ACTH Syndrome, Ectopic: Symptom complex due to ACTH production by non-pituitary neoplasms.Management Information Systems: Systems designed to provide information primarily concerned with the administrative functions associated with the provision and utilization of services; also includes program planning, etc.Paraneoplastic Endocrine Syndromes: Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion.Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.17-Hydroxycorticosteroids: A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.Adrenocortical Hyperfunction: Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.AxisTeaching Materials: Instructional materials used in teaching.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Competitive Behavior: The direct struggle between individuals for environmental necessities or for a common goal.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Libraries, DentalSpondylolisthesis: Forward displacement of a superior vertebral body over the vertebral body below.Mifepristone: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.Abortifacient Agents, Steroidal: Steroidal compounds with abortifacient activity.Hormone Antagonists: Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.Misoprostol: A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.Abortifacient Agents, Nonsteroidal: Non-steroidal chemical compounds with abortifacient activity.Contraceptives, Postcoital, Synthetic: Postcoital contraceptives which owe their effectiveness to synthetic preparations.Abortifacient Agents: Chemical substances that interrupt pregnancy after implantation.Otolaryngology: A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.Esthesioneuroblastoma, Olfactory: A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)Digestive System Fistula: An abnormal passage communicating between any components of the digestive system, or between any part of the digestive system and surrounding organ(s).Otorhinolaryngologic Diseases: Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.Nose Neoplasms: Tumors or cancer of the NOSE.Nasal Cavity: The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.Otorhinolaryngologic Surgical Procedures: Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.European Union: The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Biosimilar Pharmaceuticals: BIOLOGIC PRODUCTS that are imitations but not exact replicas of innovator products.Legislation, Drug: Laws concerned with manufacturing, dispensing, and marketing of drugs.Therapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.EuropeUnited States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Sacrococcygeal Region: The body region between (and flanking) the SACRUM and COCCYX.Coccyx: The last bone in the VERTEBRAL COLUMN in tailless primates considered to be a vestigial tail-bone consisting of three to five fused VERTEBRAE.Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.Teratoma: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)Receptors, Somatostatin: Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.Octreotide: A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.Somatostatin: A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Adenoma: A benign epithelial tumor with a glandular organization.

Severe muscle weakness due to hypokalemia as a manifestation of small-cell carcinoma. (1/112)

We describe the case of a 56-year-old man with severe muscle weakness due to heavy hypokalemia (serum potassium 1.44 mmol/l) associated with inappropriate kaliuria and alkalemia. Subsequent investigation revealed the presence of ectopic ACTH hypersecretion due to a small-cell lung carcinoma. A significant clinical/laboratory improvement was achieved following chemotherapy-induced regression of the primary tumor. The profound hypokalemia was probably the result of cortisol hypersecretion, which in concert with the ACTH-induced decreased 11beta-hydroxysteroid dehydrogenase activity can exhibit an increased mineralocorticoid activity. In addition, other ACTH-dependent mineralocorticoids may play a contributory role in the development of severe hypokalemia.  (+info)

Carcinoid-associated ectopic ACTH syndrome with variable response to octreotide. (2/112)

The case is presented of a 31-year-old woman who developed florid clinical and biochemical Cushing's syndrome due to metastatic hepatic carcinoid tumour from a probable pancreatic primary. Hypercortisolaemia was controlled with metyrapone and ketoconazole, but high doses of octreotide failed to affect plasma cortisol and urinary 5-hydroxyindole acetic acid (5HIAA) levels, or prevent rapid tumour growth. Hepatic polystyrene embolisation failed, and she was treated by liver transplantation with initial excellent results, and normalisation of cortisol and 5HIAA levels. Ten months later, however, she relapsed with bony and pelvic tumour recurrence, and high and symptomatic levels of cortisol and 5HIAA. At this time, octreotide in similar doses to those used previously appeared to normalise her biochemically, although she died soon after. This variable responsiveness to octreotide could be related to somatostatin receptor changes, or cyclical tumour secretion patterns.  (+info)

Marked increase in plasma ACTH with tumor reduction after chemotherapy in ectopic ACTH syndrome. (3/112)

We report on a case of rapid and marked hormone release as a result of rapid tumor reduction due to chemotherapy in a 36-year-old woman with ectopic ACTH syndrome due to small cell lung cancer. Treatment of the cancer with cisplatin and etoposide resulted in an 80% reduction in tumor size on computed tomographic scan within two weeks. Concurrently, plasma ACTH exhibited an unexpected and astonishing increase from 373 pg/ml before treatment to more than 1200 pg/ml. There were no biochemical characteristics observed in tumor lysis syndrome of solid tumors such as azotemia, increased LDH and hyperkalemia. The present case indicates that anticancer chemotherapy instituted in patients with ectopic ACTH syndrome could result in an acute increase of plasma ACTH and exacerbation of hypercortisolism, similar to tumor lysis syndrome, which is a potentially fatal complication following anti-cancer chemotherapy.  (+info)

Is whole-lung CT scanning still necessary in all cases of ACTH-dependent Cushing's syndrome in the era of petrosal sinus sampling? (4/112)

We reviewed 31 patients in whom both bilateral inferior petrosal sinus sampling without CRH stimulation, and a CT scan of the lungs were done. Twenty-five had normal lung CT scans, of whom 23 had a higher inferior petrosal sinus: peripheral ACTH ratio > or = 1.5. After careful follow-up, none was subsequently shown to have ectopic ACTH syndrome. Six had abnormal lung CT scans, of whom two had ratios > or = 1.5. In these two patients, other investigations suggested pituitary disease, and pituitary surgery led to apparent cure. Of the remaining four patients, who had ratios < 1.5, two had incidental lung findings, and pituitary abnormalities were demonstrated at pituitary surgery. The third underwent bilateral adrenalectomy, and no evidence of ectopic ACTH syndrome has emerged as yet after 4 years follow-up. The fourth had a small-cell carcinoma of the lung, confirmed histologically. Our series suggests that whole-lung CT scanning is only necessary in cases of ACTH-dependent Cushing's syndrome where bilateral inferior petrosal sinus sampling has not demonstrated a significant increase in petrosal sinus ACTH levels as compared with the peripheral level. Thus, in our experience the test is now only necessary in those patients (approximately 25%) where the ratio is < or = 1.5.  (+info)

Thymic hyperplasia as a source of ectopic ACTH production. (5/112)

A 26 year-old man with suspected Cushing's disease underwent transsphenoidal exploration of the pituitary without any evidence of microadenoma or hyperplasia. Progressive hypercortisolism necessitated bilateral adrenalectomy. Postoperatively, skin pigmentation gradually developed with a marked elevation of plasma ACTH levels, and CT scanning uncovered a thymic mass. Following removal of the thymic mass, skin pigmentation disappeared and plasma ACTH levels fell to normal. The excised mass was found to be a benign thymic hyperplasia without epithelial or carcinoid tumor cells. However, gel chromatography showed that the thymic tissue extract contained high ACTH content comparable to that of ectopic ACTH-producing tumors with a major component corresponding to ACTH(1-39). Northern blot analysis and in situ hybridization revealed the expression of proopiomelanocortin transcripts in lymphocytes of thymic hyperplasia. This report suggests that lymphocytes in thymic hyperplasia are the most likely site of deregulated ACTH expression causing ectopic ACTH syndrome.  (+info)

Clinical implications of glucocorticoid metabolism by 11beta-hydroxysteroid dehydrogenases in target tissues. (6/112)

