Acinetobacter baumannii: A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.Acinetobacter Infections: Infections with bacteria of the genus ACINETOBACTER.Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.Carbapenems: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.Acinetobacter calcoaceticus: A species of gram-negative, aerobic bacteria found in soil and water. Although considered to be normally nonpathogenic, this bacterium is a causative agent of nosocomial infections, particularly in debilitated individuals.Drug Resistance, Multiple, Bacterial: The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Colistin: Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Cross Infection: Any infection which a patient contracts in a health-care institution.beta-Lactamases: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.beta-Lactam Resistance: Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.Thienamycins: Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.Electrophoresis, Gel, Pulsed-Field: Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.Sulbactam: A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Bacterial Proteins: Proteins found in any species of bacterium.Molecular Typing: Using MOLECULAR BIOLOGY techniques, such as DNA SEQUENCE ANALYSIS; PULSED-FIELD GEL ELECTROPHORESIS; and DNA FINGERPRINTING, to identify, classify, and compare organisms and their subtypes.Intensive Care Units: Hospital units providing continuous surveillance and care to acutely ill patients.DNA Fingerprinting: A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Integrons: DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes.Multilocus Sequence Typing: Direct nucleotide sequencing of gene fragments from multiple housekeeping genes for the purpose of phylogenetic analysis, organism identification, and typing of species, strain, serovar, or other distinguishable phylogenetic level.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Molecular Epidemiology: The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.Hospitals: Institutions with an organized medical staff which provide medical care to patients.Gram-Negative Bacteria: Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.Disease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.Genes, Bacterial: The functional hereditary units of BACTERIA.Pneumonia, Bacterial: Inflammation of the lung parenchyma that is caused by bacterial infections.Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.beta-Lactams: Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Disk Diffusion Antimicrobial Tests: A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent.Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.Polymyxin B: A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.Monobactams: Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.Microbial Viability: Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.Polymyxins: Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.Pneumonia, Ventilator-Associated: Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by cross bacterial infections in hospitals (NOSOCOMIAL INFECTIONS).Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Equipment and Supplies, Hospital: Any materials used in providing care specifically in the hospital.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Biofilms: Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.Housekeeping, Hospital: Hospital department which manages and provides the required housekeeping functions in all areas of the hospital.DNA Transposable Elements: Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.Siderophores: Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Aminoglycosides: Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.Bacterial Outer Membrane Proteins: Proteins isolated from the outer membrane of Gram-negative bacteria.Hospitals, Military: Hospitals which provide care for the military personnel and usually for their dependents.Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)Genomic Islands: Distinct units in some bacterial, bacteriophage or plasmid GENOMES that are types of MOBILE GENETIC ELEMENTS. Encoded in them are a variety of fitness conferring genes, such as VIRULENCE FACTORS (in "pathogenicity islands or islets"), ANTIBIOTIC RESISTANCE genes, or genes required for SYMBIOSIS (in "symbiosis islands or islets"). They range in size from 10 - 500 kilobases, and their GC CONTENT and CODON usage differ from the rest of the genome. They typically contain an INTEGRASE gene, although in some cases this gene has been deleted resulting in "anchored genomic islands".Multiplex Polymerase Chain Reaction: Methods for using more than one primer set in a polymerase chain reaction to amplify more than one segment of the target DNA sequence in a single reaction.Burn Units: Specialized hospital facilities which provide intensive care for burn patients.Infection Control: Programs of disease surveillance, generally within health care facilities, designed to investigate, prevent, and control the spread of infections and their causative microorganisms.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.TaiwanDrug Resistance, Multiple: Simultaneous resistance to several structurally and functionally distinct drugs.Pediculus: Lice of the genus Pediculus, family Pediculidae. Pediculus humanus corporus is the human body louse and Pediculus humanus capitis is the human head louse.Bacterial Processes: The functions, behavior, and activities of bacteria.Hospitals, University: Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.Tertiary Care Centers: A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.Klebsiella pneumoniae: Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.IraqWound Infection: Invasion of the site of trauma by pathogenic microorganisms.Colony Count, Microbial: Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.Meningitis, Bacterial: Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.Czech Republic: Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.Random Amplified Polymorphic DNA Technique: Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.
Distribution of beta-lactamases in Acinetobacter baumannii clinical isolates and the effect of Syn 2190 (AmpC inhibitor) on the MICs of different beta-lactam antibiotics. (1/853)
The distribution of beta-lactamases in a group of 20 epidemiologically well defined Acinetobacter baumannii clinical isolates and the in vitro activity of Syn 2190, a novel beta-lactamase AmpC inhibitor, were determined. Twenty-five per cent of the strains carried and expressed a TEM-type beta-lactamase, whereas 35% had an OXA-type beta-lactamase. In nine out of 11 (82%) ceftazidime-resistant and four out of 13 (30.7%) cefepime-resistant strains, the MIC of these beta-lactam antibiotics decreased when determined in the presence of Syn 2190. Thus, our results suggest that in a high percentage of A. baumannii clinical isolates the increased production of AmpC, in combination or not with other resistance mechanisms, contributes to the resistance pattern in A. baumannii to beta-lactams. (+info)Molecular characterization of integrons in epidemiologically unrelated clinical isolates of Acinetobacter baumannii from Italian hospitals reveals a limited diversity of gene cassette arrays. (2/853)
Integron carriage by 36 epidemiologically unrelated Acinetobacter baumannii isolates collected over an 11-year period from patients in six different Italian hospitals was investigated. Sixteen type 1 integron-positive isolates (44%) were found, 13 of which carried the same array of cassettes, i.e., aacC1, orfX, orfX', and aadA1a. As ribotype analysis of the isolates demonstrated a notable genetic diversity, horizontal transfer of the entire integron structure or ancient acquisition was hypothesized. (+info)Genetic and phenotypic analysis of Acinetobacter baumannii insertion derivatives generated with a transposome system. (3/853)
Acinetobacter baumannii is a metabolically versatile pathogen that causes severe infections in compromised patients. However, little is known about the genes and factors involved in its basic physiology and virulence properties. Insertion mutagenesis was used to initiate the identification and characterization of some of these factors and genes in the prototype strain 19606. The utilization of the pLOFKm suicide delivery vector, which harbors a suicide mini-Tn10 derivative, proved to be unsuccessful for this purpose. The EZ::TNComparison of a repetitive extragenic palindromic sequence-based PCR method and clinical and microbiological methods for determining strain sources in cases of nosocomial Acinetobacter baumannii bacteremia. (4/853)
Using a repetitive extragenic palindromic PCR (REP-PCR), we genotypically characterized strains causing nosocomial Acinetobacter baumannii infections and analyzed the source of bacteremia in 67 patients from an institution in which infections by this bacterium were endemic. Six different genotypes were found, including 21, 27, 3, 9, 3, and 4 strains. The probable source of bacteremia, according to clinical and/or microbiological criteria, was known in 42 patients (63%): respiratory tract (n = 19), surgical sites (n = 12), intravascular catheters (n = 5), burns (n = 3), and urinary tract (n = 3). The definite source of bacteremia, according to REP-PCR, could be established in 30 (71%) out of the 42 patients with strains from blood and other sites; in these cases clinical and microbiological criteria for the source of bacteremia were thus confirmed. In the remaining 12 patients (29%) the probable source was refuted by the REP-PCR method. The definite sources of bacteremia according to genotype were as follows: respiratory tract in 13 patients (31%), surgical sites in 8 (19%), intravascular catheters in 4 (9%), burns in 3 (7%), and urinary tract in 2 (5%). A comparison of strains from blood cultures and other sites with regard to their REP-PCR and antimicrobial resistance profiles was also made. Taking the REP-PCR as the "gold standard," the positive predictive value of antibiotype was 77% and the negative predictive value was 42%. In summary, the utility of the diagnosis of the source of nosocomial A. baumannii bacteremia using clinical and/or microbiological criteria, including antibiotyping, is limited, as demonstrated by REP-PCR. (+info)Endemic carbapenem resistance associated with OXA-40 carbapenemase among Acinetobacter baumannii isolates from a hospital in northern Spain. (5/853)
