Actin-Related Protein 3: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.Actin-Related Protein 2: A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Actin-Related Protein 2-3 Complex: A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Vitamin K Epoxide Reductases: OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.Mediator Complex: A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Wiskott-Aldrich Syndrome Protein: WASP protein is mutated in WISKOTT-ALDRICH SYNDROME and is expressed primarily in hematopoietic cells. It is the founding member of the WASP protein family and interacts with CDC42 PROTEIN to help regulate ACTIN polymerization.Wiskott-Aldrich Syndrome Protein, Neuronal: A member of the Wiskott-Aldrich syndrome protein family that is found at high levels in NERVE CELLS. It interacts with GRB2 ADAPTOR PROTEIN and with CDC42 PROTEIN.Microfilament Proteins: Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.Rodenticides: Substances used to destroy or inhibit the action of rats, mice, or other rodents.Actin Cytoskeleton: Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.Rodent Control: The reduction or regulation of the population of noxious, destructive, or dangerous rodents through chemical, biological, or other means.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Miller Fisher Syndrome: A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Actin Depolymerizing Factors: A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. They remodel the actin CYTOSKELETON by severing ACTIN FILAMENTS and increasing the rate of monomer dissociation.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Cytoskeletal Proteins: Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.CapZ Actin Capping Protein: An actin capping protein that binds to the barbed-ends of ACTIN filaments. It is a heterodimer consisting of an alpha and a beta subunit. It regulates actin assembly by stabilizing actin oligomers for elongation. In SKELETAL MUSCLE, CapZ is localized to the Z-disk.Equipment Design: Methods of creating machines and devices.Cytoskeleton: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.Centrosome: The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).Immunological Synapses: The interfaces between T-CELLS and ANTIGEN-PRESENTING CELLS. Supramolecular organization of proteins takes place at these synapses involving various types of immune cells. Immunological synapses can have several functions including LYMPHOCYTE ACTIVATION; enhancing, balancing, or terminating signaling; or directing cytokine secretion.Microtubule-Organizing Center: An amorphous region of electron dense material in the cytoplasm from which the MICROTUBULES polymerization is nucleated. The pericentriolar region of the CENTROSOME which surrounds the CENTRIOLES is an example.Pseudopodia: A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Waiting Lists: Prospective patient listings for appointments or treatments.Trees: Woody, usually tall, perennial higher plants (Angiosperms, Gymnosperms, and some Pterophyta) having usually a main stem and numerous branches.STAT3 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Health Priorities: Preferentially rated health-related activities or functions to be used in establishing health planning goals. This may refer specifically to PL93-641.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Research Personnel: Those individuals engaged in research.Health Care Rationing: Planning for the equitable allocation, apportionment, or distribution of available health resources.Research Support as Topic: Financial support of research activities.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.National Institutes of Health (U.S.): An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.Ethics Committees, Research: Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.United States
(1/259) Actin polymerization: Where the WASP stings.

How do extracellular signals induce actin polymerization, as required for many cellular responses? Key signal transducers, such as the small GTPases Cdc42 and Rac, have now been shown to link via proteins of the WASP family to the Arp2/3 complex, which nucleates actin polymerization.  (+info)

(2/259) Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex.

The Arp2/3 complex, a stable assembly of two actin-related proteins (Arp2 and Arp3) with five other subunits, caps the pointed end of actin filaments and nucleates actin polymerization with low efficiency. WASp and Scar are two similar proteins that bind the p21 subunit of the Arp2/3 complex, but their effect on the nucleation activity of the complex was not known. We report that full-length, recombinant human Scar protein, as well as N-terminally truncated Scar proteins, enhance nucleation by the Arp2/3 complex. By themselves, these proteins either have no effect or inhibit actin polymerization. The actin monomer-binding W domain and the p21-binding A domain from the C terminus of Scar are both required to activate Arp2/3 complex. A proline-rich domain in the middle of Scar enhances the activity of the W and A domains. Preincubating Scar and Arp2/3 complex with actin filaments overcomes the initial lag in polymerization, suggesting that efficient nucleation by the Arp2/3 complex requires assembly on the side of a preexisting filament-a dendritic nucleation mechanism. The Arp2/3 complex with full-length Scar, Scar containing P, W, and A domains, or Scar containing W and A domains overcomes inhibition of nucleation by the actin monomer-binding protein profilin, giving active nucleation over a low background of spontaneous nucleation. These results show that Scar and, likely, related proteins, such as the Cdc42 targets WASp and N-WASp, are endogenous activators of actin polymerization by the Arp2/3 complex.  (+info)

(3/259) Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation.