11beta-Hydroxysteroid dehydrogenases (11beta-HSD) are microsomal enzymes that catalyze the conversion of active glucocorticoids (GC) to their inactive 11-dehydro products and vice versa. Two isoenzymes of 11beta-HSD have been characterized and cloned in human tissues. The tissue-specific metabolism of GC by these enzymes is important for mineralocorticoid (MC) and GC receptor occupancy and seems to play a crucial role in the pathogenesis of diseases such as apparent MC excess syndrome, and may play roles in hypertension, obesity and impaired hepatic glucose homeostasis. This article reviews the literature and examines the role and importance of 11beta-HSD in humans.  (+info)

A new generation IRMA for ACTH with improved specificity: validation in various physiological and pathological conditions. (7/112)

OBJECTIVE: Measurement of plasma ACTH is a key step for the exploration of hypothalamic-pituitary-adrenal disorders. To further improve ACTH recognition a new generation of ACTH IRMA was developed using antibodies directed towards succinylated ACTH (sACTH IRMA). DESIGN: The usefulness of this assay was compared with that of another commercially available ACTH IRMA assay using intact ACTH (ELSA-ACTH) in various pathophysiological situations: patients with low ACTH plasma levels, high ACTH plasma levels with normal or tumoural pituitaries, or ectopic ACTH syndrome, and pregnant women with high proopiomelanocortin (POMC) plasma levels. METHODS: All plasma samples were assayed simultaneously with the two different IRMAs. Comparisons were assessed by plotting the results along the theoretical line of identical values, and by the graphical method of Bland and Altman. RESULTS: In the ELSA-ACTH IRMA, CLIP (or ACTH18-39) showed true cross-reactivity, and alpha-melanocyte-stimulating hormone and purified POMC both interfered and induced falsely lower ACTH results; in the sACTH IRMA no peptide showed any cross-reactivity, and only extremely high values of CLIP (50 000 pg/ml) interfered and induced falsely lower ACTH results. In ACTH hypersecretory syndromes, of tumoural (Cushing's disease, ectopic ACTH secretion) or non-tumoural (Addison's disease, congenital adrenal hyperplasia) origins a good agreement between the two assays was observed except for very high ACTH plasma values (above 1000 pg/ml) and in some tumours where the sACTH IRMA yielded lower results; in some cases, the presence of circulating CLIP, demonstrated by HPLC studies, may contribute to this discrepancy. It is also likely that the calibration of the ELSA-ACTH kit itself generates higher ACTH values. In normal pregnant women both IRMAs gave highly correlated values, yet lower results were obtained with the sACTH IRMA. CONCLUSION: These data show that the sACTH IRMA has improved qualities of specificity and usefulness for rapid assessment of ACTH plasma levels.  (+info)

Ectopic adrenocorticotropin syndrome exhibiting paradoxical adrenocorticotropin responsiveness to gonadotropin-releasing hormone. (8/112)

In a 37-year-old man who had Cushing's syndrome, investigations, including overnight dexamethasone suppression test, corticotropin-releasing hormone (CRH) test, pituitary MRI and inferior petrosal sinus sampling suggested the presence of ectopic adrenocorticotropin (ACTH) production. Interestingly, gonadotropin-releasing hormone (GnRH) increased plasma ACTH from 73 pg/ml to 708 pg/ml at 15 min. Furthermore, desmopressin also increased plasma ACTH whereas CRH and thyrotropin-releasing hormone (TRH) had no effect. Such paradoxical responses of plasma ACTH were observed repeatedly. A thoracic CT scan revealed a right anterior mediastinal mass, which was surgically resected. Histological and immunohistochemical examination confirmed that the tumor was an ACTH-producing carcinoid. ACTH and cortisol decreased immediately following surgery. Neither desmopressin nor GnRH administration resulted in elevation of plasma ACTH while ACTH-responsiveness to dexamethasone and CRH was restored. To our knowledge, this is the first report documenting GnRH responsiveness in ectopic ACTH syndrome.  (+info)

