Acid Ceramidase: A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of ceramide to sphingosine and free fatty acid. Inherited deficiency of acid ceramidase activity results in FARBER LIPOGRANULOMATOSIS.Galactosylgalactosylglucosylceramidase: An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galactose.Neutral Ceramidase: A ceramidase subtype that is active at neutral pH. It is found at high levels within the SMALL INTESTINE and in the BRAIN.Ceramidases: Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.Alkaline Ceramidase: A ceramidase subtype that is active at alkaline pH. It is found at high levels within the SMALL INTESTINE.Farber Lipogranulomatosis: A sphingolipidosis subtype that is characterized by the histological appearance of granulomatous deposits in tissues. It results from the accumulation of CERAMIDES in various tissues due to an inherited deficiency of ACID CERAMIDASE.Ceramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.AmidohydrolasesSphingosine: An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)Sphingolipids: A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)Myristates: Salts and esters of the 14-carbon saturated monocarboxylic acid--myristic acid.Sphingomyelin Phosphodiesterase: An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.Sphingolipid Activator Proteins: A family of glycoprotein cofactors that are required for the efficient catabolization of SPHINGOLIPIDS by specific acid hydrolases such as GLUCOSYLCERAMIDASE; GALACTOCEREBROSIDASE; BETA-N-ACETYLHEXOSAMINIDASE; and CEREBROSIDE-SULFATASE.Monoglycerides: GLYCEROL esterified with a single acyl (FATTY ACIDS) chain.Lysosomal Storage Diseases: Inborn errors of metabolism characterized by defects in specific lysosomal hydrolases and resulting in intracellular accumulation of unmetabolized substrates.Lysophospholipids: Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.Dolichol Phosphates: Phosphoric acid esters of dolichol.Saposins: A group of four homologous sphingolipid activator proteins that are formed from proteolytic cleavage of a common protein precursor molecule referred to as prosaposin.
(1/51) Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide.

A fluorescent analogue of ceramide, C12-NBD-ceramide, was found to be hydrolyzed much faster than 14C-labeled ceramide by alkaline ceramidase from Pseudomonas aeruginosa and neutral ceramidase from mouse liver, while this substrate was relatively resistant to acid ceramidase from plasma of the horseshoe crab. The radioactive substrate was used more preferentially by the acid ceramidase. It should be noted that C6-NBD-ceramide, which is usually used for ceramidase assays, was hardly hydrolyzed by any of the enzymes examined, compared to C12-NBD-ceramide. For the alkaline and neutral enzymes, the Vmax and k (Vmax/Km) with C12-NBD-ceramide were much higher than those with 14C-ceramide. In contrast, for the acid enzyme these parameters with C12-NBD-ceramide were less than half those with the radioisotope-labeled substrate. It is noteworthy that the labeling of ceramide with NBD did not itself reduce the Km of the alkaline enzyme, but did that of the neutral enzyme. It was also found that C12-NBD-ceramide was preferentially hydrolyzed by the alkaline and neutral enzymes, but not the acid one, in several mammalian cell lines. This study clearly shows that the attachment of NBD, but not dansyl, increases the susceptibility of ceramide to alkaline and neutral enzyme, and decreases that to acid enzymes. Thus the use of this substrate provides a specific and sensitive assay for alkaline and neutral ceramidases.  (+info)

(2/51) Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis.

We previously reported the purification and characterization of a novel type of alkaline ceramidase from Pseudomonas aeruginosa strain AN17 (Okino, N., Tani, M., Imayama, S., and Ito, M. (1998) J. Biol. Chem. 273, 14368-14373). Here, we report the molecular cloning, sequencing, and expression of the gene encoding the ceramidase of this strain. Specific oligonucleotide primers were synthesized using the peptide sequences of the purified ceramidase obtained by digestion with lysylendopeptidase and used for polymerase chain reaction. DNA fragments thus amplified were used as probes to clone the gene encoding the ceramidase from a genomic library of strain AN17. The open reading frame of 2,010 nucleotides encoded a polypeptide of 670 amino acids including a signal sequence of 24 residues, 64 residues of which matched the amino acid sequence determined for the purified enzyme. The molecular weight of the mature enzyme was estimated to be 70,767 from the deduced amino acid sequence. Expression of the ceramidase gene in Escherichia coli, resulted in production of a soluble enzyme with the identical N-terminal amino acid sequence. Recombinant ceramidase was purified to homogeneity from the lysate of E. coli cells and confirmed to be identical to the Pseudomonas enzyme in its specificity and other enzymatic properties. No significant sequence similarities were found in other known functional proteins including human acid ceramidase. However, we found a sequence homologous to the ceramidase in hypothetical proteins encoded in Mycobacterium tuberculosis, Dictyostelium discoideum, and Arabidopsis thaliana. The homologue of the ceramidase gene was thus cloned from an M. tuberculosis cosmid and expressed in E. coli, and the gene was demonstrated to encode an alkaline ceramidase. This is the first report for the cloning of an alkaline ceramidase.  (+info)

(3/51) Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death.

Tumor necrosis factor (TNF) signals cell death and simultaneously induces generation of ceramide. To evaluate the contribution of ceramide to TNF-dependent cell death, we generated clones of the TNF-sensitive cell line L929 that constitutively overexpress human acid ceramidase (AC). Ceramidase, in concert with sphingosine kinase, metabolizes ceramide to sphingosine-1-phosphate (SPP), an inducer of proliferation. In response to TNF, parental L929 cells display a significant increase in intracellular ceramide correlated with an "atypical apoptosis" characterized by membrane blebbing, DNA fragmentation and degradation of poly(ADP-ribose) polymerase despite a lack of caspase activity. These features are strongly reduced or absent in AC-overexpressing cells. Pharmacological suppression of AC with N-oleoylethanolamine restored the accumulation of intracellular ceramide as well as the sensitivity of the transfectants to TNF, implying that an enhanced metabolization of intracellular ceramide by AC shifts the balance between intracellular ceramide and SPP levels towards cell survival. Correspondingly, inhibition of ceramide production by acid sphingomyelinase also increased survival of TNF-treated L929 cells.  (+info)

(4/51) Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.

We examined the biological effects of the ceramide analogues (1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol (D-e-MAPP) and (1R,2R)-2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol (D-NMAPPD) on human HaCaT keratinocytes and human melanoma cells. We could demonstrate that D-e-MAPP and D-NMAPPD are able to suppress acid ceramidase activity. The elevation of the endogenous level of ceramide is followed by induction of apoptosis and suppression of proliferation in HaCaT keratinocytes. Moreover, we recently identified a group of human melanoma cell populations which are heterogeneously susceptible to C2-ceramide-mediated apoptosis. Studies with these melanoma cells revealed correlation between ceramide-mediated apoptosis and D-NMAPPD-induced apoptosis, confirming the effect of this inhibitor on ceramide signaling in human melanoma cells. These findings suggest ceramidase inhibitors as a potential new therapeutical class of antiproliferative and cytostatic drugs.  (+info)

(5/51) The reverse activity of human acid ceramidase.

An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide hydrolysis, the purified enzyme was able to catalyze ceramide synthesis using [14C]lauric acid and sphingosine as substrates. Herein we report detailed characterization of this acid ceramidase-associated "reverse activity" and provide evidence that this reaction occurs in situ as well as in vitro. The pH optimum of the reverse reaction was approximately 5.5, as compared with approximately 4.5 for the hydrolysis reaction. Non-ionic detergents and zinc cations inhibited the activity, whereas most other cations were stimulatory. Of note, sphingomyelin also was very inhibitory toward this reaction, whereas the anionic lipids, phosphatidic acid and phosphatidylserine, were stimulatory. Of various sphingosine stereoisomers tested in the reverse reaction, only the natural, D-erythro form could efficiently serve as a substrate. Using D-erythro-sphingosine and lauric acid as substrates, the reaction followed normal Michaelis-Menten kinetics. The Km and Vmax values toward sphingosine were 23.75 microM and 208.3 pmol/microg/h, respectively, whereas for lauric acid they were 73.76 microM and 232.5 pmol/microg/h, respectively. Importantly, the reverse activity was reduced in cell lysates from a Farber disease patient to the same extent as the acid ceramidase activity. Furthermore, when 12-(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)) (NBD)-conjugated lauric acid and sphingosine were added to cultured lymphoblasts from a Farber disease patient in the presence of fumonisin B (1), the conversion to NBD-ceramide was reduced approximately 30% when compared with normal cells. These data provide important new information on human acid ceramidase and further document its central role in sphingolipid metabolism.  (+info)

(6/51) Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D.

