A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.
Acridines which are substituted in any position by one or more amino groups or substituted amino groups.
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
Topical antiseptic used mainly in wound dressings.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
A topically applied anti-infective agent.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
Chemical substances that interrupt pregnancy after implantation.
PHENOTHIAZINES with an amino group at the 3-position that are green crystals or powder. They are used as biological stains.
Plasmids which determine the ability of a bacterium to ferment lactose.
Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. Many of them are naturally occurring alkaloids.
Products of the hydrolysis of chlorophylls in which the phytic acid side chain has been removed and the carboxylic acids saponified.
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Strong alkylating and immunosuppressive agents whose biological activity is based on the presence of bis(2-chloroethyl)- groups. Although otherwise structurally diverse, the compounds have in common the capacity to contribute alkyl groups to DNA. They are generally highly toxic but include among their number many widely used and effective antineoplastic agents.
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
An aniline dye used as a disinfectant and an antiseptic agent. It is weakly fluorescing and binds specifically to certain proteins.
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.
Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
A neoplasm containing HISTIOCYTES. Important forms include BENIGN FIBROUS HISTIOCYTOMA; and MALIGNANT FIBROUS HISTIOCYTOMA.

Characterization of nuclear structures containing superhelical DNA. (1/786)

Structures resembling nuclei but depleted of protein may be released by gently lysing cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids sediment in gradients containing intercalating agents in a manner characteristic of DNA that is intact, supercoiled and circular. The concentration of salt present during isolation of human nucleoids affects their protein content. When made in I-95 M NaCl they lack histones and most of the proteins characteristic of chromatin; in 1-0 M NaCl they contain variable amounts of histones. The effects of various treatments on nucleoid integrity were investigated.  (+info)

Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. (2/786)

Class I P-glycoproteins (Pgp) confer multidrug resistance in tumors, but the physiologic function of Pgp in normal tissues remains uncertain. In cells derived from tissues that normally express Pgp, recent data suggest a possible role for Pgp in cholesterol trafficking from the plasma membrane to the endoplasmic reticulum. We investigated the esterification of plasma membrane cholesterol under basal conditions and in response to sphingomyelinase treatment in transfected and drug-selected cell lines expressing differing amounts of functional class I Pgp. Compared with parental NIH 3T3 fibroblasts, cells transfected with human multidrug resistance (MDR1) Pgp esterified more cholesterol both without and with sphingomyelinase. Esterification also was greater in drug-selected Dox 6 myeloma cells than parental 8226 cells, which express low and non-immunodetectable amounts of Pgp, respectively. However, no differences in total plasma membrane cholesterol were detected. Transfection of fibroblasts with the multidrug resistance-associated protein (MRP) did not alter esterification, showing that cholesterol trafficking was not generally affected by ATP-binding cassette transporters. Steroidal (progesterone, dehydroepiandrosterone) and non-steroidal antagonists (verapamil, PSC 833, LY335979, and GF120918) were evaluated for effects on both cholesterol trafficking and the net content of 99mTc-Sestamibi, a reporter of drug transport activity mediated by Pgp. In Pgp-expressing cells treated with nonselective and selective inhibitors, both the kinetics and efficacy of inhibition of cholesterol esterification differed from the antagonism of drug transport mediated by Pgp. Thus, although the data show that greater expression of class I Pgp within a given cell type is associated with enhanced esterification of plasma membrane cholesterol in support of a physiologic function for Pgp in facilitating cholesterol trafficking, the molecular mechanism is dissociated from the conventional drug transport activity of Pgp.  (+info)

Serum sErbB1 and epidermal growth factor levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. (3/786)

Epithelial ovarian cancer (EOC) has a high mortality rate, which is due primarily to the fact that early clinical symptoms are vague and nonspecific; hence, this disease often goes undetected and untreated until in its advanced stages. Sensitive and reliable methods for detecting earlier stages of EOC are, therefore, urgently needed. Epidermal growth factor (EGF) is a ligand for EGF receptor (ErbB1); this receptor is the product of the c-erbB1 proto-oncogene. ErbB1 overexpression is common in human ovarian carcinoma-derived cell lines and tumors, in which overexpression is thought to play a critical role in tumor etiology and progression. Furthermore, ErbB1 overexpression is associated with disease recurrence and decreased patient survival. Recently, we have developed an acridinium-linked immunosorbent assay that detects a approximately 110-kDa soluble analogue of ErbB1, ie., sErbB1, in serum samples from healthy men and women (A. T. Baron, et al., J. Immunol. Methods, 219: 23-43, 1998). Here, we demonstrate that serum p110 sErbB1 levels are significantly lower in EOC patients with stage III or IV disease prior to (P < 0.0001) and shortly after (P < 0.0001) cytoreductive staging laparotomy than in healthy women of similar ages, whereas EGF levels are significantly higher than those of age-matched healthy women only in serum samples collected shortly after tumor debulking surgery (P < 0.0001). We observe that the preoperative serum sErbB1 concentration range of advanced stage EOC patients barely overlaps with the serum sErbB1 concentration range of healthy women. In addition, we show that serum sErbB1 and EGF levels changed temporally for some EOC patients who were surgically debulked of tumor and who provided a second serum sample during the course of combination chemotherapy. Finally, we observe a significant positive association between sErbB1 and EGF levels only in serum samples of EOC patients collected prior to cytoreductive surgery (correlation coefficient = 0.61968; P = 0.0027). These data suggest that epithelial ovarian tumors concomitantly affect serum sErbB1 and EGF levels. In conclusion, these data indicate that serum sErbB1 and EGF (postoperative only) levels are significantly different between EOC patients and healthy women and that altered and/or changing serum sErbB1 and EGF levels may provide important diagnostic and/or prognostic information useful for the management of patients with EOC.  (+info)

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918. (4/786)

The acridone carboxamide derivative GG918 (N-{4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-pheny l}-9,10dihydro-5-methoxy-9-oxo-4-acridine carboxamide) is a potent inhibitor of MDR1 P-glycoprotein-mediated multidrug resistance. Direct measurements of ATP-dependent MDR1 P-glycoprotein-mediated transport in plasma membrane vesicles from human and rat hepatocyte canalicular membranes indicated 50% inhibition at GG918 concentrations between 8 nM and 80 nM using N-pentyl-[3H]quinidinium, ['4C]doxorubicin and [3H]daunorubicin as substrates. The inhibition constant K for GG918 was 35 nM in rat hepatocyte canalicular membrane vesicles with [3H]daunorubicin as the substrate. Photoaffinity labelling of canalicular and recombinant rat Mdr1b P-glycoprotein by [3H]azidopine was suppressed by 10 muM and 40 muM GG918. The high selectivity of GG918-induced inhibition was demonstrated in canalicular membrane vesicles and by analysis of the hepatobiliary elimination in rats using [3H]daunorubicin, [3H]taurocholate and [3H]cysteinyl leukotrienes as substrates for three distinct ATP-dependent export pumps. Almost complete inhibition of [3H]daunorubicin transport was observed at GG918 concentrations that did not affect the other hepatocyte canalicular export pumps. The high potency and selectivity of GG918 for the inhibition of human MDR1 and rat Mdr1b P-glycoprotein may serve to interfere with this type of multidrug resistance and provides a tool for studies on the function of these ATP-dependent transport proteins.  (+info)

