Actinium. A trivalent radioactive element and the prototypical member of the actinide family. It has the atomic symbol Ac, atomic number 89, and atomic weight 227.0278. Its principal isotope is 227 and decays primarily by beta-emission.
Thorium. A radioactive element of the actinide series of metals. It has an atomic symbol Th, atomic number 90, and atomic weight 232.04. It is used as fuel in nuclear reactors to produce fissionable uranium isotopes. Because of its radioopacity, various thorium compounds are used to facilitate visualization in roentgenography.

Preparation of alpha-emitting 213Bi-labeled antibody constructs for clinical use. (1/23)

Preclinical evaluation of alpha particle-emitting 213Bi-labeled antibody constructs have demonstrated the specificity and potency of these agents in a variety of cancer systems. The transition of a 213Bi-radiolabeled antibody from a preclinical construct to a clinical drug represented a difficult task that involved development of reliable and validated methods to provide multiple MBq quantities of a pure, immunoreactive agent that met pharmaceutical standards to treat patients. METHODS: The methods used for the preparation of (213Bi)CHX-A-diethylenetriamine pentaacetic acid (DTPA)-HuM195, an alpha particle-emitting anti-CD33 antibody construct for therapy of myeloid leukemias, is used as a specific example. This article describes methods for reagent purification, drug labeling, radioprotection and chromatographic purification. Quality of the drug is evaluated using radiochemical incorporation and purity assays with instant thin-layer chromatography (ITLC) and high-performance liquid chromatography (HPLC), determination of cell-based antibody total immunereactivity, small animal safety, pyrogen level, sterility and radionuclidic purity. RESULTS: Sixty-seven doses were prepared. Individual doses ranged from 148 to 814 MBq. Specific activities ranged from 329 to 766 MBq/mg. The radiolabeling efficiency (median +/- SD) of CHX-A-DTPA-HuM195 with 213Bi was 81% +/- 9% (n = 67) after 9 min. The construct was purified by size-exclusion chromatography and was found to be 99% +/- 2% pure (n = 67) by either ITLC or HPLC methods. The immunoreactivity of (213Bi)CHX-A-DTPA-HuM195 was 89% +/- 9% (n = 44) and was independent of the specific activity. The formulated pharmaceutical was found to contain < or =4 +/- 1 EU/mL pyrogens (n = 66); all samples examined were sterile. An 225Ac radionuclidic impurity was present at a level of 0.04 +/- 0.03 x 10(-6)/mL (n = 10) in a product volume of 7.4 +/- 0.5 mL (n = 67). Each of the 67 doses was injected intravenously into patients without complication as part of a phase I clinical trial. CONCLUSION: These data show that 213Bi-labeled antibody constructs can be prepared and administered safely to humans at a wide range of therapeutic levels.  (+info)

Tumor therapy with targeted atomic nanogenerators. (2/23)

A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to target molecular-sized generators of alpha-emitting isotope cascades to the inside of cancer cells using actinium-225 coupled to internalizing monoclonal antibodies. In vitro, these constructs specifically killed leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate cancer cells at becquerel (picocurie) levels. Injection of single doses of the constructs at kilobecquerel (nanocurie) levels into mice bearing solid prostate carcinoma or disseminated human lymphoma induced tumor regression and prolonged survival, without toxicity, in a substantial fraction of animals. Nanogenerators targeting a wide variety of cancers may be possible.  (+info)

Targeted actinium-225 in vivo generators for therapy of ovarian cancer. (3/23)

Advanced ovarian cancer is largely incurable, but initially it is frequently confined to the i.p. space. We explored i.p. radioimmunotherapy in a mouse model of human ovarian cancer. Use of a targeted actinium-225 ((225)Ac) in vivo generator of alpha particles exploits the extreme, selective cytotoxicity of alpha particles, while providing a feasible half-life to enable delivery to tumor. (225)Ac chelated with 2-(p-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10 tetraacetic acid was conjugated to trastuzumab, an anti-HER-2/neu antibody. The radioimmunoconjugate was tested for immunoreactivity, internalization, and cytotoxicity using a human ovarian carcinoma cell line, SKOV3. (225)Ac-labeled trastuzumab retained immunoreactivity (50-90%), rapidly internalized into cells (50% at 2 h), and had an ED(50) of 1.3 nCi/ml after 4 days of incubation in vitro. i.p. administered (225)Ac- or (111)In-labeled trastuzumab behaved similarly with high tumor uptake [56-60% injected dose per gram (% ID/g) at 4 h, which increased to 65-70% ID/g at 24 h]. Tumor uptake was 3-5-fold higher than liver and spleen, the normal organs with the highest uptake. i.v. administration of (111)In-labeled trastuzumab produced slightly higher normal organ uptake compared with i.p.-administered (111)In-labeled trastuzumab. However, tumor uptake was low, 5%-26% ID/g. Therapy was examined with native trastuzumab and 220, 330, and 450 nCi of (225)Ac-labeled trastuzumab or (225)Ac-labeled control antibody at different dosing schedules. Therapy was initiated 9 days after tumor seeding. Groups of control mice and those administered native trastuzumab had median survivals of 33 and 37 or 44 days, respectively. Median survival was 52-126 days with (225)Ac-labeled trastuzumab at various doses and schedules, and 48-64 days for (225)Ac-labeled control the same schedules. Deaths from toxicity occurred with the highest activity levels. In conclusion, i.p. administration with a (225)Ac-labeled internalizing anti-HER-2/neu antibody can extend survival significantly in a nude mouse model of human ovarian cancer at levels that produce no apparent gross toxicity.  (+info)

Pharmacokinetics, dosimetry, and toxicity of the targetable atomic generator, 225Ac-HuM195, in nonhuman primates. (4/23)

