A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.
Acridines which are substituted in any position by one or more amino groups or substituted amino groups.
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
Topical antiseptic used mainly in wound dressings.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
A topically applied anti-infective agent.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
Chemical substances that interrupt pregnancy after implantation.
PHENOTHIAZINES with an amino group at the 3-position that are green crystals or powder. They are used as biological stains.
Plasmids which determine the ability of a bacterium to ferment lactose.
Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. Many of them are naturally occurring alkaloids.
Products of the hydrolysis of chlorophylls in which the phytic acid side chain has been removed and the carboxylic acids saponified.
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Strong alkylating and immunosuppressive agents whose biological activity is based on the presence of bis(2-chloroethyl)- groups. Although otherwise structurally diverse, the compounds have in common the capacity to contribute alkyl groups to DNA. They are generally highly toxic but include among their number many widely used and effective antineoplastic agents.
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
An aniline dye used as a disinfectant and an antiseptic agent. It is weakly fluorescing and binds specifically to certain proteins.
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.
Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
A neoplasm containing HISTIOCYTES. Important forms include BENIGN FIBROUS HISTIOCYTOMA; and MALIGNANT FIBROUS HISTIOCYTOMA.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Compounds that inhibit the activity of DNA TOPOISOMERASES.
Inorganic compounds that contain zinc as an integral part of the molecule.
Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.
A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
A plant species of the genus CITRUS, family RUTACEAE that provides the familiar orange fruit which is also a source of orange oil.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A federal area located between Maryland and Virginia on the Potomac river; it is coextensive with Washington, D.C., which is the capital of the United States.
Small computers that lack the speed, memory capacity, and instructional capability of the full-size computer but usually retain its programmable flexibility. They are larger, faster, and more flexible, powerful, and expensive than microcomputers.
A republic in the north of South America, east of VENEZUELA and west of SURINAME. Its capital is Georgetown.
A republic of southeast Asia, northwest of Thailand, long familiar as Burma. Its capital is Yangon, formerly Rangoon. Inhabited by people of Mongolian stock and probably of Tibetan origin, by the 3d century A.D. it was settled by Hindus. The modern Burmese state was founded in the 18th century but was in conflict with the British during the 19th century. Made a crown colony of Great Britain in 1937, it was granted independence in 1947. In 1989 it became Myanmar. The name comes from myanma, meaning the strong, as applied to the Burmese people themselves. (From Webster's New Geographical Dictionary, 1988, p192 & Room, Brewer's Dictionary of Names, 1992, p367)
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)

Characterization of nuclear structures containing superhelical DNA. (1/786)

Structures resembling nuclei but depleted of protein may be released by gently lysing cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids sediment in gradients containing intercalating agents in a manner characteristic of DNA that is intact, supercoiled and circular. The concentration of salt present during isolation of human nucleoids affects their protein content. When made in I-95 M NaCl they lack histones and most of the proteins characteristic of chromatin; in 1-0 M NaCl they contain variable amounts of histones. The effects of various treatments on nucleoid integrity were investigated.  (+info)

Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. (2/786)

Class I P-glycoproteins (Pgp) confer multidrug resistance in tumors, but the physiologic function of Pgp in normal tissues remains uncertain. In cells derived from tissues that normally express Pgp, recent data suggest a possible role for Pgp in cholesterol trafficking from the plasma membrane to the endoplasmic reticulum. We investigated the esterification of plasma membrane cholesterol under basal conditions and in response to sphingomyelinase treatment in transfected and drug-selected cell lines expressing differing amounts of functional class I Pgp. Compared with parental NIH 3T3 fibroblasts, cells transfected with human multidrug resistance (MDR1) Pgp esterified more cholesterol both without and with sphingomyelinase. Esterification also was greater in drug-selected Dox 6 myeloma cells than parental 8226 cells, which express low and non-immunodetectable amounts of Pgp, respectively. However, no differences in total plasma membrane cholesterol were detected. Transfection of fibroblasts with the multidrug resistance-associated protein (MRP) did not alter esterification, showing that cholesterol trafficking was not generally affected by ATP-binding cassette transporters. Steroidal (progesterone, dehydroepiandrosterone) and non-steroidal antagonists (verapamil, PSC 833, LY335979, and GF120918) were evaluated for effects on both cholesterol trafficking and the net content of 99mTc-Sestamibi, a reporter of drug transport activity mediated by Pgp. In Pgp-expressing cells treated with nonselective and selective inhibitors, both the kinetics and efficacy of inhibition of cholesterol esterification differed from the antagonism of drug transport mediated by Pgp. Thus, although the data show that greater expression of class I Pgp within a given cell type is associated with enhanced esterification of plasma membrane cholesterol in support of a physiologic function for Pgp in facilitating cholesterol trafficking, the molecular mechanism is dissociated from the conventional drug transport activity of Pgp.  (+info)

Serum sErbB1 and epidermal growth factor levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. (3/786)

Epithelial ovarian cancer (EOC) has a high mortality rate, which is due primarily to the fact that early clinical symptoms are vague and nonspecific; hence, this disease often goes undetected and untreated until in its advanced stages. Sensitive and reliable methods for detecting earlier stages of EOC are, therefore, urgently needed. Epidermal growth factor (EGF) is a ligand for EGF receptor (ErbB1); this receptor is the product of the c-erbB1 proto-oncogene. ErbB1 overexpression is common in human ovarian carcinoma-derived cell lines and tumors, in which overexpression is thought to play a critical role in tumor etiology and progression. Furthermore, ErbB1 overexpression is associated with disease recurrence and decreased patient survival. Recently, we have developed an acridinium-linked immunosorbent assay that detects a approximately 110-kDa soluble analogue of ErbB1, ie., sErbB1, in serum samples from healthy men and women (A. T. Baron, et al., J. Immunol. Methods, 219: 23-43, 1998). Here, we demonstrate that serum p110 sErbB1 levels are significantly lower in EOC patients with stage III or IV disease prior to (P < 0.0001) and shortly after (P < 0.0001) cytoreductive staging laparotomy than in healthy women of similar ages, whereas EGF levels are significantly higher than those of age-matched healthy women only in serum samples collected shortly after tumor debulking surgery (P < 0.0001). We observe that the preoperative serum sErbB1 concentration range of advanced stage EOC patients barely overlaps with the serum sErbB1 concentration range of healthy women. In addition, we show that serum sErbB1 and EGF levels changed temporally for some EOC patients who were surgically debulked of tumor and who provided a second serum sample during the course of combination chemotherapy. Finally, we observe a significant positive association between sErbB1 and EGF levels only in serum samples of EOC patients collected prior to cytoreductive surgery (correlation coefficient = 0.61968; P = 0.0027). These data suggest that epithelial ovarian tumors concomitantly affect serum sErbB1 and EGF levels. In conclusion, these data indicate that serum sErbB1 and EGF (postoperative only) levels are significantly different between EOC patients and healthy women and that altered and/or changing serum sErbB1 and EGF levels may provide important diagnostic and/or prognostic information useful for the management of patients with EOC.  (+info)

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918. (4/786)

