Acinetobacter Infections: Infections with bacteria of the genus ACINETOBACTER.Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.Acinetobacter baumannii: A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.Drug Resistance, Multiple, Bacterial: The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Acinetobacter calcoaceticus: A species of gram-negative, aerobic bacteria found in soil and water. Although considered to be normally nonpathogenic, this bacterium is a causative agent of nosocomial infections, particularly in debilitated individuals.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Cross Infection: Any infection which a patient contracts in a health-care institution.Carbapenems: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.Colistin: Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).beta-Lactamases: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.beta-Lactam Resistance: Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Tobacco Industry: The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.Cardiology: The study of the heart, its physiology, and its functions.Sleep Medicine Specialty: A medical specialty concerned with the diagnosis and treatment of SLEEP WAKE DISORDERS and their causes.Emergency Medicine: The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.Gastroenterology: A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Nephrology: A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.Neurology: A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.Urinary Tract Infections: Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.Disarticulation: Amputation or separation at a joint. (Dorland, 28th ed)OsteomyelitisIraqWar: Hostile conflict between organized groups of people.Thigh: The portion of the leg in humans and other animals found between the HIP and KNEE.Electrophoresis, Gel, Pulsed-Field: Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.Mice, Inbred ICRPeriodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)Periodontal Diseases: Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Dental Plaque: A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.Sri LankaMouth: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.Gingiva: Oral tissue surrounding and attached to TEETH.Biological Ontologies: Structured vocabularies describing concepts from the fields of biology and relationships between concepts.Madagascar: One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster's New Geographical Dictionary, 1988, p714)Hospitals, Military: Hospitals which provide care for the military personnel and usually for their dependents.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Medicine, Traditional: Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.Military Personnel: Persons including soldiers involved with the armed forces.AfghanistanHospitals, Packaged: Hospital equipment and supplies, packaged for long-term storage, sufficient to set up a general hospital in an emergency situation. They are also called Packaged Disaster Hospitals and formerly Civil Defense Emergency Hospitals.Haemophilus influenzae: A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.Gram-Negative Aerobic Bacteria: A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.Gentian Violet: A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.Phenazines
Acinetobacter bacteremia in Hong Kong: prospective study and review. (1/737)The epidemiological characteristics of 18 patients with acinetobacter bacteremia were analyzed. Patients (mean age, 55.5 years) developed bacteremia after an average of 14.1 days of hospitalization. Fifteen of 16 patients survived bacteremia caused by Acinetobacter baumannii. Cultures of blood from the remaining two patients yielded Acinetobacter lwoffii. Most patients (78%) resided in the general ward, while four patients (22%) were under intensive care. Genotyping by arbitrarily primed polymerase chain reaction analysis and the temporal sequence of isolation were more useful than phenotyping by antimicrobial susceptibility in the determination of the source of bacteremia, and the intravascular catheter was the leading infection source (39% of cases). The possibility of an association of glucose with the pathogenesis of acinetobacter infection was raised. (+info)
Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case-control study of adult burn patients. (2/737)Risk factors for Acinetobacter baumannii bloodstream infection (BSI) were studied in patients with severe thermal injury in a burn intensive care unit where A. baumannii was endemic. Of 367 patients hospitalized for severe thermal injury during the study period, 29 patients with nosocomial A. baumannii BSI were identified (attack rate, 7.9%). Cases were compared with 58 matched controls without A. baumannii BSI. The overall mortality rate was 31% among cases and 14% among controls; only two deaths (7%) were considered directly related to A. baumannii BSI. Molecular typing of A. baumannii blood isolates by means of randomly amplified polymorphic DNA analysis and pulsed-field gel electrophoresis revealed the presence of three different strain types. Multivariate analysis showed that female gender (P = .027), total body surface area burn of > 50% (P = .016), prior nosocomial colonization with A. baumannii at a distant site (P = .0002), and use of hydrotherapy (P = .037) were independently associated with the acquisition of A. baumannii BSI in burn patients. These data underscore the need for effective infection control measures for this emerging nosocomial problem. (+info)
Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii. (3/737)From March 1995 to March 1997, sulbactam was prospectively evaluated in patients with non-life-threatening multiresistant Acinetobacter baumannii infections. During this period, 47 patients were treated with sulbactam; of them, five were excluded because they had received < or =48 h of sulbactam therapy. A total of 42 patients, 27 males and 15 females with a mean age of 60+/-15 years, were finally evaluated. Infections were as follows: surgical wound, 19; tracheobronchitis, 12; urinary tract, 7; catheter-related bacteraemia, 2; and pneumonia, 2. Eighteen patients received intravenous sulbactam alone (1 g every 8 h) and 24 patients received intravenous sulbactam/ampicillin (1 g:2 g every 8 h) with no major adverse effects. Of the 42 patients, 39 improved or were cured and showed A. baumannii eradication and one patient had persistence of wound infection after 8 days of sulbactam/ampicillin requiring surgical debridement. Two patients died after 3 days of therapy (one of the deaths was attributable to A. baumannii infection). The in-vitro activity of the sulbactam/ampicillin combination was by virtue of the antimicrobial activity exhibited by sulbactam. Killing curves showed that sulbactam was bacteriostatic; no synergy was observed between ampicillin and sulbactam. Our results indicate that sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem. (+info)
Identification of Acinetobacter baumannii strains with monoclonal antibodies against the O antigens of their lipopolysaccharides. (4/737)Despite the emergence of Acinetobacter baumannii strains as nosocomial pathogens, simple methods for their phenotypic identification are still unavailable. Murine monoclonal antibodies specific for the O-polysaccharide moiety of the lipopolysaccharide (LPS) of two A. baumannii strains were obtained after immunization with heat-killed bacteria. The monoclonal antibodies were characterized by enzyme immunoassay and by Western and dot blot analyses and were investigated for their potential use for the identification of A. baumannii strains. The antibodies reacted with 46 of the 80 A. baumannii clinical isolates that were investigated, and reactivity was observed with 11 of 14 strains which were isolated during outbreaks in different northwestern European cities; no reactivity was observed with Acinetobacter strains of other genomic species, including the closely related genomic species 1 (Acinetobacter calcoaceticus), 3, and 13 sensu Tjernberg and Ursing, or with other gram-negative bacterial strains. The results show that O-antigen-specific monoclonal antibodies such as the ones described are convenient reagents which can be used to identify Acinetobacter strains in clinical and research laboratories. (+info)
Some immunological properties of lipopolysaccharide from Acinetobacter baumannii. (5/737)Acinetobacter baumannii, mainly biotype 9, is an important nosocomial opportunist pathogen in Chile and other countries. The biological basis of its virulence and prevalence is still unknown. As lipopolysaccharide (LPS) is often associated with virulence, some biological properties of purified LPS from seven nosocomial isolates, comprising four isolates of A. baumannii biotype 9, two isolates of biotype 8 and one isolate of biotype 1, were investigated. LPS was extracted and purified from each isolate by the hot phenol-water method, and its ability to elicit a mitogenic response and to induce the synthesis of a tumour necrosis factor (TNF-alpha) in mouse spleen cells was determined. Activity was evaluated in vivo by determining the splenic index in comparison with LPS from Salmonella Typhimurium. All seven LPS samples were mitogenic on the basis of cellular proliferation experiments and six induced synthesis of TNF-alpha. Similar results were obtained in in-vivo experiments in which LPS induced spleen cell growth, as shown by determination of the splenic index. These results suggest that the LPS of A. baumannii might contribute to the pathogenic properties of this species. (+info)
Use of a murine O-antigen-specific monoclonal antibody to identify Acinetobacter strains of unnamed genomic species 13 Sensu Tjernberg and Ursing. (6/737)A monoclonal antibody against the O-antigenic polysaccharide chain of the lipopolysaccharide (LPS) of Acinetobacter strains belonging to the unnamed genomic species 13 Sensu Tjernberg and Ursing (13TU) was obtained after immunization of BALB/c mice with heat-killed bacteria and was characterized by enzyme immunoassay and Western blot analysis, by use of LPS and proteinase K-treated bacterial lysates, analyses in which the antibody was shown to be highly specific for the homologous antigen. In addition, when tested in dot and Western blots, reactivity was observed with 9 of 18 Acinetobacter strains of genomic species 13TU which had been isolated in Germany and Denmark; no reactivity was observed with strains of other genomic species, including the closely related genomic groups 1 (A. calcoaceticus), 2 (A. baumannii), and 3 (unnamed), or with other gram-negative bacteria. The antibody described here represents a convenient reagent for the simple, economical, and accurate differentiation of clinical isolates of genomic species 13TU from other Acinetobacter strains. Although the antibody does not identify all isolates of this genomic group, it is evident that it will be a useful reagent in the development of a serotyping scheme for clinical laboratories. (+info)
Genotypic and phenotypic similarity of multiresistant Acinetobacter baumannii isolates in the Czech Republic. (7/737)The diversity of 103 clinical isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex obtained between 1991 and 1997 from 17 Czech hospitals was studied by ribotyping, biotyping, plasmid profiling and antibiotic susceptibility testing. According to the EcoRI ribotypes, all but one of these isolates were identified to the DNA group level: 77 isolates were allocated to DNA group 2 (A. baumannii), 14 to DNA group 3, 10 to DNA group 13 sensu Tjernberg and Ursing and one to DNA group 1 (A. calcoaceticus). In total, 50 different EcoRI ribotypes and 10 biotypes were observed. Plasmids were found in 92% of the isolates and a high variability in plasmid profiles was found in isolates of the same DNA group. The combination of typing profiles allowed two predominant groups (termed A and B) to be distinguished among the A. baumannii isolates (37 and eight isolates, respectively) that shared a specific ribotype and were highly similar in other properties. These two groups comprised both sporadic and outbreak isolates and were found in most localities. Group A and B isolates were markedly more resistant to antibiotics than most of the remaining isolates, thus representing 85% of all multiresistant isolates. The features of groups A and B corresponded to those of two epidemic clones identified recently among hospital strains in north-western Europe. (+info)
In vivo efficacies of combinations of beta-lactams, beta-lactamase inhibitors, and rifampin against Acinetobacter baumannii in a mouse pneumonia model. (8/737)The effects of various regimens containing combinations of beta-lactams, beta-lactam inhibitor(s), and rifampin were assessed in a recently described mouse model of Acinetobacter baumannii pneumonia (M. L. Joly-Guillou, M. Wolff, J. J. Pocidalo, F. Walker, and C. Carbon, Antimicrob. Agents Chemother. 41:345-351, 1997). Two aspects of the therapeutic response were studied: the kinetics of the bactericidal effect (treatment was initiated 3 h after intratracheal inoculation, and bacterial counts were determined over a 24-h period) and survival (treatment was initiated 8 h after inoculation, and the cumulative mortality rate was assessed on day 5). Two clinical strains were used: a cephalosporinase-producing strain (SAN-94040) and a multiresistant strain (RCH-69). For SAN-94040 and RCH-69, MICs and MBCs (milligrams per liter) were as follows: ticarcillin, 32, 64, 256, and >256, respectively; ticarcillin-clavulanate, 32, 64, and 512, and >512, respectively; imipenem, 0.5, 0.5, 8, and 32, respectively; sulbactam, 0.5, 0.5, 8, and 8, respectively; and rifampin, 8, 8, 4, and 4, respectively. Against SAN-94040, four regimens, i.e., imipenem, sulbactam, imipenem-rifampin, and ticarcillin-clavulanate (at a 25/1 ratio)-sulbactam produced a true bactericidal effect (>/=3-log10 reduction of CFU/g of lung). The best survival rate (i.e., 93%) was obtained with the combination of ticarcillin-clavulanate-sulbactam, and regimens containing rifampin provided a survival rate of >/=65%. Against RCH-69, only regimens containing rifampin and the combination of imipenem-sulbactam had a true bactericidal effect. The best survival rates (>/=80%) were obtained with regimens containing rifampin and sulbactam. These results suggest that nonclassical combinations of beta-lactams, beta-lactamase inhibitors, and rifampin should be considered for the treatment of nosocomial pneumonia due to A. baumannii. (+info)
Acinetobacter Infections - Pipeline Review, H1 2017 Summary Latest Pharmaceutical and Healthcare disease pipeline guide Acinetobacter Infections - Pipeline
Bacterial infections due to Acinetobacter species are typically encountered in health care settings and can be particularly difficult to treat due to the propensity of the organism to incorporate multiple antibiotic resistance mechanisms. Hospital outbreaks of multidrug-resistant Acinetobacter infections have been reported. A wide range of infections are possible with this organism, including bloodstream infections, pneumonia (occasionally even community-acquired pneumonia), urinary tract infections, and wound infections (wound infection in soldiers after traumatic injury have been reported ...
