Infections with bacteria of the genus ACINETOBACTER.
A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.
A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A species of gram-negative, aerobic bacteria found in soil and water. Although considered to be normally nonpathogenic, this bacterium is a causative agent of nosocomial infections, particularly in debilitated individuals.
Substances that reduce the growth or reproduction of BACTERIA.
Any infection which a patient contracts in a health-care institution.
A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.
The study of the heart, its physiology, and its functions.
A medical specialty concerned with the diagnosis and treatment of SLEEP WAKE DISORDERS and their causes.
The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.
A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).
A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.
A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.
A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.
Amputation or separation at a joint. (Dorland, 28th ed)
Hostile conflict between organized groups of people.
The portion of the leg in humans and other animals found between the HIP and KNEE.
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
Oral tissue surrounding and attached to TEETH.

Acinetobacter bacteremia in Hong Kong: prospective study and review. (1/737)

The epidemiological characteristics of 18 patients with acinetobacter bacteremia were analyzed. Patients (mean age, 55.5 years) developed bacteremia after an average of 14.1 days of hospitalization. Fifteen of 16 patients survived bacteremia caused by Acinetobacter baumannii. Cultures of blood from the remaining two patients yielded Acinetobacter lwoffii. Most patients (78%) resided in the general ward, while four patients (22%) were under intensive care. Genotyping by arbitrarily primed polymerase chain reaction analysis and the temporal sequence of isolation were more useful than phenotyping by antimicrobial susceptibility in the determination of the source of bacteremia, and the intravascular catheter was the leading infection source (39% of cases). The possibility of an association of glucose with the pathogenesis of acinetobacter infection was raised.  (+info)

Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case-control study of adult burn patients. (2/737)

Risk factors for Acinetobacter baumannii bloodstream infection (BSI) were studied in patients with severe thermal injury in a burn intensive care unit where A. baumannii was endemic. Of 367 patients hospitalized for severe thermal injury during the study period, 29 patients with nosocomial A. baumannii BSI were identified (attack rate, 7.9%). Cases were compared with 58 matched controls without A. baumannii BSI. The overall mortality rate was 31% among cases and 14% among controls; only two deaths (7%) were considered directly related to A. baumannii BSI. Molecular typing of A. baumannii blood isolates by means of randomly amplified polymorphic DNA analysis and pulsed-field gel electrophoresis revealed the presence of three different strain types. Multivariate analysis showed that female gender (P = .027), total body surface area burn of > 50% (P = .016), prior nosocomial colonization with A. baumannii at a distant site (P = .0002), and use of hydrotherapy (P = .037) were independently associated with the acquisition of A. baumannii BSI in burn patients. These data underscore the need for effective infection control measures for this emerging nosocomial problem.  (+info)

Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii. (3/737)

From March 1995 to March 1997, sulbactam was prospectively evaluated in patients with non-life-threatening multiresistant Acinetobacter baumannii infections. During this period, 47 patients were treated with sulbactam; of them, five were excluded because they had received < or =48 h of sulbactam therapy. A total of 42 patients, 27 males and 15 females with a mean age of 60+/-15 years, were finally evaluated. Infections were as follows: surgical wound, 19; tracheobronchitis, 12; urinary tract, 7; catheter-related bacteraemia, 2; and pneumonia, 2. Eighteen patients received intravenous sulbactam alone (1 g every 8 h) and 24 patients received intravenous sulbactam/ampicillin (1 g:2 g every 8 h) with no major adverse effects. Of the 42 patients, 39 improved or were cured and showed A. baumannii eradication and one patient had persistence of wound infection after 8 days of sulbactam/ampicillin requiring surgical debridement. Two patients died after 3 days of therapy (one of the deaths was attributable to A. baumannii infection). The in-vitro activity of the sulbactam/ampicillin combination was by virtue of the antimicrobial activity exhibited by sulbactam. Killing curves showed that sulbactam was bacteriostatic; no synergy was observed between ampicillin and sulbactam. Our results indicate that sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem.  (+info)

Identification of Acinetobacter baumannii strains with monoclonal antibodies against the O antigens of their lipopolysaccharides. (4/737)

Despite the emergence of Acinetobacter baumannii strains as nosocomial pathogens, simple methods for their phenotypic identification are still unavailable. Murine monoclonal antibodies specific for the O-polysaccharide moiety of the lipopolysaccharide (LPS) of two A. baumannii strains were obtained after immunization with heat-killed bacteria. The monoclonal antibodies were characterized by enzyme immunoassay and by Western and dot blot analyses and were investigated for their potential use for the identification of A. baumannii strains. The antibodies reacted with 46 of the 80 A. baumannii clinical isolates that were investigated, and reactivity was observed with 11 of 14 strains which were isolated during outbreaks in different northwestern European cities; no reactivity was observed with Acinetobacter strains of other genomic species, including the closely related genomic species 1 (Acinetobacter calcoaceticus), 3, and 13 sensu Tjernberg and Ursing, or with other gram-negative bacterial strains. The results show that O-antigen-specific monoclonal antibodies such as the ones described are convenient reagents which can be used to identify Acinetobacter strains in clinical and research laboratories.  (+info)

Some immunological properties of lipopolysaccharide from Acinetobacter baumannii. (5/737)

Acinetobacter baumannii, mainly biotype 9, is an important nosocomial opportunist pathogen in Chile and other countries. The biological basis of its virulence and prevalence is still unknown. As lipopolysaccharide (LPS) is often associated with virulence, some biological properties of purified LPS from seven nosocomial isolates, comprising four isolates of A. baumannii biotype 9, two isolates of biotype 8 and one isolate of biotype 1, were investigated. LPS was extracted and purified from each isolate by the hot phenol-water method, and its ability to elicit a mitogenic response and to induce the synthesis of a tumour necrosis factor (TNF-alpha) in mouse spleen cells was determined. Activity was evaluated in vivo by determining the splenic index in comparison with LPS from Salmonella Typhimurium. All seven LPS samples were mitogenic on the basis of cellular proliferation experiments and six induced synthesis of TNF-alpha. Similar results were obtained in in-vivo experiments in which LPS induced spleen cell growth, as shown by determination of the splenic index. These results suggest that the LPS of A. baumannii might contribute to the pathogenic properties of this species.  (+info)

Use of a murine O-antigen-specific monoclonal antibody to identify Acinetobacter strains of unnamed genomic species 13 Sensu Tjernberg and Ursing. (6/737)

A monoclonal antibody against the O-antigenic polysaccharide chain of the lipopolysaccharide (LPS) of Acinetobacter strains belonging to the unnamed genomic species 13 Sensu Tjernberg and Ursing (13TU) was obtained after immunization of BALB/c mice with heat-killed bacteria and was characterized by enzyme immunoassay and Western blot analysis, by use of LPS and proteinase K-treated bacterial lysates, analyses in which the antibody was shown to be highly specific for the homologous antigen. In addition, when tested in dot and Western blots, reactivity was observed with 9 of 18 Acinetobacter strains of genomic species 13TU which had been isolated in Germany and Denmark; no reactivity was observed with strains of other genomic species, including the closely related genomic groups 1 (A. calcoaceticus), 2 (A. baumannii), and 3 (unnamed), or with other gram-negative bacteria. The antibody described here represents a convenient reagent for the simple, economical, and accurate differentiation of clinical isolates of genomic species 13TU from other Acinetobacter strains. Although the antibody does not identify all isolates of this genomic group, it is evident that it will be a useful reagent in the development of a serotyping scheme for clinical laboratories.  (+info)

Genotypic and phenotypic similarity of multiresistant Acinetobacter baumannii isolates in the Czech Republic. (7/737)

The diversity of 103 clinical isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex obtained between 1991 and 1997 from 17 Czech hospitals was studied by ribotyping, biotyping, plasmid profiling and antibiotic susceptibility testing. According to the EcoRI ribotypes, all but one of these isolates were identified to the DNA group level: 77 isolates were allocated to DNA group 2 (A. baumannii), 14 to DNA group 3, 10 to DNA group 13 sensu Tjernberg and Ursing and one to DNA group 1 (A. calcoaceticus). In total, 50 different EcoRI ribotypes and 10 biotypes were observed. Plasmids were found in 92% of the isolates and a high variability in plasmid profiles was found in isolates of the same DNA group. The combination of typing profiles allowed two predominant groups (termed A and B) to be distinguished among the A. baumannii isolates (37 and eight isolates, respectively) that shared a specific ribotype and were highly similar in other properties. These two groups comprised both sporadic and outbreak isolates and were found in most localities. Group A and B isolates were markedly more resistant to antibiotics than most of the remaining isolates, thus representing 85% of all multiresistant isolates. The features of groups A and B corresponded to those of two epidemic clones identified recently among hospital strains in north-western Europe.  (+info)

In vivo efficacies of combinations of beta-lactams, beta-lactamase inhibitors, and rifampin against Acinetobacter baumannii in a mouse pneumonia model. (8/737)

The effects of various regimens containing combinations of beta-lactams, beta-lactam inhibitor(s), and rifampin were assessed in a recently described mouse model of Acinetobacter baumannii pneumonia (M. L. Joly-Guillou, M. Wolff, J. J. Pocidalo, F. Walker, and C. Carbon, Antimicrob. Agents Chemother. 41:345-351, 1997). Two aspects of the therapeutic response were studied: the kinetics of the bactericidal effect (treatment was initiated 3 h after intratracheal inoculation, and bacterial counts were determined over a 24-h period) and survival (treatment was initiated 8 h after inoculation, and the cumulative mortality rate was assessed on day 5). Two clinical strains were used: a cephalosporinase-producing strain (SAN-94040) and a multiresistant strain (RCH-69). For SAN-94040 and RCH-69, MICs and MBCs (milligrams per liter) were as follows: ticarcillin, 32, 64, 256, and >256, respectively; ticarcillin-clavulanate, 32, 64, and 512, and >512, respectively; imipenem, 0.5, 0.5, 8, and 32, respectively; sulbactam, 0.5, 0.5, 8, and 8, respectively; and rifampin, 8, 8, 4, and 4, respectively. Against SAN-94040, four regimens, i.e., imipenem, sulbactam, imipenem-rifampin, and ticarcillin-clavulanate (at a 25/1 ratio)-sulbactam produced a true bactericidal effect (>/=3-log10 reduction of CFU/g of lung). The best survival rate (i.e., 93%) was obtained with the combination of ticarcillin-clavulanate-sulbactam, and regimens containing rifampin provided a survival rate of >/=65%. Against RCH-69, only regimens containing rifampin and the combination of imipenem-sulbactam had a true bactericidal effect. The best survival rates (>/=80%) were obtained with regimens containing rifampin and sulbactam. These results suggest that nonclassical combinations of beta-lactams, beta-lactamase inhibitors, and rifampin should be considered for the treatment of nosocomial pneumonia due to A. baumannii.  (+info)

