Acridones: Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. Many of them are naturally occurring alkaloids.Rutaceae: A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.AcridinesAcetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)Rosales: An order of the ANGIOSPERMS, subclass Rosidae. Its members include some of the most known ornamental and edible plants of temperate zones including roses, apples, cherries, and peaches.Alkaloids: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Thioxanthenes: Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.Dianthus: A plant genus of the family CARYOPHYLLACEAE. Members contain dianthins, which are ribosome inactivating proteins.Nucleotide Motifs: Commonly observed BASE SEQUENCE or nucleotide structural components which can be represented by a CONSENSUS SEQUENCE or a SEQUENCE LOGO.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Bacteriology: The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Australia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Drug Discovery: The process of finding chemicals for potential therapeutic use.Neglected Diseases: Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. The World Health Organization has designated six tropical infectious diseases as being neglected in industrialized countries that are endemic in many developing countries (HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA).Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Combinatorial Chemistry Techniques: A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.Students, Pharmacy: Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.Chemical Industry: The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Medicare Assignment: Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.Insurance, Health, Reimbursement: Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988)Competitive Bidding: Pricing statements presented by more than one party for the purpose of securing a contract.Purchasing, Hospital: Hospital department responsible for the purchasing of supplies and equipment.Chlorine Compounds: Inorganic compounds that contain chlorine as an integral part of the molecule.Sphingosine: An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)Phosphotransferases (Alcohol Group Acceptor): A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. EC 2.7.1.Lysophospholipids: Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Receptors, Lysosphingolipid: A subfamily of lysophospholipid receptors with specificity for LYSOSPHINGOLIPIDS such as sphingosine-1-phosphate and sphingosine phosphorylcholine.Propylene Glycols: Derivatives of propylene glycol (1,2-propanediol). They are used as humectants and solvents in pharmaceutical preparations.Curriculum: A course of study offered by an educational institution.United StatesSphingolipids: A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)Ceramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.
(1/13) Interactions of antitumor triazoloacridinones with DNA.

Triazoloacridinones (TA) are a new group of potent antitumor compounds, from which the most active derivative, C-1305, has been selected for extended preclinical trials. This study investigated the mechanism of TA binding to DNA. Initially, for selected six TA derivatives differing in chemical structures as well as cytotoxicity and antitumor activity, the capability of noncovalent DNA binding was analyzed. We showed that all triazoloacridinones studied stabilized the DNA duplex at a low-concentration buffer but not at a salt concentration corresponding to that in cells. DNA viscometric studies suggested that intercalation to DNA did not play a major role in the mechanism of the cytotoxic action of TA. Studies involving cultured cells revealed that triazoloacridinone C-1305 after previous metabolic activation induced the formation of interstrand crosslinks in DNA of some tumor and fibroblast cells in a dose dependent manner. However, the detection of crosslink formation was possible only when the activity of topoisomerase II in cells was lowered. Furthermore, it was impossible to validate the relevance of the ability to crosslink DNA to biological activity of TA derivatives.  (+info)

(2/13) Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.

A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. A number of acridone derivatives, with side chains bridged three or more carbon atoms apart between the ring nitrogen and terminal nitrogen, demonstrated chloroquine (CQ)-chemosensitizing activity against the MDR strain of P. falciparum (Dd2). Isobologram analysis revealed that selected candidates demonstrated significant synergy with CQ in the CQ-resistant (CQR) parasite Dd2 but only additive (or indifferent) interaction in the CQ-sensitive (CQS) D6. These acridone derivatives also enhanced the sensitivity of other quinoline antimalarials, such as desethylchloroquine (DCQ) and quinine (QN), in Dd2. The patterns of chemosensitizing effects of selected acridones on CQ and QN were similar to those of verapamil against various parasite lines with mutations encoding amino acid 76 of the P. falciparum CQ resistance transporter (PfCRT). Unlike other known chemosensitizers with recognized psychotropic effects (e.g., desipramine, imipramine, and chlorpheniramine), these novel acridone derivatives exhibited no demonstrable effect on the uptake or binding of important biogenic amine neurotransmitters. The combined results indicate that 10-N-substituted acridones present novel pharmacophores for the development of chemosensitizers against P. falciparum.  (+info)

(3/13) Antitumour properties of acridone alkaloids on a murine lymphoma cell line.

