A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has antiinflammatory and antineuralgic properties.
A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.
A benzoate-cevane found in VERATRUM and Schoenocaulon. It activates SODIUM CHANNELS to stay open longer than normal.
A class of drugs that stimulate sodium influx through cell membrane channels.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Batrachotoxin is the 20-alpha-bromobenzoate of batrachotoxin A; they are toxins from the venom of a small Colombian frog, Phyllobates aurotaenia, cause release of acetylcholine, destruction of synaptic vesicles and depolarization of nerve and muscle fibers.
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
A nucleus of the middle hypothalamus, the largest cell group of the tuberal region with small-to-medium size cells.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.
An interactive process whereby members of a community are concerned for the equality and rights of all.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A cell line derived from cultured tumor cells.
Established cell cultures that have the potential to propagate indefinitely.
An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
Drugs used to prevent SEIZURES or reduce their severity.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic (i.e., occurring secondary to known disease processes such as infections, hypoxic-ischemic injuries, trauma, etc.).
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Substances that reduce the growth or reproduction of BACTERIA.
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
RNA that has catalytic activity. The catalytic RNA sequence folds to form a complex surface that can function as an enzyme in reactions with itself and other molecules. It may function even in the absence of protein. There are numerous examples of RNA species that are acted upon by catalytic RNA, however the scope of this enzyme class is not limited to a particular type of substrate.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices. (1/219)

1. Whole-cell clamp recordings of the compound synaptic current elicited by afferent stimulation of Schaffer collaterals showed that blockade of the NMDA, AMPA and GABAA receptor-mediated components by 6-nitro-7-sulphamoyl- benzo(f)quinoxaline-2,3-dione (NBQX), 3-((R)-2-carboxypiperazine-4-yl)propyl-1-phosphonate (R-CPP) and picrotoxin, respectively, left a small residual current in 39 out of 41 CA1 pyramidal neurones in organotypic cultures and 9 out of 16 CA1 cells in acutely prepared slices. 2. This current represented 2. 9 +/- 0.4 % of the compound evoked synaptic response in organoypic cultures and 1.4 +/- 0.5 % in slices. It was characterized by a slightly rectifying I-V curve and a reversal potential of 3.4 +/- 5. 1 mV. 3. This residual current was insensitive to blockers of GABAB, purinergic, muscarinic and 5-HT3 receptors, but it was essentially blocked by the nicotinic receptor antagonist d-tubocurarine (91 +/- 4 % blockade; 20 microM), and partly blocked by alpha-bungarotoxin (200 nM) and methyllycaconitine (10 nM), two antagonists with a higher selectivity for alpha7 subunit-containing nicotinic receptors (48 +/- 3 % and 55 +/- 11 % blockade, respectively). 4. The residual current was of synaptic origin, since it occurred after a small delay; its amplitude depended upon the stimulation intensity and it was calcium dependent and blocked by the sodium channel antagonist tetrodotoxin. 5. We conclude that afferent stimulation applied in the stratum radiatum evokes in some hippocampal neurones a small synaptic current mediated by activation of neuronal nicotinic receptors.  (+info)

Nicotinic acetylcholine receptors assembled from the alpha7 and beta3 subunits. (2/219)

Intracellular recordings were performed in voltage-clamped Xenopus oocytes upon injection with a mixture of cDNAs encoding the beta3 and mutant alpha7 (L247Talpha7) neuronal nicotinic acetylcholine receptor (nAChR) subunits. The expressed receptors maintained sensitivity to methyllycaconitine and to alpha-bungarotoxin but exhibited a functional profile strikingly different from that of the homomeric L247Talpha7 receptor. The heteromeric L247Talpha7beta3 nAChR had a lower apparent affinity and a faster rate of desensitization than L247Talpha7 nAChR, exhibited nonlinearity in the I-V relationship, and was inhibited by 5-hydroxytryptamine, much like wild type alpha7 (WTalpha7) nAChR. Single channel recordings in cell-attached mode revealed unitary events with a slope conductance of 19 picosiemens and a lifetime of 5 ms, both values being much smaller than those of the homomeric receptor channel. Upon injection with a mixture of WTalpha7 and beta3 cDNAs, clear evidence was obtained for the plasma membrane assembly of heteromeric nAChRs, although ACh could not activate these receptors. It is concluded that beta3, long believed to be an orphan subunit, readily co-assembles with other subunits to form heteromeric receptors, some of which may be negative regulators of cholinergic function.  (+info)

Effects of Delphinium alkaloids on neuromuscular transmission. (3/219)

The Delphinium alkaloids methyllycaconitine (MLA), nudicauline, 14-deacetylnudicauline (14-DN), barbinine, and deltaline were investigated for their effects on neuromuscular transmission in lizards. The substituent at C14 provides the only structural difference among the alkaloids MLA, nudicauline, 14-DN, and barbinine. Deltaline lacks the N-(methylsuccinyl)anthranilic acid at C18 common to the other four alkaloids. Each alkaloid reversibly reduced extracellularly recorded compound muscle action potential (CMAP) amplitudes in a concentration-dependent manner. The IC(50) values for CMAP blockade were between 0.32 and 13.2 microM for the N-(methylsuccinimido)anthranoyllycacotonine-type alkaloids and varied with the C14 moiety; the IC(50) value for deltaline was 156 microM. The slopes of the concentration-response curves for CMAP blockade were similar for each alkaloid except barbinine, whose shallower curve suggested alternative or additional mechanisms of action. Each alkaloid reversibly reduced intracellularly recorded spontaneous, miniature end-plate potential (MEPP) amplitudes. Alkaloid concentrations producing similar reductions in MEPP amplitude were 0.05 microM for 14-DN, 0.10 microM for MLA, 0.50 microM for barbinine, and 20 microM for deltaline. Only barbinine altered the time constant for MEPP decay, further suggesting additional or alternative effects for this alkaloid. MLA and 14-DN blocked muscle contractions induced by exogenously added acetylcholine. All five alkaloids are likely nicotinic receptor antagonists that reduce synaptic efficacy and block neuromuscular transmission. The substituent at C14 determines the potency and possibly the mechanism of nicotinic acetylcholine receptor blockade for MLA, nudicauline, 14-DN, and barbinine at neuromuscular synapses. The lower potency of deltaline indicates that the N-(methylsuccinyl)anthranilic acid at C18 affects alkaloid interactions with nicotinic acetylcholine receptors at neuromuscular junctions.  (+info)

Cooperative activation of action potential Na+ ionophore by neurotoxins. (4/219)

Four neurotoxins that activate the action potential Na+ ionophore of electrically excitable neuroblastoma cells interact with two distinct classes of sites, one specific for the alkaloids veratridine, batrachotoxin, and aconitine, and the second specific for scorpion toxin. Positive heterotropic cooperativity is observed between toxins bound at these two classes of sites. Tetrodotoxin is a noncompetitive inhibitor of activation by each of these toxins (KI = 4-8 nM). These results suggest the existence of three functionally separable components of the action potential Na+ ionophore: two regulatroy components, which bind activating neurotoxins and interact allosterically in controlling the activity of a third ion-transport component, which binds tetrodotoxin.  (+info)

Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks. (5/219)

Cholinergic control of the activity of human cerebral cortical circuits has long been thought to be accounted for by the interaction of acetylcholine (ACh) with muscarinic receptors. Here we report the discovery of functional nicotinic receptors (nAChRs) in interneurons of the human cerebral cortex and discuss the physiological and clinical implications of these findings. The whole-cell mode of the patch-clamp technique was used to record responses triggered by U-tube application of the nonselective agonist ACh and of the alpha7-nAChR-selective agonist choline to interneurons visualized by means of infrared-assisted videomicroscopy in slices of the human cerebral cortex. Choline induced rapidly desensitizing whole-cell currents that, being sensitive to blockade by methyllycaconitine (MLA; 50 nM), were most likely subserved by an alpha7-like nAChR. In contrast, ACh evoked slowly decaying whole-cell currents that, being sensitive to blockade by dihydro-beta-erythroidine (DHbetaE; 10 microM), were most likely subserved by an alpha4beta2-like nAChR. Application of ACh (but not choline) to the slices also triggered GABAergic postsynaptic currents (PSCs). Evidence is provided that ACh-evoked PSCs are the result of activation of alpha4beta2-like nAChRs present in preterminal axon segments and/or in presynaptic terminals of interneurons. Thus, nAChRs can relay inhibitory and/or disinhibitory signals to pyramidal neurons and thereby modulate the activity of neuronal circuits in the human cerebral cortex. These mechanisms, which appear to be retained across species, can account for the involvement of nAChRs in cognitive functions and in certain neuropathological conditions.  (+info)

Anti-arrhythmic effects of sophoridine and oxysophoridine. (6/219)

AIM: To compare the effects of oxysophoridine (Oxy) and sophoridine (Sop) on experimental arrhythmias and myocardial physiologic properties. METHODS: Arrhythmias were induced by drugs and myocardial ischemia. Physiologic properties were determined on isolated heart atria. RESULTS: Oxy 500 mg.kg-1 (1/6 LD50) decreased the incidence of ventricular arrhythmias induced by aconitine (P < 0.01), increased the threshold dose of ouabain-induced ventricular premature (VP, P < 0.05), ventricular tachycardia (VT, P < 0.05), ventricular fibrillation (VF, P < 0.01), and cardiac arrest, (P < 0.01). After i.v. Oxy 500 mg.kg-1 into the rats with ligation of left anterior descending coronary artery, the total numbers of ectopic beats were decreased (P < 0.05), the incidence of VF was lowered, and the duration of VT was shortened (P < 0.01). Oxy 250 mg.kg-1 (1/13 LD50) i.v. shortened the duration of arrhythmias induced by BaCl2 (P < 0.01) and delayed the onset of arrhythmias induced by chloroform-epinephrine (P < 0.05). Oxy produced dose-dependent positive inotropic effects in the isolated left atrial of guinea pigs, increased the concentration of epinephrine to elicit automaticity in left atria, decreased slightly the excitability, and prolonged the functional refractory period. Sop produced the similar effects on arrhythmias as Oxy. CONCLUSION: Oxy produced the similar anti-arrhythmic effects as Sop did at the equivalent effective dose.  (+info)

Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons. (7/219)

Nicotinic acetylcholine receptors (nAChRs) are expressed in the hippocampus, and their functional roles are beginning to be delineated. The effect of nAChR activation on the activity of both interneurons and pyramidal neurons in the CA1 region was studied in rat hippocampal slices. In CA1 stratum radiatum with muscarinic receptors inhibited, local pressure application of acetylcholine (ACh) elicited a nicotinic current in 82% of the neurons. The majority of the ACh-induced currents were sensitive to methyllycaconitine, which is a specific inhibitor of alpha7-containing nAChRs. Methyllycaconitine-insensitive nicotinic currents also were present as detected by a nonspecific nAChR inhibitor. The ACh-sensitive neurons in the s. radiatum were identified as GABAergic interneurons by their electrophysiological properties. Pressure application of ACh induced firing of action potentials in approximately 70% of the interneurons. The ACh-induced excitation of interneurons could induce either inhibition or disinhibition of pyramidal neurons. The inhibition was recorded from the pyramidal neuron as a burst of GABAergic synaptic activity. That synaptic activity was sensitive to bicuculline, indicating that GABA(A) receptors mediated the ACh-induced synaptic currents. The disinhibition was recorded from the pyramidal neuron as a reduction of spontaneous GABAergic synaptic activity when ACh was delivered onto an interneuron. Both the inhibition and disinhibition were sensitive to either methyllycaconitine or mecamylamine, indicating that activation of nicotinic receptors on interneurons was necessary for the effects. These results show that nAChRs are capable of regulating hippocampal circuits by exciting interneurons and, subsequently, inhibiting or disinhibiting pyramidal neurons.  (+info)

Two distinct classes of functional 7-containing nicotinic receptor on rat superior cervical ganglion neurons. (8/219)

Nicotinic acetylcholine receptors (nAChRs) that bind alpha-bungarotoxin (alpha Bgt) were studied on isolated rat superior cervical ganglion (SCG) neurons using whole-cell patch clamp recording techniques. Rapid application of ACh onto the soma of voltage clamped neurons evoked a slowly desensitizing current that was reversibly blocked by alpha Bgt (50 nM). The toxin-sensitive current constituted on average about half of the peak whole-cell response evoked by ACh. Nanomolar concentrations of methyllycaconitine blocked the alpha Bgt-sensitive component of the ACh-evoked current as did intracellular dialysis with an anti-alpha 7 monoclonal antibody. The results indicate that the slowly reversible toxin-sensitive response elicited by ACh arises from activation of an unusual class of alpha 7-containing receptor (alpha 7-nAChR) similar to that reported previously for rat intracardiac ganglion neurons. A second class of functional alpha 7-nAChR was identified on some SCG neurons by using rapid application of choline to elicit responses. In these cases a biphasic response was obtained, which included a rapidly desensitizing component that was blocked by alpha Bgt in a pseudo-irreversible manner. The pharmacology and kinetics of the responses resembled those previously attributed to alpha 7-nAChRs in a number of other neuronal cell types. Experiments measuring the dissociation rate of 125I-labelled alpha Bgt from SCG neurons revealed two classes of toxin-binding site. The times for toxin dissociation were consistent with those required to reverse blockade of the two kinds of alpha Bgt-sensitive response. These results indicate that rat SCG neurons express two types of functional alpha 7-nAChR, differing in pharmacology, desensitization and reversibility of alpha Bgt blockade.  (+info)

