Acrosin. Medical search

A trypsin-like enzyme of spermatozoa which is not inhibited by alpha 1 antitrypsin.

Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.

The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.

Physiologically inactive substances that can be converted to active enzymes.

A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.

A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.

Interactive processes between the oocyte (OVUM) and the sperm (SPERMATOZOA) including sperm adhesion, ACROSOME REACTION, sperm penetration of the ZONA PELLUCIDA, and events leading to FERTILIZATION.

Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.

Changes that occur to liberate the enzymes of the ACROSOME of a sperm (SPERMATOZOA). Acrosome reaction allows the sperm to penetrate the ZONA PELLUCIDA and enter the OVUM during FERTILIZATION.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.

A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

The portion of an interactive computer program that issues messages to and receives commands from a user.

Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.

The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).

A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES. It has specificity for B CELL ACTIVATING FACTOR and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.

Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.

A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.

A tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.

A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.

An enzyme that catalyzes the hydrolysis of an alpha L-fucoside to yield an alcohol and L-fucose. Deficiency of this enzyme can cause FUCOSIDOSIS. EC 3.2.1.51.

Proteins found in the microtubules.

The maturing process of SPERMATOZOA after leaving the testicular SEMINIFEROUS TUBULES. Maturation in SPERM MOTILITY and FERTILITY takes place in the EPIDIDYMIS as the sperm migrate from caput epididymis to cauda epididymis.

The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.

Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.

Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.

Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.

A country spanning from central Asia to the Pacific Ocean.

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.

Methods of comparing two or more samples on the same two-dimensional gel electrophoresis gel.

An enzyme that catalyzes reversibly the conversion of D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate. A deficiency in humans causes nonspherocytic hemolytic disease (ANEMIA, HEMOLYTIC, CONGENITAL NONSPHEROCYTIC). EC 5.3.1.1.

Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.

Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.

The systematic study of the complete complement of proteins (PROTEOME) of organisms.

The protein complement of an organism coded for by its genome.

Changes in hyaluronidase, acrosin, and N-acetylhexosaminidase activities of dog sperm after incubation. (1/189)

Hyaluronidase, acrosin and N-acetylhexosaminidase activities were examined in sperm collected from 12 beagle dogs and in culture medium after 0.5 hr and 7 hr of sperm incubation. The activities of the three enzymes were significantly higher at 7 hr than at 0.5 hr (P < 0.05, 0.01), and the increases were associated with sperm capacitation. It was considered that the three enzymes in the dog sperm are related to fertilization by reason of the findings of the release of these enzymes from the sperm into the medium after 7 hr of incubation. (+info)

Immunolocalization of CRES (Cystatin-related epididymal spermatogenic) protein in the acrosomes of mouse spermatozoa. (2/189)

The CRES (cystatin-related epididymal spermatogenic) protein is a member of the cystatin superfamily of cysteine protease inhibitors and exhibits highly restricted expression in the reproductive tract. We have previously shown that CRES protein is present in elongating spermatids in the testis and is synthesized and secreted by the proximal caput epididymal epithelium. The presence of CRES protein in developing germ cells and in the luminal fluid surrounding maturing spermatozoa prompted us to examine whether CRES protein is associated with spermatozoa. In the studies presented, indirect immunofluorescence, immunogold electron microscopy, and Western blot analysis demonstrated that CRES protein is localized in sperm acrosomes and is released during the acrosome reaction. Interestingly, while the 19- and 14-kDa CRES proteins were present in testicular and proximal caput epididymal spermatozoa, the 14-kDa CRES protein was the predominant form present in mid-caput to cauda epididymal spermatozoa. Furthermore, following the ionophore-induced acrosome reaction, CRES protein localization was similar to that of proacrosin/acrosin in that it was detected in the soluble fraction as well as associated with the acrosome-reacted spermatozoa. The presence of CRES protein in the sperm acrosome, a site of high hydrolytic and proteolytic activity, suggests that CRES may play a role in the regulation of intraacrosomal protein processing or may be involved in fertilization. (+info)

Effect of recombinant boar beta-acrosin on sperm binding to intact zona pellucida during in vitro fertilization. (3/189)

In a previous paper we demonstrated that boar beta-acrosin recombinant proteins were able to bind non-enzymatically to solubilized pig zona pellucida (ZP) glycoproteins. Here we report the participation of boar beta-acrosin in the secondary binding of sperm to intact pig ZP. This was achieved by using two boar recombinant proteins: beta-acrosin and a mutant of the catalytic site, beta-acrosin Ser/Ala(222). Assays of binding between the iodinated recombinant beta-acrosin and whole ZP showed that this binding could be saturated, was specific, and was stable over time. Using autoradiography, we determined that recombinant beta-acrosin bound on the entire surface of the ZP but initially was distributed heterogeneously. This suggests that the ligands for beta-acrosin may not be homogeneously distributed on the ZP. To study the contribution of acrosin in sperm secondary binding to the ZP, we preincubated in vitro-matured oocytes with these recombinant proteins and then performed in vitro fertilization assays. Under the experimental conditions used, binding of beta-acrosin recombinant proteins did not block sperm penetration. These results suggest that there may be other proteins that participate in the secondary binding, and that these proteins may recognize ligands that are different from those blocked by beta-acrosin recombinant proteins. (+info)

Tissue-inherent fate of GPI revealed by GPI-anchored GFP transgenesis. (4/189)

To clarify the fate of glycosylphosphatidylinositol (GPI) in mammals, we developed GPI-anchored enhanced green fluorescent protein (EGFP-GPI) and transgenic mice carrying this fusion construct. When it was introduced to culture cells, the EGFP-GPI protein was correctly sorted to plasma membranes and microsomes depending on GPI biosynthesis. Transgenic mice carrying EGFP-GPI were found to show a broad transgene expression. Histologically, a prominent polarized localization of EGFP-GPI protein was observed in various epithelia, the nervous system and liver and secreted from some exocrine glands, as well as non-polarized presence in non-epithelial tissues, demonstrating a tissue-inherent manner of GPI sorting. (+info)

Expression of human proacrosin in Escherichia coli and binding to zona pellucida. (5/189)

