Acrodynia: A condition seen primarily in childhood, most often resulting from chronic exposure to MERCURY COMPOUNDS which may result in encephalopathy and POLYNEUROPATHY. Clinical features include pain, swelling and pinkish discoloration of the fingers and toes, weakness in the extremities, extreme irritability, HYPERESTHESIA, and alterations in level of consciousness. (From Menkes, Textbook of Child Neurology, 5th ed, p603)Photophobia: Abnormal sensitivity to light. This may occur as a manifestation of EYE DISEASES; MIGRAINE; SUBARACHNOID HEMORRHAGE; MENINGITIS; and other disorders. Photophobia may also occur in association with DEPRESSION and other MENTAL DISORDERS.Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.Thermometers: Measuring instruments for determining the temperature of matter. Most thermometers used in the field of medicine are designed for measuring body temperature or for use in the clinical laboratory. (From UMDNS, 1999)Mercury PoisoningMercury Compounds: Inorganic compounds that contain mercury as an integral part of the molecule.Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.Unithiol: A chelating agent used as an antidote to heavy metal poisoning.Diffusion Magnetic Resonance Imaging: A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Technetium Tc 99m Dimercaptosuccinic Acid: A nontoxic radiopharmaceutical that is used in the diagnostic imaging of the renal cortex.Chelating Agents: Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.Calcaneus: The largest of the TARSAL BONES which is situated at the lower and back part of the FOOT, forming the HEEL.Rickets: Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Diet, Sodium-Restricted: A diet which contains very little sodium chloride. It is prescribed by some for hypertension and for edematous states. (Dorland, 27th ed)Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Ophthalmoscopy: Examination of the interior of the eye with an ophthalmoscope.Supination: Applies to movements of the forearm in turning the palm forward or upward. When referring to the foot, a combination of adduction and inversion movements of the foot.Physical Exertion: Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.Lasers: An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Dyspnea: Difficult or labored breathing.Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Mucuna: A plant genus of the family FABACEAE that is the source of mucuna gum.Back Pain: Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.Cranial Nerve Diseases: Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.Cranial Nerves: Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.Abducens Nerve Diseases: Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.Oculomotor Nerve Diseases: Diseases of the oculomotor nerve or nucleus that result in weakness or paralysis of the superior rectus, inferior rectus, medial rectus, inferior oblique, or levator palpebrae muscles, or impaired parasympathetic innervation to the pupil. With a complete oculomotor palsy, the eyelid will be paralyzed, the eye will be in an abducted and inferior position, and the pupil will be markedly dilated. Commonly associated conditions include neoplasms, CRANIOCEREBRAL TRAUMA, ischemia (especially in association with DIABETES MELLITUS), and aneurysmal compression. (From Adams et al., Principles of Neurology, 6th ed, p270)Cranial Nerve Injuries: Dysfunction of one or more cranial nerves causally related to a traumatic injury. Penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA; NECK INJURIES; and trauma to the facial region are conditions associated with cranial nerve injuries.Facial Paralysis: Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis.ConjunctivitisFood Hypersensitivity: Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.Peak Expiratory Flow Rate: Measurement of the maximum rate of airflow attained during a FORCED VITAL CAPACITY determination. Common abbreviations are PEFR and PFR.Abdomen, Acute: A clinical syndrome with acute abdominal pain that is severe, localized, and rapid in onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.Abdomen: That portion of the body that lies between the THORAX and the PELVIS.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Burning Mouth Syndrome: A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.Pruritus Vulvae: Intense itching of the external female genitals.Sensation: The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.Face: The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw.Blister: Visible accumulations of fluid within or beneath the epidermis.Eyebrows: Curved rows of HAIR located on the upper edges of the eye sockets.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.Heart: The hollow, muscular organ that maintains the circulation of the blood.Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)

Mercury poisoning: a rare but treatable cause of failure to thrive and developmental regression in an infant. (1/3)

An infant presented with failure to thrive and developmental regression. Physical examination revealed an irritable child with swollen, erythematous extremities, and elevated blood pressure. Extensive investigations, including a metabolic work-up and neuroimaging, were unrevealing. Exposure to self-purchased medication was initially denied. The physical signs were suggestive of acrodynia. Mercury poisoning was ultimately established by measuring paired blood and urine mercury levels. On further enquiry, it was revealed that the child had been given a Chinese medicinal product for 4 months. He responded well to a chelating agent. Acrodynia is a childhood disease considered to be of historical interest only, but making a diagnosis of mercury poisoning is rewarding because the response to treatment is good. This case highlights the common misconception that alternative medicines are safe and benign.  (+info)

Ancestry of pink disease (infantile acrodynia) identified as a risk factor for autism spectrum disorders. (2/3)

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Mercury as a health hazard. (3/3)

Pink disease has virtually disappeared since teething powders were withdrawn. We describe a case in a boy who was exposed to metallic mercury vapour. We discuss the potential health hazard of spilled elemental mercury in the house and the difficulties of removing it from the environment.  (+info)

Acrodynia is characterized by pink discoloration of the hands and feet, irritability, photophobia (sensitivity to light) and polyneuritis (inflamed nerves). It is caused by chronic exposure to mercury. The most common form of exposure in young children is ingesting mercury from a broken thermometer. The signs and symptoms of mercury toxicity may not appear until weeks or months after exposure has occurred. ...
