A rare cutaneous tumor of eccrine sweat gland origin. It is most commonly found on the extremities and is usually benign. There is no indication that heredity or external agents cause these tumors.

Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. (1/8)

BACKGROUND: Eccrine porocarcinoma is an uncommon neoplasm of the intra-epidermal sweat gland duct. PATIENTS AND METHODS: A case of eccrine porocarcinoma in a female renal transplant patient aged 45 years is described with a review of pertinent literature. RESULTS: The primary tumour was highly pleomorphic. In places large and small cells merged and focally the former component infiltrated the epidermis in a manner akin to Paget's disease of the breast. The majority of the tumour was high grade; using the modified Bloom and Richardson grading system, usually applied to mammary ductal carcinomas, the tumour graded as 3. Metastatic disease developed nine months following primary surgical treatment. The metastatic eccrine porocarcinoma was resistant to epirubicin but responded to docetaxel chemotherapy. CONCLUSIONS: There are no data to support the use of adjuvant therapy in the management of eccrine porocarcinoma. The use of the modified Bloom and Richardson grading system may define cases at high risk of relapse in which adjuvant therapy might be considered. Metastatic eccrine porocarcinoma has proven resistant to many chemotherapeutic agents. We report the first use of docetaxel in the management of this disease. The treatment was well tolerated and resulted in marked symptomatic and radiological responses. Treatment with docetaxel should be considered in future cases of this rare tumour.  (+info)

Eccrine porocarcinoma (malignant eccrine poroma): a case report. (2/8)

Eccrine porocarcinoma is a rare malignancy of eccrine sweat gland usually presenting as a long-standing growth on the lower extremity. It is more common in females. It may arise in a pre-existing eccrine poroma. A case presenting as nodular swelling over the dorsum of left hand in a 56-year-old man is described. Cytologic and histologic examination along with flow cytometric analysis is presented.  (+info)

Eccrine porocarcinoma. (3/8)

We present an unusual case of eccrine porocarcinoma in that diagnosis was delayed for many years after the initial lesion appeared, resulting in relatively large tumor.  (+info)

Poromatosis: the occurrence of multiple eccrine poromas. (4/8)

Eccrine poromas are rare, benign adnexal tumors derived from the intraepidermal portion of sweat ducts. Historically they were thought to arise from eccrine ducts although today it is thought that they may also have an apocrine origin. They usually appear as solitary, slow-growing, skin-colored papules on acral surfaces. Here we present the unusual situation of a patient with multiple poromas only three of which are located near the distal extremities.  (+info)

Eccrine poroma: a clinical-dermoscopic study of seven cases. (5/8)

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Poroma of the hip and buttock. (6/8)

Poroma is a benign adnexal skin tumor seen in middle aged individuals with no sex predilection. The acral sites are the most commonly affected regions. Hip or buttock as a location of origin has rarely been reported. We report two cases of poroma, one located on the hip of a 75-year-old man and the other on the buttock of a 60-year-old man.  (+info)

EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours. (7/8)

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Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. (8/8)

Eccrine acrospiroma, better known as eccrine poroma, is a benign adnexal neoplasm of the skin. Its clinical aspect can masquerade as some other nodular and cystic lesions. The current dermoscopy literature offers very few case studies. Moreover, these very few examples present a totally different appearance pattern compared to the one we examined. Its homogeneous blue pattern suggested the better-known nodular malignant melanoma; in fact, this dermoscopic appearance was due to the Tyndall effect.  (+info)

