An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Evidence of the role of protein kinase C during aclacinomycin induction of erythroid differentiation in K562 cells. (1/93)

At subtoxic concentrations, aclacinomycin is effective in controlling erythroid differentiation of K562, a human erythroleukemic cell line. To better understand early events implicated in this process, we have used bisindolylmaleimide (GF109203X), an inhibitor with a high selectivity for protein kinase C (PKC). Our data show that GF109203X inhibits aclacinomycin effects on K562, evidenced by a strong reduction of hemoglobinized cells and a marked decrease of mRNA rates of erythroid genes. To establish firmly PKC involvement, we also verified that aclacinomycin stimulates its rapid translocation, from the cytosolic to the membrane compartment. By Western blot analysis, we also show that after short induction times, PKCalpha was the most implicated.  (+info)

Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens. (2/93)

The genes rdmB and rdmC of Streptomyces purpurascens encoding aclacinomycin modifying enzymes RdmB and RdmC were expressed in Streptomyces lividans TK24. In contrast to the earlier suggestion that RdmC may be an esterase that causes the removal of the carbomethoxy group from the 10 position of aclacinomycins, RdmC functions as an aclacinomycin methyl esterase and catalyzes the removal of the methoxy group from the C-15 position of aclacinomycin T producing 15-demethoxyaclacinomycin T. RdmB acts upon C-10 of 15-demethoxyaclacinomycin T and is able to remove the carboxylic group from the C-10 position. It functions also as an aclacinomycin-10-hydroxylase being able to add a hydroxyl group at the same, C-10 position in vitro. Aclacinomycin methyl esterase was purified to apparent homogeneity from S. lividans carrying the rdmC and aclacinomycin-10-hydroxylase as a glutathione S-transferase fusion construct from Escherichia coli carrying the rdmB gene, respectively. Aclacinomycin methyl esterase functions as a monomer and aclacinomycin-10-hydroxylase as a tetramer. Aclacinomycin methyl esterase has an exceptionally high temperature stability and has an apparent K(m) for aclacinomycin T of 15.5 microM. The introduction of rdmC and rdmB in a Streptomyces galilaeus mutant HO38 produced the same modifications of aclacinomycin T in vivo as aclacinomycin methyl esterase and aclacinomycin-10-hydroxylase in vitro.  (+info)

Molecular cloning and disruption of a novel gene encoding UDP-glucose: tetrahydrobiopterin alpha-glucosyltransferase in the cyanobacterium Synechococcus sp. PCC 7942. (3/93)

The gene encoding UDP-glucose:tetrahydrobiopterin alpha-glucosyltransferase (BGluT) was cloned from the genomic DNA of Synechococcus sp. PCC 7942. The encoded protein consisting of 359 amino acid residues was verified in vitro and in vivo to be responsible for the synthesis of tetrahydrobiopterin (BH4)-glucoside produced in the organism. The BGluT gene is the first cloned in pteridine glycosyltransferases and also a novel one cloned so far in UDP-glycosyltransferases. The mutant cells disrupted in the BGluT gene produced only aglycosidic BH4 at a level of 8.3% of the BH4-glucoside in wild type cells and exhibited half of the wild type growth in normal photoautotrophic conditions. These results suggest that the glucosylation of BH4 is required for the maintenance of the high cellular concentration of the compound, thereby supporting the normal growth of Synechococcus sp. PCC 7942.  (+info)

Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (4/93)

Keratin 8 and 18 (K8/18) are the major components of intermediate filament (IF) proteins of simple or single-layered epithelia. Recent data show that normal and malignant epithelial cells deficient in K8/18 are nearly 100 times more sensitive to tumor necrosis factor (TNF)-induced cell death. We have now identified human TNF receptor type 1 (TNFR1)-associated death domain protein (TRADD) to be the K18-interacting protein. Among IF proteins tested in two-hybrid systems, TRADD specifically bound K18 and K14, type I (acidic) keratins. The COOH-terminal region of TRADD interacted with the coil Ia of the rod domain of K18. Endogenous TRADD coimmunoprecipitated with K18, and colocalized with K8/18 filaments in human mammary epithelial cells. Overexpression of the NH2 terminus (amino acids 1-270) of K18 containing the TRADD-binding domain as well as overexpression of K8/18 in SW13 cells, which are devoid of keratins, rendered the cells more resistant to killing by TNF. We also showed that overexpressed NH2 termini of K18 and K8/18 were associated with endogenous TRADD in SW13 cells, resulting in the inhibition of caspase-8 activation. These results indicate that K18 may sequester TRADD to attenuate interactions between TRADD and activated TNFR1 and moderate TNF-induced apoptosis in simple epithelial cells.  (+info)

Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients. (5/93)

Proximal spinal muscular atrophy (SMA) is a common motor neuron disorder caused by mutation of the telomeric survival of motor neuron gene SMN1. The centromeric survival of motor neuron SMN2 gene is retained in all SMA patients but does not produce sufficient SMN protein to prevent the development of clinical symptoms. The SMN1 and SMN2 genes differ functionally by a single nucleotide change. This change affects the efficiency with which exon 7 is incorporated into the mRNA transcript. Thus, SMN2 produces less full-length mRNA and protein than SMN1. We have screened a library of compounds in order to identify ones that can alter the splicing pattern of the SMN2 gene. Here, we report that the compound aclarubicin increases the retention of exon 7 into the SMN2 transcript. We show that aclarubicin effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34. In type I fibroblasts, treatment resulted in an increase in SMN protein and gems to normal levels. Our results suggest that alteration of splicing pattern represents a new approach to modification of gene expression in disease treatment and demonstrate the feasibility of high throughput screens to detect compounds that affect the splicing pattern of a gene.  (+info)

Superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group. (6/93)