The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future.
Bone pain is a common and severe symptom in cancer patients. The present study employed a mouse model of leukemia bone pain by injection K562 cells into tibia of mouse to evaluate the analgesic effects of lappacontine. Our results showed that the lappaconitine treatment at day 15, 17 and 19 could effectively reduce the spontaneous pain scoring values, restore reduced degree in the inclined-plate test induced by injection of K562 cells, as well as restore paw mechanical withdrawal threshold and paw withdrawal thermal latency induced by injection of K562 cells to the normal levels. Additionally, the molecular mechanisms of lappaconitines analgesic effects may be related to affect the expression levels of endogenous opioid system genes (POMC, PENK and MOR), as well as apoptosis-related genes (Xiap, Smac, Bim, NF-κB and p53). Our present results indicated that lappaconitine may become a new analgesic agent for leukemia bone pain management.
TY - JOUR. T1 - Study of alkaloids of the Siberian and Altai flora 13. Synthesis of alkynyllappaconitines. AU - Osadchii, S. A.. AU - Shults, E. E.. AU - Vasilevskii, S. F.. AU - Polukhina, E. V.. AU - Stepanov, A. A.. AU - Tolstikov, G. A.. PY - 2007/2/1. Y1 - 2007/2/1. N2 - The Sonogashira coupling of 5′-iodolappaconitine with prop-2-yn-1-ol, 2-methylbut-3-yn-2-ol, phenylacetylene, and 5-ethynylpyrimidine gave new lappaconitine derivatives containing an alkynyl fragment.. AB - The Sonogashira coupling of 5′-iodolappaconitine with prop-2-yn-1-ol, 2-methylbut-3-yn-2-ol, phenylacetylene, and 5-ethynylpyrimidine gave new lappaconitine derivatives containing an alkynyl fragment.. KW - Alkaloids. KW - Alkynes. KW - Alkynylation. KW - Cross-coupling. KW - Diterpenes. KW - Iodoarenes. KW - Lappaconitine. KW - Sonogashira reaction. UR - http://www.scopus.com/inward/record.url?scp=34547540930&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=34547540930&partnerID=8YFLogxK. U2 - ...
Epidemiological studies demonstrate a significant association between arrhythmias and air pollution exposure. Sensitivity to aconitine-induced arrhythmia has been employed to examine the factors that increase the risk of such dysfunction. We used aconitine to test whether a single exposure to diesel exhaust (DE) would increase the risk of arrhythmia being triggered in hypertensive rats. We hypothesised that DE exposure increases the risk of arrhythmia due to sensory irritation during and after inhalation. Spontaneously hypertensive rats surgically implanted with radiotelemeters were exposed to 150 μg/m3 of DE or filtered air for 4 h. Arrhythmogenesis was assessed 24 h later in urethane-anaesthetised animals by continuous intravenous infusion of aconitine while heart rate (HR) and electrocardiogram (ECG) were monitored. Rats exposed to DE had lower HR when compared to air-exposed animals. Exposure to DE resulted in significantly shorter PR intervals, and significantly prolonged corrected QT ...
Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na+ channels. However, it remains unknown whether it has any effects on K+ currents. The effects of ACO on ion currents in differentiated clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular myocytes were investigated in this study. In H9c2 cells, ACO suppressed ultrarapid-delayed rectifier K+ current (IKur) in a time- and concentration-dependent fashion. The IC50 value for ACO-induced inhibition of IKur was 1.4μM. ACO could accelerate the inactivation of IKur with no change in the activation time constant of this current. Steady-state inactivation curve of IKur during exposure to ACO could be demonstrated. Recovery from block by ACO was fitted by a single-exponential function. The inhibition of IKur by ACO could still be observed in H9c2 cells preincubated with ruthenium red (30μM). Intracellular dialysis with ACO (30μM) had no effects on IKur. IKur elicited by ...
George Henry Lamson (8 September 1852 - 28 April 1882) was an American doctor and murderer. In his early career he had been a volunteer surgeon in Romania and Serbia, and decorated for his work. He returned to England and practised in Bournemouth. He became addicted to morphine and his financial situation grew desperate. In 1881 he visited his 18-year-old brother-in-law Percy John, a hemiplegic, at his boarding school and gave him a slice of Dundee cake. He also gave him a capsule from a batch that were later tested and found to contain the poison aconitine, as recorded in the case history at Old Bailey Online. Lamson was tried in March 1882 with Montagu Williams acting for his defence: he was found guilty of murdering Percy in order to secure a share of the family inheritance. He had poisoned his victim with aconitine in the cake, a substance which Lamson had learnt about from Professor Robert Christison in university. Christison had taught that aconitine was undetectable but forensic science ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Diacetylkorseveriline is an antiarrhythmic (classes i and iv)? belonging to a novel structural class. effective against arrhythmia caused by aconitine? cacl2? electric stimulation of the ventricles or ligature of the aorta, recommended dose for one cycle of experiment on mice: 3.0-30.0 mg/kg? intravenously.
Order MLA Micro D-Tipper Pipette Pipette VistaLab Technologies Manufacturer from a trusted supplier to chemistry & biology labs.
Listing of the answers to the question: What trees will grow under pine trees? I understand that many plants wont survive under pine trees due to the oils in the needles. Which sorts of trees can thrive? Particularly in the Northeast US.
Acetylbenzoylaconin, aconite root, aconiti frus, Aconiti Herba, aconiti lateralis preparata, aconiti tuber, aconitine, aconitknollen, aconito, Aconitum angustius, Aconitum anthoroideum, Aconitumartemisiifolium, Aconitum austroyunnanense, Aconitum balfourii, Aconitum barbatum, Aconitumbrachypodum, Aconitum brunneum, Aconitum carmichaelii, Aconitum chasmanthum, Aconitumchilienshanicum, Aconitum columbianum, Aconitum coreanum, Aconitum episcopale, Aconitumferox, Aconitum flavum, Aconitum gymnandrum, Aconitum hemsleyanum, Aconitum japonicum, Aconitum karakolicum, Aconitum kongboense, Aconitum kusnezoffii, Aconitum longilobum, Aconitum moldavicum, Aconitum nagarum, Aconitum napellus, Aconitum naviculare, Aconitum ouvrardianum, Aconitum paniculigerum, Aconitum pendulum, Aconitum polyschistum, Aconitum pomeense, Aconitum pterocaule, Aconitum racemulosum, Aconitum richardsonianum, Aconitum rotundifolium, Aconitum scaposum, Aconitum sczukinii, Aconitum sessiliflorum, Aconitum sinomantanum Nakai, Aconitum ...
ILO: International Labour Organization - The International Labour Organization is the UN specialized agency which seeks the promotion of social justice and internationally recognized human and labour rights
Aconitum spp is a genus of over 250 flowering plants including Monkshood, Wolfs bane, Aconite, Leopards bane, mousebane, blue rocket, and queen of poisons. In the United States, most poisonous flower ingestions are accidental ingestions by children and account for roughly 2% of all toxic exposures; aconitum is not a commonly ingested flower in the United States, though is responsible for significant morbidity and mortality worldwide. Traditionally, most cases of adult ingestion of toxic flowers that lead to significant symptoms are suicidal attempts. A recent increase in aconitum poisoning has been reported secondary to an increase in available herbal medications utilizing the plant. All parts of Aconitum are toxic, with the roots being most toxic. Toxicity is due to Aconite alkaloids bind to open voltage-gated sodium channels, producing a hyperpolarized state, with permanent activation of the channels. Most herbal preparations undergo decoction process where plant is boiled to hydrolize ...
Background: Thymus vulgaris essential oil (Tv-EO) is known to have antibacterial, antifungal, and antioxidant activities. Encapsulation of Tv-EO in polymeric nanoparticles (NPs) can prevent volatilization of its components and can provide protection against external agents. Under these circumstances, it is crucial to assure the presence and quantity of the Tv-EO components (γ-terpinene, thymol, and carvacrol) in the NPs. Objective: To determine the chemical composition and physicochemical characterization of Tv-EO as well as develop and validate a HSPM-gas chromatography (GC) method for the analysis of Tv-EO components encapsulated in NPs. Materials and Methods: Tv-EO was characterized by physicochemical analysis for relative density, refractive index, and optical rotation and analyzed by GC flame ionization detector and GC-mass spectrometry. The headspace-solid-phase microextraction-gas chromatography (HS-SPME-CG) validation was assessed, Tv-EO-NPs were prepared by nanoprecipitation, and its ...
During protracted myocardial ischemia, ATP depletion promotes Na+ accumulation in sympathetic terminals and prevents vesicular storage of norepinephrine (NE). This forces the reversal of the neuronal uptake1 transporter, and NE is massively released (carrier-mediated release). We had shown that histamine H3 receptors (H3Rs) modulate ischemic NE release in animals. We have now used a human model of protracted myocardial ischemia to investigate whether H3Rs may control carrier-mediated NE release. Surgical specimens of human atrium were incubated in anoxic conditions. NE release increased ∼7-fold within 70 min of anoxia. This release was carrier mediated because it was Ca++ independent and inhibited by the uptake1inhibitor desipramine. Furthermore, the Na+/H+exchanger (NHE) inhibitors ethyl-isopropyl-amiloride and HOE 642, and the Na+ channel blocker tetrodotoxin inhibited NE release, whereas the Na+ channel activator aconitine potentiated it. The selective H3R agonist imetit decreased NE ...
Brown leather wallet holding nine vials of medicinal tablets. Each vial has cork stopper and a printed label stating name and address of manufacturer and the contents which include strychnine Gm. 0.001, aconitine Gm. 0.0005, calomel Gm. 0.01, morphine sulphate Gm. 0.005, hyoscyamine Gm. 0.00025, digitalin Gm. 0.001, glonoin Gm. 0.00025, anti-constpation formula and anodyne formula for infants. Name and address of manufacturer is printed in gold lettering on interior surface of lid flap.. ...
Boiron Aconitum Napellus Helps Relieve Sudden Onset Fevers Accompanied by Dry SkinBoirons Aconitum Napellus 200CK, derived from wolfs bane, is formulated to help relieve a suddenly onset fever that coincides...
Synonyms for Aconitic in Free Thesaurus. Antonyms for Aconitic. 11 words related to aconite: Aconitum, genus Aconitum, Aconitum napellus, helmet flower, monkshood, helmetflower, Aconitum lycoctonum, wolfbane, wolfs bane.... What are synonyms for Aconitic?
106h. Aconitum hemsleyanum var. lasianthum W. T. Wang & L. Q. Li, Acta Phytotax. Sin. 25: 29. 1987. 毛萼瓜叶乌头 mao e gua ye wu tou Leaves cordate at base, distal ones without bulbils. Bracteoles and sepals pubescent on both surfaces. Upper sepal with indistinct abaxial hairs. Petals glabrous; spur more than 1.5 mm. Persistent style ca. 2.5 mm.. * Scrub; 3200--3300 m. W Sichuan (Muli Zang Zu Zizhixian).. ...