Eighty-two carbapenem-resistant isolates of Acinetobacter baumannii from a single hospital in Bilbao were typed into two major clusters and several subclusters. Disk synergy tests and PCR indicated the production of a zinc-independent OXA-class carbapenemase. Sequencing identified this enzyme, OXA-40, as a variant of the OXA-24-OXA-25-OXA-26 cluster. (+info)Loss of a 29-kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance. (6/853)
We analyzed the possible causes of imipenem (IPM) resistance in multidrug-resistant isolates of Acinetobacter baumannii. Comparison of the outer membrane protein (OMP) profiles of two genomically related strains (Ab288 [IPM sensitive] and Ab242 [IPM resistant]) indicated the conspicuous loss of a 29-kDa polypeptide in the Ab242 strain. No carbapenemase activity was detected in any of these strains. The treatment of Ab288 with sodium salicylate resulted in IPM resistance and the loss of the 29-kDa OMP. In addition, IPM-resistant clones of Ab288 which were selected by repetitive culturing in increasing concentrations of this antibiotic also showed the absence of this 29-kDa OMP. (+info)Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii. (7/853)
Clinical isolate Acinetobacter baumannii CLA-1 was resistant to a series of antibiotic molecules, including carbapenems. Cloning and expression of the beta-lactamase gene content of this isolate in Escherichia coli DH10B identified a chromosome-encoded oxacillinase, OXA-40, that differed by one or two amino acid changes from OXA-24, -25, and -26 and an AmpC-type cephalosporinase. The OXA-40 beta-lactamase had a mainly narrow-spectrum hydrolytic profile, but it included ceftazidime and imipenem. Its activity was resistant to inhibition by clavulanic acid, tazobactam, sulbactam, and, like most of the other carbapenem-hydrolyzing oxacillinases, NaCl. OXA-40 had an FGN triad replacing a YGN motif at class D beta-lactamase (DBL) positions 144 to 146. Site-directed DNA mutagenesis leading to a Phe-to-Tyr change at DBL position 144 in OXA-40 gave a mutant enzyme with increased hydrolytic activity against most beta-lactams, including imipenem. Conversely, with a gene encoding the narrow-spectrum oxacillinase OXA-1 as the template, a nucleotide substitution leading to a Tyr-to-Phe change in the YGN motif of OXA-1 gave a mutant enzyme with decreased hydrolytic activity without an increase in carbapenem-hydrolyzing activity. Thus, the Phe residue in the FGN motif was not associated with carbapenem-hydrolyzing activity by itself but instead was associated with weak overall hydrolytic activity. Finally, this Phe residue in OXA-40 explained resistance to inhibition by NaCl whereas a Tyr residue in motif YGN was related to susceptibility to NaCl. (+info)Relationship between beta-lactamase production, outer membrane protein and penicillin-binding protein profiles on the activity of carbapenems against clinical isolates of Acinetobacter baumannii. (8/853)
Twenty blood isolates of Acinetobacter baumannii were studied, representing eight pulsed-field gel electrophoresis patterns and all different antimicrobial susceptibility patterns observed during 1995-97 at the University Hospital Virgen Macarena, Seville, Spain. The MIC(90)s (mg/L) of imipenem and meropenem decreased from 16 to 0.5 and from 8 to 4, respectively, in the presence of BRL 42715 (BRL) but not clavulanic acid. Hydrolysing activity (nmol/min/mg) of bacterial supernatants against cefaloridine ranged from 8.8 to 552.3 for A. baumannii type I (imipenem MICs < or = 2), which expressed only a beta-lactamase of pI > or = 9, and from 12.3 to 1543.5 for A. baumannii type II (imipenem MICs > or = 4), which expressed a beta-lactamase of pI > or = 9 and two others of pI 6.3 and 7. The hydrolysing activities of A. baumannii type II against imipenem, meropenem and oxacillin were higher than those observed for A. baumannii type I. Ten outer membrane protein (OMP) profiles (A. baumannii types I and II) were visualized on 10% SDS-PAGE gels with 6 M urea, whereas only five OMP profiles (A. baumannii types I and II) were differentiated in 12% SDS-PAGE gels. Five A. baumannii with OMP profile type B, characterized by the absence of a 22.5 kDa OMP, were resistant to meropenem and/or imipenem. Twelve penicillin-binding protein (PBP) patterns were observed. PBP patterns of A. baumannii type II were characterized by the absence of a 73.2 kDa band (PBP 2). We concluded that production of beta-lactamases of pI 6.3 and 7.0 and reduced expression of PBP 2 are the most frequently observed mechanisms of resistance to carbapenems. In some isolates, loss of a 22.5 kDa OMP is also related to resistance to carbapenems. (+info)Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ...
Used to treat XDR Acinetobacter baumannii infections. Tolcapone - used in patients with Parkinson's disease who are not ...
"Deciphering the Multifactorial Nature of Acinetobacter baumannii Pathogenicity". PLoS ONE. 6 (8): e22674. doi:10.1371/journal. ...
It also demonstrates potent in vitro activity versus carbapenem-resistant Acinetobacter baumannii. In 2012, U.S. Food and Drug ... "Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant Acinetobacter baumannii?" (PDF). ...
"Medscape abstract on Acinetobacter baumannii: Acinetobacter baumannii: An Emerging Multidrug-resistant Threat". membership only ... Centers for Disease Control Prevention (CDC). (2004). "Acinetobacter baumannii infections among patients at military medical ... reported an increasing number of Acinetobacter baumannii bloodstream infections in patients at military medical facilities in ... Acinetobacter is a gram-negative bacteria that causes pneumonia or bloodstream infections in critically ill patients. Multidrug ...
Use of colistin to treat Acinetobacter baumannii infections has led to the development of resistant bacterial strains. which ... Colistimethate sodium has also been given intrathecally and intraventricularly in Acinetobacter baumannii and Pseudomonas ... Towner K J (2008). "Molecular Basis of Antibiotic Resistance in Acinetobacter spp.". Acinetobacter Molecular Biology. www. ... "In-vitro activity of the combination of colistin and rifampicin against multidrug-resistant strains of Acinetobacter baumannii ...
Successful Treatment of Multidrug-Resistant Acinetobacter baumannii Ventriculitis with Intravenous and Intraventricular ...
IV phage drip therapy was successfully used to treat a patient with MDR Acinetobacter baumannii in Thornton Hospital at UC San ... "Bacteriophage therapy treats patient near death with MDR Acinetobacter baumannii - Outbreak News Today". 25 April 2017. Keen, E ...
"Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii." ...
"Isolation and Characterization of Antimicrobial Compounds in Plant Extracts against Multidrug-Resistant Acinetobacter baumannii ...
"Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from ... Non-lactose fermenting Gram-negative bacteria Acinetobacter baumannii Stenotrophomonas maltophilia Haemophilus influenzae ...
"Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and ... It lacks useful activity against the P. aeruginosa and Acinetobacter species, both of which are important causes of hospital- ... Antibiotics cross the outer membrane of Pseudomonas and Acinetobacter approximately 100 times more slowly than they cross the ... Infections caused by the non-fermenting gram-negative bacteria Pseudomonas aeruginosa and Acinetobacter baumanni are most ...
In July 2010, a team in New Delhi reported a cluster of three cases of Acinetobacter baumannii bearing blaNDM-1 that were found ... "Coexistence of blaOXA-23 with blaNDM-1 and armA in clinical isolates of Acinetobacter baumannii from India". J Antimicrob ... The patient was also found to be carrying an Acinetobacter strain. The patient contracted the bacteria after another patient, ...
... outbreaknewstoday.com/bacteriophage-therapy-treats-patient-near-death-mdr-acinetobacter-baumannii-45488/ Wommack, K. E.; ...
2011). "Whole-genome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed ... 2014). "Genomic epidemiology of a protracted hospital outbreak caused by multidrug-resistant Acinetobacter baumannii in ...
2005). "Ethanol-induced virulence of Acinetobacter baumannii". American Society for Microbiology meeting. Volume 1 June 5 - ...
... and Acinetobacter baumannii". Int. J. Antimicrob. Agents. 34 (5): 395-401. doi:10.1016/j.ijantimicag.2009.06.021. PMID 19665876 ... It may be used to treat certain strains of MRSA infection and a disease caused by drug resistant Acinetobacter. Both ...
4-diaminobutyrate decarboxylase of Acinetobacter baumannii". FEMS Microbiol. Lett. 124 (2): 225-8. doi:10.1111/j.1574-6968.1994 ... 3-diaminopropane production pathway in Acinetobacter baumannii". J. Bacteriol. 179 (16): 5118-25. PMC 179370 . PMID 9260954. ... 4-diaminobutyrate decarboxylase from Acinetobacter calcoaceticus". J. Gen. Microbiol. 138 (7): 1461-5. doi:10.1099/00221287-138 ...
Acinetobacter baumannii was isolated from a patient in a burn unit and two clinical strains of MTB were collected and tested. ... Acinetobacter baumanii, Enterococcus spp., and Candida albicans on the copper alloy surfaces versus the non-copper standard ...
Acinetobacterസംക്രമണം Acinetobacter baumannii ആക്റ്റിനോ മൈക്കോസിസ് Actinomyces israelii, Actinomyces gerencseriae and ...
Acinetobacter baumannii, and E. coli. As a tetracycline derivative antibiotic, its structural modifications has expanded its ... and multi-drug resistant strains of Acinetobacter baumannii. It has no activity against Pseudomonas spp. or Proteus spp. The ...
... associated with hospital-acquired infections include Acinetobacter baumannii, which cause bacteremia, ... It has also been studied in gram-negative species found in soil such as Pseudomonas stutzeri, Acinetobacter baylyi, and gram- ...
