A trypsin-like enzyme of spermatozoa which is not inhibited by alpha 1 antitrypsin.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.
Physiologically inactive substances that can be converted to active enzymes.
A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
Interactive processes between the oocyte (OVUM) and the sperm (SPERMATOZOA) including sperm adhesion, ACROSOME REACTION, sperm penetration of the ZONA PELLUCIDA, and events leading to FERTILIZATION.

Changes in hyaluronidase, acrosin, and N-acetylhexosaminidase activities of dog sperm after incubation. (1/189)

Hyaluronidase, acrosin and N-acetylhexosaminidase activities were examined in sperm collected from 12 beagle dogs and in culture medium after 0.5 hr and 7 hr of sperm incubation. The activities of the three enzymes were significantly higher at 7 hr than at 0.5 hr (P < 0.05, 0.01), and the increases were associated with sperm capacitation. It was considered that the three enzymes in the dog sperm are related to fertilization by reason of the findings of the release of these enzymes from the sperm into the medium after 7 hr of incubation.  (+info)

Immunolocalization of CRES (Cystatin-related epididymal spermatogenic) protein in the acrosomes of mouse spermatozoa. (2/189)

The CRES (cystatin-related epididymal spermatogenic) protein is a member of the cystatin superfamily of cysteine protease inhibitors and exhibits highly restricted expression in the reproductive tract. We have previously shown that CRES protein is present in elongating spermatids in the testis and is synthesized and secreted by the proximal caput epididymal epithelium. The presence of CRES protein in developing germ cells and in the luminal fluid surrounding maturing spermatozoa prompted us to examine whether CRES protein is associated with spermatozoa. In the studies presented, indirect immunofluorescence, immunogold electron microscopy, and Western blot analysis demonstrated that CRES protein is localized in sperm acrosomes and is released during the acrosome reaction. Interestingly, while the 19- and 14-kDa CRES proteins were present in testicular and proximal caput epididymal spermatozoa, the 14-kDa CRES protein was the predominant form present in mid-caput to cauda epididymal spermatozoa. Furthermore, following the ionophore-induced acrosome reaction, CRES protein localization was similar to that of proacrosin/acrosin in that it was detected in the soluble fraction as well as associated with the acrosome-reacted spermatozoa. The presence of CRES protein in the sperm acrosome, a site of high hydrolytic and proteolytic activity, suggests that CRES may play a role in the regulation of intraacrosomal protein processing or may be involved in fertilization.  (+info)

Effect of recombinant boar beta-acrosin on sperm binding to intact zona pellucida during in vitro fertilization. (3/189)

In a previous paper we demonstrated that boar beta-acrosin recombinant proteins were able to bind non-enzymatically to solubilized pig zona pellucida (ZP) glycoproteins. Here we report the participation of boar beta-acrosin in the secondary binding of sperm to intact pig ZP. This was achieved by using two boar recombinant proteins: beta-acrosin and a mutant of the catalytic site, beta-acrosin Ser/Ala(222). Assays of binding between the iodinated recombinant beta-acrosin and whole ZP showed that this binding could be saturated, was specific, and was stable over time. Using autoradiography, we determined that recombinant beta-acrosin bound on the entire surface of the ZP but initially was distributed heterogeneously. This suggests that the ligands for beta-acrosin may not be homogeneously distributed on the ZP. To study the contribution of acrosin in sperm secondary binding to the ZP, we preincubated in vitro-matured oocytes with these recombinant proteins and then performed in vitro fertilization assays. Under the experimental conditions used, binding of beta-acrosin recombinant proteins did not block sperm penetration. These results suggest that there may be other proteins that participate in the secondary binding, and that these proteins may recognize ligands that are different from those blocked by beta-acrosin recombinant proteins.  (+info)

Tissue-inherent fate of GPI revealed by GPI-anchored GFP transgenesis. (4/189)

To clarify the fate of glycosylphosphatidylinositol (GPI) in mammals, we developed GPI-anchored enhanced green fluorescent protein (EGFP-GPI) and transgenic mice carrying this fusion construct. When it was introduced to culture cells, the EGFP-GPI protein was correctly sorted to plasma membranes and microsomes depending on GPI biosynthesis. Transgenic mice carrying EGFP-GPI were found to show a broad transgene expression. Histologically, a prominent polarized localization of EGFP-GPI protein was observed in various epithelia, the nervous system and liver and secreted from some exocrine glands, as well as non-polarized presence in non-epithelial tissues, demonstrating a tissue-inherent manner of GPI sorting.  (+info)

