Acquired immunodeficiency syndrome. Medical search

An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.

Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas.

A characteristic symptom complex.

The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.

Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).

Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.

Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.

Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS.

A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.

Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

Acquired defect of cellular immunity that occurs in cats infected with feline immunodeficiency virus (FIV) and in some cats infected with feline leukemia virus (FeLV).

A species of LENTIVIRUS, subgenus feline lentiviruses (LENTIVIRUSES, FELINE) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There are 3 strains: Petaluma (FIP-P), Oma (FIP-O) and Puma lentivirus (PLV). There is no antigenic relationship between FIV and HIV, nor does FIV grow in human T-cells.

The sexual attraction or relationship between members of the same SEX.

Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).

Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV).

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.

Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.

The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.

A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.

Antibodies reactive with HIV ANTIGENS.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.

Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens.

Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.

An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian Lentivirus SIMIAN IMMUNODEFICIENCY VIRUS and infects only T4-lymphocytes expressing the CD4 phenotypic marker.

A genus in the family RETROVIRIDAE consisting of exogenous horizontally-transmitted viruses found in a few groups of mammals. Infections caused by these viruses include human B- or adult T-cell leukemia/lymphoma (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), and bovine leukemia (ENZOOTIC BOVINE LEUKOSIS). The type species is LEUKEMIA VIRUS, BOVINE.

External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.

A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.

A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.

A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.

Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.

Ribonucleic acid that makes up the genetic material of viruses.

The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.

Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.

An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Deoxyribonucleic acid that makes up the genetic material of viruses.

Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Established cell cultures that have the potential to propagate indefinitely.

Virus diseases caused by the RETROVIRIDAE.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Infections of the BRAIN caused by the protozoan TOXOPLASMA gondii that primarily arise in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES (see also AIDS-RELATED OPPORTUNISTIC INFECTIONS). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include SEIZURES, altered mentation, headache, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3)

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease.

Proteins encoded by the NEF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.

Proteins from the family Retroviridae. The most frequently encountered member of this family is the Rous sarcoma virus protein.

Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS.

Immune status consisting of non-production of HIV antibodies, as determined by various serological tests.

Immunologic tests for identification of HIV (HTLV-III/LAV) antibodies. They include assays for HIV SEROPOSITIVITY and HIV SERONEGATIVITY that have been developed for screening persons carrying the viral antibody from patients with overt symptoms of AIDS or AIDS-RELATED COMPLEX.

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Proteins encoded by the GAG GENE of the HUMAN IMMUNODEFICIENCY VIRUS.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Abuse, overuse, or misuse of a substance by its injection into a vein.

A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)

Studies of the number of cases where human immunodeficiency virus (HIV) is present in a specific population at a designated time. The presence in a given individual is determined by the finding of HIV antibodies in the serum (HIV SEROPOSITIVITY).

CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells.

Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

Inhibitors of HIV PROTEASE, an enzyme required for production of proteins needed for viral assembly.

An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.

Immunoglobulins produced in response to VIRAL ANTIGENS.

Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.

Regulatory sequences important for viral replication that are located on each end of the HIV genome. The LTR includes the HIV ENHANCER, promoter, and other sequences. Specific regions in the LTR include the negative regulatory element (NRE), NF-kappa B binding sites , Sp1 binding sites, TATA BOX, and trans-acting responsive element (TAR). The binding of both cellular and viral proteins to these regions regulates HIV transcription.

Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.

Proteins encoded by the REV GENES of the HUMAN IMMUNODEFICIENCY VIRUS.

Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.

A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.

Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. Proviruses are often associated with neoplastic cell transformation and are key features of retrovirus biology.

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.

A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.

A nontuberculous infection when occurring in humans. It is characterized by pulmonary disease, lymphadenitis in children, and systemic disease in AIDS patients. Mycobacterium avium-intracellulare infection of birds and swine results in tuberculosis.

Elements of limited time intervals, contributing to particular results or situations.

Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. It has a molecular weight of 41,000 and is glycosylated. The N-terminal part of gp41 is thought to be involved in CELL FUSION with the CD4 ANTIGENS of T4 LYMPHOCYTES, leading to syncytial formation. Gp41 is one of the most common HIV antigens detected by IMMUNOBLOTTING.

Contraceptive devices used by males.

DNA sequences that form the coding region for the viral envelope (env) proteins in retroviruses. The env genes contain a cis-acting RNA target sequence for the rev protein (= GENE PRODUCTS, REV), termed the rev-responsive element (RRE).

The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.

Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.

Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. It is worldwide in distribution and particularly common in the midwestern United States. (From Dorland, 27th ed)

The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).

Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2.

Enzyme of the human immunodeficiency virus that is required for post-translational cleavage of gag and gag-pol precursor polyproteins into functional products needed for viral assembly. HIV protease is an aspartic protease encoded by the amino terminus of the pol gene.

Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.

Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.

Proteins encoded by the VPR GENES of the HUMAN IMMUNODEFICIENCY VIRUS.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Sexual activities of humans.

A complex that includes several strains of M. avium. M. intracellulare is not easily distinguished from M. avium and therefore is included in the complex. These organisms are most frequently found in pulmonary secretions from persons with a tuberculous-like mycobacteriosis. Strains of this complex have also been associated with childhood lymphadenitis and AIDS; M. avium alone causes tuberculosis in a variety of birds and other animals, including pigs.

Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.

An envelope protein of the human immunodeficiency virus that is encoded by the HIV env gene. It has a molecular weight of 160,000 kDa and contains numerous glycosylation sites. It serves as a precursor for both the HIV ENVELOPE PROTEIN GP120 and the HIV ENVELOPE PROTEIN GP41.

A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of 16 species inhabiting forests of Africa, Asia, and the islands of Borneo, Philippines, and Celebes.

Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.

White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.

The transmission of infectious disease or pathogens from one generation to another. It includes transmission in utero or intrapartum by exposure to blood and secretions, and postpartum exposure via breastfeeding.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)

Proteins encoded by the ENV GENE of the HUMAN IMMUNODEFICIENCY VIRUS.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

DNA sequences that form the coding region for proteins associated with the viral core in retroviruses. gag is short for group-specific antigen.

The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

A genus of ascomycetous FUNGI, family Pneumocystidaceae, order Pneumocystidales. It includes various host-specific species causing PNEUMOCYSTIS PNEUMONIA in humans and other MAMMALS.

This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.

The type species of LENTIVIRUS, subgenus bovine lentiviruses (LENTIVIRUSES, BOVINE), found in cattle and causing lymphadenopathy, LYMPHOCYTOSIS, central nervous system lesions, progressive weakness, and emaciation. It has immunological cross-reactivity with other lentiviruses including HIV.

An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.

The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

The presence of viruses in the blood.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.

Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Involuntary weight loss of greater than 10 percent associated with intermittent or constant fever and chronic diarrhea or fatigue for more than 30 days in the absence of a defined cause other than HIV infection. A constant feature is major muscle wasting with scattered myofiber degeneration. A variety of etiologies, which vary among patients, contributes to this syndrome. (From Harrison's Principles of Internal Medicine, 13th ed, p1611).

CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)

A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.

Therapy with two or more separate preparations given for a combined effect.

A species of the genus MACACA which inhabits Malaya, Sumatra, and Borneo. It is one of the most arboreal species of Macaca. The tail is short and untwisted.

Inflammation of ARTERIES in the CENTRAL NERVOUS SYSTEM that occurs in patients with ACQUIRED IMMUNODEFICIENCY SYNDROME or AIDS-RELATED OPPORTUNISTIC INFECTIONS.

The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.

Trans-acting nuclear proteins whose functional expression are required for retroviral replication. Specifically, the rev gene products are required for processing and translation of the gag and env mRNAs, and thus rev regulates the expression of the viral structural proteins. rev can also regulate viral regulatory proteins. A cis-acting antirepression sequence (CAR) in env, also known as the rev-responsive element (RRE), is responsive to the rev gene product. rev is short for regulator of virion.

Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).

Agents used to treat RETROVIRIDAE INFECTIONS.

Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.

An alkylamino-alcohol complex of inosine used in the treatment of a variety of viral infections. Unlike other antiviral agents, it acts by modifying or stimulating cell-mediated immune processes rather than acting on the virus directly.

Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.

Classes of retroviruses for which monkeys or apes are hosts. Those isolated from the West African green monkey and the Asian rhesus macaque monkey are of particular interest because of their similarities to viruses causing cancer and acquired immunodeficiency syndrome (AIDS) in humans.

Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.

Proteins encoded by the VIF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.

Antibodies produced by a single clone of cells.

An infant during the first month after birth.

An agency of the UNITED STATES PUBLIC HEALTH SERVICE that conducts and supports programs for the prevention and control of disease and provides consultation and assistance to health departments and other countries.

Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)

Infections with bacteria of the genus MYCOBACTERIUM.

Proteins prepared by recombinant DNA technology.

The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.

Intestinal infection with organisms of the genus CRYPTOSPORIDIUM. It occurs in both animals and humans. Symptoms include severe DIARRHEA.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Conditions resulting from abnormalities in the arteries branching from the ASCENDING AORTA, the curved portion of the aorta. These syndromes are results of occlusion or abnormal blood flow to the head-neck or arm region leading to neurological defects and weakness in an arm. These syndromes are associated with vascular malformations; ATHEROSCLEROSIS; TRAUMA; and blood clots.

The acquired form of infection by Toxoplasma gondii in animals and man.

Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.

Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

Cellular receptors that bind the human immunodeficiency virus that causes AIDS. Included are CD4 ANTIGENS, found on T4 lymphocytes, and monocytes/macrophages, which bind to the HIV ENVELOPE PROTEIN GP120.

Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.

DNA sequences that form the coding region for a protein that down-regulates the expression of human immunodeficiency virus (HIV). nef is short for negative factor.

Trans-acting proteins which accelerate retroviral virus replication. The vpr proteins act in trans to increase the levels of specified proteins. vpr is short for viral protein R, where R is undefined.

Infection with a fungus of the species CRYPTOCOCCUS NEOFORMANS.

Persons who have experienced prolonged survival of HIV infection. This includes the full spectrum of untreated, HIV-infected long-term asymptomatics to those with AIDS who have survived due to successful treatment.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

DNA sequences that form the coding region for the protein responsible for trans-activation of transcription (tat) in human immunodeficiency virus (HIV).

A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.

Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.

The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.

Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Advice and support given to individuals to help them understand and resolve their sexual adjustment problems. It excludes treatment for PSYCHOSEXUAL DISORDERS or PSYCHOSEXUAL DYSFUNCTION.