Acinetobacter Infections - Pipeline Review, H1 2017 Summary Latest Pharmaceutical and Healthcare disease pipeline guide Acinetobacter Infections - Pipeline
Bacterial infections due to Acinetobacter species are typically encountered in health care settings and can be particularly difficult to treat due to the propensity of the organism to incorporate multiple antibiotic resistance mechanisms. Hospital outbreaks of multidrug-resistant Acinetobacter infections have been reported. A wide range of infections are possible with this organism, including bloodstream infections, pneumonia (occasionally even community-acquired pneumonia), urinary tract infections, and wound infections (wound infection in soldiers after traumatic injury have been reported ...
Infection with antibiotic-resistant Acinetobacter spp. is an increasing problem in critical care environments worldwide. Acinetobacter spp. are known to produce an insulin-cleaving protease. We hypothesized that infection with Acinetobacter spp. was associated with the acquisition of glucose intolerance in burn patients. Data were collected prospectively on all 473 patients admitted to the Burns Centre between January 2002 and March 2003. A total of 3.4% of patients acquired glucose intolerance during admission. Patients with Acinetobacter spp. infection were 9.8 times more likely to develop glucose intolerance than those without the infection (P | .0001). The association persisted after controlling for TBSA (P | .001). In patients with deep Acinetobacter spp. infection, 47% had glucose intolerance, compared with 12% in those with infection of the burn only (P = .03). In patients with pre-existing diabetes mellitus, 27% developed Acinetobacter spp. infection compared with only 8.5% of patients without
Clinical features and outcomes of Acinetobacter species and Pseudomonas aeruginosa. Presented at the 46th Interscience infections due buy Xanax tablets online UK multidrug resistant baumannii Ab bloodstream infections BSI. Antimicrob Agents Chemother 200751376 378 391 Fournier PE. Clin Infect Dis 1996221026 1032 Carey RB, Banerjee SN. baumannii correlated with an increased 1999 Marmara earthquake. Surveillance cultures and duration of carriage of multidrug resistant Acinetobacter. Seasonal variation of Acinetobacter infections Clin Microbiol Rev 200619257. J Clin Microbiol 2006443623 3627 of resistance to tigecycline has. Crit Care Med 2005331136 1140 of broad spectrum antibiotics. References Schreckenberger PC, Daneshvar with multidrug resistant Pseudomonas aeruginosa. Presented at the 46th Interscience outbreaks of acinetobacter infections, most even more limited. PLoS Genet 20062e7 e7 of Acinetobacter spp. Source Information From Medical for nonsusceptibility in Acinetobacter baumannii. 79 An ...
HTF MI published a new industry research that focuses on Acinetobacter Infections Treatment market and delivers in-depth market analysis and future prospec
outbreaks of carbapenem-resistant A. baumannii infection occurred in a hospital in New York City. Subsequently, numerous other hospitals in the United States and South America have had outbreaks of carbapenem-resistant A. baumannii. The incidence of infections with A. baumannii among military personnel from the United States and Canada has increased since 2002; 102 patients had bloodstream infections at facilities treating U.S. military personnel injured in Iraq or Afghanistan from January 1, 2002, through August 31, 2004. An epidemiologic investigation revealed that A. baumannii could be grown from environmental sites in field hospitals and that the environmental strains were closely related genotypically to clinical isolates. A. baumannii strains from injured military personnel from the United States and the United Kingdom were also genotypically related; this finding provided further evidence that A. baumannii was being acquired in field hospitals.. ...
Acinetobacter spp. are a diverse group of Gram-negative bacteria frequently implicated in nosocomial infections. Genotypic methods have been instrumental in studying Acinetobacter, but few offer high resolution, rapid turnaround time, technical ease and high inter-laboratory reproducibility, which has hampered understanding of disease incidence, transmission patterns and diversity within this genus. Here, we further evaluated multilocus PCR electrospray ionization/ mass spectrometry (PCR/ESI-MS), a method that is simple and robust, and provides both species characterization and strain-level resolution of Acinetobacter spp. on a single platform. We examined 125 Acinetobacter isolates from 21 hospitals, laboratories and medical centres spanning four counties in Arizona, USA, using PCR/ESI-MS. We compared PCR/ESI-MS with an in-house amplified fragment length polymorphism (AFLP) genotyping scheme. PCR/ESI-MS demonstrated that Acinetobacter spp. from Arizonan hospitals had similar species and strain
Prompt detection of metallo-beta-lactamase (MBL) producing isolates is necessary to prevent their dissemination. Frequency of MBLs producing strains among multidrug resistant (MDR) Acinetobacter species and Pseudomonas aeruginosa was evaluated in critical care Patients using imipenem-EDTA disk method. One hundred MDR Acinetobacter spp. and 42 Pseudomonas aeruginosa were checked for MBL production, from January to June 2001. MBL was produced by 96.6 % of imipenem-resistant Acinetobacter isolates, whereas 100% imipenem-resistant Pseudomonas aeroginosa isolates were MBL producers. Carbapenem resistance in MDR Acinetobacter spp. and Pseudomonas aeruginosa isolates in this study was due to MBLs. This calls for strict infection control measures to prevent further dissemination.
War wound infection and osteomyelitis caused by multidrug-resistant (MDR) Acinetobacter species have been prevalent during the 2003-2005 military operations in Iraq. Twenty-three soldiers wounded in Iraq and subsequently admitted to our facility from March 2003 to May 2004 had wound cultures positive for Acinetobacter calcoaceticus-baumannii complex. Eighteen had osteomyelitis, 2 burn infection, and 3 deep wound infection. Primary therapy for these infections was directed antimicrobial agents for an average of 6 weeks. All soldiers initially improved, regardless of the specific type of therapy. Patients were followed up to 23 months after completing therapy, and none had recurrent infection with Acinetobacter species. Despite the drug resistance that infecting organisms demonstrated in this series, a regimen of carefully selected extended antimicrobial-drug therapy appears effective for osteomyelitis caused by MDR Acinetobacter spp.
Teck Wee Boo, Molecular characterisation of carbapenem resistance of Acinetobacter species in an Irish tertiary care hospital, [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2010, pp 377 ...
These insights are helpful for CEOs, VPs, stakeholders, and investors to save their time and gain overview of the industry. It helps them to weigh up opportunities and take necessary steps to gain strong position.
Acrônimos com ACINETOBACTER. As definições de siglas Acinetobacter. As definições de acrónimo Acinetobacter. Sigla Acinetobacter significa para. Além de encontrar siglas. Encontre o que significam as siglas!
海词词典,最权威的学习词典,专业出版acinetobacter winogradskyii是什么意思,acinetobacter winogradskyii的用法,acinetobacter winogradskyii翻译和读音等详细讲解。海词词典:学习变容易,记忆很深刻。
海词词典,最权威的学习词典,专业出版acinetobacter baummanii是什么意思,acinetobacter baummanii的用法,acinetobacter baummanii翻译和读音等详细讲解。海词词典:学习变容易,记忆很深刻。
Qpex Biopharma to Provide First Public Presentations of Preclinical Data on the Novel Ultra-Broad-Spectrum Beta-lactamase Inhibitor QPX7728 for IV and Oral Products at 2019 ASM Microbe Meeting. ​. SAN DIEGO, June 13, 2019 - Qpex Biopharma today announced that preclinical data on its investigational beta-lactamase inhibitor QPX7728 will be featured in several presentations at the 2019 ASM Microbe Meeting to be held June 20-24 in San Francisco, CA.. ​. We are pleased to be making the first public presentations on our next generation beta- lactamase inhibitor QPX7728 that exceeds the profile of other agents recently approved or in clinical development. said Michael Dudley, PharmD, President and CEO of Qpex Biopharma. QPX7728s potent inhibition of major beta-lactamases, including metallo enzymes, and activity in multi-drug resistant Acinetobacter as well as Enterobacteriaceae and Pseudomonas aeruginosa represents a major advance in the field. QPX7728 has the potential for use in combination ...
Results: Out of 17,827 samples, 2,816 were culture positive. 122 of the isolates tested positive for Acinetobacter spp.and 81.1% of the isolates belonged to Acinetobacterbaumannii. Most of the infection occurred in the age group of 21-40 y and predominantly in female patients (female, male ratio 1.9:1).General wards contributed to 54.9% of the Acinetobacter infection, followed by ICU(27%) and OPD(18%). Maximum isolates were recovered from urine(34.4%) and endotracheal secretions(29.5%).60.7% of the Acinetobacterspp were multidrug-resistant(MDR)i.e. resistant to more than 3 antibiotic group.In our study, most Acinetobactersppwere resistant to penicillin(46-100%), third and fourth generation cephalosporin (36-61.5%), carbapenems (34.4-82.8%)and quinolones(39.3-46.7%). None of the isolates were resistant to colistin. 93.4% ofisolates were sensitive to tigecycline and 87.7% sensitive to amikacin. ...
ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.. About ASM , Contact Us , Press Room. ASM is a member of. ...
Resistência aos antibióticos β-lactâmicos em isolados clínicos de Acinetobacter spp : caracterização molecular de novas carbapenemases, IMP-5 e OXA-33, e estudo da relação clonal entre os isolados resistentes ao ...
Bacterial infection is a major cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Streptococcus pneumoniae (SP) and Haemophilus influenza (HI) are the most frequently encountered.. Objectives: Studying the relation between the bacteriologic etiology of AECOPD and severity of the disease.. Methods: This is a retrospective study of patients with COPD hospitalised for AECOPD and whose bacteriological sputum was used to isolate the causative agent. In this study, we correlated the parameters of severity of the disease with isolated bacteria.. Results: 225 germs were isolated from 180 patients. The infection was polymicrobial in 19 patients. The bacteria isolated were: SP:18 cases, HI:42 cases, Pseudomonas:37 cases and Acinetobacter:14 cases. Patients that experienced pyocyanic and/or Acinetobacter infections are more symptomatic than COPD patients with past history of exacerbations due to HI and/or SP (mMRC=2-4: 86% vs 71%, p=0,049), most often GOLD 3 and 4 (89% vs ...
Biohazard level, growth media and temperature, gram stain, industrial applications and more information for Acinetobacter bouvetii.
Las especies de Acinetobacter son, relativamente, microorganismos inofensivos con una gran capacidad de persistir en los ambientes hospitalarios por periodos prolongados como colonizantes y pudiendo ser una causa importante ...
Members of the genus Acinetobactercan frequently be isolated from healthy people and are also commonly present in soil and water as free-living saprophytes. In spite of an increasing number of...
TY - JOUR. T1 - Environmental exposure to carbapenem-resistant Acinetobacter baumannii as a risk factor for patient Acquisition of A. baumannii. AU - Rosa, Rossana. AU - Arheart, Kristopher L.. AU - Depascale, Dennise. AU - Cleary, Timothy. AU - Kett, Daniel H.. AU - Namias, Nicholas. AU - Pizano, Louis. AU - Fajardo-Aquino, Yovanit. AU - Silvia Munoz-Price, L.. PY - 2014. Y1 - 2014. N2 - We aimed to determine the association between environmental exposure to carbapenem-resistant Acinetobacter baumannii and the subsequent risk of acquiring this organism. Patients exposed to a contaminated hospital environment had 2.77 times the risk of acquiring carbapenem-resistant A. baumannii than did unexposed patients (relative risk, 2.77 [95% confidence interval, 1.50-5.13]; P p.002).. AB - We aimed to determine the association between environmental exposure to carbapenem-resistant Acinetobacter baumannii and the subsequent risk of acquiring this organism. Patients exposed to a contaminated hospital ...
Carbapenem resistance in Acinetobacter baumannii is a global problem. The purpose of this study was to elucidate current resistance mechanisms of imipenem-resistant A. baumannii (IRAB) in Taiwan and their correlation with patient outcomes. Acinetobacter baumannii clinical isolates from two teaching hospitals in Taiwan were collected in 2009 and were examined by Etest for determination of the minimum inhibitory concentrations (MICs) of imipenem, ceftazidime and ceftriaxone. Primers specific for carbapenemase genes and upstream regions were designed for PCR amplification. Bacterial isolates were genotyped by pulsed-field gel electrophoresis (PFGE). Clinical presentations of patients were analysed retrospectively. Upstream insertion sequence ISAba1 was found in 34 isolates that carried bla(OXA-23), including 28 with transposon Tn2006 (ISAba1-bla(OXA-23)-ISAba1) in an AbaR4-type resistance island and 6 with Tn2008 (ISAba1-bla(OXA-23)), as well as in 8 isolates carrying ISAba1-bla(OXA-51-like). All ...
Objectives. Multidrug-resistant Acinetobacter strain HK302 was isolated from an outbreak of nosocomial infections in Switzerland in 1977. The aim of the present study was to assess whether this archive strain belongs to one of the known international clonal lineages of Acinetobacter baumannii and whether it harbours a genomic structure related to the AbaR1-like resistance islands.. Methods. Multilocus sequence typing (MLST) and HindIII ribotyping were used to determine the taxonomic position of HK302 at the species and subspecies (clonal) levels. The position and structure of the putative resistance island were investigated by AbaR1-based PCR mapping followed by restriction analysis and partial sequencing of amplicons. A. baumannii AYE harbouring AbaR1 was used as a positive control for PCR mapping.. Results. The MLST allelic profile (1-1-1-1-5-1-1) and HindIII ribotype of HK302 were typical of A. baumannii European (EU) clone I. In addition, an AbaR1-related region inserted into the ATPase gene ...
OBJECTIVE: The aim of this multiple-hospital study was to investigate the prevalence of integrons in multidrug-resistant Acinetobacter baumannii (MDRAB) in Eastern China, and characterize the integron-integrase genes, so as to provide evidence for the management and appropriate antibiotic use of MDRAB infections.. METHODS: A total of 425 clinical isolates of A. baumannii were collected from 16 tertiary hospitals in 11 cities of four provinces (Fujian, Jiangsu, Zhejiang and Shandong) from January 2009 to June 2012. The susceptibility of A. baumannii isolates to ampicillin/sulbactam, piperacillin/tazobactam, ceftazidime, ceftriaxone, cefepime, aztreonam, meropenem, amikacin, gentamicin, tobramycin, ciprofloxacin, levofloxacin, sulfamethoxazole/trimenthoprim, minocycline and imipenem was tested, and integrons and their gene cassettes were characterized in these isolates using PCR assay. In addition, integron-positive A. baumannii isolates were genotyped using pulsed-field gel electrophoresis (PFGE) ...
Nosocomial pathogens can be associated with a variety of infections, particularly in intensive care units (ICUs) and in immunocompromised patients. Usually these pathogens are resistant to multiple drugs and pose therapeutic challenges. Among these organisms, Acinetobacter baumannii is one of the most frequent being encountered in the clinical setting. Carbapenems are very useful to treat infections caused by these drug-resistant Gram-negative bacilli, but carbapenem resistance is increasing globally. Combination therapy is frequently given empirically for hospital-acquired infections in critically ill patients and is usually composed of an adequate beta-lactam and an aminoglycoside. The purpose of this study was to evaluate the in vitro activity of plazomicin against carbapenem-resistant Acinetobacter baumannii. Amikacin was used as a comparator. The activity of plazomicin in combination with several different antibiotics was tested by disk diffusion, the checkerboard method, and time-kill ...
Carbapenem-resistant Acinetobacter baumannii is the top-ranked pathogen in the World Health Organization priority list of antibiotic-resistant bacteria. It emerged as a global pathogen due to the successful expansion of a few epidemic lineages, or international clones (ICs), producing acquired class D carbapenemases (OXA-type). During the past decade, however, reports regarding IC-I isolates in Latin America are scarce and are non-existent for IC-II and IC-III isolates. This study evaluates the molecular mechanisms of carbapenem resistance and the epidemiology of 80 non-duplicate clinical samples of A. baumannii collected from February 2014 through April 2016 at two tertiary care hospitals in Lima. Almost all isolates were carbapenem-resistant (97.5%), and susceptibility only remained high for colistin (95%). Pulsed-field gel electrophoresis showed two main clusters spread between both hospitals: cluster D containing 51 isolates (63.8%) associated with sequence type 2 (ST2) and carrying OXA-72, ...
Acinetobacter baumannii is a nosocomial pathogen which is establishing as a major cause of morbidity and mortality within the healthcare community. The success of this pathogen is largely due to its ability to rapidly gain resistance to antimicrobial therapies and its capability to persist in an abiotic environment through the production of a biofilm. Our tertiary-care hospital has showed high incidence of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. In this study we explore both genotypic and phenotypic properties of 26 CRAB isolates: 16 isolates were collected from January 2010 to March 2011, and 10 were collected between February and May 2015. We determined that all 26 CRAB isolates possessed multiple β-lactamase genes, including genes from Groups A, C, and D. Specifically, 42% of the isolates possesses the potentially plasmid-borne genes of OXA-23-like or OXA-40-like β-lactamase. The presence of mobile gene element integron cassettes and/or integrases
Acinetobacter baumannii has been increasingly reported in the outbreak of nosocomial infections in the intensive care units, which not only prolong the length of hospital stay but result in high attributable mortality. With its intrinsic resistance to many antimicrobial agents and rapid acquirement of resistance mechanism, resistance to carbapenems, which is often accompanied with resistance to multiple drugs, has emerged worldwide. The limited treatment choice included tigecycline, colistin, and sulbactam. However, the low serum level and bacteriostatic nature of tigecycline hamper its application in blood stream infection, one of the most common presentations of A. baumannii infections. The nephrotoxicity and neurotoxicity of intravenous colistin have caused great concerns in critically ill patients whereas immediate bronchospasm after inhalation and significant clinical consequences have been reported. Sulbactam has been used for decades in combination of ampicillin and well tolerated. ...
Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A blaVIM gene was detected in ~95 % of isolates; blaOXA-23 and blaOXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required.. ...
Objective To investigate the in vitro and in vivo antibacterial activities of tigecycline and other 13 common antimicrobial agents, alone or in combination, against multi-drug resistant Acinetobacter baumannii.MethodsAn in vitro susceptibility test of 101 Acinetobacter baumannii was used to detect minimal inhibitory concentrations (MICs). A mouse lung infection model of multi-drug resistant Acinetobacter baumannii,established by the ultrasonic atomization method, was used to define in vivo antimicrobial activities.Results Multi-drug resistant Acinetobacter baumannii showed high sensitivity to tigecycline (98% inhibition), polymyxin B (78.2% inhibition), and minocycline (74.2% inhibition). However, the use of these antimicrobial agents in combination with other antimicrobial agents produced synergistic or additive effects. In vivo data showed that white blood cell (WBC) counts in drug combination groups C (minocycline + amikacin) and D (minocycline + rifampicin) were significantly higher than in groups A
PubMedID: 24985124 | Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. | European journal of pediatrics | 7/2/2014
Carbapenem resistance in A. baumannii is most often associated with class D β-lactamases (OXA-23-like, OXA-40-like and OXA-58-like) and MBLs. OXA-type carbapenemases are predominant in A. baumannii, particularly in worldwide outbreaks of OXA-23 [24]. The molecular analysis of the isolates tested in this study revealed that 14 strains (51.8 %) carried the blaOXA-23-like gene and that two strains carried a blaOXA-24-like gene. All of the strains had a blaOXA-51-like gene, and four strains had a blaOXA-58 gene. In this study, the OXA-58 isolates presented lower MIC values for meropenem than OXA-23-like-positive isolates, which systematically exhibited higher MIC values (Table 1). The isolates with non-acquired OXA genes displayed a marked variation and included some carbapenem-resistant genes. Naturally occurring OXA carbapenemases, such as OXA-51-like enzymes (e.g., OXA 64-66, OXA 68-71, OXA 78-80, OXA-82, OXA-86, OXA-92 and OXA104-112), have been identified in A. baumannii isolates worldwide. In ...
