus pleuropneumoniae ApaA protein ... an antigenic membrane protein from Actinobacillus pleuropnemoniae homology to ABC transporters; amino acid sequence in first ...
Actinobacillus actinomycetemcomitans, an oral bacterium implicated in the etiology of periodontal diseases, produces a ... Caspase 1 involvement in human monocyte lysis induced by Actinobacillus actinomycetemcomitans leukotoxin. Kelk, Peyman Umeå ... Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis ...
Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumonia, a significant disease that causes ... Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumonia, a significant disease that causes ... FIGURE 1. Location of TolC1 and TolC2 of Actinobacillus pleuropneumoniae in the TolC family phylogenetic tree. The TolC ... 2002). Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection. Microbes Infect. 4, 225-235. doi: 10.1016/ ...
... we commented on a general rise in the frequency of Actinobacillus suis (A. suis) isolation from our swine tissue submission ... Actinobacillus suis Activity Persists. A little over two years ago, we commented on a general rise in the frequency of ... A little over two years ago, we commented on a general rise in the frequency of Actinobacillus suis (A. suis) isolation from ... The main concern with Actinobacillus suis, however, is sudden deaths in finishing pigs and adult breeding animals due to ...
MUNOZ, D; QUEZADA, M y RUIZ, A. Serological behaviour study of Actinobacillus pleuropneumoniae (App) in commercial swine herds ... Palabras clave : Actinobacillus pleuropneumoniae; seroprevalence; seroconversion. · resumen en Español · texto en Español · ...
Isolation of Actinobacillus pleuropneumoniae serotype 2 by immunomagnetic separation. Publication: Research - peer-review › ... In Denmark porcine pleuropneumonia is most frequently caused by Actinobacillus pleuropneumoniae serotype 2 (60%). Isolation of ...
... Freddy ... "Actinobacillus Pleuropneumoniae Infections in Pigs: The Role of Virulence Factors in Pathogenesis and Protection." Veterinary ... "Actinobacillus Pleuropneumoniae Infections in Pigs: The Role of Virulence Factors in Pathogenesis and Protection." VETERINARY ... Haesebrouck F, Chiers K, Van Overbeke I, Ducatelle R. Actinobacillus pleuropneumoniae infections in pigs: the role of virulence ...
zinc, antibiotics, Actinobacillus pleuropneumoniae, pigs, haptoglobin, Ab alpha-tocopherol, interleukin-6, biomarkers, C- ... Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae ... possible role as evaluators of antibiotic treatment in an aerosol infection model of porcine pneumonia caused by Actinobacillus ...
Seroprevalence of Actinobacillus pleuropneumoniae serovars 2, 3 and 9 in slaughter pigs from Belgian fattening farms ... Seroprevalence of Actinobacillus pleuropneumoniae serovars 2, 3 and 9 in slaughter pigs from Belgian fattening farms ... selected fattening pig herds were studied to investigate the epidemiological characteristics of infections with Actinobacillus ...
title = "Actinobacillus pleuropneumoniae serotypes in Hungary",. abstract = "A total of 255 Actinobacillus pleuropneumoniae ... Actinobacillus pleuropneumoniae serotypes in Hungary. / Sárközi, Rita; Makrai, L.; Fodor, L.. In: Acta Veterinaria Hungarica, ... Sárközi, Rita ; Makrai, L. ; Fodor, L. / Actinobacillus pleuropneumoniae serotypes in Hungary. In: Acta Veterinaria Hungarica. ... Sárközi, R., Makrai, L., & Fodor, L. (2018). Actinobacillus pleuropneumoniae serotypes in Hungary. Acta Veterinaria Hungarica, ...
Serotypes 3 and 8 of Actinobacillus pleuropneumoniae, the aetiological agent of porcine pleuropneumonia, have been reported to ... PCR specific for Actinobacillus pleuropneumoniae serotype 3. VETERINARY RECORD, 162 (20). 648-+. ...