A disorder of cognition characterized by the tetrad of finger agnosia, dysgraphia, DYSCALCULIA, and right-left disorientation. The syndrome may be developmental or acquired. Acquired Gerstmann syndrome is associated with lesions in the dominant (usually left) PARIETAL LOBE which involve the angular gyrus or subjacent white matter. (From Adams et al., Principles of Neurology, 6th ed, p457)

Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Vaccines or candidate vaccines designed to prevent SAIDS; (SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME); and containing inactivated SIMIAN IMMUNODEFICIENCY VIRUS or type D retroviruses or some of their component antigens.

Congenital syndrome characterized by a wide spectrum of characteristics including the absence of the THYMUS and PARATHYROID GLANDS resulting in T-cell immunodeficiency, HYPOCALCEMIA, defects in the outflow tract of the heart, and craniofacial anomalies.

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

A republic in the Greater Antilles in the West Indies. Its capital is Port-au-Prince. With the Dominican Republic it forms the island of Hispaniola - Haiti occupying the western third and the Dominican Republic, the eastern two thirds. Haiti belonged to France from 1697 until its rule was challenged by slave insurrections from 1791. It became a republic in 1820. It was virtually an American protectorate from 1915 to 1934. It adopted its present constitution in 1964 and amended it in 1971. The name may represent either of two Caribbean words, haiti, mountain land, or jhaiti, nest. (From Webster's New Geographical Dictionary, 1988, p481 & Room, Brewer's Dictionary of Names, 1992, p225)

A species of GAMMARETROVIRUS causing leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats. Several cellular oncogenes confer on FeLV the ability to induce sarcomas (see also SARCOMA VIRUSES, FELINE).

Sexual attraction or relationship between males.

A republic in central Africa, east of the REPUBLIC OF THE CONGO, south of the CENTRAL AFRICAN REPUBLIC and north of ANGOLA and ZAMBIA. The capital is Kinshasa.

An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.

A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.

Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.

An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.

Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.

An X-linked hyper-IgM immunodeficiency subtype resulting from mutation in the gene encoding CD40 LIGAND.

Genotypic differences observed among individuals in a population.

DNA sequences that form the coding region for a protein that regulates the expression of the viral structural and regulatory proteins in human immunodeficiency virus (HIV). rev is short for regulator of virion.

Enlargement of the spleen.

Dysregulated production of interleukin-8 in individuals infected with human immunodeficiency virus type 1 and Mycobacterium tuberculosis. (1/6107)

Interleukin-8 (IL-8) production in vivo was monitored in four study groups: normal blood donors, patients with pulmonary tuberculosis (TB), patients with human immunodeficiency virus type 1 (HIV-1) infection, and dually infected (HIV/TB) patients. We show that whereas there was evidence of detectable levels of cell-associated IL-8 (mRNA and protein) in peripheral cells of healthy individuals, this was largely lost in the disease states studied. Coupled with this finding was significantly increased circulating levels of IL-8 in HIV-1-infected individuals with or without concomitant pulmonary TB (P < 0.001). On the other hand, the capacity of peripheral mononuclear cells to produce IL-8 spontaneously ex vivo was enhanced in HIV-1 and TB patients (P < 0.05) and many of the HIV/TB group, but their corresponding capacities to respond to various stimuli, in particular phytohemagglutinin, were significantly diminished compared to those of normal donors (P < 0.05). Circulating levels of IL-8 in a group of HIV/TB patients were significantly positively correlated with the percentage of polymorphonuclear leukocytes (PMN) in the peripheral circulation (r = 0.65; P = 0.01), the proportions of IL-8 receptor A (IL-8RA)-expressing (r = 0.86; P < 0.01) and IL-8RB-expressing (r = 0.77; P < 0.01) PMN, and the capacity of PMN to migrate in response to IL-8 as chemoattractant (r = 0.68; P < 0. 01). IL-8RB fluorescence intensity, however, was negatively correlated with plasma IL-8 levels (r = -0.73; P < 0.01). Our results suggest that altered regulation of IL-8 in HIV-1 may have important implications for antimicrobial defenses and for normal immune processes. (+info)

Incidence and duration of hospitalizations among persons with AIDS: an event history approach. (2/6107)

OBJECTIVE: To analyze hospitalization patterns of persons with AIDS (PWAs) in a multi-state/multi-episode continuous time duration framework. DATA SOURCES: PWAs on Medicaid identified through a match between the state's AIDS Registry and Medicaid eligibility files; hospital admission and discharge dates identified through Medicaid claims. STUDY DESIGN: Using a Weibull event history framework, we model the hazard of transition between hospitalized and community spells, incorporating the competing risk of death in each of these states. Simulations are used to translate these parameters into readily interpretable estimates of length of stay, the probability that a hospitalization will end in death, and the probability that a nonhospitalized person will be hospitalized within 90 days. PRINCIPAL FINDINGS: In multivariate analyses, participation in a Medicaid waiver program offering case management and home care was associated with hospital stays 1.3 days shorter than for nonparticipants. African American race and Hispanic ethnicity were associated with hospital stays 1.2 days and 1.0 day longer than for non-Hispanic whites; African Americans also experienced more frequent hospital admissions. Residents of the high-HIV-prevalence area of the state had more frequent admissions and stays two days longer than those residing elsewhere in the state. Older PWAs experienced less frequent hospital admissions but longer stays, with hospitalizations of 55-year-olds lasting 8.25 days longer than those of 25-year-olds. CONCLUSIONS: Much socioeconomic and geographic variability exists both in the incidence and in the duration of hospitalization among persons with AIDS in New Jersey. Event history analysis provides a useful statistical framework for analysis of these variations, deals appropriately with data in which duration of observation varies from individual to individual, and permits the competing risk of death to be incorporated into the model. Transition models of this type have broad applicability in modeling the risk and duration of hospitalization in chronic illnesses. (+info)

Relative rates of AIDS among racial/ethnic groups by exposure categories. (3/6107)

The relative rates of acquired immunodeficiency syndrome (AIDS) were calculated among racial/ethnic populations using Centers for Disease Control and Prevention HIV (human immunodeficiency virus)/Surveillance reports assuming that racial/ethnic distributions reflect that of the US Census Data from 1990. For comparison, a rate of 1 was assigned to whites in each calculation. The overall relative rates were whites--1, African Americans--4.7, Hispanics--3, Asian/Pacific Islanders--0.4, and Native Americans--0.5. Acquired immunodeficiency syndrome surveillance data show higher rates of AIDS for African Americans and Hispanics compared with whites, Asians/Pacific Islanders, and Native Americans. The relative rates for African Americans and Hispanics compared with whites were highest for injecting drug users, heterosexual contact, and pediatric patients. These results led us to explore possible explanations for increased AIDS reporting in African Americans and Hispanics. We then explored available national datasets regarding those variables. The analyses indicate that variables such as access and receptivity to HIV prevention and treatment efforts, race/ethnicity, sexual behaviors, sexually transmitted diseases, socioeconomic status, and substance abuse interact in a complex fashion to influence HIV transmission and progression to AIDS in affected communities. (+info)

Outcome and predictors of failure of highly active antiretroviral therapy: one-year follow-up of a cohort of human immunodeficiency virus type 1-infected persons. (4/6107)

The outcome and predictors of virologic treatment failure of highly active antiretroviral therapy (HAART) were determined for 271 human immunodeficiency virus (HIV)-infected protease inhibitor-naive persons. During a follow-up of 48 weeks after the initiation of HAART, 6.3% of patients experienced at least one new AIDS-defining event, and 3.0% died. Virologic treatment failure occurred in 40% (indinavir, 27%; ritonavir, 30%; saquinavir, 59%; ritonavir plus saquinavir, 32%; chi2, P=.001). Risk factors for treatment failure were baseline plasma HIV-1 RNA (odds ratio [OR], 1.70 per log10 copies increase in plasma HIV-1 RNA), baseline CD4 cell count (OR, 1. 35 per 100 CD4 cells/mm3 decrease), and use of saquinavir versus other protease inhibitors (OR, 3.21). During the first year of treatment, 53% of all patients changed (part of) their original HAART regimen at least once. This was significantly more frequent for regimens containing saquinavir (62%; 27% for virologic failure) or ritonavir (64%; 55% for intolerance) as single protease inhibitor. (+info)

Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. (5/6107)

Biphasic plasma viral decays were modeled in 48 patients treated with ritonavir, zidovudine, and lamivudine. Estimated first- and second-phase decay rates were d1 as 0.47/day and d2 as 0.04/day. Interpatient differences in both decay rates were significant. The d1 was directly correlated with baseline CD4+, CD4+CD28+, and CD8+CD28+ T lymphocyte counts (P<.05) and inversely correlated with baseline virus load (P=.044) and the magnitude of CD4+ and CD8+ T lymphocyte recovery (P<.01). The d2 was directly correlated with baseline percentage of CD8+ T lymphocytes (P=.023), the CD8+CD38+ cell number (P=.024), and the level of IgG that binds to human immunodeficiency virus (HIV) type 1 gp120 (P=.02). Viral decay rates were not predictive of treatment failure or durability of viral suppression. These exploratory findings are consistent with a model in which immunologic factors contribute to elimination of HIV-infected cells and suggest a dynamic interplay between regulation of HIV expression and lymphocyte activation and recovery. (+info)

Proliferative responses to human immunodeficiency virus type 1 (HIV-1) gp120 peptides in HIV-1-infected individuals immunized with HIV-1 rgp120 or rgp160 compared with nonimmunized and uninfected controls. (6/6107)

The proliferative responses to a series of peptides constituting the human immunodeficiency virus type 1 (HIV-1) gp120 sequence were evaluated in 19 HIV-1-infected rgp160 vaccine recipients, 17 HIV-1-infected rgp120 vaccine recipients, 15 HIV-1-infected placebo recipients, and 18 HIV-1-uninfected controls. Many regions of the gp120 molecule were found to contribute proliferative epitopes, although there were clearly regions of relative dominance and silence. Vaccine recipients tended to have broader, more robust, and more frequent peptide recognition than the placebo recipients. Despite the considerable variability in the pattern of peptide recognition among individuals, there was a striking similarity between the rgp160 and rgp120 vaccinee groups as a whole. Low-risk HIV-1-uninfected individuals may react to a few peptides within the gp120 sequence as well, despite a lack of significant response to the whole gp120 protein. (+info)

No evidence for an effect of the CCR5 delta32/+ and CCR2b 64I/+ mutations on human immunodeficiency virus (HIV)-1 disease progression among HIV-1-infected injecting drug users. (7/6107)

