Dictionaries, MedicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.AcridinesTopoisomerase Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASES.Tetrahydroisoquinolines: A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.Zinc Compounds: Inorganic compounds that contain zinc as an integral part of the molecule.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)Zinc: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.Staining and Labeling: The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.Citrus sinensis: A plant species of the genus CITRUS, family RUTACEAE that provides the familiar orange fruit which is also a source of orange oil.Aminoacridines: Acridines which are substituted in any position by one or more amino groups or substituted amino groups.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.District of Columbia: A federal area located between Maryland and Virginia on the Potomac river; it is coextensive with Washington, D.C., which is the capital of the United States.Minicomputers: Small computers that lack the speed, memory capacity, and instructional capability of the full-size computer but usually retain its programmable flexibility. They are larger, faster, and more flexible, powerful, and expensive than microcomputers.Guyana: A republic in the north of South America, east of VENEZUELA and west of SURINAME. Its capital is Georgetown.Myanmar: A republic of southeast Asia, northwest of Thailand, long familiar as Burma. Its capital is Yangon, formerly Rangoon. Inhabited by people of Mongolian stock and probably of Tibetan origin, by the 3d century A.D. it was settled by Hindus. The modern Burmese state was founded in the 18th century but was in conflict with the British during the 19th century. Made a crown colony of Great Britain in 1937, it was granted independence in 1947. In 1989 it became Myanmar. The name comes from myanma, meaning the strong, as applied to the Burmese people themselves. (From Webster's New Geographical Dictionary, 1988, p192 & Room, Brewer's Dictionary of Names, 1992, p367)Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Salts: Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Dictionaries, ChemicalZona Pellucida: A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.Hyaluronic Acid: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.Sperm-Ovum Interactions: Interactive processes between the oocyte (OVUM) and the sperm (SPERMATOZOA) including sperm adhesion, ACROSOME REACTION, sperm penetration of the ZONA PELLUCIDA, and events leading to FERTILIZATION.Chromatin: The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.Bentonite: A colloidal, hydrated aluminum silicate that swells 12 times its dry size when added to water.Aluminum Silicates: Any of the numerous types of clay which contain varying proportions of Al2O3 and SiO2. They are made synthetically by heating aluminum fluoride at 1000-2000 degrees C with silica and water vapor. (From Hawley's Condensed Chemical Dictionary, 11th ed)Adsorption: The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.Photoelectron Spectroscopy: The study of the energy of electrons ejected from matter by the photoelectric effect, i.e., as a direct result of absorption of energy from electromagnetic radiation. As the energies of the electrons are characteristic of a specific element, the measurement of the energy of these electrons is a technique used to determine the chemical composition of surfaces.Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: "high ridge"), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Cesarean Section: Extraction of the FETUS by means of abdominal HYSTEROTOMY.Intercalating Agents: Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.Aminacrine: A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Glass: Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.Fixatives: Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.Microtomy: The technique of using a microtome to cut thin or ultrathin sections of tissues embedded in a supporting substance. The microtome is an instrument that hold a steel, glass or diamond knife in clamps at an angle to the blocks of prepared tissues, which it cuts in sections of equal thickness.Waxes: A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)Formaldehyde: A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)PicratesNitracrine: Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Hematinics: Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.Chemistry, Clinical: The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.Topoisomerase II Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.DNA Topoisomerases, Type II: DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.Ganoderma: A genus of fungi in the family Ganodermataceae, order POLYPORALES, containing a dimitic hyphal system. It causes a white rot, and is a wood decomposer. Ganoderma lucidum (REISHI) is used in traditional Chinese medicine (MEDICINE, CHINESE TRADITIONAL).Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Razoxane: An antimitotic agent with immunosuppressive properties.Cell Line, Tumor: A cell line derived from cultured tumor cells.

Characterization of nuclear structures containing superhelical DNA. (1/786)

Structures resembling nuclei but depleted of protein may be released by gently lysing cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids sediment in gradients containing intercalating agents in a manner characteristic of DNA that is intact, supercoiled and circular. The concentration of salt present during isolation of human nucleoids affects their protein content. When made in I-95 M NaCl they lack histones and most of the proteins characteristic of chromatin; in 1-0 M NaCl they contain variable amounts of histones. The effects of various treatments on nucleoid integrity were investigated.  (+info)

Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. (2/786)

Class I P-glycoproteins (Pgp) confer multidrug resistance in tumors, but the physiologic function of Pgp in normal tissues remains uncertain. In cells derived from tissues that normally express Pgp, recent data suggest a possible role for Pgp in cholesterol trafficking from the plasma membrane to the endoplasmic reticulum. We investigated the esterification of plasma membrane cholesterol under basal conditions and in response to sphingomyelinase treatment in transfected and drug-selected cell lines expressing differing amounts of functional class I Pgp. Compared with parental NIH 3T3 fibroblasts, cells transfected with human multidrug resistance (MDR1) Pgp esterified more cholesterol both without and with sphingomyelinase. Esterification also was greater in drug-selected Dox 6 myeloma cells than parental 8226 cells, which express low and non-immunodetectable amounts of Pgp, respectively. However, no differences in total plasma membrane cholesterol were detected. Transfection of fibroblasts with the multidrug resistance-associated protein (MRP) did not alter esterification, showing that cholesterol trafficking was not generally affected by ATP-binding cassette transporters. Steroidal (progesterone, dehydroepiandrosterone) and non-steroidal antagonists (verapamil, PSC 833, LY335979, and GF120918) were evaluated for effects on both cholesterol trafficking and the net content of 99mTc-Sestamibi, a reporter of drug transport activity mediated by Pgp. In Pgp-expressing cells treated with nonselective and selective inhibitors, both the kinetics and efficacy of inhibition of cholesterol esterification differed from the antagonism of drug transport mediated by Pgp. Thus, although the data show that greater expression of class I Pgp within a given cell type is associated with enhanced esterification of plasma membrane cholesterol in support of a physiologic function for Pgp in facilitating cholesterol trafficking, the molecular mechanism is dissociated from the conventional drug transport activity of Pgp.  (+info)

Serum sErbB1 and epidermal growth factor levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. (3/786)

