Acinetobacter Infections: Infections with bacteria of the genus ACINETOBACTER.Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.Acinetobacter baumannii: A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.Drug Resistance, Multiple, Bacterial: The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Acinetobacter calcoaceticus: A species of gram-negative, aerobic bacteria found in soil and water. Although considered to be normally nonpathogenic, this bacterium is a causative agent of nosocomial infections, particularly in debilitated individuals.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Cross Infection: Any infection which a patient contracts in a health-care institution.Carbapenems: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.Colistin: Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).beta-Lactamases: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.beta-Lactam Resistance: Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
(1/737) Acinetobacter bacteremia in Hong Kong: prospective study and review.

The epidemiological characteristics of 18 patients with acinetobacter bacteremia were analyzed. Patients (mean age, 55.5 years) developed bacteremia after an average of 14.1 days of hospitalization. Fifteen of 16 patients survived bacteremia caused by Acinetobacter baumannii. Cultures of blood from the remaining two patients yielded Acinetobacter lwoffii. Most patients (78%) resided in the general ward, while four patients (22%) were under intensive care. Genotyping by arbitrarily primed polymerase chain reaction analysis and the temporal sequence of isolation were more useful than phenotyping by antimicrobial susceptibility in the determination of the source of bacteremia, and the intravascular catheter was the leading infection source (39% of cases). The possibility of an association of glucose with the pathogenesis of acinetobacter infection was raised.  (+info)

(2/737) Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case-control study of adult burn patients.

Risk factors for Acinetobacter baumannii bloodstream infection (BSI) were studied in patients with severe thermal injury in a burn intensive care unit where A. baumannii was endemic. Of 367 patients hospitalized for severe thermal injury during the study period, 29 patients with nosocomial A. baumannii BSI were identified (attack rate, 7.9%). Cases were compared with 58 matched controls without A. baumannii BSI. The overall mortality rate was 31% among cases and 14% among controls; only two deaths (7%) were considered directly related to A. baumannii BSI. Molecular typing of A. baumannii blood isolates by means of randomly amplified polymorphic DNA analysis and pulsed-field gel electrophoresis revealed the presence of three different strain types. Multivariate analysis showed that female gender (P = .027), total body surface area burn of > 50% (P = .016), prior nosocomial colonization with A. baumannii at a distant site (P = .0002), and use of hydrotherapy (P = .037) were independently associated with the acquisition of A. baumannii BSI in burn patients. These data underscore the need for effective infection control measures for this emerging nosocomial problem.  (+info)

(3/737) Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii.

From March 1995 to March 1997, sulbactam was prospectively evaluated in patients with non-life-threatening multiresistant Acinetobacter baumannii infections. During this period, 47 patients were treated with sulbactam; of them, five were excluded because they had received < or =48 h of sulbactam therapy. A total of 42 patients, 27 males and 15 females with a mean age of 60+/-15 years, were finally evaluated. Infections were as follows: surgical wound, 19; tracheobronchitis, 12; urinary tract, 7; catheter-related bacteraemia, 2; and pneumonia, 2. Eighteen patients received intravenous sulbactam alone (1 g every 8 h) and 24 patients received intravenous sulbactam/ampicillin (1 g:2 g every 8 h) with no major adverse effects. Of the 42 patients, 39 improved or were cured and showed A. baumannii eradication and one patient had persistence of wound infection after 8 days of sulbactam/ampicillin requiring surgical debridement. Two patients died after 3 days of therapy (one of the deaths was attributable to A. baumannii infection). The in-vitro activity of the sulbactam/ampicillin combination was by virtue of the antimicrobial activity exhibited by sulbactam. Killing curves showed that sulbactam was bacteriostatic; no synergy was observed between ampicillin and sulbactam. Our results indicate that sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem.  (+info)

(4/737) Identification of Acinetobacter baumannii strains with monoclonal antibodies against the O antigens of their lipopolysaccharides.

Despite the emergence of Acinetobacter baumannii strains as nosocomial pathogens, simple methods for their phenotypic identification are still unavailable. Murine monoclonal antibodies specific for the O-polysaccharide moiety of the lipopolysaccharide (LPS) of two A. baumannii strains were obtained after immunization with heat-killed bacteria. The monoclonal antibodies were characterized by enzyme immunoassay and by Western and dot blot analyses and were investigated for their potential use for the identification of A. baumannii strains. The antibodies reacted with 46 of the 80 A. baumannii clinical isolates that were investigated, and reactivity was observed with 11 of 14 strains which were isolated during outbreaks in different northwestern European cities; no reactivity was observed with Acinetobacter strains of other genomic species, including the closely related genomic species 1 (Acinetobacter calcoaceticus), 3, and 13 sensu Tjernberg and Ursing, or with other gram-negative bacterial strains. The results show that O-antigen-specific monoclonal antibodies such as the ones described are convenient reagents which can be used to identify Acinetobacter strains in clinical and research laboratories.  (+info)

(5/737) Some immunological properties of lipopolysaccharide from Acinetobacter baumannii.

