Phthalic Anhydrides
Maleic Anhydrides
Acid Anhydride Hydrolases
Succinic Anhydrides
Acetic Anhydrides
Hydrolases
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
Respiration Disorders
Occupational Exposure
A novel interaction mechanism accounting for different acylphosphatase effects on cardiac and fast twitch skeletal muscle sarcoplasmic reticulum calcium pumps. (1/700)
In cardiac and skeletal muscle Ca2+ translocation from cytoplasm into sarcoplasmic reticulum (SR) is accomplished by different Ca2+-ATPases whose functioning involves the formation and decomposition of an acylphosphorylated phosphoenzyme intermediate (EP). In this study we found that acylphosphatase, an enzyme well represented in muscular tissues and which actively hydrolyzes EP, had different effects on heart (SERCA2a) and fast twitch skeletal muscle SR Ca2+-ATPase (SERCA1). With physiological acylphosphatase concentrations SERCA2a exhibited a parallel increase in the rates of both ATP hydrolysis and Ca2+ transport; in contrast, SERCA1 appeared to be uncoupled since the stimulation of ATP hydrolysis matched an inhibition of Ca2+ pump. These different effects probably depend on phospholamban, which is associated with SERCA2a but not SERCA1. Consistent with this view, the present study suggests that acylphosphatase-induced stimulation of SERCA2a, in addition to an enhanced EP hydrolysis, may be due to a displacement of phospholamban, thus to a removal of its inhibitory effect. (+info)Characterization of the nucleoside triphosphatase activity of poliovirus protein 2C reveals a mechanism by which guanidine inhibits poliovirus replication. (2/700)
The highly conserved non-structural protein 2C of picornaviruses is involved in viral genome replication and encapsidation and in the rearrangement of intracellular structures. 2C binds RNA, has nucleoside triphosphatase activity, and shares three motifs with superfamily III helicases. Motifs "A" and "B" are involved in nucleotide triphosphate (NTP) binding and hydrolysis, whereas a function for motif "C" has not yet been demonstrated. Poliovirus RNA replication is inhibited by millimolar concentrations of guanidine hydrochloride (GdnHCl). Resistance and dependence to GdnHCl map to 2C. To characterize the nucleoside triphosphatase activity of 2C, we purified poliovirus recombinant 2C fused to glutathione S-transferase (GST-2C) from Escherichia coli. GST-2C hydrolyzed ATP with a Km of 0.7 mM. Other NTPs, including GTP, competed with ATP for binding to 2C but were poor substrates for hydrolysis. Mutation of conserved residues in motif A and B abolished ATPase activity, as did mutation of the conserved asparagine residue in motif C, an observation indicating the involvement of this motif in ATP hydrolysis. GdnHCl at millimolar concentrations inhibited ATP hydrolysis. Mutations in 2C that confer poliovirus resistant to or dependent on GdnHCl increased the tolerance to GdnHCl up to 100-fold. (+info)The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. (3/700)
NS3 protein of dengue virus type 2 has a serine protease domain within the N-terminal 180 residues. NS2B is required for NS3 to form an active protease involved in processing of the viral polyprotein precursor. The region carboxy terminal to the protease domain has conserved motifs present in several viral RNA-stimulated nucleoside triphosphatase (NTPase)/RNA helicases. To define the functional domains of protease and NTPase/RNA helicase activities of NS3, full-length and amino-terminal deletion mutants of NS3 were expressed in Escherichia coli and purified. Deletion of 160 N-terminal residues of NS3 (as in NS3del.2) had no detrimental effect on the basal and RNA-stimulated NTPase as well as RNA helicase activities. However, mutagenesis of the conserved P-loop motif of the RNA helicase domain (K199E) resulted in loss of ATPase activity. The RNA-stimulated NTPase activity was significantly affected by deletion of 20 amino acid residues from the N terminus or by substitutions of the cluster of basic residues, 184RKRK-->QNGN, of NS3del.2, although both mutant proteins retained the conserved RNA helicase motifs. Furthermore, the minimal NS3 protease domain, required for cleavage of the 2B-3 site, was precisely defined to be 167 residues, using the in vitro processing of NS2B-NS3 precursors. Our results reveal that the functional domains required for serine protease and RNA-stimulated NTPase activities map within the region between amino acid residues 160 and 180 of NS3 protein and that a novel motif, the cluster of basic residues 184RKRK, plays an important role for the RNA-stimulated NTPase activity. (+info)The Saccharomyces cerevisiae YOR163w gene encodes a diadenosine 5', 5"'-P1,P6-hexaphosphate (Ap6A) hydrolase member of the MutT motif (Nudix hydrolase) family. (4/700)