Epithelial ovarian cancer (EOC) has a high mortality rate, which is due primarily to the fact that early clinical symptoms are vague and nonspecific; hence, this disease often goes undetected and untreated until in its advanced stages. Sensitive and reliable methods for detecting earlier stages of EOC are, therefore, urgently needed. Epidermal growth factor (EGF) is a ligand for EGF receptor (ErbB1); this receptor is the product of the c-erbB1 proto-oncogene. ErbB1 overexpression is common in human ovarian carcinoma-derived cell lines and tumors, in which overexpression is thought to play a critical role in tumor etiology and progression. Furthermore, ErbB1 overexpression is associated with disease recurrence and decreased patient survival. Recently, we have developed an acridinium-linked immunosorbent assay that detects a approximately 110-kDa soluble analogue of ErbB1, ie., sErbB1, in serum samples from healthy men and women (A. T. Baron, et al., J. Immunol. Methods, 219: 23-43, 1998). Here, we demonstrate that serum p110 sErbB1 levels are significantly lower in EOC patients with stage III or IV disease prior to (P < 0.0001) and shortly after (P < 0.0001) cytoreductive staging laparotomy than in healthy women of similar ages, whereas EGF levels are significantly higher than those of age-matched healthy women only in serum samples collected shortly after tumor debulking surgery (P < 0.0001). We observe that the preoperative serum sErbB1 concentration range of advanced stage EOC patients barely overlaps with the serum sErbB1 concentration range of healthy women. In addition, we show that serum sErbB1 and EGF levels changed temporally for some EOC patients who were surgically debulked of tumor and who provided a second serum sample during the course of combination chemotherapy. Finally, we observe a significant positive association between sErbB1 and EGF levels only in serum samples of EOC patients collected prior to cytoreductive surgery (correlation coefficient = 0.61968; P = 0.0027). These data suggest that epithelial ovarian tumors concomitantly affect serum sErbB1 and EGF levels. In conclusion, these data indicate that serum sErbB1 and EGF (postoperative only) levels are significantly different between EOC patients and healthy women and that altered and/or changing serum sErbB1 and EGF levels may provide important diagnostic and/or prognostic information useful for the management of patients with EOC.  (+info)

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918. (4/786)

The acridone carboxamide derivative GG918 (N-{4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-pheny l}-9,10dihydro-5-methoxy-9-oxo-4-acridine carboxamide) is a potent inhibitor of MDR1 P-glycoprotein-mediated multidrug resistance. Direct measurements of ATP-dependent MDR1 P-glycoprotein-mediated transport in plasma membrane vesicles from human and rat hepatocyte canalicular membranes indicated 50% inhibition at GG918 concentrations between 8 nM and 80 nM using N-pentyl-[3H]quinidinium, ['4C]doxorubicin and [3H]daunorubicin as substrates. The inhibition constant K for GG918 was 35 nM in rat hepatocyte canalicular membrane vesicles with [3H]daunorubicin as the substrate. Photoaffinity labelling of canalicular and recombinant rat Mdr1b P-glycoprotein by [3H]azidopine was suppressed by 10 muM and 40 muM GG918. The high selectivity of GG918-induced inhibition was demonstrated in canalicular membrane vesicles and by analysis of the hepatobiliary elimination in rats using [3H]daunorubicin, [3H]taurocholate and [3H]cysteinyl leukotrienes as substrates for three distinct ATP-dependent export pumps. Almost complete inhibition of [3H]daunorubicin transport was observed at GG918 concentrations that did not affect the other hepatocyte canalicular export pumps. The high potency and selectivity of GG918 for the inhibition of human MDR1 and rat Mdr1b P-glycoprotein may serve to interfere with this type of multidrug resistance and provides a tool for studies on the function of these ATP-dependent transport proteins.  (+info)

A method for the deductive and unique determination of the values of three parameters involved in fractional functions applicable to relaxation kinetics. (5/786)

A novel method is proposed to determine deductively and uniquely the values of three parameters, a, b, and c in a fractional function of the form, y=a+bx/(c+x) where x and y are experimentally obtainable variables. This type of equation is frequently encountered in chemistry and biochemistry involving relaxation kinetics. The method of least squares with the Taylor expansion is employed for direct curve fitting of observed data to the fractional function. Approximate values of the parameters, which are always necessary prior to commending the above procedure, can be obtained by the method of rearrangement after canceling the denominator of fractional functions. This procedure is very simple, but very effective for estimating provisional values of the parameters. Deductive and unique determination of the parameters involved in the fractional function shown above can be accomplished for the first time by the combination of these two procedures. This method is extended to include the analysis of relaxation kinetic data such as those of temperature-jump method where the determination of equilibrium concentrations of reactants in addition to the three parameters is also necessary.  (+info)

Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. (6/786)

BACKGROUND: Angiotensin II activates NAD(P)H-dependent oxidases via AT1-receptor stimulation, the most important vascular source of superoxide (O2*-). The AT1 receptor is upregulated in vitro by low-density lipoprotein. The present study was designed to test whether hypercholesterolemia is associated with increased NAD(P)H-dependent vascular O2*- production and whether AT1-receptor blockade may inhibit this oxidase and in parallel improve endothelial dysfunction. METHODS AND RESULTS: Vascular responses were determined by isometric tension studies, and relative rates of vascular O2*- production were determined by use of chemiluminescence with lucigenin, a cypridina luciferin analogue, and electron spin resonance studies. AT1-receptor mRNA was quantified by Northern analysis, and AT1-receptor density was measured by radioligand binding assays. Hypercholesterolemia was associated with impaired endothelium-dependent vasodilation and increased O2*- production in intact vessels. In vessel homogenates, we found a significant activation of NADH-driven O2*- production in both models of hyperlipidemia. Treatment of cholesterol-fed animals with the AT1-receptor antagonist Bay 10-6734 improved endothelial dysfunction, normalized vascular O2*- and NADH-oxidase activity, decreased macrophage infiltration, and reduced early plaque formation. In the setting of hypercholesterolemia, the aortic AT1 receptor mRNA was upregulated to 166+/-11%, accompanied by a comparable increase in AT1-receptor density. CONCLUSIONS: Hypercholesterolemia is associated with AT1-receptor upregulation, endothelial dysfunction, and increased NADH-dependent vascular O2*- production. The improvement of endothelial dysfunction, inhibition of the oxidase, and reduction of early plaque formation by an AT1-receptor antagonist suggests a crucial role of angiotensin II-mediated O2*- production in the early stage of atherosclerosis.  (+info)