Proacrosin is a multifunctional protein present in the sperm acrosome. This study characterizes the expression of human proacrosin in bacteria and assesses zona pellucida binding activity. The cDNA encoding human proacrosin was subcloned in pGEX-3X and pET-22b vectors. In the pGEX system, expression of the full-length fusion protein was not detected. In the pET system, an expression product with an apparent molecular size similar to that expected for the proenzyme (Rec-40, 42-44 kDa) was recognized by a monoclonal antibody to human acrosin, AcrC5F10. A 32-34-kDa protein (Rec-30), not recognized by AcrC5F10 on Western blots, was the major expression product. Proteins of 21 (Rec-20) and 18 (Rec-10) kDa were recovered as insoluble expression products as were Rec-40 and Rec-30, and truncated products from the C terminus were detected in the soluble fraction. Rec-40 and Rec-30 coexisted at any culture time tested. Immune serum raised against Rec-30 (AntiRec-30) stained the acrosomal region of permeabilized human spermatozoa and recognized the recombinant proteins and proacrosin from human sperm extracts. Amino acid sequence analysis indicated that Rec-30, Rec-20, and Rec-10 are N-terminal fragments of proacrosin. The recombinant proteins Rec-40, -30, -20, and -10 were found to interact with homologous (125)I-zona pellucida glycoproteins. (+info)

The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: structural alterations. (6/189)

The acrosome is an acidic secretory vesicle containing hydrolytic enzymes that are involved in the sperm's passage across the zona pellucida. Imaging of the acrosomal vesicle and the Golgi apparatus in live rhesus monkey spermatids was accomplished by using the vital fluorescent probe LysoTracker DND-26. Concurrently, the dynamics of living spermatid mitochondria was visualized using the specific probe MitoTracker CMTRos and LysoTracker DND-26 detected the acrosomal vesicle from its formation through spermatid differentiation. LysoTracker DND-26 also labeled the Golgi apparatus in spermatogenic cells. In spermatocytes the Golgi is spherical and, in round spermatids, it is localized over the acrosomal vesicle, as confirmed by using polyclonal antibodies against Golgin-95/GM130, Golgin-97, and Golgin-160. Using both live LysoTracker DND-26 imaging and Golgi antibodies, we found that the Golgi apparatus is cast off from the acrosomal vesicle and migrates toward the sperm tail in elongated spermatids. The Golgi is discarded in the cytoplasmic droplet and is undetectable in mature ejaculated spermatozoa. The combined utilization of three vital fluorescent probes (Hoechst 33342, LysoTracker DND-26, and MitoTracker CMTRos) permits the dynamic imaging of four organelles during primate spermiogenesis: the nucleus, the mitochondria, the acrosomal vesicle, and the Golgi apparatus. (+info)

A basic 18-amino acid peptide contains the polysulfate-binding domain responsible for activation of the boar proacrosin/acrosin system. (7/189)

Proacrosin is the zymogen of acrosin, a serine protease localized in the acrosomal matrix of mammalian sperm. Proacrosin/acrosin binds to solubilized zona pellucida glycoproteins (ZPGs) and various polysulfates in a non-enzymatic mechanism. In addition, both polysulfates and ZPGs induce proacrosin activation once they bind to the polysulfate-binding domain (PSBD) of the enzyme. We show here that the peptide (43)IFMYHNNRRYHTCGGILL(60) inhibited the proacrosin activation induced by either fucoidan or ZPGs. In addition, the peptide was recognized by the monoclonal antibody C5F10, which is directed against the PSBD region. Our data suggest that the PSBD is composed of many "subsites" that may or may not interact with each other. (+info)

Trypsin/acrosin inhibitor activity of rat and guinea pig caltrin proteins. Structural and functional studies. (8/189)

Dramatic inhibition of trypsin activity by rat caltrin and guinea pig caltrin I was spectrophotometrically demonstrated using the artificial substrate benzoylarginyl ethyl ester. Approximately 6% and 21% of residual proteolytic activity was recorded after preincubating the enzyme with 0.22 and 0.27 microM rat caltrin and guinea pig caltrin I, respectively. Reduction and carboxymethylation of the cysteine residues abolished the inhibitor activity of both caltrin proteins. Rat caltrin and guinea pig caltrin I show structural homology with secretory trypsin/acrosin inhibitor proteins isolated from boar and human seminal plasma and mouse seminal vesicle secretion and share a fragment of 13 amino acids of almost identical sequence (DPVCGTDGH/K/ITYG/AN), which is also present in the structure of Kazal-type trypsin inhibitor proteins from different mammalian tissues. Bovine, mouse, and guinea pig caltrin II, three caltrin proteins that have no structural homology with rat caltrin or guinea pig caltrin I, lack trypsin inhibitor activity. Rat caltrin, guinea pig caltrin I, and the mouse seminal vesicle trypsin inhibitor protein P12, which also inhibits Ca(2+) uptake into epididymal spermatozoa (mouse caltrin I), bound specifically to the sperm head, on the acrosomal region, as detected by indirect immunofluorescence. They also inhibited the acrosin activity in the gelatin film assay. Caltrin I may play an important role in the control of sperm functions such as Ca(2+) influx in the acrosome reaction and activation of acrosin and other serine-proteases at the proper site and proper time to ensure successful fertilization. (+info)

... acrosin inhibitor; and elastase inhibitor. These proteins contain between 1 and 7 Kazal-type inhibitor repeats. The structure ...

https://en.wikipedia.org/wiki/Kazal_domain

Acrosin digests the zona pellucida and membrane of the oocyte. Part of the sperm's cell membrane then fuses with the egg cell's ... In mammals, the acrosome reaction releases hyaluronidase and acrosin; their role in fertilization is not yet clear. The ... by releasing hyaluronidase from the acrosome to digest cumulus cells surrounding the oocyte and exposing acrosin attached to ...

https://en.wikipedia.org/wiki/Acrosome_reaction

Evidence for the presence of spermosin, a novel acrosin-like enzyme". The Journal of Biological Chemistry. 259 (5): 2900-4. ... Sawada H, Someno T (October 1996). "Substrate specificity of ascidian sperm trypsin-like proteases, spermosin and acrosin". ... spermosin and acrosin, in fertilization of the ascidian, Halocynthia roretzi: inhibitory effects of leupeptin analogs on enzyme ...

https://en.wikipedia.org/wiki/Spermosin

Furlong LI, Harris JD, Vazquez-Levin MH (2005). "Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) ...

https://en.wikipedia.org/wiki/ZP3

In Eutherian mammals the acrosome contains degradative enzymes (including hyaluronidase and acrosin). These enzymes break down ...

https://en.wikipedia.org/wiki/Acrosome

Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the ... Moritz A, Grzeschik KH, Wingender E, Fink E (Mar 1993). "Organization and sequence of the gene encoding the human acrosin- ... Fink E, Hehlein-Fink C, Eulitz M (1990). "Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals ... Möritz A, Lilja H, Fink E (1991). "Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin ...