Aconitum anthora (Yellow monkshood). This species is an upright perennial. The leaves are rounded, deeply lobed and dark green. The flowers are produced in mid and late summer; racemes of pale yellow blooms.
Shop for Ollois Lactose Free Aconitum Napellus at Food 4 Less. Find quality products to add to your Shopping List or order online for Delivery or Pickup.
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Aconitum delphiniifolium image
description - heterophyllum- Roots biennial, paired, tuberous; whitish or grey. Stem erect, simple or branched, from 15-20 cm high. glabrous below, finely crispo-pubescent in the upper par
FeverUses:Main Indication: High fever of sudden onset with dry skinCommon Name: MonkshoodWarnings:Stop use and ask a doctor if symptoms persist for more than 3 days or worsen.If pregnant or breast-feeding,...
The letters HPUS indicate that this ingredient is officially included in the Homeopathic Pharmacopœia of the United States.. ...
Helsana ch trails. Concourslimo com. Bahnhofstrasse 4 ch 8810 horgen zürich. Winter seilpark interlaken. Aconitum napellus 15 ch avis. Baskethouse camp ch. Tutti ch kleider. Ch koordinaten umrechnen excel. Www okpunktstrich ch cards visa
MLA D-Tipper Pipette,120uL (Silver) Available in over 30 fixed volumes, from 5µL to 1000µL, the MLA D-Tipper is ideal for laboratories conducting repetitive.
Looking for Aconitum? Find out information about Aconitum. or any of several species of the genus Aconitum of the family Ranunculaceae , hardy perennial plants of the north temperate zone, growing wild or cultivated... Explanation of Aconitum
Aconitum napellus (Aconitum possibly from the greek for cone, napellus turnip) is known as the queen of the poisons, with the toxins aconite and aconitine present throughout the plant - the effects of which, which, in an interesting twist of poison counteracting poison, can be treated with atropine from Deadly Nightshade. Monkshood was often used as poison on arrows in Ancient Rome and China, and it is a close relative of the equally poisonous Aconitum Lycotonum, or Wolfsbane (so named for its ability to kill wolves). Death occurs within several hours of poisoning, with vomiting and nausea being early symptoms before death usually occurs by arrythmias. Despite their highly toxic nature, monkshood is popular as a garden plant, and if I have learned nothing else from this post its that the sanity of horticulturalist should probably be questioned ...
Presented by M di-T. ACONITINUM.. Aconitine (C27 H40 NO10) is obtained from the roots and stems of Aconitum napellus, L.. This must not be confounded with Morsons (English) Aconitine (same as Nepalin of Fl ckiger, or Napellin of Wigger, or Pseudo-aconitine of Huebschmann), which is obtained from Aconitum ferox.. Authorities. 1, Schroff; t, Toxicological, from Bird an others.. MIND. ► Intellect most perfect, and even vivid, [t]. ► Thought slow; long thinking impossible; all attention disturbed, [1]. ► Loss of sense, [1].. HEAD. ► Vertigo, [1]. ► Confusion of head very great, [1]. ► Headache, [t]. ► Pain in head and face more intense after the slightest mental exertion, [1].. EYES. ► Pupil dilated (both from internal and local use), [t]. ► Dimness of vision, [t].. EARS. ► Sense of pressure in ears, [1]. [10.] ► Roaring in ears, [1].. FACE. ► A peculiar drawing, pressive sensation in the cheeks on upper jaw, the forehead (region of nervus trigeminus), increase in ...
Species: Aconitum kusnezoffii. Common Name: Bei Wu Tou. Habitat: Aconitum kusnezoffii is native to E. Asia - N. China, N. Japan in Kamtschatka, Korea and Siberia. It grows on grassy slopes, grasslands, forests, forest margins, by streams at elevations of 2200 - 2400 metres.. Description:. Aconitum kusnezoffii is a perennial plant growing to 1.5 m (5ft). usually branched, glabrous, with leaves equally arranged along stem.Root stocks are conical or carrot-shaped, 2.5-5 cm, 7-12 mm in diam. Proximal cauline leaves withered at anthesis, middle ones shortly to long petiolate; petiole 3-11 cm, glabrous; leaf blade pentagonal, 9-16 × 10-20 cm, papery or subleathery, abaxially glabrous, adaxially sparsely retrorse pubescent, base cordate, 3-sect; central segment rhombic, apex acuminate, subpinnately divided or lobed; lateral segments obliquely flabellate, unequally 2-parted. Inflorescence terminal, 9-22-flowered; rachis and pedicels glabrous; proximal bracts 3-fid, others oblong or linear. Proximal ...
1-Naphthylamine, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, 3,4-Dihydroxyphenylacetic Acid, Abnormalities, Drug-Induced, Acetylcholine, Acetylcholinesterase, Aconitine, Acoustic Stimulation, Actins, Acute Disease, Acyltransferases, Adaptation, Physiological, Adenylate Cyclase, Adiponectin, Adipose Tissue, Administration, Cutaneous, Administration, Oral, Adolescent, Adrenergic alpha-2 Receptor Antagonists, Adrenergic alpha-Antagonists, Adult, Aerosols, Affect, Age Factors, Age of Onset, Aged, Aged, 80 and over, Aging, Air Pollutants, Alcohol Deterrents, Alcohol Drinking, Alcoholism, Alkaloids, Allosteric Regulation, alpha-Methyltyrosine, Alzheimer Disease, Amino Acids, Amino Acids, Branched-Chain, Amphetamine, Amygdala, Anabasine, Anal Canal, Analgesics, Analysis of Variance, Animals, Animals, Newborn, Animals, Suckling, Anthelmintics, Anti-Anxiety Agents, Anti-HIV Agents, Anticonvulsants, Antidepressive Agents, Antineoplastic Agents, Hormonal, Antioxidants, Antipsychotic Agents, ...
5. Aconitum columbianum Nuttall in J. Torrey & A. Gray, Fl. N. Amer. 1: 34. 1838. Roots tuberous, tuber distally not obviously bulblike, to 60 × 15 mm, parent tuber producing 1 (rarely 2) daughter tubers with connecting rhizome very short, i.e., tubers ±contiguous. Stems erect and stout to twining and reclining, 2-30 dm. Cauline leaves: blade deeply 3-5(-7)-divided, usually with more than 2 mm leaf tissue between deepest sinus and base of blade, 5-15 cm wide, segment margins variously cleft and toothed. Inflorescences open racemes or panicles. Flowers commonly blue, sometimes white, cream colored, or blue tinged at sepal margins, 18-50 mm from tips of pendent sepals to top of hood; pendent sepals 6-16 mm; hood conic-hemispheric, hemispheric, or crescent-shaped, 11-34mm from receptacle to top of hood, 6-26 mm wide from receptacle to beak apex.. Subspecies 2 (2 in the flora): moist areas, primarily in w North America, sporadic in e U.S.. Available information suggests that Aconitum columbianum ...
Aconitum, Monkshood available now at American Meadows. We provide creative gardeners with Aconitum, Monkshood and the highest quality perennials for the confidence they need to succeed. Place your order today and we guarantee 100% satisfaction. American Meadows, satisfying gardeners since 1981
This poisonous perennial graces many flower borders because of the beautiful, hooded, deep blue flowers borne on spikes in mid to late summer. Foliage is m
To the Editor -. We have read with great interest the paper by Leung et al. published in European Respiratory Journal [1], the correspondence by Russo et al. [2] and also the subsequent comment by the first group [3]. Both research teams are reporting increased ACE-2 expression in airways of current smokers and those with COPD with important implications for COVID-19 patients. Since ACE-2 has been shown to be the main receptor utilised by SARS-CoV-2 to enter the host cells [2], the authors conclude that nicotine is a risk factor for COVID-19 pandemic. Russo et al. [2] have shown that nicotine up-regulates ACE-2 through alpha7 nAChRs which are present in neuronal and non-neuronal cells. Leung et al. [3] provided further evidence in support of this hypothesis and propose the repurposing of alpha7-nAChR antagonists for the pandemic (e.g. methyllycaconitine, alpa-conotoxin), expecting that such treatment will alter ACE-2 expression and prevent SARS-CoV-2 entry.. While this hypothesis is based on ...
Qudah, T, Quek, G, Indurthi, D et al 2020, AE Succinimide, an Analogue of Methyllycaconitine, When Bound Generates a Nonconducting Conformation of the α4β2 Nicotinic Acetylcholine Receptor, A C S Chemical Neuroscience, vol. 11, no. 3, pp. 344-355. ...
Methyllycaconitine (MLA, 1) is a novel, potent probe for mammalian and insect nicotinic acetylcholine receptors (nAChR) and displays remarkable selectivity toward neuronal [125I]-alpha-bungarotoxin (alpha BgTX) binding sites that correspond to alpha 7-type nAChR in mammalian brain. We have shown that, among a number of selected norditerpenoid alkaloids, elatine (2) and nudicauline (3) are equipotent with, or better than, MLA (1) in binding to brain [125I]-alpha BgTX binding sites, with IC50 values of 6.1, 1.7, and 7.6 nM, respectively. The 2-((S)-methylsuccinimido)benzoyl moiety of these ligands is crucial for high-affinity binding, whereas structural modifications to the norditerpenoid core of the ligand can be tolerated without loss of activity or selectivity. In addition to MLA (1), elatine (2), and nudicauline (3), we have examined lycoctonine (4), inuline (6), lappaconitine (7), N-desacetyllappaconitine (8), delsoline (10), delcorine (11), deltaline (12), condelphine (13), and karacoline (14). This
The extremely potent and selective nicotinic acetylcholine receptor antagonist methyllycaconitine, MLA, and related norditerpene alkaloids are finding increasing use as neurochemical probes and as targets for structure-activity relationship studies. In this work, an assay procedure for MLA which utilises ion suppression reverse-phase HPLC with UV absorbance detection at 270 nm is described. The method detected 280 ng MLA on column.
Aconite has been understood as a poison from ancient times, and is frequently represented as such in fiction. In Greek mythology, the goddess Hecate is said to have invented aconite,[39] which Athena used to transform Arachne into a spider.[40] Also, Medea attempted to poison Theseus with a cup of wine poisoned with wolfs bane.[41] The kyōgen (traditional Japanese comedy) play Busu (附子, Dried aconite root),[42] which is well-known and frequently taught in Japan, is centered on dried aconite root used for traditional Chinese medicine. Taken from Shasekishu, a 13th-century anthology collected by Mujū, the story describes servants who decide that the dried aconite root is really sugar, and suffer unpleasant though nonlethal symptoms after eating it.[43] Shakespeare, in Henry IV Part II Act 4 Scene 4 refers to aconite, alongside rash gunpowder, working as strongly as the venom of suggestion to break up close relationships. In BBC drama Shakespeare and Hatherway, series 2, episode 9, a ...
The genus Aconitum in the flora of Slovakia is represented by subgenera Aconitum, Lycoctonum and Anthora. Among them the subgenus Aconitum is the richest and includes sections Aconitum and Cammarum DC., as well as nothosection Acomarum Starmühl. (sect. Aconitum × sect. Cammarm). It includes next taxa: 1) A. firmum Rchb. (subsp. firmum,subsp. moravicum Skalický, as well as it should includes contraversive subsp. maninense (Skalický) Starmühl. in Starmühl. & Mitka and nsubsp. paxii Starmühl. in Starmühl. & Mitka); 2) A. ×cammarum L. em. Fries; 3) A. variegatum L. subsp. variegatum; 4) A. lasiocarpum (Rchb.) Gáyer (subsp. lasiocarpum and subsp. kotulae (Pawł.) Starmühl. & Mitka); 5) A. degenii Gáyer subsp. degenii.. The second subgenus Lycoctonum (DC.) Peterm. is represented by: 1) A. moldavicum Hacq. (subsp. moldavicum, subsp. hosteanum (Schur) Graebn. & P. Graebn., subsp. simonkaianum (Gáyer) Starmühl.); 2) A. lycoctonum L. em. Koelle subsp. vulparia (Rchb.) Nyman; 3) controversive ...