The role of cathepsin D in stress-induced cell death has been investigated by using ovine fibroblasts exhibiting a missense mutation in the active site of cathepsin D. The cathepsin D (lysosomal aspartic protease) deficiency did not protect cells against toxicity induced by doxorubicin and other cytotoxic agents, neither did it protect cells from caspase activation. Moreover, the cathepsin D inhibitor, pepstatin A, did not prevent stress-induced cell death in human fibroblasts or lymphoblasts. The possible role of lysosomal ceramide or sphingosine-mediated activation of cathepsin D in apoptosis was also excluded by using human cells either overexpressing or deficient in acid ceramidase. However, a normal lysosomal function seems to be required for efficient cell death, as indicated by the finding that fibroblasts from patients with mucolipidosis II were partially resistant to staurosporine, sphingosine and TNF-induced apoptosis, suggesting a key role of lysosomes in cell death.  (+info)

(7/51) Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes.

Extracellular calcium (Ca2+(o)) potently induces the growth arrest and differentiation of human epidermal keratinocytes (HEKs). We report that Ca2+(o) markedly upregulates the human alkaline ceramidase 1 (haCER1) in HEKs; and its upregulation mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs. haCER1 is the human ortholog of mouse alkaline ceramidase 1 that we previously identified. haCER1 catalyzed the hydrolysis of very long-chain ceramides to generate sphingosine (SPH). This in vitro activity required Ca2+. Ectopic expression of haCER1 in HEKs decreased the levels of D-e-C(24:1)-ceramide and D-e-C(24:0)-ceramide but elevated the levels of both SPH and its phosphate (S1P), whereas RNA interference-mediated knockdown of haCER1 caused the opposite effects on the levels of these sphingolipids in HEKs. Similar to haCER1 overexpression, Ca2+(o) increased the levels of SPH and S1P, and this was attenuated by haCER1 knockdown. haCER1 knockdown also inhibited the Ca2+(o)-induced growth arrest of HEKs and the Ca2+(o)-induced expression of keratin 1 and involucrin in HEKs. In addition, the acid ceramidase (AC) was also upregulated by Ca2+(o); and its knockdown attenuated the Ca2+(o)-induced expression of keratin 1 and involucrin in HEKs. These results strongly suggest that upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs by generating SPH and S1P.  (+info)

(8/51) Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans.

 (+info)