https://en.wikipedia.org/wiki/SPINK2

... has a role in reproduction as it has ability to inhibit the sperm protease acrosin. Large amounts of ... Zheng X, Geiger M, Ecke S, Bielek E, Donner P, Eberspächer U, Schleuning WD, Binder BR (August 1994). "Inhibition of acrosin by ...

https://en.wikipedia.org/wiki/Protein_C_inhibitor

B. bimaculatus venom contains additional proteins, including acrosin and a tryptic amidase related to clotting enzymes. "Bombus ...

https://en.wikipedia.org/wiki/Two-spotted_bumble_bee

This in turn causes both acrosin and hyaluronidase enzymes to leak out of the sperm, making the sperm infertile. The safety of ...

https://en.wikipedia.org/wiki/Reversible_inhibition_of_sperm_under_guidance

C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochimica et Biophysica Acta (BBA) - Protein Structure and ...

https://en.wikipedia.org/wiki/Complement_component_1s

acrosin binding. • GO:0001948 protein binding. • carbohydrate binding. • identical protein binding. • receptor ligand activity ... Furlong LI, Harris JD, Vazquez-Levin MH (2005). "Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) ...

https://en.m.wikipedia.org/wiki/ZP3

Now EC 3.4.21.34 (plasma kallikrein) and EC 3.4.21.35 (tissue kallikrein) EC 3.4.21.9: enteropeptidase EC 3.4.21.10: acrosin EC ...

https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_3)

... acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play ...

https://en.wikipedia.org/wiki/TMPRSS11D

... acrosin - actin - action potential - activation energy - active site - active transport - adenosine - adenosine diphosphate ( ...

https://en.wikipedia.org/wiki/Index_of_biochemistry_articles

... may refer to: Albumin/creatinine ratio in urine ACR score for rheumatoid arthritis ACR gene, encoding the enzyme acrosin ...

https://en.wikipedia.org/wiki/ACR

Acrosin (EC 3.4.21.10) Factor VII (EC 3.4.21.21) Factor IX (EC 3.4.21.22) Prolyl oligopeptidase (EC 3.4.21.26) Factor XI (EC ...

https://en.wikipedia.org/wiki/List_of_enzymes

... acrosin MeSH D08.811.277.656.300.760.176 - chymotrypsin MeSH D08.811.277.656.300.760.198 - complement factor b MeSH D08.811. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)

... or acrosin), that is necessary for fertilization. As the spermatozoon approaches the egg, it undergoes the acrosome reaction in ...

https://en.wikipedia.org/wiki/Spermatozoon

... is a digestive enzyme that acts as a protease. In humans, acrosin is encoded by the ACR gene. Acrosin is released from ... the high concentrations of PCI would inhibit acrosin from inflicting proteolytic damage on nearby tissues. β-acrosin ... Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is stored in the acrosome in its precursor ... Acrosin regulation has been found to occur through protein C inhibitor (PCI). PCI is present in the male reproductive tract at ...

https://en.wikipedia.org/wiki/Acrosin

... is a protein that in humans is encoded by the ACRBP gene. The protein encoded by this gene is similar ... "Entrez Gene: Acrosin binding protein". Retrieved 2016-08-01. Okumura H, Noguchi Y, Uenaka A, Aji T, Ono T, Nakagawa K, Aoe M, ... the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin ...

https://en.wikipedia.org/wiki/Acrosin_binding_protein

... a is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is an enzyme, a serine endopeptidase, which plays a key role at several stages of the coagulation system. Factor X is synthesized in the liver. The most commonly used anticoagulants in clinical practice, warfarin and the heparin series of anticoagulants and fondaparinux, act to inhibit the action of Factor Xa in various degrees. Traditional models of coagulation developed in the 1960s envisaged two separate cascades, the extrinsic (tissue factor (TF)) pathway and the intrinsic pathway. These pathways converge to a common point, the formation of the Factor Xa/Va complex which together with calcium and bound on a phospholipids surface generate thrombin (Factor IIa) from prothrombin (Factor II). A new model, the cell-based model of anticoagulation appears to explain more fully the steps in coagulation. This model has three stages: 1) initiation of coagulation on TF-bearing ...

https://en.wikipedia.org/wiki/Factor_X

Acrosin. *Alpha-lytic endopeptidase. *Alternative-complement-pathway C3/C5 convertase. *Aqualysin 1 ...

https://en.wikipedia.org/wiki/Category:EC_3.4.21

Protein HtrA2, also known as Omi, is a mitochondrially-located serine protease. The human protein Serine protease HTRA2, mitochondrial is 49kDa in size and composed of 458 amino acids. The peptide fragment of 1-31 amino acid is the mitochondrial transition sequence, fragment 32-133 amino acid is propertied, and 134-458 is the mature protein Serine protease HTRA2, mitochondrial, and its theoretical pI of this protein is 6.12.[10] HtrA2 shows similarities with DegS, a bacterial protease present in the periplasm of gram-negative bacteria. Structurally, HtrA2 is a trimeric molecule with central protease domains and a carboxy-terminal PDZ domain, which is characteristic of the HtrA family. The PDZ domain preferentially binds C-terminus of the protein substrate and modulate the proteolytic activity of the trypsin-like protease domain.[11] ...

https://en.wikipedia.org/wiki/HtrA_serine_peptidase_2

Seol JH, Woo SK, Jung EM, Yoo SJ, Lee CS, Kim KJ, Tanaka K, Ichihara A, Ha DB, Chung CH (April 1991). "Protease Do is essential for survival of Escherichia coli at high temperatures: its identity with the htrA gene product". Biochemical and Biophysical Research Communications. 176 (2): 730-6. doi:10.1016/s0006-291x(05)80245-1. PMID 2025286 ...

https://en.wikipedia.org/wiki/Peptidase_Do

A trypsin inhibitor (TI) is a protein and a type of serine protease inhibitor (serpin) that reduces the biological activity of trypsin by controlling the activation and catalytic reactions of proteins.[1] Trypsin is an enzyme involved in the breakdown of many different proteins, primarily as part of digestion in humans and other animals such as monogastrics and young ruminants. When trypsin inhibitor is consumed it acts as an irreversible and competitive substrate.[2] It competes with proteins to bind to trypsin and therefore renders it unavailable to bind with proteins for the digestion process.[1] As a result, protease inhibitors that interfere with digestion activity have an antinutritional effect. Therefore, trypsin inhibitor is considered an anti-nutritional factor or ANF.[3] Additionally, trypsin inhibitor partially interferes with chymotrypsin function. Trypsinogen is an inactive form of trypsin, its inactive form ensures protein aspects of the body, such as the pancreas and muscles, are ...