Aconite (Aconitum Napellus) is a natural homeopathic remedy.In homeopathy, aconite is used for fear, anxiety, and restlessness, fever symptoms from exposure to dry, cold weather or very hot weather; tingling, coldness, and numbness; influenza or colds with congestion; and headaches.
Propecia horror stories - Consult your doctor if you are unable to assume caregiving role of antidysrhythmics pharmacologic blockade sodium potassium calcium class channels channels sodium channel openers aconitine andromedotoxin ciguatoxin veratridine restores the sinus node is regulated by controlling its absorption from the family that promotes the development of a serious illness childbirth stopping the oral bioavailability greater than 80 years of age reported annually to us poison centersmon name botanical name african violet willow species elderberry sanguinaria, bloodroot umbrella tree black mustard cabbage cactus caladium crown ower tea, green tea renal, carcinogenic neurologic cardiac cardiac, neurologic oxytocic, cardiovascular gastrointestinal hepatic. If your symptoms need urgent assessment in hospital. Studies in several organs.
Methyllycaconitine (MLA) is a diterpenoid alkaloid found in many species of Delphinium (larkspurs). In common with many other diterpenoid alkaloids, it is toxic to animals, although the acute toxicity varies with species. Early research was focused on identifying, and characterizing the properties of methyllycaconitine as one of the principal toxins in larkspurs responsible for livestock poisoning in the mountain rangelands of North America ...
Botanical Name : Aconitum violaceum Family : Ranunculaceae Genus : Aconitum Tibetan Common Name:: bdud rtsi lo ma, bong nga nag po (Amrita leaves, black
We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivative
Fired Earth Aconite Yellow Matt Emulsion Paint 2.5L - B&Q for all your home and garden supplies and advice on all the latest DIY trends
Gardeners are always looking for signs of spring. Although the calendar tells us it is officially spring, Mother-Nature can sometimes send mixed messages.
Thank you for your interest in spreading the word about The BMJ.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
These flowering perennials are Deciduous: Cut back stems close to ground level from late February through to the end of March. Cut stems can be left on border as natural mulch or composted.. ...
Flower bilateral; sepals 5, petal-like, upper 1 , others, hooded, generally enclosing upper 2 petals and stamens, tip generally rounded to beaked; petals 2 5, upper 2 clawed, blades generally inflated, tip spurred, lower 3 ,, sepals, scale-like, or 0; pistils generally ...
Homoeopathy is all about finding the most similar remedy, and we are here to introduce everybody to the complex science and essential concepts of complementary health practice through homeopathy.
18-O-2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoyllycoctonine: alkaloid from the roots of Aconitum pseudo-laeve var. erectum; structure in first source
Classification for Kingdom Plantae Down to Species Aconitum ferox Wall. ex Ser. Click on names to expand them, and on P for PLANTS profiles ...
How to Cite an Article in MLA Style. Citations let your readers know exactly where to find the sources youve used for an academic paper. If youre writing a paper for a literature or humanities class, chances are youll be using the MLA...
Exclusive Interview: जानिए Pakistan से आए Ex MLA Baldev Kumar पर Dharamsot को क्यों है शक#DainikSavera, #punjabinews
Compounds related to aconitine are widely studied for their properties in biological systems and these have been reviewed. For ... which is the same as in aconitine and this is reflected in its preferred IUPAC name. Gigactonine was reported in 1978 after its ...
Compounds related to aconitine are widely studied for their properties in biological systems and these have been reviewed. For ... polycyclic ring system containing nineteen carbon atoms and one nitrogen atom in these compounds is the same as in aconitine ...
Aconitine "Monkshood". AACC.org. Retrieved 9 November 2018. Rahman, A, et al, New Norditerpenoid Alkoids from Aconitum ... The Pharmacology of Pseudaconitine and Japaconitine considered in relation to that of Aconitine, 1901 Tsudaan Y., Marion L., ...
... (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure. ...
... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
A channel that is "inwardly-rectifying" is one that passes current (positive charge) more easily in the inward direction (into the cell) than in the outward direction (out of the cell). It is thought that this current may play an important role in regulating neuronal activity, by helping to stabilize the resting membrane potential of the cell. By convention, inward current (positive charge moving into the cell) is displayed in voltage clamp as a downward deflection, while an outward current (positive charge moving out of the cell) is shown as an upward deflection. At membrane potentials negative to potassium's reversal potential, inwardly rectifying K+ channels support the flow of positively charged K+ ions into the cell, pushing the membrane potential back to the resting potential. This can be seen in figure 1: when the membrane potential is clamped negative to the channel's resting potential (e.g. -60 mV), inward current flows (i.e. positive charge flows into the cell). However, when the ...
... has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.[1] How this effect is mediated and to what extent this mechanism is involved in the anxiolytic and analgesic effects of kavalactones on the central nervous system is unknown. Kavain's pharmacological activities have not been sufficiently investigated, and neither its effect as a serotonin reuptake inhibitor nor its monoamine (norepinephrine) uptake inhibitions and activation of NMDA receptors have been confirmed. The mechanism behind the psychotropic, sedative, and anxiolytic actions of kavain and related kavalactones is still debated. Direct binding to the benzodiazepine/flumazenil binding site of the GABA-A receptor does not occur with kavain enantiomers.[2] Many studies involved kava extracts from different plant parts and are, therefore, not applicable to kavain itself. In 2016, kavain was shown to bind at the α4β2δ GABAA receptor and ...
... has a potential for drug interactions; caution should be used in combining other medicines with it, including other antiepileptics and mood stabilizers.[12] Lower levels of carbamazepine are seen when administrated with phenobarbital, phenytoin, or primidone, which can result in breakthrough seizure activity. Carbamazepine, as a CYP450 inducer, may increase clearance of many drugs, decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects.[19] Drugs that are more rapidly metabolized with carbamazepine include warfarin, lamotrigine, phenytoin, theophylline, and valproic acid.[12] Drugs that decrease the metabolism of carbamazepine or otherwise increase its levels include erythromycin,[20] cimetidine, propoxyphene, and calcium channel blockers.[12] Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies.[12] As a drug that induces ...
... selectively binds to sulfonylurea receptors (SUR-1) on the surface of the pancreatic beta-cells. It was shown to provide cardiovascular protection as it does not bind to sulfonylurea receptors (SUR-2A) in the heart.[10] This binding effectively closes these K+ ion channels. This decreases the efflux of potassium from the cell which leads to the depolarization of the cell. This causes voltage dependent Ca2+ ion channels to open increasing the Ca2+ influx. The calcium can then bind to and activate calmodulin which in turn leads to exocytosis of insulin vesicles leading to insulin release.[citation needed] The mouse model of MODY diabetes suggested that the reduced gliclazide clearance stands behind their therapeutic success in human MODY patients, but Urbanova et al. found that human MODY patients respond differently and that there was no consistent decrease in gliclazide clearance in randomly selected HNF1A-MODY and HNF4A-MODY patients.[11] Its classification has been ambiguous, as ...
... has several uses including the treatment of abnormal heart rhythms or arrhythmias, chronic pain, and myotonia. In general when treating arrhythmias, mexiletine is reserved for use in dangerous heart rhythm disturbances such as ventricular tachycardia.[2] It is of particular use when treating arrhythmias caused by long QT syndrome.[3] The LQT3 form of long QT syndrome is amenable to treatment with mexiletine as this form is caused by defective sodium channels that continue to release a sustained current rather than fully inactivating, however other forms of long QT syndrome can also be treated with this medication.[3] Mexiletine has been used to treat chronic pain and may also be used to treat muscle stiffness resulting from myotonic dystrophy (Steinert's disease) or nondystrophic myotonias such as myotonia congenita (Thomsen syndrome or Becker syndrome).[4][5] ...
... is available as a generic medication and usually not too expensive.[7] Wholesale it costs between US$0.003 and US$0.15 per dose.[8] A month of treatment is about US$30 in the United States.[2] Since September 2012, the marketing licence in the UK has been held by Flynn Pharma Ltd, of Dublin, Ireland, and the product, although identical, has been called Phenytoin Sodium xxmg Flynn Hard Capsules. (The xxmg in the name refers to the strength-for example "Phenytoin sodium 25 mg Flynn Hard Capsules").[49] The capsules are still made by Pfizer's Goedecke subsidiary's plant in Freiburg, Germany and they still have Epanutin printed on them.[50] After Pfizer's sale of the UK marketing licence to Flynn Pharma, the price of a 28-pack of 25 mg phenytoin sodium capsules marked Epanutin rose from 66p (about $0.88) to £15.74 (about $25.06). Capsules of other strengths also went up in price by the same factor-2384%,[51] costing the UK's National Health Service an extra £43 million (about $68.44 ...
Li, Xiaodong; Gu, Liwei; Yang, Lan; Zhang, Dong; Shen, Jianying (2017). "Aconitine: A potential novel treatment for systemic ... Toxicity of pristane alleviated by aconitine. "pristane - Compound Summary". PubChem Compound. USA: National Center for ...
Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Poisoning may also occur following picking the leaves without wearing gloves; the aconitine toxin is absorbed easily through ... Treatment is similar to poisoning caused by oral ingestion.[citation needed] Aconitine is a potent neurotoxin that opens ... 19th-century illustration Model, Botanical Museum Greifswald Aconitum napellus - MHNT Aconitine: Raw Fu Zi, 0.004%; prepared Fu ...
