Infections with bacteria of the genus ACINETOBACTER.
A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.
A species of gram-negative, aerobic bacteria found in soil and water. Although considered to be normally nonpathogenic, this bacterium is a causative agent of nosocomial infections, particularly in debilitated individuals.
A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Substances that reduce the growth or reproduction of BACTERIA.
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Any infection which a patient contracts in a health-care institution.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.
Proteins found in any species of bacterium.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)
An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. EC
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
The functional hereditary units of BACTERIA.
A genus of gram-negative, aerobic, motile bacteria that occur in water and soil. Some are common inhabitants of the intestinal tract of vertebrates. These bacteria occasionally cause opportunistic infections in humans.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
Derivatives of adipic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,6-carboxy terminated aliphatic structure.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
Hospital units providing continuous surveillance and care to acutely ill patients.
A genus of gram-negative, aerobic bacteria occurring as rods (subgenus Moraxella) or cocci (subgenus Branhamella). Its organisms are parasitic on the mucous membranes of humans and other warm-blooded animals.
Using MOLECULAR BIOLOGY techniques, such as DNA SEQUENCE ANALYSIS; PULSED-FIELD GEL ELECTROPHORESIS; and DNA FINGERPRINTING, to identify, classify, and compare organisms and their subtypes.
Hospitals which provide care for the military personnel and usually for their dependents.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes.
The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.
The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.
Institutions with an organized medical staff which provide medical care to patients.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Direct nucleotide sequencing of gene fragments from multiple housekeeping genes for the purpose of phylogenetic analysis, organism identification, and typing of species, strain, serovar, or other distinguishable phylogenetic level.
A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC and EC
Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)
The genetic complement of a BACTERIA as represented in its DNA.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Inflammation of the lung parenchyma that is caused by bacterial infections.
Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).
D-Glucose:1-oxidoreductases. Catalyzes the oxidation of D-glucose to D-glucono-gamma-lactone and reduced acceptor. Any acceptor except molecular oxygen is permitted. Includes EC; EC; EC and EC
Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by cross bacterial infections in hospitals (NOSOCOMIAL INFECTIONS).
The relationships of groups of organisms as reflected by their genetic makeup.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Bacteria which retain the crystal violet stain when treated by Gram's method.
A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.
Refuse liquid or waste matter carried off by sewers.
A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)
Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.
An acid which is found in cinchona bark and elsewhere in plants. (From Stedman, 26th ed)
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
The study of microorganisms living in a variety of environments (air, soil, water, etc.) and their pathogenic relationship to other organisms including man.
A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.
Complex petroleum hydrocarbons consisting mainly of residues from crude oil distillation. These liquid products include heating oils, stove oils, and furnace oils and are burned to generate energy.
Nonsusceptibility of bacteria to the antibiotic KANAMYCIN, which can bind to their 70S ribosomes and cause misreading of messenger RNA.
Invasion of the site of trauma by pathogenic microorganisms.
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.
Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
Techniques used in studying bacteria.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.
The immediate physical zone surrounding plant roots that include the plant roots. It is an area of intense and complex biological activity involving plants, microorganisms, other soil organisms, and the soil.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.
Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid).
Infections with bacteria of the genus PSEUDOMONAS.
A flavoprotein that catalyzes the synthesis of protocatechuic acid from 4-hydroxybenzoate in the presence of molecular oxygen. EC
Any materials used in providing care specifically in the hospital.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Linear polymers in which orthophosphate residues are linked with energy-rich phosphoanhydride bonds. They are found in plants, animals, and microorganisms.
Simultaneous resistance to several structurally and functionally distinct drugs.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
A group of enzymes that catalyzes the transfer of a phosphate group onto a phosphate group acceptor. EC 2.7.4.
A glucose dehydrogenase that catalyzes the oxidation of beta-D-glucose to form D-glucono-1,5-lactone, using NAD as well as NADP as a coenzyme.
Lice of the genus Pediculus, family Pediculidae. Pediculus humanus corporus is the human body louse and Pediculus humanus capitis is the human head louse.
Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1117)
Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Programs of disease surveillance, generally within health care facilities, designed to investigate, prevent, and control the spread of infections and their causative microorganisms.
The presence of bacteria, viruses, and fungi in water. This term is not restricted to pathogenic organisms.
A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
Infections by bacteria, general or unspecified.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Hospital department which manages and provides the required housekeeping functions in all areas of the hospital.
Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.
Parasitic attack or subsistence on the skin by members of the order Phthiraptera, especially on humans by Pediculus humanus of the family Pediculidae. The hair of the head, eyelashes, and pubis is a frequent site of infestation. (From Dorland, 28th ed; Stedman, 26th ed)
The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC).
Drug metabolizing enzymes which oxidize methyl ethers. Usually found in liver microsomes.
Oxidoreductases that are specific for ALDEHYDES.
Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.
Inanimate objects that carry pathogenic microorganisms and thus can serve as the source of infection. Microorganisms typically survive on fomites for minutes or hours. Common fomites include CLOTHING, tissue paper, hairbrushes, and COOKING AND EATING UTENSILS.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
The capital is Seoul. The country, established September 9, 1948, is located on the southern part of the Korean Peninsula. Its northern border is shared with the Democratic People's Republic of Korea.
Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.
Care of a highly technical and specialized nature, provided in a medical center, usually one affiliated with a university, for patients with unusually severe, complex, or uncommon health problems.
A genus of gram-negative, aerobic, rod-shaped bacteria whose organisms are part of the normal flora of the mucous membranes of the upper respiratory tract. Some species are pathogenic for man.
Hospitals engaged in educational and research programs, as well as providing medical care to the patients.
A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
Former kingdom, located on Korea Peninsula between Sea of Japan and Yellow Sea on east coast of Asia. In 1948, the kingdom ceased and two independent countries were formed, divided by the 38th parallel.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A broad-spectrum antimicrobial carboxyfluoroquinoline.
Polysaccharides found in bacteria and in capsules thereof.
Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.
The presence of an infectious agent on instruments, prostheses, or other inanimate articles.
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
A family of BACTERIOPHAGES and ARCHAEAL VIRUSES which are characterized by complex contractile tails.
Persons including soldiers involved with the armed forces.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)
The goosefoot plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. It includes beets and chard (BETA VULGARIS), as well as SPINACH, and salt tolerant plants.
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.
Distinct units in some bacterial, bacteriophage or plasmid GENOMES that are types of MOBILE GENETIC ELEMENTS. Encoded in them are a variety of fitness conferring genes, such as VIRULENCE FACTORS (in "pathogenicity islands or islets"), ANTIBIOTIC RESISTANCE genes, or genes required for SYMBIOSIS (in "symbiosis islands or islets"). They range in size from 10 - 500 kilobases, and their GC CONTENT and CODON usage differ from the rest of the genome. They typically contain an INTEGRASE gene, although in some cases this gene has been deleted resulting in "anchored genomic islands".
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Specialized hospital facilities which provide intensive care for burn patients.
Measurable quantity of bacteria in an object, organism, or organism compartment.
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.
Cyclic esters of acylated BUTYRIC ACID containing four carbons in the ring.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.

Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes. (1/991)

Resting cells of Streptomyces griseus, Mucor mucedo, and a growing culture of Acinetobacter calcoaceticus when mixed with compounds related to 12,13-epoxytrichothec-9-ene-4beta,15-diacetoxy-3alpha-ol(anguidine) produced a series of derivatives that were either partially hydrolyzed or selectively acylated. These derivatives showed marked differences in activities as assayed by antifungal and tissue culture cytotoxicity tests.  (+info)

Effect of desiccation on the ultrastructural appearances of Acinetobacter baumannii and Acinetobacter lwoffii. (2/991)

An Acinetobacter baumannii isolate survived desiccation beyond 30 days and an Acinetobacter lwoffii isolate up to 21 days. For both species, desiccation resulted in a significant increase in the proportion of round cells (A baumannii, 40% to 80%; A lwoffii, 51% to 63%) and a significant decrease in rod shaped cells (A baumannii, 58% to 13%; A lwoffii, 46% to 34%). Electronmicroscopic examination showed that there was also a corresponding significant increase in the cell wall thickness (A baumannii, up to 53%; A lwoffii, up to 26%). Desiccated A baumannii cells became more electron-dense and had significantly thicker cell walls (x1.3) than those of A lwoffii. Cell wall structures of A baumannii strains with different abilities to resist desiccation deserve further study.  (+info)

Acinetobacter bacteremia in Hong Kong: prospective study and review. (3/991)

The epidemiological characteristics of 18 patients with acinetobacter bacteremia were analyzed. Patients (mean age, 55.5 years) developed bacteremia after an average of 14.1 days of hospitalization. Fifteen of 16 patients survived bacteremia caused by Acinetobacter baumannii. Cultures of blood from the remaining two patients yielded Acinetobacter lwoffii. Most patients (78%) resided in the general ward, while four patients (22%) were under intensive care. Genotyping by arbitrarily primed polymerase chain reaction analysis and the temporal sequence of isolation were more useful than phenotyping by antimicrobial susceptibility in the determination of the source of bacteremia, and the intravascular catheter was the leading infection source (39% of cases). The possibility of an association of glucose with the pathogenesis of acinetobacter infection was raised.  (+info)

Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case-control study of adult burn patients. (4/991)

Risk factors for Acinetobacter baumannii bloodstream infection (BSI) were studied in patients with severe thermal injury in a burn intensive care unit where A. baumannii was endemic. Of 367 patients hospitalized for severe thermal injury during the study period, 29 patients with nosocomial A. baumannii BSI were identified (attack rate, 7.9%). Cases were compared with 58 matched controls without A. baumannii BSI. The overall mortality rate was 31% among cases and 14% among controls; only two deaths (7%) were considered directly related to A. baumannii BSI. Molecular typing of A. baumannii blood isolates by means of randomly amplified polymorphic DNA analysis and pulsed-field gel electrophoresis revealed the presence of three different strain types. Multivariate analysis showed that female gender (P = .027), total body surface area burn of > 50% (P = .016), prior nosocomial colonization with A. baumannii at a distant site (P = .0002), and use of hydrotherapy (P = .037) were independently associated with the acquisition of A. baumannii BSI in burn patients. These data underscore the need for effective infection control measures for this emerging nosocomial problem.  (+info)

Phylogenetic structures of the genus Acinetobacter based on gyrB sequences: comparison with the grouping by DNA-DNA hybridization. (5/991)