The acridone carboxamide derivative GG918 (N-{4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-pheny l}-9,10dihydro-5-methoxy-9-oxo-4-acridine carboxamide) is a potent inhibitor of MDR1 P-glycoprotein-mediated multidrug resistance. Direct measurements of ATP-dependent MDR1 P-glycoprotein-mediated transport in plasma membrane vesicles from human and rat hepatocyte canalicular membranes indicated 50% inhibition at GG918 concentrations between 8 nM and 80 nM using N-pentyl-[3H]quinidinium, ['4C]doxorubicin and [3H]daunorubicin as substrates. The inhibition constant K for GG918 was 35 nM in rat hepatocyte canalicular membrane vesicles with [3H]daunorubicin as the substrate. Photoaffinity labelling of canalicular and recombinant rat Mdr1b P-glycoprotein by [3H]azidopine was suppressed by 10 muM and 40 muM GG918. The high selectivity of GG918-induced inhibition was demonstrated in canalicular membrane vesicles and by analysis of the hepatobiliary elimination in rats using [3H]daunorubicin, [3H]taurocholate and [3H]cysteinyl leukotrienes as substrates for three distinct ATP-dependent export pumps. Almost complete inhibition of [3H]daunorubicin transport was observed at GG918 concentrations that did not affect the other hepatocyte canalicular export pumps. The high potency and selectivity of GG918 for the inhibition of human MDR1 and rat Mdr1b P-glycoprotein may serve to interfere with this type of multidrug resistance and provides a tool for studies on the function of these ATP-dependent transport proteins.  (+info)

A method for the deductive and unique determination of the values of three parameters involved in fractional functions applicable to relaxation kinetics. (5/786)

A novel method is proposed to determine deductively and uniquely the values of three parameters, a, b, and c in a fractional function of the form, y=a+bx/(c+x) where x and y are experimentally obtainable variables. This type of equation is frequently encountered in chemistry and biochemistry involving relaxation kinetics. The method of least squares with the Taylor expansion is employed for direct curve fitting of observed data to the fractional function. Approximate values of the parameters, which are always necessary prior to commending the above procedure, can be obtained by the method of rearrangement after canceling the denominator of fractional functions. This procedure is very simple, but very effective for estimating provisional values of the parameters. Deductive and unique determination of the parameters involved in the fractional function shown above can be accomplished for the first time by the combination of these two procedures. This method is extended to include the analysis of relaxation kinetic data such as those of temperature-jump method where the determination of equilibrium concentrations of reactants in addition to the three parameters is also necessary.  (+info)

Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. (6/786)

BACKGROUND: Angiotensin II activates NAD(P)H-dependent oxidases via AT1-receptor stimulation, the most important vascular source of superoxide (O2*-). The AT1 receptor is upregulated in vitro by low-density lipoprotein. The present study was designed to test whether hypercholesterolemia is associated with increased NAD(P)H-dependent vascular O2*- production and whether AT1-receptor blockade may inhibit this oxidase and in parallel improve endothelial dysfunction. METHODS AND RESULTS: Vascular responses were determined by isometric tension studies, and relative rates of vascular O2*- production were determined by use of chemiluminescence with lucigenin, a cypridina luciferin analogue, and electron spin resonance studies. AT1-receptor mRNA was quantified by Northern analysis, and AT1-receptor density was measured by radioligand binding assays. Hypercholesterolemia was associated with impaired endothelium-dependent vasodilation and increased O2*- production in intact vessels. In vessel homogenates, we found a significant activation of NADH-driven O2*- production in both models of hyperlipidemia. Treatment of cholesterol-fed animals with the AT1-receptor antagonist Bay 10-6734 improved endothelial dysfunction, normalized vascular O2*- and NADH-oxidase activity, decreased macrophage infiltration, and reduced early plaque formation. In the setting of hypercholesterolemia, the aortic AT1 receptor mRNA was upregulated to 166+/-11%, accompanied by a comparable increase in AT1-receptor density. CONCLUSIONS: Hypercholesterolemia is associated with AT1-receptor upregulation, endothelial dysfunction, and increased NADH-dependent vascular O2*- production. The improvement of endothelial dysfunction, inhibition of the oxidase, and reduction of early plaque formation by an AT1-receptor antagonist suggests a crucial role of angiotensin II-mediated O2*- production in the early stage of atherosclerosis.  (+info)

Paracrine role of adventitial superoxide anion in mediating spontaneous tone of the isolated rat aorta in angiotensin II-induced hypertension. (7/786)

The relationship between vascular generation of superoxide anion and spontaneous tone observed in the isolated aorta was studied in hypertensive rats infused with angiotensin II. Aortic rings from hypertensive, but not from sham-operated rats, demonstrated oscillatory spontaneous tone that represented 52+/-5.6% of the maximal contraction to KCl. Spontaneous tone was prevented by calcium-free buffer or by blocking calcium influx through L-type calcium channels with nifedipine. The production of superoxide anion measured by lucigenin chemiluminescence was up to 15-fold higher than in sham-operated rat aorta. The adventitial site of production of superoxide anion was suggested by the fact that lucigenin chemiluminescence was 5.5-fold higher from the adventitia than from the intima. This was confirmed histochemically by demonstrating that the adventitia was the site of reduction of nitroblue tetrazolium as well as immunohistochemical staining of NAD(P)H oxidase subunit proteins. A causal link between superoxide anion production by NAD(P)H oxidase and the spontaneous tone is suggested by the fact that superoxide dismutase or the inhibitor of NAD(P)H oxidase, diphenylene iodonium, decreased both superoxide anion production and spontaneous tone. L-NAME or removal of the endothelium from the aorta had no significant effect on superoxide anion levels or spontaneous tone. However, although superoxide dismutase decreased superoxide anion levels in the presence of L-NAME or in endothelium-denuded rings, it no longer inhibited the tone. This suggests that the effect on tone of superoxide anion originating in the adventitia is mediated by inactivating endothelium-derived nitric oxide, which promotes smooth muscle calcium influx and spontaneous tone. The adventitia is not a passive bystander during the development of hypertension, but rather it may have an important role in the regulation of smooth muscle tone.  (+info)

Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation. (8/786)

Lucigenin-amplified chemiluminescence has frequently been used to assess the formation of superoxide in vascular tissues. However, the ability of lucigenin to undergo redox cycling in purified enzyme-substrate mixtures has raised questions concerning the use of lucigenin as an appropriate probe for the measurement of superoxide production. Addition of lucigenin to reaction mixtures of xanthine oxidase plus NADH resulted in increased oxygen consumption, as well as superoxide dismutase-inhibitable reduction of cytochrome c, indicative of enhanced rates of superoxide formation. Additionally, it was revealed that lucigenin stimulated oxidant formation by both cultured bovine aortic endothelial cells and isolated rings from rat aorta. Lucigenin treatment resulted in enhanced hydrogen peroxide release from endothelial cells, whereas exposure to lucigenin resulted in inhibition of endothelium-dependent relaxation in isolated aortic rings that was superoxide dismutase inhibitable. In contrast, the chemiluminescent probe coelenterazine had no significant effect on xanthine oxidase-dependent oxygen consumption, endothelial cell hydrogen peroxide release, or endothelium-dependent relaxation. Study of enzyme and vascular systems indicated that coelenterazine chemiluminescence is a sensitive marker for detecting both superoxide and peroxynitrite.  (+info)