Expression of human proacrosin in Escherichia coli and binding to zona pellucida. (5/189)

Proacrosin is a multifunctional protein present in the sperm acrosome. This study characterizes the expression of human proacrosin in bacteria and assesses zona pellucida binding activity. The cDNA encoding human proacrosin was subcloned in pGEX-3X and pET-22b vectors. In the pGEX system, expression of the full-length fusion protein was not detected. In the pET system, an expression product with an apparent molecular size similar to that expected for the proenzyme (Rec-40, 42-44 kDa) was recognized by a monoclonal antibody to human acrosin, AcrC5F10. A 32-34-kDa protein (Rec-30), not recognized by AcrC5F10 on Western blots, was the major expression product. Proteins of 21 (Rec-20) and 18 (Rec-10) kDa were recovered as insoluble expression products as were Rec-40 and Rec-30, and truncated products from the C terminus were detected in the soluble fraction. Rec-40 and Rec-30 coexisted at any culture time tested. Immune serum raised against Rec-30 (AntiRec-30) stained the acrosomal region of permeabilized human spermatozoa and recognized the recombinant proteins and proacrosin from human sperm extracts. Amino acid sequence analysis indicated that Rec-30, Rec-20, and Rec-10 are N-terminal fragments of proacrosin. The recombinant proteins Rec-40, -30, -20, and -10 were found to interact with homologous (125)I-zona pellucida glycoproteins.  (+info)

The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: structural alterations. (6/189)

The acrosome is an acidic secretory vesicle containing hydrolytic enzymes that are involved in the sperm's passage across the zona pellucida. Imaging of the acrosomal vesicle and the Golgi apparatus in live rhesus monkey spermatids was accomplished by using the vital fluorescent probe LysoTracker DND-26. Concurrently, the dynamics of living spermatid mitochondria was visualized using the specific probe MitoTracker CMTRos and LysoTracker DND-26 detected the acrosomal vesicle from its formation through spermatid differentiation. LysoTracker DND-26 also labeled the Golgi apparatus in spermatogenic cells. In spermatocytes the Golgi is spherical and, in round spermatids, it is localized over the acrosomal vesicle, as confirmed by using polyclonal antibodies against Golgin-95/GM130, Golgin-97, and Golgin-160. Using both live LysoTracker DND-26 imaging and Golgi antibodies, we found that the Golgi apparatus is cast off from the acrosomal vesicle and migrates toward the sperm tail in elongated spermatids. The Golgi is discarded in the cytoplasmic droplet and is undetectable in mature ejaculated spermatozoa. The combined utilization of three vital fluorescent probes (Hoechst 33342, LysoTracker DND-26, and MitoTracker CMTRos) permits the dynamic imaging of four organelles during primate spermiogenesis: the nucleus, the mitochondria, the acrosomal vesicle, and the Golgi apparatus.  (+info)

A basic 18-amino acid peptide contains the polysulfate-binding domain responsible for activation of the boar proacrosin/acrosin system. (7/189)

Proacrosin is the zymogen of acrosin, a serine protease localized in the acrosomal matrix of mammalian sperm. Proacrosin/acrosin binds to solubilized zona pellucida glycoproteins (ZPGs) and various polysulfates in a non-enzymatic mechanism. In addition, both polysulfates and ZPGs induce proacrosin activation once they bind to the polysulfate-binding domain (PSBD) of the enzyme. We show here that the peptide (43)IFMYHNNRRYHTCGGILL(60) inhibited the proacrosin activation induced by either fucoidan or ZPGs. In addition, the peptide was recognized by the monoclonal antibody C5F10, which is directed against the PSBD region. Our data suggest that the PSBD is composed of many "subsites" that may or may not interact with each other.  (+info)

Trypsin/acrosin inhibitor activity of rat and guinea pig caltrin proteins. Structural and functional studies. (8/189)

