AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
AcidosisAcidosis, LacticAcidosis, RespiratoryAcidosis, Renal TubularAcid-Base EquilibriumBicarbonatesHydrogen-Ion ConcentrationSodium BicarbonateAlkalosisAmmonium ChlorideMELAS SyndromeCarbon DioxideAcid-Base ImbalanceDiabetic KetoacidosisLactatesHypercapniaAlkalosis, RespiratoryLactic AcidBlood Gas AnalysisPotassium CitratePhenforminSodium-Hydrogen AntiporterAmmoniaSodium-Bicarbonate SymportersAcidsHydrochloric AcidHypokalemiaHyperkalemiaFanconi SyndromeRNA, Transfer, LeuAcid Sensing Ion ChannelsPartial PressureGlutaminaseKidneyDichloroacetic AcidNephrocalcinosisRumenEncyclopedias as TopicNephronsKidney Tubules, Distal
Acidosis
A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
Acidosis, Lactic
Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
Acidosis, Respiratory
Respiratory retention of carbon dioxide. It may be chronic or acute.
Acidosis, Renal Tubular
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Acid-Base Equilibrium
The balance between acids and bases in the BODY FLUIDS. The pH (HYDROGEN-ION CONCENTRATION) of the arterial BLOOD provides an index for the total body acid-base balance.
Bicarbonates
Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
Hydrogen-Ion Concentration
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Sodium Bicarbonate
A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Alkalosis
A pathological condition that removes acid or adds base to the body fluids.
Ammonium Chloride
An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.
MELAS Syndrome
A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
Carbon Dioxide
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Acid-Base Imbalance
Disturbances in the ACID-BASE EQUILIBRIUM of the body.
Diabetic Ketoacidosis
A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by KETOSIS; DEHYDRATION; and depressed consciousness leading to COMA.
Lactates
Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
Hypercapnia
A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
Alkalosis, Respiratory
A state due to excess loss of carbon dioxide from the body. (Dorland, 27th ed)
Lactic Acid
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Blood Gas Analysis
Measurement of oxygen and carbon dioxide in the blood.
Potassium Citrate
A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
Phenformin
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Sodium-Hydrogen Antiporter
A plasma membrane exchange glycoprotein transporter that functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.
Ammonia
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Sodium-Bicarbonate Symporters
Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.
Acids
Chemical compounds which yield hydrogen ions or protons when dissolved in water, whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water (neutralization). An extension of the term includes substances dissolved in media other than water. (Grant & Hackh's Chemical Dictionary, 5th ed)
Hydrochloric Acid
A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
Hypokalemia
Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
Hyperkalemia
Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
Fanconi Syndrome
A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY GLOMERULUS. It is usually characterized by the tubular wasting of nutrients and salts (GLUCOSE; AMINO ACIDS; PHOSPHATES; and BICARBONATES) resulting in HYPOKALEMIA; ACIDOSIS; HYPERCALCIURIA; and PROTEINURIA.
RNA, Transfer, Leu
A transfer RNA which is specific for carrying leucine to sites on the ribosomes in preparation for protein synthesis.
Acid Sensing Ion Channels
A family of proton-gated sodium channels that are primarily expressed in neuronal tissue. They are AMILORIDE-sensitive and are implicated in the signaling of a variety of neurological stimuli, most notably that of pain in response to acidic conditions.
Partial Pressure
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Glutaminase
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Dichloroacetic Acid
A derivative of ACETIC ACID that contains two CHLORINE atoms attached to its methyl group.
Nephrocalcinosis
A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.
Rumen
The first stomach of ruminants. It lies on the left side of the body, occupying the whole of the left side of the abdomen and even stretching across the median plane of the body to the right side. It is capacious, divided into an upper and a lower sac, each of which has a blind sac at its posterior extremity. The rumen is lined by mucous membrane containing no digestive glands, but mucus-secreting glands are present in large numbers. Coarse, partially chewed food is stored and churned in the rumen until the animal finds circumstances convenient for rumination. When this occurs, little balls of food are regurgitated through the esophagus into the mouth, and are subjected to a second more thorough mastication, swallowed, and passed on into other parts of the compound stomach. (From Black's Veterinary Dictionary, 17th ed)
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Nephrons
The functional units of the kidney, consisting of the glomerulus and the attached tubule.
Kidney Tubules, Distal
The portion of renal tubule that begins from the enlarged segment of the ascending limb of the LOOP OF HENLE. It reenters the KIDNEY CORTEX and forms the convoluted segments of the distal tubule.

Hypokalaemic paralysis revealing Sjogren syndrome in an elderly man. (1/246)

A 73 year old white man presented with life threatening hypokalaemic paralysis requiring admission to an intensive care unit. Biochemical investigations showed severe hypokalaemia with hyperchloraemic metabolic acidosis, a spot urine pH of 6.5, and a positive urinary anion gap, establishing the diagnosis of distal renal tubular acidosis. Autoimmune tests revealed Sjogren syndrome as the underlying cause of the distal renal tubular acidosis. Full recovery followed potassium and alkali replacement. This dramatic presentation of Sjogren syndrome has not previously been reported in an elderly man.  (+info)

The occurrence of renal involvement in primary Sjogren's syndrome: a study of 78 patients. (2/246)

OBJECTIVE: To ascertain the occurrence of renal involvement in patients with primary Sjogren's syndrome (pSS). METHODS: Urinary total protein excretion from 24 h urine collection, as well as urinary excretion rates of albumin, alpha-1 microglobulin (alpha1m) and IgG from overnight 8 h collections, were determined from 78 pSS patients (75 females, three males). Urine acidification capacity after oral ammonium chloride load was tested in 55 of these patients. RESULTS: Mild proteinuria (0.15-0.42 g/24 h) was observed in 34 patients (44%). Increased urinary excretion rates of albumin (>/=20 microgram/min), alpha1m (>/=7.0 microgram/min) or IgG (>/=5.0 microgram/min) were detected in nine (12%), nine (12%) and 11 patients (14%), respectively. Latent or overt distal renal tubular acidosis (dRTA) was observed in 18 out of 55 patients with pSS (33%). These patients had a longer duration of the disease (10+/-4 vs 8+/-4 yr; P+info)

Autosomal recessive distal renal tubular acidosis associated with Southeast Asian ovalocytosis. (3/246)

BACKGROUND: A defect in the anion exchanger 1 (AE1) of the basolateral membrane of type A intercalated cells in the renal collecting duct may result in a failure to maintain a cell-to-lumen H+ gradient, leading to distal renal tubular acidosis (dRTA). Thus, dRTA may occur in Southeast Asian ovalocytosis (SAO), a common AE1 gene abnormality observed in Southeast Asia and Melanesia. Our study investigated whether or not this renal acidification defect exists in individuals with SAO. METHODS: Short and three-day NH4Cl loading tests were performed in 20 individuals with SAO and in two subjects, including their families, with both SAO and dRTA. Mutations of AE1 gene in individuals with SAO and members of the two families were also studied. RESULTS: Renal acidification in the 20 individuals with SAO and in the parents of the two families was normal. However, the two clinically affected individuals with SAO and dRTA had compound heterozygosity of 27 bp deletion in exon 11 and missense mutation G701D resulting from a CGG-->CAG substitution in exon 17 of the AE1 gene. Red cells of the two subjects with dRTA and SAO and the family members with SAO showed an approximate 40% reduction in sulfate influx with normal 4,4'-di-isothiocyanato-stilbene-2,2'-disulfonic acid sensitivity and pH dependence. CONCLUSION: These findings suggest that compound heterozygosity of abnormal AE1 genes causes autosomal recessive dRTA in SAO.  (+info)

Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34. (4/246)

Failure of distal nephrons to excrete excess acid results in the "distal renal tubular acidoses" (dRTA). Early childhood features of autosomal recessive dRTA include severe metabolic acidosis with inappropriately alkaline urine, poor growth, rickets, and renal calcification. Progressive bilateral sensorineural hearing loss (SNHL) is evident in approximately one-third of patients. We have recently identified mutations in ATP6B1, encoding the B-subunit of the collecting-duct apical proton pump, as a cause of recessive dRTA with SNHL. We now report the results of genetic analysis of 13 kindreds with recessive dRTA and normal hearing. Analysis of linkage and molecular examination of ATP6B1 indicated that mutation in ATP6B1 rarely, if ever, accounts for this phenotype, prompting a genomewide linkage search for loci underlying this trait. The results strongly supported linkage with locus heterogeneity to a segment of 7q33-34, yielding a maximum multipoint LOD score of 8.84 with 68% of kindreds linked. The LOD-3 support interval defines a 14-cM region flanked by D7S500 and D7S688. That 4 of these 13 kindreds do not support linkage to rdRTA2 and ATP6B1 implies the existence of at least one additional dRTA locus. These findings establish that genes causing recessive dRTA with normal and impaired hearing are different, and they identify, at 7q33-34, a new locus, rdRTA2, for recessive dRTA with normal hearing.  (+info)

NH4+ secretion in inner medullary collecting duct in potassium deprivation: role of colonic H+-K+-ATPase. (5/246)

NH4+ secretion in inner medullary collecting duct in potassium deprivation: Role of colonic H+-K+-ATPase. BACKGROUND: In K+ deprivation (KD), gastric (g) H+-K+-ATPase (HKA) is suppressed, whereas colonic (c) HKA is induced in the terminal inner medullary collecting duct (IMCD). We hypothesized that in KD, cHKA is induced and can mediate the secretion of NH4+. METHODS: Rats were sacrificed after 2, 3, 6, or 14 days on regular (NML) or K+-free (KD) diet. mRNA expression of HKA isoforms in terminal inner medulla was examined and correlated with NH4+ secretion in perfused IMCD in vitro. RESULTS: Urinary NH4+ excretion increased after K+-free diet for six days. In terminal inner medulla, cHKA expression was strongly induced, whereas gHKA expression was decreased. NH4+ secretion increased by 62% in KD (JtNH4+ 0.57 vs. 0.92 pmol/min/mm tubule length, P < 0.001). Ouabain (1 mM) in perfusate inhibited NH4+ secretion in KD by 45% (P < 0.002) but not in NML. At luminal pH 7.7, which inhibits NH3 diffusion, NH4+ secretion in IMCD was 140% higher in KD (0.36 vs. 0.15, P < 0.03) and was sensitive to ouabain. ROMK-1 mRNA expression was induced in parallel with cHKA in inner medulla. CONCLUSIONS: These data suggest that in KD, cHKA replaces gHKA and mediates enhanced secretion of NH4+ (and H+) into the lumen facilitated by K+ recycling through ROMK-1.  (+info)

Study of urinary acidification in patients with idiopathic hypocitraturia. (6/246)

Hypocitraturia (HCit) is one of the most remarkable features of renal tubular acidosis, but an acidification defect is not seen in the majority of hypocitraturic patients, whose disease is denoted idiopathic hypocitraturia. In order to assess the integrity of urinary acidification mechanisms in hypocitraturic idiopathic calcium stone formers, we studied two groups of patients, hypocitraturic (HCit, N = 21, 39.5 +/- 11.5 years, 11 females and 10 males) and normocitraturic (NCit, N = 23, 40.2 +/- 11.7 years, 16 females and 7 males) subjects, during a short ammonium chloride loading test lasting 8 h. During the baseline period HCit patients showed significantly higher levels of titratable acid (TA). After the administration of ammonium chloride, mean urinary pH (3rd to 8th hour) and TA and ammonium excretion did not differ significantly between groups. Conversely, during the first hour mean urinary pH was lower and TA and ammonium excretion was higher in HCit. The enhanced TA excretion by HCit during the baseline period and during the first hour suggests that the phosphate buffer mechanism is activated. The earlier response in ammonium excretion by HCit further supports other evidence that acidification mechanisms react promptly. The present results suggest that in the course of lithiasic disease, hypocitraturia coexists with subtle changes in the excretion of hydrogen ions in basal situations.  (+info)

Hypokalaemic paralysis. (7/246)

Hypokalaemic paralysis is a relatively uncommon but potentially life-threatening clinical syndrome. If recognised and treated appropriately, patients recover without any clinical sequellae. The syndrome of hypokalaemic paralysis represents a heterogeneous group of disorders characterised clinically by hypokalaemia and acute systemic weakness. Most cases are due to familial or primary hypokalaemic periodic paralysis; sporadic cases are associated with numerous other conditions including barium poisoning, hyperthyroidism, renal disorders, certain endocrinopathies and gastrointestinal potassium losses. The age of onset, race, family history, medications, and underlying disease states can help in identifying the cause of hypokalaemic paralysis. Initial therapy of the patient with hypokalaemic paralysis includes potassium replacement and search for underlying aetiology. Further management depends on the aetiology of hypokalaemia, severity of symptoms, and duration of disease. This review presents the differential diagnosis for hypokalaemic paralysis and discusses management of the syndrome.  (+info)

Renal involvement in primary Sjogren's syndrome. (8/246)

Renal involvement was evaluated in 62 patients with primary Sjogren's syndrome, classified according to criteria proposed by The European Classification Criteria Group. Urine concentration capacity was tested using intranasal 1-desamino-8-D-arginine-vasopressin. For patients with urine pH>5.5 without metabolic acidosis (n=28), an acidification test with ammonium chloride was performed. Urinary citrate, albumin, NAG, ALP and beta2-microglobulin were measured and creatinine clearance was calculated. Maximum urine concentration capacity and creatinine clearance were reduced in 13 (21%). Albumin excretion was >30 microg/min in only one patient (1.6%). Seven patients (11.3%) had complete or incomplete distal renal tubular acidosis (dRTA), four had reduced creatinine clearance and five had reduced maximum urine concentration capacity. The ratio of citrate/creatinine in spot urine was below the 2.5 percentile in all patients with complete or incomplete dRTA. The prevalence of dRTA was lower than in previous studies. There were also few patients with signs of glomerular disease (1.6%). The use of citrate:creatinine ratio in spot urine can be a helpful method in identifying patients with complete or incomplete dRTA.  (+info)

Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis - Zurich Open...Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis - Zurich Open...
Distal renal tubular acidosis is a rare renal tubular disorder characterized by hyperchloremic metabolic acidosis and impaired urinary acidification. Mutations in three genes (ATP6V0A4, ATP6V1B1 and SLC4A1) constitute a monogenic causation in 58-70% of familial cases of distal renal tubular acidosis. Recently, mutations in FOXI1 have been identified as an additional cause. Therefore, we hypothesized that further monogenic causes of distal renal tubular acidosis remain to be discovered. Panel sequencing and/or whole exome sequencing was performed in a cohort of 17 families with 19 affected individuals with pediatric onset distal renal tubular acidosis. A causative mutation was detected in one of the three classical known distal renal tubular acidosis genes in 10 of 17 families. The seven unsolved families were then subjected to candidate whole exome sequencing analysis. Potential disease causing mutations in three genes were detected: ATP6V1C2, which encodes another kidney specific subunit of ...
https://www.zora.uzh.ch/id/eprint/182479/
Renal tubular acidosis, distal, autosomal dominant | definition of renal tubular acidosis, distal, autosomal dominant by...Renal tubular acidosis, distal, autosomal dominant | definition of renal tubular acidosis, distal, autosomal dominant by...
Looking for online definition of renal tubular acidosis, distal, autosomal dominant in the Medical Dictionary? renal tubular acidosis, distal, autosomal dominant explanation free. What is renal tubular acidosis, distal, autosomal dominant? Meaning of renal tubular acidosis, distal, autosomal dominant medical term. What does renal tubular acidosis, distal, autosomal dominant mean?
https://medical-dictionary.thefreedictionary.com/renal+tubular+acidosis%2C+distal%2C+autosomal+dominant
distal Renal tubular acidosis (dRTA) - Medical Need
SLC4A1-associated distal renal tubular acidosis is a kidney (renal) disorder that sometimes includes blood cell abnormalities. The kidneys normally filter fluid and waste products from the body and remove them in urine; however, in people with distal renal tubular acidosis, the kidneys are unable to remove enough acid from the body, and the blood becomes too acidic. This chemical imbalance is called metabolic acidosis. The inability to remove acids from the body often results in slowed growth and may also lead to softening and weakening of the bones, called rickets in children and osteomalacia in adults.. This bone disorder is characterized by bone pain, bowed legs, and difficulty walking. In addition, most children and adults with SLC4A1-associated distal renal tubular acidosis have excess calcium in the urine (hypercalciuria), calcium deposits in the kidneys (nephrocalcinosis), and kidney stones (nephrolithiasis). In rare cases, these kidney abnormalities lead to life-threatening kidney ...
http://medicalneed.com/patients/renal-tubular-acidosis/
Distal renal tubular acidosis - WikipediaDistal renal tubular acidosis - Wikipedia
Distal renal tubular acidosis (dRTA) or Type 1 renal tubular acidosis (RTA) is the classical form of RTA, being the first described. Distal RTA is characterized by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct of the distal nephron. This failure of acid secretion may be due to a number of causes, and it leads to an inability to acidify the urine to a pH of less than 5.3. Because renal excretion is the primary means of eliminating acid from the body, there is consequently a tendency towards acidemia. This leads to the clinical features of dRTA: Normal anion gap metabolic acidosis/acidemia Hypokalemia Urinary stone formation (related to alkaline urine, hypercalciuria, and low urinary citrate). Nephrocalcinosis (deposition of calcium in the substance of the kidney) Bone demineralisation (causing rickets in children and osteomalacia in adults) The symptoms and sequelae of dRTA are variable and range from being completely asymptomatic, to loin pain and ...
https://en.wikipedia.org/wiki/Distal_renal_tubular_acidosis
Hypokalemic Distal Renal Tubular Acidosis<...
TY - JOUR. T1 - Hypokalemic Distal Renal Tubular Acidosis. AU - Vallés, Patricia G.. AU - Batlle, Daniel. PY - 2018/7. Y1 - 2018/7. N2 - Distal renal tubular acidosis (DRTA) is defined as hyperchloremic, non-anion gap metabolic acidosis with impaired urinary acid excretion in the presence of a normal or moderately reduced glomerular filtration rate. Failure in urinary acid excretion results from reduced H+ secretion by intercalated cells in the distal nephron. This results in decreased excretion of NH4 + and other acids collectively referred as titratable acids while urine pH is typically above 5.5 in the face of systemic acidosis. The clinical phenotype in patients with DRTA is characterized by stunted growth with bone abnormalities in children as well as nephrocalcinosis and nephrolithiasis that develop as the consequence of hypercalciuria, hypocitraturia, and relatively alkaline urine. Hypokalemia is a striking finding that accounts for muscle weakness and requires continued treatment ...
https://www.scholars.northwestern.edu/en/publications/hypokalemic-distal-renal-tubular-acidosis
distal Renal Tubular Acidosis (dRTA) - Medical Need
Both the autosomal dominant and autosomal recessive forms of SLC4A1-associated distal renal tubular acidosis are caused by mutations in the SLC4A1 gene. This gene provides instructions for making the anion exchanger 1 (AE1) protein, which transports negatively charged atoms (anions) across cell membranes. Specifically, AE1 exchanges negatively charged atoms of chlorine (chloride ions) for negatively charged bicarbonate molecules (bicarbonate ions). The AE1 protein is found in the cell membrane of kidney cells and red blood cells. In kidney cells, the exchange of bicarbonate through AE1 allows acid to be released from the cell into the urine. In red blood cells, AE1 attaches to other proteins that make up the structural framework (the cytoskeleton) of the cells, helping to maintain their structure.. The SLC4A1 gene mutations involved in either form of SLC4A1-associated distal renal tubular acidosis lead to production of altered AE1 proteins that cannot get to the correct location in the cell ...
http://medicalneed.com/healthcare-professionals/renal-tubular-acidosis/
Proximal Renal Tubular Acidosis (Type II)Medvin2u.net
Proximal Renal Tubular Acidosis (Type II),Causes of PRTA, Clinical Features and Symptoms of PRTA, Diagnosis and treatment of PRTA,Prognosis of PRTA
http://medvin2u.net/proximal-renal-tubular-acidosis-type-ii/
Renal tubular acidosis, food allergy, IgA and IgG deficiency in Mexican children | Clinical and Translational Allergy | Full...Renal tubular acidosis, food allergy, IgA and IgG deficiency in Mexican children | Clinical and Translational Allergy | Full...
Median age 20 months (±12 months), 15 female (50%) 15 male(50%). IgA2 deficiency 16 (53%), IgG4 and IgA2 deficiencies 13 (43%), IgG4 deficiency 27 (90%), 29 patients had distal renal tubular acidosis (96%) 1 patient with proximal renal tubular acidosis. About food allergies, cows milk 28(93%), egg 18 (60%), wheat 0, corn 8 (26.6%), soy 2 (6.6%), non IgE mediated to cows milk 6 (20%), egg 6 (20%), soy 7 (23%), wheat 4 (13%), corn 1 (3.3%). The formula used to cows milk allergy was aminoacid based formula 19 (63.3%), extensively hydrolized formula 11 (36.6%). Gastroesophageal reflux was associated in 83.3%, wheezing 75%, diarrhea 33.3%, atopic dermatitis 25%, rhinitis 83.3%, urticaria 19.4%, constipaciòn 2.8%, blood stools 2.8%. ...
https://ctajournal.biomedcentral.com/articles/10.1186/2045-7022-1-S1-P111
Glue-sniffing and distal renal tubular acidosis: sticking to the facts. | American Society of NephrologyGlue-sniffing and distal renal tubular acidosis: sticking to the facts. | American Society of Nephrology
An index case is presented to introduce the subject of the acid-base and electrolyte abnormalities resulting from toluene abuse. These include metabolic acidosis associated with a normal anion gap and excessive loss of sodium and potassium in the urine. The major question addressed is, what is the basis for the metabolic acidosis? Overproduction of hippuric acid resulting from the metabolism of toluene plays a more important role in the genesis of the metabolic acidosis than was previously believed. This conclusion is supported by the observation that the rate of excretion of ammonium was not low during metabolic acidosis in six of eight patients, suggesting that distal renal tubular acidosis was not an important acid-base abnormality in most cases where ammonium was measured. The excretion of hippurate in the urine unmatched by ammonium also mandates an enhanced rate of excretion of the cations, sodium and potassium. The loss of sodium causes extracellular fluid volume contraction and a fall in ...
https://jasn.asnjournals.org/content/1/8/1019
Sjögrens syndrome presenting as hypokalemic paralysis due to distal renal tubular acidosis | Read by QxMDSjögrens syndrome presenting as hypokalemic paralysis due to distal renal tubular acidosis | Read by QxMD
A 57-year-old woman presented with a flaccid paralysis, muscle tenderness, and respiratory depression. Laboratory results demonstrated severe hypokalemia with hyperchloremic metabolic acidosis and abnormally acidified urine. The urinary anion gap was positive in the presence of acidemia, thus establishing the diagnosis of distal renal tubular acidosis (DRTA). The patient fully recovered after potassium and alkali replacement. Further investigation revealed Sjögrens syndrome as the underlying cause of DRTA ...
https://read.qxmd.com/read/8835579/sj%C3%A3-gren-s-syndrome-presenting-as-hypokalemic-paralysis-due-to-distal-renal-tubular-acidosis
A Novel Mutation in the Anion Exchanger 1 Gene Is Associated With Familial Distal Renal Tubular Acidosis and Nephrocalcinosis |...A Novel Mutation in the Anion Exchanger 1 Gene Is Associated With Familial Distal Renal Tubular Acidosis and Nephrocalcinosis |...
Objective. The anion exchanger gene (AE1) or band 3 encodes a chloride-bicarbonate (Cl−/HCO3−) exchanger expressed in the erythrocyte and in the renal α-intercalated cells involved in urine acidification. The purpose of the present study was to screen for mutations in the AE1 gene in 2 brothers (10 and 15 years of age) with familial distal renal tubular acidosis (dRTA), nephrocalcinosis, and failure to thrive.. Methods. AE1 mutations were screened by single-strand conformation polymorphism, cloning, and sequencing.. Results. A complete form of dRTA was confirmed in the 2 affected brothers and an incomplete form in their father. All 3 were heterozygous for a novel 20-bp deletion in exon 20 of the AE1 gene. This deletion resulted in 1 mutation in codon 888 (Ala-888→Leu) followed by a premature termination codon at position 889, truncating the protein by 23 amino acids. As band 3 deficiency might lead to spherocytic hemolytic anemia or ovalocytosis, erythrocyte abnormalities were also ...
https://pediatrics.aappublications.org/content/112/6/1361
Renal Tubular Acidosis with Hypokalaemic Paralysis and Nephrolitiasis [Medeniyet Med J]
between attacks distinguish periodic paralysis from other causes (2). The presence of type 1 RTA should be considered in any patient with a normal anion gap metabolic acidosis and an inappropriate high urine pH (3). The complications to renal tubular acidosis including hypokalaemic muscle paralysis or chronic muscle weakness, nephrolitiasis, and osteomalacia can be avoided if the diagnosis of renal tubular ...
http://medeniyetmedicaljournal.org/jvi.aspx?pdir=medeniyet&plng=eng&un=MEDJ-27037&look4=
Renal tubular acidosis and osteopetrosis with carbonic anhydrase II deficiency: pathogenesis of impaired acidificationRenal tubular acidosis and osteopetrosis with carbonic anhydrase II deficiency: pathogenesis of impaired acidification
Renal tubular acidosis with osteopetrosis is an autosomal recessive disorder due to deficiency of carbonic anhydrase II (CAII). A 3.5-year-old Egyptian boy with osteopetrosis and cerebral calcification has a persistent normal anion gap type of metabolic acidosis (plasma pH 7.26) and a mild degree of …
https://pubmed.ncbi.nlm.nih.gov/9323296/?dopt=Abstract
Overview: What is primary distal renal tubular acidosis? | ThinkGeneticOverview: What is primary distal renal tubular acidosis? | ThinkGenetic
Primary distal renal tubular acidosis (primary dRTA) is a rare genetic condition that results in problems with kidney function, bone formation, hearing, and managing potassium, calcium, and pH levels in the body. The symptoms of primary dRTA most often appear in babies; however there are rarer form
https://www.thinkgenetic.com/diseases/primary-distal-renal-tubular-acidosis-109939/overview/66965
Renal tubular acidosis with deafness - NORD (National Organization for Rare Disorders)Renal tubular acidosis with deafness - NORD (National Organization for Rare Disorders)
Renal tubular acidosis with deafness is characterized by kidney (renal) problems and sensorineural hearing loss. Infants with this condition may have problems with feeding and gaining weight (failure to thrive). Most children and adults with the condition have short stature, and many develop kidney stones. Other less common features include a softening and weakening of the bones and hypokalemic paralysis (extreme muscle weakness associated with low levels of potassium in the blood). Renal tubular acidosis with deafness is caused by mutations in the ATP6V1B1 or ATP6V0A4 gene. It is inherited in an autosomal recessive pattern.[9495] Treatment with sodium bicarbonate or sodium citrate can reduce or prevent many of the symptoms of this condition.[9496]. For more information, visit GARD. ...
https://rarediseases.org/gard-rare-disease/renal-tubular-acidosis-with-deafness/
Failure to thrive in children with primary distal type renal tubular acidosis<...
TY - JOUR. T1 - Failure to thrive in children with primary distal type renal tubular acidosis. AU - Chang, Chia Yau. AU - Lin, Ching Yuang. PY - 2002/11/1. Y1 - 2002/11/1. N2 - Primary distal type renal tubular acidosis (RTA-type1) results from defects of distal renal tubules in urinary acidification. In attempt to evaluate the clinical features, growth and outcome of primary distal type RTA in Taiwan, we retrospectively studied 28 patients (16 males and 12 females) of primary distal type RTA in our hospital in the past 13 years. The mean age at diagnosis was 2 years and 6.8 months old. Hematuria was found in 5 out of 25 cases (20%). Nephrocalcinosis was found in 5 out of 21 cases (23.8%). The mean value of Uca/Ucr was 0.313±0.067 in those older than 2 years and 0.262±0.152 in those younger than 2 years. Rickets was suspected in only one child by radiologic study. At initial diagnosis, the mean bone age was delayed for 16 months. The older the patient was, the more delayed was the bone age. ...
