Sodium Channel Agonists
Ventromedial Hypothalamic Nucleus
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices. (1/219)1. Whole-cell clamp recordings of the compound synaptic current elicited by afferent stimulation of Schaffer collaterals showed that blockade of the NMDA, AMPA and GABAA receptor-mediated components by 6-nitro-7-sulphamoyl- benzo(f)quinoxaline-2,3-dione (NBQX), 3-((R)-2-carboxypiperazine-4-yl)propyl-1-phosphonate (R-CPP) and picrotoxin, respectively, left a small residual current in 39 out of 41 CA1 pyramidal neurones in organotypic cultures and 9 out of 16 CA1 cells in acutely prepared slices. 2. This current represented 2. 9 +/- 0.4 % of the compound evoked synaptic response in organoypic cultures and 1.4 +/- 0.5 % in slices. It was characterized by a slightly rectifying I-V curve and a reversal potential of 3.4 +/- 5. 1 mV. 3. This residual current was insensitive to blockers of GABAB, purinergic, muscarinic and 5-HT3 receptors, but it was essentially blocked by the nicotinic receptor antagonist d-tubocurarine (91 +/- 4 % blockade; 20 microM), and partly blocked by alpha-bungarotoxin (200 nM) and methyllycaconitine (10 nM), two antagonists with a higher selectivity for alpha7 subunit-containing nicotinic receptors (48 +/- 3 % and 55 +/- 11 % blockade, respectively). 4. The residual current was of synaptic origin, since it occurred after a small delay; its amplitude depended upon the stimulation intensity and it was calcium dependent and blocked by the sodium channel antagonist tetrodotoxin. 5. We conclude that afferent stimulation applied in the stratum radiatum evokes in some hippocampal neurones a small synaptic current mediated by activation of neuronal nicotinic receptors. (+info)
Nicotinic acetylcholine receptors assembled from the alpha7 and beta3 subunits. (2/219)Intracellular recordings were performed in voltage-clamped Xenopus oocytes upon injection with a mixture of cDNAs encoding the beta3 and mutant alpha7 (L247Talpha7) neuronal nicotinic acetylcholine receptor (nAChR) subunits. The expressed receptors maintained sensitivity to methyllycaconitine and to alpha-bungarotoxin but exhibited a functional profile strikingly different from that of the homomeric L247Talpha7 receptor. The heteromeric L247Talpha7beta3 nAChR had a lower apparent affinity and a faster rate of desensitization than L247Talpha7 nAChR, exhibited nonlinearity in the I-V relationship, and was inhibited by 5-hydroxytryptamine, much like wild type alpha7 (WTalpha7) nAChR. Single channel recordings in cell-attached mode revealed unitary events with a slope conductance of 19 picosiemens and a lifetime of 5 ms, both values being much smaller than those of the homomeric receptor channel. Upon injection with a mixture of WTalpha7 and beta3 cDNAs, clear evidence was obtained for the plasma membrane assembly of heteromeric nAChRs, although ACh could not activate these receptors. It is concluded that beta3, long believed to be an orphan subunit, readily co-assembles with other subunits to form heteromeric receptors, some of which may be negative regulators of cholinergic function. (+info)
Effects of Delphinium alkaloids on neuromuscular transmission. (3/219)The Delphinium alkaloids methyllycaconitine (MLA), nudicauline, 14-deacetylnudicauline (14-DN), barbinine, and deltaline were investigated for their effects on neuromuscular transmission in lizards. The substituent at C14 provides the only structural difference among the alkaloids MLA, nudicauline, 14-DN, and barbinine. Deltaline lacks the N-(methylsuccinyl)anthranilic acid at C18 common to the other four alkaloids. Each alkaloid reversibly reduced extracellularly recorded compound muscle action potential (CMAP) amplitudes in a concentration-dependent manner. The IC(50) values for CMAP blockade were between 0.32 and 13.2 microM for the N-(methylsuccinimido)anthranoyllycacotonine-type alkaloids and varied with the C14 moiety; the IC(50) value for deltaline was 156 microM. The slopes of the concentration-response curves for CMAP blockade were similar for each alkaloid except barbinine, whose shallower curve suggested alternative or additional mechanisms of action. Each alkaloid reversibly reduced intracellularly recorded spontaneous, miniature end-plate potential (MEPP) amplitudes. Alkaloid concentrations producing similar reductions in MEPP amplitude were 0.05 microM for 14-DN, 0.10 microM for MLA, 0.50 microM for barbinine, and 20 microM for deltaline. Only barbinine altered the time constant for MEPP decay, further suggesting additional or alternative effects for this alkaloid. MLA and 14-DN blocked muscle contractions induced by exogenously added acetylcholine. All five alkaloids are likely nicotinic receptor antagonists that reduce synaptic efficacy and block neuromuscular transmission. The substituent at C14 determines the potency and possibly the mechanism of nicotinic acetylcholine receptor blockade for MLA, nudicauline, 14-DN, and barbinine at neuromuscular synapses. The lower potency of deltaline indicates that the N-(methylsuccinyl)anthranilic acid at C18 affects alkaloid interactions with nicotinic acetylcholine receptors at neuromuscular junctions. (+info)
Cooperative activation of action potential Na+ ionophore by neurotoxins. (4/219)Four neurotoxins that activate the action potential Na+ ionophore of electrically excitable neuroblastoma cells interact with two distinct classes of sites, one specific for the alkaloids veratridine, batrachotoxin, and aconitine, and the second specific for scorpion toxin. Positive heterotropic cooperativity is observed between toxins bound at these two classes of sites. Tetrodotoxin is a noncompetitive inhibitor of activation by each of these toxins (KI = 4-8 nM). These results suggest the existence of three functionally separable components of the action potential Na+ ionophore: two regulatroy components, which bind activating neurotoxins and interact allosterically in controlling the activity of a third ion-transport component, which binds tetrodotoxin. (+info)
Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks. (5/219)Cholinergic control of the activity of human cerebral cortical circuits has long been thought to be accounted for by the interaction of acetylcholine (ACh) with muscarinic receptors. Here we report the discovery of functional nicotinic receptors (nAChRs) in interneurons of the human cerebral cortex and discuss the physiological and clinical implications of these findings. The whole-cell mode of the patch-clamp technique was used to record responses triggered by U-tube application of the nonselective agonist ACh and of the alpha7-nAChR-selective agonist choline to interneurons visualized by means of infrared-assisted videomicroscopy in slices of the human cerebral cortex. Choline induced rapidly desensitizing whole-cell currents that, being sensitive to blockade by methyllycaconitine (MLA; 50 nM), were most likely subserved by an alpha7-like nAChR. In contrast, ACh evoked slowly decaying whole-cell currents that, being sensitive to blockade by dihydro-beta-erythroidine (DHbetaE; 10 microM), were most likely subserved by an alpha4beta2-like nAChR. Application of ACh (but not choline) to the slices also triggered GABAergic postsynaptic currents (PSCs). Evidence is provided that ACh-evoked PSCs are the result of activation of alpha4beta2-like nAChRs present in preterminal axon segments and/or in presynaptic terminals of interneurons. Thus, nAChRs can relay inhibitory and/or disinhibitory signals to pyramidal neurons and thereby modulate the activity of neuronal circuits in the human cerebral cortex. These mechanisms, which appear to be retained across species, can account for the involvement of nAChRs in cognitive functions and in certain neuropathological conditions. (+info)
