Acridones: Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. Many of them are naturally occurring alkaloids.Thioxanthenes: Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.AcridinesRutaceae: A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)Rosales: An order of the ANGIOSPERMS, subclass Rosidae. Its members include some of the most known ornamental and edible plants of temperate zones including roses, apples, cherries, and peaches.Ubiquinone: A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.4-Quinolones: QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.Electron Transport: The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)Electron Transport Complex I: A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.Dianthus: A plant genus of the family CARYOPHYLLACEAE. Members contain dianthins, which are ribosome inactivating proteins.Nucleotide Motifs: Commonly observed BASE SEQUENCE or nucleotide structural components which can be represented by a CONSENSUS SEQUENCE or a SEQUENCE LOGO.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Bacteriology: The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Porphyromonas endodontalis: A species of gram-negative bacteria in the genus PORPHYROMONAS, family Porphyromonadaceae. It is a key pathogen in endodontic infections.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Staphylococcus: A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Mandibular Prosthesis: A prosthetic appliance for the replacement of areas of the mandible missing or defective as a result of deformity, disease, injury, or surgery.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Sarcoma, Synovial: A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)Leiomyosarcoma: A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)Chemical Industry: The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Medicare Assignment: Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.Insurance, Health, Reimbursement: Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988)Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Drug Discovery: The process of finding chemicals for potential therapeutic use.Neglected Diseases: Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. The World Health Organization has designated six tropical infectious diseases as being neglected in industrialized countries that are endemic in many developing countries (HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA).Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Lanthanoid Series Elements: Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).Europium: Europium. An element of the rare earth family of metals. It has the atomic symbol Eu, atomic number 63, and atomic weight 152. Europium is used in the form of its salts as coatings for cathode ray tubes and in the form of its organic derivatives as shift reagents in NMR spectroscopy.Metals, Rare Earth: A group of elements that include SCANDIUM; YTTRIUM; and the LANTHANOID SERIES ELEMENTS. Historically, the rare earth metals got their name from the fact that they were never found in their pure elemental form, but as an oxide. In addition they were very difficult to purify. They are not truly rare and comprise about 25% of the metals in the earth's crust.Luminescent Agents: Compound such as LUMINESCENT PROTEINS that cause or emit light (PHYSICAL LUMINESCENCE).Coumarins: Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.Terbium: Terbium. An element of the rare earth family of metals. It has the atomic symbol Tb, atomic number 65, and atomic weight 158.92.Chelating Agents: Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.

Interactions of antitumor triazoloacridinones with DNA. (1/13)

Triazoloacridinones (TA) are a new group of potent antitumor compounds, from which the most active derivative, C-1305, has been selected for extended preclinical trials. This study investigated the mechanism of TA binding to DNA. Initially, for selected six TA derivatives differing in chemical structures as well as cytotoxicity and antitumor activity, the capability of noncovalent DNA binding was analyzed. We showed that all triazoloacridinones studied stabilized the DNA duplex at a low-concentration buffer but not at a salt concentration corresponding to that in cells. DNA viscometric studies suggested that intercalation to DNA did not play a major role in the mechanism of the cytotoxic action of TA. Studies involving cultured cells revealed that triazoloacridinone C-1305 after previous metabolic activation induced the formation of interstrand crosslinks in DNA of some tumor and fibroblast cells in a dose dependent manner. However, the detection of crosslink formation was possible only when the activity of topoisomerase II in cells was lowered. Furthermore, it was impossible to validate the relevance of the ability to crosslink DNA to biological activity of TA derivatives.  (+info)

Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. (2/13)

A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. A number of acridone derivatives, with side chains bridged three or more carbon atoms apart between the ring nitrogen and terminal nitrogen, demonstrated chloroquine (CQ)-chemosensitizing activity against the MDR strain of P. falciparum (Dd2). Isobologram analysis revealed that selected candidates demonstrated significant synergy with CQ in the CQ-resistant (CQR) parasite Dd2 but only additive (or indifferent) interaction in the CQ-sensitive (CQS) D6. These acridone derivatives also enhanced the sensitivity of other quinoline antimalarials, such as desethylchloroquine (DCQ) and quinine (QN), in Dd2. The patterns of chemosensitizing effects of selected acridones on CQ and QN were similar to those of verapamil against various parasite lines with mutations encoding amino acid 76 of the P. falciparum CQ resistance transporter (PfCRT). Unlike other known chemosensitizers with recognized psychotropic effects (e.g., desipramine, imipramine, and chlorpheniramine), these novel acridone derivatives exhibited no demonstrable effect on the uptake or binding of important biogenic amine neurotransmitters. The combined results indicate that 10-N-substituted acridones present novel pharmacophores for the development of chemosensitizers against P. falciparum.  (+info)

Antitumour properties of acridone alkaloids on a murine lymphoma cell line. (3/13)