Paracrine role of adventitial superoxide anion in mediating spontaneous tone of the isolated rat aorta in angiotensin II-induced hypertension. (7/786)

The relationship between vascular generation of superoxide anion and spontaneous tone observed in the isolated aorta was studied in hypertensive rats infused with angiotensin II. Aortic rings from hypertensive, but not from sham-operated rats, demonstrated oscillatory spontaneous tone that represented 52+/-5.6% of the maximal contraction to KCl. Spontaneous tone was prevented by calcium-free buffer or by blocking calcium influx through L-type calcium channels with nifedipine. The production of superoxide anion measured by lucigenin chemiluminescence was up to 15-fold higher than in sham-operated rat aorta. The adventitial site of production of superoxide anion was suggested by the fact that lucigenin chemiluminescence was 5.5-fold higher from the adventitia than from the intima. This was confirmed histochemically by demonstrating that the adventitia was the site of reduction of nitroblue tetrazolium as well as immunohistochemical staining of NAD(P)H oxidase subunit proteins. A causal link between superoxide anion production by NAD(P)H oxidase and the spontaneous tone is suggested by the fact that superoxide dismutase or the inhibitor of NAD(P)H oxidase, diphenylene iodonium, decreased both superoxide anion production and spontaneous tone. L-NAME or removal of the endothelium from the aorta had no significant effect on superoxide anion levels or spontaneous tone. However, although superoxide dismutase decreased superoxide anion levels in the presence of L-NAME or in endothelium-denuded rings, it no longer inhibited the tone. This suggests that the effect on tone of superoxide anion originating in the adventitia is mediated by inactivating endothelium-derived nitric oxide, which promotes smooth muscle calcium influx and spontaneous tone. The adventitia is not a passive bystander during the development of hypertension, but rather it may have an important role in the regulation of smooth muscle tone.  (+info)

Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation. (8/786)

Lucigenin-amplified chemiluminescence has frequently been used to assess the formation of superoxide in vascular tissues. However, the ability of lucigenin to undergo redox cycling in purified enzyme-substrate mixtures has raised questions concerning the use of lucigenin as an appropriate probe for the measurement of superoxide production. Addition of lucigenin to reaction mixtures of xanthine oxidase plus NADH resulted in increased oxygen consumption, as well as superoxide dismutase-inhibitable reduction of cytochrome c, indicative of enhanced rates of superoxide formation. Additionally, it was revealed that lucigenin stimulated oxidant formation by both cultured bovine aortic endothelial cells and isolated rings from rat aorta. Lucigenin treatment resulted in enhanced hydrogen peroxide release from endothelial cells, whereas exposure to lucigenin resulted in inhibition of endothelium-dependent relaxation in isolated aortic rings that was superoxide dismutase inhibitable. In contrast, the chemiluminescent probe coelenterazine had no significant effect on xanthine oxidase-dependent oxygen consumption, endothelial cell hydrogen peroxide release, or endothelium-dependent relaxation. Study of enzyme and vascular systems indicated that coelenterazine chemiluminescence is a sensitive marker for detecting both superoxide and peroxynitrite.  (+info)

