Anhydrides: Chemical compounds derived from acids by the elimination of a molecule of water.Phthalic Anhydrides: Phthalic acid anhydrides. Can be substituted on any carbon atom. Used extensively in industry and as a reagent in the acylation of amino- and hydroxyl groups.Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.Acid Anhydride Hydrolases: A group of enzymes that catalyze the hydrolysis of diphosphate bonds in compounds such as nucleoside di- and tri-phosphates, and sulfonyl-containing anhydrides such as adenylylsulfate. (Enzyme Nomenclature, 1992) EC 3.6.Succinic Anhydrides: A subclass of anhydrides with the general structure of dihydrofurandione. They can be substituted on any carbon atom. They modify and inhibit proteins and enzymes and are used in the acylation of amino- and hydroxyl groups.Acetic Anhydrides: Compounds used extensively as acetylation, oxidation and dehydrating agents and in the modification of proteins and enzymes.Aconitic AcidHydrolases: Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.Respiration Disorders: Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.Citraconic Anhydrides: Methylmaleic anhydrides.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Occupational Diseases: Diseases caused by factors involved in one's employment.Glycoside HydrolasesFatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Systems Integration: The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Dinucleoside Phosphates: A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.Adenine NucleotidesNucleoside-Phosphate Kinase: An enzyme that catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside monophosphate, e.g., UMP, to form ADP and UDP. Many nucleoside monophosphates can act as acceptor while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC 2.7.4.4.Phosphoric Monoester Hydrolases: A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of one mole of orthophosphate. EC 3.1.3.Cytidine Monophosphate: Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)CHARGE Syndrome: Rare disease characterized by COLOBOMA; CHOANAL ATRESIA; and abnormal SEMICIRCULAR CANALS. Mutations in CHD7 protein resulting in disturbed neural crest development are associated with CHARGE Syndrome.DNA Helicases: Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.Mi-2 Nucleosome Remodeling and Deacetylase Complex: A enzyme complex involved in the remodeling of NUCLEOSOMES. The complex is comprised of at least seven subunits and includes both histone deacetylase and ATPase activities.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Canidae: A family of terrestrial carnivores with long snouts and non-retractable claws. Members include COYOTES; DOGS; FOXES; JACKALS; RACCOON DOGS; and WOLVES.Pyrophosphatases: A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.Bronchopneumonia: Inflammation of the lung parenchyma that is associated with BRONCHITIS, usually involving lobular areas from TERMINAL BRONCHIOLES to the PULMONARY ALVEOLI. The affected areas become filled with exudate that forms consolidated patches.Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Meristem: A group of plant cells that are capable of dividing infinitely and whose main function is the production of new growth at the growing tip of a root or stem. (From Concise Dictionary of Biology, 1990)Vitis: A plant genus in the family VITACEAE, order Rhamnales, subclass Rosidae. It is a woody vine cultivated worldwide. It is best known for grapes, the edible fruit and used to make WINE and raisins.Plant Shoots: New immature growth of a plant including stem, leaves, tips of branches, and SEEDLINGS.Hepatitis, Infectious Canine: A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.Plant Roots: The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)Malus: A plant genus in the family ROSACEAE, order Rosales, subclass Rosidae. It is best known as a source of the edible fruit (apple) and is cultivated in temperate climates worldwide.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Urogenital Abnormalities: Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.cdc42 GTP-Binding Protein: A member of the Rho family of MONOMERIC GTP-BINDING PROTEINS. It is associated with a diverse array of cellular functions including cytoskeletal changes, filopodia formation and transport through the GOLGI APPARATUS. This enzyme was formerly listed as EC 3.6.1.47.Hand Deformities, Congenital: Alterations or deviations from normal shape or size which result in a disfigurement of the hand occurring at or before birth.Guanine Nucleotide Exchange Factors: Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.GTP-Binding Proteins: Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Bence Jones Protein: An abnormal protein with unusual thermosolubility characteristics that is found in the urine of patients with MULTIPLE MYELOMA.

A novel interaction mechanism accounting for different acylphosphatase effects on cardiac and fast twitch skeletal muscle sarcoplasmic reticulum calcium pumps. (1/700)

In cardiac and skeletal muscle Ca2+ translocation from cytoplasm into sarcoplasmic reticulum (SR) is accomplished by different Ca2+-ATPases whose functioning involves the formation and decomposition of an acylphosphorylated phosphoenzyme intermediate (EP). In this study we found that acylphosphatase, an enzyme well represented in muscular tissues and which actively hydrolyzes EP, had different effects on heart (SERCA2a) and fast twitch skeletal muscle SR Ca2+-ATPase (SERCA1). With physiological acylphosphatase concentrations SERCA2a exhibited a parallel increase in the rates of both ATP hydrolysis and Ca2+ transport; in contrast, SERCA1 appeared to be uncoupled since the stimulation of ATP hydrolysis matched an inhibition of Ca2+ pump. These different effects probably depend on phospholamban, which is associated with SERCA2a but not SERCA1. Consistent with this view, the present study suggests that acylphosphatase-induced stimulation of SERCA2a, in addition to an enhanced EP hydrolysis, may be due to a displacement of phospholamban, thus to a removal of its inhibitory effect.  (+info)

Characterization of the nucleoside triphosphatase activity of poliovirus protein 2C reveals a mechanism by which guanidine inhibits poliovirus replication. (2/700)

The highly conserved non-structural protein 2C of picornaviruses is involved in viral genome replication and encapsidation and in the rearrangement of intracellular structures. 2C binds RNA, has nucleoside triphosphatase activity, and shares three motifs with superfamily III helicases. Motifs "A" and "B" are involved in nucleotide triphosphate (NTP) binding and hydrolysis, whereas a function for motif "C" has not yet been demonstrated. Poliovirus RNA replication is inhibited by millimolar concentrations of guanidine hydrochloride (GdnHCl). Resistance and dependence to GdnHCl map to 2C. To characterize the nucleoside triphosphatase activity of 2C, we purified poliovirus recombinant 2C fused to glutathione S-transferase (GST-2C) from Escherichia coli. GST-2C hydrolyzed ATP with a Km of 0.7 mM. Other NTPs, including GTP, competed with ATP for binding to 2C but were poor substrates for hydrolysis. Mutation of conserved residues in motif A and B abolished ATPase activity, as did mutation of the conserved asparagine residue in motif C, an observation indicating the involvement of this motif in ATP hydrolysis. GdnHCl at millimolar concentrations inhibited ATP hydrolysis. Mutations in 2C that confer poliovirus resistant to or dependent on GdnHCl increased the tolerance to GdnHCl up to 100-fold.  (+info)

The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. (3/700)

NS3 protein of dengue virus type 2 has a serine protease domain within the N-terminal 180 residues. NS2B is required for NS3 to form an active protease involved in processing of the viral polyprotein precursor. The region carboxy terminal to the protease domain has conserved motifs present in several viral RNA-stimulated nucleoside triphosphatase (NTPase)/RNA helicases. To define the functional domains of protease and NTPase/RNA helicase activities of NS3, full-length and amino-terminal deletion mutants of NS3 were expressed in Escherichia coli and purified. Deletion of 160 N-terminal residues of NS3 (as in NS3del.2) had no detrimental effect on the basal and RNA-stimulated NTPase as well as RNA helicase activities. However, mutagenesis of the conserved P-loop motif of the RNA helicase domain (K199E) resulted in loss of ATPase activity. The RNA-stimulated NTPase activity was significantly affected by deletion of 20 amino acid residues from the N terminus or by substitutions of the cluster of basic residues, 184RKRK-->QNGN, of NS3del.2, although both mutant proteins retained the conserved RNA helicase motifs. Furthermore, the minimal NS3 protease domain, required for cleavage of the 2B-3 site, was precisely defined to be 167 residues, using the in vitro processing of NS2B-NS3 precursors. Our results reveal that the functional domains required for serine protease and RNA-stimulated NTPase activities map within the region between amino acid residues 160 and 180 of NS3 protein and that a novel motif, the cluster of basic residues 184RKRK, plays an important role for the RNA-stimulated NTPase activity.  (+info)