The aim of the present study was to investigate the anticancer properties of a set of furanoacridone alkaloids, arborinine and evoxanthine, including the inhibitory effect of P-glycoprotein (Pgp) and the apoptosis-inducing capacity. The tested alkaloids were evaluated for multidrug resistance (MDR)-reversing activity on human Pgp-transfected L5178 mouse lymphoma cells, using the rhodamine-123 (Rh-123) assay. The antiproliferative effects of natural compounds and their interactions with doxorubicin were determined in MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays. Apoptosis-inducing activity was additionally measured by means of dual annexin V and propidium iodide staining. RT-PCR was used to test the expression of Pgp mRNA after acridone treatment. All of the acridones investigated increased the accumulation of Rh-123. Gravacridonetriol and gravacridonediol monomethyl ether increased the antiproliferative effect of doxorubicin on resistant L5178 cells. Treatment with these agents resulted in a decrease in Pgp mRNA levels. Naturally occurring acridone alkaloids exhibit a beneficial combination of anticancer effects and, accordingly, the acridone skeleton can be considered useful in the design of novel antiproliferative agents.  (+info)

A new acridone alkaloid from Micromelum integerrimum. (4/13)

A new acridone alkaloid, 1,3-dihydroxy-4-methoxy-10-methylacridone (1), was isolated from leaves of the plant Micromelum integerrimum, together with two known carbazole alkaloids, glycozolinol (2) and methyl carbazole-3-carboxylate (3). Their structures were elucidated by extensive spectroscopic analysis.  (+info)

Fluorescent properties of acridonyl group in DNA duplex. (5/13)

 (+info)

Isolation of acridone alkaloids and N-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives from Glycosmis parva and their anti-herpes simplex virus activity. (6/13)

Six acridone alkaloids including a new glycosparvarine (1), three limonoids, and four N-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives including two new species, (+)-S-deoxydihydroglyparvin (10) and (+)-S-deoxytetrahydroglyparvin (11), were isolated from the branches and the leaves of Glycosmis parva CRAIB collected in the east of Thailand. Antiviral activity evaluation of isolates against herpes simplex virus (HSV) type 1 and 2 disclosed that two acridone alkaloids, glycosparvarine (1) and glycofolinine (4), showed moderate inhibitory activities with 50% effective concentration (EC50) of 348 microM and 151 microM, respectively; as well, (+)-S-deoxydihydroglyparvin (10) exhibited anti-HSV activity at the lower concentration.  (+info)

Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis. (7/13)

Acridine derivatives constitute a class of compounds that are being intensively studied as potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; however, their clinical application is limited or even excluded because of side effects. Numerous synthetic methods are focused on the preparation of target acridine skeletons or modifications of naturally occurring compounds, such as acridone alkaloids, that exhibit promising anticancer activities. They have been examined in vitro and in vivo to test their importance for cancer treatment and to establish the mechanism of action at both the molecular and cellular level, which is necessary for the optimization of their properties so that they are suitable in chemotherapy. In this article, we review natural and synthetic acridine/acridone analogs, their application as anticancer drugs and methods for their preparation.  (+info)

Synthesis of o-(dimethylamino)aryl ketones and acridones by the reaction of 1,1-dialkylhydrazones and arynes. (8/13)

 (+info)

