ACTH Syndrome, Ectopic: Symptom complex due to ACTH production by non-pituitary neoplasms.Management Information Systems: Systems designed to provide information primarily concerned with the administrative functions associated with the provision and utilization of services; also includes program planning, etc.Paraneoplastic Endocrine Syndromes: Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion.Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)Esthesioneuroblastoma, Olfactory: A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Pain Management: A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.Chemistry, Clinical: The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.Specialization: An occupation limited in scope to a subsection of a broader field.Pathology, Clinical: A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)Medical Laboratory Personnel: Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.Adenoma: A benign epithelial tumor with a glandular organization.Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Pituitary Gland, Anterior: The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Adenoma, Chromophobe: A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.Carcinoma, Islet Cell: A primary malignant neoplasm of the pancreatic ISLET CELLS. Usually it involves the non-INSULIN-producing cell types, the PANCREATIC ALPHA CELLS and the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS) in GLUCAGONOMA and SOMATOSTATINOMA, respectively.Vipoma: A tumor that secretes VASOACTIVE INTESTINAL PEPTIDE, a neuropeptide that causes VASODILATION; relaxation of smooth muscles; watery DIARRHEA; HYPOKALEMIA; and HYPOCHLORHYDRIA. Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. In most cases, Vipomas are located in the PANCREAS but can be found in extrapancreatic sites.Glucagonoma: An almost always malignant GLUCAGON-secreting tumor derived from the PANCREATIC ALPHA CELLS. It is characterized by a distinctive migratory ERYTHEMA; WEIGHT LOSS; STOMATITIS; GLOSSITIS; DIABETES MELLITUS; hypoaminoacidemia; and normochromic normocytic ANEMIA.Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.Adenoma, Islet Cell: A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Neuroendocrine Tumors: Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Somatostatin: A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
(1/112) Severe muscle weakness due to hypokalemia as a manifestation of small-cell carcinoma.

We describe the case of a 56-year-old man with severe muscle weakness due to heavy hypokalemia (serum potassium 1.44 mmol/l) associated with inappropriate kaliuria and alkalemia. Subsequent investigation revealed the presence of ectopic ACTH hypersecretion due to a small-cell lung carcinoma. A significant clinical/laboratory improvement was achieved following chemotherapy-induced regression of the primary tumor. The profound hypokalemia was probably the result of cortisol hypersecretion, which in concert with the ACTH-induced decreased 11beta-hydroxysteroid dehydrogenase activity can exhibit an increased mineralocorticoid activity. In addition, other ACTH-dependent mineralocorticoids may play a contributory role in the development of severe hypokalemia.  (+info)

(2/112) Carcinoid-associated ectopic ACTH syndrome with variable response to octreotide.

The case is presented of a 31-year-old woman who developed florid clinical and biochemical Cushing's syndrome due to metastatic hepatic carcinoid tumour from a probable pancreatic primary. Hypercortisolaemia was controlled with metyrapone and ketoconazole, but high doses of octreotide failed to affect plasma cortisol and urinary 5-hydroxyindole acetic acid (5HIAA) levels, or prevent rapid tumour growth. Hepatic polystyrene embolisation failed, and she was treated by liver transplantation with initial excellent results, and normalisation of cortisol and 5HIAA levels. Ten months later, however, she relapsed with bony and pelvic tumour recurrence, and high and symptomatic levels of cortisol and 5HIAA. At this time, octreotide in similar doses to those used previously appeared to normalise her biochemically, although she died soon after. This variable responsiveness to octreotide could be related to somatostatin receptor changes, or cyclical tumour secretion patterns.  (+info)

(3/112) Marked increase in plasma ACTH with tumor reduction after chemotherapy in ectopic ACTH syndrome.

We report on a case of rapid and marked hormone release as a result of rapid tumor reduction due to chemotherapy in a 36-year-old woman with ectopic ACTH syndrome due to small cell lung cancer. Treatment of the cancer with cisplatin and etoposide resulted in an 80% reduction in tumor size on computed tomographic scan within two weeks. Concurrently, plasma ACTH exhibited an unexpected and astonishing increase from 373 pg/ml before treatment to more than 1200 pg/ml. There were no biochemical characteristics observed in tumor lysis syndrome of solid tumors such as azotemia, increased LDH and hyperkalemia. The present case indicates that anticancer chemotherapy instituted in patients with ectopic ACTH syndrome could result in an acute increase of plasma ACTH and exacerbation of hypercortisolism, similar to tumor lysis syndrome, which is a potentially fatal complication following anti-cancer chemotherapy.  (+info)

(4/112) Is whole-lung CT scanning still necessary in all cases of ACTH-dependent Cushing's syndrome in the era of petrosal sinus sampling?