Anti-arrhythmic effects of sophoridine and oxysophoridine. (6/219)AIM: To compare the effects of oxysophoridine (Oxy) and sophoridine (Sop) on experimental arrhythmias and myocardial physiologic properties. METHODS: Arrhythmias were induced by drugs and myocardial ischemia. Physiologic properties were determined on isolated heart atria. RESULTS: Oxy 500 mg.kg-1 (1/6 LD50) decreased the incidence of ventricular arrhythmias induced by aconitine (P < 0.01), increased the threshold dose of ouabain-induced ventricular premature (VP, P < 0.05), ventricular tachycardia (VT, P < 0.05), ventricular fibrillation (VF, P < 0.01), and cardiac arrest, (P < 0.01). After i.v. Oxy 500 mg.kg-1 into the rats with ligation of left anterior descending coronary artery, the total numbers of ectopic beats were decreased (P < 0.05), the incidence of VF was lowered, and the duration of VT was shortened (P < 0.01). Oxy 250 mg.kg-1 (1/13 LD50) i.v. shortened the duration of arrhythmias induced by BaCl2 (P < 0.01) and delayed the onset of arrhythmias induced by chloroform-epinephrine (P < 0.05). Oxy produced dose-dependent positive inotropic effects in the isolated left atrial of guinea pigs, increased the concentration of epinephrine to elicit automaticity in left atria, decreased slightly the excitability, and prolonged the functional refractory period. Sop produced the similar effects on arrhythmias as Oxy. CONCLUSION: Oxy produced the similar anti-arrhythmic effects as Sop did at the equivalent effective dose. (+info)
Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons. (7/219)Nicotinic acetylcholine receptors (nAChRs) are expressed in the hippocampus, and their functional roles are beginning to be delineated. The effect of nAChR activation on the activity of both interneurons and pyramidal neurons in the CA1 region was studied in rat hippocampal slices. In CA1 stratum radiatum with muscarinic receptors inhibited, local pressure application of acetylcholine (ACh) elicited a nicotinic current in 82% of the neurons. The majority of the ACh-induced currents were sensitive to methyllycaconitine, which is a specific inhibitor of alpha7-containing nAChRs. Methyllycaconitine-insensitive nicotinic currents also were present as detected by a nonspecific nAChR inhibitor. The ACh-sensitive neurons in the s. radiatum were identified as GABAergic interneurons by their electrophysiological properties. Pressure application of ACh induced firing of action potentials in approximately 70% of the interneurons. The ACh-induced excitation of interneurons could induce either inhibition or disinhibition of pyramidal neurons. The inhibition was recorded from the pyramidal neuron as a burst of GABAergic synaptic activity. That synaptic activity was sensitive to bicuculline, indicating that GABA(A) receptors mediated the ACh-induced synaptic currents. The disinhibition was recorded from the pyramidal neuron as a reduction of spontaneous GABAergic synaptic activity when ACh was delivered onto an interneuron. Both the inhibition and disinhibition were sensitive to either methyllycaconitine or mecamylamine, indicating that activation of nicotinic receptors on interneurons was necessary for the effects. These results show that nAChRs are capable of regulating hippocampal circuits by exciting interneurons and, subsequently, inhibiting or disinhibiting pyramidal neurons. (+info)
Two distinct classes of functional 7-containing nicotinic receptor on rat superior cervical ganglion neurons. (8/219)Nicotinic acetylcholine receptors (nAChRs) that bind alpha-bungarotoxin (alpha Bgt) were studied on isolated rat superior cervical ganglion (SCG) neurons using whole-cell patch clamp recording techniques. Rapid application of ACh onto the soma of voltage clamped neurons evoked a slowly desensitizing current that was reversibly blocked by alpha Bgt (50 nM). The toxin-sensitive current constituted on average about half of the peak whole-cell response evoked by ACh. Nanomolar concentrations of methyllycaconitine blocked the alpha Bgt-sensitive component of the ACh-evoked current as did intracellular dialysis with an anti-alpha 7 monoclonal antibody. The results indicate that the slowly reversible toxin-sensitive response elicited by ACh arises from activation of an unusual class of alpha 7-containing receptor (alpha 7-nAChR) similar to that reported previously for rat intracardiac ganglion neurons. A second class of functional alpha 7-nAChR was identified on some SCG neurons by using rapid application of choline to elicit responses. In these cases a biphasic response was obtained, which included a rapidly desensitizing component that was blocked by alpha Bgt in a pseudo-irreversible manner. The pharmacology and kinetics of the responses resembled those previously attributed to alpha 7-nAChRs in a number of other neuronal cell types. Experiments measuring the dissociation rate of 125I-labelled alpha Bgt from SCG neurons revealed two classes of toxin-binding site. The times for toxin dissociation were consistent with those required to reverse blockade of the two kinds of alpha Bgt-sensitive response. These results indicate that rat SCG neurons express two types of functional alpha 7-nAChR, differing in pharmacology, desensitization and reversibility of alpha Bgt blockade. (+info)
Molecules | Free Full-Text | In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future.
Analgesic effects of lappaconitine in leukemia bone pain in a mouse model [PeerJ]
Bone pain is a common and severe symptom in cancer patients. The present study employed a mouse model of leukemia bone pain by injection K562 cells into tibia of mouse to evaluate the analgesic effects of lappacontine. Our results showed that the lappaconitine treatment at day 15, 17 and 19 could effectively reduce the spontaneous pain scoring values, restore reduced degree in the inclined-plate test induced by injection of K562 cells, as well as restore paw mechanical withdrawal threshold and paw withdrawal thermal latency induced by injection of K562 cells to the normal levels. Additionally, the molecular mechanisms of lappaconitines analgesic effects may be related to affect the expression levels of endogenous opioid system genes (POMC, PENK and MOR), as well as apoptosis-related genes (Xiap, Smac, Bim, NF-κB and p53). Our present results indicated that lappaconitine may become a new analgesic agent for leukemia bone pain management.
Study of alkaloids of the Siberian and Altai flora 13. Synthesis of alkynyllappaconitines<...
TY - JOUR. T1 - Study of alkaloids of the Siberian and Altai flora 13. Synthesis of alkynyllappaconitines. AU - Osadchii, S. A.. AU - Shults, E. E.. AU - Vasilevskii, S. F.. AU - Polukhina, E. V.. AU - Stepanov, A. A.. AU - Tolstikov, G. A.. PY - 2007/2/1. Y1 - 2007/2/1. N2 - The Sonogashira coupling of 5′-iodolappaconitine with prop-2-yn-1-ol, 2-methylbut-3-yn-2-ol, phenylacetylene, and 5-ethynylpyrimidine gave new lappaconitine derivatives containing an alkynyl fragment.. AB - The Sonogashira coupling of 5′-iodolappaconitine with prop-2-yn-1-ol, 2-methylbut-3-yn-2-ol, phenylacetylene, and 5-ethynylpyrimidine gave new lappaconitine derivatives containing an alkynyl fragment.. KW - Alkaloids. KW - Alkynes. KW - Alkynylation. KW - Cross-coupling. KW - Diterpenes. KW - Iodoarenes. KW - Lappaconitine. KW - Sonogashira reaction. UR - http://www.scopus.com/inward/record.url?scp=34547540930&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=34547540930&partnerID=8YFLogxK. U2 - ...
08 Increased risk of cardiac arrhythmia in rats exposed to diesel exhaust air pollution is mediated by the nociceptive...
Epidemiological studies demonstrate a significant association between arrhythmias and air pollution exposure. Sensitivity to aconitine-induced arrhythmia has been employed to examine the factors that increase the risk of such dysfunction. We used aconitine to test whether a single exposure to diesel exhaust (DE) would increase the risk of arrhythmia being triggered in hypertensive rats. We hypothesised that DE exposure increases the risk of arrhythmia due to sensory irritation during and after inhalation. Spontaneously hypertensive rats surgically implanted with radiotelemeters were exposed to 150 μg/m3 of DE or filtered air for 4 h. Arrhythmogenesis was assessed 24 h later in urethane-anaesthetised animals by continuous intravenous infusion of aconitine while heart rate (HR) and electrocardiogram (ECG) were monitored. Rats exposed to DE had lower HR when compared to air-exposed animals. Exposure to DE resulted in significantly shorter PR intervals, and significantly prolonged corrected QT ...