Application of Palladium-Mediated Diarylamine Synthesis and Directed Remote Metalation (DreM) in the Synthesis of Acridones, Anthranilates, Oxindoles and Dibenzo[b,f]azepinones. ...
Walter Oettmeier, Klaus Masson, Michael Soll, Ellen Reil; Acridones and quinolones as inhibitors of ubiquinone functions in the mitochondrial respiratory chain. Biochem Soc Trans 1 February 1994; 22 (1): 213-216. doi: https://doi.org/10.1042/bst0220213. Download citation file:. ...
Get an in-depth review and ask questions about Nucleophilic aromatic substitution (8). See what people are saying about Nucleophilic aromatic substitution (8).
View Notes - Lecture #25 (Chapter 21) from CHEM 325BL at USC. Phenols and Aryl Halides Nucleophilic Aromatic Substitution Phenols Phenols have the hydroxyl group attached to a benzene ring. The name
The most active compounds tested of substance regards to Staphylococcus aureus were ODI-90 (2,5-difluoro-9-oxo-N-pyridin-4-yl-9,10-dihydroacridine-4-carboxamide) with a minimum inhibitory concentration 0.0041±0.00005 mg/cm3 and the diameter of growth inhibition zone 24.1±0,31mm. Compounds ODI-76, ODI-77, ODI-80, ODI-85 had the minimum inhibitory concentration 0.041 mg/cm3 and the diameter of growth inhibition zone from 20.8±0.34 mm to 21.2±0.4 mm. The compounds ODI-64, ODI-65, ODI-68, ODI-71, ODI-72, ODI-73, ODI-84, ODI-88, ODI-89 which differ by their nature and position of the radicals demonstrated low level of antibacterial activity with a minimal inhibitor concentration. The diameter of the zones of growth inhibition for these compounds was from 8.2±0.4 mm to 14.0±0.36 mm. ...
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The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro- pyridine-4-carboxylate 2.
The report generally describes acridone acetic acid, examines its uses, production methods, patents. Acridone acetic acid market situation is overviewed;
View Notes - Chapter_21 from CHE 321 at SUNY Stony Brook. P1: PCX JWDD052-21 JWDD052-Solomons-v3 Printer: Hamilton May 31, 2007 14:58 21 PHENOLS AND ARYL HALIDES: NUCLEOPHILIC AROMATIC
L-DOPA and manganese both induce oxidative stress-mediated apoptosis in catecholaminergic PC12 cells. In this study, exposure of PC12 cells to 0.2 mM MnCl2 or 10-20 μM L-DOPA neither affected cell viability, determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, nor induced apoptosis, tested by flow cytometry, fluorescence microscopy, and the TUNEL technique. L-DOPA (50 μM) induced decreases in both cell viability and apoptosis. When 0.2 mM MnCl2 was associated with 10, 20, or 50 μM L-DOPA, a concentration-dependent decrease in cell viability was observed. Apoptotic cell death also occurred. In addition, manganese inhibited L-DOPA effects on dopamine (DA) metabolism (i.e., increases in DA and its acidic metabolite levels in both cell lysate and incubation medium). The antioxidant N-acetyl-L-cysteine significantly inhibited decreases in cell viability, apoptosis, and changes in DA metabolism induced by the manganese association with L-DOPA. An increase in ...
The breadth of clinically relevant β-lactamase enzymes in a wide range of Enterobacteriaceae species continues to contribute to a growing global clinical challenge, where even drugs of last resort such as the carbapenems are no longer predictably reliable. S-649266 is a novel siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. The addition of the catechol moiety enables the active transport of S-649266 into bacterial cells via iron transport systems. This molecular technique of harnessing the cells own essential survival mechanisms to increase the penetration of the antimicrobial agent has been described as a Trojan horse approach (14). Since the iron transporters are strongly regulated by the surrounding iron concentrations (24), the culture medium for the MIC determination of S-649266 was supplemented with an iron chelator (human apo-transferrin) to mimic the limited free iron condition present in human biological fluids (21).. In the first ...
The title complex, (I), was obtained in an extension of the work on the synthesis of polycyclic heteroaromatic systems in the double nucleophilic aromatic substitution reaction using o-dichlorobenzene FeCp and related complexes (Sutherland et al., 1982, 1988), followed by modification of the heterocycle structure by oxidation (see Lee et al., 1986, and earlier work by the same authors). This study continues our observations of changes that result in the structure of tricyclic heterocycles containing O and/or S atoms in the central ring of the system upon FeCp complexation and the introduction of substituents into a heterocycle structure. The free heterocycle, phenoxathiin 10,10-dioxide, (II), was obtained in an oxidation of phenoxathiin with hydrogen peroxide in glacial acetic acid solution, as described by Gilman & Esmay (1952).. The unit cell of (I) contains four cationic molecules of the (phenoxathiin 10,10-dioxide) FeCp complex along with four hexafluoridophosphate counteranions. The FeCp ...
The ionic bond is much weaker than a covalent bond. A quaternary ammonium or a nitro onlinne can be substituted by lSF with a nucleophilic aromatic substitution reaction 9,10.