We reviewed 31 patients in whom both bilateral inferior petrosal sinus sampling without CRH stimulation, and a CT scan of the lungs were done. Twenty-five had normal lung CT scans, of whom 23 had a higher inferior petrosal sinus: peripheral ACTH ratio > or = 1.5. After careful follow-up, none was subsequently shown to have ectopic ACTH syndrome. Six had abnormal lung CT scans, of whom two had ratios > or = 1.5. In these two patients, other investigations suggested pituitary disease, and pituitary surgery led to apparent cure. Of the remaining four patients, who had ratios < 1.5, two had incidental lung findings, and pituitary abnormalities were demonstrated at pituitary surgery. The third underwent bilateral adrenalectomy, and no evidence of ectopic ACTH syndrome has emerged as yet after 4 years follow-up. The fourth had a small-cell carcinoma of the lung, confirmed histologically. Our series suggests that whole-lung CT scanning is only necessary in cases of ACTH-dependent Cushing's syndrome where bilateral inferior petrosal sinus sampling has not demonstrated a significant increase in petrosal sinus ACTH levels as compared with the peripheral level. Thus, in our experience the test is now only necessary in those patients (approximately 25%) where the ratio is < or = 1.5.  (+info)

(5/112) Thymic hyperplasia as a source of ectopic ACTH production.

A 26 year-old man with suspected Cushing's disease underwent transsphenoidal exploration of the pituitary without any evidence of microadenoma or hyperplasia. Progressive hypercortisolism necessitated bilateral adrenalectomy. Postoperatively, skin pigmentation gradually developed with a marked elevation of plasma ACTH levels, and CT scanning uncovered a thymic mass. Following removal of the thymic mass, skin pigmentation disappeared and plasma ACTH levels fell to normal. The excised mass was found to be a benign thymic hyperplasia without epithelial or carcinoid tumor cells. However, gel chromatography showed that the thymic tissue extract contained high ACTH content comparable to that of ectopic ACTH-producing tumors with a major component corresponding to ACTH(1-39). Northern blot analysis and in situ hybridization revealed the expression of proopiomelanocortin transcripts in lymphocytes of thymic hyperplasia. This report suggests that lymphocytes in thymic hyperplasia are the most likely site of deregulated ACTH expression causing ectopic ACTH syndrome.  (+info)

(6/112) Clinical implications of glucocorticoid metabolism by 11beta-hydroxysteroid dehydrogenases in target tissues.

11beta-Hydroxysteroid dehydrogenases (11beta-HSD) are microsomal enzymes that catalyze the conversion of active glucocorticoids (GC) to their inactive 11-dehydro products and vice versa. Two isoenzymes of 11beta-HSD have been characterized and cloned in human tissues. The tissue-specific metabolism of GC by these enzymes is important for mineralocorticoid (MC) and GC receptor occupancy and seems to play a crucial role in the pathogenesis of diseases such as apparent MC excess syndrome, and may play roles in hypertension, obesity and impaired hepatic glucose homeostasis. This article reviews the literature and examines the role and importance of 11beta-HSD in humans.  (+info)

(7/112) A new generation IRMA for ACTH with improved specificity: validation in various physiological and pathological conditions.

