Actin-Related Protein 3: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.Actin-Related Protein 2: A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Actin-Related Protein 2-3 Complex: A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Vitamin K Epoxide Reductases: OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.Mediator Complex: A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Actin-Related Protein 3: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.Actin-Related Protein 2: A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.Actin-Related Protein 2-3 Complex: A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.Vitamin K Epoxide Reductases: OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.Mediator Complex: A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Miller Fisher Syndrome: A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Actin Cytoskeleton: Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.Actin Depolymerizing Factors: A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. They remodel the actin CYTOSKELETON by severing ACTIN FILAMENTS and increasing the rate of monomer dissociation.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Actin-Related Protein 3: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.Actin-Related Protein 2: A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.Actin-Related Protein 2-3 Complex: A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Actin Cytoskeleton: Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.Microfilament Proteins: Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.CapZ Actin Capping Protein: An actin capping protein that binds to the barbed-ends of ACTIN filaments. It is a heterodimer consisting of an alpha and a beta subunit. It regulates actin assembly by stabilizing actin oligomers for elongation. In SKELETAL MUSCLE, CapZ is localized to the Z-disk.Barbering: The occupation concerned with the cutting and dressing of the hair of customers and, of men, the shaving and trimming of the beard and mustache. (From Random House Unabridged Dictionary, 2d ed)Profilins: A family of low molecular weight proteins that bind ACTIN and control actin polymerization. They are found in eukaryotes and are ubiquitously expressed.Cytoskeleton: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.Actin-Related Protein 2-3 Complex: A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.Actin-Related Protein 3: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.Actin-Related Protein 2: A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Actin Cytoskeleton: Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.Microfilament Proteins: Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.Equipment Design: Methods of creating machines and devices.Wiskott-Aldrich Syndrome Protein, Neuronal: A member of the Wiskott-Aldrich syndrome protein family that is found at high levels in NERVE CELLS. It interacts with GRB2 ADAPTOR PROTEIN and with CDC42 PROTEIN.Cytoskeletal Proteins: Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.Cytoskeleton: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.Centrosome: The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).Actin-Related Protein 3: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.Actin-Related Protein 2: A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.Immunological Synapses: The interfaces between T-CELLS and ANTIGEN-PRESENTING CELLS. Supramolecular organization of proteins takes place at these synapses involving various types of immune cells. Immunological synapses can have several functions including LYMPHOCYTE ACTIVATION; enhancing, balancing, or terminating signaling; or directing cytokine secretion.Microtubule-Organizing Center: An amorphous region of electron dense material in the cytoplasm from which the MICROTUBULES polymerization is nucleated. The pericentriolar region of the CENTROSOME which surrounds the CENTRIOLES is an example.Actin-Related Protein 2-3 Complex: A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Microfilament Proteins: Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.Pseudopodia: A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.Cytoskeleton: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Actin-Related Protein 2-3 Complex: A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.Actin-Related Protein 2: A PROFILIN binding domain protein that is part of the Arp2-3 complex. It is related in sequence and structure to ACTIN and binds ATP.Actin-Related Protein 3: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.Microfilament Proteins: Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.Actin Cytoskeleton: Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.Wiskott-Aldrich Syndrome Protein, Neuronal: A member of the Wiskott-Aldrich syndrome protein family that is found at high levels in NERVE CELLS. It interacts with GRB2 ADAPTOR PROTEIN and with CDC42 PROTEIN.Seminiferous Epithelium: The epithelium lining the seminiferous tubules composed of primary male germ cells (SPERMATOGONIA) and supporting SERTOLI CELLS. As SPERMATOGENESIS proceeds, the developing germ cells migrate toward the lumen. The adluminal compartment, the inner two thirds of the tubules, contains SPERMATOCYTES and the more advanced germ cells.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Repetitive Sequences, Amino Acid: A sequential pattern of amino acids occurring more than once in the same protein sequence.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Shadowing (Histology): The technique of spraying a tissue specimen with a thin coat of a heavy metal such as platinum. The specimen is sprayed from an oblique angle, which results in the uneven deposition of the coating. The varying thicknesses create a shadow effect and give a three-dimensional appearance to the specimen.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Ankyrin Repeat: Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating sequence of 33-amino acids was discovered in ANKYRIN where it is involved in interaction with the anion exchanger (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE). Ankyrin repeats cooperatively fold into domains that mediate molecular recognition via protein-protein interactions.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.ArchivesInternet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Radiology Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.
(1/347) Arabidopsis contains ancient classes of differentially expressed actin-related protein genes.