The Saccharomyces cerevisiae YOR163w gene encodes a diadenosine 5', 5"'-P1,P6-hexaphosphate (Ap6A) hydrolase member of the MutT motif (Nudix hydrolase) family. (4/700)

The YOR163w open reading frame on chromosome XV of the Saccharomyces cerevisiae genome encodes a member of the MutT motif (nudix hydrolase) family of enzymes of Mr 21,443. By cloning and expressing this gene in Escherichia coli and S. cerevisiae, we have shown the product to be a (di)adenosine polyphosphate hydrolase with a previously undescribed substrate specificity. Diadenosine 5',5"'-P1, P6-hexaphosphate is the preferred substrate, and hydrolysis in H218O shows that ADP and adenosine 5'-tetraphosphate are produced by attack at Pbeta and AMP and adenosine 5'-pentaphosphate are produced by attack at Palpha with a Km of 56 microM and kcat of 0.4 s-1. Diadenosine 5',5"'-P1,P5-pentaphosphate, adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5"'-P1,P4-tetraphosphate or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. The enzyme, which was shown to be expressed in log phase yeast cells by immunoblotting, displays optimal activity at pH 6.9, 50 degrees C, and 4-10 mM Mg2+ (or 200 microM Mn2+). It has an absolute requirement for a reducing agent, such as dithiothreitol (1 mM), and is inhibited by Ca2+ with an IC50 of 3.3 mM and F- (noncompetitively) with a Ki of 80 microM. Its function may be to eliminate potentially toxic dinucleoside polyphosphates during sporulation.  (+info)

Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein. (5/700)

The non-structural protein 3 (NS3) of hepatitis C virus (HCV) possesses three activities which are likely to be essential for virus replication; a serine protease located in the N terminus and helicase and NTPase activities located in the C terminus. Sequence analysis of the helicase/NTPase domain has identified motifs indicative of the DEAD-box family of helicases. Here we present the characterization of the helicase and NTPase activities of full-length NS3, expressed as a His-tagged fusion protein in E. coli, and make comparisons with published data of NS3 helicase domain alone. The helicase and NTPase activities of full-length NS3 have been demonstrated and we have characterized the effects of amino acid substitutions on conserved motifs of NS3 helicase. Helicase and NTPase activities were dependent on Mg2+ and ATP and inhibited by monovalent cations. NS3 was able to hydrolyse all four NTPs and dNTPs to drive DNA duplex unwinding but with differing abilities. NTPase activity was stimulated by all polynucleotides tested, with poly(U) having the greatest effect. Mutational analysis of conserved motifs of NS3 helicase showed all conserved residues to be required for optimal activity. These results are in accord with a recently proposed model for NS3 helicase activity.  (+info)

The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers. (6/700)

We examined 2 normal pancreata, 21 primary pancreatic ductal cancers, and 19 pancreatic cancer cell lines for Fhit expression and FHIT gene status. The normal pancreas expressed Fhit protein in the cytoplasm of ductular cells, whereas interlobular and larger ducts, acini, and insulae of Langerhans were negative. Fhit protein was detected by immunoblot assay in 11 pancreatic cancer cell lines; of the 8 cell lines lacking Fhit protein, 7 lacked FHIT mRNA and 1 showed an abnormally sized transcript. DNA from five of these eight cell lines showed homozygous loss of FHIT exon 5. In 8 of the 21 primary cancers, Fhit expression was detected by immunohistochemistry. Reverse transcription-PCR analysis of 6 of the 13 cases lacking Fhit showed normal-sized FHIT product in 3 cases and a mixture of normal and abnormal products in the other 3. Sequencing showed that abnormal bands were missing variable numbers of exons. Loss of microsatellite DNA markers internal to the FHIT gene was observed in 10 of 13 primary cancers lacking Fhit protein (homozygous in two cases) and in only 1 of the 8 cancers expressing Fhit protein. In nine primary cancers, four expressing and five lacking Fhit protein, it was possible to obtain pure cancer DNA by microdissection. Three of the five microdissected cases lacking Fhit protein exhibited homozygous deletion of FHIT exon 5. In conclusion, the lack of Fhit protein in pancreatic cancers correlated with absence or alteration of FHIT mRNA and was often associated with FHIT gene anomalies.  (+info)

Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is an early event and is highly localized to the FHIT gene locus. (7/700)

The VHL tumor suppressor gene (TSG) at 3p25-26 is strongly implicated in the pathogenesis of clear cell renal cell carcinoma (cRCC). In addition, 3p14.2 and 3p21 are suspected of harboring additional TSGs in cRCC, with FHIT being a candidate TSG at 3p14.2. We examined 87 microdissected, histologically well-defined cRCCs classified according to tumor-node-metastasis (TNM) stage (stage 1, 23 cases; stage 2, 14 cases; stage 3, 24 cases; stage 4, 26 cases) and Fuhrman grade (grade 1, 24 cases; grade 2, 19 cases; grade 3, 19 cases; grade 4, 8 cases; sarcomatoid cRCC, 17 cases) for loss of heterozygosity (LOH) at 3p14.2 and 3p25-26 using a series of precisely mapped microsatellite probes. We found that LOH at 3p14.2 exceeded LOH at 3p25-26 in frequency (69% versus 48.3%; P < 0.03) and was highly localized to markers within the FHIT gene locus (D3S1300 and D3S4260), with the majority of chromosomal breakpoints also mapping to this region. In addition, 3p14.2 LOH (P < 0.03), but not 3p25-26 LOH (P = nonsignificant), was associated with lower tumor grades (grades 1-3). These findings suggest that 3p14.2 genomic deletions may be among the earliest events in cRCC pathogenesis, preceding genomic deletions at the VHL locus. FHIT, or an as yet undiscovered TSG mapping to the D3S4103-D3S4260 interval, could be the molecular target of the 3p14.2 deletions.  (+info)

Designing conditions for in vitro formation of amyloid protofilaments and fibrils. (8/700)

We have been able to convert a small alpha/beta protein, acylphosphatase, from its soluble and native form into insoluble amyloid fibrils of the type observed in a range of pathological conditions. This was achieved by allowing slow growth in a solution containing moderate concentrations of trifluoroethanol. When analyzed with electron microscopy, the protein aggregate present in the sample after long incubation times consisted of extended, unbranched filaments of 30-50 A in width that assemble subsequently into higher order structures. This fibrillar material possesses extensive beta-sheet structure as revealed by far-UV CD and IR spectroscopy. Furthermore, the fibrils exhibit Congo red birefringence, increased fluorescence with thioflavine T and cause a red-shift of the Congo red absorption spectrum. All of these characteristics are typical of amyloid fibrils. The results indicate that formation of amyloid occurs when the native fold of a protein is destabilized under conditions in which noncovalent interactions, and in particular hydrogen bonding, within the polypeptide chain remain favorable. We suggest that amyloid formation is not restricted to a small number of protein sequences but is a property common to many, if not all, natural polypeptide chains under appropriate conditions.  (+info)

