Acridine Orange
Aminoacridines
Intercalating Agents
Aminacrine
Staining and Labeling
Nitracrine
Ethidium
A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
Quinacrine
Fluorescent Dyes
Amsacrine
Azure Stains
Acridones
Chlorophyllides
Gentian Violet
Mutagens
Mustard Compounds
Strong alkylating and immunosuppressive agents whose biological activity is based on the presence of bis(2-chloroethyl)- groups. Although otherwise structurally diverse, the compounds have in common the capacity to contribute alkyl groups to DNA. They are generally highly toxic but include among their number many widely used and effective antineoplastic agents.
Tetrahydroisoquinolines
Microscopy, Fluorescence
Benzophenoneidum
Coloring Agents
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Cardiolipins
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.
Antimutagenic Agents
Lysosomes
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Hydrogen-Ion Concentration
Nitrogen Mustard Compounds
Nucleic Acid Denaturation
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Characterization of nuclear structures containing superhelical DNA. (1/786)
Structures resembling nuclei but depleted of protein may be released by gently lysing cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids sediment in gradients containing intercalating agents in a manner characteristic of DNA that is intact, supercoiled and circular. The concentration of salt present during isolation of human nucleoids affects their protein content. When made in I-95 M NaCl they lack histones and most of the proteins characteristic of chromatin; in 1-0 M NaCl they contain variable amounts of histones. The effects of various treatments on nucleoid integrity were investigated. (+info)Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. (2/786)
Class I P-glycoproteins (Pgp) confer multidrug resistance in tumors, but the physiologic function of Pgp in normal tissues remains uncertain. In cells derived from tissues that normally express Pgp, recent data suggest a possible role for Pgp in cholesterol trafficking from the plasma membrane to the endoplasmic reticulum. We investigated the esterification of plasma membrane cholesterol under basal conditions and in response to sphingomyelinase treatment in transfected and drug-selected cell lines expressing differing amounts of functional class I Pgp. Compared with parental NIH 3T3 fibroblasts, cells transfected with human multidrug resistance (MDR1) Pgp esterified more cholesterol both without and with sphingomyelinase. Esterification also was greater in drug-selected Dox 6 myeloma cells than parental 8226 cells, which express low and non-immunodetectable amounts of Pgp, respectively. However, no differences in total plasma membrane cholesterol were detected. Transfection of fibroblasts with the multidrug resistance-associated protein (MRP) did not alter esterification, showing that cholesterol trafficking was not generally affected by ATP-binding cassette transporters. Steroidal (progesterone, dehydroepiandrosterone) and non-steroidal antagonists (verapamil, PSC 833, LY335979, and GF120918) were evaluated for effects on both cholesterol trafficking and the net content of 99mTc-Sestamibi, a reporter of drug transport activity mediated by Pgp. In Pgp-expressing cells treated with nonselective and selective inhibitors, both the kinetics and efficacy of inhibition of cholesterol esterification differed from the antagonism of drug transport mediated by Pgp. Thus, although the data show that greater expression of class I Pgp within a given cell type is associated with enhanced esterification of plasma membrane cholesterol in support of a physiologic function for Pgp in facilitating cholesterol trafficking, the molecular mechanism is dissociated from the conventional drug transport activity of Pgp. (+info)Serum sErbB1 and epidermal growth factor levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. (3/786)
Epithelial ovarian cancer (EOC) has a high mortality rate, which is due primarily to the fact that early clinical symptoms are vague and nonspecific; hence, this disease often goes undetected and untreated until in its advanced stages. Sensitive and reliable methods for detecting earlier stages of EOC are, therefore, urgently needed. Epidermal growth factor (EGF) is a ligand for EGF receptor (ErbB1); this receptor is the product of the c-erbB1 proto-oncogene. ErbB1 overexpression is common in human ovarian carcinoma-derived cell lines and tumors, in which overexpression is thought to play a critical role in tumor etiology and progression. Furthermore, ErbB1 overexpression is associated with disease recurrence and decreased patient survival. Recently, we have developed an acridinium-linked immunosorbent assay that detects a approximately 110-kDa soluble analogue of ErbB1, ie., sErbB1, in serum samples from healthy men and women (A. T. Baron, et al., J. Immunol. Methods, 219: 23-43, 1998). Here, we demonstrate that serum p110 sErbB1 levels are significantly lower in EOC patients with stage III or IV disease prior to (P < 0.0001) and shortly after (P < 0.0001) cytoreductive