3-diaminopropane production pathway in Acinetobacter baumannii". J. Bacteriol. 179 (16): 5118-25. PMC 179370 . PMID 9260954. ...
MDR strains of Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii have become of most concern because they ... Acinetobacter baumannii, Klebsiella pneumoniae and Stenotrophomonas maltophilia. Also, there has been interest in the drug ...
... while Acinetobacter baumannii, some Acinetobacter spp., Bacteroides fragilis, and Enterococcus faecalis have developed ... Acinetobacter anitratus, Acinetobacter calcoaceticus, Actinomyces odontolyticus, Aeromonas hydrophila, Bacteroides distasonis, ...
Acinetobacter baumannii. Xanthomonadaceae. *Stenotrophomonas maltophilia. Cardiobacteriaceae. *Cardiobacterium hominis *HACEK. ...
The antibiotic susceptibility of Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains recovered from the ... Outbreak of imipenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex harboring different carbapenemase ... Spread of imipenem-resistant Acinetobacter baumannii of European clone II in Western China. Chao He, Yi Xie, Hong Fan, Mei Kang ... Dissemination of imipenem-resistant Acinetobacter baumannii strains carrying the ISAba1 blaOXA-23 genes in a Chinese hospital. ...
Lastly, the presence of Acinetobacter baumannii DNA was demonstrated by qPCR and sequencing in four head lice remains belonging ...
... baumannii is commonly involved in nosocomial infections, but few therapeutic options are available. Find out what there is to ... Acinetobacter baumannii is one of the most frequently isolated bacteria in the ICU but significant regional differences exist. ... Acinetobacter baumannii is a gram-negative aerobic bacillus that primarily causes hospital-acquired infections affecting ... Purpose of review: We reviewed recent data about epidemiology of Acinetobacter baumannii, resistance mechanisms, and ...
ECDC highlights need for increased efforts to prevent carbapenem-resistant A. baumannii outbreaks Acinetobacter baumannii is ...
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... Designation: S2 TypeStrain=False Application: Assay of cefoperazone Assay of sulbactam ... Acinetobacter baumannii (ATCC® 43498™) Strain Designations: S2 / Type Strain: no / Biosafety Level: 2 ...
Each antibiotic is presented in three columns. The first column lists the name of the antibiotic. The middle column represents susceptibility in percent to that antibiotic. The 3rd column represents the number of isolates tested for that specific antibiotic ...
Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis.. Jacobs AC1, Hood I, Boyd KL, Olson PD, ... Acinetobacter baumannii is an emerging bacterial pathogen of considerable health care concern. Nonetheless, relatively little ... B) Chromosomal organization of A. baumannii strain ATCC 17978 locus A1S_2989 with the strain ACJ2 transposon EZ-Tn5 ,R6Kγori/ ... Plotted are the numbers of CFU ml of A. baumannii−1 internalized following 4 h of incubation. (B) Internalization properties of ...
Genomic DNA from Acinetobacter baumannii strain AYE (ATCC ® BAA-1710™) TypeStrain=False Application: ... Acinetobacter baumannii (ATCC® BAA-1710D-5™) Strain Designations: Genomic DNA from Acinetobacter baumannii strain AYE (ATCC® ... Acinetobacter baumannii plasmid p2ABAYE, complete sequence Nucleotide (GenBank) : NC_010410 Acinetobacter baumannii AYE, ... Acinetobacter baumannii ATCC® BAA-1710D-5™ freeze-dried Total DNA: At least 5 µg in 1X TE buffer. OD260/OD280: 1.6 to 2.0 ...
Objectives: The objectives of this study were to study the presence of mutators in a set of Acinetobacter baumannii isolates ... Prevalence of hypermutators among clinical Acinetobacter baumannii isolates. Komp Lindgren, Patricia Uppsala University, ... Methods: The variation in mutation rate was evaluated for 237 clinical A. baumannii isolates by determining the frequency of ...
Genomic DNA from Acinetobacter baumannii strain 2208 TypeStrain=True Application: Food testing ... Acinetobacter baumannii Bouvet and Grimont (ATCC® 19606D-5™) Strain Designations: Genomic DNA from Acinetobacter baumannii ... Acinetobacter baumannii Bouvet and Grimont ATCC® 19606D-5™ dried At least 5 µg in 1X TE buffer ... Nucleotide (GenBank) : AF100557 Acinetobacter baumannii DNA gyrase A (gyrA) gene, partial cds. ...
A. baumannii is an opportunistic infection that commonly "enters" through a vent, open wound (usually dressed/covered in ... acinetobacter baumannii epidemic in Maryland hospital. page: 1 #liveFeed1, #liveFeed2, #liveFeed3 { margin: 40px 2px 50px 4px; ...
This topic contains 2 study abstracts on Acinetobacter baumannii infection indicating that the following substances may be ... 1 Abstracts with Acinetobacter baumannii infection & Raspberry root Research. [x] Remove Focus on Raspberry root. Filter by ... Diseases : Anthrax, Bacillus anthracis, Carbapenem-resistant Acinetobacter baumannii (CRAB), MRSA. Pharmacological Actions : ... 1 Problem Substances Researched for Acinetobacter baumannii infection Name. AC. CK. Focus. ...
Carbapenem-resistant Acinetobacter baumannii (CRAB)Anti-Tumor,Tumors,Iodine,Lectin-Induced Cancer,Vegetables: All,Thyroid ... Carbapenem-resistant Acinetobacter baumannii (CRAB) is a Sub of the following Topics. *Acinetobacter baumannii infection ... Carbapenem-resistant Acinetobacter baumannii (CRAB) Related Articles. Could Turmeric Save Us From The CDCs Nightmare Bacteria ... 1 Abstracts with Carbapenem-resistant Acinetobacter baumannii (CRAB) Research. Filter by Study Type. In Vitro Study. ...
Background We describe the prevalence of invasive carbapenem-resistant Acinetobacter spp. isolated from 2005 to 2016 in ... Genotypic and phenotypic characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal ... formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Acinetobacter genomic species 13TU ... which belong to the so-called Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex. Generally, these four species ...
3ZPG: Structure of Diaminohydroxyphosphoribosylaminopyrimidine Deaminase/5-Amino-6-(5-Phosphoribosylamino)Uracil Reductase from Acinetobacter Baumannii.
T. D. Gootz and A. Marra, "Acinetobacter baumannii: an emerging multidrug-resistant threat," Expert Review of Anti-Infective ... B. A. Eijkelkamp, K. A. Hassan, I. T. Paulsen, and M. H. Brown, "Investigation of the human pathogen Acinetobacter baumannii ... Cloning, Expression, and Purification of Nucleoside Diphosphate Kinase from Acinetobacter baumannii. Juhi Sikarwar, Sanket ... A. Howard, M. ODonoghue, A. Feeney, and R. D. Sleator, "Acinetobacter baumannii: an emerging opportunistic pathogen," ...
... industrial applications and more information for Acinetobacter baumannii. ... Acinetobacter baumannii is an opportunistic pathogen and is a problem in the hospital setting in US and Europe. Many strains ... Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter. Industrial uses or economic ...
KEGG Orthology (KO) - Acinetobacter baumannii AYE [ Brite menu , Organism menu , Download htext , Download json ] ...
... E. ... "Mutant Prevention Concentrations of Imipenem and Meropenem against Pseudomonas aeruginosa and Acinetobacter baumannii," The ...
... Michal Jarmoluk / Pixabay ... Acinetobacter baumannii bacteria is known to cause pneumonia or serious blood or wound infections. ... Following the childs death, the state Department of Health also discovered four cases of Acinetobacter baumannii infection in ... Wade said that acinetobacter is a hospital-acquired infection with no community transmission, which means that it does not pose ...
In laboratory experiments, we compared the abilities of five Acinetobacter baumannii strains, three Acinetobacter sp. strains ... Survival of Acinetobacter baumannii on dry surfaces. Message Subject (Your Name) has forwarded a page to you from Journal of ... Survival of Acinetobacter baumannii on dry surfaces.. C Wendt, B Dietze, E Dietz, H Rüden ... Acinetobacter spp. have frequently been reported to be the causative agents of hospital outbreaks. The circumstances of some ...
Inhaled colistin on Acinetobacter baumannii treatment. Gustavo Coimbra dos Reis, Ana Martins, Luís Bento ... Inhaled colistin on Acinetobacter baumannii treatment Message Subject (Your Name) has sent you a message from European ... A. baumannii was extensively resistant in all cases, being sensible only to polymyxins in 20 (87%). Mean inhaled colistin diary ... Conclusions: On critical patients, inhaled colistin was effective treating PAV/TAV due to extensively resistant A. baumannii. ...
KEGG Orthology (KO) - Acinetobacter baumannii MDR-TJ [ Brite menu , Organism menu , Download htext , Download json ] ...