*  Carmofur
However, carmofur is a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death ... "Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity". Scientific Reports. 3 ( ...
*  Lysosomal storage disease
... sialic acid storage disease Infantile free sialic acid storage disease Glycogen storage diseases Type II Pompe disease Type IIb ... These are LSDs: Sphingolipidoses Ceramidase Farber disease Krabbe disease Infantile onset Late onset Galactosialidosis ... Cystinosis is an LSD characterized by the abnormal accumulation of the amino acid cystine. Alternatively to the protein targets ... Sphingomyelinase Lysosomal acid lipase deficiency Early onset Late onset Niemann-Pick disease Type A Type B Sulfatidosis ...
*  ASAH1
2003). "Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid ... 2000). "Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death". J. Exp. Med. 192 (5): 601-12 ... 2000). "Human acid ceramidase is overexpressed but not mutated in prostate cancer". Genes Chromosomes Cancer. 29 (2): 137-46. ... 2001). "Human acid ceramidase: processing, glycosylation, and lysosomal targeting". J. Biol. Chem. 276 (38): 35352-60. doi: ...
*  ASAHL
2005). "Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain". Eur. J. Neurosci. 20 (12): 3489- ... This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript ... "Entrez Gene: ASAHL N-acylsphingosine amidohydrolase (acid ceramidase)-like". Human NAAA genome location and NAAA gene details ... Schulze H, Schepers U, Sandhoff K (2008). "Overexpression and mass spectrometry analysis of mature human acid ceramidase". Biol ...
*  IRF8
In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis. IRF8 is highly expressed in ... "IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia". Cancer Res. 71 (8): 2882- ...
*  ACER1
"Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal ... Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene. ACER1 mediates ... Protein, Nucleic Acid, Enzyme. 47 (4 Suppl): 455-62. PMID 11915342. Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers ... Ito M, Okino N, Tani M, Mitsutake S, Mori K (Mar 2002). "[Molecular evolution of neutral ceramidase: signalling molecule and ...
*  N-acylethanolamine acid amide hydrolase
It does have 30% homology with acid ceramidase, sharing a significant portion of its amino acid sequence. NAAA was discovered ... its structural similarity to the more familiar acid ceramidase (AC) and functional similarity to fatty acid amide hydrolase ( ... NAAA's primary structure is nearly identical to that of acid ceramidase (AC), whose only difference is the substitution of Leu ... a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase". The ...
*  ASAH2
"Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase ... Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. GRCh38: Ensembl release 89: ENSG00000188611 - ... 2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113-22. doi:10.1016/S0378-1119(03) ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ...
*  Juvenile idiopathic arthritis
... genetic lysosomal disorder caused by a deficiency of the enzyme acid ceramidase. It has symptoms similar to JIA including ... Alpigiani MG, Ravera G, Buzzanca C, Devescovi R, Fiore P, Iester A.[The use of n-3 fatty acids in chronic juvenile arthritis]. ... However, an increased consumption of omega-3 fatty acids proved to be beneficial in two small studies. Celecoxib has been found ... Will administration of omega-3 unsaturated fatty acids reduce the use of nonsteroidal antirheumatic agents in children with ...
*  Ceramide
... can be further hydrolyzed by acid ceramidase to form sphingosine and a free fatty acid, both of which are able to ... A ceramide is composed of sphingosine and a fatty acid. Ceramides are found in high concentrations within the cell membrane of ... Rotolo JA, Zhang J, Donepudi M, Lee H, Fuks Z, Kolesnick R (2005). "Caspase-dependent and -independent activation of acid ... Anandamide Ceramidase Inhibitors Chemotherapeutic agents Fas ligand Endotoxin homocysteine heat gamma interferon ionizing ...
*  Hugo Moser (scientist)
... and they identified acid ceramidase as the enzyme deficient in Farber's disease. In 1964, Moser returned to the Joseph P. ... Yasuo Kishimoto, who had helped Kuni Suzuki make the discovery of elevated very long chain fatty acids in Adrenoleukodystrophy ... Odone made an independent intellectual computation - namely that the use of erucic acid, which is C-22:1 (C-22 monounsaturated ... Bill Rizzo presented data that showed that adding oleic acid (C-18 monounsaturated) to fibroblast cultures of ALD patients ...
*  Ceramidase
Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned: acid ceramidase (ASAH1) - cell survival neutral ... Ceramidase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.5.1.23 Molecular and Cellular Biology ... Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty ... UT Southwestern researchers showed that introducing ceramidase in diabetic mice returned their insulin sensitivity to normal. ...
*  Daniele Piomelli
Fatty Acid Amide Hydrolase inhibitors), PEA (N-Acylethanolamide Acid Amidase inhibitors), and ceramide (Acid Ceramidase ... "Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity". Science Reports 3:1035. ... "Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in ...
*  ASAH
... acid ceramidase), an enzymatic product of ASAH1, gene mutated in Farber disease. ...
*  Chromosome 8 (human)
... acid ceramidase) 1 ASPH: encoding enzyme Aspartyl/asparaginyl beta-hydroxylase AZIN1: encoding protein Antizyme inhibitor 1 ... fatty acid binding protein 9, testis FAM167A: family with sequence similarity 167, member A FAM203B: family with sequence ...
*  Sphingolipid
A brief, very comprehensible review is given in Gunstone, F. (1996) Fatty Acid and Lipid Chemistry, pp 43-44. Blackie Academic ... Finally, ceramide may be broken down by a ceramidase to form sphingosine. Sphingosine may be phosphorylated to form sphingosine ... Gangliosides have at least three sugars, one of which must be sialic acid. Inositol-containing ceramides, which are derived ... such as a fatty acid.[citation needed] Simple sphingolipids, which include the sphingoid bases and ceramides, make up the early ...
*  Lipid signaling
"Docosahexaenoic acid-derived fatty acid esters of hydroxy fatty acids (FAHFAs) with anti-inflammatory properties". Diabetes. 65 ... Sphingosine (Sph) is formed by the action of ceramidase (CDase) enzymes on ceramide in the lysosome. Sph can also be formed in ... Palmitic acid esters of hydroxy-stearic acids (PAHSAs) are among the most bioactive members able to activate G-protein coupled ... Docosahexaenoic acid ester of hydroxy-linoleic acid (DHAHLA) exert anti-inflammatory and pro-resolving properties. ...
*  Fumonisin B1
Folic acid uptake was dramatically inhibited. Treatment after exposure with folic acid reduced NTD by 50-65%. The risks of ... de formation via de novo sphinganine and fatty acyl-CoA and via sphingosine produced by the breakdown of ceramide by ceramidase ... However, when the tricarbillic acid groups are removed from FB1 by hydrolysis, the resulting product (aminopentol, AP1) doesn't ... whereas the negatively charged tricarbyllic acid groups may interact with the fatty acyl-CoA binding site. Because FB1 also ...
*  List of EC numbers (EC 3)
Rhizopus acid proteinase. Now EC 3.4.23.21, rhizopuspepsin EC 3.4.23.10: Endothia acid proteinase. Now EC 3.4.23.22, ... ceramidase EC 3.5.1.24: choloylglycine hydrolase EC 3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase EC 3.5.1.26: N4-(beta ... polar-amino-acid-transporting ATPase EC 3.6.3.22: nonpolar-amino-acid-transporting ATPase EC 3.6.3.23: oligopeptide- ... Identical to EC 3.5.1.25, N-acetylglucosamine-6-phosphate deacetylase EC 3.5.1.81: N-acyl-D-amino-acid deacylase EC 3.5.1.82: N ...
*  Sphingosine-1-phosphate
Sphingosine can be released from ceramides, a process catalyzed by the enzyme ceramidase. Phosphorylation of sphingosine is ... October 2000). "Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate ... Sphingosine Lipid signaling Sphingosine-1-phosphate receptor family (of 5) S1PR1 S1PR2 FTY720 Lysophosphatidic acid Sattler K, ...
*  ENPP7
Unlike acid and neutral SMases in the intestinal tract that are rapidly inactivated by pancreatic trypsin, alk-SMase is ... neutral ceramidase, and sphingolipid metabolites". Pediatr. Res. 61 (1): 61-6. doi:10.1203/01.pdr.0000250534.92934.c2. PMID ... Besides, ursodeoxycholic acid and probiotic VSL#3 may stimulate the expression of ENPP7 in the intestine. GRCh38: Ensembl ... Liu F, Cheng Y, Wu J, Tauschel HD, Duan RD (April 2006). "Ursodeoxycholic acid differentially affects three types of ...
123MyMD.com and its services are for informational purposes only and are not a substitute for professional medical or health advice, examination, diagnosis, or treatment. Always seek the advice of your physician or other qualified health professionals before starting any new treatment, making any changes to existing treatment, or altering in any way your current exercise or diet regimen. Do not delay seeking or disregard medical advice based on information on this site. Medical information changes rapidly and while 123MyMD.com and its content providers make every efforts to update the content on the site, some information may be out of date. No health information on 123MyMD.com, including information about herbal therapies and other dietary supplements, is regulated or evaluated by the Food and Drug Administration and therefore the information should not be used to diagnose, treat, cure, or prevent any disease without the supervision of a medical doctor.. ...
Thank you for your interest in spreading the word about Haematologica.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Compare N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Sucrose non-fermenting protein (SNF1)-related kinase (SNRK) is a homologue of the yeast Snf1 kinase, mutants of which fail to thrive when provided with non-fermentable carbon sources. In the mouse lung SNRK expression is specific to capillary endothelial cells [63]. SNRK is phosphorylated and activated by the LKB1 serine/threonine-protein kinase that regulates cell polarity and functions also as a tumor suppressor [64]. In view of the vascular abnormalities found in LKB1 null mice LKB1 has been placed in the VEGF signalling pathway [65]. Together, these lines of evidence suggest that SNRK is also in the VEGF signalling pathway.. Monoamine oxidase A (MAOA) degrades amine neurotransmitters including serotonin. MAOA is located on the X chromosome and its upregulation in IPAH suggests a possible involvement in the development IPAH given the female prederiliction of the disease.. Acid ceramidase or N-acylsphingosine amidohydrolase (ASAH1) cleaves ceramide into sphingosine and a free fatty acid. Both ...
Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil, being a lypophilic-masked analog of 5-FU that can be administered orally. Carmofur prodrug is ingested and taken up in the intestine, overcoming the problem of 5-FU degradation by dihydropyrimidine dehydrogenase. Once inside a cell, carmofur prodrug is converted into 5-FU. The mechanism of action of carmofur prodrug is traditionally thought to be the generation of 5-FU. However, carmofur is a highly potent acid ceramidase (AC) inhibitor. Ceramide influences cancer cell survival, growth and death. Inhibition of AC activity sensitizes tumor cells to the effects of antineoplastic agents and radiation. Product marketing for carmofur started in 1981. Carmofur has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients in China, Japan, and Finland for many years. Trials and meta-analyses have confirmed that the drug is ...
The Synthesis and Nanoformulation Core (SNC) will supply ceramide analogs, acid ceramidase (AC) inhibitors, sphingosine kinase inhibitors, and tamoxifen metabol...
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008 ...
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015 ...
An authentic small animal model of Farber disease would greatly facilitate research into disease mechanisms and aid in the development of effective therapies. Unfortunately, a complete knock‐out model of Farber disease resulted in early embryonic lethality (Li et al, 2002) and a reduction of ACDase activity in the ovaries of a conditional knock‐out resulted in oocyte apoptosis (Eliyahu et al, 2012). These data highlight the difficulty in generating mouse models of certain LSDs, in particular the lipid storage disorders. These data also suggest that normal ceramide levels and metabolism are critical for early embryonic development.. Significant progress has been made towards effective therapies for LSDs through the use of recombinant enzyme replacement, bone marrow transplantation (BMT), small molecule drugs and gene therapy. It is likely that Farber disease would be responsive to similar approaches. However, the lack of an authentic animal model of Farber disease has hindered this ...
Conclusions A significant percentage of moderate Farber Disease patients are likely diagnosed as having JIA. Given this finding, it is important to increase awareness of Farber Disease in the pediatric rheumatology community. Differential diagnosis can be made by accounting for the comparatively early onset, progressive symmetric arthritis, presence of subcutaneous nodules at the joints, scalp and/or spine, and an unusual, hoarse cry or voice (due to nodule formation on the larynx) in FD patients. Based on experience with bone marrow transplantation in Farber Disease2, enzyme replacement therapy could resolve or significantly attenuate the arthritis phenotype in patients. Such therapy is currently under development. We propose that Farber Disease can account for specific cases diagnosed as JIA, and that clinically guided genetic screening of the JIA population will reveal patients who can benefit from disease-specific care and treatment.. ...
Introduction. In this study, we evaluated the anticancer activity of DM102 [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivalamide], a novel inhibitor of the enzyme acid ceramidase (AC), a key regulator of ceramide metabolism, in combination with C6-ceramide (C6-cer) in human breast cancer cells. Ceramide, a bioactive sphingolipid and potent enhancer of apoptosis, is known to play a role in chemo- and radiation-induced cell death. AC tempers ceramide-induced apoptosis by hydrolysis, producing sphingosine and free fatty acid, thus reducing intracellular ceramide levels and providing substrate for sphingosine kinase, which converts sphingosine to sphingosine 1-phosphate. AC has emerged as a putative anticancer target following reports of upregulation in prostate cancer and in some breast tumors. In the present work, we determined whether the introduction of an AC inhibitor would enhance the apoptosis-inducing effects of C6-cer in breast cancer cells.. Methods. Cultured breast cancer cells were ...
Sidney Farber (September 30, 1903 - March 30, 1973) was an American pediatric pathologist. He is regarded as the father of modern chemotherapy, and the Dana-Farber Cancer Institute is named after him. He was born in Buffalo, New York to Jewish parents Simon and Matilda (Goldstein) Farber. He was the third oldest of 14 siblings. He was the younger brother of the noted philosopher and University of Buffalo professor Marvin Farber (1901-1980). Sidney Farber graduated from SUNY Buffalo in 1923. In the mid-1920s, Jewish students were often refused admission to US medical schools, prompting him to go to Europe. As Farber was fluent in German, he undertook his first year of medical school at the Universities of Heidelberg and Freiburg in Germany. Having excelled in Germany, Farber entered Harvard Medical School as a second-year student and graduated in 1927. After graduate training in pathology at Peter Bent Brigham Hospital (the predecessor of Brigham and Womens Hospital) in Boston, Massachusetts, ...
This study demonstrates that AC upregulation is a conserved response to radiation therapy across multiple tumor types and AC inhibition can directly improve the clinical response to radiotherapy in vitro and in vivo. IR exposure induced AC upregulation at the mRNA, protein, and enzyme activity level. Dependence of this process on ceramide expression was confirmed by exogenously or endogenously manipulating ceramide levels as well as suppression of IR-stimulated ceramide biogenesis. This observation led to our hypothesis that a critical threshold of intracellular ceramide exists beyond which a mechanism of AC gene transactivation is evoked in order to temper ceramide-mediated cell death. A transcription factor activity array and subsequent RNAi validation revealed that the c-Jun/AP-1 transcription factor significantly induces upregulation of AC following IR through de novo ceramide generation. In our hands, 90 percent of surviving clonal cell populations after 80-Gy IR overexpressed AC, and the ...
Teijaro, J.R., Turner, D., Nam, Q., Wherry, E.J., LeFrançois, L. and Farber, D.L. (2011) Cutting Edge: Tissue-retentive lung memory CD4 T cells mediate optimal protective responses to influenza. J. Immunol. 187:5510-14.. Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J.C., Bickham, K.L., Lerner, H., Goldstein, M., Sykes, M., Kato, T and Farber, D.L. (2013) Distribution and compartmentalization of human circulating and tissue-resident memory T cells. Immunity. 38: 187-197. (Also see preview article in same issue by Neuenhahn and Busch, D.H., "Whole body anatomy of human T cells". Immunity. 38:10-12.). Turner, D.L., Bickham, K.L., Farber, D.L. and Lefrancois, L. (2013) Splenic priming of virus-specific CD8 T cells following influenza infection. J. Virol. 87:4496-506. Turner, D.L., Bickham, K.L., Thome, J.J.T., Kim, C., DOvidio, F., Wherry, E.J. and Farber, D.L. (2014) Lung resident niches for the generation and maintenance of influenza-specific memory T cells. Mucosal ...
The KRAB-zinc finger proteins (KRAB-ZFPs) represent an extremely large, but poorly understood, family of transcriptional regulators in mammals. (Sera) cells, endogenous KRAB-ZFPs do not. Rather, KRAB-ZFPs and KAP1 relocalise to novel nucleoplasmic foci that we possess termed KRAB- and KAP1-connected (KAKA) foci. HP1s can also concentrate in these foci and there is a close spatial […]. ...
Visit Healthgrades for information on Dr. Charles Farber, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Overview (in German). Der Sphingolipidmetabolismus kann virale Infektionen und Immunantworten auf vielen Ebenen beeinflussen. In unserem Masernvirus (MV)-Infektionsmodell des zentralen Nervensystems (ZNS) beobachteten wir bereits die Folgen der sauren Sphingomyelinase (Asm)-Defizienz in Mäusen, nämlich eine verminderte Widerstandsfähigkeit gegenüber viraler Infektion, und entdeckten, dass sowohl genetische Defizienz, als auch pharmakologische Hemmung der Asm die Aktivität CD4+ Foxp3+ regulatorischer T-Zellen (Treg) erhöht (Hollmann et al., J. Immunol, 2016, 197:3130-3141). Nun wollen wir herausfinden, wie assoziierte Reaktionswege und Enzyme, für die teilweise Inhibitoren schon in klinischem Gebrauch sind, genutzt werden können, um den gegenteiligen Effekt zu erreichen, d.h. die antivirale Immunreaktion zu stärken. Vorläufige Daten weisen darauf hin, dass die MV-Infektion durch Inhibition der sauren Ceramidase (Acd) oder der Sphingosin-Kinase-1 gehemmt wird. In der kommenden ...
Team ZipCar, a group of cyclers put together for Dana Farber Cancer Institutes annual Pan Mass Challenge, a grueling bike-a-thon raising money for cancer research and treatment.
A naturally occurring agent with the potential to trigger the body`s own defenses against cancer has been identified by researchers at the Dana Farber Cancer Institute, it was reported
Farber Specialty Vehicles has been awarded U.S. Communities contract for Specialty Vehicles, Equipment and Accessories and any Related Equipment, Supplies and Services.
K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K04708 E1.1.1.102; 3-dehydrosphinganine reductase [EC:1.1.1.102] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K12348 ASAH1; acid ceramidase [EC:3.5.1.23] K12349 ASAH2; neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K04711 ACER3; dihydroceramidase [EC:3.5.1.-] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] ...
Compare neutral ceramidase ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
In June 3, 1948, The New England Journal of Medicine published a study by Sidney Farber, MD, showing that a synthetic compound, 4-aminopteroylglutamic acid (aminopterin), could induce remissions in seriously ill children with acute leukemia.1 Although the study was small-just 16 children-10 showed clinical, hematologic, and pathologic evidence of improvement. Even though the childrens remissions were short-lived, Dr. Farbers findings were so groundbreaking-until then, no drug had proved effective against non-solid tumor cancers-they ushered in the era of chemotherapeutics, chemical agents that could stop cancer cells from growing and replicating, in effect killing them.. Aminopterin was later replaced by methotrexate, a similar but more effective folic acid antagonist with fewer side effects, which is still used today in the treatment of leukemia and other blood and solid tumor cancers. Nevertheless, the results of Dr. Farbers study earned him the title, the Father of Modern ...
The NOOK Book (eBook) of the Brain Magick: Exercises in Meta-Magick and Invocation by Philip H. Farber at Barnes & Noble. FREE Shipping on $25 or more!