staging laparotomy than in healthy women of similar ages, whereas EGF levels are significantly higher than those of age-matched healthy women only in serum samples collected shortly after tumor debulking surgery (P < 0.0001). We observe that the preoperative serum sErbB1 concentration range of advanced stage EOC patients barely overlaps with the serum sErbB1 concentration range of healthy women. In addition, we show that serum sErbB1 and EGF levels changed temporally for some EOC patients who were surgically debulked of tumor and who provided a second serum sample during the course of combination chemotherapy. Finally, we observe a significant positive association between sErbB1 and EGF levels only in serum samples of EOC patients collected prior to cytoreductive surgery (correlation coefficient = 0.61968; P = 0.0027). These data suggest that epithelial ovarian tumors concomitantly affect serum sErbB1 and EGF levels. In conclusion, these data indicate that serum sErbB1 and EGF (postoperative only) levels are significantly different between EOC patients and healthy women and that altered and/or changing serum sErbB1 and EGF levels may provide important diagnostic and/or prognostic information useful for the management of patients with EOC. (+info)Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918. (4/786)
The acridone carboxamide derivative GG918 (N-{4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-pheny l}-9,10dihydro-5-methoxy-9-oxo-4-acridine carboxamide) is a potent inhibitor of MDR1 P-glycoprotein-mediated multidrug resistance. Direct measurements of ATP-dependent MDR1 P-glycoprotein-mediated transport in plasma membrane vesicles from human and rat hepatocyte canalicular membranes indicated 50% inhibition at GG918 concentrations between 8 nM and 80 nM using N-pentyl-[3H]quinidinium, ['4C]doxorubicin and [3H]daunorubicin as substrates. The inhibition constant K for GG918 was 35 nM in rat hepatocyte canalicular membrane vesicles with [3H]daunorubicin as the substrate. Photoaffinity labelling of canalicular and recombinant rat Mdr1b P-glycoprotein by [3H]azidopine was suppressed by 10 muM and 40 muM GG918. The high selectivity of GG918-induced inhibition was demonstrated in canalicular membrane vesicles and by analysis of the hepatobiliary elimination in rats using [3H]daunorubicin, [3H]taurocholate and [3H]cysteinyl leukotrienes as substrates for three distinct ATP-dependent export pumps. Almost complete inhibition of [3H]daunorubicin transport was observed at GG918 concentrations that did not affect the other hepatocyte canalicular export pumps. The high potency and selectivity of GG918 for the inhibition of human MDR1 and rat Mdr1b P-glycoprotein may serve to interfere with this type of multidrug resistance and provides a tool for studies on the function of these ATP-dependent transport proteins. (+info)A method for the deductive and unique determination of the values of three parameters involved in fractional functions applicable to relaxation kinetics. (5/786)
A novel method is proposed to determine deductively and uniquely the values of three parameters, a, b, and c in a fractional function of the form, y=a+bx/(c+x) where x and y are experimentally obtainable variables. This type of equation is frequently encountered in chemistry and biochemistry involving relaxation kinetics. The method of least squares with the Taylor expansion is employed for direct curve fitting of observed data to the fractional function. Approximate values of the parameters, which are always necessary prior to commending the above procedure, can be obtained by the method of rearrangement after canceling the denominator of fractional functions. This procedure is very simple, but very effective for estimating provisional values of the parameters. Deductive and unique determination of the parameters involved in the fractional function shown above can be accomplished for the first time by the combination of these two procedures. This method is extended to include the analysis of relaxation kinetic data such as those of temperature-jump method where the determination of equilibrium concentrations of reactants in addition to the three parameters is also necessary. (+info)Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. (6/786)
BACKGROUND: Angiotensin II activates NAD(P)H-dependent oxidases via AT1-receptor stimulation, the most important vascular source of superoxide (O2*-). The AT1 receptor is upregulated in vitro by low-density lipoprotein. The present study was designed to test whether hypercholesterolemia is associated with increased NAD(P)H-dependent vascular O2*- production and whether AT1-receptor blockade may inhibit this oxidase and in parallel improve endothelial dysfunction. METHODS AND RESULTS: Vascular responses were determined by isometric tension studies, and relative rates of vascular O2*- production were determined by use of chemiluminescence with lucigenin, a cypridina luciferin analogue, and electron spin resonance studies. AT1-receptor mRNA was quantified by Northern analysis, and AT1-receptor density was measured by radioligand binding