Actin-related proteins (ARPs) share less than 60% amino acid sequence homology with conventional actins and have roles in diverse cytoskeletal processes in the cytoplasm and nucleus. The genome of Arabidopsis was explored for possible ARP gene family members. Eight potential ARP gene sequences were found dispersed on three of the five Arabidopsis chromosomes. AtARP2 and AtARP3 are protein orthologs of their similarly named counterparts in other kingdoms. AtARP4, AtARP5, and AtARP6 are orthologs of two classes of nuclear ARPs previously characterized in animals and fungi, BAF53s and ARP6s. AtARP7 and AtARP8 appear to be novel proteins that are not closely related to any known animal or fungal ARPs, and may be plant specific. The complex Arabidopsis ARP gene structures each contain from five to 20 exons. Expressed transcripts were identified and characterized for AtARP2 through AtARP8, but not for AtARP9, and transcripts representing two splice variants were found for AtARP8. The seven expressed genes are predicted to encode proteins ranging from 146 to 471 amino acids in length. Relative to conventional actin and the other ARPs, AtARP2 and AtARP3 transcripts are expressed at very low levels in all organs. AtARP5, AtARP6, and AtARP8 each have distinct transcript expression patterns in seedlings, roots, leaves, flowers, and siliques. Using isovariant-specific monoclonal antibodies, AtARP4 and AtARP7 proteins were shown to be most highly expressed in flowers. The likely involvement of plant ARPs in actin nucleation, branching of actin filaments, chromatin restructuring, and transcription are briefly discussed.  (+info)

(2/347) Arabidopsis CROOKED encodes for the smallest subunit of the ARP2/3 complex and controls cell shape by region specific fine F-actin formation.

The generation of a specific cell shape requires differential growth, whereby specific regions of the cell expand more relative to others. The Arabidopsis crooked mutant exhibits aberrant cell shapes that develop because of mis-directed expansion, especially during a rapid growth phase. GFP-aided visualization of the F-actin cytoskeleton and the behavior of subcellular organelles in different cell-types in crooked and wild-type Arabidopsis revealed that localized expansion is promoted in cellular regions with fine F-actin arrays but is restricted in areas that maintain dense F-actin. This suggested that a spatiotemporal distinction between fine versus dense F-actin in a growing cell could determine the final shape of the cell. CROOKED was molecularly identified as the plant homolog of ARPC5, the smallest sub-unit of the ARP2/3 complex that in other organisms is renowned for its role in creating dendritic arrays of fine F-actin. Rescue of crooked phenotype by the human ortholog provides the first molecular evidence for the presence and functional conservation of the complex in higher plants. Our cell-biological and molecular characterization of CROOKED suggests a general actin-based mechanism for regulating differential growth and generating cell shape diversity.  (+info)

(3/347) Mutations in actin-related proteins 2 and 3 affect cell shape development in Arabidopsis.

ACTIN-RELATED PROTEINS 2 and 3 form the major subunits of the ARP2/3 complex, which is known as an important regulator of actin organization in diverse organisms. Here, we report that two genes, WURM and DISTORTED1, which are important for cell shape control in Arabidopsis, encode the plant ARP2 and ARP3 orthologs, respectively. Mutations in these genes result in misdirected expansion of various cell types: trichome expansion is randomized, pavement cells fail to produce lobes, hypocotyl cells curl out of the normal epidermal plane, and root hairs are sinuous. At the subcellular level, cell shape changes are linked to severe filamentous actin aggregation and compromised vacuole fusion. Because all seven subunits of the ARP2/3 complex are present in plants, our data indicate that this complex may play a pivotal role during plant cell morphogenesis.  (+info)

(4/347) Requirements for Arabidopsis ATARP2 and ATARP3 during epidermal development.

Plant cells employ the actin cytoskeleton to stably position organelles, as tracks for long distance transport, and to reorganize the cytoplasm in response to developmental and environmental cues. While diverse classes of actin binding proteins have been implicated in growth control, the mechanisms of cytoskeletal reorganization and the cellular functions of specific actin filament arrays are unclear. Arabidopsis trichome morphogenesis includes distinct requirements for the microtubule and actin filament cytoskeletons. It also is a genetically tractable process that is providing new knowledge about cytoskeleton function in plants. The "distorted group" of mutants defines a class of at least eight genes that are required during the actin-dependent phase of trichome growth. Using map-based cloning and a candidate gene approach, we identified mutations in ARP3 (ATARP3) and ARP2 (ATARP2) genes as the cause of the distorted1 (dis1) and wurm (wrm) phenotypes, respectively. ARP2 and ARP3 are components of the evolutionarily conserved ARP2/3 complex that nucleates actin filament polymerization [3]. Mutations in DIS1 and WRM caused severe trichome growth defects but had relatively mild effects on shoot development. DIS1 rescued the phenotype of Deltaarp3 when overexpressed in S. cerevisiae. Developing dis1 trichomes had defects in cytoplasmic actin bundle organization and reduced relative amounts of cytoplasmic actin filaments in developing branches.  (+info)

