Actinium. A trivalent radioactive element and the prototypical member of the actinide family. It has the atomic symbol Ac, atomic number 89, and atomic weight 227.0278. Its principal isotope is 227 and decays primarily by beta-emission.
Thorium. A radioactive element of the actinide series of metals. It has an atomic symbol Th, atomic number 90, and atomic weight 232.04. It is used as fuel in nuclear reactors to produce fissionable uranium isotopes. Because of its radioopacity, various thorium compounds are used to facilitate visualization in roentgenography.

Preparation of alpha-emitting 213Bi-labeled antibody constructs for clinical use. (1/23)

Preclinical evaluation of alpha particle-emitting 213Bi-labeled antibody constructs have demonstrated the specificity and potency of these agents in a variety of cancer systems. The transition of a 213Bi-radiolabeled antibody from a preclinical construct to a clinical drug represented a difficult task that involved development of reliable and validated methods to provide multiple MBq quantities of a pure, immunoreactive agent that met pharmaceutical standards to treat patients. METHODS: The methods used for the preparation of (213Bi)CHX-A-diethylenetriamine pentaacetic acid (DTPA)-HuM195, an alpha particle-emitting anti-CD33 antibody construct for therapy of myeloid leukemias, is used as a specific example. This article describes methods for reagent purification, drug labeling, radioprotection and chromatographic purification. Quality of the drug is evaluated using radiochemical incorporation and purity assays with instant thin-layer chromatography (ITLC) and high-performance liquid chromatography (HPLC), determination of cell-based antibody total immunereactivity, small animal safety, pyrogen level, sterility and radionuclidic purity. RESULTS: Sixty-seven doses were prepared. Individual doses ranged from 148 to 814 MBq. Specific activities ranged from 329 to 766 MBq/mg. The radiolabeling efficiency (median +/- SD) of CHX-A-DTPA-HuM195 with 213Bi was 81% +/- 9% (n = 67) after 9 min. The construct was purified by size-exclusion chromatography and was found to be 99% +/- 2% pure (n = 67) by either ITLC or HPLC methods. The immunoreactivity of (213Bi)CHX-A-DTPA-HuM195 was 89% +/- 9% (n = 44) and was independent of the specific activity. The formulated pharmaceutical was found to contain < or =4 +/- 1 EU/mL pyrogens (n = 66); all samples examined were sterile. An 225Ac radionuclidic impurity was present at a level of 0.04 +/- 0.03 x 10(-6)/mL (n = 10) in a product volume of 7.4 +/- 0.5 mL (n = 67). Each of the 67 doses was injected intravenously into patients without complication as part of a phase I clinical trial. CONCLUSION: These data show that 213Bi-labeled antibody constructs can be prepared and administered safely to humans at a wide range of therapeutic levels.  (+info)

Tumor therapy with targeted atomic nanogenerators. (2/23)

A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to target molecular-sized generators of alpha-emitting isotope cascades to the inside of cancer cells using actinium-225 coupled to internalizing monoclonal antibodies. In vitro, these constructs specifically killed leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate cancer cells at becquerel (picocurie) levels. Injection of single doses of the constructs at kilobecquerel (nanocurie) levels into mice bearing solid prostate carcinoma or disseminated human lymphoma induced tumor regression and prolonged survival, without toxicity, in a substantial fraction of animals. Nanogenerators targeting a wide variety of cancers may be possible.  (+info)

Targeted actinium-225 in vivo generators for therapy of ovarian cancer. (3/23)

Advanced ovarian cancer is largely incurable, but initially it is frequently confined to the i.p. space. We explored i.p. radioimmunotherapy in a mouse model of human ovarian cancer. Use of a targeted actinium-225 ((225)Ac) in vivo generator of alpha particles exploits the extreme, selective cytotoxicity of alpha particles, while providing a feasible half-life to enable delivery to tumor. (225)Ac chelated with 2-(p-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10 tetraacetic acid was conjugated to trastuzumab, an anti-HER-2/neu antibody. The radioimmunoconjugate was tested for immunoreactivity, internalization, and cytotoxicity using a human ovarian carcinoma cell line, SKOV3. (225)Ac-labeled trastuzumab retained immunoreactivity (50-90%), rapidly internalized into cells (50% at 2 h), and had an ED(50) of 1.3 nCi/ml after 4 days of incubation in vitro. i.p. administered (225)Ac- or (111)In-labeled trastuzumab behaved similarly with high tumor uptake [56-60% injected dose per gram (% ID/g) at 4 h, which increased to 65-70% ID/g at 24 h]. Tumor uptake was 3-5-fold higher than liver and spleen, the normal organs with the highest uptake. i.v. administration of (111)In-labeled trastuzumab produced slightly higher normal organ uptake compared with i.p.-administered (111)In-labeled trastuzumab. However, tumor uptake was low, 5%-26% ID/g. Therapy was examined with native trastuzumab and 220, 330, and 450 nCi of (225)Ac-labeled trastuzumab or (225)Ac-labeled control antibody at different dosing schedules. Therapy was initiated 9 days after tumor seeding. Groups of control mice and those administered native trastuzumab had median survivals of 33 and 37 or 44 days, respectively. Median survival was 52-126 days with (225)Ac-labeled trastuzumab at various doses and schedules, and 48-64 days for (225)Ac-labeled control the same schedules. Deaths from toxicity occurred with the highest activity levels. In conclusion, i.p. administration with a (225)Ac-labeled internalizing anti-HER-2/neu antibody can extend survival significantly in a nude mouse model of human ovarian cancer at levels that produce no apparent gross toxicity.  (+info)

Pharmacokinetics, dosimetry, and toxicity of the targetable atomic generator, 225Ac-HuM195, in nonhuman primates. (4/23)

Short-lived alpha-emitting isotopes individually conjugated to monoclonal antibodies have now reached human use, but little is still known about their toxicity. Use of antibody targetable (225)Ac nanogenerators is a new approach in the field of alpha-immunotherapy offering the advantage of a 10-d half-life (t(1/2)) and increased potency due to generation of 3 new atoms, yielding a total of 4 alpha-particles. However, the 3 alpha-emitting daughter elements generated have the potential for significant toxicity as these nuclides are no longer bound to the carrier IgG. METHODS: Cynomolgus monkeys were used to evaluate the toxicity of prototype (225)Ac nanogenerators. Monoclonal antibody HuM195 (anti-CD33) is the carrier for planned human clinical trials of (225)Ac; there are no CD33 sites in cynomolgus monkeys. In one experiment, 2 monkeys received a single intravenous dose of (225)Ac-HuM195 at 28 kBq/kg. This dose level is approximately the planned initial human dose. In another experiment, 2 animals received a dose escalation schedule of 3 increasing (225)Ac-HuM195 doses with a cumulative activity of 377 kBq/kg. The whole-blood t(1/2) of (225)Ac, ratios of (225)Ac to its ultimate alpha-emitting daughter nuclide (213)Bi, generation of monkey anti-HuM195 antibodies (MAHA), hematologic indices, serum biochemistries, and clinical parameters were measured. Monkeys were euthanized and examined histopathologically when the dose escalation reached toxicity. RESULTS: The blood t(1/2) of (225)Ac-HuM195 was 12 d, and 45% of generated (213)Bi daughters were cleared from the blood. MAHA production was not detected. Approximately 28 kBq/kg of (225)Ac caused no toxicity at 6 mo, whereas a cumulative dose of approximately 377 kBq/kg caused severe toxicity. In the cumulative dosing schedule, single doses of approximately 37 kBq/kg resulted in no toxicity at 6 wk. After approximately 130 kBq/kg were administered, no toxicity was observed for 13 wk. However, 28 wk after this second dose administration, mild anemia and increases of blood urea nitrogen and creatinine were detected. After administration of an additional 185 kBq/kg, toxicity became clinically apparent. Monkeys were euthanized 13 and 19 wk after the third dose administration (cumulative dose was 377 kBq/kg). Histopathologic evaluation revealed mainly renal tubular damage associated with interstitial fibrosis. CONCLUSION: (225)Ac nanogenerators may result in renal toxicity and anemia at high doses. The longer blood t(1/2) and the lack of target cell antigens in cynomolgus monkeys may increase toxicity compared with human application. Therefore, a dose level of at least 28 kBq/kg may be a safe starting dose in humans. Hematologic and renal function will require close surveillance during clinical trials.  (+info)

Engineered liposomes for potential alpha-particle therapy of metastatic cancer. (5/23)