The phylogenetic relationships of 49 Acinetobacter strains, 46 of which have previously been classified into 18 genomic species by DNA-DNA hybridization studies, were investigated using the nucleotide sequence of gyrB, the structural gene for the DNA gyrase B subunit. The phylogenetic tree showed linkages between genomic species 1 (Acinetobacter calcoaceticus), 2 (Acinetobacter baumannii), 3 and TU13; genomic species 6, BJ15, BJ16 and BJ17; genomic species 5, BJ13 (synonym of TU14) and BJ14; genomic species 7 (Acinetobacter johnsonii), 10 and 11; and genomic species 8 and 9. The phylogenetic grouping of Acinetobacter strains based on gyrB genes was almost congruent with that based on DNA-DNA hybridization studies. Consequently, gyrB sequence comparison can be used to resolve the taxonomic positions of bacterial strains at the level of genomic species. However, minor discrepancies existed in the grouping of strains of genomic species 8, 9 and BJ17. The phylogenetic tree for these strains was reconstructed from the sequence of rpoD, the structural gene for the RNA polymerase sigma 70 factor. The latter tree was 100% congruent with the grouping based on DNA-DNA hybridization. The reliability of DNA-DNA hybridization may be superior to that of sequence comparison of a single protein-encoding gene in resolving closely related organisms since the former method measures the homologies between the nucleotide sequences of total genomic DNAs. Three strains that have not been characterized previously by DNA-DNA hybridization seem to belong to two new genomic species, one including strain ATCC 33308 and the other including strains ATCC 31012 and MBIC 1332.  (+info)

Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii. (6/991)

From March 1995 to March 1997, sulbactam was prospectively evaluated in patients with non-life-threatening multiresistant Acinetobacter baumannii infections. During this period, 47 patients were treated with sulbactam; of them, five were excluded because they had received < or =48 h of sulbactam therapy. A total of 42 patients, 27 males and 15 females with a mean age of 60+/-15 years, were finally evaluated. Infections were as follows: surgical wound, 19; tracheobronchitis, 12; urinary tract, 7; catheter-related bacteraemia, 2; and pneumonia, 2. Eighteen patients received intravenous sulbactam alone (1 g every 8 h) and 24 patients received intravenous sulbactam/ampicillin (1 g:2 g every 8 h) with no major adverse effects. Of the 42 patients, 39 improved or were cured and showed A. baumannii eradication and one patient had persistence of wound infection after 8 days of sulbactam/ampicillin requiring surgical debridement. Two patients died after 3 days of therapy (one of the deaths was attributable to A. baumannii infection). The in-vitro activity of the sulbactam/ampicillin combination was by virtue of the antimicrobial activity exhibited by sulbactam. Killing curves showed that sulbactam was bacteriostatic; no synergy was observed between ampicillin and sulbactam. Our results indicate that sulbactam may prove effective for non-life-threatening A. baumannii infections. Its role in the treatment of severe infections is unknown. However, the current formulation of sulbactam alone may allow its use at higher doses and provide new potential synergic combinations, particularly for those infections by A. baumannii resistant to imipenem.  (+info)

Engineering a chimeric pyrroloquinoline quinone glucose dehydrogenase: improvement of EDTA tolerance, thermal stability and substrate specificity. (7/991)

An engineered Escherichia coli PQQ glucose dehydrogenase (PQQGDH) with improved enzymatic characteristics was constructed by substituting and combining the gene-encoding protein regions responsible for EDTA tolerance, thermal stability and substrate specificity. The protein region responsible for complete EDTA tolerance in Acinetobacter calcoaceticus, which is recognized as the indicator of high stability in co-factor binding, was elucidated. The region is located between 32 and 59% from the N-terminus of A. calcoaceticus PQQGDH(A27 region) and also corresponds to the same position from 32 to 59% from the N-terminus in E. coli PQQGDH, though E. coli PQQGDH is EDTA sensitive. We previously reported that the C-terminal 3% region of A. calcoaceticus (A3 region) played an important role in the increase of thermal stability, and that His775Asn substitution in E. coli PQQGDH resulted in an increase in the substrate specificity of E. coli PQQGDH towards glucose. Based on these findings, chimeric and/or mutated PQQGDHs, E97A3 H775N, E32A27E41 H782N, E32A27E38A3 and E32A27E38A3 H782N were constructed to investigate the compatibility of two protein regions and one amino acid substitution. His775 substitution to Asn corresponded to His782 substitution to Asn (H782N) in chimeric enzymes harbouring the A27 region. Since all the chimeric PQQGDHs harbouring the A27 region were EDTA tolerant, the A27 region was found to be compatible with the other region and substituted amino acid responsible for the improvement of enzymatic properties. The contribution of the A3 region to thermal stability complemented the decrease in the thermal stability due to the His775 or His782 substitution to Asn. E32A27E38A3 H782N, which harbours all the above mentioned three regions, showed improved EDTA tolerance, thermal stability and substrate specificity. These results suggested a strategy for the construction of a semi-artificial enzyme by substituting and combining the gene-encoding protein regions responsible for the improvement of enzyme characteristics. The characteristics of constructed chimeric PQQGDH are discussed based on the predicted model, beta-propeller structure.  (+info)

On the binding of ATP to the autophosphorylating protein, Ptk, of the bacterium Acinetobacter johnsonii. (8/991)

The autophosphorylating protein, Ptk, of the bacterium Acinetobacter johnsonii was overproduced, purified to homogeneity and assayed for ATP binding by using the nucleotide analog 5'-p-fluorosulfonylbenzoyl adenosine. The ATP binding site of this bacterial autophosphorylating protein was found to be different from that generally used by eukaryotic protein kinases. It consists of two amino acid sequences that closely resemble the Walker motifs A and B. This observation was confirmed by site-directed mutagenesis experiments which showed, in addition, that the ATP molecule bound to these motifs is effectively employed by the bacterial protein to autophosphorylate on tyrosine. It is concluded that even though the overall autophosphorylation reaction is similar in eukaryotic and prokaryotic proteins, the mechanism involved is likely different.  (+info)