(5/347) The putative Arabidopsis arp2/3 complex controls leaf cell morphogenesis.

The evolutionarily conserved Arp2/3 complex has been shown to activate actin nucleation and branching in several eukaryotes, but its biological functions are not well understood in multicellular organisms. The model plant Arabidopsis provides many advantages for genetic dissection of the function of this conserved actin-nucleating machinery, yet the existence of this complex in plants has not been determined. We have identified Arabidopsis genes encoding homologs of all of the seven Arp2/3 subunits. The function of the putative Arabidopsis Arp2/3 complex has been studied using four homozygous T-DNA insertion mutants for ARP2, ARP3, and ARPC5/p16. All four mutants display identical defects in the development of jigsaw-shaped epidermal pavement cells and branched trichomes in the leaf. These loss-of-function mutations cause mislocalization of diffuse cortical F-actin to the neck region and inhibit lobe extension in pavement cells. The mutant trichomes resemble those treated with the actin-depolymerizing drug cytochalasin D, exhibiting stunted branches but dramatically enlarged stalks due to depolarized growth suggesting defects in the formation of a fine actin network. Our data demonstrate that the putative Arabidopsis Arp2/3 complex controls cell morphogenesis through its roles in cell polarity establishment and polar cell expansion. Furthermore, our data suggest a novel function for the putative Arp2/3 complex in the modulation of the spatial distribution of cortical F-actin and provide evidence that the putative Arp2/3 complex may activate the polymerization of some types of actin filaments in specific cell types.  (+info)

(6/347) p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.

The formation of new branched actin filament networks at the cell cortex of migrating cells is choreographed by the actin-related protein (Arp) 2/3 complex. Despite the fundamental role of the Arp2/3 complex in actin nucleation and branching, upstream signals that control the functions of p41-Arc, a putative regulatory component of the mammalian Arp2/3 complex, remain unidentified. Here we show that p41-Arc interacts with p21-activated kinase 1 (Pak1) both in vitro and in vivo. Pak1 phosphorylation of p41-Arc regulates its localization with the Arp2/3 complex in the cortical nucleation regions of cells. Pak1 phosphorylates p41-Arc on threonine 21 in the first WD repeat, and its mutation has functional implications in vivo. Threonine 21 phosphorylation by Pak1 is required for both constitutive and growth-factor-induced cell motility. Pak1 regulation of p41-Arc activation status represents a novel mechanism by which signalling pathways may influence the functions of the Arp2/3 complex, leading to motility in mammalian cells.  (+info)

(7/347) Arabidopsis GNARLED encodes a NAP125 homolog that positively regulates ARP2/3.

In migrating cells, the actin filament nucleation activity of ARP2/3 is an essential component of dynamic cell shape change and motility. In response to signals from the small GTPase Rac1, alterations in the composition and/or subcellular localization of the WAVE complex lead to ARP2/3 activation. The human WAVE complex subunit, WAVE1/SCAR1, was first identified in Dictyostelium and is a direct ARP2/3 activator. In the absence of an intact WAVE complex, SCAR/WAVE protein is destabilized. Although the composition of the five-subunit WAVE complex is well characterized, the means by which individual subunits and fully assembled WAVE complexes regulate ARP2/3 in vivo are unclear. The molecular genetics of trichome distortion in Arabidopsis is a powerful system to understand how signaling pathways and ARP2/3 control multicellular development. In this paper we prove that the GNARLED gene encodes a homolog of the WAVE subunit NAP125. Despite the moderate level of amino acid identity between Arabidopsis and human NAP125, both homologs were functionally interchangeable in vivo and interacted physically with the putative Arabidopsis WAVE subunit ATSRA1. gnarled trichomes had nearly identical cell shape and actin cytoskeleton phenotypes when compared to ARP2/3 subunit mutants, suggesting that GRL positively regulates ARP2/3.  (+info)

(8/347) Arabidopsis NAP1 is essential for Arp2/3-dependent trichome morphogenesis.