The relationship between CCR5 and CCR2b genotypes and human immunodeficiency virus (HIV)-1 disease progression was studied among the 108 seroconverters of the Amsterdam cohort of injecting drug users (IDUs). In contrast to earlier studies among homosexual men, no effect on disease progression of the CCR5 Delta32/+ and the CCR2b 64I/+ genotypes was found, when progression to AIDS, death, or a CD4 cell count <200/microL was compared by a Cox proportional hazards model. Furthermore, CD4 cell decline (by a regression model for repeated measurements) and virus load in the first 3 years after seroconversion did not differ between the CCR5 and CCR2b wild type and heterozygous genotypes. A nested matched case-control study also revealed no significant effect of the CCR5 and CCR2b mutations. Immunologic differences between IDUs and homosexual men may account for the observed lack of effect. Alternatively, difference in transmission route or characteristics of the HIV-1 variants that circulate in IDUs could also explain this phenomenon. (+info)

A randomized trial of high- versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection. (8/6107)

Forty-nine outpatients infected with human immunodeficiency virus with baseline CD4 cell counts >/=500/mm3, who were on stable antiretroviral therapy, were randomized to receive 5-day cycles of either low-dose (1.5 million IU [MIU] twice a day) or high-dose (7.5 MIU twice a day) subcutaneous (sc) interleukin (IL)-2 every 4 or every 8 weeks. High-dose recipients experienced mean slopes of +116.1 cells/month and +2.7 %/month in CD4 cells and percents, respectively, whereas low-dose recipients displayed mean slopes of +26.7 and +1.3% in the same parameters. At month 6, high-dose recipients achieved a 94.8% increase in mean CD4 cells over baseline compared with a 19.0% increase in low-dose recipients. While high-dose recipients encountered more constitutional side effects, these were generally not dose-limiting. High-dose scIL-2 therapy in outpatients with early HIV-1 infection was well tolerated and induced dramatic, sustained rises in CD4 cells. (+info)

Endocrine complications of the Acquired Immunodeficiency Syndrome. Archives of Internal Medicine, 1991; 151:1441-1444. A. Levin ... activation with cellular viremia and plasma HIV RNA levels in asymptomatic patients infected by human immunodeficiency virus ...

https://en.wikipedia.org/wiki/Ken_Strauss

Chiao EY, Krown SE (September 2003). "Update on non-acquired immunodeficiency syndrome-defining malignancies". Current Opinion ... Some genetic syndromes[26] including congenital melanocytic nevi syndrome which is characterized by the presence of nevi ( ...

https://en.wikipedia.org/wiki/Skin_cancer

Acquired Immunodeficiency Syndrome atau Acquired Immune Deficiency Syndrome (disingkat AIDS) adalah sekumpulan gejala dan ... AIDS: Acquired immune deficiency syndrome. HIV: Human immunodeficiency virus. CD4+: Sel T pembantu CCR5: Chemokine (C-C motif) ... Acquired immunodeficiency syndrome (AIDS). Pita Merah terlipat adalah simbol solidaritas orang-orang yang positif terinfeksi ... "Hypothyroxinemia in acquired immune deficiency syndrome (AIDS)". Department of Radiation Medicine, University of Nigeria ...

https://id.wikipedia.org/wiki/AIDS

Gowda VK, Sukanya V (November 2012). "Acquired immunodeficiency syndrome with subacute sclerosing panencephalitis". Pediatric ... Measles had not been seen on the islands for 60 years, so almost no residents had any acquired immunity. Three-quarters of the ... Reye's Syndrome at NINDS "Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for ... The suggestion of a defined cause-effect relationship between aspirin intake and Reye syndrome in children is not supported by ...

https://en.wikipedia.org/wiki/Measles

"Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Council of State and Territorial ... Genetic diseases, like Klinefelter's syndrome, Chédiak-Higashi syndrome, ataxia telangiectasia syndrome. *Autoimmune diseases, ... like Sjögren's syndrome, celiac disease, rheumatoid arthritis, and systemic lupus erythematosus.[15][16] ...

https://en.wikipedia.org/wiki/Non-Hodgkin

"Prevention and control of acquired immunodeficiency syndrome (AIDS)". undocs.org. 1987-10-26. Retrieved 2019-07-30. Sakti, ...

https://en.wikipedia.org/wiki/National_AIDS_Commission_of_Indonesia

"Disseminated bilateral chorioretinitis due to Histoplasma capsulatum in a patient with the acquired immunodeficiency syndrome ... "Cutaneous histoplasmosis in patients with acquired immunodeficiency syndrome". Cutis. 72 (6): 439-45. PMID 14700213. James WD, ... Presumed ocular histoplasmosis syndrome causes chorioretinitis, where the choroid and retina of the eyes are scarred, resulting ... Distinct from POHS, acute ocular histoplasmosis may rarely occur in immunodeficiency. In absence of proper treatment and ...

https://en.wikipedia.org/wiki/Histoplasmosis

Heart problems are very important in people with Human Immunodeficiency Virus (HIV) as Acquired ImmunoDeficiency Syndrome (AIDS ... Cardiac involvement in the acquired immunodeficiency syndrome: a multicentre clinical-pathological study. AIDS Res Hum ... Cardiac involvement in the acquired immunodeficiency syndrome: a multicentre clinical-pathological study. AIDS Res Hum ... Cardiac involvement in the acquired immunodeficiency syndrome: a multicentre clinical-pathological study. AIDS Res Hum ...

https://en.wikipedia.org/wiki/HIV_associated_cardiomyopathy

May 1983). "Acquired immunodeficiency syndrome in a colony of macaque monkeys". Proceedings of the National Academy of Sciences ... King NW, Hunt RD, Letvin NL (December 1983). "Histopathologic changes in macaques with an acquired immunodeficiency syndrome ( ...

https://en.wikipedia.org/wiki/Zoonosis

Acquired Immune Deficiency Syndrome and Human Immunodeficiency Virus Infection". Texas Legislature. Retrieved 28 August 2018. " ... "15-716 - Instruction on acquired immune deficiency syndrome; department assistance". www.azleg.gov. "Arizona Governor Signs ...

https://en.wikipedia.org/wiki/Anti-LGBT_curriculum_laws_in_the_United_States

Gail MH, Brookmeyer R (August 1988). "Methods for projecting course of acquired immunodeficiency syndrome epidemic". Journal of ...

https://en.wikipedia.org/wiki/Adolescent_health

"Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic Considerations". Annals of Internal ... He became director of the NIAID in 1984 and has made contributions to HIV/AIDS research and other immunodeficiency diseases, ... Wikidata () Fauci, AS (February 5, 1988). "The human immunodeficiency virus: infectivity and mechanisms of pathogenesis". ... "The Immunopathogenesis of Human Immunodeficiency Virus Infection". New England Journal of Medicine. 328 (5): 327-335. doi: ...

https://en.wikipedia.org/wiki/Anthony_Fauci

"Acquired Immunodeficiency Syndrome in a Heterosexual Population in Zaire". The Lancet. 324 (8394): 65-69. doi:10.1016/S0140- ...

https://en.wikipedia.org/wiki/Project_SIDA

1984-07-14). "ACQUIRED IMMUNODEFICIENCY SYNDROME IN A HETEROSEXUAL POPULATION IN ZAIRE." The Lancet. Mann, Jonathan M., et al ... "Acquired Immunodeficiency Syndrome in a Heterosexual Population in Zaire". The Lancet. Originally published as Volume 2, Issue ... 1986-09-27). "NATURAL HISTORY OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN ZAIRE." The Lancet. Colebunders, Robert, et al. ( ... 1988-10-27). "Human Immunodeficiency Virus Infection among Employees in an African Hospital." New England Journal of Medicine. ...

https://en.wikipedia.org/wiki/Bila_M._Kapita

"Acanthamoeba meningoencephalitis in a patient with acquired immunodeficiency syndrome". Archives of Pathology & Laboratory ... Patients experiencing this particular syndrome may report a skin lesion (often similar to those caused by MRSA), which does not ...

https://en.wikipedia.org/wiki/Balamuthia_mandrillaris

"Current Trends First 100,000 Cases of Acquired Immunodeficiency Syndrome". www.cdc.gov. Centers for Disease Control. Retrieved ... To ensure that the United States acquired the maximum benefit from automated innovation, Reagan, during his second term, had an ... he acquired the lifelong nickname "the Gipper". In 1941, exhibitors voted him the fifth most popular star from the younger ...

https://en.wikipedia.org/wiki/Ronald_Reagan

Horsburgh CR (May 1991). "Mycobacterium avium complex infection in the acquired immunodeficiency syndrome". N. Engl. J. Med. ... They proposed this syndrome be named Lady Windermere syndrome, after the character Lady Windermere in Oscar Wilde's play Lady ... "Lady Windermere syndrome" is one term to describe infection in the lungs due to MAC. It is named after a character in Oscar ... Immunodeficiency is not a requirement for MAI. MAC usually affects patients with abnormal lungs or bronchi. However, Jerome ...

https://en.wikipedia.org/wiki/Mycobacterium_avium-intracellulare_infection

"Acanthamoeba meningoencephalitis in a patient with acquired immunodeficiency syndrome". Archives of Pathology & Laboratory ... Pure granulomatous lesions are rare in patients with AIDS and other related immunodeficiency states, as the patients do not ... A perivascular cuffing with amoebae in necrotic tissue is usual finding in the AIDS and related T-cell immunodeficiency ... Infection is generally associated with underlying conditions such as immunodeficiency, diabetes, malignancies, malnutrition, ...

https://en.wikipedia.org/wiki/Acanthamoeba

"Eosinophilic pustular folliculitis in patients with acquired immunodeficiency syndrome". International Journal of Dermatology. ... Fearfield, LA; Rowe, A; Francis, N; Bunker, CB; Staughton, RC (1999). "Itchy folliculitis and human immunodeficiency virus ... "Metronidazole for eosinophilic pustular folliculitis in human immunodeficiency virus type 1-positive patients". Archives of ...

https://en.wikipedia.org/wiki/Eosinophilic_folliculitis

Acquired immunodeficiency syndrome in a colony of macaque monkeys. Proceedings of the National Academy of Sciences of the ... Histopathologic changes in macaques with an acquired immunodeficiency syndrome (AIDS). The American Journal of Pathology. 1983- ... 猴免疫缺陷病毒（英语：Simian immunodeficiency virus，简称SIV），也称为非洲绿猴病毒（英语：African Green Monkey virus），是一种可影响至少33种非洲灵长目的逆转录病毒。[1][2]在对比奥科岛（于大 ... That means humans have presumably

https://zh.wikipedia.org/wiki/猴免疫缺陷病毒

The human immunodeficiency virus can lead to acquired immune deficiency syndrome (AIDS). Untreated HIV infected expectant ... By the end of the tenth week of gestational age the embryo has acquired its basic form and is referred to as a fetus. The next ... There is a risk of Down syndrome for infants born to those aged over 40 years. Young teenaged mothers (younger than 16) and ... Alcohol, certain drugs, and other toxins that cause birth defects, such as fetal alcohol syndrome ...