A method for the deductive and unique determination of the values of three parameters involved in fractional functions applicable to relaxation kinetics. (5/786)

A novel method is proposed to determine deductively and uniquely the values of three parameters, a, b, and c in a fractional function of the form, y=a+bx/(c+x) where x and y are experimentally obtainable variables. This type of equation is frequently encountered in chemistry and biochemistry involving relaxation kinetics. The method of least squares with the Taylor expansion is employed for direct curve fitting of observed data to the fractional function. Approximate values of the parameters, which are always necessary prior to commending the above procedure, can be obtained by the method of rearrangement after canceling the denominator of fractional functions. This procedure is very simple, but very effective for estimating provisional values of the parameters. Deductive and unique determination of the parameters involved in the fractional function shown above can be accomplished for the first time by the combination of these two procedures. This method is extended to include the analysis of relaxation kinetic data such as those of temperature-jump method where the determination of equilibrium concentrations of reactants in addition to the three parameters is also necessary.  (+info)

Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. (6/786)

BACKGROUND: Angiotensin II activates NAD(P)H-dependent oxidases via AT1-receptor stimulation, the most important vascular source of superoxide (O2*-). The AT1 receptor is upregulated in vitro by low-density lipoprotein. The present study was designed to test whether hypercholesterolemia is associated with increased NAD(P)H-dependent vascular O2*- production and whether AT1-receptor blockade may inhibit this oxidase and in parallel improve endothelial dysfunction. METHODS AND RESULTS: Vascular responses were determined by isometric tension studies, and relative rates of vascular O2*- production were determined by use of chemiluminescence with lucigenin, a cypridina luciferin analogue, and electron spin resonance studies. AT1-receptor mRNA was quantified by Northern analysis, and AT1-receptor density was measured by radioligand binding assays. Hypercholesterolemia was associated with impaired endothelium-dependent vasodilation and increased O2*- production in intact vessels. In vessel homogenates, we found a significant activation of NADH-driven O2*- production in both models of hyperlipidemia. Treatment of cholesterol-fed animals with the AT1-receptor antagonist Bay 10-6734 improved endothelial dysfunction, normalized vascular O2*- and NADH-oxidase activity, decreased macrophage infiltration, and reduced early plaque formation. In the setting of hypercholesterolemia, the aortic AT1 receptor mRNA was upregulated to 166+/-11%, accompanied by a comparable increase in AT1-receptor density. CONCLUSIONS: Hypercholesterolemia is associated with AT1-receptor upregulation, endothelial dysfunction, and increased NADH-dependent vascular O2*- production. The improvement of endothelial dysfunction, inhibition of the oxidase, and reduction of early plaque formation by an AT1-receptor antagonist suggests a crucial role of angiotensin II-mediated O2*- production in the early stage of atherosclerosis.  (+info)

Paracrine role of adventitial superoxide anion in mediating spontaneous tone of the isolated rat aorta in angiotensin II-induced hypertension. (7/786)

The relationship between vascular generation of superoxide anion and spontaneous tone observed in the isolated aorta was studied in hypertensive rats infused with angiotensin II. Aortic rings from hypertensive, but not from sham-operated rats, demonstrated oscillatory spontaneous tone that represented 52+/-5.6% of the maximal contraction to KCl. Spontaneous tone was prevented by calcium-free buffer or by blocking calcium influx through L-type calcium channels with nifedipine. The production of superoxide anion measured by lucigenin chemiluminescence was up to 15-fold higher than in sham-operated rat aorta. The adventitial site of production of superoxide anion was suggested by the fact that lucigenin chemiluminescence was 5.5-fold higher from the adventitia than from the intima. This was confirmed histochemically by demonstrating that the adventitia was the site of reduction of nitroblue tetrazolium as well as immunohistochemical staining of NAD(P)H oxidase subunit proteins. A causal link between superoxide anion production by NAD(P)H oxidase and the spontaneous tone is suggested by the fact that superoxide dismutase or the inhibitor of NAD(P)H oxidase, diphenylene iodonium, decreased both superoxide anion production and spontaneous tone. L-NAME or removal of the endothelium from the aorta had no significant effect on superoxide anion levels or spontaneous tone. However, although superoxide dismutase decreased superoxide anion levels in the presence of L-NAME or in endothelium-denuded rings, it no longer inhibited the tone. This suggests that the effect on tone of superoxide anion originating in the adventitia is mediated by inactivating endothelium-derived nitric oxide, which promotes smooth muscle calcium influx and spontaneous tone. The adventitia is not a passive bystander during the development of hypertension, but rather it may have an important role in the regulation of smooth muscle tone.  (+info)

Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation. (8/786)

Lucigenin-amplified chemiluminescence has frequently been used to assess the formation of superoxide in vascular tissues. However, the ability of lucigenin to undergo redox cycling in purified enzyme-substrate mixtures has raised questions concerning the use of lucigenin as an appropriate probe for the measurement of superoxide production. Addition of lucigenin to reaction mixtures of xanthine oxidase plus NADH resulted in increased oxygen consumption, as well as superoxide dismutase-inhibitable reduction of cytochrome c, indicative of enhanced rates of superoxide formation. Additionally, it was revealed that lucigenin stimulated oxidant formation by both cultured bovine aortic endothelial cells and isolated rings from rat aorta. Lucigenin treatment resulted in enhanced hydrogen peroxide release from endothelial cells, whereas exposure to lucigenin resulted in inhibition of endothelium-dependent relaxation in isolated aortic rings that was superoxide dismutase inhibitable. In contrast, the chemiluminescent probe coelenterazine had no significant effect on xanthine oxidase-dependent oxygen consumption, endothelial cell hydrogen peroxide release, or endothelium-dependent relaxation. Study of enzyme and vascular systems indicated that coelenterazine chemiluminescence is a sensitive marker for detecting both superoxide and peroxynitrite.  (+info)