Ectopic secretion of ACTH is an infrequent cause of Cushings syndrome. We report a case of ectopic ACTH syndrome caused by a nasal paraganglioma, a 68-year-old female with clinical features of Cushings syndrome, serious hypokalaemia and a right paranasal sinus lesion. Cranial magnetic resonance image showed a 46-mm mass on the right paranasal sinuses. Endocrinological investigation confirmed the diagnosis of ectopic ACTH production. Resection of the tumour normalised ACTH and cortisol secretion. The tumour was found to be a paraganglioma through microscopic analysis. On follow-up 3 months later, the patient showed nearly complete clinical recovery. Ectopic ACTH syndrome due to nasal paraganglioma is extremely uncommon, as only two other cases have been discussed in the literature. ...
Ectopic secretion of ACTH is an infrequent cause of Cushings syndrome. We report a case of ectopic ACTH syndrome caused by a nasal paraganglioma, a 68-year-old female with clinical features of Cushings syndrome, serious hypokalaemia and a right paranasal sinus lesion. Cranial magnetic resonance image showed a 46-mm mass on the right paranasal sinuses. Endocrinological investigation confirmed the diagnosis of ectopic ACTH production. Resection of the tumour normalised ACTH and cortisol secretion. The tumour was found to be a paraganglioma through microscopic analysis. On follow-up 3 months later, the patient showed nearly complete clinical recovery. Ectopic ACTH syndrome due to nasal paraganglioma is extremely uncommon, as only two other cases have been discussed in the literature. ...
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Secretion of ectopic adrenocorticotropic hormone (ACTH) with consequently Cushings syndrome is a rare paraneoplastic phenomenon. It has been described in a variety of malignancies, like bronchial carcinoids, small-cell lung carcinoma, thymoma, pancreatic carcinoma and other. In many cases of suspected ectopic ACTH secretion, it is difficult to histologically or cytochemically confirm the diagnosis. We present a 63-year-old woman with a recurrent poorly differentiated squamous cell lung carcinoma with clinical and biochemical features consistent with ectopic Cushings syndrome. Immunocytochemical staining confirmed the secretion of ACTH by tumour cells. (c) 2005 Elsevier Ireland Ltd. All rights reserved. ...
Results: Patients (n=124) with Cushings disease had younger age (40.4±11.6 vs. 53.4±16.1 years), longer disease courses (24.0 vs. 3.0 months) and greater diastolic blood pressure (95±14 vs. 87±11 mmHg) than those (n=17) with ectopic adrenocorticotropic hormone (ACTH) syndrome (P,0.05). Compared with ACTH independent syndrome (n=85), ACTH dependent syndrome (n=141) had significantly (P,0.05) lower potassium (3.30±0.68 vs 3.58±0.62mmol/L) and chloride (101.8±5.2 vs. 104.3±4.2 mmol/L) but significantly (P,0.05) greater pH value, bicarbonate radicals, base excess, and CO2CP/K ratio (9.3±4.6 vs 7.5±2.4). Compared with patients with Cushings disease, patients with ectopic ACTH syndrome had significantly (P,0.05) lower potassium (2.33±0.54 vs. 3.42±0.59) and chloride (97.3±6.4 vs. 102.5±4.6 mmol/L) but significantly (P,0.05) greater pH value, bicarbonate radical, base excess, and CO2CP/K ratio (15.98±7.6 vs. 8.1±2.6). Analysis of the ROC curve with the ACTH dependent vs. independent ...
At a Glance Ectopic ACTH syndrome (EAS) is caused by nonpituitary tumors that secrete either adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing hormone (CRH) and cause bilateral adrenal hyperplasia. Clinical presentation resembles Cushings syndrome (CS): amenorrhea, hirsutism, hypertension, impotence, muscular wasting, skin atrophy, neuropsychiatric dysfunction, osteoporosis, truncal-central obesity, weight gain-water retention, moon face, weakness, fatigue, backache, headache,…. ...
Cushings Disease: This syndrome is caused by tumors on the ACTH secreting cells of the pituitary gland. patients with this problem develop fat deposits in strange places , spontaneous scarring of the skin along the belly that looks striated, pimples in adult, high blood pressure and elevated body temperature. These tumors are usually so small that the surgeon might have a difficult time finding the little "bad pearl" in the gland during surgery. This is the one time when small can be bad, especially if the surgeon is unable to locate and remove the tumor! ACTH secreting tumors, although small and troublesome, are readily cured by surgery alone" Pituitary adenomas have been known to make levels of ACTH rise and fall, Thus making cortisol do the same.Id would be asking for another MRI of the Pituitary gland. Or possibly Ectopic ACTH syndrome or Ectopic CRH syndrome where the tumor is elsewhere in the body ...
Since doctors could now use genetic testing to tell at birth due to a random error that occurs in the lupus like syndrome to diseases of circulatory system particularly due to ectopic ACTH syndrome and other injuries are becoming more and more common among individuals with pure 45 X, monosomy. Studies carried out with other karyotypes have shown different types of malformations associated with Chronic Fatigue Syndrome symptoms often exasperate my Fibromyalgia issues and vice versa. Far too many times a string of sleepless nights has heralded a wave of back pain or intense pain in my hip that has made it impossible to get any sleep.. In general females carry two X chromosomes while males have one X chromosome. In some cases the inactivated X chromosome whose alteration result in Down syndrome was found. In the lupus like syndrome, one doctor theorized that Down Syndrome became standard treatment. One other theory was that babies with Down syndrome must be changed and it occurs when one of the ...
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008 ...
Cushing Syndrome is an endocrine disorder causing an over production of the hormone cortisol. Cortisol is produced in the adrenal gland as a response to the production of ACTH in the pituitary gland.. Between 10% and 20% of patients with hypercortisolism (Cushing Syndrome) have ectopic production of the hormone ACTH. Meaning, the hormone is not being released from the normal site, the pituitary gland. In many cases the ectopic ACTH is being produced by a tumor of the lung, thymus, or pancreas. However, in approximately 50% of these patients the source of the ACTH cannot be found even with the use of extensive imaging studies such as CT scans, MRIs, and nuclear scans (111-indium pentetreotide). The ability of these tests to locate the source of the hormone production is dependent on the changes of anatomy and / or the dose and adequate uptake of the radioactive agent. The inability to detect the source of ectopic ACTH production often results in unnecessary pituitary surgery or ...
Cushing Syndrome is an endocrine disorder causing an over production of the hormone cortisol. Cortisol is produced in the adrenal gland as a response to the production of ACTH in the pituitary gland.. Between 10% and 20% of patients with hypercortisolism (Cushing Syndrome) have ectopic production of the hormone ACTH. Meaning, the hormone is not being released from the normal site, the pituitary gland. In many cases the ectopic ACTH is being produced by a tumor of the lung, thymus, or pancreas. However, in approximately 50% of these patients the source of the ACTH cannot be found even with the use of extensive imaging studies such as CT scans, MRIs, and nuclear scans (111-indium pentetreotide). The ability of these tests to locate the source of the hormone production is dependent on the changes of anatomy and / or the dose and adequate uptake of the radioactive agent. The inability to detect the source of ectopic ACTH production often results in unnecessary pituitary surgery or ...
As a general rule all human beings contain 23 pairs of chromosomes and all these factors that crop up due to ectopic ACTH syndrome, it is always beneficial to remove all the stevens johnson syndrome literature of body. All humans inherit 23 chromosomes from the stevens johnson syndrome literature from Down syndrome attain same hormonal changes during puberty like the polycystic ovarian syndrome that may accompany it.. Archaeologists have found statues made by tribes that lived in Central America somewhere between 1500 and 300 BC that seem to have it. Injuries such as tendonitis, bursitis, and other similar injuries continue to increase, and afflict younger and younger individuals, questions arise as to how relevant a link exists between carpal tunnel in the stevens johnson syndrome literature by Jean Etienne Dominique Esquirol in 1838 and Edouard Senguin 1844. Dr. Jerome Lejeune in 1959 identified that Down Syndrome has always been with us, but it was named as Down syndrome get paid employment ...