Identifying Risk Factors for Healthcare-Associated Infections Caused by Carbapenem-Resistant Acinetobacter baumannii in a Neonatal Intensive Care Unit
The traditional markerless gene deletion technique based on overlap extension PCR has been used for generating gene deletions in multidrug-resistant Acinetobacter baumannii. However, the method is time-consuming because it requires restriction digestion of the PCR products in DNA cloning and the con …
In February 2006, a patient colonized with a multidrug-resistant sequence type 56 Acinetobacter baumannii strain was admitted to a hospital in Madrid, Spain. This strain spread rapidly and caused a large outbreak in the hospital. Clinicians should be ...
TY - JOUR. T1 - Variations in IS6 promoters alter the expression of carbapenem resistance in related strains of Acinetobacter baumannii. AU - Al-Hassan, Leena. AU - Opazo, Andres. AU - Lopes, Bruno S. AU - Mahallawy, Hadir El. AU - Amyes, Sebastian G B. N1 - The authors are thankful to the hospital staff at The Childrens Cancer Hospital and The National Cancer Institute (Cairo, Egypt) for providing the samples and allowing part of the work to be undertaken at their centres.. PY - 2015/3. Y1 - 2015/3. N2 - The aim of this work was to investigate the role of the IS6 family of insertion sequences present upstream of blaOXA-58 in two clonally related carbapenem-resistant Acinetobacter baumannii isolates obtained from paediatric cancer patients in Egypt. To determine their relatedness, the isolates were typed by pulsed-field gel electrophoresis (PFGE), and the intrinsic blaOXA-51-like gene was amplified and sequenced. Minimum inhibitory concentrations (MICs) to imipenem and meropenem was determined ...
TY - JOUR. T1 - Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan. AU - Liu, S. Y.. AU - Lin, J. Y.. AU - Chu, C.. AU - Su, L. H.. AU - Lin, T. Y.. AU - Chiu, C. H.. PY - 2006/1. Y1 - 2006/1. N2 - We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the blaIMP-1 gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no blaIMP, blaVIM or bla CFI genes, indicating that other uncharacterised metallo-β- lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of ...
Acinetobacter junii is a species of bacteria. Its type strain is ATCC 17908. It can be pathogenic. This bacterium has been linked to nosocomial infections including catheter-related blood stream infections and cellulitis. Vaneechoutte, M.; De Baere, T.; Nemec, A.; Musilek, M.; Van Der Reijden, T. J. K.; Dijkshoorn, L. (2008). Reclassification of Acinetobacter grimontii Carr et al. 2003 as a later synonym of Acinetobacter junii Bouvet and Grimont 1986. International Journal of Systematic and Evolutionary Microbiology. 58 (4): 937-940. doi:10.1099/ijs.0.65129-0. PMID 18398198. Bouvet, P. J. M.; Grimont, P. A. D. (1986). Taxonomy of the Genus Acinetobacter with the Recognition of Acinetobacter baumannii sp. nov., Acinetobacter haemolyticus sp. nov., Acinetobacter johnsonii sp. nov., and Acinetobacter junii sp. nov. and Emended Descriptions of Acinetobacter calcoaceticus and Acinetobacter lwoffii. International Journal of Systematic Bacteriology. 36 (2): 228-240. doi:10.1099/00207713-36-2-228. ...
Objectives: In this study we retrospectively reviewed A. baumannii meningitis cases treated with tigecycline including regimens and evaluated the efficacy of tigecycline in the therapy. ...
Acinetobacter baumannii bacteremia is becoming more prevalent and is associated with increasing morbidity and mortality. Escalating antibacterial resistance further contributes to therapeutic dilemmas, enhanced infection control support and poorer outcomes in patients infected with these bacteria. A retrospective analysis of patients whose blood cultures produced A. baumannii from January 2007 through January 2013 was performed. Data regarding the epidemiologic features, antimicrobial susceptibility and outcomes of patients with A. baumannii bacteremia were collected and analyzed. Sixty A. baumannii isolates each from a different patient were identified. The Charlson Comorbidity Index (≥3) was the greatest among patients with multi-drug resistance (MDR) compared to intermediate drug resistance (IDR) and pan-sensitive (PS) A. baumannii. The mean APACHE II scores for MDR, IDR and PS A. baumannii bacteremia were 21, 15 and 11, respectively (P < 0.05, MDR v. PS). Seventy-three percent of the isolates were
Patients with AB bacteremia receiving antimicrobial therapy are eligible for this multicenter study. Antimicrobial agents are decided at the discretion of the attending clinical team. Clinical data to be collected include patient demographics (age, gender, underlying diseases, Pitt Bacteremia Score [20], duration of ICU stay and hospitalization before the day of first positive blood culture, central venous catheterization), antimicrobial agents on the day of bacteremia, regimens and durations of combination therapy after enrollment, and outcomes (sequential quantification change of blood A. baumannii polymerase chain reaction [PCR], survival at day 30 after enrollment, and adverse drug reactions of antimicrobial agents). Blood sample will be collected on the day of enrollment (Day 0), Day 1, 2, 3 and 7 for PCR quantification of A. baumannii and for genospecies identification. Primary end points are the interval from study enrollment to negative blood A. baumannii PCR and blood sterilization. ...
Bacteria of the genus Acinetobacter are ubiquitous in nature. These organisms were invariably susceptible to many antibiotics in the 1970s. Since that time, acinetobacters; have emerged as multiresistant opportunistic nosocomial pathogens. The taxonomy of the genus Acinetobacter underwent extensive revision in the mid-1980s, and at least 32 named and unnamed species have now been described. Of these, Acinetobacter baumannii and the closely related unnamed genomic species 3 and 13 sensu Tjernberg and Ursing (13TU) are the most relevant clinically. Multiresistant strains of these species causing bacteraemia, pneumonia, meningitis, urinary tract infections and surgical wound infections have been isolated from hospitalised patients worldwide. This review provides an overview of the antimicrobial susceptibilities of Acinetobacter spp. in Europe, as well as the main mechanisms of antimicrobial resistance, and summarises the remaining treatment options for multiresistant Acinetobacter infections. © ...
Rates of A. baumannii bacteraemia significantly increased between 2005 and 2009, from 0.1 to 3.2 cases/100,000 inhabitants per year. The observed increase was due to carbapenem-resistant isolates, while the number of carbapenem-susceptible isolates remained substantially stable over the study period. Importantly, the occurrence of carbapenem-resistant isolates showed a steep five-fold increase between 2008 and 2009. These isolates belonged to an epidemic strain detected in several departments of 4 hospital trusts in the Region. Similar trends were observed for urine and respiratory isolates. The total number of isolates in blood, urine and respiratory specimens, including both colonizing and infecting strains, increased from 51 in 2005 to 826 in 2009, with rates rising from 1.5 to 19.0 isolates/100,000 inhabitants per year. ...
As part of the SENTRY Antimicrobial Surveillance Program, a total of 1078 Acinetobacter species and 842 Stenotrophomonas maltophilia isolates were collected between January 1997 and December 1999 from 5 geographic regions (Canada, the United States, Latin America, Europe, and the Asia-Pacific). The frequency of infections (by geographic region and body site), including those due to imipenem-resistant Acinetobacter species and trimethoprim-sulfamethoxazole (TMP-SMZ)-resistant S. maltophilia, was evaluated. The possibility of seasonal variations in bloodstream infections caused by Acinetobacter species was studied, as was the activity of several therapeutic antimicrobials against all strains. Acinetobacter species and S. maltophilia were most frequently associated with pulmonary infections, independent of the region evaluated. In contrast, patterns of antimicrobial resistance markedly varied among distinct geographic regions, especially for nosocomial isolates. Although the carbapenems were the ...
This unit describes basic protocols for infecting mice through intranasal and intraperitoneal routes with Acinetobacter baumannii to induce associated pneumonia and sepsis, the two most common manifestations of clinical infections with this pathogen
Management of multidrug-resistant organisms in healthcare settings, 2006. 2007. Kluytmans-Vandenbergh, MF, Kluytmans, JA, Voss, A. Dutch guideline for preventing nosocomial transmission of highly resistant microorganisms (HRMO). Infection. vol. 33. 2005. pp. 309-13. Peleg, AY, Seifert, H, Paterson, DL. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev. vol. 21. 2008. pp. 538-82. Dijkshoorn, L, Nemec, A, Seifert, H. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol. vol. 5. 2007. pp. 939-51. Nemec, A, Krízová, L, Maixnerová, M, Diancourt, L, van der Reijden, TJ, Brisse, S, van den Broek, P, Dijkshoorn, L. Emergence of carbapenem resistance in Acinetobacter baumannii in the Czech Republic is associated with the spread of multidrug-resistant strains of European clone II. J Antimicrob Chemother. vol. 62. 2008. pp. 484-9. Higgins, PG, Dammhayn, C, Hackel, M, Seifert, H. Global spread of carbapenem-resistant ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for MDR, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigated 118 patients, on 27 wards, in whom MDR A. baumannii was isolated from clinical cultures. Each case-patient had a control without MDR A. baumannii and was matched for hospital length of stay, ward, and calendar time. The epidemiologic investigation found small clusters of up to 6 patients each with no common identified source. Ten different PFGE clones were found, of which 2 dominated. The PFGE pattern differed within temporospatial clusters, and antimicrobial drug susceptibility patterns varied within and between clones. Multivariate analysis identified the following significant risk factors: male sex, cardiovascular disease, having undergone mechanical ventilation, and having been treated with
In recent years, the number of nosocomial infections caused byAcinetobacter baumannii has increased significantly (4). Many outbreaks have been reported, especially among patients confined to hospital intensive care units, where the widespread use of antibiotics may select multidrug-resistant strains. The difficulty of treating A. baumannii nosocomial infection is associated with the high resistance to a wide range of antimicrobial agents frequently observed in this species (8). Often, imipenem remains one of the few therapeutic alternatives. Fortunately, imipenem resistance is relatively rare among Acinetobacter clinical isolates. Carbapenem resistance can arise by a decrease in expression of an outer membrane protein (3) or by alteration in penicillin-binding proteins (5). In general, the emergence of carbapenem-hydrolyzing enzymes has been limited compared to the prevalence of other β-lactamases (1). However, in 1985 in Scotland, anA. baumannii strain that produced a plasmid-mediated ...
Multi-drug resistant Acinetobacter baumannii bacteria inside biofilm, computer illustration. A. baumannii is a Gram-negative, oxidase negative, aerobic, coccobacillus. It has always been naturally resistant to multiple antibiotics. It can be especially resistant to penicillin and chloramphenicol. It causes various nosocomial infections, including, skin and wound infections, pneumonia, meningitis, septicaemia, urinary tract infection and endocarditis. It is commonly found in soil, water, sewage, and normal skin and gastrointestinal tract flora. It is the most frequently encountered species in the clinical laboratory. Species found in soil can colonize root nodule systems and oxidize the hydrogen produced by nitrogen fixing bacteria. The illustration shows morphology of Acinetobacter such as short rods and sometimes long filamentous cells. - Stock Image F018/1264
Molecular characterization and antimicrobial susceptibility of Acinetobacter baumannii isolates obtained from two hospital outbreaks in Los Angeles County, California, USA
Acinetobacter baumannii is currently one of the key nosocomial pathogens causing severe infections; of special concern is its resistance to expanded-spectrum cephalosporins (ESCs) and carbapenems, often associated with the few so-called European clones (6, 7, 19). It has two natural -lactamases, an AmpC-like enzyme (Acinetobacter-derived cephalosporinase [ADC]) (10) and a carbapenem-hydrolyzing class D -lactamase (CHDL; the OXA-51 type) (15), which affect susceptibility upon increased expression due to ISAba1 insertion upstream of their genes (9, 18). Moreover, acquired -lactamases, including metallo-lactamases (MBLs) and four CHDL types, the OXA-23, OXA-24/40, OXA-58, and OXA-143 types, are observed (15). Knowledge of A. baumannii in Poland has been limited to single isolates (9, 14, 21); our aim was to analyze a bigger group of A. baumannii strains. (Part of this work was presented at the 22nd European Congress of Clinical Microbiology and Infectious Diseases, London, United Kingdom, 31 March to 3
Acinetobacter (/ˌæsɪˈniːtoʊbæktər/) is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria. Acinetobacter species are oxidase-negative, exhibit twitching motility, and occur in pairs under magnification. They are important soil organisms, where they contribute to the mineralization of, for example, aromatic compounds. Acinetobacter species are a key source of infection in debilitated patients in the hospital, in particular the species Acinetobacter baumannii. Species of the genus Acinetobacter are strictly aerobic, nonfermentative, Gram-negative bacilli. They show mostly a coccobacillary morphology on nonselective agar. Rods predominate in fluid media, especially during early growth. The morphology of Acinetobacter species can be quite variable in Gram-stained human clinical specimens, and cannot be used to differentiate Acinetobacter from other common causes of infection. Most strains of Acinetobacter, except some of the A. lwoffii strain, grow well on ...
Acinetobacter baumannii causes severe nosocomial infections such as pneumonia, meningitis and sepsis with high mortality rates. This organism represents an increasing danger for immunocompromised adults, especially since there are an increasing number of resistances against antibiotics. Until now, scientific investigation was mainly focused on taxonomy and antibiotic resistance mechanisms. The goal of this project was to analyse the interaction between clinical strains of Acinetobacter baumannii and human cells in order to address the molecular mechanisms causing pathogenicity. Adherence is the first step in colonization of human tissue, and therefore a key event in pathogenesis. To demonstrate the adhesion of bacteria to human cells, a colony counting assay has been established. These experiments used the the type strain of A. baumannii ATCC 19606, as well as clinical isolates. All A. baumannii strains investigated showed adhesion to the lung epithelial cells A549, but the adhesion capacity was ...
Acinetobacter baumannii ATCC ® 19606D-5™ Designation: Genomic DNA from Acinetobacter baumannii strain 2208 TypeStrain=True Application: Food testing
Acinetobacter baumannii ATCC ® 17978D-5™ Designation: Genomic DNA from Acinetobacter baumannii Strain 5377 TypeStrain=False Application:
A. baumannii is commonly involved in nosocomial infections, but few therapeutic options are available. Find out what there is to know.
Construction of Integrated Analytic Platform for Acinetobacter Baumannii in Taiwan-Network Analysis and Comparative Genomics Study on Acinetobacter Baumannii Isolates from Taiwan(2/3 ...
Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting [email protected] All previous versions of the manuscript and all author responses to the reviewers are also available.. You can find further information about the peer review system here.. ...
TY - JOUR. T1 - Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections. AU - Ostorhazi, Eszter. AU - Rozgonyi, Ferenc. AU - Sztodola, Andras. AU - Harmos, Ferenc. AU - Kovalszky, Ilona. AU - Szabo, Dora. AU - Knappe, Daniel. AU - Hoffmann, Ralf. AU - Cassone, Marco. AU - Wade, John D.. AU - Bonomo, Robert A.. AU - Otvos, Laszlo. PY - 2010/9/1. Y1 - 2010/9/1. N2 - Objectives: The designer antibacterial peptide A3-APO is efficacious in mouse models of Escherichia coli and Acinetobacter baumannii systemic infections. Here we compare the efficacy of the peptide with that of imipenem and colistin in A. baumannii wound infections after burn injury. Methods: CD-1 mice were inflicted with burn wounds and different inocula of A. baumannii, isolated from an injured soldier, were placed into the wound sites. The antibiotics were given intramuscularly (im) one to five times. Available free peptide in the blood and the ...
The highly variable nature of the internal transcribed spacer region (ITS) has been claimed to represent an ideal target for designing species-specific probes/primers capable of differentiating between closely related Acinetobacter species. However, several Acinetobacter species contain multiple ITS copies of variable lengths, and these include Acinetobacter bereziniae, Acinetobacter guillouiae and Acinetobacter baylyi. This study shows these length variations result from inter-genomic insertion/deletion events (indels) involving horizontal transfer of ITS fragments of other Acinetobacter species and possibly unrelated bacteria, as shown previously by us. In some instances, indel incorporation results in the loss of probe target sites in the recipient cell ITS. In other cases, some indel sequences contain target sites for probes designed from a single ITS sequence to target other Acinetobacter species. Hence, these can generate false positives. The largest of the indels that remove probe sites is 683 bp
INTRODUCTION: The incidence of multidrug resistant microorganisms worldwide is increasing. The aim of the study was to present institutional experience with the multidrug resistant microorganism colonization patterns observed in children with congenital heart diseases hospitalized in a hybrid pediatric cardiac surgery center. MATERIAL AND METHODS: Microbiological samples were routinely collected in all children admitted to our department. All microbiological samples were analyzed with regard to multidrug resistant microorganisms: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Gram-negative rods producing extended-spectrum beta-lactamases (ESBL), multidrug resistant Gram-negative rods (MDR-GNRs), carbapenemase-producing Klebsiella pneumoniae (KPC), carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA ...
Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity.: Acinetobacter baumannii is an emerging opportunistic pathogen re
Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ... Human papillomavirus (HPV) infection One of the Human papillomaviruses Human parainfluenza virus infection Human parainfluenza ... Infections associated with diseases. References[edit]. *^ Walsh TJ, Dixon DM (1996). Baron S, et al., eds. Spectrum of Mycoses ... Haemophilus influenzae infection Haemophilus influenzae Hand, foot and mouth disease (HFMD) Enteroviruses, mainly Coxsackie A ...
Use of colistin to treat Acinetobacter baumannii infections has led to the development of resistant bacterial strains. which ... Towner K J (2008). "Molecular Basis of Antibiotic Resistance in Acinetobacter spp.". Acinetobacter Molecular Biology. Caister ... and it has come into recent use for treating multidrug-resistant Acinetobacter infection, although resistant forms have been ... "Colistin and rifampicin in the treatment of nosocomial infections from multiresistant Acinetobacter baumannii". Journal of ...
Infections caused by the non-fermenting gram-negative bacteria Pseudomonas aeruginosa and Acinetobacter baumanni are most ... Rice LB (2006). "Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter ... and meropenem are recommended for high-risk community-acquired abdominal infections and for abdominal infections that are ... "Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection ...
"PheWAS uncovers a pathological role of coagulation Factor X during Acinetobacter baumannii infection". Infection and Immunity. ... Polymorphisms in Factor X have been associated with an increased prevalence in bacterial infections, suggesting a possible role ...
Iregbu, K. C.; Ogunsola, F. T.; Odugbemi, T. O. (2002). "Infections caused by Acinetobacter species and their susceptibility to ... She was a founding member of the Nigerian Society for Infection control in 1998 and is also a member of the Global Infection ... 1996 Infections caused by Acinetobacter species and their susceptibility to 14 antibiotics in Lagos University Teaching ... She has also been the chairman of Infection Control Committee of Lagos University Teaching Hospital. Additionally, she is the ...
