Dissolution of bone that particularly involves the removal or loss of calcium.
Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.
A vinyl polymer made from ethylene. It can be branched or linear. Branched or low-density polyethylene is tough and pliable but not to the same degree as linear polyethylene. Linear or high-density polyethylene has a greater hardness and tensile strength. Polyethylene is used in a variety of products, including implants and prostheses.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
Replacement for a hip joint.
Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.
Replacement of the hip joint.
The plan and delineation of prostheses in general or a specific prosthesis.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Bone loss due to osteoclastic activity.
Rare, autosomal dominant syndrome characterized by ACRO-OSTEOLYSIS, generalized OSTEOPOROSIS, and skull deformations.
The part of the pelvis that comprises the pelvic socket where the head of FEMUR joins to form HIP JOINT (acetabulofemoral joint).
An oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Tumors or cancer located in bone tissue or specific BONES.
The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
Polymerized methyl methacrylate monomers which are used as sheets, moulding, extrusion powders, surface coating resins, emulsion polymers, fibers, inks, and films (From International Labor Organization, 1983). This material is also used in tooth implants, bone cements, and hard corneal contact lenses.
The joining of objects by means of a cement (e.g., in fracture fixation, such as in hip arthroplasty for joining of the acetabular component to the femoral component). In dentistry, it is used for the process of attaching parts of a tooth or restorative material to a natural tooth or for the attaching of orthodontic bands to teeth by means of an adhesive.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Partial or total replacement of a joint.
Replacement for a knee joint.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
Prostheses used to partially or totally replace a human or animal joint. (from UMDNS, 1999)
Inflammation of the bone.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
The prevention of access by infecting organisms to the locus of potential infection.
Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.
The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)
A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
General or unspecified injuries involving the hip.
Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.
The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
A condition with multiple tumor-like lesions caused either by congenital or developmental malformations of BLOOD VESSELS, or reactive vascular proliferations, such as in bacillary angiomatosis. Angiomatosis is considered non-neoplastic.
Chronic inflammation and granuloma formation around irritating foreign bodies.
Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and LEGG-CALVE-PERTHES DISEASE.
Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.
Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)
Death of a bone or part of a bone, either atraumatic or posttraumatic.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
The presence of chyle in the thoracic cavity. (Dorland, 27th ed)
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Replacement of the knee joint.
A bone on the ventral side of the shoulder girdle, which in humans is commonly called the collar bone.
Deformities of the hand, or a part of the hand, acquired after birth as the result of injury or disease.
The gradual destruction of a metal or alloy due to oxidation or action of a chemical agent. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. (1/10)

Mandibuloacral dysplasia (MAD; OMIM 248370) is a rare, genetically and phenotypically heterogeneous, autosomal recessive disorder characterized by skeletal abnormalities including hypoplasia of the mandible and clavicles, acro-osteolysis, cutaneous atrophy and lipodystrophy. A homozygous missense mutation, Arg527His, in the LMNA gene which encodes nuclear lamina proteins lamins A and C has been reported in patients with MAD and partial lipodystrophy. We studied four patients with MAD who had no mutations in the LMNA gene. We now show compound heterozygous mutations, Phe361fsX379 and Trp340Arg, in the zinc metalloproteinase (ZMPSTE24) gene in one of the four patients who had severe MAD associated with progeroid appearance and generalized lipodystrophy. ZMPSTE24 is involved in post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A in two steps to form mature lamin A. Deficiency of Zmpste24 in mice causes accumulation of prelamin A and phenotypic features similar to MAD. The yeast homolog, Ste24, has a parallel role in processing of prenylated mating pheromone a-factor. Since human ZMPSTE24 can also process a-factor when expressed in yeast, we assessed the functional significance of the two ZMPSTE24 mutations in the yeast to complement the mating defect of the haploid MATa yeast lacking STE24 and Ras-converting enzyme 1 (RCE1; another prenylprotein-specific endoprotease) genes. The ZMPSTE24 mutant construct, Phe361fsX379, was inactive in complementing the yeast a-factor but the mutant, Trp340Arg, was partially active compared to the wild type ZMPSTE24 construct. We conclude that mutations in ZMPSTE24 may cause MAD by affecting prelamin A processing.  (+info)

Faun tail naevus: a cutaneous marker of spinal dysraphism. (2/10)

We describe three cases (one male and two females) of faun tail nevi, which is one of the most important cutaneous marker of spinal dysraphism. One of the patients presented with acro-osteolysis leading to auto amputation of the toes of the left foot, which required operative intervention. This lays stress on the early recognition of lumbar paraspinal skin lesions and early treatment to avoid irreversible sequelae.  (+info)

Radiological bone lesions in fibroblastic rheumatism; case report. (3/10)

INTRODUCTION: Fibroblastic rheumatism (FR) is a rare disease characterized by polyarthralgia associated with painless subcutaneous nodules, sclerodactyly and finger contractures. CASE REPORT: A 45-year-old man presented with peripheral vascular disease, polyarthralgia and subcutaneous nodules. The diagnosis of FR was confirmed by histological examination of a biopsy sample of a nodule, which showed myofibroblast proliferation. Radiographs of both hands showed bilateral erosion of the distal and proximal interphalangeal joints, of the right trapezium bone and acro-osteolysis of the third phalanx of the right-hand second finger. COMMENTS: Although the clinical features of FR have now been well described, the literature includes few radiological descriptions. In most reported cases, radiographs are normal at disease onset. Joint radiographs performed later usually show bone destruction of the hands and feet.  (+info)

Acro-osteolysis and mononeuritis multiplex as a presenting symptom of systemic angiitis of Wegener's type. (4/10)

Wegener's granulomatosis is a multisystem disorder involving small- and medium-sized vessels, leading to granuloma formation and involvement of upper and lower respiratory tract with or without glomerulonephritis. However, limited forms of angiitis and granulomatosis of the Wegener's type with oligosymptomatic and atypical site involvement are known to occur. We present here a rare case of limited form of angiitis and granulomatosis of Wegener's type who presented sequentially with spontaneous resorption of digits with acro-osteolysis and mononeuritis multiplex over a period of 10 months. His vasculitic workup revealed high proteinase 3 antibodies (c-ANCA) titers and an almost asymptomatic lung involvement, detected on high-resolution computed tomography of chest. The patient was aggressively treated with immunosuppressive therapy, following which he showed good improvement.  (+info)

Type B mandibuloacral dysplasia with congenital myopathy due to homozygous ZMPSTE24 missense mutation. (5/10)


Osteoblasts from a mandibuloacral dysplasia patient induce human blood precursors to differentiate into active osteoclasts. (6/10)


Effect of zoledronic acid on acro-osteolysis and osteoporosis in a patient with Hajdu-Cheney syndrome. (7/10)


Salim Haim and the syndrome that bears his name. (8/10)

Professor Salim Haim (1919-1983) was a well-known dermatologist. In 1965, Dr. Haim and Dr. Munk, a radiologist, reported a rare congenital type of genodermatosis, later known as Haim-Munk syndrome. This syndrome is characterized by palmoplantar keratosis, pes planus, onychogryphosis, periodontitis, arachnodactyly, and acroosteolysis. This report discusses Haim and Haim-Munk syndrome.  (+info)

Osteolysis is a medical term that refers to the loss or resorption of bone tissue. It's a process where the body's normal bone remodeling cycle is disrupted, leading to an imbalance between bone formation and bone breakdown. This results in the progressive deterioration and destruction of bone.

Osteolysis can occur due to various reasons such as chronic inflammation, mechanical stress, or certain medical conditions like rheumatoid arthritis, Paget's disease, or bone tumors. It can also be a side effect of some medications, such as those used in cancer treatment or for managing osteoporosis.

In severe cases, osteolysis can lead to weakened bones, increased risk of fractures, and deformities. Treatment typically aims to address the underlying cause and may include medication, surgery, or lifestyle changes.

Essential osteolysis is not a well-defined medical condition with a single, widely accepted medical definition. The term "osteolysis" generally refers to the loss or resorption of bone tissue. In essential osteolysis, this process occurs without an underlying cause that can be easily identified, such as a tumor, infection, or other disease.

Some sources describe essential osteolysis as a condition characterized by progressive bone loss that occurs spontaneously and symmetrically, typically affecting the small bones of the hands and feet. The exact cause of this form of osteolysis is not known, but it is thought to be related to an abnormal immune response or genetic factors.

It's important to note that essential osteolysis is a rare condition, and its symptoms and progression can vary significantly from person to person. If you have concerns about osteolysis or any other medical condition, it's best to consult with a healthcare professional for an accurate diagnosis and treatment plan.

I'm sorry for any confusion, but "Polyethylene" is not a medical term. It is a type of synthetic plastic that is commonly used in various industrial and consumer products. Medical definitions typically refer to substances or conditions related to human health, treatment, or disease processes. If you have any questions related to medical terminology or concepts, I'd be happy to help!