Looking for online definition of diphosphoinositol polyphosphate phosphohydrolase 3-beta in the Medical Dictionary? diphosphoinositol polyphosphate phosphohydrolase 3-beta explanation free. What is diphosphoinositol polyphosphate phosphohydrolase 3-beta? Meaning of diphosphoinositol polyphosphate phosphohydrolase 3-beta medical term. What does diphosphoinositol polyphosphate phosphohydrolase 3-beta mean?
The human fragile histidine triad (FHIT) gene encodes a protein that is involved in purine metabolism. Aberrant transcripts from this gene, typically from carcinogen-induced damage and translocations, have been found in about half of all esophageal, stomach, and colon carcinomas. Although the exact function of human FHIT protein is not known, animal studies have demonstrated its role as a tumor suppressor in breast and lung cancers. FHIT protein is also known as bis(5-adenosyl)-triphosphatase, diadenosine 5,5-P1,P3-triphosphate hydrolase, AP3A hydrolase, AP3Aase, dinucleosidetriphosphatase, and FRA3B.. ...
The human fragile histidine triad (FHIT) gene encodes a protein that is involved in purine metabolism. Aberrant transcripts from this gene, typically from carcinogen-induced damage and translocations, have been found in about half of all esophageal, stomach, and colon carcinomas. Although the exact function of human FHIT protein is not known, animal studies have demonstrated its role as a tumor suppressor in breast and lung cancers. FHIT protein is also known as bis(5-adenosyl)-triphosphatase, diadenosine 5,5-P1,P3-triphosphate hydrolase, AP3A hydrolase, AP3Aase, dinucleosidetriphosphatase, and FRA3B.. ...
We have shown: (a) that adenoviral vector-mediated overexpression of the wild-type FHIT gene efficiently inhibited growth of tumor cells of varying FHIT gene and gene product status in vitro; (b) that the tumorigenicity of the Ad-FHIT-transduced tumor cells was eliminated in vivo; and (c) that tumor growth was significantly suppressed by direct injection of the FHIT-expressing adenoviral vector into s.c. tumors in nude mice. These results provided direct evidence for the biological function of FHIT as a tumor suppressor gene both in vitro and in vivo.. The lung cancer cell lines H1299, A549, and H460 and the head and neck carcinoma cell line 1483 all exhibit an altered or inactivated FHIT gene, as shown by reverse transcription-PCR and Northern blot analysis (7 , 9 , 18) , lack endogenous Fhit protein expression, as shown by Western blot analysis, and are highly tumorigenic. Alterations in the FHIT locus have been shown to be correlated with loss or reduction of Fhit protein expression in tumors ...
In this study, we have demonstrated that 44% of colorectal cancers have markedly reduced expression of Fhit protein. A similar reduction of Fhit protein expression has been reported in other human tumors such as lung (4) , cervical (12) , renal (11) , pancreatic (10) , head and neck (6) , and breast (5) carcinomas. The frequent loss of Fhit protein expression, the expression of aberrant FHIT transcripts, and numerous deletions within the FHIT gene suggest that FHIT is a candidate suppressor gene common to many cancers (reviewed in Ref. 1 ). In addition to the loss of Fhit protein expression, our studies found additional evidence that suggests that Fhit is important in colon tumorigenesis. A trend of increased proportions of colorectal cancers expressed reduced levels of Fhit (a) with decreasing degrees of differentiation, (b) with more advanced stages (Dukes stage C and D) compared with less advanced stages (Dukes stage A and B) of primary tumors, and (c) in metastatic lesions compared with ...
Definition of fragile histidine triad. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control ...
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control ...
Accepted name: diphosphoinositol-polyphosphate diphosphatase. Reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. Other name(s): diphosphoinositol-polyphosphate phosphohydrolase; DIPP. Systematic name: diphospho-myo-inositol-polyphosphate diphosphohydrolase. Comments: This enzyme hydrolyses the diphosphate bond, leaving a phospho group where a diphospho group had been. It can also act on bis(adenosine) diphosphate.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: References:. 1. Safrany, S.T., Caffrey, J.J., Yang, X., Bembenek, M.E., Moyer, M.B., Burkhart, W.A. and Shears, S.B. A novel context for the MutT module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. EMBO J. 17 (1998) 6599-6607. [PMID: 9822604]. 2. Caffrey, J.J., Safrany, S.T., Yang, X. and Shears, S.B. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An ...
1FHI: Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Buy our Recombinant Human FHIT protein. Ab95856 is a full length protein produced in Escherichia coli and has been validated in SDS-PAGE, MS. Abcam provides…
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RNA triphosphatase is an essential mRNA processing enzyme that catalyzes the first step in cap formation. The 2.05 A crystal structure of yeast RNA triphosphatase Cet1p reveals a novel active site fold whereby an eight-stranded beta barrel forms a topologically closed triphosphate tunnel. Interactions of a sulfate in the center of the tunnel with a divalent cation and basic amino acids projecting into the tunnel suggest a catalytic mechanism that is supported by mutational data. Discrete surface domains mediate Cet1p homodimerization and Cet1p binding to the guanylyltransferase component of the capping apparatus. The structure and mechanism of fungal RNA triphosphatases are completely different from those of mammalian mRNA capping enzymes. Hence, RNA triphosphatase presents an ideal target for structure-based antifungal drug discovery ...
Addition of acylphosphatase exerted a stimulating effect on the alcoholic fermentation of glucose by Saccharomyces cerevisiae. The rates of glucose degradation and ethanol production by cell-free extracts of the S-288C strain were measured in the absence and in the presence of various levels of this enzyme. Two acylphosphatase isoenzymes were used; one was purified from horse skeletal muscle and the other from human erythrocytes. Both increased the rate of alcoholic fermentation, but that from erythrocytes proved to be the more efficient. This stimulating action is probably due to an uncoupling effect of acylphosphatase on the fermentative process, through hydrolysis of 3-phosphoglyceroyl phosphate. This was demonstrated by the fact that alcoholic fermentation was stimulated considerably by a mixture of ADP and inorganic phosphate and by arsenate as well. The possibility of improving the fermentative capacity of microorganisms may have important biotechnological applications.. ...
bis(5-nucleosyl)tetraphosphatase (asymmetrical): forms a nucleoside triphosphate plus a nucleoside monophosphate; for symmetrical cleavage, see bis(5-nucleosyl)tetraphosphatase (symmetrical)
Nit Protein; One Of Two Proteins In S. Cerevisiae With Similarity To The Nit Domain Of NitFhit From Fly And Worm And To The Mouse And Human Nit Protein Which Interacts With The Fhit Tumor Suppressor; Nitrilase Superfamily Member
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从昨天开始,四六级阅卷已经开始了 这两天主要是改短文和复合,可以说,短文的正确率很低很低 由于阅卷太累,具体得分情况注意今后我的帖子
TY - JOUR. T1 - Deletion of the FHIT gene in neoplastic and invasive cervical lesions is related to high-risk HPV infection but is independent of histopathological features. AU - Butler, David. AU - Collins, Claire. AU - Mabruk, Mohamed. AU - Walsh, Caitriona Barry. AU - Leader, Mary B.. AU - Kay, Elaine W.. PY - 2000. Y1 - 2000. N2 - The fragile histidine triad (FHIT) gene encompasses the common chromosomal fragile site FRA3B. Human papilloma virus (HPV), which is the main aetiological agent in cervical cancers, has been found to be able to integrate its genes into the chromosome 3 fragile site of cultured cells, deleting a piece of DNA which includes the FHIT gene. Eighty-six microdissected archival cervical LLETZ biopsies comprising cases of cervical intraepithelial neoplasia (CIN) I (n=27), CIN3 (n=30) and microinvasive carcinoma (n=29) were evaluated for HPV infection and FHIT gene loss of heterozygosity (LOH). FHIT gene LOH was detected by polymerase chain reaction (PCR) using ...