Disseminated, metastatic cancer is frequently incurable. Targeted alpha-particle emitters hold great promise as therapeutic agents for disseminated disease. (225)Ac is a radionuclide generator that has a 10-d half-life and results in alpha-emitting daughter elements ((221)Fr, (217)At, (213)Bi) that lead to the emission of a total of 4 alpha-particles. The aim of this study was to develop approaches for stable and controlled targeting of (225)Ac to sites of disseminated tumor metastases. Liposomes with encapsulated (225)Ac were developed to retain the potentially toxic daughters at the tumor site. METHODS: (225)Ac was passively entrapped in liposomes. To experimentally test the retention of actinium and its daughters by the liposomes, the gamma-emissions of (213)Bi were measured in liposome fractions, which were separated from the parent liposome population and the free radionuclides, at different times. Under equilibrium conditions the decay rate of (213)Bi was used to determine the concentration of (225)Ac. Measurements of the kinetics of (213)Bi activity were performed to estimate the entrapment of (213)Bi, the last alpha-emitting daughter in the decay chain. RESULTS: Stable pegylated phosphatidylcholine-cholesterol liposomes of different sizes and charge were prepared. Multiple (more than 2) (225)Ac atoms were successfully entrapped per liposome. (225)Ac retention by zwitterionic liposomes was more than 88% over 30 d. Retention by cationic liposomes was lower. A theoretical calculation showed that for satisfactory (213)Bi retention (>50%), liposomes of relatively large sizes (>650 nm in diameter) are required. (213)Bi retention was experimentally verified to be liposome-size dependent. For large liposomes, the measured (213)Bi retention was lower than theoretically predicted (less than 10%). CONCLUSION: This work supports the hypothesis that it may be possible to develop (225)Ac-based therapies by delivering multiple (225)Ac atoms in liposomes. Improvements in the retention of (225)Ac daughters will likely be necessary to fulfill this potential. Because of the size of the liposomal structures required to contain the daughters, the approach is ideally suited for locoregional therapy (e.g., intraperitoneal, intrahepatic artery, or intrathecal).  (+info)

Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents. (6/23)

The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.  (+info)

Alpha-particle emitting atomic generator (Actinium-225)-labeled trastuzumab (herceptin) targeting of breast cancer spheroids: efficacy versus HER2/neu expression. (7/23)

PURPOSE: The humanized monoclonal antibody, trastuzumab (Herceptin), directed against HER2/neu, has been effective in the treatment of breast cancer malignancies. However, clinical activity has depended on HER2/neu expression. Radiolabeled trastuzumab has been considered previously as a potential agent for radioimmunotherapy. The objective of this study was to investigate the efficacy of trastuzumab labeled with the alpha-particle emitting atomic generator, actinium-225 ((225)Ac), against breast cancer spheroids with different HER2/neu expression levels. (225)Ac has a 10-day half-life and a decay scheme yielding four alpha-particles. EXPERIMENTAL DESIGN: The breast carcinoma cell lines MCF7, MDA-MB-361 (MDA), and BT-474 (BT) with relative HER2/neu expression (by flow cytometry) of 1:4:18 were used. Spheroids of these cell lines were incubated with different concentrations of (225)Ac-trastuzumab, and spheroid growth was measured by light microscopy over a 50-day period. RESULTS: The activity concentration required to yield a 50% reduction in spheroid volume at day 35 was 18.1, 1.9, and 0.6 kBq/ml (490, 52, 14 nCi/ml) for MCF7, MDA, and BT spheroids, respectively. MCF7 spheroids continued growing but with a 20-30 day growth delay at 18.5 kBq/ml. MDA spheroid growth was delayed by 30-40 days at 3.7 kBq/ml; at 18.5 kBq/ml, 12 of 12 spheroids disaggregated after 70, days and cells remaining from each spheroid failed to form colonies within 2 weeks of being transferred to adherent dishes. Eight of 10 BT spheroids failed to regrow at 1.85 kBq/ml. All of the BT spheroids at activity concentrations 3.7 kBq/ml failed to regrow and to form colonies. The radiosensitivity of these three lines as spheroids was evaluated as the activity concentration required to reduce the treated to untreated spheroid volume ratio to 0.37, denoted DVR(37). An external beam radiosensitivity of 2 Gy was found for spheroids of all three of the cell lines. After alpha-particle irradiation a DVR(37) of 1.5, 3.0, and 2.0 kBq/ml was determined for MCF7, MDA, and BT, respectively. CONCLUSION: These studies suggest that (225)Ac-labeled trastuzumab may be a potent therapeutic agent against metastatic breast cancer cells exhibiting intermediate to high HER2/neu expression.  (+info)

Treatment of neuroblastoma meningeal carcinomatosis with intrathecal application of alpha-emitting atomic nanogenerators targeting disialo-ganglioside GD2. (8/23)

Labeling of specific antibodies with bifunctional chelated Actinium-225 ((225)Ac; an alpha generator) allows the formation of new, highly potent and selective alpha-emitting anticancer drugs. We synthesized and evaluated a radioimmunoconjugate based on 3F8, an IgG(3) antibody that specifically binds to ganglioside GD2, which is overexpressed by many neuroectodermal tumors including neuroblastoma. The (225)Ac-1,4,7,10-tetra-azacylododecane (DOTA)-3F8 construct was evaluated for radiochemical purity and sterility, immunoreactivity, cytotoxicity in vitro, induction of apoptosis on GD2-positive cells, as well as for pharmacological biodistribution and metabolism of the (225)Ac generator and its daughters in a nude mouse xenograft model of neuroblastoma. The (225)Ac-3F8 showed an IC(50) of 3 Bq/ml (80 pCi/ml) on the neuroblastoma cell line, NMB7, in vitro. Apoptosis of these cells was not observed. Biodistribution in mice showed specific targeting of a subcutaneous tumor; there was redistribution of the (225)Ac daughter nuclides mainly from blood to kidneys and to small intestine. Toxicity was examined in cynomolgus monkeys. Monkeys injected with 1 to 3 doses of intrathecal (225)Ac-3F8 radioimmunoconjugate (80 to 150 kBq/kg total dose) did not show signs of toxicity based on blood chemistry, complete blood counts, or by clinical evaluations. Therapeutic efficacy of intrathecal (225)Ac-3F8 was studied in a nude rat xenograft model of meningeal carcinomatosis. The (225)Ac-3F8 treatment improved survival 2-fold from 16 to 34 days (P = 0.01). In conclusion, in vivo alpha generators targeted by 3F8 warrant additional study as a possible new approach to the treatment of carcinomatous meningitis.  (+info)