Dramatic inhibition of trypsin activity by rat caltrin and guinea pig caltrin I was spectrophotometrically demonstrated using the artificial substrate benzoylarginyl ethyl ester. Approximately 6% and 21% of residual proteolytic activity was recorded after preincubating the enzyme with 0.22 and 0.27 microM rat caltrin and guinea pig caltrin I, respectively. Reduction and carboxymethylation of the cysteine residues abolished the inhibitor activity of both caltrin proteins. Rat caltrin and guinea pig caltrin I show structural homology with secretory trypsin/acrosin inhibitor proteins isolated from boar and human seminal plasma and mouse seminal vesicle secretion and share a fragment of 13 amino acids of almost identical sequence (DPVCGTDGH/K/ITYG/AN), which is also present in the structure of Kazal-type trypsin inhibitor proteins from different mammalian tissues. Bovine, mouse, and guinea pig caltrin II, three caltrin proteins that have no structural homology with rat caltrin or guinea pig caltrin I, lack trypsin inhibitor activity. Rat caltrin, guinea pig caltrin I, and the mouse seminal vesicle trypsin inhibitor protein P12, which also inhibits Ca(2+) uptake into epididymal spermatozoa (mouse caltrin I), bound specifically to the sperm head, on the acrosomal region, as detected by indirect immunofluorescence. They also inhibited the acrosin activity in the gelatin film assay. Caltrin I may play an important role in the control of sperm functions such as Ca(2+) influx in the acrosome reaction and activation of acrosin and other serine-proteases at the proper site and proper time to ensure successful fertilization.  (+info)