TY - JOUR. T1 - Characterizing the regulation of the Pu promoter in Acinetobacter baylyi ADP1. AU - Huang, Wei E.. AU - Singer, Andrew C.. AU - Spiers, Andrew J.. AU - Preston, Gail M.. AU - Whiteley, Andrew S.. PY - 2008/7. Y1 - 2008/7. N2 - Effective gene trapping and screening requires sensory and regulatory compatibility of both host and exogenous systems. The naturally competent bacterium Acinetobacter baylyi ADP1 is able to efficiently take up and integrate exogenous DNA into the chromosome, making it an attractive host system for a wide range of metagenomic applications. To test the ability of A. baylyi ADP1 to express the XylR regulated Pu promoter from Pseudomonas putida mt-2, we have constructed and examined an A. baylyi ADP1 strain, ADPWH-Pu-lux-xylR. The Pu promoter in ADPWH-Pu-lux-xylR was specifically induced by toluene, m-, p- and o-xylene. The substrate induced Pu promoter was highly dependent on the growth medium: it was repressed in rich media until stationary phase, but was ...
Acinetobacter junii is a species of bacteria. Its type strain is ATCC 17908. It can be pathogenic. This bacterium has been linked to nosocomial infections including catheter-related blood stream infections and cellulitis. Vaneechoutte, M.; De Baere, T.; Nemec, A.; Musilek, M.; Van Der Reijden, T. J. K.; Dijkshoorn, L. (2008). Reclassification of Acinetobacter grimontii Carr et al. 2003 as a later synonym of Acinetobacter junii Bouvet and Grimont 1986. International Journal of Systematic and Evolutionary Microbiology. 58 (4): 937-940. doi:10.1099/ijs.0.65129-0. PMID 18398198. Bouvet, P. J. M.; Grimont, P. A. D. (1986). Taxonomy of the Genus Acinetobacter with the Recognition of Acinetobacter baumannii sp. nov., Acinetobacter haemolyticus sp. nov., Acinetobacter johnsonii sp. nov., and Acinetobacter junii sp. nov. and Emended Descriptions of Acinetobacter calcoaceticus and Acinetobacter lwoffii. International Journal of Systematic Bacteriology. 36 (2): 228-240. doi:10.1099/00207713-36-2-228. ...
TY - JOUR. T1 - Rapid detection of blaOXA in carbapenem-susceptible Acinetobacter radioresistens bacteremia leading to unnecessary antimicrobial administration. AU - Brady, Adam C.. AU - Lewis, James S.. AU - Pfeiffer, Christopher D.. N1 - Publisher Copyright: © 2016 Elsevier Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2016/8/1. Y1 - 2016/8/1. N2 - Rapid molecular techniques to identify resistant pathogens are revolutionizing antibiotic stewardship; however, it is important to recognize the limitations of these techniques. Herein we describe two cases of bacteremia that were both initially identified by genotypic testing as carbapenem-resistant Acinetobacter spp. and subsequently identified phenotypically as carbapenem-susceptible A. radioresistens. The genotypic results prompted unnecessary broad-spectrum antibiotic use and infection control concerns.. AB - Rapid molecular techniques to identify resistant pathogens are revolutionizing antibiotic stewardship; ...
The Acinetobacter radioresistens strain was isolated in our laboratories from an activated sludge pilot plant. It is able to grow in presence of either phenol or benzoate as the sole carbon and energy source, metabolizing them via the ortho pathway. A proteomic approach to the study of the regulation of these catabolic pathways showed that the expression of most of the catabolic enzymes is modulated by the growth substrate (1, 2). Moreover, satellite proteins were identified (porins, chaperonins), specifically induced by aromatics and probably involved in the uptake of these molecules and in the physiological cell response to their presence. In the present research these results have been extended by a more precise kinetic analysis of the bacterial growth on either an aromatic (phenol or benzoate) or a non-aromatic (acetate) carbon source. From these experiments it can be seen that cultures grown in presence of phenol or acetate show similar specific growth rates (=0.769 and 0.766 h-1 ...
Biohazard level, growth media and temperature, gram stain, industrial applications and more information for Acinetobacter radioresistens.
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Biosurfactant producers are crucial for incremental oil production in microbial enhanced oil recovery (MEOR) processes. The isolation of biosurfactant-producing bacteria from oil reservoirs is important because they are considered suitable for the extreme conditions of the reservoir. In this work, a novel biosurfactant-producing strain Acinetobacter junii BD was isolated from a reservoir to reduce surface tension and emulsify crude oil. The biosurfactants produced by the strain were purified and then identified via electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR-MS). The biosurfactants generated by the strain were concluded to be rhamnolipids, the dominant rhamnolipids were C26H48O9, C28H52O9 and C32H58O13. The optimal carbon source and nitrogen source for biomass and biosurfactant production were NaNO3 and soybean oil. The results showed that the content of acid components increased with the progress of crude oil biodegradation. A glass micromodel test
The highly variable nature of the internal transcribed spacer region (ITS) has been claimed to represent an ideal target for designing species-specific probes/primers capable of differentiating between closely related Acinetobacter species. However, several Acinetobacter species contain multiple ITS copies of variable lengths, and these include Acinetobacter bereziniae, Acinetobacter guillouiae and Acinetobacter baylyi. This study shows these length variations result from inter-genomic insertion/deletion events (indels) involving horizontal transfer of ITS fragments of other Acinetobacter species and possibly unrelated bacteria, as shown previously by us. In some instances, indel incorporation results in the loss of probe target sites in the recipient cell ITS. In other cases, some indel sequences contain target sites for probes designed from a single ITS sequence to target other Acinetobacter species. Hence, these can generate false positives. The largest of the indels that remove probe sites is 683 bp
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TY - JOUR. T1 - An Increase of Abundance and Transcriptional Activity for Acinetobacter junii Post Wastewater Treatment. AU - Jumat, Muhammad. AU - Haroon, Muhammad. AU - Aljassim, Nada I.. AU - Cheng, Hong. AU - Hong, Pei-Ying. N1 - KAUST Repository Item: Exported on 2021-02-19 Acknowledged KAUST grant number(s): BAS/1/1033-01-01 Acknowledgements: The authors would like to thank George Princeton Dunsford for access to the KAUST wastewater treatment plant and Moustapha Harb for providing sampling assistance. The research reported in this publication was supported by the KAUST baseline funding BAS/1/1033-01-01 awarded to Pei-Ying Hong.. PY - 2018/4/6. Y1 - 2018/4/6. N2 - A membrane bioreactor (MBR)-based wastewater treatment plant (WWTP) in Saudi Arabia is assessed over a five-month period in 2015 and once in 2017 for bacterial diversity and transcriptional activity using metagenomics, metatranscriptomics and real time quantitative polymerase chain reaction (RT-qPCR). Acinetobacter spp. are shown ...
Bacteria of the genus Acinetobacter are ubiquitous in nature. These organisms were invariably susceptible to many antibiotics in the 1970s. Since that time, acinetobacters; have emerged as multiresistant opportunistic nosocomial pathogens. The taxonomy of the genus Acinetobacter underwent extensive revision in the mid-1980s, and at least 32 named and unnamed species have now been described. Of these, Acinetobacter baumannii and the closely related unnamed genomic species 3 and 13 sensu Tjernberg and Ursing (13TU) are the most relevant clinically. Multiresistant strains of these species causing bacteraemia, pneumonia, meningitis, urinary tract infections and surgical wound infections have been isolated from hospitalised patients worldwide. This review provides an overview of the antimicrobial susceptibilities of Acinetobacter spp. in Europe, as well as the main mechanisms of antimicrobial resistance, and summarises the remaining treatment options for multiresistant Acinetobacter infections. © ...
Ver más] As a part of a nationwide study in Spain, 15 clinical isolates of Acinetobacter genomic species 3 (AG3) were analyzed. The main objective of the study was to characterize the ampC genes from these isolates and to determine their involvement in B-lactam resistance in AG3. The 15 AG3 isolates showed different profiles of resistance to ampicillin (range of MICs, 12 to ,256 μg/ml). Nucleotide sequencing of the 15 ampC genes yielded 12 new AmpC enzymes (ADC-12 to ADC-23). The 12 AG3 enzymes showed 93.7 to 96.1% amino acid identity with respect to the AmpC enzyme from Acinetobacter baumannii (ADC-1 enzyme). Eight out of fifteen ampC genes were expressed in Escherichia coli cells under the control of a common promoter, and with the exception of one isolate (isolate 65, which showed lower B-lactam MICs), significant differences in overall B-lactam MICs for E. coli cells expressing AG3 ampC genes were not revealed. No significant differences in ampC gene expression in AG3 clinical isolates ...
Optimum conditions for the activity of the new DNA methylase in cell lysate were determined. Methylation of DNAs of bacteriophages λ and T7 and plasmid pBR322 (dcm+) in the 5′-Cm5CWGG-3′ region blocked M.AjnI activity. The specificity of M.AjnI was determined using λ DNA methylated by this enzyme as well as computer modeling and data on the sensitivity of restriction endonucleases Mval, HinfI, and BstMAI to methylation.
COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Acinetobacter johnsonii ranks 2 on this scale: Species that can cause diseases in humans or animals, which are unlikely to spread in the human population and for which an adequate prophylaxis or therapy ...
การจำแนกเชื้อ Acinetobacter species สามารถใช้วิธี multiplex PCR เพื่อตรวจหา natural occurring blaOXA gene ที่จำเพาะต่อเชื้อแต่ละ species ได้ ดังนี้ blaOXA23 ในเชื้อ blaOXA134 ในเชื้อ A. lwoffii/A. schindleri, blaOXA211 ในเชื้อ A. johnsonii, blaOXA213 ในเชื้อ A. calcoaceticus, blaOXA214 ในเชื้อ A. haemolyticus, และ blaOXA228 ในเชื้อ A. bereziniae. ...
Three samples of terra rossa were shown to be efficient adsorbents of phosphate [P(V)] from wastewater and removed 29.9-32.6% of P(V). The total iron content in terra rossa was the key factor which determined the P(V) removal from wastewater. The original samples of terra rossa were effective support materials for the immobilization of metabolically active P(V)-accumulating bacteria Acinetobacter junii (0.56-2.47×1010 CFU g-1). The removal of oxalate-extractable iron from original sample of terra rossa increased the number of immobilized bacteria to 1.34×1011 CFU g-1, which is the largest number of immobilized bacteria reported in the literature so far. In reactors containing the A. junii and terra rossa P(V) was removed from wastewater by simultaneous adsorption onto terra rossa and accumulation inside bacterial cells, resulting in 40.5-62.5% of P(V) removal. Terra rossa is a promising substrate for biological P(V) removal from wastewater, acting both as adsorbent of P(V) and carrier of ...
The SOS response to DNA damage that induces up to 10% of the prokaryotic genome requires RecA action to relieve LexA transcriptional repression. In Acinetobacter species, which lack LexA, the error-prone polymerase accessory UmuDAb is instead required for ddrR induction after DNA damage, suggesting it might be a LexA analog. RNA-Seq experiments defined the DNA damage transcriptome (mitomycin C-induced) of wild type, recA and umuDAb mutant strains of both A. baylyi ADP1 and A. baumannii ATCC 17978. Of the typical SOS response genes, few were differentially regulated in these species; many were repressed or absent. A striking 38.4% of all ADP1 genes, and 11.4% of all 17978 genes, were repressed under these conditions. In A. baylyi ADP1, 66 genes (2.0% of the genome), including a CRISPR/Cas system, were DNA damageinduced, and belonged to four regulons defined by differential use of recA and umuDAb. In A. baumannii ATCC 17978, however, induction of 99% of the 152 mitomycin C-induced genes depended on recA,
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Strategy for In Situ Detection of Natural Transformation-Based Horizontal Gene Transfer Events - they used a pUC derived plasmid called pCLT that they got from Palmen and Hellingwerf ...