NIH grant to support first of its kind clinical trial to use Antibody Radio-Conjugate for targeted conditioning prior to CAR T-cell therapy in patients with acute lymphoblastic leukemia and diffuse large B-cell lymphoma. ARC-based targeted lymphodepletion is intended to improve CAR T-cell patient outcomes by selectively depleting immune cells, including those implicated in CAR T-cell toxicities. Actinium to host Iomab-ACT program update call on October 22, 2020 at 8:00 AM EST. NEW YORK, NY - October 21, 2020 - Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) (Actinium or the Company) today announced that the National Institutes of Health has awarded Actinium a Small Business Technology Transfer grant to support a clinical collaboration with Memorial Sloan Kettering Cancer Center (MSK) to study Iomab-ACT, Actiniums CD45-targeting Antibody Radio-Conjugate, for targeted conditioning to achieve lymphodepletion prior to administration of a CD19-targeted CAR T-cell therapy developed at MSK. ...
NEW YORK, NY--(Marketwired - October 13, 2015) - Actinium Pharmaceuticals, Inc. (NYSE MKT: ATNM) (Actinium or the Company) is a biopharmaceutical Company developing innovative targeted payload immunotherapeutics for the treatment of advanced cancers. Actinium announced today the appointment of Steve OLoughlin to the position of Senior Director of Finance and...
Actinium Pharmaceuticals Inc. - Insider Activity and Holdings. Moreover, the latest SEC filings also revealed that stock came across 0 new insider purchases involving 0 shares. On the other hand, ATNM declared 0 shares have been sold in 0 insider transactions over the past three months.. As on Sep 29, 2020, Consonance Capital Management LP was the top most holder in Actinium Pharmaceuticals Inc. (AMEX:ATNM) with an ownership of 0.79 million shares of the company or 5.84% of the stake worth $7.69 million. The filing also reveals Vanguard Group, Inc. (The) as the second largest holder in the company with a control over 3.71% of the outstanding shares. Its stake is worth $4.89 million for having 0.5 million shares in hand.. Blackrock Inc. also came holding a key position in the company during the recent quarter and it now holds 1.47% of the outstanding shares. With this there are now 42 institutions which have possession in ATNMs shares.. Currently, the stock has been recommended as Strong Buy by ...
From BioPortfolio: NEW YORK, Oct. 19, 2016 (GLOBE NEWSWIRE) -- Actinium Pharmaceuticals, Inc. (NYSE MKT:ATNM) ("Actinium" or "the Company"), a biopharmaceutica...
The purpose of this study is to find a safe dose of actinium-225 when it is labeled to HuM195. This will be done with a phase I trial, in which a preset schedule of doses gets more powerful for each new group of patients as the trial progresses. If too many serious side effects are seen with a certain dose, no one will be treated with a higher dose, and some additional patients may be treated with a lower dose to make sure that this dose is safe. The starting dose of actinium-225 in this study is less than doses that are known to be safe in animals.. Antibodies are proteins that are produced by the immune system and help the body to fight foreign substances, such as bacteria or viruses. HuM195 was made by putting human leukemia cells into mice. Most of the mouse parts of this antibody were replaced with human parts. Only the part of the antibody that binds to the leukemia cells was kept from the mouse. HuM195 attaches to leukemia cells but does not attach to most normal cells. It can kill ...
Wearable medical devices such as continuous heart rate monitors, insulin pumps, and neural stimulators usually need access to an electric power source in order to function. While theres a great deal of wasted energy that our body emits that can be harvested to power such devices, making it actually happen using biocompatible materials has proven to be challenging. Now, a team of engineers at Purdue University has shown that polyvinyl alcohol (PVA), one of the most common polymers used in biomedicine, can be used to produce efficient triboelectric nanogenerators (TENGs) that can also act as cardiac activity monitors.. The PVA-based TENGs show great potential for self-powered biomedical devices and open doors to new technologies that use widely deployed biocompatible materials for economically feasible and ecologically friendly production of functional devices in energy, electronics and sensor applications, said Wenzhuo Wu, the leader of the research team. We transform PVA, one of the most ...
Combining traditional textiles with triboelectric nanogenerators (TENGs) gives birth to self-powered electronic textiles (e-textiles). However, there are two bottlenecks in their widespread application, low power output and poor sensing capability. Herein, by means of the three-dimensional five-directional braided (3DB) structure, a TENG-based e-textile with the features of high flexibility, shape adaptability, structural integrity, cyclic washability, and superior mechanical stability, is designed for power and sensing. Due to the spatial frame-column structure formed between the outer braided yarn and inner axial yarn, the 3DB-TENG is also endowed with high compression resilience, enhanced power output, improved pressure sensitivity, and vibrational energy harvesting ability, which can power miniature wearable electronics and respond to tiny weight variations. Furthermore, an intelligent shoe and an identity recognition carpet are demonstrated to verify its performance. This study hopes to provide a
Triboelectric nanogenerators (TENG) convert mechanical energy harvested from the environment to electricity for powering small devices such as sensors or for recharging consumer electronics. Now, researchers have harnessed ...
For the first time, fully bio-derived thermosets have been synthesized from abundantly available, low cost, renewable feedstocks through a simple, solvent-free and catalytic process for the fabrication of triboelectric nanogenerators (TENGs) for sustainable power generation. Thermoset films synthesized from
X-ray Research on Short-lived Isotope Provides New Possibilities for Cancer Treatment - Scientists Improve Understanding of Mysterious Actinium. Excerpted from August 22, 2016 SLAC News Feature. A recent paper published in Nature Communications reveals insights about the element actinium that could support new classes of anticancer drugs. A team of researchers from the Los Alamos National Laboratory has conducted x-ray absorption fine structure experiments on SSRLs Beam Line 11-2 to characterize the molecular and electronic structure, including chemical bonds in actinium compounds.. Using synchrotron-based tools to obtain a better understanding of the structure of Actinium-225, for example, looks promising. It has a relatively short half-life (10 days) and emits powerful alpha particles as it decays to stable bismuth. This makes it a perfect candidate for a novel cancer treatment technique called targeted-alpha therapy, where alpha emissions from radioisotopes destroy malignant cells while ...
A chemical element, Ac, atomic number 89, and atomic weight 227.0. Actinium was discovered by A. Debierne in 1899. Milligram quantities ...
NEW YORK, NY--(Marketwired - March 11, 2016) - Actinium Pharmaceuticals, Inc. (NYSE MKT: ATNM) (Actinium or the Company), a biopharmaceutical company developing innovative targeted payload immunotherapeutics for the treatment of advanced cancers, announced today that it has engaged a leading European-based regulatory affairs consulting firm to pursue orphan medicines designation...
If you are interested to know one of the rare earth elements, you have to check out Facts about Actinium. If you check out the periodic table, it is included in
Blue line and other details for Actinium Delight Minor. Classification: Delight Minor, Place Notation: x56x1456x1256x16.34x34.56,12
ATNM - key executives, insider trading, ownership, revenue and average growth rates. Detailed company description & address for Actinium Pharmaceuticals Inc..
Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.
used to conduct experiments to demonstrate the properties of radioactive decay. Based on the original Union Carbide patented design, it offers exceptional performance combined with ease of use and safe operation.
It is necessary to construct an amphiphobic triboelectric nanogenerator (TENG) since water, oil and other antistatic agents will have a great impact on its electrical output performance during practical applications. Herein, we put forward a high-performance TENG based on silica enhanced thermoplastic polymeric nan
Since cellulose is non-toxic, the researchers said the device could potentially be implanted in the body and harvest its internal stretches, vibrations and other movements.
Das Periodensystem der Elemente kurz, prägnat, übersichtlich. Die wichtigsten Infos schnell parat. Mit interaktiver Nuklidkarte inklusive.
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۲٫۰ ۲٫۱ ۲٫۲ Kirby, Harold W.; Morss, Lester R. (2006). [اصطلاحي تېروتنه: د ناپېژندلې ليکنښې لوښه ۱. Actinium]. The Chemistry of the Actinide and Transactinide Elements. pp. 18. doi:10.1007/1-4020-3598-5_2. ISBN 978-1-4020-3555-5. ...
- Dr. Gail Roboz, Director of the Leukemia Program and Professor of Medicine at Weill Cornell Medical College and NewYork-Presbyterian will introduce the pl...
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POCs Skull X race helmet features penetration proof ventilation and a multi-impact EPP liner to withstand multiple impacts and has a tapered shell for resistance and protection. The ear chambers are designed for less effect on balance and hearing. The Skull X also makes an excellent race helmet for junior ski racers.
Further analyses of data subsets from the ALSYMPCA study of the alpha particle-emitting isotope Ra-223 (Xofigo) were presented at ASCO, providing additional evidence of efficacy and safety of the recently FDA approved therapeutic agent.