Acinetobacter is a gram-negative bacteria that causes pneumonia or bloodstream infections in critically ill patients. Multidrug ... Infections are most frequent in people who have had recent medical and/or antibiotic treatment. C. difficile infections ... Associated with these infections were an estimated 15,000 deaths. The CDC estimates that C. difficile infection costs could ... Centers for Disease Control Prevention (CDC). (2004). "Acinetobacter baumannii infections among patients at military medical ...
Risk factors for infection with an MDR strain include ventilation for more than five days, recent hospitalization (last 90 days ... It is often resistant to a wide array of antibiotics but is usually sensitive to co-trimoxazole Acinetobacter are becoming more ... Even in cases with positive blood cultures, the bacteremia may be from a source other than the lung infection. Prevention of ... Ventilator-associated pneumonia (VAP) is a type of lung infection that occurs in people who are on mechanical ventilation ...
He is known for his research on healthcare related infections with special emphasis on Acinetobacter, Klebsiella, ESKAPE, Human ... Srinivasan VB, Vaidyanathan V, Rajamohan G. AbuO, a TolC-like outer membrane protein of Acinetobacter baumannii, is involved in ... an RND-Type Membrane Transporter in Antimicrobial Resistance in Acinetobacter baumannii. PLoS One. 2015 Oct 23;10(10):e0141314 ...
Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection". ... Infection prevention is the most efficient strategy of prevention of an infection with a MDR organism within a hospital, ... Use the appropriate antimicrobial for an infection; e.g. no antibiotics for viral infections Identify the causative organism ... Lomentospora prolificans infections are often fatal because of their resistance to multiple antifungal agents. HIV is the prime ...
... -Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection". ... For instance, infection of Pseudomonas aeruginosa by the temperate phage PaP3 changed the expression of 38% (2160/5633) of its ... Mice treated with the phage cocktail showed a 2.3-fold higher survival rate than those untreated in seven days post infection. ... Therapeutic efficacy of a phage cocktail was evaluated in a mice model with nasal infection of multidrug-resistant (MDR) A. ...
... critically ill with a completely antibiotic-resistant Acinetobacter baumannii infection following severe pancreatitis. Viruses ... In 2019, a Brownsville, MN man with a long-standing bacterial infection in his knee received a phage treatment at the Mayo ... IV phage drip therapy was successfully used to treat a patient with MDR Acinetobacter baumannii in Thornton Hospital at UC San ... "Bacteriophage: A solution to our antibiotics problem? How we can us a virus to fight bacterial infection". Science in the News ...
Patterson had a systemic Acinetobacter baumannii infection that manifested while he was on vacation with his wife, Dr. ... The center currently treats patients with life-threatening multi-drug resistant infections with phage therapy, on a case-by- ... IPATH aims to initiate phase I/II phage therapy clinical trials, focusing on patients with cystic fibrosis and infections ... Phage therapy is the method by which bacteriophages (viruses which infect bacteria) are used to treat bacterial infections or ...
... associated with hospital-acquired infections include Acinetobacter baumannii, which cause bacteremia, ... It has also been studied in gram-negative species found in soil such as Pseudomonas stutzeri, Acinetobacter baylyi, and gram- ... This is why some infections with gram-negative bacteria can lead to life-threatening septic shock. The outer membrane protects ... Drugs commonly used to treat gram negative infections include amino, carboxy and ureido penicillins (ampicillin, amoxicillin, ...
"Acinetobacter baumannii infections among patients at military medical facilities treating injured U.S. service members, 2002- ... Acinetobacter resistente a multidrogas[editar , editar a fonte]. Acinetobacter é unha baceria gramnegativa que causa pneumonía ... "Medscape abstract on Acinetobacter baumannii: Acinetobacter baumannii: An Emerging Multidrug-resistant Threat". membership only ... Acinetobacter baumannii[editar , editar a fonte]. En 2004, os Centros para o Control de Enfermidades e Prevención (CDC) de EUA ...
... airborne acinetobacter infections in a ward were eliminated by the installation of a negative air ioniser-the infection rate ... The frequency of nosocomial infections in British hospitals prompted the National Health Service (NHS) to research the ... McDowell, Natasha (3 January 2003). "Air ionisers wipe out hospital infections". The New Scientist (Daily news). Retrieved 24 ...
... research into pathogens infecting combat wounds resulting in the first descriptions of acinetobacter baumannii infection in ... reflecting its focus on tropical infections of interest to the military such as malaria and Dengue fever. In 1947 NAMRU-2 ...
... complicated intra-abdominal infections, complicated urinary tract infections, and nosocomial respiratory tract infections. ... Acinetobacter, and Enterobacter. In addition, some Mycobacteria, including the bacteria that cause tuberculosis, are ... Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more ... In the past, the aminoglycosides have been used in conjunction with beta-lactam antibiotics in streptococcal infections for ...
... and cannot be used to differentiate Acinetobacter from other common causes of infection. Most strains of Acinetobacter, except ... Acinetobacter species are a key source of infection in debilitated patients in the hospital, in particular the species ... Acinetobacter is frequently isolated in nosocomial infections, and is especially prevalent in intensive care units, where both ... Visca P, Seifert H, Towner KJ (December 2011). "Acinetobacter infection--an emerging threat to human health". IUBMB Life. 63 ( ...
Pseudomonas and Acinetobacter species". Clinical Microbiology and Infection. 20 (9): 831-8. doi:10.1111/1469-0691.12655. PMID ... Antibiotic treatment duration should be based on the infection and other health problems a person may have. For many infections ... reduce the incidence of infection through effective sanitation, hygiene and infection prevention measures. optimize the use of ... Clinical investigation to rule out bacterial infections are often done for patients with pediatric acute respiratory infections ...
They can cause infection in debilitated patients. LPSN lpsn.dsmz.de Straininfo of Acinetobacter pittii Taxonomy Browser Nemec, ... formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Acinetobacter genomic species 13TU ... "Acinetobacter pittii and Acinetobacter nosocomialis among clinical isolates of the Acinetobacter calcoaceticus-baumannii ... characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii ...
... can cause bloodstream infection in neonates. LPSN lpsn.dsmz.de Straininfo of Acinetobacter soli Dongyou Liu ... "Acinetobacter soli as a Cause of Bloodstream Infection in a Neonatal Intensive Care Unit". Journal of Clinical Microbiology. 49 ... Kim, D.; Baik, K. S.; Kim, M. S.; Park, S. C.; Kim, S. S.; Rhee, M. S.; Kwak, Y. S.; Seong, C. N. (2008). "Acinetobacter soli ... Acinetobacter soli is a Gram-negative, catalase-positive, oxidase-negative, strictly aerobic rod-shaped, nonmotile bacterium ...
Rathinavelu, S; Zavros, Y; Merchant, JL (June 2003). "Acinetobacter lwoffii infection and gastritis". Microbes and Infection / ... It can cause infections in human hosts, particularly catheter-associated infections in immunocompromised patients. It has also ... Acinetobacter lwoffii, formerly known as Mima polymorpha or Acinetobacter calcoaceticus var. lwoffii, is a non-fermentative ... Type strain of Acinetobacter lwoffii at BacDive - the Bacterial Diversity Metadatabase v t e. ...
"Blood stream infections caused by Acinetobacter ursingii in an obstetrics ward". Infection, Genetics and Evolution. 11 (1): 52- ... "Acinetobacter ursingii sp. nov. and Acinetobacter schindleri sp. nov., isolated from human clinical specimens". International ... and antimicrobial susceptibilities of Acinetobacter ursingii and Acinetobacter schindleri, two frequently misidentified ... Acinetobacter ursingii is a species of potentially pathogenic bacteria. Its type strain is LUH 3792T (= NIPH 137T = LMG 19575T ...
2012). "Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: Association with ... Aivazova, V; Kainer, F; Friese, K; Mylonas, I (January 2010). "Acinetobacter baumannii infection during pregnancy and ... Acinetobacter can be spread by person-to-person contact or contact with contaminated surfaces. Acinetobacter can enter through ... Parte, A.C. "Acinetobacter". LPSN. Lin, Ming-Feng; Lan, Chung-Yu (2014). "Antimicrobial Resistance in Acinetobacter baumannii: ...
"Clinical characteristics of patients with Acinetobacter junii infection". Journal of Microbiology, Immunology, and Infection = ... nov., Acinetobacter haemolyticus sp. nov., Acinetobacter johnsonii sp. nov., and Acinetobacter junii sp. nov. and Emended ... "Acinetobacter junii" at the Encyclopedia of Life Type strain of Acinetobacter junii at BacDive - the Bacterial Diversity ... Bouvet, P. J. M.; Grimont, P. A. D. (1986). "Taxonomy of the Genus Acinetobacter with the Recognition of Acinetobacter ...
... is a bacterium from the genus of Acinetobacter which has been isolated from human infections. ... Parte, A. C. "Acinetobacter". LPSN. Nemec, A.; Radolfova-Krizova, L.; Maixnerova, M.; Sedo, O. (July 2017). "Acinetobacter ... Type strain of Acinetobacter colistiniresistens at BacDive - the Bacterial Diversity Metadatabase v t e. ... isolated from human infections and characterized by intrinsic resistance to polymyxins". International Journal of Systematic ...
... aureus infection and a disease caused by drug-resistant Acinetobacter spp. A list of uses includes: Amoebic dysentery Anthrax ... Urinary tract infections, rectal infections, and infections of the cervix caused by certain microbes Both minocycline and ... Minocycline is also used for other skin infections such as methicillin-resistant Staphylococcus aureus as well as Lyme disease ... Rogers RL, Perkins J (September 2006). "Skin and soft tissue infections". Prim. Care. 33 (3): 697-710. doi:10.1016/j.pop. ...
... therapy after he acquired a life-threatening infection with a 'superbug', Acinetobacter baumannii. Although phage therapy had ... Her early research in Vancouver, Canada identified a major outbreak of HIV infection that occurred among injection drug users ... As a result of the Patterson case, dozens other patients with multidrug resistant bacterial infections have been treated with ... 1] JAMA and Lancet [2] [3],[4] [5][6] UC San Diego Health (2018-06-21), Turning a Phage: Innovative Therapy Clears Infection ...
April 2007). "Control of an outbreak of pandrug-resistant Acinetobacter baumannii colonization and infection in a neonatal ... In the US, the most frequent type of infection hospital is urinary tract infection (36%), followed by surgical site infection ( ... In 2006, the most common infection sites were urinary tract infections (30,3%), pneumopathy (14,7%), infections of surgery site ... 14,2%). Infections of the skin and mucous membrane (10,2%), other respiratory infections (6,8%) and bacterial infections / ...
"Repeated airborne infections of the multi-resistant bacteria acinetobacter in an intensive care ward have been eliminated by ... Adjacent un-ionised wards continued to experience infections" The results were encouraging and an article in New Scientist ... "Air ionisers wipe out hospital infections - 03 January 2003". New Scientist. 3 January 2003. Retrieved 23 February 2014. "For ...
Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection.[12] ... A urinary tract infection (UTI) is an infection that affects part of the urinary tract.[1] When it affects the lower urinary ... Urinary tract infections are the most frequent bacterial infection in women.[17] They occur most frequently between the ages of ... Lower urinary tract infection is also referred to as a bladder infection. The most common symptoms are burning with urination ...
... inflammation and bacterial infection in the respiratory tract. Lactoferrin with hypothiocyanite has been granted orphan drug ... Acinetobacter species • Aeromonas hydrophila • Bacillus brevis • Bacillus Cereus • Bacillus megaterium • Bacillus subtilis • ... "Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice". J. Med. Microbiol ... weakened respiratory immune system against bacterial infection. Symptoms of cystic fibrosis include an inability to secrete ...
... of people with gonorrheal infection also have chlamydial infection.[54] Infections of the throat can be especially problematic ... Both men and women with infections of the throat may experience a sore throat, though such infection does not produce symptoms ... The infection is usually spread from one person to another through vaginal, oral, or anal sex.[15][22] Men have a 20% risk of ... "Gonococcal Infections - 2015 STD Treatment Guidelines". 4 January 2018.. *^ Ryan, KJ; Ray, CG, eds. (2004). Sherris Medical ...
... is an infection of the small intestine by some strains of the bacterium Vibrio cholerae.[4][3] Symptoms may range from ... "The Journal of Infection. 66 (5): 432-8. doi:10.1016/j.jinf.2012.11.013. PMC 3677557. PMID 23201968.. ... Infection with V. cholerae O139 should be reported and handled in the same manner as that caused by V. cholerae O1. The ... Cholera - Vibrio cholerae infection-Centers for Disease Control and Prevention. *‹See Tfd›. "Cholera" . Encyclopædia Britannica ...
If the infection is severe, the doctor may prescribe antibiotics, such as ciprofloxacin or TMP-SMX (Bactrim). Unfortunately, ... In addition, chronic arthritis secondary to S. flexneri infection, called reactive arthritis, may be caused by a bacterial ... Bacillary dysentery should not be confused with diarrhea caused by other bacterial infections. One characteristic of bacillary ... human enteric infections". Vaccine. 24 (15): 2732-50. doi:10.1016/j.vaccine.2005.10.014. PMID 16483695.. ...
... such as a necrotizing soft tissue infection, an infection causing inflammation of the abdominal cavity lining, an infection of ... Acinetobacter baumannii, addition of antibiotic specific to gram-negative organism is recommended. For Methicillin-resistant ... Sepsis is an inflammatory immune response triggered by an infection.[3][4] Bacterial infections are the most common cause, but ... For Legionella infection, addition of macrolide or fluoroquinolone is chosen. If fungal infection is suspected, an echinocandin ...
Pseudomonas aeruginosa (Pseudomonas infection) · Moraxella catarrhalis · Acinetobacter baumannii. Xanthomonadales. ...
... (TD) is a stomach and intestinal infection. TD is defined as the passage of unformed stool (one or more by ... The primary source of infection is ingestion of fecally contaminated food or water. Attack rates are similar for men and women. ... Antibiotics can also cause vaginal yeast infections, or overgrowth of the bacterium Clostridium difficile, leading to ... Since wilderness campsites seldom provide access to sanitation facilities, the infection risk is similar to that of any ...
... since it is the second-most common infection in hospitalized patients (nosocomial infections)[citation needed]. This ... and Intergeneric Similarities of the Ribosomal Ribonucleic Acid Cistrons of Acinetobacter". International Journal of Systematic ... Main article: Pseudomonas infection. Infectious species include P. aeruginosa, P. oryzihabitans, and P. plecoglossicida. P. ... Lau GW; Hassett DJ; Ran H; Kong F (2004). "The role of pyocyanin in Pseudomonas aeruginosa infection". Trends in Molecular ...
Salih, Barik (June 2007). "H pylori infection and other risk factors associated with peptic ulcers in Turkish patients: A ... 2002). "Long-term stress and Helicobacter pylori infection independently induce gastric mucosal lesions in C57BL/6 mice". Scand ... "Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice". J. Antimicrob. Chemother. 51 (2): 367-71 ...
Infections à méningocoques Maladies infectieuses et Africa. West Africa. Med. Bull. 2007[unreliable source?] ... Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed meningococcus). It has a ... Meningococcal infection is usually introduced into a household by an asymptomatic person. Carriage then spreads through the ... meningitidis infection than complement-satisfactory persons,[27][28][29][30][31][32][33] and it was estimated that the risk of ...
This infection-related cutaneous condition article is a stub. You can help Wikipedia by expanding it.. *v ... Chromobacteriosis infections are a cutaneous condition caused by chromobacteria characterized by fluctuating abscesses.[1]:279 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Chromobacteriosis_infection&oldid=910443079" ...
16.0 16.1 16.2 16.3 16.4 Simon HB (2005).Infectious Disease:XX:Pneumonia and Other Pulmonary Infections.in David C. Dale, ... Kwa AL,et al.Nebulized colistin in the treatment of pneumonia due to multidrug-resistant Acinetobacter baumannii and ... 48.0 48.1 48.2 48.3 48.4 48.5 Tablan OC, Anderson LJ, Besser R, Bridges C, Hajjeh R, Health care Infection Control Practices ... Greenwood, David (1997). Medical Microbiology: A Guide to Microbial Infections: Pathogenesis, Immunity, Laboratory Diagnosis ...
Though usually not pathogenic, it can cause skin infections and even life-threatening illnesses in those that are ... Acinetobacter johnsonii Frequent occasionally pathogenic Pseudomonas aeruginosa Infrequent occasionally pathogenic Fungal[edit] ... if it gains entry into the circulatory system it can result in infections in bone, joint, gastrointestinal, and respiratory ... This works against staphylococcal and streptococcal infections. Pseudomonas aeruginosa also produces substances that inhibit ...
... such as necrotizing soft tissue infection, infection causing inflammation of the abdominal cavity lining, infection of the bile ... Acinetobacter baumannii, addition of antibiotic specific to gram-negative organism is recommended. For Methicillin-resistant ... For Legionella infection, addition of macrolide or fluoroquinolone is chosen. If fungal infection is suspected, an echinocandin ... the most common cause of fungal sepsis is infection by Candida species of yeast,[21] a frequent hospital-acquired infection. ...
Pseudomonas infection. *Moraxella catarrhalis. *Acinetobacter baumannii. Xanthomonadaceae. *Stenotrophomonas maltophilia. ...
Confirmation of infection can be done by examining serum taken during the early and late stages of infection. To quickly screen ... The three types of plague are the result of the route of infection: bubonic plague, septicemic plague, and pneumonic plague.[1] ... 14] With no new rat inputs being added to the population from other areas, the infection would only spread to humans in very ... Bubonic plague is an infection of the lymphatic system, usually resulting from the bite of an infected flea, Xenopsylla cheopis ...
... of infection together with systemic manifestations of infection".[4] These manifestations may include:. *Tachypnea (fast rate ... Acinetobacter baumannii, and Pseudomonas aeruginosa". Frontiers in Immunology. 6: 595. doi:10.3389/fimmu.2015.00595. PMID ... The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites. It may be located in ... Documented evidence of infection, may include positive blood culture, signs of pneumonia on chest x-ray, or other radiologic or ...
u žurnalu „Klinička mikrobiologija i infekcije" (engl. Clinical Microbiology and Infection)[2] ... Acinetobacter baumanii, Pseudomonas aeruginosa)[3] ...
... such as necrotizing soft tissue infection, infection causing inflammation of the abdominal cavity lining, infection of the bile ... Acinetobacter baumannii, addition of antibiotic specific to gram-negative organism is recommended. For Methicillin-resistant ... Sepsis is caused by an inflammatory immune response triggered by an infection.[2][3] Most commonly, the infection is bacterial ... For Legionella infection, addition of macrolide or fluoroquinolone is chosen. If fungal infection is suspected, an echinocandin ...
... complicated intra-abdominal infections, complicated urinary tract infections, and nosocomial respiratory tract infections. ... Acinetobacter, and Enterobacter. In addition, some Mycobacteria, including the bacteria that cause tuberculosis, are ... Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, ... As noted, aminoglycosides are mostly ineffective against anaerobic bacteria, fungi, and viruses.[2] Infections caused by Gram- ...
Pseudomonas aeruginosa (Pseudomonas infection) · Moraxella catarrhalis · Acinetobacter baumannii. Xanthomonadales. ...
emulsan (Acinetobacter calcoaceticus). *galactoglucopolysaccharides (Achromobacter spp., Agrobacterium radiobacter, Pseudomonas ... It also allows for successful invasion and infection of the host plant.[11] ...