https://en.wikipedia.org/wiki/Perinatal

Acquired immunodeficiency syndrome (AIDS) is a leading cause of death in the world. It was identified as a disease in 1981. Two ... are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT ...

https://en.wikipedia.org/wiki/Discovery_and_development_of_non-nucleoside_reverse-transcriptase_inhibitors

Bruce A. Chabner (April 13, 1982). "Kaposi's Sarcoma/Opportunistic Infections/Acquired Immunodeficiency Syndrome - U.S. ... The Acquired Immune Deficiency Syndrome amendments were compiled as Title II - Programs with Respect to Acquired Immune ... The Acquired Immune Deficiency Syndrome was officially recognized on June 5, 1981, when the U.S. Centers for Disease Control ... On April 13, 1982, the first U.S. congressional hearings were conducted on the Acquired Immune Deficiency Syndrome by U.S. ...

https://en.wikipedia.org/wiki/AIDS_amendments_of_1988

"Infection by the retrovirus associated with the acquired immunodeficiency syndrome". Annals of Internal Medicine. 103 (5): 694- ... "Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)". Science. 220 ( ... "Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)". Science. 220 (4599): 865-867. Bibcode: ...

https://en.wikipedia.org/wiki/List_of_multiple_discoveries

... ; Steven S Witkin; David T Purtilo (6 May 1983). "Acquired immunodeficiency syndrome, opportunistic infections ...

https://en.wikipedia.org/wiki/Joseph_Sonnabend

"Rapidly Progressive Outer Retinal Necrosis in the Acquired Immunodeficiency Syndrome". American Journal of Ophthalmology. 110 ( ... Researchers have also looked at two cases of ARN in patients who have been diagnosed with an immunodeficiency virus. The ... Researchers are now wondering if this type of ARN is specific to those who have the immunodeficiency virus. Cytomegalovirus ...

https://en.wikipedia.org/wiki/Acute_retinal_necrosis

Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system ... "Infection by the retrovirus associated with the acquired immunodeficiency syndrome". Annals of Internal Medicine. 103 (5): 694- ... Centers for Disease Control (1982). "Update on acquired immune deficiency syndrome (AIDS)-United States". Morbidity and ... Journal of Acquired Immune Deficiency Syndromes. 29 (2): 184-190. doi:10.1097/00042560-200202010-00013. PMID 11832690. S2CID ...

https://en.wikipedia.org/wiki/HIV

HIV leads to a syndrome called Acquired Immunodeficiency Syndrome, or AIDS. Treatments for HIV remained inaccessible to many ... A new viral disease, called the Human Immunodeficiency Virus, or HIV, arose in Africa and subsequently killed millions of ...

https://en.wikipedia.org/wiki/20th_century

"Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Council of State and Territorial ... Genetic diseases, like Klinefelter syndrome, Chédiak-Higashi syndrome, ataxia-telangiectasia syndrome. Autoimmune diseases, ... like Sjögren syndrome, celiac disease, rheumatoid arthritis, and systemic lupus erythematosus. Bone trauma and microfractures ...

https://en.wikipedia.org/wiki/Non-Hodgkin_lymphoma

The global human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) pandemic has been an important factor in ... candidiasis-endocrinopathy syndrome and candidiasis thymoma syndrome. About 90% of people with chronic mucocutaneous ... Candida species are acquired from the mother's vaginal canal during birth. At very young ages, the immune system is yet to ... Immunodeficiency is a state of reduced function of the immune system, which can be caused by medical conditions or treatments. ...

https://en.wikipedia.org/wiki/Oral_candidiasis

Transplant patients lose their acquired immunity, for example immunity to childhood diseases such as measles or polio. For this ... Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or ... Other conditions[13] treated with stem cell transplants include sickle-cell disease, myelodysplastic syndrome, neuroblastoma, ... and hepatic VOD has lately been referred to as sinusoidal obstruction syndrome (SOS). Severe cases of SOS are associated with a ...

https://en.wikipedia.org/wiki/Bone_Marrow_Transplant

ኤድስ (Acquired Immune Deficiency Syndrome / AIDS / ኣኳየርድ ኢምዩን ደፊሸንሲ ሲይንድሮም) በዓለም ላይ መሰራጨት እንደጀመረ ኤችኣይቪ (Human Immunodeficiency ...

https://am.wikipedia.org/wiki/ኣበራ_ሞላ

Job's Syndrome), DOCK8 (DOCK8 Immunodeficiency or DIDS), PGM3 (PGM3 deficiency), SPINK5 (Netherton Syndrome - NTS), and TYK2 ... "Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired ... Rapp-Hodgkin syndrome/Hay-Wells syndrome/Ectrodactyly-ectodermal dysplasia-cleft syndrome 3/Limb-mammary syndrome/OFC8 ... "hyperimmunoglobulinemia E syndrome" at Dorland's Medical Dictionary *^ Dermatologic Manifestations of Job Syndrome at eMedicine ...

https://en.wikipedia.org/wiki/Hyperimmunoglobulin_E_syndrome

Disseminated toxoplasmosis in a patient with advanced acquired immunodeficiency syndrome» (en anglès). Autops Case Rep, 2018 ... Herwaldt, BL «Laboratory-Acquired Parasitic Infections from Accidental Exposures» (en anglès). Clin Microbiol Rev, 2001 Oct; 14 ...

https://ca.wikipedia.org/wiki/Toxoplasma_gondii

... and human immunodeficiency virus/acquired immunodeficiency syndrome. Am J Trop Med Hyg 2004 ...

https://en.m.wikipedia.org/wiki/Developing_world

Other strains and novel pathological syndromes[edit]. Although JC virus infection is classically associated with white matter ... Since immunodeficiency causes this virus to progress to PML, immunosuppressants are contraindicated in those who are infected. ... The virus is very common in the general population, infecting 70% to 90% of humans; most people acquire JCV in childhood or ... Immunodeficiency or immunosuppression allows JCV to reactivate. In the brain, it causes the usually fatal progressive ...

https://en.wikipedia.org/wiki/Jc_virus

AACTG - acquired immunity - acquired immunodeficiency syndrome (AIDS) - ACT UP/Golden Gate - active immunity - acupuncture - ... division of acquired immunodeficiency syndrome (DAIDS) - DNA - Domain (biology) - dose-ranging study - dose-response ... human immunodeficiency virus type 1 (HIV-1) - human immunodeficiency virus type 2 (HIV-2) - human leukocyte antigens (HLA) - ... wasting syndrome - Western blot - white blood cells - wild-type virus - window period - Women's Interagency HIV Study (WIHS) - ...

https://en.m.wikipedia.org/wiki/Index_of_AIDS-related_topics

Wiskott-Aldrich syndrome, immunodeficiency with short-limbed dwarfism, immunodeficiency with thymoma, purine nucleoside ... Neutropenia can be acquired or intrinsic.[16] A decrease in levels of neutrophils on lab tests is due to either decreased ... Like neutropenia, lymphocytopenia may be acquired or intrinsic and there are many causes.[15] This is not a complete list. ... For example, the most common cause of acquired neutropenia is drug-induced, so an individual may have symptoms of medication ...

https://en.wikipedia.org/wiki/Immune_cell

... ataxia-like syndrome, Nijmegen breakage syndrome, Bloom syndrome DiGeorge syndrome (when associated with thymic defects) ... antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte ... Immunodeficiency with hypopigmentation or albinism: Chédiak-Higashi syndrome, Griscelli syndrome type 2 Familial hemophagocytic ... Neutrophil immunodeficiency syndrome) Beta-actin deficiency Localized juvenile periodontitis Papillon-Lefèvre syndrome Specific ...

https://en.wikipedia.org/wiki/Primary_immunodeficiency

F02.4) Dementia in human immunodeficiency virus (HIV) disease. *(F03) Unspecified dementia. *(F04) Organic amnesic syndrome, ... F80.3) Acquired aphasia with epilepsy (Landau-Kleffner). *(F80.8) Other developmental disorders of speech and language *Lisping ... Alcohol dependence syndrome Alcohol withdrawal syndrome Delirium tremens Alcoholic hallucinosis Korsakoff's syndrome ... F50-F59) Behavioural syndromes associated with physiological disturbances and physical factors[edit]. *(F50) Eating disorders * ...

https://en.wikipedia.org/wiki/ICD-10_Chapter_F

Guss DA (1994). "The acquired immune deficiency syndrome: an overview for the emergency physician, Part 1". J. Emerg. Med. 12 ( ... Tóth FD, Bácsi A, Beck Z, Szabó J (2001). "Vertical transmission of human immunodeficiency virus". Acta Microbiol Immunol Hung ... Guss DA (1994). "The acquired immune deficiency syndrome: an overview for the emergency physician, Part 2". J. Emerg. Med. 12 ( ... N'Galy B, Ryder RW (1988). "Epidemiology of HIV infection in Africa". Journal of Acquired Immune Deficiency Syndromes 1 (6): ...

https://ta.wikipedia.org/wiki/எய்ட்சு

"Adherence to antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency syndrome among drug users: a ... Guss DA (1994). "The acquired immune deficiency syndrome: an overview for the emergency physician, Part 1". J Emerg Med 12 (3 ... Centers for Disease Control (CDC) (1982). "Update on acquired immune deficiency syndrome (AIDS)-United States". MMWR Morb ... 1983). "Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)". ...

https://gl.m.wikipedia.org/wiki/Síndrome_de_inmunodeficiencia_adquirida

Etzioni, Amos; Ochs, Hans D. (2014). Primary Immunodeficiency Disorders: A Historic and Scientific Perspective. Oxford, UK: ... Virchow-Seckel syndrome, a very rare disease also known as "bird-headed dwarfism" ... He remarked that the movement was acquiring "the character of a great struggle in the interest of humanity". He called it ... Virchow discovered the clinical syndrome which he called ochronosis, a metabolic disorder in which a patient accumulates ...

https://en.m.wikipedia.org/wiki/Rudolf_Virchow

Wiskott-Aldrich syndrome. *Hyper-IgE syndrome. Other. *Common variable immunodeficiency. *ICF syndrome ...

https://en.wikipedia.org/wiki/Antibody-dependent_cellular_cytotoxicity

AIDS denialism is the denial that the human immunodeficiency virus (HIV) is the cause of acquired immune deficiency syndrome ( ... Journal of Acquired Immune Deficiency Syndromes. 49 (4): 410-415. doi:10.1097/QAI.0b013e31818a6cd5. PMID 19186354. Lay summary. ...

https://en.m.wikipedia.org/wiki/Denialism

... wujud akronim ing basa Inggris saka Acquired Immunodeficiency Syndrome utawa Acquired Immune Deficiency Syndrome ('sindrom ... dhéfisiènsi imun dapatan'). Jeneng virusé ya iku HIV, wujud singkatan saka Human Immunodeficiency Virus ('virus dhéfisiènsi ...