This study analyzed data on 35 infants with acute myeloid leukemia (AML) who were treated with intensive chemotherapy between 1995 and 1998 in Japan. The incidence of boys, younger age (< 6 months old), and hyperleukocytosis at onset was high in patients with the M4/M5 subtype (n = 23) in the French-American-British classification, compared with the non-M4/M5 subtype (n = 12). Thirteen (56%) and 16 (70%) patients with the M4/M5 subtype also showed 11q23 translocations and MLL gene rearrangements, respectively, whereas only one patient with the non-M4/M5 subtype had this rearrangement. All 35 patients were treated with the ANLL91 protocol consisting of etoposide, high-dose cytarabine, and anthracyclines. Overall survival and the event-free survival (EFS) rates at 3 years of all patients were 76% (95% confidence interval [CI], 61.3%-90.7%) and 72% (95% CI, 56.4%-87.9%), respectively. EFS showed no significant difference between 2 subgroups divided by age, gender, presence of the MLL gene rearrangements, and white blood cell count at onset; EFS in patients with the M4/M5 subtype tended to be better than those with the non-M4/M5 subtype. Although all 6 patients who underwent allogeneic stem cell transplantation (SCT) have been in complete remission, no benefit of SCT was confirmed. These findings suggest that the intensive chemotherapy with the ANLL91 protocol might have been responsible for the observed good outcome of infant AML, even without SCT. The presence of the MLL gene rearrangements or the age at onset had no impact on the outcome of infant AML.  (+info)

Induction of p16INK4a transcription and of cellular senescence by aclacinomycin-derivatives and cardiac glycosides. (7/93)

Stable transformants of Saos-2 cells that contain the luciferase reporter gene under the control of the human p16INK4a transcriptional regulatory region were established, and were used to identify growth-inhibiting substances from culture broths of actinomycetes and extracts of plants. Among the active substances so far identified were an aclacinomycin-derivative, cenerubin B, and a cardiac glycoside, periplocin. These substances inhibited growth of normal human fibroblasts, and induced senescent phenotypes including a flattened morphology and increased acidic beta-galactosidase activity, although the activities of their derivatives to induce p16CDKN2 and beta-galactosidase did not coincided with each other. These results suggest that the reporter system using the p16CDKN2 transcriptional regulatory region is a useful means for screening growth inhibiting substances that are potential anti-tumor agents.  (+info)

Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glycosylation patterns. (8/93)

In this study a set of Streptomyces galilaeus ATCC 31615 mutants was characterized, which are incapable of synthesizing some or all of the deoxyhexose sugars of aclacinomycin A. Complementation experiments with the the mutant strains H026, H038, H039, H054, H063, H065 and H075 were carried out with glycosylation genes previously derived from the wild-type S. galilaeus. Mutations in strains H038, H063 and H075 were complemented with single PCR-amplified genes. Furthermore, amplification and sequencing of the corresponding genes from the mutant strains revealed single point mutations in the sequences. First, in H038 a transition mutation in aknQ, encoding a putative dTDP-hexose 3-ketoreductase, causes an amino acid substitution from glycine to aspartate, suppressing the biosynthesis of both 2-deoxyfucose and rhodinose and thus leading to the accumulation of aclacinomycin T with rhodosamine as its only sugar. Second, in H063, which accumulates aklavinone without a sugar moiety, amino acid substitution occurs, with threonine being substituted by isoleucine in dTDP-glucose synthase, the first enzyme participating in deoxyhexose biosynthesis, encoded by aknY. Third, a nonsense mutation in aknP leads to truncated dTDP-hexose 3-dehydratase in H075, which is incapable of synthesizing rhodinose. In addition, mutants H054 and H065, which accumulate aclacinomycins without aminosugars, were complemented by a gene for an aminotransferase, aknZ. Characterization of the nature of the mutations adds to the usefulness and value of the mutants in the analysis of gene function and in the creation of novel compounds by combinatorial biosynthesis. Furthermore, these results strengthen the assignments of akn gene products and enlighten the biosynthetic pathway for deoxyhexoses.  (+info)