Using both light and high resolution electron microscopy, we analyzed the spatial and temporal relationships between the Arp2/3 complex and the nucleation activity that is required for lamellipod extension in mammary carcinoma cells after epidermal growth factor stimulation. A rapid two- to fourfold increase in filament barbed end number occurs transiently after stimulation and remains confined almost exclusively to the extreme outer edge of the extending lamellipod (within 100-200 nm of the plasma membrane). This is accompanied by an increase in filament density at the leading edge and a general decrease in filament length, with a specific loss of long filaments. Concomitantly, the Arp2/3 complex is recruited with a 1.5-fold increase throughout the entire cortical filament network extending 1-1.5 microm in depth from the membrane at the leading edge. The recruitment of the Arp2/3 complex at the membrane of the extending lamellipod indicates that Arp2/3 may be involved in initial generation of growing filaments. However, only a small subset of the complex present in the cortical network colocalizes near free barbed ends. This suggests that the 100-200-nm submembraneous compartment at the leading edge of the extending lamellipod constitutes a special biochemical microenvironment that favors the generation and maintenance of free barbed ends, possibly through the locally active Arp2/3 complex, severing or decreasing the on-rate of capping protein. Our results are inconsistent with the hypothesis suggesting uncapping is the dominant mechanism responsible for the generation of nucleation activity. However, they support the hypothesis of an Arp2/3-mediated capture of actin oligomers that formed close to the membrane by other mechanisms such as severing. They also support pointed-end capping by the Arp2/3 complex, accounting for its wide distribution at the leading edge.  (+info)

(4/259) The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.

Although small GTP-binding proteins of the Rho family have been implicated in signaling to the actin cytoskeleton, the exact nature of the linkage has remained obscure. We describe a novel mechanism that links one Rho family member, Cdc42, to actin polymerization. N-WASP, a ubiquitously expressed Cdc42-interacting protein, is required for Cdc42-stimulated actin polymerization in Xenopus egg extracts. The C terminus of N-WASP binds to the Arp2/3 complex and dramatically stimulates its ability to nucleate actin polymerization. Although full-length N-WASP is less effective, its activity can be greatly enhanced by Cdc42 and phosphatidylinositol (4,5) bisphosphate. Therefore, N-WASP and the Arp2/3 complex comprise a core mechanism that directly connects signal transduction pathways to the stimulation of actin polymerization.  (+info)

(5/259) Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerization in Acanthamoeba extracts.

BACKGROUND: Actin filaments polymerize in vivo primarily from their fast-growing barbed ends. In cells and extracts, GTPgammaS and Rho-family GTPases, including Cdc42, stimulate barbed-end actin polymerization; however, the mechanism responsible for the initiation of polymerization is unknown. There are three formal possibilities for how free barbed ends may be generated in response to cellular signals: uncapping of existing filaments; severing of existing filaments; or de novo nucleation. The Arp2/3 complex localizes to regions of dynamic actin polymerization, including the leading edges of motile cells and motile actin patches in yeast, and in vitro it nucleates the formation of actin filaments with free barbed ends. Here, we investigated actin polymerization in soluble extracts of Acanthamoeba. RESULTS: Addition of actin filaments with free barbed ends to Acanthamoeba extracts is sufficient to induce polymerization of endogenous actin. Addition of activated Cdc42 or activation of Rho-family GTPases in these extracts by the non-hydrolyzable GTP analog GTPgammaS stimulated barbed-end polymerization, whereas immunodepletion of Arp2 or sequestration of Arp2 using solution-binding antibodies blocked Rho-family GTPase-induced actin polymerization. CONCLUSIONS: For this system, we conclude that the accessibility of free barbed ends regulates actin polymerization, that Rho-family GTPases stimulate polymerization catalytically by de novo nucleation of free barbed ends and that the primary nucleation factor in this pathway is the Arp2/3 complex.  (+info)

(6/259) Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein.