After 30 d incubation, the NA experiment showed removal effi ciency of 6.8% only (5,017 to 4,848 mg kg−1) as shown in Table 3. NA appears ineffective in removal of the bio-recalcitrant fraction C18-C22, containing the non-volatile hydrocarbons with indigenous bacteria (102 CFU g−1). Soil washing by spraying sterile water without disturbing the soil in the Ctrl experiment showed that 11.2% of the hydrocarbons were removed from the soil (Fig. 2(b)). Wu et al. [28] have shown a similar pattern of removal rate (16%) of TPH when sterile water was added to soil. Water tends to flush out hydrocarbons and other contaminants from soil [36]. In the BIO microcosms, there was no marked difference in degradation until 15 d of incubation (Table 3). A notable increase in degradation rate was observed after 15 d, and resulted in 56.4% of C18-C22 hydrocarbons being removed by the end of the experiment, which The initial concentration of hydrocarbons was 5,202 mg kg−1. Values represent average of triplicate ...
Acinetobacter sp. ATCC ® 49467D™ Designation: Genomic DNA from Acinetobacter sp. strain AmMS 248 TypeStrain=False Application:
1EO2: Structure of Acinetobacter strain ADP1 protocatechuate 3, 4-dioxygenase at 2.2 A resolution: implications for the mechanism of an intradiol dioxygenase.
1EOC: Structure of Acinetobacter strain ADP1 protocatechuate 3, 4-dioxygenase at 2.2 A resolution: implications for the mechanism of an intradiol dioxygenase.
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Based on imipenem resistance in an Acinetobacter genospecies 3 clinical isolate, we were able to identify, for the first time in this genomic species, a plasmid-encoded blaOXA-58 gene that was 100% homologous to the same ...
The World Health Organization has just released its list of the 12 bacteria that pose the greatest risk to humanitys existence, stating that new antibiotics are urgently needed to counter them. WHO held a press conference recently to unveil the list of the most dangerous superbugs, which are resistant to most antibiotics making them difficult or nearly impossible to treat.. The bacteria Acinetobacter baumannii topped the list. This disease can result in pneumonia, blood infections, and more. It affects people with compromised immune systems, and it attacks organ systems with a high fluid content, like the respiratory or urinary tract. ...
Microbial taxonomy remains a conservative discipline, relying on phenotypic information derived from growth in pure culture and techniques that are time-consuming and difficult to standardize, particularly when compared to the ease of modern high-throughput genome sequencing. Here, drawing on th ...
Acinetobacter sp. ATCC ® 49137™ Designation: AmMS 203 TypeStrain=False Application: Quality control strain Quality control strain for MicroScan [Reg TM] products
Domain architectures containing the following SCOP superfamilies _gap_,52518,52518,52922,_gap_ in Acinetobacter sp. ADP1. Domain architectures illustrate each occurrence of _gap_,52518,52518,52922,_gap_.
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Acinetobacter calcoaceticus is a bacterial species of the genus Acinetobacter. It is a nonmotile, gram negative coccobacillus. It grows under aerobic conditions, is catalase positive and oxidase negative. It is part of the normal human intestinal flora. Together with A. baumannii, it is referred to as the A. calcoaceticus-A. baumannii complex, which is relatively simple to identify based on the beforementioned phenotypic characteristics. To identify other Acinetobacter species genotyping is required. A. calcoaceticus is a soil bacterium. It has been shown to be prevalent in the tiger mosquito Aedes albopictus microflora. Phloroglucinol carboxylic acid is a degradation product excreted by A. calcoaceticus grown on (+)-catechin as the sole source of carbon. A. calcoaceticus can be pathogenic and cause an opportunistic infection in patients with multiple underlying diseases. A. calcoaceticus can be used as an alternative to A. baumannii in the laboratory setting. The interchangeability of the two ...
Wax ester synthases (WSs) can synthesize wax esters from alcohols and fatty acyl coenzyme A thioesters. The knowledge of the preferred substrates for each WS allows the use of yeast cells for the production of wax esters that are high-value materials and can be used in a variety of industrial applications. The products of WSs include fatty acid ethyl esters, which can be directly used as biodiesel. Here, heterologous WSs derived from five different organisms were successfully expressed and evaluated for their substrate preference in Saccharomyces cerevisiae. We investigated the potential of the different WSs for biodiesel (that is, fatty acid ethyl esters) production in S. cerevisiae. All investigated WSs, from Acinetobacter baylyi ADP1, Marinobacter hydrocarbonoclasticus DSM 8798, Rhodococcus opacus PD630, Mus musculus C57BL/6 and Psychrobacter arcticus 273-4, have different substrate specificities, but they can all lead to the formation of biodiesel. The best biodiesel producing strain was found to be
Bacteria of the genus Acinetobacter, with their numerous species common in various habitats, play a significant role as pathogens. Their ability to adapt to different living conditions is largely due to the presence of numerous plasmids containing the necessary adaptive genes. At the same time the diversity of Acinetobacter plasmids and their evolutionary dynamics have not been sufficiently studied. Here, we characterized 44 plasmids isolated from five permafrost Acinetobacter lwoffii strains, examined their relationship with plasmids of modern Acinetobacter strains and identified groups of related plasmids. For this purpose, we have developed a combined approach for classifying all known Acinetobacter plasmids. The classification took into account the size of plasmids, the presence and structure of the rep and mob genes, as well as the structure of their backbone and accessory regions. Based on the analysis, 19 major groups (lineages) of plasmids were identified, of which more than half were small
Acinetobacter calcoaceticus MopR protein: Member of the NtrC family of transcriptional activators with significant homology to XylR and DmpR from Pseudomonas; regulates phenol degradation in Acinetobacter calcoaceticus; has ATP-binding activity; binds phenol; GenBank CAA93242
Acinetobacter Infections - Pipeline Review, H1 2017 Summary Latest Pharmaceutical and Healthcare disease pipeline guide Acinetobacter Infections - Pipeline
Teck Wee Boo, Molecular characterisation of carbapenem resistance of Acinetobacter species in an Irish tertiary care hospital, [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2010, pp 377 ...
Genus and Species: Acinetobacter calcoaceticus (strepomycin sensitive) Domain: Prokaryote Optimal Growth Medium: Brain Heart Infusion Agar Optimal Growth Temperature: 30° C Package: MicroKwik Culture® Vial Biosafety Level: 2 Gram Stain: Gram-Negative Shape: Bacillus (rod-shaped)
Domain architecture and assignment details (superfamily, family, region, evalue) for HMPREF0012_00695T0 from Acinetobacter calcoaceticus ruh2202. Plus protein sequence and external database links.
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Complementing our current clinical pipeline, we have three additional drug candidates in preclinical development. AR-501 has broad bactericidal activity against Gram-negative and Gram-positive bacteria, including antibiotic-resistant strains. AR-201 is a human IgG1 mAb directed against the F-protein of respiratory syncytial virus (RSV). AR-401 is a mAb discovery program to treat infections caused by the Gram-negative bacterium Acinetobacter baumannii.. ...
I am interested in DNA repair mechanisms and recombination. These processes are essential for the protection of organisms from DNA-damaging agents such as ultraviolet light and chemical mutagens. These mechanisms also contribute to the evolution of new traits. Projects in my lab involve using genetic and molecular techniques to study DNA repair and recombination in the bacteria Escherichia coli and Acinetobacter baylyi. In E. coli, DNA damage causes the induction of over 20 genes and this is termed the SOS response. Although the SOS system has served as a model for understanding DNA repair and recombination in other systems such as yeast, plants and humans, there is still much that we dont understand about the SOS response in E. coli. For example, we have not yet identified the precise inducing signal of the SOS response or the biological functions of many of the SOS gene products. It is not yet clear whether A. baylyi exhibits an E. coli-like SOS response. Characterization of DNA repair and ...
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By Stewart MacInnis. Spectrum Volume 18 Issue 21 - February 22, 1996 John L. Johnson, whose pioneering research on differential Bacteroides species won him international recognition as a microbiologist, died last Friday (Feb. 16) at his Blacksburg home after a long illness. He was 59.. He was an outstanding scientist, he was an excellent teacher, and he really cared about his work, said W.E.C. Moore, a friend and former colleague of Johnsons. The world lost a top scientist in microbiology.. Moore, then head of the anaerobe laboratory, brought Johnson to Virginia Tech from his post-doctoral studies at the University of Washington-Seattle in 1968. John did his best work here, Moore said.. That work earned Johnson the 1980 Bergeys Manual Trust Award, one of the most prestigious international awards given in his field. The Pasteur Institute of Paris named a bacterial species for Johnson, Acinetobacter johnsonii. That, Moore said, is a sign of exceptional respect and an indication of the ...
Resistência aos antibióticos β-lactâmicos em isolados clínicos de Acinetobacter spp : caracterização molecular de novas carbapenemases, IMP-5 e OXA-33, e estudo da relação clonal entre os isolados resistentes ao ...
SUMMARY Steel and Cowan (1964) designated Schaub's Biol. 1 as the type strain for Bacterium anitratum Schaub and Hauber 1948. However, this strain was not included among those originally studied by Schaub and Hauber (1948) and cannot be recognized (Rule 9d, Note b, Intl. Code of Nomenclature of Bacteria). One of the original strains used by Schaub and Hauber (Schaub 81, American Type Culture Collection (ATCC) 19606, RH 2208) is here designated as the type for B. anitratum Schaub and Hauber 1948. The morphology, physiology, and per cent guanine plus cytosine of strain 81 are described and more than sixty characters of the strain recorded. The characteristics of strain 81 were found to be in good agreement with those given in the original description by Schaub and Hauber (1948).
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Inovatívny kočík Mima Zigi vyniká svojim elegantným dizajnom, kompaktnou veľkosťou a dôrazom na detaily zjednodušujúce váš každodenný život s malým dieťaťom.Kočík zložíte veľmi ľahko jednou rukou do samostatne stojaceho kompaktného tvaru, zodpovedajúceho veľkosti palubnej batožiny väčšiny leteckých spoločností.Kolesá s dokonalým odpružením sú extrémne odolné a ľahké a zaručujú hladkú jazdu. Predné otočné kolesá s možnosťou aretácie zaisťujú jednoduché manévrovanie s kočíkom.Strieška kočíka je vybavená originálnym automatickým systémom skladania, vďaka ktorému zloženiu aj rozloženie striešky vykonáte jedným pohybom zápästia. Ochranu dieťaťa pred škodlivým slnečným žiarením zaisťujú dve slnečné clony s UV filtrom. Okienko v strieške vám uľahčí kontrolu dieťaťa v kočíku počas jazdy a zároveň umožňuje vetranie kočíka počas horúcich letných dní.Opierku chrbta je možné nastaviť do 3 polôh ...
Accepted name: 2-hydroxycyclohexanone 2-monooxygenase. Reaction: 2-hydroxycyclohexan-1-one + NADPH + H+ + O2 = 6-hydroxyhexan-6-olide + NADP+ + H2O. Systematic name: 2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing). Comment: the product decomposes spontaneously to 6-oxohexanoic acid (adipic semialdehyde).. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 62628-31-3. References. 1. Davey, J.F. and Trudgill, P.W. The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species. Eur. J. Biochem. 74 (1977) 115-127. [PMID: 856571]. ...
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Xanthomonas spp., Argobacterium spp., Acinetobacter spp., Corynebacterium spp., Bacteroides spp., Clostridium spp., ...
Acinetobacter sp. shows both quorum sensing and quorum quenching activity. It produces AHLs and also, it can degrade the AHL ... It has recently been found that Acinetobacter sp. also show quorum sensing activity. This bacterium, an emerging pathogen, ... Co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia". BMC Microbiology. 11 (1): 51. doi: ... Co-existence of Quorum Quenching and Quorum Sensing in Acinetobacter and Burkholderia". BMC Microbiology. 11 (1): 51. doi: ...
Acinetobacter baumanii; Epidemiology of Highly Pathogenic Microorganisms; Epidemiological Modelling of Infectious Diseases; ...