Prosthesis failure is a term used to describe a situation where a prosthetic device, such as an artificial joint or limb, has stopped functioning or failed to meet its intended purpose. This can be due to various reasons, including mechanical failure, infection, loosening of the device, or a reaction to the materials used in the prosthesis.

Mechanical failure can occur due to wear and tear, manufacturing defects, or improper use of the prosthetic device. Infection can also lead to prosthesis failure, particularly in cases where the prosthesis is implanted inside the body. The immune system may react to the presence of the foreign material, leading to inflammation and infection.

Loosening of the prosthesis can also cause it to fail over time, as the device becomes less stable and eventually stops working properly. Additionally, some people may have a reaction to the materials used in the prosthesis, leading to tissue damage or other complications that can result in prosthesis failure.

In general, prosthesis failure can lead to decreased mobility, pain, and the need for additional surgeries or treatments to correct the problem. It is important for individuals with prosthetic devices to follow their healthcare provider's instructions carefully to minimize the risk of prosthesis failure and ensure that the device continues to function properly over time.

A hip prosthesis, also known as a total hip replacement, is a surgical implant designed to replace the damaged or diseased components of the human hip joint. The procedure involves replacing the femoral head (the ball at the top of the thigh bone) and the acetabulum (the socket in the pelvis) with artificial parts, typically made from materials such as metal, ceramic, or plastic.

The goal of a hip prosthesis is to relieve pain, improve joint mobility, and restore function, allowing patients to return to their normal activities and enjoy an improved quality of life. The procedure is most commonly performed in individuals with advanced osteoarthritis, rheumatoid arthritis, or other degenerative conditions that have caused significant damage to the hip joint.

There are several different types of hip prostheses available, each with its own unique design and set of benefits and risks. The choice of prosthesis will depend on a variety of factors, including the patient's age, activity level, overall health, and specific medical needs. In general, however, all hip prostheses are designed to provide a durable, long-lasting solution for patients suffering from debilitating joint pain and stiffness.

I believe there may be some confusion in your question as Polyethylenes are not a medical term, but rather a category of synthetic polymers commonly used in various industrial and medical applications. Here's a brief overview:

Polyethylene (PE) is a type of thermoplastic polymer made from the monomer ethylene. It is a versatile material with numerous applications due to its chemical resistance, durability, and flexibility. There are several types of polyethylenes, including:

1. Low-density polyethylene (LDPE): This type has a lower density and more branching in its molecular structure, which results in less crystallinity. LDPE is known for its flexibility and is often used in packaging films, bags, and containers.
2. High-density polyethylene (HDPE): HDPE has a higher density and less branching, resulting in greater crystallinity. It is more rigid than LDPE and is commonly used in applications such as bottles, pipes, and containers.
3. Linear low-density polyethylene (LLDPE): This type combines the flexibility of LDPE with some of the strength and rigidity of HDPE. LLDPE has fewer branches than LDPE but more than HDPE. It is often used in film applications, such as stretch wrap and agricultural films.
4. Ultra-high molecular weight polyethylene (UHMWPE): UHMWPE has an extremely high molecular weight, resulting in exceptional wear resistance, impact strength, and chemical resistance. It is commonly used in medical applications, such as orthopedic implants and joint replacements, due to its biocompatibility and low friction coefficient.

While polyethylenes are not a medical term per se, they do have significant medical applications, particularly UHMWPE in orthopedic devices.

Hip arthroplasty, also known as hip replacement surgery, is a medical procedure where the damaged or diseased joint surfaces of the hip are removed and replaced with artificial components. These components typically include a metal or ceramic ball that replaces the head of the femur (thigh bone), and a polyethylene or ceramic socket that replaces the acetabulum (hip socket) in the pelvis.

The goal of hip arthroplasty is to relieve pain, improve joint mobility, and restore function to the hip joint. This procedure is commonly performed in patients with advanced osteoarthritis, rheumatoid arthritis, hip fractures, or other conditions that cause significant damage to the hip joint.

There are several types of hip replacement surgeries, including traditional total hip arthroplasty, partial (hemi) hip arthroplasty, and resurfacing hip arthroplasty. The choice of procedure depends on various factors, such as the patient's age, activity level, overall health, and the extent of joint damage.

After surgery, patients typically require rehabilitation to regain strength, mobility, and function in the affected hip. With proper care and follow-up, most patients can expect significant pain relief and improved quality of life following hip arthroplasty.

Prosthesis design is a specialized field in medical device technology that involves creating and developing artificial substitutes to replace a missing body part, such as a limb, tooth, eye, or internal organ. The design process typically includes several stages: assessment of the patient's needs, selection of appropriate materials, creation of a prototype, testing and refinement, and final fabrication and fitting of the prosthesis.

The goal of prosthesis design is to create a device that functions as closely as possible to the natural body part it replaces, while also being comfortable, durable, and aesthetically pleasing for the patient. The design process may involve collaboration between medical professionals, engineers, and designers, and may take into account factors such as the patient's age, lifestyle, occupation, and overall health.

Prosthesis design can be highly complex, particularly for advanced devices such as robotic limbs or implantable organs. These devices often require sophisticated sensors, actuators, and control systems to mimic the natural functions of the body part they replace. As a result, prosthesis design is an active area of research and development in the medical field, with ongoing efforts to improve the functionality, comfort, and affordability of these devices for patients.

Osteoclasts are large, multinucleated cells that are primarily responsible for bone resorption, a process in which they break down and dissolve the mineralized matrix of bones. They are derived from monocyte-macrophage precursor cells of hematopoietic origin and play a crucial role in maintaining bone homeostasis by balancing bone formation and bone resorption.

Osteoclasts adhere to the bone surface and create an isolated microenvironment, called the "resorption lacuna," between their cell membrane and the bone surface. Here, they release hydrogen ions into the lacuna through a process called proton pumping, which lowers the pH and dissolves the mineral component of the bone matrix. Additionally, osteoclasts secrete proteolytic enzymes, such as cathepsin K, that degrade the organic components, like collagen, in the bone matrix.

An imbalance in osteoclast activity can lead to various bone diseases, including osteoporosis and Paget's disease, where excessive bone resorption results in weakened and fragile bones.

Bone resorption is the process by which bone tissue is broken down and absorbed into the body. It is a normal part of bone remodeling, in which old or damaged bone tissue is removed and new tissue is formed. However, excessive bone resorption can lead to conditions such as osteoporosis, in which bones become weak and fragile due to a loss of density. This process is carried out by cells called osteoclasts, which break down the bone tissue and release minerals such as calcium into the bloodstream.

Hajdu-Cheney Syndrome (HCS) is a rare genetic disorder characterized by skeletal abnormalities, distinctive facial features, and potential complications involving other organ systems. The syndrome is caused by mutations in the NOTCH2 gene, which plays a crucial role in bone development and maintenance.

The main features of Hajdu-Cheney Syndrome include:

1. Acroosteolysis: Progressive destruction and resorption of the distal phalanges (the bones at the ends of fingers and toes) leading to shortened, deformed fingers and toes.
2. Osteoporosis: Generalized bone loss resulting in increased fracture risk and bone deformities.
3. Widened cranial sutures: The fibrous joints between the bones in the skull remain open longer than usual, leading to a wide appearance of the forehead and other facial features.
4. Facial abnormalities: Include a prominent forehead (frontal bossing), widely spaced eyes (hypertelorism), down-slanting palpebral fissures (the openings for the eyes), a flat nasal bridge, and a pointed chin.
5. Dental anomalies: Including widely spaced teeth, irregular tooth enamel, and an increased risk of periodontal disease.
6. Neurological issues: Some individuals with HCS may experience hearing loss, cognitive impairment, or cerebrovascular complications (such as strokes).
7. Cardiovascular abnormalities: Including mitral valve prolapse and aortic root dilation.
8. Increased cancer risk: There is an increased incidence of various types of cancers in individuals with HCS, particularly gastrointestinal malignancies.

Due to the rarity of this condition, its diagnosis often requires genetic testing for mutations in the NOTCH2 gene and a multidisciplinary approach to management, involving specialists such as clinical geneticists, orthopedic surgeons, neurologists, dentists, and other healthcare professionals.

The acetabulum is the cup-shaped cavity in the pelvic bone (specifically, the os coxa) where the head of the femur bone articulates to form the hip joint. It provides a stable and flexible connection between the lower limb and the trunk, allowing for a wide range of movements such as flexion, extension, abduction, adduction, rotation, and circumduction. The acetabulum is lined with articular cartilage, which facilitates smooth and frictionless movement of the hip joint. Its stability is further enhanced by various ligaments, muscles, and the labrum, a fibrocartilaginous rim that deepens the socket and increases its contact area with the femoral head.

Aluminum oxide is a chemical compound with the formula Al2O3. It is also known as alumina and it is a white solid that is widely used in various industries due to its unique properties. Aluminum oxide is highly resistant to corrosion, has a high melting point, and is an electrical insulator.