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Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
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FLORKEGERLOFF S, KRAUSE W, TOPFERPETERSEN E, Tschesche H, MULLERESTERL W, ENGEL W. ON THE TERATOGENESIS OF ROUND-HEADED SPERMATOZOA - INVESTIGATIONS WITH ANTIBODIES AGAINST ACROSIN, AN INTRAACROSOMALLY LOCATED ACROSIN-INHIBITOR, AND THE OUTER ACROSOMAL MEMBRANE. ANDROLOGIA. 1985;17(2):126-138 ...
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Hematopoietic stem-cell transplantation (HSCT) is normally the many powerful healing therapy for many cancerous and nonmalignant disorders. potent in causing and aggravating the GVHD response. In this review, we showcase the function of these tissues damaging elements and their signaling paths. Remarkably, some PAMPs and DAMPs are organ particular and GVHD-induced and possess been shown to be interesting biomarkers. Some of these elements may represent potential goals for story therapeutic techniques. colonies in newborns via disruption of the homeostasis between the digestive tract microbiome and web host defenses (47). No research have got proven the influence of this family members in Rabbit Polyclonal to ACRBP GVHD however, but all of the above results recommend that these DAMPs may perform a part in different types of cells harm and the pathology of pores and skin and GI GVHD. Furthermore, proteomic evaluation of saliva demonstrated that healthful settings possess low or non-detectable ...
Expression of ACRBP (CT23, OY-TES-1, SP32) in small intestine tissue. Antibody staining with HPA039081 and HPA039082 in immunohistochemistry.
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boar sperm acidic arginine amidase-2: activity is independent of calcium chloride concentration; see also acidic arginine amidase-1, boar sperm
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FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008 ...
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... acrosin inhibitor; and elastase inhibitor. These proteins contain between 1 and 7 Kazal-type inhibitor repeats. The structure ...
Acrosin digests the zona pellucida and membrane of the oocyte. Part of the sperm's cell membrane then fuses with the egg cell's ... In mammals, the acrosome reaction releases hyaluronidase and acrosin; their role in fertilization is not yet clear. The ... by releasing hyaluronidase from the acrosome to digest cumulus cells surrounding the oocyte and exposing acrosin attached to ...
Evidence for the presence of spermosin, a novel acrosin-like enzyme". The Journal of Biological Chemistry. 259 (5): 2900-4. ... Sawada H, Someno T (October 1996). "Substrate specificity of ascidian sperm trypsin-like proteases, spermosin and acrosin". ... spermosin and acrosin, in fertilization of the ascidian, Halocynthia roretzi: inhibitory effects of leupeptin analogs on enzyme ...
Furlong LI, Harris JD, Vazquez-Levin MH (2005). "Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) ...
Furlong LI, Harris JD, Vazquez-Levin MH (2006). "Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) ...
Furlong LI, Harris JD, Vazquez-Levin MH (Jun 2005). "Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) ...
In placental mammals the acrosome contains degradative enzymes (including hyaluronidase and acrosin). These enzymes break down ...
Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the ... Moritz A, Grzeschik KH, Wingender E, Fink E (Mar 1993). "Organization and sequence of the gene encoding the human acrosin- ... Fink E, Hehlein-Fink C, Eulitz M (1990). "Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals ... Möritz A, Lilja H, Fink E (1991). "Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin ...
... has a role in reproduction as it has ability to inhibit the sperm protease acrosin. Large amounts of ... Zheng X, Geiger M, Ecke S, Bielek E, Donner P, Eberspächer U, Schleuning WD, Binder BR (August 1994). "Inhibition of acrosin by ...
B. bimaculatus venom contains additional proteins, including acrosin and a tryptic amidase related to clotting enzymes. ...
This in turn causes both acrosin and hyaluronidase enzymes to leak out of the sperm, making the sperm infertile. The safety of ...
C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochimica et Biophysica Acta (BBA) - Protein Structure and ...
... acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play ...
... acrosin - actin - action potential - activation energy - active site - active transport - adenosine - adenosine diphosphate ( ...
... may refer to: Albumin/creatinine ratio in urine ACR score for rheumatoid arthritis ACR gene, encoding the enzyme acrosin ...
Acrosin (EC 3.4.21.10) Factor VII (EC 3.4.21.21) Factor IX (EC 3.4.21.22) Prolyl oligopeptidase (EC 3.4.21.26) Factor XI (EC ...
... acrosin MeSH D08.811.277.656.300.760.176 - chymotrypsin MeSH D08.811.277.656.300.760.198 - complement factor b MeSH D08.811. ...
... or acrosin), that is necessary for fertilization. As the spermatozoon approaches the egg, it undergoes the acrosome reaction in ...
... acrosin EC 3.4.21.11: Now EC 3.4.21.37, leukocyte elastase EC 3.4.21.12: α-lytic endopeptidase EC 3.4.21.13: Now EC 3.4.16.6, ... acrosin EC 3.4.21.11: Now EC 3.4.21.37, leukocyte elastase EC 3.4.21.12: α-lytic endopeptidase EC 3.4.21.13: Now EC 3.4.16.6, ...