Looking for online definition of eccrine acrospiroma in the Medical Dictionary? eccrine acrospiroma explanation free. What is eccrine acrospiroma? Meaning of eccrine acrospiroma medical term. What does eccrine acrospiroma mean?
Acrospiroma: A rare cutaneous tumor of eccrine sweat gland origin. It is most commonly found on the extremities and is usually benign. There is no indication that heredity or external agents cause these tumors.
Hidradenoma (also known as acrospiroma, from akral peripheral + spiroma epithelial tumor of sweat gland) refers to a benign adnexal tumor of the apical sweat gland. Another name for Hidradenoma is Cystadenoma and Hydrocystadenomas. These are 1-3 cm translucent blue cystic nodules.It usually presents as a single, small skin-colored lesion, and is considered distinct from the closely related poroma. Hidradenomas are often sub-classified based on subtle histologic differences, for example:[citation needed] clear-cell hidradenoma or acrospiroma nodular hidradenoma or acrospiroma solid-cystic hidradenoma Discussion of sweat gland tumors can be difficult and confusing due to the complex classification and redundant terminology used to describe the same tumors. For example, acrospiroma and hidradenoma are synonymous, and sometimes the term acrospiroma is used to generally describe benign sweat gland tumors. In addition, a single lesion may contain a mixture of cell-types. There has also been a ...
INTRODUCTION. Eccrine porocarcinoma was first described by Pinkus and Mehregan in 1963.1 It is a rare, malignant neoplasm that originates in the eccrine sweat glands acrosyringium, representing between 0.005 and 0.01% of skin tumors.2 It usually occurs in elderly people and women, with predominance of lower limb lesions, followed by trunk and head.3 It is clinically presented in varied forms and metastases may occur in 20% of cases for regional lymph nodes and in 10% of cases for internal organs.4 A normal computerized tomography indicates a better prognosis.5 Many therapeutic possibilities have been reported, with variable results; it is more common to propose conventional surgical removal or Mohs micrographic surgery. Surgical excision of the primary lesion is curative in 70 to 80% of cases.4 The objective of this report is to present a rare neoplastic lesion of chronic progression and large dimensions, whose diagnosis was delayed by the clinical presentation and whose treatment proved to be ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Several years ago, Ian McDonell, a Staff Sergeant with the Ottawa Police and father of three had just lost his father to cancer and his brother was dying of melanoma. Ians wife insisted he see his physician to check out a mole on his back. It turned out to be an ulcerated nodular malignant melanoma - an aggressive form of skin cancer.. Ian had surgery to remove it along with a lymph node from his left groin. Several weeks later, he had a lymph node removed from his armpit. Following these surgeries, he had no signs of cancer, but due to his familys history, Ian was at high risk for relapse.. Sobering news. Ian was feeling well, but during a standard monitoring visit in June 2017, his CT and MRI scans showed sobering news. He had half a dozen tumours in his groin and abdomen, and three more tumours metastasized to his brain. Ians cancer was stage 4.. Given the severity of the findings, Dr. Michel Ong at The Ottawa Hospital suggested an aggressive approach - a recently approved immunotherapy ...
This study shows for the first time that the tandemly repeated icosapeptide of human MUC1 underlies a genetic sequence polymorphism at three positions (underlined): PDTRPAPGSTAPPAHGVTSA. The concerted replacement DT--|ES (sequence variation 1) and the single replacements P--|Q (sequence variation 2), P--|A (sequence variation 3), and P--|T (sequence variation 4) were identified by sequencing of polymerase chain reaction products and studied by minisatellite variant repeat analysis for their incidence and topology in the 5 and 3 peripheral regions of the variable number of tandem repeats domain. Minisatellite variant repeat analyses were performed with 27 individual samples of genomic DNA from human cells and tissues covering 30-60% of the domain. Within the peripheral regions, sequence variations 1-4 occur at high incidence and show a nearly constant repeat topology in all individual normal and tumor samples. Also, individuals who were non-Caucasian or of different ethnic background were found to have
Tidwell WJ, Mayer JE, Malone J, Schadt C, Brown T. Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review. Int J Dermatol. 2015 Sep;54(9):1078-83. doi: 10.1111/ijd.12997. Epub 2015 Jul 23. Review. PubMed PMID: 26205087 ...
Eccrine poroma originates from eccrine sweat glands of skin. The usual site of its occurrence is palm or sole. Exact cause of this tumor is not known but it is believed to be caused as a result of genetic mutation.