Aconitine is a potent neurotoxin and cardiotoxin that causes persistent depolarization of neuronal sodium channels in ... Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Successful use of charcoal hemoperfusion has been claimed in patients with severe aconitine poisoning. Severe toxicity is not ... Monkshood and other members of the genus Aconitum contain substantial amounts of the highly toxic aconitine and related ...
Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Poisoning may also occur following picking the leaves without wearing gloves; the aconitine toxin is absorbed easily through ... The plant's chief toxic component, aconitine, is a potent neurotoxin that opens tetrodotoxin sensitive sodium channels. It ... Aconites have been used more recently in murder plots; they contain the chemical alkaloids aconitine, mesaconitine, ...
Did the High Priest Alcimus die of acute aconitine poisoning? This article incorporates text from a publication now in the ...
Andre Noble, 25, Canadian television and film actor, aconitine poisoning. Allu Ramalingaiah, 81, Indian comedian. Adolph ...
... the highly toxic alkaloid aconitine. Aconitine is easily absorbed through the skin, eyes and through the lining of the nose; ... The Chinese also used aconitine both for hunting and for warfare. Birthworts (family Aristolochiaceae) are often used to treat ...
Victims of aconitine poisoning suffer severe vomiting, and often become paralysed. Their organs stop working and they die from ... The case was also unusual, as the last prosecution for murder using aconitine was that of George Henry Lamson in 1882.[citation ...
... is poisonous due to the presence of alkaloids like aconitine. Currently 2 subspecies are accepted: Aconitum ...
... is poisonous due to the presence of alkaloids like aconitine. The Plant List (KEW): Aconitum tauricum (2018- ...
... aconitine and angelicotoxin. When consumed in sufficient quantity, tsūsensan produces a state of general anesthesia and ...
With Ludwig Hesse, he isolated the alkaloids atropine, aconitine, colchicine and hyoscyamine. In 1831 he was the first to ...
The active ingredients in tsūsensan were scopolamine, hyoscyamine, atropine, aconitine and angelicotoxin. When consumed in ...
Wolfgang Bücherl and Eleanor Buckley "ACONITINE - National Library of Medicine HSDB Database". toxnet.nlm.nih.gov. LD50 for ...
... batrachotoxin and aconitine. Experiments utilizing squid axonal membranes indicate that sodium channel binding likely occurs on ...
Police found thallium in his pocket and antimony, thallium and aconitine in his home. They also discovered a detailed diary ...
Plants of the aconitum genus contain the neurotoxin aconitine and in the case of Aconitum ferox; an extremely toxic alkaloid ...
Harold takes them; poisoned with aconitine, Harold dies whilst being watched taking the tablets by Lady Alice, his wife. Lucy ...
South Korea E. cilicica E. longistipitata E. pinnatifida, Mount Ibuki, Japan Aconitum Aconitine Schipcz, O. in Fl. U.S.S.R.,7 ...
aconitina; Finlandia. Descriptores (secundarios). efectos cardiol gicos; absorci n cut nea; etiquetado; limitaci n de la ...
Aconitine is also present in Yunnan Baiyao, a proprietary traditional Chinese medicine. Aconitine was previously used as an ... Aconitine is a C19-norditerpenoid, based on its presence of this C18 carbon. It is barely soluble in water, but very soluble in ... If aconitine is heated in its dry state, it undergoes a pyrolysis to form pyroaconitine ((1α,3α,6α,14α,16β)-20-ethyl-3,13- ... The binding of aconitine to the channel also leads to the channel to change conformation from the inactive state to the active ...
a) control; b)1 µM aconitine; c) 5 µM aconitine; d) 10 µM aconitine. ... Effect of aconitine on APD in rat ventricular myocytes. A. a) Representative recordings of APD. b) Effect of aconitine on APD50 ... Effects of aconitine on intracellular [Ca2+]i. Aconitine (1 μM) has no effect on the resting level of FI in the presence or ... 2, aconitine accelerated the activation of ICa-L and delayed the inactivation of ICa-L. So aconitine increased Ca2+ influx ...
Find out information about aconitine. C34H47O11N A poisonous, white, crystalline alkaloid compound obtained from aconites such ... aconitine. Also found in: Dictionary, Medical, Wikipedia. aconitine. [ə′kän·ə‚tēn] (pharmacology) C34H47O11N A poisonous, white ... Aconitine , Article about aconitine by The Free Dictionary https://encyclopedia2.thefreedictionary.com/aconitine ... Aconitine is contained in the roots of aconite, a blue or yellow flower with green leaves related to the buttercup. ...
Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and ... Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show ... We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine ... that aconitine may be a useful anticancer drug in the future. ... The anti-tumor effect of aconitine in melanoma cell line B16 ...
"Aconitine" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Aconitine" by people in this website by year, and whether " ... Below are the most recent publications written about "Aconitine" by people in Profiles. ...
The analytical reference, aconitine, was quantified at 238 nm. The retention time of aconitine was about 42.54 min. The linear ... The developed HPLC method is accurate and precise and it can be successfully applied for the determination of aconitine in ... μg/mL for aconitine with respect to peak area. The limit of detection and limit of quantitation values were found to be 0.03 μg ... method has been developed and validated for the analysis of aconitine in marketed ayurvedic taila (oil) formulations containing ...
China Aconitine Suppliers, provide quality Aconitine product and the products related with China Aconitine - natural-chem ... Chinachemnet , Sign in , Join NowAconitine Manufacturers, China Aconitine Suppliers, China Aconitine Exporters ... Details for China Aconitine. Aconitine 302-27-2. Category :. Pharmaceuticals and Biochemicals. ...
Barium chloride/aconitine was intraperitoneally injected to induce ventricular arrhythmias. Normal saline was administered to ... In the barium chloride/aconitine-induced ventricular arrhythmia model, terfenadine and amiodarone did not only similarly delay ... Comparative study of the protective effects of terfenadine and amiodarone on barium chloride/aconitine-induced ventricular ... the onset time of arrhythmias induced by barium chloride (all P,0.05), but also increased the cumulative dosage of aconitine ...
Aconitine as well as Lycaconitine are contained in Aconitum species, which are part of the poisonous buttercup plant family. ... Aconitine. Aconitine as well as Lycaconitine are contained in Aconitum species, which are part of the poisonous buttercup plant ... Aconitine. Lycaconitine. Aconite effects: Aconite poisoning is said to cause a feeling of wearing a fur or a feather coat. ... Aconitine does not effect the cerebral functions. The patient may fall into a coma only during the very last stage or remains ...
... - AHPRA Registered Chinese Medicine Practitioner, Acupuncture, Chinese Herbal Medicine, Remedial Massage, Chinese ... 其中以aconitine(烏頭鹼)毒性最強,0.2mg能使人中毒,3~4mg可致死亡。 ... 其中有毒為aconitine(烏頭鹼)、mesaconitine(中烏頭鹼
We are Professional Manufacturer of Molar Mass Aconitine company, Factory & Exporters specialize in Molar Mass Aconitine wiht ... Find Molar Mass Aconitine Manufacturers & Suppliers from China. ... mass of aconitine fleur aconitine say aconitine aconitine what ... Molar Mass Aconitine molar mass aconitine molecular mass of aconitine fleur aconitine say aconitine aconitine what is the molar ... Molar Mass Aconitine - manufacturer, factory, supplier from China. (Total 1 Products for Molar Mass Aconitine) ...
Aconitine and other Aconitum alkaloids are highly poisonous cardio-toxins and neurotoxins present in all parts of the plants of ... In Asia, aconitine poisoning is common because of the continued use of aconite roots in traditional medicine as an analgesic, ... Aconitine binds to sodium channels and prolongs their open state, favoring Na+ influx into the cytosol. The associated increase ... Aconitine and other Aconitum alkaloids fall within the categories of highly poisonous cardiotoxins and neurotoxins. They are ...
Chengdu Biopurify offers Aconitine [302-27-2] - Synonym name: Catalogue No.: BP0121 Cas No.:... Customizes high quality ...
Clinical features and management of herb-induced aconitine poisoning.. Ann Emerg Med. . 2004. ;. 43. :. 574. -. 9. .. 3. ... Keywords: aconite, aconitine herb, bidirectional ventricular tachycardia, overdose, cardiotoxic INTRODUCTION. Aconitum plant ... Aconitine binds to the sodium channel with high affinity and causes the channel to remain in an active state. This results in ... Aconitine and similar alkaloids bind to the open state of voltage-sensitive sodium channels in excitable tissue, such as the ...
Aconitine binds with sodium channels, changing the conformation to an activated state and therefore, prolonging depolarization ... Aconitine - the queen of poison. Natural toxin Aconitine binds with sodium channels, changing the conformation to an activated ... The content of aconitine in different Aconitum species is in the range of 17- 4846 µg g-1, being the highest concentration ... Aconitine is present species of the genus Aconitum (e.g. monkshood), Delphinium (e.g. larkspur) and Consolida. These three ...
We are Professional Manufacturer of What Is The Use Of Aconitine company, Factory & Exporters specialize in What Is The Use Of ... Find What Is The Use Of Aconitine Manufacturers & Suppliers from China. ... mass of aconitine the history of aconitine action of aconitine aconite vs aconitine aconite aconitine synthesis of aconitine ... mass of aconitine the history of aconitine action of aconitine aconite vs aconitine aconite aconitine synthesis of aconitine ...
Aconitine is used in China as an analgesic and blood coagulant. However, aconitine contains high cardiotoxicity which could ... Tags: aconitine, calcium regulatory, Chinese medicine, glucyrrhetinic acid, goodhealth, goodmedicine, goodscience, healing ... A team of researchers from Zhejiang Chinese Medical University in China studied whether the active components - aconitine, ... More news on aconitine Licorice root for heart health? When combined with other herbal compounds, it regulates calcium proteins ...
Cardiovascular aspects of aconitine poisoning Woo-Shik KIM; Seong-Shik LIM; Heung-Sun KANG; Chung-Whee CHOUE; Kwon-Sam KIM; ... Aconitine and its related alkaloids can cause toxic effects and even fatal poisoning. These cases point to the need for strict ... Aconitine and its related alkaloids are known cardiotoxins with no therapeutic role in modern western medicine. We have studied ... However, one case of acute aconitine poisoning had been dead of cardiac arrest due to ventricular fibrillation. CONCLUSION:. ...
Dihydropyridine (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure. ...
Carbamazepine (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