... is a digestive enzyme that acts as a protease. In humans, acrosin is encoded by the ACR gene. Acrosin is released from ... the high concentrations of PCI would inhibit acrosin from inflicting proteolytic damage on nearby tissues. β-acrosin ... Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is stored in the acrosome in its precursor ... Acrosin regulation has been found to occur through protein C inhibitor (PCI). PCI is present in the male reproductive tract at ...
... is a protein that in humans is encoded by the ACRBP gene. The protein encoded by this gene is similar ... "Entrez Gene: Acrosin binding protein". Retrieved 2016-08-01. Okumura H, Noguchi Y, Uenaka A, Aji T, Ono T, Nakagawa K, Aoe M, ... the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin ...
Acrosin is a digestive enzyme that acts as a protease. In humans, acrosin is encoded by the ACR gene. Acrosin is released from ... the high concentrations of PCI would inhibit acrosin from inflicting proteolytic damage on nearby tissues. β-acrosin ... Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is stored in the acrosome in its precursor ... Acrosin regulation has been found to occur through protein C inhibitor (PCI). PCI is present in the male reproductive tract at ...
Behind the Scenes: Creating Acrosin. Posted bykaestlecastle August 30, 2022. August 30, 2022. Leave a comment on Behind the ... This week Duke and Kaestle take you through the process of creating Acrosin: The Game. IT LAUNCHES AT 12:00/noon PST time so ... Scenes: Creating Acrosin https://media.blubrry.com/themode/p/content.blubrry.com/themode/The_birth_of_Acrosin-8_30_22_11_53_AM. ...
Solid Phase BAPNA Method For Spermatozoa Acrosin Activity Quantitative Test products. ... Solid Phase BAPNA Method For Spermatozoa Acrosin Activity Quantitative Test from China, Chinas leading Male Fertility Test Kit ... SpermFunc Kits / Solid Phase BAPNA Method For Spermatozoa Acrosin Activity Quantitative Test. ...
Acrosin Antibody. NBP2-14260. Rabbit Polyclonal Species Human, Mouse, Rat. Applications ICC/IF, IHC, IHC-P ...
PubMed:Identification of the second form of acrosin in Turkey spermatozoa.. PubMed:Proteomic analysis on acetate metabolism in ...
Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors. Protides of the biological Twenty-Third ...
Acrosin activity of human sperm did not correlate with IVF. Yang, Y. S., Chen, S. U., Ho, H. N., Chen, H. F., Lien, Y. R., Lin ...
acrosin Show summary »« Hide summary More detailed page Target Id. 2327 Nomenclature. acrosin ...
Ecuador Consumer Price Index (CPI): Health: ME: PP: VM: Acrosin-B (2004=100) 95.14 Dec 2014 monthly Jan 2005 - Dec 2014 ...
Acrosin (substance). Code System Preferred Concept Name. Acrosin (substance). Concept Status. Published. ...
The positive rate of acrosin and in vitro incidence of acrosome reaction are reported to be significantly lower in rat sperms ...
Description: A sandwich ELISA for quantitative measurement of Mouse Anti acrosin antibodies in samples from blood, plasma, ... Description: A sandwich ELISA for quantitative measurement of Mouse Anti acrosin antibodies in samples from blood, plasma, ... Description: A sandwich ELISA for quantitative measurement of Mouse Anti acrosin antibodies in samples from blood, plasma, ...
Acrosin activity in pelleted frozen sperm does not correlate with in vitro fertilization of oocytes. 28:349-352. 1996 ...
Description: A sandwich ELISA for quantitative measurement of Goat Anti acrosin antibodies in samples from blood, plasma, serum ... Description: A sandwich ELISA for quantitative measurement of Goat Anti acrosin antibodies in samples from blood, plasma, serum ... Description: A sandwich ELISA for quantitative measurement of Goat Anti acrosin antibodies in samples from blood, plasma, serum ...
... acrosin 3.4.21.11 Transferred entry: 3.4.21.36 and 3.4.21.37 3.4.21.12 alpha-lytic endopeptidase 3.4.21.13 Transferred entry: ...
Avian acrosin: the relationship between biological role and specificity. Milne, F. C., Wishart, G. J., Robertson, L. & Horrocks ...
acrosin [Source:HGNC Symbol;Acc:HGNC.... ACSL1. 2180. ACSL1. acyl-CoA synthetase long chain famil.... ...
acrosin. chr6_+_108616243. 0.15. ENST00000421954.1. LACE1. lactation elevated 1. chr9_+_44868935. 0.15. ENST00000448436.2. RP11 ...
Synthesized peptide derived from the N-terminal region of human Acrosin.. Host Species:. Rabbit. ...
acrosin prepropeptide. 0.015. Rgs6. regulator of G-protein signaling 6. 0.015. Tacr2. tachykinin receptor 2. 0.015. ...
Epiluts analysis of human anatomy, ed 3, plates 184 and 266.) table 6.4 muscles of the disorder and low acrosin activity and ...
acrosin. 0.048. Lim2. lens intrinsic membrane protein 2. 0.046. Ush1c. Usher syndrome 1C homolog (human). 0.046. ...
acrosin Synonyms Species Homo sapiens Ensembl Protein ENSP00000435120 InnateDB Gene IDBG-14292 (ACR) ...
Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/ acrosin in women consulting for infertility ... Acrosin antibodies present in the sera of infertile women inhibit spermzona pellucida binding through protease activity (8).. ...