Short-lived alpha-emitting isotopes individually conjugated to monoclonal antibodies have now reached human use, but little is still known about their toxicity. Use of antibody targetable (225)Ac nanogenerators is a new approach in the field of alpha-immunotherapy offering the advantage of a 10-d half-life (t(1/2)) and increased potency due to generation of 3 new atoms, yielding a total of 4 alpha-particles. However, the 3 alpha-emitting daughter elements generated have the potential for significant toxicity as these nuclides are no longer bound to the carrier IgG. METHODS: Cynomolgus monkeys were used to evaluate the toxicity of prototype (225)Ac nanogenerators. Monoclonal antibody HuM195 (anti-CD33) is the carrier for planned human clinical trials of (225)Ac; there are no CD33 sites in cynomolgus monkeys. In one experiment, 2 monkeys received a single intravenous dose of (225)Ac-HuM195 at 28 kBq/kg. This dose level is approximately the planned initial human dose. In another experiment, 2 animals received a dose escalation schedule of 3 increasing (225)Ac-HuM195 doses with a cumulative activity of 377 kBq/kg. The whole-blood t(1/2) of (225)Ac, ratios of (225)Ac to its ultimate alpha-emitting daughter nuclide (213)Bi, generation of monkey anti-HuM195 antibodies (MAHA), hematologic indices, serum biochemistries, and clinical parameters were measured. Monkeys were euthanized and examined histopathologically when the dose escalation reached toxicity. RESULTS: The blood t(1/2) of (225)Ac-HuM195 was 12 d, and 45% of generated (213)Bi daughters were cleared from the blood. MAHA production was not detected. Approximately 28 kBq/kg of (225)Ac caused no toxicity at 6 mo, whereas a cumulative dose of approximately 377 kBq/kg caused severe toxicity. In the cumulative dosing schedule, single doses of approximately 37 kBq/kg resulted in no toxicity at 6 wk. After approximately 130 kBq/kg were administered, no toxicity was observed for 13 wk. However, 28 wk after this second dose administration, mild anemia and increases of blood urea nitrogen and creatinine were detected. After administration of an additional 185 kBq/kg, toxicity became clinically apparent. Monkeys were euthanized 13 and 19 wk after the third dose administration (cumulative dose was 377 kBq/kg). Histopathologic evaluation revealed mainly renal tubular damage associated with interstitial fibrosis. CONCLUSION: (225)Ac nanogenerators may result in renal toxicity and anemia at high doses. The longer blood t(1/2) and the lack of target cell antigens in cynomolgus monkeys may increase toxicity compared with human application. Therefore, a dose level of at least 28 kBq/kg may be a safe starting dose in humans. Hematologic and renal function will require close surveillance during clinical trials.  (+info)

Engineered liposomes for potential alpha-particle therapy of metastatic cancer. (5/23)

Disseminated, metastatic cancer is frequently incurable. Targeted alpha-particle emitters hold great promise as therapeutic agents for disseminated disease. (225)Ac is a radionuclide generator that has a 10-d half-life and results in alpha-emitting daughter elements ((221)Fr, (217)At, (213)Bi) that lead to the emission of a total of 4 alpha-particles. The aim of this study was to develop approaches for stable and controlled targeting of (225)Ac to sites of disseminated tumor metastases. Liposomes with encapsulated (225)Ac were developed to retain the potentially toxic daughters at the tumor site. METHODS: (225)Ac was passively entrapped in liposomes. To experimentally test the retention of actinium and its daughters by the liposomes, the gamma-emissions of (213)Bi were measured in liposome fractions, which were separated from the parent liposome population and the free radionuclides, at different times. Under equilibrium conditions the decay rate of (213)Bi was used to determine the concentration of (225)Ac. Measurements of the kinetics of (213)Bi activity were performed to estimate the entrapment of (213)Bi, the last alpha-emitting daughter in the decay chain. RESULTS: Stable pegylated phosphatidylcholine-cholesterol liposomes of different sizes and charge were prepared. Multiple (more than 2) (225)Ac atoms were successfully entrapped per liposome. (225)Ac retention by zwitterionic liposomes was more than 88% over 30 d. Retention by cationic liposomes was lower. A theoretical calculation showed that for satisfactory (213)Bi retention (>50%), liposomes of relatively large sizes (>650 nm in diameter) are required. (213)Bi retention was experimentally verified to be liposome-size dependent. For large liposomes, the measured (213)Bi retention was lower than theoretically predicted (less than 10%). CONCLUSION: This work supports the hypothesis that it may be possible to develop (225)Ac-based therapies by delivering multiple (225)Ac atoms in liposomes. Improvements in the retention of (225)Ac daughters will likely be necessary to fulfill this potential. Because of the size of the liposomal structures required to contain the daughters, the approach is ideally suited for locoregional therapy (e.g., intraperitoneal, intrahepatic artery, or intrathecal).  (+info)

Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents. (6/23)

The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.  (+info)

Alpha-particle emitting atomic generator (Actinium-225)-labeled trastuzumab (herceptin) targeting of breast cancer spheroids: efficacy versus HER2/neu expression. (7/23)