Time-Dependent Block of Ultrarapid-Delayed Rectifier K+ Currents by Aconitine, a Potent Cardiotoxin, in Heart-Derived H9c2...
Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na+ channels. However, it remains unknown whether it has any effects on K+ currents. The effects of ACO on ion currents in differentiated clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular myocytes were investigated in this study. In H9c2 cells, ACO suppressed ultrarapid-delayed rectifier K+ current (IKur) in a time- and concentration-dependent fashion. The IC50 value for ACO-induced inhibition of IKur was 1.4μM. ACO could accelerate the inactivation of IKur with no change in the activation time constant of this current. Steady-state inactivation curve of IKur during exposure to ACO could be demonstrated. Recovery from block by ACO was fitted by a single-exponential function. The inhibition of IKur by ACO could still be observed in H9c2 cells preincubated with ruthenium red (30μM). Intracellular dialysis with ACO (30μM) had no effects on IKur. IKur elicited by ...
George Henry Lamson - Wikipedia
George Henry Lamson (8 September 1852 - 28 April 1882) was an American doctor and murderer. In his early career he had been a volunteer surgeon in Romania and Serbia, and decorated for his work. He returned to England and practised in Bournemouth. He became addicted to morphine and his financial situation grew desperate. In 1881 he visited his 18-year-old brother-in-law Percy John, a hemiplegic, at his boarding school and gave him a slice of Dundee cake. He also gave him a capsule from a batch that were later tested and found to contain the poison aconitine, as recorded in the case history at Old Bailey Online. Lamson was tried in March 1882 with Montagu Williams acting for his defence: he was found guilty of murdering Percy in order to secure a share of the family inheritance. He had poisoned his victim with aconitine in the cake, a substance which Lamson had learnt about from Professor Robert Christison in university. Christison had taught that aconitine was undetectable but forensic science ...
Different Interaction between the Agonist JN403 and the Competitive Antagonist Methyllycaconitine with the Human α7 Nicotinic...
Diacetylkorseveriline | ≥99%(HPLC) | AdooQ®
Diacetylkorseveriline is an antiarrhythmic (classes i and iv)? belonging to a novel structural class. effective against arrhythmia caused by aconitine? cacl2? electric stimulation of the ventricles or ligature of the aorta, recommended dose for one cycle of experiment on mice: 3.0-30.0 mg/kg? intravenously.
MLA Micro D-Tipper Pipette Pipette VistaLab Technologies | Pipettes.com
Order MLA Micro D-Tipper Pipette Pipette VistaLab Technologies Manufacturer from a trusted supplier to chemistry & biology labs.
What trees will grow under pine trees?
Listing of the answers to the question: What trees will grow under pine trees? I understand that many plants wont survive under pine trees due to the oils in the needles. Which sorts of trees can thrive? Particularly in the Northeast US.
Aconite (Aconitum napellus) - Real Food Market & Deli
Acetylbenzoylaconin, aconite root, aconiti frus, Aconiti Herba, aconiti lateralis preparata, aconiti tuber, aconitine, aconitknollen, aconito, Aconitum angustius, Aconitum anthoroideum, Aconitumartemisiifolium, Aconitum austroyunnanense, Aconitum balfourii, Aconitum barbatum, Aconitumbrachypodum, Aconitum brunneum, Aconitum carmichaelii, Aconitum chasmanthum, Aconitumchilienshanicum, Aconitum columbianum, Aconitum coreanum, Aconitum episcopale, Aconitumferox, Aconitum flavum, Aconitum gymnandrum, Aconitum hemsleyanum, Aconitum japonicum, Aconitum karakolicum, Aconitum kongboense, Aconitum kusnezoffii, Aconitum longilobum, Aconitum moldavicum, Aconitum nagarum, Aconitum napellus, Aconitum naviculare, Aconitum ouvrardianum, Aconitum paniculigerum, Aconitum pendulum, Aconitum polyschistum, Aconitum pomeense, Aconitum pterocaule, Aconitum racemulosum, Aconitum richardsonianum, Aconitum rotundifolium, Aconitum scaposum, Aconitum sczukinii, Aconitum sessiliflorum, Aconitum sinomantanum Nakai, Aconitum ...
CISDOC - Aconitine
ILO: International Labour Organization - The International Labour Organization is the UN specialized agency which seeks the promotion of social justice and internationally recognized human and labour rights
Difference between revisions of Aconitum toxicity - WikEM
Aconitum spp is a genus of over 250 flowering plants including Monkshood, Wolfs bane, Aconite, Leopards bane, mousebane, blue rocket, and queen of poisons. In the United States, most poisonous flower ingestions are accidental ingestions by children and account for roughly 2% of all toxic exposures; aconitum is not a commonly ingested flower in the United States, though is responsible for significant morbidity and mortality worldwide. Traditionally, most cases of adult ingestion of toxic flowers that lead to significant symptoms are suicidal attempts. A recent increase in aconitum poisoning has been reported secondary to an increase in available herbal medications utilizing the plant. All parts of Aconitum are toxic, with the roots being most toxic. Toxicity is due to Aconite alkaloids bind to open voltage-gated sodium channels, producing a hyperpolarized state, with permanent activation of the channels. Most herbal preparations undergo decoction process where plant is boiled to hydrolize ...
Headspace-solid-phase microextraction gas chromatography method to quantify <i>Thymus vulgaris</i> essential oil in polymeric...
Background: Thymus vulgaris essential oil (Tv-EO) is known to have antibacterial, antifungal, and antioxidant activities. Encapsulation of Tv-EO in polymeric nanoparticles (NPs) can prevent volatilization of its components and can provide protection against external agents. Under these circumstances, it is crucial to assure the presence and quantity of the Tv-EO components (γ-terpinene, thymol, and carvacrol) in the NPs. Objective: To determine the chemical composition and physicochemical characterization of Tv-EO as well as develop and validate a HSPM-gas chromatography (GC) method for the analysis of Tv-EO components encapsulated in NPs. Materials and Methods: Tv-EO was characterized by physicochemical analysis for relative density, refractive index, and optical rotation and analyzed by GC flame ionization detector and GC-mass spectrometry. The headspace-solid-phase microextraction-gas chromatography (HS-SPME-CG) validation was assessed, Tv-EO-NPs were prepared by nanoprecipitation, and its ...
During protracted myocardial ischemia, ATP depletion promotes Na+ accumulation in sympathetic terminals and prevents vesicular storage of norepinephrine (NE). This forces the reversal of the neuronal uptake1 transporter, and NE is massively released (carrier-mediated release). We had shown that histamine H3 receptors (H3Rs) modulate ischemic NE release in animals. We have now used a human model of protracted myocardial ischemia to investigate whether H3Rs may control carrier-mediated NE release. Surgical specimens of human atrium were incubated in anoxic conditions. NE release increased ∼7-fold within 70 min of anoxia. This release was carrier mediated because it was Ca++ independent and inhibited by the uptake1inhibitor desipramine. Furthermore, the Na+/H+exchanger (NHE) inhibitors ethyl-isopropyl-amiloride and HOE 642, and the Na+ channel blocker tetrodotoxin inhibited NE release, whereas the Na+ channel activator aconitine potentiated it. The selective H3R agonist imetit decreased NE ...
Doctors of BC Medical Museum : 993.241.1: Wallet, Medicine
Brown leather wallet holding nine vials of medicinal tablets. Each vial has cork stopper and a printed label stating name and address of manufacturer and the contents which include strychnine Gm. 0.001, aconitine Gm. 0.0005, calomel Gm. 0.01, morphine sulphate Gm. 0.005, hyoscyamine Gm. 0.00025, digitalin Gm. 0.001, glonoin Gm. 0.00025, anti-constpation formula and anodyne formula for infants. Name and address of manufacturer is printed in gold lettering on interior surface of lid flap.. ...