Synonyms for acridine dye in Free Thesaurus. Antonyms for acridine dye. 30 synonyms for dye: colour, stain, tint, shade, tinge, pigment, tincture, colour-wash, colouring, colour, pigment, wash, stain, tint, tinge, colorant, color. What are synonyms for acridine dye?
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Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
The objective of this study was to characterize the influence of P-gp and Bcrp at the mouse BBB on the nonlinear CNS distribution of elacridar. This compound has been widely used as a P-gp and Bcrp inhibitor, both in vitro and in vivo. However, the brain distribution of elacridar has not been fully characterized. Earlier studies using radiolabeled elacridar and positron emission tomography qualitatively examined the CNS distribution of elacridar-associated radioactivity in wild-type, P-gp knockout, Bcrp knockout, and triple knockout mice (Dorner et al., 2009; Kawamura et al., 2011a,b). The results from those studies indicated that P-gp and Bcrp could play a role in limiting the brain distribution of elacridar. Our previous study (Sane et al., 2012) was the first to quantitatively examine the brain distribution of elacridar in wild-type mice using a specific stability-indicating assay (LC-MS/MS). The current study examined various factors that could influence elacridar brain distribution, ...
Since the properties of small molecules can change upon conjugation to proteins, we investigated the binding of CB[8] to TMV-6 following the confirmation of the TMV-6 conjugate. Since the solutions of TMV-6 at concentrations required for ITC characterization were subject to viscosity and adhesion issues, a fluorescence titration was used instead to determine a dissociation constant. In this case, neither TMV-6 nor CB[8] contain fluorophores, so a competitive binding strategy incorporating a fluorophore was implemented. Acridine-3,6-diamine, or proflavin (PF), is an acridine derivative that is fluorescent as a free molecule in aqueous solutions, but its fluorescence becomes quenched68,69 upon binding inside the cavity of CB[8]. A fluorescence titration of increasing concentrations of TMV-6 (0-20 μM relative to TEMPO) titrated into solutions with a constant concentration of the CB[8]⊃PF (0.2 μM) complex was performed. Upon the addition of increasing concentrations of TMV-6, the observed ...
Lookchem Provide Cas No.118474-59-2 Basic information: Properties,Safety Data,Sds and Other Datebase. We also Provide Trading Suppliers & Manufacture for 118474-59-2 10-{3-[(2-aminoethyl)amino]propyl}-3,6-bis(dimethylamino)acridinium platinum(2+) chloride (1:1:3).
Structure, properties, spectra, suppliers and links for: 4-[(5-{[5-(2,4-Dichlorophenyl)-3,4-dihydro-2(1H)-isoquinolinyl]methyl}-1H-imidazol-1-yl)methyl]b.
Get Acridinium at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and lab supplies. Spectrum Chemical offers fine chemicals in lab and production sizes.
(E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phenyl}-6-pyridin-3-yl-hex-5-enoic acid amide | C25H26ClN3O3S | CID 10254733 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Fluorescent staining of chromosomes and nuclear structures (nucleolus associated chromatin) in living HeLa- and LM-cells (mouse fibroblasts) with new acridine dyes is reported. The dyes have...
This Ambrosial Oranges recipe is so delicious and full of flavor. Its one of the many great recipes shared by home cooks on BakeSpace.com, the worlds sweetest recipe swap community.
Nearly 50,000 DACA applicants are waiting for their applications to be approved. Theyll have to keep waiting after a judge ruled the program unconstitutional.
Nearly 50,000 DACA applicants are waiting for their applications to be approved. Theyll have to keep waiting after a judge ruled the program unconstitutional.
This is now a public advertisement for the role of illustrator for my cartoons. I cant keep copy-pasting from Cyanide and Happiness and I cant keep calling my strip such an obviously ripped-off name. So, if you like to (and can, thats important) draw; if you have high hopes and low expectations; and if your…
TY - JOUR. T1 - Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition. AU - Ponder, Jessica. AU - Yoo, Byong Hoon. AU - Abraham, Adedoyin D.. AU - Li, Qun. AU - Ashley, Amanda K.. AU - Amerin, Courtney L.. AU - Zhou, Qiong. AU - Reid, Brian G.. AU - Reigan, Philip. AU - Hromas, Robert. AU - Nickoloff, Jac A.. AU - LaBarbera, Daniel V.. PY - 2011/11. Y1 - 2011/11. N2 - Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphimedine potently inhibits TopoIIá-dependent DNA decatenation in the presence of Metnase. Cell proliferation assays demonstrate that neoamphimedine can inhibit Metnase-enhanced cell growth with an IC 50 of 0.5 μM. Additionally, we find that the apparent K m of TopoIIα for ATP ...
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CAS NO:62147-65-3; Chemical name:Acetamide,N-[3,4-dihydro-3-(4-methoxyphenyl)-1-oxo-2(1H)-isoquinolinyl]- ; physical and chemical property of 62147-65-3, Acetamide,N-[3,4-dihydro-3-(4-methoxyphenyl)-1-oxo-2(1H)-isoquinolinyl]- is provided by ChemNet.com
acridine 260-94-6 MSDS report, acridine MSDS safety technical specifications search, acridine safety information specifications ect.
DISEASE CHARACTERISTICS: Histologically confirmed metastatic breast cancer Bidimensionally measurable disease of any of the following types required: Bidimensionally measurable lung lesions on chest X-ray, CT scan, or MRI Palpable and quantifiable lymph nodes at least 2 x 2 cm Abdominal mass at least 2 x 2 cm quantifiable by CT scan Bidimensionally measurable liver metastases at least 2 x 2 cm Palpable hepatomegaly if liver edge is clearly defined and extends at least 5 cm below the costal margin of the xiphoid process Unacceptable as measurable disease: Diffuse lung infiltration or unidimensionally measurable hilar lesions Pelvic mass of indefinite dimension Bone metastases Pleural effusion or ascites No brain metastases Must have failed or progressed on prior therapy or relapsed less than 12 months after therapy discontinuation Hormone receptor status: Not specified. PATIENT CHARACTERISTICS: Age: 16 and over Sex: Female Menopausal status: Not specified Performance status: SWOG 0-2 Life ...
Ø Jagannath has improved resistance to lodging, high yield, more responsive to fertilizers than its parent. Furthermore it was possible to move useful genes by specialbreeding strategies. Plant breeders must be equipped with the tools to respond quickly to new demands by developing accelerated breeding techniques and the ability to screen for traits of interest rapidly among progeny. Ø Mutation breeding can improve the disease resistance of crop plants. Meaning of Hybridization: Individual produced as a result of […] Ø In sexually reproducing plants dominant and recessive mutations are useful. Acridine dyes: Example: Proflavine, Acridine orange, Acridine yellow, Ethydium bromide, (3). Ø The mutation also increases frequency of chromosomal changes, mitotic and meiotic irregularities in the organism. Plant breeders must have access to genetic variation in crop species. The strategies used to meet these demands are increasingly based on our knowledge of relevant science, particularly genetics ...
methyl 4-(acridin-9-ylamino)benzoate | C21H16N2O2 | CID 39930 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Components: s2146 Acridine Orange Stock Solution s1656 Sorensens Phosphate Buffer pH 6.0 s2147 Calcium Chloride 0.1M Solution s100 Acetic Acid 1% Aqueous
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.
DNA intercalating dye. A grade of acridine orange of exceptionally high purity, suitable for quantitative work. Free of inorganic salts.