PURPOSE: The humanized monoclonal antibody, trastuzumab (Herceptin), directed against HER2/neu, has been effective in the treatment of breast cancer malignancies. However, clinical activity has depended on HER2/neu expression. Radiolabeled trastuzumab has been considered previously as a potential agent for radioimmunotherapy. The objective of this study was to investigate the efficacy of trastuzumab labeled with the alpha-particle emitting atomic generator, actinium-225 ((225)Ac), against breast cancer spheroids with different HER2/neu expression levels. (225)Ac has a 10-day half-life and a decay scheme yielding four alpha-particles. EXPERIMENTAL DESIGN: The breast carcinoma cell lines MCF7, MDA-MB-361 (MDA), and BT-474 (BT) with relative HER2/neu expression (by flow cytometry) of 1:4:18 were used. Spheroids of these cell lines were incubated with different concentrations of (225)Ac-trastuzumab, and spheroid growth was measured by light microscopy over a 50-day period. RESULTS: The activity concentration required to yield a 50% reduction in spheroid volume at day 35 was 18.1, 1.9, and 0.6 kBq/ml (490, 52, 14 nCi/ml) for MCF7, MDA, and BT spheroids, respectively. MCF7 spheroids continued growing but with a 20-30 day growth delay at 18.5 kBq/ml. MDA spheroid growth was delayed by 30-40 days at 3.7 kBq/ml; at 18.5 kBq/ml, 12 of 12 spheroids disaggregated after 70, days and cells remaining from each spheroid failed to form colonies within 2 weeks of being transferred to adherent dishes. Eight of 10 BT spheroids failed to regrow at 1.85 kBq/ml. All of the BT spheroids at activity concentrations 3.7 kBq/ml failed to regrow and to form colonies. The radiosensitivity of these three lines as spheroids was evaluated as the activity concentration required to reduce the treated to untreated spheroid volume ratio to 0.37, denoted DVR(37). An external beam radiosensitivity of 2 Gy was found for spheroids of all three of the cell lines. After alpha-particle irradiation a DVR(37) of 1.5, 3.0, and 2.0 kBq/ml was determined for MCF7, MDA, and BT, respectively. CONCLUSION: These studies suggest that (225)Ac-labeled trastuzumab may be a potent therapeutic agent against metastatic breast cancer cells exhibiting intermediate to high HER2/neu expression.  (+info)

Treatment of neuroblastoma meningeal carcinomatosis with intrathecal application of alpha-emitting atomic nanogenerators targeting disialo-ganglioside GD2. (8/23)

Labeling of specific antibodies with bifunctional chelated Actinium-225 ((225)Ac; an alpha generator) allows the formation of new, highly potent and selective alpha-emitting anticancer drugs. We synthesized and evaluated a radioimmunoconjugate based on 3F8, an IgG(3) antibody that specifically binds to ganglioside GD2, which is overexpressed by many neuroectodermal tumors including neuroblastoma. The (225)Ac-1,4,7,10-tetra-azacylododecane (DOTA)-3F8 construct was evaluated for radiochemical purity and sterility, immunoreactivity, cytotoxicity in vitro, induction of apoptosis on GD2-positive cells, as well as for pharmacological biodistribution and metabolism of the (225)Ac generator and its daughters in a nude mouse xenograft model of neuroblastoma. The (225)Ac-3F8 showed an IC(50) of 3 Bq/ml (80 pCi/ml) on the neuroblastoma cell line, NMB7, in vitro. Apoptosis of these cells was not observed. Biodistribution in mice showed specific targeting of a subcutaneous tumor; there was redistribution of the (225)Ac daughter nuclides mainly from blood to kidneys and to small intestine. Toxicity was examined in cynomolgus monkeys. Monkeys injected with 1 to 3 doses of intrathecal (225)Ac-3F8 radioimmunoconjugate (80 to 150 kBq/kg total dose) did not show signs of toxicity based on blood chemistry, complete blood counts, or by clinical evaluations. Therapeutic efficacy of intrathecal (225)Ac-3F8 was studied in a nude rat xenograft model of meningeal carcinomatosis. The (225)Ac-3F8 treatment improved survival 2-fold from 16 to 34 days (P = 0.01). In conclusion, in vivo alpha generators targeted by 3F8 warrant additional study as a possible new approach to the treatment of carcinomatous meningitis.  (+info)

Actinium is a naturally occurring radioactive metallic element with the symbol Ac and atomic number 89. It was discovered in 1899 by André-Louis Debierne, a French chemist, who isolated it from uranium ore. Actinium is one of the actinides, a series of elements in the periodic table that are characterized by their radioactivity and their position in the f-block of the periodic table.

Actinium has no biological role in humans or other organisms, and exposure to its radiation can be harmful. It is not found in significant quantities in the environment, but it can be produced artificially through nuclear reactions. Actinium has a few potential medical applications, including as a component of radioactive compounds used for cancer treatment. However, its use in medicine is limited due to its radioactivity and toxicity.

Thorium is not a medical term, but it is a chemical element with symbol Th and atomic number 90. It's a naturally occurring, slightly radioactive metal that is found in small amounts in soil, rocks, and water. While thorium has no direct medical applications or definitions, it is worth noting that it has been studied for its potential use in nuclear medicine due to its alpha-emitting properties. However, the use of thorium in medical applications remains highly experimental and not widely adopted.

