Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Chemistry Techniques, Synthetic: Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs.Posters as Topic: Single or multi-sheet notices made to attract attention to events, activities, causes, goods, or services. They are for display, usually in a public place and are chiefly pictorial.Organic Chemistry Processes: The reactions, changes in structure and composition, the properties of the reactions of carbon compounds, and the associated energy changes.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Caffeic Acids: A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.Phenylethyl Alcohol: An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.Quantitative Structure-Activity Relationship: A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.Propolis: A resinous substance obtained from beehives that is used traditionally as an antimicrobial. It is a heterogeneous mixture of many substances.Chlorogenic Acid: A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).EstersMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Coumaric Acids: Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.Lipoxygenases: Dioxygenases that catalyze the peroxidation of methylene-interrupted UNSATURATED FATTY ACIDS.Halogens: A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Triazenes: Compounds with three contiguous nitrogen atoms in linear format, H2N-N=NH, and hydrocarbyl derivatives.Bombax: A plant genus of the family BOMBACACEAE. The fine silky hairs covering the seeds have been used like kapok (CEIBA) for floatation, stuffing, and insulation.Dacarbazine: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)Ergothioneine: A naturally occurring metabolite of HISTIDINE that has antioxidant properties.Benzene DerivativesImidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.Tamarindus: A plant genus of the family FABACEAE known for its sour fruit.Social Media: Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.Advertising as Topic: The act or practice of calling public attention to a product, service, need, etc., especially by paid announcements in newspapers, magazines, on radio, or on television. (Random House Unabridged Dictionary, 2d ed)Xylans: Polysaccharides consisting of xylose units.Candy: Sweet food products combining cane or beet sugars with other carbohydrates and chocolate, milk, eggs, and various flavorings. In the United States, candy refers to both sugar- and cocoa-based confections and is differentiated from sweetened baked goods; elsewhere the terms sugar confectionary, chocolate confectionary, and flour confectionary (meaning goods such as cakes and pastries) are used.Poly A: A group of adenine ribonucleotides in which the phosphate residues of each adenine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.Blogging: Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.Glucans: Polysaccharides composed of repeating glucose units. They can consist of branched or unbranched chains in any linkages.Social Behavior: Any behavior caused by or affecting another individual, usually of the same species.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Coated Materials, Biocompatible: Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Phospholipid Ethers: Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)Particle Size: Relating to the size of solids.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)Hyperlipidemia, Familial Combined: A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Hyperlipidemias: Conditions with excess LIPIDS in the blood.Animal Shells: The hard rigid covering of animals including MOLLUSCS; TURTLES; INSECTS; and crustaceans.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)PhthalazinesAldehyde Oxidase: An aldehyde oxidoreductase expressed predominantly in the LIVER; LUNGS; and KIDNEY. It catalyzes the oxidation of a variety of organic aldehydes and N-heterocyclic compounds to CARBOXYLIC ACIDS, and also oxidizes quinoline and pyridine derivatives. The enzyme utilizes molybdenum cofactor and FAD as cofactors.BenzaldehydesPoly(ADP-ribose) Polymerases: Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.Poly Adenosine Diphosphate Ribose: A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
(1/8) Studies on tellurium-containing heterocycles. Part 20. Reactions of 2-benzoselenopyrylium salts and 2-benzotelluropyrylium salts with nucleophiles: formation of 1-functionalized 1H-isoselenochromenes and 1H-isotellurochromenes.

The reactions of the 2-benzoselenopyrylium (1A) and 2-benzotelluropyrylium cations (1B) with a variety of nucleophiles have been investigated. LiAlH(4), sodium alkoxide (NaOMe, NaOi-Pr and NaOt-Bu), diethylamine, n-butylamine and acetone reacted with 1 to give the 1H-isochromenes (2) and the corresponding 1-substituted products (4-9) under mild conditions in almost good to high yields. The 1-alkyl(phenyl)isoselenochromenes (10-13) and 1-benzylisochromenes (18A, 18B), which were produced by the reaction of the salts 1 with Grignard reagents, were converted to the corresponding 1,3-disubstituted 2-benzopyrylium salts (14-17, 19) by treatment with triphenylcarbenium tetrafluoroborate (Ph(3)C(+) BF(4)(-)), respectively. The 1-benzylselenopyrylium salts (19A) and 1-benzyltelluropyrylium salts (19B) exist in the solvent as an equilibrium mixture of the salts (19) and the corresponding (Z)-benzylidene compounds (20).  (+info)

(2/8) Highly regioselective palladium-catalyzed annulation reactions of heteroatom-substituted allenes for synthesis of condensed heterocycles.