https://tmu.pure.elsevier.com/zh/publications/failure-to-thrive-in-children-with-primary-distal-type-renal-tubu
Severe metabolic alkalosis due to diuretic treatment in a patient with distal renal tubular acidosis: a rare association ...Severe metabolic alkalosis due to diuretic treatment in a patient with distal renal tubular acidosis: a rare association ...
Introduction: Distal renal tubular acidosis is a rare genetic disease, characterised by deficit in renal tubular transport. Clinical features are metabolic acidosis with hypercloraemia and hypokalemia, and inability in urine acidification. Hypercalciuria may also be present, often treated with the use of a diuretic therapy with thiazides. Case Presentation: We present a severe disease onset in a neonate with consanguineous parents, both autosomal-recessive for an ATP6VOA4 gene mutation, and a nevertheless severe episode of metabolic alkalosis, occurred in the same patient after few months, during the diuretic therapy. Conclusion: Biochemical results lead us to hypothesize a susceptibility to the treatment that need further investigations. ...
https://mattioli1885journals.com/index.php/actabiomedica/article/view/6886
Autosomal Dominant Distal Renal Tubular Acidosis Overview | MediFindAutosomal Dominant Distal Renal Tubular Acidosis Overview | MediFind
Find everything you need to know about Autosomal Dominant Distal Renal Tubular Acidosis including experts, recent advances, and ongoing clinical trials.
https://www.medifind.com/conditions/autosomal-dominant-distal-renal-tubular-acidosis/4598
Complete distal renal tubular acidosis: Biochemical profile of a case<...
TY - JOUR. T1 - Complete distal renal tubular acidosis: Biochemical profile of a case. AU - Rajpurohit, Surendra Kumar. AU - Pendse, AK. AU - Ahmed, A. AU - Singh, PP. PY - 1992. Y1 - 1992. M3 - Article. VL - 7. SP - 205. EP - 206. JO - Indian Journal of Clinical Biochemistry. JF - Indian Journal of Clinical Biochemistry. SN - 0970-1915. IS - 2. ER - ...
https://augusta.pure.elsevier.com/en/publications/complete-distal-renal-tubular-acidosis-biochemical-profile-of-a-c
Distal Renal Tubular Acidosis with Grade 4 Vesicoureteral Reflux in a Child with Single KidneyDistal Renal Tubular Acidosis with Grade 4 Vesicoureteral Reflux in a Child with Single Kidney
Introduction Renal tubular acidosis (RTA) is a non-uremic defects of urinary acidification. It is characterized by a normal anion gap hyperchloremic met ...
https://en.civilica.com/doc/940492/
Renal Tubular Acidosis (RTA)-Causes-Types-Diagnosis-Treatment-ComplicationsRenal Tubular Acidosis (RTA)-Causes-Types-Diagnosis-Treatment-Complications
Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of the urine lower than normal. Renal tubular acidosis causes include Addison s disease, drugs, mineralcorticoid deficiency.
http://www.medindia.net/patients/patientinfo/renal-tubular-acidosis.htm
Distal Renal Tubular Acidosis | Animal Specialty Group
VETERINARY CASE STUDY: Renal tubular acidosis (RTA) is a group of rare disorders that lead to metabolic acidosis with normal anion gap. In dogs, cases are often idiopathic, whereas in cats, dRTA has been associated with pyelonephritis and hepatic lipidosis
https://asgvets.com/distal-renal-tubular-acidosis-in-a-terrier-presented-for-dehydration-lethargy-and-hepatopathy/
The Diet Pill and the Deadly Acidosis - Renal Fellow NetworkThe Diet Pill and the Deadly Acidosis - Renal Fellow Network
So, how does topiramate cause hyperchloremic normal anion gap metabolic acidosis? Carbonic anhydrase (CA) catalyzes the conversion of CO2 to HCO3- and H+ ion in the proximal tubule and in the type A intercalated cell of the cortical collecting duct. CAII is the most predominant isoform of CA present in the kidneys.Topimarate has been shown to inhibit the CAII activity thereby causing increased excretion of filtered bicarbonate leading to proximal renal tubular acidosis and impairment of the distal acidification leading to distal renal tubular acidosis. Patients with topimarate induced metabolic acidosis therefore tend to have an alkaline urine, positive urine anion gap, low urinary citrate levels indicating distal renal tubular impairment and increased fractional excretion of bicarbonate with elevated B2 microglobulinuria suggesting proximal tubular impairment ...
https://www.renalfellow.org/2011/03/16/diet-pill-and-deadly-acidosis/
Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis -...Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis -...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
https://clinicaltrials.gov/ct2/show/NCT01690039?cond=%22Renal+tubular+acidosis%22&rank=2
A Pediatric Case of Long-term Untreated Distal Renal Tubular AcidosisA Pediatric Case of Long-term Untreated Distal Renal Tubular Acidosis
The patient had typical biochemical findings of RTA, including metabolic acidosis with a normal anion gap and hypokalemia. Additional findings of alkaline urine, positive urine anion gap, nephrocalcinosis, and rickets suggested that the patient had dRTA. The patient also had growth retardation with severe bony deformities and muscle weakness.. In children, dRTA is almost always observed as a primary entity with underlying genetic causes, and at least three genes are known to cause primary dRTA: ATP6V1B1, ATP6V0A4, and SLC4A1 [4,5]. ATP6V1B1 and ATP6V0A4 encode the B1 and A4 subunits of the apical H+-ATPase pump, that is, the proton pump, in α-intercalated cells, respectively, and mutations in these genes cause autosomal recessive (AR) forms of dRTA with or without sensorineural hearing loss [6,7]. In a recent large multicenter study by the European dRTA Consortium, the prevalence of hearing loss was 88% in patients with ATP6V1B1 mutations and 36% in patients with ATP6V0A4 mutations [8]. SLC4A1 ...
http://chikd.org/journal/view.php?viewtype=pubreader&number=733
Renal tubular acidosis - WikipediaRenal tubular acidosis - Wikipedia
Renal tubular acidosis (RTA) is a medical condition that involves an accumulation of acid in the body due to a failure of the kidneys to appropriately acidify the urine. In renal physiology, when blood is filtered by the kidney, the filtrate passes through the tubules of the nephron, allowing for exchange of salts, acid equivalents, and other solutes before it drains into the bladder as urine. The metabolic acidosis that results from RTA may be caused either by failure to reabsorb sufficient bicarbonate ions (which are alkaline) from the filtrate in the early portion of the nephron (the proximal tubule) or by insufficient secretion of hydrogen ions (which are acidic) into the latter portions of the nephron (the distal tubule). Although a metabolic acidosis also occurs in those with renal insufficiency, the term RTA is reserved for individuals with poor urinary acidification in otherwise well-functioning kidneys. Several different types of RTA exist, which all have different syndromes and ...
https://en.wikipedia.org/wiki/Renal_tubular_acidosis
Renal Tubular AcidosisRenal Tubular Acidosis
Article Translations: (Spanish). Each time our internal organs do something, such as digesting food or healing damaged tissue, chemical reactions take place in the bodys cells. These reactions cause acid to go into the bloodstream.. Normally, the kidneys remove excess acid from blood, but certain diseases, genetic defects, or drugs can damage a kidneys ability to do this important job. This can allow too much acid to build up in the blood and cause problems. When this happens, its called renal tubular acidosis (RTA).. Without treatment, RTA can affect a childs growth and cause kidney stones, fatigue, muscle weakness, and other symptoms. Over time, untreated acidosis can lead to long-term problems like bone disease, kidney disease, and kidney failure.. Fortunately, such complications are rare, since most cases of RTA can be effectively treated with medicines or by treating the condition thats causing the acid to build up. ...
https://www.childrensmn.org/educationmaterials/parents/article/14611/renal-tubular-acidosis/
Sjögren syndrome presenting with hypopotassemic periodic paralysis due to renal tubular acidosis - Get your full text copy in...Sjögren syndrome presenting with hypopotassemic periodic paralysis due to renal tubular acidosis - Get your full text copy in...
Sjögren syndrome presenting with hypopotassemic periodic paralysis due to renal tubular acidosis - Get your full text copy in PDF #883326
https://www.amjcaserep.com/download/index/idArt/883326
Renal Tubular Acidosis (RTA) - Kidney and Urinary Tract Disorders - Merck Manuals Consumer VersionRenal Tubular Acidosis (RTA) - Kidney and Urinary Tract Disorders - Merck Manuals Consumer Version
Renal Tubular Acidosis (RTA) - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - Medical Consumer Version.
https://www.merckmanuals.com/home/kidney-and-urinary-tract-disorders/disorders-of-kidney-tubules/renal-tubular-acidosis-rta
Renal Tubular Acidosis Causes, Symptoms, Treatment in India | Medanta | MedantaRenal Tubular Acidosis Causes, Symptoms, Treatment in India | Medanta | Medanta
Renal tubular acidosis is accumulation of acid in the body due to a failure of the kidneys to acidify the urine. Call +91-124-4141414 to know more about its symptoms, causes, risk and prevention of renal tubular.
https://www.medanta.org/kidney-hospital/disease/renal-tubular-acidosis/
Valeria B. - Renal Tubular Acidosis Story | Childrens PittsburghValeria B. - Renal Tubular Acidosis Story | Childrens Pittsburgh
Valeria suffered from renal tubular acidosis. Read about her complex diagnosis and experience at Childrens Hospital of Pittsburgh of UPMC.
https://www.chp.edu/international-services/patient-stories/valeria-gallindo-bandes
Difference between revisions of Renal tubular acidosis - WikEMDifference between revisions of Renal tubular acidosis - WikEM
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock. Renal Tubular Acidosis Syndromes. South Med J. 2000;93(11). http://www.medscape.com/viewarticle/410658 ...
https://www.wikem.org/w/index.php?title=Renal_tubular_acidosis&diff=next&oldid=84599
Renal tubular acidosis - WikEMRenal tubular acidosis - WikEM
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock. Renal Tubular Acidosis Syndromes. South Med J. 2000;93(11). http://www.medscape.com/viewarticle/410658 ...
https://www.wikem.org/w/index.php?title=Renal_tubular_acidosis&oldid=84599&printable=yes
Emergency Central | Renal tubular acidosisEmergency Central | Renal tubular acidosis
Renal tubular acidosis was found in Emergency Central. Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Daviss Drug, McGraw-Hill Medicals Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals.
https://emergency.unboundmedicine.com/emergency/search?q=Renal%20tubular%20acidosis
Unraveling the Molecular Pathogenesis of Isolated Proximal Renal Tubular Acidosis | American Society of NephrologyUnraveling the Molecular Pathogenesis of Isolated Proximal Renal Tubular Acidosis | American Society of Nephrology
Basolateral transport of HCO3− in the proximal tubules is mediated predominantly by kNBC1; inactivating mutations in the kNBC1 transcript can therefore account for the renal phenotype in this disorder. The ocular abnormalities can also be ascribed to inactivating mutations in the NBC gene. The ocular abnormalities can also be ascribed to inactivating mutations in the NBC gene. The presence of sodium bicarbonate cotransport activity has been detected in several ocular tissues (44-46), although the molecular basis of this transport has not been established. We demonstrated that human corneal endothelial cells express both kNBC1 and pNBC1 mRNA (47). Using isoform-specific antibodies, we further established that both kNBC1 and pNBC1 protein are expressed in several ocular tissues such as corneal endothelium, trabecular meshwork, and lens epithelium (48). In addition, adenovirus-mediated delivery of a specific hammerhead ribozyme against NBC to human lens epithelial cells largely suppressed NBC ...
https://jasn.asnjournals.org/content/13/8/2171?ijkey=b8194c412cc3a783c9be08b7188e5bbb30542292&keytype2=tf_ipsecsha
A Novel Mutation in the Anion Exchanger 1 Gene Is Associated With Familial Distal Renal Tubular Acidosis and Nephrocalcinosis |...A Novel Mutation in the Anion Exchanger 1 Gene Is Associated With Familial Distal Renal Tubular Acidosis and Nephrocalcinosis |...
Familial forms of distal RTA have been described since 1968,35 but it was only after 1997 that both dominant4,5,29 and recessive7,8,11 autosomal forms were associated with AE1 mutations. In the present investigation, complete dRTA and NC were detected in 2 brothers and incomplete dRTA with nephrolithiasis in their father. The similar clinical course observed in the 2 brothers led us to hypothesize that a genetic cause of the disorder should be sought.. In the present study, the affected brothers and their father shared a 20-bp deletion in exon 20 of the AE1 gene or Band 3 (Band 3 Dourados), resulting in a premature termination codon at position 889, truncating the protein by 23 amino acids. The deletion at the C-terminal tail was responsible for the double band evidenced by agarose gel electrophoresis of the exon 20 PCR product of the brothers and their father, 1 with 267 and 1 with 247 bp (without 20 bp) instead of the single 267-bp band.. The structure and function of the short C-terminal ...
https://pediatrics.aappublications.org/content/112/6/1361?ijkey=85dee70647b0246cd7af1da84cd841310b31bfe1&keytype2=tf_ipsecsha
Normal Anion Gap Metabolic Acidosis | DiabetesTalk.NetNormal Anion Gap Metabolic Acidosis | DiabetesTalk.Net
(Video) Overview of Acid-Base Maps and Compensatory Mechanisms By James L. Lewis, III, MD, Attending Physician, Brookwood Baptist Health and Saint Vincents Ascension Health, Birmingham Metabolic acidosis is primary reduction in bicarbonate (HCO3−), typically with compensatory reduction in carbon dioxide partial press
https://diabetestalk.net/ketosis/normal-anion-gap-metabolic-acidosis
RePub, Erasmus University Repository: Distal renal tubular acidosis with multiorgan autoimmunity: A case reportRePub, Erasmus University Repository: Distal renal tubular acidosis with multiorgan autoimmunity: A case report
A 61-year-old woman with a history of pernicious anemia presented with progressive muscle weakness and dysarthria. Hypokalemic paralysis (serum potassium, 1.4 mEq/L) due to distal renal tubular acidosis (dRTA) was diagnosed. After excluding several possible causes, dRTA was considered autoimmune. However, the patient did not meet criteria for any of the autoimmune disorders classically associated with dRTA. She had very high antibody titers against parietal cells, intrinsic factor, and thyroid peroxidase (despite normal thyroid function). The patient consented to a kidney biopsy, and acid-base transporters, anion exchanger type 1 (AE1), and pendrin were undetectable by immunofluorescence. Indirect immunofluorescence detected diminished abundance of AE1- and pendrin-expressing intercalated cells in the kidney, as well as staining by the patients serum of normal human intercalated cells and parietal cells expressing the adenosine triphosphatase hydrogen/potassium pump ...