The isotopes of actinium range in atomic weight from 204 u (204 Ac) to 236 u (236 Ac). Actinium is found only in traces in ... Actinium gave the name to the actinide series, a set of 15 elements between actinium and lawrencium in the periodic table. ... The actinium isotope 227Ac is a transient member of the uranium-actinium series decay chain, which begins with the parent ... Actinium metal has been prepared by the reduction of actinium fluoride with lithium vapor in vacuum at a temperature between ...
... is an inorganic compound, with the chemical formula AcOF. It is radioactive. It crystallises in a calcium ... It can be obtained by reacting actinium fluoride with ammonia and water: AcF3 + 2 NH3 + H2O → AcOF + 2 NH4F The reaction ... "The Preparation and Identification of Some Pure Actinium Compounds 1". Journal of the American Chemical Society. 72 (2): 771- ...
... (225Ac, Ac-225) is an isotope of actinium. It undergoes alpha decay to francium-221 with a half-life of 10 days, ... Actinium-225 has a half-life of 10 days and decays by alpha emission. It is part of the neptunium series, for it arises as a ... Actinium-225 was discovered in 1947 as part of the hitherto unknown neptunium series, which was populated by the synthesis of ... Isotopes of actinium Radium-223 Audi, G.; Kondev, F. G.; Wang, M.; Huang, W. J.; Naimi, S. (2017). "The NUBASE2016 evaluation ...
... is a species of sea snail, a marine gastropod mollusk in the family Cerithiidae. Cerithidium actinium ...
Actinium(III) oxide is the only oxide that actinium can form, with the chemical formula Ac2O3. In this compound, actinium is in ... Actinium compounds are compounds containing the element actinium (Ac). Due to actinium's intense radioactivity, only a limited ... Actinium hydride was obtained by reduction of actinium trichloride with potassium at 300 °C, and its structure was deduced by ... Farr, J.; Giorgi, A. L.; Bowman, M. G.; Money, R. K. (1961). "The crystal structure of actinium metal and actinium hydride". ...
... , Actinium, Lists of isotopes by element). ... Actinium (89Ac) has no stable isotopes and no characteristic ... 228Ac and 225Ac are extremely rare, so almost all natural actinium is 227Ac. The most stable isotopes are 227Ac with a half- ... Plus radium (element 88). While actually a sub-actinide, it immediately precedes actinium (89) and follows a three-element gap ... of heavy neutron-rich isotopes with time-resolved Schottky spectrometry in the element range from thallium to actinium" (PDF). ...
... is the radioactive compound of actinium with the formula Ac2S3. This salt was prepared by heating ... The result was conformed to be actinium(III) sulfide by x-ray diffraction. "Diactinium trisulphide". WebElements. Retrieved 16 ... the University of Michigan (1948). The Preparation of Actinium Compounds. U.S. Atomic Energy Commission, Technical Information ... actinium(III) oxalate at 1400°C for 6 minutes in a mixture of carbon disulfide and hydrogen sulfide. ...
Actinium nitrate can be obtained by dissolving actinium or actinium hydroxide in nitric acid. A c ( O H ) 3 + 3 H N O 3 → A c ... Actinium(III) nitrate is an inorganic compound, actinium salt of nitric acid with the chemical formula Ac(NO3)3. The compound ... Salutsky, M. L.; Kirby, H. W. (1 November 1956). "Precipitation of Actinium Oxalate from Homogeneous Solution". Analytical ... N O 3 ) 3 + 3 H 2 O {\displaystyle {\mathsf {Ac(OH)_{3}+3HNO_{3}\ \xrightarrow {} \ Ac(NO_{3})_{3}+3H_{2}O}}} Actinium(III) ...
... is a chemical compound containing the rare radioactive element actinium. This salt has the formula AcCl3 ... Actinium(III) chloride is made by reacting actinium hydroxide with carbon tetrachloride. 4 Ac(OH)3 + 3 CCl4 → 4AcCl3 + 3CO2 + ... "WebElements Periodic Table » Actinium » actinium trichloride". www.webelements.com.{{cite web}}: CS1 maint: multiple names: ... "Actinium chloride". pubchem.ncbi.nlm.nih.gov. v t e (CS1 maint: multiple names: authors list, Articles without InChI source, ...
... is a white-colored chemical compound of the radioactive element actinium. This compound was created by ... the University of Michigan (1948). The Preparation of Actinium Compounds. U.S. Atomic Energy Commission, Technical Information ... reacting actinium(III) chloride with monosodium phosphate in aqueous hydrochloric acid. This resulted in the hemihydrate AcPO4· ...
... is a chemical compound containing the rare radioactive element actinium. It has the formula Ac2O3. It is ... Actinium, Great Soviet Encyclopedia (in Russian) Sherman, Fried; Hagemann, French; Zachariasen, W. H. (1950). "The Preparation ... Actinium oxide is not to be confused with Ac2O (acetic anhydride), where Ac is an abbreviation for acetyl instead of the symbol ... Actinium compounds, Sesquioxides, All stub articles, Inorganic compound stubs). ...
... is a radioactive white crystalline solid that is a salt of actinium. It is prepared by reacting actinium( ... it turns into actinium oxybromide. "Actinium tribromide". WebElements. Retrieved 15 April 2021. Zachariasen, W. H. (1948). " ...
... is the a salt of the radioactive metal actinium. It is a white crystalline solid. This compound was made ... "Actinium triiodide". WebElements. Retrieved 16 April 2021. the University of Michigan (1948). The Preparation of Actinium ... Actinium compounds, Iodides, All stub articles, Inorganic compound stubs). ... by heating actinium oxide with a mixture of aluminium metal and iodine at 700 °C for two hours. " ...
... (AcF3) is an inorganic compound, a salt of actinium and fluorine. Actinium fluoride can be prepared in ... Actinium fluoride is a white solid that reacts with ammonia at 900-1000 °C to yield an actinium oxyfluoride: AcF 3 + 2 NH 3 + H ... In the first method, actinium hydroxide is treated with hydrofluoric acid and the product precipitates: Ac ( OH ) 3 + 3 HF ⟶ ... Haire, Richard G. (2006). "Actinium". In Morss; Edelstein, Norman M.; Fuger, Jean (eds.). The Chemistry of the Actinide and ...