The effect of combinations of the anthracyclines aclarubicin and daunorubicin was investigated in a clonogenic assay using the human small cell lung cancer cell line OC-NYH and a multidrug-resistant (MDR) murine subline of Ehrlich ascites tumor (EHR2/DNR+). It was found that the cytotoxicity of daunorubicin in OC-NYH cells was antagonized by simultaneous exposure to nontoxic concentrations of aclarubicin. Coordinately, aclarubicin inhibited the formation of daunorubicin-induced protein-concealed DNA single-strand breaks and DNA-protein cross-links in OC-NYH cells when assayed by the alkaline elution technique. Aclarubicin had no influence on the accumulation of daunorubicin in these cells. In contrast, the accumulation of daunorubicin in EHR2/DNR+ cells was enhanced by more than 300% when the cells were simultaneously incubated with the MDR modulator verapamil, aclarubicin, or the two agents combined. Yet the cytotoxicity of daunorubicin was potentiated significantly only by verapamil. The ...
function: Involved in the biosynthesis of the trisaccharide moiety characteristic of the antitumor drug aclacinomycins. In the first reaction, AknK catalyzes the transfer of 2-deoxy-beta-L-fucose from the activated donor dTDP-2-deoxy-beta-L-fucose to the mono-glycosylated aclacinomycin T (rhodosaminyl aklavinone), forming the di-glycosylated aclacinomycin S (L-2-deoxyfucosyl-L-rhodosaminyl aklavinone). It can also catalyze the addition of an alternate dTDP-L-sugar, dTDP-L- daunosamine, to aclacinomycin T and the addition of 2-deoxy-beta-L- fucose to the mono-glycosylated aglycones (monoglycosylated anthracyclines) such as daunomycin (daunorubicin), adriamycin (doxorubicin) and idarubicin. In vitro, AknK also catalyzes the addition of a second L-2-deoxyfucosyl moiety from dTDP-2-deoxy-beta-L- fucose, albeit with reduced activity, to the natural disaccharide chain of aclacinomycin S to produce L-deoxyfucosyl-L-deoxyfucosyl-L- rhodosaminyl aklavinone (2-deoxy-alpha-D-fucosyl-aclacinomycin S), a ...
Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the NADPH-specific conversion of aklaviketone to yield aklavinone. It can also convert maggiemycin and 7-oxodaunomycinone to epsilon-rhodomycinone and daunomycinone, respectively.
The bHLH transcription factor ATOH7 (Math5) is crucial for developing retinal ganglion cell (RGC) fate. the developing sight as explained by immediate fluorescence (Fig. 1B). GFP expression Aclacinomycin A was observed by E12. 5 various and E13. 5 matching to the maximum time of reflection (Fig. 1C 1 contrary to expression which will diminishes following E14 Even so. 5 GFP expression remained to E18. 5 (Fig. 1E). This is most likely as a result of high steadiness of the H2B-GFP fusion healthy proteins. The stability allowed us to adhere to the fortune of was not a longer stated thereby featuring an opportunity to compare and contrast this pseudo-tracing method to lineage looking up studies that used even more conventional strategies (Brzezinski ain al. 2012 Yang ain al. the year 2003 P0 retinas showed strong and about equal numbers of GFP reflection in the ganglion cell Aclacinomycin A part and interior nuclear part and much sluggish expression inside the outer indivisible layer (Fig. 1F). The ...
Genome-wide analysis of H3.3 nucleosome turnover.(A) Experimental scheme to determine the turnover index. (B) Two-dimensional histogram of T24 and T48 for all H
17685523] Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. (J Am Chem Soc. , 2007 ...
Aclarubicin is one of the derivatives of anthracycline drugs exhibiting less side effects in comparison with the commonly used anthracyclines Generation - doxorubicin and daunorubicin. This article presents the current knowledge of the molecular mechanisms of the cytotoxic effect of the ACL, such as the effect on the activity of topoisomerase I and II, the processes of replication and transcription. Also discussed was the impact of the ACL with the cell membrane, drug transport through the membrane and the plasma membrane involved in the acquisition of multidrug resistance. ...
Synonyms for Acla in Free Thesaurus. Antonyms for Acla. 21 words related to antibody: active site, protein, autoantibody, precipitin, ABO antibodies, Rh antibody, antitoxin, agglutinin, Forssman antibody.... What are synonyms for Acla?
Vijendra Kumar (Laboratory Technician);. Summary of Research. Mammalian cells receive and process signals from a variety of extra-cellular stimuli those engage dedicated signaling pathways to elicit appropriate cellular responses. In physiological settings, however, a variety of different stimuli are often impinged upon a single cell simultaneously activating multiple signaling pathways; thereby generatingthe possibility for crosstalk between these apparently insulated cell-signaling pathways. Our research interest lies in exploring the interplay between these dedicated signaling pathways and understanding the implications of such interdependent regulations in physiology and patho-physiology.. In particular, the NF-kappaB signaling system has the remarkable capacity to process signals from a variety of extracellular as well as intracellular cues, those include pathogen derived substances, host-derived cytokines, cell-differentiating and developmental cues, reactive oxygen species or ...