OBJECTIVE: Measurement of plasma ACTH is a key step for the exploration of hypothalamic-pituitary-adrenal disorders. To further improve ACTH recognition a new generation of ACTH IRMA was developed using antibodies directed towards succinylated ACTH (sACTH IRMA). DESIGN: The usefulness of this assay was compared with that of another commercially available ACTH IRMA assay using intact ACTH (ELSA-ACTH) in various pathophysiological situations: patients with low ACTH plasma levels, high ACTH plasma levels with normal or tumoural pituitaries, or ectopic ACTH syndrome, and pregnant women with high proopiomelanocortin (POMC) plasma levels. METHODS: All plasma samples were assayed simultaneously with the two different IRMAs. Comparisons were assessed by plotting the results along the theoretical line of identical values, and by the graphical method of Bland and Altman. RESULTS: In the ELSA-ACTH IRMA, CLIP (or ACTH18-39) showed true cross-reactivity, and alpha-melanocyte-stimulating hormone and purified POMC both interfered and induced falsely lower ACTH results; in the sACTH IRMA no peptide showed any cross-reactivity, and only extremely high values of CLIP (50 000 pg/ml) interfered and induced falsely lower ACTH results. In ACTH hypersecretory syndromes, of tumoural (Cushing's disease, ectopic ACTH secretion) or non-tumoural (Addison's disease, congenital adrenal hyperplasia) origins a good agreement between the two assays was observed except for very high ACTH plasma values (above 1000 pg/ml) and in some tumours where the sACTH IRMA yielded lower results; in some cases, the presence of circulating CLIP, demonstrated by HPLC studies, may contribute to this discrepancy. It is also likely that the calibration of the ELSA-ACTH kit itself generates higher ACTH values. In normal pregnant women both IRMAs gave highly correlated values, yet lower results were obtained with the sACTH IRMA. CONCLUSION: These data show that the sACTH IRMA has improved qualities of specificity and usefulness for rapid assessment of ACTH plasma levels.  (+info)

(8/112) Ectopic adrenocorticotropin syndrome exhibiting paradoxical adrenocorticotropin responsiveness to gonadotropin-releasing hormone.

In a 37-year-old man who had Cushing's syndrome, investigations, including overnight dexamethasone suppression test, corticotropin-releasing hormone (CRH) test, pituitary MRI and inferior petrosal sinus sampling suggested the presence of ectopic adrenocorticotropin (ACTH) production. Interestingly, gonadotropin-releasing hormone (GnRH) increased plasma ACTH from 73 pg/ml to 708 pg/ml at 15 min. Furthermore, desmopressin also increased plasma ACTH whereas CRH and thyrotropin-releasing hormone (TRH) had no effect. Such paradoxical responses of plasma ACTH were observed repeatedly. A thoracic CT scan revealed a right anterior mediastinal mass, which was surgically resected. Histological and immunohistochemical examination confirmed that the tumor was an ACTH-producing carcinoid. ACTH and cortisol decreased immediately following surgery. Neither desmopressin nor GnRH administration resulted in elevation of plasma ACTH while ACTH-responsiveness to dexamethasone and CRH was restored. To our knowledge, this is the first report documenting GnRH responsiveness in ectopic ACTH syndrome.  (+info)