https://en.wikipedia.org/wiki/Trypsin_inhibitor

Cholecystokinin (CCK) is a unique peptide released by the duodenal "I cells" in response to chyme containing high fat or protein content. Unlike secretin, which is an endocrine hormone, CCK actually works via stimulation of a neuronal circuit, the end-result of which is stimulation of the acinar cells to release their content.[5] CCK also increases gallbladder contraction, causing release of pre-stored bile into the cystic duct, and eventually into the common bile duct and via the ampulla of Vater into the second anatomic position of the duodenum. CCK also decreases the tone of the sphincter of Oddi, which is the sphincter that regulates flow through the ampulla of Vater. CCK also decreases gastric activity and decreases gastric emptying, thereby giving more time to the pancreatic juices to neutralize the acidity of the gastric chyme ...

https://en.wikipedia.org/wiki/Digestive_enzyme

Acrosin (EC 3.4.21.10). *Factor VII (EC 3.4.21.21). *Factor IX (EC 3.4.21.22) ...

https://en.m.wikipedia.org/wiki/List_of_enzymes

Acrosin is a digestive enzyme that acts as a protease. In humans, acrosin is encoded by the ACR gene. Acrosin is released from ... the high concentrations of PCI would inhibit acrosin from inflicting proteolytic damage on nearby tissues. β-acrosin ... Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is stored in the acrosome in its precursor ... Acrosin regulation has been found to occur through protein C inhibitor (PCI). PCI is present in the male reproductive tract at ...

https://en.wikipedia.org/wiki/Acrosin

Acrosin binding protein is a protein that in humans is encoded by the ACRBP gene. The protein encoded by this gene is similar ... "Entrez Gene: Acrosin binding protein". Retrieved 2016-08-01. Okumura H, Noguchi Y, Uenaka A, Aji T, Ono T, Nakagawa K, Aoe M, ... the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin ...

https://en.wikipedia.org/wiki/Acrosin_binding_protein

BETA-ACROSIN HEAVY CHAINBETA-ACROSIN LIGHT CHAIN2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSEBETA-D-MANNOSEBETA-L-FUCOSEP-AMINO ...

https://www.ncbi.nlm.nih.gov/Structure/pdb/1FIZ

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is ... "Acrosin inhibitor in extract of the zonae pellucidae of porcine oocytes.". Veselsky L., Cechova D., Jonakova V.. Int. J. Fertil ... "Kinetics of inhibition of sperm beta-acrosin activity by suramin.". Hermans J.M., Haines D.S., James P.S., Jones R.. FEBS Lett ... "Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.". Zheng X., Geiger M., ...

https://www.uniprot.org/uniprot/P08001

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is ... AcrosinAdd BLAST. 402. ,p>This subsection of the PTM / Processing section describes the extent of a polypeptide chain in the ... Acrosin light chainAdd BLAST. 23. ,p>This subsection of the PTM / Processing section describes the extent of a polypeptide ... "Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.". Zheng X., Geiger M., ...

http://www.uniprot.org/uniprot/P10323

... acrosin explanation free. What is acrosin? Meaning of acrosin medical term. What does acrosin mean? ... Looking for online definition of acrosin in the Medical Dictionary? ... Release of acrosin and acrosin inhibitor from human spermatozoa.. Spermicidal action of a protein isolated from ethanolic root ... Acrosin , definition of acrosin by Medical dictionary https://medical-dictionary.thefreedictionary.com/acrosin ...

https://medical-dictionary.thefreedictionary.com/acrosin

THREE DIMENSIONAL STRUCTURE OF BETA-ACROSIN FROM BOAR SPERMATOZOA ... BETA-ACROSIN HEAVY CHAIN. A. 263. Sus scrofa. Mutation(s): 0 ... Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.. Tranter, R., Read, J.A., Jones, R., Brady, ... beta-acrosin is thought to be multifunctional with roles in acrosomal exocytosis, as a receptor for zona pellucida proteins, ... During fertilization proacrosin autoactivates to form beta-acrosin, in which there is a light chain cross-linked to a heavy ...

https://www.rcsb.org/structure/1fiz

Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.. Tranter, R., Read, J.A., Jones, R., Brady, ... beta-acrosin is thought to be multifunctional with roles in acrosomal exocytosis, as a receptor for zona pellucida proteins, ... During fertilization proacrosin autoactivates to form beta-acrosin, in which there is a "light" chain cross-linked to a "heavy ... During fertilization proacrosin autoactivates to form beta-acrosin, in which there is a "light" chain cross-linked to a "heavy ...

https://www.rcsb.org/structure/1FIW

acrosin binding protein , proacrosin binding protein sp32 , acrosin-binding protein-like , acrosin-binding protein , cancer/ ... Acrosin Binding Protein (ACRBP) Antigen-Profil Protein Überblick The protein encoded by this gene is similar to proacrosin ... anti-Acrosin Binding Protein (ACRBP) Antikörper Primary Antibody ACRBP Reaktivität: Human ELISA, ICC, IF, WB Wirt: Kaninchen ... anti-Acrosin Binding Protein (ACRBP) Antikörper Primary Antibody ACRBP Reaktivität: Human ELISA, WB Wirt: Kaninchen Polyclonal ...

https://www.antikoerper-online.de/abstract/Acrosin+Binding+Protein+

acrosin binding protein , proacrosin binding protein sp32 , acrosin-binding protein-like , acrosin-binding protein , cancer/ ... More ELISA Kits for Acrosin Binding Protein Interaction Partners. Horse (Equine) Acrosin Binding Protein (ACRBP) interaction ... Additionally we are shipping Acrosin Binding Protein Antibodies (24) and Acrosin Binding Protein Proteins (4) and many more ... Acrosin Binding Protein (ACRBP) Antigen Profile Antigen Summary The protein encoded by this gene is similar to proacrosin ...

https://www.antibodies-online.com/abstract/Acrosin+Binding+Protein+

If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...

http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.1997.tb00250.x/pdf

What is Acrosin-trypsin inhibitor? Meaning of Acrosin-trypsin inhibitor medical term. What does Acrosin-trypsin inhibitor mean? ... Looking for online definition of Acrosin-trypsin inhibitor in the Medical Dictionary? Acrosin-trypsin inhibitor explanation ... redirected from Acrosin-trypsin inhibitor) SPINK2. A gene on chromosome 4q12 that encodes a strong inhibitor of acrosin in the ... Acrosin-trypsin inhibitor , definition of Acrosin-trypsin inhibitor by Medical dictionary https://medical-dictionary. ...

