Chemicals and Drugs
Aconitic Acid
Aconitic Acid

A novel selection regime for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome. (1/23)

A novel selection scheme has been developed to isolate bloodstream forms of Trypanosoma brucei, which are defective in their ability to differentiate to the procyclic stage. Detailed characterization of one selected cell line (defective in differentiation clone 1 [DiD-1]) has demonstrated that these cells are indistinguishable from the wild-type population in terms of their morphology, cell cycle progression, and biochemical characteristics but are defective in their ability to initiate differentiation to the procyclic form. Although a small proportion of DiD-1 cells remain able to transform, deletion of the genes for glycophosphatidyl inositol-phospholipase C demonstrated that this enzyme was not responsible for this inefficient differentiation. However, the attenuated growth of the Delta-glycophosphatidyl inositol-phospholipase C DiD-1 cells in mice permitted the expression of stumpy characteristics in this previously monomorphic cell line, and concomitantly their ability to differentiate efficiently was restored. Our results indicate that monomorphic cells retain expression of a characteristic of the stumpy form essential for differentiation, and that this is reduced in the defective cells. This approach provides a new route to dissection of the cytological and molecular basis of life cycle progression in the African trypanosome.  (+info)

Unexpected anthracycline-mediated alterations in iron-regulatory protein-RNA-binding activity: the iron and copper complexes of anthracyclines decrease RNA-binding activity. (2/23)

Anthracyclines are effective antineoplastic agents. However, the interaction of these drugs with iron (Fe) is an important cause of myocardial toxicity, limiting their therapeutic use (J Lab Clin Med 122:245-251, 1993). To overcome this limitation, it is crucial to understand how anthracyclines interact with the Fe metabolism of myocardial and neoplastic cells. Iron-regulatory proteins (IRPs) play vital roles in regulating cellular Fe metabolism via their mRNA-binding activity. We showed that doxorubicin (DOX) and its analogs interfere with tumor and myocardial cell Fe metabolism by affecting the RNA-binding activity of IRPs. Unexpectedly, experiments with the free radical scavengers, catalase, superoxide dismutase, ebselen, and Mn(III) tetrakis (4-benzoic acid) porphyrin complex, suggested that the effects of DOX on IRP-RNA-binding activity were not due to anthracycline-mediated free radical production. In contrast to previous studies, we showed that the DOX metabolite, doxorubicinol, had no effect on IRP-RNA-binding activity. Rather, the anthracycline-Fe and -copper (Cu) complexes decreased IRP-RNA-binding activity, indicating that formation of anthracycline-metal complexes may affect cellular Fe metabolism. In addition, anthracyclines prevented the response of IRPs to the depletion of intracellular Fe by chelators. This information may be useful in designing novel therapeutic strategies against tumor cells by combining chelators and anthracyclines. Interestingly, the effect of DOX on primary cultures of cardiomyocytes was similar to that observed using neoplastic cells, and particularly notable was the decrease in IRP2-RNA-binding activity. Our results add significant new information regarding the effects of anthracyclines on Fe metabolism that may lead to the design of more effective treatments.  (+info)

Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei. (3/23)

Transmission of a protozoan parasite from a vertebrate to invertebrate host is accompanied by cellular differentiation. The signals from the environment that trigger the process are poorly understood. The model parasite Trypanosoma brucei proliferates in the mammalian bloodstream and in the tsetse fly. On ingestion by the tsetse, the trypanosome undergoes a rapid differentiation that is marked by replacement of the variant surface glycoprotein (VSG) coat with GPI-anchored EP and GPEET procyclins. Here we show that a cold shock of DeltaT > 15 degrees C is sufficient to reversibly induce high-level expression of the insect stage-specific EP gene in the mammalian bloodstream stages of T. brucei. The 3'-UTR of the EP mRNA is necessary and sufficient for the increased expression. During cold shock, EP protein accumulates in the endosomal compartment in the proliferating, slender, bloodstream stage, whereas the EP is present on the plasma membrane in the quiescent, stumpy, bloodstream stage. Thus, there is a novel developmentally regulated cell surface access control mechanism for a GPI-anchored protein. In addition to inducing EP expression, cold shock results in the acquisition of sensitivity to micromolar concentrations of cis-aconitate and citrate by stumpy but not slender bloodstream forms. The cis-aconitate and citrate commit stumpy bloodstream cells to differentiation to the procyclic stage along with rapid initial proliferation. We propose a hierarchical model of three events that regulate differentiation after transmission to the tsetse: sensing the temperature change, surface access of a putative receptor, and sensing of a chemical cue.  (+info)

The FAD-dependent tricarballylate dehydrogenase (TcuA) enzyme of Salmonella enterica converts tricarballylate into cis-aconitate. (4/23)

Tricarballylate is the causative agent of grass tetany, a ruminant disease characterized by acute magnesium deficiency. Tricarballylate toxicity has been attributed to its ability to chelate magnesium and to inhibit aconitase, a Krebs cycle enzyme. Neither the ruminant nor the normal rumen flora can catabolize tricarballylate to ameliorate its toxic effects. However, the gram-negative enterobacterium Salmonella enterica can use tricarballylate as a carbon and energy source, providing an opportunity to study the genes and enzymes required for tricarballylate catabolism. The tricarballylate utilization (tcu) genes are organized into two transcriptional units, i.e., tcuR and tcuABC. Here, we report the initial biochemical analysis of TcuA. TcuA catalyzed the oxidation of tricarballylate to cis-aconitate. The apparent K(m) of TcuA for tricarballylate was 3.8 +/- 0.4 mM, with a V(max) of 7.9 +/- 0.3 mM min(-1), turnover number (k(cat)) of 6.7 x 10(-2) s(-1), and a catalytic efficiency (k(cat)/K(m)) of 17.8 M(-1) s(-1). Optimal activity was measured at pH 7.5 and 30 degrees C. The enzyme was inactivated at 45 degrees C. One mole of FAD was present per mole of TcuA. We propose a role for TcuB as an electron shuttle protein responsible for oxidizing FADH(2) back to FAD in TcuA.  (+info)

The three-dimensional crystal structure of the PrpF protein of Shewanella oneidensis complexed with trans-aconitate: insights into its biological function. (5/23)

In bacteria, the dehydration of 2-methylcitrate to yield 2-methylaconitate in the 2-methylcitric acid cycle is catalyzed by a cofactor-less (PrpD) enzyme or by an aconitase-like (AcnD) enzyme. Bacteria that use AcnD also require the function of the PrpF protein, whose function was previously unknown. To gain insights into the function of PrpF, the three-dimensional crystal structure of the PrpF protein from the bacterium Shewanella oneidensis was solved at 2.0 A resolution. The protein fold of PrpF is strikingly similar to those of the non-PLP-dependent diaminopimelate epimerase from Haemophilus influenzae, a putative proline racemase from Brucella melitensis, and to a recently deposited structure of a hypothetical protein from Pseudomonas aeruginosa. Results from in vitro studies show that PrpF isomerizes trans-aconitate to cis-aconitate. It is proposed that PrpF catalysis of the cis-trans isomerization proceeds through a base-catalyzed proton abstraction coupled with a rotation about C2-C3 bond of 2-methylaconitate, and that residue Lys73 is critical for PrpF function. The newly identified function of PrpF as a non-PLP-dependent isomerase, together with the fact that PrpD-containing bacteria do not require PrpF, suggest that the isomer of 2-methylaconitate that serves as a substrate of aconitase must have the same stereochemistry as that synthesized by PrpD. From this, it follows that the 2-methylaconitate isomer generated by AcnD is not a substrate of aconitase, and that PrpF is required to generate the correct isomer. As a consequence, the isomerase activity of PrpF may now be viewed as an integral part of the 2-methylcitric acid cycle.  (+info)

A high-throughput method to measure NaCl and acid taste thresholds in mice. (6/23)

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A surface transporter family conveys the trypanosome differentiation signal. (7/23)

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Synthesis and properties of polycarboxylate-type green surfactants with S- or N-linkages. (8/23)

Polycarboxylate-type green surfactants with either sulfide- (S-) or imino- (N-) linkages were prepared in high yields by a single addition reaction of fatty mercaptan or fatty amine with unsaturated polycarboxylic acids such as fumaric, maleic, itaconic and aconitic acids. They exhibited surfactant properties and excellent biodegradabilities. Also, green surfactants with S-linkages showed better calcium ion sequestration abilities compared to the corresponding surfactant having an N-linkage. Among these surfactants, aconitic acid-derived polycarboxylate with an S-linkage exhibited calcium ion sequestration capacities similar to that of disodium 3-oxapentanedioate (ODA), a conventional calcium ion sequestrant on a molar basis of the surfactant.  (+info)