Synonyms for acridine dye in Free Thesaurus. Antonyms for acridine dye. 30 synonyms for dye: colour, stain, tint, shade, tinge, pigment, tincture, colour-wash, colouring, colour, pigment, wash, stain, tint, tinge, colorant, color. What are synonyms for acridine dye?
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The objective of this study was to characterize the influence of P-gp and Bcrp at the mouse BBB on the nonlinear CNS distribution of elacridar. This compound has been widely used as a P-gp and Bcrp inhibitor, both in vitro and in vivo. However, the brain distribution of elacridar has not been fully characterized. Earlier studies using radiolabeled elacridar and positron emission tomography qualitatively examined the CNS distribution of elacridar-associated radioactivity in wild-type, P-gp knockout, Bcrp knockout, and triple knockout mice (Dorner et al., 2009; Kawamura et al., 2011a,b). The results from those studies indicated that P-gp and Bcrp could play a role in limiting the brain distribution of elacridar. Our previous study (Sane et al., 2012) was the first to quantitatively examine the brain distribution of elacridar in wild-type mice using a specific stability-indicating assay (LC-MS/MS). The current study examined various factors that could influence elacridar brain distribution, ...
Since the properties of small molecules can change upon conjugation to proteins, we investigated the binding of CB[8] to TMV-6 following the confirmation of the TMV-6 conjugate. Since the solutions of TMV-6 at concentrations required for ITC characterization were subject to viscosity and adhesion issues, a fluorescence titration was used instead to determine a dissociation constant. In this case, neither TMV-6 nor CB[8] contain fluorophores, so a competitive binding strategy incorporating a fluorophore was implemented. Acridine-3,6-diamine, or proflavin (PF), is an acridine derivative that is fluorescent as a free molecule in aqueous solutions, but its fluorescence becomes quenched68,69 upon binding inside the cavity of CB[8]. A fluorescence titration of increasing concentrations of TMV-6 (0-20 μM relative to TEMPO) titrated into solutions with a constant concentration of the CB[8]⊃PF (0.2 μM) complex was performed. Upon the addition of increasing concentrations of TMV-6, the observed ...
Lookchem Provide Cas No.118474-59-2 Basic information: Properties,Safety Data,Sds and Other Datebase. We also Provide Trading Suppliers & Manufacture for 118474-59-2 10-{3-[(2-aminoethyl)amino]propyl}-3,6-bis(dimethylamino)acridinium platinum(2+) chloride (1:1:3).
Structure, properties, spectra, suppliers and links for: 4-[(5-{[5-(2,4-Dichlorophenyl)-3,4-dihydro-2(1H)-isoquinolinyl]methyl}-1H-imidazol-1-yl)methyl]b.
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(E)-6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phenyl}-6-pyridin-3-yl-hex-5-enoic acid amide | C25H26ClN3O3S | CID 10254733 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Fluorescent staining of chromosomes and nuclear structures (nucleolus associated chromatin) in living HeLa- and LM-cells (mouse fibroblasts) with new acridine dyes is reported. The dyes have...
This Ambrosial Oranges recipe is so delicious and full of flavor. Its one of the many great recipes shared by home cooks on BakeSpace.com, the worlds sweetest recipe swap community.
Nearly 50,000 DACA applicants are waiting for their applications to be approved. Theyll have to keep waiting after a judge ruled the program unconstitutional.
Nearly 50,000 DACA applicants are waiting for their applications to be approved. Theyll have to keep waiting after a judge ruled the program unconstitutional.
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This is now a public advertisement for the role of illustrator for my cartoons. I cant keep copy-pasting from Cyanide and Happiness and I cant keep calling my strip such an obviously ripped-off name. So, if you like to (and can, thats important) draw; if you have high hopes and low expectations; and if your…
TY - JOUR. T1 - Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition. AU - Ponder, Jessica. AU - Yoo, Byong Hoon. AU - Abraham, Adedoyin D.. AU - Li, Qun. AU - Ashley, Amanda K.. AU - Amerin, Courtney L.. AU - Zhou, Qiong. AU - Reid, Brian G.. AU - Reigan, Philip. AU - Hromas, Robert. AU - Nickoloff, Jac A.. AU - LaBarbera, Daniel V.. PY - 2011/11. Y1 - 2011/11. N2 - Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphimedine potently inhibits TopoIIá-dependent DNA decatenation in the presence of Metnase. Cell proliferation assays demonstrate that neoamphimedine can inhibit Metnase-enhanced cell growth with an IC 50 of 0.5 μM. Additionally, we find that the apparent K m of TopoIIα for ATP ...
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CAS NO:62147-65-3; Chemical name:Acetamide,N-[3,4-dihydro-3-(4-methoxyphenyl)-1-oxo-2(1H)-isoquinolinyl]- ; physical and chemical property of 62147-65-3, Acetamide,N-[3,4-dihydro-3-(4-methoxyphenyl)-1-oxo-2(1H)-isoquinolinyl]- is provided by ChemNet.com
acridine 260-94-6 MSDS report, acridine MSDS safety technical specifications search, acridine safety information specifications ect.
DISEASE CHARACTERISTICS: Histologically confirmed metastatic breast cancer Bidimensionally measurable disease of any of the following types required: Bidimensionally measurable lung lesions on chest X-ray, CT scan, or MRI Palpable and quantifiable lymph nodes at least 2 x 2 cm Abdominal mass at least 2 x 2 cm quantifiable by CT scan Bidimensionally measurable liver metastases at least 2 x 2 cm Palpable hepatomegaly if liver edge is clearly defined and extends at least 5 cm below the costal margin of the xiphoid process Unacceptable as measurable disease: Diffuse lung infiltration or unidimensionally measurable hilar lesions Pelvic mass of indefinite dimension Bone metastases Pleural effusion or ascites No brain metastases Must have failed or progressed on prior therapy or relapsed less than 12 months after therapy discontinuation Hormone receptor status: Not specified. PATIENT CHARACTERISTICS: Age: 16 and over Sex: Female Menopausal status: Not specified Performance status: SWOG 0-2 Life ...
Ø Jagannath has improved resistance to lodging, high yield, more responsive to fertilizers than its parent. Furthermore it was possible to move useful genes by specialbreeding strategies. Plant breeders must be equipped with the tools to respond quickly to new demands by developing accelerated breeding techniques and the ability to screen for traits of interest rapidly among progeny. Ø Mutation breeding can improve the disease resistance of crop plants. Meaning of Hybridization: Individual produced as a result of […] Ø In sexually reproducing plants dominant and recessive mutations are useful. Acridine dyes: Example: Proflavine, Acridine orange, Acridine yellow, Ethydium bromide, (3). Ø The mutation also increases frequency of chromosomal changes, mitotic and meiotic irregularities in the organism. Plant breeders must have access to genetic variation in crop species. The strategies used to meet these demands are increasingly based on our knowledge of relevant science, particularly genetics ...
methyl 4-(acridin-9-ylamino)benzoate | C21H16N2O2 | CID 39930 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Components: s2146 Acridine Orange Stock Solution s1656 Sorensens Phosphate Buffer pH 6.0 s2147 Calcium Chloride 0.1M Solution s100 Acetic Acid 1% Aqueous