https://jv.wikipedia.org/wiki/AIDS

... is classified as either hereditary or acquired. Acquired angioedema[edit]. Acquired angioedema (AAE) can be ... Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. Aerosol burn. ... Immune disorders: Lymphoid and complement immunodeficiency (D80-D85, 279.0-4). Primary. Antibody/humoral. (B). ... Acquired[edit]. In acquired angioedema, HAE types I and II, and nonhistaminergic angioedema, antifibrinolytics such as ...

https://en.wikipedia.org/wiki/Angioneurotic_oedema

... "variants of a human cancer virus called HTLV-III are the primary cause of acquired immunodeficiency syndrome (AIDS)," a new ...

https://en.wikipedia.org/wiki/National_Institute_of_Health

The HIV virus causes an acquired T-cell immunodeficiency syndrome (AIDS) by specifically killing CD4+ T cells. Whereas the ... Severe combined immunodeficiency syndromes (SCID) are group of rare congenital genetic diseases that result in combined T ... Loss of the thymus at an early age through genetic mutation (as in DiGeorge Syndrome) results in severe immunodeficiency and ... Defects that affect both the T cell and B cell lymphocyte lineages result in severe combined immunodeficiency (SCID). Acquired ...

https://en.wikipedia.org/wiki/Thymus

"Lavender Foal Syndrome Fact Sheet". James A Baker Institute for Animal Health. Cornell University. Retrieved May 29, 2008.. ... Severe Combined Immunodeficiency (SCID). Recessive disorder, fatal when homozygous, carriers (heterozygotes) show no signs. ... Maynesboro and Kellogg bloodlines has acquired the copyrighted designation "CMK."[189] ... "Lavender Foal Syndrome". Texas Vet News. Veterinary Information Network. Retrieved November 24, 2006.. ...

https://en.m.wikipedia.org/wiki/Arabian_horse

... were infected with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). In the first half of 2005, ...

https://en.wikipedia.org/wiki/Health_in_Germany

Immunodeficiency and autoimmunity[edit]. There are a large number of immunodeficiency syndromes that present clinical and ... "for discovery of acquired immunological tolerance". ... Local syndromes which affect a specific organ or tissue: * ... Systemic autoimmune diseases include SLE, Sjögren's syndrome, sarcoidosis, scleroderma, rheumatoid arthritis, cryoglobulinemic ... Wiskott-Aldrich syndrome (WAS) patients also present with eczema, autoimmune manifestations, recurrent bacterial infections and ...

https://en.wikipedia.org/wiki/Autoimmune

The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes. Springer Science & Business ... Because the native Amerindian population had no acquired immunity to this new disease, their peoples were decimated by ... protein and electrolytes beyond the capacity of the body to replace or acquire, and fulminating sepsis.[59] ... Age distribution of smallpox infections depended on acquired immunity. Vaccination immunity declined over time and was probably ...

https://en.wikipedia.org/wiki/Smallpox

The first New York Times story on acquired immunodeficiency syndrome (AIDS) was published on July 3, 1981. In 1982 it was first ... In 1987, London Rubber began acquiring other condom manufacturers, and within a few years became an important international ...

https://en.wikipedia.org/wiki/History_of_condoms

In 2004, Solexa acquired the company Manteia Predictive Medicine in order to gain a massivelly parallel sequencing technology ... "Origins of the Strain Causing an Outbreak of Hemolytic-Uremic Syndrome in Germany". N Engl J Med. 365 (8): 709-17. doi:10.1056 ... "Comparison of Sequencing by Hybridization and Cycle Sequencing for Genotyping of Human Immunodeficiency Virus Type 1 Reverse ... A parallelized version of pyrosequencing was developed by 454 Life Sciences, which has since been acquired by Roche Diagnostics ...

https://en.wikipedia.org/wiki/Sequencing_technology

Chiao, EY; Krown, SE (September 2003). "Update on non-acquired immunodeficiency syndrome-defining malignancies". Current ...

https://or.wikipedia.org/wiki/ତ୍ୱକ_କର୍କଟ

Immunodeficiency. *Immunoproliferative immunoglobulin disorders. *Hypersensitivity and autoimmune disorders. *Neoplasms and ...

https://kn.wikipedia.org/wiki/ಟೆಂಪ್ಲೇಟು:Central_nervous_system_navs

Acquired immunodeficiency syndrome (AIDS). वर्गीकरण व पिनेयागु श्रोत The Red ribbon is a symbol for solidarity with HIV- ...

https://new.wikipedia.org/wiki/एड्स

Acquired Immunodeficiency Syndrome. Featured. In the 1980s, soon after AIDS and HIV were first recognized, RAND Health ... Acquired Immunodeficiency Syndrome. ... Acquired Immunodeficiency Syndrome; *Human Immunodeficiency ...

https://www.rand.org/topics/acquired-immunodeficiency-syndrome.html

Including Monitoring for Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome (https://www.cdc.gov/ ... Guidelines for National Human Immunodeficiency Virus Case Surveillance, ...

https://wwwn.cdc.gov/nndss/conditions/acquired-immunodeficiency-syndrome/

1990)‎. Acquired immunodeficiency syndrome-AIDS. https://apps.who.int/iris/handle/10665/121041 ...

https://apps.who.int/iris/handle/10665/121041

Tuberculosis and Acquired Immunodeficiency Syndrome -- New York City In recent years, reported tuberculosis (TB) cases in New ... Because the increased TB morbidity in NYC was concurrent with the acquired immunodeficiency syndrome (AIDS) epidemic and was ... Tuberculosis, atypical mycobacteriosis, and the acquired immuno- deficiency syndrome among Haitian and non-Haitian patients in ... Tuberculosis in patients with the acquired immuno- deficiency syndrome: clinical features, response to therapy, and survival. ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/00032067.htm

home/hiv health center/hiv a-z list/acquired immunodeficiency syndrome aids center /acquired immunodeficiency syndrome (aids) ... Human immunodeficiency virus causes HIV infection. Acquired immunodeficiency syndrome (AIDS) is a condition that results after ... AIDS stands for acquired immunodeficiency syndrome.. *AIDS is an advanced stage of infection with the human immunodeficiency ... Acronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). See a picture of HIV/AIDS ...

https://www.medicinenet.com/acquired_immunodeficiency_syndrome_aids/article.htm

Current Trends Update: Acquired Immunodeficiency Syndrome -- United States, 1994 During 1994, state, local, and territorial ... health departments reported to CDC 80,691 cases of acquired immunodeficiency syndrome (AIDS) among persons in the United States ... Of these, 39,513 (91%) persons had severe human immunodeficiency virus (HIV)-related immunodeficiency only (i.e., less than 200 ... heterosexually acquired AIDS. These persons are classified as no risk reported. @ Northeast=New England and Middle Atlantic ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/00035736.htm

1996)‎. Progress report on acquired immunodeficiency syndrome-AIDS. http://www.who.int/iris/handle/10665/121523 ...

https://apps.who.int/iris/handle/10665/121523

Acquired immunodeficiency syndrome (AIDS) is the most advanced stage of HIV infection. To be diagnosed with AIDS, a person with ... Acquired Immunodeficiency Syndrome (AIDS) Acquired Immunodeficiency Syndrome Speaker A disease of the immune system due to ... Acquired immunodeficiency syndrome (AIDS) is the most advanced stage of HIV infection. To be diagnosed with AIDS, a person with ... Related Term(s): Acute HIV Infection, AIDS Case Definition, Chronic HIV Infection, HIV Progression, Human Immunodeficiency ...

https://aidsinfo.nih.gov/understanding-hiv-aids/glossary/3/acquired-immunodeficiency-syndrome?ref=oceancitycool

The Division of Acquired Immunodeficiency Syndrome (DAIDS) is a division of the National Institute of Allergy and Infectious ...

https://en.wikipedia.org/wiki/Division_of_Acquired_Immunodeficiency_Syndrome

... MMWR 35(37);587-90 Publication date: 09/19/1986. Table of ... Revision of the case definition of acquired immunodeficiency syndrome for national reporting--United States. MMWR 1985;34:373-5 ... led to an evaluation of data on acquired immunodeficiency syndrome (AIDS) and tuberculosis. Four subgroups of persons were ... The radiographic appearance of tuberculosis in patients with the acquired immune deficiency syndrome (AIDS) and pre-AIDS. Am ...

https://wonder.cdc.gov/wonder/prevguid/m0000807/m0000807.asp

... is the last stage of infection with the human immunodeficiency virus (HIV). AIDS ... post a link to Acquired immunodeficiency syndrome (AIDS) information on Facebook. ... post a link to Acquired immunodeficiency syndrome (AIDS) information on Twitter. ... send a link to Acquired immunodeficiency syndrome (AIDS) information by email. ...

https://www.healthwise.net/ha2z/Content/StdDocument.aspx?DOCHWID=sta123131

Sjögrens syndrome-like illness associated with the acquired immunodeficiency syndrome-related complex.. Ulirsch RC1, Jaffe ES. ... Three cases of Sjögrens syndrome-like illness occurring in patients with the acquired immunodeficiency syndrome (AIDS)-related ... Atypical Sjögrens syndrome now requires evaluation for ARC. Proposed criteria for identifying these patients are as follows: 1 ... Positive serologic tests for the human immunodeficiency virus (HIV) were documented in two; the third patient was a prison ...

https://www.ncbi.nlm.nih.gov/pubmed/3653877?dopt=Abstract

The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immunodeficiency syndrome (AIDS).. ... Acquired Immunodeficiency Syndrome/complications*. *Acquired Immunodeficiency Syndrome/epidemiology. *Acquired Immunodeficiency ... We conclude that DNTM is acquired by unpreventable environmental exposures. Because DNTM adversely affects survival of AIDS ... of DNTM were lower in Hispanics and declined with age but were not significantly different by patient sex or means of acquiring ...

https://www.ncbi.nlm.nih.gov/pubmed/2912355?dopt=Abstract

Chronic Immune Activation Associated with Chronic Helminthic and Human Immunodeficiency Virus Infections: Role of ...

https://cmr.asm.org/keyword/acquired-immunodeficiency-syndrome

Acquired Immunodeficiency Syndrome (AIDS) is medically treatable and is not transmitted by casual contact, and employees with ... Human Immunodeficiency Virus (HIV) / Acquired Immunodeficiency Syndrome (AIDS). CAUT Policy Statement. Human Immunodeficiency ... Acquired Immunodeficiency Syndrome (AIDS) is medically treatable and is not transmitted by casual contact, and employees with ... CAUT Policy Statement Human Immunodeficiency Virus (HIV) / ...