CSIC through the Instituto de Microelectrónica de Barcelona - Centro Nacional de Microelectrónica, has developed a device based on nanogenerators for electrical cells stimulation without the need of electrodes or bulky devices. The device is biocompatible and, among its multiple applications, is able to actuate in medical prostheses as an enhancer of cellular growth and proliferation, which permits an early lesion recovery (such as a fracture or wound). Industrial partners dedicated to the development of medical devices for cells stimulation, in particular, focused onto therapeutic treatments of non-healing wounds, are being sought to collaborate through a patent license agreement.
Researchers at Georgia Tech have been working on the prototypes for six years and say that if placed in the perfect arrangement within layers of polymer material, they could be flexed to generate and capture electricity.. The chips are roughly a quarter of the size of a postage stamp. Stack five of them on top of each other and they can be used to generate the same voltage as two AA batteries. This can be produced simply by squeezing them together with your fingertips.. Additional nanowires and more nanogenerators, stacked together, could produce enough energy for powering larger electronics, such as an iPod or charging a cell phone. said Zhong Lin Wang, who heads up the research.. In a presentation at an American Chemical Society meeting in California, Wang said the device is 150 times more powerful than early prototypes.. This development represents a milestone toward producing portable electronics that can be powered by body movements without the use of batteries or electrical outlets… ...
Some teams have significantly accelerated the proliferation and differentiation of mouse embryonic bone-forming cells when using a so-called triboelectric nanogenerator. An electric current is generated when two materials are separated and then brought back into contact. These nanogenerators have been tested with materials such as polydimethylsiloxane, indiumtin oxide, aluminium, and polytetrafluoroethylene. They are showing potential for treating osteoporosis and osteoporosis-related fractures ...
The following is a listing of the USEPAs dose conversion factors for inhalation of some commonly-encountered radionuclides. The values shown below are in units of millirem per microcurie inhaled, and may be used to convert estimates of intake into committed effective dose equivalent. Included as well is a notation showing the applicable lung clearance class (i.e., Y = years, W = weeks, and D = days).. Actinium. ...
Actinium Pharmaceuticals says that exposing venetoclax-resistant AML cells to a CD33-targeted antibody radionuclide conjugate may resensitize cells to the drug and improve patient outcomes.
Protons Neutrons And Electrons For Helium - 28 images - Diagram Of The Atom Model Wedocable, How Are Elements Broken Into Protons Electrons And, Helium Atom Stock Photos Helium Atom Stock Images Alamy, Basic Chemistry Tutorial 2 Drawing Atoms Sciencemusicvideos, Element Diagram Of Helium Diagram Of Actinium Element
The product will be able to reduce redness and unevenness of complexion also. Should be easy to purchase If driving down to the drugstore every couple of days to purchase a new jar of the product is difficult, you should be able to obtain it home delivered then. A number of these products may be ordered on-line. Some products even provide a 30 day without risk trial to be able to try services at your leisure. It is created by This list easy for you to decide which products you require. Having the right age defying face creams ensures that you can start your skincare program as soon as possible.. 3 Criteria For FINDING THE RIGHT Anti Wrinkle Face Creams Are you noticing the first appearance of lines or wrinkles on your forehead or around the corners of your eye? Wrinkles are associated with advanced age group.His research passions include acute myeloid leukemia, radioimmunotherapy with alpha and beta particle-emitting radioisotopes, monoclonal antibody therapy for leukemia, development of novel ...
Late-onset Alzheimers disease (AD) accounts for the majority of AD cases. A characteristic feature of AD is the accumulation of β-amyloid (Aβ) plaques in the brain. Several mutations are associated with risk for late-onset AD, particularly mutations in the genes encoding apolipoproteins APOE4 and clusterin (also known as APOJ), which alter the metabolism and impair the clearance of Aβ. Mutations in the gene encoding TREM2 (triggering receptor expressed on myeloid cells 2), a protein with a single transmembrane domain that is present in microglia in the brain, are also associated with increased risk of AD. Yeh et al. found that the three risk factors are mechanistically linked. A protein microarray screen using a library of secreted ligands immobilized on glass slides and a fusion antibody construct containing the extracellular domain of TREM2 or TREM1 identified various lipoproteins as potential selective ligands of TREM2. These included low-density lipoprotein, lipidated APOE and lapidated ...
The encouraging preclinical results have led to the initiation of a clinical development program for 223RaCl2. Approval was obtained from the applicable institutional review boards, and all patients provided informed written consent before entering the clinical studies.. Phase 1A. A phase 1 study of single-dosage administration of escalating amounts of 223Ra in 25 patients with bone metastases from breast and prostate cancer was recently published (44). Dose-limiting hematologic toxicity was not observed. Dosages of 46, 93, 163, 213, or 250 kBq/kg were applied. Mild and reversible myelosuppression occurred with only grade 1 toxicity for thrombocytes at the two highest dose levels. Quality of life was evaluated at baseline and at 1, 4, and 8 weeks after injection, respectively. Pain relief was observed for all time points in ,50% of the patients. Furthermore, a decline in total serum alkaline phosphatase ,50%, accepted as a prognostic marker in metastatic prostate cancer, was observed among ...
By combining a new generation of piezoelectric nanogenerators with two types of nanowire sensors, researchers have created what are believed to be the first self-powered nanometer-scale sensing devices that draw power from the conversion of mechanical energy.
NEW YORK, Sept. 28, 2016-- Actinium Pharmaceuticals, Inc., a biopharmaceutical Company developing innovative targeted payload immunotherapeutics for the treatment of advanced cancers, announced today that it intends to offer shares of its common stock in an underwritten public offering. A preliminary prospectus supplement and accompanying prospectus...
for treating castration resistant prostate cancer and symptomatic bone metastases. From the website below: The active moiety of Xofigo is the alpha particle-emitting isotope radium 223 (as radium 223 dichloride), which mimics calcium and forms complexes with the bone mineral hydroxyapatite at areas of increased bone turnover, such as bone metastases. The high linear energy transfer of alpha emitters (80 keV/micrometer) leads to a high frequency of double-strand DNA breaks in adjacent cells, resulting in an anti-tumor effect on bone metastases. The alpha particle range from radium 223 dichloride is less than 100 micrometers (less than 10 cell diameters) which limits damage to the surrounding normal tissue. After intravenous injection, radium 223 is rapidly cleared from the blood and is distributed primarily into bone or is excreted into intestine. Fifteen minutes post-injection, about 20% of the injected radioactivity remained in blood. At 4 hours, about 4% of the injected radioactivity remained ...
Class: Radiopharmaceutical. Generic Name: Radium Ra 223 dichloride (RAY-dee-um Ra 223 dye-KLOR-ide). Trade Name: Xofigo®. For which conditions is this drug approved? Radium Ra 223 dichloride is indicated for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases, and no known visceral metastatic disease.. What is the mechanism of action? The active component of radium Ra 223 dichloride is the alpha particle-emitting isotope radium-223 (as radium Ra 223 dichloride), which mimics calcium and forms complexes with the bone mineral hydroxyapatite at areas of increased bone turnover, such as bone metastases The high linear energy transfer of alpha emitters (80 keV/micrometer) leads to a high frequency of double-strand DNA breaks in adjacent cells, resulting in an anti-tumor effect on bone metastases. The alpha particle range from radium-223 dichloride is less than 100 micrometers (less than 10 cell diameters), which limits damage to the surrounding normal ...
Bispecific T cell engager (BiTE®) antibody constructs are a type of immunotherapy being investigated for fighting cancer by helping the bodys immune system to detect and target malignant cells. The modified antibodies are designed to engage two different targets simultaneously, thereby juxtaposing T cells (a type of white blood cell capable of killing other cells perceived as threats) to cancer cells. BiTE® antibody constructs help place the T cells within reach of the targeted cell, with the intent of allowing T cells to inject toxins and trigger the cancer cell to die (apoptosis). BiTE® antibody constructs are currently being investigated for their potential to treat a wide variety of cancers. For more information, visit www.biteantibodies.com.. About ...
The development of nanogenerators (NGs) with optimal performances and functionalities requires more novel materials. Over the past decade, biopolymer nanofibers (BPNFs) have become critical sustainable building blocks in energy-related fields because they have distinctive nanostructures and properties and can be obtained from abundant and renewable resources. This review summarizes recent advances in the use of BPNFs for NG development. We will begin by introducing various strategies for fabricating BPNFs with diverse structures and performances. Then, we will systematically present the utilization of polysaccharide and protein nanofibers for NGs. We will mainly focus on the use of BPNFs to generate bulk materials with tailored structures and properties for assembling of triboelectric and piezoelectric NGs. The use of BPNFs to construct NGs for the generation of electricity from moisture and osmosis is also discussed. Finally, we illustrate our personal perspectives on several issues that require