The YOR163w open reading frame on chromosome XV of the Saccharomyces cerevisiae genome encodes a member of the MutT motif (nudix hydrolase) family of enzymes of Mr 21,443. By cloning and expressing this gene in Escherichia coli and S. cerevisiae, we have shown the product to be a (di)adenosine polyphosphate hydrolase with a previously undescribed substrate specificity. Diadenosine 5',5"'-P1, P6-hexaphosphate is the preferred substrate, and hydrolysis in H218O shows that ADP and adenosine 5'-tetraphosphate are produced by attack at Pbeta and AMP and adenosine 5'-pentaphosphate are produced by attack at Palpha with a Km of 56 microM and kcat of 0.4 s-1. Diadenosine 5',5"'-P1,P5-pentaphosphate, adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5"'-P1,P4-tetraphosphate or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. The enzyme, which was shown to be expressed in log phase yeast cells by immunoblotting, displays optimal activity at pH 6.9, 50 degrees C, and 4-10 mM Mg2+ (or 200 microM Mn2+). It has an absolute requirement for a reducing agent, such as dithiothreitol (1 mM), and is inhibited by Ca2+ with an IC50 of 3.3 mM and F- (noncompetitively) with a Ki of 80 microM. Its function may be to eliminate potentially toxic dinucleoside polyphosphates during sporulation. (+info)Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein. (5/700)
The non-structural protein 3 (NS3) of hepatitis C virus (HCV) possesses three activities which are likely to be essential for virus replication; a serine protease located in the N terminus and helicase and NTPase activities located in the C terminus. Sequence analysis of the helicase/NTPase domain has identified motifs indicative of the DEAD-box family of helicases. Here we present the characterization of the helicase and NTPase activities of full-length NS3, expressed as a His-tagged fusion protein in E. coli, and make comparisons with published data of NS3 helicase domain alone. The helicase and NTPase activities of full-length NS3 have been demonstrated and we have characterized the effects of amino acid substitutions on conserved motifs of NS3 helicase. Helicase and NTPase activities were dependent on Mg2+ and ATP and inhibited by monovalent cations. NS3 was able to hydrolyse all four NTPs and dNTPs to drive DNA duplex unwinding but with differing abilities. NTPase activity was stimulated by all polynucleotides tested, with poly(U) having the greatest effect. Mutational analysis of conserved motifs of NS3 helicase showed all conserved residues to be required for optimal activity. These results are in accord with a recently proposed model for NS3 helicase activity. (+info)The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers. (6/700)
We examined 2 normal pancreata, 21 primary pancreatic ductal cancers, and 19 pancreatic cancer cell lines for Fhit expression and FHIT gene status. The normal pancreas expressed Fhit protein in the cytoplasm of ductular cells, whereas interlobular and larger ducts, acini, and insulae of Langerhans were negative. Fhit protein was detected by immunoblot assay in 11 pancreatic cancer cell lines; of the 8 cell lines lacking Fhit protein, 7 lacked FHIT mRNA and 1 showed an abnormally sized transcript. DNA from five of these eight cell lines showed homozygous loss of FHIT exon 5. In 8 of the 21 primary cancers, Fhit expression was detected by immunohistochemistry. Reverse transcription-PCR analysis of 6 of the 13 cases lacking Fhit showed normal-sized FHIT product in 3 cases and a mixture of normal and abnormal products in the other 3. Sequencing showed that abnormal bands were missing variable numbers of exons. Loss of microsatellite DNA markers internal to the FHIT gene was observed in 10 of 13 primary cancers lacking Fhit protein (homozygous in two cases) and in only 1 of the 8 cancers expressing Fhit protein. In nine primary cancers, four expressing and five lacking Fhit protein, it was possible to obtain pure cancer DNA by microdissection. Three of the five microdissected cases lacking Fhit protein exhibited homozygous deletion of FHIT exon 5. In conclusion, the lack of Fhit protein in pancreatic cancers correlated with absence or alteration of FHIT mRNA and was often associated with FHIT gene anomalies. (+info)Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is an early event and is highly localized to the FHIT gene locus. (7/700)