The Arp2/3 complex is a highly conserved cytoskeletal component that has been implicated in the nucleation of actin filament assembly. Purified Arp2/3 complex has a low intrinsic actin nucleation activity, leading to the hypothesis that an unidentified cellular activator is required for the function of this complex. We showed previously that mutations in the Arp2/3 complex and in Bee1p/Las17p, a member of the Wiskott-Aldrich syndrome protein(WASP) family, lead to a loss of cortical actin structures (patches) in yeast. Bee1p has also been identified as an essential nucleation factor in the reconstitution of actin patches in vitro. Recently, it was reported that WASP-like proteins might interact directly with the Arp2/3 complex through a conserved carboxy-terminal domain. Here, we have shown that Bee1p and the Arp2/3 complex co-immunoprecipitate when expressed at endogenous levels, and that this interaction requires both the Arc15p and Arc19p subunits of the Arp2/3 complex. Furthermore, the carboxy-terminal domain of Bee1p greatly stimulated the nucleation activity of purified Arp2/3 complex in vitro, suggesting a direct role for WASP-family proteins in the activation of the Arp2/3 complex. Interestingly, deletion of the carboxy-terminal domain of Bee1p neither abolished the localization of the Arp2/3 complex, as had been suggested, nor resulted in a severe defect in cortical actin assembly. These results indicate that the function of Bee1p is not mediated entirely through its interaction with the Arp2/3 complex, and that factors redundant with Bee1p might exist to activate the nucleation activity of the Arp2/3 complex.  (+info)

(7/259) Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia.

The leading edge (approximately 1 microgram) of lamellipodia in Xenopus laevis keratocytes and fibroblasts was shown to have an extensively branched organization of actin filaments, which we term the dendritic brush. Pointed ends of individual filaments were located at Y-junctions, where the Arp2/3 complex was also localized, suggesting a role of the Arp2/3 complex in branch formation. Differential depolymerization experiments suggested that the Arp2/3 complex also provided protection of pointed ends from depolymerization. Actin depolymerizing factor (ADF)/cofilin was excluded from the distal 0.4 micrometer++ of the lamellipodial network of keratocytes and in fibroblasts it was located within the depolymerization-resistant zone. These results suggest that ADF/cofilin, per se, is not sufficient for actin brush depolymerization and a regulatory step is required. Our evidence supports a dendritic nucleation model (Mullins, R.D., J.A. Heuser, and T.D. Pollard. 1998. Proc. Natl. Acad. Sci. USA. 95:6181-6186) for lamellipodial protrusion, which involves treadmilling of a branched actin array instead of treadmilling of individual filaments. In this model, Arp2/3 complex and ADF/cofilin have antagonistic activities. Arp2/3 complex is responsible for integration of nascent actin filaments into the actin network at the cell front and stabilizing pointed ends from depolymerization, while ADF/cofilin promotes filament disassembly at the rear of the brush, presumably by pointed end depolymerization after dissociation of the Arp2/3 complex.  (+info)

(8/259) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits.

In previous work, we identified the yeast Arp2/3 complex, which localizes to cortical actin patches and is required for their motility and integrity in vivo. This complex contains proteins homologous to each subunit of the Acanthamoeba and human Arp2/3 complex except for a 40-kDa subunit (p40), which was missing from the purified yeast complex. Here, we demonstrate by using immunoprecipitation and gel-filtration analysis that Arc40p, the homolog of p40 identified from the yeast genome database, associates with the yeast Arp2/3 complex. We have carried out gene disruptions of each subunit of the yeast Arp2/3 complex to study each subunit's role in the function of the complex. Surprisingly, we find that only ARC40 is fully essential for cell viability. Strains lacking each of the other subunits exhibit varying degrees of defects in cell growth and viability and in assembly and polarization of cortical actin patches. We have also examined each subunit's role in maintaining the structural integrity of the Arp2/3 complex. Arp2p, Arp3p, and Arc40p fall into the monomer pool in Deltaarc19 and Deltaarc35 cells, suggesting that Arc19p and Arc35p are the central scaffolding components of the complex. Arp2p and Arp3p do not have major roles in maintaining complex integrity, and Arc15p is required for association of Arp2p and Arc40p, but not other subunits, with the complex. These results provide evidence that each subunit contributes differently to the assembly and function of the Arp2/3 complex.  (+info)