*  Ectopia (medicine)
Ectopic ACTH syndrome, also known as small-cell carcinoma. Ectopic calcification, a pathologic deposition of calcium salts in ... can cause Cushing's syndrome Ectopia lentis, the displacement of the crystalline lens of the eye Neuronal ectopia Ectopic ... such as at the root of a tooth Ectopic expression, the expression of a gene in an abnormal place in an organism Ectopic hormone ... a testis that has moved to an unusual location Ectopic thymus, where thymus tissue is found in an abnormal location Ectopic ...
*  Vasopressin receptor 1B
... high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. ... "The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome". J. Clin. Invest. 97 (5): 1311-8 ... Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolio B, Grossman AB, Reincke M (1997). "Ectopic ACTH production by a bronchial ... AVPR1b is then responsible for mediating the stimulatory effect of vasopressin on ACTH release. Several G proteins are also ...
*  PAK3
... with ectopic ACTH syndrome and participates in cell migration". Endocrine. 38 (1): 38-47. doi:10.1007/s12020-010-9324-6. PMID ...
*  Corticorelin
... a diagnosis of ectopic ACTH syndrome is confirmed. ACTH stimulation test Dexamethasone suppression test Metyrapone ... If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of ... the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH ... ACTH)-dependent hypercortisolism. It is used to evaluate ... leads to little or no response in plasma levels of ACTH or ...
*  Inferior petrosal sinus sampling
Equivocal levels of ACTH indicate ectopic or Paraneoplastic Cushing's Syndrome. The sample is usually taken after ... In essence, it tests to see the source of the raised ACTH levels in a patient with diagnosed Cushing's syndrome and high or ... which have been shown to increase ACTH production in active ACTH-producing pituitary tumors. It is used to help identify the ... Therefore, a sample from here showing raised ACTH compared to the periphery suggests that it is a pituitary cause of Cushing's ...
*  Cushing's disease
If ectopic, the plasma ACTH and cortisol levels should remain unchanged; if this is pituitary related, levels of both would ... This should not be confused with ectopic Cushing syndrome or exogenous steroid use. The symptoms of Cushing's disease are ... This rarely occurs with ectopic corticotropin syndrome and thus is quite useful for distinguishing between the two conditions. ... A more accurate but invasive test used to differentiate pituitary from ectopic or adrenal Cushing's syndrome is inferior ...
*  ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases
Nelson's syndrome (E24.2) Ectopic ACTH syndrome (E24.3) Alcohol-induced pseudo-Cushing's syndrome (E24.4) Other Cushing's ... Tietz syndrome (ILDS E70.358) Hermansky-Pudlak syndrome (ILDS E70.360) Cross syndrome (ILDS E70.380) (E70.8) Other disorders of ... Gilbert's syndrome (E80.5) Crigler-Najjar syndrome (E80.6) Other disorders of bilirubin metabolism Dubin-Johnson syndrome ... type II Hunter syndrome (E76.2) Other mucopolysaccharidoses Sanfilippo syndrome Morquio syndrome (E77) Disorders of ...
*  Cushing's syndrome
When Cushing's syndrome is due to extra ACTH it is known as ectopic Cushing syndrome. This may be seen in a paraneoplastic ... would be indicative of Cushing's syndrome because an ectopic source of cortisol or ACTH (such as adrenal adenoma) exists which ... Endogenous Cushing's syndrome results from some derangement of the body's own system of secreting cortisol. Normally, ACTH is ... PMC 1436049 . Ectopic Cushing syndrome Archived 2013-10-02 at the Wayback Machine. at A.D.A.M. Medical Encyclopedia, ...
*  Lung cancer
... ectopic ACTH production, or Lambert-Eaton myasthenic syndrome (muscle weakness due to autoantibodies). Tumors in the top of the ... CS1 maint: Extra text: authors list (link) Honnorat, J; Antoine JC (May 2007). "Paraneoplastic neurological syndromes". ... In lung cancer, these phenomena may include hypercalcemia, syndrome of inappropriate antidiuretic hormone (SIADH, abnormally ... which give this tumor an endocrine/paraneoplastic syndrome association. Most cases arise in the larger airways (primary and ...
*  Multiple endocrine neoplasia type 1
... ectopic secretion of ACTH resulting in Cushing's syndrome, and hypersecretion of somatotropin-releasing hormone (causing ... Multiple endocrine neoplasia type 1 (MEN-1 syndrome) or Wermer's syndrome is part of a group of disorders, the multiple ... Malignant islet cell tumors due to MEN 1 syndrome often have a more benign course than do sporadically occurring malignant ... Among patients presenting with Zollinger-Ellison syndrome, 20 to 60% have MEN 1. A severe secretory diarrhea can develop and ...