aconitic acid - Wiktionaryaconitic acid - Wiktionary
Two isomeric acids are formed by the distillation of malic acid, which are likewise isomeric with aconitic acid obtained by fusing citric acid, and of which one has been proved to be identical with the acid which occurs in Fumaria officinalis. ...
https://en.wiktionary.org/wiki/aconitic_acid
Arihant Innochem introduces US-based Colonial Chemicals green surfactant for sulphate-free personal care products | Business...Arihant Innochem introduces US-based Colonial Chemicals green surfactant for sulphate-free personal care products | Business...
Read more about Arihant Innochem introduces US-based Colonial Chemicals green surfactant for sulphate-free personal care products on Business Standard. Suga Nate 160NC surfactant, from Colonial Chemical, is derived from renewable feedstock sources, and provides many advantages in a broad range of home & personal care product applications
http://www.business-standard.com/article/b2b-connect/arihant-innochem-launches-green-surfactant-for-sulphate-free-personal-care-products-115061800360_1.html
tam - Trans-aconitate 2-methyltransferase - Escherichia coli (strain K12) - tam gene & proteintam - Trans-aconitate 2-methyltransferase - Escherichia coli (strain K12) - tam gene & protein
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis-aconitate, isocitrate, and citrate at lower velocities and affinities.
https://www.uniprot.org/uniprot/P76145
Krebs cycle step 2 - Proteopedia, life in 3DKrebs cycle step 2 - Proteopedia, life in 3D
Figure: Reaction of the isomerisation of citrate to isocitrate. In the second reaction of the Krebs cycle, the isomerisation of citrate to isocitrate takes place. As an intermediate, cis-aconitate is formed. Therefore, it is a two-step reaction sequence. In the first step, H2O is removed from the cireate molecule (see Figure). Thie dehydration ledas to the intermediate, cis-aconitate which is bound to the enzyme. In the second step, cis-aconitate is hydrated again. Therefore, the proton (from C2 to C3) and the OH group (from C3 to C2) swap places. A tretiary aclohol is transformed into a secondary alcohol.. This conversion is of utmost importance for the subsequent decarboxylation, because a tertiary alcohol (the citrate) can not be directly oxidized to a keto carboxylic acid.. ...
http://proteopedia.org/wiki/index.php/Krebs_cycle_step_2
Succinate As the Dominant Player in Krebs Cycle Bioenergetics
Majid Ali, M.D. Succinate Circa 2004 Table 1. The Frequency of Increased* Urinary Excretion of Metabolites of the Krebs Cycle in 236 Patients with Dysoxygenosis Citric acid Succinic acid Aconitic acid Fumaric acid 2-oxo-glutaric acid 196 40 26 1 0 * Increases beyond the laboratory range for the general population. Levels of acids measured in…
https://alihealing.org/2015/06/28/succinate-as-the-dominant-player-in-krebs-cycle-bioenergetics/
Molecular control of irreversible bistability during trypanosome developmental commitment<...
TY - JOUR. T1 - Molecular control of irreversible bistability during trypanosome developmental commitment. AU - Domingo-Sananes, Maria Rosa. AU - Szoor, Balazs. AU - Ferguson, Michael A. J.. AU - Urbaniak, Michael D.. AU - Matthews, Keith R.. PY - 2015/10/26. Y1 - 2015/10/26. N2 - The life cycle of Trypanosoma brucei involves developmental transitions that allow survival, proliferation, and transmission of these parasites. One of these, the differentiation of growth-arrested stumpy forms in the mammalian blood into insect-stage procyclic forms, can be induced synchronously in vitro with cis-aconitate. Here, we show that this transition is an irreversible bistable switch, and we map the point of commitment to differentiation after exposure to cis-aconitate. This irreversibility implies that positive feedback mechanisms operate to allow commitment (i.e., the establishment of memory of exposure to the differentiation signal). Using the reversible translational inhibitor cycloheximide, we show ...
https://www.research.ed.ac.uk/en/publications/molecular-control-of-irreversible-bistability-during-trypanosome-
Antimicrobial Resistance Differs Significantly Between Hospitals - Research database - University of GroningenAntimicrobial Resistance Differs Significantly Between Hospitals - Research database - University of Groningen
Materials/methods: In this study, bug/drug combinations were analysed of all bacterial blood culture isolates from patients of all 14 secondary and tertiary care hospitals in the Northern Netherlands detected in the last 15 years (between 2002 to 2016). Only first isolates were selected and included by using a novel selection algorithm, based on the M39-A4 guideline of CLSI, taking into account isolate-specific resistance of key antibiotics which were chosen based on the genus and Gram stain. Subsequently, we compared the resistance of blood culture isolates between hospitals using a full-region approach ...
https://www.rug.nl/research/portal/publications/antimicrobial-resistance-differs-significantly-between-hospitals
KEGG ENZYME: 5.3.3.7
cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. This isomerization could take place either in a direct cis-trans interconversion or by an allylic rearrangement; the enzyme has been shown to catalyse the latter change ...
http://www.genome.jp/dbget-bin/www_bget?ec:5.3.3.7
PRODUCTS WITH ORAL HEALTH BENEFITS - UCL BUSINESS PLCPRODUCTS WITH ORAL HEALTH BENEFITS - UCL BUSINESS PLC
The invention provides novel compositions for promoting oral health e.g. for ameliorating, controlling or reducing the risk of dental caries or periodontal disease such as gingivitis or periodontitis. The compositions are generally functional foods or oral preparations which comprises one or more extracts, for example particular low molecular weight extracts, of natural products (Shiitake mushroom, chicory and\or raspberry). Also provided are compositions utilising quinic acid; adenosine; inosine; trans-aconitic acid; oxalic acid; adenosine; cis-aconitic acid and succinic acid, or salts thereof, for promoting oral health.
http://www.sumobrain.com/patents/wipo/Products-with-oral-health-benefits/WO2012001347.html
Electron Nuclear Double Resonance (ENDOR) approach for studying radiation damage in DNA - EMR (Electron Magnetic Resonance)Electron Nuclear Double Resonance (ENDOR) approach for studying radiation damage in DNA - EMR (Electron Magnetic Resonance)
The ultimate ambition of this project is to perform an EMR study of radiation-induced radicals on DNA samples, comparably successful as for sucrose. This would provide the most direct way to determine the precise role of sugar radicals in radiation damage to DNA. Mainly because of the lack of DNA single crystals (DNA fibers are only partially oriented), literature studies have so far been restricted to EPR studies of polycrystalline or frozen solution DNA, with high risk of erroneous conclusions based only on isotropic parameters, as the UGent group demonstrated recently for trehalose . This could be avoided if information on the anisotropy of g and hyperfine tensors is collected for confrontation with DFT calculations. Therefore we are exploring the possibilities of powder ENDOR (and/or pulsed EPR), first on DNA-related materials and later in the project on DNA. It is known, but still remarkable that anisotropic information can be retrieved from powder materials exploiting the orientation ...
https://www.ugent.be/we/solidstatesciences/emr/en/research/runningproject2.htm
Browsing publications of the research group recombinant protein expression (RPEX) by Submit DateBrowsing publications of the research group recombinant protein expression (RPEX) by Submit Date
Abstract Background The filamentous fungus Aspergillus niger is well-known as a producer of primary metabolites and extracellular proteins. For example, glucoamylase is the most efficiently secreted protein of Aspergillus niger, thus the homologous glucoamylase (glaA) promoter as well as the glaA signal sequence are widely used for heterologous protein production. Xylose is known to strongly repress glaA expression while maltose is a potent inducer of glaA promoter controlled genes. For a more profound understanding of A. niger physiology, a comprehensive analysis of the intra- and extracellular proteome of Aspergillus niger AB1.13 growing on defined medium with xylose or maltose as carbon substrate was carried out using 2-D gel electrophoresis/Maldi-ToF and nano-HPLC MS/MS. Results The intracellular proteome of A. niger growing either on xylose or maltose in well-aerated controlled bioreactor cultures revealed striking similarities. In both cultures the most abundant intracellular protein was ...
https://repository.helmholtz-hzi.de/handle/10033/620777/browse?type=dateaccessioned
Sustainability: Trends in Polymers and Surfactants for Hair CareSustainability: Trends in Polymers and Surfactants for Hair Care
Market trends are driving the development of polymer and surfactant ingredients toward natural origins-in particular, plants. In this article, the authors review some of the recent trends in green surfactants and polymers for hair care. One interesting technology transfer trend is the use of hydrogen-bonded supramolecular networks to produce self-healing fixative films.
http://www.cosmeticsandtoiletries.com/formulating/function/surfactant/premium-Sustainability-Trends-in-Polymers-and-Surfactants-for-Hair-Care.html
PoultryWorld - Study identifies chickens with increased resistance to diseasePoultryWorld - Study identifies chickens with increased resistance to disease
Research funded by the U.S. Poultry & Egg Association studied the functional genomic and DNA microarray approach to identify key innate immunity genes as a novel selection method to identify chickens with increased resistance to disease.
http://www.poultryworld.net/Home/General/2007/9/Study-identifies-chickens-with-increased-resistance-to-disease-WP001760W/
Beef Cheeks - 1 lb. | US Wellness MeatsBeef Cheeks - 1 lb. | US Wellness Meats