What Is Cushings? Cushings syndrome, also known as hypercortisolism or hyperadrenocorticism, is an endocrine disorder caused by prolonged exposure of the bodys tissues to high levels of the hormone cortisol (in the blood) from a variety of causes, including primary pituitary adenoma (known as Cushings disease), primary adrenal hyperplasia or neoplasia, ectopic ACTH production (e.g., from a small cell lung cancer), and iatrogenic (steroid use). It is relatively rare and most commonly affects adults aged 20 to 50. An estimated 10 to 15 of every million people are affected each year. Cushings was discovered by American physician, surgeon and endocrinologist Harvey Cushing (1869-1939) and reported by him in 1932. Normally, cortisol is released from the adrenal glands in response to ACTH being released from the pituitary gland. Both Cushings syndrome and Cushings disease are characterized by elevated levels of cortisol in the blood, but the cause of elevated cortisol differs between the two. ...
Wojcik M, Kalicka-Kasperczyk A, Luszawska-Kutrzeba T, Balwierz W, Starzyk J. The first description of metyrapone use in severe Cushing Syndrome due to ectopic ACTH secretion in an infant with immature sacrococcygeal teratoma. Case Report. Neuro Endocrinol Lett. 2015 Dec; 36(7): 653-655 ...
This drug was approved for use in patients with endogenous Cushings syndrome who have type 2 diabetes or glucose intolerance and are not candidates for surgery or who have not responded to prior surgery. Korlym should never be used (contraindicated) by pregnant women.. Prior to FDAs approval of Korlym, there were no approved medical therapies for the treatment of endogenous Cushings syndrome.. Endogenous Cushings syndrome is a serious, debilitating and rare multisystem disorder. It is caused by the overproduction of cortisol (a steroid hormone that increases blood sugar levels) by the adrenal glands. This syndrome most commonly affects adults between the ages of 25 and 40. About 5,000 patients will be eligible for Korlym treatment, which received an orphan drug designation by the FDA in 2007.. Korlym blocks the binding of cortisol to its receptor. It does not decrease cortisol production but reduces the effects of excess cortisol, such as high blood sugar levels.. The safety and efficacy of ...
This video explains Cushings syndrome and how to differentiate between different types of Cushings syndrome and also how to treat Cushings syndrome ...
Cushings syndrome was first discovered by Harvey Cushing. In this situation, your body is damaged by an overload of cortisol. This can cause diabetes, high blood pressure and slow metabolism. - Cushings syndrome - Slow Metabolism - Low Carb at BellaOnline
Cushings Syndrome Definition - Cushings syndrome is a disorder that occurs when the body is exposed to abnormally high levels of the hormone...
Information about this survey and your consent to participate Patients with Cushings syndrome report decreased quality of life before and after surgical treatment. We are investigators at the U.S. National Institutes of Health who care for patients with Cushings syndrome. We want to learn more about the patients experience during the post-surgical recovery phase with…
Thirty-four patients with Cushings Syndrome: our clinical experience in the past 20 years/ Otuz dort Cushings Sendromu olgusu: 20 yillik klinik deneyimlerimiz.
Too much cortisol in the body isnt just a sign of stress; it can also lead to Cushings syndrome (hypercortisolism). Learn about causes, symptoms and prevention.
As this eMedTV Web page explains, Cushings disease can cause symptoms like weight gain, fatigue, excessive hair growth, and hypertension. This article identifies several other possible signs and symptoms of this condition.
Shares of Corcept Therapeutics Inc. soared 57 percent in extended trade Friday, after the U.S. Food and Drug Administration approved Korlym as the first therapy to treat high blood sugar in adults suffering from a hormonal disorder called endogenous Cushings syndrome.
SILVER SPRING, Md., Feb. 17, 2012 /PRNewswire-USNewswire/ -- FDA Approves Korlym for Patients With Endogenous Cushings Syndrome.
Cushings syndrome is considered to be a rare disorder that results from prolonged exposure to glucocorticoids. However, there are few epidemiological studies to provide adequate data to describe the incidence and prevalence of the condition accurately. Most cases are diagnosed between the ages of 20 and 50, although any individual may be affected at any age.
D. Lynn Loriaux, M.D., Ph.D. N Engl J Med 2017; 376:1451-1459April 13, 2017DOI: 10.1056/NEJMra1505550 More than a century ago, Harvey Cushing introduced the term
When it comes to traveling in a car with your dog, safety should be paramount for you both. However, a recent study from Volvo Car USA found some surprising statistics. ...
elevated ACTH - MedHelps elevated ACTH Center for Information, Symptoms, Resources, Treatments and Tools for elevated ACTH. Find elevated ACTH information, treatments for elevated ACTH and elevated ACTH symptoms.
Bronchial carcinoid tumors are very rare pulmonary neoplasms. They usually present with pulmonary symptoms or paraneoplastic syndromes. Typical (well-differentiated) tumors are usually indolent with survival exceeding 90% after resection. Atypical carcinoids have a worse prognosis. They are much more likely to recur locally or to have distant metastases. This case report describes a patient who presented with abdominal pain and hepatic lesions who was subsequently diagnosed to have bronchial carcinoid.
Include only abbreviations used in the text being indexed (ie, if a text uses only an expanded form, eg, National Institutes of Health, but never the abbreviation, do not include "NIH" in the index). Abbreviations are listed alphabetically among other entries (examples from Thomas,). catheterization CAT scan. See computed tomography cat-scratch disease CEA (carcinoembryonic antigen) cecum ectopic ACTH syndrome, 106, 107, 109 ectopic kidney, 2226 ectopic pregnancy, 1947, 2055 2056 Identical abbreviations are sorted by case; be consistent throughout the index, eg, HeV, 232 HEV, 330 331 PaO2, 464 PAO2, 251 Use cross-references and expansions with abbreviations, as in these Less ...
Ectopic adrenocorticotropic hormone secretion is responsible for 12% to 17% of all cases of the Cushing syndrome. One of the most commonly described causes of ectopic adrenocorticotropic hormone secretion is small cell carcinoma of the lung. A rare c
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of "NTU Repository" with "Academic Hub" to form NTU Scholars.. ...
en] Cushings syndrome (CS) is characterized by pathologically elevated free glucocorticoid levels. Endogenous hypercortisolism is usually due to ACTH-secreting pituitary corticotropic adenomas and less often due to ectopic ACTH-secreting neuroendocrine neoplasms or ACTH-independent adrenal cortisol hypersecretion. CS is a serious chronic disease leading to a several-fold increase in cardiovascular morbidity and mortality. Multiple genetic alterations have been described in the setting of sporadic corticotropinoma formation. Changes in the expression profiles have been demonstrated in growth factors and their receptors, cell-cycle regulators and in various genes related to hormonal gene transcription, synthesis and secretion. Sporadic adrenal adenomas and carcinomas may demonstrate dysfunction in genes such as TP53 among others. Cushings disease can be an inherited condition also. Multiple endocrine neoplasia type 1 (MEN1) and familial isolated pituitary adenomas (FIPA) together account for 5% ...
Diagnosis of Cushings Syndrome. William Harper, MD, FRCPC Endocrinology & Metabolism Assistant Professor of Medicine McMaster University. Nomenclature. Cushings Syndrome Hypercortisolism of any cause Cushings Disease Corticotropin (ACTH) secreting pituitary adenoma....
Learn about the causes, symptoms, diagnosis & treatment of Tumors of the Lungs from the Professional Version of the Merck Manuals.
Diabetes mellitus (DM) is a common comorbidity of Cushings syndrome (CS) and plays an important role in morbidity and death of patients with uncontrolled hypercortisolism. Some authors define DM in CS as a specific type of diabetes secondary to endocrinopathy, although others judge it as a classical form of type 2 DM. Glucocorticoid (GC) excess causes pancreatic beta cell dysfunction and insulin resistance, which correlates with hypercortisolism level. If Cushings disease (CD) remission implicates on DM resolution remains unclear. ...
This article is a comprehensive overview of Cushings syndrome, which is caused by excess production of the hormone cortisol by the adrenal cortex. Learn about the history of this disease, along with the symptoms, diagnosis, and treatments for Cushings s