Acinetobacter baumannii, mainly biotype 9, is an important nosocomial opportunist pathogen in Chile and other countries. The biological basis of its virulence and prevalence is still unknown. As lipopolysaccharide (LPS) is often associated with virulence, some biological properties of purified LPS from seven nosocomial isolates, comprising four isolates of A. baumannii biotype 9, two isolates of biotype 8 and one isolate of biotype 1, were investigated. LPS was extracted and purified from each isolate by the hot phenol-water method, and its ability to elicit a mitogenic response and to induce the synthesis of a tumour necrosis factor (TNF-alpha) in mouse spleen cells was determined. Activity was evaluated in vivo by determining the splenic index in comparison with LPS from Salmonella Typhimurium. All seven LPS samples were mitogenic on the basis of cellular proliferation experiments and six induced synthesis of TNF-alpha. Similar results were obtained in in-vivo experiments in which LPS induced spleen cell growth, as shown by determination of the splenic index. These results suggest that the LPS of A. baumannii might contribute to the pathogenic properties of this species.  (+info)

(6/737) Use of a murine O-antigen-specific monoclonal antibody to identify Acinetobacter strains of unnamed genomic species 13 Sensu Tjernberg and Ursing.

A monoclonal antibody against the O-antigenic polysaccharide chain of the lipopolysaccharide (LPS) of Acinetobacter strains belonging to the unnamed genomic species 13 Sensu Tjernberg and Ursing (13TU) was obtained after immunization of BALB/c mice with heat-killed bacteria and was characterized by enzyme immunoassay and Western blot analysis, by use of LPS and proteinase K-treated bacterial lysates, analyses in which the antibody was shown to be highly specific for the homologous antigen. In addition, when tested in dot and Western blots, reactivity was observed with 9 of 18 Acinetobacter strains of genomic species 13TU which had been isolated in Germany and Denmark; no reactivity was observed with strains of other genomic species, including the closely related genomic groups 1 (A. calcoaceticus), 2 (A. baumannii), and 3 (unnamed), or with other gram-negative bacteria. The antibody described here represents a convenient reagent for the simple, economical, and accurate differentiation of clinical isolates of genomic species 13TU from other Acinetobacter strains. Although the antibody does not identify all isolates of this genomic group, it is evident that it will be a useful reagent in the development of a serotyping scheme for clinical laboratories.  (+info)

(7/737) Genotypic and phenotypic similarity of multiresistant Acinetobacter baumannii isolates in the Czech Republic.

The diversity of 103 clinical isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex obtained between 1991 and 1997 from 17 Czech hospitals was studied by ribotyping, biotyping, plasmid profiling and antibiotic susceptibility testing. According to the EcoRI ribotypes, all but one of these isolates were identified to the DNA group level: 77 isolates were allocated to DNA group 2 (A. baumannii), 14 to DNA group 3, 10 to DNA group 13 sensu Tjernberg and Ursing and one to DNA group 1 (A. calcoaceticus). In total, 50 different EcoRI ribotypes and 10 biotypes were observed. Plasmids were found in 92% of the isolates and a high variability in plasmid profiles was found in isolates of the same DNA group. The combination of typing profiles allowed two predominant groups (termed A and B) to be distinguished among the A. baumannii isolates (37 and eight isolates, respectively) that shared a specific ribotype and were highly similar in other properties. These two groups comprised both sporadic and outbreak isolates and were found in most localities. Group A and B isolates were markedly more resistant to antibiotics than most of the remaining isolates, thus representing 85% of all multiresistant isolates. The features of groups A and B corresponded to those of two epidemic clones identified recently among hospital strains in north-western Europe.  (+info)

(8/737) In vivo efficacies of combinations of beta-lactams, beta-lactamase inhibitors, and rifampin against Acinetobacter baumannii in a mouse pneumonia model.