*  Actin related protein 2/3 complex inhibitor
... is a protein that in humans is encoded by the ARPIN gene. GRCh38: Ensembl release ... Actin related protein 2/3 complex inhibitor". Retrieved 2017-06-21. Deng WS, Zhang J, Ju H, Zheng HM, Wang J, Wang S, Zhang DL ...
*  ACTR3B
Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene. Pseudogenes of this ... This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid ... ACTR3B ARP3 actin-related protein 3 homolog B (yeast)". Human ACTR3B genome location and ACTR3B gene details page in the UCSC ... the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal ...
*  ACTR3
"The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches ... Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene. The specific function of this gene has not ... "Entrez Gene: ACTR3 ARP3 actin-related protein 3 homolog (yeast)". Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, ... Machesky LM, Insall RH (1999). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton ...
*  ARPC1A
Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene. This gene encodes one ... "Entrez Gene: ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa". Human ARPC1A genome location and ARPC1A gene details ... 1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of ... This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The ...
*  ARPC4
Actin-related protein 2/3 complex subunit 4 is a protein that in humans is encoded by the ARPC4 gene. This gene encodes one of ... "Entrez Gene: ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa". "Dysmorphology data for Arpc4". Wellcome Trust Sanger ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ...
*  ARPC3
Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene. This gene encodes one of ... "Entrez Gene: ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa". Welch MD, Iwamatsu A, Mitchison TJ (1997). "Actin ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... Marchand JB, Kaiser DA, Pollard TD, Higgs HN (2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 ...
*  ARPC2
Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene. This gene encodes one of ... "Entrez Gene: ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa". Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex". J ...
*  ARPC5
Actin-related protein 2/3 complex subunit 5 is a protein that in humans is encoded by the ARPC5 gene. This gene encodes one of ... "Entrez Gene: ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa". Millard TH, Behrendt B, Launay S, Fütterer K, Machesky ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/ ...
*  ARPC1B
Actin-related protein 2/3 complex subunit 1B is a protein that in humans is encoded by the ARPC1B gene. This gene encodes one ... "Entrez Gene: ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa". "Isoform diversity in the Arp2/3 complex determines ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The ...
*  List of MeSH codes (D12.776)
... actin-related protein 2 MeSH D12.776.220.525.246.750 - actin-related protein 3 MeSH D12.776.220.525.475.100 - myosin heavy ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
*  CDC42
"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... with actin-related protein (ARP2/3) complex". The Journal of Biological Chemistry. 275 (29): 21946-52. doi:10.1074/jbc. ... "Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP". Nature. 391 (6662): 93-6. doi:10.1038 ... Hart MJ, Callow MG, Souza B, Polakis P (June 1996). "IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a ...
*  HCLS1
2003). "Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin ... Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins ... Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins ... Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene. HCLS1 has been shown to ...
*  List of MeSH codes (D05)
... actin-related protein 2 MeSH D05.750.078.730.246.750 --- actin-related protein 3 MeSH D05.750.078.730.250 --- actins MeSH ... microfilament proteins MeSH D05.750.078.730.032 --- actin capping proteins MeSH D05.750.078.730.032.500 --- capz actin capping ... actin-related protein 2-3 complex MeSH D05.750.078.730.246.500 --- ... wiskott-aldrich syndrome protein family MeSH D05.750.078.730.912.500 --- wiskott-aldrich syndrome protein MeSH D05.750.078.730. ...
*  ACTR2
Actin-related protein 2 is a protein that in humans is encoded by the ACTR2 gene. The specific function of this gene has not ... "Entrez Gene: ACTR2 ARP2 actin-related protein 2 homolog (yeast)". Bearer EL, Prakash JM, Li Z (2002). "Actin dynamics in ... "The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches ... 1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of ...
*  WH2 motif
Machesky LM, Insall RH (1998). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton ... The WH2 domain binds to actin monomers and can facilitate the assembly of actin monomers into actin filaments. Human genes ... It is found in WASP proteins which control actin polymerisation, therefore, WH2 is important in cellular processes such as cell ... WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria. The WH2 domain is found as a ...