Purified fractions of cytosol, vacuoles, nuclei, and mitochondria of Saccharomyces cerevisiae possessed inorganic polyphosphates with chain lengths characteristic of each individual compartment. The most part (80-90%) of the total polyphosphate level was found in the cytosol fractions. Inactivation of a PPX1 gene encoding ∼40-kDa exopolyphosphatase substantially decreased exopolyphosphatase activities only in the cytosol and soluble mitochondrial fraction, the compartments where PPX1 activity was localized. This inactivation slightly increased the levels of polyphosphates in the cytosol and vacuoles and had no effect on polyphosphate chain lengths in all compartments. Exopolyphosphatase activities in all yeast compartments under study critically depended on the PPN1 gene encoding an endopolyphosphatase. In the single PPN1 mutant, a considerable decrease of exopolyphosphatase activity was observed in all the compartments under study. Inactivation of PPN1 decreased the polyphosphate level in the ...
Diadenosine triphosphate is present in platelet-dense granules and released quantitatively on platelet aggregation. We have found that intact porcine aortic endothelial cells can efficiently hydrolyze extracellular diadenosine triphosphate. The products of diadenosine triphosphate hydrolysis are adenosine monophosphate and adenosine diphosphate. Adenosine diphosphate is a potent stimulus of platelet aggregation. Since platelet-dense granules contain high concentrations of adenosine triphosphate and adenosine diphosphate, we examined endothelial cell hydrolysis of a mixture of diadenosine triphosphate and adenosine triphosphate. We find that the presence of adenosine triphosphate severely inhibits the hydrolysis of diadenosine triphosphate. Thus, although endothelial cells can rapidly clear extracellular diadenosine triphosphate, during platelet aggregation the hydrolysis of diadenosine triphosphate may be slow due to the presence of high concentrations of other adenine nucleotides. This ...
Aberrant Fhit expression characterizes a large proportion of primary pancreatic ductal adenocarcinomas (PDACs), but fragmentary information is available on Fhit expression during the phenotypic changes of pancreatic ductal epithelium during multistep transformation. We assessed Fhit expression by immunohistochemistry in two different multistep pancreatic carcinogenic processes: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). We considered 105 surgically treated PDACs/IPMNs and selected 30 samples of non-neoplastic pancreatic parenchyma, 50 PanIN lesions, 30 IPMNs, 15 IPMNs with associated invasive carcinoma, and 60 adenocarcinomas. Normal pancreatic ducts and surrounding acinar cells consistently showed moderate to strong Fhit immunoreactivity. Significant down-regulation of Fhit expression was observed in association with increasing severity of dysplastia/neoplastia in both carcinogenic processes. This was further confirmed by studying multiple ...
The Structure of the Exopolyphosphatase (PPX) from Escherichia coli O157:H7 Suggests a Binding Mode for Long Polyphosphate Chains
Propranolol hydroxyzine interactions and associates evaluated specimens from six patients and found inactivation of the FHIT tumor suppressor with microsatellite instability in one specimen; in the remaining five cases, neither FHIT nor microsatellite instability was found. W.
NTPase activity of CHIKV-nsP2T.Effect of poly (U) RNA on ATPase activity: CHIKV-nsP2T protein was incubated in a 50 µl reaction containing 50 mM MOPS at pH 7.2
Back on Track pads are used by many Top Riders all over the World and they see remarkable differences in their horses movements. They can help accelerate the recovery rate from strenuous exercise.
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Mouse monoclonal antibody raised against a partial recombinant FHIT. FHIT (AAH32336, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00002272-M05) - Products - Abnova
Effect of different conditions on the RNA 5′-triphosphatase activity of CHIKV-nsP2T.Effect of AMP, ADP and ATP on RTPase activity: CHIKV-nsP2T was incubated w
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Tečaj iz kriptografije in seminar iz kriptografije - podiplomski študij matematike (cet. 8-10) in IMFM (cet. 14-16), Jadranska 19 (III/PS), LJ ...
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The physiological roles of polyphosphates (polyP) recently found in arthropod mitochondria remain obscure. Here, the relationship between the mitochondrial membrane exopolyphosphatase (PPX) and the energy metabolism of hard tick Rhipicephalus microplus embryos are investigated. Mitochondrial respiration was activated by adenosine diphosphate using polyP as the only source of inorganic phosphate (Pi) and this activation was much greater using polyP3 than polyP15. After mitochondrial subfractionation, most of the PPX activity was recovered in the membrane fraction and its kinetic analysis revealed that the affinity for polyP3 was 10 times stronger than that for polyP15. Membrane PPX activity was also increased in the presence of the respiratory substrate pyruvic acid and after addition of the protonophore carbonyl cyanide-p-trifluoromethoxyphenylhydrazone. Furthermore, these stimulatory effects disappeared upon addition of the cytochrome oxidase inhibitor potassium cyanide and the activity was completely
Diadenosine tetraphosphate or Ap4A is a putative alarmone, ubiquitous in nature being common to everything from bacteria to humans. Adenosine polyphosphates are capable of inducing multiple physiological effects. The molecules role as a second messenger has recently been discovered in The LysRS-Ap4A-MITF signaling pathway. *Luo J, Jankowski V, Güngär N, Neumann J, Schmitz W, Zidek W, Schlüter H, Jankowski J (2004). "Endogenous diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate in human myocardial tissue". Hypertension. 43 (5): 1055-9. doi:10.1161/01.hyp.0000126110.46402.dd. PMID 15066958. *Lee YN, Nechushtan H, Figov N, Razin E (April 2004). "The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells". Immunity. 20 (2): 145-51. doi:10.1016/S1074-7613(04)00020-2. PMID 14975237 ...
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The histidine triad (Strike) protein Hint continues to be found to associate with mammalian Cdk7 aswell concerning interact both physically and genetically using the budding yeast Cdk7 homologue Kin28. 32 Aprataxin was discovered through mapping from the gene in charge of ataxia-ocular apraxia in human beings (6 21 To time Hint is not associated with individual disease. Strike hydrolases hydrolyze uncommon adenosine nucleotides. This activity is certainly well characterized for Fhit Foretinib and its own budding fungus orthologue Hnt2 that are both diadenosine triphosphate (Ap3A) asymmetric hydrolases in vitro (1 4 17 and in vivo (5 22 28 The natural need for the hydrolase activity of Fhit/Hnt2 continues to be to become characterized as null fungus does not have any detectable phenotype (aside from the accumulation from the Ap3A substrate) and Fhit hydrolase activity amazingly will not correlate using its tumor suppressor function (29 30 Hint also possesses in vitro affinity (10) and hydrolase ...
The fragile gene, encompassing the chromosomal fragile site FRA3B, can be an early target of DNA damage in precancerous cells. can occur in regular lead and cells to regions of metaplasia with minimal FHIT expression. Loss of the next allele can result in complete lack of FHIT manifestation, which can be seen in many dysplastic Read More. ...
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Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5- monophosphates and ribonucleoside 3-monophosphates with highest affinity to 3-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth ...