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.
DNA intercalating dye. A grade of acridine orange of exceptionally high purity, suitable for quantitative work. Free of inorganic salts.
17784-47-3 - XUESTGHCVFYOLL-UHFFFAOYSA-N - Acridine, hydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Name:C.I.Basic Orange 14,C.I.46005 Molecular Structure: Acridines class C.I.Basic Orange 14,C.I.46005,CAS 65-61-2,301.81,C17H20ClN3,Acridine Orange C.I.Basic Orange 14,C.I.46005,CAS 65-61-2,301.81,C17H20ClN3,Acridine Orange Molecular Formula:C17H20ClN3 Molecular Weight: 301.81 CAS Registry Number:65-61-2
Herein, six ruthenium(ii) terpyridine complexes, i.e. [RuCl2(4-EtN-Phtpy)(DMSO)] (Ru1), [RuCl2(4-MeO-Phtpy)(DMSO)] (Ru2), [RuCl2(2-MeO-Phtpy)(DMSO)] (Ru3), [RuCl2(3-MeO-Phtpy)(DMSO)] (Ru4), [RuCl2(1-Bip-Phtpy)(DMSO)] (Ru5), and [RuCl2(1-Pyr-Phtpy)(DMSO)] (Ru6) with 4′-(4-diethylaminophenyl)-2,2′:6′,2′′-terpyridine
10-Bromonaphth[2,3-c]acridine-5,8,14(13H)-trione/ACM52636596 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
The conductance and switching behaviour of acene series derivative `Acridinium based organic molecular single electron transistor have been assessed in the vic
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
These orange jelly-like apothecia grow at the apex of the moss Ulota crispa. Spores measure 60-70 x 11 microns. Multiseptate. Multiguttulate. Any suggestion?
Acridine orange is a nucleic acid staining dye that is used to identify dead cells. It intercalates with the double-stranded DNA base pairs at a ratio of 1:3 and is capable of emitting green fluorescence (Ex: 500 nm, Em: 520 nm). It also emits red fluorescence (Ex: 460 nm, Em: 650 nm) when bound to RNA or single-stranded DNA. Since acridine orange is mutagenic, this product is supplied as a solution that prevents it from splashing during weighing.. ...
Short Duration Bath (2 hours) - Using an independent, separate treatment container with appropriate aeration, prepare as 10 part per million (ppm) treatment bath. Note: 10 ppm is equivalent to 10 milligrams of acriflavine per liter of treatment water or 37.8 mg per gallon of treatmet water. After 2 hours of treatment, return fish to habitat water ...
SHREEJI PHARMA International based in Gujarat, India is a manufacturer, exporter & trader of Acriflavine Neutral BPC-49 (Euflavine) at the best price.
The suggestions in this document are based on feedback we have received primarily from DACA renewal applicants. If you have any additional suggestions or feedback, please email the National Immigration Law Center (NILC) at [email protected].. Have your Deferred Action for Childhood Arrivals (DACA) and employ-ment authorization document (EAD) expired, or will they expire soon? If you have submitted your renewal application but are concerned because your DACA and work authorization have expired or will expire before your DACA is renewed, consider following the steps described below to get information about the status of your renewal application and, if appropriate, to ask U.S. Citizenship and Immigration Services (USCIS) to process your renewal more quickly.. USCIS suggests that you submit your completed renewal application at least 150 days (5 months), but no later than 120 days (4 months), before your current DACA and employment authorization document (EAD) expire. USCIS will accept your renewal ...
We have a goldfish that is white with a couple of splashes of orange on him...Over the last week we have noticed that his face and the beginning of his tail is turning yellow?
Navberedemax di navbera mejî û beşên din ên koendama demarê de girêdanan ava dike, belavkirina agahiyên ji mejî an jî ber bi mejî li vir rû dide[5]. Ango ji bilî hestê bêhngirtinê, agahiyên ji dirkepetik û demarekoendama çêwe, pêşî li vir tên tekûzkirin û yekkirin paşê tên şandin ji boy mejî[5]. Talamus û hîpotalamus beşên demaxê navberê ne û pêwendiya wan raste rast bi koendama demarê heye. Hestewergir ji her aliyê laş de demareragihandin werdigirin, bi navbeynkariya demarexaneyên hestê, demareragihandin tên şandin boy talamusê. Talamus ragihandinan ji hestedemarexane yên hatî digire, ragihandinan tekûz dike. Li talamusê ragihandinên(kartêkir) girîng ji yê ne girîng tên cihê kirin. Hêza (bandora) ragihandinan tên kêmkirn an jî zêdekirin. Piştî polenkirinê, talamus ragihandinan dişîne boy beşa guncav a tûkila mejîyê[9]. Wekî mînak gava mirov li cihekî qerebalix de hewla xwendina pirtûkek bike, talamus dengên derdorê ...
Invaziv - Dictionar termeni medicali - Cu caracter de invazie, agresivitate. O procedura medicala este invaziva, daca realizarea ei presupune lezare tisulara sau un disconfort fizic semnificativ
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Looking for online definition of acridine in the Medical Dictionary? acridine explanation free. What is acridine? Meaning of acridine medical term. What does acridine mean?
Acridine Orange hemi(zinc chloride) salt from Sigma-Aldrich,Application: Acridine orange has been used as a fluorescent stain for nucleic acids in agarose and polyacrylamide gels. Acridine orange at a concentration of 120 μM will detect purified DNA in gels with a sensitivity of 25-50 ng per band. It has also been used extensively for cell staining of,biological,biology supply,biology supplies,biology product
We do routinely use acridine orange using FACScan. A 20 min rinse with 10 times water-diluted Chlorox bleach is adequate to clean the instrument. Zbigniew Darzynkiewicz -----Original Message----- From: Karen Creswell [mailto:creswelk at georgetown.edu] Sent: Friday, June 04, 2004 1:17 PM To: cyto-inbox Subject: Acridine Orange Does anyone routinely run acridine orange through their FACScan/FACSort? I would like suggestions for cleaning the instrument afterwards. Thanks for your help, Karen -- Karen Creswell, Ph.D. Director, Flow Cytometry/Cell Sorting Shared Resource Lombardi Cancer Center Georgetown University Medical Center Research Bldg W304 Box 571469 Washington, DC 20057-1469 202-687-2233 creswelk at georgetown.edu ...
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Synthesis of carbon-11-labeled tariquidar derivatives as new PET agents for imaging of breast cancer resistance protein (ABCG2). Appl Radiat Isot. 2010 Jun; 68(6):1098-103 ...
GF120918 has a high inhibitory effect on P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). We developed [11C]GF120918 as a positron emissi
63019-59-0 - RGDUWGJRJSZSLI-LGMDPLHJSA-N - Benz(a)acridine, 12-(p-(dimethylamino)styryl)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Antitumor properties of the potent G‐quadruplex ligand 3,11‐difluoro‐6,8, 13‐trimethyl‐8H‐quino[4,3,2‐kl]acridinium methosulfate (RHPS4) are driven by telomere uncapping events. RHPS4 has good selectivity for quadruplex DNA over duplex DNA as measured by surface plasmon resonance (Kquad 1.1 × 107 M−1); Kdup 3.4 × 105 M−1). In preclinical models of solid tumor xenografts RHPS4 potentiates the activity of camptothecins but good response is dependent on the timing of the drug sequence employed. These experiments teach how an agent of this novel class might be used clinically in combination with chemotherapeutic agents. Although RHPS4 has several drug‐like qualities (synthetic accessibility, water solubility, cellular uptake), a preliminary toxicological study revealed that the compound is a potent hERG inhibitor (IC50 0.2 M) and has additional receptor interactions, notably with muscarinic M1, M2 and M3 receptors. In an anaesthetized guinea pig cardiac model RHPS4 increased ...