The VHL tumor suppressor gene (TSG) at 3p25-26 is strongly implicated in the pathogenesis of clear cell renal cell carcinoma (cRCC). In addition, 3p14.2 and 3p21 are suspected of harboring additional TSGs in cRCC, with FHIT being a candidate TSG at 3p14.2. We examined 87 microdissected, histologically well-defined cRCCs classified according to tumor-node-metastasis (TNM) stage (stage 1, 23 cases; stage 2, 14 cases; stage 3, 24 cases; stage 4, 26 cases) and Fuhrman grade (grade 1, 24 cases; grade 2, 19 cases; grade 3, 19 cases; grade 4, 8 cases; sarcomatoid cRCC, 17 cases) for loss of heterozygosity (LOH) at 3p14.2 and 3p25-26 using a series of precisely mapped microsatellite probes. We found that LOH at 3p14.2 exceeded LOH at 3p25-26 in frequency (69% versus 48.3%; P < 0.03) and was highly localized to markers within the FHIT gene locus (D3S1300 and D3S4260), with the majority of chromosomal breakpoints also mapping to this region. In addition, 3p14.2 LOH (P < 0.03), but not 3p25-26 LOH (P = nonsignificant), was associated with lower tumor grades (grades 1-3). These findings suggest that 3p14.2 genomic deletions may be among the earliest events in cRCC pathogenesis, preceding genomic deletions at the VHL locus. FHIT, or an as yet undiscovered TSG mapping to the D3S4103-D3S4260 interval, could be the molecular target of the 3p14.2 deletions. (+info)Designing conditions for in vitro formation of amyloid protofilaments and fibrils. (8/700)
We have been able to convert a small alpha/beta protein, acylphosphatase, from its soluble and native form into insoluble amyloid fibrils of the type observed in a range of pathological conditions. This was achieved by allowing slow growth in a solution containing moderate concentrations of trifluoroethanol. When analyzed with electron microscopy, the protein aggregate present in the sample after long incubation times consisted of extended, unbranched filaments of 30-50 A in width that assemble subsequently into higher order structures. This fibrillar material possesses extensive beta-sheet structure as revealed by far-UV CD and IR spectroscopy. Furthermore, the fibrils exhibit Congo red birefringence, increased fluorescence with thioflavine T and cause a red-shift of the Congo red absorption spectrum. All of these characteristics are typical of amyloid fibrils. The results indicate that formation of amyloid occurs when the native fold of a protein is destabilized under conditions in which noncovalent interactions, and in particular hydrogen bonding, within the polypeptide chain remain favorable. We suggest that amyloid formation is not restricted to a small number of protein sequences but is a property common to many, if not all, natural polypeptide chains under appropriate conditions. (+info)
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Anti-Human FHIT Antibody | Human FHIT Antibody | FHIT Antibody | Fragile Histidine Triad Protein Antibody
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EC 3.6.1.52
Sequence Similarity
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bis(5-nucleosyl)tetraphosphatase (asymmetrical)
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Pyrophosphatase
... s, also known as diphosphatases, are acid anhydride hydrolases that act upon diphosphate bonds. Examples include ... In phosphorus-containing anhydrides Kukko-Kalske E, Heinonen J (1985). "Inorganic pyrophosphate and inorganic pyrophosphatase ... Inorganic pyrophosphatase, which acts upon the free pyrophosphate ion Tobacco acid pyrophosphatase, which catalyses the ...
Phosphoribosyl-ATP diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use ...
Triphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is triphosphate phosphohydrolase. This enzyme is also called inorganic ...
Acylphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is acylphosphate phosphohydrolase. Other names in common use include ...
Diphosphoinositol-polyphosphate diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is diphospho-myo-inositol-polyphosphate diphosphohydrolase. Other names in ...
Trimetaphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is trimetaphosphate hydrolase. This enzyme is also called inorganic ...