We have developed a highly regioselective synthesis of heterocycles via palladium-catalyzed annulation reaction of heteroatom-substituted allenes. Various aryl halides were reacted and one regioisomer was observed exclusively in all reactions. In addition, subsequent functionalizations of annulated products were carried out using alkyl metal reagents, and the introduction of alkyl moieties was accomplished.  (+info)

(3/8) Experimental and theoretical studies on the functionalization reactions of 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid and acid chloride with 2,3-diaminopyridine.

The 1H-pyrazole-3-carboxylic acid 2 was converted in good yield (69%) into the corresponding 1H-pyrazole-3-carboxamide 5 via reaction of the acid chloride 3 with 2,3- diaminopyridine (4). A different product, the 3H-imidazo[4,5-b] pyridine derivative 6, was formed from the reaction of 3 with 4 and base in benzene for 5 hours. The structures of the synthesized compounds were determined spectroscopically. The mechanism of the reaction between 3 and 4 was examined theoretically.  (+info)

(4/8) Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells.

 (+info)

(5/8) Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses.

 (+info)

(6/8) Radioiodination of aryl-alkyl cyclic sulfates.

 (+info)

(7/8) Stimulating beta-cell regeneration by combining a GPR119 agonist with a DPP-IV inhibitor.

 (+info)

(8/8) Synthesis, electrochemistry, and photophysics of a family of phlorin macrocycles that display cooperative fluoride binding.

 (+info)