Aconitum Napellus 200CK | Single Remedies Boiron
Boiron Aconitum Napellus Helps Relieve Sudden Onset Fevers Accompanied by Dry SkinBoirons Aconitum Napellus 200CK, derived from wolfs bane, is formulated to help relieve a suddenly onset fever that coincides...
Aconitic synonyms, Aconitic antonyms - FreeThesaurus.com
Synonyms for Aconitic in Free Thesaurus. Antonyms for Aconitic. 11 words related to aconite: Aconitum, genus Aconitum, Aconitum napellus, helmet flower, monkshood, helmetflower, Aconitum lycoctonum, wolfbane, wolfs bane.... What are synonyms for Aconitic?
Aconitum hemsleyanum var. lasianthum in Flora of China @ efloras.org
106h. Aconitum hemsleyanum var. lasianthum W. T. Wang & L. Q. Li, Acta Phytotax. Sin. 25: 29. 1987. 毛萼瓜叶乌头 mao e gua ye wu tou Leaves cordate at base, distal ones without bulbils. Bracteoles and sepals pubescent on both surfaces. Upper sepal with indistinct abaxial hairs. Petals glabrous; spur more than 1.5 mm. Persistent style ca. 2.5 mm.. * Scrub; 3200--3300 m. W Sichuan (Muli Zang Zu Zizhixian).. ...
Aconitum anthora (Yellow monkshood) | Plant Finder | GreenPlantSwap
Aconitum anthora (Yellow monkshood). This species is an upright perennial. The leaves are rounded, deeply lobed and dark green. The flowers are produced in mid and late summer; racemes of pale yellow blooms.
Food 4 Less - Ollois Lactose Free Aconitum Napellus, 80 Pellets
Shop for Ollois Lactose Free Aconitum Napellus at Food 4 Less. Find quality products to add to your Shopping List or order online for Delivery or Pickup.
Aconitum delphiniifolium image
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Aconitum delphiniifolium image
ATIVISA - Aconitum heterophyllum
description - heterophyllum- Roots biennial, paired, tuberous; whitish or grey. Stem erect, simple or branched, from 15-20 cm high. glabrous below, finely crispo-pubescent in the upper par
Aconitum Napellus 6C | Single Remedies Boiron
FeverUses:Main Indication: High fever of sudden onset with dry skinCommon Name: MonkshoodWarnings:Stop use and ask a doctor if symptoms persist for more than 3 days or worsen.If pregnant or breast-feeding,...
The letters HPUS indicate that this ingredient is officially included in the Homeopathic Pharmacopœia of the United States.. ...
Helsana ch trails - Gratis kreditkarten österreich
Helsana ch trails. Concourslimo com. Bahnhofstrasse 4 ch 8810 horgen zürich. Winter seilpark interlaken. Aconitum napellus 15 ch avis. Baskethouse camp ch. Tutti ch kleider. Ch koordinaten umrechnen excel. Www okpunktstrich ch cards visa
MLA D-Tipper Pipette,120uL | Pipettes.com
MLA D-Tipper Pipette,120uL (Silver) Available in over 30 fixed volumes, from 5µL to 1000µL, the MLA D-Tipper is ideal for laboratories conducting repetitive.
Aconitum | Article about Aconitum by The Free Dictionary
Looking for Aconitum? Find out information about Aconitum. or any of several species of the genus Aconitum of the family Ranunculaceae , hardy perennial plants of the north temperate zone, growing wild or cultivated... Explanation of Aconitum
An Honest Drug: How To Grow Your Own Poison Garden
Aconitum napellus (Aconitum possibly from the greek for cone, napellus turnip) is known as the queen of the poisons, with the toxins aconite and aconitine present throughout the plant - the effects of which, which, in an interesting twist of poison counteracting poison, can be treated with atropine from Deadly Nightshade. Monkshood was often used as poison on arrows in Ancient Rome and China, and it is a close relative of the equally poisonous Aconitum Lycotonum, or Wolfsbane (so named for its ability to kill wolves). Death occurs within several hours of poisoning, with vomiting and nausea being early symptoms before death usually occurs by arrythmias. Despite their highly toxic nature, monkshood is popular as a garden plant, and if I have learned nothing else from this post its that the sanity of horticulturalist should probably be questioned ...
ACONITINUM. - THE ENCYCLOPEDIA OF PURE MATERIA MEDICA By TIMOTHY F. ALLEN, A.M., M.D.
Presented by M di-T. ACONITINUM.. Aconitine (C27 H40 NO10) is obtained from the roots and stems of Aconitum napellus, L.. This must not be confounded with Morsons (English) Aconitine (same as Nepalin of Fl ckiger, or Napellin of Wigger, or Pseudo-aconitine of Huebschmann), which is obtained from Aconitum ferox.. Authorities. 1, Schroff; t, Toxicological, from Bird an others.. MIND. ► Intellect most perfect, and even vivid, [t]. ► Thought slow; long thinking impossible; all attention disturbed, . ► Loss of sense, .. HEAD. ► Vertigo, . ► Confusion of head very great, . ► Headache, [t]. ► Pain in head and face more intense after the slightest mental exertion, .. EYES. ► Pupil dilated (both from internal and local use), [t]. ► Dimness of vision, [t].. EARS. ► Sense of pressure in ears, . [10.] ► Roaring in ears, .. FACE. ► A peculiar drawing, pressive sensation in the cheeks on upper jaw, the forehead (region of nervus trigeminus), increase in ...
Aconitum | Find Me A Cure
Species: Aconitum kusnezoffii. Common Name: Bei Wu Tou. Habitat: Aconitum kusnezoffii is native to E. Asia - N. China, N. Japan in Kamtschatka, Korea and Siberia. It grows on grassy slopes, grasslands, forests, forest margins, by streams at elevations of 2200 - 2400 metres.. Description:. Aconitum kusnezoffii is a perennial plant growing to 1.5 m (5ft). usually branched, glabrous, with leaves equally arranged along stem.Root stocks are conical or carrot-shaped, 2.5-5 cm, 7-12 mm in diam. Proximal cauline leaves withered at anthesis, middle ones shortly to long petiolate; petiole 3-11 cm, glabrous; leaf blade pentagonal, 9-16 × 10-20 cm, papery or subleathery, abaxially glabrous, adaxially sparsely retrorse pubescent, base cordate, 3-sect; central segment rhombic, apex acuminate, subpinnately divided or lobed; lateral segments obliquely flabellate, unequally 2-parted. Inflorescence terminal, 9-22-flowered; rachis and pedicels glabrous; proximal bracts 3-fid, others oblong or linear. Proximal ...
Research Interests for Edward D. Levin
1-Naphthylamine, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, 3,4-Dihydroxyphenylacetic Acid, Abnormalities, Drug-Induced, Acetylcholine, Acetylcholinesterase, Aconitine, Acoustic Stimulation, Actins, Acute Disease, Acyltransferases, Adaptation, Physiological, Adenylate Cyclase, Adiponectin, Adipose Tissue, Administration, Cutaneous, Administration, Oral, Adolescent, Adrenergic alpha-2 Receptor Antagonists, Adrenergic alpha-Antagonists, Adult, Aerosols, Affect, Age Factors, Age of Onset, Aged, Aged, 80 and over, Aging, Air Pollutants, Alcohol Deterrents, Alcohol Drinking, Alcoholism, Alkaloids, Allosteric Regulation, alpha-Methyltyrosine, Alzheimer Disease, Amino Acids, Amino Acids, Branched-Chain, Amphetamine, Amygdala, Anabasine, Anal Canal, Analgesics, Analysis of Variance, Animals, Animals, Newborn, Animals, Suckling, Anthelmintics, Anti-Anxiety Agents, Anti-HIV Agents, Anticonvulsants, Antidepressive Agents, Antineoplastic Agents, Hormonal, Antioxidants, Antipsychotic Agents, ...
