Acids, Carbocyclic: Carboxylic acids that have a homocyclic ring structure in which all the ring atoms are carbon.Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.Inorganic Chemicals: A broad class of substances encompassing all those that do not include carbon and its derivatives as their principal elements. However, carbides, carbonates, cyanides, cyanates, and carbon disulfide are included in this class.Pyrimidine Nucleosides: Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES.Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor: Enzymes that catalyze the joining of glutamine-derived ammonia and another molecule. The linkage is in the form of a carbon-nitrogen bond. EC 6.3.5.Adenosylhomocysteinase: An enzyme which catalyzes the catabolism of S-ADENOSYLHOMOCYSTEINE to ADENOSINE and HOMOCYSTEINE. It may play a role in regulating the concentration of intracellular adenosylhomocysteine.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Distamycins: Oligopeptide antibiotics from Streptomyces distallicus. Their binding to DNA inhibits synthesis of nucleic acids.Inosine Diphosphate: An inosine nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.Malvaceae: The mallow family of the order Malvales, subclass Dilleniidae, class Magnoliopsida. Members include GOSSYPIUM, okra (ABELMOSCHUS), HIBISCUS, and CACAO. The common names of hollyhock and mallow are used for several genera of Malvaceae.Thromboxanes: Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.Ribosemonophosphates: Ribose substituted in the 1-, 3-, or 5-position by a phosphoric acid moiety.Adenosine Deaminase Inhibitors: Drugs that inhibit ADENOSINE DEAMINASE activity.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.Cytidine: A pyrimidine nucleoside that is composed of the base CYTOSINE linked to the five-carbon sugar D-RIBOSE.Thromboxane A2: An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Dideoxynucleosides: Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Polyphloretin Phosphate: A polymeric mixture of polyesters of phosphoric acid and phloretin. It blocks some cellular responses to prostaglandins.Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Inosine: A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Carbon-Nitrogen Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.GuanineAdenosine Kinase: An enzyme that catalyzes the formation of ADP plus AMP from adenosine plus ATP. It can serve as a salvage mechanism for returning adenosine to nucleic acids. EC 2.7.1.20.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Deoxyguanosine: A nucleoside consisting of the base guanine and the sugar deoxyribose.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Epoprostenol: A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Oligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Viral Plaque Assay: Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Kinetics: The rate dynamics in chemical or physical systems.
(1/8) Synthesis of telomere-mimic carbocyclic 5'-nor oligodeoxynucleotides.

Telomere-mimic S-ODNs have been synthesized and examined their effects on the proliferation of human tumor cell lines by XTT assay. Furthermore, the guanosine derivatives of carbocyclic 5'-nor nucleoside were synthesized.  (+info)

(2/8) Synthesis of carbocyclic nucleosides as potential antiviral agents.

Treatment of 1-[(1'R,2'S,3'S,4'S)-4'-methanesulfonyl-2',3'-O- isopropylidenedioxycyclopentan-1'-yl]-1-H-uracil with LiN3 gave 1-[(1'R,2'S,3'R)-2',3'-O-isopropylidenedioxy-4'- cyclopenten-1'-yl]-1-H-uracil. When KOBut was added instead of LiN3, 1-[(1'R,2'S)-2',3'-O- isopropylidenedioxy-3'-cyclopenten-1'-yl]-1-H-uracil was produced. An analogous treatment of the methanesulfonyl derivative of thymine was also carried out.  (+info)

(3/8) Synthesis of carbocyclic analogues of 4'-ethynyl- and 4'-cyano-d4T.

Synthesis of carbocyclic analogues of 4'-ethynyl and cyano-d4T (4 and 5) was investigated. The ethynyl or cyano group was constructed by conversion of the ester function of key intermediate 13. The carbocyclic unit 12 was prepared from readily available beta-keto ester 6.  (+info)

(4/8) Carbocyclic analogues of lexitropsin--DNA affinity and endonuclease inhibition.

A DNA-binding affinity and the effect on restriction enzymes activity of seven carbocyclic mono- and bis-lexitropsins and two analogues of pentamidine with unsubstituted N-terminal amine group were investigated. DNA association constants (Kapp) show that DNA affinity of mono-compounds is much weaker than netropsin and distamycin. Bis-analogues of netropsin bind DNA more strongly than mono-ligands, but without sequence-selectivity. Only pentamidine derivatives reveal preference to AT-rich sequence. The studied compounds can inhibit catalytical action of endonucleases recognizing sequence of four AT base pairs following one another.  (+info)

(5/8) Lichen photobionts show tolerance against lichen acids produced by lichen mycobionts.