Towner K J (2008). "Molecular Basis of Antibiotic Resistance in Acinetobacter spp.". Acinetobacter Molecular Biology. Caister ... Reis AO, Luz DA, Tognim MC, Sader HS, Gales AC (2003). "Polymyxin-Resistant Acinetobacter spp. Isolates: What Is Next?". Emerg ... These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter. It comes in a form which ... Use of colistin to treat Acinetobacter baumannii infections has led to the development of resistant bacterial strains. which ...
Acinetobacter resistente a multidrogas[editar , editar a fonte]. Acinetobacter é unha baceria gramnegativa que causa pneumonía ... "Medscape abstract on Acinetobacter baumannii: Acinetobacter baumannii: An Emerging Multidrug-resistant Threat". membership only ... Acinetobacter baumannii[editar , editar a fonte]. En 2004, os Centros para o Control de Enfermidades e Prevención (CDC) de EUA ... O Acinetobacter resistente a multifármacos fíxose moi resistente aos antibióticos.[15] Campylobacter resistente a fármacos[ ...
Acinetobacter species • Aeromonas hydrophila • Bacillus brevis • Bacillus Cereus • Bacillus megaterium • Bacillus subtilis • ...
Acinetobacter johnsonii Frequent occasionally pathogenic Pseudomonas aeruginosa Infrequent occasionally pathogenic Fungal[edit] ...
Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ...
Multiple Sclerosis and Acinetobacter calcoaceticus). His findings have been cited by proponents of herbal medicine Low-starch ...
In addition to Pseudomas, Acinetobacter sp. SYF26 was isolated from the Hei He reservoir in China. Genomic analysis revealed a ... Acinetobacter sp. SYF26". Microbiology. 161 (4): 829-837. doi:10.1099/mic.0.000047. PMID 25667009. S2CID 206197998. Takaya, ...
Acinetobacter species are able to survive on various surfaces (both moist and dry) in the hospital environment, thereby being ... In addition, Acinetobacter is uniquely suited to exploitation for biotechnological purposes. Gamma-150 RNA motif, a unique RNA ... The genus Acinetobacter is a group of Gram-negative, nonmotile and nonfermentative bacteria belonging to the family ... A few members are opportunistic pathogens, such as species of Pseudomonas, Moraxella, and Acinetobacter, which may cause ...
"НПО "Биомед" разрабатывает препарат бактериофага против Acinetobacter , РИА Новости". 2011-10-06. Retrieved 2014-08-13 ... the company received the first samples of bacteriophage preparation against the pathogen Acinetobacter, which is the causative ...
Duine JA, Frank J, van Zeeland JK (1979). "Glucose dehydrogenase from Acinetobacter calcoaceticus: a 'quinoprotein'". FEBS Lett ...
Matsushita K, Shinagawa E, Adachi O, Ameyama M (July 1989). "Quinoprotein D-glucose dehydrogenase of the Acinetobacter ... Geiger O, Gorisch H (1986). "Crystalline quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus". Biochemistry. 25 ... "Cloning of the gene encoding quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus: evidence for the presence of ... "Soluble and membrane-bound quinoprotein D-glucose dehydrogenases of the Acinetobacter calcoaceticus : the binding process of ...
Duine JA, Frank J, van Zeeland JK (December 1979). "Glucose dehydrogenase from Acinetobacter calcoaceticus: a 'quinoprotein'". ...
... used to kill Acinetobacter and Legionella species; this drug is limited by high cost and risk of liver injury Alosetron - used ...
Antunes LC, Imperi F, Carattoli A, Visca P (2011). Adler B (ed.). "Deciphering the Multifactorial Nature of Acinetobacter ...
Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74 (1 ... Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1-7. doi ...
Morgan RD, Dalton M, Stote R (September 1987). "A unique type II restriction endonuclease from Acinetobacter lwoffi N". Nucleic ... a new restriction endonuclease from Acinetobacter calcoaceticus". Nucleic Acids Res. 13 (24): 8685-94. doi:10.1093/nar/13.24. ... a new restriction endonuclease from Acinetobacter calcoaceticus recognizing 5'-AA^CGTT-3'". Nucleic Acids Res. 20 (14): 3787. ... a novel restriction endonuclease from Acinetobacter calcoaceticus BS (Article in russian)". Prikl Biokhim Mikrobiol. 33 (5): ...
Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1-7. doi ...
Among bacteria, degradation of (+)-catechin can be achieved by Acinetobacter calcoaceticus. Catechin is metabolized to ... catechin by Acinetobacter calcoaceticus MTC 127". Biochimica et Biophysica Acta (BBA) - General Subjects. 1621 (3): 261-265. ...
In a 1982 study by Devaud et al., a multi-drug resistant strain of Acinetobacter was isolated and examined. Evidence pointed to ... Devaud, M; Kayser, FH; Bächi, B (Aug 1982). "Transposon-mediated multiple antibiotic resistance in Acinetobacter strains". ...
"Green synthesis of selenium nanoparticles using Acinetobacter sp. SW30: Optimization, characterization and its anticancer ...
"Deciphering the Multifactorial Nature of Acinetobacter baumannii Pathogenicity". PLOS ONE. 6 (8): e22674. Bibcode:2011PLoSO... ...
Acinetobacter radioresistens strain AIMST Nalbe6 16S ribosomal RNA gene, partial sequence. NCBI. Acinetobacter soli strain ... Acinetobacter calcoaceticus strain AIMST Nalbe4 16S ribosomal RNA gene, partial sequence. NCBI. Acinetobacter calcoaceticus ... Acinetobacter calcoaceticus strain AIMST Ngme3 16S ribosomal RNA gene, partial sequence. NCBI. Acinetobacter calcoaceticus ... Acinetobacter radioresistens strain AIMST Nalbe6 (N. alba; Mount Jerai, Kedah, Malaysia; leaf tissue) Acinetobacter soli strain ...
"Medscape abstract on Acinetobacter baumannii: Acinetobacter baumannii: An Emerging Multidrug-resistant Threat". membership only ... Acinetobacter is a gram-negative bacteria that causes pneumonia or bloodstream infections in critically ill patients. Multidrug ... On November 5, 2004, the Centers for Disease Control and Prevention (CDC) reported an increasing number of Acinetobacter ... Centers for Disease Control Prevention (CDC). (2004). "Acinetobacter baumannii infections among patients at military medical ...
Acinetobacter strains may grow on solid media as coccobacilli. Bordetella pertussis is a Gram-negative coccobacillus ...
Acinetobacter strains may grow on solid media as coccobacilli. Coxiella burnetti is also a coccobacillus. Spiral bacteria are ...
Patel RN, Hou CT, Felix A, Lillard MO (July 1976). "Catechol 1,2-dioxygenase from Acinetobacter calcoaceticus: purification and ... Acinetobacter calcoaceticus, Trichosporon cutaneum, Rhodococcus erythropolis, Frateuria sp., Rhizobium trifolii, Pseudomonas ...
Retrieved from "" ...
Vernacular names [edit wikidata Category:Acinetobacter linked to current category] [edit wikidata Acinetobacter main topic ... NCBI link: Acinetobacter Brisou & Prevot 1954 *World Register of Marine Species link: Acinetobacter Brisou & Prevot, 1954 (+ ... Media in category "Acinetobacter". The following 3 files are in this category, out of 3 total. ... Structure of Catechol 1,2-dioxygenase from Acinetobacter Calcoaceticus Native Data.jpg 500 × 500; 48 KB. ...
Acinetobacter baumannii is one of the most frequently isolated bacteria in the ICU but significant regional differences exist. ... Acinetobacter baumannii is a gram-negative aerobic bacillus that primarily causes hospital-acquired infections affecting ... Purpose of review: We reviewed recent data about epidemiology of Acinetobacter baumannii, resistance mechanisms, and ...
Acinetobacter is a group of germs that can cause infections in the blood, urinary tract and pneumonia, typically in patients in ... Acinetobacter is a group of bacteria (germs) commonly found in the environment, like in soil and water. While there are many ... Acinetobacter baumannii can cause infections in the blood, urinary tract, and lungs (pneumonia), or in wounds in other parts of ... What is CDC doing to address Acinetobacter infections?. CDC tracks the germ, and the infections it can cause, through its ...
Bacteria of the Acinetobacter ACB complex, which are frequently acquired in hospital settings, can also be found in beef meat, ... The antibiotic-resistant Acinetobacter baumannii bacterium is one of the most globally harmful bacteria that causes nosocomial ... Antibiotic-resistant Acinetobacter baumannii infections, one of the most common hospital-acquired infections in children across ... In the first national study of the prevalence of antibiotic-resistant Acinetobacter baumannii infections in children across the ...
Acinetobacter baumannii is a pleomorphic aerobic gram-negative bacillus (similar in appearance to Haemophilus influenzae on ... encoded search term (Acinetobacter) and Acinetobacter What to Read Next on Medscape. Medscape Consult. ... Acinetobacter activity, and their use may predispose to Acinetobacter colonization. Some strains are sensitive to cefepime, ... Clonal spread of Acinetobacter baumannii in a general intensive care unit. Ann Ig. 2004 Jan-Apr. 16(1-2):95-102. [Medline]. ...
Acinetobacter definition at, a free online dictionary with pronunciation, synonyms and translation. Look it up ... acinetobacter. noun. *a bacterium that causes infections such as pneumonia, particularly in people who have a compromised ... acinetobacter. C20: from Greek acetinae immovable + bacter (ium). Collins English Dictionary - Complete & Unabridged 2012 ...
Rather than being a single type of bacterium Acinetobacter is made up of over 25 varieties. ... Acinetobacter bacteria are present in water, soil and sewage. ... Acinetobacter: A Look at Bad Bacteria. Acinetobacter bacteria ... Treating Acinetobacter Bacteria. The difficulty that medical personnel have when an Acinetobacter infection occurs is that it ... Symptoms of Acinetobacter Bacteria Infection. A person who has become infected with Acinetobacter bacteria may develop ...
Acinetobacter baumannii is a pleomorphic aerobic gram-negative bacillus (similar in appearance to Haemophilus influenzae on ... encoded search term (Acinetobacter) and Acinetobacter What to Read Next on Medscape. Related Conditions and Diseases. * ... The most common infection-causing species is A baumannii, followed by Acinetobactercalcoaceticus and Acinetobacterlwoffii. [1] ... Acinetobacter commonly colonizes patients in the intensive care setting. Acinetobacter colonization is particularly common in ...
Acinetobacter baumannii is the cause of difficult-to-treat infections in healthcare settings in Europe due to its increasing ...
... Kim et al. 2014. ›Acinetobacter sp. HYN18. ›JCM 18575. ›KACC 16906. ›strain HYN18. ...
Acinetobacter baumanni. ›Acinetobacter baumannii Bouvet and Grimont 1986. ›Acinetobacter genomosp. 2. More ». ›Acinetobacter ... Acinetobacter. › Acinetobacter calcoaceticus/baumannii complex. Strains i. › 252. › ATCC 17945 / CIP 70.22. › ATCC 17961 / CIP ... Acinetobacter sp. NCTC 7422. ›Bacterium anitratum. ›CCUG 19096. ›CIP 70.34. ›DSM 30007. ›JCM 6841. ›LMG 1041. ›LMG:1041. ›NCCB ...
Acinetobacter is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria. Acinetobacter species ... In healthy individuals, Acinetobacter colonies on the skin correlate with low incidence of allergies; Acinetobacter is thought ... The genus Acinetobacter comprises 38 validly named species. Identification of Acinetobacter species is complicated by lack of ... Alliance for the Prudent Use of Antibiotics Acinetobacter sp. ADP1 Genome Page CycSim: metabolic model of Acinetobacter baylyi ...
Acinetobacter is a bacteria that is becoming difficult to treat due to its resistance to antibiotics. Utah Bureau of ... Acinetobacter. Acinetobacter have become one of the most difficult bacteria to treat. The species, A. baumannii, can cause ... These infections are referred to as carbapenem-resistant Acinetobacter (CRAB) infections.. These bacteria are most often spread ...
Your basket is currently empty. i ,p>When browsing through different UniProt proteins, you can use the basket to save them, so that you can back to find or analyse them later.,p>,a href=/help/basket target=_top>More...,/a>,/p> ...
Acinetobacter pragensis is a bacterium from the genus of Acinetobacter which occurs in soil and water. Parte, A.C. " ... "Acinetobacter". LPSN. "Acinetobacter pragensis". Parker, Charles Thomas; Garrity, George M (1 January 2003). ... Type strain of Acinetobacter pragensis at BacDive - the Bacterial Diversity Metadatabase v t e. ... Radolfova-Krizova, L; Maixnerova, M; Nemec, A (October 2016). "Acinetobacter pragensis sp. nov., found in soil and water ...
ATCC ® 49467D™ Designation: Genomic DNA from Acinetobacter sp. strain AmMS 248 TypeStrain=False Application: ... Acinetobacter sp. (ATCC® 49467D™) Strain Designations: Genomic DNA from Acinetobacter sp. strain AmMS 248 [ATCC® 49467™] / Type ... Genomic DNA from Acinetobacter sp. strain AmMS 248 [ATCC® 49467™] Biosafety Level 1 Biosafety classification is based on U.S. ...
... Designation: S2 TypeStrain=False Application: Assay of cefoperazone Assay of sulbactam ... Acinetobacter baumannii (ATCC® 43498™) Strain Designations: S2 / Type Strain: no / Biosafety Level: 2 ...