Aconitum columbianum in Flora of North America @ efloras.org
5. Aconitum columbianum Nuttall in J. Torrey & A. Gray, Fl. N. Amer. 1: 34. 1838. Roots tuberous, tuber distally not obviously bulblike, to 60 × 15 mm, parent tuber producing 1 (rarely 2) daughter tubers with connecting rhizome very short, i.e., tubers ±contiguous. Stems erect and stout to twining and reclining, 2-30 dm. Cauline leaves: blade deeply 3-5(-7)-divided, usually with more than 2 mm leaf tissue between deepest sinus and base of blade, 5-15 cm wide, segment margins variously cleft and toothed. Inflorescences open racemes or panicles. Flowers commonly blue, sometimes white, cream colored, or blue tinged at sepal margins, 18-50 mm from tips of pendent sepals to top of hood; pendent sepals 6-16 mm; hood conic-hemispheric, hemispheric, or crescent-shaped, 11-34mm from receptacle to top of hood, 6-26 mm wide from receptacle to beak apex.. Subspecies 2 (2 in the flora): moist areas, primarily in w North America, sporadic in e U.S.. Available information suggests that Aconitum columbianum ...
Monkshood, Perennials, Aconitum - American Meadows
Aconitum, Monkshood available now at American Meadows. We provide creative gardeners with Aconitum, Monkshood and the highest quality perennials for the confidence they need to succeed. Place your order today and we guarantee 100% satisfaction. American Meadows, satisfying gardeners since 1981
Aconitum napellus ( Aconite ) | Backyard Gardener
This poisonous perennial graces many flower borders because of the beautiful, hooded, deep blue flowers borne on spikes in mid to late summer. Foliage is m
To the Editor -. We have read with great interest the paper by Leung et al. published in European Respiratory Journal , the correspondence by Russo et al.  and also the subsequent comment by the first group . Both research teams are reporting increased ACE-2 expression in airways of current smokers and those with COPD with important implications for COVID-19 patients. Since ACE-2 has been shown to be the main receptor utilised by SARS-CoV-2 to enter the host cells , the authors conclude that nicotine is a risk factor for COVID-19 pandemic. Russo et al.  have shown that nicotine up-regulates ACE-2 through alpha7 nAChRs which are present in neuronal and non-neuronal cells. Leung et al.  provided further evidence in support of this hypothesis and propose the repurposing of alpha7-nAChR antagonists for the pandemic (e.g. methyllycaconitine, alpa-conotoxin), expecting that such treatment will alter ACE-2 expression and prevent SARS-CoV-2 entry.. While this hypothesis is based on ...
AE Succinimide, an Analogue... - Researchers - ANU
Qudah, T, Quek, G, Indurthi, D et al 2020, AE Succinimide, an Analogue of Methyllycaconitine, When Bound Generates a Nonconducting Conformation of the α4β2 Nicotinic Acetylcholine Receptor, A C S Chemical Neuroscience, vol. 11, no. 3, pp. 344-355. ...
MLA Vulcan CBD20-15 Electric Pallet Mover
After over 25 years in Heavy Lift Trucks MLA supplies the reliable MLA Vulcan product to Heavy Lift Truck customers around Australia. Contact us today!
Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: importance of the 2-...
Methyllycaconitine (MLA, 1) is a novel, potent probe for mammalian and insect nicotinic acetylcholine receptors (nAChR) and displays remarkable selectivity toward neuronal [125I]-alpha-bungarotoxin (alpha BgTX) binding sites that correspond to alpha 7-type nAChR in mammalian brain. We have shown that, among a number of selected norditerpenoid alkaloids, elatine (2) and nudicauline (3) are equipotent with, or better than, MLA (1) in binding to brain [125I]-alpha BgTX binding sites, with IC50 values of 6.1, 1.7, and 7.6 nM, respectively. The 2-((S)-methylsuccinimido)benzoyl moiety of these ligands is crucial for high-affinity binding, whereas structural modifications to the norditerpenoid core of the ligand can be tolerated without loss of activity or selectivity. In addition to MLA (1), elatine (2), and nudicauline (3), we have examined lycoctonine (4), inuline (6), lappaconitine (7), N-desacetyllappaconitine (8), delsoline (10), delcorine (11), deltaline (12), condelphine (13), and karacoline (14). This
An HPLC assay for the norditerpenoid alkaloid methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist. -...
The extremely potent and selective nicotinic acetylcholine receptor antagonist methyllycaconitine, MLA, and related norditerpene alkaloids are finding increasing use as neurochemical probes and as targets for structure-activity relationship studies. In this work, an assay procedure for MLA which utilises ion suppression reverse-phase HPLC with UV absorbance detection at 270 nm is described. The method detected 280 ng MLA on column.
Aconitum - Wikipedia
Aconite has been understood as a poison from ancient times, and is frequently represented as such in fiction. In Greek mythology, the goddess Hecate is said to have invented aconite, which Athena used to transform Arachne into a spider. Also, Medea attempted to poison Theseus with a cup of wine poisoned with wolfs bane. The kyōgen (traditional Japanese comedy) play Busu (附子, Dried aconite root), which is well-known and frequently taught in Japan, is centered on dried aconite root used for traditional Chinese medicine. Taken from Shasekishu, a 13th-century anthology collected by Mujū, the story describes servants who decide that the dried aconite root is really sugar, and suffer unpleasant though nonlethal symptoms after eating it. Shakespeare, in Henry IV Part II Act 4 Scene 4 refers to aconite, alongside rash gunpowder, working as strongly as the venom of suggestion to break up close relationships. In BBC drama Shakespeare and Hatherway, series 2, episode 9, a ...
Aconitum in Slovakia | Genus Aconitum L. (Ranunculaceae) in Slovakia
The genus Aconitum in the flora of Slovakia is represented by subgenera Aconitum, Lycoctonum and Anthora. Among them the subgenus Aconitum is the richest and includes sections Aconitum and Cammarum DC., as well as nothosection Acomarum Starmühl. (sect. Aconitum × sect. Cammarm). It includes next taxa: 1) A. firmum Rchb. (subsp. firmum,subsp. moravicum Skalický, as well as it should includes contraversive subsp. maninense (Skalický) Starmühl. in Starmühl. & Mitka and nsubsp. paxii Starmühl. in Starmühl. & Mitka); 2) A. ×cammarum L. em. Fries; 3) A. variegatum L. subsp. variegatum; 4) A. lasiocarpum (Rchb.) Gáyer (subsp. lasiocarpum and subsp. kotulae (Pawł.) Starmühl. & Mitka); 5) A. degenii Gáyer subsp. degenii.. The second subgenus Lycoctonum (DC.) Peterm. is represented by: 1) A. moldavicum Hacq. (subsp. moldavicum, subsp. hosteanum (Schur) Graebn. & P. Graebn., subsp. simonkaianum (Gáyer) Starmühl.); 2) A. lycoctonum L. em. Koelle subsp. vulparia (Rchb.) Nyman; 3) controversive ...
Weleda aconite 30c - The Natural Shop
Aconite (Aconitum Napellus) is a natural homeopathic remedy.In homeopathy, aconite is used for fear, anxiety, and restlessness, fever symptoms from exposure to dry, cold weather or very hot weather; tingling, coldness, and numbness; influenza or colds with congestion; and headaches.
Approved Drugstore: Propecia horror stories purchase online!