In the medical field, aluminum oxide is used in a variety of applications such as:

1. Dental crowns and implants: Aluminum oxide is used in the production of dental crowns and implants due to its strength and durability.
2. Orthopedic implants: Aluminum oxide is used in some types of orthopedic implants, such as knee and hip replacements, because of its biocompatibility and resistance to wear.
3. Medical ceramics: Aluminum oxide is used in the production of medical ceramics, which are used in various medical devices such as pacemakers and hearing aids.
4. Pharmaceuticals: Aluminum oxide is used as an excipient in some pharmaceutical products, such as tablets and capsules, to improve their stability and shelf life.
5. Medical research: Aluminum oxide is used in medical research, for example, as a substrate material for growing cells or as a coating material for medical devices.

It's important to note that while aluminum oxide has many useful applications in the medical field, exposure to high levels of aluminum can be harmful to human health. Therefore, it is important to use aluminum oxide and other aluminum-containing materials safely and according to established guidelines.

A reoperation is a surgical procedure that is performed again on a patient who has already undergone a previous operation for the same or related condition. Reoperations may be required due to various reasons, such as inadequate initial treatment, disease recurrence, infection, or complications from the first surgery. The nature and complexity of a reoperation can vary widely depending on the specific circumstances, but it often carries higher risks and potential complications compared to the original operation.

Bone neoplasms are abnormal growths or tumors that develop in the bone. They can be benign (non-cancerous) or malignant (cancerous). Benign bone neoplasms do not spread to other parts of the body and are rarely a threat to life, although they may cause problems if they grow large enough to press on surrounding tissues or cause fractures. Malignant bone neoplasms, on the other hand, can invade and destroy nearby tissue and may spread (metastasize) to other parts of the body.

There are many different types of bone neoplasms, including:

1. Osteochondroma - a benign tumor that develops from cartilage and bone
2. Enchondroma - a benign tumor that forms in the cartilage that lines the inside of the bones
3. Chondrosarcoma - a malignant tumor that develops from cartilage
4. Osteosarcoma - a malignant tumor that develops from bone cells
5. Ewing sarcoma - a malignant tumor that develops in the bones or soft tissues around the bones
6. Giant cell tumor of bone - a benign or occasionally malignant tumor that develops from bone tissue
7. Fibrosarcoma - a malignant tumor that develops from fibrous tissue in the bone

The symptoms of bone neoplasms vary depending on the type, size, and location of the tumor. They may include pain, swelling, stiffness, fractures, or limited mobility. Treatment options depend on the type and stage of the tumor but may include surgery, radiation therapy, chemotherapy, or a combination of these treatments.

The hip joint, also known as the coxal joint, is a ball-and-socket type synovial joint that connects the femur (thigh bone) to the pelvis. The "ball" is the head of the femur, while the "socket" is the acetabulum, a concave surface on the pelvic bone.

The hip joint is surrounded by a strong fibrous capsule and is reinforced by several ligaments, including the iliofemoral, ischiofemoral, and pubofemoral ligaments. The joint allows for flexion, extension, abduction, adduction, medial and lateral rotation, and circumduction movements, making it one of the most mobile joints in the body.

The hip joint is also supported by various muscles, including the gluteus maximus, gluteus medius, gluteus minimus, iliopsoas, and other hip flexors and extensors. These muscles provide stability and strength to the joint, allowing for weight-bearing activities such as walking, running, and jumping.

REceptor Activator of NF-kB (RANK) Ligand is a type of protein that plays a crucial role in the immune system and bone metabolism. It belongs to the tumor necrosis factor (TNF) superfamily and is primarily produced by osteoblasts, which are cells responsible for bone formation.

RANK Ligand binds to its receptor RANK, which is found on the surface of osteoclasts, a type of cell involved in bone resorption or breakdown. The binding of RANK Ligand to RANK activates signaling pathways that promote the differentiation, activation, and survival of osteoclasts, thereby increasing bone resorption.

Abnormalities in the RANKL-RANK signaling pathway have been implicated in various bone diseases, such as osteoporosis, rheumatoid arthritis, and certain types of cancer that metastasize to bones. Therefore, targeting this pathway with therapeutic agents has emerged as a promising approach for the treatment of these conditions.

Titanium is not a medical term, but rather a chemical element (symbol Ti, atomic number 22) that is widely used in the medical field due to its unique properties. Medically, it is often referred to as a biocompatible material used in various medical applications such as:

1. Orthopedic implants: Titanium and its alloys are used for making joint replacements (hips, knees, shoulders), bone plates, screws, and rods due to their high strength-to-weight ratio, excellent corrosion resistance, and biocompatibility.
2. Dental implants: Titanium is also commonly used in dental applications like implants, crowns, and bridges because of its ability to osseointegrate, or fuse directly with bone tissue, providing a stable foundation for replacement teeth.
3. Cardiovascular devices: Titanium alloys are used in the construction of heart valves, pacemakers, and other cardiovascular implants due to their non-magnetic properties, which prevent interference with magnetic resonance imaging (MRI) scans.
4. Medical instruments: Due to its resistance to corrosion and high strength, titanium is used in the manufacturing of various medical instruments such as surgical tools, needles, and catheters.

In summary, Titanium is a chemical element with unique properties that make it an ideal material for various medical applications, including orthopedic and dental implants, cardiovascular devices, and medical instruments.

The skull is the bony structure that encloses and protects the brain, the eyes, and the ears. It is composed of two main parts: the cranium, which contains the brain, and the facial bones. The cranium is made up of several fused flat bones, while the facial bones include the upper jaw (maxilla), lower jaw (mandible), cheekbones, nose bones, and eye sockets (orbits).

The skull also provides attachment points for various muscles that control chewing, moving the head, and facial expressions. Additionally, it contains openings for blood vessels, nerves, and the spinal cord to pass through. The skull's primary function is to protect the delicate and vital structures within it from injury and trauma.

Polymethyl methacrylate (PMMA) is a type of synthetic resin that is widely used in the medical field due to its biocompatibility and versatility. It is a transparent, rigid, and lightweight material that can be easily molded into different shapes and forms. Here are some of the medical definitions of PMMA:

1. A biocompatible acrylic resin used in various medical applications such as bone cement, intraocular lenses, dental restorations, and drug delivery systems.
2. A type of synthetic material that is used as a bone cement to fix prosthetic joint replacements and vertebroplasty for the treatment of spinal fractures.
3. A transparent and shatter-resistant material used in the manufacture of medical devices such as intravenous (IV) fluid bags, dialyzer housings, and oxygenators.
4. A drug delivery system that can be used to administer drugs locally or systemically, such as intraocular sustained-release drug implants for the treatment of chronic eye diseases.
5. A component of dental restorations such as fillings, crowns, and bridges due to its excellent mechanical properties and esthetic qualities.

Overall, PMMA is a versatile and valuable material in the medical field, with numerous applications that take advantage of its unique properties.

In the medical field, cementation refers to the process of using a type of dental cement or bonding agent to attach a dental restoration (such as a crown, bridge, or false tooth) to a natural tooth or implant. The cement helps to create a strong and secure attachment, while also helping to seal the restoration and prevent the entry of bacteria and saliva.

Dental cement can be made from various materials, including glass ionomers, resin-modified glass ionomers, zinc phosphate, and polycarboxylate cements. The choice of cement depends on several factors, such as the type of restoration being attached, the location in the mouth, and the patient's individual needs and preferences.

Cementation is an important step in many dental procedures, as it helps to ensure the longevity and success of the restoration. Proper technique and material selection are crucial for achieving a successful cementation that will last for years to come.

Bone cements are medical-grade materials used in orthopedic and trauma surgery to fill gaps between bone surfaces and implants, such as artificial joints or screws. They serve to mechanically stabilize the implant and provide a smooth, load-bearing surface. The two most common types of bone cement are:

1. Polymethylmethacrylate (PMMA) cement: This is a two-component system consisting of powdered PMMA and liquid methyl methacrylate monomer. When mixed together, they form a dough-like consistency that hardens upon exposure to air. PMMA cement has been widely used for decades in joint replacement surgeries, such as hip or knee replacements.
2. Calcium phosphate (CP) cement: This is a two-component system consisting of a powdered CP compound and an aqueous solution. When mixed together, they form a paste that hardens through a chemical reaction at body temperature. CP cement has lower mechanical strength compared to PMMA but demonstrates better biocompatibility, bioactivity, and the ability to resorb over time.

Both types of bone cements have advantages and disadvantages, and their use depends on the specific surgical indication and patient factors.

Biocompatible coated materials refer to surfaces or substances that are treated or engineered with a layer or film designed to interact safely and effectively with living tissues or biological systems, without causing harm or adverse reactions. The coating material is typically composed of biomaterials that can withstand the conditions of the specific application while promoting a positive response from the body.