Multidrug-resistant AcinetobacterCalcoaceticusResistanceGenesResistantRRNAIsolatesAbstractPathogenATCCMulti-drug resiColistinAntibioticsCarbapenem-resistant AcinetobacterSusceptibilityPrevalenceSpeciesMultidrug resistant Acinetobacter baumannii isolatedMortalityStrainBacterialMotilityNosocomial infectionsInfections Caused by AcinetobacterPseudomonas aeruginosa and AcinetobacterDeterminantsMethodsTherapeuticBiofilm formationEpidemic Acinetobacter baumanniiPneumoniaImipenemGenomicGenomeEndemicGeneAerobicMechanismsEmergenceBacteremiaIntensiveEfflux pumpResistance to antimicrobial agentsCharacterizationPlasmidIsolats d'Acinetobacter baumannii
- Sequential outbreaks of multidrug-resistant Acinetobacter baumannii in intensive care units of a tertiary referral hospital in Italy: combined molecular approach for epidemiological investigation. (qxmd.com)
- Dissemination of multidrug resistant Acinetobacter baumannii in various hospitals of Antananarivo Madagascar. (qxmd.com)
- Susceptibility patterns and molecular epidemiology of multidrug-resistant Acinetobacter baumannii strains from three military hospitals in China. (qxmd.com)
- The antibiotic susceptibility of Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains recovered from the intensive care unit (ICU) of West China Hospital, Sichuan, PR China, from 2006 to 2009 was investigated. (qxmd.com)
- The results showed that the antibiotic susceptibility of the A. calcoaceticus-A. baumannii complex isolates changed and imipenem resistance increased rapidly between 2006 and 2009. (qxmd.com)
- Outbreak of imipenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex harboring different carbapenemase gene-associated genetic structures in an intensive care unit. (qxmd.com)
- These findings indicate a situation of increasing resistance and wide distribution of class D β-lactamase genes, especially the acquired ISAba1-associated blaOXA-23 gene, in A. baumannii isolates in the ICU of West China Hospital, probably caused by expansion of the CC92 clone. (qxmd.com)
- The identification of A. baumannii and analysis of carbapenemase-encoding genes and their relationship with ISAba1 were performed by PCR. (qxmd.com)
- The blaOXA-51-like and ISAba1-associated blaOXA-23 genes were prevalent in the imipenem-resistant A. baumannii isolates. (qxmd.com)
- Dissemination of imipenem-resistant Acinetobacter baumannii strains carrying the ISAba1 blaOXA-23 genes in a Chinese hospital. (qxmd.com)
- The representative multidrug-resistant A. baumannii isolates were identified as one cluster by rep-PCR fingerprinting and belonged to the clonal complex 92 (CC92) according to MLST. (qxmd.com)
- Spread of imipenem-resistant Acinetobacter baumannii of European clone II in Western China. (qxmd.com)
- Molecular characteristics and resistant mechanisms of imipenem-resistant Acinetobacter baumannii isolates in Shenyang, China. (qxmd.com)
- Clusters of imipenem-resistant Acinetobacter baumannii clones producing different carbapenemases in an intensive care unit. (qxmd.com)
- To identify virulence factors that may contribute to these disease processes, genetically diverse A. baumannii clinical isolates were evaluated for the ability to proliferate in human serum. (nih.gov)
- All clinical isolates were confirmed to be A. baumannii by Microscan Identification Panel assessment (data not shown) and were subjected to PFGE to assess their clonality. (nih.gov)
- The objectives of this study were to study the presence of mutators in a set of Acinetobacter baumannii isolates and to explore whether there is a correlation between mutation rates and antibiotic resistance. (diva-portal.org)
- The variation in mutation rate was evaluated for 237 clinical A. baumannii isolates by determining the frequency of their mutation to rifampicin resistance. (diva-portal.org)
- Despite a relatively stable number of carbapenem-resistant Acinetobacter isolates in Switzerland, our results suggest the existence of a diverse pool of A. baumannii species in hospital settings, and confirm the implication of carbapenem-resistant Acinetobacter calcoaceticus - Acinetobacter baumannii (ACB) complex in the vast majority of clinical infections and nosocomial outbreaks with notable regional fluctuations. (springer.com)
- The characteristics of carbapenem heteroresistance were studied in 14 apparently carbapenem-susceptible Acinetobacter baumannii isolates. (asm.org)
- However, reduced susceptibility or resistance to carbapenems is increasingly being observed among A. baumannii clinical isolates ( 2 , 5 , 25 ). (asm.org)
- Likewise, a recent study ( 12 ) has described colistin-heteroresistant subpopulations among apparently colistin-susceptible A. baumannii clinical isolates, implying an intrinsic potential of the species to overcome drug pressure. (asm.org)
- The present study aimed to evaluate in vitro the incidence of carbapenem heteroresistance, to characterize the traits of the heteroresistant subpopulations, and to assess the efficacies of carbapenems against heteroresistant A. baumannii isolates. (asm.org)
- All single A. baumannii clinical isolates that were recovered in the University Hospital of Larissa (Larissa, Greece), a tertiary-care hospital with 700 beds, over a 6-month period from September 2007 to March 2008 were recorded. (asm.org)
- Two MDR A. baumannii isolates (ATCC 17978 and AB 251847) were separately cultured in tryptic soy broth (∼6 log CFU/ml) containing the minimum inhibitory concentration (MIC) of TC or EG with or without the MIC of each antibiotic at 37°C for 18 h. (frontiersin.org)
- The aim of the present study is to assess the prevalence of extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases among isolates of A. baumannii collected from different clinical sources in Mansoura University Hospitals, Egypt. (springer.com)
- The study demonstrates high prevalence of resistance to β-lactam antibiotics through ESBLs and AmpC β-lactamases production among A. baumannii clinical isolates. (springer.com)
- The genetic basis of antimicrobial resistance in Bolivia has not been deeply studied until now, and the mobilome of these A. baumannii isolates, combined with their multi-drug resistant phenotype, mirror the transfer and prevalence of MGEs contributing to the spread of antibiotic resistance worldwide and require special attention. (frontiersin.org)
- While A. baumannii has been isolated from the wider environment such as water, soil, and animals, most studied isolates come from clinical samples, where A. baumannii has become a serious health problem, particularly in the intensive care unit, where it can cause serious and prolonged outbreaks ( Gonzalez-Villoria and Valverde-Garduno, 2016 ). (frontiersin.org)
- Of 96 A. baumannii clinical isolates, 66 strains carried class 1 integrons (no class 2 or 3 integrons were found). (ebscohost.com)
- This study was conducted to determine the prevalence and the local antibiogram of multidrug-resistant Acinetobacter baumannii isolates in Al-Hussein Hospital at King Hussein Medical Centre in Amman, Jordan. (ebscohost.com)
- The rapid detection of antibiotic resistance in clinical isolates of Acinetobacter baumannii would shorten the period during which patients receive empirical therapy and facilitate the early initiation of directed antibiotic therapy. (ovid.com)
- The objective of this study was to evaluate the ability of a real-time PCR assay to detect antibiotic resistance to four clinically relevant antibiotics from different antibiotic classes in clinical isolates of A. baumannii. (ovid.com)
- The growth of 48 clinical isolates of A. baumannii with a broad range of MICs of imipenem, ciprofloxacin, colistin and amikacin was evaluated using a real-time PCR assay targeting a highly conserved region of the ompA gene. (ovid.com)
- Despite a relatively low virulence of Acinetobacter baumannii isolates, emerging multidrug-resistant (MDR) strains to pose a formidable threat to patients, particularly in ill patients in intensive care unit (ICU). (magiran.com)
- Fifty-five non-repetitive A. baumannii isolates were examined for antimicrobial susceptibility, oxacillinase genes, class 1 integrons and genetic relationships by PFGE. (magiran.com)
- Isolates were identified by using the morphology of the colonies in selective media, MicroScan and the ability to grow at 44degrees C. Risk factors of the patients with or without nosocomial acquisition of A. baumannii were compared. (koreamed.org)
- DNA hybridization experiments showed that the presence of strain 19606 genes encoding regulatory and attachment or biofilm functions is widespread among other A. baumannii clinical isolates. (asm.org)
- Literature searches showed that there are numerous reports describing either the different types of infections caused by A. baumannii , the antibiotic resistance profiles of the different clinical strains, the characterization of some of the genetic elements responsible for their antibiotic resistance, or the development and application of typing methods and fingerprinting systems used to identify and trace the sources of clinical isolates of this pathogen. (asm.org)
- Most of the A. baumannii isolates were obtained from intensive care unit (ICU) ward of hospitals. (eurekaselect.com)