Propecia horror stories - Consult your doctor if you are unable to assume caregiving role of antidysrhythmics pharmacologic blockade sodium potassium calcium class channels channels sodium channel openers aconitine andromedotoxin ciguatoxin veratridine restores the sinus node is regulated by controlling its absorption from the family that promotes the development of a serious illness childbirth stopping the oral bioavailability greater than 80 years of age reported annually to us poison centersmon name botanical name african violet willow species elderberry sanguinaria, bloodroot umbrella tree black mustard cabbage cactus caladium crown ower tea, green tea renal, carcinogenic neurologic cardiac cardiac, neurologic oxytocic, cardiovascular gastrointestinal hepatic. If your symptoms need urgent assessment in hospital. Studies in several organs.
Alkaloids, Ethers - Chemical Safety, Models, Suppliers, Regulation, and Patents
Methyllycaconitine (MLA) is a diterpenoid alkaloid found in many species of Delphinium (larkspurs). In common with many other diterpenoid alkaloids, it is toxic to animals, although the acute toxicity varies with species. Early research was focused on identifying, and characterizing the properties of methyllycaconitine as one of the principal toxins in larkspurs responsible for livestock poisoning in the mountain rangelands of North America ...
Aconitum Violaceum | Find Me A Cure
Botanical Name : Aconitum violaceum Family : Ranunculaceae Genus : Aconitum Tibetan Common Name:: bdud rtsi lo ma, bong nga nag po (Amrita leaves, black
Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety
We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivative
Fired Earth Aconite Yellow Matt Emulsion Paint 2.5L | Departments | DIY at B&Q
Fired Earth Aconite Yellow Matt Emulsion Paint 2.5L - B&Q for all your home and garden supplies and advice on all the latest DIY trends
The Yellow of Winter Aconite Warms Gardeners Heart - Even Though the Temperatures Remain Cold | BYGL
Gardeners are always looking for signs of spring. Although the calendar tells us it is officially spring, Mother-Nature can sometimes send mixed messages.
Death from Aconite: Inquest | The BMJ
Thank you for your interest in spreading the word about The BMJ.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Aconitum Barkers Variety | Knoll Gardens | Ornamental Grasses and Flowering Perennials
These flowering perennials are Deciduous: Cut back stems close to ground level from late February through to the end of March. Cut stems can be left on border as natural mulch or composted.. ...
ACONITUM NAPELLUS (Monkshood) - Homœopathy The Safer and Superior Medicine
Homoeopathy is all about finding the most similar remedy, and we are here to introduce everybody to the complex science and essential concepts of complementary health practice through homeopathy.
UC/JEPS: Jepson Manual treatment for ACONITUM columbianum
Flower bilateral; sepals 5, petal-like, upper 1 , others, hooded, generally enclosing upper 2 petals and stamens, tip generally rounded to beaked; petals 2 5, upper 2 clawed, blades generally inflated, tip spurred, lower 3 ,, sepals, scale-like, or 0; pistils generally ...
18-O-2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoyllycoctonine Summary Report | CureHunter
18-O-2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoyllycoctonine: alkaloid from the roots of Aconitum pseudo-laeve var. erectum; structure in first source
Classification | USDA PLANTS
Classification for Kingdom Plantae Down to Species Aconitum ferox Wall. ex Ser. Click on names to expand them, and on P for PLANTS profiles ...
3 Ways to Cite an Article in MLA Style - wikiHow
How to Cite an Article in MLA Style. Citations let your readers know exactly where to find the sources youve used for an academic paper. If youre writing a paper for a literature or humanities class, chances are youll be using the MLA...
B.C. Green Party MLA changes position on controversial wolf cull - The Globe and Mail
The MLA was initially critical of the action, but now says South Selkirk caribou herd will be wiped out if province doesnt help
Exclusive Interview: जानिए Pakistan से आए Ex MLA Baldev Kumar पर Dharamsot को क्यों है शक video - id 361b97987c32cf - Veblr
Exclusive Interview: जानिए Pakistan से आए Ex MLA Baldev Kumar पर Dharamsot को क्यों है शक#DainikSavera, #punjabinews
Aconitine "Monkshood". AACC.org. Retrieved 9 November 2018. Rahman, A, et al, New Norditerpenoid Alkoids from Aconitum ... The Pharmacology of Pseudaconitine and Japaconitine considered in relation to that of Aconitine, 1901 Tsudaan Y., Marion L., ...
Li, Xiaodong; Gu, Liwei; Yang, Lan; Zhang, Dong; Shen, Jianying (2017). "Aconitine: A potential novel treatment for systemic ... Toxicity of pristane is alleviated by aconitine. "pristane - Compound Summary". PubChem Compound. USA: National Center for ...
Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Poisoning may also occur following picking the leaves without wearing gloves; the aconitine toxin is absorbed easily through ... Treatment is similar to poisoning caused by oral ingestion. Aconitine is a potent neurotoxin that opens ... 19th-century illustration Model, Botanical Museum Greifswald Aconitum napellus - MHNT Aconitine: Raw Fu Zi, 0.004%; prepared Fu ...
Aconitine is a potent neurotoxin and cardiotoxin that causes persistent depolarization of neuronal sodium channels in ... Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Successful use of charcoal hemoperfusion has been claimed in patients with severe aconitine poisoning. Mild toxicity (headache ... Monkshood and other members of the genus Aconitum contain substantial amounts of the highly toxic aconitine and related ...
Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Poisoning may also occur following picking the leaves without wearing gloves; the aconitine toxin is absorbed easily through ... Treatment is similar to poisoning caused by oral ingestion. Aconitine is a potent neurotoxin that opens ... causing arrhythmia and hypotension if not processed to degrade ester-type alkaloids like aconitine. Caffeoyl derivatives from ...
Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Poisoning may also occur following picking the leaves without wearing gloves; the aconitine toxin is absorbed easily through ... The plant's chief toxic component, aconitine, is a potent neurotoxin that opens tetrodotoxin sensitive sodium channels. It ... Aconites have been used more recently in murder plots; they contain the chemical alkaloids aconitine, mesaconitine, ...
Deaths in July 2004
Andre Noble, 25, Canadian television and film actor, aconitine poisoning. Adolph Winkler Goodman, 89, American mathematician. ...
Other poisons in his possession included atropine, aconitine and digitalis. His lodgings were covered in swastikas and pictures ...
List of traditional Chinese medicines
... the highly toxic alkaloid aconitine. Aconitine is easily absorbed through the skin, eyes and through the lining of the nose; ... The Chinese also used aconitine both for hunting and for warfare. Birthworts (family Aristolochiaceae) are often used to treat ...
Murder of Lakhvinder Cheema
Victims of aconitine poisoning suffer severe vomiting, and often become paralysed. Their organs stop working and they die from ... The case was also unusual, as the last prosecution for murder using aconitine was that of George Henry Lamson in 1882.[citation ...
... is poisonous due to the presence of alkaloids like aconitine. Currently 2 subspecies are accepted: Aconitum ...
... is poisonous due to the presence of alkaloids like aconitine. The Plant List (KEW): Aconitum tauricum (2018- ...
History of general anesthesia
... aconitine and angelicotoxin. When consumed in sufficient quantity, tsūsensan produces a state of general anesthesia and ...
Philipp Lorenz Geiger
With Ludwig Hesse, he isolated the alkaloids atropine, aconitine, colchicine and hyoscyamine. In 1831 he was the first to ...
The active ingredients in tsūsensan were scopolamine, hyoscyamine, atropine, aconitine and angelicotoxin. When consumed in ...
... is poisonous due to the presence of alkaloids like aconitine. Currently 2 subspecies are accepted: Aconitum ...
Median lethal dose
Wolfgang Bücherl and Eleanor Buckley "Aconitine - National Library of Medicine HSDB Database". toxnet.nlm.nih.gov. Blayney MB ( ...
... batrachotoxin and aconitine. Experiments utilizing squid axonal membranes indicate that sodium channel binding likely occurs on ...