*  Chromosome 12 (human)
... encoding protein ADP-ribosylation-like factor 6 interacting protein 4 ARPC3: encoding protein Actin-related protein 2/3 complex ... encoding protein Protein asunder homolog (Asun) ATG101: Autophagy-related protein 101 BCAT1: encoding protein Branched chain ... encoding protein a protein of 377 amino acid residues FAM60A: encoding protein FAM60A FAM186B: encoding protein Protein FAM186B ... encoding protein Proline-rich protein HaeIII subfamily 2 PRR4: encoding protein Proline-rich protein 4 PTMS: encoding protein ...
*  WASL (gene)
... with actin-related protein (ARP2/3) complex". The Journal of Biological Chemistry. 275 (29): 21946-52. doi:10.1074/jbc. ... with actin-related protein (ARP2/3) complex". The Journal of Biological Chemistry. 275 (29): 21946-52. doi:10.1074/jbc. ... "Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP". Nature. 391 (6662): 93-6. doi:10.1038 ... Suzuki T, Miki H, Takenawa T, Sasakawa C (May 1998). "Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based ...
*  WASF1
Machesky LM, Insall RH (March 1999). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin ... Bear JE, Rawls JF, Saxe CL (1998). "SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late ... Marchand JB, Kaiser DA, Pollard TD, Higgs HN (2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 ... 2000). "Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold". EMBO J. 19 (17 ...
*  Rho family of GTPases
The actin formation required to close the wounds in young chicks is controlled by Rho GTPase proteins, since, after injection ... Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R (1989). "Rac, a novel ras-related family of proteins that are botulinum ... A second target to explain the role of the Rho proteins in cancer is their regulatory proteins. Rho proteins are very tightly ... G-actin) or filamentous (F-actin) forms. The role of Rho family of GTPases and its effects in the stability of actin and spine ...
*  WASF2
Machesky LM, Insall RH (1999). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton ... The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs ... Bear JE, Rawls JF, Saxe CL (1998). "SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late ... Wiskott-Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene. This gene encodes a ...
*  Actin assembly-inducing protein
NPFs in the mammalian cell recruit and bind to the already existing actin-related-protein 2 and 3 complex (Arp2/3 complex) and ... The Actin assembly-inducing protein (ActA) is a protein encoded and used by Listeria monocytogenes to propel itself through a ... an actin monomer binding protein, which itself promotes polymerization at barbed ends of actin filaments. Furthermore, VASP ... In the cytosol they start to polymerize actin on their surface by the help of the ActA protein. It has been shown that ActA is ...
*  CORO1B
Coronin, actin binding protein, 1B also known as CORO1B is a protein which in humans is encoded by the CORO1B gene. Members of ... Studies related to this protein are as follows: Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches ... Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (September 1998). "Definition of family of coronin-related proteins conserved ... "Entrez Gene: CORO1B coronin, actin binding protein, 1B". Cai L, Makhov AM, Schafer DA, Bear JE (September 2008). "Coronin 1B ...
*  SMARCD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a protein that in humans is ... The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase ... Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (July 1998). "Five SWI/SNF-related, matrix-associated, actin- ... "Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3". Puri ...
*  Chromosome 2 (human)
Partial list of the genes located on p-arm (short arm) of human chromosome 2: ACTR2: encoding protein Actin-related protein 2 ... encoding protein Transmembrane protein C2orf18 C2orf28: encoding protein Apoptosis-related protein 3 CAPG: capping acting ... Xin actin-binding repeat-containing protein 2 ZNF142: zinc finger protein 142 The following diseases and traits are related to ... encoding protein Erythrocyte membrane protein band 4.1 like 5 ERICH2: encoding protein Glutamate rich protein 2 FASTKD1: FAST ...
*  Microfilament
Filament end-tracking protein (e.g., formins, VASP, N-WASP) Filament-nucleator known as the Actin-Related Protein-2/3 (or Arp2/ ... Actin depolymerizing proteins such as ADF/cofilin. The actin filament network in non-muscle cells is highly dynamic. The actin ... These structures are regulated by many other classes of actin-binding proteins, including motor proteins, branching proteins, ... globular actin, or G-actin), which as part of the fiber are referred to as filamentous actin, or F-actin. Each microfilament is ...