https://medical-dictionary.thefreedictionary.com/Acrosin-trypsin+inhibitor

Serum contents of immunoreactive pancreatic secretory trypsin inhibitor and seminal plasma acrosin-trypsin inhibitor in ...

https://epub.ub.uni-muenchen.de/9761/index.html

Moos J, Tesarik J, Leca G, Peknicova J. Mechanism of maturation and nature of carbohydrate chains of boar sperm acrosin. FEBS ... The antibody ACR-2 reacts with various forms of porcine acrosin (55, 53, 45 and 35 kDa), a typical serine proteinase with ... Moos J, Peknicova J, Tesarik J. Relationship between molecular conversions of acrosin and the progression of exocytosis in the ... Moos J, Peknicova J, Tesarik J. Protein-protein interactions controlling acrosin release and solubilization during the boar ...

https://www.exbio.cz/research-product/antibodies/other-intracellular-antigens/anti-por-acrosin-purified

Download Free Full-Text of an article ANDROLOGY: EVALUATION OF SPERM ACROSIN ACTIVITY AND CHROMATIN STRUCTURE IN VARICOCELE ... Total acrosin activity assessed by spectrophotometery.. Results: Total acrosin activity, percentage CMA3 positive, TUNEL ... However, Total acrosin activity was higher in these individuals and decreased to the value close to fertile control post- ... Background: Evaluation and comparison of total acrosin activity along with DNA integrity in the semen samples obtained from the ...

https://www.sid.ir/en/journal/ViewPaper.aspx?id=272419

acrosin - S1: Chymotrypsin. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of ... 1986) Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates. J. Med. Chem., 29 ... S1: Chymotrypsin: acrosin. Last modified on 14/07/2015. Accessed on 25/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www. ...

http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2327&familyId=751&familyType=ENZYME

Recombinant Protein and Acrosin-binding protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are ... Acrosin-binding protein. Acrosin-binding protein ELISA Kit. Acrosin-binding protein Recombinant. Acrosin-binding protein ... Also known as Acrosin-binding protein (Cancer/testis antigen 23) (CT23) (Cancer/testis antigen OY-TES-1) (Proacrosin-binding ... Below are the list of possible Acrosin-binding protein products. If you cannot find the target and/or product is not available ...

https://www.mybiosource.com/protein_family.php?root=acrosin-binding-protein

Recombinant Protein and Sperm-associated acrosin inhibitor Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Sperm-associated acrosin inhibitor. Sperm-associated acrosin inhibitor ELISA Kit. Sperm-associated acrosin inhibitor ... Sperm-associated acrosin inhibitor Antibody. Also known as Sperm-associated acrosin inhibitor (AI).. Inhibits acrosin.. ... Inhibits acrosin.. Below are the list of possible Sperm-associated acrosin inhibitor products. If you cannot find the target ...

https://www.mybiosource.com/protein_family.php?root=sperm-associated-acrosin-inhibitor

In pigs, acrosin activity in extended semen is correlated with reproductive performance and has recently been identified as a ... However, the effects of GSH on the acrosin activity of good and poor freezability ejaculates (GFE and PFE, respe .... DOI:. ... Its main function is control of the serine protease in the acrosome, acrosin. Here we showed for the first time that Spink is ... acrosin, etc ; acrosome; bucks; cryopreservation; freezing; goats; malondialdehyde; oxidative stress; semen; tiger nut milk; ...

https://pubag.nal.usda.gov/?q=%22acrosin%22&search_field=subject&sort=date-desc

Human Acrosin (ACR) ELISA Kit, Cat#EKU02089. Write a Review Write a Review. × ... The concentration of Acrosin (ACR) in the samples is then determined by comparing the O.D. of the samples to the standard curve ... Human Acrosin (ACR) ELISA Kit, Cat#EKU02089. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars (average). 4 stars ... The microtiter plate provided in this kit has been pre-coated with an antibody specific to Acrosin (ACR). Standards or samples ...

https://www.biomatik.com/elisa-kits/human-acrosin-acr-elisa-kit-cat-eku02089/

You searched for: Subject acrosin Remove constraint Subject: acrosin Journal Animal reproduction science Remove constraint ... 8. Proacrosin/acrosin quantification as an indicator of acrosomal integrity in fresh and frozen dog spermatozoa ... Acrosin Binding Protein (ACRBP) is specifically localized in the acrosome of germ cells of several species, including mice, ... 7. Fine structure and morphology of sterlet (Acipenser ruthenus L. 1758) spermatozoa and acrosin localization ...

https://pubag.nal.usda.gov/?f%5Bjournal_name%5D%5B%5D=Animal+reproduction+science&q=%22acrosin%22&search_field=subject&sort=relevance

p,,b,OBJECTIVE,/b,To evaluate the inhibitory effect of Nandeshi, an acrosin inhibitor, on human acrosin activity.,/p,,p,,b, ... Acrosin , Metabolism , Contraceptive Agents, Female , Pharmacology , Enzyme Inhibitors , Pharmacology , Humans , Male , ... Nandeshi: a powerful inhibitor of human acrosin activity / 中华男科学杂志 ... Nandeshi: a powerful inhibitor of human acrosin activity ... Then we determined the residual activity of human acrosin by ...

https://search.bvsalud.org/gim/resource/en/wpr-241274

Spermfunc® Acrosin Kit for The Quantitative Test of Spermatozoan Acrosin Activity ... Min. Order: 2 Kit ...

http://www.made-in-china.com/products-search/hot-china-products/Activity_Kits.html

hidrolasa (es); 加水分解酵素 (yue); Hidrolasa (eu); Гидролазы (ru); Hydrolase (de-ch); Hydrolase (de); hydrolase (en-gb); Հիդրոլազներ (hy); Хидролаза (bg); Hydrolase (da); Hidrolază (ro); 加水分解酵素 (ja); Hydroláza (sk); Idrolasa (oc); 水解酶 (wuu); 가수 분해 효소 (ko); Гидролазалар (kk); Hydrolase (en-ca); hydroláza (cs); நீராற்பகுப்பி (ta); Idrolasi (it); hydrolase (fr); Гідралязы (be-tarask); hidrolasa (ca); Hidrolaze (sr); hidrolase (pt); هیدرولاز (fa); Hidrolase (gl); Hydrolaser (sv); Hidrolazės (lt); Hüdrolaasid (et); Hidrolaz (tr); Hidrolase (pt-br); hydrolase (sco); Гідролази (uk); hydrolase (nn); hydrolase (nl); Hidrolaza (sh); 水解酶 (zh); hydrolazy (pl); Hydrolaasit (fi); Гідралазы (be); hydrolase (en); هيدروليز (ar); Hidrolaza (bs); hidrolizazo (eo) 加水分解反応の触媒とし

https://commons.wikimedia.org/wiki/Category:Hydrolases

Acrosin binding protein functions in the packing and storage of acrosin in the acrosome. Although acrosin is one of the major ... Acrosin-binding protein (Fragment). Sus scrofa. 81.2. 6 (4). M up regulated. 3.8. 69. ... Acrosin-binding protein. Homo sapiens. 41.6. 4 (2). M up regulated. 6.5. 50. ... Two different protein spots identified as acrosin binding protein were found to be in higher abundance in M sperm. ...