Synonyms for acridine dye in Free Thesaurus. Antonyms for acridine dye. 30 synonyms for dye: colour, stain, tint, shade, tinge, pigment, tincture, colour-wash, colouring, colour, pigment, wash, stain, tint, tinge, colorant, color. What are synonyms for acridine dye?
Export Data And Price Of ETHYL PHENYL , www.eximpulse.com Eximpulse Services is the place where you can find the recent and updated Trade intelligence report of ETHYL PHENYL Export Data. Whole information is based on updated Export shipment data of Indian Customs. All the compilation is done on the basis of All India ports data and has been done on daily basis. This helps you to get all India ETHYL PHENYL Export data. You can find previous two days ETHYL PHENYL Export data on Eximpulse Services. ETHYL PHENYL Export data can be useful in different kind of analysis such as: Export price, Quantity, market scenarios, Price trends, Duty optimization and many more. Some Sample Shipment records for ETHYL PHENYL Export Data of India are mentioned above. Further for Free sample and pricing of detailed reports contact on [email protected] Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have names of Indian companies and Foreign Companies.. ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
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The objective of this study was to characterize the influence of P-gp and Bcrp at the mouse BBB on the nonlinear CNS distribution of elacridar. This compound has been widely used as a P-gp and Bcrp inhibitor, both in vitro and in vivo. However, the brain distribution of elacridar has not been fully characterized. Earlier studies using radiolabeled elacridar and positron emission tomography qualitatively examined the CNS distribution of elacridar-associated radioactivity in wild-type, P-gp knockout, Bcrp knockout, and triple knockout mice (Dorner et al., 2009; Kawamura et al., 2011a,b). The results from those studies indicated that P-gp and Bcrp could play a role in limiting the brain distribution of elacridar. Our previous study (Sane et al., 2012) was the first to quantitatively examine the brain distribution of elacridar in wild-type mice using a specific stability-indicating assay (LC-MS/MS). The current study examined various factors that could influence elacridar brain distribution, ...
Since the properties of small molecules can change upon conjugation to proteins, we investigated the binding of CB[8] to TMV-6 following the confirmation of the TMV-6 conjugate. Since the solutions of TMV-6 at concentrations required for ITC characterization were subject to viscosity and adhesion issues, a fluorescence titration was used instead to determine a dissociation constant. In this case, neither TMV-6 nor CB[8] contain fluorophores, so a competitive binding strategy incorporating a fluorophore was implemented. Acridine-3,6-diamine, or proflavin (PF), is an acridine derivative that is fluorescent as a free molecule in aqueous solutions, but its fluorescence becomes quenched68,69 upon binding inside the cavity of CB[8]. A fluorescence titration of increasing concentrations of TMV-6 (0-20 μM relative to TEMPO) titrated into solutions with a constant concentration of the CB[8]⊃PF (0.2 μM) complex was performed. Upon the addition of increasing concentrations of TMV-6, the observed ...
Lookchem Provide Cas No.118474-59-2 Basic information: Properties,Safety Data,Sds and Other Datebase. We also Provide Trading Suppliers & Manufacture for 118474-59-2 10-{3-[(2-aminoethyl)amino]propyl}-3,6-bis(dimethylamino)acridinium platinum(2+) chloride (1:1:3).
Structure, properties, spectra, suppliers and links for: 4-[(5-{[5-(2,4-Dichlorophenyl)-3,4-dihydro-2(1H)-isoquinolinyl]methyl}-1H-imidazol-1-yl)methyl]b.
Get Acridinium at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and lab supplies. Spectrum Chemical offers fine chemicals in lab and production sizes.
(E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phenyl}-6-pyridin-3-yl-hex-5-enoic acid amide | C25H26ClN3O3S | CID 10254733 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Fluorescent staining of chromosomes and nuclear structures (nucleolus associated chromatin) in living HeLa- and LM-cells (mouse fibroblasts) with new acridine dyes is reported. The dyes have...
This Ambrosial Oranges recipe is so delicious and full of flavor. Its one of the many great recipes shared by home cooks on BakeSpace.com, the worlds sweetest recipe swap community.
This is now a public advertisement for the role of illustrator for my cartoons. I cant keep copy-pasting from Cyanide and Happiness and I cant keep calling my strip such an obviously ripped-off name. So, if you like to (and can, thats important) draw; if you have high hopes and low expectations; and if your…
TY - JOUR. T1 - Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition. AU - Ponder, Jessica. AU - Yoo, Byong Hoon. AU - Abraham, Adedoyin D.. AU - Li, Qun. AU - Ashley, Amanda K.. AU - Amerin, Courtney L.. AU - Zhou, Qiong. AU - Reid, Brian G.. AU - Reigan, Philip. AU - Hromas, Robert. AU - Nickoloff, Jac A.. AU - LaBarbera, Daniel V.. PY - 2011/11. Y1 - 2011/11. N2 - Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphimedine potently inhibits TopoIIá-dependent DNA decatenation in the presence of Metnase. Cell proliferation assays demonstrate that neoamphimedine can inhibit Metnase-enhanced cell growth with an IC 50 of 0.5 μM. Additionally, we find that the apparent K m of TopoIIα for ATP ...
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DISEASE CHARACTERISTICS: Histologically confirmed metastatic breast cancer Bidimensionally measurable disease of any of the following types required: Bidimensionally measurable lung lesions on chest X-ray, CT scan, or MRI Palpable and quantifiable lymph nodes at least 2 x 2 cm Abdominal mass at least 2 x 2 cm quantifiable by CT scan Bidimensionally measurable liver metastases at least 2 x 2 cm Palpable hepatomegaly if liver edge is clearly defined and extends at least 5 cm below the costal margin of the xiphoid process Unacceptable as measurable disease: Diffuse lung infiltration or unidimensionally measurable hilar lesions Pelvic mass of indefinite dimension Bone metastases Pleural effusion or ascites No brain metastases Must have failed or progressed on prior therapy or relapsed less than 12 months after therapy discontinuation Hormone receptor status: Not specified. PATIENT CHARACTERISTICS: Age: 16 and over Sex: Female Menopausal status: Not specified Performance status: SWOG 0-2 Life ...
methyl 4-(acridin-9-ylamino)benzoate | C21H16N2O2 | CID 39930 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Components: s2146 Acridine Orange Stock Solution s1656 Sorensens Phosphate Buffer pH 6.0 s2147 Calcium Chloride 0.1M Solution s100 Acetic Acid 1% Aqueous
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.
DNA intercalating dye. A grade of acridine orange of exceptionally high purity, suitable for quantitative work. Free of inorganic salts.