Infection with antibiotic-resistant Acinetobacter spp. is an increasing problem in critical care environments worldwide. Acinetobacter spp. are known to produce an insulin-cleaving protease. We hypothesized that infection with Acinetobacter spp. was associated with the acquisition of glucose intolerance in burn patients. Data were collected prospectively on all 473 patients admitted to the Burns Centre between January 2002 and March 2003. A total of 3.4% of patients acquired glucose intolerance during admission. Patients with Acinetobacter spp. infection were 9.8 times more likely to develop glucose intolerance than those without the infection (P | .0001). The association persisted after controlling for TBSA (P | .001). In patients with deep Acinetobacter spp. infection, 47% had glucose intolerance, compared with 12% in those with infection of the burn only (P = .03). In patients with pre-existing diabetes mellitus, 27% developed Acinetobacter spp. infection compared with only 8.5% of patients without
Clinical features and outcomes of Acinetobacter species and Pseudomonas aeruginosa. Presented at the 46th Interscience infections due buy Xanax tablets online UK multidrug resistant baumannii Ab bloodstream infections BSI. Antimicrob Agents Chemother 200751376 378 391 Fournier PE. Clin Infect Dis 1996221026 1032 Carey RB, Banerjee SN. baumannii correlated with an increased 1999 Marmara earthquake. Surveillance cultures and duration of carriage of multidrug resistant Acinetobacter. Seasonal variation of Acinetobacter infections Clin Microbiol Rev 200619257. J Clin Microbiol 2006443623 3627 of resistance to tigecycline has. Crit Care Med 2005331136 1140 of broad spectrum antibiotics. References Schreckenberger PC, Daneshvar with multidrug resistant Pseudomonas aeruginosa. Presented at the 46th Interscience outbreaks of acinetobacter infections, most even more limited. PLoS Genet 20062e7 e7 of Acinetobacter spp. Source Information From Medical for nonsusceptibility in Acinetobacter baumannii. 79 An ...
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outbreaks of carbapenem-resistant A. baumannii infection occurred in a hospital in New York City. Subsequently, numerous other hospitals in the United States and South America have had outbreaks of carbapenem-resistant A. baumannii. The incidence of infections with A. baumannii among military personnel from the United States and Canada has increased since 2002; 102 patients had bloodstream infections at facilities treating U.S. military personnel injured in Iraq or Afghanistan from January 1, 2002, through August 31, 2004. An epidemiologic investigation revealed that A. baumannii could be grown from environmental sites in field hospitals and that the environmental strains were closely related genotypically to clinical isolates. A. baumannii strains from injured military personnel from the United States and the United Kingdom were also genotypically related; this finding provided further evidence that A. baumannii was being acquired in field hospitals.. ...
Acinetobacter spp. are a diverse group of Gram-negative bacteria frequently implicated in nosocomial infections. Genotypic methods have been instrumental in studying Acinetobacter, but few offer high resolution, rapid turnaround time, technical ease and high inter-laboratory reproducibility, which has hampered understanding of disease incidence, transmission patterns and diversity within this genus. Here, we further evaluated multilocus PCR electrospray ionization/ mass spectrometry (PCR/ESI-MS), a method that is simple and robust, and provides both species characterization and strain-level resolution of Acinetobacter spp. on a single platform. We examined 125 Acinetobacter isolates from 21 hospitals, laboratories and medical centres spanning four counties in Arizona, USA, using PCR/ESI-MS. We compared PCR/ESI-MS with an in-house amplified fragment length polymorphism (AFLP) genotyping scheme. PCR/ESI-MS demonstrated that Acinetobacter spp. from Arizonan hospitals had similar species and strain
Prompt detection of metallo-beta-lactamase (MBL) producing isolates is necessary to prevent their dissemination. Frequency of MBLs producing strains among multidrug resistant (MDR) Acinetobacter species and Pseudomonas aeruginosa was evaluated in critical care Patients using imipenem-EDTA disk method. One hundred MDR Acinetobacter spp. and 42 Pseudomonas aeruginosa were checked for MBL production, from January to June 2001. MBL was produced by 96.6 % of imipenem-resistant Acinetobacter isolates, whereas 100% imipenem-resistant Pseudomonas aeroginosa isolates were MBL producers. Carbapenem resistance in MDR Acinetobacter spp. and Pseudomonas aeruginosa isolates in this study was due to MBLs. This calls for strict infection control measures to prevent further dissemination.
War wound infection and osteomyelitis caused by multidrug-resistant (MDR) Acinetobacter species have been prevalent during the 2003-2005 military operations in Iraq. Twenty-three soldiers wounded in Iraq and subsequently admitted to our facility from March 2003 to May 2004 had wound cultures positive for Acinetobacter calcoaceticus-baumannii complex. Eighteen had osteomyelitis, 2 burn infection, and 3 deep wound infection. Primary therapy for these infections was directed antimicrobial agents for an average of 6 weeks. All soldiers initially improved, regardless of the specific type of therapy. Patients were followed up to 23 months after completing therapy, and none had recurrent infection with Acinetobacter species. Despite the drug resistance that infecting organisms demonstrated in this series, a regimen of carefully selected extended antimicrobial-drug therapy appears effective for osteomyelitis caused by MDR Acinetobacter spp.
Teck Wee Boo, Molecular characterisation of carbapenem resistance of Acinetobacter species in an Irish tertiary care hospital, [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2010, pp 377 ...
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... As definições de siglas Acinetobacter. As definições de acrónimo Acinetobacter. Sigla Acinetobacter significa para. Além de encontrar siglas. Encontre o que significam as siglas!
海词词典，最权威的学习词典，专业出版acinetobacter winogradskyii是什么意思，acinetobacter winogradskyii的用法，acinetobacter winogradskyii翻译和读音等详细讲解。海词词典：学习变容易，记忆很深刻。
海词词典，最权威的学习词典，专业出版acinetobacter baummanii是什么意思，acinetobacter baummanii的用法，acinetobacter baummanii翻译和读音等详细讲解。海词词典：学习变容易，记忆很深刻。
Qpex Biopharma to Provide First Public Presentations of Preclinical Data on the Novel Ultra-Broad-Spectrum Beta-lactamase Inhibitor QPX7728 for IV and Oral Products at 2019 ASM Microbe Meeting. . SAN DIEGO, June 13, 2019 - Qpex Biopharma today announced that preclinical data on its investigational beta-lactamase inhibitor QPX7728 will be featured in several presentations at the 2019 ASM Microbe Meeting to be held June 20-24 in San Francisco, CA.. . "We are pleased to be making the first public presentations on our next generation beta- lactamase inhibitor QPX7728 that exceeds the profile of other agents recently approved or in clinical development." said Michael Dudley, PharmD, President and CEO of Qpex Biopharma. "QPX7728s potent inhibition of major beta-lactamases, including metallo enzymes, and activity in multi-drug resistant Acinetobacter as well as Enterobacteriaceae and Pseudomonas aeruginosa represents a major advance in the field. QPX7728 has the potential for use in combination ...
ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.. About ASM , Contact Us , Press Room. ASM is a member of. ...
Resistência aos antibióticos β-lactâmicos em isolados clínicos de Acinetobacter spp : caracterização molecular de novas carbapenemases, IMP-5 e OXA-33, e estudo da relação clonal entre os isolados resistentes ao ...
Bacterial infection is a major cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Streptococcus pneumoniae (SP) and Haemophilus influenza (HI) are the most frequently encountered.. Objectives: Studying the relation between the bacteriologic etiology of AECOPD and severity of the disease.. Methods: This is a retrospective study of patients with COPD hospitalised for AECOPD and whose bacteriological sputum was used to isolate the causative agent. In this study, we correlated the parameters of severity of the disease with isolated bacteria.. Results: 225 germs were isolated from 180 patients. The infection was polymicrobial in 19 patients. The bacteria isolated were: SP:18 cases, HI:42 cases, Pseudomonas:37 cases and Acinetobacter:14 cases. Patients that experienced pyocyanic and/or Acinetobacter infections are more symptomatic than COPD patients with past history of exacerbations due to HI and/or SP (mMRC=2-4: 86% vs 71%, p=0,049), most often GOLD 3 and 4 (89% vs ...
Biohazard level, growth media and temperature, gram stain, industrial applications and more information for Acinetobacter bouvetii.
Las especies de Acinetobacter son, relativamente, microorganismos inofensivos con una gran capacidad de persistir en los ambientes hospitalarios por periodos prolongados como colonizantes y pudiendo ser una causa importante ...