17784-47-3 - XUESTGHCVFYOLL-UHFFFAOYSA-N - Acridine, hydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Name:C.I.Basic Orange 14,C.I.46005 Molecular Structure: Acridines class C.I.Basic Orange 14,C.I.46005,CAS 65-61-2,301.81,C17H20ClN3,Acridine Orange C.I.Basic Orange 14,C.I.46005,CAS 65-61-2,301.81,C17H20ClN3,Acridine Orange Molecular Formula:C17H20ClN3 Molecular Weight: 301.81 CAS Registry Number:65-61-2
Herein, six ruthenium(ii) terpyridine complexes, i.e. [RuCl2(4-EtN-Phtpy)(DMSO)] (Ru1), [RuCl2(4-MeO-Phtpy)(DMSO)] (Ru2), [RuCl2(2-MeO-Phtpy)(DMSO)] (Ru3), [RuCl2(3-MeO-Phtpy)(DMSO)] (Ru4), [RuCl2(1-Bip-Phtpy)(DMSO)] (Ru5), and [RuCl2(1-Pyr-Phtpy)(DMSO)] (Ru6) with 4′-(4-diethylaminophenyl)-2,2′:6′,2′′-terpyridine
10-Bromonaphth[2,3-c]acridine-5,8,14(13H)-trione/ACM52636596 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
The conductance and switching behaviour of acene series derivative `Acridinium based organic molecular single electron transistor have been assessed in the vic
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
These orange jelly-like apothecia grow at the apex of the moss Ulota crispa. Spores measure 60-70 x 11 microns. Multiseptate. Multiguttulate. Any suggestion?
Acridine orange is a nucleic acid staining dye that is used to identify dead cells. It intercalates with the double-stranded DNA base pairs at a ratio of 1:3 and is capable of emitting green fluorescence (Ex: 500 nm, Em: 520 nm). It also emits red fluorescence (Ex: 460 nm, Em: 650 nm) when bound to RNA or single-stranded DNA. Since acridine orange is mutagenic, this product is supplied as a solution that prevents it from splashing during weighing.. ...
Short Duration Bath (2 hours) - Using an independent, separate treatment container with appropriate aeration, prepare as 10 part per million (ppm) treatment bath. Note: 10 ppm is equivalent to 10 milligrams of acriflavine per liter of treatment water or 37.8 mg per gallon of treatmet water. After 2 hours of treatment, return fish to habitat water ...
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We have a goldfish that is white with a couple of splashes of orange on him...Over the last week we have noticed that his face and the beginning of his tail is turning yellow?
Navberedemax di navbera mejî û beşên din ên koendama demarê de girêdanan ava dike, belavkirina agahiyên ji mejî an jî ber bi mejî li vir rû dide[5]. Ango ji bilî hestê bêhngirtinê, agahiyên ji dirkepetik û demarekoendama çêwe, pêşî li vir tên tekûzkirin û yekkirin paşê tên şandin ji boy mejî[5]. Talamus û hîpotalamus beşên demaxê navberê ne û pêwendiya wan raste rast bi koendama demarê heye. Hestewergir ji her aliyê laş de demareragihandin werdigirin, bi navbeynkariya demarexaneyên hestê, demareragihandin tên şandin boy talamusê. Talamus ragihandinan ji hestedemarexane yên hatî digire, ragihandinan tekûz dike. Li talamusê ragihandinên(kartêkir) girîng ji yê ne girîng tên cihê kirin. Hêza (bandora) ragihandinan tên kêmkirn an jî zêdekirin. Piştî polenkirinê, talamus ragihandinan dişîne boy beşa guncav a tûkila mejîyê[9]. Wekî mînak gava mirov li cihekî qerebalix de hewla xwendina pirtûkek bike, talamus dengên derdorê ...
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Invaziv - Dictionar termeni medicali - Cu caracter de invazie, agresivitate. O procedura medicala este invaziva, daca realizarea ei presupune lezare tisulara sau un disconfort fizic semnificativ
Looking for online definition of acridine in the Medical Dictionary? acridine explanation free. What is acridine? Meaning of acridine medical term. What does acridine mean?
Acridine Orange hemi(zinc chloride) salt from Sigma-Aldrich,Application: Acridine orange has been used as a fluorescent stain for nucleic acids in agarose and polyacrylamide gels. Acridine orange at a concentration of 120 μM will detect purified DNA in gels with a sensitivity of 25-50 ng per band. It has also been used extensively for cell staining of,biological,biology supply,biology supplies,biology product
We do routinely use acridine orange using FACScan. A 20 min rinse with 10 times water-diluted Chlorox bleach is adequate to clean the instrument. Zbigniew Darzynkiewicz -----Original Message----- From: Karen Creswell [mailto:creswelk at georgetown.edu] Sent: Friday, June 04, 2004 1:17 PM To: cyto-inbox Subject: Acridine Orange Does anyone routinely run acridine orange through their FACScan/FACSort? I would like suggestions for cleaning the instrument afterwards. Thanks for your help, Karen -- Karen Creswell, Ph.D. Director, Flow Cytometry/Cell Sorting Shared Resource Lombardi Cancer Center Georgetown University Medical Center Research Bldg W304 Box 571469 Washington, DC 20057-1469 202-687-2233 creswelk at georgetown.edu ...
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Synthesis of carbon-11-labeled tariquidar derivatives as new PET agents for imaging of breast cancer resistance protein (ABCG2). Appl Radiat Isot. 2010 Jun; 68(6):1098-103 ...
GF120918 has a high inhibitory effect on P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). We developed [11C]GF120918 as a positron emissi
63019-59-0 - RGDUWGJRJSZSLI-LGMDPLHJSA-N - Benz(a)acridine, 12-(p-(dimethylamino)styryl)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Antitumor properties of the potent G‐quadruplex ligand 3,11‐difluoro‐6,8, 13‐trimethyl‐8H‐quino[4,3,2‐kl]acridinium methosulfate (RHPS4) are driven by telomere uncapping events. RHPS4 has good selectivity for quadruplex DNA over duplex DNA as measured by surface plasmon resonance (Kquad 1.1 × 107 M−1); Kdup 3.4 × 105 M−1). In preclinical models of solid tumor xenografts RHPS4 potentiates the activity of camptothecins but good response is dependent on the timing of the drug sequence employed. These experiments teach how an agent of this novel class might be used clinically in combination with chemotherapeutic agents. Although RHPS4 has several drug‐like qualities (synthetic accessibility, water solubility, cellular uptake), a preliminary toxicological study revealed that the compound is a potent hERG inhibitor (IC50 0.2 M) and has additional receptor interactions, notably with muscarinic M1, M2 and M3 receptors. In an anaesthetized guinea pig cardiac model RHPS4 increased ...
Some clones, Hfr, were selected, either at high temperature or at low temperature in the presence of acridine on the basis of mutated bacteria whose F episome does not multiply at high temperature in the autonomous state. The integration mechanisms of the episome and of the chromosomal transfer by I strains may be deduced from the properties of these strains. The sex episome of Escherichia coli K 12, in the autonomous state, confers on the bacterium that carries it F the capability of being paired with a bacterium F- and of transferring episome F to it at high frequency. The integration of the episome and of the chromosome creates a new type of male bacterium Hfr, which transfers an oriented group of chromosomal genes at high frequency, but does not transfer the autonomous episome F. A third sexual type, intermediary type I, has also been observed recently. The I bacteria transfer the episome by crossing the autonomous state with the same efficacy as the F bacteria. Like the Hfr bacteria, on the other
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Sigma-Aldrich offers Aldrich-A38401, 9-Aminoacridine hydrochloride monohydrate for your research needs. Find product specific information including CAS, MSDS, protocols and references.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
To peel the oranges cut both ends and place the orange on one end on a cutting board. Using a sharp knife shave the peel off downwards all the way around, making sure to also remove the thin white skin around the orange. Chop the orange into small pieces. Weigh the chopped orange. ...
my Medium Plus is looking a bit too light or my skin right now. It looks fine when I first apply it, but out in daylight the color is a bit off. My skin now is about NC35... anyone in that range wear Medium Dark in MSFN? some users on MUA have said this turns orange on them.. anyone here have ...