Beef cheek meat is a thick muscle that offers a wonderful flavor to specialty dishes. When cooked slowly using moist heat, it will also become extremely tender. If you are a savvy food connoisseur you will find this novel selection a perfect addition to your recipes.
https://grasslandbeef.com/beef-cheeks
Citrus College - Registered Nursing-Associate Degree Nursing ProgramCitrus College - Registered Nursing-Associate Degree Nursing Program
Graduates of the Citrus College ADN Program will be prepared in three basic roles within the health care delivery system: provider of care, manager of care, and team member within the discipline of nursing. Graduates of the ADN program are eligible to take the National Council Licensure Examination for Registered Nurses (NCLEX-RN). Graduates who successfully pass the NCLEX-RN will be eligible for licensure to practice as a registered nurse in California. Only the Board of Registered Nursing may issue the Registered Nursing License. Citrus College and the Health Sciences Department are equally committed to assisting each and every student in achieving success. For this reason, specific procedures regarding enrollment and re-entry are in place to ensure that all students committed to their educational goals are given every opportunity to progress and complete the program. Program ...
http://www.citruscollege.edu/academics/programs/adn/Pages/default.aspx
DI49 2832 - Aconitate hydratase, mitochondrial - Saccharomyces eubayanus (Yeast) - DI49 2832 gene & proteinDI49 2832 - Aconitate hydratase, mitochondrial - Saccharomyces eubayanus (Yeast) - DI49 2832 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/A0A0L8RGC2
Expression of catalytic subunit of bovine enterokinase in the filamentous fungus Aspergillus nigerExpression of catalytic subunit of bovine enterokinase in the filamentous fungus Aspergillus niger
The cDNA encoding for catalytic subunit of bovine enterokinase (EK(L)), to which the sequence for Kex2 protease cleavage site was inserted, was expressed in the protease deficient filamentous fungus Aspergillus niger AB1.13. Fungal transformants were obtained in which expression of the glucoamylase …
https://pubmed.ncbi.nlm.nih.gov/10656339/
Possible Mosquito Control by Silver Nanoparticles Synthesized by Soil Fungus (Aspergillus niger 2587)Possible Mosquito Control by Silver Nanoparticles Synthesized by Soil Fungus (Aspergillus niger 2587)
Here, we have synthesized the silver nanoparticles (AgNPs) by using the soil fungus Aspergillus niger 2587. The results recorded from UV-vis spectrophotometer and transmission electron microscopy (TEM) support the biosynthesis and characterization of AgNPs. The synthesized silver nanoparticles have also been tested against the larvae and pupae of Anopheles stephensi, Culex quinquefasciatus and Aedes aegypti. The efficacy test was performed at different concentrations for a period of different hours by the probit analysis. The larvae of Cx. quinquefasciatus have shown the 100% mortality to the synthesized AgNPs after 1 h of exposure, while the larvae of An. stephensi and Ae. aegypti were found less susceptible to the synthesized AgNPs. The pupa of Ae. aegypti has shown the efficacy LC50 4, LC90 12 and LC99 19 ppm after 2 h of exposure of the synthesized AgNPs, while, the pupae of Cx. quinquefasciatus and An. stephensi were found less susceptible to the synthesized AgNPs. By this approach, it is
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=31881
Tag Structure and Dynamics of Biomolecules - NeeDoc.Net
Interaction of a C-terminal peptide of Bos taurus diacylglycerol acyltransferase 1 with model membranes Effect of Hydrophobic Interaction on Structure, Dynamics and Reactivity of Water Topics and Timelines Topics and Timelines Structure and mobility of vanadyl(2+) ion in water adsorbed onto silica gels studied by X- and S-band electron spin resonance spectroscopy and by electron nuclear double resonance spectroscopy The buried shape of an alpine valley from gravity surveys, seismic and ambient noise analysis Isolation and characterization of four type 2 ribosome inactivating pulchellin isoforms from Abrus pulchellus seeds
https://docgo.net/tag/structure-and-dynamics-of-biomolecules
Profile - University of HuddersfieldProfile - University of Huddersfield
Dr. Chenyu Du has more than 15 years research experience in fermentation, metabolic engineering, bioprocess development and simulation, bio-separation and biomass pretreatment. He has published 30+ high-impact publications, including 30+ papers, 2 patents and 5 book chapters. Since joined the University of Nottingham, he generated research income over £570 k as PI (including fully funded PhD studentships), £14.3 m as Co-PI and supervised, co-supervised 10 PhD students, 2 MRes students, 15+ MSc students and 15+ undergraduates. At the University of Nottingham, Chenyu has been involved in the research pertaining to the Lignocellosic Conversion to Ethanol programme (LACE programme, funded by BBSRC Sustainable Bioenergy Centre). He developed a solid state fungal fermentation based pre-treatment strategy to convert lignocellulosic raw materials into a mixture of fermentable simple sugars. In this process, cellulolytic enzymes were produced by culturing fungus (Aspergillus niger) directly on the ...
https://research.hud.ac.uk/ourstaff/profile/index.php?staffid=1380
Citrate Utilization Test- Principle, Procedure, Results, UsesCitrate Utilization Test- Principle, Procedure, Results, Uses
Citrate Utilization Test- Principle, Procedure, Results. It identifies organisms capable of using sodium citrate as the sole carbon source.
https://microbenotes.com/citrate-utilization-test-principle-procedure-and-result-interpretation/
Download Associative Functions Triangular Norms And Copulas
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http://ufovideo.net/ebook/download-associative-functions%3A-triangular-norms-and-copulas
3,5-Diethyl 4-[(2-fluorophenyl)carbamoyl]methyl 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate | C22H25FN2O7 - PubChem3,5-Diethyl 4-[(2-fluorophenyl)carbamoyl]methyl 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate | C22H25FN2O7 - PubChem
3,5-Diethyl 4-[(2-fluorophenyl)carbamoyl]methyl 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylate | C22H25FN2O7 | CID 4112238 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/4112238
SAUSA300 1246 - AureoWikiSAUSA300 1246 - AureoWiki
Staphylococcus aureus; strain: USA300_FPR3757; locus tag: SAUSA300_1246 (SAUSA300_RS06765); symbol: citB; product: aconitate hydratase
https://aureowiki.med.uni-greifswald.de/SAUSA300_1246
View source - Wiki FKKT
Slika:Pathways.gif,thumb,right,300px,Shematska slika metabolizma]] Metabolizem je serija povezanih encimsko kataliziranih reakcij znotraj živih organizmov. V osnovi delimo metabolizem na katabolizem in anabolizem. Katabolizem je razgradnja večjih molekul na manjše, anabolizem pa je izgradnja večjih molekul iz manjših. Iz energijskega vidika se omenjena procesa ločita po tem, da pri katabolizmu energija nastaja pri anabolizmu pa se porablja. = Metabolizem ogljikovih hidratov = == Razgradnja glukoze == [[Slika:754px-Citric_acid_cycle_with_aconitate_2.svg.png,thumb,250px,Cikel citronske kisline]] Razgradnja glukoze (osrednji proces na shematski sliki) ima v metabolizmu osrednjo vlogo, saj je ta osnovni proces pridobivanja energije v obliki ATP. Razgradnja glukoze lahko poteka aerobno ali pa anaerobno, pri čemer je večji energetski izkoristek pri aerobnem procesu. Ta dva procesa se razlikujeta po terminalnem akceptorju elektronov. Pri aerobnem procesu je to kisik, pri anaerobnem pa katera ...
http://wiki.fkkt.uni-lj.si/index.php?title=Pregled_metabolizma&action=edit
NCBI Conserved Domain SearchNCBI Conserved Domain Search
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Aconitase catalytic domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. Aconitase, in its active form, contains a 4Fe-4S iron-sulfur cluster; three cysteine residues have been shown to be ligands of the 4Fe-4S cluster. This is the Aconitase core domain, including structural domains 1, 2 and 3, which binds the Fe-S cluster. The aconitase family also contains the following proteins: - Iron-responsive element binding protein (IRE-BP), a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5UTR of ferritin, and delta ...
https://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/Structure/cdd/wrpsb.cgi?seqinput=NP_001163030.1
NCBI Conserved Domain SearchNCBI Conserved Domain Search
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Aconitase catalytic domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. Aconitase, in its active form, contains a 4Fe-4S iron-sulfur cluster; three cysteine residues have been shown to be ligands of the 4Fe-4S cluster. This is the Aconitase core domain, including structural domains 1, 2 and 3, which binds the Fe-S cluster. The aconitase family also contains the following proteins: - Iron-responsive element binding protein (IRE-BP), a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5UTR of ferritin, and delta ...
https://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/Structure/cdd/wrpsb.cgi?seqinput=NP_524708.1
Genome-wide expression profiling of in vivo- derived bloodstream parasite stages and dynamic analysis of mRNA alterations...Genome-wide expression profiling of in vivo- derived bloodstream parasite stages and dynamic analysis of mRNA alterations...
In this paper we describe an analysis of the mRNA expression profile of trypanosomes from two discrete bloodstream form stages of the parasite (slender and stumpy forms), as well as during the transition of the stumpy population to the procyclic life-cycle stage. Although previous analyses have compared either cultured or rodent derived bloodstream form parasites with cultured procyclic forms [37, 38], our analysis represents the first comparison of in vivo derived pleomorphic slender cells with genetically identical stumpy forms, and a first analysis of the dynamic changes in mRNA profile that accompany the transition to procyclic forms. Previous analyses of the differentiation from stumpy to procyclic forms have established that this transition follows a defined and highly reproducible temporal programme, with progression through the major events of differentiation occurring with great synchrony in the population [33]. This provides a considerable power to the analysis of regulated mRNA ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-10-427