*  BMF (gene)
... a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science ... Lei K, Davis RJ (2003). "JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis". Proc. ... The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as ... and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to ...
Actin-related protein 2/3 complex subunit 1B (IPR030141) | InterPro | EMBL-EBI  Actin-related protein 2/3 complex subunit 1B (IPR030141) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Actin-related protein 2/3 complex subunit 1 (IPR017383) *Actin-related protein 2/3 complex subunit 1B (IPR030141) ... Actin-related protein 2/3 complex subunit 1B (IPR030141). Short name: ARC1B ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR030141
Actin related protein 2/3 complex inhibitor - Wikipedia  Actin related protein 2/3 complex inhibitor - Wikipedia
Actin related protein 2/3 complex inhibitor is a protein that in humans is encoded by the ARPIN gene. GRCh38: Ensembl release ... Actin related protein 2/3 complex inhibitor". Retrieved 2017-06-21. Deng WS, Zhang J, Ju H, Zheng HM, Wang J, Wang S, Zhang DL ...
more infohttps://en.wikipedia.org/wiki/Actin_related_protein_2/3_complex_inhibitor
Arpc5l actin related protein 2/3 complex, subunit 5-like [Mus musculus (house mouse)] - Gene - NCBI  Arpc5l actin related protein 2/3 complex, subunit 5-like [Mus musculus (house mouse)] - Gene - NCBI
General protein information Go to the top of the page Help Preferred Names. actin-related protein 2/3 complex subunit 5-like ... mRNA and Protein(s) * XM_006498389.3 → XP_006498452.1 actin-related protein 2/3 complex subunit 5-like protein isoform X2 ... mRNA and Protein(s) * NM_028809.1 → NP_083085.1 actin-related protein 2/3 complex subunit 5-like protein ... actin related protein 2/3 complex, subunit 5-likeprovided by MGI. Primary source. MGI:MGI:1921442 See related. Ensembl: ...
more infohttps://www.ncbi.nlm.nih.gov/gene/?term=74192
actin related protein 2/3 complex subunit 5-like ELISA Kits | Biocompare.com  actin related protein 2/3 complex subunit 5-like ELISA Kits | Biocompare.com
Compare actin related protein 2/3 complex subunit 5-like ELISA Kits from leading suppliers on Biocompare. View specifications, ... actin related protein 2/3 complex subunit 5-like ELISA Kits. Clear ... actin related protein 2/3 complex subunit 5-like ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well- ... Bovine Actin-related protein 2/3 complex subunit 5-like protein (ARPC5L) ELISA Kit ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-2273513/ELISA_Kit/ELISA_actin_related_protein_23_complex_subunit_5-like
Arpc4 - Actin-related protein 2/3 complex subunit 4 - Mus musculus (Mouse) - Arpc4 gene & protein  Arpc4 - Actin-related protein 2/3 complex subunit 4 - Mus musculus (Mouse) - Arpc4 gene & protein
... repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks ( ... a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 ... complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition ... the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of ...
more infohttps://www.uniprot.org/uniprot/P59999
Arpc2 - Actin-related protein 2/3 complex subunit 2 - Rattus norvegicus (Rat) - Arpc2 gene & protein  Arpc2 - Actin-related protein 2/3 complex subunit 2 - Rattus norvegicus (Rat) - Arpc2 gene & protein
... mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). ... Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together ... Actin-related protein 2/3 complex subunit 2Add BLAST. 300. Amino acid modifications. Feature key. Position(s). Description ... Actin-related protein 2/3 complex subunit 2By similarity. ,p>Manually curated information which has been propagated from a ...
more infohttp://www.uniprot.org/uniprot/P85970
actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114): Novus Biologicals  actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114): Novus Biologicals
Rabbit Polyclonal Anti-actin-related protein 2/3 complex subunit 1B Antibody. Validated: WB, IHC, IHC-P. Tested Reactivity: ... Discover related pathways, diseases and genes to actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114). Need help ... Discover more about diseases related to actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114). ... Learn more about PTMs related to actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114). ...
more infohttps://www.novusbio.com/products/actin-related-protein-2-3-complex-subunit-1b-antibody_nbp1-90114
LOC686150 (similar to actin related protein 2/3 complex, subunit 5) - Rat Genome Database  LOC686150 (similar to actin related protein 2/3 complex, subunit 5) - Rat Genome Database
similar to actin related protein 2/3 complex, subunit 5 Symbol and Name status set to provisional. 70820. PROVISIONAL. ... Gene: LOC686150 (similar to actin related protein 2/3 complex, subunit 5) Rattus norvegicus. {{ watchLinkText }} ... Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer ( ... Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & ...