The dynamic nature of the eukaryotic actin cytoskeleton is essential for the locomotion of animal cells and the morphogenesis of plant and fungal cells. The F-actin nucleating/branching activity of the Arp2/3 complex is a key function for all of these processes. The SCAR/WAVE family represents a group of Arp2/3 activators that are associated with lamellipodia formation. A protein complex of PIR121, NAP1, ABI, and HSPC300 is required for SCAR regulation by cell signaling pathways, but the exact nature of this interaction is controversial and represents a continually evolving model. The mechanism originally proposed was of a SCAR trans repressing complex supported by evidence from in vitro experiments. This model was reinforced by genetic studies in the Drosophila central nervous system and Dictyostelium, where the knockout of certain SCAR-complex components leads to excessive SCAR-mediated actin polymerization. Conflicting data have steadily accumulated from animal tissue culture experiments suggesting that the complex activates rather than represses in vivo SCAR activity. Recent biochemical evidence supports the SCAR-complex activator model. Here, we show that genetic observations in Arabidopsis are compatible with an activation model and provide one potential mechanism for the regulation of the newly identified Arabidopsis Arp2/3 complex.  (+info)

*  Actin related protein 2/3 complex inhibitor
... is a protein that in humans is encoded by the ARPIN gene. GRCh38: Ensembl release ... Actin related protein 2/3 complex inhibitor". Retrieved 2017-06-21. Deng WS, Zhang J, Ju H, Zheng HM, Wang J, Wang S, Zhang DL ...
*  ARPC1A
Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene. This gene encodes one ... Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. ... "Entrez Gene: ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa". Human ARPC1A genome location and ARPC1A gene details ... 1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of ...
*  ARPC4
Actin-related protein 2/3 complex subunit 4 is a protein that in humans is encoded by the ARPC4 gene. This gene encodes one of ... "Entrez Gene: ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa". "Dysmorphology data for Arpc4". Wellcome Trust Sanger ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ...
*  ARPC3
Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene. This gene encodes one of ... "Entrez Gene: ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa". Welch MD, Iwamatsu A, Mitchison TJ (1997). "Actin ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... Marchand JB, Kaiser DA, Pollard TD, Higgs HN (2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 ...
*  ARPC2
Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene. This gene encodes one of ... "Entrez Gene: ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa". Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex". J ...
*  ARPC5
Actin-related protein 2/3 complex subunit 5 is a protein that in humans is encoded by the ARPC5 gene. This gene encodes one of ... "Entrez Gene: ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa". Millard TH, Behrendt B, Launay S, Fütterer K, Machesky ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/ ...
*  ARPC1B
Actin-related protein 2/3 complex subunit 1B is a protein that in humans is encoded by the ARPC1B gene. This gene encodes one ... Isoforms of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Indeed it ... "Entrez Gene: ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa". "Isoform diversity in the Arp2/3 complex determines ... "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily ...
*  ACTR2
"The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches ... Actin-related protein 2 is a protein that in humans is encoded by the ACTR2 gene. The specific function of this gene has not ... 1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of ... "Entrez Gene: ACTR2 ARP2 actin-related protein 2 homolog (yeast)". Bearer EL, Prakash JM, Li Z (2002). "Actin dynamics in ...
*  ACTR3
"The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches ... Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene. The specific function of this gene has not ... "Entrez Gene: ACTR3 ARP3 actin-related protein 3 homolog (yeast)". Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, ... Machesky LM, Insall RH (1999). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton ...
*  Chromosome 12 (human)
... encoding protein ADP-ribosylation-like factor 6 interacting protein 4 ARPC3: encoding protein Actin-related protein 2/3 complex ... encoding protein Intermediate filament family orphan 1 KANSL2: encoding protein KAT8 regulatory NSL complex subunit 2 (KANSL2) ... encoding protein Protein asunder homolog (Asun) ATG101: Autophagy-related protein 101 BCAT1: encoding protein Branched chain ... encoding protein a protein of 377 amino acid residues FAM60A: encoding protein FAM60A FAM186B: encoding protein Protein FAM186B ...