Temporary restorations often look almost as good as the final restoration. We want the patients to look at the temporary and say, "Wow! This looks great and feels great." The final restoration will be better. but we need to work this all out in the temporary stage. Because temporary restorations look so good, patients sometimes delay getting a final crown or final bridge on their implants. The problem with that scenario is that bacteria can leak under the temporary restoration and that may affect the health of the implant in the long run. There is a set amount of time that a temporary restoration is designed to last, and people should not go beyond that timeframe. Typically six months is the longest amount of time that I would recommend that a patient keep a temporary restoration. They need to return to the office in a timely manner and get their new, permanent teeth.. Dr. Alan H. Farber. Periodontist. Offices in Hauppauge and Medford, NY. New Patients Welcome. www.longislandperio.com. ...
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized ...
Ceramide as a second messenger is a key regulator in apoptosis and cytotoxicity. Ceramide-metabolizing enzymes are ideal target in cancer chemo-preventive studies. Neutral sphingomyelinase (NSMase), acid ceramidase (ACDase) and glucosyl ceramide synthase (GCS) are the main enzymes in ceramide metabolism. Silymarin flavonolignans are potent apoptosis inducers and silibinin is the most active component of silymarin. This study evaluated the effects of silybin A, silybin B and their 3-O-gallyl derivatives (SGA and SGB) at different concentrations (0-200 micro molar) on ceramide metabolism enzymes in Hep G2 hepatocarcinoma cell line. Cell viability, caspase-3 and 9 activities, total cell ceramide and the activities of ACDase, NSMase and GCS were evaluated. Under silibinin derivatives treatments, cell viability decreased and the activities of caspase-3 and 9 increased in a dose dependent manner among which SGB was the most effective one (P|0.05). Total cell ceramide and the activity of NSMase, the enzyme
Polyarticular arthritis as presenting feature of farber disease: a lysosomal storage disease involving inflammation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name "Kohomba" in Sri Lanka, harvested in Sri Lanka. For fibroblasts, the dataset includes expression profiles for genes encoding hyaluronan synthase 1 (HAS1), hyaluronan synthase 2 (HAS2), hyaluronidase-1 (HYAL1), hyaluronidase-2 (HYAL2), versican, aggrecan, CD44, collagen, type I, alpha 1 (COL1A1), collagen, type III, alpha 1 (COL3A1), collagen, type VII, alpha 1 (COL7A1), matrix metalloproteinase 1 (MMP1), acid ceramidase, basic fibroblast growth factor (bFGF), fibroblast growth factor-7 (FGF7), vascular endothelial growth factor (VEGF), interleukin-1 alpha (IL-1α), cyclooxygenase-2 (cox2), transforming growth factor beta (TGF-β), and aquaporin 3 (AQP3 ...
When David Hahns daughter was in high school, she had to complete an oral-history project on someone with an extraordinary life story.. For Hahn, one person immediately came to mind: Erich Farber.. "He has a story that you really wont find from anyone else," said Hahn, chair of the Department of Mechanical and Aerospace Engineering at the University of Florida. "He was truly remarkable.". Farber, who became a faculty member in the department in 1954 and eventually served as director of UFs Solar Energy and Energy Conversion Laboratory, passed away on April 9. He was 95.. He was a world-renowned expert, cutting-edge researcher and 36-year professor in solar-energy technologies. In addition, he earned military decorations in World War II and served as a mountain-climbing instructor and Boy Scout leader.. "My dad had the ability to do just about anything," said his son, Webb Farber, "and he did.". Erich Farber was passionate about researching and developing solar-energy technologies at a time ...
... is a very competent attorney who has been practicing law for 40 years. Mr. Farber is a Personal Injury lawyer specializing primarily in Motor Vehicle Accidents. He is licensed to practice in the state of Pennsylvania, the U.S. District Court, the Eastern District of Pennsylvania, and the Middle District of Pennsylvania.. Stephen graduated from Penn State University with a BA in Mathematics, and spent a year teaching Junior High School Math to save money for Law School. He earned his Juris Doctor from Temple University School of Law. While in Law School, Stephen had the rare opportunity to prosecute cases, as part of his coursework, when he attended a Prosecution Seminar taught by then District Attorney, Arlen Specter.. Mr. Farber joined Master Weinstein Moyer, P.C. in 1994, after spending several years at two prominent Philadelphia area law firms and seven years as a Partner in his own firm. In his earliest years as an attorney, Mr. Farber practiced Criminal Law in addition to ...
A Board Certified physician in Radiation Oncology, Dr. Leonard Farber has been in private practice for over a decade, recently serving as Chairman of Radiation Oncology at Staten Island University Hospital. Dr. Farber specializes in adult radiation oncology, with particular focus on breast cancer, prostate cancer and gastrointestinal malignancies, lymphomas, head and neck cancers and lung cancers. He is an expert in HDR brachytherapy for various types of cancers, including breast, skin and gynecologic malignancies, and intracranial and body radiosurgery.. After receiving his B.S. and B.A. at the State University of New York at Binghamton, Dr. Farber pursued his M.D. at the Mt. Sinai School of Medicine in New York. Following an internship in internal medicine at Beth Israel Medical Center in New York, he did his residency in Radiation Oncology at the Hospital of the University of Pennsylvania in Philadelphia, where he served as Chief Resident. Dr. Farber is a member of the American Society for ...
Complete information for ACER3 gene (Protein Coding), Alkaline Ceramidase 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for ACER3 gene (Protein Coding), Alkaline Ceramidase 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Volunteer Name: Adam Farber Project Location: Bulenga, Uganda Program Dates: July 2013 (2 weeks) Volunteered At: Orphanage and school What was your favorite memory of this trip? The kids. Theyre so great and so excited to have a guest teacher. Getting to know them over time and watching them learn was a great experience.  What was the most difficult thing you experienced? Figuring out how cautious to be with safety at night. As time went on it seemed fine to be out for a couple hours after dark if walking with a group, especially if with a local. For a later night in Kampala it was also easy to arrange a private driver for a reasonable fee. What was the one thing you wished you were better prepared for? Understanding what to worry about safety-wise. The quick answer is dont worry in Bulenga unless its been dark for a while and all the people have gone home. Of course there is no need to take unnecessary risks either, such as walking alone anytime at night or carrying lots of money or
AbeBooks.com: Power Over Pain: Intelligent Fitness for the Amateur and Professional (9781939550125) by Shereen D D Farber; Debra S Knapp and a great selection of similar New, Used and Collectible Books available now at great prices.
Meet Sex Swapping Couples In Farber-Missouri at lifestylelounge. Are you a swinger in Farber-Missouri? Find local adult sex clubs in Farber-Missouri right here.
SmartBeautyGuide.com will empower you to make the most intelligent decisions about your beauty and connect you with the most qualified Aesthetic plastic surgeon whos right for you.
my husband was in Mercks PD-1 inhibitor ( keytruda) between Jan 2015 and June 2015. He was on the highest dose of 10mg/kg every 2 weeks. At the time, there was no clinical trial that would guarantee he gets a PD-1 inhibitor . There was only one that randomized between avastin or Opdivo blindly and we didnt want to get avastin at the time. Hence, we went with the keytruda study grouping solid tumors together at the highest dose. He never had a swelling. What happened was 2 month after enrolling, he started having subtle enhancements that the NO was not sure whether they are inflammation or recurrence. Things stayed this way with increased enhancements till in June we decided this cant be enhancement and he sat for a craniotomy that confirmed our doubts that this was definetly recurrence with minimal swelling or inflammation. The pathology was confirmed by Both Dana Farber and Johns Hopkins ...
Blogger Euan Semple recently highlighted a key point about Enterprise 2.0 adoption that ZDNets own Dan Farber also found worthy of note over the weekend. And that is that Enterprise 2.0 will happen in your organization entirely by itself, whether you encourage it, discourage it, or even consign it to benign neglect. Euan actually laid out three strategies in semi-tongue cheek form likely meant as a shot across the bow of complacent IT departments; whether you get out of the way, actively encourage it, or do absolutely nothing, Enterprise 2.0 platforms like blogs, wikis, and related social, emergent, freeform Web 2.0-style apps are coming to your company, and in fact are almost certainly there already.
Im here at an AttentionTrust luncheon, featuring a talk by Michael Goldhaber and some AttentionTrust and GestureBank related announcements. Dan Farber is here as well, so check his blog for related coverage (and his photos are included below).
Brownstein Hyatt Farber Schreck is a unique law firm. Walk into any of our offices and youll immediately recognize a different type of energy. Complacency doesnt have a place here. Flexibility and... ...
Petang semalam, mak sedara dia datang umah minta tunjukkan jalan ke Klinik Gigi di Seri Gombak.. so petang tu bawa la si Naufal jalan-jalan sekali.. so untuk asah skill mengambil gambar yang dah tumpul nie, ataicha bawa la kamera.. iya nak asah skill kena laa banyak ambik gambar.. baru dapat skill dalam mencari angle kan... tapi untuk awal-awal ni setting auto je ...
There is less radioactive Cs in wood near Vermont Yankee than in wood from a hundred miles away. Guest post by Stewart Farber, MSPH, explains why.
The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017 ...
A trip to the past and to the future - all in one night.. This festive season, Johns Hopkins University researchers dug deep into their reserves of scientific expertise to explain how these inexplicable plot lines in holiday classics like Rudolph the Red Nosed Reindeer, How the Grinch Stole Christmas, and A Christmas Carol just might be (almost) (possibly) possible:. A biologist explains Rudolphs nose:. Steve Farber, principal investigator at the Carnegie Institution for Science and a Johns Hopkins biology professor. VIDEO: https://www.youtube.com/watch?v=Eb6Ni2BIsn8&feature=youtu.be. Although reindeer noses arent typically red, or infused with enough light to guide a sleighs airspace, Farber says other earthly creatures are that color and glow through bioluminescence or fluorescence - everything from jelly fish to sea anemones to the zebrafish he studies. If genetic material from one of those organisms found a way into Rudolphs DNA, Farber supposes he, too, could glow red - or at least a ...