Trematode infection). Blood fluke. *Schistosoma mansoni / S. japonicum / S. mekongi / S. haematobium / S. intercalatum * ... Tapeworm - Tapeworm infection Cestoda, Taenia multiceps intestine stool rare worldwide Diphyllobothriasis - tapeworm ... Dioctophyme renalis infection Dioctophyme renale kidneys (typically the right) urine rare ingestion of undercooked or raw ... sexually transmitted infection - only trophozoite form (no cysts) Sleeping sickness Trypanosoma brucei brain and blood ...
K. aerogenes is a nosocomial and pathogenic bacterium that causes opportunistic infections including most types of infections. ... Some of the infections caused by K. aerogenes result from specific antibiotic treatments, venous catheter insertions, and/or ...
IgM shows recent infection whereas IgG signifies remote infection. The most important limitation of this test is that it is not ... Typhoid fever, also known simply as typhoid, is a bacterial infection due to Salmonella typhi that causes symptoms.[3] Symptoms ... The typhidot test becomes positive within 2-3 days of infection and separately identifies IgM and IgG antibodies. The test is ... Cholecystectomy is not always successful in eradicating the carrier state because of persisting hepatic infection. ...
... associated with hospital-acquired infections include Acinetobacter baumannii, which cause bacteremia, ... Drugs commonly used to treat gram negative infections include amino, carboxy and ureido penicillins (ampicillin, amoxicillin, ... Acinetobacter baylyi, and gram-negative plant pathogens such as Ralstonia solanacearum and Xylella fastidiosa.[14] ...
... baumannii is commonly involved in nosocomial infections, but few therapeutic options are available. Find out what there is to ... Acinetobacter baumannii is a gram-negative aerobic bacillus that primarily causes hospital-acquired infections affecting ... Table 2. Recommended doses of antimicrobials for severe A. baumannii infections Antibiotic. Loading dose. Daily dose. Dose on ... Table 1. Risk factors for development of A. baumannii infections in the ICU Prior colonization with A. baumannii ...
Patients with Acinetobacter pneumonias occurring in the context of an outbreak in the intensive care unit (IC... more ... Prolonged hospitalization or antibiotic therapy predisposes to Acinetobacter colonization. ... Diagnosis of acinetobacter baumannii infections. Int J Prev Med. 2012 Nov. 3(11):817. [Medline]. [Full Text]. ... An outbreak of acinetobacter infection associated with the use of a ventilator spirometer. Respir Care. 1980 Feb. 25(2):232-7. ...
Nosocomial bloodstream infections due to Acinetobacter baumannii, Acinetobacter pittii and Acinetobacter nosocomialis in the ... Acinetobacter infection. N Engl J Med. 2008;358:1271-81.PubMedCrossRefGoogle Scholar ... Intravenous minocycline: a review in Acinetobacter infections. Drugs. 2016;76:1467-76.PubMedCrossRefGoogle Scholar ... Existing treatment options for infections due to Acinetobacter are limited by a lack of robust efficacy and safety data along ...
This topic contains 2 study abstracts on Acinetobacter baumannii infection indicating that the following substances may be ... 1 Abstracts with Acinetobacter baumannii infection & Raspberry root Research. [x] Remove Focus on Raspberry root. Filter by ... 1 Problem Substances Researched for Acinetobacter baumannii infection Name. AC. CK. Focus. ... Diseases : Anthrax, Bacillus anthracis, Carbapenem-resistant Acinetobacter baumannii (CRAB), MRSA. Pharmacological Actions : ...
According to reports, health officials are probing into bacterial infections in the ... ... A premature baby died while four others were found sick at a New Jersey hospital because of a bacterial infection. ... Premature Baby Who Contracted Acinetobacter Baumannii Bacterial Infection Dies At New Jersey Hospital Michal Jarmoluk / Pixabay ... Wade said that acinetobacter is a hospital-acquired infection with no community transmission, which means that it does not pose ...
Acinetobacter baumannii causes a wide range of nosocomial infections. This pathogen is considered a threat to human health due ... A Phenome-Wide Association Study Uncovers a Pathological Role of Coagulation Factor X during Acinetobacter baumannii Infection ... Acinetobacter baumannii is a Gram-negative bacterium that is associated with hospital-acquired and ventilator-associated ... 2-Hydroxylation of Acinetobacter baumannii Lipid A Contributes to Virulence ...
Against infections with Pseudomonas aeruginosa or Acinetobacter baumannii isolates that are resistant to all antibiotics except ... Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter ... However, against infections with species resistant to all antibiotics, including polymyxins, novel combinations are the only ... For infections with antibiotic-susceptible strains of Pseudomonas aeruginosa, most studies have suggested that combination ...
Pneumonia was the most common infection (43.5%), followed by skin and soft tissue infections (20.4%). Acinetobacter baumannii ... Clinical experience of tigecycline treatment in infections caused by extensively drug-resistant Acinetobacter spp.. Moon SY1, ... There are few data on clinical experience of tigecycline in hospital-acquired pneumonia (HAP) and Acinetobacter spp. infection. ... Tigecycline can be considered as an alternative therapy in patients with HAP or infections caused by Acinetobacter spp., ...
Acinetobacter baumannii is the cause of difficult-to-treat infections in healthcare settings in Europe due to its increasing ... Hospital Infections Kill 200 Daily in US: Study. In the United States, healthcare-associated infections kill 75,000 patients ... Efforts Needed to Stop the Spread of Acinetobacter Baumannii Infections in Europe. ... Infections with carbapenem-resistant A. baumannii occur in patients with severe underlying diseases, mainly in intensive care ...
HTF MI published a new industry research that focuses on Acinetobacter Infections Treatment market and delivers in-depth market ... Acinetobacter Infections Treatment Segment Market Analysis (by Type);. Chapter 7 and 8, to analyze the Acinetobacter Infections ... Acinetobacter Infections Treatment;. Chapter 12,13, 14 and 15, to describe Acinetobacter Infections Treatment sales channel, ... Specifications and Classification of Acinetobacter Infections Treatment, Applications of Acinetobacter Infections Treatment, ...
Recent Advances in the Immunopathogenesis of Acinetobacter baumannii Infection , IntechOpen, Published on: 2012-03-14. Authors ... Recent Advances in the Immunopathogenesis of Acinetobacter baumannii Infection. By Louis de Léséleuc and Wangxue Chen DOI: ... Medicine » Pulmonology » Pulmonary Infection, book edited by Amer Amal, ISBN 978-953-51-0286-1, Published: March 14, 2012 ...
The emergence of Acinetobacter infections in adult post-neurosurgical infections, multiple antibiotic resistant characteristics ... Of these 81 cases, Acinetobacter infection was found in 13 cases. Clinical and laboratory data of these Acinetobacter ... Adult Acinetobacter meningitis and its comparison with non-Acinetobacter gram-negative bacterial meningitis. ... A statistically significant difference between Acinetobacter meningitis and non-Acinetobacter GNBM included hydrocephalus and ...
A national alert was triggered in September 2003 when 4 hospitals reported clusters of A. baumannii infection with similar ... VEB-1 extended-spectrum beta-lactamase-producing Acinetobacter baumannii was responsible for an outbreak in hospitals in France ... From April 2003 through June 2004, 53 hospitals reported 290 cases of A. baumannii infection or colonization; 275 isolates were ... French Nosocomial Infection Early Warning Investigation and Surveillance Network ...
Acinetobacter community acquired pneumonia.. +6 More images of Acinetobacter infection with subscription ... Acinetobacter infection. Subscriber Sign In VisualDx Mobile Feedback Select Language Share Enter a Symptom, Medication, or ... Hospital outbreaks of multidrug-resistant Acinetobacter infections have been reported. A wide range of infections are possible ... 446156008 - Infection due to multidrug resistant Acinetobacter. Best Tests. Subscription Required. References. Subscription ...
This report describes a cluster of 34 carbapenem-resistant Acinetobacter baumannii cases in a New Jersey hospital that peaked ... This report describes a cluster of 34 carbapenem-resistant Acinetobacter baumannii cases in a New Jersey hospital that peaked ... Carbapenem-resistant Acinetobacter baumannii (CRAB) causes health care-associated infections that are challenging to contain ... Infection control programs and antibiotic control programs to limit transmission of multi-drug resistant Acinetobacter ...
Current State and Further Development of Animal Models of Serious Infections Caused by Acinetobacter baumannii and Pseudomonas ... Current State and Further Development of Animal Models of Serious Infections Caused by Acinetobacter baumannii and Pseudomonas ... Current State and Further Development of Animal Models of Serious Infections Caused by Acinetobacter baumannii and Pseudomonas ... Pathogenesis of Acinetobacter spp.: Resistance and Virulence Converge? (PDF - 2.6MB) - Robert A. Bonomo, M.D. ...
Clinical and Infection Control Implications - Volume 20 Issue 8 - Marie Eve Dy, Jill A. Nord, Vincent J. LaBombardi, Jay W. ... The Emergence of Resistant Strains of Acinetobacter baumannii: ... An outbreak of infections with Acinetobacter calcoaceticus in ... Typing of Acinetobacter baumannii isolated from hospital-acquired respiratory infections in a tertiary care centre in Southern ... Severe Acinetobacter baumannii Sepsis Is Associated with Elevation of Pentraxin 3. Infection and Immunity, Vol. 82, Issue. 9, p ...
... also known as Acinetobacter Baumannii Infection, is caused by the Acinetobacter baumannii bacteria. It can be spread by direct ... Skin or wound infection. Body systems harmed by Acinetobacter infection. An Acinetobacter baumannii infection can cause serious ... Acinetobacter infection, also known as Acinetobacter Baumannii Infection, is caused by the Acinetobacter baumannii bacteria. It ... Anyone can get an Acinetobacter baumannii infection. You are more likely to get an infection from Acinetobacter baumannii if ...
Background Multidrug resistant Acinetobacter baumanniiis one of the major infection agents causing nosocomial pneumonia. ... Acinetobacter baumannii is a widely spread opportunistic pathogen causing pneumonia, sepsis and soft tissue infections [1]. A. ... Multidrug resistant Acinetobacter baumannii is one of the major infection agents causing nosocomial pneumonia. Therefore, new ... Blp1 protein shows virulence-associated features and elicits protective immunity to Acinetobacter baumannii infection. ...
... according to a new study published in the November issue of the American Journal of Infection Control. ... Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 percent of the rooms of patients ... Acinetobacter baumannii is a species of gram-negative, multidrug resistant bacteria that has caused outbreaks of infection in ... Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 percent of the rooms of patients ...
... and outcomes of older adults with Acinetobacter infection in community hospitals. The researchers investigated the microbiology ... According to the article in Clinical Infectious Diseases, "During this period, Acinetobacter prevalence increased 25 percent. ... MultidrugResistant Acinetobacter baumannii: An Emerging Pathogen among Older Adults in Community Hospitals and Nursing Homes. ... Infection Control Today is part of the Global Exhibitions Division of Informa PLC ...
... the two most common manifestations of clinical infections with this pathogen ... This unit describes basic protocols for infecting mice through intranasal and intraperitoneal routes with Acinetobacter ... tissue infection models for the study of Acinetobacter baumannii biology. Infection and Immunity, 76(8), 3577-3586. doi: ... Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice. Infection ...
Concurrent Outbreak of Multidrug-Resistant and Susceptible Subclones of Acinetobacter baumannii Affecting Different Wards of a ... Multiresistant Acinetobacter infections: a role of sulbactam combinations in overcoming an emerging worldwide problem. Clin ... Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case control study of adult burn patients ... 4.Simor, AE, Lee, M, Vearncombe, M, et al.An outbreak due to multire-sistant Acinetobacter baumannii in a burn unit: risk ...
Eighteen had osteomyelitis, 2 burn infection, and 3 deep wound infection. Primary therapy for these infections was directed ... Patients were followed up to 23 months after completing therapy, and none had recurrent infection with Acinetobacter species. ... Acinetobacter species have been prevalent during the 2003-2005 military operations in Iraq. Twenty-three soldiers wounded in ... Iraq and subsequently admitted to our facility from March 2003 to May 2004 had wound cultures positive for Acinetobacter ...
Body lice that fed on rabbits infused with each Acinetobacter species demonstrated a generalized infection. The body lice did ... Previous studies have reported the isolation of Acinetobacter baumannii from the body lice of homeless patients. To study how ... An increased mortality rate was observed between the second and third days post-infection; however, they remained infected for ... The lice excreted living Acinetobacter species within their feces. Only the louse strain of A. baumannii was pathogenic for the ...
Pandrug-Resistant Acinetobacter baumannii Causing Nosocomial Infections in a University Hospital, Taiwan Po-Ren Hsueh*, Lee- ... Pandrug-Resistant Acinetobacter baumannii Causing Nosocomial Infections in a University Hospital, Taiwan. ... patterns generated by arbitrarily primed polymerase chain reaction for pandrug-resistant Acinetobacter baumannii (PDRAB) ...
The meropenem treatment outcome was similar in infections caused by the clinical and the heterogeneous isolates, irrespective ... baumannii isolates grown heterogeneously in the presence of meropenem and their virulence evaluated in experimental infections ... Acinetobacter baumannii may exhibit phenotypic heterogeneous growth under exposure to antibiotics. We investigated the in vitro ... isolates and the therapeutic efficacy of three meropenem dosing schemes was evaluated in a neutropenic murine thigh infection ...
... aeruginosa and Acinetobacter spp. Data correlating periodontal infection and P. aeruginosa or Acinetobacter spp. colonization ... Obana Y (1986) Pathogenic significance of Acinetobacter calcoaceticus: Analysis of experimental infection in mice. Microbiol ... Acinetobacter spp. are a major concern in nosocomial infections due to their rapid development of multi-drug resistance, ... of poor oral hygiene and periodontal infection. This study investigated the prevalence of P. aeruginosa and Acinetobacter spp. ...
As one of the ESKAPE pathogens, Acinetobacter baumannii is a frequently isolated organism from infections in clinical settings ... Personalized therapeutic cocktail of wild environmental phages rescues mice from Acinetobacter baumannii wound infections. ... Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev21:538-582. doi:10.1128/CMR.00058-07. ... Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection. ...
Acinetobacter seifertii sp. nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolated from ... Acinetobacter: portrait of a genus, p 1-24. In Towner KJ, Bergogne-Berezin E, Fewson CA (ed), The biology of Acinetobacter. ... Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models. FEMS Microbiol Rev 37:130- ... Genome dynamics of multidrug-resistant Acinetobacter baumannii during infection and treatment. Genome Med 8:26. doi:10.1186/ ...
  • Against infections with Pseudomonas aeruginosa or Acinetobacter baumannii isolates that are resistant to all antibiotics except the polymyxins, several novel antibiotic combinations demonstrate increased activity in vitro compared with that of any single agent. (nih.gov)
  • In May 2020, hospital A notified NJDOH of an increase in CRAB ( A. baumannii with meropenem minimum inhibitory concentration testing of ≥8 μ g/mL) isolates from weekly ICU point prevalence surveys (colonization screening) and from clinical infections. (cdc.gov)
  • Random amplified polymorphic DNA (RAPD) patterns generated by arbitrarily primed polymerase chain reaction for pandrug-resistant Acinetobacter baumannii (PDRAB) isolates using two primers OPA-05 (A) and OPA-02 (B). Lane M, molecular size marker. (cdc.gov)
  • These diseases involve a group of isolates represented by members of the " A. calcoaceticus-A. baumannii (Acb) complex," which are relevant to human health since they are associated with intra- and extranosocomial infections worldwide ( 9 ). (asm.org)
  • Many A. baumannii clinical isolates are also MDR, which severely restricts the available treatment options, with untreatable infections in traumatic wounds often resulting in prolonged healing times, the need for extensive surgical debridement, and in some cases the further or complete amputation of limbs ( 4 - 14 ). (asm.org)
  • For infections caused by multidrug-resistant isolates, antibiotic choices may be quite limited. (elsevier.com)
  • Indicated for complicated skin and skin structure infections caused by E coli, E faecalis (vancomycin-susceptible isolates only), S aureus (methicillin-susceptible and -resistant isolates), S agalactiae, S anginosus group (includes S anginosus, S intermedius, and S constellatus ), S pyogenes, and B fragilis . (medscape.com)
  • Most Acinetobacter isolates recovered from hospitalized patients, particularly those recovered from respiratory secretions and urine, represent colonization rather than infection. (medscape.com)
  • The presence of Acinetobacter isolates in respiratory secretions in intubated patients may represent colonization. (medscape.com)
  • In the UK, genotypes belonging to the Group 1 clonal complex have been particularly successful, accounting for the vast majority of isolates referred from hospitals experiencing problems with Acinetobacter. (nih.gov)
  • Estimation of occurrence of Acinetobacter baumannii isolates from the antimicrobial surveillance system of Emilia-Romagna, Italy, 2005-2009. (biomedcentral.com)
  • In a previous study, we showed that Acinetobacter genomic DNA group 3 was the most common species among blood culture isolates and was commonly found on superficial carriage sites of the healthy and the sick, which are different findings from those reported in Europe and North America. (asm.org)
  • Over a study period of 6 weeks with 136 consecutive routine clinical isolates (1.33% of all specimens), genomic DNA groups 2 ( Acinetobacter baumannii ), 3, and 13TU were obtained from 59 of 69 positive patients. (asm.org)
  • Molecular analysis of Acinetobacter baumannii isolates from invasive infections in 2009 in Poland. (semanticscholar.org)
  • The study was performed on 30 patient-unique isolates (Table 1) collected during a surveillance of invasive infections in Polish hospitals. (semanticscholar.org)
  • 99% conserved at the amino acid level across clinical isolates harvested between 1951 and 2009 from cerebrospinal fluid, blood, lung, and wound infections, including carbapenem-resistant isolates, and was ≥89% conserved among other sequenced strains, but had minimal homology to the human proteome. (mendeley.com)
  • Antimicrobial treatment of these clinical infections, particularly those caused by Acinetobacter baumannii strains, may be compromised by the multiple-drug resistance of many isolates to β-lactams, aminoglycosides, and fluoroquinolones ( 4 , 23 ). (asm.org)
  • During the last decade, hospital-acquired infections involving multiresistant A. baumannii isolates have been reported, often in association with contamination of the hospital equipment or cross-contamination by the colonized hands of patient-attending personnel ( 5 , 6 , 20 , 37-39 ). (asm.org)
  • The presence of clinical Acinetobacter baumannii (A. baumannii) isolates with differing antibiotic resistance phenotypes in the same patient causes difficulties and confusion in treatment. (biomedcentral.com)
  • Few (100) randomly selected isolates of Acinetobacter baumannii ( A. baumannii) were tested for imipenem, meropenem, and polymyxin B susceptibility by minimum inhibitory concentration (MIC) and for the presence of class A and B carbapenemases by multiplex PCR. (hindawi.com)
  • The majority of the isolates displayed a close evolutionary relationship, suggesting that serious nosocomial spreading and nosocomial infections of CRAB have occurred in the burn unit. (frontiersin.org)
  • One hundred fifty-seven (91.2%) of the isolates were involved in 14 different clusters.ConclusionsColistin is still the most effective antibiotic for A. baumannii infections. (comu.edu.tr)
  • The distribution of invasive A. baumannii isolates from different regions of Turkey is not diverse so, infection control measures at medical centers should be revised to decrease the MDR A. baumannii infections across the country. (comu.edu.tr)