Some clones, Hfr, were selected, either at high temperature or at low temperature in the presence of acridine on the basis of mutated bacteria whose F episome does not multiply at high temperature in the autonomous state. The integration mechanisms of the episome and of the chromosomal transfer by I strains may be deduced from the properties of these strains. The sex episome of Escherichia coli K 12, in the autonomous state, confers on the bacterium that carries it F the capability of being paired with a bacterium F- and of transferring episome F to it at high frequency. The integration of the episome and of the chromosome creates a new type of male bacterium Hfr, which transfers an oriented group of chromosomal genes at high frequency, but does not transfer the autonomous episome F. A third sexual type, intermediary type I, has also been observed recently. The I bacteria transfer the episome by crossing the autonomous state with the same efficacy as the F bacteria. Like the Hfr bacteria, on the other
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Copyright The Student Room 2017 all rights reserved. The Student Room, Get Revising and Marked by Teachers are trading names of The Student Room Group Ltd.. Register Number: 04666380 (England and Wales), VAT No. 806 8067 22 Registered Office: International House, Queens Road, Brighton, BN1 3XE. ...
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Sigma-Aldrich offers Aldrich-A38401, 9-Aminoacridine hydrochloride monohydrate for your research needs. Find product specific information including CAS, MSDS, protocols and references.
Mindat ah rallokap hna nih facang phorh lo ding in ri an khiah piak hna caah facang a dih. Chin ramkulh Mindat peng ah facang phorhnak nawl cu rallokap hna nih ri an khiah caah a dang khua in facang nan rak phorh a si ahcun minung pakhat caah facang pyi 10 cio lawng nan phorh lai tiah ri an khiah piak hna.. Chuahluhnak gate ah an checktuk caah phone hna an check i an tlaih mi hna hi nifatin pehzulh in an um.Tu lio Mindat khua chung ah facang le Datsi, Diesel hna a dih.. A hlan ahcun khua chungah facang zuarnak nawl minthut he facang tun 10 tiang luhpi a ngah than.Atu cu khuachung ah facang zuar a ngah ti lo. Kyout Htu in facang va cawk ah minung pakhat ah pyi 10 lawng phorh nak nawl a um tiah Mindat khua mi pakhat nih a chim.. Tu lio cu rallokap hna nih khuami hna cu an tlaoh hna i an thil /pawta an phorh ter hna i chungkhar cazin an check tiah theih a si.#Mizzima. ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
To peel the oranges cut both ends and place the orange on one end on a cutting board. Using a sharp knife shave the peel off downwards all the way around, making sure to also remove the thin white skin around the orange. Chop the orange into small pieces. Weigh the chopped orange. ...
my Medium Plus is looking a bit too light or my skin right now. It looks fine when I first apply it, but out in daylight the color is a bit off. My skin now is about NC35... anyone in that range wear Medium Dark in MSFN? some users on MUA have said this turns orange on them.. anyone here have ...
My g/fs step dad has a 30-35g tank with 3 or 4 goldfish and 2 others of a different kind. I notced his goldfish arent lookin really gold. They look awful, more like silver fish with spots of orange on em. One goldfish has a black patch covering most of the top of him and his head. His tank looks awful. The walls look like they never been scrubbed. Ibelieve hes running a aquaclear 200 if I remmebr correctly. But the media looks disgusting. I remmebr he had a Betta in their awhile back and it
If we want potatoes and oranges on grocery shelves 10 years from now, were going to have to dig in to some inconvenient science.
Fluorescent micrographs and quantitative analysis of CAOV-3 cells double-stained with acridine orange and propidium iodide. Cells were treated with liriodenine
Acriflavine related products. MedChemExpress provides thousands of inhibitors, modulators and agonists with high purity and quality, excellent customer reviews, precise and professional product citations, tech support and prompt delivery.
It is designed to maintain a strong seal in cold climates and applications where significant cooling occurs due to high pressure drop.
Cookie-uri pentru analiza vizitatorilor. De fiecare data cand un utilizator viziteaza acest site softul de analytics furnizat de o terta parte genereaza un cookie de analiza a utilizatorului. Acest cookie ne spune daca ati mai vizitat acest site pana acum. Browserul ne va spune daca aveti acest cookie, iar daca nu, vom genera unul. Acesta permite monitorizarea utilizatorilor unici care ne viziteaza si cat de des o fac. Atat timp cat nu sunteti inregistrat pe acest site, acest cookie nu poate fi folosit pentru a identifica persoanele fizice, ele sunt folosite doar in scop statistic. Daca sunteti inregistrat putem sti, de asemenea, detaliile pe care ni le-ati furnizat, cum ar fi adresa de e-mail si username-ul - acestea fiind supuse confidentialitatii si prevederilor din Termeni si Conditii, Politica de confidentialitate precum si prevederilor legislatiei in vigoare cu privire la protejarea datelor cu caracter personal.. Cookie-uri pentru geotargetting. Aceste cookie-uri sunt utilizate de catre un ...
Trumps cruel decision to phase out DACA by March is causing chaos for undocumented youth--and bringing important movement debates to a head.
daca/dapa The enforcement of immigration laws is a complex and hotly-debated topic. Learn more about the costs of immigration enforcement and the ways in which the U.S. can enforce our immigration laws humanely and in a manner that ensures due process.
As the last renewal for DACA sets in, teachers in the program worry about their futures and the possibility of having to leave their students.
Cum returnezi. Ne dorim ca produsele noastre sa ajunga la tine in cele mai bune conditii. Daca esti dezamagit in orice fel am vrea sa stim, de aceea contacteaza-ne daca este cazul.. Ai la dispozitie un termen de 14 (paisprezece) zile calendaristice de la data la care ai intrat in posesia fizica a produselor pentru a-ti exercita dreptul legal de retragere, fara a fi obligat sa-ti motivezi decizia.. Produsul poate fi returnat numai daca este in conditii perfecte, inclusiv ambalajul, adica sa nu prezinte sub nici o forma semne de uzura sau consum, sa fie nedesfacut, respectiv sigilat.. Detalii despre retur ...
The Trump administration said Thursday night it would not immediately remove protections from so-called Dreamers who were brought to the country illegally as children.
Slim Fit: slabire sigura cu cetona de zmeura, Supliment alimentar, foarte eficient, creat special pentru a induce pierderea in greutate. Slim Fit actioneaza si mai rapid daca este asociat cu un regim minim de exercitiu fizic, chiar si daca acesta este de doar la 10-15 minute de mers pe jos., Cura de slabire
Datorita folosirii EAP (Extensible Authentication Protocol), in 802.1x se pot utiliza diverse mecanisme de autentificare: EAP-MD5, LEAP, EAP-TLS, EAP-TTLS, EAP-MSCHAPv2. Primele doua mecanisme de autentificare folosesc combinatia nume/parola, iar celelalte necesita existenta certificatelor. Autentificarea 8021x se mai numeste si port-based. Un port al autentificatorului se poate afla in doua stari logice: controlled port si uncontrolled port. In starea contolled port se permite (daca accesul a fost autorizat) sau interzice traficul (daca accesul nu a fost autorizat) care trece prin acel port. In uncontrolled port se permite doar traficul cadrelor EAPOL.. In continuare, se realizeaza o retea 802.1x cu autentificare EAP-MD5. Ca server de autentificare se foloseste freeradius instalat pe Ubuntu Lucid, iar ca autentificator un switch Cisco.. ...