My g/fs step dad has a 30-35g tank with 3 or 4 goldfish and 2 others of a different kind. I notced his goldfish arent lookin really gold. They look awful, more like silver fish with spots of orange on em. One goldfish has a black patch covering most of the top of him and his head. His tank looks awful. The walls look like they never been scrubbed. Ibelieve hes running a aquaclear 200 if I remmebr correctly. But the media looks disgusting. I remmebr he had a Betta in their awhile back and it
If we want potatoes and oranges on grocery shelves 10 years from now, were going to have to dig in to some inconvenient science.
Fluorescent micrographs and quantitative analysis of CAOV-3 cells double-stained with acridine orange and propidium iodide. Cells were treated with liriodenine
Acriflavine related products. MedChemExpress provides thousands of inhibitors, modulators and agonists with high purity and quality, excellent customer reviews, precise and professional product citations, tech support and prompt delivery.
It is designed to maintain a strong seal in cold climates and applications where significant cooling occurs due to high pressure drop.
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Acridine orange[edit]. Acridine orange (AO) is a nucleic acid selective fluorescent cationic dye useful for cell cycle ... The stain may also be used in conjunction with acridine orange (AO) in viable cell counting. This EB/AO combined stain causes ...
Ferguson LR, Denny WA (September 1991). "The genetic toxicology of acridines". Mutation Research. 258 (2): 123-60. doi:10.1016/ ... Most intercalators are aromatic and planar molecules; examples include ethidium bromide, acridines, daunomycin, and doxorubicin ...
Bernthsen, August (1884). "Die Acridine". Justus Liebig's Annalen der Chemie (in German). 224 (1-2): 1-56. doi:10.1002/jlac. ... Synthese der Acridine". Berichte der Deutschen Chemischen Gesellschaft (in German). 16 (2): 1802-1819. doi:10.1002/cber. ...
Cairns Smith, A. G. (1957). "Studies in the acridine series". Cite journal requires ,journal= (help) Dennett, Daniel (1996). " ...
It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial ...
Denny (2002). "Acridine Derivatives as Chemotherapeutic Agents". Current Medicinal Chemistry. 9 (18): 1655-65. doi:10.2174/ ... Gatasheh, Mansour K; Kannan, S; Hemalatha, K; Imrana, N (2017). "Proflavine an acridine DNA intercalating agent and strong ...
... also binds to acridine orange. "Duranat Cu Chlorophyllin WSP (Natural Green 3-1 CI 75810-1)". Retrieved 15 ...
Acridine is an isomer of phenanthridine. Phenanthridine was discovered by Amé Pictet and H. J. Ankersmit in 1891 by pyrolysis ...
Examples include ethidium bromide and acridine. An unnatural base pair (UBP) is a designed subunit (or nucleobase) of DNA which ...
Acta 883: 173-177 Notes Darzynkiewicz Z, Kapuscinski J. (1990)"Acridine Orange, a Versatile Probe of Nucleic Acids and Other ... Another example of metachromatic dye (fluorochrome) is acridine orange. Under certain conditions it stains single-stranded ...
... is also a precursor to certain acridine dyes. Via aldol condensations, benzaldehyde is converted into derivatives ...
Darzynkiewicz Z, Kapuscinski J. (1990)"Acridine Orange, a Versatile Probe of Nucleic Acids and Other Cell Constituents." ... Another example of metachromatic dye (fluorochrome) is acridine orange. Under certain conditions it stains single-stranded ...
Lerman, L. S. (1963). "The structure of the DNA-acridine complex". Proc. Natl. Acad. Sci. USA. 49 (1): 94-102. Bibcode:1963PNAS ... Lerman, L. S. (1961). "Structural considerations in the interactions of deoxyribonucleic acid and acridines". Journal of ...
Lerman, L. S. (1963). "The structure of the DNA-acridine complex". Proceedings of the National Academy of Sciences of the ... Lerman, L. S. (1961). "Structural considerations in the interaction of DNA and acridines" (PDF). Journal of Molecular Biology. ... 9 epoxide of aflatoxin B1 and acridines such as proflavine or quinacrine. Intercalation as a mechanism of interaction between ...
It is observed in compounds such as calixarenes and acridines. Peri-substitution occurs in naphthalenes for substituents at the ...
Derivatives are formed in moderate to good yield; acridine is essential for high reaction efficiency. Jiao et al. enabled the ...
9 epoxide of aflatoxin B1 and acridines such as proflavine or quinacrine. ... "The structure of the DNA-acridine complex". Proceedings of the National Academy of Sciences of the United States of America ... "Structural considerations in the interaction of DNA and acridines" (PDF). Journal of Molecular Biology. 3 (1): 18-30. doi ...
Hathaway WE, Newby LA, Githens JH (1964). "THE ACRIDINE ORANGE VIABILITY TEST APPLIED TO BONE MARROW CELLS. I. CORRELATION WITH ...
He discovered the therapeutic qualities of acridine dyes. He was born on 21 May 1881 the son of Friederike Sophia Pauline (née ...
Acridine derivatives: proflavin, acridine orange, acridine yellow, etc. Arylmethine derivatives: auramine, crystal violet, ...
"Synthesis of Twisted Intercalating Nucleic Acids Possessing Acridine Derivatives. Thermal Stability Studies". Bioconjugate ...
Cell apoptosis is tested by treating the lysosomal membrane with acridine orange. Acridine orange radiates a red fluorescent ...
Other organic compounds Acridine has been obtained as seven polymorphs. Glycine crystallizes as both monoclinic and hexagonal ...
Oshiro, C.M. (1 June 1982). Optically enhanced nuclear cross polarization in acridine-doped fluorene (Thesis). doi:10.2172/ ...
Polymorphism of organic substances: acridine, catechol, diphenylamine and suberic acid) -- (1943). "Mikro-Thermoanalyse ...
"Zincate-Mediated Arylation Reactions of Acridine: Pre- and Postarylation Structural Insights" (PDF). Organometallics. 34 (11): ...
Traganos F, Darzynkiewicz Z (1994). "Lysosomal proton pump activity: supravital cell staining with acridine orange ...
His project was a study of the effects of acridines on the replication of bacteriophage T4 DNA. He received his Ph.D. in ...
Clark, Ewan R.; Ingleson, Michael J. (2013-11-25). "[(acridine)BCl2]+: A Borenium Cation That Is a Strong Boron- and Carbon- ...
M Garciafernandez; D Ceccarelli; U Muscatello (2004). "Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative ... Jacobson J, Duchen MR, Heales SJ (2002). "Intracellular distribution of the fluorescent dye nonyl acridine orange responds to ... Keij JF, Bell-Prince C, Steinkamp JA (2000). "Staining of mitochondrial membranes with 10-nonyl acridine orange, MitoFluor ... Based on this special structure, the fluorescent mitochondrial indicator, nonyl acridine orange (NAO) was introduced in 1982, ...
... has role genotoxin (CHEBI:50902) acridine (CHEBI:36420) is a acridines (CHEBI:22213) acridine (CHEBI: ... CHEBI:36420 - acridine. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
... biologically active acridines, applications of acridines, new syntheses and reactions of acridines] Media related to Acridine ... Acridine is easily oxidized by peroxymonosulfuric acid to the acridine amine oxide. The carbon 9-position of acridine is ... Acridine and its homologues are weakly basic. Acridine is a photobase which has a ground state pKa of 5.1, similar to that of ... Acridine and related derivatives (such as amsacrine) bind to DNA and RNA due to their abilities to intercalate. Acridine orange ...
Acridine yellow damages DNA and is used as a mutagen in microbiology. Acridine yellow is similar to acridine orange. Acridine ... Acridine yellow, also known as acridine yellow G, acridine yellow H107, basic yellow K, and 3,6-diamino-2,7-dimethylacridine, ... It is a derivate of acridine. In histology, it is used as a fluorescent stain, and as a fluorescent probe for non-invasive ...