A nanogenerator converts mechanical/thermal energy produced by small-scale physical changes into electricity. It has three typical approaches/types: piezoelectric, triboelectric and pyroelectric. Both piezoelectric and triboelectric nanogenerators can convert mechanical energy into electricity, and are used in medical devices.. A piezoelectric nanogenerator converts external kinetic energy into electrical energy via action by a nanostructured piezoelectric material such as ZnO, GaN, BaTiO3 and the like.. A triboelectric nanogenerator (TENG) is an energy-harvesting device that converts external mechanical energy into electricity by a conjunction of triboelectric effect and electrostatic induction. As for this power generation unit, in the inner circuit, a potential is created by triboelectric effect due to charge transfer between two thin organic/inorganic films that exhibit opposite tribo-polarity. In the outer circuit, electrons are driven to flow between two electrodes attached to the back of ...
In generating energy from movement, Wang says his team concluded that it was most effective to develop a method that worked at low frequencies and was based on flexible materials. The ZnO nanowires met these requirements. At the same time, he says a real advantage of this technology is that the nanowires can be grown easily on a wide variety of surfaces, and the nanogenerators will operate in the air or in liquids once properly packaged. Among the surfaces on which the nanowires can be grown are metals, ceramics, polymers, clothing and even tents ...
Two aspects of the radionuclide source terms used for total-system performance assessment (TSPA) analyses have been reviewed. First, a detailed radionuclide inventory (i.e., one in which the reactor type, decay, and burnup are specified) is compared with the standard source-term inventory used in prior analyses. The latter assumes a fixed ratio of pressurized-water reactor (PWR) to boiling-water reactor (BWR) spent fuel, at specific amounts of burnup and at 10-year decay. TSPA analyses have been used to compare the simplified source term with the detailed one. The TSPA-91 analyses did not show a significant difference between the source terms. Second, the radionuclides used in source terms for TSPA aqueous-transport analyses have been reviewed to select ones that are representative of the entire inventory. It is recommended that two actinide decay chains be included (the 4n+2 ``uranium`` and 4n+3 ``actinium`` decay series), since these include several radionuclides that have potentially important
Alpha particles are emitted mainly by the heaviest of the isotopes (e.g., all elements above bismuth (Bi-209) are radioactive, and most are alpha particle emitters. These nuclei are too big to be stable and decay by emitting an alpha particle. Very often the resulting nucleus, called a Daughter nucleus, is also too big and unstable. It too usually emits an alpha particle. This process can happen a number of times depending upon the starting isotope and the ultimate stable isotope. The stable isotope of the alpha emitters is usually lead (the element just below Bismuth, and has 4 stable isotopes for the Decay Chains to stop on). For example, the most abundant isotope of uranium, U-238, it takes the emission of 5 alpha particles to get to stable lead.. Alpha particles are high speed helium atoms without electrons. Consisting of a nucleus of 2 protons and 2 neutrons, this is the largest common (naturally occurring) radiation particle. Since there are no electrons, the alpha particle is highly ...
The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy.
Resonances in the yield of ground-state protons from alpha-particle bombardment of 31P were investigated in the energy range Eα = 1.7 − 3.3 MeV. Fourteen resonances were observed, none of which was known before. Resonance energies and strengths are presented. Angular distribution measurements lead to unique values of the resonance ... read more spin in all cases but one. The exception is the strong resonance at Eα = 3.302 MeV, which shows a deviation from forward-backward symmetry in the angular distribution, to be explained by assuming interference with some unknown broad resonance(s) with opposite parity, probably at higher energy. show less ...
Measured alpha particle hits per unit tumour area per 1 hour for two groups of tumour sections: 4 sections with and 3 sections without application of chemothera
Get an answer for Alpha radiation is a strong ionizer, but it can only penetrate through few cm of air. How then can alpha particles cause human biological damage? and find homework help for other Science questions at eNotes
An Alpha Particle Is Kept In An Electric Field Of 15×104Nc−1. Calculate The Force Acting On The Particle. An Electron Is Separated From A Proton Through A Distance Of 0.53A. Calculate Electric Field At The Location Of Electrons​. Get the answer to this question and access other important questions, only at BYJUS.
This is a single-arm, single-site pilot of Radium-223 (55 kBq/kg) IV q3 weeks for up to 6 doses in combination with Atezolizumab 1200mg IV once every 3 weeks
The larger and more charged the radiation the more ionizations occur. Alpha particles are very highly ionizing, thus would have a larger LET than a low energy gamma. Alpha particles will cause more biological damage in a very small area ...
Guided discovery of alpha particle deflection in gold foil vs. alpha particles. Activity focuses on Rutherfords experiment only and does not include Thomson model ...
Actinium-225 is less available than actinium-228, but is more promising in radiotracer applications. Actinium-227 (half-life ... The strongest base is of actinium. All compounds of actinium are colorless, except for black actinium sulfide (Ac2S3). Dioxides ... Owing to the close similarity of actinium and lanthanum and low abundance, pure actinium could only be produced in 1950. The ... The major difficulty in separation of actinium is the similarity of its properties with those of lanthanum. Thus actinium is ...
Actinium(III) chloride - AcCl3 Actinium(III) fluoride - AcF3 Actinium(III) oxide - Ac2O3 Aluminium antimonide - AlSb Aluminium ... "Actinium chloride". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-11-18. PubChem. "Actinium fluoride". pubchem.ncbi.nlm.nih.gov. ... CeZn Actinium(III) chloride - AcCl3 Aluminium chloride - AlCl3 Americium(III) chloride - AmCl3 Ammonium chloride - [NH4]Cl ...
"89 Actinium". Elements.vanderkrogt.net. Retrieved 2008-09-12. Kirby, Harold W. (1971). "The Discovery of Actinium". Isis. 62 (3 ...
Soddy, Frederick; Cranston, John A. (1 June 1918). "The parent of actinium". Proceedings of the Royal Society of London. Series ...
In the periodic table, it lies to the right of actinium, to the left of protactinium, and below cerium. Pure thorium is very ... These values lie between those of its neighbours actinium (10.1 g/cm3) and protactinium (15.4 g/cm3), part of a trend across ... It becomes superconductive below 1.4 K. Thorium's melting point of 1750 °C is above both those of actinium (1227 °C) and ... the actinium series), and slightly larger but still tiny traces of 234Th and 230Th from the decay chain of 238U (the uranium ...
He was aware of the discovery of actinium by André-Louis Debierne. In publications from 1899 and 1900 Debierne does not give ... In a now controversially reviewed process, it was stated that emanium is identical to actinium, which was discovered by André- ... Giesel, on the other hand, can rightfully be credited with the first preparation of radiochemically pure actinium and with the ... Adloff, J. P. (2000). "The centenary of a controversial discovery: actinium". Radiochim. Acta. 88 (3-4_2000): 123-128. doi: ...
Radium, and Other Radio-active Substances; Polonium, Actinium, and Thorium is a book published in 1903 by William Joseph Hammer ... In addition to the matters implied by the title of the lecture, (radium, polonium, actinium, thorium) Hammer discusses such ... "Radium, and other radio-active substances; polonium, actinium, and thorium. With a consideration of phosphorescent and ... Radium and Other Radioactive Substances, Polonium, Actinium and Thorium, with a Consideration of Phosphorescent and Fluorescent ...
... actinium Rehder, 1980. Retrieved through: World Register of Marine Species on 17 May 2010. Cerithidium australiense ... Cerithidium actinium Rehder, 1980 Cerithidium australiense Thiele, 1930 Cerithidium cerithinum (Philippi, 1849) Cerithidium ...
This research resulted in the successful identification of a new element in the decay chain between uranium-235 and actinium, ... Soddy, F.; Cranston, J. A. (1 June 1918). "The Parent of Actinium". Proceedings of the Royal Society A: Mathematical, Physical ... on the possible modes of origin of actinium. With regard to the new work, in the absence of one of us on military service since ...
Actinium-225 Actinium series Bismuth-213 Isotopes of radium Radium chloride Wang M, Audi G, Kondev FG, Huang WJ, Naimi S, Xu X ... which decays with a 42-minute half-life to actinium-227. Actinium-227 (half-life 21.8 years) in turn decays via thorium-227 ( ... It was discovered in 1905 by T. Godlewski, a Polish chemist from Kraków, and was historically known as actinium X (AcX). Radium ... This decay path makes it convenient to prepare radium-223 by "milking" it from an actinium-227 containing generator or "cow", ...