Hi everyone,. I have been on and off this site.. My husband was diagnosed with GBM in March 2012. We have had our fair amount of ups and downs, MRIs showing improvement and then spread. We live in Massachusetts and I brought my husband to Brigham and Womens, as well as Dana Farber - having seen one of the most knowledgeable doctors in the Boston area, who is from Duke University. There has been some forgetfulness, etc. There has been some increasing forgetfulness, but its funny how the brain is able to find new paths. We lost my father-in-law unexpectedly 2 days after Christmas. We had been on Temodar as most GBM patients start with. Initially, it was helping and there was shrinkage. My husband has 3 tumors, all inoperable. Our last trip to Dana Farber, he was hospitalized at BWH and had an MRI around 9/25/2012, which showed spread to the brain stem, left side of brain (original tumors on right), "fingers", and some suspicious cells in his CSF - this was a shock to us because he had been doing ...
A 45 year old Black female without significant past medical history was admitted with insidious cough, dyspnea, nausea, vomiting, and progressive weight loss. She suddenly went into respiratory distress and succumbed to death. Autopsy subsequently showed widespread granulomatous disease. This slide of one of the lung lesions shows a noncaseating granulocyte with a fibrotic center surrounded by palisading histiocytes, consistent with a diagnosis of nodular sarcoma.
Gary Farbers twisted take on politics, news, science fiction fandom, science, technology, culture, style, history, and everything weird, in one Singularity. With a little sex. Yknow, for the kids.
Gary Farbers twisted take on politics, news, science fiction fandom, science, technology, culture, style, history, and everything weird, in one Singularity. With a little sex. Yknow, for the kids.
The images showed some "thickening" on the optic nerve on Cams right eye. In addition, there was some "linear enhancement" on her spine. While there is no specific tumor growth that they can identify - this is a change from her June MRI and is enough cause for concern to NOT cancel her September appointments. They would like to repeat the MRI and see Cam in the BTC at Dana Farber. In addition, they she will have another spinal tap to run cytology (check for cancer cells in her CSF). This, however, cannot be done until after they see the MRI to make sure that it is safe to do so - if you do an LP and there is tumor present, the decrease in CSF can cause the brain to "drop" and make matters worse. There are also some less dire possibilities - radiation scarring (though unlikely due to the location being outside the radiation field), meningitis scarring - but given Cams history, they are going to take a very cautious approach and make sure that no stone goes unturned ...
The Berry Family partnered with the Jimmy Fund at Dana Farber starting in 2009 in an effort to raise money for cancer research. Over the course of the 3 years, we have raised a little over $95,000. It was Michael Berrys wish to find a cure for ...
Dr. Alfred DeMaria, Assistant Commissioner of Communicable Disease, Massachusetts Department of Public Health and Dr. Arthur Pardee of the Dana Farber ...
The next day, Farber got approval to cover the story. He received a phone call from the Air Force saying they could take him as far as Munich where he could cover the Air Force evacuation of refugees to the United States.. "But they knew well," Farber said, "that you couldnt take American journalists that close to the Hungarian border and not turn us loose.". It was Christmas night of 1956 when Farber reached the Austria-Hungary border. It wasnt long, however, before the journalists including Farber found a new purpose to be there.. "Ive never seen anything like this," Farber said. "When we got to the border we were journalists, but when we saw what [was] going on, all the journalists put their pencils and papers and cameras away, and instead of taking notes, they were lifting babies out of rafts.". The people fleeing Hungary were filled with gratitude, Farber said. "They were kissing the ground of the free world.". It was at the Einser Canal that Farber joined the "Freedom Navy" volunteers ...
How are expert educators using games in their classrooms to give students agency, while also teaching twenty-first century skills, like empathy, systems thinking, and design thinking? This question has motivated Matthew Farbers Game-Based Learning in Action: How an Expert Affinity Group Teaches With Games showcasing how one affinity group of K12 educators-known as "The Tribe"-teaches with games. They are transformational leaders outside the classroom, in communities of practice. They mentor and lead newcomers to game-based learning, as well as advise game developers, academics, and policymakers. Teachers in "The Tribe" do not teach in isolation-they share, support, and mentor each other in a community of practice. Farber shares his findings about the social practices of these educators. Game-Based Learning in Action details how the classrooms of expert game-based learning teachers function, from how they rollout games to how they assess learning outcomes. There are plenty of lessons to be ...
Colleen L Fox MD - Jacob Calvert MD - Michael S Farber MD, the Top Vancouver Gynecologists Handpicked using our proprietary 50-Point inspection.
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Cardiovascular disease (26%) and cancer (22%) were the most common causes of death during the long-term follow-up of patients with aSAH. Among general Finnish population, the rates are 30% and 23%, respectively.26 Interestingly, even patients ,65 years had cardiovascular disease as their leading cause of death (26%). This finding differed from general Finnish population of ,65 year olds (cardiovascular disease death, 19%).26 The patients with aSAH may have increased mortality because of cardiovascular disease, especially at younger ages. The recent study on 1765 patients with aSAH made similar conclusions in stating that increased risk of vascular disease and death are pronounced in younger patients.15 A previous Finnish study on 1537 patients with aSAH suggested that aSAH can be a manifestation of general vascular disease.12 This is indeed 1 possible explanation, but the risk of cardiovascular disease may also be because of the impact of SAH on the cardiovascular system or because of shared ...
Gentaur molecular products has all kinds of products like :search , Ray Biotech \ Recombinant Human Acid Phosphatase-1 \ 228-10010-1 for more molecular products just contact us
Tracy Farber, in the opening third of the novel, goes from describing herself not just as single but as "retired" from the dating game, to being head over heels for a man who seems, according to the constructs of the love story, to be the One. George -- tall, sensitive and handsome -- offers an engaging counterpoint to Tracys cultural Judaism and casual liberalism: Hes a former fundamentalist Christian who began his career in finance after immigrating to New York from Canada. But with him, Tracy is not the "kind of happy" with which shed grown familiar, but the "preposterous-happy" shed assumed was unrealistic to expect. In addition, she finds his personal happiness -- a brand manifest "not because his life has been happy, but because he knows its important to be" -- refreshingly mature and conveniently in line with her anti-Tolstoy thesis. ...
The following are recordings of selected presentations from the departments seminar series, held on Fridays from 12 to 12:55 p.m. in room 144 Farber Hall. See the archived recordings page for additional recordings.. ...
... Niemann Pick Disease is an autosomal recessively inherited disease caused by the deficiency of sphingomyelinase enzyme, leading to the accumulation of sphingomyelin. It is charecterised by severe CNS
... Niemann Pick Disease is an autosomal recessively inherited disease caused by the deficiency of sphingomyelinase enzyme, leading to the accumulation of sphingomyelin. It is charecterised by severe CNS
Buy our Recombinant human Acid Phosphatase protein. Ab87493 is an active full length protein produced in Escherichia coli and has been validated in FuncS…
Reviews and evaluates psychological studies of separately raised identical twins and suggests which aspects of human experience are largely shaped by ones heredity
Now, Dr. Ho, Dr. Farber, now at the Carnegie Institution of Washington, and Dr. Pack at the University of Pennsylvania School of Medicine, have found a gene, which they dubbed fat free. Reporting in the April issue of the journal Cell Metabolism, the team explains that disrupting the gene interferes with the ability to absorb lipids through the intestine. These fish die when they are about a one and half weeks old because of this defect, even though they look normal and swallow properly ...
New work led by Carnegies Steven Farber sheds light on how form follows function for intestinal cells responding to high-fat foods that are rich in cholesterol and triglycerides.
J.P. Brady, P.J. Farber, A. Sekhar, Y.-H. Lin, R. Huang, A. Bah, T.J. Nott, H.S. Chan, A.J. Baldwin, J.D. Forman-Kay and L.E. Kay (2017). Structural and Hydrodynamic Properties of An Intrinsically Disordered Region of A Germ-Cell Specific Protein on Phase Separation. Proceedings of the National Academy of Sciences, USA 114, E8194-E8203 [Download combined pdf file for Main Text & Supporting Information ...
Abiola, O and Angel, JM and Avner, P and Bachmanov, AA and Belknap, JK and Bennett, B and Blankenhorn, EP and Blizard, DA and Bolivar, V and Brockmann, GA and Buck, KJ and Bureau, JF and Casley, WL and Chesler, EJ and Cheverud, JM and Churchill, GA and Cook, M and Crabbe, JC and Crusio, WE and Darvasi, A and de Haan, G and Demant, P and Doerge, RW and Elliott, RW and Farber, CR and Flaherty, L and Flint, J and Gershenfeld, H and Gibson, JP and Gu, J and Gu, W and Himmelbauer, H and Hitzemann, R and Hsu, HC and Hunter, K and Iraqi, FA and Jansen, RC and Johnson, TE and Jones, BC and Kempermann, G and Lammert, F and Lu, L and Manly, KF and Matthews, DB and Medrano, JF and Mehrabian, M and Mittleman, G and Mock, BA and Mogil, JS and Montagutelli, X and Morahan, G and Mountz, JD and Nagase, H and Nowakowski, RS and OHara, BF and Osadchuk, AV and Paigen, B and Palmer, AA and Peirce, JL and Pomp, D and Rosemann, M and Rosen, GD and Schalkwyk, LC and Seltzer, Z and Settle, S and Shimomura, K and Shou, ...
Abiola, O and Angel, JM and Avner, P and Bachmanov, AA and Belknap, JK and Bennett, B and Blankenhorn, EP and Blizard, DA and Bolivar, V and Brockmann, GA and Buck, KJ and Bureau, JF and Casley, WL and Chesler, EJ and Cheverud, JM and Churchill, GA and Cook, M and Crabbe, JC and Crusio, WE and Darvasi, A and de Haan, G and Demant, P and Doerge, RW and Elliott, RW and Farber, CR and Flaherty, L and Flint, J and Gershenfeld, H and Gibson, JP and Gu, J and Gu, W and Himmelbauer, H and Hitzemann, R and Hsu, HC and Hunter, K and Iraqi, FA and Jansen, RC and Johnson, TE and Jones, BC and Kempermann, G and Lammert, F and Lu, L and Manly, KF and Matthews, DB and Medrano, JF and Mehrabian, M and Mittleman, G and Mock, BA and Mogil, JS and Montagutelli, X and Morahan, G and Mountz, JD and Nagase, H and Nowakowski, RS and OHara, BF and Osadchuk, AV and Paigen, B and Palmer, AA and Peirce, JL and Pomp, D and Rosemann, M and Rosen, GD and Schalkwyk, LC and Seltzer, Z and Settle, S and Shimomura, K and Shou, ...