  • To compare trends in antimicrobial consumption and development of resistance among isolates of Acinetobacter spp . (balkanmedicaljournal.org)
  • Because routine identification in the clinical microbiology laboratory is not yet possible, Acinetobacter isolates are divided and grouped into three main complexes: Acinetobacter calcoaceticus-baumannii complex: glucose-oxidising nonhemolytic (A. baumannii can be identified by OXA-51 typing) Acinetobacter lwoffii: glucose-negative nonhemolytic Acinetobacter haemolyticus: hemolytic Different species of bacteria in this genus can be identified using fluorescence-lactose-denitrification to find the amount of acid produced by metabolism of glucose. (wikipedia.org)
  • We reviewed recent data about epidemiology of Acinetobacter baumannii , resistance mechanisms, and therapeutic options for severe infections caused by multidrug-resistant strains. (medscape.com)
  • Garnacho-Montero J, Amaya-Villar R. Multiresistant Acinetobacter baumannii infections: epidemiology and management. (medscape.com)
  • Outbreak of a multiply resistant Acinetobacter in a surgical intensive care unit: epidemiology and control. (medscape.com)
  • Infection Control & Hospital Epidemiology, Vol. 22, Issue. (cambridge.org)
  • The Epidemiology of Multidrug-Resistant Acinetobacter Baumannii Does the Community Represent a Reservoir? (cambridge.org)
  • In their latest work, Sengstock and colleagues describe the epidemiology, resistance patterns, and outcomes of older adults with Acinetobacter infection in community hospitals. (infectioncontroltoday.com)
  • Present at the public meeting were consultants with wide-ranging expertise in areas such as human and veterinary medicine, pharmaceutical and diagnostics manufacturing, animal husbandry, clinical microbiology, epidemiology, infectious diseases and infection control, and state and local public health officials. (cdc.gov)
  • Epidemiology and Infection Control Implications ofAcinetobacter spp. (asm.org)
  • We used amplified ribosomal DNA restriction analysis and pulsed-field gel electrophoresis to study further the molecular epidemiology of acinetobacters in our region. (asm.org)
  • She hopes to continue developing her career in Hospital Epidemiology and Infection Control. (reflectionsipc.com)
  • abstract = "The molecular epidemiology of fifteen clinical strains of Acinetobacter baumannii recovered from various clinical specimens from different wards during January to June, 2010 from a hospital in Nepal was evaluated. (edu.au)
  • Ball pits used in children's physical therapy - similar to those made popular by restaurants catering to families - may contribute to germ transmission between patients, according to new research published in the American Journal of Infection Control, the journal of the Association for Professionals in Infection Control and Epidemiology, published by Elsevier. (news-medical.net)
  • New research finds curcumin combined with a polyphenol in green tea and other foods and herbs will inhibit multi-drug resistant Acinetobacter baumannii - often at the root of hospital-acquried pneumonia infections. (greenmedinfo.com)
  • Acinetobacter baumannii bacteria is known to cause pneumonia or serious blood or wound infections. (inquisitr.com)
  • Acinetobacter baumannii is a Gram-negative bacterium that is associated with hospital-acquired and ventilator-associated pneumonia. (asm.org)
  • Tigecycline has broad spectrum antimicrobial activity and is approved for complicated intra-abdominal infections, complicated skin and soft tissue infections, and community-acquired pneumonia. (nih.gov)
  • There are few data on clinical experience of tigecycline in hospital-acquired pneumonia (HAP) and Acinetobacter spp. (nih.gov)
  • A wide range of infections are possible with this organism, including bloodstream infections , pneumonia (occasionally even community-acquired pneumonia), urinary tract infections , and wound infections (wound infection in soldiers after traumatic injury have been reported). (visualdx.com)
  • Patients present with symptoms compatible with the site of infection (for example, patients with pneumonia will have respiratory symptoms compatible with pneumonia). (visualdx.com)
  • Acinetobacter community acquired pneumonia. (visualdx.com)
  • Acinetobacter baumannii colonizes the respiratory tract, skin, urinary and gastrointestinal systems, and frequently leads to pneumonia, blood circulatory infection, and urinary system infection. (naturalpedia.com)
  • Multidrug resistant Acinetobacter baumannii is one of the major infection agents causing nosocomial pneumonia. (springer.com)
  • Community-acquired Acinetobacter pneumonia: a case report. (ajtmh.org)
  • Objectives: In the intensive care setting, Acinetobacter baumannii causes ventilator-associated pneumonia and other nosocomial infections that are difficult to treat. (bezmialem.edu.tr)
  • A person who has become infected with Acinetobacter bacteria may develop pneumonia-like symptoms. (brighthub.com)
  • Acinetobacter baumannii can cause infections in the blood, urinary tract, and lungs (pneumonia), or in wounds in other parts of the body. (dalmatien.info)
  • Acinetobacter causes a variety of diseases, ranging from pneumonia to serious blood or wound infections, and the symptoms vary depending on the disease. (bscnnursesolomonmpanga.com)
  • However, in hospitals, some strains, notably Acinetobacter baumannii will cause infections together with pneumonia and bacteremia ( bloodstream infection ). (soundhealthsolution.com)
  • Pneumonia: Pneumonia is an infection of the lungs. (soundhealthsolution.com)
  • Your healthcare supplier could use an x-ray to seem for signs of pneumonia or different infections. (soundhealthsolution.com)
  • Entasis Therapeutics has initiated the pivotal Phase III ATTACK clinical trial of ETX2514SUL to treat pneumonia and bloodstream infections caused due to carbapenem-resistant Acinetobacter baumannii. (clinicaltrialsarena.com)
  • Part A of the Phase III study will involve patients with acinetobacter baumannii-calcoaceticus complex (ABC) hospital-acquired bacterial pneumonia, ventilator-associated bacterial pneumonia or bacteremia. (clinicaltrialsarena.com)
  • In fact, A. baumannii is now responsible for up to 20% of all intensive care unit infections in some regions of the world with pneumonia being the most common presentation. (grantome.com)
  • This proposal will define the strategies employed by the important human pathogen Acinetobacter baumannii to combat calprotectin-dependent zinc starvation during the pathogenesis of pneumonia. (grantome.com)
  • These infections may occur as outbreaks rather than isolated cases of nosocomial pneumonia. (medscape.com)
  • The 2005 IDSA guidelines for hospital-acquired pneumonia discuss the role of Acinetobacter as a cause of nosocomial pneumonia. (medscape.com)
  • Acinetobacter bumannii causes different hospital-aquired infections, such as bacteremia, urinary tract infections, and secondary meningitis, but its prominent role is in hospital pneumonia, especially pneumonia of the upper respiratory tract of patients in intensive care units. (intjinfection.com)
  • Background The impact of appropriate antimicrobial therapy for A. baumannii bacteremic pneumonia has not been well established due to the inclusion of the three phenotypically indistinguishable Acinetobacter species and confounding factors including underlying diseases and severity of infection. (researchsquare.com)
  • Antimicrobial stewardship programs are essential to combat this unpredictable pathogen through use of infection prevention, rapid diagnostics, antibiogram-optimized treatment regimens, and avoidance of overuse of antimicrobials. (springer.com)
  • The drug development pipeline includes several agents with encouraging in vitro activity against Acinetobacter , but their place in therapy and contribution to the armamentarium against this pathogen remain to be defined. (springer.com)
  • The objective of this review is to highlight the unique challenge of treating infections due to Acinetobacter and summarize recent literature regarding optimal antimicrobial treatment for this pathogen. (springer.com)
  • Carbapenem-resistant Acinetobacter baumannii (CRAB), an opportunistic pathogen primarily associated with hospital-acquired infections, is an urgent public health threat ( 1 ). (cdc.gov)
  • Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 percent of the rooms of patients colonized or infected with the pathogen, according to a new study published in the November issue of the American Journal of Infection Control. (infectioncontroltoday.com)
  • Since the study was conducted, new strategies to reduce transmission of the pathogen have resulted in a significant decrease in infections and acquisition. (infectioncontroltoday.com)
  • Infections from this pathogen primarily occur in very ill, wounded or immunocompromised patients. (infectioncontroltoday.com)
  • Multidrug Resistant Acinetobacter baumannii: An Emerging Pathogen among Older Adults in Community Hospitals and Nursing Homes. (infectioncontroltoday.com)
  • Acinetobacter baumannii has emerged as an opportunistic pathogen among acutely ill patients, especially those with thermal injury. (cambridge.org)
  • Acinetobacter baumannii remains an important and difficult-to-treat pathogen whose resistance patterns result in significant challenges for the clinician. (oup.com)
  • The gram-negative coccobacillus acinetobacter, a pathogen once seen only in hot, humid climates, has become an increasingly common nosocomial problem even in temperate climates. (elsevier.com)
  • Acinetobacter baumannii is an important nosocomial pathogen that causes a range of diseases, including respiratory and urinary tract infections, meningitis, endocarditis, wound infections, and bacteremia. (grantome.com)
  • Primarily responsible for nosocomial infections, Acinetobacter baumannii has become a challenging pathogen to treat, with multi-drug resistant strains (MDR-AB) now widespread. (infectweb.com)
  • To examine the role of zinc at the host-pathogen interface we utilised a murine model of zinc deficiency and challenge with wild-type and czcA mutant cells, which identified highly site-specific roles for zinc during A. baumannii infection. (edu.au)
  • Suspicion of bloodstream infection warrants immediate blood tests, and if bloodstream infection is confirmed, pathogen-based treatment should be initiated immediately. (jjmicrobiol.com)
  • Acinetobacter is a well-recognized nosocomial pathogen. (cambridge.org)
  • This bacterium is known as a tropical and humid pathogen, and the prevalence of infection in the summer is higher than in other seasons ( 10 , 11 ). (intjinfection.com)
  • Multi-drug resistant (MDR) Acinetobacter baumannii is a major nosocomial pathogen causing a wide range of clinical conditions with significant mortality rates. (frontiersin.org)
  • Extreme-drug-resistant (XDR) Acinetobacter baumannii is a rapidly emerging pathogen causing infections with unacceptably high mortality rates due to inadequate available treatment. (mendeley.com)
  • The emergence of multi-drug resistant oligoclonal population of this pathogen in a hospital warrants for development of appropriate antibiotic policies and immediate implementation of infection prevention and control measures. (edu.au)
  • After the selection of clinically relevant questions, this document provides recommendations about the use of microbiological techniques for identification of A. baumannii in clinical laboratories, antibiotic therapy for severe infections and recommendations to control this pathogen in outbreaks and endemic situations. (elsevier.com)
  • BACKGROUND: Acinetobacter baumanii (A. baumanii ) remains an important microbial pathogen resulting in nosocomial acquired infections with significant morbidity and mortality. (mendeley.com)
  • One such MDRO that has rapidly reached the level of a 'significant pathogen' from a commensal of 'little significance' is Acinetobacter spp. (hindawi.com)
  • Acinetobacter baumannii is a leading pathogen responsible for nosocomial infections. (frontiersin.org)
  • For infections with antibiotic-susceptible strains of Pseudomonas aeruginosa, most studies have suggested that combination therapy, usually with a beta -lactam antibiotic plus an aminoglycoside, is preferable for patients with bacteremia and neutropenia. (nih.gov)
  • The incidence of bacteremia at military medical facilities caused by Acinetobacter baumannii has also increased ( 2 ). (cdc.gov)
  • There are a variety of microorganisms that cause health care-associated infections and ultimately, put patients at … We describe four cases of monomicrobial and polymicrobial A. baumannii-associated necrotizing SSTI accompanied by A. baumannii bacteremia and offer a review of similar experiences published in the literature. (dalmatien.info)
  • bacteremia (6), and urinary tract infection (3). (blogspot.com)
  • It also causes life-threatening infections among neonates, including bacteremia. (erciyes.edu.tr)
  • This resistance often leads to devastatingly long delays in time to appropriate therapy and increased mortality for patients afflicted with Acinetobacter infections. (springer.com)
  • Thirty-day mortality rate of HAP and Acinetobacter spp. (nih.gov)
  • Mortality and morbidity resulting from A baumannii infection relate to the underlying cardiopulmonary immune status of the host rather than the inherent virulence of the organism. (medscape.com)
  • Ventricular infection due to XDR- Acinetobacter baumanii ( A. baumanii ) is the most severe complication after neurosurgery which associated with high morbidity and mortality. (panafrican-med-journal.com)
  • Malfunction of ventriculo peritoneal (VP) shunt or external ventricular drainage (EVD) insertion closely related with post-neurosurgical infection which leads to longer hospitalization stay, higher costs, morbidity and mortality rate [ 1 , 2 ]. (panafrican-med-journal.com)
  • Mortality in infected patients was higher compared with those without infection (relative risk = 2.86, p = 0.001). (elsevier.com)
  • On multivariate analysis, infection with Acb was not statistically associated with mortality. (elsevier.com)
  • A retrospective case series of acinetobacter infections at a tertiary hospital in Nairobi was conducted to determine the mortality rate and factors associated with mortality. (aku.edu)
  • The mean Sequential Organ Failure Assessment score was associated with mortality from acinetobacter infections. (aku.edu)
  • In one of the largest studies to measure the burden of antibiotic resistance in a low- or middle-income country, researchers at the Center for Disease Dynamics, Economics & Policy report that in-hospital mortality is significantly higher among patients infected with multi-drug resistant or extensively drug resistant pathogens including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii. (news-medical.net)
  • A substantial number of reports received from hospitals across the world is warning of the alarming spread of antibiotic-resistant bacteria causing nosocomial infections (NIs), which has led to increases in both costs and mortality (1-3). (balkanmedicaljournal.org)
  • Which clinical history findings are characteristic of Acinetobacter infection? (medscape.com)
  • Wong D, Nielsen T, Bonomo R, Pantapalangkoor P, Luna B, Spellberg B. Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges. (medscape.com)
  • Impact of multi-drug-resistant Acinetobacter baumannii on clinical outcomes. (medscape.com)
  • Clinical experience of tigecycline treatment in infections caused by extensively drug-resistant Acinetobacter spp. (nih.gov)
  • Clinical and laboratory data of these Acinetobacter meningitis patients were studied and were compared with those of other 68 non-Acinetobacter Gram-negative bacterial meningitis (GNBM) patients. (uptodate.com)
  • The researchers investigated the microbiology databases at Oakwood Healthcare System in Michigan (four hospitals with 632, 259, 199 and 168 beds) for clinical Acinetobacter cultures obtained from 2003 to 2008. (infectioncontroltoday.com)
  • According to the article in Clinical Infectious Diseases , "During this period, Acinetobacter prevalence increased 25 percent. (infectioncontroltoday.com)
  • This case series reviews 1 military medical center's experience with these infections, including species identified, antimicrobial drug-susceptibility patterns, antimicrobial drug therapy, and clinical outcomes. (cdc.gov)
  • The present study aimed to perform a deep phenotypic and genotypic analysis of 15 clinical carbapenem-resistant Acinetobacter baumannii (CRAb) strains isolated in Madagascar between 2008 and 2016 from diverse sources. (biomedcentral.com)
  • Differentiation of Acinetobacter species is difficult with the means typically available to most clinical microbiology laboratories, including commercial semiautomated identification systems. (mhmedical.com)
  • While routine clinical diagnostic laboratories often have difficulties in differentiating A. baumannii from other Acinetobacter spp. (dalmatien.info)
  • Laboratory: A blood cell count is nonspecific and leukocytosis is not a universal clinical feature of infections with Acinetobacter. (medigoo.com)
  • The organism may be cultured from routine clinical specimens, cerebrospinal fluid, blood, respiratory secretions, peritoneal fluid, wound exudates, or urine.Imaging: Chest radiograph and CT scans are useful in defining the extent of a nosocomial infection by any organism or to rule out other causes of the patient's symptoms.Other tests: These tests would be related to the organ system involved. (medigoo.com)
  • Identifying Acinetobacter in the absence of clinical signs of infection may represent colonization, which does not warrant treatment. (medigoo.com)
  • Entasis Therapeutics CEO Manos Perros said: "It is the culmination of extensive preclinical development and multiple Phase I and II clinical trials, which have shown that ETX2514SUL has great potential for the treatment of patients with carbapenem-resistant A. baumannii infections. (clinicaltrialsarena.com)
  • To describe the clinical and microbiologic outcomes of patients who received tigecycline for the treatment of infections caused by Acinetobacter spp. (blogspot.com)
  • We present a detailed clinical course of a persistent blood-stream infection due to A. baumannii . (jjmicrobiol.com)
  • Goal 7: Facilitate clinical research to improve the treatment and prevention of antimicrobial drug resistant infections. (cdc.gov)
  • Acinetobacter baumannii (A. baumannii) infections became an emerging health concern in hospitals across the globe and are often related to nosocomial infections with poorer clinical outcomes in patients with prolonged hospital stay. (ekb.eg)
  • The effect of multidrug-resistant (MDR) Acinetobacter infection on clinical outcomes has not been reported. (elsevier.com)
  • Methods: Clinical microbiologists, infectious disease specialists and intensive care physicians were invited by the Chair of the Infection Section of the ESICM to participate in a multidisciplinary expert panel. (elsevier.com)
  • Evidence supporting each statement was graded according to the European Society of Clinical Microbiology and Infection Diseases (ESCMID) grading system. (elsevier.com)
  • Shionogi & Co., Ltd. announced today that The Lancet Infectious Diseases journal has published clinical results from the pivotal randomized controlled trial evaluating cefiderocol for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections. (news-medical.net)
  • In the first national study of the prevalence of antibiotic-resistant Acinetobacter baumannii infections in children across the US, researchers from Center for Disease Dynamics, Economics, & Policy (CDDEP) in Washington, DC and Rush University in Chicago, IL examined national and regional trends of antibiotic resistance in clinical specimens over a 13-year period. (news-medical.net)
  • The morphology of Acinetobacter species can be quite variable in Gram-stained human clinical specimens, and cannot be used to differentiate Acinetobacter from other common causes of infection. (wikipedia.org)
  • Patients with Acinetobacter pneumonias occurring in the context of an outbreak in the intensive care unit (ICU) generally have a history of preceding contact with respiratory support monitors or equipment. (medscape.com)
  • Nosocomial respiratory tract infection and colonization with Acinetobacter calcoaceticus. (medscape.com)
  • An outbreak of Acinetobacter respiratory tract infection resulting from incomplete disinfection of ventilatory equipment. (medscape.com)
  •   Respiratory Bacterial infections due to Acinetobacter species are typically encountered in health care settings and can be particularly difficult to treat due to the propensity of the organism to incorporate multiple antibiotic resistance mechanisms. (visualdx.com)
  • The oral cavity may be a major source of these respiratory pathogens, particularly in the presence of poor oral hygiene and periodontal infection. (scielo.br)