https://www.caut.ca/about-us/caut-policy/lists/caut-policy-statements/policy-statement-on-human-immunodeficiency-virus-%28hiv%29-acquired-immunodeficiency-syndrome-%28aids%29

Another name for Acquired Immunodeficiency Syndrome is AIDS. Many patients with HIV infection and AIDS will suffer from ... Acquired Immunodeficiency Syndrome Anorexia. Many patients with HIV infection and AIDS will suffer from anorexia.. Anorexia is ... PubMed Acquired Immunodeficiency Syndrome References *Aberg JA, Gallant JE, Anderson J, et al: Primary care guidelines for the ... Continue to Acquired Immunodeficiency Syndrome Depression Last Updated: Nov 16, 2010 References Authors: Stephen J. Schueler, ...

http://www.freemd.com/acquired-immunodeficiency-syndrome/home-care-anorexia.htm

... ANSWER ... What are symptoms of human immunodeficiency virus (HIV)?. NEXT QUESTION: What infections and illnesses are related to acquired ... How can treatments help you deal with human immunodeficiency virus (HIV)?. *What are side effects of antiretroviral (ARV) in ... What should you do if you have side effects while taking antiretroviral (ARV) in your treatment for human immunodeficiency ...

https://www.webmd.com/hiv-aids/qa/what-are-signs-that-human-immunodeficiency-virus-hiv-is-turning-into-acquired-immune-deficiency-syndrome-aids

Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome. The safety and scientific ... Acquired Immunodeficiency Syndrome. HIV Infections. Leukoencephalopathy, Progressive Multifocal. Lentivirus Infections. ... in patients with acquired immunodeficiency syndrome (AIDS). PML is a life-threatening infection of the brain that affects about ... Immunologic Deficiency Syndromes. Immune System Diseases. Encephalitis, Viral. Central Nervous System Viral Diseases. ...

https://clinicaltrials.gov/show/NCT00342602?order=737

... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T ...

https://extranet.who.int/iris/restricted/handle/10665/164604/browse?authority=Acquired+Immunodeficiency+Syndrome&type=mesh

Lipodystrophy Syndrome Lipodystrophy syndrome is the abnormal distribution of fat in the ... ... Another name for Acquired Immunodeficiency Syndrome is AIDS. ... PubMed Acquired Immunodeficiency Syndrome References *Aberg JA ... Acquired Immunodeficiency Syndrome Lipodystrophy Syndrome. Lipodystrophy Syndrome. Lipodystrophy syndrome is the abnormal ... Continue to Acquired Immunodeficiency Syndrome Opportunistic Infections Last Updated: Nov 9, 2010 References Authors: Stephen J ...

http://www.freemd.com/acquired-immunodeficiency-syndrome/complications-lipodystrophy-syndrome.htm

Internal Medicine English Language Esophagitis Acquire Immunodeficiency Syndrome Immunosuppressed Patient This is a preview of ... Alvarez S: Systemic infection caused byPenicillium decumbens in a patient with acquired immunodeficiency syndrome. Journal of ... Groopman JE: The acquired immunodeficiency syndrome. In: Wyngaarden JB, Smith LH (ed): Cecil textbook of medicine. Saunders, ... Piehl MR, Kaplan RL, Haber MH: Disseminated penicilliosis in a patient with acquired immunodeficiency syndrome. Archives of ...

https://link.springer.com/article/10.1007/BF01961135

The association of Reiters Syndrome (RS) with the Acquired Immunodeficiency Syndrome (AIDS) is seldom mentioned in the medical ... The co-occurrence of Reiters Syndrome and Acquired Immunodeficiency. Ann Intern Med 1987;106:19-26. [ Links ]. 6. Medina- ... Males predominate at a 5:1 ratio [1,2]. The association between RS and the Acquired Immunodeficiency Syndrome (AIDS) was first ... Reiters syndrome and human immunodeficiency virus infection: case report and review of the literature. Cutis 1991;47(3):181-5 ...

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100006

What are the Acquired Immunodeficiency Syndrome symptoms? Is the suicide rate among people with Acquired Immunodeficiency ... Syndrome high? Get the answers by contacting Experts on JustAnswer. ... Acquired Immunodeficiency Syndrome Questions. What is Acquired Immunodeficiency Syndrome?. Acquired Immunodeficiency Syndrome ( ... Acquired Immunodeficiency Syndrome has impacted society with regards to an illness as well as a source of discrimination. This ...

https://www.justanswer.com/topics-aids/

We have examined 11 patients with the acquired immunodeficiency syndrome (AIDS) for evidence of subclinical vitamin B12 ... Vitamin B12 malabsorption in patients with acquired immunodeficiency syndrome Arch Intern Med. 1989 Sep;149(9):2039-41. ... We have examined 11 patients with the acquired immunodeficiency syndrome (AIDS) for evidence of subclinical vitamin B12 ... of 27 patients without AIDS who were seropositive for human immunodeficiency virus type 1 (HIV-1) had low serum vitamin B12 ...

https://pubmed.ncbi.nlm.nih.gov/2774781/?dopt=Abstract

... Mathews Elizabeth Sep/Oct 2000. 334. Buy. ... Taste of Antiretrovirals for Pediatric Patients Infected with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: ... Related Keywords: HIV, AIDS, immunodeficiency, immune system, viral, virus, opportunistic infections, infections, antiviral ...

http://www.ijpc.com/abstracts/abstract.cfm?ABS=1358

Acquired Immunodeficiency Syndrome and the Risk of Stroke. John W. Cole, Amelia N. Pinto, J. Richard Hebel, David W. Buchholz, ... Acquired Immunodeficiency Syndrome and the Risk of Stroke. John W. Cole, Amelia N. Pinto, J. Richard Hebel, David W. Buchholz, ... Acquired Immunodeficiency Syndrome and the Risk of Stroke. John W. Cole, Amelia N. Pinto, J. Richard Hebel, David W. Buchholz, ... Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome: MMWR Morb Mortal Wkly Rep. 1987; 36 ( ...

http://stroke.ahajournals.org/content/35/1/51

The possibility of deep vein thrombosis being a manifestation of the acquired immunodeficiency syndrome is therefore ... A case report of a patient with idiopathic lower extremity deep vein thrombosis in association with human immunodeficiency ... Deep vein thrombosis as a manifestation of the acquired immunodeficiency syndrome? A case report Cent Afr J Med. 1996 Nov;42(11 ... The possibility of deep vein thrombosis being a manifestation of the acquired immunodeficiency syndrome is therefore ...

https://pubmed.ncbi.nlm.nih.gov/9130416/?dopt=Abstract

The Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (Prevention and Control) Act, 2017, often shortened to ... "The Human Immunodeficiency Virus And Acquired Immune Deficiency Syndrome (Prevention And Control) Bill, 2014". www.prsindia.org ...

https://en.wikipedia.org/wiki/Human_Immunodeficiency_Virus_and_Acquired_Immune_Deficiency_Syndrome_(Prevention_and_Control)_Act,_2017

Keywords : Acquired immunodeficiency syndrome; Human immunodeficiency virus; Meningoencephalitis; Myocarditis; Trypanosomiasis ...

http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651993000200014&lng=en&nrm=iso&tlng=pt

Who must have human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS) and bloodborne pathogen training?. ...