He is often considered the discoverer of the element actinium, though H. W. Kirby disputes this and awards credit instead to ... In 1899, he discovered the radioactive element actinium, as a result of continuing the work with pitchblende that the Curies ... Kirby, H. W. (1971). "The Discovery of Actinium". Isis. 62 (3): 290-308. doi:10.1086/350760. JSTOR 229943. S2CID 144651011. ... Actinium, ESPCI Paris alumni, 19th-century French chemists, All stub articles, French chemist stubs). ...
In 1903, similar emanations were observed from actinium by André-Louis Debierne, and were called "actinium emanation" ("Ac Em ... Similarly, 219Rn is derived from the most stable isotope of actinium (227Ac)-named "actinon"-and is an alpha emitter with a ... Adams, Elliot Quincy (1920). "The Independent Origin of Actinium". Journal of the American Chemical Society. 42 (11): 2205. doi ...
Cousinia actinia Boiss. Cousinia adenophora Juz. Cousinia adenostegia Rech.f. Cousinia adenosticta Bornm. Cousinia adnata Bunge ...
Passiflora actinia Hook. Passiflora alata Dryand. Passiflora amethystina J.C.Mikan Passiflora deidamioides Harms Passiflora ...
Actinium by André-Louis Debierne in 1899. Discovery of the Grignard reaction or Grignard reagent by Victor Grignard in 1900. ...
Actinium is discovered by André-Louis Debierne. International Committee on Atomic Weights established. January 23 - The British ...
A possible relation between uranium and actinium. Nature, Lond. 87, 515. (1911) On the bending of electric waves round a large ...
... which was long regarded as a variety of Actinia equina (also called Actinia mesembryanthemum in Dalyell's day). The strawberry ... "Beadlet Anemone, Actinia equina (British Marine Life Study Society)". www.glaucus.org.uk. Archived from the original on 11 ... From 1790 Dalyell had led the way in keeping marine creatures and had kept an Actinia sea anemone as early as 1805, which by ... Despite this, there is no consistent evidence of sexual reproduction in Actinia equina. In any case, after she had been caught ...
A further study in 2000 concluded that Actinia priapus; Tilesius, 1809, Actinia farcimen; Brandt, 1835, and Isometridium ... Of these, Actinia farcimen was the name first published. It is, however, a junior homonym so the valid name for the species is ...
Cotelle "collaborated with Curie on studies of actinium. With Curie she redetermined the half-life of ionium using a method ...
Eighty-nine is: The atomic number of actinium. Messier object M89, a magnitude 11.5 elliptical galaxy in the constellation ...
Actinium(III) is eleven-coordinate in aqueous solution. Thorium(IV) is nine-coordinate tricapped trigonal prismatic, and it is ... Thierer, Laura M.; Tomson, Neil C. (2017). "The Actinium Aqua Ion: A Century in the Making". ACS Cent. Sci. 3 (3): 153-155. doi ...
"The Actinium Series and the Lead Ratios in Rocks." Nature 117 (1926): 719-720. doi:10.1038/117719b0 with W. M. Rayton: " ...
Secondary decay products of thorium include radium and actinium. Because of this, there are concerns about the safety of ...
Stern, A. (1934). "The new element bohemium the origin of proto-actinium". Journal of the Society of Chemical Industry. 53: 581 ...
Hahn pursued a report by Stefan Meyer and Egon Schweidler of a decay product of actinium with a half-life of about 11.8 days. ... Hahn was thinking only of actinium, but on reading his paper, Meitner told him that he had found a new way of detecting ... However, it was a beta emitter, and therefore could not be the mother isotope of actinium. This had to be another isotope of ... There was one isotope known to have a half life of 6.2 hours, mesothorium II (actinium-228). This was not in any probable decay ...
In nature, it is found in trace amounts as part of the actinium series, which starts with the primordial isotope uranium-235; ... The primary decay products of 231Pa and isotopes of protactinium lighter than and including 227Pa are isotopes of actinium and ... Plus radium (element 88). While actually a sub-actinide, it immediately precedes actinium (89) and follows a three-element gap ... "Discovery of the Actinium, Thorium, Protactinium, and Uranium Isotopes." January 14, 2012. Accessed May 20, 2018. https:// ...
a This "Ac" is not referring to the element actinium. Used in this way, the convention in organic chemistry is for Ac to refer ...
207Pb is the end of the actinium series from 235U. 208Pb is the end of the thorium series from 232Th. While it only makes up ... Final decay product of 4n+3 decay chain (the Actinium series) Experimental lower bound is τ 1 / 2 > 1.9 × 10 21 {\displaystyle ... the actinium series, and the thorium series, respectively; a fourth decay chain, the neptunium series, terminates with the ...
The actinium-225 is made by the irradiation of radium-226 with a cyclotron. Buscombe, J.; Navalkissoor, S. (1 August 2012). " ... This is made by the alpha decay of actinium-225. The generation of one short-lived isotope from longer lived isotope is a ... Morgenstern, Alfred; Bruchertseifer, Frank; Apostolidis, Christos (1 June 2012). "Bismuth-213 and Actinium-225 - Generator ...
The isotopes of actinium range in atomic weight from 205 u (205 Ac) to 236 u (236 Ac). Actinium is found only in traces in ... Actinium gave the name to the actinide series, a group of 15 similar elements between actinium and lawrencium in the periodic ... The actinium isotope 227Ac is a transient member of the uranium-actinium series decay chain, which begins with the parent ... Actinium metal has been prepared by the reduction of actinium fluoride with lithium vapor in vacuum at a temperature between ...
This WebElements periodic table page contains electronegativity for the element actinium ... The first scale of electronegativity was developed by Linus Pauling and on his scale actinium has a value of 1.1 on a scale ... Actinium - 89Ac Your user agent does not support the HTML5 Audio element. 🔊 ... Types of electronegativity for actinium. All values are quoted on the Pauling scale.. Electronegativity. Value in Pauling units ...
You do not have permission to edit this page, for the following reason: ...
of Actinium Pharmaceuticals, Inc common stock. In the last 4 years at Actinium Pharmaceuticals, Inc, Sergio Traversa has sold ... What are Actinium Pharmaceuticals, Incs Past Insider Trades?. Actinium Pharmaceuticals, Incs most recent insider trade came ... In the last 5 years, insiders at Actinium Pharmaceuticals, Inc have sold an estimated value of $2.28M and bought an estimated ... Actinium Pharmaceuticals, Inc. Insider Trades. Applied Filters:. Trade Types: p, sTicker: atnmGroup By: filingSort By: last_ ...
Detailed decay information for the isotope actinium-230 including decay chains and daughter products. ... Actinium Pictures Page. Al. Si. P. S. Cl. Ar. K. Ca. Actinium Technical Data. Sc. Ti. V. Cr. Mn. Fe. Co. Ni. Cu. Zn. Ga. Ge. As ... Isotopes of Actinium (click to see decay chain):. 206Ac 207Ac 208Ac 209Ac 210Ac 211Ac 212Ac 213Ac 214Ac 215Ac 216Ac 217Ac 218Ac ... Actinium Main Page. Black White Gray. B. C. N. O. F. Ne. ...
RTTNews) - Actinium Pharmaceuticals Inc. (ATNM) said that it has made material advances in its key clinical trials and programs ... Actinium reported a cash balance of $48.2 million as of September 30, 2020 compared with $9.2 million as of December 31, 2019. ... RTTNews) - Actinium Pharmaceuticals Inc. (ATNM) said that it has made material advances in its key clinical trials and programs ... Actinium Sees Multiple Milestones In Q4 From ARC Pipeline Incl Phase 3 Data From SIERRA Trial ...
The following pages link to Actinium/Electron configuration: Displayed 2 items. View (previous 50 , next 50) (20 , 50 , 100 , 250 , 500) ...
While actinium-225 is considered an important potential therapy, its not the only actinium isotope thats found a use; ... The review is particularly important given actinium-225s increasing promise as an anti-cancer therapy. Complexes of actinium ... Actinium was discovered by French chemist André-Louis Debierne in 1899. But it exists in such small quantities naturally - ... The ionic radius of actinium(III) may be far smaller and closer to the lanthanides than the most recent measurements from the ...
Detailed decay information for the isotope actinium-208 including decay chains and daughter products. ... Actinium Pictures Page. Al. Si. P. S. Cl. Ar. K. Ca. Actinium Technical Data. Sc. Ti. V. Cr. Mn. Fe. Co. Ni. Cu. Zn. Ga. Ge. As ... Isotopes of Actinium (click to see decay chain):. 206Ac 207Ac 208Ac 209Ac 210Ac 211Ac 212Ac 213Ac 214Ac 215Ac 216Ac 217Ac 218Ac ... Actinium Main Page. Black White Gray. B. C. N. O. F. Ne. ...
An analysis of the nematocysts of the beadlet anemone Actinia equina and the green sea anemone Actinia prasina. Journal of the ... Actinia equina (Linnaeus, 1758). Accessed through: Odido, M.; Appeltans, W.; BelHassen, M.; Mussai, P.; Nsiangango, S.E.; ... additional source Schama, R.; Mitchell, M.; Solé-Cava, A. M. (2011). Actinia ebhayiensis sp. nov., a new species of sea anemone ... additional source den Hartog, J.C. & Ocaña, O. (2003). A new endemic Actinia species (Actiniaria: Actiniidae) from the central ...
2022 actinium Consulting AG. Robert-Bosch-Straße 28. 88131 Lindau, Germany. Telefon: +49 (0) 8382-277 278-0. E-Mail: [email protected] ...
... github.com/mundialis/actinia_core/releases/download/4.2.0/actinia_core-4.2.0-py2.py3-none-any.whl" pip3 install "actinia-api @ ... raw.githubusercontent.com/mundialis/actinia_core/main/requirements.txt python3 -m actinia_core.main A running redis instance is ... Update the actinia installer to use the above pip install (but needs to go into a separate virtualenv). Then add a section to ... Since the deadline for RC1 is this weekend, the PSC has decided to move actinia to VM only. There is no time to prepare debian ...
Actinia elongata Delle Chiaje, 1825. T4042054 Quick-Link [ https://copepedia.org/?id=T4042054 ]. Species ( WoRMS-Aphia: 0100802 ...
Mark Berger, Actiniums Chief Medical Officer, said in the release. "All of us at Actinium are intensely focused on completing ... Thats where companies like Actinium Pharmaceuticals, Inc. ATNM come in. Actinium provides treatment options for cancer ... Similar to Actinium, Novartis NVS and Fusion Pharmaceuticals FUSN have targeted radiotherapies. Whereas Gilead Sciences GILD ... Actinium has established itself as a leader in the targeted radiotherapy field, pursuing several hematology targets with late- ...