17784-47-3 - XUESTGHCVFYOLL-UHFFFAOYSA-N - Acridine, hydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Name:C.I.Basic Orange 14,C.I.46005 Molecular Structure: Acridines class C.I.Basic Orange 14,C.I.46005,CAS 65-61-2,301.81,C17H20ClN3,Acridine Orange C.I.Basic Orange 14,C.I.46005,CAS 65-61-2,301.81,C17H20ClN3,Acridine Orange Molecular Formula:C17H20ClN3 Molecular Weight: 301.81 CAS Registry Number:65-61-2
Herein, six ruthenium(ii) terpyridine complexes, i.e. [RuCl2(4-EtN-Phtpy)(DMSO)] (Ru1), [RuCl2(4-MeO-Phtpy)(DMSO)] (Ru2), [RuCl2(2-MeO-Phtpy)(DMSO)] (Ru3), [RuCl2(3-MeO-Phtpy)(DMSO)] (Ru4), [RuCl2(1-Bip-Phtpy)(DMSO)] (Ru5), and [RuCl2(1-Pyr-Phtpy)(DMSO)] (Ru6) with 4′-(4-diethylaminophenyl)-2,2′:6′,2′′-terpyridine
10-Bromonaphth[2,3-c]acridine-5,8,14(13H)-trione/ACM52636596 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
These orange jelly-like apothecia grow at the apex of the moss Ulota crispa. Spores measure 60-70 x 11 microns. Multiseptate. Multiguttulate. Any suggestion?
Acridine orange is a nucleic acid staining dye that is used to identify dead cells. It intercalates with the double-stranded DNA base pairs at a ratio of 1:3 and is capable of emitting green fluorescence (Ex: 500 nm, Em: 520 nm). It also emits red fluorescence (Ex: 460 nm, Em: 650 nm) when bound to RNA or single-stranded DNA. Since acridine orange is mutagenic, this product is supplied as a solution that prevents it from splashing during weighing.. ...
Short Duration Bath (2 hours) - Using an independent, separate treatment container with appropriate aeration, prepare as 10 part per million (ppm) treatment bath. Note: 10 ppm is equivalent to 10 milligrams of acriflavine per liter of treatment water or 37.8 mg per gallon of treatmet water. After 2 hours of treatment, return fish to habitat water ...
SHREEJI PHARMA International based in Gujarat, India is a manufacturer, exporter & trader of Acriflavine Neutral BPC-49 (Euflavine) at the best price.
The suggestions in this document are based on feedback we have received primarily from DACA renewal applicants. If you have any additional suggestions or feedback, please email the National Immigration Law Center (NILC) at [email protected].. Have your Deferred Action for Childhood Arrivals (DACA) and employ-ment authorization document (EAD) expired, or will they expire soon? If you have submitted your renewal application but are concerned because your DACA and work authorization have expired or will expire before your DACA is renewed, consider following the steps described below to get information about the status of your renewal application and, if appropriate, to ask U.S. Citizenship and Immigration Services (USCIS) to process your renewal more quickly.. USCIS suggests that you submit your completed renewal application at least 150 days (5 months), but no later than 120 days (4 months), before your current DACA and employment authorization document (EAD) expire. USCIS will accept your renewal ...
We have a goldfish that is white with a couple of splashes of orange on him...Over the last week we have noticed that his face and the beginning of his tail is turning yellow?
Mejî an mêşik, endamek ji laşê mirov û lawiran e ku dikeve nav kilox an tasa serî û kontrola sîstema demarî ya navendî dikit. Mejî endamê şirocekirina hestan û bersivandina li goreyê wan e. Mejî navenda kontrolkirina sîstema demarî ya navendî di lawiran da ye. Mejî di mirovan da endamê hizirînê ye û bi kiloxî dihêt parastin. Di piraniya lawiran da mejî nêzî endamên hestyarên serekî ji bo estên mîna bînahî, bîstahî, bêhnahî, hevsengî û çêşahiyê ye. Herçend e ko piraniya movikdaran mejî heye, nemovikdaran gelek caran tenê gilolik anko girêyeka rehikan heye. Hindek ji lawirên gelek despêkanî mîna îsfenciyan hema her mejî nîne. Mejî yê lawirên bêmovik (mîna kêzikan) dikarit gelek sade bit û tenê çend demarek bin. Lê di mirovan da, zêdetir ji 100 milyon demaran di mêjî da hene. ...
... - Cu caracter de invazie, agresivitate. O procedura medicala este invaziva, daca realizarea ei presupune lezare tisulara sau un disconfort fizic semnificativ
Nu stiu daca se pun si sarbatorile anuale insa eu va doresc Sarbatori fericite ,Paste fericit cu familiile voastre.Sarbatori fericite din partea mea ...
Looking for online definition of acridine in the Medical Dictionary? acridine explanation free. What is acridine? Meaning of acridine medical term. What does acridine mean?
... ,Application: Acridine orange has been used as a fluorescent stain for nucleic acids in agarose and polyacrylamide gels. Acridine orange at a concentration of 120 μM will detect purified DNA in gels with a sensitivity of 25-50 ng per band. It has also been used extensively for cell staining of,biological,biology supply,biology supplies,biology product
We do routinely use acridine orange using FACScan. A 20 min rinse with 10 times water-diluted Chlorox bleach is adequate to clean the instrument. Zbigniew Darzynkiewicz -----Original Message----- From: Karen Creswell [mailto:creswelk at georgetown.edu] Sent: Friday, June 04, 2004 1:17 PM To: cyto-inbox Subject: Acridine Orange Does anyone routinely run acridine orange through their FACScan/FACSort? I would like suggestions for cleaning the instrument afterwards. Thanks for your help, Karen -- Karen Creswell, Ph.D. Director, Flow Cytometry/Cell Sorting Shared Resource Lombardi Cancer Center Georgetown University Medical Center Research Bldg W304 Box 571469 Washington, DC 20057-1469 202-687-2233 creswelk at georgetown.edu ...
Comprehensive supplier list for Boronic acid, B-[4-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]phenyl]-,Boronic acid, B-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-
GF120918 has a high inhibitory effect on P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). We developed [11C]GF120918 as a positron emissi
63019-59-0 - RGDUWGJRJSZSLI-LGMDPLHJSA-N - Benz(a)acridine, 12-(p-(dimethylamino)styryl)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Antitumor properties of the potent G‐quadruplex ligand 3,11‐difluoro‐6,8, 13‐trimethyl‐8H‐quino[4,3,2‐kl]acridinium methosulfate (RHPS4) are driven by telomere uncapping events. RHPS4 has good selectivity for quadruplex DNA over duplex DNA as measured by surface plasmon resonance (Kquad 1.1 × 107 M−1); Kdup 3.4 × 105 M−1). In preclinical models of solid tumor xenografts RHPS4 potentiates the activity of camptothecins but good response is dependent on the timing of the drug sequence employed. These experiments teach how an agent of this novel class might be used clinically in combination with chemotherapeutic agents. Although RHPS4 has several drug‐like qualities (synthetic accessibility, water solubility, cellular uptake), a preliminary toxicological study revealed that the compound is a potent hERG inhibitor (IC50 0.2 M) and has additional receptor interactions, notably with muscarinic M1, M2 and M3 receptors. In an anaesthetized guinea pig cardiac model RHPS4 increased ...
Color your world with crystal light and transform ordinary water with fabulous fruit flavors and tantalizing teas. Each sip is the perfect way to refresh, renew and satisfy your thirst for something different. Crystal light. Its lively & unexpected, just like you! This product 5 calories. Leading beverages 70 calories ...