DUTP diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is dUTP nucleotidohydrolase. Other names in common use include ...
Adenylylsulfatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides ...
Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase. Other names ...
Nucleoside-triphosphate diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is nucleoside-triphosphate diphosphohydrolase. This enzyme is also called ...
Phosphoadenylylsulfatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides ...
CDP-glycerol diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Glaser L (March 1965). "The synthesis of teichoic acid IV. On the regulation of cytidine 5′-diphosphateglycerol concentration ... anhydrides. The systematic name of this enzyme class is CDP-glycerol phosphoglycerohydrolase. Other names in common use include ...
ADP-sugar diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is ADP-sugar sugarphosphohydrolase. Other names in common use include ADP- ...
Thymidine-triphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is dTTP nucleotidohydrolase. Other names in common use include thymidine ...
CDP-diacylglycerol diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Other names in common use include cytidine diphosphodiacylglycerol pyrophosphatase, and CDP diacylglycerol hydrolase. This ... anhydrides. The systematic name of this enzyme class is CDP-diacylglycerol phosphatidylhydrolase. ...
Guanosine-5'-triphosphate,3'-diphosphate diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase. Other ...
Bis(5'-adenosyl)-triphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase. Other names in ...
Adenosine-tetraphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Small GD, Cooper C (1966). "Purification and properties of nucleoside tetraphosphate hydrolase from rabbit muscle". ... anhydrides. The systematic name of this enzyme class is adenosine-tetraphosphate phosphohydrolase. This enzyme participates in ...
DCTP diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is dCTP nucleotidohydrolase. Other names in common use include ...
M7G(5')pppN diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'- ...
Nucleoside-triphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Brightwell R, Tappel AL (1968). "Lysosomal acid pyrophosphatase and acid phosphatase". Arch. Biochem. Biophys. 124 (1): 333-43 ... anhydrides. The systematic name of this enzyme class is unspecific diphosphate phosphohydrolase. Other names in common use ...
Nucleotide diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is dinucleotide nucleotidohydrolase. Other names in common use include ...
Guanosine-diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is GDP phosphohydrolase. This enzyme is also called GDPase. Raychaudhuri P ...
NAD+ diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is NAD+ phosphohydrolase. Other names in common use include nicotinamide ...
FAD diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is FAD nucleotidohydrolase. Other names in common use include FAD ...
Undecaprenyl-diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is undecaprenyl-diphosphate phosphohydrolase. Other names in common use ...
Nucleoside-diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is nucleoside-diphosphate phosphohydrolase. Other names in common use ...
Endopolyphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is polyphosphate polyphosphohydrolase. Other names in common use include ...
Oligosaccharide-diphosphodolichol diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... anhydrides. The systematic name of this enzyme class is oligosaccharide-diphosphodolichol phosphodolichohydrolase. This enzyme ...
UDP-sugar diphosphatase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing ... Glaser L, Melo A, Paul R (1987). "Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor". J. Biol. ... UDP-sugar hydrolase, and UDP-sugar pyrophosphatase. As of late 2007, 6 structures have been solved for this class of enzymes, ... anhydrides. The systematic name of this enzyme class is UDP-sugar sugarphosphohydrolase. Other names in common use include ...
G protein
Hydrolases: acid anhydride hydrolases (EC 3.6). 3.6.1. *Pyrophosphatase *Inorganic. *Thiamine. *Apyrase ... Such Gα GAPs do not have catalytic residues (specific amino acid sequences) to activate the Gα protein. They work instead by ...
Phosphate-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Aspartoacylase
Amino acid aminoacylases I and II from hog kidney. Methods Enzymol. Methods in Enzymology. Vol. 2. pp. 115-119. doi:10.1016/ ... It is a zinc-dependent hydrolase that promotes the deprotonation of water to use as a nucleophile in a mechanism analogous to ... The first uses deprotonated water and the second attacks with an aspartate or glutamate first forming an anhydride. ... Aspartoacylase is a dimer of two identical monomers of 313 amino acids and uses a zinc cofactor in each. There are two distinct ...
Taurine-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Fatty-acyl-CoA-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ... "The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces ...