Difference between revisions of African Sleeping Sickness: Trypanosome Invasion Mechanism - microbewiki
Upon entrance into the insect from ingesting an infected humans blood, the so called stumpy form of T. brucei enters and must adjust itself to survive within the environment of the fly. This initial transformation is composed of a variety of chemical transformations that are not yet fully understood. It is assumed that proteases that exist within the insects midgut ignite a response to the new environment. [9] Beyond this idea, some believe that the microbe posses a cold-shock response that appears as the microbe travels from the warm-blooded human to the exothermic fly. Despite the controversy of this transformation, the stumpy form of the trypanosome remodels into the first form, the procyclic form. [9] This form only lasts a very short period of time before it transforms again. The microbe attaches itself onto the cells within the gut of the fly, a space referred to as the ecto peritrophic space. The connection to the cells within this space allows the form to change into one more ...
https://microbewiki.kenyon.edu/index.php?title=African_Sleeping_Sickness:_Trypanosome_Invasion_Mechanism&diff=135956
The test-retest reliability of fatty acid taste thresholds - DROThe test-retest reliability of fatty acid taste thresholds - DRO
Newman, Lisa P. and Keast, Russell S.J. 2013, The test-retest reliability of fatty acid taste thresholds, Chemosensory perception, vol. 6, no. 2, pp. 70-77, doi: 10.1007/s12078-013-9143-2. ...
http://dro.deakin.edu.au/view/DU:30053474
Protein: P21399 | MoonDB v2.0Protein: P21399 | MoonDB v2.0
Uniprot: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. more.. ...
http://moondb.hb.univ-amu.fr/protein/P21399
tryp culture commentary
Top of page. Differentiation of BF to PF The most influential proponent of the relationship between morphology, mitochondrial physiology, and life-cycle transitions of T. brucei, in the period from 1960-1980, was Keith Vickerman. His 1965 review [25] is essential reading, and he published other seminal studies on trypanosome morphology and life-cycle changes. His writing is exemplary and persuasive, and his papers are thoroughly documented with references to the prior art. Early indications of major changes in oxidative metabolism during the life cycle are attributable to the biochemical studies of John Ryley and colleagues, during the 1950s and 1960s.. BF differentiates quite readily to PF in vitro. This is what the first cultures, in the early 20th century, represented. It was known for many years that a predominance of stumpy forms led to easier differentiation in culture, and establishment of tsetse infections. In recent years, this has been validated by several labs and it is generally ...
https://tryps.rockefeller.edu/trypsru2_culture_commentary.html
Anti-pneumococcal preparations - Childrens Medical Center CorporationAnti-pneumococcal preparations - Childrens Medical Center Corporation
Disclosed are compositions and methods for treating, reducing or preventing diseases and infections caused by pneumococci. The methods and compositions rely on the use of a CPS-containing composition
https://www.freepatentsonline.com/y2006/0121058.html
Evaluation of Aspergillus niger as host for virus-like particle production, using the hepatitis B surface antigen as a modelEvaluation of Aspergillus niger as host for virus-like particle production, using the hepatitis B surface antigen as a model
The filamentous fungus Aspergillus niger was transformed with the hepatitis B virus S gene encoding the major viral envelope protein under control of the constitutive A. nidulans glyceraldehyde-3-phosphate dehydrogenase (gpdA) promoter. Approximately seven copies of the expression cassette were integrated on the genome, resulting in high-level transcription of the S gene. Production of the 24-kDa S protein and a 48-kDa S protein dimer in the membrane-associated protein fraction of the recombinant A. niger strain was shown through Western analysis. Electron microscopy of partially purified recombinant S protein revealed the formation of spherical pseudoviral particles with a diameter of 22 nm. The production level of hepatitis B pseudoviral particles was estimated to be 0.4 mg/1 culture, which compares favourably with the reported levels initially obtained in yeast, indicating the potential of the Aspergillus expression system as an alternative, cost-effective vaccine production system.. ...
http://scholar.sun.ac.za/handle/10019.1/11998
Expression analysis of alternative oxidase gene (aox1) with enhanced green fluorescent protein as marker in citric acid...
TY - JOUR. T1 - Expression analysis of alternative oxidase gene (aox1) with enhanced green fluorescent protein as marker in citric acid-producing Aspergillus niger. AU - Kirimura, Kohtaro. AU - Ogawa, Satoshi. AU - Hattori, Takasumi. AU - Kino, Kuniki. N1 - Funding Information: We express our thanks to Dr. Y. Niwa of the University of Shizuoka and Professor K. Kitamoto of the University of Tokyo for supplying the plasmid pBEGFP-F harboring the egfp gene. This work was partly supported by the 21COE program Practical Nano-Chemistry from MEXT, Japan.. PY - 2006/9. Y1 - 2006/9. N2 - In a citric acid-producing filamentous fungus Aspergillus niger WU-2223L, a cyanide- and antimycin A-insensitive and salicylhydroxamic acid-sensitive respiratory pathway functions in the mitochondria besides the cytochrome pathway and is catalyzed by alternative oxidase (AOX). We constructed an A. niger transformant strain AOXEGFP-1 expressing a fusion gene, aox1-egfp, encoding AOX and enhanced green fluorescent ...
https://waseda.pure.elsevier.com/ja/publications/expression-analysis-of-alternative-oxidase-gene-aox1-with-enhance
A novel pathway for fungal D-glucuronate catabolism contains an L-idonate forming 2-keto-L-gulonate reductase<...A novel pathway for fungal D-glucuronate catabolism contains an L-idonate forming 2-keto-L-gulonate reductase<...
TY - JOUR. T1 - A novel pathway for fungal D-glucuronate catabolism contains an L-idonate forming 2-keto-L-gulonate reductase. AU - Kuivanen, Joosu. AU - Sugai-Guérios, Maura Harumi. AU - Arvas, Mikko. AU - Richard, Peter. PY - 2016. Y1 - 2016. N2 - For the catabolism of D-glucuronate, different pathways are used by different life forms. The pathways in bacteria and animals are established, however, a fungal pathway has not been described. In this communication, we describe an enzyme that is essential for D-glucuronate catabolism in the filamentous fungus Aspergillus niger. The enzyme has an NADH dependent 2-keto-L-gulonate reductase activity forming L-idonate. The deletion of the corresponding gene, the gluC, results in a phenotype of no growth on D-glucuronate. The open reading frame of the A. niger 2-keto-L-gulonate reductase was expressed as an active protein in the yeast Saccharomyces cerevisiae. A histidine tagged protein was purified and it was demonstrated that the enzyme converts ...
https://cris.vtt.fi/en/publications/a-novel-pathway-for-fungal-d-glucuronate-catabolism-contains-an-l
Biorefinery and SugarcaneBiorefinery and Sugarcane
We have also demonstrated that Louisiana blackstrap molasses can yield 42 percent glycerol and 20 percent bioethanol on fermentable sugars in a special fermentation process. Yeast cells are forced to function under extreme fermentation parameters of high osmotic pressure, pH, temperature and cell concentration. The biorefinery has considerable swing capacity in terms of glycerol versus bioethanol production. Figure 1 shows the basic process and the yields obtainable. Glycerol has numerous applications, such as toothpastes, shampoos, skin care products, polyurethane, cellophane and pharmaceuticals. Inositol is used in baby formula and specialty animal feeds for salmon and shrimp. It is a high value-added product at $5 per pound. Succinic acid is used in photographic and pharmaceutical applications. Aconitic acid is used in rubber and paints. The demand for bioethanol should triple by the year 2010. It is a renewable oxygenate in gasoline, which can be produced economically from molasses without ...
http://www.lsuagcenter.com/portals/communications/publications/agmag/archive/2002/fall/biorefinery-and-sugarcane
Microbiology Society Journals | Succiniclasticum ruminis gen. nov., sp. nov., a Ruminal Bacterium Converting Succinate to...Microbiology Society Journals | Succiniclasticum ruminis gen. nov., sp. nov., a Ruminal Bacterium Converting Succinate to...
A gram-negative, anaerobic, nonmotile, non-spore-forming, rod-shaped bacterium that fermented succinate quantitatively to propionate was isolated from a high dilution of rumen ingesta obtained from a dairy cow fed a production diet containing grass silage as the main roughage source. This organism did not grow on any of the following energy sources: 12 carbohydrates, pyruvate, lactate, 7 dicarboxylic acids, aspartate, citrate, and trans-aconitate. Both rumen fluid and yeast extract were necessary for good growth on succinate. The organism was negative for the following characteristics: production of propionate from threonine, protein digestion, sulfide production, nitrate reduction, catalase activity, and urease activity. There was no growth at 22°C and reduced growth at 45°C compared with growth at 39°C. The DNA base composition was 52 mol% G+C. The complete 16S rRNA sequence (EMBL accession number, X81137) was obtained, and the phylogenetic relationships of the organism were determined. The most
http://ijs.microbiologyresearch.org/content/journal/ijsem/10.1099/00207713-45-2-297
Nigerapyrone A - Aspergillus and AspergillosisNigerapyrone A - Aspergillus and Aspergillosis
Nigerapyrones A-​H, α-​pyrone derivatives from the marine mangrove-​derived endophytic fungus Aspergillus niger MA-​132. Liu, Dong; Li, Xiao-Ming; Meng, Li; Li, Chun-Shun; Gao, Shu-Shan; Shang, Zhuo; Proksch, Peter; Huang, Cai-Guo; Wang, Bin-Gui. Journal of Natural Products (2011), 74(8), 1787-1791.. ...