Page 1 of 3 - Trojan Horse Injector .EL - posted in Virus, Trojan, Spyware, and Malware Removal Logs: Hi. I have two Trojan Horse Injectors .EL one is from \\?\globalroot\systemroot\system32\MSIVXkmpmevdyuriesdiuhtijmearsjxfplwb.dll AVG 8.5 Free Edition says it has moved it to the virus vault but when I rescan it AVG finds it back again in the same area. The other Trojan Horse Injector .EL is from: C:\WINDOWS\system32\svchost.exe...
Drugs and Chemicals. All IAs and triazoloacridinones (TAs) were synthesized in the Department of Pharmaceutical Technology and Biochemistry by Drs. M. Cholody, B. Horowska, and M. Konieczny. Compounds were dissolved in 0.2% lactic acid and stored at -24°C until use. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and tetramethylrosamine were obtained from Sigma Chemical Co. (St. Louis, MO). Fumitremorgin C (FTC) and pheophorbide (PhA) were kindly provided by Dr. S. E. Bates (National Cancer Institute, Bethesda, MD). G-418 hydrochloride was purchased from Calbiochem-Novabiochem (San Diego, CA).. Tissue Culture. Human non-small-cell lung cancer A549 cells and T-cell leukemia CCRF-CEM cells were grown under monolayer conditions or up to a maximal density of 106 cells/ml (for CCRF-CEM cells) in RPMI 1640 medium (Invitrogen, Carlsbad, CA) supplemented with 10% fetal calf serum, 2 mM glutamine, 100 μg/ml penicillin, and 100 μg/ml streptomycin (Biological Industries, Beth-Haemek, ...
Infected with Trojan horse Patched_c.LZI, - posted in Virus, Spyware, Malware Removal: Help Same problem as someone else.I keep getting a popup about the trojan horse patched_c.LZI. It says it is in c:\windows\system32\system.exe The process id from AVG says 6108. Sadly I dont know what that means. It continually popped up during the OTL scan. AVG detects it, but since its a critical/system file, I cant do anything with it. It appears to be getting worse...
A Trojan Horse virus disguises itself as something useful, but is designed to cause harm. Learn what a Trojan is and how to remove it with a Trojan virus remover.
Invite this striking mold into your collection and watch it sneak into your favorites. (We promise there are no Greek soldiers hiding inside.) Our Trojan Horse Soap Mold is an intricately detailed, classic cameo horse head, designed to represent the power and grandeur of the ancient equine.
The United States Computer Emergency Readiness Team (CERT) on 12 Aug released a paper of Recovering from a Trojan Horse or Virus which provides basic...
A tool is a tool. As every tool it can be use for good or evil. , ,The purpose of the creator is irrelevant in the real world. , , Not so. When one is reverse-engineering a virus or Trojan horse, , for example, it helps a great deal to know what the creator , intended. , , And the GPL is, in many ways, a Trojan horse. (Its viral, too, , but thats another issue.) , , Programmers see the rhetoric at the top claiming that the license , will promote freedom, and place it upon their code -- whereupon , its terms and conditions promote Stallmans agenda instead. , , If users are fully informed about what a Trojan horse REALLY does, , they may think twice about running it. Obviously everybody should be carefully before using a tool and study and understand for yourself what it really does an not rely on what other people say about it. But that doesnt mean that the tool inherits any evil purpose that the creator of it had in the process of creation. Sure there are trojan horses in the world ...
CHICAGO --- In an entirely new approach to treating asthma and allergies, a biodegradable nanoparticle acts like a Trojan horse, hiding an allergen in a
... . . This is a quick overview that I just found. From attrition.org. When people talk about virii it is common for people to treat the virus, the trojan horse, the logic bomb, etc. as if they were one and the same. Now, personally, I find the idea insulting and I am sure that many virus writers would feel the same way. Time and time again, I have seen the worthy name of VIRUS heaped upon the ranks of such undeserving pranks as the common TROJAN horse.
... . . This is a quick overview that I just found. From attrition.org. When people talk about virii it is common for people to treat the virus, the trojan horse, the logic bomb, etc. as if they were one and the same. Now, personally, I find the idea insulting and I am sure that many virus writers would feel the same way. Time and time again, I have seen the worthy name of VIRUS heaped upon the ranks of such undeserving pranks as the common TROJAN horse.
An experimental Trojan-horse cancer therapy has completely eliminated prostate cancer in experiments on mice, according to UK researchers. | this curious life
How do you get rid of it? Ive did everything they said to do on Norton Antivirus web site but cant get rid of it... I think Norton sucks!
... it was written I should be loyal to the nightmare of my choice. ~Joseph Conrad, The Heart of Darkness Read Part 1, Part 2 and Part 3 and Part 4 and Part 5. By Adriana Gamondes Loyal to the...
The recent updates to the regulations governing FDI in e-commerce will disrupt the existing structures created by some marketplaces
Picking the right virus candidate for gene therapy Viruses often get bad press. Likened to Trojan horses they are often associated with disease. But, i t is precisely because of their infectious nature that they can potentially be used as gene vectors - which are vehicles loaded with good copies of malfunctioning genes - and delivered to cells. ...