2022 actinium Consulting AG. Robert-Bosch-Straße 28. 88131 Lindau, Germany. Telefon: +49 (0) 8382-277 278-0. E-Mail: [email protected] ...
actinium, CANCER, Chelates, macrocycles, RADIOPHARMACEUTICALS. Abstract. Abstract The 18-membered macrocycle H2macropa was ...
XLY urlsufc -> /collections/mountain-biking-helmets-dirt-jump/color-actinium-pink-matt ...
Actinia artemisia Pickering in Dana, 1846. Accessed through: World Register of Marine Species at: https://www.marinespecies.org ...
Actinium Pharmaceuticals actualites et ATNM prix. Prix en temps réel gratuits, échanges, et forum. ... Actinium Pharmaceuticals (ATNM) Gets a Buy Rating from H.C.... 08/12/2021. 17:39. TRMN. Actinium Pharmaceuticals (ATNM) Gets a ... Actinium Up After Positive Topline Clinical Data. 31/10/2022. 12:35. TRMN. Actinium Pharmaceuticals (ATNM) Receives a Buy from ... Actinium Pharmaceuticals (ATNM) Receives a Buy from Alliance... 25/4/2022. 16:55. TRMN. Actinium Pharmaceuticals (ATNM) Gets a ...
ATNM Actinium Pharmaceuticals Inc Maxim Group Sticks to Their Buy Rating for Actinium Pharmaceuticals (ATNM) ... The word on The Street in general, suggests a Moderate Buy analyst consensus rating for Actinium Pharmaceuticals with a $35.00 ... Actinium Pharmaceuticals (AMEX:ATNM). Historical Stock Chart. From Oct 2022 to Nov 2022 ... Actinium Pharmaceuticals (AMEX:ATNM). Historical Stock Chart. From Nov 2021 to Nov 2022 ...
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Actinium-225 is an alpha-emitting radionuclide with significant promise in effectively treating cancer patients. It can be ... TerraPower and Cardinal Health announce manufacturing and distribution agreement for Actinium-225. By TerraPower MediaAugust 12 ... The current global supply of Actinium-225 is very limited but with this agreement, it is anticipated that the companies will be ... Under the agreement, the companies will work together to develop and produce Actinium-225 for use in drug development and ...
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Actinium; Genentech; Immunogen; BerGenBio. Received research grant from: AbbVie; Astellas; Daiichi Sankyo; Syndax; FujiFilm ...
Compare Tungsten vs Actinium of the Periodic Table on all their Facts, Electronic Configuration, Chemical, Physical, Atomic ... Actinium. vs PlutoniumActinium. vs NeptuniumActinium. vs AmericiumActinium. vs FermiumActinium. vs ActiniumActinium. vs ... UraniumActinium. vs EinsteiniumActinium. vs CeriumActinium. vs NeodymiumActinium. vs TerbiumActinium. vs HolmiumActinium. vs ... PlutoniumActinium. vs NeptuniumActinium. vs AmericiumActinium. vs FermiumActinium. vs ThuliumActinium. vs LanthanumActinium. vs ...
Actinium-225 is the preferred radionuclide as it is an alpha emitter and has both high LET and RBE almost 100 times more than ... Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a ... The generation of high-energy protons is crucial in producing actinium as shown in the previous figure. To produce high-energy ... Supply and clinical application of actinium-225 and bismuth-213. Semin. Nucl. Med.. 50. 2. 119. 123. 10.1053/j.semnuclmed. ...
Click to add description. Lorem ipsum dolor sit amet, consectetur adipiscing elit. ...
  • Specimens added as distinct forms of the Actinia equina complex. (aphotomarine.com)
  • The Beadlet anemone ( Actinia equina ) is a common sea anemone found on rocky shores around all coasts. (intotheblue.link)
  • Actinia equina can be found both in exposed and sheltered situations. (intotheblue.link)
  • Actinia equina is similar in form to the Waratah anemone (Actinia tenebrosa) of Australia and New Zealand. (intotheblue.link)
  • This project will use the common intertidal beadlet anemone Actinia equina as a powerful model system for examining these issues. (quadrat.ac.uk)
  • In this project you will combine extensive fieldwork along Scottish and Irish coasts with controlled microcosm experiments in the lab and state-of-the-art molecular tools to identify functional genomic differences between Actinia equina morphs. (quadrat.ac.uk)
  • Also found on the bedrock is the barnacle Chthamalus stellatus or the limpet Patella vulgata , while numerous cracks and crevices provide shelter for anemones such as Actinia equina or the mussel Mytilus edulis . (europa.eu)
  • RTTNews) - Actinium Pharmaceuticals Inc. (ATNM) said that it has made material advances in its key clinical trials and programs for targeted conditioning and therapeutic combinations this year and anticipate several important milestones before year-end and in 2021. (nasdaq.com)
  • That's where companies like Actinium Pharmaceuticals, Inc. ATNM come in. (benzinga.com)
  • Actinium Pharmaceuticals (ATNM) Gets a Buy from H.C. (advfn.com)
  • Actinium Pharmaceuticals (ATNM) Receives a Buy from B.Riley. (advfn.com)
  • Actinium Pharmaceuticals (ATNM) Has a New Rating from. (advfn.com)
  • Actinium Pharmaceuticals (ATNM) Received its Third Buy in a. (advfn.com)
  • Maxim Group analyst Jason McCarthy maintained a Buy rating on Actinium Pharmaceuticals (ATNM - Research Report) yesterday and set a price target of $25.00. (advfn.com)
  • Is Actinium Pharmaceuticals (ATNM) Outperforming Other Medical Stocks This Year? (fedmich.com)
  • Is a Surprise Coming for Actinium Pharmaceuticals (ATNM) This Earnings Season? (fedmich.com)
  • Actinium Pharmaceuticals (ATNM) is a Great Momentum Stock: Should You Buy? (fedmich.com)
  • Is Actinium Pharmaceuticals (ATNM) Stock Outpacing Its Medical Peers This Year? (fedmich.com)
  • Actinium Pharmaceuticals, Inc. (ATNM:NYSEMKT) jumped higher at $13.54 , representing a gain of 39.2% . (stocktreats.com)
  • During my meeting with Actinium Pharmaceuticals (ATNM) we delved deeper into the topic I covered via a separate article last week - the clinical hold placed on Seattle Genetics SGN-CD33A. (bionapcfa.com)
  • NEW YORK , April 11, 2022 /PRNewswire/ -- Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) ("Actinium" or the "Company"), a leader in the development of targeted radiotherapies for patients with unmet needs, today announced positive results from preclinical studies evaluating an anti-HER3 antibody, conjugated with an Actinium-225 (Ac-225) radioisotope payload, for targeting HER3-positive non-small cell lung cancer (NSCLC) cells. (actiniumpharma.com)
  • Actinium is found only in traces in uranium and thorium ores as the isotope 227Ac, which decays with a half-life of 21.772 years, predominantly emitting beta and sometimes alpha particles, and 228Ac, which is beta active with a half-life of 6.15 hours. (wikipedia.org)
  • One tonne of natural uranium in ore contains about 0.2 milligrams of actinium-227, and one tonne of thorium contains about 5 nanograms of actinium-228. (wikipedia.org)
  • Since 2018, TerraPower has been working to increase supply of Actinium-225 from Thorium-229 decay, which is derived from legacy U.S. nuclear material. (terrapower.com)
  • Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix. (ornl.gov)
  • The subject of radioactivity deals with phenomena exhibited by a special class of bodies of high atomic weight of which uranium, thorium, radium and actinium are the best known examples. (wikisource.org)
  • Polonium and astatine, as well as the next four elements (radon, francium, radium, and actinium) have in common the fact that were it not by the grace of there still being original uranium and thorium in existence…they wouldn't exist either. (home.blog)
  • Together with polonium, radium, and radon, actinium was one of the first non-primordial radioactive elements to be isolated. (wikipedia.org)
  • This, Deblonde and colleagues conclude, is likely due to the complexity of working with of actinium - which has few spectroscopic features, is colourless, not fluorescent and diamagnetic, as well as incredibly short-lived - and the probable contamination of the sample with traces of radium. (chemistryworld.com)
  • actinium-227 is essential as a precursor to radium-223, a chemotherapy agent approved in more than 50 countries. (chemistryworld.com)
  • Basically alpha emitters like Radium-223, Actinium are used for this therapy which deposits high amounts of energies in tumor cells leading to their death. (manipalhospitals.com)
  • Similarly for radon, radium, and actinium. (home.blog)
  • The new name meant "(nuclear) precursor [6] of actinium " and reflected that actinium is a product of radioactive decay of protactinium. (wikipedia.org)
  • Small amounts of actinium and Protactinium can be discovered in nature as breakdown products of 253 and 238-Uranium. (aakash.ac.in)
  • In the periodic table , it lies to the right of actinium, to the left of protactinium, and below cerium. (wikiversity.org)
  • Under the agreement, the companies will work together to develop and produce Actinium-225 for use in drug development and commercial sales. (terrapower.com)
  • Working together, the companies will develop and produce Actinium-225, which will be utilized in drug trials involving targeted alpha therapy for diseases such as breast, prostate, colon and neuroendocrine cancers, melanoma and lymphoma. (na-biz.com)
  • October 11, 2022 - Eckert & Ziegler Isotope Technologies Dresden (ITD), a specialist in radiopharmaceutical plant engineering and a wholly owned subsidiary of Eckert & Ziegler AG (ISIN DE0005659700, SDAX) and NorthStar Medical Radioisotopes, LLC, a global innovator in the development, production and commercialization of radiopharmaceuticals used for therapeutic applications and medical imaging, today announced an agreement to purchase hot cells and related equipment for actinium-225 (Ac -225) production site. (astoundingweb.org)
  • the half-life of its most stable isotope, actinium-227, is 21.8 years. (jrank.org)
  • That's what got him into the medical physics program, where he's researching the production and applications of the radioactive isotope actinium-225 at TRIUMF, Canada's particle accelerator centre, located at UBC. (ubc.ca)