1776 Actinia zonata Rathke, 1836 Actinia cari Actinia equina Actinia fragacea Actinia mediterranea Actinia striata Actinia ... 1846 Actinia grobbeni Watzl, 1922 Actinia iris Müller, 1789 Actinia kraemeri Pax, 1914 Actinia laurentii Brandt, 1835 Actinia ... 1833 Actinia prasina Gosse, 1860 Actinia punctata Gay, 1854 Actinia pusilla Swartz, 1788 Actinia reclinata Bosc, 1802 Actinia ... 1833 Actinia striata Rizzi, 1907 Actinia strigata Quoy & Gaimard, 1833 Actinia tabella Drayton in Dana, 1846 Actinia taeniata ...
... but size also can help as Actinia mediterranea is a bit larger (5 to 7 cm) than its close relative (3 to 5 cm). Actinia ... "Actinia schmidti (Monteiro, Sole-Cava & Thorpe, 1997)". World Register of Marine Species. uBIO (2014). "Actinia schmidti ( ... Actinia mediterranea leads a benthic way of life and is an active carnivore, catching its prey at night by displaying its ... Actinia mediterranea is a common sea anemone found on rocky shores all along its range in the Mediterranean Sea, Portuguese ...
... is an unaccepted scientific name and may refer to two species of sea anemones: Bubble-tip anemone (Entacmaea ...
... is an unaccepted scientific name and may refer to: Aulactinia verrucosa, the gem anemone Cereus ...
... is a scientific synonym for two different species of sea anemone. It may refer to: Stichodactyla gigantea ... Stichodactyla haddoni This disambiguation page lists articles associated with the title Actinia gigantea. If an internal link ...
... is an unaccepted scientific name and may refer to two species of sea anemone: Sagartia elegans, found in coastal ...
... is a species of sea anemone endemic to the Mediterranean Sea. Actinia striata is a solitary sea anemone. The ... "Actinia striata". DORIS. Retrieved 4 April 2018. Photos of Actinia striata on Sealife Collection (Cite IUCN maint, Articles ... It can occur at greater depths than Actinia mediterranea or Actinia equina. Like other sea anemones, it is carnivorous, feeding ... Actinia striata is found in very shallow water in the Mediterranean Sea and nowhere else. The International Union for ...
... is an unaccepted scientific name and may refer to two species of sea anemone: Heteractis aurora, found from the ...
Media related to Passiflora actinia at Wikimedia Commons Data related to Passiflora actinia at Wikispecies v t e (Articles with ... Passiflora actinia is an evergreen vine. Native to Brazil, it is a relatively cold tolerant passion flower, and can be seen in ... Passiflora actinia, also known as the sea anemone passion flower is a species of passion flower (passionfruit) of the ... ISBN 0-88192-648-5. "Actinia". Merriam-Webster.com Dictionary, Merriam-Webster. Retrieved 3 July 2021. ...
Wikimedia Commons has media related to Actinia tenebrosa. Fautin, Daphne (2010). "Actinia tenebrosa Farquhar, 1898". World ... Actinia tenebrosa is similar in form to the beadlet anemone (Actinia equina) of the northern hemisphere. The column has a ... Actinia tenebrosa, commonly known as the waratah anemone, is the most common species of sea anemone found in the waters of ... Ayre, David J. (1985). "Localized Adaptation of Clones of the Sea Anemone Actinia tenebrosa". Evolution. 39 (6): 1250-1260. doi ...
"Celenterati - Actinia cari". Pagurus.it. Archived from the original on 2013-02-18. Retrieved 2012-10-31. " Actinia cari - Delle ... Actinia cari is a species of sea anemone in the family Actiniidae. It is native to the Mediterranean Sea where it is an ... Actinia cari lives in rocky areas, attaching itself to rocks and the underside of smooth stones. It is a common species and is ... Actinia cari grows to approximately 4-5 centimetres wide, and 8 centimetres high. It can fully retract its tentacles. It has a ...
... is an unaccepted scientific name and may refer to: Calliactis parasitica, a species of sea anemone Metridium ...
... , the red, maroon or stinging anemone, is a species of sea anemone in the family Actiniidae. Actinia ... Actinia bermudensis occurs in the West Indies, Bermuda and northern Florida, Greece, Caribian pool, west Atlantica and there is ... She opens up when it is storm and waits when strong waves bring her some fish and plancton Actinia bermudensis is an omnivore. ... Actinia bermudensis often contains these flagellate protozoa living within its tissues but they are of a non-photosynthetic ...
... is a sea sponge belonging to the family Tethyidae. While it is highly toxic to fish, it is known to be preyed ... "WoRMS - World Register of Marine Species - Tethya actinia de Laubenfels, 1950". www.marinespecies.org. Retrieved 14 November ...
... is a moth in the family Cosmopterigidae. It is found in Australia, where it has been recorded from New South ...
... is similar in form to the beadlet anemone (Actinia equina) and was at one time considered to be a variant of ... Actinia fragacea, commonly known as the strawberry anemone, is a species of sea anemone of the order Actiniaria, that occurs ... 113-. ISBN 978-94-011-5888-6. "Strawberry anemone - Actinia fragacea". MarLIN. Retrieved 2015-08-18. Swinney, Geoffrey N. ( ...
The isotopes of actinium range in atomic weight from 204 u (204 Ac) to 236 u (236 Ac). Actinium is found only in traces in ... Actinium gave the name to the actinide series, a set of 15 elements between actinium and lawrencium in the periodic table. ... The actinium isotope 227Ac is a transient member of the uranium-actinium series decay chain, which begins with the parent ... Actinium metal has been prepared by the reduction of actinium fluoride with lithium vapor in vacuum at a temperature between ...
This WebElements periodic table page contains biological information for the element actinium ... How much actinium is in your body? Find out here.. You can use this form to calculate how much actinium your body contains. ... Calculate how much actinium is in your body. Enter your weight here: kilograms. pounds. You contain about :. grams of actinium ... Actinium does not occur to any significant extent in the biosphere and so normally never presents a risk. Actinium is studied ...
This WebElements periodic table page contains crystal structures for the element actinium ... Actinium crystal structure image (space filling style).. Actinium crystal structure image displayed using JSMol. Try rotating ... Actinium - 89Ac Your user agent does not support the HTML5 Audio element. 🔊 ... Actinium crystal structure image (ball and stick style).. ... You may view the structure of actinium:. *interactively (best, ...