*  List of MeSH codes (D05)
... actin-related protein 2-3 complex MeSH D05.750.078.730.246.500 --- actin-related protein 2 MeSH D05.750.078.730.246.750 --- ... photosystem i protein complex MeSH D05.500.562.496 --- photosystem ii protein complex MeSH D05.500.562.500 --- proteasome ... microfilament proteins MeSH D05.750.078.730.032 --- actin capping proteins MeSH D05.750.078.730.032.500 --- capz actin capping ... actin-related protein 3 MeSH D05.750.078.730.250 --- actins MeSH D05.750.078.730.281 --- cortactin MeSH D05.750.078.730.350 ...
*  HCLS1
2003). "Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin ... Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins ... Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins ... Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene. HCLS1 has been shown to ...
*  Actin assembly-inducing protein
NPFs in the mammalian cell recruit and bind to the already existing actin-related-protein 2 and 3 complex (Arp2/3 complex) and ... The Actin assembly-inducing protein (ActA) is a protein encoded and used by Listeria monocytogenes to propel itself through a ... an actin monomer binding protein, which itself promotes polymerization at barbed ends of actin filaments. Furthermore, VASP ... In the cytosol they start to polymerize actin on their surface by the help of the ActA protein. It has been shown that ActA is ...
*  List of A1 genes, proteins or receptors
Actin, alpha 1 Actinin, alpha 1 Adaptor-related protein complex 2, alpha 1 Aldehyde dehydrogenase 3 family, member A1 Aldehyde ... mitochondrial F1 complex, alpha 1 BCL2-related protein A1 Butyrophilin, subfamily 1, member A1 Butyrophilin, subfamily 3, ... DP alpha 1 Major histocompatibility complex, class II, DQ alpha 1 Myosin light chain A1, an actin-binding protein NADH ... alpha 1 RNA binding motif protein, Y-linked, family 1, member A1 Replication protein A1 S100 calcium binding protein A1 Sec61 ...
*  Microfilament
Filament end-tracking protein (e.g., formins, VASP, N-WASP) Filament-nucleator known as the Actin-Related Protein-2/3 (or Arp2/ ... complex Filament cross-linkers (e.g., α-actinin, fascin, and fimbrin) Actin monomer-binding proteins profilin and thymosin β4 ... Actin depolymerizing proteins such as ADF/cofilin. The actin filament network in non-muscle cells is highly dynamic. The actin ... These structures are regulated by many other classes of actin-binding proteins, including motor proteins, branching proteins, ...
*  ACTL6A
... expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex ... Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene. This gene encodes a family member of actin- ... related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have ... "Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein ...
*  WH2 motif
Machesky LM, Insall RH (1998). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton ... The WH2 domain binds to actin monomers and can facilitate the assembly of actin monomers into actin filaments. Human genes ... It is found in WASP proteins which control actin polymerisation, therefore, WH2 is important in cellular processes such as cell ... WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria. The WH2 domain is found as a ...
*  ACTR3B
This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid ... Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene. Pseudogenes of this ... ACTR3B ARP3 actin-related protein 3 homolog B (yeast)". Human ACTR3B genome location and ACTR3B gene details page in the UCSC ... the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal ...
*  CCT3
The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different ... "cDNA encoding a novel TCP1-related protein". Biochimica et Biophysica Acta. 1217 (2): 224-6. doi:10.1016/0167-4781(94)90041-8. ... T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene. This gene encodes a molecular ... Yuryev A, Wennogle LP (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid ...
*  Metabotropic glutamate receptor 5
Enz R (March 2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS ... "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, ... "Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface ... Metabotropic glutamate receptor 5 is a G protein-coupled receptor that in humans is encoded by the GRM5 gene. The amino acid L- ...
*  Actin-binding protein
ActA Actibind Actin Actinfilin Actinogelin Actin-regulating kinases Actin-Related Proteins Actobindin Actolinkin Actopaxin ... Actin-binding proteins (also known as ABP) are proteins that bind to actin. This may mean ability to bind actin monomers, or ... Many actin-binding proteins, including α-actinin, β-spectrin, dystrophin, utrophin and fimbrin, do this through the actin- ... related to the ERM proteins) Myosins MAP-1C Metavinculin Moesin (the M of ERM proteins) Myosin light chain kinase MAL Mip-90 ...