The effects of various regimens containing combinations of beta-lactams, beta-lactam inhibitor(s), and rifampin were assessed in a recently described mouse model of Acinetobacter baumannii pneumonia (M. L. Joly-Guillou, M. Wolff, J. J. Pocidalo, F. Walker, and C. Carbon, Antimicrob. Agents Chemother. 41:345-351, 1997). Two aspects of the therapeutic response were studied: the kinetics of the bactericidal effect (treatment was initiated 3 h after intratracheal inoculation, and bacterial counts were determined over a 24-h period) and survival (treatment was initiated 8 h after inoculation, and the cumulative mortality rate was assessed on day 5). Two clinical strains were used: a cephalosporinase-producing strain (SAN-94040) and a multiresistant strain (RCH-69). For SAN-94040 and RCH-69, MICs and MBCs (milligrams per liter) were as follows: ticarcillin, 32, 64, 256, and >256, respectively; ticarcillin-clavulanate, 32, 64, and 512, and >512, respectively; imipenem, 0.5, 0.5, 8, and 32, respectively; sulbactam, 0.5, 0.5, 8, and 8, respectively; and rifampin, 8, 8, 4, and 4, respectively. Against SAN-94040, four regimens, i.e., imipenem, sulbactam, imipenem-rifampin, and ticarcillin-clavulanate (at a 25/1 ratio)-sulbactam produced a true bactericidal effect (>/=3-log10 reduction of CFU/g of lung). The best survival rate (i.e., 93%) was obtained with the combination of ticarcillin-clavulanate-sulbactam, and regimens containing rifampin provided a survival rate of >/=65%. Against RCH-69, only regimens containing rifampin and the combination of imipenem-sulbactam had a true bactericidal effect. The best survival rates (>/=80%) were obtained with regimens containing rifampin and sulbactam. These results suggest that nonclassical combinations of beta-lactams, beta-lactamase inhibitors, and rifampin should be considered for the treatment of nosocomial pneumonia due to A. baumannii.  (+info)