*  Porphyrin
... aromatic amino acids, and nucleic acid heterocyclic bases, to produce oxidative radicals that damage the cell, possibly ... acetic acid, and propionic acid are typical reaction solvents, or p-toluenesulfonic acid or various Lewis acids can be used ... by the reaction of the amino acid glycine with succinyl-CoA from the citric acid cycle. In plants, algae, bacteria (except for ... Simplified view of heme, a complex of a protoporphyrin IX.]] Porphyrins are the conjugate acids of ligands that bind metals to ...
*  Chelidonic acid
... is a heterocyclic organic acid with a pyran skeleton. Chelidonic acid can be prepared in two steps from diethyl ... Dimethyl oxalate Dehydroacetic acid E. Raymond Riegel and F. Zwilgmeyer (1937). "Chelidonic acid". Organic Syntheses. 17: 40 ... Chelidonic acid was first discovered in extracts of Chelidonium majus. It occurs naturally in plants of the Asparagales order. ... See also: Lerch, Joseph Udo (1846) "Untersuchung der Chelidonsäure" (Investigation of chelidonic acid), Annalen der Chemie und ...
*  Orotic acid
... is a heterocyclic compound and an acid; it is also known as pyrimidinecarboxylic acid. Historically it was believed ... Orotic acid can be mutagenic in mammalian somatic cells. It is also mutagenic for bacteria and yeast. A buildup of orotic acid ... This also leads to an increased urinary orotic acid excretion, because the orotic acid is not being properly utilized and must ... Lippincott (2008). Biochemistry (4th ed.). Orotic acid MSDS Orotic Acid at the US National Library of Medicine Medical Subject ...
*  Isonipecotic acid
... is a heterocyclic compound which acts as a GABAA receptor partial agonist. It consists of a piperidine ring ... with a carboxylic acid moiety in the iso position (and as such is also known as "4-piperidinecarboxylic acid"). Mortensen M, ...
*  Organolead compound
... types of aryl and vinyl organoleads are transmetalation for instance with boronic acids and acid-catalyzed heterocyclic ... For instance anisole with lead tetraacetate forms 'p-methoxyphenyllead triacetate in chloroform and dichloroacetic acid: Other ...
*  Tolmetin
... /ˈtɒlmətɪn/ is a nonsteroidal anti-inflammatory drug (NSAID) of the heterocyclic acetic acid derivative class. It is ...
*  Citrazinic acid
... is a heterocyclic compound consisting of a dihydropyridine ring derived from citric acid. The yellow solid ... Citrazinic acid is very sparingly soluble in water, acid and methanol but is soluble in basic solutions (e.g. ammonia water). ...
*  Uric acid
As a bicyclic, heterocyclic purine derivative, uric acid does not protonate from an oxygen (−OH) as carboxylic acids do. X-ray ... Uric acid levels in saliva may be associated with blood uric acid levels. Hyperuricemia (high levels of uric acid), which ... It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic ... Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. ...
*  Biotin
... is a heterocyclic, S-containing monocarboxylic acid. It is made from two precursors, alanine and pimeloyl-CoA via three ... A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme for ... 7,8Diaminopelargonic acid (DAPA) aminotransferase is unusual in using S-adenosyl methionine (SAM) as the NH2 donor. ... 8-Amino-7-oxopelargonic acid synthase is a pyridoxal 5'-phosphate enzyme. The pimeloyl-CoA, could be produced by a modified ...
*  2-Furoic acid
... is a heterocyclic carboxylic acid, consisting of a five-membered aromatic ring and a carboxylic acid group. Its ... 2-furoic acid may have an important role in the field of optic technology. Studies concerning the preparation of 2-furoic acid ... 2-furoic acid helps sterilize and pasteurize many foods. The main mechanism that produces the 2-furoic acid for food ... The salts and esters of furoic acids are known as furoates. 2-Furoic acid is an organic compound most widely found in food ...
*  Codinaeopsin
... module and results in the central heterocyclic tetramic acid (2,4-pyrrolidinone). The formal oxidation-reduction is found to be ...
*  Pudovik reaction
Ali, Tarik E.; Abdel-Kariem, Somaia M. (2015). "Methods for the synthesis of α-heterocyclic/heteroaryl-α-aminophosphonic acids ... 1952). "Новый метод синтеза сс-аминофосфиновых кислот" [A new method for the synthesis of α-amino phosphoric acids]. Doklady ... Fields, Ellis K. (1952). "The synthesis of esters of substituted amino phosphonic acids". Journal of the American Chemical ...
*  Ketorolac
... in the family of heterocyclic acetic acid derivatives, used as an analgesic. It is considered a first-generation NSAID. ...
*  Petasis reaction
Apart from vinyl boronic acids, aryl boronic acids and other heterocyclic derivatives can also be used in Petasis ... In α-amino acid synthesis, α-keto acids, such as glyoxylic and pyruvic acid, are stirred in ethanol, toluene, or ... Synthesis of amino acids β,γ-unsaturated, N-substituted amino acids are conveniently prepared through the condensation of ... When certain chiral amines, such as (S)-2-phenylglycinol, are mixed with an α-keto acid and vinyl boronic acid at room ...
*  Khristo Ivanov