*  Small-cell carcinoma
... may lead to ectopic production of hormones like ADH and ACTH that may result in paraneoplastic syndromes and Cushing's syndrome ... ACTH) and anti-diuretic hormone (ADH). Ectopic production of large amounts of ADH leads to syndrome of inappropriate ... cell carcinomas will often secrete substances that result in paraneoplastic syndromes such as Lambert-Eaton myasthenic syndrome ... Approximately half of all individuals diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) will eventually be found to have ...
*  Grant Liddle
... producing a paraneoplastic Cushing's syndrome. Based on his research into paraneoplastic syndromes, he coined the term "ectopic ... He also discovered that certain cancers, especially of the lungs, can secrete ACTH, ... He also described Liddle's syndrome, a genetic syndrome causing high blood pressure. Liddle developed the dexamethasone ...
*  Metyrapone
... is used for the medical control of hypercortisolism in Cushing's syndrome (ACTH dependent or independent). The aim ... while most ectopic ACTH-producing tumors will not. Pituitary macroadenomas do not always respond to metyrapone. ... ACTH stimulation test Aminoglutethimide Amphenone B Mitotane Young EA, Ribeiro SC, Ye W (June 2007). "Sex Differences in ACTH ... Therefore, if 11-deoxycortisol levels do not rise and remain less than 7 µg/dl (202 nmol/l) and ACTH rises, then it is highly ...
*  List of MeSH codes (C04)
... acth syndrome, ectopic MeSH C04.730.713.988 --- zollinger-ellison syndrome MeSH C04.730.856.225 --- lambert-eaton myasthenic ... acth-secreting pituitary adenoma MeSH C04.588.322.609.145.500 --- nelson syndrome MeSH C04.588.322.609.292 --- growth hormone- ... denys-drash syndrome MeSH C04.557.435.595.950 --- wagr syndrome MeSH C04.557.435.600 --- nephroma, mesoblastic MeSH C04.557. ... denys-drash syndrome MeSH C04.588.945.947.535.585.950 --- wagr syndrome MeSH C04.588.945.947.535.790 --- nephroma, mesoblastic ...
*  Dexamethasone suppression test
A high dose of dexamethasone exerts negative feedback on pituitary ACTH-producing cells, but not on ectopic ACTH-producing ... If the cortisol levels are unchanged by low- and high-dose dexamethasone, then other causes of Cushing's syndrome must be ... ACTH as measured prior to dosing of dexamethasone Equivocal results should be followed by a corticotropin-releasing hormone ... It is typically used to diagnose Cushing's syndrome. The DST was historically used for diagnosing depression, but by 1988 it ...
*  Secondary hypertension
ACTH). More than 80% of patients with Cushing's syndrome develop hypertension., which is accompanied by distinct symptoms of ... More commonly, however, tumors cause inessential hypertension by ectopic secretion of hormones involved in normal physiological ... liddle's syndrome (also called pseudoaldosteronism), glucocorticoid remediable aldosteronism Cushing's syndrome - an excessive ... Cushing's syndrome can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic ...
*  Development of the endocrine system
Mutations in TBX1 and CRKL genes are correlated with DiGeorge syndrome, while mutations in GATA3 have also resulted in a ... By seven weeks of gestation, the anterior pituitary is capable of secreting ACTH. Within eight weeks of gestation, somatotroph ... In rare cases this results in functioning ectopic hormone-secreting tumors in the nasopharynx. The functional development of ... respiratory distress syndrome, jaundice, cardiomyopathy, congenital heart disease, and improper organ development. The ...
*  Mifepristone
... is contraindicated in the presence of an intrauterine device, as well as with ectopic pregnancy, adrenal failure, ... in adults with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery ... effect of mifepristone is manifested at doses greater or equal to 4.5 mg/kg by a compensatory increase in ACTH and cortisol. In ... in adults with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery ...
*  Medroxyprogesterone acetate
One study showed that 1.5% of women who got pregnant on DMPA had an ectopic pregnancy, the same ectopic rate as women who ... As an agonist of the GR, MPA has glucocorticoid activity, and as a result can cause symptoms of Cushing's syndrome, steroid ... ACTH), and cortisol levels as well as concentrations of sex hormone-binding globulin (SHBG). There is evidence that the ... Although the overall risk of pregnancy and thus ectopic pregnancy is lowered by DMPA, the possibility of an ectopic pregnancy ...
Ectopic ACTH syndrome (EAS)  Ectopic ACTH syndrome (EAS)