Washington, D.C. - Following the announcement of new steps and updated CDC guidelines to ramp up testing and help schools reopen, ACLA President Julie Khani released the following statement:. Americans are eager to return to work and school, and all accurate and reliable tests have a role in getting us there. We applaud the Biden Administration for taking additional steps to ensure all communities have access to the full range of testing options available.. Clinical laboratories have introduced a range of new tests and techniques to meet widespread patient need, including the development of the at-home specimen collection kits, the expanded use of specimen pooling and multiplex testing, and the launch of serologic testing and novel RNA extraction methods. We remain focused on expanding access to accurate and reliable testing for the patients who are counting on us and stand ready to expand our support in local communities.. ###. The American Clinical Laboratory Association (ACLA) is the ...
The American Clinical Laboratory Association (ACLA) announced a new analysis today that shows clinical laboratories contribute $100 billion in overall economic output to the US economy.
مقدمه: با توجه به ارتباط بین دهان و دندان و بیماری‌های سیستمیک و نقش قطعی عفونت‌های دهان و دندان در فرآیندهای پاتولوژیک در نقاط دیگر بدن، هدف از مطالعه حاضر بررسی اثر درمان غیر جراحی پریودنتال بر سطح سرمی آنتی بادی ضد کاردیولیپین (aCLA) است که به طور بالقوه در پاتوژنز بیماری های قلبی عروقی در بیماران پریودنتال نقش دارد.مواد و روش: بیست داوطلب (11 زن و 9 مرد) با میانگین سنی 55/40 سال در این مطالعه شرکت کردند. پریودنتیت مزمن با معاینه کامل پریودنتال تشخیص داده شد. این معاینات شامل اندازه گیری عمق پاکت (PD) و از دست رفتن چسبندگی (AL)، همچنین شاخص پلاک (PI) و شاخص لثه ای (GI) بود
The genotoxicity of two new anthracycline antitumor antibiotics, aclacinomycin A and marcellomycin, which are potent cytostatic agents similar to Adriamycin and daunomycin, was investigated in various assays. In contrast to Adriamycin and daunomycin, both agents were devoid of mutagenic activity in the Salmonella-microsome assay as well as in a mammalian cell assay using V79 Chinese hamster cells. In primary rat hepatocytes, aclacinomycin A was active in inducing unscheduled DNA synthesis, whereas marcellomycin was not. After single i.v. doses of the 10% lethal dose, marcellomycin (15 mg/kg) did induce mammary tumors in female Sprague-Dawley rats, whereas aclacinomycin A (15 mg/kg) proved to be nontumorigenic. In conjunction with previous data, these results indicate that: (a) cytostatic and genotoxic properties of anthracyclines can be clearly separated; (b) alkylation of the primary amino group of their sugar moieties can abolish or greatly reduce mutagenic activity; and (c) poor correlations ...
Effects of the structural analogues, adriamycin (ADM), daunomycin (DNM), carminomycin (CMM), 4-demethoxydaunomycin (4D-DNM), pyrromycin (PYM), marcellomycin (MCM), and aclacinomycin (ACM) upon total cell RNA synthesis and the appearance of total RNA and poly(A)+-RNA in the cytoplasm of uninduced Friend erythroleukemia cells were investigated. The anthracyclines inhibited cellular RNA synthesis with IC50 values of 1-3 microM (ADM, DNM), 0.3-0.5 microM (CMM, 4D-DNM, PYM), and 0.06 microM (MCM, ACM). IC50 values for the appearance of total RNA in the cytoplasm were consistently 2-3 times lower than those for total cell RNA synthesis for each anthracycline. IC50 values for the inhibition of poly(A)+-RNA in the cytoplasm by ADM, DNM, and CMM were equivalent to those for total RNA synthesis. The values for MCM and ACM were 2-3 times higher than those for total RNA synthesis. The kinetic actions of drug-induced inhibition of poly(A)+-RNA appearance in the cytoplasm and inhibition of total RNA synthesis ...
BH-AC-AMP protocol: chemotherapy protocol consisting of N(4)-behenoyl-1-beta-arabinofuranosylcytosine, aclarubicin, 6-mercaptopurine & prednisolone
2322 Rayburn House Office Building. Introduction. Chairman Pitts, Ranking Member Pallone, and members of the Subcommittee, the American Clinical Laboratory Association (ACLA) is pleased to have this opportunity to testify at todays hearing, 21st Century Cures: Examining the Regulation of Laboratory- Developed Tests.. ACLA is a not-for-profit association representing the nations leading providers of clinical laboratory services, including local, regional, and national laboratories. Our diverse membership represents a broad array of clinical laboratories, includes large national independent labs, reference labs, esoteric labs, hospital labs, and nursing home laboratories. ACLA members are actively engaged in the creation and performance of innovative and much-needed Laboratory-Developed Tests (LDTs) that have helped to transform the standard of clinical care in this country and provide great hope for further improvements in the future.. ACLA and its member laboratories are committed to ...
Iranian Iranica Journal of Energy and Environment (IJEE) is an international scientific journal published by Babol Noshirvani University of Technology. The aim
The ACM India Council is an effort of ACM aimed at increasing the level and visibility of ACM activities across India. The ACM community in India is growing in membership, number of chapters, sponsored conferences and symposia.. The ACM India Council comprises a cross section of the computer science and information technology community committed to increasing the visibility and relevance of ACM in India. The council is focused on a wide range of ACM activities including:. ...
About ACM Publications. For more than 60 years, the best and brightest minds in computing have come to ACM to meet, share ideas, publish their work and change the world. ACM's publications are among the most respected and highly cited in the field because of their longstanding focus on quality and their ability to attract pioneering thought leaders from both academia and industry.. [Learn More about ACM Publications...] ...
This is a sample file for ACM large trim, single column journals, using acmart.cls v1.79 (2021/08/29). This template is provided by the ACM - please see the ...