Actinobacillus pleuropneumoniae serotype 3 UPF0263 protein APJL_1366 (APJL_1366) datasheet and description hight quality ... Actinobacillus pleuropneumoniae serotype 3 UPF0263 protein APJL_1366 (APJL_1366). Short name: Actinobacillus pleuropneumoniae ... Actinobacillus pleuropneumoniae serotype 3 UPF0263 protein APJL_1366 (APJL_1366). Contact us. ... Recombinant Actinobacillus pleuropneumoniae serotype 3 UPF0263 protein APJL_1366 (APJL_1366). Alternative names: UPF0263 ...
Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillus actinomycetemcomitans serotypes ... 13C-NMR; 1H-NMR; 6-deoxy-L-talose; Actinobacillus actinomycetemcomitans; Antigens; bacterial; Canada; chemical; chemistry; D- ... [email protected]: Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillus actinomycetemcomitans ... Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillus actinomycetemcomitans serotypes ...
0004] It is commonly known how to produce the RTX-toxin ApxI by culturing Actinobacillus pleuropneumoniae in a culturing medium ... 1. A method to produce RTX-toxin ApxI comprising culturing Actinobacillus pleuropneumoniae bacteria in a culturing medium that ... Without NAD, the medium will not support growth of the Actinobacillus pleuropneumoniae bacteria and can thus not be considered ... The present invention pertains to a method to produce RTX-toxin Apxl by culturing Actinobacillus pleuropneumonica bacteria in a ...
Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical isolate PO ... [email protected]: Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical ... Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical isolate PO ... Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical isolate PO ...
Pasteur > Noutati > Un nou test PCR pentru detectia Actinobacillus pleuropneumoniae in probele biologice prelevate de la suine ... Un nou test PCR pentru detectia Actinobacillus pleuropneumoniae in probele biologice prelevate de la suine este disponibil in ... Un nou test PCR pentru detectia Actinobacillus pleuropneumoniae in probele biologice prelevate de la suine este disponibil in ... Un nou test PCR pentru detectia Actinobacillus pleuropneumoniae in probele biologice prelevate de la suine este disponibil in ...
An unstructured kinetic model for the growth of Actinobacillus succinogenes on glycerol as the only carbon source is proposed ... N2 - An unstructured kinetic model for the growth of Actinobacillus succinogenes on glycerol as the only carbon source is ... AB - An unstructured kinetic model for the growth of Actinobacillus succinogenes on glycerol as the only carbon source is ... abstract = "An unstructured kinetic model for the growth of Actinobacillus succinogenes on glycerol as the only carbon source ...
Actinobacillus lignieresii infects cattle and sheep while A. equuli infects horses and pigs. ...
HACEK originally referred to Haemophilus parainfluenzae, Haemophilus aphrophilus, Actinobacillus actinomycetemcomitans, ... previously Actinobacillus), Cardiobacterium, Eikenella, Kingella. The HACEK organisms are a normal part of the human microbiota ... previously Actinobacillus actinomycetemcomitans) Aggregatibacter segnis Aggregatibacter aphrophilus (previously Haemophilus ...
Actinobacillus pleuropneumoniae Medicine & Life Sciences * surface antigens Agriculture & Biology * Surface Antigens Medicine ...
... caused by Actinobacillus pleuropneumoniae, is a bacterial respiratory disease of swine. Acute outbreaks of the disease are ... Li Y, Cao S, Zhang L, GW Lau Y, Wen RW, Zhao Q, Huang X, Yan Q, Huang Y, Wen X. A TolC-like protein of Actinobacillus ... Gottschalk M. Actinobacillus pleuropneumoniae: an old but still relevant swine pathogen in the XXI century. In: Proc 22nd ... Porcine pleuropneumonia is a respiratory disease caused by the gram-negative bacterium Actinobacillus (A.) pleuropneumoniae. ...
It is caused by Actinobacillus lignieresii, part of the normal bacterial flora of the upper digestive tract. ... It is caused by Actinobacillus lignieresii, part of the normal bacterial flora of the upper digestive tract. The bacteria ...
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