Copyright The Student Room 2017 all rights reserved. The Student Room, Get Revising and Marked by Teachers are trading names of The Student Room Group Ltd.. Register Number: 04666380 (England and Wales), VAT No. 806 8067 22 Registered Office: International House, Queens Road, Brighton, BN1 3XE. ...
Sigma-Aldrich offers Aldrich-A38401, 9-Aminoacridine hydrochloride monohydrate for your research needs. Find product specific information including CAS, MSDS, protocols and references.
my Medium Plus is looking a bit too light or my skin right now. It looks fine when I first apply it, but out in daylight the color is a bit off. My skin now is about NC35... anyone in that range wear Medium Dark in MSFN? some users on MUA have said this turns orange on them.. anyone here have ...
My g/fs step dad has a 30-35g tank with 3 or 4 goldfish and 2 others of a different kind. I notced his goldfish arent lookin really gold. They look awful, more like silver fish with spots of orange on em. One goldfish has a black patch covering most of the top of him and his head. His tank looks awful. The walls look like they never been scrubbed. Ibelieve hes running a aquaclear 200 if I remmebr correctly. But the media looks disgusting. I remmebr he had a Betta in their awhile back and it
If we want potatoes and oranges on grocery shelves 10 years from now, were going to have to dig in to some inconvenient science.
Fluorescent micrographs and quantitative analysis of CAOV-3 cells double-stained with acridine orange and propidium iodide. Cells were treated with liriodenine
As the situation with COVID-19 continues to unfold in every community, MedChemExpress is responding to the uncertainty caused by this outbreak thoughtfully and cautiously. Your need for high quality reagent doesnt stop during difficult times, and neither do we. Were doing our best to keep everyone healthy and safe in the workplace while also avoiding the interruptions to our day-to-day operations. If you need to change the delivery plan for items ordered, please contact us via email [email protected]. Thank you for being a loyal MedChemExpress customer, we are here to assist you as needed. ...
It is designed to maintain a strong seal in cold climates and applications where significant cooling occurs due to high pressure drop.
Acridine orange[edit]. Acridine orange (AO) is a nucleic acid selective fluorescent cationic dye useful for cell cycle ... The stain may also be used in conjunction with acridine orange (AO) in viable cell counting. This EB/AO combined stain causes ...
Ferguson LR, Denny WA (September 1991). "The genetic toxicology of acridines". Mutation Research. 258 (2): 123-60. doi:10.1016/ ... Most intercalators are aromatic and planar molecules; examples include ethidium bromide, acridines, daunomycin, and doxorubicin ...
It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial ...
The possibility for extended planar aromatic systems such as acridine (dibenzo[b,e]pyridine) to insert between base pairs was ... Lerman, L. S. (1963). "The Structure of the DNA-Acridine Complex". Proceedings of the National Academy of Sciences of the ... Lerman, L. S. (1961). "Structural Considerations in the Interaction of DNA and Acridines". Journal of Molecular Biology. 3 (1 ...
Acridine is an isomer of phenanthridine. Phenanthridine was discovered by Amé Pictet and H. J. Ankersmit in 1891 by pyrolysis ...
Examples include ethidium bromide and acridine. An unnatural base pair (UBP) is a designed subunit (or nucleobase) of DNA which ...
Acta 883: 173-177 Notes Darzynkiewicz Z, Kapuscinski J. (1990)"Acridine Orange, a Versatile Probe of Nucleic Acids and Other ... Another example of metachromatic dye (fluorochrome) is acridine orange. Under certain conditions it stains single-stranded ...
... is also a precursor to certain acridine dyes. Via aldol condensations, benzaldehyde is converted into derivatives ...
Darzynkiewicz Z, Kapuscinski J. (1990)"Acridine Orange, a Versatile Probe of Nucleic Acids and Other Cell Constituents." ... Another example of metachromatic dye (fluorochrome) is acridine orange. Under certain conditions it stains single-stranded ...
Lerman, L. S. (1963). "The structure of the DNA-acridine complex". Proc. Natl. Acad. Sci. USA. 49: 94-102. doi:10.1073/pnas. ... Lerman, L. S. (1961). "Structural considerations in the interactions of deoxyribonucleic acid and acridines". Journal of ...
Lerman, L. S. (1963). "The structure of the DNA-acridine complex". Proceedings of the National Academy of Sciences of the ... Lerman, L. S. (1961). "Structural considerations in the interaction of DNA and acridines" (PDF). Journal of Molecular Biology. ... 9 epoxide of aflatoxin B1 and acridines such as proflavine or quinacrine. Intercalation as a mechanism of interaction between ...
Derivatives are formed in moderate to good yield; acridine is essential for high reaction efficiency. Jiao et al. enabled the ...
9 epoxide of aflatoxin B1 and acridines such as proflavine or quinacrine. ... "The structure of the DNA-acridine complex". Proceedings of the National Academy of Sciences of the United States of America ... "Structural considerations in the interaction of DNA and acridines" (PDF). Journal of Molecular Biology. 3 (1): 18-30. doi ...
Hathaway WE, Newby LA, Githens JH (1964). "THE ACRIDINE ORANGE VIABILITY TEST APPLIED TO BONE MARROW CELLS. I. CORRELATION WITH ...
He discovered the therapeutic qualities of acridine dyes. He was born on 21 May 1881 the son of Hugh Hamilton Browning MA BD ( ...
Acridine derivatives: proflavin, acridine orange, acridine yellow, etc. Arylmethine derivatives: auramine, crystal violet, ...
"Synthesis of Twisted Intercalating Nucleic Acids Possessing Acridine Derivatives. Thermal Stability Studies." Bioconjugate Chem ...
"Optically Enhanced Nuclear Cross Polarization in Acridine-Doped Fluorene" (PDF). Retrieved 2012-08-20. https://pines.berkeley. ...
Known clastogens include acridine yellow, benzene, ethylene oxide, arsenic, phosphine and mimosine. Exposure to clastogens ...
Cell apoptosis is tested by treating the lysosomal membrane with acridine orange. Acridine orange radiates a red fluorescent ...
M Garciafernandez; D Ceccarelli; U Muscatello (2004). "Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative ... Jacobson J, Duchen MR, Heales SJ (2002). "Intracellular distribution of the fluorescent dye nonyl acridine orange responds to ... Based on this special structure, the fluorescent mitochondrial indicator, nonyl acridine orange (NAO) was introduced in 1982, ... and LM-cells with new acridine dyes". Histochemistry. 74 (1): 1-7. PMID 7085344. Thomas H. Haines; Norbert A. Dencher (2002). " ...
4-diaminotoluene with acetaldehyde gives the acridine dye called Basic Yellow 9. "NIOSH Pocket Guide to Chemical Hazards #0620 ...
"Comparative Chemogenomics To Examine the Mechanism of Action of DNA-Targeted Platinum-Acridine Anticancer Agents". ACS Chem. ...
"Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents". ACS Chemical ...