In order to determine the allelopathic nature of lichen acids produced by lichen mycobionts, we compared lichen photobionts with other photosynthetic organisms in terms of inhibition of photosynthetic electron transport around photosystem II (PSII) by representative lichen acids. Whereas at the thylakoid level we found no clear difference in tolerance against lichen acids between lichen photobionts and other species, at the cellular level lichen photobionts showed strong tolerance as compared with other species. These findings suggest the presence of a lichen acid-specific exclusion or detoxification mechanism in lichen photobiont cells.  (+info)

(6/8) Clinical applications of urinary organic acids. Part 2. Dysbiosis markers.

Part 1 of this series focused on urinary organic acids as markers of detoxification; part 2 focuses on dysbiosis markers. Intestinal microbial growth is accompanied by the release of products of their metabolism that may be absorbed and excreted in urine. Several organic acids are known to be specific products of bacterial metabolic action on dietary polyphenols or unassimilated amino acids or carbohydrates. Associated gastrointestinal or neurological symptoms may result from irritation of the intestinal mucosa or systemic distribution of absorbed neurotoxic products. Detection of abnormally elevated levels of these products is a useful diagnostic tool for patients with gastrointestinal or toxicological symptoms. Test profiles of urinary organic acids associated with microbial overgrowth can include benzoate, hippurate, phenylacetate, phenylpropionate, cresol, hydroxybenzoate, hydroxyphenylacetate, hydroxyphenylpropionate and 3,4-dihydroxyphenylpropionate, indican, tricarballylate, D-lactate, and D-arabinitol. Effective treatments for the associated microbial overgrowths may be directed at reducing microbial populations, introducing favorable microbes, and restoring intestinal mucosal integrity.  (+info)

(7/8) Synthesis, characterization and activity evaluation of matrinic acid derivatives as potential antiproliferative agents.

 (+info)

(8/8) Synthetic analogues of netropsin and distamycin--synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics.

A new series of pyridine-containing analogues III-XXII of distamycin A and netrop sin was investigated by the molecular mechanics technique and molecular modelling. A pyridine analogue of netropsin (VII) is described, the first compound based on molecular studies, and two carbocyclic analogues of distamycin A with an N-terminal chloro- or bromoacetyl group (VIa, VIIa) were synthesized, as well as carbocyclic analogues of netropsin (VIIIb, Xb), potential carriers of alkylating elements. The potential use of VIa, VII, VIIa, VIIIb and Xb as carriers to place into the minor groove of DNA chemical groups capable of modifying DNA, is discussed.  (+info)