The purpose of these coatings may vary depending on the medical device or application. For example, they might be used to enhance the lubricity and wear resistance of implantable devices, reduce the risk of infection, promote integration with surrounding tissues, control drug release, or prevent the formation of biofilms.

Biocompatible coated materials must undergo rigorous testing and evaluation to ensure their safety and efficacy in various clinical settings. This includes assessing potential cytotoxicity, genotoxicity, sensitization, hemocompatibility, carcinogenicity, and other factors that could impact the body's response to the material.

Examples of biocompatible coating materials include:

1. Hydrogels: Cross-linked networks of hydrophilic polymers that can be used for drug delivery, tissue engineering, or as lubricious coatings on medical devices.
2. Self-assembling monolayers (SAMs): Organosilane or thiol-based molecules that form a stable, well-ordered film on surfaces, which can be further functionalized to promote specific biological interactions.
3. Poly(ethylene glycol) (PEG): A biocompatible polymer often used as a coating material due to its ability to reduce protein adsorption and cell attachment, making it useful for preventing biofouling or thrombosis on medical devices.
4. Bioactive glass: A type of biomaterial composed of silica-based glasses that can stimulate bone growth and healing when used as a coating material in orthopedic or dental applications.
5. Drug-eluting coatings: Biocompatible polymers impregnated with therapeutic agents, designed to release the drug over time to promote healing, prevent infection, or inhibit restenosis in various medical devices.

Arthroplasty, replacement, is a surgical procedure where a damaged or diseased joint surface is removed and replaced with an artificial implant or device. The goal of this surgery is to relieve pain, restore function, and improve the quality of life for patients who have severe joint damage due to arthritis or other conditions.

During the procedure, the surgeon removes the damaged cartilage and bone from the joint and replaces them with a metal, plastic, or ceramic component that replicates the shape and function of the natural joint surface. The most common types of joint replacement surgery are hip replacement, knee replacement, and shoulder replacement.

The success rate of joint replacement surgery is generally high, with many patients experiencing significant pain relief and improved mobility. However, as with any surgical procedure, there are risks involved, including infection, blood clots, implant loosening or failure, and nerve damage. Therefore, it's essential to discuss the potential benefits and risks of joint replacement surgery with a healthcare provider before making a decision.

A knee prosthesis, also known as a knee replacement or artificial knee joint, is a medical device used to replace the damaged or diseased weight-bearing surfaces of the knee joint. It typically consists of three components: the femoral component (made of metal) that fits over the end of the thighbone (femur), the tibial component (often made of metal and plastic) that fits into the top of the shinbone (tibia), and a patellar component (usually made of plastic) that replaces the damaged surface of the kneecap.

The primary goal of knee prosthesis is to relieve pain, restore function, and improve quality of life for individuals with advanced knee joint damage due to conditions such as osteoarthritis, rheumatoid arthritis, or traumatic injuries. The procedure to implant a knee prosthesis is called knee replacement surgery or total knee arthroplasty (TKA).

Osteoprotegerin (OPG) is a soluble decoy receptor for the receptor activator of nuclear factor kappa-B ligand (RANKL). It is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a crucial role in regulating bone metabolism. By binding to RANKL, OPG prevents it from interacting with its signaling receptor RANK on the surface of osteoclast precursor cells, thereby inhibiting osteoclast differentiation, activation, and survival. This results in reduced bone resorption and increased bone mass.

In addition to its role in bone homeostasis, OPG has also been implicated in various physiological and pathological processes, including immune regulation, cancer progression, and cardiovascular disease.

Dura Mater: The tough, outer membrane that covers the brain and spinal cord.

Hydroxyapatite: A naturally occurring mineral form of calcium apatite, also known as dahllite, with the formula Ca5(PO4)3(OH), is the primary mineral component of biological apatites found in bones and teeth.

Therefore, "Durapatite" isn't a recognized medical term, but it seems like it might be a combination of "dura mater" and "hydroxyapatite." If you meant to ask about a material used in medical or dental applications that combines properties of both dura mater and hydroxyapatite, please provide more context.

A joint prosthesis, also known as an artificial joint or a replacement joint, is a surgical implant used to replace all or part of a damaged or diseased joint. The most common types of joint prostheses are total hip replacements and total knee replacements. These prostheses typically consist of a combination of metal, plastic, and ceramic components that are designed to replicate the movement and function of a natural joint.

Joint prostheses are usually recommended for patients who have severe joint pain or mobility issues that cannot be adequately managed with other treatments such as physical therapy, medication, or lifestyle changes. The goal of joint replacement surgery is to relieve pain, improve joint function, and enhance the patient's quality of life.

Joint prostheses are typically made from materials such as titanium, cobalt-chrome alloys, stainless steel, polyethylene plastic, and ceramics. The choice of material depends on a variety of factors, including the patient's age, activity level, weight, and overall health.

While joint replacement surgery is generally safe and effective, there are risks associated with any surgical procedure, including infection, blood clots, implant loosening or failure, and nerve damage. Patients who undergo joint replacement surgery typically require several weeks of rehabilitation and physical therapy to regain strength and mobility in the affected joint.

Osteitis is a medical term that refers to the inflammation of bone tissue. It can occur as a result of various conditions, such as infection (osteomyelitis), trauma, or autoimmune disorders. The symptoms of osteitis may include pain, swelling, warmth, and redness in the affected area, as well as fever and general malaise. Treatment typically involves addressing the underlying cause of the inflammation, which may involve antibiotics for infection or anti-inflammatory medications for other causes. In some cases, surgery may be necessary to remove infected or damaged bone tissue.

X-ray microtomography, often referred to as micro-CT, is a non-destructive imaging technique used to visualize and analyze the internal structure of objects with high spatial resolution. It is based on the principles of computed tomography (CT), where multiple X-ray images are acquired at different angles and then reconstructed into cross-sectional slices using specialized software. These slices can be further processed to create 3D visualizations, allowing researchers and clinicians to examine the internal structure and composition of samples in great detail. Micro-CT is widely used in materials science, biology, medicine, and engineering for various applications such as material characterization, bone analysis, and defect inspection.

The femur is the medical term for the thigh bone, which is the longest and strongest bone in the human body. It connects the hip bone to the knee joint and plays a crucial role in supporting the weight of the body and allowing movement during activities such as walking, running, and jumping. The femur is composed of a rounded head, a long shaft, and two condyles at the lower end that articulate with the tibia and patella to form the knee joint.

Asepsis is a state or practice of being free from infection or contamination, especially by pathogenic microorganisms. It is a set of procedures and practices used in medicine and healthcare to prevent infection and the spread of disease-causing microorganisms. Aseptic techniques include the use of sterile equipment, barriers, and environmental controls to prevent the introduction of microorganisms into a susceptible host.

There are two types of asepsis: medical and surgical. Medical asepsis involves practices that reduce the number of microorganisms in the environment, such as hand hygiene, use of personal protective equipment (PPE), and cleaning and disinfection of surfaces and equipment. Surgical asepsis is a more stringent form of asepsis that aims to create a sterile field during surgical procedures, using sterilized instruments, drapes, gowns, gloves, and other materials to prevent the introduction of microorganisms into the surgical site.

Maintaining aseptic techniques is critical in healthcare settings to prevent the transmission of infectious agents and protect patients from harm. Failure to follow aseptic practices can result in healthcare-associated infections (HAIs), which can cause significant morbidity, mortality, and increased healthcare costs.

Chromium alloys are materials made by combining chromium with other metals, such as nickel, cobalt, or iron. The addition of chromium to these alloys enhances their properties, making them resistant to corrosion and high temperatures. These alloys have a wide range of applications in various industries, including automotive, aerospace, and medical devices.

Chromium alloys can be classified into two main categories: stainless steels and superalloys. Stainless steels are alloys that contain at least 10.5% chromium by weight, which forms a passive oxide layer on the surface of the material, protecting it from corrosion. Superalloys, on the other hand, are high-performance alloys designed to operate in extreme environments, such as jet engines and gas turbines. They contain significant amounts of chromium, along with other elements like nickel, cobalt, and molybdenum.

Chromium alloys have several medical applications due to their excellent properties. For instance, they are used in surgical instruments, dental implants, and orthopedic devices because of their resistance to corrosion and biocompatibility. Additionally, some chromium alloys exhibit superelasticity, a property that allows them to return to their original shape after being deformed, making them suitable for use in stents and other medical devices that require flexibility and durability.

The femoral head is the rounded, ball-like top portion of the femur (thigh bone) that fits into the hip socket (acetabulum) to form the hip joint. It has a smooth, articular cartilage surface that allows for smooth and stable articulation with the pelvis. The femoral head is connected to the femoral neck, which is a narrower section of bone that angles downward and leads into the shaft of the femur. Together, the femoral head and neck provide stability and range of motion to the hip joint.