... Designation: AmMS 203 TypeStrain=False Application: Quality control strain Quality control ... Acinetobacter sp. (ATCC® 49137™) Strain Designations: AmMS 203 / Type Strain: no / Biosafety Level: 2 ...
... Designation: AmMS 203 TypeStrain=False Application: Quality control strain Quality control ...
Each antibiotic is presented in three columns. The first column lists the name of the antibiotic. The middle column represents susceptibility in percent to that antibiotic. The 3rd column represents the number of isolates tested for that specific antibiotic ...
Patients with Acinetobacter pneumonias occurring in the context of an outbreak in the intensive care unit (IC... more ... Prolonged hospitalization or antibiotic therapy predisposes to Acinetobacter colonization. ... Drugs & Diseases , Infectious Diseases , Acinetobacter Q&A Which clinical history findings are characteristic of Acinetobacter ... Prolonged hospitalization or antibiotic therapy predisposes to Acinetobacter colonization.. Patients with Acinetobacter ...
Acinetobacter Brisou et Prévot 1954, in "Bergeys Manual of Systematic Bacteriology, vol.1," p.303, N.R. Grieg and J.G. Holt, ... Members of the genus Acinetobacter can frequently be isolated from healthy people and are also commonly present in soil and ... Poh, C.L., and Loh, G.K., 1985, Enzymatic profile of clinical isolates of Acinetobacter calcoaceticus, Med. Microbiol. Immunol. ... Avril JL., Mesnard R. (1991) Factors Influencing the Virulence of Acinetobacter. In: Towner K.J., Bergogne-Bérézin E., Fewson C ...
Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis.. Jacobs AC1, Hood I, Boyd KL, Olson PD, ... Acinetobacter baumannii is an emerging bacterial pathogen of considerable health care concern. Nonetheless, relatively little ...
This volume serves researchers studying the Gram-negative bacterium Acinetobacter baumannii with chapters detailing ... Acinetobacter baumannii. Methods and Protocols Editors: Biswas, Indranil, Rather, Philip N. (Eds.) ... Authoritative and cutting-edge, Acinetobacter baumannii: Methods and Protocols aims to ensure successful results in the further ... Assessing Acinetobacter baumannii Virulence and Persistence in a Murine Model of Lung Infection ...
Isolation of tetD, tetC, tetB, tetA‎ genes from Acinetobacter bummani samples isolated from hospital samples by multiplex PCR ... The Frequency of blaPER، blaVEB، blaCTX-M، tetA and tetB genes among Acinetobacter baumannii strains isolated from hospitalizes ... Assessment of Frequency and antibiotic resistance pattern of Acinetobacter spp. isolated from traumatic patients in Shahid ... Probiotics in Goat Milk: A Promising Solution for Management of Drug-Resistant Acinetobacter baumannii ...
Retrieved from "" ...
Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 percent of the rooms of patients ... Acinetobacter baumannii is a species of gram-negative, multidrug resistant bacteria that has caused outbreaks of infection in ... Washington, DC, November 1, 2011 -- Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 ... the study did not evaluate healthcare worker or patient movement and therefore cannot demonstrate transmission of Acinetobacter ...
Gutnick D. Potential Application of Acinetobacter in Biotechnology in Acinetobacter Molecular Biology. Gerischer U (editor), ... In healthy humans, it is normal to have some amount of Acinetobacter on the skin surface; as many as 25% of healthy adults do ... Acinetobacter cells are Gram-negative short rods (coccobacilli), measuring 1.0-1.5 by 1.5-2.5 microns during growth; they often ... Acinetobacter. Houston Medical School, University of Texas. 1995.. Herper, Matthew. The Iraq Infection., August 2 ...
What does acinetobacter mean? A genus of aerobic, gram-negative bacteria occurring primarily in soil and water, including many ... Acinetobacter meaning. ă′sə-nē′tō-băk ′ tər, -nĕt′ō-, -nē ′ tō-băk′-, nĕt ′ ō- ...
  • Because routine identification in the clinical microbiology laboratory is not yet possible, Acinetobacter isolates are divided and grouped into three main complexes: Acinetobacter calcoaceticus-baumannii complex: glucose-oxidising nonhemolytic (A. baumannii can be identified by OXA-51 typing) Acinetobacter lwoffii: glucose-negative nonhemolytic Acinetobacter haemolyticus: hemolytic Different species of bacteria in this genus can be identified using fluorescence-lactose-denitrification to find the amount of acid produced by metabolism of glucose. (
  • Most Acinetobacter isolates recovered from hospitalized patients, particularly those recovered from respiratory secretions and urine, represent colonization rather than infection. (
  • The presence of Acinetobacter isolates in respiratory secretions in intubated patients may represent colonization. (
  • Up to 27% of hospital sink traps and 20% of hospital floor swabs have yielded isolates of Acinetobacter . (
  • The objectives of this study were to study the presence of mutators in a set of Acinetobacter baumannii isolates and to explore whether there is a correlation between mutation rates and antibiotic resistance. (
  • Using data from 300 hospitals around the country, this analysis looked at 47,415 Acinetobacter species isolates and their susceptibility against imipenem over the period 1999 to 2006. (
  • Acinetobacter are still generally described as nonmotile, but most isolates exhibit 'otwitching' motility. (
  • The characteristics of carbapenem heteroresistance were studied in 14 apparently carbapenem-susceptible Acinetobacter baumannii isolates. (
  • In a study of blood stream infections (BSI) from 52 US hospitals from 1995 to 2003, Acinetobacter species were the 10th most frequently isolated pathogen accounting for 1.3% of all BSI, of which A. baumannii accounted for two-thirds of the isolates. (
  • From the Danube river water, 262 Acinetobacter were isolated, the most common species was Acinetobacter baumannii with 135 isolates. (
  • The population of Acinetobacter ( baumannii and non -baumannii ) revealed a significant proportion of human-generated antibiotic resistance and multiresistance, but the majority of the isolates stayed susceptible to most of the tested antibiotics. (
  • Okasha, H. and Meheissen, M. (2017) In Vitro Activity of Colistin and Vancomycin or Azithromycin Combinations on Extensively Drug Resistant Acinetobacter baumannii Clinical Isolates. (
  • Acinetobacter is a group of bacteria (germs) commonly found in the environment, like in soil and water. (
  • Bacteria of the Acinetobacter ACB complex, which are frequently acquired in hospital settings, can also be found in beef meat, according to a study led by ISGlobal, an institution supported by "la Caixa" and performed with meat samples from markets in Lima, Peru. (
  • The antibiotic-resistant Acinetobacter baumannii bacterium is one of the most globally harmful bacteria that causes nosocomial infections. (
  • Acinetobacter is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria. (
  • Bacteria of the genus Acinetobacter are known to form intracellular inclusions of polyhydroxyalkanoates under certain environmental conditions (e.g. lack of elements such as phosphorus, nitrogen, or oxygen combined with an excessive supply of carbon sources). (
  • Acinetobacter bacteria are fairly common microbes that can be found in many parts of the environment. (
  • Acinetobacter bacteria can be an issue for people who have been admitted to hospital. (
  • A person who has become infected with Acinetobacter bacteria may develop pneumonia-like symptoms. (
  • Staff that come into contact with patients infected with Acinetobacter bacteria are encouraged to wear gloves and gowns to reduce the risk of spreading the infection. (
  • Acinetobacter have become one of the most difficult bacteria to treat. (
  • Acinetobacter baumannii is a species of gram-negative, multidrug resistant bacteria that has caused outbreaks of infection in healthcare facilities over the last decade and considerable concern in the medical community. (
  • it is the last test which is most used to distinguish Acinetobacter from other infective bacteria. (
  • Acinetobacters are widely distributed in hospitals, where they pose the danger of transferring resistance to other hospital-inhabiting bacteria. (
  • Bacteria of the genus Acinetobacter , with their numerous species common in various habitats, play a significant role as pathogens. (
  • In 1954, Brisou and PrA(c)vot proposed the genus Acinetobacter to indicate that the bacteria were nonmotile because they lacked flagella. (
  • Acinetobacter baumannii bacteria is known to cause pneumonia or serious blood or wound infections. (
  • Acinetobacter species are gram-negative, non-fermenting, often coccobacillary bacteria that belong in the family Moraxellaceae. (
  • Acinetobacter baumannii bacteria, coloured scanning electron micrograph (SEM). (
  • Multi-drug resistant Acinetobacter baumannii bacteria inside biofilm, computer illustration. (
  • Acinetobacter infection , also known as Acinetobacter Baumannii Infection, is caused by the Acinetobacter baumannii bacteria . (
  • Acinetobacter infection is a highly contagious disease caused by the Acinetobacter baumannii bacteria. (
  • Bacteria of the Acinetobacter genus. (
  • Background: Extensively drug resistant Acinetobacter baumannii (XDR-AB) presents an increasing challenge to health care in Egypt as they are among the most common bacteria isolated in hospital setting. (
  • Acinetobacter baumannii: Infection control implications. (
  • Acinetobacter species are a key source of infection in debilitated patients in the hospital, in particular the species Acinetobacter baumannii. (
  • The morphology of Acinetobacter species can be quite variable in Gram-stained human clinical specimens, and cannot be used to differentiate Acinetobacter from other common causes of infection. (
  • The difficulty that medical personnel have when an Acinetobacter infection occurs is that it can be resistant to antibiotics. (
  • For example, a number of soldiers who were involved Operation Iraqi Freedom and Operation Enduring Freedom developed an Acinetobacter infection that was multidrug resistant. (
  • The most common infection-causing species is A baumannii, followed by Acinetobacter calcoaceticus and Acinetobacter lwoffii . (
  • Acinetobacter species have low virulence but are capable of causing infection in organ transplants and febrile neutropenia. (
  • Multiple factors tend to increase the risk for acquiring an Acinetobacter infection, including prior antibiotic exposure, intensive care unit admission, use of a central venous catheter, and mechanical ventilation or hemodialysis use. (
  • When Acinetobacter causes actual infection, the pathological changes that occur depend on the organ system involved. (
  • Although Acinetobacter is primarily a colonizer in the hospital environment, it occasionally causes infection. (
  • Acinetobacter infection has no known racial predilection. (
  • Which clinical history findings are characteristic of Acinetobacter infection? (
  • Nosocomial respiratory tract infection and colonization with Acinetobacter calcoaceticus. (
  • An outbreak of Acinetobacter respiratory tract infection resulting from incomplete disinfection of ventilatory equipment. (
  • Washington, DC, November 1, 2011 -- Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 percent of the rooms of patients colonized or infected with the pathogen, according to a new study published in the November issue of the American Journal of Infection Control , the official publication of APIC - the Association for Professionals in Infection Control and Epidemiology. (
  • Because Acinetobacters are very resistant to antibiotics and are difficult to differentiate between species when isolated from patients, learning more about their DNA will help develop better drugs to control outbreaks of the infection. (
  • The authors conclude that discussions of disease control ought to consider resistant Acinetobacter a high priority and point to the need for a comprehensive solution to the problem of antibiotic resistance to address this growing public health threat, such as more rigorous infection control on a regional basis. (
  • Following the child's death, the state Department of Health also discovered four cases of Acinetobacter baumannii infection in the NICU of the hospital since October. (
  • Wade said that acinetobacter is a hospital-acquired infection with no community transmission, which means that it does not pose risk of spreading in the Newark community. (
  • Diagnosis of infection was based on CDC criteria plus the isolation of Acinetobacter from a usually sterile site or from broncoalvelolar lavage. (
  • However, whether cefepime-cefpirome can be used to treat an Acinetobacter bloodstream infection (BSI) if it is active against the causative pathogen(s) is not clear. (