Members of the genus Acinetobactercan frequently be isolated from healthy people and are also commonly present in soil and water as free-living saprophytes. In spite of an increasing number of...
Objectives. Multidrug-resistant Acinetobacter strain HK302 was isolated from an outbreak of nosocomial infections in Switzerland in 1977. The aim of the present study was to assess whether this archive strain belongs to one of the known international clonal lineages of Acinetobacter baumannii and whether it harbours a genomic structure related to the AbaR1-like resistance islands.. Methods. Multilocus sequence typing (MLST) and HindIII ribotyping were used to determine the taxonomic position of HK302 at the species and subspecies (clonal) levels. The position and structure of the putative resistance island were investigated by AbaR1-based PCR mapping followed by restriction analysis and partial sequencing of amplicons. A. baumannii AYE harbouring AbaR1 was used as a positive control for PCR mapping.. Results. The MLST allelic profile (1-1-1-1-5-1-1) and HindIII ribotype of HK302 were typical of A. baumannii European (EU) clone I. In addition, an AbaR1-related region inserted into the ATPase gene ...
Nosocomial pathogens can be associated with a variety of infections, particularly in intensive care units (ICUs) and in immunocompromised patients. Usually these pathogens are resistant to multiple drugs and pose therapeutic challenges. Among these organisms, Acinetobacter baumannii is one of the most frequent being encountered in the clinical setting. Carbapenems are very useful to treat infections caused by these drug-resistant Gram-negative bacilli, but carbapenem resistance is increasing globally. Combination therapy is frequently given empirically for hospital-acquired infections in critically ill patients and is usually composed of an adequate beta-lactam and an aminoglycoside. The purpose of this study was to evaluate the in vitro activity of plazomicin against carbapenem-resistant Acinetobacter baumannii. Amikacin was used as a comparator. The activity of plazomicin in combination with several different antibiotics was tested by disk diffusion, the checkerboard method, and time-kill ...
Acinetobacter baumannii has been increasingly reported in the outbreak of nosocomial infections in the intensive care units, which not only prolong the length of hospital stay but result in high attributable mortality. With its intrinsic resistance to many antimicrobial agents and rapid acquirement of resistance mechanism, resistance to carbapenems, which is often accompanied with resistance to multiple drugs, has emerged worldwide. The limited treatment choice included tigecycline, colistin, and sulbactam. However, the low serum level and bacteriostatic nature of tigecycline hamper its application in blood stream infection, one of the most common presentations of A. baumannii infections. The nephrotoxicity and neurotoxicity of intravenous colistin have caused great concerns in critically ill patients whereas immediate bronchospasm after inhalation and significant clinical consequences have been reported. Sulbactam has been used for decades in combination of ampicillin and well tolerated. ...
Objective To investigate the in vitro and in vivo antibacterial activities of tigecycline and other 13 common antimicrobial agents, alone or in combination, against multi-drug resistant Acinetobacter baumannii.MethodsAn in vitro susceptibility test of 101 Acinetobacter baumannii was used to detect minimal inhibitory concentrations (MICs). A mouse lung infection model of multi-drug resistant Acinetobacter baumannii,established by the ultrasonic atomization method, was used to define in vivo antimicrobial activities.Results Multi-drug resistant Acinetobacter baumannii showed high sensitivity to tigecycline (98% inhibition), polymyxin B (78.2% inhibition), and minocycline (74.2% inhibition). However, the use of these antimicrobial agents in combination with other antimicrobial agents produced synergistic or additive effects. In vivo data showed that white blood cell (WBC) counts in drug combination groups C (minocycline + amikacin) and D (minocycline + rifampicin) were significantly higher than in groups A
PubMedID: 24985124 | Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. | European journal of pediatrics | 7/2/2014
Carbapenem resistance in A. baumannii is most often associated with class D β-lactamases (OXA-23-like, OXA-40-like and OXA-58-like) and MBLs. OXA-type carbapenemases are predominant in A. baumannii, particularly in worldwide outbreaks of OXA-23 . The molecular analysis of the isolates tested in this study revealed that 14 strains (51.8 %) carried the blaOXA-23-like gene and that two strains carried a blaOXA-24-like gene. All of the strains had a blaOXA-51-like gene, and four strains had a blaOXA-58 gene. In this study, the OXA-58 isolates presented lower MIC values for meropenem than OXA-23-like-positive isolates, which systematically exhibited higher MIC values (Table 1). The isolates with non-acquired OXA genes displayed a marked variation and included some carbapenem-resistant genes. Naturally occurring OXA carbapenemases, such as OXA-51-like enzymes (e.g., OXA 64-66, OXA 68-71, OXA 78-80, OXA-82, OXA-86, OXA-92 and OXA104-112), have been identified in A. baumannii isolates worldwide. In ...
Identifying Risk Factors for Healthcare-Associated Infections Caused by Carbapenem-Resistant Acinetobacter baumannii in a Neonatal Intensive Care Unit
In February 2006, a patient colonized with a multidrug-resistant sequence type 56 Acinetobacter baumannii strain was admitted to a hospital in Madrid, Spain. This strain spread rapidly and caused a large outbreak in the hospital. Clinicians should be ...
TY - JOUR. T1 - Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan. AU - Liu, S. Y.. AU - Lin, J. Y.. AU - Chu, C.. AU - Su, L. H.. AU - Lin, T. Y.. AU - Chiu, C. H.. PY - 2006/1. Y1 - 2006/1. N2 - We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the blaIMP-1 gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no blaIMP, blaVIM or bla CFI genes, indicating that other uncharacterised metallo-β- lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of ...
Acinetobacter junii is a species of bacteria. Its type strain is ATCC 17908. It can be pathogenic. This bacterium has been linked to nosocomial infections including catheter-related blood stream infections and cellulitis. Vaneechoutte, M.; De Baere, T.; Nemec, A.; Musilek, M.; Van Der Reijden, T. J. K.; Dijkshoorn, L. (2008). "Reclassification of Acinetobacter grimontii Carr et al. 2003 as a later synonym of Acinetobacter junii Bouvet and Grimont 1986". International Journal of Systematic and Evolutionary Microbiology. 58 (4): 937-940. doi:10.1099/ijs.0.65129-0. PMID 18398198. Bouvet, P. J. M.; Grimont, P. A. D. (1986). "Taxonomy of the Genus Acinetobacter with the Recognition of Acinetobacter baumannii sp. nov., Acinetobacter haemolyticus sp. nov., Acinetobacter johnsonii sp. nov., and Acinetobacter junii sp. nov. and Emended Descriptions of Acinetobacter calcoaceticus and Acinetobacter lwoffii". International Journal of Systematic Bacteriology. 36 (2): 228-240. doi:10.1099/00207713-36-2-228. ...
Patients with AB bacteremia receiving antimicrobial therapy are eligible for this multicenter study. Antimicrobial agents are decided at the discretion of the attending clinical team. Clinical data to be collected include patient demographics (age, gender, underlying diseases, Pitt Bacteremia Score , duration of ICU stay and hospitalization before the day of first positive blood culture, central venous catheterization), antimicrobial agents on the day of bacteremia, regimens and durations of combination therapy after enrollment, and outcomes (sequential quantification change of blood A. baumannii polymerase chain reaction [PCR], survival at day 30 after enrollment, and adverse drug reactions of antimicrobial agents). Blood sample will be collected on the day of enrollment (Day 0), Day 1, 2, 3 and 7 for PCR quantification of A. baumannii and for genospecies identification. Primary end points are the interval from study enrollment to negative blood A. baumannii PCR and blood sterilization. ...
Bacteria of the genus Acinetobacter are ubiquitous in nature. These organisms were invariably susceptible to many antibiotics in the 1970s. Since that time, acinetobacters; have emerged as multiresistant opportunistic nosocomial pathogens. The taxonomy of the genus Acinetobacter underwent extensive revision in the mid-1980s, and at least 32 named and unnamed species have now been described. Of these, Acinetobacter baumannii and the closely related unnamed genomic species 3 and 13 sensu Tjernberg and Ursing (13TU) are the most relevant clinically. Multiresistant strains of these species causing bacteraemia, pneumonia, meningitis, urinary tract infections and surgical wound infections have been isolated from hospitalised patients worldwide. This review provides an overview of the antimicrobial susceptibilities of Acinetobacter spp. in Europe, as well as the main mechanisms of antimicrobial resistance, and summarises the remaining treatment options for multiresistant Acinetobacter infections. © ...
Rates of A. baumannii bacteraemia significantly increased between 2005 and 2009, from 0.1 to 3.2 cases/100,000 inhabitants per year. The observed increase was due to carbapenem-resistant isolates, while the number of carbapenem-susceptible isolates remained substantially stable over the study period. Importantly, the occurrence of carbapenem-resistant isolates showed a steep five-fold increase between 2008 and 2009. These isolates belonged to an epidemic strain detected in several departments of 4 hospital trusts in the Region. Similar trends were observed for urine and respiratory isolates. The total number of isolates in blood, urine and respiratory specimens, including both colonizing and infecting strains, increased from 51 in 2005 to 826 in 2009, with rates rising from 1.5 to 19.0 isolates/100,000 inhabitants per year. ...
As part of the SENTRY Antimicrobial Surveillance Program, a total of 1078 Acinetobacter species and 842 Stenotrophomonas maltophilia isolates were collected between January 1997 and December 1999 from 5 geographic regions (Canada, the United States, Latin America, Europe, and the Asia-Pacific). The frequency of infections (by geographic region and body site), including those due to imipenem-resistant Acinetobacter species and trimethoprim-sulfamethoxazole (TMP-SMZ)-resistant S. maltophilia, was evaluated. The possibility of seasonal variations in bloodstream infections caused by Acinetobacter species was studied, as was the activity of several therapeutic antimicrobials against all strains. Acinetobacter species and S. maltophilia were most frequently associated with pulmonary infections, independent of the region evaluated. In contrast, patterns of antimicrobial resistance markedly varied among distinct geographic regions, especially for nosocomial isolates. Although the carbapenems were the ...