Horses have a much higher ratio of muscle than humans, meaning their bodies generate more heat in less time. Horse muscle makes up around 40% of a horses body
Adenosine triphosphate, labeled on the gamma phosphate group with 32P. For applications such as DNA and RMA labeling, T4 PNK labeling, and kinase assays.
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TY - JOUR. T1 - MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. AU - Yamaguchi, H.. AU - Kajitani, K.. AU - Dan, Y.. AU - Furuichi, M.. AU - Ohno, M.. AU - Sakumi, K.. AU - Kang, D.. AU - Nakabeppu, Yusaku. PY - 2006/4/1. Y1 - 2006/4/1. N2 - We previously reported that 8-oxoguanine (8-oxoG) accumulates in the cytoplasm of dopamine neurons in the substantia nigra of patients with Parkinsons disease and the expression of MTH1 carrying an oxidized purine nucleoside triphosphatase activity increases in these neurons, thus suggesting that oxidative damage in nucleic acids is involved in dopamine neuron loss. In the present study, we found that levels of 8-oxoG in cellular DNA and RNA increased in the mouse nigrostriatal system during the tyrosine hydroxylase (TH)-positive dopamine neuron loss induced by the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ...
Clin Microbiol Infect Pneumococcal surface proteins (PSPs) elicit antibody responses in infants and young children exposed to Streptococcus pneumoniae. These seroresponses could contribute to the aetiological diagnosis of pneumococcal disease, e.g. during the clinical development of novel PSP-based vaccines. In this study, we assessed the kinetics of antibody responses to three highly conserved and immunogenic PSPs (pneumococcal histidine triad D (PhtD), pneumococcal choline-binding protein A (PcpA), and serine proteinase precursor A (PrtA)) in 106 children (median age, 21.3 months; males, 58.5%) admitted for pneumococcal bacteraemia. Anti-PhtD, anti-PcpA and anti-PrtA antibodies were measured by ELISA, and compared in 61 pairs of acute (≤7 days) and convalescent (>14 days of admission) serum samples. Acute serum titres were similar to those observed in healthy children, and were unaffected by the acid dissociation of circulating immune complexes. Despite proven bacteraemia, seroresponses ...
1b) a nucleoside 5-diphosphate + H2O = a nucleoside 5-phosphate + phosphate. Other name(s): ATP-diphosphatase; adenosine diphosphatase; ADPase; ATP diphosphohydrolase [ambiguous]. Systematic name: nucleoside triphosphate phosphohydrolase (nucleoside monophosphoate-forming). Comments: Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyse NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. They differ from ATPases, which specifically hydrolyse ATP, by hydrolysing both ATP and ADP. The eukaryotic enzymes requires Ca2+, but Mg2+ can substitute. Most of the ecto-ATPases that occur on the cell surface and hydrolyse extracellular nucleotides belong to this enzyme family.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9000-95-7. References:. 1. Krishnan, P.S. Apyrase, pyrophosphatase and metaphosphatase of Penicillium chrysogenum. Arch. Biochem. Biophys. 37 ...
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Inorganic polyphosphate (polyP) is found in all living organisms. The known polyP functions in eukaryotes range from osmoregulation and virulence in parasitic protozoa to modulating blood coagulation, inflammation, bone mineralization and cellular signalling in mammals. However mechanisms of regulation and even the identity of involved proteins in many cases remain obscure. Most of the insights obtained so far stem from studies in the yeast Saccharomyces cerevisiae. Here, we provide a short overview of the properties and functions of known yeast polyP metabolism enzymes and discuss future directions for polyP research. ...
Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5monophosphoramidate (AMP-NH2), adenosine 5monophosphomorpholidate (AMP-morpholidate) and guanosine 5monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. May also function as scaffolding protein that mediates protein-protein interactions (By similarity).
Diadenosine 5′,5‴-P1,P3-triphosphate (Ap3A) and diadenosine 5′,5‴-P1,P4-tetraphosphate (Ap4A) induce distinctive patterns of [Ca2+]i oscillations in single rat hepatocytes. We show here that [Ca2+]i oscillations induced by Ap3A and ADP are indistinguishable and that [Ca2+]i oscillations induced by Ap4A closely resemble those induced by ATP. These similarities embrace the following: (1) ADP and Ap3A invariably induce [Ca2+]i transients of short duration (approx. 9 s). Ap4A, like ATP, can induce, depending upon the individual cell, either transients of short duration (approx. 9 s), transients of much longer duration or a mixture of short and long transients within a single response. We show here that the pattern of oscillations induced by Ap4A is similar to that induced by ATP in the same hepatocyte. (2) Elevated intracellular cyclic AMP concentration modulates Ap3A-induced transients, like ADP-induced transients, through an increase in both the peak [Ca2+]i and the frequency of the ...
Prashanti Patil, University of Pittsburgh. S4.3: Older Mice Exposed to Young Systemic Environments Have Healthier Discs. 2nd Place. Rahul Gawri, MD, PhD, University of Toronto. S3.14: Role of Inorganic Polyphosphates in Enhancing Nucleus Pulposus Tissue Formation In Vitro. PSRS Poster Award Recipients. Pathobiology Mechanisms and Pain. 1st Place ...
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Inorganic polyphosphate (poly P) is a chain of tens or many hundreds of phosphate (Pi) residues linked by high-energy phosphoanhydride bonds. Despite inorganic polyphosphates ubiquity--found in every cell in nature and likely conserved from prebiotic times--this polymer has been given scant attention. Among the reasons for this neglect of poly P have been the lack of sensitive, definitive, and facile analytical methods to assess its concentration in biological sources and the consequent lack of demonstrably important physiological functions. This review focuses on recent advances made possible by the introduction of novel, enzymatically based assays. The isolation and ready availability of Escherichia coli polyphosphate kinase (PPK) that can convert poly P and ADP to ATP and of a yeast exopolyphosphatase that can hydrolyze poly P to Pi, provide highly specific, sensitive, and facile assays adaptable to a high-throughput format. Beyond the reagents afforded by the use of these enzymes, their ...
Inorganic polyphosphate (poly P) is a chain of tens or many hundreds of phosphate (Pi) residues linked by high-energy phosphoanhydride bonds. Despite inorganic polyphosphates ubiquity--found in every cell in nature and likely conserved from prebiotic times--this polymer has been given scant attention. Among the reasons for this neglect of poly P have been the lack of sensitive, definitive, and facile analytical methods to assess its concentration in biological sources and the consequent lack of demonstrably important physiological functions. This review focuses on recent advances made possible by the introduction of novel, enzymatically based assays. The isolation and ready availability of Escherichia coli polyphosphate kinase (PPK) that can convert poly P and ADP to ATP and of a yeast exopolyphosphatase that can hydrolyze poly P to Pi, provide highly specific, sensitive, and facile assays adaptable to a high-throughput format. Beyond the reagents afforded by the use of these enzymes, their ...
Inorganic polyphosphate (poly P) is a chain of tens or many hundreds of phosphate (Pi) residues linked by high-energy phosphoanhydride bonds. Despite inorganic polyphosphates ubiquity--found in every cell in nature and likely conserved from prebiotic times--this polymer has been given scant attention. Among the reasons for this neglect of poly P have been the lack of sensitive, definitive, and facile analytical methods to assess its concentration in biological sources and the consequent lack of demonstrably important physiological functions. This review focuses on recent advances made possible by the introduction of novel, enzymatically based assays. The isolation and ready availability of Escherichia coli polyphosphate kinase (PPK) that can convert poly P and ADP to ATP and of a yeast exopolyphosphatase that can hydrolyze poly P to Pi, provide highly specific, sensitive, and facile assays adaptable to a high-throughput format. Beyond the reagents afforded by the use of these enzymes, their ...