  • Acinetobacter junii has been isolated from aerators of water faucets contaminated from an outbreak of this bacterium which is found ubiquitously in nature thus, no common source of infection might be defined. (
  • Of these 81 cases, Acinetobacter infection was found in 13 cases. (
  • The preferred anti-infective agents for serious, invasive Acinetobacter infection is a carbapenem. (
  • Carbapenem-resistant Acinetobacter baumannii (CRAB) causes health care-associated infections that are challenging to contain and often linked to infection prevention and control (IPC) breaches. (
  • Acinetobacter baumannii infection is highly contagious. (
  • Anyone can get an Acinetobacter baumannii infection. (
  • You are more likely to get an infection from Acinetobacter baumannii if you have a disease such as diabetes or chronic obstructive pulmonary disease (COPD). (
  • An Acinetobacter baumannii infection can cause serious damage in the lungs, blood, and brain. (
  • Acinetobacter baumannii colonizes the respiratory tract, skin, urinary and gastrointestinal systems, and frequently leads to pneumonia, blood circulatory infection, and urinary system infection. (
  • An Acinetobacter baumannii infection can cause serious damage to the lungs, blood, and brain. (
  • Multidrug-resistant Acinetobacter baumannii (MDR-AB) was found in the environment of 48 percent of the rooms of patients colonized or infected with the pathogen, according to a new study published in the November issue of the American Journal of Infection Control. (
  • Body lice that fed on rabbits infused with each Acinetobacter species demonstrated a generalized infection. (
  • Ecological aspects and prophylaxis of Acinetobacter baumannii nosocomial infection. (
  • All efforts must be expended to prevent a hospital acquired MDR Acinetobacter infection. (
  • Acinetobacter species are oxidase-negative, exhibit twitching motility, and occur in pairs under magnification. (
  • Species of the genus Acinetobacter are strictly aerobic, nonfermentative, Gram-negative bacilli. (
  • The genus Acinetobacter comprises 38 validly named species. (
  • Identification of Acinetobacter species is complicated by lack of standard identification techniques. (
  • This method allowed identification of A. calcoaceticus-A. baumannii complex by the formation of smooth, rounded, mucoid colonies at 37 °C. Closely related species could not be differentiated and individual species such as A. baumannii and Acinetobacter genomic species 3 could not be positively identified phenotypically. (
  • Acinetobacter species are widely distributed in nature, and commonly occur in soil and water. (
  • Their ability to survive on moist and dry surfaces, as well as to survive exposure to various common disinfectants, allows some Acinetobacter species to survive in a hospital environment. (
  • Furthermore, Acinetobacter species can grow at a broad range of temperatures, allowing them to survive in a broad array of environments. (
  • The Acinetobacter has more than 50 species, most of which are nonpathogenic environmental organisms. (
  • Acinetobacter species are can be transmitted to patients because of their persistence on environmental surfaces and because of colonization of the hands of healthcare workers. (
  • Update on acinetobacter species: mechanisms of antimicrobial resistance and contemporary in vitro activity of minocycline and other treatment options. (
  • Although only one species, A. calcoaceticus , is described in the latest edition of Bergey's Manual of Systematic Bacteriology (Juni, 1984) the taxonomy of Acinetobacter has recently been extensively revised (Grimont and Bouvet, this volume). (
  • A. baumannii is now the most prevalent Acinetobacter species isolated from clinical specimens, but for historical reasons this review will refer to Acinetobacter without detailed consideration of individual species. (
  • Acinetobacter is a genus of opportunistic pathogens in the proteobacteria group, species of which are distributed in widespread, diverse habitats. (
  • It has garnered media attention because of an outbreak among soldiers in Iraq who contracted the species Acinetobacter baumannii . (
  • Blood culture grew Acinetobacter species. (
  • Members of the genus Acinetobacter are ubiquitous in the environment and the multiple-drug resistant species A. baumannii is of significant clinical concern. (
  • It has garnered media attention because of an outbreak among soldiers in Iraq who contracted the species Acinetobacter baumannii from the Iraqi soil. (
  • While there are many types or species of Acinetobacter and all can cause human disease, Acinetobacter baumannii accounts for about 80% of reported infections. (
  •   Respiratory Bacterial infections due to Acinetobacter species are typically encountered in health care settings and can be particularly difficult to treat due to the propensity of the organism to incorporate multiple antibiotic resistance mechanisms. (
  • Acinetobacter species are widely distributed in nature and the hospital environment and can survive on moist and dry surfaces, and may be present in foodstuffs and on healthy skin. (
  • Since it remains unclear how to treat bacteremia caused by AB, the present study aims to enroll patients at multiple sites with extensively drug resistant Acinetobacter species bacteremia receiving different combination therapy to assess treatment outcomes and analyze risk factors associated with mortality. (
  • Blood sample will be collected on the day of enrollment (Day 0), Day 1, 2, 3 and 7 for PCR identification and quantification of Acinetobacter species. (
  • The lice excreted living Acinetobacter species within their feces. (
  • Acinetobacter species as a cause of catheter-related infections. (
  • Distribution of Acinetobacter species on skin of healthy humans. (
  • Over the past four years MDR Acinetobacter and Pan-resistant Acinetobacter species have been showing up in patients referred to our facility. (
  • We reviewed recent data about epidemiology of Acinetobacter baumannii , resistance mechanisms, and therapeutic options for severe infections caused by multidrug-resistant strains. (
  • Most strains of Acinetobacter, except some of the A. lwoffii strain, grow well on MacConkey agar (without salt). (
  • Acinetobacter strains are often ubiquitous, exhibit metabolic versatility, are robust and some provide convenient systems for modern molecular genetic manipulation and subsequent product engineering. (
  • Here, we characterized 44 plasmids isolated from five permafrost Acinetobacter lwoffii strains, examined their relationship with plasmids of modern Acinetobacter strains and identified groups of related plasmids. (
  • In laboratory experiments, we compared the abilities of five Acinetobacter baumannii strains, three Acinetobacter sp. (
  • Of the 13 implicated Acinetobacter strains, A. baumannii was the most common (12), and the other was A. lwoffii (1). (
  • Here, we describe two plasmids carrying mcr-4.3 in two Acinetobacter baumannii strains isolated from imported food and a clinical sample. (
  • The presence of human generated multidrug resistant strains is well documented but the extent to how widely they are distributed within the Acinetobacter population is unknown. (
  • Clonally related strains of Acinetobacter that differ in susceptibility patterns may coexist within a single hospital, dependent on the selective pressure related to antibiotic exposure. (
  • Nosocomial infections have become alarming with the increase of multidrug resistant bacterial strains of Acinetobacter baumannii. (
  • Growth on the AMA indicates a positive transformation assay and confirms the isolate as a member of the genus Acinetobacter. (
  • Acinetobacter pragensis is a bacterium from the genus of Acinetobacter which occurs in soil and water. (
  • Members of the genus Acinetobacter can frequently be isolated from healthy people and are also commonly present in soil and water as free-living saprophytes. (
  • Any bacterium of the genus Acinetobacter . (
  • Therefore, the A1S_2225 gene, which is present in several members of the Acinetobacter genus, was named b lue- l ight- s ensing A ( blsA ). (
  • Acinetobacter baumannii is an emerging bacterial pathogen of considerable health care concern. (
  • But a different pathogen, Acinetobacter baumannii, is an expanding threat and controlling outbreaks of it are proving extremely difficult, said the study, published in the British medical journal The Lancet. (
  • Acinetobacter baumannii is an opportunistic pathogen operating in hospitals creating serious infections such as pneumonia. (
  • The drug development pipeline includes several agents with encouraging in vitro activity against Acinetobacter , but their place in therapy and contribution to the armamentarium against this pathogen remain to be defined. (
  • The objective of this review is to highlight the unique challenge of treating infections due to Acinetobacter and summarize recent literature regarding optimal antimicrobial treatment for this pathogen. (
  • Acinetobacter baumannii is an opportunistic pathogen and is a problem in the hospital setting in US and Europe. (
  • Acinetobacter radioresistens is rarely a human pathogen. (
  • A dangerous pathogen, Acinetobacter , is growing more resistant to antibiotics and increasingly common in U.S. hospitals. (
  • Acinetobacter baumannii is an opportunistic bacterial pathogen which causes infections in immunosuppressed patients. (
  • Acinetobacter baumannii -named in honor of American bacteriologists Paul and Linda Baumann-is a nosocomial pathogen with acquired multidrug resistance that is emerging as a major concern worldwide. (
  • Acinetobacter baumannii is an opportunistic pathogen associated with severe hospital infections ( 1 , 16 ), which often need the use of carbapenems as the treatment of last resort. (
  • Carbapenem-resistant Acinetobacter baumannii (CRAB), an opportunistic pathogen primarily associated with hospital-acquired infections, is an urgent public health threat ( 1 ). (
  • In this work, we show that the opportunistic pathogen Acinetobacter baumannii senses and responds to blue light. (
  • Acinetobacter baumannii has emerged as an opportunistic pathogen among acutely ill patients, especially those with thermal injury. (
  • Here we provide evidence that DHA, an omega-3 fatty acid, has superior antimicrobial effects upon the highly drug-resistant pathogen Acinetobacter baumannii , thereby providing insights into one of the potential health benefits of omega-3 fatty acids. (
  • Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones. (
  • Acinetobacter baumannii has emerged as a pan-drug-resistant pathogen and displays a remarkable ability to persist in hospital settings despite desiccation and antimicrobial treatment. (
  • The Food and Drug Administration (FDA) is announcing this public workshop regarding the current state and further development of animal models for serious infections caused by Acinetobacter baumanii and Pseudomonas aeruginosa . (
  • Acinetobacter baumannii has been designated as one of the six ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas and Enterobacter) bacterial pathogens of greatest healthcare concern. (
  • Garnacho-Montero J, Amaya-Villar R. Multiresistant Acinetobacter baumannii infections: epidemiology and management. (
  • Outbreak of a multiply resistant Acinetobacter in a surgical intensive care unit: epidemiology and control. (
  • The Epidemiology of Multidrug-Resistant Acinetobacter Baumannii Does the Community Represent a Reservoir? (
  • Acinetobacter baumannii is a gram-negative aerobic bacillus that primarily causes hospital-acquired infections affecting specially to debilitated patients with prolonged hospitalization and with long-term exposition to antimicrobials. (
  • Acinetobacter baumannii is a pleomorphic aerobic gram-negative bacillus (similar in appearance to Haemophilus influenzae on Gram stain) commonly isolated from the hospital environment and hospitalized patients. (
  • Similarly, Acinetobacter urinary tract infections are clinically indistinguishable from catheter-associated bacteremias caused by other aerobic gram-negative bacilli. (
  • Acinetobacter baumannii is a Gram-negative bacterium that is associated with hospital-acquired and ventilator-associated pneumonia. (
  • Adult Acinetobacter meningitis and its comparison with non-Acinetobacter gram-negative bacterial meningitis. (
  • Clinical and laboratory data of these Acinetobacter meningitis patients were studied and were compared with those of other 68 non-Acinetobacter Gram-negative bacterial meningitis (GNBM) patients. (
  • Gram-negative bacterium Acinetobacter baumannii. (