The resulting new derivatives of 3-acylaminopropanoic acids were transformed into various heterocyclic compounds: beta-lactams ... It is used for elaboration of preparative methods for conversion of nitriles, esters and amides of coumarin-3-carboxylic acid ... A new interesting rearrangement of 3-substituted coumarins to 2-oxochromans-4-acetic acid derivatives was found for the first ... Reactions of 3-acyl-substituted 2H-1-benzopyran-2-ones with acid anhydrides, II. 1991, Liebigs Annalen der Chemie, (12), pp. ...
*  Grilling
Heterocyclic amines (HCAs) are formed when amino acids, sugars, and creatine react at high temperatures. Polycyclic aromatic ... Sugimura, Takashi; Wakabayashi, Keiji; Nakagama, Hitoshi; Nagao, Minako (April 2004). "Heterocyclic amines: Mutagens/ ... and fish at high temperatures can lead to the formation of heterocyclic amines, benzopyrenes, and polycyclic aromatic ...
*  Oxoborane
Comparison of Anionic and Lewis Acid Stabilized N-Heterocyclic Oxoboranes: Their Facile Synthesis from a Borinic Acid. ... A Lewis acid-stabilized adduct of an oxoborane is (NacNacB=O.AlCl3. In this compound the oxygen atom is coordinated to ... The BO bond length is 130 pm (compare to 136 pm in regular boronic acids). Related systems are known. In trans-[(Cy3P)2PtBr(BO ... doi:10.1002/anie.201003379 Synthesis and Characterization of a Coordinated Oxoborane: Lewis Acid Stabilization of a Boron− ...
*  Nutritional genomics
During cooking of muscle meat at high temperature, some amino acids may react with creatine to give heterocyclic aromatic ... NAT is involved in acetylation of heterocyclic aromatic amines found in heated products especially well cooked red meat. ... fatty acids, triglycerides and phospholipids). In mice models, overexpression of SREBP-1c led to fatty livers, ... increase in High density lipoprotein-cholesterol levels with the increase in the dietary intake of polyunsaturated fatty acids ...
*  Grepafloxacin
"Synthesis of 5-methyl-4-oxo-quinolinecarboxylic acids". Journal of Heterocyclic Chemistry. 27 (6): 1609. doi:10.1002/jhet. ... aqueous acid then hydrolyzes the oxazoline to afford the free acid (6). This last intermediate is then taken on to the ... The scheme starts with the conversion of the carboxylic acid in (1) to its dimethyloxazoline derivative (3) by reaction with ... 8-trisubstituted-6-fluoroquinoline-3-carboxylic acids". Journal of Medicinal Chemistry. 34 (3): 1155. doi:10.1021/jm00107a040. ...
*  Acetonedicarboxylic acid
... methylidene Derivatives in the Synthesis of Heterocyclic Systems". Advances in Heterocyclic Chemistry. Advances in Heterocyclic ... Acetonedicarboxylic acid, 3-oxoglutaric acid or β-ketoglutaric acid is a simple dicarboxylic acid. It is commercially available ... Acetonedicarboxylic acid is well-known to be used in the Robinson tropinone synthesis. Acetonedicarboxylic acid also finds use ... alpha-Ketoglutaric acid 1,3-Acetonedicarboxylic acid[permanent dead link] at Sigma-Aldrich (safety data sheet) Roger Adams; H. ...
*  PDE3 inhibitor
An adjacent acid proton. A small sized alkyl substituent on the heterocyclic ring. A relatively flat overall topography. An ... The heterocycle region: Within each heterocycle there is the presence of a dipole and an adjacent acid proton (an amide ... Alkyl groups, limited to either methyl or ethyl, on the heterocyclic ring usually enhance potency, with occasional exceptions. ... A large number of heterocyclic compounds have been synthesized during related research. These compounds constitute a second ...
*  Carborane acid
This was shown in a single crystal X-ray diffraction study revealing shortened bond lengths in the heterocyclic portion of the ... classical superacids are often mixtures of a Brønsted acid and Lewis acid (e.g. HF/SbF5). Despite being the strongest acid, the ... such as fluorosulfuric acid or hydrofluoric acid, readily donate protons in a similar way to carborane acid, but leave behind ... The known acid H(CHB11F11) with one fewer fluorine is expected to have a pKa close to this value. Carborane acids differ from ...
*  LSm
... between planar side chains of two amino acids, hydrogen bonding to the heterocyclic base and/or the ribose, and salt bridges to ... 32 nucleic acids long (14 amino acids), that were very similar in each LSm homolog, and were separated by a non-conserved ... The order of these seven LSm proteins in this ring is not known, but based on amino acid sequence homology with the Sm proteins ... The smith antigen was found to be a complex of ribonucleic acid (RNA) molecules and multiple proteins. A set of uridine-rich ...
*  Heterocyclic amine
Pyridoxine or vitamin B6, it becomes a major compound in the metabolism of amino acids. Pyrimidine is a heterocyclic amine that ... Heterocyclic amines, also sometime referred to as HCAs, are chemical compounds containing at least one heterocyclic ring, which ... Research has shown that heterocyclic amine formation in meat occurs at high cooking temperatures. For example, heterocyclic ... The biological functions of heterocyclic amines vary, including vitamins and carcinogens. Carcinogenic heterocyclic amines are ...
*  Glycol nucleic acid