Retrieved from "https://citizendium.org/wiki/index.php?title=Actinium/Electronegativity&oldid=490562" ...
Retrieved from "https://citizendium.org/wiki/index.php?title=Actinium/Standard_phase&oldid=491309" ...
Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix.... ...
Explore working for Actinium Pharmaceuticals and see what its like to work in the area. ...
Detailed decay information for the isotope actinium-232 including decay chains and daughter products. ... Actinium Pictures Page. Al. Si. P. S. Cl. Ar. K. Ca. Actinium Technical Data. Sc. Ti. V. Cr. Mn. Fe. Co. Ni. Cu. Zn. Ga. Ge. As ... Isotopes of Actinium (click to see decay chain):. 206Ac 207Ac 208Ac 209Ac 210Ac 211Ac 212Ac 213Ac 214Ac 215Ac 216Ac 217Ac 218Ac ... Actinium Main Page. Black White Gray. B. C. N. O. F. Ne. ...
PRNewswire/ -- Actinium Pharmaceuticals, Inc. (NYSE American: ATNM) (Actinium or the Company) announced today the ... Actinium Appoints Lynn Bodarky as Chief Business Officer Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) (Actinium or the ... About Actinium Pharmaceuticals, Inc.. Actinium Pharmaceuticals Inc. is focused on improving patient access and outcomes to ... Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) (Actinium or the Company), a leader in the development of targeted ...
The Wooden Periodic Table Table by Theodore Gray
PRNewswire/ -- Actinium Pharmaceuticals, Inc. (NYSE American: ATNM), announced today that two oral and four poster ... Presenter: Dale Ludwig, PhD, Actinium Pharmaceuticals, Inc. Poster #54. Title: A Phase 2 Study of Actinium-225 (Ac-225- ... About Actinium Pharmaceuticals, Inc.. Actinium Pharmaceuticals Inc. is focused on improving patient access and outcomes to ... Dale Ludwig, Actiniums Chief Scientific Officer, said, "Actinium-225 is an isotope with great potential for therapeutic ...
... github.com/mundialis/actinia_core/releases/download/4.2.0/actinia_core-4.2.0-py2.py3-none-any.whl" pip3 install "actinia-api @ ... raw.githubusercontent.com/mundialis/actinia_core/main/requirements.txt python3 -m actinia_core.main A running redis instance is ... Update the actinia installer to use the above pip install (but needs to go into a separate virtualenv). Then add a section to ... Since the deadline for RC1 is this weekend, the PSC has decided to move actinia to VM only. There is no time to prepare debian ...
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... have optimised the production process for actinium-225 (Ac-225). Targeted therapy using... ... The new production process significantly increases the volume of actinium production. This is due to the upgrade of the Ac-225 ... have optimised the production process for actinium-225 (Ac-225). Targeted therapy using radiopharmaceuticals based on the ...
Actinium Pharmaceuticals Inc. tapped Mark Berger to replace Dragan Cicic as the companys chief medical officer. ... Berger joins Actinium from Kadmon Corp., where he was senior vice president of clinical research. ...
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Iodine i 131 apamistamabis under clinical development by Actinium Pharmaceuticals and currently in Phase II for Myelodysplastic ... Actinium Pharmaceuticals overview. Actinium Pharmaceuticals (Actinium) develops antibody radiation conjugates (ARC), which ... Iodine i 131 apamistamab by Actinium Pharmaceuticals for Myelodysplastic Syndrome: Likelihood of Approval. Brought to you by ... Iodine i 131 apamistamab is under clinical development by Actinium Pharmaceuticals and currently in Phase II for ...
Actinia bietet über ein Plugin die Möglichkeit, bestehende STAC Collections zu registrieren, so dass diese als Input für ... Dieser Vortrag zeigt am Beispiel von actinia und dem openeo-grassgis-driver, wie so eine Implementierung aussehen kann. ... Dieser Vortrag zeigt am Beispiel von [actinia](https://github.com/mundialis/actinia_core) und dem [openeo-grassgis-driver]( ... Vortragsfolien: https://mundialis.github.io/fossgis2022/stac-openeo-actinia/index.html Quellen: https://github.com/mundialis/ ...
Chem. 18, 42 (1961). Discovery of 228Ac: O. Hahn, Ber. 40, 1462 (1907). Review of actinium and the actinides: Comprehensive ...
NYSE: BWXT), today announced that the companies have entered into a preferred partner agreement for the supply of actinium-225. ... Actinium-225 is an alpha-emitting isotope used in targeted alpha therapies (TATs) that combine the isotope with specific tumor- ... BWXT Medical is now producing high-purity non-carrier added actinium-225. Fusion is a leading developer of targeted alpha ... NYSE: BWXT), today announced that the companies have entered into a preferred partner agreement for the supply of actinium-225 ...
... javne objave ACTINIA MEDICO trgovina z medicinskimi potrebščinami d.o.o. iz aplikacije SEOnet. ...
Learn more about Radiopharm and TerraPowers supply agreement for Actinium-225 here. ... Radiopharm and TerraPower sign supply agreement for Actinium-225. By TerraPower MediaFebruary 1, 2022No Comments ... Actinium-225 is an alpha-emitting radionuclide with significant promise in effectively treating cancer patients. It can be ... The Actinium-225 will be utilized in drug trials involving targeted alpha therapy in multiple disease areas. ...
Actinium Pharmaceuticals Stock forecast & analyst price target predictions based on 3 analysts offering 12-months price targets ... Actinium Pharmaceuticals downgraded to Market Perform from Outperform at William BlairActinium Pharmaceuticals downgraded to ... Actinium Pharmaceuticals has a conensus rating of Strong Buy which is based on 3 buy ratings, 0 hold ratings and 0 sell ratings ... Actinium Pharmaceuticalss analyst rating consensus is a Strong Buy. This is based on the ratings of 3 Wall Streets Analysts. ...
Obtida de "https://pt.wiktionary.org/w/index.php?title=Actinium&oldid=2263334" ...
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Home / Stock Badges / 75mm Button Badges / 75mm Chemical Element Badges / 75mm Actinium Button Badge. 75mm Actinium Button ... 75mm Actinium Button Badge. Customisation Options. If you would like us to customise this badge for you, by adding text curved ...