*  Intramolecular Heck reaction
The reaction may be used to produce carbocyclic or heterocyclic organic compounds with a variety of ring sizes. Chiral ... scopadulcic acid. A 6-exo cyclization sets the quaternary center and provides a neopentyl σ-palladium intermediate, which ...
*  Miroprofen
Chemically it is a carbocyclic acid and a phenylpropionate. Mikashima, H.; Goto, K. (Jan 1982). "[Inhibitory effect of 2-(4-(2- ... imidazo(1,2-a)pyridyl)phenyl) propionic acid (miroprofen) on platelet aggregation and prostaglandin I2 generation (author's ...
*  Methylene cyclopropyl acetic acid
Dihydrosterculic acid is the major carbocyclic fatty acid in the seed oils of Litchi chinensis. It is a cyclopropene fatty acid ... Biochem J 1962;82:385-9. PMC 1243468 "Natural alicyclic fatty acids, section:Cyclopropane and Cyclopropene Fatty Acids from ... Methylene cyclopropyl acetic acid (MCPA) is a compound found in lychee seeds. It is also a metabolite in mammalian digestion ... Methylene cyclopropyl acetic acid (MCPA) is found in lychee seeds and also a toxic metabolite in mammalian digestion after ...
*  Raymond C. Stevens
... and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity J Am Chem Soc 119: 681-90; M. ... The human Lysophosphatidic acid receptor 1 (LPAR1), the human angiotensin II receptor type 1 (AT1R), human P2Y receptor 1 (P2Y1 ... Crystal structure of human lysophosphatidic acid receptor 1 Cell 161: 1633-1643 H. Zhang, H. Unal, C. Gati, G.W. Han, W. Liu, N ... Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors Bioorg Med Chem Lett 7: 1837-1842; C. U. Kim ...
*  Cyclopropane fatty acid
Carbocyclic fatty acids in plants: Biochemical and molecular genetic characterization of cyclopropane fatty acid synthesis of ... Cyclopropene fatty acids are even rarer than CPAs. The best-known examples are malvalic acid and sterculic acid. Sterculic acid ... Cyclopropane fatty acids (CPA) are a subgroup of fatty acids that contain a cyclopropane group. Although they are usually rare ... which catalyzes the biodesaturation of stearic acid to oleic acid. "Archived copy". Archived from the original on 2014-12-17. ...
*  Glycomimetic
Tamiflu is a carbocyclic mimic of the cell-surface carbohydrate sialic acid. Tamiflu is an enzyme inhibitor that blocks the ... either by Coulombic interaction with carboxylate amino acid side-chains in the enzyme active site, or by mimicking positive- ...
*  Carbocyclic nucleoside
Medicinal Chemistry of Nucleic Acids. Hoboken: John Wiley & Sons. pp. 1-100. ISBN 9780470596685. Rodrguez JB, Comin MJ (March ... The fluorocarbocyclic nucleoside carbocyclic 2′-ara-fluoro-guanosine was reported in 1988 as the first example of a carbocyclic ... Antiviral Carbocyclic Purine nucleosides (-)Carbovir Abacavir Entecavir Carbocyclic 2′-ara-fluoro-guanosine Entecavir, a ... There are two approaches used in the synthesis of carbocyclic nucleosides. Linear approaches to chiral carbocyclic nucleosides ...
*  Vince lactam
Vince, R.; Hua, M. "Synthesis of carbovir and abacavir from a carbocyclic precursor" Current Protocols in nucleic acid ... including carbocyclic puromycin (I), carbocyclic Ara-A (II), carbovir (III) and guanine as well as azaguanine carbocyclic ... Vince lactam has been extensively used for the preparation of various carbocyclic nucleosides with medicinal applications in ... It is named after Robert Vince who has used the structural features of this molecule for the preparation of carbocyclic ...
*  Aminoshikimic acid
It is characterized by multiple stereogenic centers and functional groups arrayed around a six-membered carbocyclic ring. ... As with shikimic acid, aminoshikimic acid is an attractive candidate for use as the core scaffold for synthesis of ... Aminoshikimic acid is also an alternative to shikimic acid as a starting material for the synthesis of neuraminidase inhibitors ... Aminoshikimic acid is an intriguing alternative to shikimic acid as a starting material for the synthesis of neuraminidase ...
*  Marjorie Constance Caserio
She spent nine years at Caltech, working on 3 and 4 membered carbocyclic ring compounds, the reactions of alcohols with ... diazomethane, the hydrolysis of diaryliodonium salts, the deanimation of nitrous acid, and benzyne reaction intermediates in ...
*  Silver trifluoromethanesulfonate