Journal of Heterocyclic Chemistry (1971), 8(5), 827-9. Acevedo, Oscar L.; Andrews, Robert S. Synthesis of propane-2,3-diol ... Oligonucleotide synthesis Abiogenesis Threose nucleic acid Peptide nucleic acid Locked nucleic acid Zhang Lilu; Peritz Adam; ... Glycol nucleic acid (GNA) is a polymer similar to DNA or RNA but differing in the composition of its "backbone". GNA is not ... It is possibly the simplest of the nucleic acids, so making it a hypothetical precursor to RNA. ...
*  Metabolism
... lack all amino acid synthesis and take their amino acids directly from their hosts. All amino acids are synthesized from ... These bases are heterocyclic rings containing nitrogen, classified as purines or pyrimidines. Nucleotides also act as coenzymes ... Fatty acids are made by fatty acid synthases that polymerize and then reduce acetyl-CoA units. The acyl chains in the fatty ... Amino acid synthesis depends on the formation of the appropriate alpha-keto acid, which is then transaminated to form an amino ...
Synthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic Acid  Synthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic Acid
A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to ... HeLa cells showed the highest sensitivity to the compounds and heterocyclic esters with no substituent on catechol ring showed ... Both heterocycle esters of caffeic acid and their arylsulfonyl derivatives were evaluated for their cytotoxic activity against ... Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, ...
more infohttp://ijpr.sbmu.ac.ir/article_1355.html
Amino esters of heterocyclic dicarboxylic acids | SpringerLink  Amino esters of heterocyclic dicarboxylic acids | SpringerLink
8-tetracyanoquinodimethane were obtained by the condensation of the acid dichlorides of furan-2,5-dicarboxylic acid and... ... 5-dicarboxylic acid and tetrahydrothiophene-2,5-dicarboxylic acid with 8-hydroxy- and 5,7-dibromo-8-hydroxyquinolines. Almost ... Ester Organic Chemistry Antimicrobial Activity Dicarboxylic Acid Dichloride Translated from Khimiya Geterotsiklicheskikh ... 8-tetracyanoquinodimethane were obtained by the condensation of the acid dichlorides of furan-2, ...
more infohttps://link.springer.com/article/10.1007/BF00477431
Naphthenic and heterocyclic retinoic acid analogues - Patent # 4456618 - PatentGenius  Naphthenic and heterocyclic retinoic acid analogues - Patent # 4456618 - PatentGenius
2-naphthoic acid, (E)-1-(5-carbethoxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, (E)-1-(5- ... Naphthenic and heterocyclic retinoic acid analogues such as (E)-6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2- ... Naphthenic and heterocyclic retinoic acid analogues such as (E)-6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2- ... A principal object of this invention is to provide new naphthenic and heterocyclic retinoic acid analogues that are ...
more infohttp://www.patentgenius.com/patent/4456618.html
WO1985002847A1 - Carbocyclic and heterocyclic carbon acid esters and amides of nitrogenous or non nitrogenous bridged or...  WO1985002847A1 - Carbocyclic and heterocyclic carbon acid esters and amides of nitrogenous or non nitrogenous bridged or...
hydrochloric acid, malonic acid, hydrobromic acid, maleic acid, malic acid, fumaric acid, methanesulfonic acid, oxalic acid and ... Aromatic esters or amides of carboxylic acid and sulfonic acid EP0765924B1 (en) * 1992-07-10. 2002-05-22. E.I. Du Pont De ... Carbocyclic and heterocyclic carbon acid esters and amides of nitrogenous or non nitrogenous bridged or unbridged amines or ... Carbocyclic and heterocyclic carbon acid esters and amides of nitrogenous or non nitrogenous bridged or unbridged amines or ...
more infohttps://patents.google.com/patent/WO1985002847A1/en
N-Heterocyclic Carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis  N-Heterocyclic Carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis
... News Aug 25, 2012 ... This Commentary will briefly highlight the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis as a new and ... The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative catalysis, ... The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of ...
more infohttps://www.technologynetworks.com/tn/news/nheterocyclic-carbenebr%C3%B8nsted-acid-cooperative-catalysis-as-a-powerful-tool-in-organic-synthesis-203202
US Patent # 8,143,423. N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids - Patents.com  US Patent # 8,143,423. N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids - Patents.com
The process comprises reacting an aldehyde with a nitroso compound in the presence of a N-heterocyclic carbene (NHC) catalyst. ... A process for preparing hydroxamic acids is provided. ... C. Hydroxamic Acid In an embodiment of the present invention, ... N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids Abstract. A process for preparing hydroxamic acids is ... Yields above 75% of the corresponding hydroxamic acids for a variety of aryl, alkyl, alkenyl, and heterocyclic aldehydes were ...
more infohttp://patents.com/us-8143423.html
Heterocyclic Chemistry: SYNTHESIS OF 3-HydroxyCinchoninic acid  Heterocyclic Chemistry: SYNTHESIS OF 3-HydroxyCinchoninic acid