That is a good hospital and then there is Dana Farber, in Mass. that has a good reputation. Please keep me posted on how things are going and progressing and what and where you descried on treatment. Sometimes we have to make the most difficult decisions when we simply are not at our best to do so; but be assured of my prayers and heart felt thought. Your friend and, Warmly, lillian We invite you to take a look at our Album. www.angelfire.com/sc/molangels/index.html ( Very informational, good tips, Molers pictures, art work and much more.... ----- Original Message ----- From: ,[email protected], To: ,[email protected], Sent: Saturday, October 30, 1999 10:32 AM Subject: Re: [MOL] Stereotactic Radiosurgery/June , Dear Liilian, , Thank you for your response it is true Kenny and I both thought we had beat , this,we were terribly disappointed when we got the news. Oct of last year , Kenny had surgery in his upper intestine and the cancerous portion was , removed the lymphnodes were involved a ...
MARKERS II The Journal o f the Association for Gravestone Studies UNIVERSITY PRESSOF AMERICA MARKERS II The Journal of the Association for Gravestone Studies David Watters, Editor UNIVERSITY PRESS OF AMERICA )RK Copyright © 1983 by University Press of America,™ Inc. 4720 Boston Way Lanham, MD 20706 3 Henrietta Street London WC2E 8LU England All rights reserved Printed in the United States of America ISBN (Perfect): 0-8191-3464-3 ISBN (Cloth): 0-8191-3463-5 Co-published by arrangement with the Association for Gravestone Studies Dedicated to Jessie Lie Farber Daniel Farber 111 IV ASSOCIATION FOR GRAVESTONE STUDIES EDITORIAL BOARD David Watters, Editor F. Joanne Baker Jessie Lie Farber Peter Benes James A. Slater Manuscripts may be submitted for review for future volumes to the editor, Department of English, University of New Hampshire, Durham, NH 03824. Manuscripts should conform to the MLA Stylesheet and be accompanied by glossy black and white prints or black ink drawings. Copies of MARKERS I ...
What researchers have found is that when you use a proteasome inhibitor, immunomodulator, and steroid, such as in this case RVd (Revlimid, Velcade, and dexamethasone), the response rates are remarkably high. In the Dana Farber led Phase 1/2 multi-center study published in 2010 in Blood, a response rate of 100% with 50% of patients obtaining a complete remission was shown. For those patients in this study that went on to transplant, no advantage in progression free survival at 18 months was observed compared to those who did not undergo transplant . This gave Dana Farber and their partners the impetus to conduct a larger Phase 3 trial, in collaboration with their colleagues in the Intergroupe Francophone du Myelome (IFM), knowing that with such an active regimen of RVd they needed to investigate further what role transplant should take in myeloma treatment. In this current Phase 3 trial they are looking at using the RVd regimen either before stem cell mobilization with chemotherapy with a long ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies. ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Obesity and aversion to exercise have become hallmarks of modern society -- and a new study suggests that a blood protein linked to these lifestyle factors may be an indicator for an increased risk of developing pancreatic cancer. Researchers from the Dana Farber Cancer Institute report their findings in the Aug. 15 issue of Cancer Research, a journal of the American Association for Cancer Research.
Numerous studies in the fields of heart disease and diabetes have shown the benefits of nut consumption, and we felt that it was important to determine if these benefits could also apply to colorectal cancer patients," said lead study author Temidayo Fadelu, a clinical fellow in medicine at Dana Farber Cancer Institute in Boston, Massachusetts, US ...
Elementary Statistics: Picturing the World (6th Edition) answers to Chapter 3 - Probability - Section 3.1 Basic Concepts of Probability and Counting - Exercises - Page 144 70 including work step by step written by community members like you. Textbook Authors: Larson, Ron; Farber, Betsy, ISBN-10: 0-32191-121-0, ISBN-13: 978-0-32191-121-6, Publisher: Pearson
Elementary Statistics: Picturing the World (6th Edition) answers to Chapter 3 - Probability - Section 3.1 Basic Concepts of Probability and Counting - Exercises - Page 143 58 including work step by step written by community members like you. Textbook Authors: Larson, Ron; Farber, Betsy, ISBN-10: 0-32191-121-0, ISBN-13: 978-0-32191-121-6, Publisher: Pearson
Debora B. Farber is a biochemist and molecular biologist who has been a faculty member of the UCLA School of Medicine since she joined the Department of Ophthalmology in 1977. She became a full professor in 1984, a Karl Kirchgessner Endowed Chair in 2001 and a Distinguished Professor in 2007. She has been Associate Director for Research of the Brain Research Institute (1992 -1994) and Associate Director of the Jules Stein Eye Institute as well as Co-Chief of its Vision Science Division (1994 2004). Dr. Farber earned her M.S. in Chemistry and her Ph.D. in Organic Chemistry at the University of Buenos Aires, Argentina. She was a postdoctoral fellow in the Chemistry Department, University of California at Santa Barbara, where she studied the cyclic nucleotide regulation of different processes. She started working on the retina and diseases affecting it when she joined UCLA, and soon thereafter she received a National Eye Institute Research Career Development Award. In addition to her continued ...
Dermatophilus congolensis is a gram positive bacterium which causes a skin disease in a wide range of animals including man. This disease is called dermatophilosis, commonly known as rain rot. Dermatophilosis causes extensive damage within the animal industry, including loss of days at work, reduction in milk yield, and deterioriation of hide and meat quality. This disease requires quick diagnostic tools and sustainable treatment to avoid economic losses. ^ The 1029 bp DNA segment of the alkaline ceramidase gene of D. congolensis was targeted to develop a species-specific PCR to speed up the diagnostic and treatment process to minimize economic losses. The PCR is sensitive, specific and detects as low as 50 × 10-3µg of D. congolensis DNA within 4 hours. This PCR has potential clinical application for rapid diagnosis of dermatophilosis. ^ Caprylic acid is a medium chain fatty acid that contains 8 carbons in its structure. Caprylic acid and its derivatives, namely monocaprylin and sodium caprylate, are
A rapid purification method was developed to isolate milligram quantities of human acid sphingomyelinase from the media of overexpressing Chinese hamster ovary cells. The purified, recombinant enzyme (rhASM) had physical and kinetic characteristics t
Dedicated to Artists books, multiples, recordings, postcards, magazines and ephemera, this site will feature reviews of recent titles, features on artists and publishers, random listings of older works, the occasional longer essay or interview, straight-forward pictorials, links to recent news, etc. etc., in an attempt to create an aggregate of information on editioned artworks ...
Celia Farber at The Truth Barrier interviews Professor of Molecular Biology and Rethinking AIDS board member Marco Ruggiero: "Everything about Ruggiero was improbable; A full Professor of Molecular Biology, Department of Experimental Pathology and Oncology at the University of Firenze, Italy, who suddenly appeared on the HIV/AIDS scene as somebody in whom the blood-soaked distinction between orthodox and dissident appeared to have dissolved. He was both. That is to say, he came from extremely mainstream, indeed orthodox channels, yet when he dissented from said orthodoxy on the question of HIVs pathogenesis, he apparently did so not only without trauma, but to the sound of cheering, from his Italian colleagues and peers.". ...
Markedly perturbed hematopoiesis in acid ceramidase deficient mice | Haematologica  Markedly perturbed hematopoiesis in acid ceramidase deficient mice | Haematologica
Markedly perturbed hematopoiesis in acid ceramidase deficient mice. Shaalee Dworski, Alexandra Berger, Caren Furlonger, Joshua ... Markedly perturbed hematopoiesis in acid ceramidase deficient mice. Shaalee Dworski, Alexandra Berger, Caren Furlonger, Joshua ... Markedly perturbed hematopoiesis in acid ceramidase deficient mice Message Subject (Your Name) has forwarded a page to you from ... Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis ...
more infohttp://www.haematologica.org/content/early/2015/02/09/haematol.2014.108530
Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells |...  Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells |...
Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells. ... Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells ... Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells ... Abstract 5484: Targeted inhibition of acid ceramidase and C6-ceramide exposure induces synergistic killing in cancer cells ...
more infohttp://cancerres.aacrjournals.org/content/71/8_Supplement/5484
123MyMD » Acid Ceramidase  123MyMD » Acid Ceramidase
123MyMD.com and its services are for informational purposes only and are not a substitute for professional medical or health advice, examination, diagnosis, or treatment. Always seek the advice of your physician or other qualified health professionals before starting any new treatment, making any changes to existing treatment, or altering in any way your current exercise or diet regimen. Do not delay seeking or disregard medical advice based on information on this site. Medical information changes rapidly and while 123MyMD.com and its content providers make every efforts to update the content on the site, some information may be out of date. No health information on 123MyMD.com, including information about herbal therapies and other dietary supplements, is regulated or evaluated by the Food and Drug Administration and therefore the information should not be used to diagnose, treat, cure, or prevent any disease without the supervision of a medical doctor.. ...
more infohttp://www.123mymd.com/dictionary/acid-ceramidase-2/
KEGG BRITE: KEGG Orthology (KO) - Equus caballus (horse)  KEGG BRITE: KEGG Orthology (KO) - Equus caballus (horse)
... acid ceramidase [EC:3.5.1.23] K12349 ASAH2; neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] ... 100063894 ACER2; alkaline ceramidase 2 100147512 ACER1; alkaline ceramidase 1 100063572 ACER3; alkaline ceramidase 3 100049834 ... K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K04711 ACER3; dihydroceramidase [EC:3.5.1.-] K04712 DEGS; sphingolipid 4- ...