Part I. Trifluoromethanesulphonic acid" (in German), J. Chem. Soc.: pp. 4228-4232, doi:10.1039/JR9540004228 T. Gramstadt, R.N. ... salts form carbocyclic rings" (in German), J. Org. Chem. 41 (17): pp. 2882-2885, doi:10.1021/ja00879a019 Stang, Peter J.; ... Perfluoroalkanesulphonic acids" (in German), J. Chem. Soc.: pp. 173-180, doi:10.1039/JR9560000173 G.M. Whitesides, F.D. ... An early preparation method starts from the barium salt of trifluoromethanesulfonic acid (TfOH), from which the free TfOH is ...
*  Indole
Strong acids such as hydrochloric acid can, however, protonate indole. Indole is primarily protonated at the C3, rather than N1 ... Since the pyrrollic ring is the most reactive portion of indole, electrophilic substitution of the carbocyclic (benzene) ring ... The amino acid tryptophan is an indole derivative and the precursor of the neurotransmitter serotonin. Indole is a solid at ... 3-Indolepropionic acid has been shown to prevent oxidative stress and death of primary neurons and neuroblastoma cells exposed ...
*  Intramolecular reactions of diazocarbonyl compounds
5) In the presence of a catalytic amount of acid, diazomethyl ketone substrates containing a pendant double bond or aryl group ... 7) Transannular insertions, which form fused carbocyclic products, have also been observed. Yields are often low for these ... 11) A solution of the olefinic acid (0.499 g, 2.25 mmol) dissolved in benzene (20 ml, freshly distilled from calcium hydride) ... Very often, the diazocarbonyl compound is prepared and immediately used via treatment of the corresponding acid chloride with ...
*  Aromaticity
The four aromatic amino acids histidine, phenylalanine, tryptophan, and tyrosine each serve as one of the 20 basic building- ... Aromaticity also occurs in compounds that are not carbocyclic or heterocyclic; inorganic six-membered-ring compounds analogous ... Examples include trinitrotoluene (TNT), acetylsalicylic acid (aspirin), paracetamol, and the nucleotides of DNA. Aromatic ... "On Insolinic Acid". Proceedings of the Royal Society. 8: 1-3. doi:10.1098/rspl.1856.0002. "Bonding in benzene - the Kekulé ...
*  Artemisinin
Dihydroartemisinic acid then undergoes photo-oxidation to produce dihydroartemisinic acid hydroperoxide. Ring expansion by the ... and desilylation steps performed on this mono-carbocyclic intermediate, including a final singlet oxygen-utilizing ... The synthesized artemisinic acid can then be transported out, purified and chemically converted into artemisinin that they ... A three-step oxidation of amorpha-4,11-diene gives the resulting artemisinic acid. The Berkeley method was augmented using ...
*  Ferrier carbocyclization
A carbocyclic ring closure of a hex-5-enopyranoside derivative". J. Chem. Soc., Perkin Trans. 1: 1455-1458. doi:10.1039/ ... worked in the same reaction as a milder version of the Lewis acid, i-Bu3Al, which goes through a similar transition state ... Das, SK; Mallet, J-M; Sinaÿ, P (1997). "Novel Carbocyclic Ring Closure of Hex-5-enopyranosides". Angew. Chem. Int. Ed. 36 (5): ... Barton, DHR; Camara, J; Dalko, P; Géro, SD; Quiclet-Sire, B; Stütz, P (1989). "Synthesis of biologically active carbocyclic ...
*  Benzotriazole
A synthesis of the BTA involves the reaction of o-phenylenediamine, sodium nitrite and acetic acid. The conversion proceeds via ... methodology is not only limited to heterocyclization but was also successful for polynuclear hydrocarbons of small carbocyclic ... Biphenylene and benzyne can be conveniently prepared from benzotriazole by N-amination with hydroxylamine-O-sulfonic acid. The ... the BTA can lose a proton to act as a weak acid (pKa = 8.2) or accept a proton using the lone pair electrons located on its ...
*  Discovery and development of cyclooxygenase 2 inhibitors
The substituted phenyl group at the top of the channel interacts with the side-chains of amino acid residues through ... that is fused in this stilbene system has been extensively manipulated to include every imaginable heterocyclic and carbocyclic ... Celecoxib is metabolized primarily by CYP2C9 isoenzyme to carboxylic acid and also by non-CYP-dependent glucuronidation to ... These compounds differ greatly from NSAIDs that are arylalkonic acid analogs. Encouraged by the "concept testing" experiments ...
*  Cofactor F430
... with a γ-lactam ring E and a keto-containing carbocyclic ring F. It is the only natural tetrapyrrole containing nickel. Nickel ... carries out a 6-electron and 7-proton reduction of the ring system to generate the 15,173-seco-F430-173-acid (seco-F430) ...