acm之pku题目分类 对ACM有兴趣的同学们可以看看 DP: 1011 NTA 简单题 1013 Great Equipment 简单题 1024 Calendar Game 简单题 1027 Human Gene Functions 简单题 1037 Gridland
The new 802.11bf standard will turn Wi-Fi devices into object sensors: In three years or so, the Wi-Fi specification is scheduled to get an upgrade that will turn... Bruce Schneier ...
scrollLeft pobiera bądź ustawia liczbę pikseli, o którą zostanie przewinięta zawartość dokumentu. Kierunek przewijania odbywa się w lewo.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic-producing genus of actinobacteria, producing chemotherapy, antibacterial, antifungal, antiparasitic drugs, and immunosuppressants. Streptomyces isolates are typically initiated with the aerial hyphal formation from the mycelium. Streptomyces, yielded the medicines doxorubicin (Doxil), daunorubicin (DaunoXome), and streptozotocin (Zanosar). Doxorubicin is the precursor to valrubicin (Valstar), myocet, and pirarubicin. Daunorubicin is the precursor to idarubicin (Idamycin), epirubicin (Ellence), and zorubicin. Streptomyces is the original source of dactinomycin (Cosmegen), bleomycin (Blenoxane), pingyangmycin (Bleomycin A5), mitomycin C (Mutamycin), rebeccamycin, staurosporine (precursor to stauprimide and midostaurin), neothramycin, aclarubicin, tomaymycin, sibiromycin, and mazethramycin. Derivatives of ...
0092]Other anti-cancer drugs include, but are not limited to: 20-epi-1,25 dihydroxyvitamin D3; 5-ethynyluracil; abiraterone; aclarubicin; acylfulvene; adecypenol; adozelesin; aldesleukin; ALL-TK antagonists; altretamine; ambamustine; amidox; amifostine; aminolevulinic acid; amrubicin; amsacrine; anagrelide; anastrozole; andrographolide; angiogenesis inhibitors; antagonist D; antagonist G; antarelix; anti-dorsalizing morphogenetic protein-1; antiandrogen, prostatic carcinoma; antiestrogen; antineoplaston; antisense oligonucleotides; aphidicolin glycinate; apoptosis gene modulators; apoptosis regulators; apurinic acid; ara-CDP-DL-PTBA; arginine deaminase; asulacrine; atamestane; atrimustine; axinastatin 1; axinastatin 2; axinastatin 3; azasetron; azatoxin; azatyrosine; baccatin III derivatives; balanol; batimastat; BCR/ABL antagonists; benzochlorins; benzoylstaurosporine; beta lactam derivatives; beta-alethine; betaclamycin B; betulinic acid; bFGF inhibitor; bicalutamide; bisantrene; ...
Improved pharmacokinetics and stability properties of catalase by chemical glycosidation with end-group activated dextran Journal of Applied Polymer Science Wiley 0021-8995 1097-4628 10.1002/APP.25019
Lymphoblastic Lymphoma (LBL) - a very aggressive non-hodgkins lymphoma often occurring in younger patients. Intensive combination chemotherapy is standard treatment. 1. a diffuse lymphoma in children, with supradiaphragmatic distribution and T lymphocytes having convoluted nuclei; many patients develop acute lymphoblastic leukemia. Synonyms: lymphoblastoma ...
Next-day shipping cDNA ORF clones derived from ACLA_013420 Cytochrome P450 oxidoreductase, putative available at GenScript, starting from $99.00.
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Murine Mikrogliakulturen wurden mit Astrozyten-konditioniertem Medium (ACM) in einen deaktivierten Zustand überführt. Dies wurde anhand morphologischer (Grad der Ramifizierung) und immunologischer (Expression von Adhäsionsmolekülen) Parameter verifiziert. Durch den Einsatz von Makrophagen-koloniestimulierenden Faktor (M-CSF), Granulozyten/Makrophagen-koloniestimulierenden Faktor (GM-CSF), transformierenden Wachstumsfaktor beta (TGF-beta) und den gegen sie gerichteten Antikörpern wurde gezeigt, daß alle untersuchten Zytokine in unterschiedlichem Maße an der Deaktivierung der Mikrogliazellen durch ACM beteiligt sind. Außerdem wurde nach Stimulation mit ACM an murinen Mikrogliazellen eine transiente Hochregulation eines Kaliumauswärtsstromes beobachtet Das Auftreten dieses Kalium-stromes nach Inkubation der Mikrogliazellen mit ACM konnte auf die Wirkung von TGF-beta, welches im ACM enthalten ist, zurückgeführt werden. Der durch ACM in deaktivierter Mikroglia induzierte Kaliumkanal ...
ACM Case Studies document the conversations among leaders in the field about the interesting problems being addressed in the practice of computer science
CO2 anion has which of the characteristics? Bonds of unequal length (A) (C) (B) (D) sp2-hybridised carbon Same bond angles Resonance stabilisation
(KudoZ) English to Polish translation of Data buffer underrun error: błąd opróżnienia/niedopełnienia bufora danych [Computers: Software].
The electrical submersible pump, typically called an ESP, is an efficient and reliable artificial-lift method for lifting moderate to high volumes of fluids from wellbores. These volumes range from a low of 150 B/D to as much as 150,000 B/D (24 to 24,600 m 3 /d). Variable-speed controllers can extend this range significantly, both on the high and low side.. Quotation ...
Designers, developers, and researchers frequently use their own systems during design in order to test concepts, learn through actual usage, or find and fix software bugs. In fact, many would...
0048] Chemotherapeutic agents include, but are not limited to, the following sub-classes of compounds: Antineoplastic agents such as: Acivicin; Aclarubicin; Acodazole Hydrochloride; Acronine; Adozelesin; Adriamycin; Aldesleukin; Altretamine; Ambomycin; Ametantrone Acetate; Aminoglutethimide; Amsacrine; Anastrozole; Anthramycin; Asparaginase; Asperlin; Azacitidine; Azetepa; Azotomycin; Batimastat; Buniodepa; Bicalutamide; Bisantrene Hydrochloride; Bisnafide Dimesylate; Bizelesin; Bleomycin Sulfate; Brequinar Sodium; Bropirimine; Busulfan; Cactinomycin; Calusterone; Caracemide; Carbetimer; Carboplatin; Carmustine; Carubicin Hydrochloride; Carzelesin; Cedefingol; Chlorombucil; Cirolemycin; Cisplatin; Cladribine; Crisnatol Mesylate; Cyclophosphamide; Cytarabine; Dacarbazine; DACA (N-[2-(Dimethyl-amino)ethyl]acridine-4-carboxamide); Dactinomycin; Daunorubicin Hydrochloride; Daunomycin; Decitabine; Dexormaplatin; Dezaguanine; Dezaguanine Ifesylate; Diaziquone; Docetaxel; Doxorubicin; Doxorubicin ...