After the workup the 3-hydroxycinchoninic acid is isolated as a yellow solid(60-71%).. For more information:. Organic Syntheses ... The synthesis of the 3-hydroxycinchoninic acid has been performed with the reaction a commercially available isatin in presence ... of chloropyruvic acid (previously synthesized from pyruvic acid and sulfuryl chloride in 95-98% Yield.) in a aqueous potassium ...
more infohttp://hetchem.blogspot.com/2007/02/synthesis-of-3-hydroxycinchoninic-acid.html
Beryllium and growth. II. The effect of beryllium on plant growth (Journal Article) | ETDEWEB  Beryllium and growth. II. The effect of beryllium on plant growth (Journal Article) | ETDEWEB
CARBOXYLIC ACIDS; DATA; ELEMENTS; ENZYMES; ESTERASES; FOOD; FRUITS; GROWTH; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; ... 3) The pH of the nutrient solution is critical: at acid pH's, beryllium is highly toxic, and growth increase due to beryllium ... 3) The pH of the nutrient solution is critical: at acid pH's, beryllium is highly toxic, and growth increase due to beryllium ... HYDROLASES; INFORMATION; METALS; NUMERICAL DATA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHYTOCHROMES; ...
more infohttps://www.osti.gov/etdeweb/biblio/5353447
RCSB PDB - ORO Ligand Summary Page  RCSB PDB - ORO Ligand Summary Page
... nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to ... Orotic Acid. Groups. experimental. Categories. *Acids, Heterocyclic. *Heterocyclic Compounds. *Heterocyclic Compounds, 1-Ring ... OROTIC ACID. ORO as a free ligand exists in 95 entries. Examples include: 5TBO 1UUM 2FQI ... Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. , PMID:21059682 ...
more infohttps://www.rcsb.org/ligand/ORO
Patent search - Patent Attorneys - Patent Applications - Patent Sale  Patent search - Patent Attorneys - Patent Applications - Patent Sale
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG CO-A reductase inhibitors , 1,1- and ... Lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines. Compounds of the formulae ##STR1## ... Retinoic acid mimetic anilides. The present invention is concerned with compounds of formula ##STR1## the N-oxides, the ... Aralkyl and aralkylidene heterocyclic lactams and imides. The present invention relates to compounds of the formula Orosco ## ...
more infohttp://patents.com/search?keyword=medicine&page=98
Epigenetics and Breast Cancers  Epigenetics and Breast Cancers
4. Food Ingredients and Epigenetic Mechanisms in Breast Cancers: Folate/Methionine, Betacarotene/Arachidonic Acid, Heterocyclic ... as well as arachidonic acid (AA), an omega-6 fatty acid present in vegetable oils, may promote angiogenesis by increasing ... B. Kiec-Wilk, U. Razny, J. C. Mathers, and A. Dembinska-Kiec, "DNA methylation, induced by β-carotene and arachidonic acid, ... The omega-3 fatty acids found in animal meats like chicken and egg yolks promote cellular uptake of BC and AA. Thus, avoidance ...
more infohttps://www.hindawi.com/journals/ogi/2012/602720/
2,4-Difluorophenol | 367-27-1  2,4-Difluorophenol | 367-27-1
6-Trifluorophenol PENTAFLUOROPHENOXYACETIC ACID PENTAFLUOROPHENYL METHACRYLATE 2,3,4-TRIFLUOROPHENOL FMOC-SER(TBU)-OPFP 2,3,4,5 ...
more infohttps://www.chemicalbook.com/ChemicalProductProperty_EN_CB2318257.htm
Molecules | Free Full-Text | Subcritical Water Chromatography with Electrochemical Detection  Molecules | Free Full-Text | Subcritical Water Chromatography with Electrochemical Detection
The classes of analytes studied were neurotransmitters/metabolites, nucleic acids/heterocyclic bases, and capsaicinoids. Both ... The classes of analytes studied were neurotransmitters/metabolites, nucleic acids/heterocyclic bases, and capsaicinoids. Both ... nucleic acids; heterocyclic bases; capsaicinoids subcritical water chromatography; hot water chromatography; electrochemical ...
more infohttp://www.mdpi.com/1420-3049/22/6/962
771-61-9 - Pentafluorophenol, 99% - PFP - A15574 - Alfa Aesar  771-61-9 - Pentafluorophenol, 99% - PFP - A15574 - Alfa Aesar
It is also used for peptide coupling and heterocyclic acid derivatives. It is involved in the preparation of pentafluorophenyl ... PFP esters have been recommended for preparation of derivatives of heterocyclic acids, effective where DCC or DIC alone fail: ... For preparation and use of the moderately stable PFP formate as a formylating agent for amines and amino acids, see: Synthesis ... Chem., 1421 (1973); Tetrahedron Lett., 1785 (1974). With Fmoc-protected amino acids, the coupling takes place very rapidly, ...
more infohttps://www.alfa.com/en/catalog/A15574/
Patent US4355040 - Hypotensive imidazole-5-acetic acid derivatives - Google Patents  Patent US4355040 - Hypotensive imidazole-5-acetic acid derivatives - Google Patents
Novel imidazole-5-acetic acid derivatives of the formula: ##STR1## wherein R1 is lower alkyl, cycloalkyl or, phenyl which may ... Heterocyclic carboxylic acids and esters. EP0614890A3 *. 9 Mar 1994. 11 Jan 1995. Lonza Ag. Optionally 2-substituted 5- ... sulfuric acid, etc.) and with organic acids (e.g. acetic acid, propionic acid, maleic acid, succinic acid, malic acid, etc.), ... Among preferred examples of the acid are mineral acids such as sulfuric acid and hydrochloric acid. The concentration of such ...
more infohttp://www.google.com.au/patents/US4355040
Class 436: 
CHEMISTRY:  ANALYTICAL AND  IMMUNOLOGICAL TESTING