This unit describes basic protocols for infecting mice through intranasal and intraperitoneal routes with Acinetobacter baumannii to induce associated pneumonia and sepsis, the two most common manifestations of clinical infections with this pathogen
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To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for MDR, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigated 118 patients, on 27 wards, in whom MDR A. baumannii was isolated from clinical cultures. Each case-patient had a control without MDR A. baumannii and was matched for hospital length of stay, ward, and calendar time. The epidemiologic investigation found small clusters of up to 6 patients each with no common identified source. Ten different PFGE clones were found, of which 2 dominated. The PFGE pattern differed within temporospatial clusters, and antimicrobial drug susceptibility patterns varied within and between clones. Multivariate analysis identified the following significant risk factors: male sex, cardiovascular disease, having undergone mechanical ventilation, and having been treated with
In recent years, the number of nosocomial infections caused byAcinetobacter baumannii has increased significantly (4). Many outbreaks have been reported, especially among patients confined to hospital intensive care units, where the widespread use of antibiotics may select multidrug-resistant strains. The difficulty of treating A. baumannii nosocomial infection is associated with the high resistance to a wide range of antimicrobial agents frequently observed in this species (8). Often, imipenem remains one of the few therapeutic alternatives. Fortunately, imipenem resistance is relatively rare among Acinetobacter clinical isolates. Carbapenem resistance can arise by a decrease in expression of an outer membrane protein (3) or by alteration in penicillin-binding proteins (5). In general, the emergence of carbapenem-hydrolyzing enzymes has been limited compared to the prevalence of other β-lactamases (1). However, in 1985 in Scotland, anA. baumannii strain that produced a plasmid-mediated ...
Multi-drug resistant Acinetobacter baumannii bacteria inside biofilm, computer illustration. A. baumannii is a Gram-negative, oxidase negative, aerobic, coccobacillus. It has always been naturally resistant to multiple antibiotics. It can be especially resistant to penicillin and chloramphenicol. It causes various nosocomial infections, including, skin and wound infections, pneumonia, meningitis, septicaemia, urinary tract infection and endocarditis. It is commonly found in soil, water, sewage, and normal skin and gastrointestinal tract flora. It is the most frequently encountered species in the clinical laboratory. Species found in soil can colonize root nodule systems and oxidize the hydrogen produced by nitrogen fixing bacteria. The illustration shows morphology of Acinetobacter such as short rods and sometimes long filamentous cells. - Stock Image F018/1264
Molecular characterization and antimicrobial susceptibility of Acinetobacter baumannii isolates obtained from two hospital outbreaks in Los Angeles County, California, USA
Acinetobacter baumannii is currently one of the key nosocomial pathogens causing severe infections; of special concern is its resistance to expanded-spectrum cephalosporins (ESCs) and carbapenems, often associated with the few so-called European clones (6, 7, 19). It has two natural -lactamases, an AmpC-like enzyme (Acinetobacter-derived cephalosporinase [ADC]) (10) and a carbapenem-hydrolyzing class D -lactamase (CHDL; the OXA-51 type) (15), which affect susceptibility upon increased expression due to ISAba1 insertion upstream of their genes (9, 18). Moreover, acquired -lactamases, including metallo-lactamases (MBLs) and four CHDL types, the OXA-23, OXA-24/40, OXA-58, and OXA-143 types, are observed (15). Knowledge of A. baumannii in Poland has been limited to single isolates (9, 14, 21); our aim was to analyze a bigger group of A. baumannii strains. (Part of this work was presented at the 22nd European Congress of Clinical Microbiology and Infectious Diseases, London, United Kingdom, 31 March to 3
Acinetobacter (/ˌæsɪˈniːtoʊbæktər/) is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria. Acinetobacter species are oxidase-negative, exhibit twitching motility, and occur in pairs under magnification. They are important soil organisms, where they contribute to the mineralization of, for example, aromatic compounds. Acinetobacter species are a key source of infection in debilitated patients in the hospital, in particular the species Acinetobacter baumannii. Species of the genus Acinetobacter are strictly aerobic, nonfermentative, Gram-negative bacilli. They show mostly a coccobacillary morphology on nonselective agar. Rods predominate in fluid media, especially during early growth. The morphology of Acinetobacter species can be quite variable in Gram-stained human clinical specimens, and cannot be used to differentiate Acinetobacter from other common causes of infection. Most strains of Acinetobacter, except some of the A. lwoffii strain, grow well on ...
Acinetobacter baumannii causes severe nosocomial infections such as pneumonia, meningitis and sepsis with high mortality rates. This organism represents an increasing danger for immunocompromised adults, especially since there are an increasing number of resistances against antibiotics. Until now, scientific investigation was mainly focused on taxonomy and antibiotic resistance mechanisms. The goal of this project was to analyse the interaction between clinical strains of Acinetobacter baumannii and human cells in order to address the molecular mechanisms causing pathogenicity. Adherence is the first step in colonization of human tissue, and therefore a key event in pathogenesis. To demonstrate the adhesion of bacteria to human cells, a colony counting assay has been established. These experiments used the the type strain of A. baumannii ATCC 19606, as well as clinical isolates. All A. baumannii strains investigated showed adhesion to the lung epithelial cells A549, but the adhesion capacity was ...
Acinetobacter baumannii ATCC ® 19606D-5™ Designation: Genomic DNA from Acinetobacter baumannii strain 2208 TypeStrain=True Application: Food testing
Acinetobacter baumannii ATCC ® 19606D-5™ Designation: Genomic DNA from Acinetobacter baumannii strain 2208 TypeStrain=True Application: Food testing
A. baumannii is commonly involved in nosocomial infections, but few therapeutic options are available. Find out what there is to know.
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TY - JOUR. T1 - Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections. AU - Ostorhazi, Eszter. AU - Rozgonyi, Ferenc. AU - Sztodola, Andras. AU - Harmos, Ferenc. AU - Kovalszky, Ilona. AU - Szabo, Dora. AU - Knappe, Daniel. AU - Hoffmann, Ralf. AU - Cassone, Marco. AU - Wade, John D.. AU - Bonomo, Robert A.. AU - Otvos, Laszlo. PY - 2010/9/1. Y1 - 2010/9/1. N2 - Objectives: The designer antibacterial peptide A3-APO is efficacious in mouse models of Escherichia coli and Acinetobacter baumannii systemic infections. Here we compare the efficacy of the peptide with that of imipenem and colistin in A. baumannii wound infections after burn injury. Methods: CD-1 mice were inflicted with burn wounds and different inocula of A. baumannii, isolated from an injured soldier, were placed into the wound sites. The antibiotics were given intramuscularly (im) one to five times. Available free peptide in the blood and the ...
INTRODUCTION: The incidence of multidrug resistant microorganisms worldwide is increasing. The aim of the study was to present institutional experience with the multidrug resistant microorganism colonization patterns observed in children with congenital heart diseases hospitalized in a hybrid pediatric cardiac surgery center. MATERIAL AND METHODS: Microbiological samples were routinely collected in all children admitted to our department. All microbiological samples were analyzed with regard to multidrug resistant microorganisms: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Gram-negative rods producing extended-spectrum beta-lactamases (ESBL), multidrug resistant Gram-negative rods (MDR-GNRs), carbapenemase-producing Klebsiella pneumoniae (KPC), carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA ...
Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ... Human papillomavirus (HPV) infection One of the Human papillomaviruses Human parainfluenza virus infection Human parainfluenza ... Infections associated with diseases. References. *^ Walsh TJ, Dixon DM (1996). Baron S, et al., eds. Spectrum of Mycoses ... Haemophilus influenzae infection Haemophilus influenzae Hand, foot and mouth disease (HFMD) Enteroviruses, mainly Coxsackie A ...
Used to treat XDR Acinetobacter baumannii infections. Tolcapone - used in patients with Parkinson's disease who are not ... used as drug of last resort for a variety of different bacterial infections. Clomethiazole - a sedative/hypnotic agent used in ... its usefulness only as an injectable and potency in treatment of infection with multiple drug-resistant organisms has caused a ...
Use of colistin to treat Acinetobacter baumannii infections has led to the development of resistant bacterial strains. which ... Towner K J (2008). "Molecular Basis of Antibiotic Resistance in Acinetobacter spp.". Acinetobacter Molecular Biology. www. ... and it has come into recent use for treating multidrug-resistant Acinetobacter infection, although resistant forms have been ... "Colistin and rifampicin in the treatment of nosocomial infections from multiresistant Acinetobacter baumannii". Journal of ...
Infections caused by the non-fermenting gram-negative bacteria Pseudomonas aeruginosa and Acinetobacter baumanni are most ... Rice LB (2006). "Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter ... and meropenem are recommended for high-risk community-acquired abdominal infections and for abdominal infections that are ... "Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection ...
Almost half of hospital patients who get bloodstream CRE infections die from the infection. Acinetobacter is a gram-negative ... Infections are most frequent in people who have had recent medical and/or antibiotic treatment. C. difficile infections ... Associated with these infections were an estimated 15,000 deaths. The CDC estimates that C. difficile infection costs could ... Centers for Disease Control Prevention (CDC). (2004). "Acinetobacter baumannii infections among patients at military medical ...
Risk factors for infection with an MDR strain include ventilation for more than five days, recent hospitalization (last 90 days ... It is often resistant to a wide array of antibiotics but is usually sensitive to co-trimoxazole Acinetobacter are becoming more ... Even in cases with positive blood cultures, the bacteremia may be from a source other than the lung infection. Prevention of ... Ventilator-associated pneumonia is a type of lung infection that occurs in people who are on mechanical ventilation breathing ...
... associated with hospital-acquired infections include Acinetobacter baumannii, which cause bacteremia, ... It has also been studied in gram-negative species found in soil such as Pseudomonas stutzeri, Acinetobacter baylyi, and gram- ...
It may be used to treat certain strains of MRSA infection and a disease caused by drug resistant Acinetobacter. Both ... Urinary tract infections, rectal infections, and infections of the cervix caused by certain microbes Increase in sebaceous ... Minocycline is also used for other skin infections such as MRSA as well as Lyme disease, as the one pill twice daily 100 mg ... Rogers RL, Perkins J (September 2006). "Skin and soft tissue infections". Prim. Care. 33 (3): 697-710. doi:10.1016/j.pop. ...
... airborne acinetobacter infections in a ward were eliminated by the installation of a negative air ioniser-the infection rate ... Air ionisers have been used to eliminate the occurrence of air-borne bacterial infections and to reduce static electricity ... The frequency of nosocomial infections in British hospitals prompted the National Health Service (NHS) to research the ... McDowell, Natasha (3 January 2003). "Air ionisers wipe out hospital infections". The New Scientist (Daily news). Retrieved 24 ...
"Repeated airborne infections of the bacteria acinetobacter in an intensive care ward have been eliminated by the installation ... "Air ionisers wipe out hospital infections - 03 January 2003". New Scientist. 3 January 2003. Retrieved 23 February 2014. "For ...
... complicated intraabdominal infections, complicated urinary tract infections, and nosocomial respiratory tract infections. ... Acinetobacter, and Enterobacter. In addition, some Mycobacteria, including the bacteria that cause tuberculosis, are ... Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more ... In the past, the aminoglycosides have been used in conjunction with beta-lactam antibiotics in streptococcal infections for ...