*  Ladderane
The route to a [5]-ladderane-containing fatty acid involves dimerization of this intermediate to form an all-anti [5]-ladderane ... A New Record for Fused Carbocyclic Arrays". Journal of Organic Chemistry. 59 (21): 6131-6132. doi:10.1021/jo00100a002. Greiving ... A naturally occurring [5]-ladderane lipid, named pentacycloanammoxic acid, has been synthesized by Corey and coworkers. The ... Mascitti, Vincent; E. J. Corey (11 November 1994). "Total Synthesis of (±)-Pentacycloanammoxic Acid". Journal of the American ...
*  Organolithium reagent
Synthesis of Carbocyclic and Heterocyclic Systems". Curr. Org. Chem. 7: 275-300. doi:10.2174/1385272033372987. Quin, C.; et al ... Lithium enolate formation can be generalized as an acid-base reaction, in which the relatively acidic proton α to the carbonyl ... Organolithium reagents can also react with carbon dioxide to form carboxylic acids. In the case of enone substrates, where two ... Organolithium reagents are also superior to Grignard reagents in their ability to react with carboxylic acids to form ketones. ...
*  Heterocyclic compound
Examples of heterocyclic compounds include all of the nucleic acids, the majority of drugs, most biomass (cellulose and related ... either carbocyclic or heterocyclic, have a variety of common and systematic names. For example, with the benzo-fused ... Some noteworthy developments: 1818: Brugnatelli isolates alloxan from uric acid 1832: Dobereiner produces furfural (a furan) by ... treating starch with sulfuric acid 1834: Runge obtains pyrrole ("fiery oil") by dry distillation of bones 1906: Friedlander ...
*  Danheiser annulation
... in the presence of a Lewis Acid to give a trialkylsilylcyclopentene in a regiocontrolled annulation. R. L. Danheiser; D. J. ... New Annulation Approaches to Five and Six-Membered Carbocyclic Compounds". Tetrahedron Letters. 26 (21): 2513. doi:10.1016/ ...
*  Robert Vince (scientist)
Vince continued his work on antiviral drug candidates at the University of Minnesota, where he went on to develop carbocyclic ... Nucleotides and Nucleic Acids, in 2010. The same year, Minnesota Inventor's Congress inducted him into Minnesota Inventors Hall ... Nucleotides and Nucleic Acids April 2010: Received Honorary Doctorate of Science Degree from SUNY Buffalo September 2009: ... Nucleotides and Nucleic Acids ACS Medicinal Chemistry Hall of Fame. ...
*  Manganese-mediated coupling reactions
5) Lactonization of alkenes in the presence of acetic acid and acetate salts is a synthetically useful method for the synthesis ... oxidation may generate complex carbocyclic frameworks. Because of the limited functional group compatibility of Mn(OAc)3, ... Glacial acetic acid is the most common solvent used, and although it results in heterogeneous reaction mixtures at room ...
*  Kevlar
"Wholly aromatic carbocyclic polycarbonamide fiber having orientation... - US 3819587 A - IP.com". ip.com. Tatsuya Hongū, Glyn O ... production is expensive because of the difficulties arising from using concentrated sulfuric acid, needed to keep the water- ... and terephthaloyl chloride in a condensation reaction yielding hydrochloric acid as a byproduct. The result has liquid- ...
*  Kedarcidin
This α-amino acid is thus believed to be converted to the corresponding β-amino acid by KedY4, an aminomutase encoded in the ... Kedarcidin chromophore, beyond the carbocyclic core it shares with other enediynes, presents additional biosynthetic puzzles: ... Instead, an (R)-β-amino acid derivative was proposed and validated by the Hirama group. This revision led Hirama et al. to ... The naphthoic acid substructure has been implicated in DNA binding, likely through intercalation. To this end, kedarcidin ...
WO1985002847A1 - Carbocyclic and heterocyclic carbon acid esters and amides of nitrogenous or non nitrogenous bridged or...  WO1985002847A1 - Carbocyclic and heterocyclic carbon acid esters and amides of nitrogenous or non nitrogenous bridged or...
hydrochloric acid, malonic acid, hydrobromic acid, maleic acid, malic acid, fumaric acid, methanesulfonic acid, oxalic acid and ... Aromatic esters or amides of carboxylic acid and sulfonic acid EP0765924B1 (en) * 1992-07-10. 2002-05-22. E.I. Du Pont De ... Carbocyclic and heterocyclic carbon acid esters and amides of nitrogenous or non nitrogenous bridged or unbridged amines or ... Carbocyclic and heterocyclic carbon acid esters and amides of nitrogenous or non nitrogenous bridged or unbridged amines or ...