Receptor Activator of Nuclear Factor-kappa B (RANK) is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily. It plays a crucial role in the regulation of bone metabolism through the activation of osteoclasts, which are cells responsible for bone resorption.

When RANK binds to its ligand, RANKL (Receptor Activator of Nuclear Factor-kappa B Ligand), it triggers a series of intracellular signaling events that lead to the activation and differentiation of osteoclast precursors into mature osteoclasts. This process is essential for maintaining bone homeostasis, as excessive osteoclast activity can result in bone loss and diseases such as osteoporosis.

In addition to its role in bone metabolism, RANK has also been implicated in the regulation of immune responses, as it is involved in the activation and differentiation of dendritic cells and T cells. Dysregulation of RANK signaling has been associated with various pathological conditions, including autoimmune diseases and cancer.

Hip injuries refer to damages or harm caused to the hip joint or its surrounding structures, including bones, muscles, tendons, ligaments, and cartilage. These injuries can occur due to various reasons such as falls, accidents, sports-related activities, or degenerative conditions. Common hip injuries include fractures, dislocations, strains, sprains, bursitis, and labral tears. Symptoms may include pain, swelling, bruising, stiffness, limited mobility, and inability to bear weight on the affected leg. Proper diagnosis and treatment are crucial to ensure optimal recovery and prevent long-term complications.

Osteoarthritis (OA) of the hip is a degenerative joint disease that affects the articular cartilage and subchondral bone of the hip joint. It is characterized by the progressive loss of cartilage, remodeling of bone, osteophyte formation (bone spurs), cysts, and mild to moderate inflammation. The degenerative process can lead to pain, stiffness, limited range of motion, and crepitus (grating or crackling sound) during movement.

In the hip joint, OA typically affects the femoral head and acetabulum. As the articular cartilage wears away, the underlying bone becomes exposed and can lead to bone-on-bone contact, which is painful. The body responds by attempting to repair the damage through remodeling of the subchondral bone and formation of osteophytes. However, these changes can further limit joint mobility and exacerbate symptoms.

Risk factors for OA of the hip include age, obesity, genetics, previous joint injury or surgery, and repetitive stress on the joint. Treatment options may include pain management (such as NSAIDs, physical therapy, and injections), lifestyle modifications (such as weight loss and exercise), and, in severe cases, surgical intervention (such as hip replacement).

The tarsal bones are a group of seven articulating bones in the foot that make up the posterior portion of the foot, located between the talus bone of the leg and the metatarsal bones of the forefoot. They play a crucial role in supporting the body's weight and facilitating movement.

There are three categories of tarsal bones:

1. Proximal row: This includes the talus, calcaneus (heel bone), and navicular bones. The talus articulates with the tibia and fibula to form the ankle joint, while the calcaneus is the largest tarsal bone and forms the heel. The navicular bone is located between the talus and the cuneiform bones.

2. Intermediate row: This includes the cuboid bone, which is located laterally (on the outside) to the navicular bone and articulates with the calcaneus, fourth and fifth metatarsals, and the cuneiform bones.

3. Distal row: This includes three cuneiform bones - the medial, intermediate, and lateral cuneiforms - which are located between the navicular bone proximally and the first, second, and third metatarsal bones distally. The medial cuneiform is the largest of the three and articulates with the navicular bone, first metatarsal, and the intermediate cuneiform. The intermediate cuneiform articulates with the medial and lateral cuneiforms and the second metatarsal. The lateral cuneiform articulates with the intermediate cuneiform, cuboid, and fourth metatarsal.

Together, these bones form a complex network of joints that allow for movement and stability in the foot. Injuries or disorders affecting the tarsal bones can result in pain, stiffness, and difficulty walking.

Osseointegration is a direct structural and functional connection between living bone and the surface of an implant. It's a process where the bone grows in and around the implant, which is typically made of titanium or another biocompatible material. This process provides a solid foundation for dental prosthetics, such as crowns, bridges, or dentures, or for orthopedic devices like artificial limbs. The success of osseointegration depends on various factors, including the patient's overall health, the quality and quantity of available bone, and the surgical technique used for implant placement.

Equipment Failure Analysis is a process of identifying the cause of failure in medical equipment or devices. This involves a systematic examination and evaluation of the equipment, its components, and operational history to determine why it failed. The analysis may include physical inspection, chemical testing, and review of maintenance records, as well as assessment of design, manufacturing, and usage factors that may have contributed to the failure.

The goal of Equipment Failure Analysis is to identify the root cause of the failure, so that corrective actions can be taken to prevent similar failures in the future. This is important in medical settings to ensure patient safety and maintain the reliability and effectiveness of medical equipment.

In the field of medicine, ceramics are commonly referred to as inorganic, non-metallic materials that are made up of compounds such as oxides, carbides, and nitrides. These materials are often used in medical applications due to their biocompatibility, resistance to corrosion, and ability to withstand high temperatures. Some examples of medical ceramics include:

1. Bioceramics: These are ceramic materials that are used in medical devices and implants, such as hip replacements, dental implants, and bone grafts. They are designed to be biocompatible, which means they can be safely implanted into the body without causing an adverse reaction.
2. Ceramic coatings: These are thin layers of ceramic material that are applied to medical devices and implants to improve their performance and durability. For example, ceramic coatings may be used on orthopedic implants to reduce wear and tear, or on cardiovascular implants to prevent blood clots from forming.
3. Ceramic membranes: These are porous ceramic materials that are used in medical filtration systems, such as hemodialysis machines. They are designed to selectively filter out impurities while allowing essential molecules to pass through.
4. Ceramic scaffolds: These are three-dimensional structures made of ceramic material that are used in tissue engineering and regenerative medicine. They provide a framework for cells to grow and multiply, helping to repair or replace damaged tissues.

Overall, medical ceramics play an important role in modern healthcare, providing safe and effective solutions for a wide range of medical applications.

Diphosphonates are a class of medications that are used to treat bone diseases, such as osteoporosis and Paget's disease. They work by binding to the surface of bones and inhibiting the activity of bone-resorbing cells called osteoclasts. This helps to slow down the breakdown and loss of bone tissue, which can help to reduce the risk of fractures.

Diphosphonates are typically taken orally in the form of tablets, but some forms may be given by injection. Commonly prescribed diphosphonates include alendronate (Fosamax), risedronate (Actonel), and ibandronate (Boniva). Side effects of diphosphonates can include gastrointestinal symptoms such as nausea, heartburn, and abdominal pain. In rare cases, they may also cause esophageal ulcers or osteonecrosis of the jaw.

It is important to follow the instructions for taking diphosphonates carefully, as they must be taken on an empty stomach with a full glass of water and the patient must remain upright for at least 30 minutes after taking the medication to reduce the risk of esophageal irritation. Regular monitoring of bone density and kidney function is also recommended while taking these medications.

Angiomatosis is a medical term that refers to a benign condition characterized by the proliferation of blood vessels in various tissues and organs. It is typically composed of small, tangled blood vessels called capillaries, which can form clusters or networks. The condition can affect skin, internal organs, bones, and other tissues.

Angiomatosis is often asymptomatic and may be discovered incidentally during medical imaging or surgical procedures. In some cases, it may cause symptoms such as pain, swelling, or bleeding, depending on the location and extent of the lesions.

While angiomatosis is generally a benign condition, in rare cases, it can be associated with malignant tumors or other medical conditions. Treatment options for angiomatosis depend on the size, location, and symptoms of the lesions and may include observation, medication, or surgical removal.

A foreign-body reaction is an immune response that occurs when a non-native substance, or "foreign body," is introduced into the human body. This can include things like splinters, surgical implants, or even injected medications. The immune system recognizes these substances as foreign and mounts a response to try to eliminate them.

The initial response to a foreign body is often an acute inflammatory reaction, characterized by the release of chemical mediators that cause vasodilation, increased blood flow, and the migration of white blood cells to the site. This can result in symptoms such as redness, swelling, warmth, and pain.

If the foreign body is not eliminated, a chronic inflammatory response may develop, which can lead to the formation of granulation tissue, fibrosis, and encapsulation of the foreign body. In some cases, this reaction can cause significant tissue damage or impede proper healing.

It's worth noting that not all foreign bodies necessarily elicit a strong immune response. The nature and size of the foreign body, as well as its location in the body, can all influence the severity of the reaction.

Femoral head necrosis, also known as avascular necrosis of the femoral head, is a medical condition that results from the interruption of blood flow to the femoral head, which is the rounded end of the thigh bone that fits into the hip joint. This lack of blood supply can cause the bone tissue to die, leading to the collapse of the femoral head and eventually resulting in hip joint damage or arthritis.

The condition can be caused by a variety of factors, including trauma, alcohol abuse, corticosteroid use, radiation therapy, and certain medical conditions such as sickle cell disease and lupus. Symptoms may include pain in the hip or groin, limited range of motion, and difficulty walking. Treatment options depend on the severity and progression of the necrosis and may include medication, physical therapy, or surgical intervention.