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am descoperit blogul tau rasfoind alte bloguri si nu stiu daca Phoenix din fundalul citirii blogului tau m-a facut sa fiu tare placut surprins de acesta....o sa fac o mica parte de publicitate (daca te superi imi spui) si pe blogul meu....foarte interesant si visator blogul tau....felicitari ...
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... is easily oxidized by peroxymonosulfuric acid to the acridine amine oxide. The carbon 9-position of acridine is ... biologically active acridines, applications of acridines, new syntheses and reactions of acridines] Wikisource has original ... Acridine and its homologues are weakly basic. Acridine is a photobase which has a ground state pKa of 5.1, similar to that of ... Acridine and related derivatives (such as amsacrine) bind to DNA and RNA due to their abilities to intercalate. Acridine orange ...
... damages DNA and is used as a mutagen in microbiology. Acridine yellow is similar to acridine orange. According ... Acridine yellow, also known as acridine yellow G, acridine yellow H107, basic yellow K, and 3,6-diamino-2,7-dimethylacridine, ... It is a derivate of acridine. In histology, it is used as a fluorescent stain, and as a fluorescent probe for non-invasive ... Acridine yellow absorption and emission spectra v t e (Articles needing additional references from July 2021, All articles ...
... is derived from the organic molecule acridine, which was first discovered by Carl Grabe and Heinrich Caro, who ... Acridine orange and fluorescein have a maximum excitation at 502nm and 525 nm (green). When acridine orange associates with RNA ... Acridine orange is useful in the rapid screening of ordinarily sterile specimens. When acridine orange is used with flow ... Acridine dyes are prepared via the condensation of 1,3-diaminobenzene with suitable benzaldehydes. Acridine orange is derived ...
... is a chemotherapy agent that is being studied in the treatment of cancer. It belongs to the family of ... Ondansetron, an isomer of Acridine carboxamide Dittrich C, Dieras V, Kerbrat P, Punt C, Sorio R, Caponigro F, et al. (August ... Acridines, All stub articles, Antineoplastic and immunomodulating drug stubs). ...
The Bernthsen acridine synthesis is the chemical reaction of a diarylamine heated with a carboxylic acid (or acid anhydride) ... The use of polyphosphoric acid will give acridine products at a lower temperature, but also with decreased yields. Bernthsen, A ... and zinc chloride to form a 9-substituted acridine. Using zinc chloride, one must heat the reaction to 200-270 °C for 24hrs. ...
Ferguson LR, Denny WA (September 1991). "The genetic toxicology of acridines". Mutation Research. 258 (2): 123-60. doi:10.1016/ ... Most intercalators are aromatic and planar molecules; examples include ethidium bromide, acridines, daunomycin, and doxorubicin ...
Bernthsen, August (1884). "Die Acridine". Justus Liebig's Annalen der Chemie (in German). 224 (1-2): 1-56. doi:10.1002/jlac. ... Synthese der Acridine". Berichte der Deutschen Chemischen Gesellschaft (in German). 16 (2): 1802-1819. doi:10.1002/cber. ...
Cairns Smith, A. G. (1957). "Studies in the acridine series". {{cite journal}}: Cite journal requires ,journal= (help) Dennett ...
It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial ...
Denny (2002). "Acridine Derivatives as Chemotherapeutic Agents". Current Medicinal Chemistry. 9 (18): 1655-65. doi:10.2174/ ... Gatasheh, Mansour K; Kannan, S; Hemalatha, K; Imrana, N (2017). "Proflavine an acridine DNA intercalating agent and strong ... Acridines, DNA intercalaters, All stub articles, Molecular and cellular biology stubs). ...
... also binds to acridine orange. Chlorophyllin has been validated to exhibit ameliorative effects against food ...
Acridine is an isomer of phenanthridine. Phenanthridine was discovered by Amé Pictet and H. J. Ankersmit in 1891 by pyrolysis ...
Examples include ethidium bromide and acridine.[citation needed] Mismatched base pairs can be generated by errors of DNA ...
Lerman, L. S. (1963). "The structure of the DNA-acridine complex". Proc. Natl. Acad. Sci. USA. 49 (1): 94-102. Bibcode:1963PNAS ... Lerman, L. S. (1961). "Structural considerations in the interactions of deoxyribonucleic acid and acridines". Journal of ...
Lerman, L. S. (1963). "The structure of the DNA-acridine complex". Proceedings of the National Academy of Sciences of the ... Lerman, L. S. (1961). "Structural considerations in the interaction of DNA and acridines" (PDF). Journal of Molecular Biology. ... 9 epoxide of aflatoxin B1 and acridines such as proflavine or quinacrine. Intercalation as a mechanism of interaction between ...
It is observed in compounds such as calixarenes and acridines. Peri-substitution occurs in naphthalenes for substituents at the ...
Derivatives are formed in moderate to good yield; acridine is essential for high reaction efficiency. Jiao et al. enabled the ...
He discovered the therapeutic qualities of acridine dyes. He was born on 21 May 1881 the son of Friederike Sophia Pauline (née ...
Acridine derivatives: proflavin, acridine orange, acridine yellow, etc. Arylmethine derivatives: auramine, crystal violet, ...
"Synthesis of Twisted Intercalating Nucleic Acids Possessing Acridine Derivatives. Thermal Stability Studies". Bioconjugate ...
Darzynkiewicz Z, Kapuscinski J. (1990)"Acridine Orange, a Versatile Probe of Nucleic Acids and Other Cell Constituents." ... Another example of metachromatic dye (fluorochrome) is acridine orange. Under certain conditions it stains single-stranded ...
... is also a precursor to certain acridine dyes. Via aldol condensations, benzaldehyde is converted into derivatives ...
Hathaway WE, Newby LA, Githens JH (1964). "The Acridine Orange Viability Test Applied to Bone Marrow Cells. I. Correlation with ...
Polymorphism of organic substances: acridine, catechol, diphenylamine and suberic acid) -- (1943). "Mikro-Thermoanalyse ...
Acridine has been obtained as eight polymorphs and aripiprazole has nine. The record for the largest number of well- ... Acridine Solid Form Landscape: Eight Polymorphs and a Hydrate" (PDF). Crystal Growth & Design. 19 (8): 4884-4893. doi:10.1021/ ...
"Zincate-Mediated Arylation Reactions of Acridine: Pre- and Postarylation Structural Insights" (PDF). Organometallics. 34 (11): ...
Cell apoptosis is tested by treating the lysosomal membrane with acridine orange. Acridine orange radiates a red fluorescent ...
Traganos F, Darzynkiewicz Z (1994). "Lysosomal proton pump activity: supravital cell staining with acridine orange ...
His project was a study of the effects of acridines on the replication of bacteriophage T4 DNA. He received his Ph.D. in ...
Clark, Ewan R.; Ingleson, Michael J. (2013-11-25). "[(acridine)BCl2]+: A Borenium Cation That Is a Strong Boron- and Carbon- ...
Fluorescent microscopy and the identification of malaria parasites using an acridine-orange staining technique / by G. T. Shute ...