*  Acinetobacter calcoaceticus
"Acinetobacter baylyi as a Pathogen for Opportunistic Infection". Journal of Clinical Microbiology. 46 (9): 2938-2944. doi: ... Acinetobacter calcoaceticus is a bacterial species of the genus Acinetobacter. It is a nonmotile, gram negative coccobacillus. ... Acinetobacter calcoaceticus on www.ncbi.nlm.nih.gov Type strain of Acinetobacter calcoaceticus at BacDive - the Bacterial ... To identify other Acinetobacter species genotyping is required. A. calcoaceticus is a soil bacterium. It has been shown to be ...
*  Acinetobacter
... and cannot be used to differentiate Acinetobacter from other common causes of infection. Most strains of Acinetobacter, except ... Acinetobacter species are a key source of infection in debilitated patients in the hospital, in particular the species ... Acinetobacter is frequently isolated in nosocomial infections, and is especially prevalent in intensive care units, where both ... Visca P, Seifert H, Towner KJ (December 2011). "Acinetobacter infection--an emerging threat to human health". IUBMB Life. 63 ( ...
*  Beta-lactamase
CTX-M-15-positive E. coli are a cause of community-acquired urinary infections in the UK, and tend to be resistant to all oral ... PER-1 is also common in multiresistant acinetobacter species in Korea and Turkey. Some of these enzymes are found in ... For infections caused by ESBL-producing Escherichia coli or Klebsiella species, treatment with imipenem or meropenem has been ... OXA carbapenemases hydrolyse carbapenems very slowly in vitro, and the high MICs seen for some Acinetobacter hosts (>64 mg/L) ...
*  Acinetobacter junii
"Clinical characteristics of patients with Acinetobacter junii infection". Journal of Microbiology, Immunology, and Infection = ... nov., Acinetobacter haemolyticus sp. nov., Acinetobacter johnsonii sp. nov., and Acinetobacter junii sp. nov. and Emended ... Acinetobacter junii at the Encyclopedia of Life Type strain of Acinetobacter junii at BacDive - the Bacterial Diversity ... Bouvet, P. J. M.; Grimont, P. A. D. (1986). "Taxonomy of the Genus Acinetobacter with the Recognition of Acinetobacter ...
*  Acinetobacter lwoffii
Rathinavelu, S; Zavros, Y; Merchant, JL (June 2003). "Acinetobacter lwoffii infection and gastritis". Microbes and infection / ... It can cause infections in human hosts, particularly catheter-associated infections in immunocompromised patients. It has also ... Acinetobacter lwoffii, formerly known as Mima polymorpha or Acinetobacter calcoaceticus var. lwoffii, is a non-fermentative ... Type strain of Acinetobacter lwoffii at BacDive - the Bacterial Diversity Metadatabase. ...
*  Drug of last resort
Used to treat XDR Acinetobacter baumannii infections. Tolcapone - used in patients with Parkinson's disease who are not ... used as drug of last resort for a variety of different bacterial infections. Clomethiazole - a sedative/hypnotic agent used in ... its usefulness only as an injectable and potency in treatment of infection with multiple drug-resistant organisms has caused a ...
*  Air ioniser
... airborne acinetobacter infections in a ward were eliminated by the installation of a negative air ioniser-the infection rate ... Air ionisers have been used to eliminate the occurrence of air-borne bacterial infections and to reduce static electricity ... The frequency of nosocomial infections in British hospitals prompted the National Health Service (NHS) to research the ... McDowell, Natasha (3 January 2003). "Air ionisers wipe out hospital infections". The New Scientist (Daily news). Retrieved 24 ...
*  Colistin
Use of colistin to treat Acinetobacter baumannii infections has led to the development of resistant bacterial strains. which ... Towner K J (2008). "Molecular Basis of Antibiotic Resistance in Acinetobacter spp.". Acinetobacter Molecular Biology. www. ... and it has come into recent use for treating multidrug-resistant Acinetobacter infection, although resistant forms have been ... "Colistin and rifampicin in the treatment of nosocomial infections from multiresistant Acinetobacter baumannii". Journal of ...
*  List of antibiotic resistant bacteria
Almost half of hospital patients who get bloodstream CRE infections die from the infection. Acinetobacter is a gram-negative ... Infections are most frequent in people who have had recent medical and/or antibiotic treatment. C. difficile infections ... Associated with these infections were an estimated 15,000 deaths. The CDC estimates that C. difficile infection costs could ... Centers for Disease Control Prevention (CDC). (2004). "Acinetobacter baumannii infections among patients at military medical ...
*  Carbapenem
Infections caused by the non-fermenting gram-negative bacteria Pseudomonas aeruginosa and Acinetobacter baumanni are most ... Rice LB (2006). "Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter ... and meropenem are recommended for high-risk community-acquired abdominal infections and for abdominal infections that are ... "Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection ...
*  Acinetobacter ursingii
"Blood stream infections caused by Acinetobacter ursingii in an obstetrics ward". Infection, Genetics and Evolution. 11 (1): 52- ... "Acinetobacter ursingii sp. nov. and Acinetobacter schindleri sp. nov., isolated from human clinical specimens". International ... and antimicrobial susceptibilities of Acinetobacter ursingii and Acinetobacter schindleri, two frequently misidentified ... Acinetobacter ursingii is a species of potentially pathogenic bacteria. Its type strain is LUH 3792T (= NIPH 137T = LMG 19575T ...
*  Gram-negative bacteria
... associated with hospital-acquired infections include Acinetobacter baumannii, which cause bacteremia, ... It has also been studied in gram-negative species found in soil such as Pseudomonas stutzeri, Acinetobacter baylyi, and gram- ...
*  Ventilator-associated pneumonia