BACKGROUND Natural products are well recognized as sources of drugs in several human ailments. In the present work, we carried out a preliminary screening of six natural compounds, xanthone V(1) (1); 2-acetylfuro-1,4-naphthoquinone (2); physcion (3); bisvismiaquinone (4); vismiaquinone (5); 1,8-dihydroxy-3-geranyloxy-6-methylanthraquinone (6) against MiaPaCa-2 pancreatic and CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000. Compounds 1 and 2 were then tested in several other cancer cells and their possible mode of action were investigated. METHODOLOGY/FINDINGS The tested compounds were previously isolated from the Cameroonian medicinal plants Vismia laurentii (1, 3, 4, 5 and 6) and Newbouldia laevis (2). The preliminary cytotoxicity results allowed the selection of xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, which were then tested on a panel of cancer cell lines. The study was also extended to the analysis of cell cycle distribution, apoptosis induction, caspase 3/7
Carbon Compounds and Chemical Bonds. Representative Carbon Compounds. Alkanes and Cycloalkanes: Conformational Analysis. Stereochemistry: Chiral Molecules. Ionic Reactions--Nucleophilic Substitution and Elimination Reactions of Alkyl Halides. Alkenes and Alkynes 1: Properties and Synthesis. Alkenes and Alkynes 2: Addition Reactions of Carbon-Carbon Multiple Bonds. Alcohols and Ethers. Free Radical Reactions. Conjugated Unsaturated Systems. Aromatic Compounds 1: The Phenomenon of Aromaticity. Aromatic Compounds 2: Electrophilic Aromatic Substitution. Spectroscopic Methods of Structure Determination. Phenols and Aryl Halides: Nucleophilic Aromatic Substitution. Organic Oxidation and Reduction Reactions: Organometallic Compounds. Aldehydes and Ketones 1: Nucleophilic Additions to the Carbonyl Group. Aldehydes and Ketones 2: Reactions at the alpha; Carbon--Aldol Reactions. Carboxylic Acids and Their Derivatives: Nucleophilic Substitution at Acyl Carbon. Amines. Synthesis and Reactions of ...
We report herein a photocatalytic arene lactonization via carboxylic radical aromatic substitution. This procedure is characterized by its ability to cleave inert C-X bonds (X = H, F, Cl, Br, O, S) under mild and oxidant-free conditions, thus furnishing a general and operationally simple synthetic protocol f
A team of researchers have recently brought a "Trojan horse" antibody strategy to life that preliminary results have shown potential for combating a whole scope of filoviruses. The idea in this therapeutic method is to ultimately attack the cleaved glycoprotein in the lysosome and/or the NPC1 receptor in the lysosomal membrane to block the entry of viral genetic material into the cell, by bypassing the obvious obstacle that the lysosome is a closed off compartment within the cell. The "Trojan horse" title to this therapy describes how the researchers are utilizing the virus itself to deliver the aforementioned antibodies to the lysosome. This is done by coupling the cleaved GP or NPC1 targeting antibody to an antibody targeting a "binding site" (epitope) broadly conserved across filoviruses in the uncleaved version of the glycoprotein. Using a well-known dual variable domain strategy, DVD-Ig, this coupling of antibodies can be achieved (A.Z. Wec et al., 2016). In a simple sense, this "Trojan ...
N-[4-(2,3-dihydro-1H-indol-1-ylsulfonyl)phenyl]propanamide | C17H18N2O3S | CID 788728 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule n-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide (C19H18N2O4S) from the PQR.
Structure, properties, spectra, suppliers and links for: N-(1-Cycloheptyl-3-piperidinyl)-3-(5-methyl-1H-pyrazol-1-yl)propanamide.
Interactive 3D animations of nitration of benzene - reaction mechanisms for students studying University courses and advanced school chemistry
Cannot get rid of Trojan Horse & Adware Generic5.ARIH and it even blocks security tools? This manual removal guide tell you more & shows how to delete it
... Written by Hilary White 7/31/17 With the breaking of the news into the English language media-sphere the other day, some thoughts converged, into the form of a question: Why would anyone expect Emma
A moderate sized shrub grows up to 1 meter in height. Leaves imparipinnately compound, alternate, gland doted and entire, flowers small, white and seen axillary panicles; fruits pulpy, globose rose berries containing globose seeds ...
Do you find that your PC is acting weirdly lately with frequent message popping up? direct3d.exe might be the culprit here. PC is a complicated machine and with so many different files, settings and procedures to monitor, it is hard to identify just what is slowing you down not to mention implementing the correct technical changes to recover the loss in performance. Firstly, its very important to identify the error that is causing the slow down and lacklustre performance.. Recommendation for Would it be direct3d.exe or other hidden PC errors that is playing prank? Find out here with the FREE system scan. From our experience, direct3d.exe is most likely a virus or trojan. It is highly recommended that you run a FREE system scan to automatically optimize your registry, memory CPU and your PC settings. Damage to your computers registry could be compromising your PCs performance and causing system breakout and crashes. Dont risk it! We recommend that you run this FREE system scan to identify ...