The aim of the present study was to investigate the anticancer properties of a set of furanoacridone alkaloids, arborinine and evoxanthine, including the inhibitory effect of P-glycoprotein (Pgp) and the apoptosis-inducing capacity. The tested alkaloids were evaluated for multidrug resistance (MDR)-reversing activity on human Pgp-transfected L5178 mouse lymphoma cells, using the rhodamine-123 (Rh-123) assay. The antiproliferative effects of natural compounds and their interactions with doxorubicin were determined in MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays. Apoptosis-inducing activity was additionally measured by means of dual annexin V and propidium iodide staining. RT-PCR was used to test the expression of Pgp mRNA after acridone treatment. All of the acridones investigated increased the accumulation of Rh-123. Gravacridonetriol and gravacridonediol monomethyl ether increased the antiproliferative effect of doxorubicin on resistant L5178 cells. Treatment with these agents resulted in a decrease in Pgp mRNA levels. Naturally occurring acridone alkaloids exhibit a beneficial combination of anticancer effects and, accordingly, the acridone skeleton can be considered useful in the design of novel antiproliferative agents.  (+info)

(4/13) A new acridone alkaloid from Micromelum integerrimum.

A new acridone alkaloid, 1,3-dihydroxy-4-methoxy-10-methylacridone (1), was isolated from leaves of the plant Micromelum integerrimum, together with two known carbazole alkaloids, glycozolinol (2) and methyl carbazole-3-carboxylate (3). Their structures were elucidated by extensive spectroscopic analysis.  (+info)

(5/13) Fluorescent properties of acridonyl group in DNA duplex.

 (+info)

(6/13) Isolation of acridone alkaloids and N-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives from Glycosmis parva and their anti-herpes simplex virus activity.

Six acridone alkaloids including a new glycosparvarine (1), three limonoids, and four N-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives including two new species, (+)-S-deoxydihydroglyparvin (10) and (+)-S-deoxytetrahydroglyparvin (11), were isolated from the branches and the leaves of Glycosmis parva CRAIB collected in the east of Thailand. Antiviral activity evaluation of isolates against herpes simplex virus (HSV) type 1 and 2 disclosed that two acridone alkaloids, glycosparvarine (1) and glycofolinine (4), showed moderate inhibitory activities with 50% effective concentration (EC50) of 348 microM and 151 microM, respectively; as well, (+)-S-deoxydihydroglyparvin (10) exhibited anti-HSV activity at the lower concentration.  (+info)

(7/13) Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.

Acridine derivatives constitute a class of compounds that are being intensively studied as potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; however, their clinical application is limited or even excluded because of side effects. Numerous synthetic methods are focused on the preparation of target acridine skeletons or modifications of naturally occurring compounds, such as acridone alkaloids, that exhibit promising anticancer activities. They have been examined in vitro and in vivo to test their importance for cancer treatment and to establish the mechanism of action at both the molecular and cellular level, which is necessary for the optimization of their properties so that they are suitable in chemotherapy. In this article, we review natural and synthetic acridine/acridone analogs, their application as anticancer drugs and methods for their preparation.  (+info)

(8/13) Synthesis of o-(dimethylamino)aryl ketones and acridones by the reaction of 1,1-dialkylhydrazones and arynes.

 (+info)