*  CORO1B
Coronin, actin binding protein, 1B also known as CORO1B is a protein which in humans is encoded by the CORO1B gene. Members of ... Studies related to this protein are as follows: Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches ... Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (September 1998). "Definition of family of coronin-related proteins conserved ... "Entrez Gene: CORO1B coronin, actin binding protein, 1B". Cai L, Makhov AM, Schafer DA, Bear JE (September 2008). "Coronin 1B ...
*  Mechanistic target of rapamycin
mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR ... mTOR signaling appears to be closely related to the presence of soluble amyloid beta (Aβ) and tau proteins, which aggregate and ... mTORC2 has been shown to function as an important regulator of the actin cytoskeleton through its stimulation of F-actin stress ... This complex functions as a nutrient/energy/redox sensor and controls protein synthesis. The activity of mTORC1 is regulated by ...
*  Vinculin family
Alpha-catenins are proteins of about 100 kDa which are evolutionary related to vinculin. In terms of their structure the most ... The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to ... In addition to actin, vinculin interacts with other structural proteins such as talin and alpha-actinins. Vinculin is a large ... Vinculin is a eukaryotic protein that seems to be involved in the attachment of the actin-based microfilaments to the plasma ...
*  DCTN2
"Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end". J. ... "The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain". ... This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to ... Yue L, Lu S, Garces J, Jin T, Li J (2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice ...
*  BMF (gene)
... a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science ... Lei K, Davis RJ (2003). "JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis". Proc. ... The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as ... and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to ...
Actin-related protein 2/3 complex subunit 1B (IPR030141) | InterPro | EMBL-EBI  Actin-related protein 2/3 complex subunit 1B (IPR030141) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Actin-related protein 2/3 complex subunit 1 (IPR017383) *Actin-related protein 2/3 complex subunit 1B (IPR030141) ... Actin-related protein 2/3 complex subunit 1B (IPR030141). Short name: ARC1B ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR030141
Actin related protein 2/3 complex inhibitor - Wikipedia  Actin related protein 2/3 complex inhibitor - Wikipedia
Actin related protein 2/3 complex inhibitor is a protein that in humans is encoded by the ARPIN gene. GRCh38: Ensembl release ... Actin related protein 2/3 complex inhibitor". Retrieved 2017-06-21. Deng WS, Zhang J, Ju H, Zheng HM, Wang J, Wang S, Zhang DL ...
more infohttps://en.wikipedia.org/wiki/Actin_related_protein_2/3_complex_inhibitor
Arpc5l actin related protein 2/3 complex, subunit 5-like [Mus musculus (house mouse)] - Gene - NCBI  Arpc5l actin related protein 2/3 complex, subunit 5-like [Mus musculus (house mouse)] - Gene - NCBI
General protein information Go to the top of the page Help Preferred Names. actin-related protein 2/3 complex subunit 5-like ... mRNA and Protein(s) * XM_006498389.3 → XP_006498452.1 actin-related protein 2/3 complex subunit 5-like protein isoform X2 ... mRNA and Protein(s) * NM_028809.1 → NP_083085.1 actin-related protein 2/3 complex subunit 5-like protein ... actin related protein 2/3 complex, subunit 5-likeprovided by MGI. Primary source. MGI:MGI:1921442 See related. Ensembl: ...
more infohttps://www.ncbi.nlm.nih.gov/gene/?term=74192
actin related protein 2/3 complex subunit 5-like ELISA Kits | Biocompare.com  actin related protein 2/3 complex subunit 5-like ELISA Kits | Biocompare.com
Compare actin related protein 2/3 complex subunit 5-like ELISA Kits from leading suppliers on Biocompare. View specifications, ... actin related protein 2/3 complex subunit 5-like ELISA Kits. Clear ... actin related protein 2/3 complex subunit 5-like ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well- ... Bovine Actin-related protein 2/3 complex subunit 5-like protein (ARPC5L) ELISA Kit ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-2273513/ELISA_Kit/ELISA_actin_related_protein_23_complex_subunit_5-like
actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114): Novus Biologicals  actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114): Novus Biologicals