He was the first to isolate acridine and "Caro's acid" (peroxymonosulfuric acid) is named after him. Nikodem Caro, co-inventor ...
... has role genotoxin (CHEBI:50902) acridine (CHEBI:36420) is a acridines (CHEBI:22213) acridine (CHEBI: ... CHEBI:36420 - acridine. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ...
Acridine is easily oxidized by peroxymonosulfuric acid to the acridine amine oxide. The carbon 9-position of acridine is ... biologically active acridines, applications of acridines, new syntheses and reactions of acridines] Synthesis of acridone in ... Acridine and its homologues are weakly basic. Acridine is a photobase which have a ground state pKa of 5.1, which is similar to ... Acridine and related derivatives (such as amsacrine) bind to DNA and RNA due to their abilities to intercalate. Acridine orange ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Acridine yellow damages DNA and is used as a mutagen in microbiology. Acridine yellow is similar to acridine orange. Acridine ... Acridine yellow, also known as acridine yellow G, acridine yellow H107, basic yellow K, and 3,6-diamino-2,7-dimethylacridine, ... It is a derivate of acridine. In histology, it is used as a fluorescent stain, and as a fluorescent probe for non-invasive ...
Acridine Carboxamide - DACA. A substance that is being studied as an anticancer drug. It belongs to the family of drugs called ... Medical Word - Acridine Carboxamide. Ans : DACA. A substance that is being studied as an anticancer drug. It belongs to the ... Acridine Carboxamide - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review ...
... acridine-4-carboxamide) is an chemotherapy agent that is being studied in the treatment ... Acridine carboxamide (N-[(2-dimethylamino)ethyl]acridine-4-carboxamide) is an chemotherapy agent that is being studied in the ... It uses material from the Wikipedia article "Acridine_carboxamide". A list of authors is available in Wikipedia. ... Acridine carboxamide Acridine carboxamide (N-[(2-dimethylamino)ethyl] ...
BENZ[a]ACRIDINE. VOL.: 32 (1983) (p. 123) CAS No.: 225-11-6. Chem. Abstr. Name: Benz(a)acridine. 5. Summary of Data Reported ... There is inadequate evidence that benz[a]acridine is active in short-term tests. 5.2 Human data. Benz[a]acridine is present as ... Benz[a]acridine was inadequately tested for carcinogenicity in one experiment by skin application to mice. No data on the ... The available data are inadequate to permit the evaluation of the carcinogenicity of benz[a]acridine in experimental animals. ...
Acridine orange has been used as a fluorescent stain for nucleic acids in agarose and polyacrylamide gels. Acridine orange at a ... Acridine Orange hemi(zinc chloride) salt from Sigma-Aldrich,Application: ... Acridine orange; 10 mg/mL solution in water from AnaSpec. 2. Acridine orange 10-nonyl bromide from AnaSpec. 3. Acridine orange ... Acridine orange at a concentration of 120 μM will detect purified DNA in gels with a sensitivity of 25-50 ng per band. It has ...
... acridine hydrochloride zinc chloride double salt (CAS 10127-02-3), a cell-permeable metachromatic fluorescent cationic DNA and ... Acridine orange for cell sorting of sputum.. J Histochem Cytochem 27:552-6 (1979). Read more (PubMed: 86576) » ... The use of thionin and acridine orange in staining semithin sections of plant material embedded in epoxy resin.. Stain Technol ... Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. ...
The use of acridine orange stained buffy coat smears was assessed as a rapid screening test for bacteremia in adults. A total ... Rapid Diagnosis of Bacteremia in Adults Using Acridine Orange Stained Buffy Coat Smears. Mark Miller1,2 and Jack Mendelson1 ... Compared to blood culture, the overall sensitivity of acridine orange stained buffy coat smears was 16%, specificity 88%, and ... from which a buffy coat smear was prepared and stained with acridine orange (100 mg/L; pH 3.0). Forty-one of 356 blood samples ...
... acridine , C27H15N , CID 186220 - structure, chemical names, physical and chemical properties, classification, patents, ...
Acridine, 1,2,3,4-tetrahydro-, 10-oxide , C13H13NO , CID 168170 - structure, chemical names, physical and chemical properties, ...
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and ... Acridine Diamine, Tetramethyl; Base, Acridine Orange; Diamine, Tetramethyl Acridine; Orange 3RN, Basic; Orange Base, Acridine; ... Acridine Orange. Subscribe to New Research on Acridine Orange A cationic cytochemical stain specific for cell nuclei, ... 3,6-Bis(dimethylamino)acridine; Acridine Orange Base; Basic Orange 3RN; C.I. 46005; C.I. Basic Orange 14; Rhoduline Orange; ...
... Joanne Lannigan joannelannigan at virginia.edu Mon Jun 7 15:20:40 EST 2004 *Previous message: Acridine Orange ... Acridine Orange , , Does anyone routinely run acridine orange through their , FACScan/FACSort? I would like suggestions for ...
... DARZYNKIEWICZ ZBIGNIEW Z_DARZYNKIEWICZ at nymc.edu Mon Jun 7 14:47:50 EST 2004 *Previous message: Parts to ... Acridine Orange Does anyone routinely run acridine orange through their FACScan/FACSort? I would like suggestions for cleaning ... We do routinely use acridine orange using FACScan. A 20 min rinse with 10 times water-diluted Chlorox bleach is adequate to ...
9-acridinecarboxylic acid hydrate, acridine-9-carboxylic acid hydrate, acmc-1afs1, c14h9no2.h2o, acridin-9-carboxylic acid ... 9-acridinecarboxylic acid hydrate, acridine-9-carboxylic acid hydrate, acmc-1afs1, c14h9no2.h2o, acridin-9-carboxylic acid ... 9-acridinecarboxylic acid hydrate, acridine-9-carboxylic acid hydrate, acmc-1afs1, c14h9no2.h2o, acridin-9-carboxylic acid ... hydrate, 9-acridinecarboxylic acid hydrate, acridine-9-carboxylic acid hydrate 1:x. ...
Diagnosis of malaria by acridine orange fluorescent microscopy in an endemic area of venezuela.. Bosch I1, Bracho C, Pérez HA. ... Fluorescent (acridine orange) microscopical examination of capillary centrifuged blood (quantitative buffy coat [QBC] analysis ...
... acridine yellow explanation free. What is acridine yellow? Meaning of acridine yellow medical term. What does acridine yellow ... Looking for online definition of acridine yellow in the Medical Dictionary? ... Acridine yellow , definition of acridine yellow by Medical dictionary https://medical-dictionary.thefreedictionary.com/acridine ... acridine yellow. Also found in: Wikipedia. ac·ri·dine yel·low. (akri-dēn yelō), A faintly yellow solution with strong bluish- ...
Prototropic interactions of pyrimidine nucleic acid bases with acridine: a spectroscopic investigation. Download Prime PubMed ... Photophysical behavior of acridine with amines within the micellar microenvironment of SDS: a time-resolved fluorescence and ... Prototropic interactions of pyrimidine nucleic acid bases with acridine: a spectroscopic investigation.. J Phys Chem B. 2012 ... "Prototropic Interactions of Pyrimidine Nucleic Acid Bases With Acridine: a Spectroscopic Investigation." The Journal of ...