... is caused by nonpituitary tumors that secrete either adrenocorticotropic hormone (ACTH) and/or ... RIAs are recommended for investigating ectopic ACTH-producing tumors, because some of the tumors secrete ACTH precursors and ... In ACTH independent tumors (Adrenal), plasma ACTH levels are very low to undetectable. Conversely, in ACTH dependent tumors ( ... particularly to separate ACTH dependent from ACTH independent causes. ACTH is a polypeptide hormone that exists principally as ...
more infohttps://www.clinicalpainadvisor.com/labmed/ectopic-acth-syndrome-eas/article/614220/
2019 ICD-10-CM Diagnosis Code E24.3: Ectopic ACTH syndrome  2019 ICD-10-CM Diagnosis Code E24.3: Ectopic ACTH syndrome
Ectopic ACTH syndrome. 2016 2017 2018 2019 Billable/Specific Code *E24.3 is a billable/specific ICD-10-CM code that can be used ... Ectopic hormone secretion, not elsewhere classified. 2016 2017 2018 2019 Billable/Specific Code Type 1 Excludes*ectopic ACTH ... Cushing's syndrome. 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes*congenital adrenal hyperplasia (E25.0) ... Symptom complex due to acth production by non-pituitary neoplasms.. ICD-10-CM E24.3 is grouped within Diagnostic Related Group( ...
more infohttps://www.icd10data.com/ICD10CM/Codes/E00-E89/E20-E35/E24-/E24.3
Ectopic ACTH syndrome (EAS) - Cancer Therapy Advisor  Ectopic ACTH syndrome (EAS) - Cancer Therapy Advisor
Ectopic ACTH syndrome (EAS) is caused by nonpituitary tumors that secrete either adrenocorticotropic hormone (ACTH) and/or ... RIAs are recommended for investigating ectopic ACTH-producing tumors, because some of the tumors secrete ACTH precursors and ... In ACTH independent tumors (Adrenal), plasma ACTH levels are very low to undetectable. Conversely, in ACTH dependent tumors ( ... particularly to separate ACTH dependent from ACTH independent causes. ACTH is a polypeptide hormone that exists principally as ...
more infohttp://www.cancertherapyadvisor.com/labmed/ectopic-acth-syndrome-eas/article/614214/
Ectopic ACTH syndrome - MediGoo - Medical Tests | Medical Information  Ectopic ACTH syndrome - MediGoo - Medical Tests | Medical Information
... of all cases of ACTH-dependent hypercortisolism. Different from Cushing's, in the female sex. ... Ectopic ACTH syndrome: Description, Causes and Risk Factors:Abbreviation: EAS.The ectopic ACTH syndrome was ?rst described in ... The term `ectopic ACTH syndrome' is considered a misnomer by some authors, since many non-neoplasic tissues produce ACTH. ... Optimal treatment for ectopic ACTH syndrome is dependent on the ability to localize the source of ACTH. Surgical resection of ...
more infohttps://www.medigoo.com/articles/ectopic-acth-syndrome/?aelia_cs_currency=CAD
Ectopic ACTH syndrome: our experience with 25 cases in: European Journal of Endocrinology Volume 155 Issue 5 Year 2006  Ectopic ACTH syndrome: our experience with 25 cases in: European Journal of Endocrinology Volume 155 Issue 5 Year 2006
ACTH)-dependent Cushing's syndrome: early recognition of the occult ectopic ACTH syndrome. Journal of Clinical Endocrinology ... ACTH)-dependent Cushing's syndrome: early recognition of the occult ectopic ACTH syndrome. Journal of Clinical Endocrinology ... who described a patient with thymus cancer and ectopic ACTH secretion (1, 2). The term 'ectopic ACTH syndrome' is considered a ... Ectopic ACTH syndrome and CRH-mediated Cushing's syndrome. Endocrinology and Metabolism Clinics of North America199423585-606. ...
more infohttps://eje.bioscientifica.com/abstract/journals/eje/155/5/1550725.xml
Ectopic Cushings syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum | ECE2010  Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum | ECE2010
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. Joerg Singer1, ... Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum (. ... Ectopic ACTH secretion within the small bowel is very rare. This case accentuates the difficulty in locating the source of ... Further examinations revealed ectopic Cushing s syndrome. The search for the location of the primary tumor proved to be ...
more infohttp://www.endocrine-abstracts.org/ea/0022/ea0022p429.htm
Adrenocortical Carcinoma (ACC) - Clinical Advisor  Adrenocortical Carcinoma (ACC) - Clinical Advisor
Ectopic ACTH syndrome (EAS) Back to Top *. table td {border-collapse:collapse;border-style:none !important;}td {padding: 3px ... ACTH acutely stimulates the secretion of DHEA but not DHEA-S. Extremely high levels (,700 or 800 ug/dL) in women are suggestive ... DHEA is secreted by the adrenal gland, and production is, at least partly, controlled by ACTH. The bulk of DHEA is secreted as ... Most ACC cases are sporadic in nature, but some have been described as a component of severe hereditary cancer syndromes:. Li- ...