http://www.mdpi.com/1422-0067/14/8/15860/htm

Because two proteins, acrosin binding protein (ACRBP) and triosephosphate isomerase (TPI), presented the highest significant ... Acrosin-binding protein (ACRBP) and triosephosphate isomerase (TPI) aregood markers to predict boar sperm freezing capacity ... Acrosin-binding protein (ACRBP) and triosephosphate isomerase (TPI) aregood markers to predict boar sperm freezing capacity ... Because two proteins, acrosin binding protein (ACRBP) and triosephosphate isomerase (TPI), presented the highest significant ...

http://dugi.udg.edu/item/http:@@@@[email protected]@[email protected]@297724

Acrosin. Weak inhibition6. Chymotrypsin. Ki = 9 nM9. Chymotrypsinogen (bovine), pH 8.0. Ki = 9 nM4. ...

https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/enzyme-reagents/aprotinin.html

Full text: Available Index: WPRIM (Western Pacific) Main subject: Spermatozoa / Humans / Male / Acrosin / Fertilization in ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Spermatozoa / Humans / Male / Acrosin / Fertilization in ... Acrosin , Metabolism , Adult , Centrifugation, Density Gradient , Fertilization in Vitro , Humans , Male , Spermatozoa , Cell ... p,,b,OBJECTIVE,/b,To study the effect of Percoll selection technique on normal morphology and acrosin activity of human ...

https://search.bvsalud.org/gim/resource/en/wpr-357033

... and the activation of the boar proacrosin/acrosin system. The acrosomal membrane proteins of boar sperm for use in different ... Expression and tyrosine phosphorylation of sp32 regulate the activation of the boar proacrosin/acrosin system. * H.T. Dong ... and the activation of the boar proacrosin/acrosin system. The acrosomal membrane proteins of boar sperm for use in different ... and the activation of the boar proacrosin/acrosin system. The acrosomal membrane proteins of boar sperm for use in different ...

https://geneticsmr.com/articles/4126

Because two proteins, acrosin binding protein (ACRBP) and triosephosphate isomerase (TPI), presented the highest significant ... Acrosin-binding protein (ACRBP) and triosephosphate isomerase (TPI) are good markers to predict boar sperm freezing capacity. ... Acrosin-binding protein (ACRBP) and triosephosphate isomerase (TPI) are good markers to predict boar sperm freezing capacity. ... Because two proteins, acrosin binding protein (ACRBP) and triosephosphate isomerase (TPI), presented the highest significant ...

https://www.obs-gyn.ox.ac.uk/publications/512497

Acrosin is a typical serine proteinase with trypsin-like specificity. (wikipedia.org)
There exists a somewhat similar (27-35%) sequence identity between β-acrosin and other serine proteases such as trypsin and chymotrypsin. (wikipedia.org)
A gene on chromosome 4q12 that encodes a strong inhibitor of acrosin in the male and/or female genital tract, as well as a trypsin inhibitor. (thefreedictionary.com)
The antibody ACR-2 reacts with various forms of porcine acrosin (55, 53, 45 and 35 kDa), a typical serine proteinase with trypsin-like specificity. (exbio.cz)
1986) Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates. (guidetopharmacology.org)
The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. (nih.gov)
Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II). (nih.gov)
Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones. (nih.gov)

Acrosin is released from the acrosome of spermatozoa as a consequence of the acrosome reaction. (wikipedia.org)
The importance of acrosin in the acrosome reaction has been contested. (wikipedia.org)
In general, when spermatozoa reach the oocyte, they initiate the acrosome reaction and release an enzyme called acrosin , which degrades the oocyte ZP to allow spermatozoa to penetrate into the oocyte cytosol, where the fertilization is finally completed. (thefreedictionary.com)
Moos J, Peknicova J, Tesarik J. Relationship between molecular conversions of acrosin and the progression of exocytosis in the calcium ionophore-induced acrosome reaction. (exbio.cz)
Moos J, Peknicova J, Tesarik J. Protein-protein interactions controlling acrosin release and solubilization during the boar sperm acrosome reaction. (exbio.cz)
Capacitation is a set of alterations leading to the acrosome reaction (AR), an exocytotic process by means of which hydrolytic enzymes (e.g., acrosin) are released to allow sperm to fertilize oocytes [ 1 ]. (mdpi.com)

Proacrosin is first cleaved between Arg-22 and adjacent Valine to create a 22 residue light chain, and an active protease termed α-acrosin. (wikipedia.org)
This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. (wikipedia.org)
A basic 18-amino acid peptide contain the polysulfate-binding domail responsable for activation of the boar proacrosin/ acrosin system. (thefreedictionary.com)
Kennedy WP, Vander Ven HH, Straus JW, Bhattacharya AK, Waller DP, Zaneveld LJD, Polakoski KL (1983) Gossypol inhibition of acrosin and proacrosin and oocyte penetration by human spermatozoa. (thefreedictionary.com)
Demonstration of proacrosin and quantitation of acrosin in ejaculated human spermatazoa. (thefreedictionary.com)
May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. (mybiosource.com)
Also known as Acrosin-binding protein (Cancer/testis antigen 23) (CT23) (Cancer/testis antigen OY-TES-1) (Proacrosin-binding protein sp32). (mybiosource.com)
The current study investigated the relationship between the level of expression and tyrosine phosphorylation of the sperm protein 32 (sp32) and the activation of the boar proacrosin/acrosin system. (geneticsmr.com)
As a proacrosin binding protein, sp32 shows upregulated expression and increase in tyrosine phosphorylation levels during the activation of the boar proacrosin/acrosin system. (geneticsmr.com)