https://repub.eur.nl/pub/90176
Metabolic acidosis, normal anion gap | DiagnosaurusMetabolic acidosis, normal anion gap | Diagnosaurus
Metabolic acidosis, normal anion gap answers are found in the Diagnosaurus powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
https://www.unboundmedicine.com/5minute/view/Diagnosaurus/114290/all/Metabolic_acidosis__normal_anion_gap
JCI - Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1JCI - Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1
While macro- and microscopic kidney development appear to proceed normally in mice that lack Foxi1, electron microscopy reveals an altered ultrastructure of cells lining the distal nephron. Northern blot analyses, cRNA in situ hybridizations, and immunohistochemistry demonstrate a complete loss of expression of several anion transporters, proton pumps, and anion exchange proteins expressed by intercalated cells of the collecting ducts, many of which have been implicated in hereditary forms of distal renal tubular acidosis (dRTA). In Foxi1-null mutants the normal epithelium with its two major cell types - principal and intercalated cells - has been replaced by a single cell type positive for both principal and intercalated cell markers. To test the functional consequences of these alterations, Foxi1-/- mice were compared with WT littermates in their response to an acidic load. This revealed an inability to acidify the urine as well as a lowered systemic buffer capacity and overt acidosis in null ...
https://www.jci.org/articles/view/20665/figure/1
Distal Renal Tubular Acidosis and Diabetes Insipidus Leading to the Diagnosis Of Sjögrens Syndrome by Loheetha Ragupathi, MD...Distal Renal Tubular Acidosis and Diabetes Insipidus Leading to the Diagnosis Of Sjögrens Syndrome by Loheetha Ragupathi, MD...
INTRODUCTION Sjögrens syndrome is a chronic inflammatory disease characterized by the infiltration and progressive destruction of salivary and lacrimal glands. A common presentation involves the complaints of dry eyes and dry mouth, known as the
http://jdc.jefferson.edu/tmf/vol17/iss1/15/
Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1
While macro- and microscopic kidney development appear to proceed normally in mice that lack Foxi1, electron microscopy reveals an altered ultrastructure of cells lining the distal nephron. Northern blot analyses, cRNA in situ hybridizations, and immunohistochemistry demonstrate a complete loss of e …
https://pubmed.ncbi.nlm.nih.gov/15173882/?dopt=Abstract
Autosomal dominant distal renal tubular acidosis - Rare Infectious Disease NewsAutosomal dominant distal renal tubular acidosis - Rare Infectious Disease News
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom. ...
https://www.rareidnews.com/rarediseases/autosomal-dominant-distal-renal-tubular-acidosis/
Distal renal tubular acidosisDistal renal tubular acidosis
Logical Images, Inc. d/b/a VisualDx (hereinafter VisualDx, we, us, or our) has created this Acceptable Use Policy, Medical Disclaimer, & Copyright Notice (this Notice) to inform you (hereinafter you, your, or yourself) as a purchaser of a license for and/or user of the software hosted by VisualDx known as VisualDx (the Software) of certain important terms and conditions set forth in the VisualDx End User License Agreement that governs your license for and/or use of the Software (the EULA). This Notice is subject to all of the terms and conditions set forth in the EULA and does not replace or limit it in anyway. You should read the EULA in detail prior to purchasing a license for or using the Software to make sure you understand and agree to its terms and conditions. Nothing in this Notice will (a) expand your rights or VisualDx′s obligations under the EULA or (b) modify or otherwise affect any terms and conditions of the EULA or the rights of the parties under the EULA. In ...
https://www.visualdx.com/visualdx/diagnosis/distal%20renal%20tubular%20acidosis?diagnosisId=55040&moduleId=101
Renal tubular acidosis - Clinical AdvisorRenal tubular acidosis - Clinical Advisor
First, confirm that that patient has a non-anion gap metabolic acidosis:. 1. Note a low serum bicarbonate concentration.. 2. Rule out a gap acidosis by checking that the serum anion gap is normal.. 3. Check a blood gas to rule out a respiratory alkalosis with accompanying renal compensation as an explanation for the low bicarbonate concentration.. Once the finding of non-anion gap metabolic acidosis is confirmed:. 4. Check for the presence of clinical clues:. History of diarrhea suggests stool bicarbonate loss (urine anion gap should be negative). See below.. Chronic or acute kidney disease suggested by elevated serum Cr or low calculated CrCl.. Check for use of relevant medications: Amiloride: prevents distal Na resorption by competing for distal sodium channels impairing excretion of H+ and K+. Often seen with accompanying hyperkalemia.. Carbonic anhydrase inhibitors: Prevents proximal resorption of bicarbonate. Accompanying hypokalemia and high urine ...
https://www.clinicaladvisor.com/home/decision-support-in-medicine/hospital-medicine/renal-tubular-acidosis/
Topiramate induces type 3 renal tubular acidosis by inhibiting renal carbonic anhydrase. - Sacre AnneTopiramate induces type 3 renal tubular acidosis by inhibiting renal carbonic anhydrase. - Sacre Anne
en] Acidosis, Renal Tubular/chemically induced/enzymology ; Anticonvulsants/adverse effects/therapeutic use ; Carbonic Anhydrases/metabolism ; Female ; Fructose/adverse effects/analogs & derivatives/therapeutic use ; Humans ; Kidney/drug effects/enzymology/pathology ; Middle Aged ; Migraine Disorders/drug therapy ; Models, ...
http://orbi.ulg.ac.be/handle/2268/134987
BPB Reports
NBCe1 (electrogenic Na+/HCO3 - cotransporter 1) is a product of gene SLC4A4 and has five splice variants, NBCe1-A through NBCe1-E. In agreement with an essential role of NBCe1 in cellular pH regulation, human families carrying missense mutations of gene SLC4A4 show proximal renal tubular acidosis. Some of them exhibit brain function-related symptoms, such as migraine and mental retardation, but physiological roles of NBCe1 in brain function remain unclear. To gain insights into NBCe1-specific functions in the brain, we herein identified proteins that specifically bind to a unique C-terminal region of NBCe1-C, a brain-specific NBCe1 isoform. We found that a catalytic subunit of calcineurin binds to the C terminus of NBCe1-C in the mouse cerebellum. Heterologous-coexpression experiments revealed that calcineurin binds to NBCe1-C via a PQIRIE motif at its C terminus. The interaction enhanced cell surface expression of NBCe1-C, resulting in an increase of its transporter activity, for which the ...
https://www3.e-kenkyu.com/bpb-reports-online-journal/papers?number=1&volume=2&year=2019
Renal Tubular Acidosis - Kidney conditions - Condition | Our HealthRenal Tubular Acidosis - Kidney conditions - Condition | Our Health
Hi. I was diagnosed with RTA type 4 when I was 2 years old. My mom took me to a neurologist because I hadnt started walking yet. They did blood work, and found that my potassium was too high. So, I started going to a nephrologist. They found, through extensive blood work that what worked best for me was the medicine hyrdrochlorothiazide. I have to take this every day, or my potassium will go up. About five years ago, my brother was getting blood work done to see if he qualified for accutane, and they found that his potassium was dangerously high. He spent about a week in the hospital. They found he had a heart arrythmia. And he was finally diagnosed with pseudohyperaldosterone type1. It appears that this is a genetic abnormality within my family. I will be getting my 2 sons tested as well ...
http://www.ourhealth.com/conditions/kidney-conditions/renal-tubular-acidosis
Renal Tubular Acidosis | Renal Treatment Centers
Renal calculi can develop in any part of urinary tract but mostly found in renal pelvis or in calyces. Renal calculi are also known as kidney stones, these are solid crystals aggregation formed in the kidneys from the dietary minerals present in the urine. These stones are mainly located in the kidney, ureter, and bladder. Read more ...
http://renaltreatment.com/tag/renal-tubular-acidosis/
Renal Tubular AcidosisRenal Tubular Acidosis
This kidney problem causes acid levels in the blood to become too high, causing fatigue, muscle weakness, and other kidney problems. The condition is usually treatable.
http://kidshealth.org/KidsHealthDemo/en/parents/renal-tubular-acidosis.html
HyperaldosteronismHyperaldosteronism
The causes of secondary hyperaldosteronism are accessory renal veins, fibromuscular dysplasia, reninoma, renal tubular acidosis ... Rodriguez Soriano J, Boichis H, Stark H, Edelmann CM (1967). "Proximal renal tubular acidosis. A defect in bicarbonate ... Secondary hyperaldosteronism can also be caused by proximal renal tubular acidosis Secondary hyperaldosteronism can also be a ... Another is renal artery stenosis, in which the reduced blood supply across the juxtaglomerular apparatus stimulates the ...
https://en.wikipedia.org/wiki/Hyperaldosteronism
Kidney stone diseaseKidney stone disease
The formation of calcium phosphate stones is associated with conditions such as hyperparathyroidism and renal tubular acidosis ... Bailey & Love's/25th/1296 National Endocrine and Metabolic Diseases Information Service (2008). "Renal Tubular Acidosis (NIH ... such as distal renal tubular acidosis, Dent's disease, hyperparathyroidism, primary hyperoxaluria, or medullary sponge kidney. ... However, no renal tubular damage or visible deposition of calcium oxalate crystals in kidneys was found in yearling wether ...
https://en.wikipedia.org/wiki/Kidney_stone_disease
HyperkalemiaHyperkalemia
Karet, Fiona E. (February 2009). "Mechanisms in Hyperkalemic Renal Tubular Acidosis: Figure 1". Journal of the American Society ... However, in respiratory acidosis or organic acidosis such as lactic acidosis, the effect on serum potassium are much less ... Type IV renal tubular acidosis (aldosterone resistance of the kidney's tubules) Gordon's syndrome (pseudohypoaldosteronism type ... Metabolic acidosis can cause hyperkalemia as the elevated hydrogen ions in the cells can displace potassium, causing the ...
https://en.wikipedia.org/wiki/Hyperkalemia
Hepatocyte nuclear factor 4 alphaHepatocyte nuclear factor 4 alpha
Kashoor I, Batlle D (September 2019). "Proximal renal tubular acidosis with and without Fanconi syndrome". Kidney Research and ...
https://en.wikipedia.org/wiki/Hepatocyte_nuclear_factor_4_alpha
Wilfrid PayneWilfrid Payne
LIGHTWOOD, R.; PAYNE, W. W.; BLACK, J. A. (1 December 1953). "Infantile Renal Acidosis". Pediatrics. American Academy of ... Payne, Wilfrid W. (1956). "Renal tubular defects in childhood". Pediatrics. American Academy of Pediatrics. 17 (1): 84-92. ISSN ... "Wilfrid Walter Payne". The Renal Association. Renal Association. Retrieved 27 June 2018. "Wilfrid Walter Payne". Munks Roll - ...
https://en.wikipedia.org/wiki/Wilfrid_Payne
Lightwood-Albright syndromeLightwood-Albright syndrome
... is a neonatal form of renal tubular acidosis. It is characterized by distal renal tubular acidosis ... This, along with the inability to excrete other acids in the body, contribute to metabolic acidosis and renal tubular acidosis ... Fanconi G (February 1954). "Tubular Insufficiency and Renal Dwarfism". Archives of Disease in Childhood. 29 (143): 1-6. doi: ... Laboratory findings can include metabolic acidosis, hyperchloremia, hypercalcemia, and elevated urinary pH. Specifically, the ...
https://en.wikipedia.org/wiki/Lightwood–Albright_syndrome
Southeast Asian ovalocytosisSoutheast Asian ovalocytosis
... distal renal tubular acidosis, and Southeast Asian ovalocytosis". Kidney International. 62 (1): 10-19. doi:10.1046/j.1523- ...
https://en.wikipedia.org/wiki/Southeast_Asian_ovalocytosis
CLDN16CLDN16
Manz F, Schärer K, Janka P, Lombeck J (1978). "Renal magnesium wasting, incomplete tubular acidosis, hypercalciuria and ... Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with ... a renal tight junction protein required for paracellular Mg2+ resorption". Science. 285 (5424): 103-6. doi:10.1126/science. ...
https://en.wikipedia.org/wiki/CLDN16
Electrogenic sodium bicarbonate cotransporter 1Electrogenic sodium bicarbonate cotransporter 1
Other mutations disrupt kidney bicarbonate transport and cause proximal renal tubular acidosis. NBCe1-A aka kNBC1 (mainly ... 1999). "Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities". Nat. Genet. 23 ... "Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis". J. Biol. ... 2003). "Localization of NBC-1 variants in human kidney and renal cell carcinoma". Biochem. Biophys. Res. Commun. 310 (4): 1213- ...
https://en.wikipedia.org/wiki/Electrogenic_sodium_bicarbonate_cotransporter_1
Fuller AlbrightFuller Albright
Known for Lightwood-Albright syndrome, a neonatal form of renal tubular acidosis. In 1941 Albright was elected a Fellow of the ... and renal tubular acidosis (inability of the kidneys to regulate the acid-base balance in the body), and recognized the ...
https://en.wikipedia.org/wiki/Fuller_Albright
Carbonic anhydrase IICarbonic anhydrase II
Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the ... Carbonic anhydrase II deficiency syndrome (osteopetrosis associated with renal tubular acidosis and cerebral calcification)". ... recessive osteopetrosis with renal tubular acidosis and cerebral calcification". Pediatrics. 77 (3): 371-81. doi:10.1542/peds. ...
https://en.wikipedia.org/wiki/Carbonic_anhydrase_II
Oliver WrongOliver Wrong
A key insight was that in the group of diseases termed 'Renal Tubular Acidosis' (RTA), urinary excretion of ammonium was ... 2012). "Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients". QJM. 105 (9): 861-877. ... 2012). "Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients". QJM. 105 (9): 861-877. ... Unwin, RJ (2012). "Back to the future: renal tubular acidosis then and now". QJM. 105 (9): 915-916. doi:10.1093/qjmed/hcs134. ...
https://en.wikipedia.org/wiki/Oliver_Wrong
ATP6V1B1ATP6V1B1
"Entrez Gene: ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (Renal tubular acidosis with deafness)". Human ... Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. GRCh38: Ensembl release 89: ... "Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness". Nat Genet. 21 ...
https://en.wikipedia.org/wiki/ATP6V1B1
Fanconi syndromeFanconi syndrome
The loss of bicarbonate results in type 2 or proximal renal tubular acidosis. The loss of phosphate results in the bone ... The clinical features of proximal renal tubular acidosis are:[citation needed] Polyuria, polydipsia and dehydration ... renal tubular acidosis in a patient with primary Sjögren's syndrome with monoclonal gammopathy of undetermined significance". ... Growth failure Acidosis Hypokalemia Hyperchloremia Other features of the generalized proximal tubular dysfunction of the ...