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The synthesis of indaphyrins, novel meso-tetraarylsecochlorin-derived chromophores incorporating o-phenyl-to-beta-linkages, is described. Oxidative diol cleavage of meso-tetraaryl-2,3-dihydroxy-2,3-chlorins results in the formation of a secochlorin bisaldehyde. Depending on the reaction conditions during the ring cleavage reaction, one or two of the aldehyde groups react with the adjacent o-phenyl positions, leading to an intramolecular electrophilic aromatic substitution of the o-phenyl proton, and the establishment of a direct o-phenyl-to-beta-linkage. The initially formed carbinol is spontaneously oxidized to the corresponding ketone. This modification forces the aryl groups into co-planarity with the macrocycle, allowing for interactions between the pi-electrons of the aryl groups, the ketone linkage, and those of the chromophore, resulting in a significant electronic modulation of the porphyrinic pi-system. The UV-vis spectroscopic properties of the free base, CuII, NiII, and ZnII indaphyrins are
Researchers have been engineering nanoparticles to ferry toxic medicines into tumor cells before they release their cargo. After many years of studies with cell cultures and animals, nearly a dozen nanoparticle-based drugs are in clinical trials, most of which aim at treating or diagnosing cancer. Many other compounds are progressing through preclinical studies and are nearing human trials. Although it will require several more years of testing to determine whether the compounds are safe and effective, researchers are optimistic that the results will be positive. That would be welcome news in the fight against cancer. ...
Nervals Lobster writes Nest (based in Palo Alto, and headed by former Apple executive Tony Fadell) is out to reinvent the ugly, blocky devices—starting with the thermostat—that we bolt to our walls and ceilings out of necessity. Its new Nest Protect, looks more like something for strea...
Help! seem to have the same problem as soccer_chika, when I scan with AVG. I Followed the first part of what was suggested previously by blind dragon....
German researchers on Wednesday presented a Trojan horse method of attacking cancer, sneaking virus impersonators into the human body to unleash an anti-tu
On Fri, 30 Jan 2004, Smart,Dan wrote: , Couldnt the poisoned list be simplified to the following: {snip sample} Sure. It is possible, however, that someone would not want to poison *.exe and would like a starter list of old, obsolete viruses and trojan horses... :) (Anybody still buy that excuse?) At the moment its just ugly. Having the extra entries isnt a performance hit. , Also, shouldnt the following be added? , , *.cpl Can control panel applets be directly executed? , *.jse , *.sct Do you have a reference for what JSE and SCT files are? , The .ex, .pi, .sc and .zi were added by me when a virus was adding , attachment but dropped the last letter of the attachment name. , One of those in August like SoBig, Blaster, etc. Mrf. I dont know about that. How many did you see? And (apart from the .ZIP) did the Windows Executable Magic test trap them? -- John Hardin KA7OHZ ICQ#15735746 http://www.impsec.org/~jhardin/ jhardin at impsec.org pgpk -a jhardin at impsec.org key: 0xB8732E79 - 2D8C 34F4 ...
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C. F. H. Allen, G. H. W. McKee (1939). "Acridone". 2: 6. doi:10.15227/orgsyn.019.0006.. .mw-parser-output cite.citation{font- ...
An example of a Goldberg reaction is the synthesis of fenamic acid, an intermediate of acridone via the Goldberg reaction: An ... 2003 WO02/085838 Link[permanent dead link] C. F. H. Allen and G. H. W. McKee (1943). "Acridone". Organic Syntheses. ; ...
It may be prepared from acridone. There's also a route from toluene:. ...
This enzyme participates in acridone alkaloid biosynthesis. Eilert U; Wolters B (1989). "Elicitor induction of S-adenosyl-L- ...
Another classic method for the synthesis of acridones is the Lehmstedt-Tanasescu reaction. In enzymology, an acridone synthase ... Synthesis of acridone in Organic Syntheses 19:6; Coll. Vol. 2:15 [3] from o-chlorobenzoic acid and aniline in a Goldberg ... by heating salicylaldehyde with aniline and zinc chloride or by distilling acridone (9-position a carbonyl group) over zinc ... which are readily transformed by the action of alkaline potassium ferricyanide to N-alkyl acridones. Acridine and its ...
"In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum". Antimicrobial Agents and ...
Waffo, AF; Coombes, PH; Crouch, NR; Mulholland, DA; El Amin, SM; Smith, PJ (2007). "Acridone and furoquinoline alkaloids from ...
In one experimental setup the hydrophobic matrix is RP silica gel (C18) and the anchor is acridone. Acridone is N-alkylated and ...
A series of furanoacridones and two acridone alkaloids (arborinine and evoxanthine) have been isolated from R. graveolens. It ...
This enzyme participates in 3 metabolic pathways: carbazole degradation, benzoate degradation via coa ligation, and acridone ...