A condition seen primarily in childhood, most often resulting from chronic exposure to mercury compounds which may result in encephalopathy and polyneuropathy.
INTRODUCTION. The detection of heavy metals in polluted environments is an ever-growing concern and is the subject of ongoing research in various research groups. Of the toxic heavy metals, mercury is one of the highly toxic, leading to diseases such as acrodynia (pinks disease), Hunter-Russell syndrome and Minamata disease (Fujiki and Tajima, 1992; He et al., 2009; Kudo et al., 1988). Health problems associated with mercury are made worse due to its accumulative and persistent nature in the environment and in living organisms. Mercury is released into water by industrial processes such as coal burning and natural causes like volcanic eruptions (Yari and Papi, 2009). South Africa has been reported as the second highest emitter (50 t-year-1) of Hg in the world, after China (Pacyna et al., 2006), even though later estimates dispute this high emission rate and place emissions in the range of 2.6-17.6 t-year-1 (Dabrowski et al., 2008). South Africa is the third-largest coal producer in the world, ...
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Looking for Pink's disease? Find out information about Pink's disease. tissue damage resulting from exposure to more than trace amounts of the element mercury mercury or quicksilver , metallic chemical element; symbol Hg ; at.... Explanation of Pink's disease
Dr. Phillips has often suggested that I be a stay at home Mom with Jenelle. We talked about this and I asked him directly if he was keeping something from us. He said he wasnt keeping anything from us, but felt that some kids do better with the one on one attention. We then talked about Jenelles developmental regression. He is very worried about this, and feels that she is going in the wrong direction. Jenelles PT has noted that she is weak on her right side, and Ive noticed that she is no longer rolling from tummy to back, something she used to do with ease. This could be because of the grand mals, or because Jenelle has an undiagnosed degenerative neurological condition. The later of course is the worst case scenario, but it does mean that if her condition is degenerative, she will regress until she dies. He said we werent there yet, but he is concerned because she is regressing, and since we dont have a diagnosis, this (the degenerative neurological condition) is not something we can ...
MalaCards based summary : Salt and Pepper Syndrome, also known as salt-and-pepper syndrome, is related to salt and pepper developmental regression syndrome and cohen syndrome. An important gene associated with Salt and Pepper Syndrome is B3GNT5 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 5), and among its related pathways/superpathways are Metabolism and Synthesis of substrates in N-glycan biosythesis. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2) ...
Retts syndrome is a severe neurological disorder occurring mostly in girls. It is a type of autism spectrum disorder. It is a very serious disorder which leads to a developmental regression. The treatment for Retts syndrome lies in different therapies. Read on to know more.
Self-referral on The idea of one or more of the indicators of gastrointestinal troubles, developmental regression and an Affiliation with environmental publicity... Q: I asked you why you didnt help it become very clear, as We now have found with the letters that we checked out yesterday, that, at the least during the vast majority of cases, these small children came to begin with simply because their dad and mom believed that MMR experienced prompted that problem. You promptly to go a line in which you mention self-referral, but that particular reference would not incorporate the incredibly place that I am asking about, therefore you say is implicit, specifically the association with MMR. So how exactly does any reader, irrespective of whether a scientist, health practitioner or or else, read that into Whatever you say there? A: The patients, kids, are self-referred centered on dig this their signs or symptoms as well as their background. Which contains the 3 crucial things of the ...