assays. Hypercholesterolemia was associated with impaired endothelium-dependent vasodilation and increased O2*- production in intact vessels. In vessel homogenates, we found a significant activation of NADH-driven O2*- production in both models of hyperlipidemia. Treatment of cholesterol-fed animals with the AT1-receptor antagonist Bay 10-6734 improved endothelial dysfunction, normalized vascular O2*- and NADH-oxidase activity, decreased macrophage infiltration, and reduced early plaque formation. In the setting of hypercholesterolemia, the aortic AT1 receptor mRNA was upregulated to 166+/-11%, accompanied by a comparable increase in AT1-receptor density. CONCLUSIONS: Hypercholesterolemia is associated with AT1-receptor upregulation, endothelial dysfunction, and increased NADH-dependent vascular O2*- production. The improvement of endothelial dysfunction, inhibition of the oxidase, and reduction of early plaque formation by an AT1-receptor antagonist suggests a crucial role of angiotensin II-mediated O2*- production in the early stage of atherosclerosis. (+info)Paracrine role of adventitial superoxide anion in mediating spontaneous tone of the isolated rat aorta in angiotensin II-induced hypertension. (7/786)
The relationship between vascular generation of superoxide anion and spontaneous tone observed in the isolated aorta was studied in hypertensive rats infused with angiotensin II. Aortic rings from hypertensive, but not from sham-operated rats, demonstrated oscillatory spontaneous tone that represented 52+/-5.6% of the maximal contraction to KCl. Spontaneous tone was prevented by calcium-free buffer or by blocking calcium influx through L-type calcium channels with nifedipine. The production of superoxide anion measured by lucigenin chemiluminescence was up to 15-fold higher than in sham-operated rat aorta. The adventitial site of production of superoxide anion was suggested by the fact that lucigenin chemiluminescence was 5.5-fold higher from the adventitia than from the intima. This was confirmed histochemically by demonstrating that the adventitia was the site of reduction of nitroblue tetrazolium as well as immunohistochemical staining of NAD(P)H oxidase subunit proteins. A causal link between superoxide anion production by NAD(P)H oxidase and the spontaneous tone is suggested by the fact that superoxide dismutase or the inhibitor of NAD(P)H oxidase, diphenylene iodonium, decreased both superoxide anion production and spontaneous tone. L-NAME or removal of the endothelium from the aorta had no significant effect on superoxide anion levels or spontaneous tone. However, although superoxide dismutase decreased superoxide anion levels in the presence of L-NAME or in endothelium-denuded rings, it no longer inhibited the tone. This suggests that the effect on tone of superoxide anion originating in the adventitia is mediated by inactivating endothelium-derived nitric oxide, which promotes smooth muscle calcium influx and spontaneous tone. The adventitia is not a passive bystander during the development of hypertension, but rather it may have an important role in the regulation of smooth muscle tone. (+info)Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation. (8/786)
Lucigenin-amplified chemiluminescence has frequently been used to assess the formation of superoxide in vascular tissues. However, the ability of lucigenin to undergo redox cycling in purified enzyme-substrate mixtures has raised questions concerning the use of lucigenin as an appropriate probe for the measurement of superoxide production. Addition of lucigenin to reaction mixtures of xanthine oxidase plus NADH resulted in increased oxygen consumption, as well as superoxide dismutase-inhibitable reduction of cytochrome c, indicative of enhanced rates of superoxide formation. Additionally, it was revealed that lucigenin stimulated oxidant formation by both cultured bovine aortic endothelial cells and isolated rings from rat aorta. Lucigenin treatment resulted in enhanced hydrogen peroxide release from endothelial cells, whereas exposure to lucigenin resulted in inhibition of endothelium-dependent relaxation in isolated aortic rings that was superoxide dismutase inhibitable. In contrast, the chemiluminescent probe coelenterazine had no significant effect on xanthine oxidase-dependent oxygen consumption, endothelial cell hydrogen peroxide release, or endothelium-dependent relaxation. Study of enzyme and vascular systems indicated that coelenterazine chemiluminescence is a sensitive marker for detecting both superoxide and peroxynitrite. (+info)
Acridine dye synonyms, acridine dye antonyms - FreeThesaurus.com
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Pyrazoloacridine in Treating Patients With Metastatic Skin or Eye Melanoma - Full Text View - ClinicalTrials.gov
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Cas 118474-59-2,10-{3-[(2-aminoethyl)amino]propyl}-3,6-bis(dimethylamino)acridinium platinum(2+) chloride (1:1:3) | lookchem
4-[(5-{[5-(2,4-Dichlorophenyl)-3,4-dihydro-2(1H)-isoquinolinyl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile | C27H22Cl2N4 |...