Sperm acrosin in infertile men. An immunohistochemical study 47 Seminal macrophages in ejaculates from men with couple ... Impaired hamster egg penetration by human sperm from ejaculates with low acrosin activity but otherwise normal 49 ... A prospective analysis of the accuracy of the TEST-yolk buffer enhanced hamster egg penetration test and acrosin activity in ... Sperm-zona pellucida binding of human sperm is correlated with the immunocytochemical presence of proacrosin and acrosin in the ...
4e). Furthermore, the C1, but not the C2, expressed the sperm-specific markers Acrosin and Gsg2 after induction (Fig. 4f). ...
acrosin binding protein [S.... ACTR3B. 57180. ACTR3B. actin related protein 3B [.... AGPAT9. 84803. GPAT3. glycerol-3-phosphate ...
  • Description: A sandwich ELISA for quantitative measurement of Mouse Anti acrosin antibodies in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (automatyka-robotyka.pl)
  • Acrosin antibodies present in the sera of infertile women inhibit spermzona pellucida binding through protease activity (8). (jri.ir)
  • Mobile phone radiation reduces sperm motility, perm linear velocity, sperm linearity index, and sperm acrosin activity and increases DNA fragmentation in vitro. (greenmedinfo.com)
  • Before and immediately after exposure, both aliquots were subjected to different assessments for sperm motility, acrosin activity, sperm DNA fragmentation and CLU gene expression. (greenmedinfo.com)
  • Cell phone emissions have a negative impact on exposed sperm motility index, sperm acrosin activity, sperm DNA fragmentation and seminal CLU gene expression, especially in OAT cases. (greenmedinfo.com)
  • The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K. (scu.edu.cn)
  • Comparison between near and yet purported to think this is not normally exceed advise surgical intervention along with the sperm acrosin activity is not. (gatech.edu)
  • In one trial , researchers found that L-carnitine supplementation was associated with improved motility and increased activity of acrosin, an enzyme at the tip of sperm that helps it penetrate the egg for fertilization. (juohco.com)
  • The sperm binds to the zona pellucida of the secondary oocyte arrested in metaphase of meiosis II and triggers the acrosome reaction, causing the release of acrosomal enzymes (e.g., acrosin). (epomedicine.com)
  • Acrosin is released from the acrosome of spermatozoa as a consequence of the acrosome reaction. (wikipedia.org)
  • The importance of acrosin in the acrosome reaction has been contested. (wikipedia.org)
  • Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors. (uni-muenchen.de)
  • Acrosin is a typical serine proteinase with trypsin-like specificity. (wikipedia.org)
  • There exists a somewhat similar (27-35%) sequence identity between β-acrosin and other serine proteases such as trypsin and chymotrypsin. (wikipedia.org)
  • Thus, PCI has been hypothesized to have a protective role: if acrosomal enzymes were released prematurely, or if the spermatozoa was degenerated within the male reproductive tract, the high concentrations of PCI would inhibit acrosin from inflicting proteolytic damage on nearby tissues. (wikipedia.org)
  • Acrosin is a digestive enzyme that acts as a protease. (wikipedia.org)
  • After this reaction occurs, the zymogen form of the protease is then processed into its active form, β-acrosin. (wikipedia.org)
  • It has been found through genetic knockout experiments that mouse spermatozoa lacking β-acrosin (the active protease) still have the ability to penetrate the zona pellucida. (wikipedia.org)
  • Proacrosin is first cleaved between Arg-22 and adjacent Valine to create a 22 residue light chain, and an active protease termed α-acrosin. (wikipedia.org)
  • Acrosin is the major proteinase present in the acrosome of mature spermatozoa. (wikipedia.org)
  • PCI has been demonstrated to inhibit the proteolytic activity of acrosin. (wikipedia.org)
  • table 6.4 muscles of the disorder and low acrosin activity and its medical and psychosocial correlates: Results of a defined ielt threshold necessary to increase hematocrit levels described testosterone levels, which are posterior wall: Subscapularis, teres major, pectoralis major, and latissimus dorsi muscles. (psm.edu)
  • Relationship of seminal acrosin cytokines in 40:1139 1075. (gatech.edu)
  • Serpin-A5 forms a complex with kallikrein-3 in seminal plasma, but the chief target there is thought to be acrosin, although kallikrein-2 is also found in seminal fluid, and serpin-A5 was identified as a chief substrate by phage display. (triplepointbiologics.com)
  • Under the secondary binding protein hypothesis, acrosin could serve a role in binding to molecules on the zona pellucida, tethering the spermatozoa to the egg. (wikipedia.org)
  • co‐immunoprecipitation revealed interactions of testisin with a multitude of zona pellucida‐binding proteins, including ZPBP, ZAN, acrosin, several heat‐shock proteins, and components of the TCP1 complex. (edu.au)
  • Synthesized peptide derived from the N-terminal region of human Acrosin. (afgsci.com)
  • Heparin and other polyanion binding increases the serpin-A5 efficacy against acrosin approximately 100-fold and calcium binding is required for maximal inhibition. (triplepointbiologics.com)
  • An important structural element of β-acrosin is a highly charged patch (formed through both amino acids and post-translational modifications) on its surface region, that has been termed the "anion binding exosite. (wikipedia.org)