Lehmsted-Tănăsescu acridone synthesis and Lehmsted-Tanasescu acridone synthesis. In the first step of the reaction mechanism ... The Lehmstedt-Tanasescu reaction is a method in organic chemistry for the organic synthesis of acridone derivatives (3) from a ... leads to the N-nitroso acridone 11 via intermediates 9 en 10. The N-nitroso group is removed by an acid in the final step. The ...
... acridones (1-hydroxy-3-methoxy-10-methylacridon-9-one, 1-hydroxy-10-methylacridon-9-one, zanthozolin), and aromatic and ...
... acridone synthase EC 2.3.1.160: vinorine synthase EC 2.3.1.161: lovastatin nonaketide synthase EC 2.3.1.162: taxadien-5a-ol O- ...
... acridone, an antimalarial drug. T35 First post war Douglas flat twin motorcycle later models designated as a 'Mk' series e.g. ...
The lignan sesamin, the N-isobutylamide γ-sanshool, the acridone alkaloids 1-hydroxy-3-methoxy-N-methylacridone, arborinine, ...
... is an organic compound based on the acridine skeleton, with a carbonyl group at the 9 position. It may be synthesized ... Acridone constitutes the scaffold of some synthetic compounds with various pharmacological activities. Most recent derivatives ... 2-chloroacridone is the precursor used to make clomacran (tranquilizer). C. F. H. Allen; G. H. W. McKee (1943). "Acridone". ... "In Vitro and In Vivo Activities of Atalaphillinine and Related Acridone Alkaloids against Rodent Malaria". Antimicrobial Agents ...
In enzymology, an acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + N- ... Baumert A, Maier W, Groger D, Deutzmann R (1994). "Purification and properties of acridone synthase from cell suspension ... Junghanns KT, Kneusel RE, Groger D, Matern U (1998). "Differential regulation and distribution of acridone synthase in Ruta ... "Native acridone synthases I and II from Ruta graveolens L. form homodimers". FEBS Lett. 448 (1): 135-40. doi:10.1016/S0014-5793 ...
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Acridone is an organic compound based on the acridine skeleton, with a carbonyl group at the 9 position. It may be synthesized ... Acridone constitutes the scaffold of some synthetic compounds with various pharmacological activities. Most recent derivatives ... 2-chloroacridone is the precursor used to make clomacran (tranquilizer). C. F. H. Allen; G. H. W. McKee (1943). "Acridone". ... "In Vitro and In Vivo Activities of Atalaphillinine and Related Acridone Alkaloids against Rodent Malaria". Antimicrobial Agents ...
In enzymology, an acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + N- ... Baumert A, Maier W, Groger D, Deutzmann R (1994). "Purification and properties of acridone synthase from cell suspension ... Junghanns KT, Kneusel RE, Groger D, Matern U (1998). "Differential regulation and distribution of acridone synthase in Ruta ... "Native acridone synthases I and II from Ruta graveolens L. form homodimers". FEBS Lett. 448 (1): 135-40. doi:10.1016/S0014-5793 ...
The report generally describes acridone acetic acid, examines its uses, production methods, patents. Acridone acetic acid ... Acridone acetic acid prices in other regions. 7. ACRIDONE ACETIC ACID END-USE SECTOR 7.1. Acridone acetic acid market by ... 6. ACRIDONE ACETIC ACID MARKET PRICES. 6.1. Acridone acetic acid prices in Europe. 6.2. Acridone acetic acid prices in Asia 6.3 ... 2. ACRIDONE ACETIC ACID APPLICATIONS. 2.1. Acridone acetic acid application spheres, downstream products. 3. ACRIDONE ACETIC ...
Acridones and quinolones as inhibitors of ubiquinone functions in the mitochondrial respiratory chain Walter Oettmeier; Walter ... Walter Oettmeier, Klaus Masson, Michael Soll, Ellen Reil; Acridones and quinolones as inhibitors of ubiquinone functions in the ...
The goal of this study was to assess efficacy of acridone acetic acid, sodium salt (Na-AAA), … ... Acridone Acetic Acid, Sodium Salt, as an Agent to Stop Vitiligo Progression: A Pilot Study Dermatol Ther. Jul-Aug 2014;27(4): ... The goal of this study was to assess efficacy of acridone acetic acid, sodium salt (Na-AAA), an immunomodulating compound with ... In conclusion, acridone acetic acid, sodium salt, emerges as an efficient option for stopping vitiligo progression. ...
... Atangana AF, Toze FAA, Langat MK, Happi EN, ... Two new acridone alkaloids, verdoocridone A (1) and B (4), together with fifteen known compounds were isolated from methanol ... 2017). Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS, 19, 191-195. ... Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS, 19, p 191-195. ...
We have discovered a novel antimalarial acridone chemotype with dual-stage activity against both liver-stage and blood-stage ... This study offers the first account of liver-stage antimalarial activity in an acridone chemotype. Details of the design, ... Several lead compounds generated from structural optimization of a large library of novel acridones exhibit efficacy in the ... We have discovered a novel antimalarial acridone chemotype with dual-stage activity against both liver-stage and blood-stage ...
Application of Palladium-Mediated Diarylamine Synthesis and Directed Remote Metalation (DreM) in the Synthesis of Acridones, ...
Wuhan Kemi-Works Chemical Co., Ltd. Copyright 2011 Supportby:www.hxchem.net ?̨??? ???? ?? ...