Acridinium | Organic Chemicals | Spectrum Chemical
E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phenyl}-6-pyridin-3-yl-hex-5-enoic acid amide | C25H26ClN3O3S - PubChem
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acridine 260-94-6 MSDS, Safety Technical Specifications MSDS
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Acridine Orange
Summary Report | CureHunter
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ChemIDplus - 17784-47-3 - XUESTGHCVFYOLL-UHFFFAOYSA-N - Acridine, hydrochloride - Similar structures search, synonyms, formulas...
Basic Orange 14
Synthesis, characterization and biological evaluation of six highly cytotoxic ruthenium(ii) complexes with 4′-substituted-2,2′...
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Acridine Orange
Boronic acid, B-[4-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]phenyl]-,Boronic acid, B-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-...
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Acridine
... is easily oxidized by peroxymonosulfuric acid to the acridine amine oxide. The carbon 9-position of acridine is ... biologically active acridines, applications of acridines, new syntheses and reactions of acridines] Wikisource has original ... Acridine and its homologues are weakly basic. Acridine is a photobase which has a ground state pKa of 5.1, similar to that of ... Acridine and related derivatives (such as amsacrine) bind to DNA and RNA due to their abilities to intercalate. Acridine orange ...
Acridine yellow
... damages DNA and is used as a mutagen in microbiology. Acridine yellow is similar to acridine orange. According ... Acridine yellow, also known as acridine yellow G, acridine yellow H107, basic yellow K, and 3,6-diamino-2,7-dimethylacridine, ... It is a derivate of acridine. In histology, it is used as a fluorescent stain, and as a fluorescent probe for non-invasive ... Acridine yellow absorption and emission spectra v t e (Articles needing additional references from July 2021, All articles ...
Acridine orange
... is derived from the organic molecule acridine, which was first discovered by Carl Grabe and Heinrich Caro, who ... Acridine orange and fluorescein have a maximum excitation at 502nm and 525 nm (green). When acridine orange associates with RNA ... Acridine orange is useful in the rapid screening of ordinarily sterile specimens. When acridine orange is used with flow ... Acridine dyes are prepared via the condensation of 1,3-diaminobenzene with suitable benzaldehydes. Acridine orange is derived ...
Acridine carboxamide
... is a chemotherapy agent that is being studied in the treatment of cancer. It belongs to the family of ... Ondansetron, an isomer of Acridine carboxamide Dittrich C, Dieras V, Kerbrat P, Punt C, Sorio R, Caponigro F, et al. (August ... Acridines, All stub articles, Antineoplastic and immunomodulating drug stubs). ...
Bernthsen acridine synthesis
The Bernthsen acridine synthesis is the chemical reaction of a diarylamine heated with a carboxylic acid (or acid anhydride) ... The use of polyphosphoric acid will give acridine products at a lower temperature, but also with decreased yields. Bernthsen, A ... and zinc chloride to form a 9-substituted acridine. Using zinc chloride, one must heat the reaction to 200-270 °C for 24hrs. ...
DNA
Ferguson LR, Denny WA (September 1991). "The genetic toxicology of acridines". Mutation Research. 258 (2): 123-60. doi:10.1016/ ... Most intercalators are aromatic and planar molecules; examples include ethidium bromide, acridines, daunomycin, and doxorubicin ...
August Bernthsen
Bernthsen, August (1884). "Die Acridine". Justus Liebig's Annalen der Chemie (in German). 224 (1-2): 1-56. doi:10.1002/jlac. ... Synthese der Acridine". Berichte der Deutschen Chemischen Gesellschaft (in German). 16 (2): 1802-1819. doi:10.1002/cber. ...
Graham Cairns-Smith
Cairns Smith, A. G. (1957). "Studies in the acridine series". {{cite journal}}: Cite journal requires ,journal= (help) Dennett ...
Acriflavine
It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial ...
Proflavine
Denny (2002). "Acridine Derivatives as Chemotherapeutic Agents". Current Medicinal Chemistry. 9 (18): 1655-65. doi:10.2174/ ... Gatasheh, Mansour K; Kannan, S; Hemalatha, K; Imrana, N (2017). "Proflavine an acridine DNA intercalating agent and strong ... Acridines, DNA intercalaters, All stub articles, Molecular and cellular biology stubs). ...
Chlorophyllin
... also binds to acridine orange. Chlorophyllin has been validated to exhibit ameliorative effects against food ...