... research into pathogens infecting combat wounds resulting in the first descriptions of acinetobacter baumannii infection in ... reflecting its focus on tropical infections of interest to the military such as malaria and Dengue fever. In 1947 NAMRU-2 ...
... and cannot be used to differentiate Acinetobacter from other common causes of infection. Most strains of Acinetobacter, except ... Acinetobacter species are a key source of infection in debilitated patients in the hospital, in particular the species ... Acinetobacter is frequently isolated in nosocomial infections, and is especially prevalent in intensive care units, where both ... Visca P, Seifert H, Towner KJ (December 2011). "Acinetobacter infection--an emerging threat to human health". IUBMB Life. 63 ( ...
"Acinetobacter baylyi as a Pathogen for Opportunistic Infection". Journal of Clinical Microbiology. 46 (9): 2938-2944. doi: ... Acinetobacter calcoaceticus is a bacterial species of the genus Acinetobacter. It is a nonmotile, gram negative coccobacillus. ... Acinetobacter calcoaceticus on www.ncbi.nlm.nih.gov Type strain of Acinetobacter calcoaceticus at BacDive - the Bacterial ... To identify other Acinetobacter species genotyping is required. A. calcoaceticus is a soil bacterium. It has been shown to be ...
They can cause infection in debilitated patients. DNA-DNA hybridization studies have been used to identify DNA groups (genomic ... formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Acinetobacter genomic species 13TU ... "Acinetobacter pittii and Acinetobacter nosocomialis among clinical isolates of the Acinetobacter calcoaceticus-baumannii ... characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii ...
... can cause bloodstream infection in neonates. LPSN bacterio.net Straininfo of Acinetobacter soli Dongyou Liu ... "Acinetobacter soli as a Cause of Bloodstream Infection in a Neonatal Intensive Care Unit". Journal of Clinical Microbiology. 49 ... Kim, D.; Baik, K. S.; Kim, M. S.; Park, S. C.; Kim, S. S.; Rhee, M. S.; Kwak, Y. S.; Seong, C. N. (2008). "Acinetobacter soli ... Acinetobacter soli is a Gram-negative, catalase-positive, oxidase-negative, strictly aerobic rod-shaped, nonmotile bacterium ...
Rathinavelu, S; Zavros, Y; Merchant, JL (June 2003). "Acinetobacter lwoffii infection and gastritis". Microbes and infection / ... It can cause infections in human hosts, particularly catheter-associated infections in immunocompromised patients. It has also ... Acinetobacter lwoffii, formerly known as Mima polymorpha or Acinetobacter calcoaceticus var. lwoffii, is a non-fermentative ... Type strain of Acinetobacter lwoffii at BacDive - the Bacterial Diversity Metadatabase. ...
"Blood stream infections caused by Acinetobacter ursingii in an obstetrics ward". Infection, Genetics and Evolution. 11 (1): 52- ... "Acinetobacter ursingii sp. nov. and Acinetobacter schindleri sp. nov., isolated from human clinical specimens". International ... and antimicrobial susceptibilities of Acinetobacter ursingii and Acinetobacter schindleri, two frequently misidentified ... Acinetobacter ursingii is a species of potentially pathogenic bacteria. Its type strain is LUH 3792T (= NIPH 137T = LMG 19575T ...
"Clinical characteristics of patients with Acinetobacter junii infection". Journal of Microbiology, Immunology, and Infection = ... nov., Acinetobacter haemolyticus sp. nov., Acinetobacter johnsonii sp. nov., and Acinetobacter junii sp. nov. and Emended ... Acinetobacter junii at the Encyclopedia of Life Type strain of Acinetobacter junii at BacDive - the Bacterial Diversity ... Bouvet, P. J. M.; Grimont, P. A. D. (1986). "Taxonomy of the Genus Acinetobacter with the Recognition of Acinetobacter ...
Gram-negative is mixed bacterial infection with the following organisms: Moraxella Alcaligenes Acinetobacter Pseudomonas ... Gram-negative toe web infection is a relatively common infection. It is commonly found on people who are engaged in athletic ... ISBN 0-7216-2921-0. "Gram-Negative Toe Web Infection". WebMD LLC. Retrieved 10 January 2013. "Gram-Negative Toe Web Infection: ... Gram-negative toe web infection is a cutaneous condition that often begins with dermatophytosis. ...
... has great relevance in the diagnosis of bacterial infections. Acinetobacter Bordetella Burkholderia Legionella Moraxella ...
... for multidrug-resistant Gram-negative bacterial infections such as multidrug-resistant Pseudomonas aeruginosa and Acinetobacter ... It is primarily used for the treatment of infections caused by multi-resistant bacteria including methicillin-resistant ... Matsumoto T (2014). "Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus ...
... infections Shigella species infections Acinetobacter species (formerly Mima species and Herellea species) infections ... doxycycline may be used to treat these infections caused by Gram-positive bacteria: Upper respiratory infections caused by ... doxycycline may be used to treat these infections caused by Gram-negative bacteria: Escherichia coli infections Enterobacter ... including methicillin-resistant Staphylococcus aureus infections Anthrax caused by Bacillus anthracis infection When penicillin ...
This infection-related cutaneous condition article is a stub. You can help Wikipedia by expanding it.. *v ... Chromobacteriosis infections are a cutaneous condition caused by chromobacteria characterized by fluctuating abscesses.:279 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Chromobacteriosis_infection&oldid=910443079" ...
Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection. ... A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects the lower urinary ... Urinary tract infections are the most frequent bacterial infection in women. They occur most frequently between the ages of ... Lower urinary tract infection is also referred to as a bladder infection. The most common symptoms are burning with urination ...
... inflammation and bacterial infection in the respiratory tract. Lactoferrin with hypothiocyanite has been granted orphan drug ... Acinetobacter species • Aeromonas hydrophila • Bacillus brevis • Bacillus Cereus • Bacillus megaterium • Bacillus subtilis • ... "Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice". J. Med. Microbiol ... weakened respiratory immune system against bacterial infection. Symptoms of cystic fibrosis include an inability to secrete ...
... baumannii is commonly involved in nosocomial infections, but few therapeutic options are available. Find out what there is to ... Acinetobacter baumannii is a gram-negative aerobic bacillus that primarily causes hospital-acquired infections affecting ... Table 2. Recommended doses of antimicrobials for severe A. baumannii infections Antibiotic. Loading dose. Daily dose. Dose on ... Table 1. Risk factors for development of A. baumannii infections in the ICU Prior colonization with A. baumannii ...
Patients with Acinetobacter pneumonias occurring in the context of an outbreak in the intensive care unit (IC... more ... Prolonged hospitalization or antibiotic therapy predisposes to Acinetobacter colonization. ... Diagnosis of acinetobacter baumannii infections. Int J Prev Med. 2012 Nov. 3(11):817. [Medline]. [Full Text]. ... An outbreak of acinetobacter infection associated with the use of a ventilator spirometer. Respir Care. 1980 Feb. 25(2):232-7. ...
Nosocomial bloodstream infections due to Acinetobacter baumannii, Acinetobacter pittii and Acinetobacter nosocomialis in the ... Acinetobacter infection. N Engl J Med. 2008;358:1271-81.PubMedCrossRefGoogle Scholar ... Intravenous minocycline: a review in Acinetobacter infections. Drugs. 2016;76:1467-76.PubMedCrossRefGoogle Scholar ... Existing treatment options for infections due to Acinetobacter are limited by a lack of robust efficacy and safety data along ...
This topic contains 2 study abstracts on Acinetobacter baumannii infection indicating that the following substances may be ... 1 Abstracts with Acinetobacter baumannii infection & Raspberry root Research. [x] Remove Focus on Raspberry root. Filter by ... 1 Problem Substances Researched for Acinetobacter baumannii infection Name. AC. CK. Focus. ... Diseases : Anthrax, Bacillus anthracis, Carbapenem-resistant Acinetobacter baumannii (CRAB), MRSA. Pharmacological Actions : ...
According to reports, health officials are probing into bacterial infections in the ... ... A premature baby died while four others were found sick at a New Jersey hospital because of a bacterial infection. ... Premature Baby Who Contracted Acinetobacter Baumannii Bacterial Infection Dies At New Jersey Hospital Michal Jarmoluk / Pixabay ... Wade said that acinetobacter is a hospital-acquired infection with no community transmission, which means that it does not pose ...
Acinetobacter baumannii causes a wide range of nosocomial infections. This pathogen is considered a threat to human health due ... A Phenome-Wide Association Study Uncovers a Pathological Role of Coagulation Factor X during Acinetobacter baumannii Infection ... Acinetobacter baumannii is a Gram-negative bacterium that is associated with hospital-acquired and ventilator-associated ... 2-Hydroxylation of Acinetobacter baumannii Lipid A Contributes to Virulence ...
Against infections with Pseudomonas aeruginosa or Acinetobacter baumannii isolates that are resistant to all antibiotics except ... Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter ... However, against infections with species resistant to all antibiotics, including polymyxins, novel combinations are the only ... For infections with antibiotic-susceptible strains of Pseudomonas aeruginosa, most studies have suggested that combination ...
Pneumonia was the most common infection (43.5%), followed by skin and soft tissue infections (20.4%). Acinetobacter baumannii ... Clinical experience of tigecycline treatment in infections caused by extensively drug-resistant Acinetobacter spp.. Moon SY1, ... There are few data on clinical experience of tigecycline in hospital-acquired pneumonia (HAP) and Acinetobacter spp. infection. ... Tigecycline can be considered as an alternative therapy in patients with HAP or infections caused by Acinetobacter spp., ...
HTF MI published a new industry research that focuses on Acinetobacter Infections Treatment market and delivers in-depth market ... Acinetobacter Infections Treatment Segment Market Analysis (by Type);. Chapter 7 and 8, to analyze the Acinetobacter Infections ... Acinetobacter Infections Treatment;. Chapter 12,13, 14 and 15, to describe Acinetobacter Infections Treatment sales channel, ... Specifications and Classification of Acinetobacter Infections Treatment, Applications of Acinetobacter Infections Treatment, ...
Recent Advances in the Immunopathogenesis of Acinetobacter baumannii Infection , IntechOpen, Published on: 2012-03-14. Authors ... Recent Advances in the Immunopathogenesis of Acinetobacter baumannii Infection. By Louis de Léséleuc and Wangxue Chen DOI: ... Medicine » Pulmonology » Pulmonary Infection, book edited by Amer Amal, ISBN 978-953-51-0286-1, Published: March 14, 2012 ...