Anti-protozoal activity of plant-derived flavaglines, acridones and sulfur-containing amides / submitted by Florian Astelbauer ... Acridone Schlagwörter (EN). malaria / Plasmodium falciparum / Leishmania infantum / Trypanosoma cruzi / chemotherapy / plant- ... Anti-protozoal activity of plant-derived flavaglines, acridones and sulfur-containing amides [3.78 mb]. ... Anti-protozoal activity of plant-derived flavaglines, acridones and sulfur-containing amides / submitted by Florian Astelbauer ...
CH9750455Acridone studies. XIII. The nature of hexabromoacridone. RH Prager pp. 455-456 ...
INVESTIGATION OF THE ANTIBACTERIAL ACTION OF MODIFIED HETEROCYCLIC COMPOUNDS OF SUBSTITUTED ACRIDONES AGAINST STAPHYLOCOCCUS ... In this research we used the substituted acridones class compounds. We chose fourteen the most perspective substances with some ... As the result of investigation the minimal inhibitory concentration and growth of inhibition zones of substituted acridones ... The results of the study of antibacterial activity and determination of minimum inhibitory concentration substituted acridones ...
C. F. H. Allen, G. H. W. McKee (1939). "Acridone". 2: 6. doi:10.15227/orgsyn.019.0006.. .mw-parser-output cite.citation{font- ...
Amino acid or peptide conjugates of acridine/acridone and quinoline/quinolone-containing drugs. A critical examination of their ...
Tags: 9-oxo-10(9h)-acridineacetic Acid , Acridone Acetic Acid , 38609-97-1 , View larger image ... CAS NO.:38609-97-1)99%9-Oxo-10(9H)-Acridineacetic Acid/Acridone Acetic Acid ...
Acridone-based Antitumor Agents: A Mini-review. , 15(8): 1012 - 1025. Wesam S. Alwan, Anand A. Mahajan, Rajesh A. Rane, Anish A ...
... acridone; Linear Formula: C15H13NO2S; find Sigma-N8287 MSDS, related peer-reviewed papers, technical documents, similar ...
Acridone-N-acetic acid. N-(Carboxymetyl)-9-acridone. Foreign Names. *Cridanimodum (Latin) ...
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.. Dodean RA, Kancharla P, Li Y, Melendez V, ...
Structure-property relationship of donor-acceptor acridones - an optical, electrochemical and computational study. ...
Acridone derivatives as labels for fluorescence detection of target materials. US20080146460 *. 19 Jul 2007. 19 Jun 2008. ... Acridone derivatives as labels for fluorescence detection of target materials. US8067536. 22 Mar 2010. 29 Nov 2011. Life ...
Michael, J.P. Quinoline, quinazoline and acridone alkaloids. Nat. Prod. Rep. 2008, 25, 166-187. [Google Scholar] [CrossRef] [ ...
2.3.1.159 acridone synthase 2.3.1.160 vinorine synthase 2.3.1.161 lovastatin nonaketide synthase ...
Accepted name: acridone synthase. Reaction: 3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone ... EC 2.3.1.159 acridone synthase. EC 2.3.1.160 vinorine synthase. EC 2.3.1.161 lovastatin nonaketide synthase. EC 2.3.1.162 ... R., Springob, K., Urbanke, C., Ernwein, C., Schröder, G., Schröder, J. and Matern, U. Native acridone synthases I and II from ... 4. Junghanns, K.T., Kneusel, R.E., Groger, D. and Matern, U. Differential regulation and distribution of acridone synthase in ...
Antiparasitic Activities of Acridone Alkaloids from Swinglea glutinosa (Bl.) Merr.. Djalma A. P. dos Santos; Paulo C. Vieira; M ... Antiparasitic Activities of Acridone Alkaloids from Swinglea glutinosa (Bl.) Merr.. J. Braz. Chem. Soc. 2009;20(4):644-651. ...
  • In enzymology, an acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction 3 malonyl-CoA + N-methylanthraniloyl-CoA ⇌ {\displaystyle \rightleftharpoons } 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 Thus, the two substrates of this enzyme are malonyl-CoA and N-methylanthraniloyl-CoA, whereas its 3 products are CoA, 1,3-dihydroxy-N-methylacridone, and CO2. (wikipedia.org)
  • Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L". Z. Naturforsch. (wikipedia.org)
  • They are highly homologous to each other, and are likely to fall into a family of PKSs along with acridone synthase and bibenzyl synthase. (nii.ac.jp)
  • Amino acid or peptide conjugates of acridine/acridone and quinoline/quinolone-containing drugs. (nature.com)
  • Other drugs selected for their activity against the exoerythrocytic stages of malaria and which proved to be ineffective in toxoplasmosis included a sulfanilanilide (SN 187), a metanilamide (SN 11,437), a naphthoquinone (SN 8557), an 8-amino-quinoline (SN 13,276), a biguanide (SN 12,837), and an acridone (DR 15,575). (ajtmh.org)
  • Recent publications have identified a number of novel quinoline and acridone compounds that appear to either reverse or evade the chloroquine-resistance mechanism in vitro , and which are considered to be promising leads for the development of new antimalarials (Burgess et al . (edu.au)
  • A methanolic extract of roots of Carissa congesta yielded a des-N-methylnoracronycine, an acridone alkaloid, carissone, carindone, lupeol besides stigmasterol, ursolic acid and its methyl ester. (stuartxchange.com)
  • Discovery and Structural Optimization of Acridones as Broad-Spectrum A" by Rozalia A. Dodean, Papireddy Kancharla et al. (pdx.edu)
  • Structure-property relationship of donor-acceptor acridones - an optical, electrochemical and computational study. (nih.gov)
  • In the present study, we aimed to elucidate the chemosensitization potential of acridones by employing various molecular modelling techniques. (readbyqxmd.com)