Self-referral on The premise of a number hop over to here of on the indications of gastrointestinal troubles, developmental regression and an association with environmental exposure... Q: I questioned you why you did not enable it to be obvious, as Weve got found from your letters that we looked at yesterday, that, at the least in the vast majority of cases, these young children came in the first place mainly because their mom and dad imagined that MMR had prompted that situation. You right away to go a line where you take a look at self-referral, but that particular reference would not include things like the extremely point that im inquiring about, so you say is implicit, namely the association with MMR. How does any reader, no matter whether a scientist, physician or normally, browse that into Anything you say there? A: The sufferers, youngsters, are self-referred dependent on their own signs and symptoms as well as their historical past. That contains the three vital features of the ...
After recovering from a sickness that would bring him to the edge of despair, Eric Gladen began researching the science behind what had made him so sick. His research led him straight into one of the biggest medical debates of all time, the question of whether or not childhood vaccines are causing Autism. He would end up quitting his career, moving into an RV, and traveling the country interviewing experts and piecing together thousands of studies and leaked documents. But Eric wasn t focused on the vaccines themselves, he was focused on something that belongs nowhere near vaccines- mercury.. From the Mad Hatter Syndrome in the late 1800 s, to Pink Disease in the first half of the 20th century, humans have learned time and again of the debilitating neurological and physical damage that mercury can cause. Then why and how did it end up in our childhood vaccines? Trace Amounts explores the origin of the use of mercury in the vaccines and exposes the continued greed based decision to keep mercury ...
Rett syndrome is a neurodevelopmental disorder caused by a mutation in the X-linked MECP2 gene. Individuals with Rett syndrome typically develop normally until around 18 months of age before undergoing a developmental regression, and the disorder can lead to cognitive, motor, sensory, and autonomic dysfunction. Understanding the mechanism of developmental regression represents a unique challenge when viewed through a neuroscience lens. Are circuits that were previously established erased, and are new ones built to supplant old ones? One way to examine circuit-level changes is with the use of electroencephalography (EEG). Previous studies of the EEG in individuals with Rett syndrome have focused on morphological characteristics, but few have explored spectral power, including power as an index of brain function or disease severity. This study sought to determine if EEG power differs in girls with Rett syndrome and typically developing girls and among girls with Rett syndrome based on various clinical
Low (Sharma and Mohanan, 1980; Chacko et al., 2002). Pink disease caused by Corticium salmonicolor; stem canker caused by Cytospora eucalypticola and C. eucalypti (Sharma et al., 1990) and Cryphonectria canker disease. Outbreaks are localised up to 30% of the trees in a stand. Infection usually occurs on the main stem 1-1.5 m above ground and occasionally near ground level (Sharma et al., 1985). Web blight is caused by Rhizoctonia solani, damping-off by Pythium myriotylum and P. deliense, seedling blight by Cylindrocladium camelliae, leaf and shoot blights by C. clavatum and seedling wilt and root rot by Sclerotium rolfsii (Sharma et al., 1984; Mohanan and Sharma, 1985 ...
Background: Research indicates that some children with autism spectrum disorder (ASD) experience a developmental regression. Aims: The study examined the percentage of children with autism, pervasive developmental disorder (PDD), ASD, and Asperger syndrome (AS) who were considered to be delayed (D), regressed (R), or delayed and later regressed (DR) and examined any relationship with autism severity, time of onset, factors associated with onset, gastrointestinal (GI) symptoms, race, age, and gender. Materials and Methods: The study reviewed developmental and medical information based on parental reports of 135 children with a diagnosis of autism, PDD, ASD, or AS. Results: The number of children in the D group was 53 (39.2%) with 19 (14.1%) in the DR group and 63 (46.7%) in the R group. Thus, 82 children (60.7%) were reported to have R. In regard to onset of symptoms, there was a significant difference between the D and R groups as well as between the DR and R groups. The analyses showed that ...
The symptoms of Leigh syndrome are classically described as beginning in infancy and leading to death within a span of several years;[1] however, as more cases are recognized, it is apparent that symptoms can emerge at any age-including adolescence or adulthood-and patients can survive for many years following diagnosis.[5] Symptoms are often first seen after a triggering event that taxes the bodys energy production, such as an infection or surgery. The general course of Leigh syndrome is one of episodic developmental regression during times of metabolic stress. Some patients have long periods without disease progression while others develop progressive decline.[6] Infants with the syndrome have symptoms that include diarrhea, vomiting, and dysphagia (trouble swallowing or sucking), leading to a failure to thrive.[1] Children with early Leigh disease also may appear irritable and cry much more than usual. Seizures are often seen. Excess lactate may be seen in the urine, cerebrospinal fluid, and ...
Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of the children experience a developmental regression characterized by a loss of previously acquired skills and abilities. Typically reported are losses of verbal, nonverbal, and social abilities. Several recent studies suggest that children diagnosed with an ASD have abnormal sulfation chemistry, limited thiol availability, and decreased glutathione (GSH) reserve capacity, resulting in a compromised oxidation/reduction (redox) and detoxification capacity. Research indicates that the availability of thiols, particularly GSH, can influence the effects of thimerosal (TM) and other mercury (Hg) compounds. TM is an organomercurial compound (49.55% Hg by weight) that has been, and continues to be, used as a preservative in many childhood vaccines, particularly in developing countries. Thiol-modulating mechanisms affecting the cytotoxicity of TM have been identified. Importantly, the emergence of ASD symptoms post-6 months
Monies et al. (2017) reported the findings of 1000 diagnostic panels and exomes carried out at a next generation sequencing lab in Saudi Arabia. One patient, a 1-year-old female from a consanguineous family, presented with microcephaly, fine/gross motor delay, speech delay, learning disability, developmental regression, periventricular leukomalacia, prematurity, oligohydramnios, nystagmus and recurrent fever. Whole exome sequencing helped identify a homozygous mutation (c.70G,T, p.E24X) in exon 3 of the patients SIRT2 gene. This gene mutation was considered a candidate for pathogenicity as it was a novel variant located within the autozygome and was predicted to be deleterious; and the gene had been implicated in myelination. The authors noted the need for independent confirmation of this association. ...
Monies et al. (2017) reported the findings of 1000 diagnostic panels and exomes carried out at a next generation sequencing lab in Saudi Arabia. One patient, a 1-year-old female from a consanguineous family, presented with microcephaly, fine/gross motor delay, speech delay, learning disability, developmental regression, periventricular leukomalacia, prematurity, oligohydramnios, nystagmus and recurrent fever. Whole exome sequencing helped identify a homozygous mutation (c.70G,T, p.E24X) in exon 3 of the patients SIRT2 gene. This gene mutation was considered a candidate for pathogenicity as it was a novel variant located within the autozygome and was predicted to be deleterious; and the gene had been implicated in myelination. The authors noted the need for independent confirmation of this association. ...
At least 30 mutations in the MFSD8 gene have been found to cause CLN7 disease. This condition typically starts in early childhood with the loss of previously acquired skills (developmental regression), recurrent seizures (epilepsy), muscle twitches (myoclonus), difficulty coordinating movements (ataxia), speech impairment, and vision loss. Mental functioning and motor skills (such as sitting and walking) decline with age. Individuals with CLN7 disease typically do not survive past their teens.. MFSD8 gene mutations that cause CLN7 disease likely lead to the production of a protein with altered structure or function. One MFSD8 gene mutation is responsible for almost all cases of CLN7 disease in the Roma population of the Czech Republic. This mutation replaces the protein building block (amino acid) threonine with the amino acid lysine at position 294 in the MFSD8 protein (written as T294K). A variety of other mutations cause the condition in other populations.. It is unclear how an altered MFSD8 ...
In the 1940s, thimerosal was used in teething powders for infants and resulted in fatal outbreaks of Pinks Disease (severe mercury poisoning) before being removed in the 50s. Since many children today receive vaccines with trace amounts of thimerosal, in addition to vaccines containing adjuvant aluminum compounds, an important 1972 study published in the British Medical Journal noted that mercury increases aluminums oxidation and produces abnormal heat. In recent years, there is growing evidence of mitochondrial oxidation and cellular damage that may be due to this interaction between mercury and aluminum in vaccines. With a child now receiving 31 and more vaccinations during its first 18 months of life, it would seem that this barbaric practice would have been fully investigated by our health officials to account for the epidemic rise in neurological and behavioral disorders, adult diabetes and asthmatic conditions in American children. Instead, our health officials continue to pump out ...
Epileptic spasms, also known as infantile spasms, juvenile spasms, or West syndrome is an uncommon-to-rare epileptic disorder in infants, children and adults. It is named after the English physician, William James West (1793-1848), who first described it in an article published in The Lancet in 1841. The original case actually described his own son, James Edwin West (1840-1860). Other names for it are "generalized flexion epilepsy", "infantile epileptic encephalopathy", "infantile myoclonic encephalopathy", "jackknife convulsions", "massive myoclonia" and "Salaam spasms". The term "infantile spasms" can be used to describe the specific seizure manifestation in the syndrome, but is also used as a synonym for the syndrome itself. West syndrome in modern usage is the triad of infantile spasms, a pathognomonic EEG pattern (called hypsarrhythmia), and developmental regression - although the international definition requires only two out of these three elements. The syndrome is age-related, generally ...