A granuloma is a type of organized immune response that occurs when the body encounters a foreign substance that it cannot eliminate. A "foreign-body" granuloma specifically refers to this reaction in response to an exogenous material, such as a splinter, suture, or other types of medical implants.

Foreign-body granulomas are characterized by the formation of a collection of immune cells, including macrophages and lymphocytes, which surround and attempt to isolate the foreign material. Over time, this collection of immune cells can become walled off and form a well-circumscribed mass or nodule.

Foreign-body granulomas may cause localized symptoms such as pain, swelling, or inflammation, depending on their location and size. In some cases, they may also lead to complications such as infection or tissue damage. Treatment typically involves removing the foreign body, if possible, followed by anti-inflammatory therapy to manage any residual symptoms or complications.

Tantalum is not a medical term, but a chemical element with the symbol Ta and atomic number 73. It is a rare, hard, blue-gray, lustrous transition metal that is highly corrosion-resistant. In the field of medicine, tantalum is often used in the production of medical implants such as surgical pins, screws, plates, and stents due to its biocompatibility and resistance to corrosion. For example, tantalum mesh is used in hernia repair and tantalum rods are used in spinal fusion surgery.

Osteonecrosis is a medical condition characterized by the death of bone tissue due to the disruption of blood supply. Also known as avascular necrosis, this process can lead to the collapse of the bone and adjacent joint surfaces, resulting in pain, limited mobility, and potential deformity if left untreated. Osteonecrosis most commonly affects the hips, shoulders, and knees, but it can occur in any bone. The condition may be caused by trauma, corticosteroid use, alcohol abuse, certain medical conditions (like sickle cell disease or lupus), or for no apparent reason (idiopathic).

Cathepsin K is a proteolytic enzyme, which belongs to the family of papain-like cysteine proteases. It is primarily produced by osteoclasts, which are specialized cells responsible for bone resorption. Cathepsin K plays a crucial role in the degradation and remodeling of the extracellular matrix, particularly in bone tissue.

This enzyme is capable of breaking down various proteins, including collagen, elastin, and proteoglycans, which are major components of the bone matrix. By doing so, cathepsin K helps osteoclasts to dissolve and remove mineralized and non-mineralized bone matrix during the process of bone resorption.

Apart from its function in bone metabolism, cathepsin K has also been implicated in several pathological conditions, such as osteoporosis, rheumatoid arthritis, and tumor metastasis to bones. Inhibitors of cathepsin K are being investigated as potential therapeutic agents for the treatment of these disorders.

Chylothorax is a medical condition characterized by the accumulation of lymphatic fluid called chyle in the pleural space, which is the space between the lungs and the chest wall. Chyle is a milky-white fluid that contains nutrients, electrolytes, and immune cells, and it is normally transported through the thoracic duct to the bloodstream.

Chylothorax can occur due to various reasons, such as trauma, surgery, tumors, or congenital abnormalities that disrupt the normal flow of chyle. As a result, chyle leaks into the pleural space, causing symptoms such as cough, chest pain, difficulty breathing, and fever.

The diagnosis of chylothorax is usually made through imaging studies such as chest X-ray or CT scan, and confirmed by analyzing the fluid for the presence of chylomicrons, which are lipid particles found in chyle. The treatment options for chylothorax include dietary modifications, such as a low-fat diet with medium-chain triglycerides, chest tube drainage, and surgical interventions such as thoracic duct ligation or pleurodesis.

Biocompatible materials are non-toxic and non-reacting substances that can be used in medical devices, tissue engineering, and drug delivery systems without causing harm or adverse reactions to living tissues or organs. These materials are designed to mimic the properties of natural tissues and are able to integrate with biological systems without being rejected by the body's immune system.

Biocompatible materials can be made from a variety of substances, including metals, ceramics, polymers, and composites. The specific properties of these materials, such as their mechanical strength, flexibility, and biodegradability, are carefully selected to meet the requirements of their intended medical application.

Examples of biocompatible materials include titanium used in dental implants and joint replacements, polyethylene used in artificial hips, and hydrogels used in contact lenses and drug delivery systems. The use of biocompatible materials has revolutionized modern medicine by enabling the development of advanced medical technologies that can improve patient outcomes and quality of life.

Carpal bones are the eight small bones that make up the wrist joint in humans and other primates. These bones are arranged in two rows, with four bones in each row. The proximal row includes the scaphoid, lunate, triquetral, and pisiform bones, while the distal row includes the trapezium, trapezoid, capitate, and hamate bones.

The carpal bones play an essential role in the function of the wrist joint by providing stability, support, and mobility. They allow for a wide range of movements, including flexion, extension, radial deviation, ulnar deviation, and circumduction. The complex structure of the carpal bones also helps to absorb shock and distribute forces evenly across the wrist during activities such as gripping or lifting objects.

Injuries to the carpal bones, such as fractures or dislocations, can be painful and may require medical treatment to ensure proper healing and prevent long-term complications. Additionally, degenerative conditions such as arthritis can affect the carpal bones, leading to pain, stiffness, and decreased mobility in the wrist joint.

"Bone" is the hard, dense connective tissue that makes up the skeleton of vertebrate animals. It provides support and protection for the body's internal organs, and serves as a attachment site for muscles, tendons, and ligaments. Bone is composed of cells called osteoblasts and osteoclasts, which are responsible for bone formation and resorption, respectively, and an extracellular matrix made up of collagen fibers and mineral crystals.

Bones can be classified into two main types: compact bone and spongy bone. Compact bone is dense and hard, and makes up the outer layer of all bones and the shafts of long bones. Spongy bone is less dense and contains large spaces, and makes up the ends of long bones and the interior of flat and irregular bones.

The human body has 206 bones in total. They can be further classified into five categories based on their shape: long bones, short bones, flat bones, irregular bones, and sesamoid bones.

Arthroplasty, replacement, knee is a surgical procedure where the damaged or diseased joint surface of the knee is removed and replaced with an artificial joint or prosthesis. The procedure involves resurfacing the worn-out ends of the femur (thigh bone) and tibia (shin bone) with metal components, and the back of the kneecap with a plastic button. This surgery is usually performed to relieve pain and restore function in patients with severe knee osteoarthritis, rheumatoid arthritis, or traumatic injuries that have damaged the joint beyond repair. The goal of knee replacement surgery is to improve mobility, reduce pain, and enhance the quality of life for the patient.

The clavicle, also known as the collarbone, is a long, slender bone that lies horizontally between the breastbone (sternum) and the shoulder blade (scapula). It is part of the shoulder girdle and plays a crucial role in supporting the upper limb. The clavicle has two ends: the medial end, which articulates with the sternum, and the lateral end, which articulates with the acromion process of the scapula. It is a common site of fracture due to its superficial location and susceptibility to direct trauma.

Acquired hand deformities refer to structural changes in the hand or fingers that occur after birth, as a result of injury, illness, or other external factors. These deformities can affect any part of the hand, including the bones, joints, muscles, tendons, ligaments, and nerves. Common causes of acquired hand deformities include trauma, infection, degenerative diseases such as arthritis, tumors, and neurological conditions.

The symptoms of acquired hand deformities can vary depending on the severity and location of the deformity. They may include pain, stiffness, swelling, decreased range of motion, loss of function, and changes in appearance. Treatment for acquired hand deformities may involve a combination of medical interventions, such as medication, physical therapy, or splinting, as well as surgical procedures to correct the underlying structural problem. The goal of treatment is to relieve symptoms, improve function, and restore normal appearance and movement to the hand.

Corrosion is a process of deterioration or damage to a material, usually a metal, caused by chemical reactions with its environment. In the medical context, corrosion may refer to the breakdown and destruction of living tissue due to exposure to harsh substances or environmental conditions. This can occur in various parts of the body, such as the skin, mouth, or gastrointestinal tract, and can be caused by factors like acid reflux, infection, or exposure to chemicals.

In the case of medical devices made of metal, corrosion can also refer to the degradation of the device due to chemical reactions with bodily fluids or tissues. This can compromise the function and safety of the device, potentially leading to complications or failure. Therefore, understanding and preventing corrosion is an important consideration in the design and use of medical devices made of metal.

Follow-up studies are a type of longitudinal research that involve repeated observations or measurements of the same variables over a period of time, in order to understand their long-term effects or outcomes. In medical context, follow-up studies are often used to evaluate the safety and efficacy of medical treatments, interventions, or procedures.

In a typical follow-up study, a group of individuals (called a cohort) who have received a particular treatment or intervention are identified and then followed over time through periodic assessments or data collection. The data collected may include information on clinical outcomes, adverse events, changes in symptoms or functional status, and other relevant measures.

The results of follow-up studies can provide important insights into the long-term benefits and risks of medical interventions, as well as help to identify factors that may influence treatment effectiveness or patient outcomes. However, it is important to note that follow-up studies can be subject to various biases and limitations, such as loss to follow-up, recall bias, and changes in clinical practice over time, which must be carefully considered when interpreting the results.