more infohttps://patents.google.com/patent/WO1985002847A1/en
Liquid chromatographic enantioseparation of limonene-based carbocyclic β-amino acids on zwitterionic Cinchona alkaloid-based...  Liquid chromatographic enantioseparation of limonene-based carbocyclic β-amino acids on zwitterionic Cinchona alkaloid-based...
Liquid chromatographic enantioseparation of limonene-based carbocyclic β-amino acids on zwitterionic Cinchona alkaloid-based ... Liquid chromatographic enantioseparation of limonene-based carbocyclic β-amino acids on zwitterionic Cinchona alkaloid-based ...
more infohttp://publicatio.bibl.u-szeged.hu/12511/
RCSB PDB - BHA Ligand Summary Page  RCSB PDB - BHA Ligand Summary Page
Acids, Carbocyclic. *Aminobenzoates. *Aminosalicylic Acid and Derivatives. *Aminosalicylic Acids. *Anti-Bacterial Agents ... Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the ... aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para- ... aminobenzoic acid to pteridine synthetase acts as the first step in folic acid synthesis. ...
more infohttps://www.rcsb.org/ligand/BHA
3-phenylpropionic acid - DrugBank  3-phenylpropionic acid - DrugBank
Acids, Carbocyclic. UNII. 5Q445IN5CU. CAS number. 501-52-0. Weight. Average: 150.1745 Monoisotopic: 150.068079564 Chemical ... 3-phenylpropanoic-acid / Benzenoid / Monocyclic benzene moiety / Monocarboxylic acid or derivatives / Carboxylic acid / ... Phenylpropanoic acids. Sub Class. Not Available. Direct Parent. Phenylpropanoic acids. Alternative Parents. Benzene and ... 3-phenylpropionic acid. Accession Number. DB02024 (EXPT01708) Type. Small Molecule. Groups. Experimental. Description. Not ...
more infohttps://www.drugbank.ca/drugs/DB02024
Diethylhexyl Phthalate
      - DEHP
     Summary Report | CureHunter  Diethylhexyl Phthalate - DEHP Summary Report | CureHunter
An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and ... Carboxylic Acids: 83*Carbocyclic Acids*Phthalic Acids*Diethylhexyl Phthalate: 404*mono-(2-ethylhexyl)phthalate: 68 ... An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and ...
more infohttp://www.curehunter.com/public/keywordSummaryD004051-Diethylhexyl-Phthalate-DEHP.do
Antiviral Drugs Flashcards by Chris Rodarte | Brainscape  Antiviral Drugs Flashcards by Chris Rodarte | Brainscape
"sialidase" = removes sialic acid from surface at level of glyccoproteins and glycolipids ...
more infohttps://www.brainscape.com/flashcards/antiviral-drugs-4205996/packs/6185600
Benzamides | Profiles RNS  Benzamides | Profiles RNS
Carboxylic Acids [D02.241]. *Acids, Carbocyclic [D02.241.223]. *Benzoates [D02.241.223.100]. *Benzamides [D02.241.223.100.100] ...
more infohttps://profiles.umassmed.edu/display/125552
Miroprofen - Wikipedia  Miroprofen - Wikipedia
Chemically it is a carbocyclic acid and a phenylpropionate. Mikashima, H.; Goto, K. (Jan 1982). "[Inhibitory effect of 2-(4-(2- ... imidazo(1,2-a)pyridyl)phenyl) propionic acid (miroprofen) on platelet aggregation and prostaglandin I2 generation (author's ...
more infohttps://en.wikipedia.org/wiki/Miroprofen
Kyselina kávová - Wikipédia  Kyselina kávová - Wikipédia
Chemical Land [online]. Caffeic Acid as Carbocyclic Carboxylic Acid. Dostupné online.. Zdroj[upraviť , upraviť zdroj]. Tento ... článok je čiastočný alebo úplný preklad článku Caffeic acid na anglickej Wikipédii. ...
more infohttps://sk.wikipedia.org/wiki/Kyselina_k%C3%A1vov%C3%A1
Carbocyclic - definition of carbocyclic by The Free Dictionary  Carbocyclic - definition of carbocyclic by The Free Dictionary
carbocyclic synonyms, carbocyclic pronunciation, carbocyclic translation, English dictionary definition of carbocyclic. adj. ... Acetic acid is a member of the carbocyclic acid family.. Quantum Dots Brighten Future of Lighting ... carbocyclic. Also found in: Thesaurus, Medical.. Related to carbocyclic: heterocyclic car·bo·cyc·lic. (kär′bō-sĭk′lĭk, -sī′klĭk ... Carbocyclic - definition of carbocyclic by The Free Dictionary https://www.thefreedictionary.com/carbocyclic ...
more infohttp://www.thefreedictionary.com/carbocyclic
Gene co-expression prediction bioinformatics tools | Transcription analysis - OMICtools  Gene co-expression prediction bioinformatics tools | Transcription analysis - OMICtools