Schedule H is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
The icariin acts expand the capacities of the corpus cavernosum and its blood vessels, allowing more blood to flowresulting in a firmer, harder erection. Even the boss of his company dares to slander, is the advantage really so easy to take? Park Zhixie rubbed his stomach and walked to the window The past few days were really tiring Just as he sighed and prepared to adjust his mood to meet the next challenge, the phone rang Jiyeon is gone. Zheng Xiujing said angrily So Erectile Dysfunction Names let you watch Park Jiyan shouted Erectile aggressively Zheng Xiujing rolled her eyes directly, and some doubts appeared in her heart Kim Dysfunction Taehee showed his favor Names to Park Jiyeon on the first day he joined the company, there is a problem! Big problem Unless. With countless male enhancement supplements available on the market today it seems impossible to find the right one Sexual performance declines naturally as men age, which may contribute to feelings of inadequacy or embarrassment. ...
9305965] Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. (Biochemistry. , 1997 ...
Narangābād local information and maps. Narangābād is a populated place in Bangladesh (general), Bangladesh, Asia. Narangabad is also known as Nairangabad, Nairangābād.
You must RSVP for this event to enter the Disney Lot. Reservations must be made by 10AM PDT on Thursday, 16 October. All attendees must RSVP whether you walk, bicycle, skate, unicycle, drive, bus, fly or any other means of getting onto the Disney lot. Please bring a government-issued photo ID for access to the Disney lot. Everyone entering the facility must have ID. All LA ACM SIGGRAPH will be admitted free of charge. Non-members of LA ACM SIGGRAPH are admitted for $20.00. New LA ACM SIGGRAPH members who sign up on-site, and pay the $40 annual membership fee, do not have to pay the $20 admission fee. The chapter accepts checks, cash, or credit cards (Mastercard or Visa only) for all dues or fees.. ...
ACM SIGGRAPH is a thriving international organization. Everybody who shares ACM SIGGRAPHs love for computer graphics and interactive techniques is warmly invited to join ACM SIGGRAPH and attend SIGGRAPH or SIGGRAPH Asia.. Join Today!. ...
ACM SIGGRAPH is a thriving international organization. Everybody who shares ACM SIGGRAPHs love for computer graphics and interactive techniques is warmly invited to join ACM SIGGRAPH and attend SIGGRAPH or SIGGRAPH Asia.. Join Today!. ...
Dustin Lynch doesnt hide his feelings in his new candid video series. Watch the country stars reaction to not getting a nomination for the 2018 ACM awards.
The world was stunned by the first real look at Googles Project Glass. In a video released by the search giant, we got a a captivating look at how its glasses... ABC News ...
Zacna Budka to fotobudka idealna na wesele, imprezę oraz studniówkę! Z Zacną Budką wesele, impreza i studniówka nie będą nudne. Fotobudka gwarantuje świetną zabawę. Działamy w Pile, Złotowie, Chodzieży, Wałczu oraz Trzciance.
As Canadians are taking all necessary precautions to minimize the COVID-19 outbreak, Cooper Dental in full agreeance with Alberta Health Services and the Alberta Dental Association & College is implementing temporary closure of our dental clinics for all non-emergency treatment at this time. We will be available for emergency dental services and any inquires you may have. Please connect with us via email.. ...
to run your blog, however suppose you added a headline to maybe get peoples attention? I mean Ubuntu 7.10 a.k.a Gutsy Gibbon on Asus W3J - Kramfs Tech Chronicles is a little boring ...
Purchase Direct Microbial Conversion of Biomass to Advanced Biofuels - 1st Edition. Print Book & E-Book. ISBN 9780444595928, 9780444595898
İnsan bədən hissələri şəkillər adlar: bədən hissəsi adları, bacak hissələri, baş hissələri, üz parça adları, qol bədən hissələri, tam əl parçaları
K13524 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22] , (RefSeq) 4-aminobutyrate transaminase ...
Communications of the ACM is the monthly journal of the Association for Computing Machinery (ACM). It was established in 1958,[1] with Saul Rosen as its first managing editor. It is sent to all ACM members.[2][3] Articles are intended for readers with backgrounds in all areas of computer science and information systems. The focus is on the practical implications of advances in information technology and associated management issues; ACM also publishes a variety of more theoretical journals. ...
This page collects some information about stochastic systems courses offered at Caltech. This page was prepared in preparation for a faculty discussion on the current stochastic systems sequence (ACM/EE 116, ACM 216, ACM 217/EE 164). == Introduction == === Background === The current sequence of courses (ACM/EE 116, ACM 216, ACM 217/EE 164) were first offered in the 2005-06 academic year following discussions between Emmanuel Candes, Babak Hassibi, Jerry Marsden, Richard Murray and Houman Ohwadi about how to integrate some of the course offerings in ACM and EE, with an eye toward applications in CDS. EE 162 (Random Processes for Communication and Signal Processing) was eliminated and replaced by ACM/EE 116. There are three drivers for evaluating the course sequence at this time: * Its been a while since we set this up and it would be good to get together and see what we think about how its been going. * CDS is about to require ACM 116 as part of its PhD requirements (in place of CDS 140b) and ...