Risk factors for infection with an MDR strain include ventilation for more than five days, recent hospitalization (last 90 days ... It is often resistant to a wide array of antibiotics but is usually sensitive to co-trimoxazole Acinetobacter are becoming more ... Even in cases with positive blood cultures, the bacteremia may be from a source other than the lung infection. Prevention of ... Ventilator-associated pneumonia is a type of lung infection that occurs in people who are on mechanical ventilation breathing ...
*  Naval Medical Research Unit Two
... research into pathogens infecting combat wounds resulting in the first descriptions of acinetobacter baumannii infection in ... reflecting its focus on tropical infections of interest to the military such as malaria and Dengue fever. In 1947 NAMRU-2 ...
*  Acinetobacter soli
... can cause bloodstream infection in neonates. LPSN bacterio.net Straininfo of Acinetobacter soli Dongyou Liu ... "Acinetobacter soli as a Cause of Bloodstream Infection in a Neonatal Intensive Care Unit". Journal of Clinical Microbiology. 49 ... Kim, D.; Baik, K. S.; Kim, M. S.; Park, S. C.; Kim, S. S.; Rhee, M. S.; Kwak, Y. S.; Seong, C. N. (2008). "Acinetobacter soli ... Acinetobacter soli is a Gram-negative, catalase-positive, oxidase-negative, strictly aerobic rod-shaped, nonmotile bacterium ...
*  Doxycycline
... infections Shigella species infections Acinetobacter species (formerly Mima species and Herellea species) infections ... doxycycline may be used to treat these infections caused by Gram-positive bacteria: Upper respiratory infections caused by ... doxycycline may be used to treat these infections caused by Gram-negative bacteria: Escherichia coli infections Enterobacter ... including methicillin-resistant Staphylococcus aureus infections Anthrax caused by Bacillus anthracis infection When penicillin ...
*  Minocycline
It may be used to treat certain strains of MRSA infection and a disease caused by drug resistant Acinetobacter. Both ... Urinary tract infections, rectal infections, and infections of the cervix caused by certain microbes Increase in sebaceous ... Minocycline is also used for other skin infections such as MRSA as well as Lyme disease, as the one pill twice daily 100 mg ... Rogers RL, Perkins J (September 2006). "Skin and soft tissue infections". Prim. Care. 33 (3): 697-710. doi:10.1016/j.pop. ...
*  Coppy Laws
"Repeated airborne infections of the bacteria acinetobacter in an intensive care ward have been eliminated by the installation ... "Air ionisers wipe out hospital infections - 03 January 2003". New Scientist. 3 January 2003. Retrieved 23 February 2014. "For ...
*  Acinetobacter pittii
They can cause infection in debilitated patients. DNA-DNA hybridization studies have been used to identify DNA groups (genomic ... formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Acinetobacter genomic species 13TU ... "Acinetobacter pittii and Acinetobacter nosocomialis among clinical isolates of the Acinetobacter calcoaceticus-baumannii ... characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii ...
*  Aminoglycoside
... complicated intraabdominal infections, complicated urinary tract infections, and nosocomial respiratory tract infections. ... Acinetobacter, and Enterobacter. In addition, some Mycobacteria, including the bacteria that cause tuberculosis, are ... Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more ... In the past, the aminoglycosides have been used in conjunction with beta-lactam antibiotics in streptococcal infections for ...
*  Gram-negative toe web infection
Gram-negative is mixed bacterial infection with the following organisms: Moraxella Alcaligenes Acinetobacter Pseudomonas ... Gram-negative toe web infection is a relatively common infection. It is commonly found on people who are engaged in athletic ... ISBN 0-7216-2921-0. "Gram-Negative Toe Web Infection". WebMD LLC. Retrieved 10 January 2013. "Gram-Negative Toe Web Infection: ... Gram-negative toe web infection is a cutaneous condition that often begins with dermatophytosis. ...
*  Non-fermenter
... has great relevance in the diagnosis of bacterial infections. Acinetobacter Bordetella Burkholderia Legionella Moraxella ...
*  List of MeSH codes (C01)
... acinetobacter infections MeSH C01.252.400.610 --- mycoplasmatales infections MeSH C01.252.400.610.610 --- mycoplasma infections ... bacteroides infections MeSH C01.252.400.126 --- bartonellaceae infections MeSH C01.252.400.126.100 --- bartonella infections ... bordetella infections MeSH C01.252.400.143.740 --- whooping cough MeSH C01.252.400.155 --- borrelia infections MeSH C01.252. ... proteus infections MeSH C01.252.400.310.821 --- salmonella infections MeSH C01.252.400.310.821.438 --- paratyphoid fever MeSH ...
*  Arbekacin
... for multidrug-resistant Gram-negative bacterial infections such as multidrug-resistant Pseudomonas aeruginosa and Acinetobacter ... It is primarily used for the treatment of infections caused by multi-resistant bacteria including methicillin-resistant ... Matsumoto T (2014). "Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus ...
*  Antibiotic misuse
... enterococcus and acinetobacter) can develop resistance to multiple antibiotics and cause life-threatening infections. ... If there is a diagnosis of bacterial infection, then antibiotics may be used. When children with ear tubes get ear infections, ... Antibiotics have no effect on viral infections such as the common cold. They are also ineffective against sore throats, which ... The use of topical antibiotics to treat surgical wounds does not reduce infection rates in comparison with non-antibiotic ...
*  New Delhi metallo-beta-lactamase 1