Amino Acids 4 Steroids 3 Ethanol 3 Transition Elements 3 Metals, Heavy 3 Acids, Carbocyclic 2 Biogenic Amines 2 Metals, Light 2 ... Nucleic acids research 8 PLoS one 6 BMC genomics 5 BMC systems biology 4 PLoS computational biology 3 Plant physiology 3 Genome ... Topics (5): RNA-seq analysis, Hydrocarbons, Acyclic, Terpenes, Acids, Carbocyclic, Hydrocarbons, Cyclic ... Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis ...
more infohttps://omictools.com/gene-co-expression-prediction-category
DeCS Ingl s+escopo  DeCS Ingl s+escopo
D02.241 Carboxylic Acids .. D02.241.223 Acids, Carbocyclic .. D02.241.223.100 Benzoates .. D02.241.223.100.100 Benzamides .. ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Brake%20Fern
DeCS Ingl s+escopo  DeCS Ingl s+escopo
D02.241.081 Acids, Acyclic .. D02.241.081.018 Acetates .. D02.241.081.018.639 Pentetic Acid .. D02.241.223 Acids, Carbocyclic . ... m-Aminosalicylic Acid .. meta-Aminosalicylic Acid .. 5 Aminosalicylate .. 5 Aminosalicylic Acid .. Hydrochloride, Mesalamine . ... m Aminosalicylic Acid .. meta Aminosalicylic Acid .. Mesalazine .. 5-Aminosalicylate .. An anti-inflammatory agent, ... Pentetic Acid .. Ca-DTPA .. CaDTPA .. CaNa-DTPA .. Calcium Trisodium Pentetate .. DETAPAC .. Indium-DTPA .. Mn-Dtpa .. Pentacin ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Pentalog
Substitution of proline with pipecolic acid at the scissile bond converts a peptide substrate of HIV proteinase into a...  Substitution of proline with pipecolic acid at the scissile bond converts a peptide substrate of HIV proteinase into a...
Replacing the Pro by L-pipecolic acid (2-piperidinecarboxylic acid) converted the substrate into an effective inhibitor of HIV- ... A compendium of cyclic sugar amino acids and their carbocyclic and heterocyclic nitrogen analogues. *Martijn Risseeuw, Mark ... R)-α-Aminoadipic Acid: A Versatile Precursor for the Synthesis of D-Amino Acids. *Amina Sadiq, Norbert Sewald ... Recent advances in asymmetric synthesis of pipecolic acid and derivatives. *C. Kadouri-Puchot, S. Comesse ...
more infohttps://www.semanticscholar.org/paper/Substitution-of-proline-with-pipecolic-acid-at-the-Copeland-Wondrak/7f08eb10d36de48b82a41ecb7016ef9f31adb9e9
Carbocyclic | definition of carbocyclic by Medical dictionary  Carbocyclic | definition of carbocyclic by Medical dictionary
... carbocyclic explanation free. What is carbocyclic? Meaning of carbocyclic medical term. What does carbocyclic mean? ... Looking for online definition of carbocyclic in the Medical Dictionary? ... Such values were expected for a mixture containing aldehydes, ketones, and carbocyclic acids.. Characterization of ozonation ... Research and Markets: Medicinal Chemistry of Nucleic Acids - Complete, up-to-Date Coverage of Nucleic Acid Chemistry and ...
more infohttp://medical-dictionary.thefreedictionary.com/carbocyclic
DiVA - Search result  DiVA - Search result
... such as cyclic γ-amino acids and carbocyclic nucleoside precursors. ... The use of la silacarboxylic acid as an in situ CO-releasing molecule allowed the reaction to be performed single vial. The ... We present here a methodology for the Suzuki coupling of aryl chlorides with phenylboronic acid using Pd/C as a catalyst, water ... Suzuki coupling of aryl chlorides with phenylboronic acid in water, using microwave heating with simultaneous cooling2005In: ...
more infohttp://uu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%226362%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
how long does it take to pass the dead worms - lookformedical.com  how long does it take to pass the dead worms - lookformedical.com
Acids, Aldehydic (0) * Acids, Carbocyclic (9) * Esters (0) * Humic Substances (0) * Hydroxy Acids (0) ...
more infohttps://lookformedical.com/answers/en/3708/how-long-does-it-take-to-pass-the-dead-worms
Methylene cyclopropyl acetic acid - Wikipedia  Methylene cyclopropyl acetic acid - Wikipedia
Dihydrosterculic acid is the major carbocyclic fatty acid in the seed oils of Litchi chinensis. It is a cyclopropene fatty acid ... Biochem J 1962;82:385-9. PMC 1243468 "Natural alicyclic fatty acids, section:Cyclopropane and Cyclopropene Fatty Acids from ... Methylene cyclopropyl acetic acid (MCPA) is a compound found in lychee seeds. It is also a metabolite in mammalian digestion ... Methylene cyclopropyl acetic acid (MCPA) is found in lychee seeds and also a toxic metabolite in mammalian digestion after ...
more infohttps://en.wikipedia.org/wiki/Methylene_cyclopropyl_acetic_acid