- In contrast to their synergistic effect against carbapenem-resistant A. baumannii isolates, colistin and tigecycline were highly antagonistic to carbapenem-resistant A. baumannii strains isolated from patients with VAP when the drugs were administered together. (medsci.org)
- These diseases involve a group of isolates represented by members of the " A. calcoaceticus-A. baumannii (Acb) complex," which are relevant to human health since they are associated with intra- and extranosocomial infections worldwide ( 9 ). (asm.org)
- Fifty clinical isolates of multidrug-resistant (MDR) A. baumannii were analyzed for clonal relatedness, serum resistance, biofilm formation, and in vivo assays. (springer.com)
- Lee HW, Koh YM, Kim J et al (2008) Capacity of multidrug-resistant clinical isolates of Acinetobacter baumannii to form biofilm and adhere to epithelial cell surfaces. (springer.com)
- Mirshekar M, Shahcheraghi F, Azizi O et al (2018) Diversity of class 1 integrons, and disruption of carO and dacD by insertion sequences among Acinetobacter baumannii isolates in Tehran, Iran. (springer.com)
- In 2004 and 2005, 5 metallo-beta-lactamase (MBL)-positive Acinetobacter baumannii isolates were found in 2 Greek hospitals. (cdc.gov)
- Whole genome sequencing of clinical isolates of Acinetobacter baumannii collected in Japan was performed. (nii.ac.jp)
- Comparative genome-wide association studies using A. baumannii isolates collected and isolates in public databases was performed to identify genetic traits of the pandemic lineages. (nii.ac.jp)
- The following numbers of clinical isolates were tested: Enterococcus faecalis (n = 135), Enterococcus faecium (n = 227), P. aeruginosa (n = 295) and A. baumannii (n = 158). (deepdyve.com)
- This study determined the prevalence of MDR A. baumannii isolates from intensive care units in a large tertiary-care hospital in Ismailia, Egypt, and the occurrence of different beta-lactamases in these isolates. (who.int)
- Accordingly, we examined the antibiotic activity of gallium protoporphyrin IX (Ga-PPIX) against a collection of A. baumannii strains, including nonmilitary and military strains and strains representing different clonal lineages and isolates classified as susceptible or MDR. (iupui.edu)
- Source of detection of the carbapenem-nonsusceptible A. baumannii-calcoaceticus complex isolates collected in the study. (springermedizin.de)
- Raman spectroscopy-based cluster analysis of Acinetobacter baumannii-calcoaceticus complex isolates from adult and ER-ICUs. (springermedizin.de)
- Note: Raman spectra correlation matrix of carbapenem-nonsusceptible A. baumannii-calcoaceticus complex isolates. (springermedizin.de)
- All isolates of acinetobacter baumannii (n=32) were resistant to ampicillin, ceftriaxone and ceftazidime but sensitive to polymyxin B. (thefreedictionary.com)
- Results: All 88 isolates were identified as Acinetobacter baumannii by Vitek-2 system and were shown to carry a blaOXA-51-like gene. (ed.ac.uk)
- PFGE analysis of 405 A. baumannii - calcoaceticus complex isolates detected 15 A. baumannii endemic/epidemic PFGE types (EE1 to EE15) that grouped into five clusters: EE1-EE8, EE9, EE10, EE11 and EE12-EE15. (biomedcentral.com)
- PFGE analysis of the 405 A. baumannii - calcoaceticus complex isolates returned 120 different PFGE types. (biomedcentral.com)
- Fifteen PFGE types, however, covering 231 A. baumannii isolates, were considered endemic or epidemic, and selected for further study. (biomedcentral.com)
- The aim of this study was to determine the origin of extensively drug-resistant (XDR) A. baumannii isolates in our hospital during 2009. (jidc.org)
- Isolates of A. baumannii were obtained from patients hospitalized during 2009. (jidc.org)
- Results: A total of 48 isolates of A. baumannii were isolated during 2009, corresponding to 34 patients. (jidc.org)
- Conclusions: During 2009, all XDR A. baumannii isolates were recovered from patients coming from other hospitals, indicative of inter-hospital transmission. (jidc.org)
- Plasmid borne Carbapenem-Hydrolyzing Class D β-Lactamases (CHDLs) and AdeABC efflux pump conferring carbapenem-tigecycline resistance among Acinetobacter baumannii isolates harboring TnAbaRs. (semanticscholar.org)
- Here we studied the prevalence and mechanisms of simultaneous resistance to carbapenem and tigecycline and accumulation of resistance determinants reservoirs in genome of Acinetobacter baumannii (A. baumannii) clinical isolates. (semanticscholar.org)
- METHODS: Consecutive clinical isolates of carbapenem resistant A. baumannii complex were collected between February and July 2010. (up.ac.za)
- The properties of tigecycline i.e. stability, safety, low toxicity, non cross-resistance with other antibiotics and its efficacy against multi-drug resistant A. baumannii isolates make it a good choice. (up.ac.za)
- Because routine identification in the clinical microbiology laboratory is not yet possible, Acinetobacter isolates are divided and grouped into three main complexes: Acinetobacter calcoaceticus-baumanii complex: glucose-oxidising nonhemolytic, (A. baumannii can be identified by OXA-51 typing) Acinetobacter lwoffii: glucose-negative nonhemolytic Acinetobacter haemolyticus: hemolytic Different species of bacteria in this genus can be identified using fluorescence-lactose-denitrification to find the amount of acid produced by metabolism of glucose. (wikipedia.org)
- Hombach, Michael;Jetter, Marion;Blöchliger, Nicolas;Kolesnik-Goldmann, Natalia;Keller, Peter M;Böttger, Erik C 2018-02-01 00:00:00 Abstract Background We investigated the feasibility of rapid disc diffusion antibiotic susceptibility testing (rAST) with reading of inhibition zones after 6 and/or 8 h of incubation for Enterococcus faecalis, Enterococcus faecium, Pseudomonas aeruginosa and Acinetobacter baumannii. (deepdyve.com)
- ABSTRACT Multi-drug resistant (MDR) strains of Acinetobacter baumannii are responsible for an increasing number of opportunistic infections in hospitals. (who.int)
- Acinetobacter baumannii is an emerging bacterial pathogen of considerable health care concern. (nih.gov)
- Acinetobacter baumannii is an opportunistic pathogen and is a problem in the hospital setting in US and Europe. (thelabrat.com)
- Acinetobacter baumannii is an opportunistic pathogen associated with severe hospital infections ( 1 , 16 ), which often need the use of carbapenems as the treatment of last resort. (asm.org)
- Multi-drug resistant (MDR) Acinetobacter baumannii is a major nosocomial pathogen causing a wide range of clinical conditions with significant mortality rates. (frontiersin.org)
- In this work, we show that the opportunistic pathogen Acinetobacter baumannii senses and responds to blue light. (asm.org)
- Acinetobacter baumannii is an opportunistic pathogen that has been held responsible for a lot of infections worldwide. (springer.com)
- Acinetobacter baumannii has emerged as an opportunistic pathogen among acutely ill patients, especially those with thermal injury. (cambridge.org)
- Here we provide evidence that DHA, an omega-3 fatty acid, has superior antimicrobial effects upon the highly drug-resistant pathogen Acinetobacter baumannii , thereby providing insights into one of the potential health benefits of omega-3 fatty acids. (asm.org)
- Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones. (sigmaaldrich.com)
- Acinetobacter baumannii has emerged as a pan-drug-resistant pathogen and displays a remarkable ability to persist in hospital settings despite desiccation and antimicrobial treatment. (sigmaaldrich.com)
- We sought to identify non-native ligands capable of blocking or promoting AbaR activity in A. baumannii for use as chemical probes to modulate QS phenotypes in this pathogen. (sigmaaldrich.com)
- In this study, we screened an open-source Pathogen Box library for anti- A. baumannii compounds. (mmv.org)
- Purpose: As an opportunistic pathogen, Acinetobacter baumannii causes various nosocomial infections. (ebscohost.com)
- We have characterized the kinetic properties of FolD from the Gram-negative pathogen Acinetobacter baumanni and determined high-resolution crystal structures of complexes with a cofactor and two potent inhibitors. (biomedsearch.com)
- The opportunistic pathogen Acinetobacter baumannii is able to persist in the environment and is often multidrug resistant (MDR), causing difficulties in the treatment of infections. (asm.org)
- IMPORTANCE Acinetobacter baumannii is a nosocomial pathogen and is an increasing problem in hospitals worldwide. (asm.org)
- Acinetobacter baumannii is an opportunistic pathogen that commonly causes nosocomial infections, such as ventilator-associated pneumonia and skin, soft tissue, wound, and bloodstream infections ( 1 ). (asm.org)
- BACKGROUND: Acinetobacter baumannii is an important nosocomial pathogen being reported with increasing frequency in outbreaks during the past decade. (koreamed.org)
- The ability of Acinetobacter sp to form biofilms, resist desiccation and persist on hospital surfaces has played a critical role in the emergence of this bacterium as a human pathogen. (hud.ac.uk)
- The ability of clinical strains of A. baumannii to form strong adherent biofilms has also been recognised as a key virulence factor for this pathogen. (hud.ac.uk)
- Acinetobacter baumannii is a metabolically versatile pathogen that causes severe infections in compromised patients. (asm.org)