  • Dieser Vortrag zeigt am Beispiel von [actinia](https://github.com/mundialis/actinia_core) und dem [openeo-grassgis-driver](https://github.com/Open-EO/openeo-grassgis-driver), wie so eine Implementierung aussehen kann. (ccc.de)
  • About Actinium Pharmaceuticals. (niche.com)
  • NEW YORK , Jan. 23, 2019 /PRNewswire/ -- Actinium Pharmaceuticals, Inc. (NYSE American: ATNM) ("Actinium" or "the Company") announced today the appointment of Cynthia Pussinen as Executive Vice President, Technical Operations and Supply Chain. (prnewswire.com)
  • Actinium Pharmaceuticals Inc. tapped Mark Berger to replace Dragan Cicic as the company's chief medical officer. (spglobal.com)
  • Iodine i 131 apamistamab is under clinical development by Actinium Pharmaceuticals and currently in Phase II for Myelodysplastic Syndrome. (pharmaceutical-technology.com)
  • Actinium Pharmaceuticals (Actinium) develops antibody radiation conjugates (ARC), which combine the targeting ability of antibodies with the cell killing ability of radiation. (pharmaceutical-technology.com)
  • Ottawa, ON) - January 5, 2023 - Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), and BWXT Medical Ltd., a subsidiary of BWX Technologies, Inc. (NYSE: BWXT), today announced that the companies have entered into a preferred partner agreement for the supply of actinium-225. (bwxt.com)
  • Actinium Pharmaceuticals' drug development pipeline features Iomab-B, which completed enrollment of its pivotal Phase 3 clinical trial, Iomab-ACT, which is intended to be a conditioning regimen for cell and gene therapies that is being studied in an NIH funded clinical study and Actimab-A, which is being studied in two combination trials for relapsed/refractory AML. (actiniumpharma.com)
  • For more information, please visit Astellas' website at https://www.astellas.com/en . (actiniumpharma.com)
  • tool ( details ) allows the execution of a single GRASS GIS command or a list of GRASS GIS commands on an actinia REST service ( https://actinia.mundialis.de/ ). (osgeo.org)
  • Then add a section to the quickstart to use the local actinia deployment instead of the remote one. (osgeo.org)
  • Do not change the installer this year but add a section to the quickstart with docker instructions (docker is now available on the VM version) so that users can run actinia through docker as an exercise. (osgeo.org)
  • In this quickstart, we make use of GRASS GIS to conveniently launch commands from the session to the actinia server (which itself uses GRASS GIS). (osgeo.org)
  • Actinium gave the name to the actinide series, a set of 15 elements between actinium and lawrencium in the periodic table. (wikipedia.org)
  • Actinium (Ac) is a silvery colored radioactive metal that has the atomic number 89 in the periodic table. (breakingatom.com)
  • Actinium is one of the most elusive elements in the periodic table, having a number of unforeseen properties that make it an ideal candidate for scientific study. (tqhp.com)
  • The term refers to the heaviest elements, starting with actinium and continuing to the end of the periodic table. (cdc.gov)
  • As with most lanthanides and many actinides, actinium assumes oxidation state +3 in nearly all its chemical compounds. (wikipedia.org)
  • The first element of the actinides, actinium gave the set its name, much as lanthanum had done for the lanthanides. (wikipedia.org)
  • Actinides - radioactive elements with atomic numbers equal to or greater than that of actinium (i.e., 88). (cdc.gov)
  • Our collaboration with Radiopharm Theranostics aligns with our vision to provide broad industry access to Actinium-225, enabling partners to develop much-needed radiopharmaceuticals. (terrapower.com)
  • A new batch of accelerator-produced actinium-225 (Ac-225) will be available through the U.S. Department of Energy Isotope Program (DOE IP) in mid to late June 2019. (isotopes.gov)
  • Actinium is found only in traces in uranium and thorium ores as the isotope 227Ac, which decays with a half-life of 21.772 years, predominantly emitting beta and sometimes alpha particles, and 228Ac, which is beta active with a half-life of 6.15 hours. (wikipedia.org)
  • Dr. Dale Ludwig , Actinium's Chief Scientific Officer, said, "Actinium-225 is an isotope with great potential for therapeutic applications given its high energy, short pathlength and 10-day half-life. (prnewswire.com)
  • Actinium-225 is an alpha-emitting isotope used in targeted alpha therapies (TATs) that combine the isotope with specific tumor-seeking targeting vectors to kill cancer cells while minimizing the impact to healthy tissues. (bwxt.com)
  • There is growing demand for the isotope but a limited number of suppliers who are currently able to produce meaningful quantities of high purity actinium. (bwxt.com)
  • As an established global leader in medical isotope manufacturing and supply with proven ability to produce high purity actinium, BWXT Medical has the necessary infrastructure and shipping logistics capabilities to support both clinical and commercial scale manufacturing and distribution of medical isotopes. (bwxt.com)
  • The close similarity of physical and chemical properties of actinium and lanthanum makes separation of actinium from the ore impractical. (wikipedia.org)
  • Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix. (ornl.gov)
  • What is the Electronegativity of Actinium? (breakingatom.com)
  • The atoms of actinium are characterized by a high electron affinity (kJ/mol) and a relatively low electronegativity (1.1). (tqhp.com)
  • A soft, silvery-white radioactive metal, actinium reacts rapidly with oxygen and moisture in air forming a white coating of actinium oxide that prevents further oxidation. (wikipedia.org)
  • Actinium is a soft radioactive metal that reacts with oxygen to form a layer of actinium oxide. (breakingatom.com)
  • One tonne of natural uranium in ore contains about 0.2 milligrams of actinium-227, and one tonne of thorium contains about 5 nanograms of actinium-228. (wikipedia.org)
  • Actinium has similar chemical properties to lanthanum and other lanthanides, and therefore these elements are difficult to separate when extracting from uranium ores. (wikipedia.org)