more infohttp://www.genome.jp/kegg-bin/get_htext?ecb00001+100146641
Upregulated Genes In Sporadic, Idiopathic Pulmonary Arterial Hypertension | Respiratory Research | Full Text  Upregulated Genes In Sporadic, Idiopathic Pulmonary Arterial Hypertension | Respiratory Research | Full Text
Acid ceramidase or N-acylsphingosine amidohydrolase (ASAH1) cleaves ceramide into sphingosine and a free fatty acid. Both ... Acid ceramidase was identified as upregulated in both our SSH and this microarray study, suggesting that upregulation of this ... that catalyzes the oxidative decarboxylation of pyruvate and is located at the interface between glycolysis and the citric acid ...
more infohttps://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-7-1
Farber disease: understanding a fatal childhood disorder and dissecting ceramide biology | EMBO Molecular Medicine  Farber disease: understanding a fatal childhood disorder and dissecting ceramide biology | EMBO Molecular Medicine
Li CM, Park JH, He X, Levy B, Chen F, Arai K, Adler DA, Disteche CM, Koch J, Sandhoff K, et al (1999) The human acid ceramidase ... Acid ceramidase (ACDase) is a soluble lysosomal enzyme responsible for the breakdown of ceramide to sphingosine and fatty acid ... Acid ceramidase has also been shown to be involved in the resistance of certain tumor cells to chemotherapeutic agents and has ... Park JH, Schuchman EH (2006) Acid ceramidase and human disease. Biochim Biophys Acta 1758: 2133‐ 2138 ...
more infohttp://embomolmed.embopress.org/content/5/6/799
AB0880 Farber Disease Diagnosed as Juvenile Idiopathic Arthritis | Annals of the Rheumatic Diseases  AB0880 Farber Disease Diagnosed as Juvenile Idiopathic Arthritis | Annals of the Rheumatic Diseases
... is an ultra-rare lysosomal storage disorder resulting from the inherited deficiency of the enzyme acid ceramidase, and the ...
more infohttp://ard.bmj.com/content/73/Suppl_2/1092.2
ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase Antibody (AF4886): Novus Biologicals  ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase Antibody (AF4886): Novus Biologicals
Goat Polyclonal Anti-ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase Antibody. Validated: WB, IP. Tested Reactivity: Mouse. ... and is structurally similar to acid ceramidase (1). NAAA is both a lysosomal and a secreted enzyme, and like acid ceramidase, ... Alternate Names for ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase Antibody. *Acid ceramidase-like protein ... Additional ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase Products. ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase AF4886 ...
more infohttps://www.novusbio.com/products/asahl-n-acylethanolamine-hydrolyzing-acid-amidase-antibody_af4886
Acid Ceramidase ELISA Kits | Biocompare.com  Acid Ceramidase ELISA Kits | Biocompare.com
Compare Acid Ceramidase ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and ... Acid Ceramidase ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting and ... Your search returned 15 Acid Ceramidase ELISA ELISA Kit across 3 suppliers. ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-4623/ELISA_Kit/ELISA_Acid_Ceramidase
Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues  Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues
The most potent in vitro inhibitor of acid ceramidase, B-13, recently revealed to be virtually inactive towards lysosomal acid ... ω-position of the fatty acid moiety of B-13 led to a significant reduction of potency towards acid ceramidase from cellular ... Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues. Denny Proksch, Jan Jasper Klein, and Christoph Arenz ... Indeed, inhibitors of acid ceramidase have been reported to induce cell death and to display potentiating effects to classical ...
more infohttps://www.hindawi.com/journals/jl/2011/971618/abs/
Blockade of Lysosomal Acid Ceramidase Induces GluN2B-Dependent Tau Phosphorylation in Rat Hippocampal Slices  Blockade of Lysosomal Acid Ceramidase Induces GluN2B-Dependent Tau Phosphorylation in Rat Hippocampal Slices
... Marie-Elaine ... "Blockade of Lysosomal Acid Ceramidase Induces GluN2B-Dependent Tau Phosphorylation in Rat Hippocampal Slices," Neural ...
more infohttps://www.hindawi.com/journals/np/2014/196812/cta/
extended treatment with an acid ceramidase inhibitor modulates the metabolism of ceramide and selects for a radiation-resistant...  extended treatment with an acid ceramidase inhibitor modulates the metabolism of ceramide and selects for a radiation-resistant...
H9 cells, a human T cell lymphoma cell line, were cultured in medium with the acid ceramidase inhibitor N-oleoyl-ethanolamine ( ... extended treatment with an acid ceramidase inhibitor modulates the metabolism of ceramide and selects for a radiation-resistant ... extended treatment with an acid ceramidase inhibitor modulates the metabolism of ceramide and selects for a radiation-resistant ... extended treatment with an acid ceramidase inhibitor modulates the metabolism of ceramide and selects for a radiation-resistant ...
more infohttp://cancerres.aacrjournals.org/content/66/8_Supplement/1033.2
Faculty Collaboration Database - Acid ceramidase confers radioresistance to glioblastoma cells.  Oncol Rep 2017 Oct;38(4):1932...  Faculty Collaboration Database - Acid ceramidase confers radioresistance to glioblastoma cells. Oncol Rep 2017 Oct;38(4):1932...
Acid Ceramidase. Brain Neoplasms. Cell Line, Tumor. Glioblastoma. Humans. Immunohistochemistry. Lysophospholipids. Neoplasm ... Acid ceramidase confers radioresistance to glioblastoma cells. Oncol Rep 2017 Oct;38(4):1932-1940 PMID: 28765947 PMCID: ... This study demonstrates that GBMs acquire resistance to radiation via upregulation of acid ceramidase (ASAH1) and sphingosine‑1 ...
more infohttps://fcd.mcw.edu/?module=search&func=showPublication&id=751538
NAVER Academic | A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid...  NAVER Academic | A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid...
... which can systemically deliver siRNA targeting the acid ceramidase (AC) gene for cancer therapy. This triblock copolymer, ... A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for ... siRNA delivery, Cancer therapy, Acid ceramidase, Micelleplex, Polyphosphoester, genetics, Animals, Apoptosis, Biocompatible ... which can systemically deliver siRNA targeting the acid ceramidase (AC) gene for cancer therapy. This triblock copolymer, ...
more infohttps://academic.naver.com/article.naver?doc_id=64842095
Life Science/Diagnostics  Life Science/Diagnostics
Novel Acid Ceramidase inhibitors, and their use as anti-tumor and anti-inflammatory agents. Novel anti-tumor and anti- ... Acid Ceramidase inhibitors, and their use as anti-tumor and anti-inflammatory agents. Anti-tumor and anti-inflammatory agents ... Acid ceramidase inhibitors and their use as medicaments. The present invention concerns, in a first aspect, compounds of ... Acid ceramidase inhibitors and their use as medicaments. The present invention relates to compounds of Formula I, its ...
more infohttps://iit.it/technology-transfer/technology-transfer-patents/life-science-diagnostics
Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer...  Molecular analyses of novel ASAH1 mutations causing Farber lipogranulomatosis: analyses of exonic splicing enhancer...
5′ splice site; ASAH1; Farber disease; acid ceramidase; exon skipping; exonic splicing enhancer; polypyrimidine tract ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24355074
IJMS | Free Full-Text | Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance  IJMS | Free Full-Text | Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance
This review also provides an overview of a novel marker called acid ceramidase and its implication in the development of ... Keywords: glioblastoma; acid ceramidase; acid ceramidase inhibitors; carmofur; radioresistance; radiation; sphingosine; ... acid ceramidase; acid ceramidase inhibitors; carmofur; radioresistance; radiation; sphingosine; sphingosine-1-phosphate; S1P ... This review also provides an overview of a novel marker called acid ceramidase and its implication in the development of ...
more infohttp://www.mdpi.com/1422-0067/19/6/1765
IJMS | Free Full-Text | Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel...  IJMS | Free Full-Text | Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel...
... acid ceramidase; multidrug resistance; autophagy melanoma; sphingolipids; ceramides; acid ceramidase; multidrug resistance; ...
more infohttps://www.mdpi.com/1422-0067/20/14/3436
KEGG ENZYME: 3.5.1.23  KEGG ENZYME: 3.5.1.23
acid ceramidase. K12349 neutral ceramidase. Genes. .g1{display:none;}. HSA: 125981(ACER1) 340485(ACER2) 427(ASAH1) 56624(ASAH2) ...
more infohttp://www.genome.jp/dbget-bin/www_bget?enzyme+3.5.1.23
D3 Validation  D3 Validation
Acid ceramidase (AC). AC is a cysteine amidase that degrades the sphingolipid messenger ceramide, into sphingosine and fatty ... Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature ... N-acylethanolamine acid amidase (NAAA). NAAA is a cysteine amidase that catalyzes the degradation of two endogenous analgesic ... Peripherally restricted fatty acid amide hydrolase (FAAH) inhibitors. FAAH is a serine amidase that degrades the endogenous ...
more infohttps://iit.it/research/lines/d3-validation
  • Detects mouse ASAHL/N‑acylethanolamine-hydrolyzing Acid A in direct ELISAs and Western blots. (novusbio.com)
  • However, introduction of weakly basic groups at the ω -position of the fatty acid moiety of B-13 led to a significant reduction of potency towards acid ceramidase from cellular extracts. (hindawi.com)
  • Peripherally restricted fatty acid amide hydrolase (FAAH) inhibitors. (iit.it)
  • Determination of Double Bond Positions in Polyunsaturated Fatty Acids using the Photochemical Paternò-Büchi Reaction with Acetone and Tandem Mass Spectrometry. (lipidmaps.org)
  • Indeed, inhibitors of acid ceramidase have been reported to induce cell death and to display potentiating effects to classical radio- or chemo therapy in a number of in vitro and in vivo cancer models. (hindawi.com)
  • The invention relates to the field of molecular biology.The invention relates to the field of molecular biology.More particularly, the invention relates to a methodand a kit for the colorimetric detection of a targetnucleic acid in a sample in which the target nucleicacid is present in mixture with other sample materials,including other acids nucleics that differ from thetarget nucleic acid for the base sequence. (iit.it)
  • Here, we describe a micelleplex system based on an amphiphilic and cationic triblock copolymer, which can systemically deliver siRNA targeting the acid ceramidase (AC) gene for cancer therapy. (naver.com)
  • Acid Ceramidase Treatment Enhances the Outcome of Autologous Chondrocyte Implantation in a Rat Osteochondral Defect Model. (exponent.com)