Acridine Carboxamide - DACA. A substance that is being studied as an anticancer drug. It belongs to the family of drugs called ... Medical Word - Acridine Carboxamide. Ans : DACA. A substance that is being studied as an anticancer drug. It belongs to the ... Acridine Carboxamide - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review ...
... acridine-4-carboxamide) is an chemotherapy agent that is being studied in the treatment ... Acridine carboxamide (N-[(2-dimethylamino)ethyl]acridine-4-carboxamide) is an chemotherapy agent that is being studied in the ... It uses material from the Wikipedia article "Acridine_carboxamide". A list of authors is available in Wikipedia. ... Acridine carboxamide Acridine carboxamide (N-[(2-dimethylamino)ethyl] ...
The fluorescence spectra of acridine oligomers were affected strongly upon binding to DNA. These spectral changes were used to ... The synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase ... pKa of acridine-9-carboxylic acid was and 2-(acridine-9-carboxamide)acetic acid We therefore estimated that the acridine rings ... 4 and the acridine monomers acridine-9-carboxylic acid and 2-(acridine-9-carboxamide)acetic acid (Figure 1). Acridine-9- ...
BENZ[a]ACRIDINE. VOL.: 32 (1983) (p. 123) CAS No.: 225-11-6. Chem. Abstr. Name: Benz(a)acridine. 5. Summary of Data Reported ... There is inadequate evidence that benz[a]acridine is active in short-term tests. 5.2 Human data. Benz[a]acridine is present as ... Benz[a]acridine was inadequately tested for carcinogenicity in one experiment by skin application to mice. No data on the ... The available data are inadequate to permit the evaluation of the carcinogenicity of benz[a]acridine in experimental animals. ...
Acridine orange has been used as a fluorescent stain for nucleic acids in agarose and polyacrylamide gels. Acridine orange at a ... Acridine Orange hemi(zinc chloride) salt from Sigma-Aldrich,Application: ... Acridine orange; 10 mg/mL solution in water from AnaSpec. 2. Acridine orange 10-nonyl bromide from AnaSpec. 3. Acridine orange ... Acridine orange at a concentration of 120 μM will detect purified DNA in gels with a sensitivity of 25-50 ng per band. It has ...
... acridine hydrochloride zinc chloride double salt (CAS 10127-02-3), a cell-permeable metachromatic fluorescent cationic DNA and ... Acridine orange for cell sorting of sputum.. J Histochem Cytochem 27:552-6 (1979). Read more (PubMed: 86576) » ... The use of thionin and acridine orange in staining semithin sections of plant material embedded in epoxy resin.. Stain Technol ... Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. ...
The use of acridine orange stained buffy coat smears was assessed as a rapid screening test for bacteremia in adults. A total ... Rapid Diagnosis of Bacteremia in Adults Using Acridine Orange Stained Buffy Coat Smears. Mark Miller1,2 and Jack Mendelson1 ... Compared to blood culture, the overall sensitivity of acridine orange stained buffy coat smears was 16%, specificity 88%, and ... from which a buffy coat smear was prepared and stained with acridine orange (100 mg/L; pH 3.0). Forty-one of 356 blood samples ...
... acridine , C27H15N , CID 186220 - structure, chemical names, physical and chemical properties, classification, patents, ...
Acridine, 1,2,3,4-tetrahydro-, 10-oxide , C13H13NO , CID 168170 - structure, chemical names, physical and chemical properties, ...
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and ... Acridine Diamine, Tetramethyl; Base, Acridine Orange; Diamine, Tetramethyl Acridine; Orange 3RN, Basic; Orange Base, Acridine; ... Acridine Orange. Subscribe to New Research on Acridine Orange A cationic cytochemical stain specific for cell nuclei, ... 3,6-Bis(dimethylamino)acridine; Acridine Orange Base; Basic Orange 3RN; C.I. 46005; C.I. Basic Orange 14; Rhoduline Orange; ...
... Joanne Lannigan joannelannigan at virginia.edu Mon Jun 7 15:20:40 EST 2004 *Previous message: Acridine Orange ... Acridine Orange , , Does anyone routinely run acridine orange through their , FACScan/FACSort? I would like suggestions for ...
... DARZYNKIEWICZ ZBIGNIEW Z_DARZYNKIEWICZ at nymc.edu Mon Jun 7 14:47:50 EST 2004 *Previous message: Parts to ... Acridine Orange Does anyone routinely run acridine orange through their FACScan/FACSort? I would like suggestions for cleaning ... We do routinely use acridine orange using FACScan. A 20 min rinse with 10 times water-diluted Chlorox bleach is adequate to ...
9-acridinecarboxylic acid hydrate, acridine-9-carboxylic acid hydrate, acmc-1afs1, c14h9no2.h2o, acridin-9-carboxylic acid ... 9-acridinecarboxylic acid hydrate, acridine-9-carboxylic acid hydrate, acmc-1afs1, c14h9no2.h2o, acridin-9-carboxylic acid ... 9-acridinecarboxylic acid hydrate, acridine-9-carboxylic acid hydrate, acmc-1afs1, c14h9no2.h2o, acridin-9-carboxylic acid ... hydrate, 9-acridinecarboxylic acid hydrate, acridine-9-carboxylic acid hydrate 1:x. ...
Diagnosis of malaria by acridine orange fluorescent microscopy in an endemic area of venezuela.. Bosch I1, Bracho C, Pérez HA. ... Fluorescent (acridine orange) microscopical examination of capillary centrifuged blood (quantitative buffy coat [QBC] analysis ...
... acridine yellow explanation free. What is acridine yellow? Meaning of acridine yellow medical term. What does acridine yellow ... Looking for online definition of acridine yellow in the Medical Dictionary? ... Acridine yellow , definition of acridine yellow by Medical dictionary https://medical-dictionary.thefreedictionary.com/acridine ... acridine yellow. Also found in: Wikipedia. ac·ri·dine yel·low. (akri-dēn yelō), A faintly yellow solution with strong bluish- ...
Prototropic interactions of pyrimidine nucleic acid bases with acridine: a spectroscopic investigation. Download Prime PubMed ... Photophysical behavior of acridine with amines within the micellar microenvironment of SDS: a time-resolved fluorescence and ... Prototropic interactions of pyrimidine nucleic acid bases with acridine: a spectroscopic investigation.. J Phys Chem B. 2012 ... "Prototropic Interactions of Pyrimidine Nucleic Acid Bases With Acridine: a Spectroscopic Investigation." The Journal of ...
A grade of acridine orange of exceptionally high purity, suitable for quantitative work. Free of inorganic salts. ... Polysciences grade of acridine orange is of exceptionally high purity, suitable for quantitative work. It is free of inorganic ... Acridine orange is a nucleic acid-selective fluorescent cationic dye useful for cell cycle determination. It emits green ... We offer a highly purified form of acridine orange while most of the other commercially available grades are either of low ...
... acridine explanation free. What is acridine? Meaning of acridine medical term. What does acridine mean? ... Looking for online definition of acridine in the Medical Dictionary? ... acridine. Also found in: Dictionary, Encyclopedia, Wikipedia.. Related to acridine: acridine dyes anthracene. [an´thrah-sēn] a ... acridine. /ac·ri·dine/ (ak´rĭ-dēn) an alkaloid from anthracene used in the synthesis of dyes and drugs.. acridine. [ak′ridēn] ...
We have explored a series of trisubstituted acridine-peptide conjugates for their ability to recognize and discriminate between ... Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates† James E. Redman,a J. M. Granadino-Roldán,b ... acridine. -. peptide. conjugates J. E. Redman, J. M. Granadino-Roldán, J. A. Schouten, S. Ladame, A. P. Reszka, S. Neidle and S ... acridine. , and the identity of the C-terminus (acid or amide. ). Surface plasmon resonance. measurements revealed that all ...
5,12-dihydroquinolino[2,3-b]acridine-7,14-dione and (mono and bis)-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-5,12- ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
4,11-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione EC Number:. 221-423-9. EC Name:. 4,11-dichloro-5,12-dihydroquino[2,3- ... 4,11-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dioneacridine-7,14-dioneacridine-7,14-dione