article{31e5f1bd-a4e6-4a4d-9882-e8e6db59f82f, abstract = {Glucose-evoked insulin secretion exhibits a biphasic time course and is associated with accelerated intracellular granule movement. We combined live confocal imaging of EGFP-labelled insulin granules with capacitance measurements of exocytosis in clonal INS-1 cells to explore the relation between distinct random and directed modes of insulin granule movement, as well as exocytotic capacity. Reducing the temperature from 34 °C to 24 °C caused a dramatic 81% drop in the frequency of directed events, but reduced directed velocities by a mere 25%. The much stronger temperature sensitivity of the frequency of directed events (estimated energy of activation ~ 135 kJ/mol) than that of the granule velocities (~ 22 kJ/mol) suggests that cooling-induced suppression of insulin granule movement is attributable to factors other than reduced motor protein adenosine 5-triphosphatase activity. Indeed, cooling suppresses random granule diffusion by ~ ...
Research Summary: The report presents detailed overview of the Sodium Tripolyphosphate market in the world and regions (CIS countries in particular) by contemplating and analyzing its various parameters. Firstly, brief introduction is provided. Thus, Sodium Tripolyphosphate properties, application areas and manufacturing technologies are considered. Further goes the analysis of global Sodium Tripolyphosphate market with emphasis on its […].... ...
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collaborators are performing a comprehensive study of the Mira AB interacting system, using the WFPC2 camera on the Hubble Space Telescope. Mira AB is composed of the prototype Mira variable omi Cet and its companion VZ Cet, separated by about 0.5 arcsecond. As part of this project they plan to obtain a large number of high-angular resolution images at wavelengths ranging from UV to optical. The main objectives of the HST/WFPC2 observations are: ...
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Indeed, we should make the compiler much more robust by checking invariants on the Parsetree which are assumed and currently enforced by the parser (but not by -pp / -ppx). This is one more instance of it ...
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Vaccine. 2017 May 2;35(19):2531-2542. doi: 10.1016/j.vaccine.2017.03.071. Epub 2017 Apr 4.. Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study.. Odutola A1, Ota MO2, Antonio M3, Ogundare EO4, Saidu Y5, Foster-Nyarko E6, Owiafe PK7, Ceesay F8, Worwui A9, Idoko OT10, Owolabi O11, Bojang A12, Jarju S13, Drammeh I14, Kampmann B15, Greenwood BM16, Alderson M17, Traskine M18, Devos N19, Schoonbroodt S20, Swinnen K21, Verlant V22, Dobbelaere K23, Borys D24.. Author information. Abstract. BACKGROUND:. Conserved pneumococcal proteins are potential candidates for inclusion in vaccines against pneumococcal diseases. In the first part of a two-part study, an investigational vaccine (PHiD-CV/dPly/PhtD-30) containing 10 pneumococcal serotype-specific polysaccharide conjugates (10VT) combined with pneumolysin toxoid and pneumococcal histidine triad protein D (30μg each) was well ...
TY - JOUR. T1 - Chromosomal aberrations and common fragile sites in neuroblastoma patients. AU - Vernole, P.. AU - Tedeschi, B.. AU - Pianca, C.. AU - Nicoletti, B.. AU - Riccardi, R.. AU - Melino, G.. PY - 1990. Y1 - 1990. N2 - We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.. AB - We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin ...
In enzymology, a mRNA guanylyltransferase (EC 2.7.7.50) is an enzyme that catalyzes the chemical reaction GTP + (5)ppPur-mRNA ⇌ {\displaystyle \rightleftharpoons } diphosphate + G(5)pppPur-mRNA Thus, the two substrates of this enzyme are GTP and (5)ppPur-mRNA, whereas its two products are diphosphate and G(5)pppPur-mRNA. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:mRNA guanylyltransferase. Other names in common use include mRNA capping enzyme, messenger RNA guanylyltransferase, and Protein 2. As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1CKM, 1CKN, 1CKO, 1P16, and 2C46. Ensinger MJ, Martin SA, Paoletti E, Moss B (1975). "Modification of the 5-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus". Proc. Natl. Acad. Sci. U.S.A. 72 (7): 2525-9. ...
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Rear End Conformation An Analysis by Lee Ziegler Rear End One Rear End Two Rear End Three While front end conformation determines more how a horse will perform a gait than which gait he will do well, rear end conformation gives a good clue as to which.... ...
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The Escherichia coli mutant (ppk) lacking the enzyme polyphosphate kinase, which makes long chains of inorganic polyphosphate (poly P), is deficient in functions expressed in the stationary phase of growth. After 2 days of growth in a medium limited in carbon sources, only 7% of the mutants survived compared with nearly 100% of the wild type; the loss in viability of the mutant was even more pronounced in a rich medium. The mutant showed a greater sensitivity to heat, to an oxidant (H2O2), to a redox-cycling agent (menadione), and to an osmotic challenge with 2.5 M NaCl. After a week or so in the stationary phase, mutant survivors were far fewer in number and were replaced by an outgrowth of a small-colony-size variant with a stable genotype and with improved viability and resistance to heat and H2O2; neither polyphosphate kinase nor long-chain poly P was restored. Suppression of the ppk feature of heat sensitivity by extra copies of rpoS, the gene encoding the RNA polymerase sigma factor that ...
Comparative in vivo 31P-NMR studies of mycorrhized and nonmycorrhized roots of Fagus sylvatica and Pinus sylvestris and of the fungus Suillus bovinus in pu
TRPA1 can also detect many non-electrophilic phytochemicals and some synthetic compounds, probably in the traditional receptor-ligand binding fashion. These types of ligands, such as δ-9-tetrahydrocannabinol (THC) and icilin, display rapid reversibility. Their responses are tolerant to substitution of critical cysteine residues for the covalent attack, suggesting that traditional ligands use separate TRPA1 binding sites (Hinman et al., 2006; Macpherson et al., 2007a). Unlike RES ligands, THC does not need cofactors such as inorganic polyphosphates to activate TRPA1 (Cavanaugh et al., 2008; see below). Thus, the mechanism that couples binding to gating in noncovalent ligand-evoked TRPA1 activation is likely to be independent of that in covalent ligand-evoked activation. The chemical structures of plant-derived TRPA1 agonists and antagonists are heterogeneous (for example, menthol, eugenol, camphor, THC, citral, etc.). Future expansion of knowledge about natural ligands will be needed to ...
Press Release issued Dec 4, 2017: Market Research Future (MRFR) recognizes the following companies as the key players in the Global Sodium Tripolyphosphate Market: Innophos Holding Inc., Tata Chemicals Ltd., ICL Performance Ltd., Aditya Birla Chemicals, Sumitomo Chemicals Co. Ltd, Merck group, Hubei Xingfa Chemicals Group, Prayon S.A., Haifa Group, and TongVo Chemicals Limited
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1PUS: Solution structure and NH exchange studies of the MutT pyrophosphohydrolase complexed with Mg(2+) and 8-oxo-dGMP, a tightly bound product.
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At the CET Film, CET Photography, and CET New Media programs, students attend classes for about 3 hours/day, with a minimum of 1 hour/day and a maximum of 5 hours/day. Class size ranges from 1 student to 15 students, and […]. ...