Spatial Mapping of Lipids at Cellular Resolution in Embryos of Cotton | Plant Cell  Spatial Mapping of Lipids at Cellular Resolution in Embryos of Cotton | Plant Cell
2002). Carbocyclic fatty acids in plants: biochemical and molecular genetic characterization of cyclopropane fatty acid ... oleic acid; S-18:0, stearic, A-20:0: arachidic; Sc-19:1 sterculic acid; Dsc-19:0-dihydrosterculic acid; as well as those ... species were identified that contain one linoleic acid or palmitic acid and either a sterculic or dihydrosterulic acid (Figures ... Malvalic acid is present in cottonseeds but has the same chemical formula and is not distinguishable from oleic acid by MS in ...
more infohttp://www.plantcell.org/content/24/2/622?ijkey=639cc766d310c20161703e3e96c07a4e9ec46128&keytype2=tf_ipsecsha
  • Bn = benzyl, i-Bu = isobutyl) Sinaÿ proposed this reaction went through the following transition state: Sinaÿ also discovered that titanium (IV) derivatives such as [TiCl3(OiPr)] worked in the same reaction as a milder version of the Lewis acid, i-Bu3Al, which goes through a similar transition state involving the retention of configuration at the anomeric center. (wikipedia.org)
  • Some noteworthy developments: 1818: Brugnatelli isolates alloxan from uric acid 1832: Dobereiner produces furfural (a furan) by treating starch with sulfuric acid 1834: Runge obtains pyrrole ("fiery oil") by dry distillation of bones 1906: Friedlander synthesizes indigo dye, allowing synthetic chemistry to displace a large agricultural industry 1936: Treibs isolates chlorophyl derivatives from crude oil, explaining the biological origin of petroleum. (wikipedia.org)
  • Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. (rcsb.org)
  • The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. (rcsb.org)
  • The methodology is not only limited to heterocyclization but was also successful for polynuclear hydrocarbons of small carbocyclic systems. (wikipedia.org)
  • 11) A solution of the olefinic acid (0.499 g, 2.25 mmol) dissolved in benzene (20 ml, freshly distilled from calcium hydride) was stirred at 0 °C (ice bath) under nitrogen while oxalyl chloride (1.35 ml, 2.0 g, 15.75 mmol) was added dropwise. (wikipedia.org)
  • It is characterized by multiple stereogenic centers and functional groups arrayed around a six-membered carbocyclic ring. (wikipedia.org)
  • 5) In the presence of a catalytic amount of acid, diazomethyl ketone substrates containing a pendant double bond or aryl group undergo cyclization. (wikipedia.org)
  • Other lipids were imaged, including phosphatidylethanolamines, phosphatidic acids, sterols, and gossypol, indicating the broad range of metabolites and applications for this chemical visualization approach. (plantcell.org)
  • Their main role is to catalyze the transformation of arachidonic acid into the intermediate prostaglandin H2, which is the procursor of a variety of prostanoids with diverse and potent biological actions. (wikipedia.org)
  • These acids are highly reactive but the cyclopropene ring is destroyed during refining and hydrogenation of the oils. (wikipedia.org)
  • When nitrogen is introduced, the glycomimetic may become positively charged at physiological pH, meaning that it may act as an enzyme inhibitor, either by Coulombic interaction with carboxylate amino acid side-chains in the enzyme active site, or by mimicking positive-charge build-up at the transition state of the reaction, or both. (wikipedia.org)
  • com/research/1a7f3a/name_reactions_for) has announced the addition of John Wiley and Sons Ltd's new book "Name Reactions for Carbocyclic Ring Formations" to their offering. (thefreedictionary.com)
  • Yields of these reactions are generally moderate, particularly in the intermolecular case, but tandem intramolecular radical cyclizations initiated by Mn(III) oxidation may generate complex carbocyclic frameworks. (wikipedia.org)
  • 162-164 6 Claims ABSTRACT OF THE DISCLOSURE High molecular weight, chain extended copolyamidepolyamine resin compositions comprising the reaction product of a chain extension reagent with a copolyamidepolyamine intermediate which comprises the reaction product of a lactone or an alkylester of acrylic or methacrylic acid, a polyalkylene polyamine and a carboxylic acid reagent. (google.com.au)
  • The intolerance to prolonged fasting is due to inability to switch from glucose to fatty acid oxidation, impaired ketogenesis. (wikipedia.org)