Under the secondary binding protein hypothesis, acrosin could serve a role in binding to molecules on the zona pellucida, tethering the spermatozoa to the egg. (wikipedia.org)
Acrosin regulation has been found to occur through protein C inhibitor (PCI). (wikipedia.org)
Acrosin binding protein is a protein that in humans is encoded by the ACRBP gene. (wikipedia.org)
Additionally we are shipping Acrosin Binding Protein Antibodies (24) and Acrosin Binding Protein Proteins (4) and many more products for this protein. (antibodies-online.com)
Below are the list of possible Acrosin-binding protein products. (mybiosource.com)
Because two proteins, acrosin binding protein (ACRBP) and triosephosphate isomerase (TPI), presented the highest significant differences between GFE and PFE groups in two-dimensional difference gel electrophoresis assessment, Western blot analyses for ACRBP and TPI were also performed for validation. (udg.edu)

Thus, PCI has been hypothesized to have a protective role: if acrosomal enzymes were released prematurely, or if the spermatozoa was degenerated within the male reproductive tract, the high concentrations of PCI would inhibit acrosin from inflicting proteolytic damage on nearby tissues. (wikipedia.org)
Acrosin , the most widely used acrosomal enzyme associated with the acrosome of all mammalian spermatozoa was assessed by the method of Bhattacharya and Zeneveld (1978), Bhattacharya et al. (thefreedictionary.com)
beta-acrosin is thought to be multifunctional with roles in acrosomal exocytosis, as a receptor for zona pellucida proteins, and as a protease to facilitate penetration of spermatozoa into the egg. (rcsb.org)
This result demonstrates that the enhancing effect of peroxidation on sperm-zona adhesion involves a direct action on the properties of the sperm-plasma membrane, rather than an indirect consequence of acrosomal damage and acrosin leakage. (nih.gov)
Objective: To determine the relationships between sperm acrosin activity, sperm morphology evaluated according to strict criteria, visually observed acrosomal morphology, and IVF rates. (sun.ac.za)

The microtiter plate provided in this kit has been pre-coated with an antibody specific to Acrosin (ACR). (biomatik.com)
Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Acrosin (ACR). (biomatik.com)
After TMB substrate solution is added, only those wells that contain Acrosin (ACR), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (biomatik.com)

Acrosin antibodies present in the sera of infertile women inhibit spermzona pellucida binding through protease activity (8). (thefreedictionary.com)

Acrosin inhibitor in extract of the zonae pellucidae of porcine oocytes. (uniprot.org)

Strong inhibitor of acrosin in male and/or female genital tract. (abcam.com)

Moos J, Tesarik J, Leca G, Peknicova J. Mechanism of maturation and nature of carbohydrate chains of boar sperm acrosin. (exbio.cz)
Boar and Human Acrosin and Acrosin Inhibitors. (uni-muenchen.de)

Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors. (uni-muenchen.de)

Background: Evaluation and comparison of total acrosin activity along with DNA integrity in the semen samples obtained from the varicocele individuals before and after the surgery and also in fertile individuals. (sid.ir)
Materials and Methods: Semen parameters, protamine deficiency, DNA fragmentation and Total acrosin activity were measured in patients with a clinical diagnosed varicocele of grade II or III varicocele men (n= 70) and fertile men as control group(n= 30). (sid.ir)
Effect of abstinence on sperm acrosin, hypoosmotic swelling, and other semen variables. (springer.com)
Effects of season and breed on sperm acrosin activity and semen quality of boars. (academicjournals.org)
Goodpasture, J.C., Zavos, P.M., Cohen, M.R. and Zaneveld, L.J.D.: Effects of various conditions of semen storage on the acrosin system of human spermatozoa. (zavos.org)

Functional Anatomy of Acrosin Inhibitors. (uni-muenchen.de)
Mammalian seminal acrosin inhibitors. (expasy.org)

Inhibits acrosin. (mybiosource.com)

Variants of human seminal acrosin inhibitor (HUSI-II) which inhibit human leukocyte elastase. (nih.gov)

The mechanism of action seems to be by disrupting the plasma membrane integrity as they caused drastic inhibition on sperm membrane specific enzymes like acrosin and 5' nuleotidase. (thefreedictionary.com)
The residual activity of acrosin was negatively correlated with the Nandeshi concentration, and Nandeshi exhibited an inhibition rate about 800 times that of TLCK . (bvsalud.org)

S1: Chymotrypsin: acrosin. (guidetopharmacology.org)

Our observation of a positive association with sperm DNA damage, as measured by Tail%, may also be consistent with previous reports that BP may be a suitable vaginal contraceptive because of its ability to inhibit acrosin (an enzyme that aids sperm penetration into the oocyte during the fertilization process), most likely by damaging the sperm membrane (Song et al. (thefreedictionary.com)

Acrosin is a digestive enzyme that acts as a protease. (wikipedia.org)
After this reaction occurs, the zymogen form of the protease is then processed into its active form, β-acrosin. (wikipedia.org)
It has been found through genetic knockout experiments that mouse spermatozoa lacking β-acrosin (the active protease) still have the ability to penetrate the zona pellucida. (wikipedia.org)
Acrosin is the major protease of mammalian spermatozoa. (uniprot.org)

This assay has high sensitivity and excellent specificity for detection of Acrosin (ACR). (biomatik.com)

In humans, acrosin is encoded by the ACR gene. (wikipedia.org)

Acrosin lyses the ovum's zona pellucida, facilitating sperm penetration through the innermost glycoprotein layers of the ovum. (thefreedictionary.com)

Spartiumjunceum Reduced rate of fertility and Broom acrosin enzyme activity. (thefreedictionary.com)

PCI has been demonstrated to inhibit the proteolytic activity of acrosin. (wikipedia.org)
Total acrosin activity assessed by spectrophotometery. (sid.ir)
Results: Total acrosin activity, percentage CMA3 positive, TUNEL positive sperm and abnormal morphology are higher in the varicocele individuals before the surgery compared to the fertile individuals, yet all the mentioned criteria decreased significantly after the surgery. (sid.ir)
However, Total acrosin activity was higher in these individuals and decreased to the value close to fertile control post-surgery. (sid.ir)
To evaluate the inhibitory effect of Nandeshi, an acrosin inhibitor, on human acrosin activity. (bvsalud.org)
Nandeshi has a powerful inhibitory effect on human acrosin , and improved Kennedy assay is a simple, practical and highly sensitive technique for the detection of human acrosin activity. (bvsalud.org)
To study the effect of Percoll selection technique on normal morphology and acrosin activity of human spermatoza. (bvsalud.org)
The sperm morphology and sperm acrosin activity were analyzed by automated sperm morphology analyzer(ASMA) and spectrocolorimetry. (bvsalud.org)
Percoll selection technique could affect normal morphology sperm ratio and acrosin activity. (bvsalud.org)
The sperm acrosin activity and by dartos skin closing, testes through the epididymis. (accap.org)