*  Acridone
... is an organic compound based on the acridine skeleton, with a carbonyl group at the 9 position. It may be synthesized ... Acridone constitutes the scaffold of some synthetic compounds with various pharmacological activities. Most recent derivatives ... 2-chloroacridone is the precursor used to make clomacran (tranquilizer). C. F. H. Allen; G. H. W. McKee (1943). "Acridone". ... "In Vitro and In Vivo Activities of Atalaphillinine and Related Acridone Alkaloids against Rodent Malaria". Antimicrobial Agents ...
*  Acridone synthase
In enzymology, an acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + N- ... Baumert A, Maier W, Groger D, Deutzmann R (1994). "Purification and properties of acridone synthase from cell suspension ... Junghanns KT, Kneusel RE, Groger D, Matern U (1998). "Differential regulation and distribution of acridone synthase in Ruta ... "Native acridone synthases I and II from Ruta graveolens L. form homodimers". FEBS Lett. 448 (1): 135-40. doi:10.1016/S0014-5793 ...
*  Ullmann condensation
An example of a Goldberg reaction is the synthesis of fenamic acid, an intermediate of acridone via the Goldberg reaction: An ... 2003 WO02/085838 Link[permanent dead link] C. F. H. Allen and G. H. W. McKee (1943). "Acridone". Organic Syntheses. ; ...
*  Lucigenin
It may be prepared from acridone. There's also a route from toluene:. ...
*  Anthranilate N-methyltransferase
This enzyme participates in acridone alkaloid biosynthesis. Eilert U; Wolters B (1989). "Elicitor induction of S-adenosyl-L- ...
*  Acridine
Another classic method for the synthesis of acridones is the Lehmstedt-Tanasescu reaction. In enzymology, an acridone synthase ... Synthesis of acridone in Organic Syntheses 19:6; Coll. Vol. 2:15 [3] from o-chlorobenzoic acid and aniline in a Goldberg ... by heating salicylaldehyde with aniline and zinc chloride or by distilling acridone (9-position a carbonyl group) over zinc ... which are readily transformed by the action of alkaline potassium ferricyanide to N-alkyl acridones. Acridine and its ...
*  Furoquinoline alkaloid
"In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum". Antimicrobial Agents and ...
*  Evoxine
Waffo, AF; Coombes, PH; Crouch, NR; Mulholland, DA; El Amin, SM; Smith, PJ (2007). "Acridone and furoquinoline alkaloids from ...
*  Noncovalent solid-phase organic synthesis
In one experimental setup the hydrophobic matrix is RP silica gel (C18) and the anchor is acridone. Acridone is N-alkylated and ...
*  Ruta graveolens
A series of furanoacridones and two acridone alkaloids (arborinine and evoxanthine) have been isolated from R. graveolens. It ...
*  Anthranilate-CoA ligase
This enzyme participates in 3 metabolic pathways: carbazole degradation, benzoate degradation via coa ligation, and acridone ...
*  Lehmstedt-Tanasescu reaction
Lehmsted-Tănăsescu acridone synthesis and Lehmsted-Tanasescu acridone synthesis. In the first step of the reaction mechanism ... The Lehmstedt-Tanasescu reaction is a method in organic chemistry for the organic synthesis of acridone derivatives (3) from a ... leads to the N-nitroso acridone 11 via intermediates 9 en 10. The N-nitroso group is removed by an acid in the final step. The ...
*  Zanthoxylum
... acridones (1-hydroxy-3-methoxy-10-methylacridon-9-one, 1-hydroxy-10-methylacridon-9-one, zanthozolin), and aromatic and ...
*  List of EC numbers (EC 2)
... acridone synthase EC 2.3.1.160: vinorine synthase EC 2.3.1.161: lovastatin nonaketide synthase EC 2.3.1.162: taxadien-5a-ol O- ...
*  T35
... acridone, an antimalarial drug. T35 First post war Douglas flat twin motorcycle later models designated as a 'Mk' series e.g. ...
*  Zanthoxylum gilletii
The lignan sesamin, the N-isobutylamide γ-sanshool, the acridone alkaloids 1-hydroxy-3-methoxy-N-methylacridone, arborinine, ...
Acridone - Wikipedia  Acridone - Wikipedia
Acridone is an organic compound based on the acridine skeleton, with a carbonyl group at the 9 position. It may be synthesized ... Acridone constitutes the scaffold of some synthetic compounds with various pharmacological activities. Most recent derivatives ... 2-chloroacridone is the precursor used to make clomacran (tranquilizer). C. F. H. Allen; G. H. W. McKee (1943). "Acridone". ... "In Vitro and In Vivo Activities of Atalaphillinine and Related Acridone Alkaloids against Rodent Malaria". Antimicrobial Agents ...