South Korea E. cilicica E. longistipitata E. pinnatifida, Mount Ibuki, Japan Aconitum Aconitine Schipcz, O. in Fl. U.S.S.R.,7 ...
Aconitine poisoning, regardless of the method of administration, manifests itself in the form of itching and tingling in ... The action is due to alkaloids, mainly aconitine, which is one of the most powerful plant poisons. When applied to the skin, it ... primarily aconitine), but their concentration depends on the phase of vegetation. Spring shoots before flowering are the ...
In medieval Europe, the toxic entheogen Aconitine was believed to prevent werewolves from undergoing their dire transformations ...
Compounds related to aconitine are widely studied for their properties in biological systems and these have been reviewed. For ... Aconitine (Articles without InChI source, Articles without EBI source, Articles without KEGG source, Articles without UNII ... which is the same as in aconitine and this is reflected in its preferred IUPAC name. Gigactonine was reported in 1978 after its ...
Compounds related to aconitine are widely studied for their properties in biological systems and these have been reviewed. For ... Aconitine (Articles with short description, Short description is different from Wikidata, Chemical articles with multiple ... polycyclic ring system containing nineteen carbon atoms and one nitrogen atom in these compounds is the same as in aconitine ...
Extracts from plants containing toxic alkaloids, such as aconitine and tubocurarine, were used since antiquity for poisoning ...
4.50 from Paddington
Harold takes them; they are poisoned with aconitine, and he dies whilst being watched taking the tablets by Lady Alice, his ...
... including aconitine and pseudaconitine. The use of Aconitum as an additive in beer-brewing is therefore a practice fraught with ...
All parts of the plant, with the highest concentration being in the roots and seeds, contain aconitine, which is a potent nerve ...
"Pots with wicks of flax or cotton were used, containing a combination of sulfur, saltpeter (potassium nitrate), aconitine, oil ...
George Henry Lamson
He had poisoned his victim with aconitine in the cake, a substance which Lamson had learned about from Professor Robert ... Christison had taught that aconitine was undetectable, but forensic science had improved since Lamson's student days and the ... from a batch that were later tested and found to contain the poison aconitine, as recorded in the case history at Old Bailey ... Alarmed by press reports of Percy's death and confident that the aconitine would be undetectable, Lamson voluntarily returned ...
Dr George Henry Lamson, who poisoned Percy Johns (his crippled brother-in-law) with aconitine at Wimbledon so his wife could ...
aconitine | Hearken to Avalon
Berberine: MedlinePlus Supplements
Aconitine; Arrhythmia MeSH Terms. Academic Medical Centers. Aconitine*. Aconitum. Alkaloids. Arrhythmias, Cardiac. Atropine. ... Aconitine and its related alkaloids can cause toxic effects and even fatal poisoning. These cases point to the need for strict ... Aconitine and its related alkaloids are known cardiotoxins with no therapeutic role in modern western medicine. We have studied ... However, one case of acute aconitine poisoning had been dead of cardiac arrest due to ventricular fibrillation. CONCLUSION. ...
Aconitine Preferred Term Term UI T000456. Date01/01/1999. LexicalTag NON. ThesaurusID ... Aconitine Preferred Concept UI. M0000236. Registry Number. X8YN71D5WC. Related Numbers. 302-27-2. Scope Note. A C19 ... Aconitine. Tree Number(s). D02.455.849.291.184.037. D03.132.301.030. Unique ID. D000157. RDF Unique Identifier. http://id.nlm. ...
Csupor D - Search Results - PubMed
US8883840B2 - Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents - Google Patents
poisonous plant | Search Online Etymology Dictionary
ExecutedToday.com » 1772: Johann Friedrich Struensee, the doctor who ran Denmark
Browse - Central Criminal Court
Cross-examined. I have never seen a case of death from aconitine unless. the present be one-after taking of a dose of aconitine ... 16-I cannot give the amount of aconitine in No. 19-I tasted it-there was aconitine in it, a trifle more than in No. 17, but ... use of aconitine-I do not know that aconitine appears in the British Pharmacopœia-I do not know a book by Fleming on aconitine- ... Bright did-I have never kept aconitine or aconitia-I have never dealt in aconitine. ...
Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos Patents and Patent Applications (Class 514/279) ...
Improvement of decocting method for Kampo medicines using a microwave oven to extend its applications in clinical practice
16] reported that the LD50 values of aconitine in mice were 1.8 mg/kg p.o., 0.308 mg/kg i.p. and 0.12 mg/kg i.v., those of ... Effects of long-term administrations of aconitine on electrocardiogram and tissue concentrations of aconitine and its ... Huang, Q. A., Zhang Y. M., He Y., Lu, J. and Lin, R. C. (2007) Studies on hydrolysis of aconitine. China Journal of Chinese ... When processing or decocting, the ester bonds on C-8 of aconitine alkaloids are hydrolyzed and the acetyl groups are lost, ...
Proteomes | Free Full-Text | Comparison of Sample Preparation Methods for Shotgun Proteomic Studies in Aquaculture Species
CCCC 1956, Volume 21, Issue 6, Abstracts pp. 1614-1623 | Collection of Czechoslovak Chemical Communications
Effect of aconitine on the metabolism of animal tissues in vitro II. Changes in the metabolism of brain, liver and kidney ... This article is part of serial Effect of aconitine on the metabolism of animal tissues. ... tissue in the presence of aconitine, potassium ions, and 2,4-dinitrophenol. Z. Beránková and F. Šorm ...
Advanced search - Recalls, advisories and safety alerts - Canada.ca
Ecological impacts of invasive alien species on bees | Apidologie
The Local Anesthetic and Pain Relief Activity of Alkaloids | IntechOpen
Literature also refers that some alkaloids including aconitine, atropine, colchicine, coniine, ephedrine, ergotamine, mescaline ... aconitine, and tubocurarine have been used for toxic purposes in ancient time. The poisonous alkaloids were prepared from ... tends to produce pharmaceuticals on the basis of natural alkaloids and alkaloids with modified structure such as aconitine, ...
Activators | Alomone Labs
Aconitine - Preferred Concept UI. M0000236. Scope note. A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; ... Aconitine Entry term(s). Acetylbenzoyl aconine Acetylbenzoyl-aconine Acetylbenzoylaconine Aconitane-3,8,13,14,15-pentol, 20- ... aconitina. Entry term(s). (1-alfa,3-alfa,6-alfa,14-alfa,15-alfa,16-beta)-20-etil-1,6,16-trimetoxi-4-(metoximetil)-aconitano-3,8 ... Aconitine Entry term(s):. Acetylbenzoyl aconine. Acetylbenzoyl-aconine. Acetylbenzoylaconine. Aconitane-3,8,13,14,15-pentol, 20 ...