https://en.wikipedia.org/wiki/Fanconi_syndrome
Vici syndromeVici syndrome
In 2007 the renal tubular acidosis was another clinical complication described in only one case report of two brothers with ... 2007) "Sibling cases of Vici syndrome: sleep abnormalities and complications of renal tubular acidosis". Am J Med Genet A 143(2 ... Renal abnormalities (15%) Infections of the gastrointestinal and urinary tracts are common. Swallowing and feeding difficulties ...
https://en.wikipedia.org/wiki/Vici_syndrome
PotassiumPotassium
... citrate is used to treat a kidney stone condition called renal tubular acidosis. Potassium, in the form of potassium ... at most as a result of prompt and efficient clearance by both renal and extra-renal mechanisms. Hypokalemia, a deficiency of ... Renal handling of potassium is closely connected to sodium handling. Potassium is the major cation (positive ion) inside animal ... Since only 1-10 g of sodium and 1-4 g of potassium are likely to be replaced by diet, renal filtering must efficiently reabsorb ...
https://en.wikipedia.org/wiki/Potassium
SLC12A7SLC12A7
Boettger T, Hübner CA, Maier H, Rust MB, Beck FX, Jentsch TJ (April 2002). "Deafness and renal tubular acidosis in mice lacking ...
https://en.wikipedia.org/wiki/SLC12A7
ATP6V0A4ATP6V0A4
Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. ATP6V0A4 has been shown to ... cause recessive distal renal tubular acidosis with preserved hearing". Nat. Genet. 26 (1): 71-5. doi:10.1038/79208. PMID ... "Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34". Am. J. ...
https://en.wikipedia.org/wiki/ATP6V0A4
Inner ear regenerationInner ear regeneration
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. Nature, 416(6883), 874-878. https://doi.org/ ...
https://en.wikipedia.org/wiki/Inner_ear_regeneration
LaxativeLaxative
For example, severe hypokalaemia has been associated with distal renal tubular acidosis from laxative abuse. Metabolic ... Copeland PM; Molina, H.; Ohye, Ch.; MacIas, R.; Alaminos, A.; Alvarez, L.; Teijeiro, J.; Muñoz, J.; Ortega, I. (1994). "Renal ... Wright LF, DuVal JW (1987). "Renal injury associated with laxative abuse". South Med J. 80 (10): 1304-6. doi:10.1097/00007611- ...
https://en.wikipedia.org/wiki/Laxative
IfosfamideIfosfamide
... may also cause a normal anion gap acidosis, specifically renal tubular acidosis type 2. "Ifosfamide". The American ...
https://en.wikipedia.org/wiki/Ifosfamide
Expiration dateExpiration date
A rare exception is a case of renal tubular acidosis purportedly caused by expired tetracycline. A study conducted by the U.S. ...
https://en.wikipedia.org/wiki/Expiration_date
Tyrosinemia type ITyrosinemia type I
Renal tubular acidosis, hypophosphatemia and aminoaciduria. Cardiomyopathy, neurologic and dermatologic manifestations are also ... SA can function to inhibit renal tubular function, the synthesis of heme, and the immune system. The accumulation of ... The inability of cells to process tyrosine can lead to chronic liver damage ending in liver failure, as well as renal disease ... Kidney failure is a potential result of impaired kidney function, but the most common symptom associated with renal dysfunction ...
https://en.wikipedia.org/wiki/Tyrosinemia_type_I
Shelf lifeShelf life
A rare exception is a case of renal tubular acidosis purportedly caused by expired tetracycline. A study conducted by the U.S. ...
https://en.wikipedia.org/wiki/Shelf_life
WNK4WNK4
... hypertension and systemic acidosis without renal failure associated with a tubular defect in potassium excretion". The American ... Renal Physiology. 305 (1): F31-41. doi:10.1152/ajprenal.00652.2012. PMC 3725674. PMID 23594824. Ring AM, Leng Q, Rinehart J, ... Renal Physiology. 290 (6): F1305-14. doi:10.1152/ajprenal.00391.2005. PMID 16403833. Jiang Y, Ferguson WB, Peng JB (February ... Renal Physiology. 304 (1): F8-F18. doi:10.1152/ajprenal.00284.2012. PMC 3543615. PMID 23054253. San-Cristobal P, Pacheco- ...
https://en.wikipedia.org/wiki/WNK4
Pyruvate dehydrogenase deficiencyPyruvate dehydrogenase deficiency
"Metabolic Acidosis Treatment & Management: Approach Considerations, Type 1 Renal Tubular Acidosis, Type 2 Renal Tubular ... patients usually show severe hyperventillation due to profound metabolic acidosis mostly related to lactic acidosis. Metabolic ... Resolution of lactic acidosis is observed in patients with E1 alpha enzyme subunit mutations that reduce enzyme stability. ... It is expected that most cases will be of mild severity and have a clinical presentation involving lactic acidosis. Male ...
https://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_deficiency
V-ATPaseV-ATPase
There are four types of renal tubular acidosis. Type 1 is distal renal tubular acidosis and results from a failure of the ... In all cases, renal tubular acidosis results from a failure of the normal renal mechanisms that regulate systemic pH. ... January 1999). "Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness ... One gene is carbonic anhydrase II (CAII), which, when mutated, causes osteopetrosis with renal tubular acidosis(type 3). ...
https://en.wikipedia.org/wiki/V-ATPase
Enlarged vestibular aqueductEnlarged vestibular aqueduct
... s can also occur in branchio-oto-renal syndrome, CHARGE syndrome and renal tubular acidosis. ...
https://en.wikipedia.org/wiki/Enlarged_vestibular_aqueduct
HydrochlorothiazideHydrochlorothiazide
Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those ... renal tubular acidosis. It is also used for the prevention of kidney stones in those who have high levels of calcium in their ...
https://en.wikipedia.org/wiki/Hydrochlorothiazide
Band 3 anion transport proteinBand 3 anion transport protein
... renal tubular acidosis, which is an inability to acidify the urine, even if the blood is too acidic. These mutations are ... exchanger associated with inherited distal renal tubular acidosis". Clin. Exp. Nephrol. 8 (1): 1-11. doi:10.1007/s10157-003- ...
https://en.wikipedia.org/wiki/Band_3_anion_transport_protein
നെഫ്രോട്ടിക് സിൻഡ്രോം - വിക്കിപീഡിയനെഫ്രോട്ടിക് സിൻഡ്രോം - വിക്കിപീഡിയ
Renal tubular acidosis *proximal. *distal. *Acute tubular necrosis. *Genetic *Fanconi syndrome. *Bartter syndrome ...
https://ml.wikipedia.org/wiki/നെഫ്രോട്ടിക്_സിൻഡ്രോം
AspirinAspirin
... is known to compete with penicillin G for renal tubular secretion.[211] Aspirin may also inhibit the absorption of ... Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.[52] ... A 10- to 20-fold increase in renal clearance occurs when urine pH is increased from 5 to 8. The use of urinary alkalinization ... D'Agati V (July 1996). "Does aspirin cause acute or chronic renal failure in experimental animals and in humans?". American ...
https://en.m.wikipedia.org/wiki/Aspirin
Lynn GilderdaleLynn Gilderdale
... renal tubular acidosis type 1, osteoporosis, to name but a few ] and she started to say to me in her sign language, 'Mum, you ...
https://en.wikipedia.org/wiki/Lynn_Gilderdale
NephronNephron
... renal tubular diseases include acute tubular necrosis, renal tubular acidosis, and polycystic kidney disease. Distribution of ... It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a ... 1027 The renal corpuscle has two poles: a vascular pole and a tubular pole.: 397 The arterioles from the renal circulation ... renal tubular diseases include acute tubular necrosis and polycystic kidney disease. The nephron is the functional unit of the ...
https://en.wikipedia.org/wiki/Nephron
Oculocerebrorenal syndromeOculocerebrorenal syndrome
Lowe syndrome can be considered a cause of Fanconi syndrome (bicarbonaturia, renal tubular acidosis, potassium loss and sodium ... This problem is known as Fanconi-type renal tubular dysfunction.[medical citation needed] This syndrome is caused by mutations ... proximal tubular acidosis, aminoaciduria and low-molecular-weight proteinuria. ... Renal pathology is characterized by an abnormal loss of certain substances into the urine, including bicarbonate, sodium, ...
https://en.wikipedia.org/wiki/Oculocerebrorenal_syndrome
BCS1LBCS1L
... renal tubulopathy, muscle weakness, exercise intolerance, lactic acidosis, hypotonia, seizures, and optic atrophy. Pathogenic ... which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L". Journal of Cell Science. 121 (Pt 15 ... Growth retardation, aminoaciduria, cholestasis, iron overload, lactic acidosis, and early death (GRACILE) is a recessively ... GRACILE is characterized by fetal growth retardation, lactic acidosis, aminoaciduria, cholestasis, and abnormalities in iron ...
https://en.wikipedia.org/wiki/BCS1L
MetforminMetformin
Somogyi A, Stockley C, Keal J, Rolan P, Bochner F (May 1987). "Reduction of metformin renal tubular secretion by cimetidine in ... Lactic acidosis almost never occurs with metformin exposure during routine medical care. Rates of metformin-associated lactic ... It is cleared from the body by tubular secretion and excreted unchanged in the urine; it is undetectable in blood plasma within ... Renal Physiology. 310 (5): F342-50. doi:10.1152/ajprenal.00204.2015. PMID 26661649. Witters LA (October 2001). "The blooming of ...
https://en.wikipedia.org/wiki/Metformin
Malignant infantile osteopetrosisMalignant infantile osteopetrosis
Neuropathic infantile osteopetrosis Infantile osteopetrosis with renal tubular acidosis Infantile osteopetrosis with ...
https://en.wikipedia.org/wiki/Malignant_infantile_osteopetrosis
Charles II of SpainCharles II of Spain
Charles may have had combined pituitary hormone deficiency and distal renal tubular acidosis. One suggestion is his health ...
https://en.wikipedia.org/wiki/Charles_II_of_Spain
Tiny Tim (A Christmas Carol)Tiny Tim (A Christmas Carol)
However, renal tubular acidosis (type 1), which is a type of kidney failure causing the blood to become acidic, has been ...
https://en.wikipedia.org/wiki/Tiny_Tim_(A_Christmas_Carol)
Acid-base homeostasisAcid-base homeostasis
When the extracellular fluids tend towards acidity, the renal tubular cells secrete the H+ ions into the tubular fluid from ... metabolic acidosis, respiratory acidosis, metabolic alkalosis, and respiratory alkalosis. One or a combination of these ... It is very probable that the renal tubular cells of the distal convoluted tubules are themselves sensitive to the pH of the ... are deaminated by the distal renal tubular epithelial cells. Thus some of the "acid content" of the urine resides in the ...
https://en.wikipedia.org/wiki/Acid–base_homeostasis
List of skin conditionsList of skin conditions
Hemorrhagic fever with renal syndrome Hepatitis B Hepatitis C Herpangina Herpes gladiatorum (scrum pox) Herpes simplex Herpes ... tubular apocrine adenoma) Papillary hidradenoma (hidradenoma papilliferum) Papillomatosis cutis carcinoides (Gottron's ... Mitochondrial myopathy-encephalopathy-lactic acidosis-stroke syndrome Multiple lentigines syndrome (cardiocutaneous syndrome, ... renal pruritus) Psoriasis is a common, chronic, and recurrent inflammatory disease of the skin characterized by circumscribed, ...
https://en.wikipedia.org/wiki/List_of_skin_conditions
Ammonium chlorideAmmonium chloride
... in oral acid loading test to diagnose distal renal tubular acidosis, to maintain the urine at an acid pH in the treatment of ...
https://en.wikipedia.org/wiki/Ammonium_chloride
List of OMIM disorder codesList of OMIM disorder codes
SLC5A2 Renal tubular acidosis with deafness; 267300; ATP6B1 Renal tubular acidosis, distal, AD; 179800; SLC4A1 Renal tubular ... ACE Renal tubular dysgenesis; 267430; AGT Renal tubular dysgenesis; 267430; AGTR1 Renal tubular dysgenesis; 267430; REN Renal- ... SLC4A1 Renal tubular acidosis, distal, autosomal recessive; 602722; ATP6V0A4 Renal tubular acidosis, proximal, with ocular ... FLCN Renal cell carcinoma; 144700; DIRC2 Renal cell carcinoma; 144700; HNF1A Renal cell carcinoma; 144700; RNF139 Renal cell ...
https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes
Normal anion gap acidosisNormal anion gap acidosis
The most common cause of normal anion gap acidosis is diarrhea with a renal tubular acidosis being a distant second. The ... often from normal saline Acetazolamide and other carbonic anhydrase inhibitors Renal tubular acidosis Diarrhea: due to a loss ... hyperchloremic acidosis) or increased excretion of bicarbonate. High anion gap metabolic acidosis "Metabolic Acidosis: Acid- ... Normal anion gap acidosis is an acidosis that is not accompanied by an abnormally increased anion gap. ...
https://en.wikipedia.org/wiki/Normal_anion_gap_acidosis
Retrospective diagnosisRetrospective diagnosis
Squirrel Nutkin may have had Tourette syndrome and Tiny Tim could have had distal renal tubular acidosis (type I). Post-mortem ...
https://en.wikipedia.org/wiki/Retrospective_diagnosis
List of diseases (O)List of diseases (O)
... dermopathy white forelock Osteopetrosis autosomal dominant type 1 Osteopetrosis lethal Osteopetrosis renal tubular acidosis ... autosomal recessive Optic atrophy Optic disc drusen Optic nerve coloboma with renal disease Optic nerve disorder Optic nerve ... osseous syndrome Oculo dento digital dysplasia Oculo digital syndrome Oculo facio cardio dental syndrome Oculo skeletal renal ... Oikophobia Okamuto-Satomura syndrome Olfactophobia Oligodactyly Oligodactyly tetramelia postaxial Oligomeganephronic renal ...
https://en.wikipedia.org/wiki/List_of_diseases_(O)
Acute liver failureAcute liver failure
... independent of renal function. Lactic acidosis occurs predominantly in paracetamol (also known as acetaminophen) overdose. ... either due to original insult such as paracetamol resulting in acute tubular necrosis or from hyperdynamic circulation leading ... Hypophosphatemia is especially common in patients with acetaminophen-induced ALF and in those with intact renal function. ... resulting in tissue hypoxia and lactic acidosis. Pulmonary complications occur in up to 50% of patients. Severe lung injury and ...
https://en.wikipedia.org/wiki/Acute_liver_failure
AzacitidineAzacitidine
Renal tubular acidosis developed in five patients with chronic myelogenous leukemia (an unapproved use) treated with ... and patients with renal impairment may be at increased risk for renal toxicity. Azacitidine and its metabolites are primarily ...
https://en.wikipedia.org/wiki/Azacitidine
List of diseases (M)List of diseases (M)
... syndrome Maffucci syndrome Maghazaji syndrome Magnesium defect in renal tubular transport of Magnesium wasting renal Major ... Moebius Robin syndrome Myopathy ophthalmoplegia hypoacousia areflexia Myopathy tubular aggregates Myopathy with lactic acidosis ... Mitochondrial genetic disorders Mitochondrial myopathy lactic acidosis Mitochondrial myopathy-encephalopathy-lactic acidosis ... Mesomelic dysplasia skin dimples Mesomelic dysplasia Thai type Mesomelic syndrome Pfeiffer type Mesothelioma Metabolic acidosis ...
https://en.wikipedia.org/wiki/List_of_diseases_(M)
Hyperchloremic acidosisHyperchloremic acidosis