- Acinetobacter baumannii is being increasingly recognized as an important pathogen that causes severe infections in hospitalized patients ( 6 , 7 ). (asm.org)
- Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen that causes major public health concerns, especially in hospitalized patients due to acquisition of resistant genes. (eurekaselect.com)
- Paterson, D.L. Acinetobacter baumannii: emergence of a successful pathogen. (eurekaselect.com)
- All these observations provide strong evidence showing the capacity of A. baumannii to sense light and interact with biotic and abiotic surfaces using undetermined alternative sensing and regulatory systems as well as alternative adherence and motility cellular functions that allow this pathogen to persist in different ecological niches. (asm.org)
- As a facultative pathogen that lives in different ecological niches, A. baumannii uses a wide range of extracellular signals to adapt to either an environmental or a host lifestyle, with each style playing a critical role in the less understood life cycle and ecology of this bacterium. (asm.org)
- Acinetobacter baumannii is a globally important nosocomial pathogen associated with clinical infections that are difficult to treat due to broad antimicrobial resistance. (unina.it)
- Acinetobacter baumannii is an emerging gram-negative nosocomial pathogen responsible for an increasing number of infections, especially among intensive-care-unit patients. (thefreedictionary.com)
- Acinetobacter baumannii has been considered the prevailing pathogen responsible for ventilator-associated pneumonia (VAP), a condition associated with high morbidity and mortality, among patients in Intensive Care Units (ICUs). (thefreedictionary.com)
- Acinetobacter baumannii is a Gram-negative, non-fermenting bacillus that has developed into an important nosocomial pathogen, affecting millions of patients worldwide. (ed.ac.uk)
- Z96926 Acinetobacter baumannii waaA gene, strain ATCC 19606. (atcc.org)
- These bacterial responses depend on the expression of the A. baumannii ATCC 17978 A1S_2225 gene, which codes for an 18.6-kDa protein that contains an N-terminal b lue- l ight-sensing- u sing f lavin (BLUF) domain and lacks a detectable output domain(s). (asm.org)
- In the present study, we investigated the role of Omp33 in fitness and virulence of A. baumannii by using an isogenic knockout strain deficient in the omp33 gene (JPAB02), derived from the ATCC 17978 wild-type (wt). (nih.gov)
- Transcriptional analyses of Acinetobacter baumannii ATCC 17978 showed that the expression of A1S_2091 was enhanced in cells cultured in darkness at 24°C through a process that depended on the BlsA photoreceptor. (asm.org)
- This concentration significantly reduced bacterial viability, while 40 μg/ml killed all cells of the A. baumannii ATCC 19606(T) and ACICU MDR isolate after 24-h incubation. (iupui.edu)
- Fetch the A. baumannii ATCC 17978 stock stored at -80 °C, scrape the surface of the frozen stock, and plate it on a LB agar. (bio-protocol.org)
- New research finds curcumin combined with a polyphenol in green tea and other foods and herbs will inhibit multi-drug resistant Acinetobacter baumannii - often at the root of hospital-acquried pneumonia infections. (greenmedinfo.com)
- Multi-drug resistant Acinetobacter baumannii bacteria inside biofilm, computer illustration. (sciencephoto.com)
- Extensively and multi-drug resistant A. baumannii (AB) represent an emerging threat in hospitals locally and worldwide. (clinicaltrials.gov)
- Further, the effect of TC and EG on the expression of A. baumannii genes encoding resistance to β-lactam antibiotics ( blaP ), efflux pumps ( adeABC ), and multi-drug resistant protein ( mdrp ) was studied using real-time quantitative PCR (RT-qPCR). (frontiersin.org)
- Using a combination of short- and long-read DNA sequencing, we have investigated the location of antibiotic resistance genes and characterized mobile genetic elements (MGEs) in three clinical multi-drug resistant Acinetobacter baumannii . (frontiersin.org)
- A. baumannii integrons cassettes carried multi-drug-resistant gene codes. (ebscohost.com)
- Multi drug resistant (MDR) strains of Acinetobacter baumannii have emerged as a major cause of nosocomial infections associated with significant morbidity and mortality. (hud.ac.uk)
- Prevalence of multi drug resistant Acinetobacter baumannii in the clinical samples from Tertiary Care Hospital in Islamabad, Pakistan. (thefreedictionary.com)
- Carbapenems are used as a last resort for treating patients infected with resistant or multi-drug resistant (MDR) Acinetobacter baumannii. (ed.ac.uk)
- BACKGROUND: The presence of multi-drug resistant Acinetobacter baumannii raises a big therapeutic challenge in our hospital. (up.ac.za)
- Treatment options for infections due to carbapenem and multi-drug resistant A. baumannii organisms are limited and hence tigecycline and amikacin may be considered. (up.ac.za)
- Material and Methods: Observational, longitudinal, retrospective study, through file consult, of patients admitted at UUM from 01/2005 to 12/2011, with A. baumannii VAP/TAV, treated with inhaled colistin. (ersjournals.com)
- Conclusions: On critical patients, inhaled colistin was effective treating PAV/TAV due to extensively resistant A. baumannii. (ersjournals.com)
- These observations suggest that the use of carbapenems or colistin to treat severe multidrug-resistant A. baumannii infections may lead to the development of resistance. (asm.org)
- Cikman A, Gulhan B, Aydin M, Ceylan MR, Parlak M, Karakecili F, Karagoz A. In vitro Activity of Colistin in Combination with Tigecycline against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Patients with Ventilator-Associated Pneumonia. (medsci.org)
- This study investigated the minimum inhibitory concentration (MIC) values and in vitro activity of colistin in combination with tigecycline against carbapenem-resistant Acinetobacter baumannii strains isolated from patients with ventilator-associated pneumonia (VAP) using the E-test method. (medsci.org)
- While only 1 of 40 A. baumannii strains was determined to be colistin resistant, 6 were tigecycline resistant. (medsci.org)
- The MIC 50 , MIC 90 , and MIC intervals of the A. baumannii strains were 0.19, 1.5, and 0.064‒4 μg/ml for colistin and 1, 8, and 0.094‒256 μg/ml for tigecycline, respectively. (medsci.org)
- In this study we explored alternative output parameters to assess the activities of colistin and meropenem against Pseudomonas aeruginosa and Acinetobacter baumannii. (diva-portal.org)
- Methods: Four strains each of P. aeruginosa and A. baumannii were exposed to colistin and meropenem, alone and in combination, in 8h dynamic time-kill experiments. (diva-portal.org)
- Conclusions: Combination effects were frequently found with colistin and meropenem against P. aeruginosa and A. baumannii in time-kill experiments but were not detected with the checkerboard method. (diva-portal.org)
- A. baumannii in our hospital were highly resistant to all antibiotics, including tigecycline, except for minocycline and colistin which are considered the last resort treatment for multidrug-resistant A. baumannii. (who.int)
- Colistin and fusidic acid, a novel potent synergistic combination for treatment of multidrug-resistant Acinetobacter baumannii infections. (springermedizin.de)
- Combinations including colistin, rifampicin and fosphomycin could be an appropriate alternative for infections provoked by both Pseudomonas and Acinetobacter [ 15 - 17 ]. (alliedacademies.org)
- A. baumannii strains are equipped with a multitude of antibiotic resistance mechanisms, rendering them resistant to most of the currently available antibiotics. (frontiersin.org)
- This study investigated the efficacy of two food-grade, plant-derived antimicrobials (PDAs), namely trans -cinnamaldehyde (TC) and eugenol (EG) in decreasing A. baumannii 's resistance to seven β-lactam antibiotics, including ampicillin, methicillin, meropenem, penicillin, aztreonam, amoxicillin, and piperacillin. (frontiersin.org)
- A. baumannii strains not exposed to the PDAs or antibiotics served as controls. (frontiersin.org)
- From these perspectives, adjunctive EPI + antibiotics therapeutic strategies may prove to be a promising approach for treating A. baumannii bacteremia. (rochester.edu)
- Toward those goals we have: A. identified and characterized two novel EPI backbones that potentiate the activity of antibiotics against A. baumannii in a serum-specific manner and B. identified fourteen transposon mutants that exhibit a decrease in serum-specific efflux of antibiotics. (rochester.edu)
- 4-Hydroxybenzaldehyde (4-HBA), which cannot support the growth of Acinetobacter baumannii , exhibited synergism only with amphenicol antibiotics including chloramphenicol (CAM) and thiamphenicol. (springer.com)
- Damier-Piolle L, Magnet S, Bremont S, Lambert T, Courvalin P (2008) AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii . (springer.com)
- Additionally, chemical scaffolds of DHFR inhibitors that are effective as antibiotics against A. baumannii were identified using an in vitro DHFR activity assay and A. baumannii growth inhibition. (mmv.org)
- The use of real-time PCR to monitor bacterial growth in the presence of antibiotics is effective for rapidly identifying antibiotic resistance in A. baumannii. (ovid.com)