4,11-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione. Regulatory process names 1 CAS names 1 IUPAC names 2 Other ...
By Leo Chan,2018-06-20T20:27:59+00:00May 20th, 2015,Categories: Cellometer Application News,Tags: Acridine Orange, Propidium ...
Patients receive acridine carboxamide IV over 24 hours. for 5 days. Treatment repeats every 3 weeks for a maximum of 6 courses ... OBJECTIVES: I. Determine the effect of acridine carboxamide on objective response, response. rate, and duration of response in ...
  • Acridine yellow, also known as acridine yellow G, acridine yellow H107, basic yellow K, and 3,6-diamino-2,7-dimethylacridine, is a yellow dye with strong bluish-green fluorescence. (wikipedia.org)
  • The fluorescence spectra of acridine oligomers were affected strongly upon binding to DNA. (hindawi.com)
  • Since they are displaced by the float to the easily inspected twenty-nine micron free space surrounding the float, they can be visualized, by placing the centrifuged tube in a notched holder and examining the tube using a 50X oil objective on an epi-illuminating microscope, due to the parasites' uptake of acridine orange and the resultant fluorescence (14) (Figures 2 and 3). (thefreedictionary.com)
  • In this work, we tested the hypothesis that HA-bound sperm would be enhanced in sperm of high DNA chain integrity and green acridine orange fluorescence (AOF) compared with the original sperm in semen. (nih.gov)
  • Zhou, X. Intercalation of herbicide propyzamide into DNA using acridine orange as a fluorescence probe. (alfa.com)
  • This is done during the excitation of Acridine Orange under blue light at pH level of 3.5 while detecting the cells with the help of fluorescence microscope. (alphachemikaindia.com)
  • Reliability of acridine orange fluorescence microscopy in oral cytodiagnosis. (bvsalud.org)
  • The present study was conducted to determine the reliability of acridine orange fluorescence microscopy for cytodiagnosis as a more rapid and easier method for the final evaluation of the cytological specimen. (bvsalud.org)
  • The acridine orange fluorescence stain reliably demonstrated malignant cells based on the differential fluorescence - a cytochemical criterion. (bvsalud.org)
  • However, the acridine orange fluorescence stain did not differentiate effectively between malignant cells and rapidly proliferating cells, as the technique is based on the nucleic acid content. (bvsalud.org)
  • Acridines are substituted derivatives of the parent ring. (wikipedia.org)
  • Acridine and its derivatives can be prepared by many synthetic processes. (wikipedia.org)
  • Acridine and related derivatives (such as amsacrine) bind to DNA and RNA due to their abilities to intercalate. (wikipedia.org)
  • Acridine dyes are prepared by condensation of 1,3-diaminobenzene derivatives. (wikipedia.org)
  • Although the acridine derivatives described in this study are not cytotoxic, they show a clear affinity for several DNA G-quadruplex structures, especially those sequences found in the promoter regions of c-myc [ 16 ] and bcl -2 [ 17 , 18 ] oncogenes. (hindawi.com)
  • Derivatives of acridine are successful as antibacterial agents, finding their principal use as local antiseptics. (thefreedictionary.com)
  • Cancer is a major health problem in the developed and developing Countries.Inspired by the wide range of useful activities possessed by the acridine derivatives and in continuation of our efforts in search of potential anticancer agents, we have synthesized 9-anilinoacridine derivative and 9-anilino-2-methoxy acridine derivatives. (morebooks.de)
  • An effect of acridine derivatives on DNA synthesis raised the hypothesis that acridine moieties secondary effect on biochemical pathways, including protein and lipid metabolism exists, which suggest acridine derivatives could be considered multi targets drugs.Structural modification may lead to synthesize more acridine derivatives. (morebooks.de)
  • We have synthesized acridine orange derivatives which comprise an imidazole-2-carbaldehyde function for coordination to the Re(CO)(3)](+) or (99)mTc(CO)(3)](+) core. (uzh.ch)
  • acridine dyes heterocyclic compounds that in- clude acridine (shown below) and its derivatives. (damasgate.com)
  • Acridine is a raw material used for the production of dyes and some valuable drugs and its derivatives have antiseptic properties like Proflavine. (ac.ir)
  • Several similarly substituted benz[a]acridine and benz[c]acridine derivatives were synthesized and their relative activity as topoisomerase poisons was determined. (elsevier.com)
  • In comparison to coralyne or other protoberberine derivatives, these benz[a]acridine derivatives possess distinctly different physicochemical properties and represent a novel series of topo I poisons. (elsevier.com)
  • In the Bernthsen acridine synthesis, diphenylamine is condensed with carboxylic acids in the presence of zinc chloride. (wikipedia.org)
  • Other older methods for the organic synthesis of acridines include condensing diphenylamine with chloroform in the presence of aluminium chloride, by passing the vapours of orthoaminodiphenylmethane over heated litharge, by heating salicylaldehyde with aniline and zinc chloride or by distilling acridone (9-position a carbonyl group) over zinc dust. (wikipedia.org)
  • The synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase methodology is described. (hindawi.com)
  • Here we described solid-phase synthesis protocols for the preparation of several acridine oligomers linked through 2-aminoethylglycine units as well as their DNA-binding properties. (hindawi.com)
  • 2,7-Bis(alloxycarbonylamino)-9-(biotinylaminoethylamino)acridine (cas# 1219125-65-1) is a compound useful in organic synthesis. (trc-canada.com)
  • An interesting such application is the use of acridine-labeled primers to study non-enzymatic-template-directed RNA synthesis to provide experimental support for theories concerning possible replication of genetic information by early life forms on Earth (5). (genelink.com)
  • Acridine carboxamide ( N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide ) is an chemotherapy agent that is being studied in the treatment of cancer . (bionity.com)
  • It uses material from the Wikipedia article "Acridine_carboxamide" . (bionity.com)
  • OBJECTIVES: I. Determine the effect of acridine carboxamide on objective response, response rate, and duration of response in patients with unresectable, locally advanced, progressive or metastatic non-small cell lung cancer. (knowcancer.com)
  • Patients receive acridine carboxamide IV over 24 hours for 5 days. (knowcancer.com)
  • Metabolism of the experimental antitumor agent acridine carboxamide in the mouse. (aspetjournals.org)
  • The metabolism of the experimental antitumor agent acridine carboxamide (AC) has been examined in the male BDF1 mouse. (aspetjournals.org)
  • After 24h, cells were stained using acridine orange dye. (nih.gov)
  • The use of thionin and acridine orange in staining semithin sections of plant material embedded in epoxy resin. (abcam.com)
  • We have tried thionin and acridine orange stains and found it to be good as it showed good colour contrast between mast cells and the background tissue. (who.int)
  • Acridine orange (3,6-dimethylaminoacridine) is a nucleic acid-selective metachromatic stain useful for cell cycle determination. (wikipedia.org)
  • Application: Acridine orange has been used as a fluorescent stain for nucleic acids in agarose and polyacrylamide gels. (bio-medicine.org)
  • The sensitivity of Gram stain (GS) was 98.26% while Acridine Orange (AO) stain proved to be more sensitive (100%) with a Positive and Negative Predictive Value of 100% each. (deepdyve.com)
  • IMSEAR at SEARO: A modified thionin acridine-orange stain for mast cells. (who.int)