Diseases Database (DDB): 11673 NIH - Renal Tubular Acidosis (CS1 errors: missing periodical, Articles with short description, ... and loss of alkaline proximal small bowel secretions Chronic laxative abuse Renal causes Proximal renal tubular acidosis with ... 3 resorption Distal renal tubular acidosis with failure of H+ secretion Long-term use of a carbonic anhydrase inhibitor such as ... In general, the cause of a hyperchloremic metabolic acidosis is a loss of base, either a gastrointestinal loss or a renal loss ...
https://en.wikipedia.org/wiki/Hyperchloremic_acidosis
FurosemideFurosemide
Because of the large NaCl absorptive capacity of the loop of Henle, diuresis is not limited by development of acidosis, as it ... Furosemide is mainly excreted by tubular secretion in the kidney. In kidney impairment, clearance is reduced, increasing the ... Molecular weight (daltons) 330.7 % Bioavailability 47-70% Bioavailability with end-stage renal disease 43 - 46% % Protein ... concomitant renal disease and coadministration with other ototoxic medication. However, a recently reported longitudinal study ...
https://en.wikipedia.org/wiki/Furosemide
SepsisSepsis
... unexplained metabolic acidosis with base deficit > 5 mEq/L lactic acidosis: serum lactate 2 times the upper limit of normal ... Intermittent or continuous renal replacement therapy may be used if indicated. However, sodium bicarbonate is not recommended ... inadequate oxygenation results in tubular epithelial cell injury (of the cells lining the kidney tubules), and thus causes ... Signs of established sepsis include confusion, metabolic acidosis (which may be accompanied by a faster breathing rate that ...
https://en.wikipedia.org/wiki/Sepsis
Urine test stripUrine test strip
Other proteins include small amounts of serum and tubular microglobulins. Uromodulin produced by the renal tubular epithelial ... acidosis and in the end diabetic coma. The three ketone compounds appear in different proportions in the urine, although these ... The complex process of reabsorption is usually one of the first renal functions to be affected by disease. The specific gravity ... Routine urinalysis is recommended as a basic yet fundamental step in identifying renal damage and/or urinary tract disease at ...
https://en.wikipedia.org/wiki/Urine_test_strip
List of diseases (N)List of diseases (N)
Neurilemmomatosis Neuritis with brachial predilection Neuroacanthocytosis Neuroaxonal dystrophy renal tubular acidosis ...
https://en.wikipedia.org/wiki/List_of_diseases_(N)
Renal tubular acidosis with deafness: MedlinePlus GeneticsRenal tubular acidosis with deafness: MedlinePlus Genetics
... renal) problems and hearing loss. Explore symptoms, inheritance, genetics of this condition. ... Renal tubular acidosis with deafness is a disorder characterized by kidney ( ... Renal tubular acidosis with progressive nerve deafness. *Renal tubular acidosis, autosomal recessive, with progressive nerve ... medlineplus.gov/genetics/condition/renal-tubular-acidosis-with-deafness/ Renal tubular acidosis with deafness. ...
https://medlineplus.gov/genetics/condition/renal-tubular-acidosis-with-deafness
Browsing by Subject Acidosis, Renal TubularBrowsing by Subject "Acidosis, Renal Tubular"
Unusual association between renal tubular acidosis and Chilaiditi syndrome: a case report  ... Browsing by Subject "Acidosis, Renal Tubular". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. ...
https://apps.who.int/iris/browse?authority=Acidosis%2C+Renal+Tubular&type=mesh
Browsing by Subject Acidosis, Renal TubularBrowsing by Subject "Acidosis, Renal Tubular"
Unusual association between renal tubular acidosis and Chilaiditi syndrome: a case report  ... Browsing by Subject "Acidosis, Renal Tubular". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. ...
https://extranet.who.int/iris/restricted/browse?authority=Acidosis%2C+Renal+Tubular&type=mesh
Metabolic Acidosis Treatment & Management: Approach Considerations, Type 1 Renal Tubular Acidosis, Type 2 Renal Tubular AcidosisMetabolic Acidosis Treatment & Management: Approach Considerations, Type 1 Renal Tubular Acidosis, Type 2 Renal Tubular Acidosis
Metabolic acidosis should be considered a sign of an underlying disease process. ... Metabolic acidosis is a clinical disturbance characterized by an increase in plasma acidity. ... Type 1 Renal Tubular Acidosis. Administration of an alkali is the mainstay of treatment for type 1 renal tubular acidosis (RTA ... Type 2 Renal Tubular Acidosis. Correcting this form of acidosis with alkali is difficult because a substantial proportion of ...
https://www.medscape.com/answers/242975-154672/how-are-citrate-salts-used-in-the-treatment-for-metabolic-acidosis
Type 2 Renal Tubular AcidosisType 2 Renal Tubular Acidosis
... , Type II Renal Tubular Acidosis, Type II RTA, Proximal RTA, Proximal Renal Tubular Acidosis. ... Type 2 Renal Tubular Acidosis. Aka: Type 2 Renal Tubular Acidosis, Type II Renal Tubular Acidosis, Type II RTA, Proximal RTA, ... Type 2 Renal Tubular Acidosis. * Type 3 Renal Tubular Acidosis * Type 4 Renal Tubular Acidosis ... Renal Tubular Acidosis * Type 1 Renal Tubular Acidosis * ... Proximal Renal Tubular Acidosis *Epidemiology. *Most commonly ...
https://fpnotebook.com/legacy/Renal/AcidBase/TypRnlTblrAcds1.htm
Renal Tubular Acidosis (RTA)-Causes-Types-Diagnosis-Treatment-ComplicationsRenal Tubular Acidosis (RTA)-Causes-Types-Diagnosis-Treatment-Complications
Renal tubular acidosis causes include Addison s disease, drugs, mineralcorticoid deficiency. ... Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of the urine lower than ... Renal Tubular Acidosis is treated using alkaline agents like sodium bicarbonate and sodium citrate or potassium citrate. In ... Renal tubular acidosis is a condition where the kidneys are unable to maintain the acid base balance in the body due to defect ...
https://www.medindia.net/patients/patientinfo/renal-tubular-acidosis.htm
Quiz: Renal Tubular Acidosis RTA - Merck Manuals Consumer VersionQuiz: Renal Tubular Acidosis RTA - Merck Manuals Consumer Version
Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada)-dedicated to using leading-edge science to save and improve lives around the world. Learn more about the Merck Manuals and our commitment to Global Medical Knowledge.. ...
https://www.merckmanuals.com/en-pr/home/multimedia/quiz/renal-tubular-acidosis-rta
JCI - Inactive form of erythrocyte carbonic anhydrase B in patients with primary renal tubular acidosis.JCI - Inactive form of erythrocyte carbonic anhydrase B in patients with primary renal tubular acidosis.
Inactive form of erythrocyte carbonic anhydrase B in patients with primary renal tubular acidosis.. T Kondo, N Taniguchi, K ... found for an inactive form of carbonic anhydrase type B in the erythrocytes of two children with primary renal tubular acidosis ...
https://www.jci.org/articles/view/109167
Proximal renal tubular acidosis Information | Mount Sinai - New YorkProximal renal tubular acidosis Information | Mount Sinai - New York
... recovery and follow-up care for Proximal renal tubular acidosis. ... Learn about Proximal renal tubular acidosis, find a doctor, ... Proximal renal tubular acidosis. Renal tubular acidosis - proximal; Type II RTA; RTA - proximal; Renal tubular acidosis type II ... Renal tubular acidosis. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of ... Proximal renal tubular acidosis is a disease that occurs when the kidneys dont properly remove acids from the blood into the ...
https://www.mountsinai.org/health-library/diseases-conditions/proximal-renal-tubular-acidosis
WHO EMRO | Case reports: Unusual association between renal tubular acidosis and Chilaiditi syndrome: a case report | Volume 12,...
... the cause of ileus was severe hypokalaemia resulting from type-1 renal tubular acidosis. The causes of renal tubular acidosis ... Case reports: Unusual association between renal tubular acidosis and Chilaiditi syndrome: a case report ... To our knowledge, the development of Chilaiditi syndrome as a complication of severe hypokalaemia from renal tubular acidosis ... Unusual association between renal tubular acidosis and Chilaiditi syndrome: a case report ...
http://www.emro.who.int/ar/emhj-volume-12-2006/volume-12-issue-1-2/case-reports-unusual-association-between-renal-tubular-acidosis-and-chilaiditi-syndrome-a-case-report.html
KEGG DISEASE: Hyperkalemic distal renal tubular acidosis (RTA type 4)KEGG DISEASE: Hyperkalemic distal renal tubular acidosis (RTA type 4)
Renal tubular acidosis (RTA) is characterized by metabolic acidosis, a severe disturbance of extracellular pH homeostasis, due ... H00243 Hyperkalemic distal renal tubular acidosis (RTA type 4). Human diseases in ICD-11 classification [BR:br08403]. 16 ... New insights into the pathogenesis of renal tubular acidosis--from functional to molecular studies. ... Mutations in the genes encoding WNK1 and WNK4 kinases (WNK1 and WNK4), which regulate ion-transporters on renal tubules, were ...
https://www.kegg.jp/entry/H00243
A phenocopy of CAII deficiency: a novel genetic explanation for inherited infantile osteopetrosis with distal renal tubular...A phenocopy of CAII deficiency: a novel genetic explanation for inherited infantile osteopetrosis with distal renal tubular...
Osteopetrosis, renal tubular acidosis and basal ganglia calcification in three sisters. Am J Med1980;69:64-74. ... Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Nat Genet1999; ... Guibaud P, Larbre F, Freycon MT, Genoud J. Osteopetrosis and renal tubular acidosis. 2 cases of this association in a sibship. ... The association of osteopetrosis and renal tubular acidosis (RTA) was first described in 1972, and it is also referred to as ...
https://jmg.bmj.com/content/40/2/115
Hypernatremia and Hypophosphatemia in Distal Renal Tubular Acidosis: A Case Report of Acid-base and Electrolyte Misadventure |...Hypernatremia and Hypophosphatemia in Distal Renal Tubular Acidosis: A Case Report of Acid-base and Electrolyte Misadventure |...
... is easily recognized in patients with hypokalemia and normal anion gap acidosis. Other concurrent electrolyte abnormalities ... Prevalence of endemic distal renal tubular acidosis and renal stone in the Northeast of Thailand. Nephron. 1996;72(4):604-10. ... Distal renal tubular acidosis (RTA) is easily recognized in patients with hypokalemia and normal anion gap acidosis. Other ... Distal renal tubular acidosis (RTA) is a common referral to nephrology units worldwide. Reported prevalence varies between 2.8- ...
https://www.researchsquare.com/article/rs-577482/v1
Autosomal dominant osteopetrosis associated with renal tubular acidosis is due to a CLCN7 mutation -...
Autosomal dominant osteopetrosis associated with renal tubular acidosis is due to a CLCN7 mutation Share Share Share ... Autosomal dominant osteopetrosis associated with renal tubular acidosis is due to a CLCN7 mutation ...
https://www.ndm.ox.ac.uk/publications/640273
IMSEAR at SEARO: Distal renal tubular acidosis.
Distal renal tubular acidosis. Journal of the Association of Physicians of India. 1978 May; 26(5): 407-13. ...
https://imsear.searo.who.int/handle/123456789/95642
Renal Tubular Acidosis: A case Report | Journal of Postgraduate Medical Institute Renal Tubular Acidosis: A case Report | Journal of Postgraduate Medical Institute
Haider I, Alam I, Sherin A. Renal Tubular Acidosis: A case Report. J Postgrad Med Inst [Internet]. 2011 Oct. 6 [cited 2022 Dec ... Patient was diagnosed as Type I Renal tubular Acidosis on the basis of alkaline urine, nephrocalcinosis, hypokalemic ...
https://jpmi.org.pk/index.php/jpmi/article/view/953?articlesBySameAuthorPage=3
Distal Renal Tubular Acidosis Panel Test - PreventionGeneticsDistal Renal Tubular Acidosis Panel Test - PreventionGenetics
Hereditary forms of distal renal tubular acidosis (dRTA) result from impaired acid excretion at intercalated cells in the ... collecting tubules and are characterized by hyperchloremic metabolic acidosis without bicarbonaturia or diarrhea (Alper 2010; ... Renal Tubular Acidosis With Progressive Nerve Deafness. AR. 267300. Renal Tubular Acidosis, Distal, Autosomal Dominant. AD. ... Renal Tubular Acidosis, Distal, Autosomal Recessive. AR. 602722. Renal Tubular Acidosis, Distal, With Hemolytic Anemia. AR. ...
https://www.preventiongenetics.com/testInfo?val=Distal-Renal-Tubular-Acidosis-Panel
Renal Tubular Acidosis | 5-Minute Pediatric ConsultRenal Tubular Acidosis | 5-Minute Pediatric Consult
Renal Tubular Acidosis answers are found in the 5-Minute Pediatric Consult powered by Unbound Medicine. Available for iPhone, ... Renal tubular acidosis (RTA) is characterized by hyperchloremic metabolic acidosis in the setting of normal or near-normal ... Renal tubular acidosis (RTA) is characterized by hyperchloremic metabolic acidosis in the setting of normal or near-normal ... Acidosis. Accessed November 28, 2022.. Renal Tubular Acidosis. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult (8th ...
https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617202/all/Renal_Tubular_Acidosis?q=oxaliplatin
Instructions for Classification of Underlying and Multiple Causes of Death - Appendix - 2020Instructions for Classification of Underlying and Multiple Causes of Death - Appendix - 2020
RTA renal tubular acidosis. RUL right upper lobe. RUQ right upper quadrant ... CRF cardiorespiratory failure; chronic renal failure. CRST calcinosis cutis, Raynaud phenomenon, sclerodactyly, and ...
https://www.cdc.gov/nchs/nvss/manuals/2020/2a-appendix-2020.htm
Metabolic Acidosis Treatment & Management: Approach Considerations, Type 1 Renal Tubular Acidosis, Type 2 Renal Tubular Acidosis
Metabolic acidosis should be considered a sign of an underlying disease process. ... Metabolic acidosis is a clinical disturbance characterized by an increase in plasma acidity. ... Type 1 Renal Tubular Acidosis. Administration of an alkali is the mainstay of treatment for type 1 renal tubular acidosis (RTA ... Type 2 Renal Tubular Acidosis. Correcting this form of acidosis with alkali is difficult because a substantial proportion of ...
https://www.staging.medscape.com/answers/242975-154665/what-agent-is-most-commonly-used-to-correct-metabolic-acidosis-and-how-is-administered
A study of recurrent stone formers with special reference to renal tubular acidosis<...
N2 - Forty-five patients with recurrent renal stone were examined for distal renal tubular acidosis (dRTA) defects by acid ... AB - Forty-five patients with recurrent renal stone were examined for distal renal tubular acidosis (dRTA) defects by acid ... Forty-five patients with recurrent renal stone were examined for distal renal tubular acidosis (dRTA) defects by acid challenge ... abstract = "Forty-five patients with recurrent renal stone were examined for distal renal tubular acidosis (dRTA) defects by ...
https://augusta.pure.elsevier.com/en/publications/a-study-of-recurrent-stone-formers-with-special-reference-to-rena
Hyperchloremic Acidosis Differential DiagnosesHyperchloremic Acidosis Differential Diagnoses