"Acro-osteolysis (mnemonic) , Radiology Reference Article , Radiopaedia.org". Radiopaedia. doi:10.53347/rID-12202. Freedberg, et ... A mnemonic commonly used for acro-osteolysis is PINCHFO.Pyknodysostosis, Psoriasis, Injury (thermal burn, frostbite), ... Acroosteolysis is resorption of the distal bony phalanges. Acroosteolysis has two patterns of resorption in adults: diffuse and ... Acroosteolysis may be associated with minimal skin changes or with ischemic skin lesions that may result in digital necrosis.: ...
High bone density, Acro-osteolysis and obtuse mandibular angle are the characteristic radiological findings of this disorder. ... Skeletal surveys can also aid in clinical diagnosis and characteristic features include high bone density, acro-osteolysis and ...
... associated with scleroderma-like lesions and acro-osteolysis: A case report and brief review of the literature". Pediatric ... Other features include skeletal alterations (osteolysis, osteoporosis), amyotrophy (wasting of muscle), lipodystrophy and skin ...
Hypotrichosis-acro-osteolysis-onychogryphosis-palmoplantar keratoderma-periodontitis syndrome Hypotrichosis-lymphedema- ... palmoplantar keratoderma with periodontitis and arachnodactyly and acro-osteolysis) Hidrotic ectodermal dysplasia (alopecia ... Acroosteolysis Acute paronychia Alopecia areata Alopecia neoplastica Anagen effluvium Androgenic alopecia (androgenetic ... Nicolau-Balus syndrome Nodulosis-arthropathy-osteolysis syndrome Normophosphatemic familial tumoral calcinosis Palisaded ...
Menke's syndrome Cleidocranial dysostosis Hypothyroidism and hypophosphatasia Otopalatodigital syndrome Primary acro-osteolysis ...
... osteolysis MeSH C05.116.264.579.052 - acro-osteolysis MeSH C05.116.264.579.052.400 - Hajdu-Cheney syndrome MeSH C05.116.264.579 ... MeSH C05.116.070.265 - bone cysts, aneurysmal MeSH C05.116.099.052 - acro-osteolysis MeSH C05. - Hajdu-Cheney ... osteolysis, essential MeSH C05.116.540.310 - exostoses MeSH C05.116.540.310.500 - exostoses, multiple hereditary MeSH C05.116. ... osteolysis, essential MeSH C05.116.099.742 - platybasia MeSH C05.116.099.750 - Proteus syndrome MeSH C05.116.132.082 - ...
... ectodermal dysplasia Hypoplastic left heart syndrome Hypoplastic right heart syndrome Hypotonia Hypotrichosis-acro-osteolysis- ... microphthalmia and cataract syndrome Acrocallosal syndrome Acropectoral syndrome Acro-dermato-ungual-lacrimal-tooth syndrome ...
... acro-osteolysis, and equinovarus foot deformities.[citation needed] Singleton, EB, Merten DF: An unusual syndrome of widened ...
... and osteolysis involving the distal phalanges of fingers and toes (acro-osteolysis). Permanent flexion contractures of the ... Haim-Munk syndrome (also known as "palmoplantar keratoderma with periodontitis and arachnodactyly, acro-osteolysis and Cochin ...
... finger circulation disorder resulting in acro-osteolysis (necrosis of the first phalanxes), as well as headaches and dizziness ...
"Acro-osteolysis (mnemonic) , Radiology Reference Article , Radiopaedia.org". Radiopaedia. doi:10.53347/rID-12202. Freedberg, et ... A mnemonic commonly used for acro-osteolysis is PINCHFO.Pyknodysostosis, Psoriasis, Injury (thermal burn, frostbite), ... Acroosteolysis is resorption of the distal bony phalanges. Acroosteolysis has two patterns of resorption in adults: diffuse and ... Acroosteolysis may be associated with minimal skin changes or with ischemic skin lesions that may result in digital necrosis.: ...
a. Acro-osteolysis. b. Ergot. c. Nicotine. d. Vinyl chloride. 6. Neurogenic. a. Poliomyelitis. b. Syringomyelia. c. Hemiplegia ...
Loss of bone tissue from the hands and feet (acro-osteolysis) is a characteristic feature of the condition. The fingers and ... Many of the disorders features, such as acro-osteolysis and some of the characteristic facial features, are not present at ... They suspect that the skeletal features of the disorder, including acro-osteolysis, osteoporosis. , and distinctive facial ...
... acro osteolysis; sclerodermoid changes; discolorations of hair, skin or nails; and porphyria cutanea tarda. Various occupations ...
Note the soft-tissue clubbing and acro-osteolysis of the terminal phalanges. View Media Gallery ... Note the soft-tissue clubbing and acro-osteolysis of the terminal phalanges. View Media Gallery ... Note the soft-tissue clubbing and acro-osteolysis of the terminal phalanges. ... which is termed acro-osteolysis. This finding is generally associated with primary HOA and congenital cyanotic heart disease. ...
... and bilateral acro-osteolysis with amputated digits.. (30). 2021. Mexico. F/32. DLL + ENL. Current patient. M. lepromatosis. ...
Pamidronate does not improve peripheral osteolysis in multicentric osteolysis and nodular arthropathy caused by a mutation in ... Kozlowski K, Barylak A, Eftekhari F, Pasyk K, Wislocka E. Acroosteolysis. Problems of diagnosis--report of four cases. Pediatr ... Idiopathic multicentric osteolysis: report of two new cases and a review of the literature. Am J Med Genet. 1988 Apr. 29(4):929 ... Idiopathic multicentric osteolysis. AJR Am J Roentgenol. 1976 Jan. 126(1):23-31. [QxMD MEDLINE Link]. ...
Even if resorption of the distal phalangeal joints (acro-osteolysis) is a typical finding in SSc, joint erosions are rare in ...
Generalized brachydactyly with acro-osteolysis was observed. Flexion contractures limited his daily activities. Cognitive ... Acro-Osteólise , Anormalidades da Pele , Acro-Osteólise/genética , Dasatinibe/uso terapêutico , Humanos , Mesilato de Imatinib/ ...
Hajdu-Cheney Syndrome (HCS) is a rare hereditary bone metabolism disorder characterized by acro-osteolysis, short stature, ...
Idiopathic multicentric osteolysis: report of two new cases and a review of the literature. Am J Med Genet. 1988 Apr. 29(4):929 ... Kozlowski K, Barylak A, Eftekhari F, Pasyk K, Wislocka E. Acroosteolysis. Problems of diagnosis--report of four cases. Pediatr ... Idiopathic multicentric osteolysis. AJR Am J Roentgenol. 1976 Jan. 126(1):23-31. [QxMD MEDLINE Link]. ... Carpal and tarsal osteolysis. Pediatr Radiol. 1983. 13(4):219-26. [QxMD MEDLINE Link]. ...
Idiopathic multicentric osteolysis: report of two new cases and a review of the literature. Am J Med Genet. 1988 Apr. 29(4):929 ... Kozlowski K, Barylak A, Eftekhari F, Pasyk K, Wislocka E. Acroosteolysis. Problems of diagnosis--report of four cases. Pediatr ... Idiopathic multicentric osteolysis. AJR Am J Roentgenol. 1976 Jan. 126(1):23-31. [QxMD MEDLINE Link]. ... 14] Torg syndrome, nodulosis-arthropathy-osteolysis, and Winchester syndrome may be allelic disorders. [15] These 2 syndromes ...
Itll actually create whats called acro osteo lysis basically the tips of your fingers, the bones dissolve into nothing. [13.5 ...
Case 179 Psoriatic arthritis with acro-osteolysis Case 180 Fahr syndrome Case 181 Pseudohypoparathyroidism ...
1824c acro affiliated alopecia bossing chin clavicles contracture extremities g608g gilford groove hgps horse huazhong ... clavicles contracture extremities g608g gilford groove hgps horse huazhong hutchinson joints micrognathia midline osteolysis ... hutchinson joints micrognathia midline osteolysis phalanges progeria radiographical riding sclerodermatous stance stature ...
... associated with acro-osteolysis of the distal phalanges, short stature, distinctive craniofacial and skull changes, premature ...
Acro-Osteolysis [C05.116.099.052] Acro-Osteolysis * Basal Cell Nevus Syndrome [C05.116.099.105] ...
Acro-osteolysis. Ambiguous genitalia. Anodontia or hypodontia. Arachnodactyly. Band-like erosion of the midportion of a ... Acro-osteolysis. Ambiguous genitalia. Anodontia or hypodontia. Arachnodactyly. Band-like erosion of the midportion of a ...