To the Editor: We report on another child with subacute sclerosing panencephalitis (SSPE), expanding the case series reported by Kija et al. to six affected children from the Western Cape region of South Africa (SA) diagnosed in the past 18 months. The child presented to Red Cross War Memorial Children's Hospital, Cape Town, at 6 years and 3 months of age. She had recently returned to SA after living for several years in Zimbabwe. Her caregivers in SA had not seen her regularly, but understood that her previous health and development had been normal. She was admitted with a reported 1-day history of sudden onset weakness and abnormal movements. She had no known history of toxin exposure or prodromal symptoms prior to her presentation. She had neuro developmental regression and demonstrated emotional lability with incoherent speech and disorientation. She was not independently mobile.Her tone and power were normal and symmetrical with brisk deep tendon reflexes. Her abnormal movements were noted to
Acetobacter aceti has yet to be reported as a pathogenic microbe to humans or animals. Acetobacter aceti does not produce any toxins, enzymes, or any viruses that harm any human or animal. Since Acetobacter aceti is ubiquitous in nature and there is contact of this bacterium on all animals on a frequent basis. Acetobacter aceti is not a portion of normal flora of bacteria on human skin. The only potential pathology it could present is if presented in mass quantities, an allergic or immune response could occur. Acetobacter aceti does produce alcohols, meaning if consumed in large quantities, these alcohols could affect the central nervous system, causing intoxication via alcohol, a byproduct of Acetobacter aceti, although alcoholism or intoxication is not due to the bacterium. Acetobacter aceti is known to cause rotting and browning discoloration in fruits such as apples, pears, and citrus products. Acetobacter aceti is known for causing pink disease in pineapple, which is the turning of the ...
This case of acrodynia was traced to exposure of mercury from a carton of 8-foot fluorescent light bulbs that had broken in a ... Acrodynia is difficult to diagnose, "it is most often postulated that the etiology of this syndrome is an idiosyncratic ... Infantile acrodynia (also known as "calomel disease", "erythredemic polyneuropathy", and "pink disease") is a type of mercury ... Acrodynia resulted primarily from calomel in teething powders and decreased greatly after calomel was excluded from most ...
Infantile acrodynia[uredi , uredi kodo]. Bolezen je znana tudi pod imenom kalomelna bolezen, erythredemična polinevropatija in ... Acrodynia je bila razmeroma pogosta med otroci v prvi polovici 20. stoletja. Na začetku vzrok za epidemijo acrodynije pri ... Tunnessen WW Jr, McMahon KJ, Baser M (1987). "Acrodynia: exposure to mercury from fluorescent light bulbs". Pediatrics 79 (5): ... Iz leta 1987 izhaja poročilo o 23-mesečnem otroku, ki se je zastrupil z živim srebrom (infantile acrodynia) in utrpel posledice ...
Exposure to mercury, including infantile acrodynia. *Excessive dietary magnesium, as with supplementation.[citation needed] ...
A clinician should immediately consider acrodynia in an afebrile child who is sweating profusely.[citation needed] Some people ... Infantile acrodynia (childhood mercury poisoning) is characterized by excessive perspiration. ...
Mercury poisoning can result in several diseases, including acrodynia (pink disease), Hunter-Russell syndrome, and Minamata ...
Warkany and Hubbard (1953) noted in their seminal paper establishing mercury as the cause of infantile acrodynia that "... in ... in addition to the sharp decline in infantile acrodynia cases after the late 1950s following the removal of many sources of ...
Exposure to mercury, including infantile acrodynia. *Decreased magnesium.[9]. *Excessive dietary zinc, as with supplementation ...
It was removed from most powders in 1954 when it was shown to cause "pink disease" (acrodynia), a form of mercury poisoning. ...
... dermatitis acrodynia). He named this substance vitamin B6. In 1938, Samuel Lepkovsky isolated vitamin B6 from rice bran. Harris ...
Infantile acrodynia (childhood mercury poisoning) is characterized by excessive perspiration. A clinician should immediately ... consider acrodynia in an afebrile child who is sweating profusely. Some people can develop a sweat allergy.[17][18] The allergy ...
... including infantile acrodynia Excessive dietary magnesium, as with supplementation.[citation needed] Excessive dietary zinc, as ...
... kidney disease Neurobehavioral impairment Minamata disease Cerebellar ataxia Kidney and autoimmune dysfunction Acrodynia ...