more infohttps://www.clinicaladvisor.com/home/decision-support-in-medicine/labmed/adrenocortical-carcinoma-acc/
Cushings disease in animals | Long Beach Animal Hospital  Cushing's disease in animals | Long Beach Animal Hospital
Ectopic ACTH Syndrome. This is a rare version of Cushing's that does not fall into any of the above categories. It can be found ... A blood sample is taken to measure the resting cortisol level before ACTH is given. Two hours after the ACTH injection is given ... ACTH). It is the amount of ACTH circulating in the blood stream that tells the adrenal glands (specifically, the cells at the ... causing them to secrete less ACTH. Less ACTH in the bloodstream will cause the other adrenal (if it does not also have a tumor ...
more infohttp://www.lbah.com/word/canine/cushings-hyperadrenocorticism/
Skin Conditions  Skin Conditions
Ectopic ACTH Syndrome. This is a rare version of Cushing's that does not fall into any of the above categories. It can be found ... A blood sample is taken to measure the resting cortisol level before ACTH is given. Two hours after the ACTH injection is given ... ACTH). It is the amount of ACTH circulating in the blood stream that tells the adrenal glands (specifically, the cells at the ... causing them to secrete less ACTH. Less ACTH in the bloodstream will cause the other adrenal (if it does not also have a tumor ...
more infohttps://www.lbah.com/category/canine/skin/
Cushings Syndrome/Disease - Causes, Symptoms, Diagnosis and Treatments  Cushing's Syndrome/Disease - Causes, Symptoms, Diagnosis and Treatments
Learn about Cushing's Syndrome and Disease, including treatment options, with information provided by board-certified ... Ectopic ACTH Syndrome Some benign or malignant (cancerous) tumors that arise outside the pituitary gland can produce ACTH. This ... ectopic Cushing's syndrome) or a tumor of the pituitary gland secreting adrenocorticotropic hormone (ACTH) which stimulates the ... condition is known as ectopic ACTH syndrome. Lung tumors (malignant adenomas or carcinoids) cause more than 50 percent of these ...
more infohttps://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Cushings-Disease
Surgery1 Flashcards by Hassan Nabi | Brainscape  Surgery1 Flashcards by Hassan Nabi | Brainscape
ectopic ACTH Syndrome. • MEN. • cushing syndrome. • addison disease cushing syndrome 7 what is important in cushing syndrome? ... O2 is indicated for the treatment of all types of syncope except for hyperventilation syndrome.. • Monitor vital signs and ...
more infohttps://www.brainscape.com/flashcards/surgery1-3598315/packs/5399683
Cushings Syndrome | SpringerLink  Cushing's Syndrome | SpringerLink
1995) Ectopic ACTH syndrome. J Steroid Biochem Mol Biol 53:139-51CrossRefPubMedGoogle Scholar ... Ilias I, Nieman LK (2002) Cushing syndrome due to ectopic ACTH secretion: two decades' experience at a single center. The ... 2002) Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 ... 2002) Single determination of plasma ACTH using an immunoradiometric assay with high detectability differentiates between ACTH- ...
more infohttps://link.springer.com/chapter/10.1007/3-540-26861-8_6
Search of: familial isolated pituitary adenoma OR Pituitary Neoplasms - List Results - ClinicalTrials.gov  Search of: 'familial isolated pituitary adenoma' OR 'Pituitary Neoplasms' - List Results - ClinicalTrials.gov
Nelson Syndrome. *Ectopic ACTH Syndrome. *Drug: pasireotide LAR. Interventional. Phase 2. *Novartis Pharmaceuticals ... To assess the accuracy and sensitivity of 18F-FDG high-resolution PET-imaging detection of ACTH-adenomas in CD compared to MR- ... To determine effect of CRH stimulation on 18F-FDG uptake in high-resolution PET-imaging of ACTH-adenomas in CD. ... Rosiglitazone in Treating Patients With Newly Diagnosed ACTH-Secreting Pituitary Tumor (Cushing Disease). *Cushing's ...
more infohttps://clinicaltrials.gov/ct2/results?cond=%22familial+isolated+pituitary+adenoma%22+OR+%22Pituitary+Neoplasms%22&show_flds=Y
Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin - Full Text View - ClinicalTrials.gov  Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin - Full Text View - ClinicalTrials.gov
Nelson's Syndrome. Pancreatic neoplasm. pituitary neoplasm. Nelson Syndrome. ectopic ACTH syndrome. pasireotide LAR. PNETs. ... Nelson Syndrome. ACTH Syndrome, Ectopic. Cushing Syndrome. Disease. Pathologic Processes. Hypothalamic Diseases. Brain Diseases ... Pancreatic Neoplasm Pituitary Neoplasm Nelson Syndrome Ectopic ACTH Syndrome Drug: pasireotide LAR Phase 2 ... Genetic and Rare Diseases Information Center resources: Cushing's Syndrome Nelson Syndrome ACTH-secreting Pituitary ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00958841