Normal and malignant cells release a variety of different vesicles into their extracellular environment. The most prominent vesicles are the microvesicles (MVs, 100-1 000 nm in diameter), which are shed of the plasma membrane, and the exosomes (70-120 nm in diameter), derivates of the endosomal system. MVs have been associated with intercellular communication processes and transport numerous proteins, lipids and RNAs. As essential component of immune-escape mechanisms tumor-derived MVs suppress immune responses. Additionally, tumor-derived MVs have been found to promote metastasis, tumor-stroma interactions and angiogenesis. Since members of the carcinoembryonic antigen related cell adhesion molecule (CEACAM)-family have been associated with similar processes, we studied the distribution and function of CEACAMs in MV fractions of different human epithelial tumor cells and of human and murine endothelial cells. Here we demonstrate that in association to their cell surface phenotype, MVs released ...
The poroid family of neoplasms includes hidroacanthoma simplex, eccrine poroma, dermal duct tumor, and poroid hidradenoma. These benign adnexal neoplasms are derived from the eccrine or apocrine sweat ducts or glands. Poroid neoplasms, including poro
Poroid neoplasms (PN)在傳統的分類上包含四種良性的汗腺瘤:單純汗腺瘤 (hidracanthoma simplex, HS)、汗腺汗孔瘤 (eccrine poroma, EP)、真皮汗管瘤 (dermal duct tumor, DDT)、汗孔樣汗腺瘤 (poroid hidradenoma, PH)。此些中文譯名容易相互混淆,在本文中將使用英文簡稱或直接以英文代替以利閱讀。 HS 完全局限於表皮內(Fig. 1),而DDT及PH (Fig. 2)則完全局限於真皮層裡;至於EP(Fig. 3)則介於兩者之間;在一 ..................More ...
Hypoxia is a key regulatory factor in tumour growth, activating angiogenesis, glycolysis and cell migration. It is readily recognized by the intracellular accumulation of hypoxia-inducible factor 1alpha (HIF1alpha) and HIF2alpha. Accumulation of HIF1alpha and HIF2alpha was detected immunohistochemically in a series of 46 nodular malignant melanomas of the skin (epithelioid cell variant), treated with wide local excision. The results were correlated with vascular density (VD) and expression of the angiogenesis-stimulating factors vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP). Further associations were sought with patient prognosis and the important histopathological features of Breslows thickness, Clarks level of invasion, mitotic rate, inflammatory cell infiltrates and tumour ulceration. HIF1alpha and HIF2alpha accumulation in malignant melanomas was directly correlated with VEGF expression. Tumours with high VEGF or HIF2alpha expression were associated with a poorer
OBJECTIVES: To investigate the expression of luminal (K77), peripheral (K1) and further discriminatory keratins in two eccrine sweat gland tumours: syringoma, thought to show differentiation towards luminal cells of intraepidermal sweat ducts and eccrine poroma, considered to arise from poroid cells, i.e. peripheral duct cells; and keratinocytes of the lower acrosyringium/sweat duct ridge differentiating towards cells of intradermal/intraepidermal duct segments ...
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Eccrine acrospiroma Clear-cell hidradenoma or acrospiroma Nodular hidradenoma or acrospiroma Solid-cystic hidradenoma ... For example, acrospiroma and hidradenoma are synonymous, and sometimes the term acrospiroma is used to generally describe ... Gross pathology of a cystic nodular hidradenoma Dermal duct tumor Acrospiroma, solid type Acrospiroma, clear cell type ... "Acrospiroma: a case report and review". Cutis. 58 (5): 349-51. PMID 8934076. Obaidat NA, Alsaad KO, Ghazarian D (February 2007 ...
Spiradenoma Malignant acrospiroma James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical ...
Eccrine acrospiroma Clear cell hidradenoma M8402/3 Nodular hidradenoma, malignant (C44._) Hidradenocarcinoma M8403/0 Eccrine ...
Acrospiroma List of cutaneous conditions List of cutaneous neoplasms associated with systemic syndromes James, William D.; ...
Syringoma Acrospiroma Seborrheic keratosis List of cutaneous conditions List of cutaneous neoplasms associated with systemic ...
... (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine carcinoma, or primary ...
Aberrant basal cell carcinoma Acanthoma fissuratum (granuloma fissuratum, spectacle frame acanthoma) Acrospiroma (clear cell ... Malignant acrospiroma (spiradenocarcinoma) Malignant mixed tumor (malignant chondroid syringoma) Malignant trichilemmal cyst ...
... acrospiroma, eccrine MeSH C04.557.470.035.175.375 - hidrocystoma MeSH C04.557.470.035.175.800 - syringoma MeSH C04.557.470.035. ... acrospiroma, eccrine MeSH C04.557.470.550.175.375 - hidrocystoma MeSH C04.557.470.550.175.800 - syringoma MeSH C04.557.470.550. ...
Malignant acrospiroma List of cutaneous conditions Dermal cylindroma Trichoepithelioma CYLD cutaneous syndrome List of ...
This part of the sweat gland duct is termed the acrosyringium and had led to grouping poromas in the acrospiroma class of skin ...
... dysplasia Acrophobia Acropigmentation of Dohi Acrorenal syndrome recessive Acrorenoocular syndrome Acrospiroma ACTH deficiency ...
... tumors include: Acrospiroma Aggressive digital papillary adenocarcinoma Apocrine gland carcinoma Ceruminoma ...
... also termed clear cell acrospiroma), nodular hidradenoma (also termed nodular acrospiroma, clear cell myoepithelioma, and ... Media related to Acrospiroma at Wikimedia Commons v t e (Articles with short description, Short description matches Wikidata, ... The acrosporma group of tumors consists of: 1) the hidradenomas, including their eccrine acrospiroma, clear cell hidradenoma ( ... Helwig EB (October 1984). "Eccrine acrospiroma". Journal of Cutaneous Pathology. 11 (5): 415-20. doi:10.1111/j.1600-0560.1984. ...