The emergence of Acinetobacter infections in adult post-neurosurgical infections, multiple antibiotic resistant characteristics ... Of these 81 cases, Acinetobacter infection was found in 13 cases. Clinical and laboratory data of these Acinetobacter ... Adult Acinetobacter meningitis and its comparison with non-Acinetobacter gram-negative bacterial meningitis. ... A statistically significant difference between Acinetobacter meningitis and non-Acinetobacter GNBM included hydrocephalus and ...
A national alert was triggered in September 2003 when 4 hospitals reported clusters of A. baumannii infection with similar ... VEB-1 extended-spectrum beta-lactamase-producing Acinetobacter baumannii was responsible for an outbreak in hospitals in France ... From April 2003 through June 2004, 53 hospitals reported 290 cases of A. baumannii infection or colonization; 275 isolates were ... French Nosocomial Infection Early Warning Investigation and Surveillance Network ...
Acinetobacter community acquired pneumonia.. +6 More images of Acinetobacter infection with subscription ... Acinetobacter infection. Subscriber Sign In VisualDx Mobile Feedback Select Language Share Enter a Symptom, Medication, or ... Hospital outbreaks of multidrug-resistant Acinetobacter infections have been reported. A wide range of infections are possible ... 446156008 - Infection due to multidrug resistant Acinetobacter. Best Tests. Subscription Required. References. Subscription ...
Current State and Further Development of Animal Models of Serious Infections Caused by Acinetobacter baumannii and Pseudomonas ... Current State and Further Development of Animal Models of Serious Infections Caused by Acinetobacter baumannii and Pseudomonas ... Current State and Further Development of Animal Models of Serious Infections Caused by Acinetobacter baumannii and Pseudomonas ... Pathogenesis of Acinetobacter spp.: Resistance and Virulence Converge? (PDF - 2.6MB) - Robert A. Bonomo, M.D. ...
Clinical and Infection Control Implications - Volume 20 Issue 8 - Marie Eve Dy, Jill A. Nord, Vincent J. LaBombardi, Jay W. ... The Emergence of Resistant Strains of Acinetobacter baumannii: ... An outbreak of infections with Acinetobacter calcoaceticus in ... Typing of Acinetobacter baumannii isolated from hospital-acquired respiratory infections in a tertiary care centre in Southern ... Severe Acinetobacter baumannii Sepsis Is Associated with Elevation of Pentraxin 3. Infection and Immunity, Vol. 82, Issue. 9, p ...
... also known as Acinetobacter Baumannii Infection, is caused by the Acinetobacter baumannii bacteria. It can be spread by direct ... Skin or wound infection. Body systems harmed by Acinetobacter infection. An Acinetobacter baumannii infection can cause serious ... Acinetobacter infection, also known as Acinetobacter Baumannii Infection, is caused by the Acinetobacter baumannii bacteria. It ... Anyone can get an Acinetobacter baumannii infection. You are more likely to get an infection from Acinetobacter baumannii if ...
Background Multidrug resistant Acinetobacter baumanniiis one of the major infection agents causing nosocomial pneumonia. ... Acinetobacter baumannii is a widely spread opportunistic pathogen causing pneumonia, sepsis and soft tissue infections . A. ... Multidrug resistant Acinetobacter baumannii is one of the major infection agents causing nosocomial pneumonia. Therefore, new ... Blp1 protein shows virulence-associated features and elicits protective immunity to Acinetobacter baumannii infection. ...
... according to a new study published in the November issue of the American Journal of Infection Control. ... Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 percent of the rooms of patients ... Acinetobacter baumannii is a species of gram-negative, multidrug resistant bacteria that has caused outbreaks of infection in ... Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 percent of the rooms of patients ...
... and outcomes of older adults with Acinetobacter infection in community hospitals. The researchers investigated the microbiology ... According to the article in Clinical Infectious Diseases, "During this period, Acinetobacter prevalence increased 25 percent. ... MultidrugResistant Acinetobacter baumannii: An Emerging Pathogen among Older Adults in Community Hospitals and Nursing Homes. ... Infection Control Today is part of the Global Exhibitions Division of Informa PLC ...
... the two most common manifestations of clinical infections with this pathogen ... This unit describes basic protocols for infecting mice through intranasal and intraperitoneal routes with Acinetobacter ... tissue infection models for the study of Acinetobacter baumannii biology. Infection and Immunity, 76(8), 3577-3586. doi: ... Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice. Infection ...
Concurrent Outbreak of Multidrug-Resistant and Susceptible Subclones of Acinetobacter baumannii Affecting Different Wards of a ... Multiresistant Acinetobacter infections: a role of sulbactam combinations in overcoming an emerging worldwide problem. Clin ... Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case control study of adult burn patients ... 4.Simor, AE, Lee, M, Vearncombe, M, et al.An outbreak due to multire-sistant Acinetobacter baumannii in a burn unit: risk ...
Eighteen had osteomyelitis, 2 burn infection, and 3 deep wound infection. Primary therapy for these infections was directed ... Patients were followed up to 23 months after completing therapy, and none had recurrent infection with Acinetobacter species. ... Acinetobacter species have been prevalent during the 2003-2005 military operations in Iraq. Twenty-three soldiers wounded in ... Iraq and subsequently admitted to our facility from March 2003 to May 2004 had wound cultures positive for Acinetobacter ...
Body lice that fed on rabbits infused with each Acinetobacter species demonstrated a generalized infection. The body lice did ... Previous studies have reported the isolation of Acinetobacter baumannii from the body lice of homeless patients. To study how ... An increased mortality rate was observed between the second and third days post-infection; however, they remained infected for ... The lice excreted living Acinetobacter species within their feces. Only the louse strain of A. baumannii was pathogenic for the ...
The meropenem treatment outcome was similar in infections caused by the clinical and the heterogeneous isolates, irrespective ... baumannii isolates grown heterogeneously in the presence of meropenem and their virulence evaluated in experimental infections ... Acinetobacter baumannii may exhibit phenotypic heterogeneous growth under exposure to antibiotics. We investigated the in vitro ... isolates and the therapeutic efficacy of three meropenem dosing schemes was evaluated in a neutropenic murine thigh infection ...
... aeruginosa and Acinetobacter spp. Data correlating periodontal infection and P. aeruginosa or Acinetobacter spp. colonization ... Obana Y (1986) Pathogenic significance of Acinetobacter calcoaceticus: Analysis of experimental infection in mice. Microbiol ... Acinetobacter spp. are a major concern in nosocomial infections due to their rapid development of multi-drug resistance, ... of poor oral hygiene and periodontal infection. This study investigated the prevalence of P. aeruginosa and Acinetobacter spp. ...
EpidemiologyBacteremiaAbstractPneumoniaMortalityMicrobiologyRespiratoryPrevalenceColistinOutbreaksUrinaryBloodstream infectionsTreatment of Acinetobacter InfectionsStrains of Acinetobacter baumanniiSusceptibilityTigecyclineCause of nosocomialBacteriumMeningitisColonizationOpportunisticVirulenceWoundBacterial infectionsIntensive careEmergenceSpecies are oxidase-negativeVitroBaumaniiHealthcare-associatedTherapeuticHospital-acquired i
- We reviewed recent data about epidemiology of Acinetobacter baumannii , resistance mechanisms, and therapeutic options for severe infections caused by multidrug-resistant strains. (medscape.com)
- Garnacho-Montero J, Amaya-Villar R. Multiresistant Acinetobacter baumannii infections: epidemiology and management. (medscape.com)
- Outbreak of a multiply resistant Acinetobacter in a surgical intensive care unit: epidemiology and control. (medscape.com)
- Infection Control & Hospital Epidemiology, Vol. 22, Issue. (cambridge.org)
- The Epidemiology of Multidrug-Resistant Acinetobacter Baumannii Does the Community Represent a Reservoir? (cambridge.org)
- In their latest work, Sengstock and colleagues describe the epidemiology, resistance patterns, and outcomes of older adults with Acinetobacter infection in community hospitals. (infectioncontroltoday.com)
- Present at the public meeting were consultants with wide-ranging expertise in areas such as human and veterinary medicine, pharmaceutical and diagnostics manufacturing, animal husbandry, clinical microbiology, epidemiology, infectious diseases and infection control, and state and local public health officials. (cdc.gov)
- Epidemiology and Infection Control Implications ofAcinetobacter spp. (asm.org)
- We used amplified ribosomal DNA restriction analysis and pulsed-field gel electrophoresis to study further the molecular epidemiology of acinetobacters in our region. (asm.org)
- abstract = "The molecular epidemiology of fifteen clinical strains of Acinetobacter baumannii recovered from various clinical specimens from different wards during January to June, 2010 from a hospital in Nepal was evaluated. (edu.au)
- Ball pits used in children's physical therapy - similar to those made popular by restaurants catering to families - may contribute to germ transmission between patients, according to new research published in the American Journal of Infection Control, the journal of the Association for Professionals in Infection Control and Epidemiology, published by Elsevier. (news-medical.net)
- For infections with antibiotic-susceptible strains of Pseudomonas aeruginosa, most studies have suggested that combination therapy, usually with a beta -lactam antibiotic plus an aminoglycoside, is preferable for patients with bacteremia and neutropenia. (nih.gov)
- The incidence of bacteremia at military medical facilities caused by Acinetobacter baumannii has also increased ( 2 ). (cdc.gov)
- However, in hospitals, some strains, notably Acinetobacter baumannii will cause infections together with pneumonia and bacteremia ( bloodstream infection ). (soundhealthsolution.com)
- Acinetobacter baumannii is an important nosocomial pathogen that causes a range of diseases, including respiratory and urinary tract infections, meningitis, endocarditis, wound infections, and bacteremia. (grantome.com)
- bacteremia (6), and urinary tract infection (3). (blogspot.com)
- Acinetobacter bumannii causes different hospital-aquired infections, such as bacteremia, urinary tract infections, and secondary meningitis, but its prominent role is in hospital pneumonia, especially pneumonia of the upper respiratory tract of patients in intensive care units. (intjinfection.com)
- We evaluated the long-term effects of infection control interventions on the incidence densities of healthcare-associated infection (HAI) and CRA complex infection, and the rates of Acinetobacter calcoaceticus-Acinetobacter baumannii complex bacteremia (AB). (infectoforum.net)
- New research finds curcumin combined with a polyphenol in green tea and other foods and herbs will inhibit multi-drug resistant Acinetobacter baumannii - often at the root of hospital-acquried pneumonia infections. (greenmedinfo.com)
- Acinetobacter baumannii bacteria is known to cause pneumonia or serious blood or wound infections. (inquisitr.com)
- Acinetobacter baumannii is a Gram-negative bacterium that is associated with hospital-acquired and ventilator-associated pneumonia. (asm.org)