Phenanthridine
Acridine is an isomer of phenanthridine. Phenanthridine was discovered by Amé Pictet and H. J. Ankersmit in 1891 by pyrolysis ...
Base pair
Examples include ethidium bromide and acridine.[citation needed] Mismatched base pairs can be generated by errors of DNA ...
Leonard Lerman
Lerman, L. S. (1963). "The structure of the DNA-acridine complex". Proc. Natl. Acad. Sci. USA. 49 (1): 94-102. Bibcode:1963PNAS ... Lerman, L. S. (1961). "Structural considerations in the interactions of deoxyribonucleic acid and acridines". Journal of ...
Intercalation (biochemistry)
Lerman, L. S. (1963). "The structure of the DNA-acridine complex". Proceedings of the National Academy of Sciences of the ... Lerman, L. S. (1961). "Structural considerations in the interaction of DNA and acridines" (PDF). Journal of Molecular Biology. ... 9 epoxide of aflatoxin B1 and acridines such as proflavine or quinacrine. Intercalation as a mechanism of interaction between ...
Arene substitution pattern
It is observed in compounds such as calixarenes and acridines. Peri-substitution occurs in naphthalenes for substituents at the ...
Decarboxylative cross-coupling
Derivatives are formed in moderate to good yield; acridine is essential for high reaction efficiency. Jiao et al. enabled the ...
Carl Hamilton Browning
He discovered the therapeutic qualities of acridine dyes. He was born on 21 May 1881 the son of Friederike Sophia Pauline (née ...
Fluorophore
Acridine derivatives: proflavin, acridine orange, acridine yellow, etc. Arylmethine derivatives: auramine, crystal violet, ...
Twisted intercalating nucleic acid
"Synthesis of Twisted Intercalating Nucleic Acids Possessing Acridine Derivatives. Thermal Stability Studies". Bioconjugate ...
Metachromasia
Darzynkiewicz Z, Kapuscinski J. (1990)"Acridine Orange, a Versatile Probe of Nucleic Acids and Other Cell Constituents." ... Another example of metachromatic dye (fluorochrome) is acridine orange. Under certain conditions it stains single-stranded ...
Benzaldehyde
... is also a precursor to certain acridine dyes. Via aldol condensations, benzaldehyde is converted into derivatives ...
Vital stain
Hathaway WE, Newby LA, Githens JH (1964). "The Acridine Orange Viability Test Applied to Bone Marrow Cells. I. Correlation with ...
Adelheid Kofler
Polymorphism of organic substances: acridine, catechol, diphenylamine and suberic acid) -- (1943). "Mikro-Thermoanalyse ...
Polymorphism (materials science)
Acridine has been obtained as eight polymorphs and aripiprazole has nine. The record for the largest number of well- ... Acridine Solid Form Landscape: Eight Polymorphs and a Hydrate" (PDF). Crystal Growth & Design. 19 (8): 4884-4893. doi:10.1021/ ...
Eva Hevia
"Zincate-Mediated Arylation Reactions of Acridine: Pre- and Postarylation Structural Insights" (PDF). Organometallics. 34 (11): ...
Oleocanthal
Cell apoptosis is tested by treating the lysosomal membrane with acridine orange. Acridine orange radiates a red fluorescent ...
Lysosome
Traganos F, Darzynkiewicz Z (1994). "Lysosomal proton pump activity: supravital cell staining with acridine orange ...
Sidney Altman
His project was a study of the effects of acridines on the replication of bacteriophage T4 DNA. He received his Ph.D. in ...
Boranylium ions
Clark, Ewan R.; Ingleson, Michael J. (2013-11-25). "[(acridine)BCl2]+: A Borenium Cation That Is a Strong Boron- and Carbon- ...
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Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: Elucidation of their molecular...
Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: Elucidation of their molecular ... Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: Elucidation of their molecular ... Home / KnowledgeBase Articles / Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: ... The molecular interaction between hemoglobin (HHb), the major human heme protein, and the acridine dyes acridine orange (AO) ...
2-ethyl-6-methyl-phenyl)carbamoylmethyl (4E)-4-[(4-methoxyphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylate
SERS Detection of Dopamine Using Label-Free Acridine Red as Molecular Probe in Reduced Graphene Oxide/Silver Nanotriangle Sol...
where to buy Acridines
We also provide custom synthesis and GMP manufacturing services.where to buy Acridines ... where to buy Acridines, Chemenu is research-based manufacturer of pharmaceutical intermediates and fine chemicals offering ... Acridines. Acridines are organic compounds and nitrogen heterocycles having the formula C13H9N. Acridine is a substituted ... Acridine and its derivatives can be used to make dyes and also used in the pharmaceutical industry. Acridine is a DNA ...