A malignant acrospiroma is a sweat gland carcinoma of the hand, which may recur locally in 50% of patients after excision, with ... Acrospiroma Syringoma Hidrocystoma List of cutaneous conditions Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007 ... ISBN 978-1-4160-2999-1. Wilson KM, Jubert AV, Joseph JI (May 1989). "Sweat gland carcinoma of the hand (malignant acrospiroma ...
... also termed clear cell acrospiroma), nodular hidradenoma (also termed nodular acrospiroma, clear cell myoepithelioma, and ... Media related to Acrospiroma at Wikimedia Commons v t e (Articles with short description, Short description matches Wikidata, ... The acrosporma group of tumors consists of: 1) the hidradenomas, including their eccrine acrospiroma, clear cell hidradenoma ( ... Helwig EB (October 1984). "Eccrine acrospiroma". Journal of Cutaneous Pathology. 11 (5): 415-20. doi:10.1111/j.1600-0560.1984. ...
Acrospiroma Current Synonym true false 1787098018 Clear cell myoepithelioma Current Synonym true false ...
Acrospiroma Medicina y ciencias biológicas 100% * Skin Medicina y ciencias biológicas 34% ...
acrospiroma. (across). • across. across a broad front. across chest. across classes. across country. across from. across ...
Different neoplasms have been described under a single name (e.g. acrospiroma), and various names have been used to describe ... and eccrine acrospiroma (1.17%; 1/85) were the third most prevalent group.. The least common SATs were cylindroma (1/85; 1.17 ...
Acrospiroma. *ACSL4-related intellectual disability. *ACTG2-related disorders *ACTH-independent macronodular adrenal ...
Eccrine acrospiroma of eye lid--a case report.. Jagannath, C; Sandhya, C S; Venugopalachari, K. ...
Acrospiroma. *Adult Soft Tissue Sarcoma. *Alopecia Areata. *Alternating Hemiplegia of Childhood. *Anaplastic Large Cell ...
Return to Article Details Clinicopathological Evaluation of Clear Cell Hidradenoma (Acrospiroma) Within Multiple Tumor Complex ...
Eccrine acrospiroma (clear cell hidradenoma) of the eyelid. Immunohistochemical and ultrastructural features. Grossniklaus HE, ...
Pérez, A., Rütten, A., Gold, R., Urbina, F., Misad, C., Izquierdo, M. J., Requena, C., Aliaga, A., Kutzner, H. & Requena, L., 1 Jul 2002, In: Journal of the American Academy of Dermatology. 47, 1, p. 21-27 7 p.. Research output: Contribution to journal › Article › peer-review ...
SGc arises from the adnexal epithelium of sebaceous glands, most commonly the Meibomian glands or glands of Zeis.[9][6] On histology, there are irregular lobules of different sizes with undifferentiated cells and distinct sebaceous cells with a foamy cytoplasm.[9] The pathogenesis of SGc remains poorly understood.[5] The majority of SGc are solitary and sporadic and believed to be associated with such factors as ultraviolet exposure, radiotherapy, and immunosuppression.[10] Other SGc including those occurring outside of the head and neck region and the presentation of multiple at a time are believed to be associated with genetic defects including defects in mismatch repair genes, Muir-Torre syndrome (MTS), and familial retinoblastoma.[11][10][9] The observation of extraocular SGc arising from Bowen disease or actinic keratosis and the predisposition of SGc to arise in sun-exposed areas suggest a role for ultraviolet exposure or intraepidermal neoplasia in the pathogenesis of some SGc in ...
acrospiroma. Akrosticha {pl}. acrostics. akrostichisch. acrostic. Akrostichon {n} acrostic. akrostisch. acrostic. Akrosyndese { ...
Different neoplasms have been described under a single name (e.g. acrospiroma), and various names have been used to describe ... and eccrine acrospiroma (1.17%; 1/85) were the third most prevalent group.. The least common SATs were cylindroma (1/85; 1.17 ...
Giant eccrine acrospiroma of the scalp. p. 238. Richa Todi, Chiranth Gowda, Kantilatha Pai, Gabriel Rodrigues. DOI:10.4103/JCAS ... Eccrine acrospiroma is a benign skin tumor that arises from the ducts of sweat glands, presents as small solid or cystic ... with a large pedunculated tumor of the scalp that was excised and histopathologically proven to be a giant eccrine acrospiroma ...
Acrospiroma - An acrospiroma (also known as a Clear cell hidradenoma, Dermal duct tumor, Hidroacanthoma simplex, Nodular ...
John Cope is a General Surgeon in Brattleboro, Vermont...
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record. ...
  • Several cases have been published under various names, called MNH, clear cell hidradenocarcinoma, malignant clear cell hidradenoma, malignant clear cell myoepithelioma, and malignant acrospiroma. (handmicro.org)
  • Acrospiroma - An acrospiroma (also known as a Clear cell hidradenoma, Dermal duct tumor, Hidroacanthoma simplex, Nodular hidradenoma, and Poroma [1]:665) is a tumor of the distal portion of a sweat gland. (en-academic.com)
  • 19. Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. (nih.gov)
  • Nodular hidradenoma , also known as eccrine acrospiroma or clear cell hidradenoma, is a dermal adnexal tumor that most commonly appears in the head and neck area or the extremities. (medscape.com)