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Sept. 4 -- The ACM Europe Council will hold an international event from the 7th to the 8th of September in Barcelona. Hosted by the Barcelona
Od kilku tygodni meczy mnie taki oto blad : [bladff6ui.jpg] synatura : [szczegolyff3vx.jpg] Podobne bledy wyskakuja na IE oraz na Operze. Blad wyswietla sie bardzo czesto na stronach z filmikiem/teledyskiem otwie…
深圳孔雀B级人才,2006 年获得中国台湾国立交通大学,计算机信息与工程博士学位。自 2004 起有多年教职经验,2004 与 2008 年分别任中国台湾弘光科技大学资讯工程系讲师与系助理教授,2010 年起任哈尔滨工业大学(深圳)副教授。专业方面,自 1994 至 2002,有多年的研发经验,长期从事创新系统与机器学习算法研究工作。目前科研成果,发表文章65篇,其中有约20篇是高影响因子的 SCI 杂志或著名 ACM/IEEE 系列杂志,先后纵向与横向项目近14项,美国发明专利3项,国内发明专利20项,台湾发明专利24项 ...
09 F9 11 02 9D 74 E3 5B D8 41 56 C5 63 56 88 C0 This is everywhere today. Every major news site has this magic number in it. Digg.com had stories with more than 24.000 diggs (thats actually the first time I see that many). In case youve been in a cave for […]. ...
アプリ 熟女 登録不要出会い無料 - アプリ今回は 出会い系サイトはユーザーである十代から三十代まで幅広い女性にインタビューを行いました》 メンバーを紹介すると 既婚者Aに 三股中でギャルファッションに身を包むBアプリ 水商売のD ラストに 登録不要出会い無 ... ...
アプリ 熟女 登録不要出会い無料 - アプリ今回は 出会い系サイトはユーザーである十代から三十代まで幅広い女性にインタビューを行いました》 メンバーを紹介すると 既婚者Aに 三股中でギャルファッションに身を包むBアプリ 水商売のD ラストに 登録不要出会い無 ... ...
Early leads also included sodium orthovanadate and aclarubicin. Morpholino-type antisense oligonucleotides, with the same ... "Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients". Human Molecular ...
Anthracyclines (Aclarubicin · Daunorubicin · Doxorubicin · Epirubicin · Idarubicin · Amrubicin · Pirarubicin · Valrubicin · ...
This group includes novobiocin, merbarone, and aclarubicin, which also have other significant mechanisms of action. The ... Other clinically used drugs in the anthracycline group are pirarubicin, aclarubicin, and mitoxantrone. The mechanisms of ...
Dexrazoxane Novobiocin Merbarone Anthrycycline aclarubicin Dexrazoxane also known as ICRF-187 is currently the only clinically ... Common catalytic inhibitors that target TopII are dexrazoxane, novobiocin, merbarone and anthrycycline aclarubicin. ...
Since 2019, Jacques Neefjes is co-financing the production of a promising cancer drug, Aclarubicin, which disappeared from the ...
... aclarubicin, tomaymycin, sibiromycin, and mazethramycin. Derivatives of Streptomycetes isolate migrastatin, including ...
... aclarubicin MeSH D09.408.051.059.200 - daunorubicin MeSH D09.408.051.059.200.150 - carubicin MeSH D09.408.051.059.200.175 - ...
L01CX01 Trabectedin L01DA01 Dactinomycin L01DB01 Doxorubicin L01DB02 Daunorubicin L01DB03 Epirubicin L01DB04 Aclarubicin ...
... aclarubicin (INN) aclatonium napadisilate (INN) aclidinium bromide (USAN, INN) Aclovate acolbifene (USAN) acodazole (INN) ...
... aclarubicin MeSH D04.615.562.050.200 - daunorubicin MeSH D04.615.562.050.200.150 - carubicin MeSH D04.615.562.050.200.175 - ...
... (INN) or aclacinomycin A is an anthracycline drug that is used in the treatment of cancer. Soil bacteria ... October 1991). "Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: ... Streptomyces galilaeus can produce aclarubicin. It can induce histone eviction from chromatin upon intercalation. CID 451415 ...
Aclarubicin (INN) or aclacinomycin A is an anthracycline drug that is used in the treatment of cancer. Soil bacteria ... October 1991). "Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: ... Streptomyces galilaeus can produce aclarubicin. It can induce histone eviction from chromatin upon intercalation. CID 451415 ...
... aclarubicin, and daunorubicin. Int Arch Occup Environ Health. 1997; 70:378-384. ...
Aclarubicin - chemical Current Synonym true false 2770125018 Aclarubicin Current Synonym true false ...
Aclarubicin hydrochloride - chemical Current Synonym true false 2768773018 Aclarubicin hydrochloride Current Synonym true false ...
Dive into the research topics where Tomonari Kasai is active. These topic labels come from the works of this person. Together they form a unique fingerprint ...
The anthracycline variants Aclarubicin, Doxorubicinone and the newly developed Dimethyl-doxorubicin, which share anticancer ...
A Pilot Study of Aclarubicin for the Treatment of Retinal Vasculopathy With Cerebral Leukodystrophy (RVCL) ...
Transplantability and Sensitivity to Natural Killer Cells of Aclarubicin-resistant Murine Lymphoma. Sugimoto, Y., Hirakawa, Y. ...
Article: A phase II study of chidamide, cytarabine, aclarubicin, granulocyte colony-stimulating factor,... ...
Decitabine in combination with low-dose cytarabine, aclarubicin and G-CSF tends to improve prognosis in elderly patients with ...
Homestat Farm Ltd.s - Food Products gives you free access to a variety of quality food products and nutrition facts to facilitate your search for ready to eat and convenience foods and beverages.
Wang, I. K., Liu, C. H., Yen, T. H., Jeng, J. S., Hsu, S. P., Chen, C. H., Lien, L. M., Lin, R. T., Chen, A. C., Lin, H. J., Chi, H. Y., Lai, T. C., Sun, Y., Lee, S. P., Sung, S. F., Chen, P. L., Lee, J. T., Chiang, T. R., Lin, S. K., Muo, C. H., 及其他106Ma, H., Wen, C. P., Sung, F. C., Hsu, C. Y., Liu, C. H., Tsai, C. H., Huang, W. S., Lu, C. T., Tsai, T. C., Tseng, C. H., Lin, K. H., Shyn, W. C., Yang, Y. W., Liu, Y., Cho, D. Y., Chen, C. C., Jeng, J. S., Tang, S. C., Tsai, L. K., Yeh, S. J., Hsu, S. P., Chen, H. J., Chang, C. S., Kuo, H. C., Lee, L. H., Tsui, H. W., Tsou, J. C., Wang, Y. T., Tai, Y. C., Tsai, K. C., Chen, Y. W., Lu, K., Liliang, P. C., Tsai, Y. T., Liang, C. L., Wang, K. W., Wang, H. K., Chen, J. S., Chen, P-Y., Chye, C. L., Tzeng, W. J., Wu, P. H., Chen, C. H., Sung, P. S., Hsieh, H. C., Su, H. C., Chiu, H. C., Lien, L. M., Chen, W. H., Bai, C-H., Huang, T. H., Lau, C. I., Wu, Y. Y., Yeh, H. L., Chang, A., Lin, C. H., Yen, C. C., Lin, R. T., Chen, C. H., Khor, G. T., ...