Cushings syndrome (hyperadrenocorticism) is a condition in which there is an excess of cortisol. It may be caused by drugs, such as prednisone, or by an excess of the bodys own cortisol, caused by a pituitary or adrenal tumor.
Learn more about Cushings Syndrome at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Cushings Syndrome report provide key market insights with Prevalent & Incident Cases by 7 MM-2013-2023 for United States, United Kingdom, Germany, France, Spain, Italy and Japan
Cushings Syndrome is a very stressful disease, but there are many remedies, including reducing stress, exercising regularly and altering your diet.
6. I have had a lot of headaches that are dull and constant behind my eyes like and into my neck - and I cant seem to get rid of them... Ive found myself taking tylenol everyday lately - but Im not sure if it helps. And I cant take ibuprofen b/c I am on Prozac (40mg) and buspar (20mg) a day for severe (suicidal) depression - I only developed around the same time I started sleeping so much and gaining weight (mid 2010ish) I am 100% better on the medication, but it seems my body did not catch up ...
Disclaimer: The information provided on HealthWorld Online is for educational purposes only and IS NOT intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek professional medical advice from your physician or other qualified healthcare provider with any questions you may have regarding a medical condition ...
(HealthDay)-Patients with Cushings syndrome have abnormal brain metabolites suggestive of neuronal dysfunction even after they appeared to have been cured, according to a study presented at the annual European Congress ...
Introduce yourself and tell us about your dog, ask questions about and discuss diagnosis and treatment options for Canine Cushings here
Page 3 - Generally, as the ICP rises and results in cushings response, the pulse pressure widens. Systolic goes up, diastolic goes down. I am wondering- what causes the diastolic pressure to drop? Thanks
Study Flashcards On cushings at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Adults with Cushings syndrome who use Korlym may find this drug can help control blood sugar levels. This eMedTV Web page contains an in-depth look at specific uses of this medicine, including whether it is safe for children and older adults.
Almost packed to go home. Taxi arrives in one and a half hours. Jess is getting her packing done. Justin packed overnight. I thought he was just going to stay up until we left, but he laid down a couple of hours ago. Wont be fun waking him up! ...
Ectopic ACTH syndrome, also known as small-cell carcinoma. Ectopic calcification, a pathologic deposition of calcium salts in ... can cause Cushing's syndrome Ectopia lentis, the displacement of the crystalline lens of the eye Neuronal ectopia Ectopic ... such as at the root of a tooth Ectopic expression, the expression of a gene in an abnormal place in an organism Ectopic hormone ... a testis that has moved to an unusual location Ectopic thymus, where thymus tissue is found in an abnormal location Ectopic ...
If ectopic, the plasma ACTH and cortisol levels should remain unchanged; if this is pituitary related, levels of both would ... This should not be confused with ectopic Cushing syndrome or exogenous steroid use. The symptoms of Cushing's disease are ... This rarely occurs with ectopic corticotropin syndrome and thus is quite useful for distinguishing between the two conditions. ... A more accurate but invasive test used to differentiate pituitary from ectopic or adrenal Cushing's syndrome is inferior ...
... high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. ... "The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome". J. Clin. Invest. 97 (5): 1311-8 ... Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolio B, Grossman AB, Reincke M (1997). "Ectopic ACTH production by a bronchial ... AVPR1b is then responsible for mediating the stimulatory effect of vasopressin on ACTH release. Several G proteins are also ...
... producing a paraneoplastic Cushing's syndrome. Based on his research into paraneoplastic syndromes, he coined the term "ectopic ... He also discovered that certain cancers, especially of the lungs, can secrete ACTH, ... He also described Liddle's syndrome, a genetic syndrome causing high blood pressure. Liddle developed the dexamethasone ...
Equivocal levels of ACTH indicate ectopic or Paraneoplastic Cushing's Syndrome. The sample is usually taken after ... In essence, it tests to see the source of the raised ACTH levels in a patient with diagnosed Cushing's syndrome and high or ... which have been shown to increase ACTH production in active ACTH-producing pituitary tumors. It is used to help identify the ... Therefore, a sample from here showing raised ACTH compared to the periphery suggests that it is a pituitary cause of Cushing's ...
... with ectopic ACTH syndrome and participates in cell migration". Endocrine. 38 (1): 38-47. doi:10.1007/s12020-010-9324-6. PMID ...
... is a cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) ... A more accurate but invasive test used to differentiate pituitary from ectopic or adrenal Cushing's syndrome is inferior ... This should not be confused with ectopic Cushing syndrome or exogenous steroid use.[4] ... Administration of corticotropin releasing hormone (CRH) can differentiate this condition from ectopic ACTH secretion. In a ...
The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome". J. Clin. Invest. 97 (5): 1311-8 ... Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolio B, Grossman AB, Reincke M (1997). „Ectopic ACTH production by a bronchial ... AVPR1B je inicijalno bio opisan kao novi vazopresinski receptor lociran u adenohipofizi, gde on stimuliše ACTH otpuštanje.[1] ... AVPR1B je izražen u visokim nivoima u ACTH-sekretirajućoj adenohipofizi kao i u bronhijalnim karcinoidima[11] odgovornim za ...
... may lead to ectopic production of hormones like ADH and ACTH that may result in paraneoplastic syndromes and Cushing's syndrome ... ACTH) and anti-diuretic hormone (ADH). Ectopic production of large amounts of ADH leads to syndrome of inappropriate ... cell carcinomas will often secrete substances that result in paraneoplastic syndromes such as Lambert-Eaton myasthenic syndrome ... Approximately half of all individuals diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) will eventually be found to have ...
... a diagnosis of ectopic ACTH syndrome is confirmed. ACTH stimulation test Dexamethasone suppression test Metyrapone ... If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of ... the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH ... ACTH)-dependent hypercortisolism. It is used to evaluate ... leads to little or no response in plasma levels of ACTH or ...
... is used for the medical control of hypercortisolism in Cushing's syndrome (ACTH dependent or independent). The aim ... while most ectopic ACTH-producing tumors will not. Pituitary macroadenomas do not always respond to metyrapone. ... ACTH stimulation test Aminoglutethimide Amphenone B Mitotane Young EA, Ribeiro SC, Ye W (June 2007). "Sex Differences in ACTH ... Therefore, if 11-deoxycortisol levels do not rise and remain less than 7 µg/dl (202 nmol/l) and ACTH rises, then it is highly ...
When Cushing's syndrome is due to extra ACTH it is known as ectopic Cushing syndrome. This may be seen in a paraneoplastic ... would be indicative of Cushing's syndrome because an ectopic source of cortisol or ACTH (such as adrenal adenoma) exists which ... Endogenous Cushing's syndrome results from some derangement of the body's own system of secreting cortisol. Normally, ACTH is ... PMC 1436049 . Ectopic Cushing syndrome Archived 2013-10-02 at the Wayback Machine. at A.D.A.M. Medical Encyclopedia, ...
... ectopic ACTH production, or Lambert-Eaton myasthenic syndrome (muscle weakness due to autoantibodies). Tumors in the top of the ... CS1 maint: Extra text: authors list (link) Honnorat, J; Antoine JC (May 2007). "Paraneoplastic neurological syndromes". ... In lung cancer, these phenomena may include hypercalcemia, syndrome of inappropriate antidiuretic hormone (SIADH, abnormally ... which give this tumor an endocrine/paraneoplastic syndrome association. Most cases arise in the larger airways (primary and ...
... ectopic secretion of ACTH resulting in Cushing's syndrome, and hypersecretion of somatotropin-releasing hormone (causing ... Multiple endocrine neoplasia type 1 (MEN-1 syndrome) or Wermer's syndrome is part of a group of disorders, the multiple ... Malignant islet cell tumors due to MEN 1 syndrome often have a more benign course than do sporadically occurring malignant ... Among patients presenting with Zollinger-Ellison syndrome, 20 to 60% have MEN 1. A severe secretory diarrhea can develop and ...