more infohttps://en.wikipedia.org/wiki/Acridone
Acridone synthase - Wikipedia  Acridone synthase - Wikipedia
In enzymology, an acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + N- ... Baumert A, Maier W, Groger D, Deutzmann R (1994). "Purification and properties of acridone synthase from cell suspension ... Junghanns KT, Kneusel RE, Groger D, Matern U (1998). "Differential regulation and distribution of acridone synthase in Ruta ... "Native acridone synthases I and II from Ruta graveolens L. form homodimers". FEBS Lett. 448 (1): 135-40. doi:10.1016/S0014-5793 ...
more infohttps://en.wikipedia.org/wiki/Acridone_synthase
Acridone acetic acid (CAS 38609-97-1) Market Research Report 2017  Acridone acetic acid (CAS 38609-97-1) Market Research Report 2017
The report generally describes acridone acetic acid, examines its uses, production methods, patents. Acridone acetic acid ... Acridone acetic acid prices in other regions. 7. ACRIDONE ACETIC ACID END-USE SECTOR 7.1. Acridone acetic acid market by ... 6. ACRIDONE ACETIC ACID MARKET PRICES. 6.1. Acridone acetic acid prices in Europe. 6.2. Acridone acetic acid prices in Asia 6.3 ... 2. ACRIDONE ACETIC ACID APPLICATIONS. 2.1. Acridone acetic acid application spheres, downstream products. 3. ACRIDONE ACETIC ...
more infohttps://marketpublishers.com/report/industry/chemicals_petrochemicals/acridone_acetic_acid_38609-97-1_market_research_report.html
Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae)  Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae)
... Atangana AF, Toze FAA, Langat MK, Happi EN, ... Two new acridone alkaloids, verdoocridone A (1) and B (4), together with fifteen known compounds were isolated from methanol ... 2017). Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS, 19, 191-195. ... Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS, 19, p 191-195. ...
more infohttps://pub.uni-bielefeld.de/publication/2910504
9-Acridone/578-95-0-Kemi-Works  9-Acridone/578-95-0-Kemi-Works
Wuhan Kemi-Works Chemical Co., Ltd. Copyright 2011 Supportby:www.hxchem.net ?̨??? ???? ?? ...
more infohttp://kemiworks.net/kesell.php?id=551
Application of Palladium-Mediated Diarylamine Synthesis and Directed Remote Metalation (DreM) in the Synthesis of Acridones,...  Application of Palladium-Mediated Diarylamine Synthesis and Directed Remote Metalation (DreM) in the Synthesis of Acridones,...
Application of Palladium-Mediated Diarylamine Synthesis and Directed Remote Metalation (DreM) in the Synthesis of Acridones, ...
more infohttp://www.ch.ic.ac.uk/ectoc/echet98/pub/091/index.htm
Hochschulschriften / Anti-protozoal activity of plant-derived flavaglines, acridones and sulfur-containing amides  Hochschulschriften / Anti-protozoal activity of plant-derived flavaglines, acridones and sulfur-containing amides
Anti-protozoal activity of plant-derived flavaglines, acridones and sulfur-containing amides / submitted by Florian Astelbauer ... Acridone Schlagwörter (EN). malaria / Plasmodium falciparum / Leishmania infantum / Trypanosoma cruzi / chemotherapy / plant- ... Anti-protozoal activity of plant-derived flavaglines, acridones and sulfur-containing amides [3.78 mb]. ... Anti-protozoal activity of plant-derived flavaglines, acridones and sulfur-containing amides / submitted by Florian Astelbauer ...
more infohttp://repositorium.meduniwien.ac.at/obvumwhs/content/titleinfo/1714977?lang=de
CSIRO PUBLISHING | Australian Journal of Chemistry  CSIRO PUBLISHING | Australian Journal of Chemistry
CH9750455Acridone studies. XIII. The nature of hexabromoacridone. RH Prager pp. 455-456 ...
more infohttp://www.publish.csiro.au/CH/issue/3583/
Anti-Cancer Agents in Medicinal Chemistry, Volume 15 - Number 8  Anti-Cancer Agents in Medicinal Chemistry, Volume 15 - Number 8
Acridone-based Antitumor Agents: A Mini-review. , 15(8): 1012 - 1025. Wesam S. Alwan, Anand A. Mahajan, Rajesh A. Rane, Anish A ...
more infohttps://benthamscience.com/journals/anti-cancer-agents-in-medicinal-chemistry/volume/15/issue/8/
Fenamic acid - Wikipedia  Fenamic acid - Wikipedia
C. F. H. Allen, G. H. W. McKee (1939). "Acridone". 2: 6. doi:10.15227/orgsyn.019.0006.. .mw-parser-output cite.citation{font- ...
more infohttps://en.wikipedia.org/wiki/Fenamic_acid