http://apps.leg.wa.gov/wac/default.aspx?cite=170-295-1110

Because the increased TB morbidity in NYC was concurrent with the acquired immunodeficiency syndrome (AIDS) epidemic and was concentrated in the group with 80% of all NYC AIDS patients (males 20-49 years of age), a special study was conducted to evaluate the hypothesis that increased TB morbidity might be related to AIDS. (cdc.gov)
AIDS is an advanced stage of infection with the human immunodeficiency virus ( HIV ). (medicinenet.com)
AIDS is an acronym for acquired immunodeficiency syndrome. (medicinenet.com)
The human immunodeficiency virus (HIV) causes AIDS and represents the most advanced stage of HIV infection. (medicinenet.com)
During 1994, state, local, and territorial health departments reported to CDC 80,691 cases of acquired immunodeficiency syndrome (AIDS) among persons in the United States, which followed the 106,618 cases reported in 1993. (cdc.gov)
Acquired immunodeficiency syndrome (AIDS) is the most advanced stage of HIV infection. (nih.gov)
Concern about a possible association between human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)* infection and increased tuberculosis morbidity (1,2) led to an evaluation of data on acquired immunodeficiency syndrome (AIDS) and tuberculosis. (cdc.gov)
During 1992, state and territorial health departments reported 47,095 cases of acquired immunodeficiency syndrome (AIDS) to CDC, an increase of 3.5% over the 45,499 cases reported in 1991. (cdc.gov)
however, the annual number of women aged 20-29 years with heterosexually acquired AIDS increased by 96.7% since 1988. (cdc.gov)
In addition, the greatest increase among women aged 20-29 years with heterosexually acquired AIDS was in the South (165.5% since 1988). (cdc.gov)
Three cases of Sjögren's syndrome-like illness occurring in patients with the acquired immunodeficiency syndrome (AIDS)-related complex (ARC) are described. (nih.gov)
The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immunodeficiency syndrome (AIDS). (nih.gov)
Human Immunodeficiency Virus (HIV) / Acquired Immunodeficiency Syndrome (AIDS) is medically treatable and is not transmitted by casual contact, and employees with HIV may live full and active lives. (caut.ca)
What are signs that human immunodeficiency virus (HIV) is turning into acquired immune deficiency syndrome (AIDS)? (webmd.com)
What infections and illnesses are related to acquired immune deficiency syndrome (AIDS)? (webmd.com)
This study will identify genetic factors associated with the development of progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS). (clinicaltrials.gov)
The association of Reiter's Syndrome (RS) with the Acquired Immunodeficiency Syndrome (AIDS) is seldom mentioned in the medical literature. (scielo.br)
Acquired Immunodeficiency Syndrome (AIDS) is a disease that affects the immune system. (justanswer.com)
What are personality changes as Acquired Immunodeficiency Syndrome (AIDS) progresses? (justanswer.com)
We have examined 11 patients with the acquired immunodeficiency syndrome (AIDS) for evidence of subclinical vitamin B12 malabsorption. (nih.gov)
In addition, 15% of an unselected population of 121 patients with AIDS and 7% of 27 patients without AIDS who were seropositive for human immunodeficiency virus type 1 (HIV-1) had low serum vitamin B12 levels. (nih.gov)
Background and Purpose- Although acquired immunodeficiency syndrome (AIDS) is thought to increase the risk of stroke, few data exist to quantify this risk. (ahajournals.org)
Stroke has often been reported as a complication of acquired immunodeficiency syndrome (AIDS). (ahajournals.org)
WAC 170-295-1110: Who must have human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS) and bloodborne pathogen training? (wa.gov)
Acquired immunodeficiency syndrome (AIDS) is a chronic, sexually transmitted infection, caused by the human immunodeficiency virus (HIV). (scirp.org)
Human immunodeficiency virus type 1 (HIV-1) infection of CD4 + T cells in the gut plays an insidious role in acquired immunodeficiency syndrome (AIDS) pathogenesis. (frontiersin.org)
AIDS or acquired immunodeficiency syndrome is a disease that affects the immune system of a human being and is caused by the HIV or human immunodeficiency virus. (medicalhealthtests.com)
Lymphocyte status of lymph node and blood in acquired immunodeficiency syndrome (AIDS) and AIDS-related complex disease. (thefreedictionary.com)
The Vanderbilt University School of Medicine Acquired Immunodeficiency Syndrome (AIDS) Education Outreach Program was developed in 1996 to help increase knowledge of AIDS/Human Immunodeficiency Virus (HIV) and to provide adolescents with the tools to make informed decisions about behaviors which put them at risk for HIV infection. (thefreedictionary.com)
Approved on August 26, 1998 for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) who are intolerant of or have a contraindication to other treatment(s) for CMV retinitis or who were insufficiently responsive to previous treatment(s) for CMV retinitis. (thefreedictionary.com)
Acquired immunodeficiency syndrome (AIDS): Implications for counseling and education. (thefreedictionary.com)
One of the items available is a multipage fact sheet designed specifically for persons who have human immunodeficiency virus infection (HIV) or acquired immunodeficiency syndrome (AIDS). (thefreedictionary.com)
In 1988 the Africa Region of the World Bank adopted an agenda for action on the Acquired Immunodeficiency Syndrome (AIDS) epidemic in Africa. (thefreedictionary.com)
AIDS is a disease due to infection with the human immunodeficiency virus (HIV). (lymphedemapeople.com)
The family physician's roles include providing patient education to prevent uninfected persons from becoming infected, identifying and counseling infected persons, delivering comprehensive medical care (including antiretroviral treatment), prophylaxis against opportunistic infections, management of the acquired immunodeficiency syndrome (AIDS), and providing support and care for the family. (springer.com)
BACKGROUND AND METHODS: Symptomatic pulmonary aspergillosis has rarely been reported in patients with the acquired immunodeficiency syndrome (AIDS). (aspergillus.org.uk)
We describe the predisposing factors, the clinical and radiologic features, and the therapeutic outcomes in 13 patients with pulmonary aspergillosis, all of whom had human immunodeficiency virus (HIV) infection and 12 of whom had AIDS. (aspergillus.org.uk)
Purified helper-inducer (T4+) and suppressor-cytotoxic (T8+) lymphocytes from eight patients with acquired immunodeficiency syndrome (AIDS) and eight healthy heterosexual donors were examined by limiting dilution analysis for their ability to be clonally expanded. (jci.org)
Bacterial and fungal infections are common in acquired immunodeficiency syndrome (AIDS). (ajtmh.org)
The Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (Prevention and Control) Act, 2017, often shortened to the HIV/AIDS Prevention Act, is an act of the Parliament of India that provides for controlling and preventing of HIV/AIDS and securing the rights of individuals diagnosed with HIV/AIDS. (wikipedia.org)
Acquired immunodeficiency syndrome (AIDS)-related primary central nervous system lymphoma (AR-PCNSL) is an Epstein-Barr (EBV)-associated malignancy that occurs in severely immunocompromised human immunodeficiency virus (HIV)-infected patients. (haematologica.org)
The disease called acquired immunodeficiency syndrome, but better known as AIDS, is a complicated illness that may involve several phases. (britannica.com)
The patient with acquired immunodeficiency syndrome (AIDS) often present the signs and symptoms of impaired left (LV) and right ventricle (RV) function.The aim of this study was to determine RVmorphology and function during AIDS and analyze of relation with the time of infection and initiation of retroviral therapy. (ovid.com)
Measures of acquired immunodeficiency syndrome (AIDS)-related knowledge that have good psychometric properties are needed to evaluate the impact of educational interventions, particularly among impoverished populations. (homelesshub.ca)
Acquired Immunodeficiency Syndrome (AIDS) is caused by the human immunodeficiency virus (HIV), which destroys the cells in the human body that combat infections. (jrank.org)
In the 25 years since the first reported cases of acquired immunodeficiency syndrome (AIDS), more than 70 million people have been infected with the human immunodeficiency virus (HIV). (oxfordmedicine.com)
In murine acquired immunodeficiency syndrome (AIDS), TH1 deficiency enables the host to be susceptible to coxsackievirus infection, inducing cardiopathology in a short period. (openthesis.org)
Human immunodeficiency virus (HIV) is a lent virus (slowly-replicating retrovirus) that causes acquired immunodeficiency syndrome (AIDs). (pharmatutor.org)
Immune reconstitution inflammatory syndrome during anti-retroviral treatment of acquired immunodeficiency syndrome (AIDS) -associated gastrointestinal Kaposi's sarcoma has rarely been reported. (springermedizin.de)
Our patient was diagnosed to be having immune reconstitution inflammatory syndrome associated with AIDS-associated gastrointestinal limited Kaposi's sarcoma, which presented as acute intestinal obstruction. (springermedizin.de)
Immune reconstitution inflammatory syndrome involving Kaposi's sarcoma may occur in HAART-naïve individuals with AIDS-related Kaposi's sarcoma. (springermedizin.de)
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). (drugster.info)
In a series of 157 patients with acquired immunodeficiency syndrome (AIDS), 46 (29%) developed cytomegalovirus (CMV) retinitis. (elsevier.com)
Although the incidence of some STD s has reached epidemic proportions, it was not until the advent of the acquired immunodeficiency syndrome ( AIDS ) that the need to restrain the transmission of these diseases gained serious attention. (britannica.com)
AIDS is caused by the human immunodeficiency virus ( HIV ), a pernicious infectious agent that attacks the immune system , leading to its progressive destruction. (britannica.com)
The GLBs identified a need for human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) education and had concerns about their general health, discrimination against them and vulnerability to violence including sexual assaults. (academicconcepts.net)
In this study, we outline the implementation of a human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) prevention program in an educational setting in South Africa. (academicconcepts.net)
A 33‐year‐old black woman with advanced acquired immunodeficiency syndrome (AIDS) presented with rapidly progressive muscle weakness and serologic and radiologic evidence of central nervous system Toxoplasma infection. (uab.edu)
AIDS is caused by human immunodeficiency virus (HIV). (thedispatch.in)
A transplant patient was infected with Acquired Immunodeficiency Syndrome or AIDS after he had received a new kidney from a living donor. (yourdailynewsfix.com)

Characterization of the gag/fusion protein encoded by the defective Duplan retrovirus inducing murine acquired immunodeficiency syndrome. (asm.org)
Murine acquired immunodeficiency syndrome is induced by a defective retrovirus. (asm.org)
Our data indicate that Pr60gag is a major (and possibly the only) gene product of the defective murine acquired immunodeficiency syndrome virus and is likely to harbor some determinants of pathogenicity of this virus. (asm.org)
T-cell Receptor Vbeta8.1 Peptide Reduces Coxsackievirus-induced Cardiopathology During Murine Acquired Immunodeficiency Syndrome and Aging. (openthesis.org)

USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: a summary. (springer.com)
Combined highly active anti-retroviral therapy (HAART) with protease and reverse transcriptase inhibitors has modified the natural history of opportunistic infections and neoplasms in human immunodeficiency virus (HIV)-infected patients. (semanticscholar.org)
There is increasing immunodeficiency, and opportunistic infections become more frequent, severe, and difficult to treat. (brainkart.com)

Palatal perforation with granulomatous pansinusitis caused by deep mycotic infection is a rare complication of acquired immunodeficiency syndrome. (quintpub.com)

OBJECTIVE To define the contributions of human immunodeficiency virus (HIV) and hepatitis C virus infections to the development of porphyria cutanea tarda. (semanticscholar.org)

The occurrence of Sjögren's syndrome in ARC provides further evidence for autoimmune phenomena arising in the severely damaged immune system of ARC patients. (nih.gov)
The histologic findings suggest that a specific pathologic process occurs in the lamina propria of the small intestine and colon in some patients with the syndrome. (annals.org)
Patients infected by the human immunodeficiency virus are predisposed to many infectious and noninfectious complications and often receive a variety of drugs. (bmj.com)
It is therefore surprising that only a few cases of the neuroleptic malignant syndrome have been described in patients with the acquired immunodeficiency syndrome. (bmj.com)
A high index of suspicion is required to diagnose the neuroleptic malignant syndrome in these patients, as its usual manifestations, including fever and altered consciousness, are frequently attributed to an underlying infection. (bmj.com)
Patients with acquired immunodeficiency syndrome frequently develop complications of cardiac, pericardial, and thoracic vascular origin. (ovid.com)
Patients with acquired immunodeficiency syndrome often demonstrate enlargement of the cardiac silhouette on the chest radiograph. (ovid.com)
Care for patients with human immunodeficiency virus (HIV) infection requires excellence in all aspects of family practice. (springer.com)
Glatt AE, Anand A. Thrombocytopenia in patients infected with human immunodeficiency virus: treatment update. (springer.com)
Histoplasmosis is a common fungal disease in severely immunocompromised patients infected with human immunodeficiency virus (HIV) in endemic areas. (ajtmh.org)
Geographic distribution, frequency, and specimen source of Mycobacterium avium complex serotypes isolated from patients with acquired immunodeficiency syndrome. (asm.org)
P353Is possible to determine early stage of right ventricle dysfunction in the patients with acquired immunodeficiency syndrome? (ovid.com)
2. Tissue Doppler Imaging (TDI) is simple and sensitive tool to assess impaired RV function in patients with acquired immunodeficiency syndrome. (ovid.com)
Zurück zum Zitat Friedman S, Wright T, Altman S: Gastrointestinal Kaposi's sarcoma in patients with acquired immunodeficiency syndrome: endoscopic and autopsy finding. (springermedizin.de)
Influence of highly active anti-retroviral therapy on response to treatment and survival in patients with acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma treated with cyclophosphamide, hydroxydoxorubicin, vincristine and prednisone. (semanticscholar.org)
Comparison of two initial mobilizing strategies of peripheral blood stem cells for autologous transplantation in patients with lymphoma and human immunodeficiency virus infection]. (semanticscholar.org)
Abnormal serum porphyrin levels in patients with the acquired immunodeficiency syndrome with or without hepatitis C virus infection. (semanticscholar.org)
In resource-poor settings, 25% of patients receiving HAART may develop CNS-related immune reconstitution inflammatory syndrome (IRIS). (biomedcentral.com)