Aconitine had a significant pain relieving effect, which was similar to carbamazepine, in a dose-dependent manner. Aconitine ... A significant reduction in motor coordination was noted for the higher doses of aconitine which was similar with the 40 and 80 ... An Effective Phytoconstituent Aconitine: A Realistic Approach for the Treatment of Trigeminal Neuralgia ... This study was aimed at investigating the effects of aconitine in a rat model of trigeminal neuralgia pain. Infraorbital nerve ...
Because of the popularity of beta-lactam drugs, certain bacteria have been able to develop counter-measures to traditional drug therapies. An enzyme called beta-lactamase is present in many different types of bacteria, which serves to break the beta lactam ring, which effectively nullifies the antibiotics effectiveness. An example such enzyme is the NDM-1 discovered in 2009.. As a response to bacterial resistance to beta-lactam drugs, there are drugs, such as Augmentin/CLA, that are designed to disable the beta-lactamase enzyme. Augmentin/CLA (FGP) is made of amoxicillin, a beta-lactam antibiotic, and clavulanic acid, a beta-lactamase inhibitor. The clavulanic acid is designed to overwhelm all beta-lactamase enzymes, bind irreversibly to them, and effectively serve as an antagonist so that the amoxicillin is not affected by the beta-lactamase enzymes.. Full article ▸. ...
The mucous membranes (or mucosae; singular mucosa) are linings of mostly endodermal origin, covered in epithelium, which are involved in absorption and secretion. They line cavities that are exposed to the external environment and internal organs. They are at several places continuous with skin: at the nostrils, the mouth, the lips, the eyelids, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and glands is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus.. The glans penis (head of the penis) and glans clitoridis, along with the inside of the prepuce (foreskin) and the clitoral hood, are mucous membranes. The urethra is also a mucous membrane. The secreted mucus traps the pathogens in the body, preventing any further activities of diseases.. ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
p,,b,OBJECTIVE,/b,To find out hydrolysis regularity of aconitine.,/p,,p,,b,METHOD,/b,Aconitine was air-tighted and hydrolyzed ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Aconitine / Water / Chemistry / Chromatography, High Pressure ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Aconitine / Water / Chemistry / Chromatography, High Pressure ... Aconitine , Chemistry , Chromatography, High Pressure Liquid , Methods , Hydrolysis , Spectrometry, Mass, Electrospray ...
Pharmaceuticals, medical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides ...
Unigenes annotated as possible rate-determining steps of an aconitine-type biosynthetic pathway were highly expressed in the ... Unigenes identified in this study are strong candidates for aconitine-type diterpene alkaloid biosynthesis, and will serve as ... carmichaelii has shown accumulation of numerous bioactive metabolites including aconitine and aconitine-type diterpene ... carmichaelii has shown accumulation of numerous bioactive metabolites including aconitine and aconitine-type diterpene ...
CIS 88-45 Aconitine Akonitiini [en finland s]. Toxicity: LD50 = 295mg/kg. Skin absorbtion, inhalation and ingestion of the ...
BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVisions products are currently being sold in more than 60 countries worldwide.
  • In addition, Radix Aconiti lateralis Preparata contains very small amounts of the aconitum alkaloids, such as aconitine , mesaconitine, and hypaconitine, which are highly toxic but can be hydrolyzed to the more active but less toxic alkaloids, including benzoylaconine, benzoylmesaconine, and benzoylhypaconine that have significant anti-inflammatory and antinociceptive activities (Suzuki et al. (thefreedictionary.com)
  • Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine. (thefreedictionary.com)
  • Like many other alkaloids, the basic nitrogen atom in one of the six-membered ring structure of aconitine can easily form salts and ions, giving it affinity for both polar and lipophilic structures (such as cell membranes and receptors) and making it possible for the molecule to pass the blood-brain barrier. (wikipedia.org)
  • Aconitine and other Aconitum alkaloids are highly poisonous cardio-toxins and neurotoxins present in all parts of the plants of the Aconitum genus (aconite). (e-arrhythmia.org)
  • Aconitine and other Aconitum alkaloids fall within the categories of highly poisonous cardiotoxins and neurotoxins. (e-arrhythmia.org)
  • The cardiotoxicity and neurotoxicity of aconitine and related alkaloids is due to their interactions with voltage-sensitive sodium channels in the cell membranes of excitable tissues, including myocardium, nerves, and muscles [ 2 ]. (e-arrhythmia.org)
  • Aconitum plant species, also known as aconite, contain aconitine and other related alkaloids that are potent cardiotoxins and neurotoxins. (smj.org.sg)
  • Apart from aconitine, plants of this family produce different alkaloids. (ku.dk)
  • E.g., genus Aconitum produces nine different alkaloids where aconitine is the most relevant explaining the toxicity of this plant. (ku.dk)
  • Aconitine and its related alkaloids are known cardiotoxins with no therapeutic role in modern western medicine . (bvsalud.org)
  • Aconitine and its related alkaloids can cause toxic effects and even fatal poisoning . (bvsalud.org)
  • While extensive research on the characterization of metabolic extracts of A. carmichaelii has shown accumulation of numerous bioactive metabolites including aconitine and aconitine-type diterpene alkaloids, its biosynthetic pathway remains largely unknown. (mdpi.com)
  • Fu 1997 , Fu 2006 , Murayama 1991 , Murayama 1980 , Tai 1992 , Wang 2001 Other alkaloids may be produced by processing (eg, pyro-type aconitine alkaloids by heat Murayama 1991 or benzylaconines or aconines by hydrolysis). (drugs.com)
  • Aconitine and its congeners are considerably more toxic than aconine and related alkaloids. (drugs.com)
  • Extracts from plants containing toxic alkaloids, such as aconitine and tubocurarine, were used since antiquity for poisoning arrows. (scribd.com)
  • Publications] Naofumi Yoshioka: 'A case of aconitine poisoning with analysys of accnitine alkaloids by GC/SIM. (nii.ac.jp)
  • A toxin produced by the aconitum plant, aconitine has been used in the past as a drug for antipyretic, analgesic and antirheumatic treatments, as well as a neurotransmission inhibitor, in China and other countries [ 1 - 4 ]. (medsci.org)
  • A simple, sensitive, and selective high-performance liquid chromatographic (HPLC) method has been developed and validated for the analysis of aconitine in marketed ayurvedic taila (oil) formulations containing roots of Aconitum chasmanthum . (hindawi.com)
  • The developed HPLC method is accurate and precise and it can be successfully applied for the determination of aconitine in marketed ayurvedic oil formulations containing Aconitum chasmanthum . (hindawi.com)
  • Aconitine is an alkaloid toxin produced by the Aconitum plant, also known as devil's helmet or monkshood. (wikipedia.org)
  • Aconitine as well as Lycaconitine are contained in Aconitum species, which are part of the poisonous buttercup plant family. (wordpress.com)
  • Aconitine is present species of the genus Aconitum (e.g. monkshood), Delphinium (e.g. larkspur) and Consolida . (ku.dk)
  • The content of aconitine in different Aconitum species is in the range of 17- 4846 µg g -1 , being the highest concentration found in Aconitum pendulum . (ku.dk)
  • Aconitine is an alkaloid derived from various species of Aconitum. (drugs.com)
  • Aconitine is a very poisonous toxin that comes from the Aconitum plant. (wikipedia.org)
  • While the source of aconitine, especially in China, is usually Aconitum carmichaeli (chuanwu) or Aconitum kuznezoffii (caowu), the toxicity is similar to A. napellus . (poison.org)
  • Aconitum contains the toxin aconitine, which is highly poisonous. (upenn.edu)
  • Aconitine (C 27 H 40 NO 10 ) is obtained from the roots and stems of Aconitum napellus, L. (homeoint.org)
  • This must not be confounded with 'Morson's (English) Aconitine' (same as Nepalin of Fl ckiger, or Napellin of Wigger, or Pseudo-aconitine of Huebschmann), which is obtained from Aconitum ferox. (homeoint.org)
  • Aconitine is contained in the roots of aconite, a blue or yellow flower with green leaves related to the buttercup. (thefreedictionary.com)
  • In Asia, aconitine poisoning is common because of the continued use of aconite roots in traditional medicine as an analgesic, anti-inflammatory, and cardiotonic agent. (e-arrhythmia.org)
  • Aconitine is the alkaloid of aconite . (encyclopedia.com)
  • The toxic effects associated with aconitine (a poisonous alkaloid and the active principle of aconite) limit its ability to be used to treat bradycardia (slow heartbeat). (realfoodstore.com)
  • Severe poisoning has been reported after ingestion of aconitine (found in aconite) or processed and cured aconite. (realfoodstore.com)
  • There are also some, such as aconitine ( aconite ) which, although they are initially stimulating, then they are paralyzing. (botanical-online.com)
  • Aconitine (Fig. 1) is a C19-norditerpenoid ester alkaloid, with the presence of acetylester and benzoylester group in the position C8 and C14 of the diterpenoid skeleton, respectively. (ku.dk)
  • Unigenes identified in this study are strong candidates for aconitine-type diterpene alkaloid biosynthesis, and will serve as useful resources for further validation studies. (mdpi.com)
  • Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na + channels. (oup.com)
  • It contains aconitine and is the most poisonous of all the dangerous plants used to make flying ointments. (hubpages.com)
  • While the entire plant is highly toxic, especially in its raw state, the most poisonous compound is aconitine. (davidwolfe.com)
  • Aconitine is a well-known arrhythmogenic toxin and induces triggered activities through cardiac voltage-gated Na + channels. (medsci.org)
  • The major toxin in these plants is aconitine, which interacts with the voltage-gated sodium channels. (e-arrhythmia.org)
  • The high water solubility (629 mg/l) and log K ow of aconitine (0,13) suggest that this toxin might have implication on water quality. (ku.dk)
  • It contains a powerful toxin, aconitine, which can kill people who come into contact with it. (gardenersworld.com)
  • This was an unusual case of aconitine intoxication that mimicked acute myocardial infarction. (e-arrhythmia.org)
  • Here, I report an unusual case of acute aconitine intoxication manifesting as chest tightness and ST-segment elevation that mimicked acute myocardial infarction (AMI). (e-arrhythmia.org)
  • A dosis of 0.2 mg aconitine leads to severe intoxication, while dosis above 5 mg are letal for humans. (ku.dk)
  • During a six-year interval from 1990 to 1996, 9 cases of accidental herb-induced aconitine intoxication were managed in Kyung Hee university medical center . (bvsalud.org)
  • Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo . (mdpi.com)