- The developing resistance patterns seen in Acinetobacter sp suggest that the number of effective antibiotics may shortly be exhausted. (hud.ac.uk)
- Ye, Y. Genomic sequencing of a strain of Acinetobacter baumannii and potential mechanisms to antibiotics resistance. (eurekaselect.com)
- D ) Minimum inhibitory concentration (MIC) of select antibiotics in A. baumannii . (elifesciences.org)
- Accordingly, our work and that of others showed that A. baumannii senses and responds to extracellular signals, including iron limitation, changes in salt concentrations, desiccation stress, and the presence of antibiotics and disinfectants ( 17 ). (asm.org)
- A paucity of effective, currently available antibiotics and a lull in antibiotic development pose significant challenges for treatment of patients with multidrug-resistant (MDR) Acinetobacter baumannii infections. (iupui.edu)
- The emergence of multidrug resistance among Acinetobacter baumannii is leading to an increasing dependence on the use of polymyxins as last-hope antibiotics. (utexas.edu)
- They observed that Acinetobacter outbreaks were mainly reported from intensive care units, after use of antibiotics and during mechanical ventilation. (hhmglobal.com)
- We describe the prevalence of invasive carbapenem-resistant Acinetobacter spp. (springer.com)
- Here we report on the temporal and regional analysis of invasive carbapenem-resistant Acinetobacter isolated in Switzerland from 2005 to 2016. (springer.com)
- A 4-year surveillance of carbapenem-resistant Acinetobacter spp. (asm.org)
- Determines the citywide prevalence and inter-hospital spread of endemic carbapenem-resistant Acinetobacter species in Brooklyn, New York. (ebscohost.com)
- Among these threats, the rapid increase in carbapenem-resistant Acinetobacter baumannii (CRAB) is a particularly challenging global issue in the health care setting. (jcvi.org)
- Growth characteristics of A. baumannii mutant library members with increased serum susceptibility. (nih.gov)
- We report a patient infected with A . baumannii that lacked susceptibility to all commercially available antimicrobial drugs. (cdc.gov)
- Clonally related strains of Acinetobacter that differ in susceptibility patterns may coexist within a single hospital, dependent on the selective pressure related to antibiotic exposure. (cambridge.org)
- The aim of the present study was to determine the genetic relatedness and antimicrobial susceptibility patterns in the endemic clones of A. baumannii isolated from patients in the ICU. (magiran.com)
- Kipnis, A. Acinetobacter baumannii strains isolated from patients in intensive care units in Goiânia, Brazil: Molecular and drug susceptibility profiles. (eurekaselect.com)
- Rapid disc diffusion antibiotic susceptibility testing for Pseudomonas aeruginosa, Acinetobacter baumannii and Enterococcus spp. (deepdyve.com)
- Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility. (bio-protocol.org)
- However, ongoing monitoring of A. baumannii susceptibility to tigecycline is needed. (up.ac.za)
- The aim of this study was to systematically review the published data on the prevalence and dispersion of metallo-β-lactamases (MBLs) genes in A. baumannii in different provinces of Iran and provide an overall prevalence rate using meta-analysis. (eurekaselect.com)
- Unfortunately, very little research has been devoted exclusively to investigating Acinetobacter baumannii prevalence, resistance and pathogenicity in Kuwaiti Hospitals. (ed.ac.uk)
- In contrast, "non-ACB " Acinetobacter species generally present lower pathogenicity and are often found in the environment. (springer.com)
- Since it remains unclear how to treat bacteremia caused by AB, the present study aims to enroll patients at multiple sites with extensively drug resistant Acinetobacter species bacteremia receiving different combination therapy to assess treatment outcomes and analyze risk factors associated with mortality. (clinicaltrials.gov)
- Blood sample will be collected on the day of enrollment (Day 0), Day 1, 2, 3 and 7 for PCR identification and quantification of Acinetobacter species. (clinicaltrials.gov)
- Acinetobacter baumannii is a non-fermenting Gram-negative bacilli and it is the second most common species after Pseudomonas aeruginosa in this group causing bacterial infections ( Gonzalez-Villoria and Valverde-Garduno, 2016 ). (frontiersin.org)
- The lice excreted living Acinetobacter species within their feces. (ajtmh.org)
- Acinetobacter species as a cause of catheter-related infections. (ajtmh.org)
- Distribution of Acinetobacter species on skin of healthy humans. (ajtmh.org)
- Park, W. Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy. (eurekaselect.com)
- Since the 2006 discovery of the Acinetobacter baumannii strain AYE AbaR1 resistance island, similar elements have been reported in numerous members of this species. (le.ac.uk)
- Acinetobacter species are oxidase-negative, exhibit twitching motility, and occur in pairs under magnification. (wikipedia.org)
- Species of the genus Acinetobacter are strictly aerobic, nonfermentative, Gram-negative bacilli. (wikipedia.org)
- The genus Acinetobacter comprises 38 validly named species. (wikipedia.org)
- Identification of Acinetobacter species is complicated by lack of standard identification techniques. (wikipedia.org)
- Acinetobacter species are widely distributed in nature, and commonly occur in soil and water. (wikipedia.org)
- Their ability to survive on moist and dry surfaces, as well as to survive exposure to various common disinfectants, allows some Acinetobacter species to survive in a hospital environment. (wikipedia.org)
- Furthermore, Acinetobacter species can grow at a broad range of temperatures, allowing them to survive in a broad array of environments. (wikipedia.org)
- Antibiogram of multidrug resistant Acinetobacter baumannii isolated from clinical specimens at King Hussein Medical Centre, Jordan: a retrospective analysis. (ebscohost.com)
- Introduction: Ventilator associated pneumonia and tracheobronchitis (VAP/VAT) due to multiresistant A. baumannii are preeminent causes of mortality and morbidity at ICU's. (ersjournals.com)
- Because of this, and because it is generally found in weakened patients, the mortality rate for infections with A. baumannii is high. (sciencephoto.com)
- While the organism is capable of producing an array of bacterial infections, A. baumannii bacteremia is a primary concern, resulting in mortality rates as high as 80% in certain patient populations. (rochester.edu)
- Infections caused by A. baumannii often lead to high morbidity and mortality, with limited treatment options. (springermedizin.de)
- The ability of the A. baumannii strains to survive under dry conditions varied greatly and correlated well with the source of the strain. (asm.org)
- A strain of Acinetobacter baumannii 6B92 isolated from the blood culture of a patient at the Edinburgh Royal Infirmary i 1985 was found to be resistant to imipenem, all classes of cephalosporins and penicillins. (nih.gov)
- Only the louse strain of A. baumannii was pathogenic for the body louse. (ajtmh.org)
- We report here the genetic and molecular analysis of the A. baumannii prototype strain 19606 by electroporation of transposon-transposase complexes. (asm.org)
- Leicester Research Archive: Deletion of TnAbaR23 results in both expected and unexpected antibiogram changes in a multidrug-resistant Acinetobacter baumannii strain. (le.ac.uk)
- Deletion of TnAbaR23 results in both expected and unexpected antibiogram changes in a multidrug-resistant Acinetobacter baumannii strain. (le.ac.uk)
- Most strains of Acinetobacter, except some of the A. lwoffii strain, grow well on MacConkey agar (without salt). (wikipedia.org)
- Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A . mBio, Vol. 9, Issue. (cambridge.org)
- Our analyses reveal that AA and DHA incorporate into the A. baumannii bacterial membrane and impact bacterial fitness and membrane integrity, with DHA having a more pronounced effect. (asm.org)
- Through transcriptional profiling and mutant analyses, we show that the A. baumannii β-oxidation pathway plays a protective role against AA and DHA, by limiting their incorporation into the phospholipids of the bacterial membrane. (asm.org)
- We found that mucin, either admixed with or separately injected with the challenge bacterial inoculum, was able to enhance the tissue and blood burdens of A. baumannii strains of different virulence. (asm.org)
- The results demonstrated that silver nanoparticles synthesized with E. critriodora leaf extract triggered MDR A. baumannii DNA condensation, induced bacterial cell death and had a significant effect on biofilm formation, biofilm-grown cells, bacterial attachment and invasion of human lung cells in a concentration dependent manner. (eurekamag.com)
- The results of this study showed that the lowest inhibitory concentration of the C. spinose ethanolic extract against A. baumannii was 25 ppm in which two bacterial strains were inhibited while the highest inhibitory concentration was 50 ppm and the highest concentration of fecundity was equal to 100 ppm. (alliedacademies.org)
- We proved that the pectate lyase domain is responsible for phage depolymerase activity and binding to specific Acinetobacter bacterial capsules. (uminho.pt)