A grade of acridine orange of exceptionally high purity, suitable for quantitative work. Free of inorganic salts. ... Polysciences grade of acridine orange is of exceptionally high purity, suitable for quantitative work. It is free of inorganic ... Acridine orange is a nucleic acid-selective fluorescent cationic dye useful for cell cycle determination. It emits green ... We offer a highly purified form of acridine orange while most of the other commercially available grades are either of low ...
... acridine explanation free. What is acridine? Meaning of acridine medical term. What does acridine mean? ... Looking for online definition of acridine in the Medical Dictionary? ... acridine. Also found in: Dictionary, Encyclopedia, Wikipedia.. Related to acridine: acridine dyes anthracene. [an´thrah-sēn] a ... acridine. /ac·ri·dine/ (ak´rĭ-dēn) an alkaloid from anthracene used in the synthesis of dyes and drugs.. acridine. [ak′ridēn] ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
4,11-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione EC Number:. 221-423-9. EC Name:. 4,11-dichloro-5,12-dihydroquino[2,3- ... 4,11-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dioneacridine-7,14-dioneacridine-7,14-dione
4,11-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione. Regulatory process names 1 CAS names 1 IUPAC names 2 Other ...
The acridine ring in is 9-amino-6-chloro-2-methoxyacridine. This residue is the most popular acridine residue, which is often ... Still Faster Photocontrolled Cleavage by Use of More Active Acridine Residue. The acridine residue used in the above ... In our previous studies optimizing the structure of the acridine ring and the linker moiety, far more active acridine residue ( ... Figure 4: Structures of the modified DNA bearing more active acridine (. ) and the two azobenzene residues (. and ). ...
  • OBJECTIVES: I. Determine the effect of acridine carboxamide on objective response, response rate, and duration of response in patients with unresectable, locally advanced, progressive or metastatic non-small cell lung cancer. (knowcancer.com)
  • Liapunova E.A., Zelenin A.V., The effect of acridine orange on the early steps of protein biosynthesis in tissue culture cells, Voprosy meditsinskoi khimii, 1966, vol: 12(2), 218-220. (msk.ru)
  • In the Bernthsen acridine synthesis, diphenylamine is condensed with carboxylic acids in the presence of zinc chloride. (wikipedia.org)
  • Other older methods for the organic synthesis of acridines include condensing diphenylamine with chloroform in the presence of aluminium chloride, by passing the vapours of orthoaminodiphenylmethane over heated litharge, by heating salicylaldehyde with aniline and zinc chloride or by distilling acridone (9-position a carbonyl group) over zinc dust. (wikipedia.org)
  • 2,7-Bis(alloxycarbonylamino)-9-(biotinylaminoethylamino)acridine (cas# 1219125-65-1) is a compound useful in organic synthesis. (trc-canada.com)
  • An interesting such application is the use of acridine-labeled primers to study non-enzymatic-template-directed RNA synthesis to provide experimental support for theories concerning possible replication of genetic information by early life forms on Earth (5). (genelink.com)
  • The use of acridine orange stained buffy coat smears was assessed as a rapid screening test for bacteremia in adults. (hindawi.com)
  • Direct staining of blood smears with acridine orange and enumeration using fluorescent microscopy allowed quantitation of Haemophilus influenzae in blood at densities from 10(5) to 10(8) cfu/ml. (curehunter.com)
  • Fluorescent (acridine orange) microscopical examination of capillary centrifuged blood (quantitative buffy coat [QBC] analysis) and Giemsa stained thick blood smears (GTS) were compared for diagnosis of malaria in blood specimens from adults living in malaria transmission areas of the States of Bolivar and Amazonas in southeastern and south Venezuela, respectively. (nih.gov)
  • Comparison of the automicrobic system, acridine orange-stained smears, and gram-stained smears in detecting bacteriuria. (asm.org)
  • Benz[ a ]acridine was inadequately tested for carcinogenicity in one experiment by skin application to mice. (inchem.org)
  • The single report of the mutagenicity of benz[ a ]acridine in Salmonella typhimurium was inconclusive. (inchem.org)
  • There is inadequate evidence that benz[ a ]acridine is active in short-term tests. (inchem.org)
  • Benz[ a ]acridine is present as a minor component of the total content of polynuclear aromatic compounds in the environment. (inchem.org)
  • Human exposure to benz[ a ]acridine occurs primarily through inhalation of polluted air and by ingestion of food and water contaminated with combustion products. (inchem.org)
  • The available data are inadequate to permit the evaluation of the carcinogenicity of benz[ a ]acridine in experimental animals. (inchem.org)
  • Among the benz[a]acridines studied, 5,6-dihydro-3,4- methylenedioxy-9,10-dimethoxybenz[a]acridine, 13e, was the most potent topo I poison, with comparable potency to coralyne. (elsevier.com)
  • We have recently developed efficient artificial systems for site-selective RNA scission by combining a metal ion (lanthanide ions or some transition metal ions) as molecular scissor and an acridine-modified DNA as a sequence selective RNA activator [ 5 ]. (hindawi.com)
  • Labeling of DNA oligos with acridine allows them to rapidly and stably intercalate into a target dsDNA molecule, adding increased stability to the double helix (1). (genelink.com)
  • These results indicate that acridine and dinitroaniline herbicides with the plant extracts are promising lead compounds for development as novel antileishmanial agents. (thefreedictionary.com)
  • To further investigate their antiproliferative activities, we have assessed the antiproliferative activity of these acridine-based compounds against several pancreatic cancer cell lines. (umn.edu)
  • In light of the potential importance of the anticancer activity of these acridine-based compounds, we have conducted a series of biochemical assays to determine the effect of these compounds on human topoisomerase II. (umn.edu)
  • Thus, these novel acridine-based compounds with anti-pancreatic cancer activity are catalytic inhibitors, not poisons, of human topoisomerase II. (umn.edu)
  • Acridine is a photobase which have a ground state pKa of 5.1, which is similar to that of pyridine, and have an excited state pKa of 10.6. (wikipedia.org)
  • ClC-3 overexpression increased the acidity of intracellular vesicles, as assessed by acridine orange staining, and enhanced resistance to the chemotherapeutic drug etoposide by almost doubling the IC 50 in either BON or HEK293 cell lines. (aacrjournals.org)
  • One significant advantage of this system is that any desired function can be added to it by additional modification to the acridine-modified DNA. (hindawi.com)
  • Here we present the pure-rotational spectrum of the acridine monomer recorded with a direct absorption mm/sub-mm wave spectrometer and discuss the results in the context of future applications to coherent control of large amplitude motions of small aromatic water clusters. (osu.edu)