more infohttps://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1585449
ARPC1A (actin related protein 2/3 complex, subunit 1A) - KOMP (Knockout Mouse Project)  ARPC1A (actin related protein 2/3 complex, subunit 1A) - KOMP (Knockout Mouse Project)
OMIM: ACTIN-RELATED PROTEIN 2/3 COMPLEX, SUBUNIT 1A; ARPC1A*Gene Ontology: Arpc1a *Mouse Phenome DB: Arpc1a *UCSC: Chr.5: ... actin related protein 2/3 complex, subunit 1A. Synonyms: 0610010H08Rik, 1110030K07Rik, Sid32. Gene nomenclature, locus ...
more infohttps://www.komp.org/geneinfo.php?geneid=23773
Actin related protein 2/3 complex, subunit 5 | definition of actin related protein 2/3 complex, subunit 5 by Medical dictionary  Actin related protein 2/3 complex, subunit 5 | definition of actin related protein 2/3 complex, subunit 5 by Medical dictionary
What is actin related protein 2/3 complex, subunit 5? Meaning of actin related protein 2/3 complex, subunit 5 medical term. ... What does actin related protein 2/3 complex, subunit 5 mean? ... Looking for online definition of actin related protein 2/3 ... complex, subunit 5 in the Medical Dictionary? actin related protein 2/3 complex, subunit 5 explanation free. ... redirected from actin related protein 2/3 complex, subunit 5) ARPC5. A gene on chromosome 1q25.3 that encodes p16, one of the ...
more infohttp://medical-dictionary.thefreedictionary.com/actin+related+protein+2%2F3+complex%2C+subunit+5
ARPC5, Recombinant, Human, aa1-151, His-tag (Actin-related Protein 2/3 Complex Subunit 5 Protein, A | Proteins | Proteins and...  ARPC5, Recombinant, Human, aa1-151, His-tag (Actin-related Protein 2/3 Complex Subunit 5 Protein, A | Proteins | Proteins and...
... mediates the formation of branched actin networks. [The UniProt Consortium] ... Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an ... ARPC5, Recombinant, Human, aa1-151, His-tag (Actin-related Protein 2/3 Complex Subunit 5 Protein, A ... Customer review for "ARPC5, Recombinant, Human, aa1-151, His-tag (Actin-related Protein 2/3 Complex Subunit 5 Protein, A" ...
more infohttps://www.biomol.com/products/proteins-and-peptides/proteins/arpc5-recombinant-human-aa1-151-his-tag-actin-related-protein-2/3-complex-subunit-5-protein-a-a0760-89c.100
Actin-Related Protein 3 (Arp3) | The Actin-Related Protein 2/3 Complex  Actin-Related Protein 3 (Arp3) | The Actin-Related Protein 2/3 Complex
... which consists of 20 proteins from different species. It is a subunit of ARP2/3 complex, along with Arp 2 and other 5 subunits ... www.ncbi.nlm.nih.gov/protein/5031573 Family: Arp 3 belongs to actin family and Arp 3 subfamily, ... Actin-Related Protein 3 (Arp3) [Homo Sapiens] P: 61168: http:// ... Actin-Related Protein 2 (Arp2). *Actin-Related Protein 3 (Arp3) ... The Actin-Related Protein 2/3 Complex. Molecular Exploration Project - The Principles of Cellular Control (CELL2007) ...
more infohttps://arp23.wordpress.com/fasta/actin-related-protein-3-arp3/
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex | PNAS  Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex | PNAS
... a stable assembly of two actin-related proteins (Arp2 and Arp3) with five other subunits, caps the pointed end of actin ... This stable and abundant complex of two actin-related proteins (Arp2 and Arp3) with five other polypeptides nucleates actin ... Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Laura M. Machesky, R. Dyche ... We conclude that Scar and, likely, related proteins like WASp are endogenous activators of de novo actin filament assembly. ...
more infohttps://www.pnas.org/content/96/7/3739?ijkey=ca9065027a106fd75239ca72610aeada6d845167&keytype2=tf_ipsecsha
Introduction | The Actin-Related Protein 2/3 Complex  Introduction | The Actin-Related Protein 2/3 Complex
... an actin monomer, a mother filament and a nucleation promoting-factor needed to activate the complex which is intrinsically ... Introduction The Arp2/3 complex is responsible for nucleation of actin filaments to form branches at a distinct 70 degrees ... Several factors are known to interact with the Arp2/3 complex, most… ... The Actin-Related Protein 2/3 Complex. Molecular Exploration Project - The Principles of Cellular Control (CELL2007) ...
more infohttps://arp23.wordpress.com/molecular-renderings/1-introduction/
Actin-related protein 2/3 complex subunit 1B  Actin-related protein 2/3 complex subunit 1B
HCA RNA Cell Line for Actin-related protein 2/3 complex subunit 1B. ... Compartment GO Terms for Actin-related protein 2/3 complex subunit 1B. ... This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The ... This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided ...
more infohttps://pharos.nih.gov/idg/targets/ARPC1B
Arpc3 - actin related protein 2/3 complex, subunit 3 | International Mouse Phenotyping Consortium  Arpc3 - actin related protein 2/3 complex, subunit 3 | International Mouse Phenotyping Consortium