Rabbit Polyclonal Anti-actin-related protein 2/3 complex subunit 1B Antibody. Validated: WB, IHC, IHC-P. Tested Reactivity: ... Discover related pathways, diseases and genes to actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114). Need help ... Discover more about diseases related to actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114). ... Learn more about PTMs related to actin-related protein 2/3 complex subunit 1B Antibody (NBP1-90114). ...
more infohttps://www.novusbio.com/products/actin-related-protein-2-3-complex-subunit-1b-antibody_nbp1-90114
ARPC5 - Actin-related protein 2/3 complex subunit 5 - Homo sapiens (Human) - ARPC5 gene & protein  ARPC5 - Actin-related protein 2/3 complex subunit 5 - Homo sapiens (Human) - ARPC5 gene & protein
... mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis ... Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an ... Actin-related protein 2/3 complex subunit 5UniRule annotation. Automatic assertion according to rulesi ... tr,B1ALC0,B1ALC0_HUMAN Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=1 ...
more infohttps://www.uniprot.org/uniprot/B1ALC0
Arpc4 - Actin-related protein 2/3 complex subunit 4 - Mus musculus (Mouse) - Arpc4 gene & protein  Arpc4 - Actin-related protein 2/3 complex subunit 4 - Mus musculus (Mouse) - Arpc4 gene & protein
... a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 ... complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition ... repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks ( ... the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of ...
more infohttps://www.uniprot.org/uniprot/P59999
LOC686150 (similar to actin related protein 2/3 complex, subunit 5) - Rat Genome Database  LOC686150 (similar to actin related protein 2/3 complex, subunit 5) - Rat Genome Database
similar to actin related protein 2/3 complex, subunit 5 Symbol and Name status set to provisional. 70820. PROVISIONAL. ... Gene: LOC686150 (similar to actin related protein 2/3 complex, subunit 5) Rattus norvegicus. {{ watchLinkText }} ... Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer ( ... Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & ...
more infohttps://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1585449
ARPC1A (actin related protein 2/3 complex, subunit 1A) - KOMP (Knockout Mouse Project)  ARPC1A (actin related protein 2/3 complex, subunit 1A) - KOMP (Knockout Mouse Project)
OMIM: ACTIN-RELATED PROTEIN 2/3 COMPLEX, SUBUNIT 1A; ARPC1A*Gene Ontology: Arpc1a *Mouse Phenome DB: Arpc1a *UCSC: Chr.5: ... actin related protein 2/3 complex, subunit 1A. Synonyms: 0610010H08Rik, 1110030K07Rik, Sid32. Gene nomenclature, locus ...
more infohttps://www.komp.org/geneinfo.php?geneid=23773
Actin related protein 2/3 complex, subunit 5 | definition of actin related protein 2/3 complex, subunit 5 by Medical dictionary  Actin related protein 2/3 complex, subunit 5 | definition of actin related protein 2/3 complex, subunit 5 by Medical dictionary
What is actin related protein 2/3 complex, subunit 5? Meaning of actin related protein 2/3 complex, subunit 5 medical term. ... What does actin related protein 2/3 complex, subunit 5 mean? ... Looking for online definition of actin related protein 2/3 ... complex, subunit 5 in the Medical Dictionary? actin related protein 2/3 complex, subunit 5 explanation free. ... redirected from actin related protein 2/3 complex, subunit 5) ARPC5. A gene on chromosome 1q25.3 that encodes p16, one of the ...
more infohttp://medical-dictionary.thefreedictionary.com/actin+related+protein+2%2F3+complex%2C+subunit+5
ARPC5, Recombinant, Human, aa1-151, His-tag (Actin-related Protein 2/3 Complex Subunit 5 Protein, A | Proteins | Proteins and...  ARPC5, Recombinant, Human, aa1-151, His-tag (Actin-related Protein 2/3 Complex Subunit 5 Protein, A | Proteins | Proteins and...
... mediates the formation of branched actin networks. [The UniProt Consortium] ... Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an ... ARPC5, Recombinant, Human, aa1-151, His-tag (Actin-related Protein 2/3 Complex Subunit 5 Protein, A ... Customer review for "ARPC5, Recombinant, Human, aa1-151, His-tag (Actin-related Protein 2/3 Complex Subunit 5 Protein, A" ...
more infohttps://www.biomol.com/products/proteins-and-peptides/proteins/arpc5-recombinant-human-aa1-151-his-tag-actin-related-protein-2/3-complex-subunit-5-protein-a-a0760-89c.100
References | The Actin-Related Protein 2/3 Complex  References | The Actin-Related Protein 2/3 Complex
1997; 138(2):375-384. (2) Narayanan, A., LeClaire, L.L., Barber, D.L. andJacobson, M.P. Phosphorylation of the Arp2 subunit ... The human Arp2/3 complx is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin ... The Actin-Related Protein 2/3 Complex. Molecular Exploration Project - The Principles of Cellular Control (CELL2007) ... 1997; 138(2):375-384.. (2) Narayanan, A., LeClaire, L.L., Barber, D.L. andJacobson, M.P. Phosphorylation of the Arp2 subunit ...
more infohttps://arp23.wordpress.com/fasta/references/