... acrodynia), Crohn's disease, untreated/severe type 1 diabetes mellitus, anorexia nervosa, and hormonal deficiency.[medical ...
... acrodynia MeSH C10.886.425.175 --- sleep deprivation MeSH C10.886.425.200 --- sleep disorders, circadian rhythm MeSH C10.886. ... acrodynia MeSH C10.668.829.050 --- amyloid neuropathies MeSH C10.668.829.050.050 --- amyloid neuropathies, familial MeSH ...
Infections Encephalitis Guillain-Barré syndrome Infant botulism Meningitis Poliomyelitis Sepsis Toxins Infantile acrodynia ( ...
... infantile acrodynia).[citation needed] Classically, five days of fever plus four of five diagnostic criteria must be met to ...
... disease Fibromyalgia Congestive heart failure Anxiety Menopausal state Night sweats Compensatory Infantile acrodynia induced by ...
Acrodynia (calomel disease, erythredemic polyneuropathy, pink disease) Acute generalized exanthematous pustulosis (pustular ...
... acrodynia MeSH C21.613.680.262 --- ergotism MeSH C21.613.680.551 --- mushroom poisoning MeSH C21.613.705.100 --- akathisia, ...
The word acrodynia is derived from the Greek, where ακρος means end or extremity and οδυνη means pain. As such, it might be ( ... However, acrodynia is a disease rather than a symptom. The condition is known by a large number of other names including pink ... Acrodynia is a condition of pain and dusky pink discoloration in the hands and feet most often seen in children chronically ... Horowitz Y, Greenberg D, Ling G, Lifshitz M (2002). "Acrodynia: a case report of two siblings". Arch Dis Child. 86 (6): 453. ...
Hy neamde de faktor "rat acrodynia factor" of adermine. Yn 1938 slaggen fiif ferskillende groepen wittenskippers, wêrûnder ... dermititis acrodynia) tefoaren komme koe. De Hongaarske mikrobiolooch en biogemikus Paul György beskreau yn 1934 as earste ...
Research has identified health-behavioral and biological factors that are related to increased risk for CVD. These risk factors include smoking, obesity, low density lipoprotein (the "bad" cholesterol), lack of exercise, and blood pressure. Psychosocial working conditions are also risk factors for CVD.[1] In a case-control study involving two large U.S. data sets, Murphy (1991) found that hazardous work situations, jobs that required vigilance and responsibility for others, and work that required attention to devices were related to increased risk for cardiovascular disability.[66] These included jobs in transportation (e.g., air traffic controllers, airline pilots, bus drivers, locomotive engineers, truck drivers), preschool teachers, and craftsmen. Among 30 studies involving men[67] and women,[68] most have found an association between workplace stressors and CVD. Fredikson, Sundin, and Frankenhaeuser (1985) found that reactions to psychological stressors include increased activity in the ...
For medical devices, risk management is a process for identifying, evaluating and mitigating risks associated with harm to people and damage to property or the environment. Risk management is an integral part of medical device design and development, production processes and evaluation of field experience, and is applicable to all types of medical devices. The evidence of its application is required by most regulatory bodies such as the US FDA. The management of risks for medical devices is described by the International Organization for Standardization (ISO) in ISO 14971:2007, Medical Devices-The application of risk management to medical devices, a product safety standard. The standard provides a process framework and associated requirements for management responsibilities, risk analysis and evaluation, risk controls and lifecycle risk management. The European version of the risk management standard was updated in 2009 and again in 2012 to refer to the Medical Devices Directive (MDD) and Active ...
The death of English textile worker Nellie Kershaw in 1924 from pulmonary asbestosis was the first case to be described in medical literature, and the first published account of disease attributed to occupational asbestos exposure. However, her former employers (Turner Brothers Asbestos) denied that asbestosis even existed because the medical condition was not officially recognised at the time. As a result, they accepted no liability for her injuries and paid no compensation, either to Kershaw during her final illness or to her bereaved family after she had died. Even so, the findings of the inquest into her death were highly influential insofar as they led to a parliamentary enquiry by the British Parliament. The enquiry formally acknowledged the existence of asbestosis, recognised that it was hazardous to health and concluded that it was irrefutably linked to the prolonged inhalation of asbestos dust. Having established the existence of asbestosis on a medical and judicial basis, the report ...