  • Since 2018, TerraPower has been working to increase the supply of Actinium-225 from Thorium-229 decay, which is derived from Uranium-233 managed by the U.S. Department of Energy. (terrapower.com)
  • Electrons are produced during the decay of other atoms, such as when a uranium atom decays into actinium. (tqhp.com)
  • How Many Electrons Does Actinium Have? (tqhp.com)
  • The actinide series contains 15 metallic elements from number 89 (actinium) to 103 (lawrencium). (breakingatom.com)
  • Actinia develops radiation detection solutions for medical imaging, nuclear energy applications, and non-proliferation of illicit radioactive materials. (kairosventures.com)
  • Actinium is a chemical element with the symbol Ac and atomic number 89. (wikipedia.org)
  • Its symbol Ac is also used in abbreviations of other compounds that have nothing to do with actinium, such as acetyl, acetate and sometimes acetaldehyde. (wikipedia.org)
  • Actinium is advancing the only multi-disease, multi-target, clinical-stage pipeline for targeted conditioning to enable cellular therapies such as BMT or Bone Marrow Transplant (BMT) and CAR-T. The target market for Actinium's ARC or Antibody Radiation Conjugate drug candidates is concentrated within the top 75-100 hospitals in the U.S. that perform a majority of BMT and CAR-T procedures. (prnewswire.com)
  • Sandesh Seth , Actinium's Chairman and CEO said, "We are pleased to expand our core leadership team with a seasoned executive of Cynthia's caliber who has a proven ability to execute and drive growth in areas that are highly relevant to Actinium. (prnewswire.com)
  • In addition to highlighting Actinium's clinical programs and AWE platform, Actinium will present a poster comparing the feasibility of using Ac-225 produced in a high-energy linear proton accelerator by the DOE or U.S. Department of Energy to that of traditional Ac-225 produced in a "thorium cow" or generator. (prnewswire.com)
  • Cynthia joins Actinium from Pfizer, where she was the Head of Strategic Portfolio Management, Worldwide Research & Development. (prnewswire.com)
  • Berger joins Actinium from Kadmon Corp., where he was senior vice president of clinical research. (spglobal.com)
  • Russia's AI Leipunsky Institute of Physics & Power Engineering (IPPE) together with V/O Izotop JSC (part of Rusatom Healthcare), have optimised the production process for actinium-225 (Ac-225). (neimagazine.com)
  • Access to high quality Actinium-225 allows us to accelerate the clinical development of our broad pipeline," said Riccardo Canevari, CEO and managing director of Radiopharm. (terrapower.com)
  • the element got its name by being wrongly identified with a substance André-Louis Debierne found in 1899 and called actinium. (wikipedia.org)
  • Actinium was first isolated in 1899 by French chemist André-Louis Debierne, a French scientist. (breakingatom.com)
  • In April 2022, Actinium announced Immedica licensed the rights to commercialize Iomab-B (1-131 apamistamab) in the EU, Middle East and North Africa. (actiniumpharma.com)
  • Actinia is an open source REST API for scalable, distributed, high performance processing of geographical data that uses GRASS GIS for computational tasks. (osgeo.org)
  • Giesel, on the other hand, can rightfully be credited with the first preparation of radiochemically pure actinium and with the identification of its atomic number 89. (wikipedia.org)
  • Actinium is studied in a few nuclear research laboratories where its high radioactivity requires special handling techniques and precautions. (webelements.com)
  • The new production process significantly increases the volume of actinium production. (neimagazine.com)
  • This agreement increases our existing actinium supply for both current programs as well as future business development opportunities and partnered programs, diversifies our supply chain, and establishes a relationship to collaborate on longer-term commercial production needs. (bwxt.com)
  • Due to its highly differentiated properties, we are increasing our research related to targeted Actinium-225 through our AWE platform to continue to drive highly differentiated programs to further expand our pipeline into areas of unmet need. (prnewswire.com)
  • Actinium is focused on continuing to expand its drug development pipeline of targeted radiotherapies for patients with blood cancers and solid tumors. (actiniumpharma.com)
  • Actinium has forged strong partnerships with companies globally who share our vision of bringing targeted radiotherapies to patients in need. (actiniumpharma.com)
  • Latest version of actinia is now missing from Pypi. (osgeo.org)
  • Owing to its scarcity, high price and radioactivity, actinium has no significant industrial use. (wikipedia.org)
  • BWXT Medical is now producing high-purity non-carrier added actinium-225. (bwxt.com)
  • The Actinium-225 will be utilized in drug trials involving targeted alpha therapy in multiple disease areas. (terrapower.com)
  • D., said, "Excitement for the potential of targeted alpha therapies to treat cancer is growing, and we have made the necessary investments in infrastructure and intellectual property to help meet the increasing global demand for actinium. (bwxt.com)
  • Based on emerging clinical data in the literature which show the power of alpha particles over conventional beta emitters, we continue to proactively prioritize access to actinium as a critical component of Fusion's development plans and we are excited to partner with BWXT Medical. (bwxt.com)
  • Together with polonium, radium, and radon, actinium was one of the first non-primordial radioactive elements to be isolated. (wikipedia.org)
  • Ms. Pussinen brings 25 years of highly relevant technical operations and supply chain experience from executive roles at global biopharmaceutical organizations Pfizer and Ipsen to Actinium. (prnewswire.com)
  • Actinia provides a REST API to process satellite images, time series of satellite images, raster and vector data. (osgeo.org)
  • ACTINIUM will provide you with a certified and genuine buying/selling platform. (actinium.in)
  • Ephemeral processing is the default processing approach of actinia. (osgeo.org)