https://www.aspergillus.org.uk/secondary_metabolite/nigerapyrone-a/
Homoisocitrate dehydrogenase - WikipediaHomoisocitrate dehydrogenase - Wikipedia
Thus, the two substrates of this enzyme are (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate and NAD+, whereas its 4 products are 2-oxoadipate, CO2, NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating). Other names in common use include 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, homoisocitric dehydrogenase, (−)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase, (decarboxylating), 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), and HICDH. This enzyme participates in lysine biosynthesis. ...
https://en.wikipedia.org/wiki/Homoisocitrate_dehydrogenase
JCI - Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumorsJCI - Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors
Control of cellular metabolism is critical for efficient cell function, although little is known about the interplay between cell subset-specific metabolites in situ, especially in the tumor setting. Here, we determined how a macrophage-specific (Mϕ-specific) metabolite, itaconic acid, can regulate tumor progression in the peritoneum. We show that peritoneal tumors (B16 melanoma or ID8 ovarian carcinoma) elicited a fatty acid oxidation-mediated increase in oxidative phosphorylation (OXPHOS) and glycolysis in peritoneal tissue-resident macrophages (pResMϕ). Unbiased metabolomics identified itaconic acid, the product of immune-responsive gene 1-mediated (Irg1-mediated) catabolism of mitochondrial cis-aconitate, among the most highly upregulated metabolites in pResMϕ of tumor-bearing mice. Administration of lentivirally encoded Irg1 shRNA significantly reduced peritoneal tumors. This resulted in reductions in OXPHOS and OXPHOS-driven production of ROS in pResMϕ and ROS-mediated MAPK activation ...
https://www.jci.org/articles/view/99169/figure/1
2-methylcitrate dehydratase - Creative Enzymes2-methylcitrate dehydratase - Creative Enzymes
The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate. The enzyme can also use cis-aconitate as a substrate but more slowly. Bo
https://www.creative-enzymes.com/product/2methylcitrate-Dehydratase_15231.html
ChemIDplus - 2672-58-4 - RGCHNYAILFZUPL-UHFFFAOYSA-N - Trimethyl benzene-1,3,5-tricarboxylate - Similar structures search,...
2672-58-4 - RGCHNYAILFZUPL-UHFFFAOYSA-N - Trimethyl benzene-1,3,5-tricarboxylate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/2672-58-4
Three-dimensional structures of substituted benzylphenyl ethers - dKNAVThree-dimensional structures of substituted benzylphenyl ethers - dKNAV
Forty nine three-dimensional crystal structures of a benzylphenyl ether fragment retrieved from the Cambridge Structural Database were confronted with computed conformational maps of the fragment. Due to the symmetry the number of analyzed fragments rose to 98. When an endocyclic torsion angle of a phenyl ring deviates from 0° the adjacent torsion angle is deformed in opposite direction compensating thus the deviation from planarity. The shape of the fragment is mainly controlled by torsion angles τ,sub,1,/sub, = C-C-O-CH,sub,2,/sub,, τ,sub,2,/sub, = C-O-CH,sub,2,/sub,-C, and τ,sub,3,/sub, = O-CH,sub,2,/sub,-C-C. The attachment of both phenyl rings to the -CH,sub,2,/sub,-O- moiety is not symmetrical and the deformation depends on the value of the τ,sub,3,/sub, angle. In the crystal, the fragment prefers conformation with τ,sub,1,/sub, around 0°, τ,sub,2,/sub, around 180° and with broad bimodal distribution of τ,sub,3,/sub, around 0° and ±90° despite the fact that energetically ...
http://dlib.lib.cas.cz/5148/
The Concept of Reentry - Lullaby Anesthesia Associates LLCThe Concept of Reentry - Lullaby Anesthesia Associates LLC
Drug use and addiction are unfortunately very real pitfalls that some anesthesia providers face. Entering treatment programs and overcoming the addiction can both be very difficult. But what difficulties do anesthesia providers face when they attempt to reenter the field? Is reentry to anesthesia practice even possible? If so, what pathways for reentry are available to assist the provider with a history of drug use and abuse? This article takes a closer look at the process.. ...
https://lullabycrna.com/the-concept-of-reentry/
From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds | Animal SciencesFrom Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds | Animal Sciences
Cheled-Shoval, S. ; Behrens, M. ; Korb, A. ; Di Pizio, A. ; Meyerhof, W. ; Uni, Z. ; Niv, M. Y. From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds. Molecules 2017, 22.
https://animalscience.agri.huji.ac.il/publications/cell-beak-vitro-and-vivo-characterization-chicken-bitter-taste
Trioctyl benzene-1,2,4-tricarboxylate - Registration Dossier - ECHATrioctyl benzene-1,2,4-tricarboxylate - Registration Dossier - ECHA
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.. ...
https://chesar.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/16120/7/5/3
Triisononyl benzene-1,2,4-tricarboxylate - Registration Dossier - ECHATriisononyl benzene-1,2,4-tricarboxylate - Registration Dossier - ECHA
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.. ...
https://chesar.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/27753/7/7/2
The Rest of the Story: Tobacco News Analysis and Commentary: July 2015The Rest of the Story: Tobacco News Analysis and Commentary: July 2015
Acetanisole, · Acetic Acid, · Acetoin, · Acetophenone, · 6-Acetoxydihydrotheaspirane, · 2-Acetyl-3- Ethylpyrazine, · 2-Acetyl-5-Methylfuran, · Acetylpyrazine, · 2-Acetylpyridine, · 3-Acetylpyridine, · 2-Acetylthiazole, · Aconitic Acid, · dl-Alanine, · Alfalfa Extract, · Allspice Extract, · Oleoresin, · And Oil, · Allyl Hexanoate, · Allyl Ionone, · Almond Bitter Oil, · Ambergris Tincture, · Ammonia, · Ammonium Bicarbonate, · Ammonium Hydroxide, · Ammonium Phosphate Dibasic, · Ammonium Sulfide, · Amyl Alcohol, · Amyl Butyrate, · Amyl Formate, · Amyl Octanoate, · alpha-Amylcinnamaldehyde, · Amyris Oil, · trans-Anethole, · Angelica Root Extract, Oil and Seed Oil, · Anise, · Anise Star, Extract and Oils, · Anisyl Acetate, · Anisyl Alcohol, · Anisyl Formate, · Anisyl Phenylacetate, · Apple Juice Concentrate, Extract, and Skins, · Apricot Extract and Juice Concentrate, · 1-Arginine, · Asafetida Fluid Extract And Oil, · Ascorbic Acid, · 1-Asparagine ...
http://tobaccoanalysis.blogspot.fr/2015_07_01_archive.html
Fungi Recycle Lithium-ion BatteriesFungi Recycle Lithium-ion Batteries
A team of researchers is working to use naturally-occurring fungi for an environment-friendly recycling process to extract cobalt and lithium from waste batteries.. Get the Free Tracker App to find a SNES Classic in Stock. The idea first came from a student who had experience extracting some metals from waste slag left over from smelting operations, said Jeffrey A. Cunningham, Ph.D. and the projects team leader.. Cunninghams team is developing the environmentally-safe way to do this with organisms found in nature -- fungi in this case -- and putting them in an environment where they can do their work.. Fungi are a very cheap source of labor, he pointed out in his work to be presented at the 252nd National Meeting & Exposition of the American Chemical Society (ACS).. To drive the process, Cunningham and Valerie Harwood, Ph.D., both at the University of South Florida, are using three strains of fungi -- Aspergillus niger, Penicillium simplicissimum and Penicillium chrysogenum.. The team ...
https://www.i4u.com/2016/08/114548/fungi-recycle-lithium-ion-batteries
Aconitic acidAconitic acid
... is an organic acid. The two isomers are cis-aconitic acid and trans-aconitic acid. The conjugate base of cis- ... Aconitic acid can be synthesized by dehydration of citric acid using sulfuric acid: (HO2CCH2)2C(OH)CO2H → HO2CCH=C(CO2H)CH2CO2H ... aconitic acid, cis-aconitate is an intermediate in the isomerization of citrate to isocitrate in the citric acid cycle. It is ... "Aconitic Acid - Compound Summary (CID 309)". PubChem. Dawson, R. M. C.; Elliott, D. C.; Elliott, W. H. (1989). Data for ...
https://en.wikipedia.org/wiki/Aconitic_acid
Citric acidCitric acid
... aconitic acid, and propane-1,2,3-tricarboxylic acid (tricarballylic acid, carballylic acid) Acids in wine International Union ... Aconitic acid can be synthesized by dehydration of citric acid using sulfuric acid: (HO2CCH2)2C(OH)CO2H → HO2CCH=C(CO2H)CH2CO2H ... Citric acid can be used as an alternative to nitric acid in passivation of stainless steel. Citric acid can be used as a lower- ... Citric acid is an alpha hydroxy acid and is an active ingredient in chemical skin peels. Citric acid is commonly used as a ...
https://en.wikipedia.org/wiki/Citric_acid
Aconitate decarboxylaseAconitate decarboxylase
The properties and reaction mechanism of cis-aconitic acid decarboxylase". J. Biol. Chem. 226 (2): 703-20. PMID 13438855. ... This enzyme participates in c5-branched dibasic acid metabolism. BENTLEY R, THIESSEN CP (1957). "Biosynthesis of itaconic acid ... Other names in common use include cis-aconitic decarboxylase, CAD, cis-aconitate carboxy-lyase, and cis-aconitate carboxy-lyase ...
https://en.wikipedia.org/wiki/Aconitate_decarboxylase
ImideImide
ISBN 978-0-9678550-9-7. Martynov, A. V. (2005-12-06). "New Approach to the Synthesis of trans-Aconitic Acid Imides". ChemInform ... Most imides are cyclic compounds derived from dicarboxylic acids, and their names reflect the parent acid. Examples are ... The intramolecular reaction of a carboxylic acid with an amide is far faster than the intermolecular reaction, which is rarely ... One example is Kapton where the repeat unit consists of two imide groups derived from aromatic tetracarboxylic acids. Another ...
https://en.wikipedia.org/wiki/Imide
Adonis vernalisAdonis vernalis
The plant is poisonous, containing cardiostimulant compounds, such as adonidin and aconitic acid. Infusions of the plant are ...
https://en.wikipedia.org/wiki/Adonis_vernalis
Homoaconitic acidHomoaconitic acid