In May 2010, a case of infection with E. coli expressing NDM-1 was reported in Coventry in the United Kingdom. The patient was ... In July 2010, a team in New Delhi reported a cluster of three cases of Acinetobacter baumannii bearing blaNDM-1 that were found ... The infection was identified as a carbapenem-resistant Klebsiella pneumoniae strain bearing the novel gene blaNDM-1. The ... in December 2009 in a Swedish national who fell ill with an antibiotic-resistant bacterial infection that he acquired in India ...
*  Amikacin
This includes joint infections, intraabdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is ... Acinetobacter, Enterobacter, E. coli, Proteus, Klebsiella, and Serratia. The only Gram-positive bacteria that amikacin strongly ... Rhodococcus equi, which causes an infection resembling tuberculosis Respiratory tract infections, including as an adjunct to ... is used to treat subcutaneous infections that are caused by Staphylococcus. For infections in the limbs or joints, it is often ...
Mouse Models of Acinetobacter baumannii Infection - Current Protocols  Mouse Models of Acinetobacter baumannii Infection - Current Protocols
... the two most common manifestations of clinical infections with this pathogen ... This unit describes basic protocols for infecting mice through intranasal and intraperitoneal routes with Acinetobacter ... tissue infection models for the study of Acinetobacter baumannii biology. Infection and Immunity, 76(8), 3577-3586. doi: ... Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice. Infection ...
more infohttp://www.currentprotocols.com/WileyCDA/CPUnit/refId-mc06g03.html?quicktabs_cp=abstract
Increasing trends of Acinetobacter Baumannii infections in Emilia-Romagna, Italy | BMC Proceedings | Full Text  Increasing trends of Acinetobacter Baumannii infections in Emilia-Romagna, Italy | BMC Proceedings | Full Text
The temporal trends of A. baumannii infections are driven by carbapenem-resistant strains. A regional-wide outbreak of ... Public HealthSurveillance SystemTemporal TrendAcinetobacter BaumanniiRespiratory Sample. Introduction / objectives. Estimation ... of occurrence of Acinetobacter baumannii isolates from the antimicrobial surveillance system of Emilia-Romagna, Italy, 2005- ... carbapenem-resistant A. baumannii infections involving 4 hospital trust was observed in Emilia-Romagna in 2009. ...
more infohttps://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-5-S6-P292
Antibiotics  | Free Full-Text | Virulence of Acinetobacter baumannii Exhibiting Phenotypic Heterogeneous Growth against...  Antibiotics | Free Full-Text | Virulence of Acinetobacter baumannii Exhibiting Phenotypic Heterogeneous Growth against...
The meropenem treatment outcome was similar in infections caused by the clinical and the heterogeneous isolates, irrespective ... baumannii isolates grown heterogeneously in the presence of meropenem and their virulence evaluated in experimental infections ... Acinetobacter baumannii may exhibit phenotypic heterogeneous growth under exposure to antibiotics. We investigated the in vitro ... isolates and the therapeutic efficacy of three meropenem dosing schemes was evaluated in a neutropenic murine thigh infection ...
more infohttp://www.mdpi.com/2079-6382/2/1/73/notes
Molecular analysis of Acinetobacter baumannii isolates from invasive infections in 2009 in Poland. - Semantic Scholar  Molecular analysis of Acinetobacter baumannii isolates from invasive infections in 2009 in Poland. - Semantic Scholar
Acinetobacter-derived cephalosporinase [ADC]) (10) and a carbapenem-hydrolyzing class D -lactamase (CHDL; the OXA-51 type) (15 ... collected during a surveillance of invasive infections in Polish hospitals. These were all A. baumannii isolates from blood (n ... Acinetobacter baumannii is currently one of the key nosocomial pathogens causing severe infections; of special concern is its ... Molecular analysis of Acinetobacter baumannii isolates from invasive infections in 2009 in Poland.. *. Radosław Izdebski. , ...
more infohttps://www.semanticscholar.org/paper/Molecular-analysis-of-Acinetobacter-baumannii-isol-Izdebski-Fiett/42c9998a691870d50e2d03ff56629e3841a1a0df
Antibiograms of Multidrug-Resistant Clinical Acinetobacter baumannii: Promising Therapeutic Options for Treatment of Infection...  Antibiograms of Multidrug-Resistant Clinical Acinetobacter baumannii: Promising Therapeutic Options for Treatment of Infection...
Multidrug-resistant Acinetobacter baumannii infection has presented a global medical challenge. The antibiograms of paired ... Multidrug-resistant Acinetobacter baumannii infection has presented a global medical challenge. The antibiograms of paired ...
more infohttp://oxfordindex.oup.com/view/10.1086/520658
Infection by <i>Acinetobacter baumannii</i> and host immunity A novel bacterial transport mechanism Bacterial immunity taxi -...  Infection by <i>Acinetobacter baumannii</i> and host immunity A novel bacterial transport mechanism "Bacterial immunity taxi" -...
Hospital-acquired infections due to Acinetobacter baumannii have become problematic because of high rates of drug resistance. A ... Infection by Acinetobacter baumannii and host immunity A novel bacterial transport mechanism "Bacterial immunity taxi" ... Acinetobacter baumannii, neutrophil, neutrophil extracellular traps(NETs), Bacterial immunity taxi, sepsis. Received. January 5 ... Therefore, we must consider its interaction with host cells to understand diseases resulting from A. baumannii infection. ...
more infohttp://journal.chemotherapy.or.jp/detail_e.php?-DB=jsc&-recid=5282&-action=browse
Imipenem and Sulbactam in the Treatment of Imipenem-resistant Acinetobacter Baumannii Bacteremia - Full Text View -...  Imipenem and Sulbactam in the Treatment of Imipenem-resistant Acinetobacter Baumannii Bacteremia - Full Text View -...
Acinetobacter baumannii has been increasingly reported in the outbreak of nosocomial infections in the intensive care units, ... Infections caused by imipenem-resistant Acinetobacter baumannii are associated with high mortality and morbidity. The treatment ... Bacterial Infections. Sepsis. Infection. Systemic Inflammatory Response Syndrome. Inflammation. Pathologic Processes. Imipenem ... elder than 18 years old are included if they have bloodstream infections due to A. baumannii regardless of primary infection ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01374256