Original Drugstore: Diflucan for men no prescription  Original Drugstore: Diflucan for men no prescription
Ectopic acth syndrome %. Ectopic crh production has been documented. You must follow a clearly depressive nature. Cri du chat ...
more infohttp://www.nationalautismcenter.org/resources/diflucan-for-men-no-prescription-12377/33/
Ectopic Cushing syndrome | Multimedia Encyclopedia | Health Information | St. Lukes Hospital  Ectopic Cushing syndrome | Multimedia Encyclopedia | Health Information | St. Luke's Hospital
Ectopic Cushing syndrome is caused by tumors that release ACTH. Tumors that can, in rare cases, release ACTH include: Tumors. A ... Ectopic Cushing syndrome, on the other hand, occurs when ACTH is produced somewhere other than the pituitary gland. Ectopic ... Ectopic Cushing syndrome tends to have fewer symptoms than classic Cushing syndrome. Most people with Cushing syndrome have:. * ... Ectopic Cushing syndrome. Cushing syndrome - ectopic; Ectopic ACTH syndrome Ectopic Cushing syndrome is a form of Cushing ...
more infohttps://www.stlukes-stl.com/health-content/health-ency-multimedia/1/000406.htm
Download The Very Thought Of Education: Psychoanalysis And The Impossible Professions  Download The Very Thought Of Education: Psychoanalysis And The Impossible Professions
Ectopic ACTH Syndrome; possible small Hormone Syndrome), from the contributions to the most medial binaries of server. The ... Adrenal Hyperfunction happening from Pituitary ACTH Excess; Cushing's III; ...
more infohttp://www.autoshop101.com/trainmodules/batservice/image/pdf/download-The-Very-Thought-of-Education%3A-Psychoanalysis-and-the-Impossible-Professions/
Pancreas symptoms - RightDiagnosis.com  Pancreas symptoms - RightDiagnosis.com
Ectopic ACTH Syndrome ... diabetes*Erdheim-Chester Disease ... Diabetes insipidus*Erdheim-Chester syndrome ... diabetes ... Metabolic syndrome often undiagnosed: Metabolic syndrome, also known as Syndrome X, is an often overlooked medical condition ... Bard-Pic syndrome ... hyperglycemia*Bruns-Garland syndrome ... diabetes*Brunzell syndrome ... hyperglycemia. C. *Carcinoid ... MODY syndrome, type 1 ... hyperglycemia*MODY syndrome, type 2 ... glucosuria*MODY syndrome, type III ... hyperglycemia*MODY ...
more infohttps://www.rightdiagnosis.com/sym/pancreas_symptoms.htm
Endokrine paraneoplastische Syndrome | SpringerLink  Endokrine paraneoplastische Syndrome | SpringerLink
Endokrine paraneoplastische Syndrome sind die Folge der Sekretion bioaktiver Substanzen aus neoplastischen Zellen endokrinen ... Alexandraki KI, Grossman AB (2010) The ectopic ACTH syndrome. Rev Endocr Metab Disord 11:117-126CrossRefPubMedGoogle Scholar ... Inappropriate ADH syndrome Cushing syndrome Acromegaly Hormones, ectopic Positron emission tomography computed tomography ... Prevalence and clinical features of the ectopic ACTH syndrome in patients with gastroenteropancreatic and thoracic ...
more infohttps://link.springer.com/article/10.1007%2Fs41969-018-0049-0
  • For example, polycystic ovary syndrome can cause menstrual disturbances, weight gain beginning in adolescence, excess hair growth, and impaired insulin action and diabetes. (cushings.org)
  • Details and Download Full Text PDF: Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour. (pubfacts.com)
  • In summary, ACTH-producing pheochromocytoma is a rare condition that poses a clinical challenge in the perioperative period. (deepdyve.com)
  • Abdominal examination for tenderness - e.g. tenderness in epigastric area (midline below ribs) may suggest acute or chronic pancreatitis, peptic ulceration of Zollinger-Ellison syndrome, cancer of the pancreas. (rightdiagnosis.com)
  • The metyrapone test, which can be done in 48 hours, has a sensitivity and specificity for the diagnosis of the Cushing syndrome identical to that of the standard 6-day high-dose dexamethasone suppression test. (annals.org)
  • The probability of success was a chance that the true responder rate was greater than 15%) for the indications gastrinoma, prolactinoma, and Nelson's syndrome. (clinicaltrials.gov)
  • When the adrenals, which are located just above the kidneys, receive the ACTH, they respond by releasing cortisol into the bloodstream. (cushings.org)
  • The carcinoid syndrome is rare but it is associated with carcinoid heart disease in more than a half of the cases. (pubfacts.com)
  • Ectopic calcification, a pathologic deposition of calcium salts in tissues or bone growth in soft tissues Cerebellar tonsillar ectopia, aka Chiari malformation, a herniation of the brain through the foramen magnum, which may be congenital or caused by trauma. (wikipedia.org)