Homoaconitatic acid (homoaconitate) is related to aconitic acid but with one extra carbon. It is part of the α-aminoadipate ... Homoisocitric acid Murray Strassman and Louis N. Ceci (1966). "Enzymatic Formation of cis-Homoaconitic Acid, an Intermediate in ... Tricarboxylic acids, All stub articles, Organic compound stubs). ...
https://en.wikipedia.org/wiki/Homoaconitic_acid
Grass tetanyGrass tetany
Effect of tricarballylic acid, a nonmetabolizable rumen fermentation product of trans-aconitic acid, on Mg, Ca and Zn ... Enrichment and isolation of rumen bacteria that reduce trans-aconitic acid to tricarballylic acid. Appl. Env. Microbiol. 49: ... Potassium fertilizer application results in increased concentration of aconitic acid in some grass species. Magnesium ... Potassium effects on minerals and organic acids in three cool-season grasses. J. Plant Nutr. 15: 1007-1025. Gustav Rosenberger ...
https://en.wikipedia.org/wiki/Grass_tetany
Itaconic acidItaconic acid
The name itaconic acid was devised as an anagram of aconitic acid, another derivative of citric acid. Since the 1960s, it is ... 2-methylmaleic acid). Partial hydrogenation of itaconic acid over Raney nickel affords 2-methylsuccinic acid. Itaconic acid is ... Itaconic acid, or methylidenesuccinic acid, is an organic compound. This dicarboxylic acid is a white solid that is soluble in ... Historically, itaconic acid was obtained by the distillation of citric acid, but currently it is produced by fermentation. ...
https://en.wikipedia.org/wiki/Itaconic_acid
Maleic anhydrideMaleic anhydride
These intermediates were subsequently used for the generation of the Krebs cycle intermediates aconitic and isocitric acids. ... It is the acid anhydride of maleic acid. It is a colorless or white solid with an acrid odor. It is produced industrially on a ... Maleic acid is biodegradable under aerobic conditions in sewage sludge as well as in soil and water. Food starch for use in ... It hydrolyzes, producing maleic acid, cis-HOOC-CH=CH-COOH. With alcohols, the half-ester is generated, e.g., cis-HOOC-CH=CH- ...
https://en.wikipedia.org/wiki/Maleic_anhydride
Alisma orientaleAlisma orientale
The seed contains cis-aconitic anhydride ethyl ester and cis-2,4,5-trihydroxycinnamic acid. English Names for Korean Native ... Zhao M, Chen JY, Xu LJ, Goedecke T, Zhang XQ, Duan JA, Che CT (2012). "Cis-aconitic anhydride ethyl ester and phenolic ...
https://en.wikipedia.org/wiki/Alisma_orientale
Aconitum soongaricumAconitum soongaricum
All parts of the plant contain alkaloids associated with aconitic acid (primarily aconitine), but their concentration depends ...
https://en.wikipedia.org/wiki/Aconitum_soongaricum
Aspergillus terreusAspergillus terreus
A. terreus is commonly used in industry to produce important organic acids, such as itaconic acid and cis-aconitic acid, as ... The polyketide synthase gene atX produces 6-Methylsalicylic acid in A. terreus. Aspergillus terreus is not as common as other ... Shimada, A; Kusano,M; Takeuchi,S; Fujioka,S; Inokuchi,T; Kimura, Y (2002). "Aspterric acid and 6-hydroxymellein, inhibitors of ... Its secondary metabolites, aspterric acid and 6-hydroxymellein, released from the fungus inhibit the production of pollen, the ...
https://en.wikipedia.org/wiki/Aspergillus_terreus
Propane-1,2,3-tricarboxylic acidPropane-1,2,3-tricarboxylic acid
Citric acid Aconitic acid Isocitric acid Aconitase normally catalyses, via the intermediate aconitic acid, the interconversion ... Propane-1,2,3-tricarboxylic acid, also known as tricarballylic acid, carballylic acid, and β-carboxyglutaric acid, is a ... However, the hydroxide group is essential to proceed from citric acid to aconitic acid, therefore the enzyme is not able to ... such as actinoplanic acid. Propane-1,2,3-tricarboxylic acid can be synthesized in two steps from fumaric acid. ...
https://en.wikipedia.org/wiki/Propane-1,2,3-tricarboxylic_acid
C6H6O6C6H6O6
Acetic oxalic anhydride Aconitic acid Benzenehexol Dehydroascorbic acid (DHA) 1,2,3,4,5,6,-hexa hydroxy benzen This set index ...
https://en.wikipedia.org/wiki/C6H6O6
AconitaseAconitase
Citric acid Aconitic acid Isocitric acid Aconitase, displayed in the structures in the right margin of this page, has two ... However, aconitase cannot bind this substrate and thus the citric acid cycle is halted. The iron sulfur cluster is highly ... Takusagawa F. "Chapter 16: Citric Acid Cycle" (PDF). Takusagawa's Note. The University of Kansas. Archived from the original ( ... Fluoroacetate, in the citric acid cycle, can innocently enter as fluorocitrate. ...
https://en.wikipedia.org/wiki/Aconitase
List of additives in cigarettesList of additives in cigarettes
2-Acetyl-3-ethylpyrazine 2-Acetyl-5-methylfuran Acetylpyrazine 2-Acetylpyridine 3-Acetylpyridine 2-Acetylthiazole Aconitic acid ... Acid alpha-Methylcinnamaldehyde Methylcyclopentenolone 2-Methylheptanoic Acid 2-Methylhexanoic Acid 3-Methylpentanoic Acid 4- ... 12-Octadecadienoic acid (48%) and 9,12,15-Octadecatrienoic acid (52%) delta-Octalactone gamma-Octalactone Octanal Octanoic acid ... Kola Nut Extract Labdanum Absolute and Oleoresin Lactic Acid Lauric Acid Lauric Aldehyde Lavandin Oil Lavender oil Lemon Oil ...
https://en.wikipedia.org/wiki/List_of_additives_in_cigarettes
2,4,5-Trihydroxycinnamic acid2,4,5-Trihydroxycinnamic acid
"Cis-aconitic anhydride ethyl ester and phenolic compounds from the seeds of Alisma orientale". Natural Product Communications. ... 2,4,5-Trihydroxycinnamic acid is a hydroxycinnamic acid found in rooibos tea. cis-2,4,5-Trihydroxycinnamic acid can be isolated ... Hydroxycinnamic acids, Hydroxyquinols, Vinylogous carboxylic acids, All stub articles, Aromatic compound stubs). ...
https://en.wikipedia.org/wiki/2,4,5-Trihydroxycinnamic_acid
List of MeSH codes (D02)List of MeSH codes (D02)
... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ... muramic acids MeSH D02.241.081.844.562 - neuraminic acids MeSH D02.241.081.844.562.668 - sialic acids MeSH D02.241.081.844. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
Cas 77-89-4,Triethyl acetyl citrate | lookchemCas 77-89-4,Triethyl acetyl citrate | lookchem
aconitic acid triethyl ester aconitic acid triethyl ester Conditions. Conditions. Yield. at 250 - 280℃;. ... ATEC is produced by the reaction of citric acid triethyl ester with acetic acid anhydride. It is used as a solvent plasticizer ... Citric acid, acetyl triethyl ester;Citric acid, triethyl ester, acetate;citricacid,acetyltriethylester;citricacid,triethylester ... sulfuric acid at 80℃; for 3h;. 88%. With H-type zeolite catalyst at 60 - 120℃; under 760.051 Torr; for 2.83333h; Reagent/ ...
https://www.lookchem.com/casno77-89-4.html
2,4,5-trimethyl thiazole, 13623-11-52,4,5-trimethyl thiazole, 13623-11-5
aconitic acid. FL. 3,6-. cocoa pyrazine. FL/FR. 3,5(6)- ...
http://www.thegoodscentscompany.com/data/rw1008831.html
The urinary metabolomics profile of an Italian autistic children population and their unaffected siblingsThe urinary metabolomics profile of an Italian autistic children population and their unaffected siblings
... glycolic acid and glycine, cis-aconitic acid; phenylalanine, tyrosine, p-hydroxyphenylacetic acid, and homovanillic acid are ... Results: Children with autistic disease composing our studied population showed elevated concentration of several organic acids ... Among them, the 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid has been previously described as altered in autistic subjects. ...
https://pubmed.ncbi.nlm.nih.gov/25284177/
MeSH BrowserMeSH Browser
Carboxylic Acids [D02.241] * Acids, Acyclic [D02.241.081] * Tricarboxylic Acids [D02.241.081.901] * Aconitic Acid [D02.241. ... Achilleic Acid Aconitate Carboxyglutaconic Acid Citridic Acid Citridinic Acid Equisetic Acid Pyrocitric Acid Registry Number. ... A tricarboxylic acid with the formula (COOH)-CH2-C(COOH)=CH-COOH.. Terms. Aconitic Acid Preferred Term Term UI T000447. Date01/ ... Citridic Acid Narrower Concept UI. M000642246. Registry Number. 0. Terms. Citridic Acid Preferred Term Term UI T000451. Date08/ ...
https://meshb.nlm.nih.gov/record/ui?ui=D000156
Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model - Fingerprint - UC...
Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model. ... Dive into the research topics of Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat ...
https://ucdavis.pure.elsevier.com/en/publications/plasma-amino-acid-and-metabolite-signatures-tracking-diabetes-pro/fingerprints/
CN111593380A - Acidic electro-galvanized iron alloy plating solution additive for high-iron-content plating layer and...
Because the hydrophilic acid groups in the added organic acid are combined with the metal matrix, a uniform electroplating ... Meanwhile, the alkyl group of the aliphatic polycarboxylic acid deviates from the metal group, has hydrophobicity, can repel ... of organic acid and 10-90% of water or/and ethanol; the high-iron content means that the iron content in the zinc-iron alloy ... GTZCVFVGUGFEME-IWQZZHSRSA-N cis-aconitic acid Chemical compound data:image/svg+xml;base64, ...
https://patents.google.com/patent/CN111593380A/en
Other Reference Material | ChromaDex StandardsOther Reference Material | ChromaDex Standards
Fatty Acids*Fatty acid alcohols. *Fatty acid esters. *Fatty acidsFatty acid lactones ...
https://standards.chromadex.com/reference-standard-material/Other-Reference-Material
MeSH BrowserMeSH Browser
Carboxylic Acids [D02.241] * Acids, Acyclic [D02.241.081] * Tricarboxylic Acids [D02.241.081.901] * Aconitic Acid [D02.241. ... Achilleic Acid Aconitate Carboxyglutaconic Acid Citridic Acid Citridinic Acid Equisetic Acid Pyrocitric Acid Registry Number. ... A tricarboxylic acid with the formula (COOH)-CH2-C(COOH)=CH-COOH.. Terms. Aconitic Acid Preferred Term Term UI T000447. Date01/ ... Citridic Acid Narrower Concept UI. M000642246. Registry Number. 0. Terms. Citridic Acid Preferred Term Term UI T000451. Date08/ ...
https://meshb-prev.nlm.nih.gov/record/ui?ui=D000156
Trisodium citrate dihydrate | 6132-04-3Trisodium citrate dihydrate | 6132-04-3