There are no quick fixes for RSI. Early diagnosis is critical to limiting damage.[16] RICE is used as the first treatment for many muscle strains, ligament sprains, or other bruises and injuries. RICE stands for Rest, Ice, Compression, and Elevation. RICE is used immediately after an injury happens and for the first 24 to 48 hours after the injury. These modalities can help reduce the swelling and pain.[17] Commonly prescribed treatments for early-stage RSIs include analgesics, myofeedback, biofeedback, physical therapy, relaxation, and ultrasound therapy.[6] Low-grade RSIs can sometimes resolve themselves if treatments begin shortly after the onset of symptoms. However, some RSIs may require more aggressive intervention including surgery and can persist for years. Although there are no "quick fixes" for RSI, there are effective approaches to its treatment and prevention.[18] One is that of ergonomics, the changing of one's environment (especially workplace equipment) to minimize repetitive ...
Acrodynia is characterized by pink discoloration of the hands and feet, irritability, photophobia (sensitivity to light) and ... Retrieved from "https://www.wikidoc.org/index.php?title=Acrodynia&oldid=667667" ...
The word acrodynia is derived from the Greek, where ακρος means end or extremity and οδυνη means pain. As such, it might be ( ... However, acrodynia is a disease rather than a symptom. The condition is known by a large number of other names including pink ... Acrodynia is a condition of pain and dusky pink discoloration in the hands and feet most often seen in children chronically ... Horowitz Y, Greenberg D, Ling G, Lifshitz M (2002). "Acrodynia: a case report of two siblings". Arch Dis Child. 86 (6): 453. ...
"Acrodynia" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Acrodynia" by people in Harvard Catalyst Profiles by year, and ... Below are the most recent publications written about "Acrodynia" by people in Profiles. ... whether "Acrodynia" was a major or minor topic of these publication. ...
Mercury in House Paint as a Cause of Acrodynia: Effect of Therapy with N-Acetyl-D, L-Penixillamine: People are increasingly co ... Case Study 21: Mercury in House Paint as a Cause of Acrodynia: Effect of Therapy with N-Acetyl-D, L-Penixillamine 445-449 ... A case of acrodynia in a patient who had increased urinary excretion of mercury is presented. New methods for mercury analysis ... Whether acrodynia represents an allergic reaction to mercury, as originally suggested by Helmick,24 or is merely an expression ...
The first recognized account of the disease was in 1828 and until the term acrodynia was introduced it was known as the malady ... The term acrodynia (ακρος an extremity, όδύνη pain) was coined about 1830 in France to meet the need of a word to designate a ... The term acrodynia (ακρος an extremity, όδύνη pain) was coined about 1830 in France to meet the need of a word to designate a ... Acrodynia: Its Place in Medicine and its Relation to Pellagra * Edward J. Wood ...
Muscle pain; headache; acrodynia; colic. Arsenic, Copper, Lead, Thallium. Alopecia (hair loss) ...
Acrodynia epidemic. Acrodynia is a type of mercury poisoning in children characterized by pain and pink discoloration of the ... a b c Horowitz Y, Greenberg D, Ling G, Lifshitz M. Acrodynia: a case report of two siblings. Arch Dis Child 2002; 86: 453. PMID ... Mercury poisoning (also known as mercurialism, hydrargyria, Hunter-Russell syndrome, or acrodynia when affecting children) is a ... However, acrodynia is a disease rather than a symptom.[2] Also known as pink disease, erythredema, Selters disease, or Swift- ...
Infantile acrodynia[uredi , uredi kodo]. Bolezen je znana tudi pod imenom kalomelna bolezen, erythredemična polinevropatija in ... Acrodynia je bila razmeroma pogosta med otroci v prvi polovici 20. stoletja. Na začetku vzrok za epidemijo acrodynije pri ... Tunnessen WW Jr, McMahon KJ, Baser M (1987). "Acrodynia: exposure to mercury from fluorescent light bulbs". Pediatrics 79 (5): ... Iz leta 1987 izhaja poročilo o 23-mesečnem otroku, ki se je zastrupil z živim srebrom (infantile acrodynia) in utrpel posledice ...
Acrodynia and mercury. J Pediatr. 1953. 42:365-386. *. Yoshida Y, Kamitsuchibashi H, Hamada R, et al. Truncal hypesthesia in ...
Cheek D. Acrodynia. In: Kelley V, ed. Brennemans Practice of Pediatrics. New York, NY: Harper & Row Publishers; 1977:1-12 ... Sporadic cases of acrodynia have resulted from children playing on carpet contaminated by metallic mercury. Once a carpet is ... Acrodynia (painful extremities), also known as pink disease, seems to be a hypersensitivity response to mercury and was ... 1963) Mercury in house paint as a cause of acrodynia. N Engl J Med 269:889-893. ...