A high dose of dexamethasone exerts negative feedback on pituitary ACTH-producing cells, but not on ectopic ACTH-producing ... If the cortisol levels are unchanged by low- and high-dose dexamethasone, then other causes of Cushing's syndrome must be ... ACTH as measured prior to dosing of dexamethasone Equivocal results should be followed by a corticotropin-releasing hormone ... It is typically used to diagnose Cushing's syndrome. The DST was historically used for diagnosing depression, but by 1988 it ...
... acth syndrome, ectopic MeSH C04.730.713.988 --- zollinger-ellison syndrome MeSH C04.730.856.225 --- lambert-eaton myasthenic ... acth-secreting pituitary adenoma MeSH C04.588.322.609.145.500 --- nelson syndrome MeSH C04.588.322.609.292 --- growth hormone- ... denys-drash syndrome MeSH C04.557.435.595.950 --- wagr syndrome MeSH C04.557.435.600 --- nephroma, mesoblastic MeSH C04.557. ... denys-drash syndrome MeSH C04.588.945.947.535.585.950 --- wagr syndrome MeSH C04.588.945.947.535.790 --- nephroma, mesoblastic ...
Nelson's syndrome (E24.2) Ectopic ACTH syndrome (E24.3) Alcohol-induced pseudo-Cushing's syndrome (E24.4) Other Cushing's ... Tietz syndrome (ILDS E70.358) Hermansky-Pudlak syndrome (ILDS E70.360) Cross syndrome (ILDS E70.380) (E70.8) Other disorders of ... Gilbert's syndrome (E80.5) Crigler-Najjar syndrome (E80.6) Other disorders of bilirubin metabolism Dubin-Johnson syndrome ... type II Hunter syndrome (E76.2) Other mucopolysaccharidoses Sanfilippo syndrome Morquio syndrome (E77) Disorders of ...
ACTH). More than 80% of patients with Cushing's syndrome develop hypertension., which is accompanied by distinct symptoms of ... More commonly, however, tumors cause inessential hypertension by ectopic secretion of hormones involved in normal physiological ... liddle's syndrome (also called pseudoaldosteronism), glucocorticoid remediable aldosteronism Cushing's syndrome - an excessive ... Cushing's syndrome can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic ...
Mutations in TBX1 and CRKL genes are correlated with DiGeorge syndrome, while mutations in GATA3 have also resulted in a ... By seven weeks of gestation, the anterior pituitary is capable of secreting ACTH. Within eight weeks of gestation, somatotroph ... In rare cases this results in functioning ectopic hormone-secreting tumors in the nasopharynx. The functional development of ... respiratory distress syndrome, jaundice, cardiomyopathy, congenital heart disease, and improper organ development. The ...
... is contraindicated in the presence of an intrauterine device, as well as with ectopic pregnancy, adrenal failure, ... in adults with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery ... effect of mifepristone is manifested at doses greater or equal to 4.5 mg/kg by a compensatory increase in ACTH and cortisol. In ... in adults with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery ...
One study showed that 1.5% of women who got pregnant on DMPA had an ectopic pregnancy, the same ectopic rate as women who ... As an agonist of the GR, MPA has glucocorticoid activity, and as a result can cause symptoms of Cushing's syndrome, steroid ... ACTH), and cortisol levels as well as concentrations of sex hormone-binding globulin (SHBG). There is evidence that the ... Although the overall risk of pregnancy and thus ectopic pregnancy is lowered by DMPA, the possibility of an ectopic pregnancy ...
7-Dehydrocholesterol path: Hydrops-ectopic calcification-moth-eaten skeletal dysplasia. *CHILD syndrome ... The glucocorticoids provide a reliable substitute for cortisol, thereby reducing ACTH levels. Reducing ACTH also reduces the ... with consequent hyperplasia of the adrenal cortex and elevation of ACTH levels. ACTH stimulates uptake of cholesterol and ... These clinical features are those of polycystic ovary syndrome (PCOS), and a small percentage of women with PCOS are found to ...
Adrenal cortical hyperactivity Cushing's syndrome Severe liver disease Adrenal cortical insufficiency Addison's disease Drugs: ... Ectopic insulin production from tumors Hereditary fructose intolerance See also[edit]. *Blood glucose monitoring ...
O'Dwyer AM, Sheppard NP (May 1993). "The role of creatine kinase in the diagnosis of neuroleptic malignant syndrome". ... creatine kinase, ectopic expression CKM creatine kinase, muscle, MM-CK CKMT1A, CKMT1B creatine kinase mitochondrial 1; ...
Kirk E, Bottomley C, Bourne T (2013). "Diagnosing ectopic pregnancy and current concepts in the management of pregnancy of ... Frölich's syndrome) treated with low-dose HCG, observed that both lost fat rather than lean (muscle) tissue.[36] He reasoned ... paraneoplastic syndromes, however, it is not known whether this production is a contributing cause, or an effect of ... and in diagnosis of and follow-up care after treatment of ectopic pregnancy. The lack of a visible fetus on vaginal ultrasound ...
IMS is also a robust transaction manager (IMS TM, also known as IMS DC) - one of the "big three" classic transaction managers along with CICS and BEA (now Oracle) Tuxedo. A transaction manager interacts with an end user (connected through VTAM or TCP/IP, including 3270 and Web user interfaces) or another application, processes a business function (such as a banking account withdrawal), and maintains state throughout the process, making sure that the system records the business function correctly to a data store. Thus IMS TM is quite like a Web application, operating through a CGI program (for example), to provide an interface to query or update a database. IMS TM typically uses either IMS DB or DB2 as its backend database. When used alone with DB2 the IMS TM component can be purchased without the IMS DB component.. IMS TM uses a messaging and queuing paradigm. An IMS control program receives a transaction entered from a terminal (or Web browser or other application) and then stores the ...
The health management system (HMS) is an evolutionary medicine regulative process proposed by Nicholas Humphrey in which actuarial assessment of fitness and economic-type cost-benefit analysis determines the body's regulation of its physiology and health. This incorporation of cost-benefit calculations into body regulation provides a science grounded approach to mind-body phenomena such as placebos that are otherwise not explainable by low level, noneconomic, and purely feedback based homeostatic or allostatic theories. Many medical symptoms such as inflammation, fever, pain, sickness behavior, or morning sickness have an evolutionary medicine function of enabling the body to protect, heal or restore itself from injury, infection or other physiological disruption. The deployment of self-treatments have costs as well as benefits with the result that evolution has selected management processes in the brain such that self-treatments are used only when they provide an overall cost-benefit advantage. ...
The International Myeloma Foundation (IMF) is an American non-profit organization serving patients with myeloma, a cancer of plasma cells in the bone marrow. The IMF also provides support and information for family members, caregivers of myeloma patients, physicians and nurses. The organization is dedicated to improving the quality of life for all myeloma patients by focusing on four key areas: research, education, support, and advocacy. Founded in 1990 by Brian Novis, Susie Novis, and Brian G.M. Durie, M.D., IMF is a 501(c)3 resource for both patients and caregivers, offering programs that include educational seminars, a patient hotline, multilingual publications, government advocacy, and a web-based Personal Information Management system for recording care and treatment. The IMF is based in North Hollywood, California, and, according to its 2013 annual report, has a membership of 350,000 people in 140 countries. Its motto is "Improving lives - Finding the cure". The IMF was founded in 1990 by ...
This is considered to be a hybrid between an exocrine and endocrine tumor derived from crypt cells of the appendix. Histologically, it forms clusters of goblet cells containing mucin with a minor admixture of Paneth cells and endocrine cells. The growth pattern is distinctive: typically producing a concentric band of tumor nests interspersed among the muscle and stroma of the appendiceal wall extending up the shaft of the appendix. This makes the lesion difficult to suspect grossly and difficult to measure. Small tumor nests may be camouflaged amongst the muscle or in periappendiceal fat; cytokeratin preparations best demonstrate the tumor cells; mucin stains are also helpful in identifying them. They behave in a more aggressive manner than do classical appendiceal carcinoids. Spread is usually to regional lymph nodes, peritoneum, and particularly the ovary. They do not produce sufficient hormonal substances to cause the carcinoid or other endocrine syndromes. In fact, they more closely ...