 / U.S. Patent Classification Definitions  Class 436: CHEMISTRY: ANALYTICAL AND IMMUNOLOGICAL TESTING / U.S. Patent Classification Definitions
Included herein are analysis involving heterocyclic acid anhydrides, lactones or lactams. SEE OR SEARCH CLASS: 540, through 549 ... Acetic acid and salicyclic acid are classifiable herein. SEE OR SEARCH THIS CLASS, SUBCLASS: 89 and 90, for chemical tests for ... for synthesis of amino acids and 91.3 for synthesis of ribonucleic acids, subclass 6 for tests for nucleic acid. 514, Drug, Bio ... INORGANIC ACID OR BASE (E.G., HC1, SULFURIC ACID, ETC.): This subclass is indented under the class definition. Subject matter ...
more infohttps://www.uspto.gov/web/offices/ac/ido/oeip/taf/def/436.htm
  • The direct intramolecular stereospecific substitution of the hydroxyl group in stereogenic secondary alcohols was successfully accomplished by phosphinic acid catalysis. (diva-portal.org)
  • The second part (Chapters 3 and 4) describes the direct intramolecular stereospecific nucleophilic substitution of the hydroxyl group in enantioenriched alcohols by Lewis acid and Brønsted acid/base catalysis. (diva-portal.org)
  • In non-photosynthetic eukaryotes such as animals, insects, fungi, and protozoa, as well as the α-proteobacteria group of bacteria, the committed step for porphyrin biosynthesis is the formation of δ-aminolevulinic acid (δ-ALA, 5-ALA or dALA) by the reaction of the amino acid glycine with succinyl-CoA from the citric acid cycle. (wikipedia.org)
  • Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. (ac.ir)
  • 3) The pH of the nutrient solution is critical: at acid pH's, beryllium is highly toxic, and growth increase due to beryllium only appears at initial pH's above 11.2, although this initial pH rapidly falls to neutrality during the experimental period. (osti.gov)
  • In plants, algae, bacteria (except for the α-proteobacteria group) and archaea, it is produced from glutamic acid via glutamyl-tRNA and glutamate-1-semialdehyde. (wikipedia.org)