Hajdu-Cheney Syndrome: A Report on Successful Halting of Acro-osteolysis Gopinath Duraiswamy 1 , Munis Ashraf 2 , Senthil ... Hajdu-Cheney Syndrome: A Report on Successful Halting of Acro-osteolysis Gopinath Duraiswamy et al. JBJS Case Connect. 2021. . ... A very rare cause of acro-osteolysis: Hajdu-Cheney syndrome. Deprouw C, Feydy A, Giraudet Le Quintrec JS, Ruiz B, Kahan A, ... A case of Hajdu-Cheney syndrome associated with psoriatic rheumatism, two causes of acro-osteolysis. Rochoux Q, Léon N, Bréhin ...
Hereditary osteodysplasia with acro-osteolysis, see Hajdu-Cheney syndrome. *Hereditary pancreatitis. *Hereditary paraganglioma- ... Hereditary multicentric osteolysis, see Multicentric osteolysis, nodulosis, and arthropathy. *Hereditary multiple benign cystic ...
Acro-osteolysis ; Acroosteolysis ; Breakdown of small bones of fingers Alternate IDs:. HP:0001179 ... Osteolysis of scaphoids Osteolytic defects of the phalanges of the hand + Dissolution or degeneration of bone tissue of the ...
Occupational acro-osteolysis. J Bone Joint Surg Am 60:86-90. 624763. . Crossref, Medline, Google Scholar ...
Synonym: Acro-Osteolysis. Synonym: Acroosteolysis. Synonym: Breakdown of Small Bones of Fingers ...
Sarcoidosis-associated acro-osteolysis.. Patel V; Case R; Kalra S; Patel D. BMJ Case Rep; 2021 Mar; 14(3):. PubMed ID: 33653863 ...
Acroosteolysis dominant type, see Hajdu-Cheney syndrome. *Acroosteolysis with osteoporosis and changes in skull and mandible, ... Al-Aqeel Sewairi syndrome, see Multicentric osteolysis, nodulosis, and arthropathy. *Alacrima-achalasia-adrenal insufficiency ...
... and acro-osteolysis. Subjects may suffer severe neurological complications, and HCS presents with cardiovascular defects and ... but not necessarily the acro-osteolysis. In conclusion, HCS is a devastating disease associated with a gain-of-NOTCH2 function ... Denosumab Treatment Does Not Halt Progression of Bone Lesions in Multicentric Carpotarsal Osteolysis Syndrome. Lerman MA, ...
Acro - osteolysis - resorption of the distal phalanx. - In the Spine, Sacroi-liitis is common - unilat-erally, bilateral but ...
Acro-osteolysis. *. Osteopetrosis; radio-opacity of all bones ↑ due to ↑ density of trabecular bone but not cortices ...
acroosteolysis, acro-osteolysis (s) (noun, ), acroosteolyses; acro-osteolyses (pl) A degeneration of bone tissue, or the ... softening and destruction of bone, involving the distal phalanges of the fingers and toes: Acroosteolysis, caused by a disease ...
Acro-Osteolysis Entry term(s). Acro Osteolysis Acro-Osteolysis Syndrome Acro-Osteolysis Syndromes Acroosteolysis Acroosteolysis ... Acro-ostéolyse Entry term(s):. Acro Osteolysis. Acro-Osteolysis Syndrome. Acro-Osteolysis Syndromes. Acroosteolysis. ... Acro-Osteolysis - Preferred Concept UI. M0393325. Scope note. A condition with congenital and acquired forms causing recurrent ... When acro-osteolysis is accompanied by generalized OSTEOPOROSIS and skull deformations, it is called HAJDU-CHENEY SYNDROME.. ...
Acro-Osteolysis Syndromes Acroosteolysis Acroosteolysis Syndrome Previous Indexing. Osteolysis (1966-2002). Osteolysis, ... Osteolysis [C05.116.264.579] * Acro-Osteolysis [C05.116.264.579.052] * Hajdu-Cheney Syndrome [C05.116.264.579.052.400] ... Acroosteolysis Term UI T462487. Date09/19/2001. LexicalTag NON. ThesaurusID Acroosteolysis Syndrome Term UI T029647. Date04/08/ ... Acro-Osteolysis Preferred Term Term UI T029644. Date04/06/1986. LexicalTag NON. ThesaurusID UNK (19XX). ...
Acro-Osteolysis Syndromes Acroosteolysis Acroosteolysis Syndrome Previous Indexing. Osteolysis (1966-2002). Osteolysis, ... Osteolysis [C05.116.264.579] * Acro-Osteolysis [C05.116.264.579.052] * Hajdu-Cheney Syndrome [C05.116.264.579.052.400] ... Acroosteolysis Term UI T462487. Date09/19/2001. LexicalTag NON. ThesaurusID Acroosteolysis Syndrome Term UI T029647. Date04/08/ ... Acro-Osteolysis Preferred Term Term UI T029644. Date04/06/1986. LexicalTag NON. ThesaurusID UNK (19XX). ...
Occupational acro-osteolysis Current Synonym true false 98568015 Occupational acroosteolysis Current Synonym true false ... Occupational acroosteolysis (disorder) {59342007 , SNOMED-CT } Parent/Child (Relationship Type) Vinyl chloride disease ( ...
Acro-Osteolysis,syndrome, acro-osteolysis Function Tests, Ovarian,function tests, ovarian Pacemaker, cardiac,pacemaker, cardiac ...
Cook, W. A., Giever, P. M., Dinman, B. D., and Magnuson, H. J. Occupational acro-osteolysis II: An industrial hygiene study. ...
Predictors of Acro-Osteolysis in Systemic Sclerosis. *Abstract Number: 2233. Predictors of Adherence and Costs in First and ...
Pamidronate does not improve peripheral osteolysis in multicentric osteolysis and nodular arthropathy caused by a mutation in ... Kozlowski K, Barylak A, Eftekhari F, Pasyk K, Wislocka E. Acroosteolysis. Problems of diagnosis--report of four cases. Pediatr ... Idiopathic multicentric osteolysis: report of two new cases and a review of the literature. Am J Med Genet. 1988 Apr. 29(4):929 ... Idiopathic multicentric osteolysis. AJR Am J Roentgenol. 1976 Jan. 126(1):23-31. [QxMD MEDLINE Link]. ...
16] Hypertrophy or bony overgrowth predominates in patients with HOA secondary to lung cancer, whereas acro-osteolysis ... 16] If clubbing appears in childhood, osteolysis is more prominent; however, if it develops after puberty, hypertrophic changes ...
Acro-Osteolysis,Syndrome, Acro-Osteolysis Function Tests, Ovarian,Function Tests, Ovarian Pacemaker, cardiac,Pacemaker, cardiac ...
ACRO-OSTEOLYSIS of distal phalanges, dental and MAXILLOFACIAL ABNORMALITIES and an increase in bone density that results in ...
... acro-osteolysis, and auto-amputation. There is definitely room to improve on our current treatment paradigm." ...
acro-osteolysis *acromegaly *amyloidosis: bone manifestations *Andersson lesion *aneurysmal bone cyst *ankle anatomy * ... spontaneous osteolysis *Sprengel deformity *Still disease *subluxation without erosion *synovial osteochondromatosis *synovial ...
  • Pamidronate does not improve peripheral osteolysis in multicentric osteolysis and nodular arthropathy caused by a mutation in the matrix metalloproteinase 2 gene. (medscape.com)
  • Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. (medscape.com)
  • Hajdu-Cheney Syndrome (HCS) is a rare hereditary bone metabolism disorder characterized by acro-osteolysis, short stature, craniofacial changes, periodontitis and premature tooth loss. (opendentistryjournal.com)
  • In the case of long-standing clubbing, bone remodeling can cause osseous resorption at the terminal phalanges of the fingers and toes, which is termed acro-osteolysis. (medscape.com)
  • Loss of bone tissue from the hands and feet (acro-osteolysis) is a characteristic feature of the condition. (medlineplus.gov)
  • Acroosteolysis is resorption of the distal bony phalanges. (wikipedia.org)
  • Note the soft-tissue clubbing and acro-osteolysis of the terminal phalanges. (medscape.com)
  • HCS is characterized by craniofacial developmental defects, including platybasia and wormian bones, osteoporosis with fractures, and acro-osteolysis. (nih.gov)
  • Intensified symptoms of osteoporosis, including osteolysis of the carpal and tarsal bones, causes destructive changes in the joints of the hands and wrists, as well as in the joints of the tarsus and foot. (medscape.com)
  • When acro-osteolysis is accompanied by generalized OSTEOPOROSIS and skull deformations, it is called HAJDU-CHENEY SYNDROME. (bvsalud.org)
  • A case of Hajdu-Cheney syndrome associated with psoriatic rheumatism, two causes of acro-osteolysis. (nih.gov)
  • Loss of bone tissue from the hands and feet (acro-osteolysis) is a characteristic feature of the condition. (medlineplus.gov)
  • Many of the disorder's features, such as acro-osteolysis and some of the characteristic facial features, are not present at birth but become apparent in childhood or later. (medlineplus.gov)