Exposure to mercury, including infantile acrodynia. *Excessive dietary magnesium, as with supplementation.[citation needed] ...
Acrodynia may be misdiagnosed as measles, other viral exanthems, or Kawasaki disease. Manifestations of acrodynia include a ... acrodynia was diagnosed. On December 1, the patients 11-year-old sister was hospitalized with hypertension, mild acrodynia, ... On November 22, 1989, a 15-year-old male who had been hospitalized in Columbus, Ohio, was diagnosed with acrodynia, a form of ... 9. Alexander JF, Rosario R. A case of mercury poisoning: acrodynia in a child of 8. Can Med Assoc J 1971;104:929-30. 10. ...
Acrodynia. Personality change. Neurological dysfunction. Health Problems Related to Environmental Tobacco Smoke. Key Signs ...
Acrodynia is typically caused by inorganic mercury poisoning; however, as demonstrated in our work, new cases are being ... Our 2 patients and the 6 additional patients found in the search of Medline have acrodynia. These children, from 11 months to ... Warkany and Hubbard,8 in their series of 28 pediatric patients published in 1953, established the link between acrodynia ( ... 1993) Acute mercury poisoning (acrodynia) mimicking pheochromocytoma in an adolescent. J Pediatr 122:252-253. ...
Acrodynia and mercury. J. Pediatr. 42: 365-386.. Waste-Tech (Waste Energy Technologies). 1991. The New York City Medical Waste ...
Acrodynia - low sodium levels. What Are the Causes of Low Sodium Levels in Blood ... ...
Acrodynia resulting from fluorescent bulbs has not been previously reported.). Dinehart, SM, Dillard, R, Raimer, SS, Diven, S, ... A diagnosis of acrodynia, or pink disease, was confirmed by elevated levels of mercury in the urine. The many cutaneous ... Acrodynia, or pink disease, is childhood mercury poisoning as a result of prolonged exposure to mercury. Inhalation of ... The report summarizes the case of a 14-year-old boy who developed acrodynia during the first year of life from topical ...
2. Acrodynia. 3. Addisons Disease. 4. Adrenal Cortex Diseases. 5. Ascites. 6. Bamforth syndrome. 7. Bartter Syndrome type 4. 8 ...
7. Acrodynia. 8. Acromegaloid, Cutis Verticis Gyrata, Corneal Leukoma Syndrome. 9. Acute fatty liver of pregnancy. 10. ...
4. Acrodynia. 5. Actinomycetales infection. 6. Acute adult T-Cell leukemia. 7. Acute bacterial prostatitis. 8. Acute ...
6. Acrodynia. 7. Actinic keratosis. 8. Adrenal hemorrhage, neonatal. 9. Adverse reaction to chemical -- 1,2-Dibromoethane. 10. ...
3. Acrodynia. 4. Acute Pesticide poisoning -- xylene. 5. Adhesive abuse. 6. Adhesive addiction. 7. Aerosol abuse. 8. Aerosol ...
3. Acrodynia. 4. Acroparesthesia syndrome. 5. Acute Bokhoror. 6. Acute bacterial prostatitis. 7. Acute intermittent porphyria. ...
7. Acrodynia. 8. Acute bacterial prostatitis. 9. Acute intermittent porphyria. 10. Acute mountain sickness. More causes » , ...
6. Acrodynia. 7. Acromegaloid, Cutis Verticis Gyrata, Corneal Leukoma Syndrome. 8. Acute Bokhoror. 9. Acute Chemical poisoning ...
  • Another prevailing, sometimes fatal, disease that affected children through the late 1940s was called acrodynia (or pink disease), meaning "pain in the hands and feet. (westonaprice.org)
  • On December 1, the patient's 11-year-old sister was hospitalized with hypertension, mild acrodynia, irritability, and mild generalized muscle weakness. (cdc.gov)
  • After both patients were diagnosed as having acrodynia with neuropsychiatric impairment, they were treated with oral 2,3-dimercaptosuccinic acid (DMSA). (cdc.gov)
  • The word acrodynia is derived from the Greek, where ακρος means end or extremity and οδυνη means pain. (wikipedia.org)
  • The term acrodynia (ακρος an extremity, όδύνη pain) was coined about 1830 in France to meet the need of a word to designate a condition regarded as altogether new and hitherto undescribed under any other single designation. (ajtmh.org)