... in particular the renal tubular acidoses (RTAs). It also addresses approaches to the diagnosis and management of these ... This article covers the pathophysiology and causes of hyperchloremic metabolic acidoses, ... Prevalence of distal renal tubular acidosis in patients with calcium phosphate stones. World J Urol. 2020 Mar. 38 (3):789-94. [ ... The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis. Kidney Int. 2017 May. 91 (5 ...
https://emedicine.medscape.com/article/240809-differential
Hypokalemic Periodic Paralysis Precipitated by Thyrotoxicosis and Renal Tubular Acidosis<...
Hypokalemic Periodic Paralysis Precipitated by Thyrotoxicosis and Renal Tubular Acidosis. In: Case Reports in Endocrinology. ... Hypokalemic Periodic Paralysis Precipitated by Thyrotoxicosis and Renal Tubular Acidosis. Case Reports in Endocrinology. 2021; ... Hypokalemic Periodic Paralysis Precipitated by Thyrotoxicosis and Renal Tubular Acidosis. Ian Jackson, Yazan Addasi, Moeed ... Hypokalemic Periodic Paralysis Precipitated by Thyrotoxicosis and Renal Tubular Acidosis. / Jackson, Ian; Addasi, Yazan; Ahmed ...
https://creighton.pure.elsevier.com/en/publications/hypokalemic-periodic-paralysis-precipitated-by-thyrotoxicosis-and
Renal tubular acidosis in children Mittal K, Mittal A - J Pediatr Crit CareRenal tubular acidosis in children Mittal K, Mittal A - J Pediatr Crit Care
Renal tubular acidosis in children. Kundan Mittal1, Anindya Mittal2. 1 Department of Pediatrics, Pt. B D Sharma, PGIMS, Rohtak ... Renal tubular acidosis (RTA) is a rare disease in children and the incidence is low, i.e., 1:106 in general population. ... Mittal K, Mittal A. Renal tubular acidosis in children. J Pediatr Crit Care [serial online] 2022 [cited 2022 Dec 8];9:72. ... Mittal K, Mittal A. Renal tubular acidosis in children. J Pediatr Crit Care 2022;9:72. ...
https://jpcc.org.in/article.asp?issn=2349-6592
Nephrolithiasis In Renal Tubular Acidosis | Best Nephrologist In Delhi | Dr Rajesh Goel | Kidney Care Centre
Renal tubular acidosis is a rare kind of kidney disorder that occurs due to the inability of the kidneys to excrete acids from ... Renal tubular acidosis is of four types- type 1 or distal renal tubular acidosis, type 2 or proximal renal tubular acidosis, ... type 3 or mixed renal tubular acidosis, and type 4 or hyperkalemic renal tubular acidosis. Type 1 or distal renal tubular ... Renal tubular acidosis is a rare kind of kidney disorder that occurs due to the inability of the kidneys to excrete acids from ...
https://www.kidneycarecentre.in/urology-disoders/nephrolithiasis-and-nephrocalcinosis/nephrolithiasis-in-renal-tubular-acidosis/
Low Salt Diet in Idiopathic Hypercalciuria - Full Text View - ClinicalTrials.govLow Salt Diet in Idiopathic Hypercalciuria - Full Text View - ClinicalTrials.gov
... renal tubular acidosis, sarcoidosis, sponge kidney, hyperthyroidism, use of hypercalciuric drugs such as Vitamin D, ...
https://clinicaltrials.gov/ct2/show/NCT01005082
Toluene | Medical Management Guidelines | Toxic Substance Portal | ATSDR
Renal tubular acidosis, glomerulonephritis, myoglobinuria, and renal failure have been observed (Poisondex, 2014). ... In solvent abusers, electrolyte and acid-base disturbances have resulted in renal tubular acidosis, deficiency of potassium, ... Disorders of the muscles, cardiovascular effects, renal tubular damage, and sudden death have occurred in chronic abusers of ... Renal. Blood and protein in the urine can occur after massive inhalation. These effects are usually reversible if exposure is ...
https://wwwn.cdc.gov/TSP/MMG/MMGDetails.aspx?mmgid=157&toxid=29
Quintanilla AP[au] - Search Results - PubMedQuintanilla AP[au] - Search Results - PubMed
Renal tubular acidosis: mechanisms and management. Quintanilla AP. Quintanilla AP. Postgrad Med. 1980 Apr;67(4):60-73. doi: ... Pathophysiology of renal concentrating defects. Quintanilla AP. Quintanilla AP. Ann Clin Lab Sci. 1981 Jul-Aug;11(4):300-7. Ann ... Renal hemodynamics and water excretion in Addisons disease. Quintanilla AP, Delgado-Butron C, Zeballos J. Quintanilla AP, et ...
https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=Quintanilla+AP%5Bau%5D&dispmax=50
Novel Maladies: Darth Vader, Tintin, and Squirrel Nutkin Diagnosed - Mother JonesNovel Maladies: Darth Vader, Tintin, and Squirrel Nutkin Diagnosed - Mother Jones
Diagnosis: Distal renal tubular acidosis (Type I). Discussion: D.W. Lewis writes in the American Journal of Diseases of ...
https://www.motherjones.com/media/2010/10/tintin-darth-vader-disorder/
MetabolicExcretionEvaluation of Renal TubularBicarbonateCarbonicDRTAOsteopetrosisAcidose Tubular RenalHereditaryAnion gapDiabeticFanconiKidneysSevereAutosomalPotassiumLacticAcidificationNephrogenicPathophysiologyImpairmentAcidTubulesSymptoms2016Proximal tubular dysfunctionHyperthyroidism2020ClinicalDysfunction-cholestasisHyperkalemicDiseaseUrineHyperchloremic AcidosisDiagnosisDiarrheaSodium2022UrinaryPrevalenceNephrolithiasisNecrosisHypokalemiaTypeCalcium phosphate2017TubulointerstitialMutationsCalculiChilaiditiPhysiology
Metabolic42
  • This chemical imbalance, called metabolic acidosis, can result in a range of signs and symptoms that vary in severity. (medlineplus.gov)
  • Treatment of acute metabolic acidosis with alkali therapy is usually indicated to raise and maintain the plasma pH to greater than 7.20. (medscape.com)
  • For example, in a patient with metabolic acidosis with a serum HCO 3 - level of 9 mEq/L and a maximally compensated PCO 2 of 20 mm Hg, a drop in the serum HCO 3 - level to 7 mEq/L results in a change in pH from 7.28 to 7.16. (medscape.com)
  • A second situation in which HCO 3 - correction should be considered is in well-compensated metabolic acidosis with impending respiratory failure. (medscape.com)
  • As metabolic acidosis continues in some patients, the increased ventilatory drive to lower the PaCO 2 may not be sustainable because of respiratory muscle fatigue. (medscape.com)
  • For example, in a patient with metabolic acidosis with a serum HCO 3 - level of 15 and a compensated PaCO 2 of 27 mm Hg, a rise in PaCO 2 to 37 mm Hg results in a change in pH from 7.33 to 7.20. (medscape.com)
  • Sodium bicarbonate (NaHCO 3 ) is the agent most commonly used to correct metabolic acidosis. (medscape.com)
  • This is especially true in certain forms of metabolic acidosis. (medscape.com)
  • His past history was significant for severe duodenitis, chronic diarrhoea, hypokalaemia and metabolic acidosis. (who.int)
  • The patient was given intravenous fluids and potassium to correct his metabolic acidosis and hypokalaemia. (who.int)
  • The patient continued to have metabolic acidosis and severe hypokalaemia post-surgery for which a nephrology consultation was obtained and the patient was diagnosed as a case of renal tubular acidosis ( Table 1 ). (who.int)
  • Renal tubular acidosis (RTA) is characterized by metabolic acidosis, a severe disturbance of extracellular pH homeostasis, due to renal impaired acid excretion. (kegg.jp)
  • Primary pseudohypoaldosteronism type 1 (PHA1) is characterized by salt-wasting, hyperkalemia, and metabolic acidosis in the presence of markedly elevated plasma renin activity and aldosterone concentration. (kegg.jp)
  • She required mechanical ventilation due to severe metabolic acidosis and hypokalemia. (researchsquare.com)
  • Blood investigations revealed severe hypokalemia with normal anion gap metabolic acidosis. (researchsquare.com)
  • Renal tubular acidosis (RTA) is characterized by hyperchloremic metabolic acidosis in the setting of normal or near-normal glomerular filtration rate (GFR). (unboundmedicine.com)
  • In distal RTA, mutations in the basolateral anion exchanger or the H + -ATPase prevent bicarbonate transport into the bloodstream and hydrogen ion secretion into the lumen, respectively, resulting in impaired net acid secretion and non-anion gap metabolic acidosis. (unboundmedicine.com)
  • Distal RTA type IV is associated with either low aldosterone levels or aldosterone resistance and presents with hyperkalemic non-anion gap metabolic acidosis. (unboundmedicine.com)
  • Kraut JA, Kurtz I. Treatment of acute non-anion gap metabolic acidosis. (medscape.com)
  • Labs showed hypokalemia, hyperthyroidism, and nonanion gap metabolic acidosis with a positive urine anion gap. (elsevier.com)
  • disruption of the normal acid-base balance, increased acid levels in the blood and a condition called metabolic acidosis. (kidneycarecentre.in)
  • Metabolic acidosis is a condition in which there is too much acid in the body fluids. (medlineplus.gov)
  • Metabolic acidosis develops when too much acid is produced in the body. (medlineplus.gov)
  • Most symptoms are caused by the underlying disease or condition that is causing the metabolic acidosis. (medlineplus.gov)
  • Metabolic acidosis itself most often causes rapid breathing. (medlineplus.gov)
  • Severe metabolic acidosis can lead to shock or death. (medlineplus.gov)
  • In some situations, metabolic acidosis can be a mild, ongoing (chronic) condition. (medlineplus.gov)
  • Seek medical help if you have symptoms of any disease that can cause metabolic acidosis. (medlineplus.gov)
  • Health benefits of baking soda include reduced risk and prevention of diarrhea , metabolic acidosis, acidity , peptic ulcer, and drug intoxication. (organicfacts.net)
  • Sodium bicarbonate is beneficial in minimizing the risk of metabolic acidosis in various health disorders. (organicfacts.net)
  • Less often, the reasons for investigation are laboratory findings such as proteinuria, hypokalemia , hypophosphatemia, and hyperchloremic metabolic acidosis. (medscape.com)
  • Monitor for lithium toxicity and metabolic acidosis. (nih.gov)
  • Metabolic acidosis, diabetic ketoacidosis. (clinicaladvisor.com)
  • This article covers the pathophysiology and causes of hyperchloremic metabolic acidoses , in particular the renal tubular acidoses (RTAs). (medscape.com)
  • A low plasma bicarbonate (HCO 3 - ) concentration represents, by definition, metabolic acidosis, which may be primary or secondary to a respiratory alkalosis. (medscape.com)
  • Loss of bicarbonate stores through diarrhea or renal tubular wasting leads to a metabolic acidosis state characterized by increased plasma chloride concentration and decreased plasma bicarbonate concentration. (medscape.com)
  • Primary metabolic acidoses that occur as a result of a marked increase in endogenous acid production (eg, lactic or keto acids) or progressive accumulation of endogenous acids when excretion is impaired by renal insufficiency are characterized by decreased plasma bicarbonate concentration and increased anion gap without hyperchloremia. (medscape.com)
  • The initial differentiation of metabolic acidosis should involve a determination of the anion gap (AG). (medscape.com)
  • For this reason, it is also known as hyperchloremic metabolic acidosis. (medscape.com)
  • Go to Metabolic Acidosis , Pediatric Metabolic Acidosis , and Emergent Management of Metabolic Acidosis for complete information on these topics. (medscape.com)
  • A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. (bvsalud.org)
  • The 'cases' met the diagnostic criteria for PRTD, determined by the presence of two or more of the following abnormalities: non-diabetic glycosuria, metabolic acidosis, increased uric acid and phosphorus excretion, decreased tubular phosphorus reabsorption and β2-microglobulinuria. (lww.com)
Excretion4
  • Potassium balance and serum potassium level are maintained until very late in chronic kidney disease (CKD), mainly because of an increase in renal and colonic excretion. (koreamed.org)
  • Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA , hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS , and RICKETS . (bvsalud.org)
  • The genetic defect is in the anion exchange protein gene SLC4A1 resulting in impaired excretion of hydrogen ions or renal acids in the distal renal tubules. (bvsalud.org)
  • The renal function was evaluated through daily urinalysis, fractioned excretion of sodium and potassium, serum concentration of creatinine and blood urea nitrogen (BUN) and urinary activity of gamma-glutamyltransferase (GGT). (unesp.br)
Evaluation of Renal Tubular2
  • Evaluation of Renal Tubular Acidosis. (medindia.net)
  • Yaxley J, Pirrone C. Review of the Diagnostic Evaluation of Renal Tubular Acidosis. (medscape.com)
Bicarbonate10
  • In lactic acidosis and diabetic ketoacidosis, the organic anion can regenerate bicarbonate when the underlying disorder is corrected, and caution must be exercised in trying to correct the acidosis with bicarbonate therapy, unless the pH is less than 7.0-7.1. (medscape.com)
  • Renal tubular acidosis is a condition where the kidneys are unable to maintain the acid base balance in the body due to defect in secretion of acid, reabsorption of bicarbonate or both. (medindia.net)
  • Proximal renal tubular acidosis (type II RTA) occurs when bicarbonate is not properly reabsorbed by the kidney's filtering system. (mountsinai.org)
  • Delayed correction of acidosis with sodium bicarbonate led to severe hypernatremia (180mmol/L) and slow recovery of serum potassium level. (researchsquare.com)
  • Hyperchloremic acidosis is caused by the loss of too much sodium bicarbonate from the body, which can happen with severe diarrhea. (medlineplus.gov)
  • Acidosis is mainly caused by a defect in the reabsorption of bicarbonate in the proximal tubule. (medscape.com)
  • As in all other forms of proximal renal tubular acidosis, the threshold for bicarbonate is low, but distal acidification is normal. (medscape.com)
  • A normal AG acidosis is characterized by a lowered bicarbonate concentration, which is counterbalanced by an equivalent increase in plasma chloride concentration. (medscape.com)
  • The genetic defect is in the sodium bicarbonate cotransporter gene SLC4A4 resulting in impaired reabsorption of bicarbonate ions in the proximal renal tubules and bicarbonate-wasting. (bvsalud.org)
  • Renal tubular dysfunction ranges from isolated renal tubular acidosis to full-blown Fanconi syndrome (polyuria, aminoaciduria, glycosuria, phosphaturia, and bicarbonate loss). (altmeyers.org)
Carbonic2
  • Inactive form of erythrocyte carbonic anhydrase B in patients with primary renal tubular acidosis. (jci.org)
  • Evidence was found for an inactive form of carbonic anhydrase type B in the erythrocytes of two children with primary renal tubular acidosis. (jci.org)
DRTA3
  • Forty-five patients with recurrent renal stone were examined for distal renal tubular acidosis (dRTA) defects by acid challenge test (150 mg ammonium chloride/kg body weight). (elsevier.com)
  • Sibnayal™ is the first and only label-approved drug for the treatment of Distal renal tubular acidosis (dRTA) in adults, adolescents, and children aged one year and older. (pharmiweb.com)
  • We are proud to be partnering with Advicenne for the delivery of Sibnayal™ to patients and improve the lives of those suffering from Distal Renal Tubular Acidosis (dRTA). (pharmiweb.com)
Osteopetrosis3
  • The rare bone thickening disease osteopetrosis occurs in various forms, one of which is accompanied by renal tubular acidosis (RTA), and is known as Guibaud-Vainsel syndrome or marble brain disease. (bmj.com)