... and its subsets LAMB syndrome and NAME syndrome are autosomal dominant conditions comprising myxomas of the heart and skin, hyperpigmentation of the skin (lentiginosis), and endocrine overactivity. It is distinct from Carney's triad. Approximately 7% of all cardiac myxomas are associated with Carney complex. The spotty skin pigmentation and lentigines occur most commonly on the face, especially on the lips, eyelids, conjunctiva and oral mucosa. Cardiac myxomas may lead to embolic strokes and heart failure and may present with fever, joint pain, shortness of breath, diastolic rumble and tumor plop. Myxomas may also occur outside the heart, usually in the skin and breast. Endocrine tumors may manifest as disorders such as Cushing syndrome. The most common endocrine gland manifestation is an ACTH-independent Cushing's syndrome due to primary pigmented nodular adrenocortical disease (PPNAD). The LAMB acronym refers to ...
Shortly after the entry of the United States into the First World War, Cushing was commissioned as a major in the U.S. Army Medical Corps on May 5, 1917. He was director of the U.S. base hospital attached to the British Expeditionary Force in France. Cushing also served as the head of a surgical unit in a French military hospital outside of Paris. During his time at the French military hospital, Cushing experimented with the use of electromagnets to extract fragments of metallic missile shrapnel that were lodged severely within the brain.[8] He was mentioned in a dispatch by Field Marshal Sir Douglas Haig in November 1917.[9] On June 6, 1918, he was promoted to lieutenant colonel and was assigned as senior consultant in neurological surgery for the American Expeditionary Forces in Europe. He attained the rank of Colonel (O-6) on October 23, 1918.[5] In that capacity, he treated Lieutenant Edward Revere Osler, who was fatally wounded during the third battle of Ypres. Lieutenant Osler was the son ...
... (trade name Metopirone) is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-deoxycortisol levels. Metyrapone can be used in the diagnosis of adrenal insufficiency. Metyrapone 30 mg/kg, maximum dose 3000 mg, is administered at midnight usually with a snack. The plasma cortisol and 11-deoxycortisol are measured the next morning between 8:00 and 9:00 am. A plasma cortisol less than 220 nmol/l indicates adequate inhibition of 11β-hydroxylase. In patients with intact Hypothalamo-pituitary-adrenal axis, CRH and ACTH levels rise as a response to the falling cortisol levels. This results in an increase of the steroid precursors in the pathway. Therefore, if 11-deoxycortisol levels do not rise and remain less than 7 µg/dl (202 ...
The American Association of Neurological Surgeons (AANS) is a scientific and educational association focused on advancing the specialty of neurological surgery. The organization has over 8,000 members around the world. Founded in 1931, the AANS was originally known as the Harvey Cushing Society, named for the brain surgery pioneer Harvey Cushing. The creation of the society was spurred initially by R. Glen Spurling and William P. Van Wagenen who, with Cushing, acknowledged the need for a venue in which younger neurosurgeons could exchange ideas on the specialty. Membership to the Society of Neurological Surgeons, the specialty's key organization during this period, was closed to younger men at this time. Spurling and Van Wagenen enlisted the help of Temple Fay and R. Eustace Semmes in the creation of the group, and on May 6, 1932, the Harvey Cushing Society held its first meeting in Boston. Twenty-three people attended, many of whom were Cushing's colleagues and neurosurgical trainees. Other ...
... is an anti-steroid drug marketed under the tradename Cytadren by Novartis around the world. It blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer. It is also used by bodybuilders. Aminoglutethimide is indicated in conjunction with other drugs for the suppression of adrenal function in patients with Cushing's syndrome. It is also a second or third line choice for the treatment of hormone-sensitive (estrogen and progesterone) metastatic breast cancer. Aminoglutethimide is abused by bodybuilders and other steroid users to lower circulating levels of cortisol in the body and prevent muscle loss. Cortisol is catabolic to protein in muscle and effective blockade of P450scc by aminogluthethimide at high doses prevents muscle loss.[citation needed] Its side effects are skin rash, hepatotoxicity, inhibition of cortisol in the human body, and it may also cause ...
While House is at off-track betting, a woman named Anica who is standing next to him has a seizure. House tells the bystanders to call the paramedics and to take her to Princeton-Plainsboro. Foreman thinks she has DIC due to the alcohol in her system, and House thinks that she has Cushing's syndrome. Cameron thinks that Anica is injecting herself with adrenocorticotropic hormone, which causes Cushing's, because she has Münchausen syndrome. In order to prove herself right, she puts antibiotics on a desk in front of Anica with a warning label that says dangerous. Foreman then gets a call that Anica's urine has turned orange, which confirms the Munchausen's diagnosis, because it means Anica took the Antibiotics Cameron had baited her with, despite the warnings. The team is convinced that she has Münchausen's and want to discharge her. House suggests Münchausen's and aplastic anemia, but Foreman will not allow him to do any more tests. Before Anica leaves the hospital, he tells ...
... (1994) is the first in a series of made-for-TV movies for Universal Television's Action Pack based on the popular feature film Midnight Run. Christopher McDonald takes over the role of bounty hunter Jack Walsh, originated in the first film by Robert De Niro. Another Midnight Run was followed by two more made-for-TV sequels, Midnight Runaround and Midnight Run for Your Life. Jack Walsh (McDonald) is hired by bail bondsman Eddie Moscone (Dan Hedaya) to bring in Bernie Abbot (Jeffrey Tambor) and Helen Bishop (Cathy Moriarty), a husband and wife team of con artists. Moscone also brings in rival bounty hunter Marvin Dorfler (Ed O'Ross) to work with Jack, with the agreement that they will split the money; however, both men are planning to double cross each other. Christopher McDonald: Jack Walsh Jeffrey Tambor: Bernie Abbot Cathy Moriarty: Helen Bishop Ed O'Ross: Marvin Dorfler John Fleck: Jerry Geisler Dan Hedaya: Eddie Moscone Sam Shamshak: Lester Weems Midnight Run 2: Another ...
Pierce defeated former WEC contender Brock Larson via unanimous decision in his UFC debut at UFC Fight Night 19.. Pierce was expected to fight Josh Koscheck on January 11, 2010 at UFC Fight Night 20.[3] However, Koscheck instead fought Anthony Johnson at UFC 106[4] and Pierce went on to face Jon Fitch on December 12, 2009 at UFC 107.[5] After losing the first two rounds, Pierce dominated the end of the third round, nearly finishing Fitch. He lost to Fitch via unanimous decision (29-28, 29-28, 29-28).. Pierce was scheduled to face Rob Kimmons on March 21, 2010 at UFC Live: Vera vs. Jones,[6] but Kimmons was forced off the card with an injury. Pierce instead faced UFC newcomer Julio Paulino.[7] Pierce won the fight via unanimous decision (30-27, 30-27, 30-27).. Pierce again fought another UFC newcomer in Amilcar Alves on August 28, 2010 at UFC 118.[8] He won the fight via submission (straight armbar) in the third round.[9]. For the third consecutive time Pierce fought a UFC newcomer in Kenny ...
... is a diagnostic technique that involves laboratory analysis of saliva to identify markers of endocrine, immunologic, inflammatory, infectious, and other types of conditions. Saliva is a useful biological fluid for assaying steroid hormones such as cortisol, genetic material like RNA, proteins such as enzymes and antibodies, and a variety of other substances, including natural metabolites, including saliva nitrite, a biomarker for nitric oxide status (see below for Cardiovascular Disease, Nitric Oxide: a salivary biomarker for cardio-protection). Saliva testing is used to screen for or diagnose numerous conditions and disease states, including Cushing's disease, anovulation, HIV, cancer, parasites, hypogonadism, and allergies. Salivary testing has even been used by the U.S. government to assess circadian rhythm shifts in astronauts before flight and to evaluate hormonal profiles of soldiers undergoing military survival training. Proponents of saliva testing cite its ease of ...
Ectopic ACTH Syndrome. Medical » Syndromes. EAS. Ectopic ACTH Syndrome. Medical. ART. Assisted Reproductive Technologies ...
Thallium-201 Scintigraphy Was Useful in Diagnosing Ectopic ACTH Syndrome Due to Bronchial Carcinoid. (2001) ... Thallium-201 Scintigraphy Was Useful in Diagnosing Ectopic ACTH Syndrome Due to Bronchial Carcinoid (2001) ...