Word Definition - ACRIDINES | Scrabble Solver
IMSEAR at SEARO: Detection of Plasmodia in acridine orange stained capillary tubes (the QBC system).
Pornsilapatip J, Namsiripongpun V, Wilde H, Hanvanich M, Chutivongse S. Detection of Plasmodia in acridine orange stained ... The sensitivity, specificity and convenience of carrying out malaria diagnosis in acridine orange stained capillary tubes using ... Detection of Plasmodia in acridine orange stained capillary tubes (the QBC system).. ...
Publisher: National Academy of Sciences (U.S.) / Story Section: The Institute for Muscle Research, 1947-1972 - Albert Szent...
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Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different...
Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different ... Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different ... Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different ... The fluorescent dye 10-N-nonyl acridine orange (NAO) is extensively used for location and quantitative assays of cardiolipin in ...
Neomycin-Acridine Conjugate Binds RNA
... neo-acridine) was synthesized by covalently linking neomycin B to 9-aminoacridine via a short spacer. ... Neomycin-acridine conjugate (neo-acridine) was synthesized by covalently linking neomycin B to 9-aminoacridine via a short ... of 1.5 nM and effectively disrupts the Rev-RRE complex. The affinity of neo-acridine to the RRE is only 2-fold lower than that ... It appears that neo-acridine is the strongest competitive inhibitor of Rev-RRE binding. It binds the RRE with an inhibition ...
Polycyclic Aromatic Hydrocarbons (PAHs): What Are Polycyclic Aromatic Hydrocarbons (PAHs)? | Environmental Medicine | ATSDR
ArboCat Virus: Kununurra (KNAV)
Interaction of Bioactive Pyrazolo[4,3-a]acridines with Human Serum Albumin
The results show that pyrazolo[4,3-a]acridines with R=propyl, butyl, isobutyl and R=chlorine substituents have suitable ... 11] Marjani A.P., Khalafy J., Chitan M., Mahmoodi S., Microwave-Assisted Synthesis of Acridine-1,8(2h,5h)-diones via a One-Pot ... 16] Goodell J.R., Madhok A.A., Hiasa H., Ferguson D.M., Synthesis and Evaluation of Acridine-and Acridone-Based Anti-Herpes ... The results show that pyrazolo[4,3-a]acridines with R=propyl, butyl, isobutyl and R=chlorine substituents have suitable ...
Acridine Orange Zncl2 Manufacturer, Supplier From Mumbai, Maharashtra - Latest Price
Manufacturer, supplier, Trader and wholesaler of Acridine Orange Zncl2 offered by ARNISH LABORATES PRIVATE LIMITED. at latest ... ACRIDINE ORANGE ZNCL2. As one of the trusted manufacturer, exporter and supplier of allied domain, we have been engaged in ... Moreover, our clients can purchase this ACRIDINE ORANGE ZNCL2 negotiable prices from us. ... providing our clients with excellent quality ACRIDINE ORANGE ZNCL2. This chemical is widely used in processing of xylenlol ...
Anti-Mycobacterial and Synergistic Activity of Synthetic Acridine-9-Carboraldehyde and 9-Hydroxy-4-Methoxy Acridine Alkaloids...
Anti-Mycobacterial and Synergistic Activity of Synthetic Acridine-9-Carboraldehyde and 9-Hydroxy-4-Methoxy Acridine Alkaloids ... Two synthetic acridine alkaloids ie 9-hydroxy-4-methoxy acridine (fig 1) (101760-sv) and acridine-9-carboraldehyde (Fig 2) (# ... acridine 9 carboradehyde and (iv) levofloxacin/ acridine 9 carboradehyde on the rifampicin resistant isolate; (v) acridine 9 ... In this study, acridine-9-carboraldehyde, a synthetic acridine alkaloid was active against the clinical susceptible TB isolates ...
Cells | Free Full-Text | Overexpression of the Selective Autophagy Cargo Receptor NBR1 Modifies Plant Response to Sulfur Deficit
Seedlings From -S Have More Acridine Orange-Stained Red Spots. Acridine Orange (AO) is a membrane-penetrable fluorescent dye ... Acridine orange (AO) staining of the roots of plants grown in -S in the presence and absence of Torin1. ... Figure 2. Comparison of the roots stained with acridine orange (AO). (A) Sulfur starvation increases the number of acidic ... Figure 2. Comparison of the roots stained with acridine orange (AO). (A) Sulfur starvation increases the number of acidic ...