  • The next year, she was given her own lab at KWI, where she started to search for the 'mother isotope' of actinium. (findingada.com)
  • TPI has unique access to Actinium-225 and is working to provide this isotope to the pharmaceutical community for the development of drugs that target and treat cancer. (greencarcongress.com)
  • Actinium-225 (225Ac, Ac-225) is an isotope of actinium. (nuclearphoenix.xyz)
  • We look forward to sharing these data, which show the efficacy for our novel approach of conjugating Actinium-225 to a HER3 antibody at AACR 2022. (actiniumpharma.com)
  • The first scale of electronegativity was developed by Linus Pauling and on his scale actinium has a value of 1.1 on a scale running from from about 0.7 (an estimate for francium) to 2.20 (for hydrogen) to 3.98 (fluorine). (webelements.com)
  • Vlad joined Actinia part-time in July 2021 as a crystal growth and device fabrication scientist while working as a postdoctoral fellow at Northwestern University. (actiniadetectors.com)
  • The current global supply of Actinium-225 is very limited but with this agreement, it is anticipated that the companies will be able to significantly increase availability of the radionuclide. (terrapower.com)
  • The problem is that the supply of actinium-225 is limited. (ubc.ca)
  • Our collaboration with Cardinal Health brings us another step closer to increasing access to Actinium-225 and making advanced treatments available to patients. (terrapower.com)
  • It is also similar in form to the strawberry anemone (Actinia fragacea) but is a uniform colour and is typically rather smaller. (intotheblue.link)
  • Chromogenic proteins or chromoproteins are colored proteins that have been extracted from a variety of organisms such as the sea anemone, Actinia equine [2] or have been synthetically produced (as was the case for the chromoproteins from DNA2.0). (igem.org)
  • A soft, silvery-white radioactive metal, actinium reacts rapidly with oxygen and moisture in air forming a white coating of actinium oxide that prevents further oxidation. (wikipedia.org)
  • it seems that the radioactive Actinium was the fuel for the work that I need to do. (artvilla.com)
  • Then add a section to the quickstart to use the local actinia deployment instead of the remote one. (osgeo.org)
  • Do not change the installer this year but add a section to the quickstart with docker instructions (docker is now available on the VM version) so that users can run actinia through docker as an exercise. (osgeo.org)
  • Actinium has similar chemical properties to lanthanum and other lanthanides, and therefore these elements are difficult to separate when extracting from uranium ores. (wikipedia.org)
  • Actinium is a chemical element discovered by a group of French scientists by extraction from uranium ores. (atomicnumber.net)
  • The features of the extraction and separation of rare-earth and associated elements in ores (actinium, yttrium) by extraction with mixtures of cation-exchange and anion-exchange extractants are considered. (rudmet.ru)
  • As with most lanthanides and many actinides, actinium assumes oxidation state +3 in nearly all its chemical compounds. (wikipedia.org)
  • The first element of the actinides, actinium gave the set its name, much as lanthanum had done for the lanthanides. (wikipedia.org)
  • Another row with the element Actinium, the Actinides are a group of elements having atomic numbers 89 to 103. (aakash.ac.in)
  • Despite the fact that actinium (Z = 89) contains no 5 f electrons, It is studied under f-block elements and actinides are commonly used to study it due to its resemblance in properties with other elements. (aakash.ac.in)
  • Actinium gave the name to the actinide series, a group of 15 similar elements between actinium and lawrencium in the periodic table. (wikipedia.org)
  • To judge from where they seemed to sit in the periodic table, the elements after number 89, actinium, should behave like transition metals. (rsc.org)
  • They get their name from the fact that they are the next element after actinium (Ac) in the periodic table. (aakash.ac.in)
  • The close similarity of physical and chemical properties of actinium and lanthanum makes separation of actinium from the ore impractical. (wikipedia.org)
  • For some elements (yttrium, actinium), there is a shift in the position of an element in the REE series in terms of distribution co efficients, which consists in the fact that during extraction with one extractant, the distribution coefficient of this element is closer to lanthanum, and with the other extractant, closer to lutetium. (rudmet.ru)
  • Sandesh Seth, Chairman and CEO of Actinium, stated, "We are excited to continue to demonstrate Actinium's enhanced R&D capabilities and commitment to developing potent radiotherapies targeting solid tumors. (actiniumpharma.com)
  • Sandesh Seth is the executive chairman of Actinium Pharmaceuticals Inc., a biopharmaceutical company developing innovative, targeted payload radioimmunotherapeutics for the treatment of advanced cancers. (streetwisereports.com)
  • Melting point of Actinium is 1047 °C and its the boiling point is 3197 °C. (atomicnumber.net)
  • What is the Boiling Point of Actinium? (atomicnumber.net)
  • Actinium boiling point is 3197 °C . Boiling point of Actinium in Kelvin is 3471 K. (atomicnumber.net)
  • Actinium melting point is 1047 °C . Melting point of Actinium in Kelvin is 1323 K. (atomicnumber.net)
  • This article demonstrates cross-pollination of ideas between radiopharmaceutical chemistry and classical inorganic chemistry with radiotherapeutic work renewing the interest in inorganic chemistry of actinium,' Dadachova adds. (chemistryworld.com)
  • But what's really exciting and what really drew me into the company was the early data associated with the antibody coupled to actinium-225, which is an alpha-emitting radiopharmaceutical. (urotoday.com)
  • Owing to its strong radioactivity, actinium glows in the dark with a pale blue light, which originates from the surrounding air ionized by the emitted energetic particles. (wikipedia.org)
  • Using groundbreaking, environmentally friendly electron accelerator technology, NorthStar is poised to become the first commercial-scale producer of therapeutic radioisotopes actinium-225 (Ac-225) and copper-67 (Cu -67). (astoundingweb.org)
  • Actinium has 7 occupied electron shells and atomic mass of 227. (threadless.com)
  • Actinium Pharmaceuticals Inc is a biopharmaceutical company engaged in the development of innovative-targeted therapies for patients with cancers lacking effective treatment options. (stocktreats.com)
  • Actinium Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company developing targeted radiotherapies to deliver cancer-killing radiation with cellular level precision to treat patients with high unmet needs not addressed by traditional cancer therapies. (actiniumpharma.com)
  • Instead, researchers rely on actinium created in nuclear reactors. (chemistryworld.com)
  • There is incredible growth projected for the nuclear medicine industry over the next 5-10 years, with much of that growth coming in the area of theranostics 1 , which combines a diagnostic and therapeutic together for individualized patient treatment at the cellular level, like the radiolabeled Actinium-225 drugs," said Tiffany Olson, president of Nuclear & Precision Health Solutions at Cardinal Health. (terrapower.com)
  • Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. (sciendo.com)
  • Actinium reported a cash balance of $48.2 million as of September 30, 2020 compared with $9.2 million as of December 31, 2019. (nasdaq.com)
  • Actinium is a chemical element with the symbol Ac and atomic number 89. (wikipedia.org)
  • Its symbol Ac is also used in abbreviations of other compounds that have nothing to do with actinium, such as acetyl, acetate and sometimes acetaldehyde. (wikipedia.org)
  • Chemical symbol for Actinium is Ac. (atomicnumber.net)
  • Radiometric evaluation of diglycolamide resins for the chromatographic separation of actinium from fission product lanthanide. (ornl.gov)
  • Actinium was discovered by French chemist André-Louis Debierne in 1899. (chemistryworld.com)
  • The word on The Street in general, suggests a Moderate Buy analyst consensus rating for Actinium Pharmaceuticals with a $35.00 average price target, a 480.43% upside from current levels. (advfn.com)
  • Complexes of actinium with a chelating dodecane tetraacetic acid ligand (Dota) are being investigated in several types of cancer. (chemistryworld.com)
  • This correction very nicely explains why the actinium cation fits into the cavity of Dota ligand, for which it is supposed to be too large,' says Ekaterina Dadachova , a pharmacy researcher at the University of Saskatchewan, Canada, who specialises in radiotherapies. (chemistryworld.com)
  • This is an antibody associated with actinium-225, which is an alpha emitter. (urotoday.com)
  • By creating an avenue for the production of actinium, he hopes that other researchers who are looking at the isotope's application in treatment therapies can complete their projects. (ubc.ca)
  • Under this agreement, Cardinal Health will produce and distribute TerraPower's Actinium-225 product, which will be utilized in drug trials involving targeted alpha therapy for diseases such as breast, prostate, colon and neuroendocrine cancers, melanoma and lymphoma. (terrapower.com)
  • Drugs containing actinium-225 have shown remarkable potential for the treatment of aggressive cancers. (ubc.ca)
  • The revised ionic radius put forth in this study will be of significant value to the research community, especially in light of the very promising therapeutic properties of actinium-225. (chemistryworld.com)
  • 4 transactions over 4 years of their time at Actinium Pharmaceuticals, Inc. Sergio Traversa usually trades in March, with the busiest year in 2016, 2013, 2015 and 2017. (benzinga.com)