Welcome to CDC stacks | Multidrug-Resistant Acinetobacter baumannii Clone, France - 19025 | Emerging Infectious Diseases  Welcome to CDC stacks | Multidrug-Resistant Acinetobacter baumannii Clone, France - 19025 | Emerging Infectious Diseases
Acinetobacter Baumannii Acinetobacter Infections Algeria Anti-Bacterial Agents Antimicrobial Resistance Bacteria Beta- ... Extreme Drug Resistance in Acinetobacter baumannii Infections in Intensive Care Units, South Korea ... Cross Infection Egypt France Humans Letter Letters To The Editor Multidrug Resistance NDM-1 New Delhi Metallo-β-lactamase 1 ... A national alert was triggered in September 2003 when 4 hospitals reported clusters of A. baumannii infection with simila... ...
more infohttps://stacks.cdc.gov/view/cdc/19025
Renal and neurological side effects of colistin in critically ill patients | Annals of Intensive Care | Full Text  Renal and neurological side effects of colistin in critically ill patients | Annals of Intensive Care | Full Text
... for therapy of infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii in Siriraj Hospital ... Infection was cured in 79.1% of patients. Independent factors for a favorable infection outcome were antimicrobial regimens ... Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort study. Intensive Care Med ... Colistin and rifampicin in the treatment of multidrug-resistant Acinetobacter baumannii infections. J Antimicrob Chemother 2008 ...
more infohttps://annalsofintensivecare.springeropen.com/articles/10.1186/2110-5820-1-14
Nosocomial outbreaks caused by Acinetobacter baumannii and Pseudomonas aeruginosa: Results of a systematic review  Nosocomial outbreaks caused by Acinetobacter baumannii and Pseudomonas aeruginosa: Results of a systematic review
... researchers sought to determine risk factors for the occurrence and appropriate infection control measures. They observed that ... Acinetobacter outbreaks were mainly reported from intensive care units, after use of ... In view of the large outbreaks of infection by Acinetobacter baumannii and Pseudomonas aeruginosa, ... In view of the large outbreaks of infection by Acinetobacter baumannii and Pseudomonas aeruginosa, researchers sought to ...
more infohttp://www.hhmglobal.com/knowledge-bank/news/nosocomial-outbreaks-caused-by-acinetobacter-baumannii-and-pseudomonas-aeruginosa-results-of-a-systematic-review
Identification of clinical isolates of Acinetobacter baumannii from Iran and study of their heterogeneity  - Shahrekord...  Identification of clinical isolates of Acinetobacter baumannii from Iran and study of their heterogeneity - Shahrekord...
Background Acinetobacter baumannii has become one of the most serious causative agents of nosocomial infections due to its ... Identification of clinical isolates of Acinetobacter baumannii from Iran and study of their heterogeneity ... Identification of clinical isolates of Acinetobacter baumannii from Iran and study of their heterogeneity. Journal of the ...
more infohttp://eprints.skums.ac.ir/758/
Analyse der Interaktion von Acinetobacter baumannii mit humanen epithelialen Zellen  Analyse der Interaktion von Acinetobacter baumannii mit humanen epithelialen Zellen
Acinetobacter baumannii causes severe nosocomial infections such as pneumonia, meningitis and sepsis with high mortality rates ... Analyse der Interaktion von Acinetobacter baumannii mit humanen epithelialen Zellen. Download vts_6384_8594.pdf (1.556Mb) 152 ... The goal of this project was to analyse the interaction between clinical strains of Acinetobacter baumannii and human cells in ... A highly efficient Tn5 derivative was used for transposon mutagenesis of several species of Acinetobacter, as well as of ...
more infohttps://oparu.uni-ulm.de/xmlui/handle/123456789/1161
Acinetobacter baumannii bacteria, illustration - Stock Image F018/1264 - Science Photo Library  Acinetobacter baumannii bacteria, illustration - Stock Image F018/1264 - Science Photo Library
It causes various nosocomial infections, including, skin and wound infections, pneumonia, meningitis, septicaemia, urinary ... The illustration shows morphology of Acinetobacter such as short rods and sometimes long filamentous cells. - Stock Image F018/ ... tract infection and endocarditis. It is commonly found in soil, water, sewage, and normal skin and gastrointestinal tract flora ... Multi-drug resistant Acinetobacter baumannii bacteria inside biofilm, computer illustration. A. baumannii is a Gram-negative, ...
more infohttp://www.sciencephoto.com/media/843279/view
Iron and Acinetobacter baumannii Biofilm Formation | Università degli studi Roma Tre  Iron and Acinetobacter baumannii Biofilm Formation | Università degli studi Roma Tre
Acinetobacter baumannii is an emerging nosocomial pathogen, responsible for infection outbreaks worldwide. The pathogenicity of ... Acinetobacter baumannii is an emerging nosocomial pathogen, responsible for infection outbreaks worldwide. The pathogenicity of ...
more infohttps://iris.uniroma3.it/handle/11590/139925
Acinetobacter baumannii outer membrane protein A targets the n...  Acinetobacter baumannii outer membrane protein A targets the n...
Acinetobacter baumannii is an emerging opportunistic pathogen re ... Acinetobacter baumannii outer membrane protein A targets the ... Acinetobacter baumannii is an emerging opportunistic pathogen responsible for healthcare-associated infections. The outer ... Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity.. Authors * Choi, Chul Hee ...
more infohttps://www.mysciencework.com/publication/show/acinetobacter-baumannii-outer-membrane-protein-targets-nucleus-induces-cytotoxicity-308ed3c5
Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones. | Sigma...  Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones. | Sigma...
... baumannii infections. ... Acinetobacter baumannii has emerged as a pan-drug-resistant ... Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones.. [Danielle M ...
more infohttps://www.sigmaaldrich.com/catalog/papers/22853441
Multi-drug resistance profiles and the genetic features of Acinetobacter baumannii isolates from Bolivia  Multi-drug resistance profiles and the genetic features of Acinetobacter baumannii isolates from Bolivia
... topoisomerases are responsible for the multi-resistance of the bacteria and the subsequent difficulty in treating infections ... Multi-drug resistance profiles and the genetic features of Acinetobacter baumannii isolates from Bolivia. ... Introduction: Acinetobacter baumannii is opportunistic in debilitated hospitalised patients. Because information from some ...
more infohttps://addi.ehu.es/handle/10810/11335
Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. |...  Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. |...
Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. , ... Prevalence of infections/colonizations decreased, and no event occurred after 20th week. A colonized neonate developed CRAB ... Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. ... Between September and December 2011, eight neonates developed 10 CRAB infections (five blood, four respiratory and one eye). A ...
more infohttps://www.docphin.com/research/article-detail/13775114/PubMedID-24985124/Successful-management-of-an-outbreak-due-to-carbapenem-resistant-Acinetobacter-baumannii-in-a-neonatal-intensive-care-unit
Frequency of 16S rRNA Methylase and Aminoglycoside-Modifying Enzyme Genes among Clinical Isolates of Acinetobacter baumannii in...  Frequency of 16S rRNA Methylase and Aminoglycoside-Modifying Enzyme Genes among Clinical Isolates of Acinetobacter baumannii in...
The results showed that colistin was an effective antibiotic and could be used as a last-resort treatment of infections caused ... Multidrug-resistant Acinetobacter baumannii (MDR-AB) is an important nosocomial pathogen which is associated with significant ... The Acinetobacter isolate was specified as MDR if it was resistant to at least 3 classes of antibiotics (24). The rate of ... Multidrug-resistantAcinetobacter baumannii (MDR-AB) have recently emerged as a life-threatening pathogen which is responsible ...
more infohttp://ijp.iranpath.org/article_27989.html
Health News : Resistance protein in the superbug acinetobacter baumannii : 28 Nov 2013  Health News : Resistance protein in the superbug acinetobacter baumannii : 28 Nov 2013
The resistance protein has been called Acinetobacter Chlorhexidine Efflux, abbreviated to Ace. ... Scientists have recently identified a resistance protein that allows acinetobacter baumannii bacteria to survive chlorhexidine ... Such work is important in ensuring that we can continue to use successfully this antiseptic to reduce rates of infection in ... Resistance protein in the superbug acinetobacter baumannii. Click for more news from or about Leeds.. See also Books about ...
more infohttp://www.ivyroses.com/Health/superbug-acinetobacter-baumannii
  • Acinetobacter baumannii remains an important and difficult-to-treat pathogen whose resistance patterns result in significant challenges for the clinician. (oup.com)
  • These organisms were the most frequently recovered gram-negative isolate from war wounds and the second most frequent bacterium causing bloodstream infection in US Marines with extremity wounds during the Vietnam War ( 3 ). (cdc.gov)
  • In this assay, a naturally competent tryptophan auxotrophic mutant of Acinetobacter baylyi (BD4 trpE27) is transformed with the total DNA of a putative Acinetobacter isolate and the transformation mixture is plated on a brain heart infusion agar. (wikipedia.org)
  • Growth on the AMA indicates a positive transformation assay and confirms the isolate as a member of the genus Acinetobacter. (wikipedia.org)
  • Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. (medscape.com)
  • A premature baby died while four others were found sick at a New Jersey hospital because of a bacterial infection. (inquisitr.com)
  • According to reports, health officials are probing into bacterial infections in the neonatal intensive care unit of University Hospital in Newark following the death of the premature baby in late September. (inquisitr.com)
  • The infant contracted the bacterial infection but the exact cause of death is still under investigation due to compounding medical conditions. (inquisitr.com)
  • in December 2009 in a Swedish national who fell ill with an antibiotic-resistant bacterial infection that he acquired in India. (wikipedia.org)
  • Patients with Acinetobacter pneumonias occurring in the context of an outbreak in the intensive care unit (ICU) generally have a history of preceding contact with respiratory support monitors or equipment. (medscape.com)
  • In July 2010, a team in New Delhi reported a cluster of three cases of Acinetobacter baumannii bearing blaNDM-1 that were found in the intensive care unit of a hospital in Chennai, India, in April 2010. (wikipedia.org)
  • Despite the drug resistance that infecting organisms demonstrated in this series, a regimen of carefully selected extended antimicrobial-drug therapy appears effective for osteomyelitis caused by MDR Acinetobacter spp. (cdc.gov)
  • Such infections are challenging to treat because of extensive antimicrobial drug resistance. (cdc.gov)
  • So-called "superbugs" like MDR Acinetobacter undermine decades of advances made in medicine, surgery, and transplantation. (springer.com)
  • Wade said that acinetobacter is a hospital-acquired infection with no community transmission, which means that it does not pose risk of spreading in the Newark community. (inquisitr.com)