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Sentinel-based Surveillance of Coyotes to Detect Bovine Tuberculosis, Michigan - Volume 14, Number 12-December 2008 - Emerging...
Bioinformatics Prediction and Experimental Verification Identify MAD2L1 and CCNB2 as Diagnostic Biomarkers of Rhabdomyosarcoma ...
meis1 regulates cyclin D1 and c-mycexpression, and controls the proliferation of the multipotent cells in the early developing...
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Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.
... Villa V;Tonelli M; ... All acridine derivatives analyzed showed high affinity binding for hPrP90-231, but only Q3 and Q10, caused a significant ... All acridine derivatives analyzed showed high affinity binding for hPrP90-231, but only Q3 and Q10, caused a significant ... To identify novel derivatives with higher neuroprotective activity, we evaluated the effects of a small library of acridine ...
Orange10
- The molecular interaction between hemoglobin (HHb), the major human heme protein, and the acridine dyes acridine orange (AO) and 9-aminoacridine (9AA) was studied by various spectroscopic, calorimetric and molecular modeling techniques. (jascoinc.com)
- IMSEAR at SEARO: Detection of Plasmodia in acridine orange stained capillary tubes (the QBC system). (who.int)
- Pornsilapatip J, Namsiripongpun V, Wilde H, Hanvanich M, Chutivongse S. Detection of Plasmodia in acridine orange stained capillary tubes (the QBC system). (who.int)
- The sensitivity, specificity and convenience of carrying out malaria diagnosis in acridine orange stained capillary tubes using a fluorescent microscope (the QBC system) was compared to screening for Plasmodia on conventional Giemsa stained thick smears. (who.int)
- As one of the trusted manufacturer, exporter and supplier of allied domain, we have been engaged in providing our clients with excellent quality ACRIDINE ORANGE ZNCL2 . (arnishlaborates.in)
- By acridine orange staining. (cdc.gov)
- scintillation counter, doing acridine orange direct counts. (bio.net)
- Microscopically, recognition of Borrelia may be enhanced by Pappenheim-stained cytospin preparation from CSF, and, to increase the sensitivity, preparation with acridine orange may be performed. (medscape.com)
- 2022: Sorption of acridine orange on non-swelling and swelling clay minerals, Crystals (118 pp. (uwp.edu)
- TUNEL assay and acridine orange fluorescence staining were carried out to investigate the molecular mechanismsresponsible for the cell death. (ias.ac.in)
Derivatives7
- Acridine and its derivatives can be used to make dyes and also used in the pharmaceutical industry. (chemenu.com)
- Due to its DNA-intercalating properties, acridine or its suitable derivatives are expected to preferentially accumulate in tumors, which are always associated with enhanced DNA replication. (chemenu.com)
- Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity. (unich.it)
- To identify novel derivatives with higher neuroprotective activity, we evaluated the effects of a small library of acridine derivatives. (unich.it)
- The 6-chloro-2-methoxyacridine derivatives bearing on position 9 a quinolizidin-1-ylamino (Q1, Q2) or a quinolizidin-1-ylalkylamino residue (Q3, Q4, Q6, Q7), the thio-bioisoster of Q3 (Q5), the 9-(N-lupinylthiopropyl)amino derivative (Q8) and simple acridines (Q9 and Q10) were considered. (unich.it)
- All acridine derivatives analyzed showed high affinity binding for hPrP90-231, but only Q3 and Q10, caused a significant reduction of hPrP90-231 cytotoxicity, with higher efficacy than quinacrine. (unich.it)
- A series of 8 new derivatives of fendiline was prepared for evaluation as allosteric modulators of GABA_B receptors: 4 based on acridine and 4 with restricted distance between the 2 aryl moieties. (tubitak.gov.tr)
Reagents3
- Acridine chemiluminescence reagents mainly include acridine ester and acridine sulfonamide. (vacutaineradditives.com)
- In addition, the chemiluminescence reagents of acridine ester series have very good stability and convenient storage. (vacutaineradditives.com)
- For the shortcomings of this method, such as difficult reaction steps, high cost of raw materials and reagents, which is not conducive to large-scale preparation, the traditional seven step method is optimized, and a new five step chemical reaction method for the synthesis of acridine salt is developed. (vacutaineradditives.com)
Dyes1