  • It can also "colonize" or live in a patient without causing infections or symptoms, especially in respiratory secretions (sputum) or open wounds. (dalmatien.info)
  • Colonization with Acinetobacter occurs on skin, wounds, and respiratory epithelium. (medigoo.com)
  • When Acinetobacter infections occur, they usually involve organ systems that have a high fluid content (eg, respiratory tract, CSF, peritoneal fluid, urinary tract). (medscape.com)
  • Acinetobacter pneumonias occur in outbreaks and are usually associated with colonized respiratory-support equipment or fluids. (medscape.com)
  • Bloodstream infection, followed by respiratory tract and surgical wound infections, is the most significant infection caused by A. baumannii ( 2 ). (jjmicrobiol.com)
  • Although this bacterium usually has low virulence, infected catheters cause a variety of infections and are often related to this respiratory system infection ( 9 ). (intjinfection.com)
  • As environmental pollution and population aging intensify in China, there will be higher incidences of the main indications for Levofloxacin, for example, respiratory infection, urinary infection and intestinal infection. (researchandmarkets.com)
  • The aim in this study was to investigate the spread status of antibiotic resistance genes, such as multiple beta-lactamase genes and aminoglycoside-modifying enzyme genes, from A. baumanii strains isolated from patients with lower respiratory tract infections (LRTIs). (mendeley.com)
  • Patients with Acinetobacter colonization often have a history of prolonged hospitalization or antimicrobial therapy (with antibiotics that have little or no activity against Acinetobacter ). (medscape.com)
  • However, against infections with species resistant to all antibiotics, including polymyxins, novel combinations are the only remaining therapeutic option. (nih.gov)
  • While carbapenems traditionally were the antibiotics of choice for treatment of A. baumannii infections, resistance to these drugs has led to increased use of colistin as last-line treatment. (medindia.net)
  • The difficulty that medical personnel have when an Acinetobacter infection occurs is that it can be resistant to antibiotics. (brighthub.com)
  • The infection is treated with antibiotics. (brighthub.com)
  • Like many pathogens common in health care settings, Acinetobacter baumannii has developed resistance to antibiotics and can be difficult to treat and prevent its spread. (dalmatien.info)
  • Additionally, because A. baumannii infections are so common in health care settings, many of the strains have become resistant to antibiotics and are harder to kill and prevent from spreading. (dalmatien.info)
  • Acinetobacter is often resistant to many commonly prescribed antibiotics. (bscnnursesolomonmpanga.com)
  • A group of microorganism found in soil, water, and hospitals wherever they will cause serious infections in upset people and are usually resistant to antibiotics. (soundhealthsolution.com)
  • This review summarizes the approaches to treatment and the current understanding of the ability of acinetobacter to accumulate diverse mechanisms of resistance, with the emergence of strains resistant to all commercially available antibiotics. (elsevier.com)
  • The predominant predispositions to infection include colonization pressure, exposure to broad-spectrum antibiotics, and disruption of anatomical barriers. (medscape.com)
  • Acinetobacter infections resistant to multiple classes of antibiotics have become prevalent in many institutions. (blogspot.com)
  • Managing A. baumanii ventriculitis/shunt infection and multiple brain abscesses is challenging since its nature that tends to be pandrug resistant to all antibiotics used. (panafrican-med-journal.com)
  • When co-administered with certain intravenous (IV) beta-lactam antibiotics, it is expected that SYN-004 can degrade the antibiotic that is excreted in the gastrointestinal (GI) tract, thus preserving the natural balance of the patient's microflora, and preventing opportunistic infections including CDI and antibiotic-associated diarrhea (AAD). (prnewswire.com)
  • We need new antibiotics, we also need better infection control - infection control interventions can be expensive," said Dr. Anthony Harris, who has done several NIH funded research studies on acinetobacter at the University of Maryland Medical Center. (pbs.org)
  • Although overuse of antibiotics helped create the superbug version of acinetobacter, finding new antibiotics is one important key to controlling it, doctors believe. (pbs.org)
  • The only antibiotics that usually work against multidrug resistant acinetobacter are colistin and sometimes refampin or tigecycline, all of which are highly toxic. (pbs.org)
  • A bill was introduced to Congress in July to provide incentive funding for the development of new antibiotics to treat these drug-resistant bacteria, including acinetobacter. (pbs.org)
  • It isn't a choice of antibiotics or infection control prevention or immunotherapy or environmental decontamination. (pbs.org)
  • A multifaceted intervention is needed to decrease the incidence rate of Acinetobacter and Pseudomonas hospital infections, as well as their resistance density to available antibiotics. (balkanmedicaljournal.org)
  • The incidence rate of infections caused by Acinetobacter or Pseudomonas , as well as their resistance density to commonly used antibiotics, were calculated. (balkanmedicaljournal.org)
  • Update on acinetobacter species: mechanisms of antimicrobial resistance and contemporary in vitro activity of minocycline and other treatment options. (medscape.com)
  • Acinetobacter remains one of the most challenging pathogens in the field of infectious diseases owing primarily to the uniqueness and multiplicity of its resistance mechanisms. (springer.com)
  • Of these resistant organisms, Acinetobacter remains one of the most formidable opponents, as its unique and eclectic resistance mechanisms allow it to escape the activity of the majority of our currently available antimicrobials. (springer.com)
  • Acinetobacter baumannii was isolated from 83 patients (76.9%) accounting for 50.3% of isolated pathogens, showing a resistance rate of 67.5% to carbapenems. (nih.gov)
  • A. baumannii is the cause of difficult-to-treat infections in healthcare settings in Europe due to its increasing resistance to antimicrobial agents, in particular the carbapenems. (medindia.net)
  • Although there is already a high resistance baseline in some countries, there has been an overall increase of carbapenem-resistant Acinetobacter baumannii in Europe. (medindia.net)
  • A statistically significant difference between Acinetobacter meningitis and non-Acinetobacter GNBM included hydrocephalus and ceftazidime-resistance. (uptodate.com)
  • Despite the drug resistance that infecting organisms demonstrated in this series, a regimen of carefully selected extended antimicrobial-drug therapy appears effective for osteomyelitis caused by MDR Acinetobacter spp. (cdc.gov)
  • Such infections are challenging to treat because of extensive antimicrobial drug resistance. (cdc.gov)
  • Acinetobacter baumannii is particularly formidable because of its propensity to acquire antibiotic resistance determinants. (mhmedical.com)
  • Objective of this study was to investigate nosocomial A. baumannii infections and its changing antibiotic resistance. (bezmialem.edu.tr)
  • Acinetobacter baumannii is a gram-negative bacterium known to cause severe infections and exhibit increasing rates of antibiotic resistance. (clinicaltrialsarena.com)
  • A generic β-lactam, sulbactam is known to exhibit intrinsic antibacterial activity against acinetobacter baumannii but is associated with β-lactamase-mediated resistance. (clinicaltrialsarena.com)
  • Outer membrane protein 33 (Omp33) is an outer membrane porin of Acinetobacter baumannii associated with carbapenem resistance. (nih.gov)
  • Acinetobacter infections have increased and gained attention because of the organism's prolonged environmental survival and propensity to develop antimicrobial drug resistance. (elsevier.com)
  • He agrees that antibiotic resistance and the ability to change itself are some of the biggest problems with treating acinetobacter. (pbs.org)
  • Characterization of a Nosocomial Outbreak Caused by a Multiresistant Acinetobacter baumannii Strain with a Carbapenem-Hydrolyzing Enzyme: High-Level Carbapenem Resistance inA. (asm.org)
  • View the published article at Antimicrobial Resistance and Infection Control . (researchsquare.com)
  • Several factors like over the counter antibiotic use, overcrowding in hospitals, imperfect infection control practices, and use of excessive invasive devices contribute to the development of high antimicrobial resistance, especially in developing countries [ 2 ]. (hindawi.com)
  • Previous Antibiotic Exposure and Antimicrobial Resistance Patterns of Acinetobacter spp. (balkanmedicaljournal.org)
  • This study showed that there is an association between the resistance density of Acinetobacter spp. (balkanmedicaljournal.org)
  • A statistically significant increase in resistance density in 2015 compared to the first year of observation was noted for Acinetobacter , but not for Pseudomonas , to third-generation cephalosporins (p=0.008), aminoglycosides (p=0.005), carbapenems (p=0.003), piperacillin/tazobactam (p=0.025), ampicillin/sulbactam (p=0.009) and tigecycline (p=0.048). (balkanmedicaljournal.org)
  • Thapa, BK & Tribuddharat, C 2011, ' Emergence of oligoclonal Acinetobacter baumannii nosocomial infection in a Hospital in Nepal ', African Journal of Microbiology Research , vol. 5, no. 32, pp. 5872-5876. (edu.au)
  • A group in the Department of Immunology, Microbiology and Parasitology at the UPV/EHU has conducted an in-depth study into the capacity to survive of the Acinetobacter baumannii bacterium as well as the strategies it uses to survive. (news-medical.net)
  • Twenty-three soldiers wounded in Iraq and subsequently admitted to our facility from March 2003 to May 2004 had wound cultures positive for Acinetobacter calcoaceticus-baumannii complex. (cdc.gov)
  • Compared to HCA infections, non-HCA infections were more often caused by Acinetobacter species other than calcoaceticus-baumannii complex species and by antibiotic-susceptible organisms. (cambridge.org)
  • Background: Acinetobacter calcoaceticus-baumannii complex (Acb) is recognized as an important cause of nosocomial infections. (elsevier.com)
  • Adult patients treated with tigecycline regardless of their source of infection or pathogens were enrolled. (nih.gov)
  • Conclusions: Peptide A3-APO, with an intramuscular therapeutic index of 15, is more efficacious and less toxic than any existing burn injury infection therapy modality against multidrug-resistant Gram-negative pathogens. (elsevier.com)
  • This strategy is based on the fact that all bacterial pathogens require nutrient metal in order to colonize their hosts, and alterations in dietary metal levels profoundly affect susceptibility to infection. (grantome.com)
  • DESCRIPTION (provided by applicant): In the last decade, Acinetobacter baumannii has emerged as one of the most highly antibiotic-resistant pathogens in the United States (US) and throughout the world. (sbir.gov)
  • are important nosocomial pathogens associated with a growing number of hospital-acquired infections worldwide ( 2 , 14 ). (asm.org)
  • are opportunistic pathogens with increasing relevance in nosocomial infections ( 6 ). (asm.org)
  • Clinically important pathogens such as Acinetobacter spp . (balkanmedicaljournal.org)
  • The optimal treatment for multidrug-resistant A. baumannii nosocomial infections has not been established. (medscape.com)
  • Antibiotic-resistant Acinetobacter meningitis in neurosurgical patients. (medscape.com)
  • Neonakis IK, Spandidos DA, Petinaki E. Confronting multidrug-resistant Acinetobacter baumannii: a review. (medscape.com)
  • Optimal therapy for multidrug-resistant Acinetobacter baumannii. (medscape.com)
  • Pharmacokinetic considerations regarding tigecycline for multidrug-resistant (MDR) Klebsiella pneumoniae or MDR Acinetobacter baumannii urosepsis. (medscape.com)
  • Treatment of nosocomial meningitis due to a multidrug resistant Acinetobacter baumannii with intraventricular colistin. (medscape.com)
  • Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter species. (nih.gov)
  • Outbreaks of carbapenem-resistant Acinetobacter baumannii in healthcare facilities have been reported in Europe and worldwide. (medindia.net)
  • Infections with carbapenem-resistant A. baumannii occur in patients with severe underlying diseases, mainly in intensive care units, and are often related to invasive procedures or indwelling devices. (medindia.net)
  • The emergence of Acinetobacter infections in adult post-neurosurgical infections, multiple antibiotic resistant characteristics, and the emergence of PDRAB strain remained a challenge of the initial management of this specific meningitis. (uptodate.com)
  • Hospital outbreaks of multidrug-resistant Acinetobacter infections have been reported. (visualdx.com)
  • Carbapenem-resistant Acinetobacter baumannii (CRAB) causes health care-associated infections that are challenging to contain and often linked to infection prevention and control (IPC) breaches. (cdc.gov)
  • Hospitals managing surges of patients with COVID-19 might be vulnerable to outbreaks of multidrug-resistant organism (MDRO) infections. (cdc.gov)
  • Hospital A and the New Jersey Department of Health (NJDOH) conducted an investigation, and identified 34 patients with hospital-acquired multidrug-resistant CRAB infection or colonization during February-July 2020, including 21 (62%) who were admitted to two intensive care units (ICUs) dedicated to caring for COVID-19 patients. (cdc.gov)
  • Research from the Center for Immunology and Infectious Disease at the Queen Mary University of London has determined that curcumin , the medically active compound from the turmeric root, can significantly inhibit antibiotic-resistant forms of Acinetobacter baumannii when combined with a compound found in a number of vegetables, herbs, and nuts. (naturalpedia.com)
  • Acinetobacter baumannii is a species of gram-negative, multidrug resistant bacteria that has caused outbreaks of infection in healthcare facilities over the last decade and considerable concern in the medical community. (infectioncontroltoday.com)
  • War wound infection and osteomyelitis caused by multidrug-resistant (MDR) Acinetobacter species have been prevalent during the 2003-2005 military operations in Iraq. (cdc.gov)
  • This relative increase of wounded casualties has led to an increased incidence of war wound infection and osteomyelitis, especially caused by multidrug-resistant (MDR) Acinetobacter species. (cdc.gov)
  • Rivera G, Bulnes J, Castillo C, Ajenjo MC, Garcia P, Labarca J (2016) Extensively drug-resistant Acinetobacter baumannii isolated in a university hospital: Role of inter-hospital transmission. (jidc.org)
  • Outbreaks of infection caused by strains of A. baumannii resistant to multiple antibiotic classes, including carbapenems, are a serious concern in many specialized hospital units, including intensive care units (ICUs). (mhmedical.com)
  • outbreaks of carbapenem-resistant A. baumannii infection occurred in a hospital in New York City. (mhmedical.com)
  • Multidrug-resistant Acinetobacter baumannii infection has presented a global medical challenge. (oup.com)
  • Our study provides valuable information for potential expansion of our current therapeutic options against colistin-resistant A. baumannii infection. (oup.com)
  • For example, a number of soldiers who were involved Operation Iraqi Freedom and Operation Enduring Freedom developed an Acinetobacter infection that was multidrug resistant. (brighthub.com)
  • ETX2514SUL has great potential for the treatment of patients with carbapenem-resistant A. baumannii infections. (clinicaltrialsarena.com)
  • Acinetobacter baumannii is a major cause of multidrug-resistant nosocomial infections. (microbiologyresearch.org)
  • Siegel JD , Rhinehart E , Jackson M , Chiarello L . the Healthcare Infection Control Practices Advisory Advisory Committee Management of multidrug-resistant in healthcare settings, 2006. (microbiologyresearch.org)
  • For gram-negative bacterial coverage of infections resistant to gentamicin and tobramycin. (medscape.com)
  • Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection. (blogspot.com)
  • Goal 1: Improve the detection, monitoring, and characterization of drug-resistant infections in humans and animals. (cdc.gov)
  • Goal 6: Facilitate the translation of basic research findings into practical applications for the prevention, diagnosis and treatment of resistant infections. (cdc.gov)
  • Many strains of Acinetobacter are multidrug-resistant and pose an increasing global threat to hospitalized patients, wounded military personnel and those affected by natural disasters. (prnewswire.com)
  • Dr. Spellberg's NIH-funded laboratory studies highly drug-resistant infections in an effort to develop vaccines and immune therapies to prevent and treat them. (prnewswire.com)
  • Dr. Spellberg is also the author of Rising Plague: The Global Threat from Deadly Bacteria and Our Dwindling Arsenal to Fight Them , which he wrote to inform and educate the public about the crisis in antibiotic resistant infections and lack of antibiotic development. (prnewswire.com)
  • The temporal trends of A. baumannii infections are driven by carbapenem-resistant strains. (biomedcentral.com)
  • A regional-wide outbreak of carbapenem-resistant A. baumannii infections involving 4 hospital trust was observed in Emilia-Romagna in 2009. (biomedcentral.com)
  • In fact, the drug is effective against multidrug resistant gram negative organisms, including Acinetobacter baumannii (AB). (leinfections.com)
  • Background: Extensively resistant Acinetobacter baumannii has emerged and spread worldwide as a significant cause of health care-associated infections and outbreaks. (erciyes.edu.tr)
  • The clinically important species, such as Acinetobacter baumannii (genomic DNA group 2), are intrinsically resistant to the first-line antimicrobial agents, e.g., ampicillin and cefuroxime. (asm.org)
  • Conclusions: Multidrug-resistant Acb is a common cause of nosocomial infection in the burn patient population. (elsevier.com)
  • Infection with antibiotic-resistant Acinetobacter spp. (ox.ac.uk)
  • The role of "colonization pressure" in the spread of vancomycin-resistant enterococci: an important infection control variable. (reflectionsipc.com)
  • An increasing number of infections caused by the pathogenic and multi-drug-resistant bacterium Acinetobacter baumannii has been reported in patients at military medical facilities in which service members were injured in the Iraq/Kuwait region during Operation Iraqi Freedom and in Afghanistan during Operation Enduring Freedom. (sbir.gov)
  • From February to November 1997, 29 inpatients at Ramón y Cajal Hospital, Madrid, Spain, were determined to be either colonized or infected with imipenem- and meropenem-resistant Acinetobacter baumannii (IMRAB) strains (MICs, 128 to 256 μg/ml). (asm.org)
  • The antibiotic-resistant Acinetobacter baumannii bacterium is one of the most globally harmful bacteria that causes nosocomial infections. (news-medical.net)
  • Antibiotic-resistant Acinetobacter baumannii infections, one of the most common hospital-acquired infections in children across the United States, are on the rise, according to results of a recent study published in the Journal of the Pediatric Infectious Diseases Society on March 22. (news-medical.net)
  • Subsequently, the prevalence of carbapenem-resistant Acinetobacter infections has increased r. (biomedcentral.com)
  • Multi-drug resistant coagulaso-negative staphylococci (CNS) have become an increasing problem in nosocomial infections connected with the presence of medical devices. (biomedcentral.com)
  • High Prevalence and Endemicity of Multidrug Resistant Acinetobacter spp. (hindawi.com)
  • Specific interventional measures should be adopted to control these imipenem resistant Acinetobacter spp. (hindawi.com)
  • 3 ]. The tremendous ability of this organism to accumulate antibiotic resistant determinants in response to antibiotic challenges and resist adverse conditions causing initial colonization and subsequent infection is really bothersome [ 4 ]. (hindawi.com)
  • Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. (cumhuriyet.edu.tr)
  • Objectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp. (cumhuriyet.edu.tr)
  • BackgroundMultidrug-resistant (MDR) Acinetobacter baumannii infections are considered as emerging nosocomial infections particularly in patients hospitalized in intensive care units (ICUs). (comu.edu.tr)
  • The alarming spread of antibiotic-resistant bacteria causing healthcare-associated infections has been extensively reported in recent medical literature. (balkanmedicaljournal.org)
  • Both Acinetobacter and Pseudomonas are inherently resistant to many drugs, but can also become resistant to almost any antimicrobial agent. (balkanmedicaljournal.org)