  • MDR Acinetobacter is an organism resistant to two of the five classes of drugs generally effective against gram negative organism and Pan-resistant Acinetobacter is resistant to all antibiotics. (
  • A group in the Department of Immunology, Microbiology and Parasitology at the UPV/EHU has conducted an in-depth study into the capacity to survive of the Acinetobacter baumannii bacterium as well as the strategies it uses to survive. (
  • Rather than being a single type of bacterium Acinetobacter is made up of over 25 varieties. (
  • Acinetobacter baumannii can cause infections in the blood, urinary tract, and lungs (pneumonia), or in wounds in other parts of the body. (
  • The 2005 IDSA guidelines for hospital-acquired pneumonia discuss the role of Acinetobacter as a cause of nosocomial pneumonia. (
  • New research finds curcumin combined with a polyphenol in green tea and other foods and herbs will inhibit multi-drug resistant Acinetobacter baumannii - often at the root of hospital-acquried pneumonia infections. (
  • Acinetobacter community acquired pneumonia. (
  • Community-acquired bacteraemic Acinetobacter pneumonia with survival. (
  • Acinetobacter is a rare potentially fatal cause of community-acquired pneumonia. (
  • Community-acquired Acinetobacter pneumonia: a case report. (
  • Share information about any additional Acinetobacter platelet bacterial contamination cases being investigated. (
  • Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A . mBio, Vol. 9, Issue. (
  • In one of the largest studies to measure the burden of antibiotic resistance in a low- or middle-income country, researchers at the Center for Disease Dynamics, Economics & Policy report that in-hospital mortality is significantly higher among patients infected with multi-drug resistant or extensively drug resistant pathogens including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii. (
  • Describe the clinical course of four patients who experienced sepsis after transfusion of apheresis platelets contaminated with Acinetobacter calcoaceticus-baumannii and Staphylococcus saprophyticus . (
  • In this program, the speakers will review four cases of septic transfusion reactions from apheresis platelets contaminated with Acinetobacter calcoaceticus-baumanni (and also Staphylococcus saprophyticus) which were recently reported in an MMWR. (
  • Acinetobacter infections are generally treated with antibiotics. (
  • Unfortunately, many Acinetobacter germs are resistant to many antibiotics, including carbapenems, which makes them difficult to treat with available antibiotics. (
  • Patients with Acinetobacter colonization often have a history of prolonged hospitalization or antimicrobial therapy (with antibiotics that have little or no activity against Acinetobacter ). (
  • 4-Hydroxybenzaldehyde (4-HBA), which cannot support the growth of Acinetobacter baumannii , exhibited synergism only with amphenicol antibiotics including chloramphenicol (CAM) and thiamphenicol. (
  • Damier-Piolle L, Magnet S, Bremont S, Lambert T, Courvalin P (2008) AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii . (
  • Impact of multi-drug-resistant Acinetobacter baumannii on clinical outcomes. (
  • Treatment of infections caused by multi-drug resistant Acinetobacter spp. (
  • In this assay, a naturally competent tryptophan auxotrophic mutant of Acinetobacter baylyi (BD4 trpE27) is transformed with the total DNA of a putative Acinetobacter isolate and the transformation mixture is plated on a brain heart infusion agar. (
  • Molecular characterization of the gene encoding a new AmpC ß-lactamase in Acinetobacter baylyi - ADP1 has a chromosomal copy of AmpC? (
  • An experimental approach to this question was presented by the heat-sensitive phenotype conferred by pcaG1102 , a 30-bp deletion in one of the structural genes for Acinetobacter baylyi protocatechuate 3,4-dioxygenase, which is required for growth with quinate. (
  • The interplay between contrasting forces, i.e., loss of DNA by sequence-guided deletion against maintenance of sequence repetition for useful function, was illustrated by genetic investigation of pcaO , the operator that governs transcription of the pca - qui operon in Acinetobacter baylyi strain ADP1. (
  • Unfortunately, over the past years there has been a worldwide increase in infections caused by carbapenem-resistant Acinetobacter. (
  • We performed a retrospective review of the case records of patients from 1996 to 2004 who had nosocomial infections caused by carbapenem-resistant Acinetobacter spp. (
  • Neonakis IK, Spandidos DA, Petinaki E. Confronting multidrug-resistant Acinetobacter baumannii: a review. (
  • Optimal therapy for multidrug-resistant Acinetobacter baumannii. (
  • Treatment of nosocomial meningitis due to a multidrug resistant Acinetobacter baumannii with intraventricular colistin. (
  • Acinetobacter pneumonias occur in outbreaks and are usually associated with colonized respiratory-support equipment or fluids. (
  • The circumstances of some outbreaks demonstrated the long survival of Acinetobacter in a dry, inanimate environment. (
  • Outbreaks of carbapenem-resistant Acinetobacter baumannii in healthcare facilities have been reported in Europe and worldwide. (
  • Hospital outbreaks of multidrug-resistant Acinetobacter infections have been reported. (
  • In general, first-, second-, and third-generation cephalosporins, macrolides, and penicillins have little or no anti- Acinetobacter activity, and their use may predispose to Acinetobacter colonization. (
  • Acinetobacter colonization is particularly common in patients who are intubated and in those who have multiple intravenous lines or monitoring devices, surgical drains, or indwelling urinary catheters. (
  • Prolonged hospitalization or antibiotic therapy predisposes to Acinetobacter colonization. (
  • In the first national study of the prevalence of antibiotic-resistant Acinetobacter baumannii infections in children across the US, researchers from Center for Disease Dynamics, Economics, & Policy (CDDEP) in Washington, DC and Rush University in Chicago, IL examined national and regional trends of antibiotic resistance in clinical specimens over a 13-year period. (
  • Acinetobacter baumannii is the cause of difficult-to-treat infections in healthcare settings in Europe due to its increasing resistance to antimicrobial agents, in particular the carbapenems. (
  • Assessment of Frequency and antibiotic resistance pattern of Acinetobacter spp. (
  • Acinetobacter remains one of the most challenging pathogens in the field of infectious diseases owing primarily to the uniqueness and multiplicity of its resistance mechanisms. (
  • This resistance often leads to devastatingly long delays in time to appropriate therapy and increased mortality for patients afflicted with Acinetobacter infections. (
  • Of these resistant organisms, Acinetobacter remains one of the most formidable opponents, as its unique and eclectic resistance mechanisms allow it to escape the activity of the majority of our currently available antimicrobials. (
  • Although there is already a high resistance baseline in some countries, there has been an overall increase of carbapenem-resistant Acinetobacter baumannii in Europe. (
  • A statistically significant difference between Acinetobacter meningitis and non-Acinetobacter GNBM included hydrocephalus and ceftazidime-resistance. (
  • Antibiotic resistance is a major problem with Acinetobacter infections. (
  • A novel, plasmid-mediated, high-level tigecycline resistance tet (X) gene variant, tet (X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. (
  • Antibiotic Resistance of Acinetobacter spp. (
  • The genetic background of carbapenem resistance was mostly based on typical Acinetobacter OXA enzymes but also on VIM-2. (
  • Zarfel, G.E. Antibiotic Resistance of Acinetobacter spp. (
  • Coyne S, Rosenfeld N, Lambert T, Courvalin P, Perichon B (2010) Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii . (
  • Antibiotic resistance in Acinetobacter baumannii is a major global health threat. (
  • Meropenem Breakpoints for Acinetobacter spp. (
  • This rationale document summarizes the data used by CLSI in 2013 to support the current meropenem breakpoints for Acinetobacter spp. (
  • Carbapenems, including meropenem, are currently considered the first-line agents for the treatment of infections caused by Acinetobacter spp. (
  • Antimicrobial Susceptibility Testing Methods for Acinetobacter spp. (
  • Selecting appropriate empiric and definitive antibacterial therapy for Acinetobacter is further complicated by the lack of reliability in commercial antimicrobial susceptibility testing devices and limited breakpoint interpretations for available agents. (
  • Pharmacokinetic considerations regarding tigecycline for multidrug-resistant (MDR) Klebsiella pneumoniae or MDR Acinetobacter baumannii urosepsis. (
  • Antibiotic-resistant Acinetobacter baumannii infections, one of the most common hospital-acquired infections in children across the United States, are on the rise, according to results of a recent study published in the Journal of the Pediatric Infectious Diseases Society on March 22. (
  • Antibiotic-resistant Acinetobacter meningitis in neurosurgical patients. (
  • When Acinetobacter infections occur, they usually involve organ systems that have a high fluid content (eg, respiratory tract, CSF, peritoneal fluid, urinary tract). (
  • Patients with Acinetobacter pneumonias occurring in the context of an outbreak in the intensive care unit (ICU) generally have a history of preceding contact with respiratory support monitors or equipment. (
  • In spite of an increasing number of reports that Acinetobacter induces respiratory and urinary tract infections and septicaemia (Bergogne-Bérézin et al. (
  • An important feature of Acinetobacter is also the presence of multiple plasmids in the same strain. (
  • The emergence of Acinetobacter infections in adult post-neurosurgical infections, multiple antibiotic resistant characteristics, and the emergence of PDRAB strain remained a challenge of the initial management of this specific meningitis. (
  • Complete Genome Sequence of Acinetobacter indicus Type Strain SGAir0564 Isolated from Tropical Air Collected in Singapore. (
  • A strain of Acinetobacter baumannii 6B92 isolated from the blood culture of a patient at the Edinburgh Royal Infirmary i 1985 was found to be resistant to imipenem, all classes of cephalosporins and penicillins. (
  • Carbapenem-resistant Acinetobacter are usually multidrug-resistant. (
  • In 2017, carbapenem-resistant Acinetobacter caused an estimated 8,500 infections in hospitalized patients and 700 estimated deaths in the United States [ Source: 2019 AR Threats Report ]. (
  • These infections are referred to as carbapenem-resistant Acinetobacter (CRAB) infections. (
  • Diante da escassez de dados sobre o assunto, estudos que avaliem o tratamento de infecções por Acinetobacter spp resistente a carbapenem são necessários. (
  • A 4-year surveillance of carbapenem-resistant Acinetobacter spp. (
  • Previous studies have reported the isolation of Acinetobacter baumannii from the body lice of homeless patients. (
  • Isolation of Acinetobacter spp. (
  • Any patient who has MDR Acinetobacter must be room confined to a hospital room for their entire stay with isolation precautions to prevent spread to the other vulnerable patient populations. (
  • Survival of Acinetobacter baumannii on dry surfaces. (
  • Acinetobacter baumannii causes a wide range of nosocomial infections. (
  • Many of the characteristics of Acinetobacter ecology, taxonomy, physiology and genetics point to the possibility of exploiting its unique features for future applications. (
  • There was a more than 300 percent increase in the proportion of Acinetobacter cases resistant to the antibiotic imipenem during 1999 to 2006. (
  • pI 9.0) and a novel beta-lactomase of pI 6.65 named ARI 1 (Acinetobacter resistant to imipenem). (
  • Antimicrobials drugs frequently reported as active against Acinetobacter spp include carbapenems, colistin, ampicillin/sulbactam, amikacin, rifampin and tetracyclines and currently carbapenens are considered the main antimicrobial treatment. (
  • With MDR Acinetobacter there is often only one drug, colistin, which this organism is sensitive to. (
  • Acinetobacter junii is associated with nosocomial pathogens including pediatric oncologic individual and bacteremia in preterm infants. (
  • Acinetobacter Brisou et Prévot 1954, in "Bergey's Manual of Systematic Bacteriology, vol.1," p.303, N.R. Grieg and J.G. Holt, eds. (
  • Neurosurgically related nosocomial Acinetobacter baumannii meningitis: report of two cases and literature review. (
  • Genome sequencing revealed that most were Acinetobacter baumannii , whereas seven represented other Acinetobacter spp. (