- Circular dichroism data also quantified the α-helicity change in hemoglobin due to the binding of acridine dyes. (jascoinc.com)
Synthesis1
- At present, there are many processes for the synthesis of acridine ester dmae-nhs, which can be attributed to the seven step method. (vacutaineradditives.com)
Propyl2
Synergistic2
- In addition, acridine-9-carboraldehyde was synergistic to both rifampicin and levofloxacin with a fractional inhibitory concentration index of ≤ 0.5. (fortunejournals.com)
- Roth D, London M. Acridine probe study into synergistic DNA-denaturing action of heat and ultraviolet light in squamous cells. (medscape.com)
Concentrations3
- Resazurin reduction microplate assay (REMA) was used to determine the minimum inhibitory concentrations of acridine-9-carboral-dehyde and 9-hydroxy-4-methoxy acridine as well as their interactions with conventional anti-TB drugs ie isoniazid, rifampicin and ciprofloxacin. (fortunejournals.com)
- Acridine-9-carboraldehyde was active on both susceptible and multidrug-resistant strains of TB with minimum inhibitory concentrations of 0.238µg/mL and 0.108 µg/mL on the pan-sensitive and clinical susceptible strains and 0.157 µg/mL and 0.196 µg/mL on the rifampicin resistant and multidrug-resistant strains respectively. (fortunejournals.com)
- Concentrations of acridine from emissions in urethane molds were the highest, 25 micrograms per gram (microg/g), 13microg/g in furan molds, and 37.7microg/g in green sand. (cdc.gov)
Compounds3
- Acridines are organic compounds and nitrogen heterocycles having the formula C13H9N. (chemenu.com)
- These data represent interesting leads for further modifications of the basic side chain and the substituent pattern of the acridine nucleus to develop novel compounds with improved antiprion activity to be tested in in vivo experimental setting. (unich.it)
- Compounds that include the structure of acridine. (bvsalud.org)
Affinity2
- Neo-acridine was a potent inhibitor of HIV-1 Rev-Response Element (RRE) binding showing a two order of magnitude higher affinity for RRE than that of the parent neomycin B. It appears that neo-acridine is the strongest competitive inhibitor of Rev-RRE binding. (bioorganic-chemistry.com)
- The affinity of neo-acridine to the RRE is only 2-fold lower than that of the Rev peptide. (bioorganic-chemistry.com)
Derivative1
- Acridine is a substituted derivative of the parent ring. (chemenu.com)
Binding1
- Overall, the results revealed that a small change in the acridine chromophore leads to remarkable alteration in the structural and thermodynamic aspects of binding to HHb. (jascoinc.com)
Acid1
- Acridine ester dmae-nhs was synthesized from 3,5-dimethyl-4-hydroxybenzoic acid and acridine 9 carboxylic acid through five steps of esterification, condensation, hydrolysis, succinyl amination and methylation. (vacutaineradditives.com)
Synthetic2
- i) to determine the antimycobacterial activity of two synthetic alkaloids i.e., acridine-9-carboraldehyde and 9-hydroxy-4-methoxy acridine on both susceptible and multidrug-resistant TB clinical isolates and ii) to determine interactions between the alkaloids and anti-TB drugs iii) to determine the toxicity profile of the most active alkaloid. (fortunejournals.com)
- Based on the above understanding, the synthetic method and evolutionary history of acridine salt dmae-nhs. (vacutaineradditives.com)
Addition1
- In addition, the chemiluminescence process of acridine ester reacts rapidly and has low background. (vacutaineradditives.com)
Salt1
- Among them, acridine ester series has many models: acridine ester (dmae-nhs, nsp-dmae-nhs, me-dmae-nhs), acridine salt (nsp-sa, nsp-sa-nhs), acridine hydrazide nsp-sa-adh and other products. (vacutaineradditives.com)
Types1
- There are many types of acridine esters, such as acridine ester dmae-nhs. (vacutaineradditives.com)
Active1
- Acridine-9-carboraldehyde is active against clinical isolates of multidrug-resistant M. tuberculosis. (fortunejournals.com)
High2
- Acridine ester is a very important chemiluminescence reagent with high quantum yield. (vacutaineradditives.com)
- The chemiluminescence efficiency of acridine ester is relatively high, which is generally five times or more than five times that of luminol. (vacutaineradditives.com)
Products1
- In recent years, with the development of chemiluminescence application technology and instruments, especially the expanded application of acridine ester series products, it has a very significant effect. (vacutaineradditives.com)