Actin-related protein 2/3 complex subunit 1B  Actin-related protein 2/3 complex subunit 1B
HCA RNA Cell Line for Actin-related protein 2/3 complex subunit 1B. ... Compartment GO Terms for Actin-related protein 2/3 complex subunit 1B. ... This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The ... This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided ...
more infohttps://pharos.nih.gov/idg/targets/ARPC1B
Introduction | The Actin-Related Protein 2/3 Complex  Introduction | The Actin-Related Protein 2/3 Complex
... an actin monomer, a mother filament and a nucleation promoting-factor needed to activate the complex which is intrinsically ... Introduction The Arp2/3 complex is responsible for nucleation of actin filaments to form branches at a distinct 70 degrees ... Several factors are known to interact with the Arp2/3 complex, most… ... The Actin-Related Protein 2/3 Complex. Molecular Exploration Project - The Principles of Cellular Control (CELL2007) ...
more infohttps://arp23.wordpress.com/molecular-renderings/1-introduction/
Arpc3 - actin related protein 2/3 complex, subunit 3 | International Mouse Phenotyping Consortium  Arpc3 - actin related protein 2/3 complex, subunit 3 | International Mouse Phenotyping Consortium
Get highlights of the most important data releases, news and events, delivered straight to your email inbox. Subscribe to newsletter ...
more infohttps://www.wwww.mousephenotype.org/data/genes/MGI:1928375
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse....  Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse....
... the actin-nucleating formins, Diaphanous-1 (DIA1) and Formin-like-1 (FMNL1), did not affect TCR-stimulated F-actin-rich ... and formin-dependent F-actin nucleation during T cell activation. We demonstrated that without Arp2/3-mediated actin nucleation ... stimulated T cells could not form an F-actin-rich lamellipod, but instead produced polarized filopodia-like structures. ... Altogether, our results have identified Arp2/3 complex-independent cytoskeletal reorganization events in T lymphocytes and ...
more infohttps://www.semanticscholar.org/paper/Formins-regulate-the-actin-related-protein-2-3-com-Gomez-Kumar/af4e042e4f245c878d26e7bdf16548eddfae0931
Add your annotation to InterPro | InterPro | EMBL-EBI  Add your annotation to InterPro | InterPro | EMBL-EBI
Actin-related protein 2/3 complex subunit 3 superfamily (IPR036753). Add your Annotation. Your annotation. You may suggest ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR036753/add-annotation
ARPC2 Gene - GeneCards | ARPC2 Protein | ARPC2 Antibody  ARPC2 Gene - GeneCards | ARPC2 Protein | ARPC2 Antibody
Protein Coding), Actin Related Protein 2/3 Complex Subunit 2, including: function, proteins, disorders, pathways, orthologs, ... a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079 ... Protein details for ARPC2 Gene (UniProtKB/Swiss-Prot). Protein Symbol:. O15144-ARPC2_HUMAN. Recommended name:. Actin-related ... ARPC2 Gene (Protein Coding) Actin Related Protein 2/3 Complex Subunit 2. ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=ARPC2
ARPC3P3 Gene - GeneCards | ARPC3P3 Pseudogene  ARPC3P3 Gene - GeneCards | ARPC3P3 Pseudogene
... proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Actin Related Protein 2/3 Complex Subunit 3 Pseudogene 3, including: function, ... ARPC3P3 (Actin Related Protein 2/3 Complex Subunit 3 Pseudogene 3) is a Pseudogene. ... Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ARPC3P3 ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=ARPC3P3
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. (nih.gov)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
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  • Endocytosis, organism-specific biosystem Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. (nih.gov)
  • Your search returned 43822 (a)3 ELISA ELISA Kit across 69 suppliers. (biocompare.com)
  • AMPK was mixed with a fixed amount of F-actin in the presence or absence of α-actinin and GST-Pdlim5, incubated for 1 h at 24 °C and then centrifuged at 150,000 g for 1.5 h at 24 °C, to pellet the F-actin polymer and associated proteins. (nih.gov)
  • The central role of EED in the orchestration of polycomb group complexes. (nih.gov)
  • This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. (nih.gov)
  • These findings indicate that Pdlim5 binds AMPK directly and promotes the recruitment of AMPK onto F-actin, a process mediated by α-actinin. (nih.gov)
  • Augmented AMP-activated protein kinase (AMPK) activity inhibits cell migration, possibly contributing to the clinical benefits of chemical AMPK activators in preventing atherosclerosis, vascular remodelling and cancer metastasis. (nih.gov)
  • Predicted to have actin filament binding activity. (jax.org)
  • The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. (nih.gov)