- A. baumannii is a major cause of nosocomial infections affecting mainly to debilitating patients in the ICU, although the spread to regular wards and to long-term care facilities is increasing. (medscape.com)
- Successful clones of Acinetobacter baumannii cause a variety of nosocomial infections through serum resistance, biofilm formation, and antimicrobial resistance as virulence capabilities. (springer.com)
- Carbapenems, including meropenem, are currently considered the first-line agents for the treatment of infections caused by Acinetobacter spp. (asm.org)
- The Food and Drug Administration (FDA) is announcing this public workshop regarding the current state and further development of animal models for serious infections caused by Acinetobacter baumanii and Pseudomonas aeruginosa . (fda.gov)
- Al-Anazi K, Al-Jasser A. Infections caused by Acinetobacter baumannii in recipients of hematopoietic stem cell transplantation. (medigraphic.com)
- E. Dahdouh, S. H. Shoucair, S. E. Salem, and Z. Daoud, "Mutant Prevention Concentrations of Imipenem and Meropenem against Pseudomonas aeruginosa and Acinetobacter baumannii ," The Scientific World Journal , vol. 2014, Article ID 979648, 7 pages, 2014. (hindawi.com)
- Zarrilli, R. Acinetobacter baumannii virulence determinants involved in biofilm growth and adherence to host epithelial cells. (eurekaselect.com)
- The University Hospital and the New Jersey Department of Health are working together to control acinetobacter and are employing all possible methods to control any issue that may arise. (inquisitr.com)
- Methods: Here, we used CADY, a secondary amphipathic peptide of 20 residues that could successfully carry siRNA into mammalian cells, to prepare CADY/ASOs nanoparticles (CADY-NPs) targeting acpP (encoding acyl carrier protein), and evaluated the uptake features, the inhibitory effects of CADY-NPs on gene expression and the growth of MDR-A. baumannii. (eurekaselect.com)
- A total of 40 A. baumannii strains, identified using the Phoenix Automated Microbiology System (Becton, Dickinson and Co., Franklin Lakes, NJ, USA) by conventional methods, were included in this study. (medsci.org)
- Methods In total, 815 clinical strains [E. faecalis (n = 135), E. faecium (n = 227), P. aeruginosa (n = 295) and A. baumannii (n = 158)] were included in this study. (deepdyve.com)
- Methods: Twelve strains of A. baumannii were isolated from patients who referred to hospitals in Zabol. (alliedacademies.org)
- Methods: A total of 88 Acinetobacter baumannii samples were collected from the Mubarak Al- Kabeer Hospital, over a three year period, 2006-2008, and they were identified phenotypically, by Vitek-2 systems, and then genotypically by PCR amplification of blaOXA-51-like gene. (ed.ac.uk)
- The aim of the present work was to study the endemic and epidemic clones of A. baumannii in a not previously studied single hospital over a long period, and to compare them, using the aforementioned genotyping methods, with other nosocomial clones circulating in Spain. (biomedcentral.com)
- Rolain, J-M. Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options. (eurekaselect.com)
- The increasing multidrug resistance of Acinetobacter baumannii has been highlighted as a worldwide therapeutic problem. (eurekamag.com)
- These results indicate that Ga-PPIX could be a viable therapeutic option for treatment of recalcitrant A. baumannii infections regardless of the resistance phenotype, clone lineage, time and site of isolation of strains causing these infections and their iron uptake phenotypes or the iron content of the media. (iupui.edu)
- This study demonstrates the role of the A. baumannii efflux pump AdeB, and its regulator AdeRS, in multidrug resistance, epithelial cell killing, and biofilm formation. (asm.org)
- Darwish SA, Rasooli I, Mousavi SG (2017) Filamentous hemagglutinin adhesin FhaB limits A. baumannii biofilm formation. (springer.com)
- Zarrilli, R. Virulence-related traits of epidemic Acinetobacter baumannii strains belonging to the international clonal lineages I-III and to the emerging genotypes ST25 and ST78. (eurekaselect.com)
- Septicemia and ventilator-associated pneumonia are two of the more severe forms of A. baumannii disease. (nih.gov)
- The results revealed that disruption of A. baumannii phospholipase D (PLD) caused a reduction in the organism's ability to thrive in serum, a deficiency in epithelial cell invasion, and diminished pathogenesis in a murine model of pneumonia. (nih.gov)
- Although the pneumonia showed radiographic response to the antimicrobial drug therapy, A . baumannii continued to be isolated from respiratory secretions on numerous occasions. (cdc.gov)
- Community-acquired Acinetobacter pneumonia: a case report. (ajtmh.org)
- Objective To observe and compare the clinical efficacy of tigecyclinc combined with imipenem/cilastation,imipenem/cilastation combined with cefoperazone sulbacta,prolonging intravenous infusion of imipenem/cilastatin combined with cefoperazone sulbactam on severe pan-resistance Acinetobacter baumannii. (cnki.com.cn)
- A ) Genomic organization of the A. baumannii mlaFEDCB operon and its predicted products. (elifesciences.org)
- Genome sequencing revealed that most were Acinetobacter baumannii , whereas seven represented other Acinetobacter spp. (asm.org)
- Here, we report a strategic approach with the 3766 proteins from the whole genome of A. baumannii ATCC19606 (AB) to rationally identify plausible. (medworm.com)
- A bioinformatics analysis showed that the whole genome sequence of phage Βϕ-R3177 exhibited 62% sequence similarity to that of Acinetobacter phage Βϕ-B1252, but there was no homology seen with other phages. (jcvi.org)
- Using pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and multiple locus variable number tandem repeat sequence (VNTR) analysis (MLVA), the present work examines the genetic diversity of the endemic and epidemic A. baumannii clones isolated in a single hospital over a twelve-year period. (biomedcentral.com)
- AF100557 Acinetobacter baumannii DNA gyrase A (gyrA) gene, partial cds. (atcc.org)
- Therefore, the A1S_2225 gene, which is present in several members of the Acinetobacter genus, was named b lue- l ight- s ensing A ( blsA ). (asm.org)
- Mutation of the ctp gene reduced invasion and adhesion of A. baumannii to airway epithelial cells, potentially due to increased hydrophobicity. (mdpi.com)
- Taken together, the ctp gene in A. baumannii has a pivotal role in maintaining membrane integrity, adaptation to environmental stress, and controlling virulence. (mdpi.com)
- We believe that integrons cassettes gene could be taken as a marker of prognosticating A. baumannii antimicrobial resistance, but only reveal partial drug resistance profiles. (ebscohost.com)
- This addition is performed in Salmonella enterica serovar Typhimurium by the product of the pmrC gene, which is a homolog of the pmrC gene from Acinetobacter. (utexas.edu)
- Knockout of this gene in the mutant R2 [pmrB(T235I)] reversed resistance as well as phosphoethanolamine modification of lipid A. These results demonstrate that specific alterations in the sequence of the pmrCAB operon are responsible for resistance to polymyxins in A. baumannii. (utexas.edu)
- Acinetobacter baumannii is a gram-negative aerobic bacillus that primarily causes hospital-acquired infections affecting specially to debilitated patients with prolonged hospitalization and with long-term exposition to antimicrobials. (medscape.com)
- A. baumannii exhibits a wide variety of mechanisms of resistance to antimicrobial agents. (medscape.com)
- Harding CM, Hennon SW, Feldman MF (2018) Uncovering the mechanisms of Acinetobacter baumannii virulence. (springer.com)
- The emergence of infections associated to new antimicrobial resistance in Acinetobacter baumannii (Ab) genotypes represents a major challenge. (monash.edu)
- Risk factors, clinical presentation, and outcome of Acinetobacter barumannii bacteremia. (medigraphic.com)
- This prospective study was initiated to identify risk factors for the nosocomial acquisition of A. baumannii in patients admitted into a medical intensive care unit (MICU). (koreamed.org)
- Over the last 20 years a worldwide expansion in Acinetobacter infections has been observed associated with intensive care units (ICUs), long term care facilities and wounded armed forces personnel. (hud.ac.uk)
- Acinetobacter baumannii causes severe infections that primarily affect intensive care unit (ICU) patients. (jidc.org)
- In July 2010, a team in New Delhi reported a cluster of three cases of Acinetobacter baumannii bearing blaNDM-1 that were found in the intensive care unit of a hospital in Chennai, India, in April 2010. (wikipedia.org)
- The two PDAs inhibited the function of A. baumannii efflux pump, (AdeABC), but did not increase the permeability of its outer membrane. (frontiersin.org)
- Acinetobacter baumannii is the cause of difficult-to-treat infections in healthcare settings in Europe due to its increasing resistance to antimicrobial agents, in particular the carbapenems. (news-medical.net)
- Al-Agamy MH, Khalaf NG, Tawfick MM, Shibl AM, El Kholy A (2014) Molecular characterization of carbapenem-insensitive Acinetobacter baumannii in Egypt. (springer.com)
- Indicates wild type A. baumannii containing pMMB plasmid constructs, and cultures grown with the addition of kanamycin (25 μg/mL) to maintain plasmids and 50 μM IPTG for induction. (elifesciences.org)