- Tigecycline has broad spectrum antimicrobial activity and is approved for complicated intra-abdominal infections, complicated skin and soft tissue infections, and community-acquired pneumonia. (nih.gov)
- There are few data on clinical experience of tigecycline in hospital-acquired pneumonia (HAP) and Acinetobacter spp. (nih.gov)
- A wide range of infections are possible with this organism, including bloodstream infections , pneumonia (occasionally even community-acquired pneumonia), urinary tract infections , and wound infections (wound infection in soldiers after traumatic injury have been reported). (visualdx.com)
- Patients present with symptoms compatible with the site of infection (for example, patients with pneumonia will have respiratory symptoms compatible with pneumonia). (visualdx.com)
- Acinetobacter community acquired pneumonia. (visualdx.com)
- Acinetobacter baumannii colonizes the respiratory tract, skin, urinary and gastrointestinal systems, and frequently leads to pneumonia, blood circulatory infection, and urinary system infection. (naturalpedia.com)
- Multidrug resistant Acinetobacter baumannii is one of the major infection agents causing nosocomial pneumonia. (springer.com)
- Community-acquired Acinetobacter pneumonia: a case report. (ajtmh.org)
- Objectives: In the intensive care setting, Acinetobacter baumannii causes ventilator-associated pneumonia and other nosocomial infections that are difficult to treat. (bezmialem.edu.tr)
- A person who has become infected with Acinetobacter bacteria may develop pneumonia-like symptoms. (brighthub.com)
- Acinetobacter causes a variety of diseases, ranging from pneumonia to serious blood or wound infections, and the symptoms vary depending on the disease. (bscnnursesolomonmpanga.com)
- Pneumonia: Pneumonia is an infection of the lungs. (soundhealthsolution.com)
- Your healthcare supplier could use an x-ray to seem for signs of pneumonia or different infections. (soundhealthsolution.com)
- In fact, A. baumannii is now responsible for up to 20% of all intensive care unit infections in some regions of the world with pneumonia being the most common presentation. (grantome.com)
- These infections may occur as outbreaks rather than isolated cases of nosocomial pneumonia. (medscape.com)
- The 2005 IDSA guidelines for hospital-acquired pneumonia discuss the role of Acinetobacter as a cause of nosocomial pneumonia. (medscape.com)
- Introduction: Ventilator Associated Pneumonia (VAP) is one of the most common nosocomial infections in the intensive care unit and leads to increase of mortality in affected patients. (ac.ir)
- This resistance often leads to devastatingly long delays in time to appropriate therapy and increased mortality for patients afflicted with Acinetobacter infections. (springer.com)
- Thirty-day mortality rate of HAP and Acinetobacter spp. (nih.gov)
- Ventricular infection due to XDR- Acinetobacter baumanii ( A. baumanii ) is the most severe complication after neurosurgery which associated with high morbidity and mortality. (panafrican-med-journal.com)
- Malfunction of ventriculo peritoneal (VP) shunt or external ventricular drainage (EVD) insertion closely related with post-neurosurgical infection which leads to longer hospitalization stay, higher costs, morbidity and mortality rate [ 1 , 2 ]. (panafrican-med-journal.com)
- Mortality and morbidity resulting from A baumannii infection relate to the underlying cardiopulmonary immune status of the host rather than the inherent virulence of the organism. (medscape.com)
- In one of the largest studies to measure the burden of antibiotic resistance in a low- or middle-income country, researchers at the Center for Disease Dynamics, Economics & Policy report that in-hospital mortality is significantly higher among patients infected with multi-drug resistant or extensively drug resistant pathogens including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii. (news-medical.net)
- A substantial number of reports received from hospitals across the world is warning of the alarming spread of antibiotic-resistant bacteria causing nosocomial infections (NIs), which has led to increases in both costs and mortality (1-3). (balkanmedicaljournal.org)
- Infections caused by imipenem-resistant Acinetobacter baumannii are associated with high mortality and morbidity. (clinicaltrials.gov)
- Acinetobacter baumannii has been increasingly reported in the outbreak of nosocomial infections in the intensive care units, which not only prolong the length of hospital stay but result in high attributable mortality. (clinicaltrials.gov)
- The researchers investigated the microbiology databases at Oakwood Healthcare System in Michigan (four hospitals with 632, 259, 199 and 168 beds) for clinical Acinetobacter cultures obtained from 2003 to 2008. (infectioncontroltoday.com)
- Differentiation of Acinetobacter species is difficult with the means typically available to most clinical microbiology laboratories, including commercial semiautomated identification systems. (mhmedical.com)
- Thapa, BK & Tribuddharat, C 2011, ' Emergence of oligoclonal Acinetobacter baumannii nosocomial infection in a Hospital in Nepal ', African Journal of Microbiology Research , vol. 5, no. 32, pp. 5872-5876. (edu.au)
- A group in the Department of Immunology, Microbiology and Parasitology at the UPV/EHU has conducted an in-depth study into the capacity to survive of the Acinetobacter baumannii bacterium as well as the strategies it uses to survive. (news-medical.net)
- Because routine identification in the clinical microbiology laboratory is not yet possible, Acinetobacter isolates are divided and grouped into three main complexes: Acinetobacter calcoaceticus-baumanii complex: glucose-oxidising nonhemolytic, (A. baumannii can be identified by OXA-51 typing) Acinetobacter lwoffii: glucose-negative nonhemolytic Acinetobacter haemolyticus: hemolytic Different species of bacteria in this genus can be identified using fluorescence-lactose-denitrification to find the amount of acid produced by metabolism of glucose. (wikipedia.org)
- Patients with Acinetobacter pneumonias occurring in the context of an outbreak in the intensive care unit (ICU) generally have a history of preceding contact with respiratory support monitors or equipment. (medscape.com)
- Nosocomial respiratory tract infection and colonization with Acinetobacter calcoaceticus. (medscape.com)
- An outbreak of Acinetobacter respiratory tract infection resulting from incomplete disinfection of ventilatory equipment. (medscape.com)
- Respiratory Bacterial infections due to Acinetobacter species are typically encountered in health care settings and can be particularly difficult to treat due to the propensity of the organism to incorporate multiple antibiotic resistance mechanisms. (visualdx.com)
- The oral cavity may be a major source of these respiratory pathogens, particularly in the presence of poor oral hygiene and periodontal infection. (scielo.br)
- The organism may be cultured from routine clinical specimens, cerebrospinal fluid, blood, respiratory secretions, peritoneal fluid, wound exudates, or urine.Imaging: Chest radiograph and CT scans are useful in defining the extent of a nosocomial infection by any organism or to rule out other causes of the patient's symptoms.Other tests: These tests would be related to the organ system involved. (medigoo.com)
- Colonization with Acinetobacter occurs on skin, wounds, and respiratory epithelium. (medigoo.com)
- Bloodstream infection, followed by respiratory tract and surgical wound infections, is the most signiﬁcant infection caused by A. baumannii ( 2 ). (jjmicrobiol.com)
- Most Acinetobacter isolates recovered from hospitalized patients, particularly those recovered from respiratory secretions and urine, represent colonization rather than infection. (medscape.com)
- When Acinetobacter infections occur, they usually involve organ systems that have a high fluid content (eg, respiratory tract, CSF, peritoneal fluid, urinary tract). (medscape.com)
- The presence of Acinetobacter isolates in respiratory secretions in intubated patients may represent colonization. (medscape.com)
- Acinetobacter pneumonias occur in outbreaks and are usually associated with colonized respiratory-support equipment or fluids. (medscape.com)
- Although this bacterium usually has low virulence, infected catheters cause a variety of infections and are often related to this respiratory system infection ( 9 ). (intjinfection.com)
- As environmental pollution and population aging intensify in China, there will be higher incidences of the main indications for Levofloxacin, for example, respiratory infection, urinary infection and intestinal infection. (researchandmarkets.com)
- The aim in this study was to investigate the spread status of antibiotic resistance genes, such as multiple beta-lactamase genes and aminoglycoside-modifying enzyme genes, from A. baumanii strains isolated from patients with lower respiratory tract infections (LRTIs). (mendeley.com)
- Prevalence of Pseudomonas aeruginosa and Acinetobacter spp. (scielo.br)
- This study investigated the prevalence of P. aeruginosa and Acinetobacter spp. (scielo.br)
- Despite the prevalence and interest in A. baumannii infections, there is relatively limited wellcontrolled scientific data to help the clinician select optimal empirical and subsequent targeted therapy for a variety of infections. (oup.com)
- Although the prevalence of carbapenemase-producing Acinetobacter baumannii (CP-AB) in Germany is still low an increasing number of outbreaks has been reported in recent years. (biomedcentral.com)
- Subsequently, the prevalence of carbapenem-resistant Acinetobacter infections has increased r. (biomedcentral.com)
- Conclusion: The elevated prevalence of VAP noscomial infection is alarming. (ac.ir)
- High Prevalence and Endemicity of Multidrug Resistant Acinetobacter spp. (hindawi.com)
- This study was a laboratory-based audit to determine the prevalence of Acinetobacter spp. (hindawi.com)
- Here we compare the efficacy of the peptide with that of imipenem and colistin in A. baumannii wound infections after burn injury. (elsevier.com)
- Colistin, the most commonly used agent for acinetobacter, can cause severe kidney and neurological damage and is considered an antibiotic of last resort. (pbs.org)
- Antimicrobials drugs frequently reported as active against Acinetobacter spp include carbapenems, colistin, ampicillin/sulbactam, amikacin, rifampin and tetracyclines and currently carbapenens are considered the main antimicrobial treatment. (usp.br)
- Outbreaks of Acinetobacter infections typically occur in intensive care units and healthcare settings housing very ill patients. (bscnnursesolomonmpanga.com)
- While there are many types or "species" of Acinetobacter and all can cause human disease, Acinetobacter baumannii accounts for about 80% of reported infections.Outbreaks of Acinetobacter infections typically occur in intensive care units and healthcare settings housing very ill patients. (medigoo.com)
- Outbreaks of Acinetobacter infections, often caused by multiresistant strains, have been widely reported, commonly in intensive care units (ICUs) in North America and Europe. (asm.org)
- In smaller, city hospitals like Nashville General, outbreaks of acinetobacter can cripple the ICU. (pbs.org)
- It may also cause urinary tract and skin and soft-tissue or wound infections. (naturalpedia.com)
- Hospitalized patients, especially very ill patients on a ventilator, those with a prolonged hospital stay, those who have open wounds, or any person with invasive devices like urinary catheters are also at greater risk for Acinetobacter infection. (bscnnursesolomonmpanga.com)
- It may additionally cause urinary tract and wound infections. (soundhealthsolution.com)
- Urinary tract infection: A urinary tract infection (UTI) is an infection of the kidneys, ureters, or bladder. (soundhealthsolution.com)