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Metode til vurdering af planteoptag fra forurenet jord Modelværktøj Miljøprojekt nr. 1592, 2014 Titel: Metode til vurdering af planteoptag fra forurenet jord Redaktion: Dorte Rasmussen, DHI Stefan Trapp,
Kom hjem i nat efter et par dage i Simrishamn sammen med Jarl som gast og en flok fra JSK. Det blev til tre laks i alt hvoraf en på 4 kg. er kommet i fryseren ...
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Sigdcelleanemi er en blodsykdom som nedarves fra begge foreldrene. Sykdommen er vanligere i visse etniske grupper som afrikanere, arabere, grekere, it...
High-polymeric inorganic polyphosphates were found in living organisms by L. Liberman in 1890. These compounds are linear polymers containing a few to several hundred residues of orthophosphate linked by energy-rich phosphoanhydride bonds. Previously, it was considered either as "molecular fossil" or as only a phosphorus and energy source providing the survival of microorganisms under extreme conditions. These compounds are now known to also have regulatory roles, and to occur in representatives of all kingdoms of living organisms, participating in metabolic correction and control on both genetic and enzymatic levels. Polyphosphate is directly involved in the switching-over of the genetic program characteristic of the exponential growth stage of bacteria to the program of cell survival under stationary conditions, "a life in the slow line". They participate in many regulatory mechanisms occurring in bacteria: ...
... s are acid anhydride hydrolases that act upon diphosphate bonds. Examples include: Inorganic pyrophosphatase ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is triphosphate phosphohydrolase. This enzyme is also called inorganic ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is acylphosphate phosphohydrolase. Other names in common use include ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is diphospho-myo-inositol-polyphosphate diphosphohydrolase. Other names in ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is trimetaphosphate hydrolase. This enzyme is also called inorganic ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase. Other names ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is nucleoside-triphosphate diphosphohydrolase. This enzyme is also called ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... GLASER L (1965). "THE SYNTHESIS OF TEICHOIC ACID. IV. ON THE REGULATION OF CYTIDINE 5'-DIPHOSPHATEGLYCEROL CONCENTRATION". ... anhydrides. The systematic name of this enzyme class is CDP-glycerol phosphoglycerohydrolase. Other names in common use include ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is ADP-sugar sugarphosphohydrolase. Other names in common use include ADP- ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is dTTP nucleotidohydrolase. Other names in common use include thymidine ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase. Other ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is diphosphate phosphohydrolase. This enzyme participates in oxidative ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase. Other names in ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Small GD, Cooper C (1966). "Purification and properties of nucleoside tetraphosphate hydrolase from rabbit muscle". ... anhydrides. The systematic name of this enzyme class is adenosine-tetraphosphate phosphohydrolase. This enzyme participates in ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'- ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Brightwell R, Tappel AL (1968). "Lysosomal acid pyrophosphatase and acid phosphatase". Arch. Biochem. Biophys. 124 (1): 333-43 ... anhydrides. The systematic name of this enzyme class is unspecific diphosphate phosphohydrolase. Other names in common use ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is GDP phosphohydrolase. This enzyme is also called GDPase. Raychaudhuri P ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is oligosaccharide-diphosphodolichol phosphodolichohydrolase. This enzyme ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Glaser L, Melo A, Paul R (1987). "Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor". J. Biol. ... UDP-sugar hydrolase, and UDP-sugar pyrophosphatase. As of late 2007, 6 structures have been solved for this class of enzymes, ... anhydrides. The systematic name of this enzyme class is UDP-sugar sugarphosphohydrolase. Other names in common use include ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Ap4A hydrolase, bis(5'-adenosyl) tetraphosphatase, diadenosine tetraphosphate hydrolase, diadenosine polyphosphate hydrolase, ... anhydrides. The systematic name of this enzyme class is P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase. ... symmetrical diadenosine tetraphosphate hydrolase, adenosine tetraphosphate phosphodiesterase, ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ... "The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces ...
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ... Acid growth. Acidification of the external medium caused by activation of the plasma membrane H+ -ATPase initiates cellular ...
Hydrolases: acid anhydride hydrolases (EC 3.6). 3.6.1. *Pyrophosphatase *Inorganic. *Thiamine. *Apyrase ... Cdc42 is a homodimer with A and B chains.[6] Its total length is 191 amino acids and its theoretical weight is 21.33 KDa.[6] ... Its sequence domains include a P-loop containing nucleoside triphosphate hydrolase and a small GTP-binding protein domain.[6] ...
Acid anhydride hydrolases are a class of hydrolase enzymes that catalyze the hydrolysis of an acid anhydride bond. They are ... 2012). Acid Anhydride Hydrolases: Advances in Research and Application. Acid anhydride hydrolases at the US National Library of ... List of EC numbers (EC 3)#EC 3.6: act on acid anhydrides Ashton Acton, ed. ( ...
... and sulfonyl-containing anhydrides such as adenylylsulfate. (Enzyme Nomenclature, 1992) EC 3.6. ... Acid Anhydride Hydrolases: A group of enzymes that catalyze the hydrolysis of diphosphate bonds in compounds such as nucleoside ... Acid Anhydride Hydrolases. Subscribe to New Research on Acid Anhydride Hydrolases A group of enzymes that catalyze the ... hydrolysis of diphosphate bonds in compounds such as nucleoside di- and tri-phosphates, and sulfonyl-containing anhydrides such ...
"Acid Anhydride Hydrolases" by people in this website by year, and whether "Acid Anhydride Hydrolases" was a major or minor ... "Acid Anhydride Hydrolases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Acid Anhydride Hydrolases*Acid Anhydride Hydrolases. *Anhydride Hydrolases, Acid. *Hydrolases, Acid Anhydride ... Below are the most recent publications written about "Acid Anhydride Hydrolases" by people in Profiles. ...
Acid Anhydride Hydrolases / metabolism * Endoribonucleases / metabolism * Escherichia coli / genetics* * Escherichia coli ...
Acid Anhydride Hydrolases / metabolism * Adult * Biomarkers, Tumor / metabolism* * Cervical Intraepithelial Neoplasia / ...
Classification: HYDROLASE(ACTING ON ACID ANHYDRIDES). *Organism(s): Bos taurus. *Deposited: 1994-05-17 Released: 1994-08-31 ...
GO:0016817 hydrolase activity, acting on acid anhydrides GO:0016887 ATPase activity GO:0042393 histone binding ...
Acid anhydride hydrolases: ATPases (EC 3.6.3-3.6.4). 3.6.3. Cu++ (Menkes, Wilson) - Ca+ (SERCA, Plasma membrane) - Na+/K+ - H+/ ... The gene ATP4B encodes the β subunit of the H+/K+ ATPase, which is an ~ 300 amino acid protein with a 36 amino acid N-terminal ... The gene ATP4A encodes the H+/K+ ATPase α subunit contains and is an ~ 1000 amino acid protein that contains the catalytic ... Inhibiting gastric acid secretion by blocking the activity is a very common clinical intervention used in diseases including ...