NSC 625987 ≥97% (HPLC) | Sigma-Aldrich  NSC 625987 ≥97% (HPLC) | Sigma-Aldrich
... acridone; Linear Formula: C15H13NO2S; find Sigma-N8287 MSDS, related peer-reviewed papers, technical documents, similar ...
more infohttps://www.sigmaaldrich.com/catalog/product/sigma/N8287?lang=en®ion=US
Daye Acetic Chemical, Daye Acetic Chemical Suppliers and Manufacturers at Alibaba.com  Daye Acetic Chemical, Daye Acetic Chemical Suppliers and Manufacturers at Alibaba.com
Tags: 9-oxo-10(9h)-acridineacetic Acid , Acridone Acetic Acid , 38609-97-1 , View larger image ... CAS NO.:38609-97-1)99%9-Oxo-10(9H)-Acridineacetic Acid/Acridone Acetic Acid ...
more infohttps://www.alibaba.com/showroom/daye-acetic-chemical.html
Journal of the Brazilian Chemical Society  Journal of the Brazilian Chemical Society
Antiparasitic Activities of Acridone Alkaloids from Swinglea glutinosa (Bl.) Merr.. Djalma A. P. dos Santos; Paulo C. Vieira; M ... Antiparasitic Activities of Acridone Alkaloids from Swinglea glutinosa (Bl.) Merr.. J. Braz. Chem. Soc. 2009;20(4):644-651. ...
more infohttp://jbcs.sbq.org.br/default.asp?ed=49
Cridanimod - Drugs.com  Cridanimod - Drugs.com
Acridone-N-acetic acid. N-(Carboxymetyl)-9-acridone. Foreign Names. *Cridanimodum (Latin) ...
more infohttps://www.drugs.com/international/cridanimod.html
EC 2.3.1.151-2.3.1.200  EC 2.3.1.151-2.3.1.200
Accepted name: acridone synthase. Reaction: 3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone ... EC 2.3.1.159 acridone synthase. EC 2.3.1.160 vinorine synthase. EC 2.3.1.161 lovastatin nonaketide synthase. EC 2.3.1.162 ... R., Springob, K., Urbanke, C., Ernwein, C., Schröder, G., Schröder, J. and Matern, U. Native acridone synthases I and II from ... 4. Junghanns, K.T., Kneusel, R.E., Groger, D. and Matern, U. Differential regulation and distribution of acridone synthase in ...
more infohttps://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC2/0301d.html
KEGG BRITE: Enzymes - Mycobacterium tuberculosis H37Rv  KEGG BRITE: Enzymes - Mycobacterium tuberculosis H37Rv
2.3.1.159 acridone synthase 2.3.1.160 vinorine synthase 2.3.1.161 lovastatin nonaketide synthase ...
more infohttp://www.genome.jp/kegg-bin/get_htext?mtu01000+Rv2243
US2090511A - Colloidized vat dye 
      - Google Patents  US2090511A - Colloidized vat dye - Google Patents
Anthraquinone Acridones; Example: Indanthrene'Violet RRN, C. I. 1161. 10. Anthraquinone Thioxanthones; Example: Indanthrene ...
more infohttps://patents.google.com/patent/US2090511
Stephens M[au] - PubMed - NCBI  Stephens M[au] - PubMed - NCBI
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.. Dodean RA, Kancharla P, Li Y, Melendez V, ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Stephens+M%5Bau%5D&dispmax=50
Applications filed at May 25 2017 | PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES | Patents.com  Applications filed at May 25 2017 | PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES | Patents.com
ACRIDONE COMPOUNDS. A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity ...
more infohttp://www.patents.com/ap-20170525-p113.html
  • In enzymology, an acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + N-methylanthraniloyl-CoA ⇌ {\displaystyle \rightleftharpoons } 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 Thus, the two substrates of this enzyme are malonyl-CoA and N-methylanthraniloyl-CoA, whereas its 3 products are CoA, 1,3-dihydroxy-N-methylacridone, and CO2. (wikipedia.org)
  • Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L". Z. Naturforsch. (wikipedia.org)
  • Acridone constitutes the scaffold of some synthetic compounds with various pharmacological activities. (wikipedia.org)
  • In conclusion, seven compounds, namely the flavaglines aglafoline and rocaglamide, the acridones 5-hydroxynoracronycine and yukocitrine as well as the sulfur-containing amides methyldambullin, methylgerambullin and sakambullin showed significant anti-protozoal activity. (meduniwien.ac.at)
  • Application of Palladium-Mediated Diarylamine Synthesis and Directed Remote Metalation (DreM) in the Synthesis of Acridones, Anthranilates, Oxindoles and Dibenzo[b,f]azepinones. (ic.ac.uk)
  • Structure-property relationship of donor-acceptor acridones - an optical, electrochemical and computational study. (nih.gov)