- Similarly, Acinetobacter urinary tract infections are clinically indistinguishable from catheter-associated bacteremias caused by other aerobic gram-negative bacilli. (medscape.com)
- Acinetobacter colonization is particularly common in patients who are intubated and in those who have multiple intravenous lines or monitoring devices, surgical drains, or indwelling urinary catheters. (medscape.com)
- Urinary tract infections were not included. (usp.br)
- 102 patients had bloodstream infections at facilities treating U.S. military personnel injured in Iraq or Afghanistan from January 1, 2002, through August 31, 2004. (mhmedical.com)
- Currently, reports on persistent bloodstream infections caused by A. baumannii are rare. (jjmicrobiol.com)
- CRE is primarily a nosocomial infection which accounts for 4% of bloodstream infections (NHSN 2012). (oregon.gov)
- Acinetobacter baumannii accounted for 1.8% of all healthcare-associated infections reported to the National Healthcare Safety Network (NHSN) during 2009-2010, but 6.6% of ventilator-associated pneumonias (VAPs), and 2.2% of central line-associated bloodstream infections (CLABSI). (oregon.gov)
- Treatment of Acinetobacter infections. (medscape.com)
- A retrospective review was conducted of the medical records of 29 sequential patients who received tigecycline for treatment of Acinetobacter infections. (blogspot.com)
- Data from more studies are needed before tigecycline can be recommended for the treatment of Acinetobacter infections. (blogspot.com)
- Representatives (n = 31) of outbreak strains of Acinetobacter baumannii from five countries fell into three clear groups, designated Groups 1-3, based on their ompA (outer-membrane protein A), csuE (part of a pilus assembly system required for biofilm formation) and bla(OXA-51-like) (the intrinsic carbapenemase gene in A. baumannii) gene sequences. (nih.gov)
- Selecting appropriate empiric and definitive antibacterial therapy for Acinetobacter is further complicated by the lack of reliability in commercial antimicrobial susceptibility testing devices and limited breakpoint interpretations for available agents. (springer.com)
- A national alert was triggered in September 2003 when 4 hospitals reported clusters of A. baumannii infection with similar susceptibility profiles. (uptodate.com)
- Clonally related strains of Acinetobacter that differ in susceptibility patterns may coexist within a single hospital, dependent on the selective pressure related to antibiotic exposure. (cambridge.org)
- This strategy is based on the fact that all bacterial pathogens require nutrient metal in order to colonize their hosts, and alterations in dietary metal levels profoundly affect susceptibility to infection. (grantome.com)
- The aim of this study was to identify the etiologic agents of VAP infections in intensive care unit and antibiotic susceptibility determination of isolated bacteria. (ac.ir)
- Few (100) randomly selected isolates of Acinetobacter baumannii ( A. baumannii) were tested for imipenem, meropenem, and polymyxin B susceptibility by minimum inhibitory concentration (MIC) and for the presence of class A and B carbapenemases by multiplex PCR. (hindawi.com)
- Tigecycline can be considered as an alternative therapy in patients with HAP or infections caused by Acinetobacter spp. (nih.gov)
- Tigecycline has in vitro activity against Acinetobacter spp. (blogspot.com)
- However, the low serum level and bacteriostatic nature of tigecycline hamper its application in blood stream infection, one of the most common presentations of A. baumannii infections. (clinicaltrials.gov)
- A. baumannii is a major cause of nosocomial infections affecting mainly to debilitating patients in the ICU, although the spread to regular wards and to long-term care facilities is increasing. (medscape.com)
- In the hospital setting, Acinetobacter species are an important cause of nosocomial infection, yet these infections were rarely encountered in our facility until we began observing them in soldiers with infected wounds. (cdc.gov)
- Neurosurgically related nosocomial Acinetobacter baumannii meningitis: report of two cases and literature review. (medscape.com)
- Meningitis is an infection of the brain or medulla spinals. (soundhealthsolution.com)
- I keep reading that it's rare for sinus infection to cause meningitis, but it happened to me. (healthtap.com)
- Had meningitis from bad sinus infection. (healthtap.com)
- Very unusual for a sinus infection to transform into meningitis . (healthtap.com)
- Think I may have a sinus infection and if I do then I've had it for a while now, how rare is it to get meningitis from this? (healthtap.com)
- What are the chances that an untreated sinus infection would turn into meningitis? (healthtap.com)
- The germ may enter through the nasal passages, but it would be rare for anyone with a sinus infection to transform into meningitis. (healthtap.com)
- What's the likelihood of getting meningitis from a potentially untreated sinus infection of one month? (healthtap.com)
- Yes it is possible for a bad sinus infection to lead to meningitis . (healthtap.com)
- What are chances of getting sinus infection again that turns into meningitis? (healthtap.com)
- Prolonged hospitalization or antibiotic therapy predisposes to Acinetobacter colonization. (medscape.com)
- Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A . mBio, Vol. 9, Issue. (cambridge.org)
- Further, the study found that patients with a recent history of MDR-AB colonization or infection were not significantly more likely than those with a remote history of MDR-AB to contaminate their environment. (infectioncontroltoday.com)
- The authors note several potential limitations including small sample size, lack of a comparison group, and the inability to determine which came first: environmental contamination or patient colonization/infection. (infectioncontroltoday.com)
- In general, first-, second-, and third-generation cephalosporins, macrolides, and penicillins have little or no anti- Acinetobacter activity, and their use may predispose to Acinetobacter colonization. (medscape.com)
- Care must be exercised in determining whether the isolate is due to colonization or is truly causing infection. (medscape.com)
- Acinetobacter species are can be transmitted to patients because of their persistence on environmental surfaces and because of colonization of the hands of healthcare workers. (medscape.com)
- The relationship between opportunistic pulmonary fungal infections and CD4 count levels among HIV-seropositive patients in Calabar, Nigeria. (blogspot.com)
- 1. Define the terms Opportunistic, Nosocomial and Iatrogenic infections. (brainscape.com)
- Opportunistic: an infection that occurs in a compromised host by an organism (bacteria, fungus, parasite or virus), which does not usually infect a "normal" host. (brainscape.com)
- Moreover, the blp1 gene is required for the establishing of A. baumannii virulence phenotype in nematode and murine infection models. (springer.com)
- Acinetobacter species have low virulence but are capable of causing infection in organ transplants and febrile neutropenia. (medscape.com)
- This is an infection caused by Staphylococcus aureus - and it often is quite dangerous because the organism, the 'germ' has alot of virulence to it. (healthtap.com)
- Twenty-three soldiers wounded in Iraq and subsequently admitted to our facility from March 2003 to May 2004 had wound cultures positive for Acinetobacter calcoaceticus-baumannii complex. (cdc.gov)
- Eighteen had osteomyelitis, 2 burn infection, and 3 deep wound infection. (cdc.gov)
- A. baumannii is the most medically relevant member of the Acb complex since it has been associated with hospital infections as well as community-acquired and injury infections, particularly those caused after natural disasters or wound infections in military personnel deployed to Iraq and Afghanistan ( 10 ). (asm.org)
- In this work, we isolated and assembled a five-member cocktail of wild phages against Acinetobacter baumannii and demonstrated therapeutic efficacy in a mouse full-thickness dorsal infected wound model. (asm.org)
- The cocktail lowers the bioburden in the wound, prevents the spread of infection and necrosis to surrounding tissue, and decreases infection-associated morbidity. (asm.org)
- Other signs of this bad bacterial infection are redness around a wound and the presence of pus. (brighthub.com)
- Skin or wound infection: Any skin gap or wound will get infected with the germ. (soundhealthsolution.com)
- Traumatic wound infections can be treated with minocycline. (medigoo.com)
- Ultraviolet C light for Acinetobacter baumannii wound infections in mice: Potential use for battlefield wound decontamination? (lww.com)
- Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. (medscape.com)
- According to reports, health officials are probing into bacterial infections in the neonatal intensive care unit of University Hospital in Newark following the death of the premature baby in late September. (inquisitr.com)
- Results of this study suggest that the extract alone of Peganum harmala and Heracleum persicum may be useful to treat bacterial infections. (intjinfection.com)
- They are no all bacterial infections . (healthtap.com)
- Amikacin Amphotericin B Ceftobiprole Ceftaroline Carbapenems (such as imipenem/cilastatin) - used as drug of last resort for a variety of different bacterial infections. (wikipedia.org)
- Patients who are immunosuppressed, have diabetes, or who are hospitalized (especially in intensive care units) are at increased risk for this infection. (visualdx.com)
- Acinetobacter baumannii causes severe infections that primarily affect intensive care unit (ICU) patients. (jidc.org)
- Bloodstream infection due to Acinetobacter baumannii is characterized as a nosocomial infection, particularly occurs in intensive care units (ICUs). (jjmicrobiol.com)
- Multiple factors tend to increase the risk for acquiring an Acinetobacter infection, including prior antibiotic exposure, intensive care unit admission, use of a central venous catheter, and mechanical ventilation or hemodialysis use. (medscape.com)
- Acinetobacter commonly colonizes patients in the intensive care setting. (medscape.com)
- Univariate analysis suggested that mechanical ventilation, indwelling catheter, cancer patients, length of hospitalization in intensive care unit (ICU) ≥15 d, Acute Physiology and Chronic Health Evaluation (APACHE) II score, combined using antibiotic before isolation of AB and use of third-lines cephalosporins were associated with the development of MDR-AB healthcare-associated infections. (springer.com)
- with healthcare associated infections (HCAI) in intensive care units (ICU) is alarming. (hindawi.com)
- In July 2010, a team in New Delhi reported a cluster of three cases of Acinetobacter baumannii bearing blaNDM-1 that were found in the intensive care unit of a hospital in Chennai, India, in April 2010. (wikipedia.org)
- Previous reports of community-associated Acinetobacter infections have lacked clear case definitions and assessment of healthcare-associated (HCA) risk factors. (cambridge.org)
- Additionally, these factors also facilitate easy transmission of MDROs implicated in various healthcare associated infections (HCAI). (hindawi.com)
- Staphylococcus aureus was the most common healthcare-associated infection (HAI) reported to the National Healthcare Safety Network (NHSN) during 2009-2010, accounting for 15.6% of all infections, 12.3% of central line-associated blood stream infections, and 30.4% of surgical site infections. (oregon.gov)
- E. faecium and E. faecalis accounted for 4.1% and 6.8% of all healthcare-associated infections (HAI) reported to the National Healthcare Safety Network during 2009-2010. (oregon.gov)