Code System Concept
Dr. Wheeler Opinion Paper on Herbal Tea Poisons Two San Franciscans - CSOMA
Danggui Sini decoction treatment of refractory allergic cutaneous vasculitis: A case report
IMSEAR at SEARO: Search
Poisonous Flowers and Toxic Plants to Avoid | Bouqs Blog
Pyrethrum: History of a Bio-Insecticide - Part 6 - ChemistryViews
Creekwalking | Inn on the Alameda
- Aconitine and its related alkaloids are known cardiotoxins with no therapeutic role in modern western medicine. (koreamed.org)
- Aconitine and its related alkaloids can cause toxic effects and even fatal poisoning. (koreamed.org)
- Semisynthesis and pharmacological investigation of lipo-alkaloids prepared from aconitine. (nih.gov)
- Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots. (nih.gov)
- Fu 1997 , Fu 2006 , Murayama 1991 , Murayama 1980 , Tai 1992 , Wang 2001 Other alkaloids may be produced by processing (eg, pyro-type aconitine alkaloids by heat Murayama 1991 or benzylaconines or aconines by hydrolysis). (questiontime.info)
- Aconitine and its congeners are considerably more toxic than aconine and related alkaloids. (questiontime.info)
- Aconitine-like alkaloids appear to target the CNS for their analgesic action, although they also display local anesthetic properties. (ncku.edu.tw)
- Our results suggest that "aconitine-like" alkaloids could be exploited as an additive for Jong-lasting cutaneous analgesia. (ncku.edu.tw)
- In less than 3 hours, this process removes most, if not all of the diterpene alkaloids (DDA), including the toxic alkaloid aconitine. (classicalpearls.eu)
- By comparison, conventional modern aconite processing uses hydrochloric acid, sulfuring agents, and other chemicals to both remove the skin and essentially "bleach" out the aconitine and other alkaloids. (classicalpearls.eu)
- East of other-type aconitine alkaloids, fillers or suppress boy one. (modellervefiyatlar.com)
- According to press release from the SFDPH the toxic alkaloid aconitine was discovered in the lab tests of both patients as well as the tea samples they provided. (csomaonline.org)
- The toxin, aconitine, comes from the restaurant on the evening of Sunday, Aug where can i get pentasa. (clemmlaw.com)
- similar to veratridine , aconitine, and batrachotoxin, they are known for poisoning and killing livestock. (iem-student.org)
- It contains a number of poisons called Aconitine, Mesaconitine, and Hypaconitine. (gardencue.com)
- Aconitine is highly toxic. (questiontime.info)
- BACKGROUND AND OBJECTIVES: The Oriental herbal materials known as aconitine have long been used in oriental traditional medicine for their analgesic and antiinflammatory effects. (koreamed.org)
- 3-Acetylaconitine (3AA) is an "aconitine-like" plant alkaloid that has been used as an analgesic agent for the treatment of chronic pain and rheumatoid arthritis in China. (ncku.edu.tw)
- The affected product is being recalled from the marketplace due to aconitine contamination. (canada.ca)
- MATERIALS AND METHOD: During a six-year interval from 1990 to 1996, 9 cases of accidental herb-induced aconitine intoxication were managed in Kyung Hee university medical center. (koreamed.org)
- Aconitine is an alkaloid derived from various species of Aconitum. (questiontime.info)
- The frequency of the order in cardinal symptoms of acute aconitine poisoning was nausea or vomiting, irritability, chest discomfort, dizziness, etc. (koreamed.org)
- The highly poisonous alkaloid in it, once isolated, was named aconitine (1826). (etymonline.com)
- All patients developed symptoms of aconitine toxicity within 4 hours of herb ingestion. (koreamed.org)
- Excessive amounts of these materials, which contain diterpene alkaloids particularly aconitine, can produce toxic effects and occasional fatalities. (heilpflanzen-welt.de)
- Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. (edu.hk)
- Studies of aconitine-type alkaloids in the Chinese herb Aconitum Carmichaeli were performed by HPLC/ESIMS/MS n and FTICR/ESIMS in positive ion mode. (edu.hk)
- The immediate effects of the toxic cocktail of diterpene alkaloids (e.g., aconitine) include reduced heart rate, burning, tickling, numbness and sensations of having fur or feathers. (ox.ac.uk)
Poison called ac1
- And that wickedness comes from the poison called aconitine. (naturespoisons.com)
- The highly poisonous alkaloid in it, once isolated, was named aconitine (1826). (etymonline.com)
- Monkshood, named for the hood-shaped, deep blue flowers, contains the alkaloid aconitine in all its parts and has been historically used to poison bait wolf traps (hence its nickname, wolfbane). (vaildaily.com)
- Aconitwn yields an alkaloid aconitina. (biologyboom.com)
- The Greek historian Diogenes Laërtius (3rd century CE), in his Lives and Opinions of Eminent Philosophers , notes the claim of Eumelus (an otherwise unknown historian) that Aristotle died after drinking a preparation of aconite (a genus of flowering plant containing the deadly poison aconitine, which has medicinal properties in tiny amounts). (britannica.com)
- Mesaconitine and aconitine are effective in decreasing the pain sensation elicited by acetic acid. (jfda-online.com)
- On day 29, aconitine was infused intravenously for induction of cardiac arrhythmia. (rcvmonline.com)
- Kimura investigated the cardiac effects of these compounds on murine right and left atria and the interaction of higenamine with aconitine on the rate of spontaneously beating right atria. (redcon1online.com)
- The active ingredients of scopolamine, hyoscyamine, atropine, aconitine and angelicotoxin serve as acetylcholine antagonists that can prove to be deadly. (medicalizationpodcast.com)
- Aconitine induced tachyarrhythmia in right atria was attenuated by quinidine , atropine and AF-DX 116, suggesting that aconitine activates sodium channels and muscarinic receptors. (redcon1online.com)
- In the https://www.vertikalrms.com/bdjj16ik compounds, hot, aconitine is warranted. (rogueimc.org)
- Aconitine is the most dangerous of these toxins. (usersquestions.com)
- I believe the aconitine was already in the capsule and the shaking was to make sure there was no chance of either Percy John or the headmaster noticing another substance in addition to the sugar. (naturespoisons.com)
- Substance used: aconitina. (bvsalud.org)
- Aconitine is present in every part of Monkshood, from its pretty flowers right down to its dirty roots. (naturespoisons.com)
- Perlman, R. and Guideri, G. Cardiovascular changes produced by the injection of aconitine at the area of the locus coeruleus in unanesthetized rats. (antoninragache.com)
- Historically, there have been several high profile murders involving aconitine. (naturespoisons.com)
- Aconitine is a secondary metabolite formed by the plant. (naturespoisons.com)
- When any part of the plant is ingested, the aconitine is absorbed through the gut and goes to work. (naturespoisons.com)
- They didn't say: "Oh, the berries from this plant are more poisonous than the berries from that plant over there because these berries contain aconitine and, as we all know, scientific studies show that aconitine disables nerves, lowers blood pressure, and can stop the heart. (unexplained-mysteries.com)
- The active ingredient of the plant is aconitine, which can be easily reduced to a white-yellow powder. (amarobsession.it)
- The abnormal focal activity theory also garnered some empirical evidence with the use of monophasic action potential recordings in response to altering environment conditions and pharmacological agents, [ 18 ] including a notable study on the focal application of aconitine that revitalized the argument for multiple centers of local activity in experimental fibrillation. (medscape.com)
- its action closely resembles that of aconitine. (henriettes-herb.com)
- One of those being its ability to increase heart rate, which is evident by work from Kimura et al on the positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria. (redcon1online.com)
- These results indicate that higenamine is a beta 1-adrenoceptor full agonist in murine atria and that the aconitine-induced tachyarrhythmia is augmented by the beta 1-adrenergic action of higenamine (3. (redcon1online.com)
- In the accompanying paper, the resistance to infections with HSV type 1 (HSV-1) and Candida albicans was improved in thermally injured mice treated with benzoylmesaconine (BEN), an aconitine-hydrolysate isolated from heated Aconiti tuber, or inoculated with splenic CD4 + T cells from BEN-treated mice (BEN T cells). (utmb.edu)
- 125 Honda Xrm Motorcycle Parts manufacturers - Update me on new products 1,027 125 Honda Xrm Motorcycle Parts results from 139 Manufacturers Verified Manufacturers Global Sources Payments Accepts Sample Orders Product Videos Sort by Relevancy Supplier Rank: Descending Date Product Posted Response Rate Response Time Mknis Honda xrm 125 parts manual gourd was snared agaze below the aconitine. (hedgefundgroup.org)
- He was taught that aconitine was undetectable, which was true at the time, but the field of toxicology is always advancing, and he was tried, found guilty, and hung. (naturespoisons.com)
- Aconitine poisoning following the ingestion of Chinese herbal medicines: a report of eight cases. (heilpflanzen-welt.de)