  • One smear was stained with Papanicolaou stain and another one with acridine orange stain. (bvsalud.org)
  • In this work, we present efforts towards designing and synthesizing acridine-based macrocycles (Mh) and (Mb) with the purpose of providing potential G4 ligands that are suited for selective binding to G4 vs. duplex DNA, and stabilize G-quadruplex structures. (queensu.ca)
  • Several dyes and drugs feature the acridine skeleton. (wikipedia.org)
  • Among the acridine compounds, 3,6,9-trisubstituted acridines have inhibitory activity in the nanomolar range and they have entered preclinical studies [ 8 , 10 , 11 ]. (hindawi.com)
  • Benz[ a ]acridine is present as a minor component of the total content of polynuclear aromatic compounds in the environment. (inchem.org)
  • These results indicate that acridine and dinitroaniline herbicides with the plant extracts are promising lead compounds for development as novel antileishmanial agents. (thefreedictionary.com)
  • The highest degrees of selectivity were observed towards the N-ras quadruplex by compounds capable of forming simultaneous contacts with their acridine and peptide moieties. (rsc.org)
  • To further investigate their antiproliferative activities, we have assessed the antiproliferative activity of these acridine-based compounds against several pancreatic cancer cell lines. (umn.edu)
  • In light of the potential importance of the anticancer activity of these acridine-based compounds, we have conducted a series of biochemical assays to determine the effect of these compounds on human topoisomerase II. (umn.edu)
  • Thus, these novel acridine-based compounds with anti-pancreatic cancer activity are catalytic inhibitors, not poisons, of human topoisomerase II. (umn.edu)
  • Many acridines, such as proflavine, also have antiseptic properties. (wikipedia.org)
  • We have explored a series of trisubstituted acridine - peptide conjugates for their ability to recognize and discriminate between DNA quadruplexes derived from the human telomere, and the c-kit and N-ras proto-oncogenes. (rsc.org)
  • Amino acid or peptide conjugates of acridine/acridone and quinoline/quinolone-containing drugs. (nature.com)
  • The use of acridine orange stained buffy coat smears was assessed as a rapid screening test for bacteremia in adults. (hindawi.com)
  • Direct staining of blood smears with acridine orange and enumeration using fluorescent microscopy allowed quantitation of Haemophilus influenzae in blood at densities from 10(5) to 10(8) cfu/ml. (curehunter.com)
  • Fluorescent (acridine orange) microscopical examination of capillary centrifuged blood (quantitative buffy coat [QBC] analysis) and Giemsa stained thick blood smears (GTS) were compared for diagnosis of malaria in blood specimens from adults living in malaria transmission areas of the States of Bolivar and Amazonas in southeastern and south Venezuela, respectively. (nih.gov)
  • Comparison of the automicrobic system, acridine orange-stained smears, and gram-stained smears in detecting bacteriuria. (asm.org)
  • Benz[ a ]acridine was inadequately tested for carcinogenicity in one experiment by skin application to mice. (inchem.org)
  • The single report of the mutagenicity of benz[ a ]acridine in Salmonella typhimurium was inconclusive. (inchem.org)
  • There is inadequate evidence that benz[ a ]acridine is active in short-term tests. (inchem.org)
  • Human exposure to benz[ a ]acridine occurs primarily through inhalation of polluted air and by ingestion of food and water contaminated with combustion products. (inchem.org)
  • The available data are inadequate to permit the evaluation of the carcinogenicity of benz[ a ]acridine in experimental animals. (inchem.org)
  • Among the benz[a]acridines studied, 5,6-dihydro-3,4- methylenedioxy-9,10-dimethoxybenz[a]acridine, 13e, was the most potent topo I poison, with comparable potency to coralyne. (elsevier.com)
  • Polysciences' grade of acridine orange is of exceptionally high purity, suitable for quantitative work. (polysciences.com)
  • We offer a highly purified form of acridine orange while most of the other commercially available grades are either of low purity or in zinc chloride complex form. (polysciences.com)
  • Acridine orange/ethidium bromide (AO/EtBr) and Hoechst 33342 were obtained from Fluka (Ronkonkoma, NY, USA). (thefreedictionary.com)
  • Diagnosis of malaria by acridine orange fluorescent microscopy in an endemic area of venezuela. (nih.gov)
  • Two ligands described in this study include an acridine core which provides an aromatic surface capable of π-π interactions with the surface of G-quadruplexes. (queensu.ca)
  • Like the related molecules pyridine and quinoline, acridine is mildly basic. (wikipedia.org)
  • The effect of varicocele on sperm morphology and DNA maturity: does acridine orange staining facilitate diagnosis? (thefreedictionary.com)
  • Acridine orange staining is a methodology for nucleic acid selective metachromatic staining that is useful for following cell cycle determination. (unomaha.edu)
  • Mycobacterium tuberculosis in a sputum smear is stained using fluorescent auramine with acridine orange counterstain. (polysciences.com)
  • For 1,024 clinical specimens, results with the acridine orange-stained smear and the Gram-stained smear were very similar. (asm.org)
  • Acridine yellow damages DNA and is used as a mutagen in microbiology. (wikipedia.org)
  • We do routinely use acridine orange using FACScan. (purdue.edu)
  • creswelk at georgetown.edu ] Sent: Friday, June 04, 2004 1:17 PM To: cyto-inbox Subject: Acridine Orange Does anyone routinely run acridine orange through their FACScan/FACSort? (purdue.edu)
  • Acridine orange is a nucleic acid-selective fluorescent cationic dye useful for cell cycle determination. (polysciences.com)
  • Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. (wikipedia.org)
  • Labeling of DNA oligos with acridine allows them to rapidly and stably intercalate into a target dsDNA molecule, adding increased stability to the double helix (1). (genelink.com)
  • By using the process of condensation, Acridine dyes can be prepared by condensing 1,3-diaminobenzene and allied benzaldehydes. (alphachemikaindia.com)
  • Giemsa staining, acridine orange (AO) staining and semi-nested multiplex PCR. (curehunter.com)
  • The present study compares the value of the Acridine Orange technique and the Giemsa staining technique for the detection of Dipetalonema perstans in blood films. (journals.co.za)
  • The study revealed that the Acridine technique was at least as sensitive as the older Giemsa technique, but proved quicker and less tiring to use. (journals.co.za)
  • Acridine is a photobase which has a ground state pKa of 5.1, similar to that of pyridine, and an excited state pKa of 10.6. (wikipedia.org)
  • Cell viability was measured by MTS assay and apoptosis was assessed by Annexin V/PI and acridine orange staining. (nih.gov)
  • Acridine orange staining was used to visualize apoptosis in A172 (A) and U87 (B). Cells were treated with 0, 10 or 100 ng/ml rhTRAIL WT and 0, 25 or 50 μM DMC. (nih.gov)
  • Vital staining with the dye, acridine orange, has been previously used to analyze patterns of apoptosis in both vertebrate and invertebrate embryos (3,4). (alpfmedical.info)
  • During apoptosis, cells fragment into a number of apoptotic bodies that are chromatin-rich and are intensely stained by acridine orange. (alpfmedical.info)
  • Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. (abcam.com)
  • At least for ex vivo biopsy analysis, however, using exogenous nuclear stains, such as acridine orange, could largely circumvent this problem. (thefreedictionary.com)
  • The interaction of acridine orange with target molecules (i.e. (unomaha.edu)
  • Acridine orange at a concentration of 120 μM will detect purified DNA in gels with a sensitivity of 25-50 ng per band. (bio-medicine.org)