Modification of radiosensitivity by the so-called tissue recovery stimulator. I. Radiosensitizing effects of solcoseryl. (1/4)

The effect of solcoseryl on the growth, radiosensitization and ability of V79 cells to recover from X-ray-induced damage has been observed. Solcoseryl at 0.8 mg/ml was the optimal concentration for the stimulation of cell growth. Increased sensitivity to X-irradiation was found in the shoulder region of V79 cells treated before and after irradiation with solcoseryl (0.8 mg/ml). The Dq and extrapolation number (n) decreased. Solcoseryl treatment apparently does not reduce split dose recovery or inhibit the repair of potentially lethal damage. Flow cytofluorometry studies of the cell cycle distribution and mitotic index show that solcoseryl inhibits the expression of radiation-induced cell arrest in the G2 phase of the cell cycle. Although this action increases radiation sensitization, additional mechanisms probably exist.  (+info)

Stimulation of oxygen consumption of platelets by Solcoseryl and cardiocrome during in vitro aging for 5 days. (2/4)

Solcoseryl (SOL) and Cardiocrome (CAR) produced decreases in the partial oxygen pressure of platelet suspensions, indicating the acceleration of platelet oxygen consumption. However, the peak response to CAR was much faster than that to SOL. Application of 1 ml of SOL to 20 ml of platelet suspension stored for 1 day produced increases of 1 nmol ATP per min per 10(9) platelets. The same increases in oxygen consumption appeared after 3 or 5 day-storage.  (+info)

Effect of elcatonin on experimental gastric and duodenal ulcers. (3/4)

The antiulcer action of elcatonin, an analogue of natural eel calcitonin, was compared with that of cimetidine, secretin and solcoseryl. Elcatonin (3 to 10 mu/kg, s.c.) inhibited the development of gastric ulcers induced by pylorus ligation, water-immersion stress, aspirin and reserpine and duodenal ulcers induced by cysteamine in rats. Moreover, once daily injections of elcatonin (1 to 10 mu/kg/day, s.c.) promoted the healing of acetic acid-induced chronic gastric ulcers not only in rats but in dogs. The healing effect persisted after the cessation of administrations. Cimetidine (30 to 100 mg/kg, p.o.) inhibited the development of gastric ulcers induced by water-immersion stress, aspirin and reserpine and duodenal ulcers induced by cysteamine in rats. However, once daily administrations of cimetidine (30 to 100 mg/kg/day, p.o.) did not show significant effect on acetic acid-induced chronic gastric ulcers in rats. Secretin (30 to 100 mu/kg, s.c.) inhibited the development of gastric ulcers induced by pylorus ligation, water-immersion stress, aspirin and reserpine in rats, but was not effective on cysteamine-induced duodenal ulcers and acetic acid-induced chronic gastric ulcers in rats. Solcoseryl (2 ml/kg, s.c.) inhibited only the development of water-immersion stress-induced gastric ulcers in rats. These results suggest that elcatonin is different from these reference drugs in its properties of action on experimental ulcers. Mechanisms of the antiulcer action of elcatonin which has a superior effect on experimental ulcers are discussed.  (+info)

Effect of a deproteinized blood extract on the recovery of blood circulation in an ischaemic skin lesion. (4/4)

An experimental model was used to study the revascularization of an ischaemic skin lesion and the effect on this process of the blood extract Solcoseryl. Under the conditions given in the experiment, restoration of the circulation was by 2 modes--re-flow in the original vessels, and neovascularization. Solcoseryl given daily i.p. encouraged the re-flow phenomenon and therefore, by improving the microcirculation and nutrition, the healing of the ischaemic lesions.  (+info)

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Context: Carica papaya L. (Caricaceae) fruit was shown to exhibit wound healing properties. Objectives: We investigated anti-inflammatory and antioxidant potential of papaya fruit phosphate-buffered saline extract (PE) during wound healing and enhancement of the potentials due to trace ions addition. Materials and methods: Rat excision wounds were topically treated twice/day with 20 μL of PE (5 mg extract/mL), 0.5 μg Se2+ added PE (PES), or 100 μM Zn2+ added PE (PEZ). Control groups were treated with deionized water (negative) and deproteinized calf blood extract ointment (Solcoseryl®, positive). Lipid peroxidation (LPX), antioxidant, proinflammatory, and arginine metabolic enzymes were estimated in the wound excised on days 4 and 10 post wounding. Results: PE (5 mg/mL; 9.80 ± 0.33 d) and PES (PE + 0.5 μg Se2+; 8.90 ± 0.23 d) significantly (p , 0.05) reduced the average time for complete wound closure compared with the negative (13.00 ± 0.37 d) and positive (9.80 ± 0.33 d) controls, ...
Elcatonin, 0.1 g. |p class=db_paraghraph|Elcatonin is a Calcitonin derivative which is transformed from eels calcitonin by changing the S-S bond into the stable C-N bond.
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Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis Jun Iwamoto1, Mitsuyoshi Uzawa2, Yoshihiro Sato3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, Japan; 3Department of Neurology, Mitate Hospital, Fukuoka, Japan Abstract: The antiresorptive drug elcatonin (ECT) is known to relieve pain in postmenopausal women with osteoporosis. A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. Two hundred and five postmenopausal osteoporotic women (mean age: 70 years) were recruited in our outpatient clinic. Forty-six women with back pain were treated
... actihaemyl MeSH D20.777.162 --- cell extracts MeSH D20.777.351 --- liver extracts MeSH D20.777.500 --- pancreatic extracts MeSH ...
Rammler L. Actihaemyl/ATP-Konzentrationen in Meerschweinchen-Gerhirnhomogenaten. Internal Company Report, Pharmakologische ... Bachmann H. Wirkung von Actihaemyl auf den Kohlenhydratstoffwechsel - Untersuchungen in vivo; Dissertation, Medizinische ...
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... actihaemyl MeSH D20.777.162 --- cell extracts MeSH D20.777.351 --- liver extracts MeSH D20.777.500 --- pancreatic extracts MeSH ...
Csaba, D., Kálmán, H., Elek, B., Attila, N., Gábor, B., Gábor, S., Zoltán, S., Gábor, B., Mária, W., Ildikó, G. & Katalin, S., Jan 2007, In : Magyar sebészet. 60, 1, p. 494-500 7 p.. Research output: Contribution to journal › Article ...
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Clement CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med. 2008 Jun 15; 177(12):1322-30 ...
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Actihaemyl Adenosine Triphosphate Anti-Bacterial Agents Arterial Occlusive Diseases Drug Therapy, Combination Female Humans ...
This graph shows the total number of publications written about "Thymus Extracts" by people in this website by year, and whether "Thymus Extracts" was a major or minor topic of these publications ...
Extracts prepared from pancreatic tissue that may contain the pancreatic enzymes or other specific uncharacterized factors or proteins with specific activities. PANCREATIN is a specific extract containing digestive enzymes and used to treat pancreatic insufficiency ...

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