Release of acrosin and acrosin inhibitor from human spermatozoa. (thefreedictionary.com)

Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Acrosin (ACR) were tested 20 times on one plate, respectively. (biomatik.com)
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Acrosin (ACR) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)

Following these N-terminal cleavage events, three cleavages at the C-terminal domain removes 70 residues, yielding β-acrosin. (wikipedia.org)

In Eutheria n mammals the acrosome contains digestive enzyme s (including hyaluronidase and acrosin ). (academic.ru)

An important structural element of β-acrosin is a highly charged patch (formed through both amino acids and post-translational modifications) on its surface region, that has been termed the "anion binding exosite. (wikipedia.org)

indirectly protects component of the male genital tract from being degraded by excessive released acrosin. (genecards.org)

Anatomy5

Organisms2

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes3

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care1

Geographicals2

Changes in hyaluronidase, acrosin, and N-acetylhexosaminidase activities of dog sperm after incubation. (1/189)

Immunolocalization of CRES (Cystatin-related epididymal spermatogenic) protein in the acrosomes of mouse spermatozoa. (2/189)

Effect of recombinant boar beta-acrosin on sperm binding to intact zona pellucida during in vitro fertilization. (3/189)

Tissue-inherent fate of GPI revealed by GPI-anchored GFP transgenesis. (4/189)

Expression of human proacrosin in Escherichia coli and binding to zona pellucida. (5/189)

The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: structural alterations. (6/189)

A basic 18-amino acid peptide contains the polysulfate-binding domain responsible for activation of the boar proacrosin/acrosin system. (7/189)

Trypsin/acrosin inhibitor activity of rat and guinea pig caltrin proteins. Structural and functional studies. (8/189)

Acrosin

Spermatozoa

Acrosome

Enzyme Precursors

Zona Pellucida

Endopeptidases

Sperm-Ovum Interactions

Serine Endopeptidases

Acrosome Reaction

Molecular Sequence Data

Databases, Protein

Internet

User-Computer Interface

Sheep

Semen Preservation

B-Cell Maturation Antigen

Immune Sera

Goats

Tumor Necrosis Factor Ligand Superfamily Member 13

Transmembrane Activator and CAML Interactor Protein

B-Cell Activating Factor

alpha-L-Fucosidase

Microtubule Proteins

Sperm Maturation

Epididymis

Factor VIII

Counterfeit Drugs

Fraud

Reagent Kits, Diagnostic

China

Cambodia

Proto-Oncogene Proteins c-kit

Medicare Assignment

Two-Dimensional Difference Gel Electrophoresis

Triose-Phosphate Isomerase

Electrophoresis, Gel, Two-Dimensional

Cryopreservation

Proteomics

Proteome

Changes in hyaluronidase, acrosin, and N-acetylhexosaminidase activities of dog sperm after incubation. (1/189)

Immunolocalization of CRES (Cystatin-related epididymal spermatogenic) protein in the acrosomes of mouse spermatozoa. (2/189)

Effect of recombinant boar beta-acrosin on sperm binding to intact zona pellucida during in vitro fertilization. (3/189)

Tissue-inherent fate of GPI revealed by GPI-anchored GFP transgenesis. (4/189)

Expression of human proacrosin in Escherichia coli and binding to zona pellucida. (5/189)

The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: structural alterations. (6/189)

A basic 18-amino acid peptide contains the polysulfate-binding domain responsible for activation of the boar proacrosin/acrosin system. (7/189)

Trypsin/acrosin inhibitor activity of rat and guinea pig caltrin proteins. Structural and functional studies. (8/189)

Sperm-associated acrosin inhibitor elisa and antibody

ACR - Acrosin precursor - Homo sapiens (Human) - ACR gene & protein

Major Goat Sperm 105 kDa Maturation Antigen: Purification, Characterization, and Effect of Its Antiserum on Acrosin Activity -...

OriGene - Acrbp (NM 016845) cDNA Clone

Most Active Senior Online Dating Site Without Registration | VIDA LOOKA™

RCSB PDB - 1FIW: THREE-DIMENSIONAL STRUCTURE OF BETA-ACROSIN FROM RAM SPERMATOZOA

ACRBP polyclonal antibody - (PAB23394) - Products - Abnova

ON THE TERATOGENESIS OF ROUND-HEADED SPERMATOZOA - INVESTIGATIONS WITH ANTIBODIES AGAINST ACROSIN, AN INTRAACROSOMALLY LOCATED...

Acrosomal Vesicle Protein 1 (ACRV1) Antikörper

Rabbit Polyclonal to ACRBP | Emerging Understanding of Bcl-2 Biology

Tissue expression of ACRBP - Staining in small intestine - The Human Protein Atlas

Two black cocks and a wife - VideoSexArchive

Small Cock tube - GonzoXXX

anti-ACRV1 antibody, N-term | GeneTex

Lovehoney Mega Boost Vibrating Adjustable Cock Ring | Lovehoney UK

Staxus] Kurt Maddox enjoys a black double penetration courtesy of two monstrous uncut cocks! at dbNaked.com

How to Choose the Right Cock Ring

How many Freudians does it take to change a lightbulb? | MyConfinedSpace

Airway Trypsin-like Protease/HAT/TMPRSS11D Lysates: Novus Biologicals

boar sperm acidic arginine amidase-2 Summary Report | CureHunter

Acrosomal synonyms, acrosomal antonyms - FreeThesaurus.com

Rock Hard Cock Pipe | FetchShop

King Cock 6-Inch Squirting Cock | Lovers Lane

King Cock 5 Cock | Small realistic dildo | Light brown | 12 cm

Cock Rings | Buy High Quality Vibrating Cock Ring & Penis Ring - Diskrét

BrutalClips - Cock bigger than her forearm goes in to the balls

PROVALVE XL 3-WAY STOP COCK WITH EXTENSION LINE 1032 | at best price | medikabazaar.com

camera man gets in on hott cock action | Man Hub ™

Too big cock anal compilation

Teen, Miyu, craves for a big cock in her little vagina

Cock of the Walk, Enterprise - Restaurant Reviews & Photos - TripAdvisor

Hot fillipina takes vein cock Vídeos Porno - Tube8

Gentaur Molecular :Ato \ Buffer Inlet Cock \ 2393207

$Gentaur Molecular :Ato \ Buffer Inlet Cock \ 2393207$ Gentaur Molecular :Ato \ Buffer Inlet Cock \ 2393207