Its decomposition pathways are generally going through aconitic acid, itaconic acid, citraconic acid anhydride to be further ... abs9147;NATRII CITRAS;Citratic acid;CITRIC ACID H2O;CITRIC ACID MON;CITRIC ACID MONO;CITRIC ACID BP93;SodiumCitrateBp93;SODIUM ... SQUALESTATIN DL-MALIC ACID MONOSODIUM SALT succinic acid, sodium salt (+/-)-CITRAMALIC ACID SODIUM SALT Sodium malate L(-)- ... 3-HYDROXYBUTYRIC ACID, SODIUM SALT DECALCIFYING SOLUTION DL-Malic acid disodium salt GLUTARIC ACID SODIUM SALT Disodium citrate ...
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB9752065.htm
Acids and bases from A to Z - ingredientsAcids and bases from A to Z - ingredients
Acids somehow have a spectacular image in skin care. They either have caustic effects in the true sense of the word or they are ... Acids in cosmetic products. Aconitic acid (1,2,3-propene tricarboxylic acid) is a component of Christmas rose or yarrow ... Mineral acids: The following strong inorganic acids belong to the mineral acids: hydrochloric acid, sulfuric acid, nitric acid ... Unsaturated fatty acids are e.g. oleic acid and linoleic acid, α- and γ-linolenic acid. The last named three acids are ...
https://dermaviduals.de/english/publications/ingredients/acids-and-bases-from-a-to-z.html
Approved List of Additives - The Online Tobacco Seed StoreApproved List of Additives - The Online Tobacco Seed Store
Aconitic Acid. *dl-Alanine. *Alfalfa Extract. *Aluminum (Metal). *Allspice Extract. *Oleoresin. *And Oil ...
https://www.onlinetobaccoseedstore.com/approved-list-of-additives/
Paper Bound Copies of WrightsPaper Bound Copies of Wright's
Constituents-Resin, aconitic acid; alkaloids consisting, in part, of aconitine, isaconitine, aconine, picraconitine, etc. ... Constituents-Lichenin and isolichenin, cetraric acid, lichen-stearic acid, fumaric acid, oxalic acid, cellulose, etc. ... Constituents-Kinic acid, kinovic acid, kino- ■vin, cinchotannic acid. Most important con- stituents are the five alkaloids, viz ... Constituents-Volatile oil, bitter principle, resins, copaivic acid, oxycopaivic acid, met- acopaivic acid, etc. Properties- ...
https://collections.nlm.nih.gov/ocr/nlm:nlmuid-61841080R-bk
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation - Fingerprint - Okayama...
Aconitic Acid 94% * N,N-dimethylarginine 74% * Chronic Renal Insufficiency 73% * Inflammation 47% ...
https://okayama.pure.elsevier.com/en/publications/slco4c1-transporter-eliminates-uremic-toxins-and-attenuates-hyper/fingerprints/
pH of Organic Acids and SaltspH of Organic Acids and Salts
2-oxobutanoic acid. alpha-ketobutyric acid. 3.11. 2.38. 1.79. C6H6O6. trans-aconitic acid. 3.14. 2.48. 1.92. ... protocatechuic acid. 3,4-dihydroxybenzoic acid. 3.78. 3.25. 2.74. C7H6O5. gallic acid. 3,4,5-trihydroxybenz. acid. 3.75. 3.22. ... cinnamic acid. trans-cinnamic acid. 3.76. 3.23. 2.72. C7H6O4. protocatechuic acid. 3,4-dihydroxybenzoic acid. 3.78. 3.25. 2.74 ... pH of Organic Acids and Salts. Based on given acidity constants (pKa values) the pH of organic acids for 1, 10, and 100 mmol/L ...
https://www.aqion.de/site/192
1-Propene-1,2,3-tricarboxylic acid, tris(trimethylsilyl) ester, (Z)- (CAS 55530-71-7) - Chemical & Physical Properties by Cheméo1-Propene-1,2,3-tricarboxylic acid, tris(trimethylsilyl) ester, (Z)- (CAS 55530-71-7) - Chemical & Physical Properties by Cheméo
cis-Aconitic acid (3TMS). *cis-Aconitic acid (tms). *cis-Aconitic acid, tris(trimethylsilyl) ester ... Find more compounds similar to 1-Propene-1,2,3-tricarboxylic acid, tris(trimethylsilyl) ester, (Z)-. ... Chemical Properties of 1-Propene-1,2,3-tricarboxylic acid, tris(trimethylsilyl) ester, (Z)- (CAS 55530-71-7). ... Z)-Aconitic acid, tris-TMS. *Aconitic acid, (z)-, 3tms derivative. * ...
https://www.chemeo.com/cid/60-071-6/1-Propene-1,2,3-tricarboxylic%20acid,%20tris%28trimethylsilyl%29%20ester,%20%28Z%29-
Complete genome sequence of acidaminococcus fermentans type strain (VR4 <sup>T<...
Aconitic Acid Medicine & Life Sciences 45% * Genome Medicine & Life Sciences 34% * Firmicutes Medicine & Life Sciences 34% ...
https://ucdavis.pure.elsevier.com/en/publications/complete-genome-sequence-of-acidaminococcus-fermentans-type-strai
Krebs cycle (Citric Acid Cycle) : High Yield Notes with Mnemonics | medicomaestroKreb's cycle (Citric Acid Cycle) : High Yield Notes with Mnemonics | medicomaestro
Citric Acid Cycle) : High Yield Notes with Mnemonics Mnemonic for Enzymes and Steps in Krebs Cycle: Our City Is Kept Safe And ... Aconitase (Aconitic acid is a dehydrated citric acid). *Isocitrate. Isocitrate dehydrogenase (dehydrogenated H+ added to NAD to ... Acetyl-CoA is yielded from glucose, fatty acids, ketone bodies, ketogenic amino acids and alcohol. ... lipoic acid, CoA, FAD, NAD) Lack of thiamine slows oxidation of acetyl-CoA in citric acid cycle ...
https://medicomaestro.com/krebs-cycle-citric-acid-cycle-high-yield-notes-with-mnemonics/
NDC Active Ingredient Ascorbic AcidNDC Active Ingredient Ascorbic Acid
List of the 215 NDC products with the active ingredient Ascorbic Acid. ... alpha.-ketoglutaric Acid - Aconitic Acid, Cis - Adenosine Triphosphate - Alpha .... Pellet. Oral. Guna Spa. Human Otc Drug. ... alpha.-ketoglutaric Acid - Alpha Lipoic Acid - Ascorbic Acid - Barium Oxalosucc.... Solution/ Drops. Oral. Guna Spa. Human Otc ... L-ascorbic Acid. Liquid. Topical. Organelle Inc. Human Otc Drug. 75768-0005. New Clairfore L-ascorbic Acid. Liquid. Topical. ...
https://ndclist.com/active-ingredients/ascorbic-acid
NDF-RT Code NDF-RT NameNDF-RT Code NDF-RT Name
Phosphate Fluoride N0000007192 Acitretin N0000168464 Aclarubicin N0000168024 Aconitate Hydratase N0000166736 Aconitic Acid ... Neutral N0000006806 Amino Acids N0000011372 Amino Acids, Acidic N0000011248 Amino Acids, Aromatic N0000011332 Amino Acids, ... Acyclic N0000008269 Acids, Aldehydic N0000007628 Acids, Carbocyclic N0000007629 Acids, Heterocyclic N0000007630 Acids, ... Amino Acid Isomerases N0000167825 Amino Acid Oxidoreductases N0000169801 Amino Acid Transport System A N0000169803 Amino Acid ...
https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/StructuralClass%202012-06-04.txt
Mitochondrial enzymes and chromaffin granules - WikidataMitochondrial enzymes and chromaffin granules - Wikidata
Spectrophotometric measurements of the enzymatic formation of fumaric and cis-aconitic acids ...
https://m.wikidata.org/wiki/Q74751215
研究成果を検索 - 早稲田大学
Bioproduction of trans-Aconitic Acid from Citric Acid by Whole-Cell Reaction of Escherichia coli Heterologously Expressing the ... Nucleic Acids Research. 44, 1, p. 472-484 13 p.. 研究成果: Article › 査読 ...
https://waseda.pure.elsevier.com/ja/publications/?ordering=publicationYearThenTitle&descending=false&showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=&format=&page=1099
Advanced Guide to Choline in Nootropic Stacks - Nootropics ExpertAdvanced Guide to Choline in Nootropic Stacks - Nootropics Expert
Citrate then acts as the substrate for aconitase and is converted in aconitic acid. This cycle ends with the regeneration of ... Citrate is an intermediate in the Krebs cycle (also known as the TCA cycle or Tricarboxylic Acid cycle, or Citric acid cycle). ... The combination of the omega-3 fatty acid DHA, Alpha GPC, and phosphatidylserine (PS) is used to form brain cell membranes.[ii] ... I am about to order Super R-lipoic acid from Life extension brand. Ive listened to one of your videos on youtube about the ...
https://nootropicsexpert.com/advanced-guide-to-choline-in-nootropic-stacks/comment-page-1/?replytocom=10718
Hair Care | Find Me A Cure
The plant contains equisetic acid, which is thought to be identical to aconitic acid. This substance is a potent heart and ... Salmon : It contains vitamin D and omega-3 fatty acids. This omega-3 fatty acid is very much essential to keep your scalp and ... Lentils are rich in folic acid. Presence of folic acid helps in providing the requisite amount of oxygen to your scalp and skin ... Aloe Vera, Andrographis paniculata, Antibacterial, Ascorbic acid, Hair Care, Leaf, Organic certification, PH, Plant, Tea ...
https://findmeacure.com/tag/hair-care/
AOPA In Advance SmartBrief
The Audubon Sugar Institute at Louisiana State University has discovered that aconitic acid, found in cane and sweet sorghum ...
https://www2.smartbrief.com/servlet/encodeServlet?issueid=4A3E9CA0-100A-43AC-8559-74AE06617A1F&sid=45bcf413-e5f0-4e9e-a67c-47633df989bd
SMPDBSMPDB
L-Malic acid. H. 2. O. NAD. NADH. H. +. ATP. HCO. 3. -. ADP. P. i. Q. FAD. QH. 2. cis-Aconitic acid. H. 2. O. H. 2. O. Thiamine ... Fatty Acids. Propanoate. Metabolism. Inner mitochondrial membrane. Mitochondrial intermembrane. space. Cytosol. Mitochondrial ... Pyruvic acid. CoA. NAD. CO. 2. NADH. H. 2. O. Citric acid. CoA. Isocitric acid. NAD. CO. 2. NADH. H. +. NAD. CoA. Succinyl-CoA ... Pyruvic acid. Oxalacetic acid. Accumulation. Fumaric acid. Succinic acid. FADH. 2. Accumulation. Oxoglutaric acid. Acetyl-CoA. ...
https://smpdb.ca/view/SMP0000549?highlight%5Bcompounds%5D%5B%5D=HMDB0001273
Ativisha - Aconitum heterophyllumAtivisha - Aconitum heterophyllum
aconitic acid, tannic acid, pectin, starch, oleic acid, palmitic acid, stearicglycerides.. Parts Used of Ativisha - Aconitum ... proteins and amino acids, saponins, glycosides, quinones, flavonoids, terpenoids, etc. ...
https://www.iafaforallergy.com/herbs-a-to-z/ativisha-aconitum-heterophyllum/
Metabolomic Profiles in IBS, UC, and Healthy ControlsMetabolomic Profiles in IBS, UC, and Healthy Controls
Monocarboxylic acids. p-Hydroxyphenylacetic acid. Monocarboxylic acids. Suberic acid. Dicarboxylic acids. Trans-Aconitic acid. ... Sumikis acid. 5-(Hydroxymethyl)furan-2-carboxylic acid. Monocarboxylic acids. ortho-Hydroxyphenylacetic acid. Monocarboxylic ... Glutamic acidc 6.386 (2.700-10.887). 84.074 (61.700-147.195). ,0.001. ,0.001. Ethylmalonic acidd 0.260 (0.053-1.016). 3.003 ( ... Palmitic acidd 11.592 (5.646-18.580). 17.828 (16.392-19.331). 0.002. 0.048. Hippuric acidd 97.677 (67.233-123.795). 159.070 ( ...
http://www.medscape.com/viewarticle/909751
Toxic plants for horses - ehorses MagazineToxic plants for horses - ehorses Magazine