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Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: Elucidation of their molecular ... Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: Elucidation of their molecular ... Home / KnowledgeBase Articles / Binding of fluorescent acridine dyes acridine orange and 9-aminoacridine to hemoglobin: ... The molecular interaction between hemoglobin (HHb), the major human heme protein, and the acridine dyes acridine orange (AO) ...
... Molecular ... 2-ethyl-6-methyl-phenyl)carbamoylmethyl (4E)-4-[(4-methoxyphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylate ...
In the nanosol substrate, the molecular probe of acridine red (AR) exhibited a weak surface-enhanced Raman scattering (SERS) ... From: SERS Detection of Dopamine Using Label-Free Acridine Red as Molecular Probe in Reduced Graphene Oxide/Silver Nanotriangle ...
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We also provide custom synthesis and GMP manufacturing services.where to buy Acridines ... where to buy Acridines, Chemenu is research-based manufacturer of pharmaceutical intermediates and fine chemicals offering ... Acridines. Acridines are organic compounds and nitrogen heterocycles having the formula C13H9N. Acridine is a substituted ... Acridine and its derivatives can be used to make dyes and also used in the pharmaceutical industry. Acridine is a DNA ...
Scrabble Solver word definintion for ACRIDINES - ACRIDINE, a chemical compound [n] ... ACRE ACREAGE ACREAGES ACRED ACRES ACRID ACRIDER ACRIDEST ACRIDIN ACRIDINE Next Words. ACRIDINS ACRIDITIES ACRIDITY ACRIDLY ...
Pornsilapatip J, Namsiripongpun V, Wilde H, Hanvanich M, Chutivongse S. Detection of Plasmodia in acridine orange stained ... The sensitivity, specificity and convenience of carrying out malaria diagnosis in acridine orange stained capillary tubes using ... Detection of Plasmodia in acridine orange stained capillary tubes (the QBC system).. ...
Acridine. 65996-93-2. GF8655000. Acroleic acid. 79-10-7. AS4375000. Acrolein *. 107-02-8. AS1050000. ...
Acridine testing. Laboratory testing for Dibenzo(b,e)pyridine 260-94-6. is colourless to light yellow crystals ...
Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different ... Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different ... Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different ... The fluorescent dye 10-N-nonyl acridine orange (NAO) is extensively used for location and quantitative assays of cardiolipin in ...
... neo-acridine) was synthesized by covalently linking neomycin B to 9-aminoacridine via a short spacer. ... Neomycin-acridine conjugate (neo-acridine) was synthesized by covalently linking neomycin B to 9-aminoacridine via a short ... of 1.5 nM and effectively disrupts the Rev-RRE complex. The affinity of neo-acridine to the RRE is only 2-fold lower than that ... It appears that neo-acridine is the strongest competitive inhibitor of Rev-RRE binding. It binds the RRE with an inhibition ...
Polycyclic Aromatic Hydrocarbons (PAHs): What Are Polycyclic Aromatic Hydrocarbons (PAHs)?
By acridine orange staining. ,,,Click on the PDF icon to the left to view a copy of this virus entry in PDF format. You can get ...
The results show that pyrazolo[4,3-a]acridines with R=propyl, butyl, isobutyl and R=chlorine substituents have suitable ... 11] Marjani A.P., Khalafy J., Chitan M., Mahmoodi S., Microwave-Assisted Synthesis of Acridine-1,8(2h,5h)-diones via a One-Pot ... 16] Goodell J.R., Madhok A.A., Hiasa H., Ferguson D.M., Synthesis and Evaluation of Acridine-and Acridone-Based Anti-Herpes ... The results show that pyrazolo[4,3-a]acridines with R=propyl, butyl, isobutyl and R=chlorine substituents have suitable ...
Manufacturer, supplier, Trader and wholesaler of Acridine Orange Zncl2 offered by ARNISH LABORATES PRIVATE LIMITED. at latest ... ACRIDINE ORANGE ZNCL2. As one of the trusted manufacturer, exporter and supplier of allied domain, we have been engaged in ... Moreover, our clients can purchase this ACRIDINE ORANGE ZNCL2 negotiable prices from us. ... providing our clients with excellent quality ACRIDINE ORANGE ZNCL2. This chemical is widely used in processing of xylenlol ...
Anti-Mycobacterial and Synergistic Activity of Synthetic Acridine-9-Carboraldehyde and 9-Hydroxy-4-Methoxy Acridine Alkaloids ... Two synthetic acridine alkaloids ie 9-hydroxy-4-methoxy acridine (fig 1) (101760-sv) and acridine-9-carboraldehyde (Fig 2) (# ... acridine 9 carboradehyde and (iv) levofloxacin/ acridine 9 carboradehyde on the rifampicin resistant isolate; (v) acridine 9 ... In this study, acridine-9-carboraldehyde, a synthetic acridine alkaloid was active against the clinical susceptible TB isolates ...
Seedlings From -S Have More Acridine Orange-Stained Red Spots. Acridine Orange (AO) is a membrane-penetrable fluorescent dye ... Acridine orange (AO) staining of the roots of plants grown in -S in the presence and absence of Torin1. ... Figure 2. Comparison of the roots stained with acridine orange (AO). (A) Sulfur starvation increases the number of acidic ... Figure 2. Comparison of the roots stained with acridine orange (AO). (A) Sulfur starvation increases the number of acidic ...
Acridine 46000-46999 Category:Acridine dyes Quinoline 47000-47999 Category:Quinoline dyes ...
So, While Im playing the game the game with crash to desktop, no warning or notification of the crash the game will just close and I have to relaunch the game. I am running the game through the Epic Games Store. My specs are: CPU: Ryzen 7 1700X OCed to 3.8Ghz GPU: 2x RX 580 8Gbs OS: Windows 10 P...
Auramine O and acridine orange staining procedure. In: Standard operating procedure. Ames (IA): Center for Veterinary Biologics ... Any granulomatous lesions were then stained with a modified Ziehl-Neelson procedure and an auramine orange and acridine orange ...
Acridine orange staining Acridine Orange (AO) and Evans Blue (EB) at 1 mg each were dissolved in 10 mL of pH 7.2 PBS to prepare ...
Acridine Orange staining. Acridine Orange staining was performed as described(Perkins et al., 2005). ... or in the vital incorporation of Acridine Orange (not shown). ...
Categories: Acridines Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 1 images ...
1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-endo-1,4-exo-5,8-dimethanonaphthalene; HHDN; octalene; Seedrin; Aldrite; Aldrosol. ...
... Villa V;Tonelli M; ... All acridine derivatives analyzed showed high affinity binding for hPrP90-231, but only Q3 and Q10, caused a significant ... All acridine derivatives analyzed showed high affinity binding for hPrP90-231, but only Q3 and Q10, caused a significant ... To identify novel derivatives with higher neuroprotective activity, we evaluated the effects of a small library of acridine ...
... acridine-9,9-fluorene], CAS No.: 1241891-64-4, MF: C31H2BrN, MW: 486.4, Purity: 99%+ ...
  • The molecular interaction between hemoglobin (HHb), the major human heme protein, and the acridine dyes acridine orange (AO) and 9-aminoacridine (9AA) was studied by various spectroscopic, calorimetric and molecular modeling techniques. (jascoinc.com)
  • IMSEAR at SEARO: Detection of Plasmodia in acridine orange stained capillary tubes (the QBC system). (who.int)
  • Pornsilapatip J, Namsiripongpun V, Wilde H, Hanvanich M, Chutivongse S. Detection of Plasmodia in acridine orange stained capillary tubes (the QBC system). (who.int)