  • The research team found that aconitine damaged the myocardial cell, reduced the survival rate and expression of NA + Ca 2+ exchangers and dihydropteridine reducta-?1, and enhanced the expression of ryanodine receptor type2. (naturalnews.com)
  • We investigated the effects of aconitine on intracellular Ca 2+ signals in rat ventricular myocytes and explored the possible mechanism of arrhythmogenic toxicity induced by aconitine. (medsci.org)
  • Combining aconitine with liquiritin and glycyrrhetinic acid increases efficiency and reduces toxicity, according to traditional Chinese medicine. (naturalnews.com)
  • The orthogonal combination of aconitine with liquiritin and glycyrrhetinic acid may regulate the expression of calcium regulatory proteins to inhibit the cytotoxicity of myocardial induced by aconitine, enhance the calcium regulatory adaption of myocardial cells, maintain the function of heart diastole and systole, and whence achieve the effect of toxicity reducing and efficacy enhancing," the researchers wrote. (naturalnews.com)
  • All patients developed symptoms of aconitine toxicity within 4 hours of herb ingestion . (bvsalud.org)
  • 5 self-assembled nanoparticles (NPs) of the licorice protein reduce the toxicity of aconitine by encapsulation. (nature.com)
  • Aconitine was previously used as an antipyretic and analgesic and still has some limited application in herbal medicine although the narrow therapeutic index makes calculating appropriate dosage difficult. (wikipedia.org)
  • Aconitine is used in China as an analgesic and blood coagulant. (naturalnews.com)
  • The Oriental herbal materials known as aconitine have long been used in oriental traditional medicine for their analgesic and antiinflammatory effects. (bvsalud.org)
  • Aconitine is an anti-inflammatory agent with therapeutic uses in oriental medicine as an analgesic and for treatment of stroke. (koreamed.org)
  • Animals exposed to DE had increased sympathetic modulation, prolonged ventricular depolarization, and shortened repolarization periods, and they developed arrhythmia at lower doses of aconitine than controls. (thefreedictionary.com)
  • However, aconitine contains high cardiotoxicity which could lead to severe arrhythmia, so its doses need to be regulated. (naturalnews.com)
  • effective against arrhythmia caused by aconitine? (adooq.com)
  • Sensitivity to aconitine-induced arrhythmia has been employed to examine the factors that increase the risk of such dysfunction. (bmj.com)
  • We used aconitine to test whether a single exposure to diesel exhaust (DE) would increase the risk of arrhythmia being triggered in hypertensive rats. (bmj.com)
  • Sensitivity to arrhythmia was measured as the threshold dose of aconitine required to produce ventricular premature beats (VPB), ventricular tachycardia (VT) and ventricular fibrillation (VF). (bmj.com)
  • Pre-exposure treatment of rats exposed to DE with a transient receptor potential A1 (TRPA1) antagonist prevented the heightened sensitivity to aconitine-induced arrhythmia. (bmj.com)
  • Ventricular arrhythmic models were developed using aconitine , barium chloride, and myocardial ischemia-reperfusion methods, Wenxin Granule was administered in progressively higher doses. (thefreedictionary.com)
  • Comparative study of the protective effects of terfenadine and amiodarone on barium chloride/aconitine-induced ventricular arrhythmias in rats: A potential role of terfenadine. (biomedsearch.com)
  • Barium chloride/aconitine was intraperitoneally injected to induce ventricular arrhythmias. (biomedsearch.com)
  • The Molar Mass Aconitine are very perfect and the company sales manager is warmful, we will come to this company to purchase next time. (dahepharma.com)
  • This is a very professional wholesaler, we always come to their company for procurement, good quality Molar Mass Aconitine and reasonable prices. (dahepharma.com)
  • Dedicated to strict quality manage and thoughtful buyer company, our experienced workers members are generally available to discuss your specifications and make certain full consumer gratification for Molar Mass Aconitine , molar mass aconitine , molecular mass of aconitine , Our mission should be to assist you build long-lasting interactions with the purchasers as a result of the ability of promotional solutions. (dahepharma.com)
  • for What Is The Use Of Aconitine , what is the use of aconitine , what is the molar mass of aconitine , Our merchandise are widely used in several industrial fields. (dahepharma.com)
  • Arrhythmogenesis was assessed 24 hr later by continuous intravenous infusion of aconitine , an arrhythmogenic drug, while heart rate (HR) and electrocardiogram (ECG) were monitored. (thefreedictionary.com)
  • Arrhythmogenesis was assessed 24 h later in urethane-anaesthetised animals by continuous intravenous infusion of aconitine while heart rate (HR) and electrocardiogram (ECG) were monitored. (bmj.com)
  • A significant reduction in motor coordination was noted for the higher doses of aconitine which was similar with the 40 and 80 mg/kg doses of carbamazepine. (gazi.edu.tr)
  • There is a very low margin of safety between therapeutic and toxic doses of aconitine. (poison.org)
  • Rats exposed to DE successively developed VPB's, VT, and VF at significantly lower doses of aconitine than air-exposed animals. (bmj.com)
  • It was reported that arrhythmias induced by aconitine had a direct relationship with the activation of RyR 2 by disrupting intracellular Ca 2+ homeostasis [ 17 ]. (medsci.org)
  • However, one case of acute aconitine poisoning had been dead of cardiac arrest due to ventricular fibrillation . (bvsalud.org)
  • In Hong Kong, aconitine is responsible for the majority of serious poisonings from Chinese herbal preparations. (poison.org)
  • To better understand the cardiac toxicities of aconitine, it is of paramount importance to explore the underlying mechanisms of the arrhythmogenic effects caused by aconitine. (medsci.org)
  • Aconitine can interact with the voltage-dependent sodium-ion channels, which are proteins in the cell membranes of excitable tissues, such as cardiac and skeletal muscles and neurons. (wikipedia.org)
  • Acute aconitine poisoning causes a tickling and burning sensation, followed by paralysation of the tongue and mouth and disabled speech. (wordpress.com)
  • The frequency of the order in cardinal symptoms of acute aconitine poisoning was nausea or vomiting , irritability, chest discomfort, dizziness , etc. (bvsalud.org)
  • The toxicology service that was consulted suspected aconitine poisoning based on the patient's clinical presentation. (smj.org.sg)
  • To find out hydrolysis regularity of aconitine . (bvsalud.org)
  • The acetoxyl group at the c8 position can readily be replaced by a methoxy group, by heating aconitine in methanol, to produce a 8-deacetyl-8-O-methyl derivatives. (wikipedia.org)
  • A third cohort of rats in each exposure group was challenged with aconitine to assess sensitivity to arrhythmogenic challenge. (thefreedictionary.com)
  • Aconitine significantly reduced mechanical sensitivity in a dose-dependent manner. (gazi.edu.tr)
  • In conclusion, aconitine increased the cytosolic [Ca 2+ ] i by accelerating I Ca-L and changing the expression of NCX and SERCA2a. (medsci.org)
  • In conclusion, we show that aconitine may be a useful anticancer drug in the future. (mdpi.com)
  • In conclusion, the results indicate that aconitine with liquiritin and glycyrrhetinic acid may regulate the expression of calcium-regulated proteins to defend myocardial cells from damage. (naturalnews.com)
  • Aconitine binds with sodium channels, changing the conformation to an activated state and therefore, prolonging depolarization and causing multiple toxic effects. (ku.dk)
  • Aconitine binds to the channel at the neurotoxin binding site 2 on the alpha-subunit. (wikipedia.org)
  • Aconitine suppresses the conformational change in the sodium-ion channel from the active state to the inactive state. (wikipedia.org)
  • The arrhythmogenic effects of aconitine include the induction of ventricular tachycardia (VT), torsades de pointes and ventricular fibrillation (VF) [ 8 ]. (medsci.org)
  • The primary component of Radix aconiti carmichaeli is aconitine, which is responsible for the pharmacological activity. (naturalnews.com)
  • Aconitine may be an alternative pharmacological agent for the control of trigeminal neuralgia pain. (gazi.edu.tr)
  • At higher concentrations (5 µM and 10 µM), aconitine induced triggered activities and delayed after-depolarizations (6 of 8 cases), which were inhibited by verapamil. (medsci.org)
  • However, in the clinic, Ca 2+ channel antagonists, such as verapamil, have been observed to have better therapeutic effects on aconitine-induced VTs rather than Na + channel antagonists, such as quinidine [ 13 , 14 ]. (medsci.org)
  • The myocardial cells were randomly divided into 12 groups - control, aconitine, nine different dose groups of orthogonal combined with aconitine, liquiritin, and glucyrrhetinic acid, and verapamil. (naturalnews.com)
  • A team of researchers from Zhejiang Chinese Medical University in China studied whether the active components - aconitine, liquiritin, and glycyrrhetinic acid - found in Radix aconiti carmichaeli and licorice could lead to the regulation of intracellular calcium homeostasis and calcium cycling, which could affirm their therapeutic properties. (naturalnews.com)
  • For example, the poison aconitine has no known antidote. (wikipedia.org)
  • One of the most famous poisonings accredited to aconitine , is that of the Roman Emperor Claudius, who died suddenly in 54 AD. (thefreedictionary.com)
  • Aconitine is also soluble in mixtures of alcohol and water if the concentration of alcohol is high enough. (wikipedia.org)
  • It may also cause a hallucination of ants crawling all over the fingers, hands and feet, followed by uncontrolled spasms and paralysation of the face muscles and a cold feeling, as if ice water ran through the veins, since aconitine stimulates the body's low temperature receptors. (wordpress.com)
  • In rat ventricular myocytes, the action potential duration was significantly prolonged by 1 µM aconitine. (medsci.org)
  • We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. (mdpi.com)
  • Plasma concentrations of aconitine supported poisoning by A. napellus . (poison.org)
  • The polycyclic ring system of this chemical compound contains nineteen carbon atoms and one nitrogen atom, which is the same as in aconitine and this is reflected in its preferred IUPAC name. (wikipedia.org)
  • However, the effects of aconitine on intracellular Ca 2+ signals were previously unknown. (medsci.org)
  • This study was aimed at investigating the effects of aconitine in a rat model of trigeminal neuralgia pain. (gazi.edu.tr)
  • Aconitine is the most dangerous of these toxins. (poison.org)
  • Aconitine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Aconitine can interact with voltage-dependent Na + channels and suppress the conformational change of Na + channels from the active state to the inactive state so that the membrane remains depolarized [ 1 , 9 , 10 ]. (medsci.org)