The plant is highly toxic due to alkali, traces of nictoin, aconitic acid, and the enzyme thiaminase. 20% of marsh horsetail in ... Toxins are thiaminase, hydrocyanic acid glycosides and saponin. 2-3 kg over a period of 30 days can be fatal for the horse. ... They contain the toxic substances saponins and oxalic acid. These have a high degree of toxicity for horses and are already ...
https://www.ehorses.com/magazine/toxic-plants-for-horses/
Plasma metabolomic study in perinatally HIV-infected children using 1H NMR spectroscopy reveals perturbed metabolites that...Plasma metabolomic study in perinatally HIV-infected children using 1H NMR spectroscopy reveals perturbed metabolites that...
... cis-aconitic acid, 31- β−glucose, 32- glycine, 33- myo-inositol, 34- glucono-1,5-lactone, 35- N-methyl-a-aminoisobutyric acid, ... Our results showed elevated levels of lactate, glucose, phosphoenolpyruvic acid, propionic acid, 2-ketobutyric acid and ... ART normalized the levels of several metabolites, however the level of lactate, phosphoenolpyruvic acid, oxoglutaric acid, ... 1‐ Leucine, 2- valine, 3-2-Ketobutyric acid, 4- ethanol, 5- β-hydroxybutyrate, 6- lactate, 7- dimethylmalonic acid, 8- alanine ...
https://pubmed.ncbi.nlm.nih.gov/32866201/
Citric acidTrans-aconiticFatty acidsFumaricCarboxylic acidsAminoMalic acidAnti-inflammatoryProteinsSuccinicMethylmalonic AcidMetabolitesCompoundsCompoundKynurenicConcentrationAcrylicExcretionReaction productPredominantOralMagnesiumVitaminSignificantFractionAlphaEffectsEffectClinicalResult is tooPresent
Citric acid4
  • Citric Acid is an acidulant and antioxidant produced by mold fer- mentation of sugar solutions and by extraction from lemon juice, lime juice, and pineapple canning residue. (lookchem.com)
  • anhydrous citric acid has a solubility of 146 g and mono- hydrate citric acid has a solubility of 175 g/100 ml of distilled water at 20°c. a 1% solution has a ph of 2.3 at 25°c. it is a hygroscopic, strong acid of tart flavor. (lookchem.com)
  • It involves many 3-C compounds such as citric acid, cis-aconitic acid and iso-citric acid etc., so it is also called TCA cycle or tricarboxylic acid, cycle. (askfilo.com)
  • It involves formation of citric acid as its first product so it is called citric acid cycle. (askfilo.com)
Trans-aconitic2
  • Reactiv ROTH trans-Aconitic acid min. (amex-lab.ro)
  • The major acid is the tricarboxylic acid, trans-aconitic acid, which is determined spectrophotometrically. (massey.ac.nz)
Fatty acids6
  • FOOD ADDITIVES;Water Ttreatment Chemicals;CI - CLOther Lipid Related Products;NeatsChromatography;Alphabetic;C;Fatty AcidsFA/FAME/Lipids/Steroids;Food&Beverage Standards;Free Fatty Acids;Lipid Analytical Standards;Organic Acids;C6Biochemicals and Reagents;Other BiochemicalMore. (lookchem.com)
  • Combining with the up-regulation of glutamate decarboxylase and succinic semialdehyde dehydrogenase in GABA shunt, and the phosphoenolpyruvate carboxykinase in the central hub involving pyruvate/phosphoenolpyruvate/oxaloacetate, the products from nitrogen-containing compounds degradation were recycled to be intermediates of TCA cycle and be shunted toward de novo biosynthesis of fatty acids. (biomedcentral.com)
  • In addition, ATP from substrate phosphorylation was presumed to be a critical factor regulation of the global resource allocation and fatty acids' synthesis rate. (biomedcentral.com)
  • Since the branched-chain fatty acids are high-normal, the problem seems to be that they are not being fed into the Krebs cycle. (phoenixrising.me)
  • 7. The ketone and fatty acids metabolites are somewhat elevated. (phoenixrising.me)
  • This causes the cells to mobilize fatty acids, and they also appear to have difficulty entering the Krebs cycle, and are hence being shunted to omega oxidation. (phoenixrising.me)
Fumaric1
  • The invention relates to a process for the production of foamable copolymers, to foamable copolymers and to foamable polymer structures based on itaconic acid, mesaconic acid, fumaric acid, maleic acid, aconitic acid, and glutaconic acid. (justia.com)
Carboxylic acids4
  • Definition: Carboxylic acids are organic acids characterized by the presence of a carboxyl group, which has the formula -C(=O)OH, usually written -COOH or -CO2H. (humpath.com)
  • Carboxylic acids are Brønsted-Lowry acids and are proton donors. (humpath.com)
  • Salts and anions of carboxylic acids are called carboxylates. (humpath.com)
  • The simplest series of carboxylic acids are the alkanoic acids, R-COOH, where R is a hydrogen or an alkyl group. (humpath.com)
Amino1
  • 2. Rate of incorporation in vitro of radioactive amino acids into soluble proteins in the mitochondrial fraction, including catalase, malic dehydrogenase and cytochrome c. (wikidata.org)
Malic acid1
  • 6. Succinic acid is relatively low, and malic acid is below the detection limit. (phoenixrising.me)
Anti-inflammatory2
  • cis-Aconitic acid reduced in vitro the release of TNF-α and phosphorylation of IκBα in lipopolysaccharide-stimulated THP-1 macrophages, suggesting that inhibition of nuclear factor kappa B activation was an underlying mechanism of cis-aconitic acid-induced anti-inflammatory effects. (bvsalud.org)
  • In conclusion, cis-aconitic acid has significant anti-inflammatory effects in antigen-induced arthritis and monosodium urate-induced arthritis in mice, suggesting its potential for the treatment of inflammatory diseases of the joint in humans. (bvsalud.org)
Proteins1
  • Transcriptomic analysis from Tead1-knockout myocardium revealed genes encoding oxidative phosphorylation, TCA cycle, and fatty acid oxidation proteins as the top differentially enriched gene sets. (bvsalud.org)
Succinic2
  • This suggests that it is being fed by glutamate, which is also high, and that the flow from AKG to succinic acid is partially blocked. (phoenixrising.me)
  • Again, the low succinic and malic acids will also contribute to low ATP production by the mitochondria, contributing to the fatigue. (phoenixrising.me)
Methylmalonic Acid1
  • The explanation appears to be a functional deficiency in B12, given the high-normal methylmalonic acid. (phoenixrising.me)
Metabolites1
  • Several clinical studies have reported increased excretion of anthranilic acid and other metabolites in bladder cancer patients. (healthmatters.io)
Compounds1
  • Compounds may also have two or more carboxylic acid groups per molecule. (humpath.com)
Compound2
  • PubChem Compound Summary for CID 309, Aconitic acid. (vibratist.com)
  • https://pubchem.ncbi.nlm.nih.gov/compound/Aconitic acid. (vibratist.com)
Kynurenic1
  • In a mathematical model without a tryptophan load, a moderate B6 deficiency resulted in slight decreases in kynurenic and anthranilic acids. (healthmatters.io)
Concentration1
Acrylic1
  • A process for preparing (meth)acrylic esters (F) of hydroxy-functional aromas (A), in which at least one hydroxy-functional aroma (A) in the presence of at least one enzyme (E) is esterified with (meth)acrylic acid (S), or transesterified with at least one (meth)acrylic ester (D), the reaction in the case of the transesterification being effected in the absence of solvents. (justia.com)
Excretion2
  • Patients with acute intermittent porphyria had significantly increased urinary excretion of kynurenine and anthranilic acid. (healthmatters.io)
  • Measurement of 4-hydroxyphenylacetic acid excretion in urine is useful in screening for diseases of the small intestine associated with bacterial overgrowth. (healthmatters.io)
Reaction product1
  • The present invention relates to a process for the preparation of unsaturated acylamidoalkylpolyhydroxy acid amides by reacting the reaction product of polyhydroxy acid lactone and aliphatic diamine with the anhydride of a monounsaturated carboxylic acid, to the unsaturated acylamidoalkylpolyhydroxy acid amides and also to a process for the preparation of polymers of unsaturated acylamidoalkylpolyhydroxy acid amides. (justia.com)
Predominant1
  • it is the predominant acid in oranges, lemons, and limes. (lookchem.com)
Oral1
  • Oral treatment with cis-aconitic acid (10, 30, and 90 mg/kg) reduced leukocyte accumulation in the joint cavity and C-X-C motif chemokine ligand 1 and IL-1ß levels in periarticular tissue. (bvsalud.org)
Magnesium1
  • This suggests a partial block in the pyruvate dehydrogenase complex, which could be due to deficiniencies in B vitamins, lipoic acid and/or magnesium. (phoenixrising.me)
Vitamin1
  • Anthranilic acid activity may be reduced during vitamin B6 restriction. (healthmatters.io)
Significant1
  • The pectic substances, lignin and the organic acids are effective in complexing a large proportion of the solution Ca in a non-ionic form but only lignin and the organic acids display a significant complexing of solution Mg++. (massey.ac.nz)
Fraction1
  • The pectic fraction isolated from Yorkshire fog is approximately 90% polygalacturonic acid while the hemicelluloses are basically arabinoxylans with varying hexose and uronic acid content. (massey.ac.nz)
Alpha1
  • The combination of the omega-3 fatty acid DHA , Alpha GPC , and phosphatidylserine (PS) is used to form brain cell membranes. (nootropicsexpert.com)
Effects2
  • cis-Aconitic acid treatment reduced joint inflammation in tissue sections of antigen-induced arthritis mice and these effects were associated with decreased mechanical hypernociception. (bvsalud.org)
  • Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. (usda.gov)
Effect2
  • The present study aimed to investigate the anti-arthritic effect of cis-aconitic acid in murine models of antigen-induced arthritis and monosodium urate-induced gout. (bvsalud.org)
  • The effect of boric acid on rooting of cuttings initially high in boron 9. (studylib.net)
Clinical1
  • Organic acid testing is strongly recommended as an initial clinical screening tool whereas the GPL-TOX test is an important tool for assessing exposure to common environmental toxins. (regeneruslabs-myportal.com)
Result is too1
  • What does it mean if your Anthranilic Acid result is too low? (healthmatters.io)
Present1
  • The normal plant acids, citric and malic, are present in moderate quantities while the alicyclic acids, quinic anc shikimic, are only present in minor amounts. (massey.ac.nz)