  • The association of osteopetrosis and renal tubular acidosis (RTA) was first described in 1972, and it is also referred to as Guibaud-Vainsel syndrome or marble brain disease (MIM 259730, http://www.ncbi.nlm.nih.gov/Omim/ ). (bmj.com)
  • The presence of primary neurodegeneration, mental retardation, skin and immune system involvement, or renal tubular acidosis may point to rarer osteopetrosis variants, whereas onset of primarily skeletal manifestations such as fractures and osteomyelitis in late childhood or adolescence is typical of ADO. (biomedcentral.com)
Acidose Tubular Renal1
  • Concluiu-se que a anfotericina B provoca lesões nos túbulos proximal e distal, induzindo acidose tubular renal do tipo I e Diabetes insipidus nefrogênico em cães. (unesp.br)
Hereditary3
  • The causes of renal tubular acidosis include hereditary disorders, autoimmune diseases and certain drugs such as amphotericin B, lithium and analgesics. (who.int)
  • Mass RE, Smith WR, Walsh JR. The association of hereditary fructose intolerance and renal tubular acidosis. (medscape.com)
  • Hereditary occurrence of cystic disease of the renal medulla. (dattaweb.com)
Anion gap2
  • Distal renal tubular acidosis (RTA) is easily recognized in patients with hypokalemia and normal anion gap acidosis. (researchsquare.com)
  • Patient was diagnosed as Type I Renal tubular Acidosis on the basis of alkaline urine, nephrocalcinosis, hypokalemic hyperchloremic metabolicacidosis with normal serum anion gap and positive ammonium chloride challenge test. (org.pk)
Diabetic2
  • A 56-year-old man suffered from severe diabetic ketoacidosis which was complicated by acute renal failure and rhabdomyolysis. (nel.edu)
  • Diabetic acidosis (also called diabetic ketoacidosis and DKA) develops when substances called ketone bodies (which are acidic) build up during uncontrolled diabetes (usually type 1 diabetes). (medlineplus.gov)
Fanconi2
  • Proximal RTA is often associated with Fanconi syndrome in which there is general proximal tubular dysfunction leading to bicarbonaturia, glucosuria, phosphaturia, and tubular proteinuria. (unboundmedicine.com)
  • A female patient of Greek origin presented on the 14th day of life with renal tubular acidosis, Fanconi syndrome, nephrogenic diabetes insipidus, and cholestasis with normal gamma-glutamyl transpeptidase, without arthrogryposis and dysmorphic features. (hindawi.com)
Kidneys4
  • Proximal renal tubular acidosis is a disease that occurs when the kidneys don't properly remove acids from the blood into the urine. (mountsinai.org)
  • Renal tubular acidosis is a rare kind of kidney disorder that occurs due to the inability of the kidneys to excrete acids from the blood into the urine normally. (kidneycarecentre.in)
  • Kidney stones (also called renal calculi, nephrolithiasis or urolithiasis) are hard deposits made of minerals and salts that form inside your kidneys. (mayoclinic.org)
  • Chloride levels above 106 could point to kidney problems, such as renal tubular acidosis (when your kidneys aren't removing enough acids from your blood and into your urine). (webmd.com)
Severe3
  • In this case, the cause of ileus was severe hypokalaemia resulting from type-1 renal tubular acidosis. (who.int)
  • To our knowledge, the development of Chilaiditi syndrome as a complication of severe hypokalaemia from renal tubular acidosis has not been reported in the English language literature. (who.int)
  • Severe Rhabdomyolysis as Presentation of Distal Renal Tubular Acidosis. (ttuhsc.edu)
Autosomal1
  • Arthrogryposis renal dysfunction cholestasis syndrome is a rare, apparently globally occurring, autosomal recessive inherited, multisystemic disease with the obligatory symptoms of neurogenic arthrogryposis multiplex congenita, renal tubulopathy and neonatal cholestasis with low activity of gamma glutamyl transferase in serum. (altmeyers.org)
Potassium7
  • Rarely, people with renal tubular acidosis with deafness have episodes of hypokalemic paralysis, a condition that causes extreme muscle weakness associated with low levels of potassium in the blood (hypokalemia). (medlineplus.gov)
  • Potassium citrate can be useful when the acidosis is accompanied by hypokalemia but should be used cautiously in the presence of kidnery impairment and must be avoided in the presence of hyperkalemia. (medscape.com)
  • It is important to recognize distal RTA early as treatment involves prompt correction of acidosis, without which results in futile replacement of potassium. (researchsquare.com)
  • Acidosis contributes to this outcome by increasing the filtered load of potassium. (medscape.com)
  • Potassium citrate can be used to help treat a kidney stone illness known as renal tubular acidosis. (antiaging-systems.com)
  • Renal function evaluation, preferably by serum creatinine, BUN and potassium dosage is recommended before each drug application. (unesp.br)
  • Long-term treatment with potassium citrate and renal stones in medullary sponge kidney. (dattaweb.com)
Lactic4
Acidification1
  • 3) Higashihara E, Nutahara K, Tago K, Ueno A, Niijima T. Medullary sponge kidney and renal acidification defect. (dattaweb.com)
Nephrogenic1
  • It was concluded that amphotericin b provokes lesions in both proximal and distal tubules, inducing type I renal tubular acidosis and nephrogenic Diabetes insipidus in dogs. (unesp.br)
Pathophysiology2
  • Molecular pathophysiology of renal tubular acidosis. (kegg.jp)
  • Pathophysiology of renal concentrating defects. (nih.gov)
Impairment2
  • Hypophosphatemia is secondary to the impairment in proximal tubular reabsorption. (medscape.com)
  • May add a thiazolidinedione or use in renal impairment: see full labeling. (clinicaladvisor.com)
Acid6
  • As a result, too much acid remains in the blood (called acidosis ). (mountsinai.org)
  • The basolateral anion exchanger 1 (AE1) encoded by the SLC4A1 gene (19 coding exons) has the greatest expression abundance in erythrocytes and type A acid-secreting intercalated cells of the renal collecting duct. (preventiongenetics.com)
  • Davenport A. Potential adverse effects of replacing high volume hemofiltration exchanges on electrolyte balance and acid-base status using the current commercially available replacement solutions in patients with acute renal failure. (medscape.com)
  • Advances in the field of genetic and molecular biology have established modification in understanding the basic renal physiology and acid-base disturbances. (org.in)
  • This book contains 11 chapters starting from understanding the systemic and renal regulation of acid-base metabolism to classification of RTA and differences between different RTA types. (org.in)
  • Examples include people with renal tubular acidosis and people with problems metabolizing a variety of chemicals including cystine (an amino acid), oxalate, (a salt of an organic acid), and uric acid (as in gout ). (emedicinehealth.com)
Tubules2
  • Mutations in the genes encoding WNK1 and WNK4 kinases (WNK1 and WNK4), which regulate ion-transporters on renal tubules, were identified in patients with PHA2. (kegg.jp)
  • This extra calcium may be deposited in the renal tubules or in the pelvis to form renal calculus. (doctorbhatia.com)
Symptoms3
  • Mutations in the ATP6V1B1 or ATP6V0A4 gene impair the function of the V-ATPase complex and reduce the body's capability to control the pH of the blood and the fluid in the inner ear, resulting in the signs and symptoms of renal tubular acidosis with deafness. (medlineplus.gov)
  • Type 1 or distal renal tubular acidosis leads to nephrolithiasis or the formation of kidney stones, apart from causing other symptoms. (kidneycarecentre.in)
  • The result can be growth retardation, kidney stones, bone disease and progressive renal failure-symptoms that seem to match some of Tiny Tim's. (nbcnews.com)
20161
  • Ilhan O et al (2016) Arthrogryposis-renal tubular dysfunction-cholestasis syndrome: a cause of neonatal cholestasis. (altmeyers.org)
Proximal tubular dysfunction2
  • Its presence in distal RTA without other evidence of proximal tubular dysfunction, to the best of our knowledge, has not been reported. (researchsquare.com)
  • Proximal tubular dysfunction related to tenofovir in people. (lww.com)
Hyperthyroidism3
  • We present a case of acquired hypokalemic periodic paralysis associated with hyperthyroidism and renal tubular acidosis. (elsevier.com)
  • Systemic lupus erythematosus and renal tubular acidosis associated with hyperthyroidism. (nel.edu)
  • Deng D, Sun L, Xia T, Xu M, Wang Y, Zhang Q. Systemic lupus erythematosus and renal tubular acidosis associated with hyperthyroidism. (nel.edu)
20201
Clinical7
  • Renal tubular acidosis: the clinical entity. (kegg.jp)
  • The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis. (medscape.com)
  • Clinical features, genetic background, and outcome in infants with urinary tract infection and type IV renal tubular acidosis. (medscape.com)
  • Reversing the intracardiac acidosis may help to discriminate between a clinical trial, should be consulted. (cardiacgenetic.com)
  • The purpose of this case-control study was to verify the association between single nucleotide polymorphisms (SNPs) in genes encoding drug transporters related to tenofovir disoproxil fumarate (TDF) and proximal renal tubular dysfunction (PRTD), and the association between PRTD and clinical characteristics. (lww.com)
  • Huang DG et al (2017) Clinical features and VPS33B mutations in a family affected by arthrogryposis, renal dysfunction, and cholestasis syndrome. (altmeyers.org)
  • En: Oxford Textbook of Clinical Nephrology. (dattaweb.com)
Dysfunction-cholestasis2
  • Chai M et al (2018) Identification of genes and signaling pathways associated with arthrogryposis-renal dysfunction-cholestasis syndrome using weighted correlation network analysis. (altmeyers.org)
  • Moon AT et al (2017) A Novel VPS33B Mutation in a Patient with Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome. (altmeyers.org)
Hyperkalemic1
  • Renal tubular acidosis is of four types- type 1 or distal renal tubular acidosis, type 2 or proximal renal tubular acidosis, type 3 or mixed renal tubular acidosis, and type 4 or hyperkalemic renal tubular acidosis. (kidneycarecentre.in)
Disease5
  • Renal tubular acidosis (RTA) is a rare disease in children and the incidence is low, i.e., 1:10 6 in general population. (org.in)
  • Opportunistic infection in immunosuppressed renal transplant patients with recurrent disease. (ttuhsc.edu)
  • Kidney disease (uremia, distal renal tubular acidosis or proximal renal tubular acidosis). (medlineplus.gov)
  • In advanced cases of renal disease, the distal acidifying mechanism is also impaired. (medscape.com)
  • One theory floating around the Web is that Tiny Tim suffered from renal tubular acidosis (RTA), a kidney disease that makes blood too acidic. (nbcnews.com)
Urine1
  • Each nephron consists of two parts: a renal corpuscle (also known as a glomerulus) that filters the blood, and a renal tubule that reabsorbs substances that are needed and eliminates unneeded substances in urine. (medlineplus.gov)
Hyperchloremic Acidosis3
  • Sharma S, Hashmi MF, Aggarwal S. Hyperchloremic Acidosis. (medscape.com)
  • Toyonaga Y, Kikura M. Hyperchloremic acidosis is associated with acute kidney injury after abdominal surgery. (medscape.com)
  • If the cause of a patient's acidosis is not apparent from the history and physical examination findings, the next step is to determine whether hyperchloremic acidosis is present. (medscape.com)
Diagnosis2
  • Molecular Diagnosis and Identification of Genetic Variants Underlying Distal Renal Tubular Acidosis in Pakistani Patients Using Whole Exome Sequencing. (medindia.net)
  • renal involvement have a diagnosis of acute arthritis. (cardiacgenetic.com)
Diarrhea1
  • It has been determined that woods effectively cool air and structures around them the actual situation of diarrhea and renal tubular acidosis. (journalnewsnet.com)
Sodium1
  • In conclusion, correction of acidosis in distal RTA should be prioritised to avoid prolonged hypokalemia and significant increase in serum sodium. (researchsquare.com)
20221
  • Retrieved on Nov 30, 2022 from https://www.medindia.net/patients/patientinfo/renal-tubular-acidosis.htm. (medindia.net)
Urinary2
  • Untreated distal or type 1 renal tubular acidosis often results in hypocitraturia, nephrolithiasis, increased urinary pH, hypercalciuria, and bone abnormalities. (kidneycarecentre.in)
  • Renal stone or calculus or lithiasis is one of the most common diseases of the urinary tract. (doctorbhatia.com)
Prevalence1
  • Prevalence of distal renal tubular acidosis in patients with calcium phosphate stones. (medscape.com)
Nephrolithiasis1
  • There are several factors that contribute to nephrolithiasis or stone formation in distal renal tubular acidosis. (kidneycarecentre.in)
Necrosis2
  • The underlying cause of proximal renal tubular necrosis should be corrected if it can be found. (mountsinai.org)
  • High parasitemia levels can cause massive hemoglobinuria, acute renal tubular necrosis, and renal failure. (cdc.gov)
Hypokalemia1
  • After renal transplantation, we are more likely to encounter hyperkalemia rather than hypokalemia. (koreamed.org)
Type4
  • Type I is also called distal renal tubular acidosis . (mountsinai.org)
  • This syndrome is called pseudohypoaldosteronism type 2 (PHA2), or Gordon's syndrome, which results in a renal aldosterone resistance. (kegg.jp)
  • A case of fulminant type 1 diabetes associated with acute renal failure. (nel.edu)
  • Deng D, Xia L, Chen M, Xu M, Wang Y, Wang C. A case of fulminant type 1 diabetes associated with acute renal failure. (nel.edu)
Calcium phosphate1
  • The histopathological features of kidney stones formed due to distal renal tubular acidosis show calcium phosphate deposition on the Bellini ducts and inner medullary layer, which leads to fibrosis. (kidneycarecentre.in)
20171
  • Material y métodos: Se realizó un estudio retrospectivo, observacional de corte, entre los años 2000 y 2017 en donde se estudiaron 37 pacientes con riñón en esponja y litiasis renal (26 mujeres y 11 hombres) de 37.3 ± 13.2 años. (dattaweb.com)
Tubulointerstitial2
  • It is also often seen in a number of tubulointerstitial renal diseases. (kegg.jp)
  • Tubulointerstitial nephritis and renal tubular acidosis of different types are rare but important complications of primary biliary cirrhosis. (thieme-connect.de)
Mutations1
  • Renal tubular acidosis with deafness is caused by mutations in the ATP6V1B1 or ATP6V0A4 gene. (medlineplus.gov)
Calculi2
  • Chronic hypercalcemia may result in the formation of renal calculi. (clevelandclinicmeded.com)
  • Renal calculi can vary in size from as small as grains of sand to as large as a golf ball. (doctorbhatia.com)
Chilaiditi1
  • We report the first case of Chilaiditi syndrome caused by adynamic ileus result-ing from hypokalaemia induced by renal tubular acidosis. (who.int)
Physiology1