Gastrointestinal histoplasmosis in the acquired immunodeficiency syndrome: report of 18 cases and literature review. (ajtmh.org)

In recent years, reported tuberculosis (TB) cases in New York City (NYC) have increased substantially, in large part related to coexisting human immunodeficiency virus (HIV) and Mycobacterium tuberculosis infection. (cdc.gov)
Tuberculosis and human immunodeficiency virus infection: recommendations of the Advisory Committee for the Elimination of Tuberculosis (ACET). (springer.com)

What are symptoms of human immunodeficiency virus (HIV)? (webmd.com)
What is the HIV and Acquired Immunodeficiency Syndrome symptoms? (justanswer.com)
And when you label a condition incorrectly it can also place pressure on the acquired immunodeficiency syndrome a chromosome 21 from the acquired immunodeficiency syndrome are also at risk of giving birth to a random event during the acquired immunodeficiency syndrome but sometimes an extra copy is also something that teenagers with Down Syndrome can develop for many years with no noticeable symptoms. (blogspot.com)

Consensus statement on the use of corticosteroids as adjunctive therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: the National Institutes of Health-University of California Expert Panel for Corticosteroids as Adjunctive Therapy for Pneumocystis carinii pneumonia. (springer.com)

1989)‎. SEA/RC42/R2 - Acquired Immunodeficiency Syndrome. (who.int)

Acquired defect of cellular immunity that occurs in cats infected with feline immunodeficiency virus (FIV) and in some cats infected with feline leukemia virus (FeLV). (ctdbase.org)

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. (asm.org)
We constructed an infectious molecular clone of acquired immunodeficiency syndrome-associated retrovirus. (asm.org)

Lifson, AR 1992, ' Current issues concerning the epidemiology of acquired immunodeficiency syndrome and human immunodeficiency virus ', Western Journal of Medicine , vol. 156, no. 1, pp. 52-56. (umn.edu)

Revision of the CDC Surveillance Case Definition for Acquired Immunodeficiency Syndrome ," Morbidity and Mortality Weekly Report, 1987: 36(supplement no. (thefreedictionary.com)

Triangle Pharmaceuticals is a specialty pharmaceutical company engaged in the development of new antiviral drug candidates, with a particular focus on therapies for the human immunodeficiency virus, including the acquired immunodeficiency syndrome , and hepatitis B virus. (thefreedictionary.com)

To the editor: We recently treated a patient with the acquired immunodeficiency syndrome and disseminated infection due to Mycobacterium gordonae . (annals.org)
Horsburgh CR Jr. Mycobacterium avium complex infection in the acquired immunodeficiency syndrome. (springer.com)

The Division of Acquired Immunodeficiency Syndrome (DAIDS) is a division of the National Institute of Allergy and Infectious Diseases which is part of the National Institutes of Health. (wikipedia.org)
Aberg JA, Gallant JE, Anderson J, et al: Primary care guidelines for the management of persons infected with human immunodeficiency virus: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. (freemd.com)
Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV medicine Association of the Infectious Diseases Society of America. (freemd.com)

To explore the effect of the acquired immunodeficiency syndrome on gastrointestinal structure and absorption, the cases of 12 homosexual men with the syndrome and 11 homosexual controls were studied. (annals.org)

Public Health Service statement on management of occupational exposure to human immunodeficiency virus, including considerations regarding zidovudine postexposure use. (springer.com)
A 30-yr-old man with acquired immunodeficiency syndrome treated with zidovudine developed biopsy-proven mitochondrial myopathy. (asnjournals.org)

Impact of Human Immunodeficiency Virus Type 1 Subtype on HIV. (lww.com)

Acquired immunodeficiency syndrome and lupus erythematosus are multisystem diseases that can affect several organs and systems at different stages of disease evolution. (scirp.org)
To cure the acquired immunodeficiency syndrome of cortiol due to diseases of circulatory system particularly due to parental behavior or environmental factors. (blogspot.com)

HIV infection/acquired immunodeficiency syndrome and SLE share several clinical manifestations in common. (scirp.org)
This once unusual lesion of the salivary gland has been recently associated with infection by the human immunodeficiency virus (HIV) and is presently encountered with increased frequency in the clinical practice. (biomedsearch.com)
Clinical presentation and outcome of acquired immunodeficiency syndrome-related histoplasmosis are unknown in non-endemic areas with wide access to highly active anti-retroviral therapy (HAART). (ajtmh.org)
Clinical features and outcome of all adults with proven acquired immunodeficiency syndrome-related histoplasmosis were compared between the two periods. (ajtmh.org)
Diarrhea is a common clinical manifestation of human immunodeficiency virus ( HIV ) infection . (bvsalud.org)

Increased susceptibility to brain infection was due to severe immunodeficiency at 8 wks p.i. and a marked increase in programmed death-1 (PD-1) expression on CD4 + and CD8 + T-cells. (biomedcentral.com)

Central nervous system immune reconstitution inflammatory syndrome (CNS-IRIS) is characterized by neurological deterioration despite immune recovery from an immunodeficient state. (haematologica.org)

Reiter's Syndrome (RS) fits into the spectrum of specific organic pathology of the reactive arthritis group [1], with the addition of extra articular manifestations. (scielo.br)

Acquired mutation: A genetic change that occurs in a single cell after the conception of an individual. (definithing.com)

As in previous years, most (50.8%) cases were attributable to transmission of human immunodeficiency virus (HIV) among homosexual/bisexual men ( Table 1 ). (cdc.gov)
In 2007, about half of new HIV cases were acquired by men having sex with other men. (thefreedictionary.com)

Deep vein thrombosis as a manifestation of the acquired immunodeficiency syndrome? (nih.gov)
The possibility of deep vein thrombosis being a manifestation of the acquired immunodeficiency syndrome is therefore highlighted. (nih.gov)

Rates of DNTM were lower in Hispanics and declined with age but were not significantly different by patient sex or means of acquiring HIV infection. (nih.gov)
Systemic mycosis due to Penicillium marneffei in a patient with antibody to human immunodeficiency virus. (springer.com)
Disseminated penicilliosis in a patient with acquired immunodeficiency syndrome. (springer.com)
Systemic infection caused by Penicillium decumbens in a patient with acquired immunodeficiency syndrome. (springer.com)
A case report of a patient with idiopathic lower extremity deep vein thrombosis in association with human immunodeficiency virus infection is presented. (nih.gov)
Chronic lactic acidosis in a patient with acquired immunodeficiency syndrome and mitochondrial myopathy: biochemical studies. (asnjournals.org)

Is the suicide rate among people with Acquired Immunodeficiency Syndrome high? (justanswer.com)
Infection of people with human immunodeficiency virus (HIV) as well as LP- BM5 infection in mice results in progressive deterioration of the immune system in the majority of untreated hosts. (openthesis.org)
Marriage is by no means common for people with Down Syndrome has always been with us, but it was not until the acquired immunodeficiency syndrome that anyone thought to research and will look to integrate my findings into my current Energy Psychology sessions and the acquired immunodeficiency syndrome a baby with Down syndrome, but it is caused due to primary adrenal tumor. (blogspot.com)

Editorial Note: The data from this study, as well as other evidence presented below, suggest that human immunodeficiency virus (HIV) infection is causing a resurgence of TB in NYC. (cdc.gov)

Anatomy16

Organisms24

Diseases76

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Psychiatry and Psychology9

Phenomena and Processes35

Anthropology, Education, Sociology and Social Phenomena2

Information Science6

Named Groups3

Health Care19

Geographicals7

Dysregulated production of interleukin-8 in individuals infected with human immunodeficiency virus type 1 and Mycobacterium tuberculosis. (1/6107)

Incidence and duration of hospitalizations among persons with AIDS: an event history approach. (2/6107)

Relative rates of AIDS among racial/ethnic groups by exposure categories. (3/6107)

Outcome and predictors of failure of highly active antiretroviral therapy: one-year follow-up of a cohort of human immunodeficiency virus type 1-infected persons. (4/6107)

Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. (5/6107)

Proliferative responses to human immunodeficiency virus type 1 (HIV-1) gp120 peptides in HIV-1-infected individuals immunized with HIV-1 rgp120 or rgp160 compared with nonimmunized and uninfected controls. (6/6107)

No evidence for an effect of the CCR5 delta32/+ and CCR2b 64I/+ mutations on human immunodeficiency virus (HIV)-1 disease progression among HIV-1-infected injecting drug users. (7/6107)

A randomized trial of high- versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection. (8/6107)

Acquired Immunodeficiency Syndrome

Murine Acquired Immunodeficiency Syndrome

Syndrome

HIV-1

HIV Infections

Simian immunodeficiency virus

HIV

AIDS-Related Opportunistic Infections

Simian Acquired Immunodeficiency Syndrome

AIDS-Related Complex

Immunologic Deficiency Syndromes

Feline Acquired Immunodeficiency Syndrome

Immunodeficiency Virus, Feline

Homosexuality

Severe Combined Immunodeficiency

HIV Seropositivity

Zidovudine

Anti-HIV Agents

Common Variable Immunodeficiency

CD4 Lymphocyte Count

Pneumonia, Pneumocystis

HIV Antibodies

Virus Replication

Lymphoma, AIDS-Related

Molecular Sequence Data

tat Gene Products, Human Immunodeficiency Virus

HIV Antigens

Antiretroviral Therapy, Highly Active

HIV-2

Deltaretrovirus

HIV Envelope Protein gp120

Sarcoma, Kaposi

Macaca mulatta

HIV Core Protein p24

Gene Products, gag

RNA, Viral

Viral Load

Cytomegalovirus Retinitis

Opportunistic Infections

Down Syndrome

Antigens, CD4

Metabolic Syndrome X

CD4-Positive T-Lymphocytes

DNA, Viral

Reverse Transcriptase Inhibitors

Base Sequence

Cell Line

Retroviridae Infections

T-Lymphocytes

Toxoplasmosis, Cerebral

Amino Acid Sequence

HIV Reverse Transcriptase

Mutation

Gene Products, env

nef Gene Products, Human Immunodeficiency Virus

Retroviridae Proteins

Lymphatic Diseases

HIV Seronegativity

AIDS Serodiagnosis

Didanosine

Antiviral Agents

gag Gene Products, Human Immunodeficiency Virus

Polymerase Chain Reaction

Substance Abuse, Intravenous

AIDS Dementia Complex

HIV Seroprevalence

Receptors, CCR5

Fatal Outcome

HIV Protease Inhibitors

RNA-Directed DNA Polymerase

Antibodies, Viral

AIDS Vaccines

HIV Long Terminal Repeat

Pentamidine

rev Gene Products, Human Immunodeficiency Virus

United States

Gene Products, tat

Risk Factors

Hemophilia A

Immunocompromised Host