  • The sensitivity, specificity and convenience of carrying out malaria diagnosis in acridine orange stained capillary tubes using a fluorescent microscope (the QBC system) was compared to screening for Plasmodia on conventional Giemsa stained thick smears. (who.int)
  • As one of the trusted manufacturer, exporter and supplier of allied domain, we have been engaged in providing our clients with excellent quality ACRIDINE ORANGE ZNCL2 . (arnishlaborates.in)
  • By acridine orange staining. (cdc.gov)
  • scintillation counter, doing acridine orange direct counts. (bio.net)
  • Microscopically, recognition of Borrelia may be enhanced by Pappenheim-stained cytospin preparation from CSF, and, to increase the sensitivity, preparation with acridine orange may be performed. (medscape.com)
  • 2022: Sorption of acridine orange on non-swelling and swelling clay minerals, Crystals (118 pp. (uwp.edu)
  • TUNEL assay and acridine orange fluorescence staining were carried out to investigate the molecular mechanismsresponsible for the cell death. (ias.ac.in)
  • Acridine and its derivatives can be used to make dyes and also used in the pharmaceutical industry. (chemenu.com)
  • Due to its DNA-intercalating properties, acridine or its suitable derivatives are expected to preferentially accumulate in tumors, which are always associated with enhanced DNA replication. (chemenu.com)
  • Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity. (unich.it)
  • To identify novel derivatives with higher neuroprotective activity, we evaluated the effects of a small library of acridine derivatives. (unich.it)
  • The 6-chloro-2-methoxyacridine derivatives bearing on position 9 a quinolizidin-1-ylamino (Q1, Q2) or a quinolizidin-1-ylalkylamino residue (Q3, Q4, Q6, Q7), the thio-bioisoster of Q3 (Q5), the 9-(N-lupinylthiopropyl)amino derivative (Q8) and simple acridines (Q9 and Q10) were considered. (unich.it)
  • All acridine derivatives analyzed showed high affinity binding for hPrP90-231, but only Q3 and Q10, caused a significant reduction of hPrP90-231 cytotoxicity, with higher efficacy than quinacrine. (unich.it)
  • A series of 8 new derivatives of fendiline was prepared for evaluation as allosteric modulators of GABA_B receptors: 4 based on acridine and 4 with restricted distance between the 2 aryl moieties. (tubitak.gov.tr)
  • Acridine chemiluminescence reagents mainly include acridine ester and acridine sulfonamide. (vacutaineradditives.com)
  • In addition, the chemiluminescence reagents of acridine ester series have very good stability and convenient storage. (vacutaineradditives.com)
  • For the shortcomings of this method, such as difficult reaction steps, high cost of raw materials and reagents, which is not conducive to large-scale preparation, the traditional seven step method is optimized, and a new five step chemical reaction method for the synthesis of acridine salt is developed. (vacutaineradditives.com)
  • Circular dichroism data also quantified the α-helicity change in hemoglobin due to the binding of acridine dyes. (jascoinc.com)
  • At present, there are many processes for the synthesis of acridine ester dmae-nhs, which can be attributed to the seven step method. (vacutaineradditives.com)
  • that pyrazolo[4,3-a]acridines with R=propyl, butyl, isobutyl and R'=chlorine substituents have suitable thermodynamic and binding parameters with HSA. (ac.ir)
  • other: Acridine 6-chloro-9-(3-((2-chloroethyl)amino) propyl)amino-2-methoxy dihydrochloride ( S. typh. (europa.eu)
  • In addition, acridine-9-carboraldehyde was synergistic to both rifampicin and levofloxacin with a fractional inhibitory concentration index of ≤ 0.5. (fortunejournals.com)
  • Roth D, London M. Acridine probe study into synergistic DNA-denaturing action of heat and ultraviolet light in squamous cells. (medscape.com)
  • Resazurin reduction microplate assay (REMA) was used to determine the minimum inhibitory concentrations of acridine-9-carboral-dehyde and 9-hydroxy-4-methoxy acridine as well as their interactions with conventional anti-TB drugs ie isoniazid, rifampicin and ciprofloxacin. (fortunejournals.com)
  • Acridine-9-carboraldehyde was active on both susceptible and multidrug-resistant strains of TB with minimum inhibitory concentrations of 0.238µg/mL and 0.108 µg/mL on the pan-sensitive and clinical susceptible strains and 0.157 µg/mL and 0.196 µg/mL on the rifampicin resistant and multidrug-resistant strains respectively. (fortunejournals.com)
  • Concentrations of acridine from emissions in urethane molds were the highest, 25 micrograms per gram (microg/g), 13microg/g in furan molds, and 37.7microg/g in green sand. (cdc.gov)
  • Acridines are organic compounds and nitrogen heterocycles having the formula C13H9N. (chemenu.com)
  • These data represent interesting leads for further modifications of the basic side chain and the substituent pattern of the acridine nucleus to develop novel compounds with improved antiprion activity to be tested in in vivo experimental setting. (unich.it)
  • Compounds that include the structure of acridine. (bvsalud.org)
  • Neo-acridine was a potent inhibitor of HIV-1 Rev-Response Element (RRE) binding showing a two order of magnitude higher affinity for RRE than that of the parent neomycin B. It appears that neo-acridine is the strongest competitive inhibitor of Rev-RRE binding. (bioorganic-chemistry.com)
  • The affinity of neo-acridine to the RRE is only 2-fold lower than that of the Rev peptide. (bioorganic-chemistry.com)
  • Acridine is a substituted derivative of the parent ring. (chemenu.com)
  • Overall, the results revealed that a small change in the acridine chromophore leads to remarkable alteration in the structural and thermodynamic aspects of binding to HHb. (jascoinc.com)
  • Acridine ester dmae-nhs was synthesized from 3,5-dimethyl-4-hydroxybenzoic acid and acridine 9 carboxylic acid through five steps of esterification, condensation, hydrolysis, succinyl amination and methylation. (vacutaineradditives.com)
  • i) to determine the antimycobacterial activity of two synthetic alkaloids i.e., acridine-9-carboraldehyde and 9-hydroxy-4-methoxy acridine on both susceptible and multidrug-resistant TB clinical isolates and ii) to determine interactions between the alkaloids and anti-TB drugs iii) to determine the toxicity profile of the most active alkaloid. (fortunejournals.com)
  • Based on the above understanding, the synthetic method and evolutionary history of acridine salt dmae-nhs. (vacutaineradditives.com)
  • In addition, the chemiluminescence process of acridine ester reacts rapidly and has low background. (vacutaineradditives.com)
  • Among them, acridine ester series has many models: acridine ester (dmae-nhs, nsp-dmae-nhs, me-dmae-nhs), acridine salt (nsp-sa, nsp-sa-nhs), acridine hydrazide nsp-sa-adh and other products. (vacutaineradditives.com)
  • Acridine-9-carboraldehyde is active against clinical isolates of multidrug-resistant M. tuberculosis. (fortunejournals.com)
  • Acridine ester is a very important chemiluminescence reagent with high quantum yield. (vacutaineradditives.com)
  • The chemiluminescence efficiency of acridine ester is relatively high, which is generally five times or more than five times that of luminol. (vacutaineradditives.com)
  • In recent years, with the development of chemiluminescence application technology and instruments, especially the expanded application of acridine ester series products, it has a very significant effect. (vacutaineradditives.com)