  • The second part will recruit subjects with ABC infections who have failed colistin therapy. (clinicaltrialsarena.com)
  • Here we compare the efficacy of the peptide with that of imipenem and colistin in A. baumannii wound infections after burn injury. (elsevier.com)
  • Colistin, the most commonly used agent for acinetobacter, can cause severe kidney and neurological damage and is considered an antibiotic of last resort. (pbs.org)
  • It may also cause urinary tract and skin and soft-tissue or wound infections. (naturalpedia.com)
  • Hospitalized patients, especially very ill patients on a ventilator, those with a prolonged hospital stay, those who have open wounds, or any person with invasive devices like urinary catheters are also at greater risk for Acinetobacter infection. (bscnnursesolomonmpanga.com)
  • It may additionally cause urinary tract and wound infections. (soundhealthsolution.com)
  • Urinary tract infection: A urinary tract infection (UTI) is an infection of the kidneys, ureters, or bladder. (soundhealthsolution.com)
  • Previously, ETX2514 with sulbactam was studied in single and multi-ascending dose Phase I trials and a Phase II trial for complicated urinary tract infections. (clinicaltrialsarena.com)
  • Similarly, Acinetobacter urinary tract infections are clinically indistinguishable from catheter-associated bacteremias caused by other aerobic gram-negative bacilli. (medscape.com)
  • Acinetobacter colonization is particularly common in patients who are intubated and in those who have multiple intravenous lines or monitoring devices, surgical drains, or indwelling urinary catheters. (medscape.com)
  • Prevalence of Pseudomonas aeruginosa and Acinetobacter spp. (scielo.br)
  • This study investigated the prevalence of P. aeruginosa and Acinetobacter spp. (scielo.br)
  • Despite the prevalence and interest in A. baumannii infections, there is relatively limited wellcontrolled scientific data to help the clinician select optimal empirical and subsequent targeted therapy for a variety of infections. (oup.com)
  • Although the prevalence of carbapenemase-producing Acinetobacter baumannii (CP-AB) in Germany is still low an increasing number of outbreaks has been reported in recent years. (biomedcentral.com)
  • This study was a laboratory-based audit to determine the prevalence of Acinetobacter spp. (hindawi.com)
  • Acinetobacter baumannii is a gram-negative aerobic bacillus that primarily causes hospital-acquired infections affecting specially to debilitated patients with prolonged hospitalization and with long-term exposition to antimicrobials. (medscape.com)
  • Adult Acinetobacter meningitis and its comparison with non-Acinetobacter gram-negative bacterial meningitis. (uptodate.com)
  • These organisms were the most frequently recovered gram-negative isolate from war wounds and the second most frequent bacterium causing bloodstream infection in US Marines with extremity wounds during the Vietnam War ( 3 ). (cdc.gov)
  • Acinetobacter bacteria are Gram-negative, aerobic, non-spore-forming bacteria that do not require complex media for growth ( 1 ). (asm.org)
  • Acinetobacter species are oxidase-negative, nonmotile, nonfermenting, short gram-negative bacilli that grow well at 37 ° C in aerobic conditions on a range of laboratory media (e.g., blood agar ). (mhmedical.com)
  • Acinetobacter Infection: Description, Causes and Risk Factors A genus of nonmotile, aerobic bacteria containing Gram negative or variable coccoid or short rods, or cocci, often occurring in pairs. (medigoo.com)
  • Treats infections caused by susceptible gram-negative and gram-positive organisms, in addition to infections caused by susceptible Chlamydia, Rickettsia, and Mycoplasma. (medscape.com)
  • Acinetobacter baumannii is a pleomorphic aerobic gram-negative bacillus (similar in appearance to Haemophilus influenzae on Gram stain) commonly isolated from the hospital environment and hospitalized patients. (medscape.com)
  • Acinetobacter baumannii is a highly ubiquitous Gram-negative bacterium, that is associated with significant disease in immunocompromised individuals. (edu.au)
  • Acinetobacter is a gram-negative coccobacillus separated from many human and environmental resources ( 9 ). (intjinfection.com)
  • Acinetobacter is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria. (wikipedia.org)
  • Species of the genus Acinetobacter are strictly aerobic, nonfermentative, Gram-negative bacilli. (wikipedia.org)
  • Acinetobacter soli is a Gram-negative, catalase-positive, oxidase-negative, strictly aerobic rod-shaped, nonmotile bacterium from the genus Acinetobacter isolated from forest soil at Mt. Baekwoon in the Republic of Korea. (wikipedia.org)
  • Selecting appropriate empiric and definitive antibacterial therapy for Acinetobacter is further complicated by the lack of reliability in commercial antimicrobial susceptibility testing devices and limited breakpoint interpretations for available agents. (springer.com)
  • A national alert was triggered in September 2003 when 4 hospitals reported clusters of A. baumannii infection with similar susceptibility profiles. (uptodate.com)
  • Clonally related strains of Acinetobacter that differ in susceptibility patterns may coexist within a single hospital, dependent on the selective pressure related to antibiotic exposure. (cambridge.org)
  • Antimicrobial Susceptibility Testing Methods for Acinetobacter spp. (apress.com)
  • Rather than being a single type of bacterium Acinetobacter is made up of over 25 varieties. (brighthub.com)
  • Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. (medscape.com)
  • A premature baby died while four others were found sick at a New Jersey hospital because of a bacterial infection. (inquisitr.com)
  • According to reports, health officials are probing into bacterial infections in the neonatal intensive care unit of University Hospital in Newark following the death of the premature baby in late September. (inquisitr.com)
  • The infant contracted the bacterial infection but the exact cause of death is still under investigation due to compounding medical conditions. (inquisitr.com)
  • Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A . mBio, Vol. 9, Issue. (cambridge.org)
  • Interestingly, this effective cocktail is composed of four phages that do not kill the parent strain of the infection and one phage that simply delays bacterial growth in vitro via a strong but incomplete selection event. (asm.org)
  • Acinetobacter baumannii is a bacterial species that can survive on moist and dry surfaces. (biomedcentral.com)
  • Other signs of this bad bacterial infection are redness around a wound and the presence of pus. (brighthub.com)
  • Results of this study suggest that the extract alone of Peganum harmala and Heracleum persicum may be useful to treat bacterial infections. (intjinfection.com)
  • including A. baumannii from vegetables: implications for hospital-acquired infections. (ajtmh.org)
  • Moreover, the blp1 gene is required for the establishing of A. baumannii virulence phenotype in nematode and murine infection models. (springer.com)
  • Acinetobacter species have low virulence but are capable of causing infection in organ transplants and febrile neutropenia. (medscape.com)
  • A. baumannii is a major cause of nosocomial infections affecting mainly to debilitating patients in the ICU, although the spread to regular wards and to long-term care facilities is increasing. (medscape.com)
  • Acinetobacter baumannii is gaining importance as a cause of nosocomial infections, but its role in skin and soft tissue infection (SSTI) is not well defined. (dalmatien.info)
  • Prolonged hospitalization or antibiotic therapy predisposes to Acinetobacter colonization. (medscape.com)
  • incident CRAB was a patient's first CRAB infection or colonization. (cdc.gov)
  • Diagnoses of CRAB infection or colonization were determined by infectious disease specialists. (cdc.gov)
  • Further, the study found that patients with a recent history of MDR-AB colonization or infection were not significantly more likely than those with a remote history of MDR-AB to contaminate their environment. (infectioncontroltoday.com)
  • The authors note several potential limitations including small sample size, lack of a comparison group, and the inability to determine which came first: environmental contamination or patient colonization/infection. (infectioncontroltoday.com)
  • In general, first-, second-, and third-generation cephalosporins, macrolides, and penicillins have little or no anti- Acinetobacter activity, and their use may predispose to Acinetobacter colonization. (medscape.com)
  • Care must be exercised in determining whether the isolate is due to colonization or is truly causing infection. (medscape.com)
  • Acinetobacter species are can be transmitted to patients because of their persistence on environmental surfaces and because of colonization of the hands of healthcare workers. (medscape.com)
  • Patients with Acb infection had more severe burns and comorbidities, and had longer lengths of stay compared with patients without Acb or those with Acb colonization. (elsevier.com)
  • Neurosurgically related nosocomial Acinetobacter baumannii meningitis: report of two cases and literature review. (medscape.com)
  • Meningitis is an infection of the brain or medulla spinals. (soundhealthsolution.com)
  • Tigecycline can be considered as an alternative therapy in patients with HAP or infections caused by Acinetobacter spp. (nih.gov)
  • However, such infections are increasingly being reported in patients admitted to conventional medical and surgical wards. (medindia.net)
  • Patients could be at a risk of contracting hospital infections due to the use of single dose vaccines or vials in two or more patients. (medindia.net)
  • Every year nearly 100,000 hospitalized patients die from infections acquired while undergoing treatment for other conditions, reports Centers for Disease Control and Prevention. (medindia.net)
  • In the United States, healthcare-associated infections kill 75,000 patients per year, say authorities. (medindia.net)
  • Patients who are immunosuppressed, have diabetes, or who are hospitalized (especially in intensive care units) are at increased risk for this infection. (visualdx.com)
  • On May 28, 2020, a New Jersey hospital (hospital A) reported a cluster of CRAB infections during a surge in patients hospitalized with coronavirus disease 2019 (COVID-19). (cdc.gov)
  • In addition, the study did not evaluate healthcare worker or patient movement and therefore cannot demonstrate transmission of Acinetobacter baumannii to patients as a result of environmental contamination. (infectioncontroltoday.com)
  • The researchers report that 560 community dwelling (mean age ± standard deviation, 74 ± 8.6 years) and 280 nursing home-dwelling (78 ± 9.1 years) patients had Acinetobacter isolated. (infectioncontroltoday.com)
  • Patients were followed up to 23 months after completing therapy, and none had recurrent infection with Acinetobacter species. (cdc.gov)
  • Previous studies have reported the isolation of Acinetobacter baumannii from the body lice of homeless patients. (ajtmh.org)
  • P. aeruginosa can be identified in a range of infections, especially those with a tendency to become chronic such as lung infections in cystic fibrosis patients (Wagner and Iglewski, 2008). (scielo.br)
  • Acinetobacter baumannii causes severe infections that primarily affect intensive care unit (ICU) patients. (jidc.org)
  • A. baumannii infections have been diagnosed in patients on all inhabited continents. (mhmedical.com)
  • The vast majority of infections occur in hospitalized patients and other patients with significant health care contact. (mhmedical.com)
  • 102 patients had bloodstream infections at facilities treating U.S. military personnel injured in Iraq or Afghanistan from January 1, 2002, through August 31, 2004. (mhmedical.com)
  • The infections developed by hospital patients tend to be the most problematic. (brighthub.com)
  • Staff that come into contact with patients infected with Acinetobacter bacteria are encouraged to wear gloves and gowns to reduce the risk of spreading the infection. (brighthub.com)
  • Although most A. baumannii infections occur in critically ill patients in the intensive care unit setting, the frequency of community-acquired A. baumannii infections has been increasing gradually. (dalmatien.info)
  • Outbreaks of Acinetobacter infections typically occur in intensive care units and healthcare settings housing very ill patients. (bscnnursesolomonmpanga.com)
  • Acinetobacter infection typically occurs in ill patients and can either cause or contribute to death in these patients. (bscnnursesolomonmpanga.com)
  • While there are many types or "species" of Acinetobacter and all can cause human disease, Acinetobacter baumannii accounts for about 80% of reported infections.Outbreaks of Acinetobacter infections typically occur in intensive care units and healthcare settings housing very ill patients. (medigoo.com)
  • Acinetobacter commonly colonizes patients in the intensive care setting. (medscape.com)
  • Acinetobacter infections are uncommon and occur almost exclusively in hospitalized patients. (medscape.com)
  • A retrospective review was conducted of the medical records of 29 sequential patients who received tigecycline for treatment of Acinetobacter infections. (blogspot.com)
  • The relationship between opportunistic pulmonary fungal infections and CD4 count levels among HIV-seropositive patients in Calabar, Nigeria. (blogspot.com)
  • Presently, MDR A. baumannii may be a serious health concern in hospitals and long-term care facilities accounting for up to 20% of infections in intensive care units, and 7% of infections in patients who are physically connected to medical equipments. (ekb.eg)
  • Fifty-nine patients met the case definition for infection. (elsevier.com)
  • Acinetobacter infection is associated with acquired glucose intolerance in burn patients. (ox.ac.uk)
  • Patients with Acinetobacter spp. (ox.ac.uk)
  • 001). In patients with deep Acinetobacter spp. (ox.ac.uk)
  • In patients with pre-existing diabetes mellitus, 27% developed Acinetobacter spp. (ox.ac.uk)
  • infection compared with only 8.5% of patients without diabetes (P = .04). (ox.ac.uk)
  • infection and glucose intolerance in burns patients. (ox.ac.uk)
  • Twelve patients grew Acinetobacter spp. (aku.edu)
  • In our study , which was published in the recent ICHE special edition , we found when patients are exposed to rooms contaminated with Acinetobacter baumannii they have an increased risk of acquiring this organism during their index admission. (reflectionsipc.com)
  • A retrospective, matched cohort investigation was performed at 2 Baltimore hospitals to examine outcomes of patients with MDR Acinetobacter infection compared with patients with susceptible Acinetobacter infections and patients without Acinetobacter infections. (elsevier.com)
  • During the follow-up period, all patients older than 18 years who developed NIs caused by Acinetobacter spp . (balkanmedicaljournal.org)
  • Acinetobacter species are a key source of infection in debilitated patients in the hospital, in particular the species Acinetobacter baumannii. (wikipedia.org)
  • The Food and Drug Administration (FDA) is announcing this public workshop regarding the current state and further development of animal models for serious infections caused by Acinetobacter baumanii and Pseudomonas aeruginosa . (fda.gov)
  • VEB-1 extended-spectrum beta-lactamase-producing Acinetobacter baumannii was responsible for an outbreak in hospitals in France. (uptodate.com)
  • Many civilian doctors say that the risk from returning troops isn't the main concern at this point, because acinetobacter is already rampant in U.S. hospitals. (pbs.org)
  • In contrast, most civilian hospitals do not share information, compliance standards or strategies for combating acinetobacter. (pbs.org)
  • In smaller, city hospitals like Nashville General, outbreaks of acinetobacter can cripple the ICU. (pbs.org)
  • As hard as it is to kill as acinobacter, most doctors agree that the easiest way to prevent infections is stricter hygiene compliance and limiting antibiotic exposure, both in military and civilian hospitals. (pbs.org)
  • Ensuring that hospital staff comply with infection control tactics and thoroughly clean equipment and surfaces to eradicate the bacteria requires time and money that many hospitals don't have. (pbs.org)
  • Treatment of Acinetobacter infections. (medscape.com)
  • Data from more studies are needed before tigecycline can be recommended for the treatment of Acinetobacter infections. (blogspot.com)
  • In September 2012 , in collaboration with Intrexon, we initiated efforts to develop a mAb therapy for the treatment of Acinetobacter infections. (prnewswire.com)
  • Bloodstream infection due to Acinetobacter baumannii is characterized as a nosocomial infection, particularly occurs in intensive care units (ICUs). (jjmicrobiol.com)
  • Outbreaks of Acinetobacter infections, often caused by multiresistant strains, have been widely reported, commonly in intensive care units (ICUs) in North America and Europe. (asm.org)
  • with healthcare associated infections (HCAI) in intensive care units (ICU) is alarming. (hindawi.com)
  • Zhu W, Wang Y, Cao W, Zhang J. A Case Report of Persistent Acinetobacter baumannii Bloodstream Infection, Jundishapur J Microbiol. (jjmicrobiol.com)
  • Our findings shed light on the treatment of persistent bloodstream infection due to A. baumannii . (jjmicrobiol.com)
  • Bloodstream infection due to Acinetobacter baumannii is characteristically a nosocomial infection with a fatality rate of up to 37% ( 1 ). (jjmicrobiol.com)
  • This report systematically describes the course of persistent bloodstream infection and provides some information regarding the treatment of A. baumannii . (jjmicrobiol.com)
  • An outbreak of bloodstream infection due. (erciyes.edu.tr)
  • Acinetobacter soli can cause bloodstream infection in neonates. (wikipedia.org)
  • Acinetobacter species are oxidase-negative, exhibit twitching motility, and occur in pairs under magnification. (wikipedia.org)
  • Representatives (n = 31) of outbreak strains of Acinetobacter baumannii from five countries fell into three clear groups, designated Groups 1-3, based on their ompA (outer-membrane protein A), csuE (part of a pilus assembly system required for biofilm formation) and bla(OXA-51-like) (the intrinsic carbapenemase gene in A. baumannii) gene sequences. (nih.gov)
  • Acinetobacter infections: a retrospective study to determine in hospit" by Rajiv Patel, Jasmit Shah et al. (aku.edu)
  • There are no compelling data to recommend combination therapy for severe A. baumannii infections. (medscape.com)
  • which are often nosocomial in nature and can cause severe local and systemic infections ( 1 , 2 ). (asm.org)
  • They can also cause severe primary infections in immunocompromised people. (medigoo.com)
  • Results: Empirical coverage of A. baumannii is recommended in severe infections (severe sepsis or septic shock) occurring during an A. baumannii outbreak, in an endemic setting, or in a previously colonized patient. (elsevier.com)
  • Ecological aspects and prophylaxis of Acinetobacter baumannii nosocomial infection. (ajtmh.org)
  • The increasing emergence of Acinetobacter spp. (hindawi.com)
  • There has been recent emergence of Acinetobacter spp. (hindawi.com)
  • Importation of Acinetobacter baumannii into a burn unit: a recurrent outbreak of infection associated with widespread environmental contamination. (unil.ch)
  • Eighteen had osteomyelitis, 2 burn infection, and 3 deep wound infection. (cdc.gov)
  • Skin or wound infection: Any skin gap or wound will get infected with the germ. (soundhealthsolution.com)
  • Flow chart illustrating active-duty soldier admissions to Brooke Army Medical Center from March 1, 2003, to May 31, 2004, and those who met case definitions for Acinetobacter osteomyelitis or wound infection. (cdc.gov)
  • Pimenta oil as a potential treatment for Acinetobacter baumannii wound infection. (greenmedinfo.com)
  • In late March, increasing COVID-19-related hospitalizations led to shortages in personnel, personal protective equipment (PPE), and medical equipment, resulting in changes to conventional infection prevention and control (IPC) practices. (cdc.gov)
  • From an infection prevention perspective, the nature of Acinetobacter baumannii makes it an organism on the radar for prevention efforts against health care-associated infections. (dalmatien.info)
  • Utilizing our portfolio of beta-lactamase enzymes we acquired in November 2012 , we intend to develop a proprietary oral beta-lactamase enzyme product candidate, SYN-004 (formerly Ipsat P3A), for the prevention of C. difficile infections (CDI). (prnewswire.com)
  • No specific guidelines exist addressing the prevention and management of A. baumannii infections in the critical care setting. (elsevier.com)
  • Conclusions: Specific recommendations about prevention and management of A. baumannii infections in the ICU were elaborated by this multidisciplinary panel. (elsevier.com)