It is an ectopic response that is ACTH-independant. This site provides information and support for people with Cushings or ... GIP-Dependant Cushings Syndrome. This means that genetically, she has cells on her adrenals that are only supposed to be in ... It is an ectopic response that is acth-independant. I am writing this bio because it was very hard to find this disease, and it ... I have a rare form of cushings syndrome called food-dependant cushings syndrome. Sometimes it is referred to as gip-dependant ...
Cushing Syndrome - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical ... Secretion of ACTH by a nonpituitary tumor, such as small cell carcinoma of the lung or a carcinoid tumor (ectopic ACTH syndrome ... Ectopic ACTH syndrome is treated by removing the nonpituitary tumor that is producing the ACTH. However, in some cases, the ... If ACTH is detectable, provocative tests help differentiate Cushing disease from ectopic ACTH syndrome, which is rarer. In ...
Cushing syndrome is caused by prolonged exposure to elevated levels of either endogenous glucocorticoids or exogenous ... Ectopic CRH secretion leading to increased ACTH secretion comprises a very rare group of cases of Cushing syndrome. [4] ... ACTH-dependent Cushing syndrome is characterized by elevated ACTH levels. Elevated ACTH levels are usually due to an anterior ... Ectopic cortisol secretion from a case of ovarian carcinoma has been reported as a cause of ACTH-independent Cushing syndrome. ...
A case of ectopic ACTH syndrome: diagnostic difficulties caused by intermittent hormone secretion. Acta Endocrinol (Copenh). ...
... notably the syndrome of inappropriate antidiuretic hormone (SIADH) and Lambert-Eaton myasthenic syndrome. ... is associated with paraneoplastic syndromes (PNS) in up to 20% of cases, ... Ectopic ACTH syndrome which usually presents as Addisonian-type hyperpigmentation more likely than as Cushing syndrome ( ... notably the syndrome of inappropriate antidiuretic hormone (SIADH) and Lambert-Eaton myasthenic syndrome.. Iyer et al reported ...
Cushing syndrome is caused by prolonged exposure to elevated levels of either endogenous glucocorticoids or exogenous ... test is the most reliable noninvasive method to differentiate pituitary from ectopic ACTH secretion in Cushings syndrome. Clin ... Cushings syndrome secondary to ectopic cortisol production by an ovarian carcinoma. J Clin Endocrinol Metab. 1983 Oct. 57 (4): ... Prognostic factors in ectopic Cushings syndrome due to neuroendocrine tumors: a multicenter study. Eur J Endocrinol. 2017 Apr ...
In the ectopic ACTH syndrome, the ideal treatment of the secreting tumor can rarely be accomplished. In this instance and in ... ACTH), whereas the latter normally is not. As a consequence of this chimera, aldosterone secretion becomes responsive to ACTH ... Warnock DG: Liddle syndrome: An autosomal dominant from of human hypertension. Kidney Int 53: 18 -24, 1998. ... When a defect in renal transport itself is the proximate cause of alkalosis, i.e., Bartter syndrome, other alterations in renal ...
The human CRH test (hCRH test) is used to differentiate Cushings disease (CD) from ectopic ACTH secretion (EAS); to assess ... autonomous cortisol secretion by the adrenal glands; to characterize pseudo-Cushings syndrome (CS) or adrenal insufficiency ( ... basal ACTH levels, an absent or reduced peak ACTH response was able to differentiate adrenal from ACTH-dependent forms. Peak ... Peak ACTH and peak cortisol were higher in CD, and ∆% ACTH and ∆% cortisol were able to differentiate CD from EAS with a ...
Cushing syndrome is the second syndrome caused by carcinoid tumors and is determined by the ectopic production of ACTH ( ... The ectopic secretion of ACTH in cases with Cushing syndrome would be responsible for 10-15% of neurosecretant tumors (24,25). ... Benito-Martinez E, Galeano-Valle F, Gonzalez A, Edgar MA, Oprea-Ilies G, Ioachimescu AG and Pasquel FJ: Ectopic ACTH syndrome ... In patients with neuroendocrine syndrome an ectopic secretion of ACTH was also investigated by dosing the plasmatic levels of ...
Unusual ectopic ACTH syndrome in a patient with orbital neuroendocrine tumor, resulted false-positive outcome of BIPSS:a case ... Prevalence of Signs and Symptoms of Pseudotumor Cerebri Syndrome Before and After Transsphenoidal Surgery for Cushings Disease ... A Whole-Genome Study of a Boy with Pituitary Stalk Interruption Syndrome and His Family.. Wang CZ, Guo LL, Guo QH, Mu YM.Int J ...
Mini-review: pheochromocytomas causing the ectopic ACTH syndrome. *Ballav, C, Naziat, A, Mihai, R, et al. ...
Diagnosis and management of ACTH-dependent Cushings syndrome: comparison of the features in ectopic and pituitary ACTH ... Cushings Syndrome and Cushings Disease - ACTH Secreting Adenoma. Deficiency of ACTH and Cortisol. Deficiency of LH and FSH ( ... Cushings Syndrome/Disease. By Shirley McCartney, Ph.D., Christine Yedinak, D.N.P., and Maria Fleseriu, M.D., F.A.C.E. ... Cushings Syndrome: An Update. By Laurence Katznelson. M.D.. Gonadotroph And Other Clinically Nonfunctioning Pituitary Adenomas ...
Ectopic Cushing syndrome in 2% to 5% of patients. Production of ectopic corticotropin (ACTH) resulting in elevated free ... SCLC is the most common solid tumor to cause paraneoplastic syndromes. Paraneoplastic syndromes are caused by ectopic hormone ... The most common paraneoplastic syndromes include:. *SIADH (syndrome of inappropriate antidiuresis) in 15% to 40% of patients. ... Lambert-Eaton Myasthenic syndrome in 3% of patients. This presents as a weakness of proximal arms and legs, relieved ...
42yo M with Cushings Syndrome 2/2 SCLC producing ectopic ACTH Dr. Sharon Wardlaw , Morning Report , 08/02/2017 , video ...
Small cell (oat cell) ---very aggressive may have ectopic production of ACTH or ADH (paraneoplastic syndrome)-not amenable to ... Adult Respiratory distress syndrome (ARDS) *Produced by diffuse alveolar damage (DAD) Leakage of protein rich fluid into ... Neonatal respiratory distress syndrome (hyaline membrane disease) *Most common cause of respiratory failure of the newborn * ...
Ectopic ACTH-secreting pulmonary neuroendocrine tumors are rare and account for less than 5% of endogenous Cushings syndrome ... This case illustrates that hypercogulability can further aggravate the diagnostic challenges in ectopic ACTH syndrome. We ... Pulmonary emboli may complicate the imaging of the bronchial carcinoid tumor in ectopic ACTH syndrome. ... The source of ectopic ACTH was ultimately localized by a Gallium-DOTATATE scan, which demonstrated increased tracer uptake in a ...
adrenocortical tumor or ectopic ACTH syndrome * disease in which there are higher levels of ACTH and lower levels of cortisol ... steroid biosynthesis enzymes: stimulated by ACTH, rate limiting step in steroid synthesis. ...
... occult ectopic ACTH syndrome, severe hypercortisolism and malignancy related hypercortisolism. ... occult ectopic ACTH syndrome, severe hypercortisolism and malignancy related hypercortisolism. ... These agents have been effective in a limited number of patients with ACTH-dependent Cushings syndrome. Inhibitors of ... These agents have been effective in a limited number of patients with ACTH-dependent Cushings syndrome. Inhibitors of ...
... autoimmune polyglandular syndrome type b see p. Ectopic acth syndrome. For recommendations on the japanese national insurance ... Acth receptors in the ming dynasty, and its conversion to schizophrenia unclear. This distribution is that of healthcare and so ...
Idiopathic bilateral adrenal hyperplasiaConns syndrome : Aldosterone producing adrenal tumourGlucorticoid suppresible ... Ectopic ACTH syndrome. *. Liddles syndrome. *. 11- deoxycorticosterone secreting adrenal tumour. Clinical feature ... Liddle syndrome is a state of aldosterone excess by the presence of early and severe hypertension. ...
Ectopic nature of his ACTH-dependent Cushings syndrome was confirmed by non-suppression with high-dose dexamethasone ... We present the case of a 66-year-old gentleman with ectopic ACTH syndrome from an occult primary tumour with multiple ... Resection of primary tumour is the management of choice in patients with ectopic ACTH syndrome. However, tumours may remain ... Evaluation and management of patients with ectopic ACTH syndrome from an unidentified primary tumour can be very challenging. ...
The causes of Cushings Syndrome are:. • Cushings Disease (65%) • Ectopic ACTH production (15%) • Adrenal adenoma (15%) • ... The endocrine disorder named after him is obviously Cushings Syndrome or Disease. Cushings Syndrome is the state of prolonged ... Polycystic ovarian syndrome (PCOS). *Fibromyalgia (no lab tests can prove this; diagnosis given when they dont know what else ... I still suffer from high cortisol and high ACTH, with the latter pinpointing the source as pituitary. No tumor shows on my MRI ...