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA Inferred from Electronic Annotation. ... P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases. * NM_001166665.1 → NP_001160137.1 regulator of telomere ... P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases. * NM_001166666.1 → NP_001160138.1 regulator of telomere ... P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases. * NM_001166667.1 → NP_001160139.1 regulator of telomere ...
Acid Anhydride Hydrolases [D08.811.277.040]. *GTP Phosphohydrolases [D08.811.277.040.330]. *GTP-Binding Proteins [D08.811. ... Masago K, Kihara Y, Yanagida K, Hamano F, Nakagawa S, Niwa M, Shimizu T. Lysophosphatidic acid receptor, LPA6, regulates ...
Hydrolases [D08.811.277]. *Acid Anhydride Hydrolases [D08.811.277.040]. *Adenosine Triphosphatases [D08.811.277.040.025] ... Greenberg RS, Long HK, Swigut T, Wysocka J. Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human ...
Acid Anhydride Hydrolases [D08.811.277.040]. *GTP Phosphohydrolases [D08.811.277.040.330]. *GTP-Binding Proteins [D08.811. ...
Acid Anhydride Hydrolases [D08.811.277.040]. *Adenosine Triphosphatases [D08.811.277.040.025]. *Molecular Motor Proteins [ ...
Categories: Acid Anhydride Hydrolases Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Hydrolases: 639*Acid Anhydride Hydrolases*bis(5-nucleosyl)tetraphosphatase (asymmetrical): 3. Related Diseases. 1. Shock 07/01 ... AP4A hydrolase; Ap4A phosphodiesterase (unsymmetrical); bis(5-adenosyl)tetraphosphatase; bis(5-guanosyl) tetraphosphatase; ... "By investigating the intracellular level of Ap4A hydrolase under different kinds of environmental stress, no changes occurred ...
hydrolase activity. IEA. --. GO:0016817. hydrolase activity, acting on acid anhydrides. IEA. --. ... 2897 amino acids. Molecular mass:. 326022 Da. Quaternary structure:. *Interacts with PPARA. Probably interacts with ESR1 and ... GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is ...
... acting on acid anhydrides, in phosphorus-containing anhydrides ; GO:0016818. A check of the proposed sibling terms should ... For example, thiamin-triphosphatase activity, EC:3.6.1.28, should be added under the parent EC:3.6.1.-, hydrolase activity, ... i]retinoic acid receptor activity. The gene product retinoic acid receptor alpha could be annotated to retinoic acid receptor ... We would annotate retinoic acid receptor alpha to both retinoic acid receptor activity and transcription regulator activity. ...
Pyrophosphatases are acid anhydride hydrolases that act upon diphosphate bonds. Examples include: Inorganic pyrophosphatase ...
Acid Anhydride Hydrolases/genetics. *Base Sequence. *Molecular Sequence Data. *Phosphate Transport Proteins/genetics ... In addition, similarities of M. phosphovorus speA to non-actinobacterial genes are modest, with amino acid identities less than ... In addition, similarities of M. phosphovorus speA to non-actinobacterial genes are modest, with amino acid identities less than ...
Acid Anhydride Hydrolases/genetics. *Base Sequence. *Molecular Sequence Data. *Phosphate Transport Proteins/genetics ... Amino acid sequences deduced from nucleotide sequences were used as operational taxonomic units (OTUs) for the analyses. All ... Amino acid sequences deduced from nucleotide sequences were used as operational taxonomic units (OTUs) for the analyses. All ... Based on the similarity of deduced amino acid sequences, one of the M. phosphovorus PPK2s (MLP_05750) was of the C. glutamicum ...
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-UniRule ... IPR020476 Nudix_hydrolase. IPR015797 NUDIX_hydrolase-like_dom_sf. IPR020084 NUDIX_hydrolase_CS. IPR000086 NUDIX_hydrolase_dom. ... IPR020476 Nudix_hydrolase. IPR015797 NUDIX_hydrolase-like_dom_sf. IPR020084 NUDIX_hydrolase_CS. IPR000086 NUDIX_hydrolase_dom. ... Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation. Manual assertion according to rulesi ...
hydrolase activity, acting on acid anhydrides. hydrolase activity, acting on acid anhydrides, in phosphorus-containing ... Zhang DW, Cole SP, Deeley RG: Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring ... identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1. ...
hydrolase activity, acting on acid anhydrides. hydrolase activity, acting on acid anhydrides, in phosphorus-containing ...
hydrolase activity, acting on acid anhydrides. hydrolase activity, acting on acid anhydrides, in phosphorus-containing ... Nucleic Acids Res. 1990 Jul 25;18(14):4281. [PubMed:2115998 ] *Ohmstede CA, Farrell FX, Reep BR, Clemetson KJ, Lapetina EG: ...
hydrolase activity, acting on acid anhydrides. hydrolase activity, acting on acid anhydrides, in phosphorus-containing ...
  • The KOBAS analysis of differentially regulated transcripts in response to aphids and whiteflies indicated that both the insects induce the metabolism of amino acids biosynthesis specially in case of whiteflies infestation at later phase. (biomedcentral.com)
  • We also concluded that cotton shares several pathways such as phagosomes, RNA transport, and amino acid metabolism with Arabidopsis in response to the infestation by aphids and whiteflies. (biomedcentral.com)
  • In enzymology, a 5'-acylphosphoadenosine hydrolase (EC 3.6.1.20) is an enzyme that catalyzes the chemical reaction 5'-acylphosphoadenosine + H2O ⇌ {\displaystyle \rightleftharpoons } AMP + a carboxylate Thus, the two substrates of this enzyme are 5'-acylphosphoadenosine and H2O, whereas its two products are AMP and carboxylate. (wikipedia.org)
  • Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein. (nih.gov)
  • Exon amplification from cosmids covering this deleted region allowed identification of the human FHIT gene, a member of ther histidine triad gene family, which encodes a protein with 69% similarity to an S. pombe enzyme, diadenosine 5', 5''' P1, P4-tetraphosphate asymmetrical hydrolase. (nih.gov)
  • Acid Anhydride Hydrolases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • However, the assumption that Fhit operates by water attack at P 1 is insecure, not least because the lack of sequence homology between lupin and human Ap4A hydrolases and the Ap3A hydrolase from S. pombe makes it imperative to generate analogues of Ap3A that are able to resist water attack at either P 1 (P 3 ) or P 2 . (nih.gov)
  • Moreover, bis-thiation at P 1 ,P 4 in Ap4A has been observed to drive the asymmetrical Ap4A hydrolase from the brine shrimp, Artemia , actually to cleave APsPPPsA symmetrically to ADPαS, albeit at 3.4 % of the regular V max rate. (nih.gov)
  • D-glucose is first protected by forming the peracetate by addition of acetic anhydride in acetic acid, and then addition of hydrogen bromide which brominates at the 5-position. (wikipedia.org)
  • Four of the benzyl groups are removed from hexabenzylhexaazaisowurtzitane by hydrogenolysis catalysed by palladium on carbon and the resulting secondary amine groups are acetylated in acetic anhydride. (wikipedia.org)
  • Most of these differentially expressed contigs were related to genes involved in biotic, abiotic stresses and enzymatic activities related to hydrolases, transferases, and kinases. (biomedcentral.com)
  • With extra background reading, you might find out that retinoic acid receptors can function as transcriptional regulators, but there is nothing in the term name or definition to suggest any relationship with transcriptional regulators. (geneontology.org)
  • Topical delivery of 13-cis-retinoic acid by inhalation up-regulates expression of rodent lung but not liver retinoic acid receptors. (rush.edu)
  • This graph shows the total number of publications written about "Acid Anhydride Hydrolases" by people in this website by year, and whether "Acid Anhydride Hydrolases" was a major or minor topic of these publications. (umassmed.edu)
  • Sharma M, Urano F, Jaeschke A. Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. (umassmed.edu)
  • For instance, carbon-carbon bond cleavage, fatty acid hydroperoxidation, carbon-sulfur bond cleavage, and thiol oxidation are all reactions catalyzed by mononuclear iron dioxygenases. (wikipedia.org)
  • Standard reduction potentials for reactions directly involving nitrous acid are shown in the table below: The data can be extended to include products in lower oxidation states. (wikipedia.org)