Get highlights of the most important data releases, news and events, delivered straight to your email inbox. Subscribe to newsletter ...
more infohttps://www.wwww.mousephenotype.org/data/genes/MGI:1928375
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse....  Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse....
... the actin-nucleating formins, Diaphanous-1 (DIA1) and Formin-like-1 (FMNL1), did not affect TCR-stimulated F-actin-rich ... and formin-dependent F-actin nucleation during T cell activation. We demonstrated that without Arp2/3-mediated actin nucleation ... stimulated T cells could not form an F-actin-rich lamellipod, but instead produced polarized filopodia-like structures. ... Altogether, our results have identified Arp2/3 complex-independent cytoskeletal reorganization events in T lymphocytes and ...
more infohttps://www.semanticscholar.org/paper/Formins-regulate-the-actin-related-protein-2-3-com-Gomez-Kumar/af4e042e4f245c878d26e7bdf16548eddfae0931
Add your annotation to InterPro | InterPro | EMBL-EBI  Add your annotation to InterPro | InterPro | EMBL-EBI
Actin-related protein 2/3 complex subunit 3 superfamily (IPR036753). Add your Annotation. Your annotation. You may suggest ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR036753/add-annotation
Category:Proteins - Wikimedia Commons  Category:Proteins - Wikimedia Commons
Protein abundance‎ (15 В). *. ► Actin-related protein 3‎ (10 В). *. ► Protein aggregation‎ (2 В) ... Protein (lb); protein (nb); Protéin (su); Protein (hif); 朊 (lzh); بروتين (ar); Protein (br); ပရိုတိန်း (my); 蛋白質 (yue); Белок ( ... प्रोटिन (dty); Prótín (is); Protein (ms); protein (tr); لحمیات (ur); Bielkovina (sk); білок (uk); 蛋白质 (zh-cn); Protein (gsw); ... protein (sco); Уураг (mn); protein (nn); ಪ್ರೋಟೀನ್ (kn); پرۆتین (ckb); protein (en); fehérje (hu); પ્રોટિન (gu); प्रोटिन (new); ...
more infohttps://commons.wikimedia.org/wiki/Category:Proteins?uselang=be
  • 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. (nih.gov)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • The growth of this network drives protrusion of the membrane, probably by a Brownian ratchet-type mechanism ( 3 , 4 ). (pnas.org)
  • Your search returned 43822 (a)3 ELISA ELISA Kit across 69 suppliers. (biocompare.com)
  • In no case is the pathway from receptor to newly formed actin filaments established, and the situation is complicated by the branching of signals into multiple pathways downstream of both seven-helix G protein-coupled receptors and receptor tyrosine kinases. (pnas.org)
  • Endocytosis, organism-specific biosystem Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. (nih.gov)
  • A host of protein factors control membrane traffic through the interconnected tubules and vesicles of the endosomal system, and sorting occurs by isolation of cargo in membrane domains of defined geometry and lipid composition ( Bonifacino and Rojas, 2006 ). (rupress.org)
  • Proteins modulating membrane dynamics and organization are thus well positioned to control the sorting and activities of signaling complexes during endosomal processing. (rupress.org)
  • Nwk (Nervous Wreck) is a presynaptic F-BAR/SH3 protein that regulates synaptic growth signaling in Drosophila melanogaster . (rupress.org)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • Therefore, defining the mechanisms by which the rate and direction of the flow of endosomal protein traffic are controlled is critical to determining how neuronal signal transduction pathways are tuned up and down after activation. (rupress.org)
  • Publications] K.Nakano: 'Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton'Molecular Biology of the Cell. (nii.ac.jp)
  • SNX16 promotes synaptic growth signaling by activated bone morphogenic protein receptors, and live imaging in neurons reveals that SNX16-positive early endosomes undergo transient interactions with Nwk-containing recycling endosomes. (rupress.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. (uniprot.org)
  • This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. (nih.gov)
  • Arp 3 belongs to actin family and Arp 3 subfamily, which consists of 20 proteins from different species. (wordpress.com)
  • In the present study, we sequenced the transcriptomes of two closely related primrose species, Primula poissonii and Primula wilsonii, using short reads on the Illumina Genome Analyzer platform. (biomedcentral.com)
  • 0.5), and functional enrichment analysis revealed that significant proportions of the orthologs were in the categories DNA repair, stress resistance, which may provide some hints as to how the two closely related Primula species adapted differentially to extreme environments, such as habitats characterized by aridity, high altitude and high levels of ionizing radiation. (biomedcentral.com)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. (phosphosite.org)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)