aciclovir, aclarubicin, cefepime, cytarabine, famotidine, fluconazole, granisetron, tazobactam・piperacillin, vancomycin. 80. 上肢 ... aciclovir, aclarubicin, cefepime, cytarabine, famotidine, fluconazole, granisetron, tazobactam・piperacillin, vancomycin. 80. 低 ... aciclovir, aclarubicin, cefepime, cytarabine, famotidine, fluconazole, granisetron, tazobactam・piperacillin, vancomycin. 80. 好中 ... aciclovir, aclarubicin, cefepime, cytarabine, famotidine, fluconazole, granisetron, tazobactam・piperacillin, vancomycin. 80. 脱水 ...
This group includes novobiocin, merbarone, and aclarubicin, which also have other significant mechanisms of action.[56] ... Other clinically used drugs in the anthracyline group are pirarubicin, aclarubicin, and mitoxantrone. The mechanisms of ...
A new survey reveals that an increasing number of Britons are replacing TV dinners with PC dinners.
... aclarubicin, zinostatin, vincristine, vindesine, vinblastine, vinorelbine, paclitaxel, docetaxel, irinotecan, irinotecan active ... aclarubicin, zinostatin, vincristine, vindesine, vinblastine, vinorelbine, paclitaxel, docetaxel, irinotecan, irinotecan active ...
aciclovir, aclarubicin, cefepime, cytarabine, famotidine, fluconazole, granisetron, tazobactam・piperacillin, vancomycin. 80. 上肢 ... aciclovir, aclarubicin, cefepime, cytarabine, famotidine, fluconazole, granisetron, tazobactam・piperacillin, vancomycin. 80. 低 ... aciclovir, aclarubicin, cefepime, cytarabine, famotidine, fluconazole, granisetron, tazobactam・piperacillin, vancomycin. 80. 好中 ... aciclovir, aclarubicin, cefepime, cytarabine, famotidine, fluconazole, granisetron, tazobactam・piperacillin, vancomycin. 80. 脱水 ...
Aclarubicin, which belongs to the anthracycline family and inhibits cell proliferation by inhibiting topoisomerase, is widely ... Macrophages were pretreated with DMSO as the negative control for aclarubicin.. Supporting Figure S6. Expression of CD81 and ... For the treatment of FL, aclarubicin inhibits DNA replication in cells and is currently used as a standard chemotherapy for ... With the presence of aclarubicin in cultured medium (2.7 μg/ml), Western blotting revealed obvious higher levels of FasL and ...
A Pilot Study of Aclarubicin for the Treatment of Retinal Vasculopathy With Cerebral Leukodystrophy (RVCL) ...
1996 [Low-dose cytosine arabinoside and aclarubicin in combination with granulocyte colony-stimulating factor for the treatment ...
We are writing to notify visitors that the QTdrugs lists were revised on May 20, 2018 and aclarubicin, amsacrine, memantine, ...
Acipimox Acitazanolast Acitretin Aclarubicin Aclarubicin hydrochloride Aclatonium napadisilate Aclidinium bromide Aclonifen 7- ...
Aclarubicin 20 mg Injection Vial @ US $52.3125. - Acyclovir 200mg Tablet (Brand ZOVIRAX, GlaxoSmithKilne) @ US $0.5664. - ...
Aclarubicin *Alogliptin View All. FDA Approved Drugs. *Ado-Trastuzumab Emtansine *Alogliptin And Metformin ...
Online resource for healthcare professionals, providing information, news & support relating to AML
Aclarubicin (Aclacinon). *All-trans retinoic acid (ATRA). *Azacitidine (Vidaza). *Azacitidine oral (Onureg) ...
Treosulfan, sold under the brand name Trecondi, is a medication given to people before they have a bone marrow transplant from a donor known as allogeneic hematopoietic stem cell transplantation. It is used as a conditioning treatment to clear the bone marrow and make room for the transplanted bone marrow cells, which can then produce healthy blood cells.[3][4] It is used together with another medicine called fludarabine in adults and children from one month of age with blood cancers as well as in adults with other severe disorders requiring a bone marrow transplant.[3] It belongs to the family of drugs called alkylating agents.[3] In the body, treosulfan is converted into other compounds called epoxides which kill cells, especially cells that develop rapidly such as bone marrow cells, by attaching to their DNA while they are dividing.[3] The most common side effects in adults and children are infections, nausea (feeling sick), stomatitis (inflammation of the lining of the mouth), vomiting, ...
Phase II evaluation of aclarubicin in advanced breast cancer: a Southeastern Cancer Study Group trial. ... Phase II evaluation of aclarubicin in lung cancer: a Southeastern Cancer Study Group Trial. ...
  • Aclarubicin (INN) or aclacinomycin A is an anthracycline drug that is used in the treatment of cancer. (wikipedia.org)
  • MDS: decitabine, cytarabine, aclarubicin, and granulocyte colony-stimulating factor) with HLA-mismatched donor CD3+ allo-TLI 24 hours after each course. (hematologyadvisor.com)
  • Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). (icr.ac.uk)
  • Positively charged doxorubicin (DOX) and non-positively charged anthracyclines, aclarubicin (ACR) and morpholino-carminomycin (KRN 8602), have been investigated with respect to pharmacological parameters, cytotoxicity, DNA damage and repair in DOX-sensitive and -resistant murine and human cells. (elsevier.com)
  • Friend leukemia cells (FLC) resistant to high concentrations of doxorubicin (DOX-RFLC3) or daunorubicin (DNR-RFLC3) (1771 and 1543 fold resistance respectively) express less than 10 fold resistance to aclarubicin (ACR). (elsevier.com)
  • Three other compounds, aclarubicin, doxorubicin and mitoxantrone, showed some antifungal activity against C. glabrata and C. neoformans with MIC(50) values in the mid micromolar range. (uea.ac.uk)
  • All of the agents tested were potent in inducing micronuclei in human lymphoblastoid TK6 cells, with significant increases seen at low micromolar, and in the cases of aclarubicin and etoposide, at low nanomolar concentrations. (nih.gov)