Quaternary-amine-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Beta-glucan-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Glycosidic bond
D-glucose is first protected by forming the peracetate by addition of acetic anhydride in acetic acid, and then addition of ... Glycoside hydrolases (or glycosidases), are enzymes that break glycosidic bonds. Glycoside hydrolases typically can act either ... The innate utilization of sugars as solubilizing moieties in Phase II and III metabolism (glucuronic acids) has remarkably ... Pharmacologists often join substances to glucuronic acid via glycosidic bonds in order to increase their water solubility; this ...
Xenobiotic-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Epoxide
and similar epoxydocosapentaenoic acids, and epoxyeicosatetraenoic acids.) Ring-opening reactions dominate the reactivity of ... Epoxide hydrolase Juliá-Colonna epoxidation Guenter Sienel; Robert Rieth; Kenneth T. Rowbottom. "Epoxides". Ullmann's ... Julie M. Longo; Maria J. Sanford; Geoffrey W. Coates (2016). "Ring-Opening Copolymerization of Epoxides and Cyclic Anhydrides ... Peroxycarboxylic acids, which are more electrophilic, convert alkenes to epoxides without the intervention of metal catalysts. ...
Cd2+-exporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Cadmium-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Heme-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Polar-amino-acid-transporting ATPase
... and polar amino acid. This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse ... In enzymology, a polar-amino-acid-transporting ATPase (EC 3.6.3.21) is an enzyme that catalyzes the chemical reaction ATP + H2O ... Walshaw DL, Lowthorpe S, East A, Poole PS (1997). "Distribution of a sub-class of bacterial ABC polar amino acid transporter ... The systematic name of this enzyme class is ATP phosphohydrolase (polar-amino-acid-importing). This enzyme is also called ...
Nitrate-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Dephosphorylation
... employs a type of hydrolytic enzyme, or hydrolase, which cleaves ester bonds. The prominent hydrolase ... This young amino acid (Val129) may serve as a dephosphorylation site of IRF9. The dephosphorylation may affect the immune ... activate and deactivate enzymes by detaching or attaching phosphoric esters and anhydrides. A notable occurrence of ... The positive selection has been found on the amino acid site Val129 (NP_006075.3:p.Ser129Val) of human IRF9. The ancestral ...
Polyamine-transporting ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ...
Plasma membrane H+-ATPase
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane ... Acid growth. Acidification of the external medium caused by activation of the plasma membrane H+ -ATPase initiates cellular ...
Paracetamol
p-Aminophenol is then converted in the brain by fatty acid amide hydrolase into AM404, a compound that may be partially ... The classical methods for the production of paracetamol involve the acetylation of 4-aminophenol with acetic anhydride as the ... Apparently, it is formed in the brain from another paracetamol metabolite 4-aminophenol by action of fatty acid amide hydrolase ... "Ascorbic acid/Phenylephrine/Paracetamol". NHS Choices. National Health Service. Archived from the original on 26 March 2014. ...
Acid anhydride hydrolases - Wikipedia
Acid anhydride hydrolases are a class of hydrolase enzymes that catalyze the hydrolysis of an acid anhydride bond. They are ... Media related to Acid anhydride hydrolases at Wikimedia Commons Acid+anhydride+hydrolases at the US National Library of ... List of EC numbers (EC 3)#EC 3.6: Act on acid anhydrides Ashton Acton, ed. (2012). Acid Anhydride Hydrolases: Advances in ...
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GO:0016818: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides details
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YRC Public Data Repository - Protein Overview - KAR3 / YPR141C
MeSH Browser
Hydrolases [D08.811.277] * Acid Anhydride Hydrolases [D08.811.277.040] * AAA Proteins [D08.811.277.040.013] ... Acid Anhydride Hydrolases Preferred Term Term UI T053170. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1994). ... Acid Anhydride Hydrolases Preferred Concept UI. M0026851. Registry Number. EC 3.6.-. Scope Note. A group of enzymes that ... Acid Anhydride Hydrolases. Tree Number(s). D08.811.277.040. Unique ID. D017766. RDF Unique Identifier. http://id.nlm.nih.gov/ ...
Target Information | Therapeutic Target Database
GTP-Binding Protein alpha Subunits | Colorado PROFILES
KEGG ENZYME: 3.6.1.28
rap GTP-Binding Proteins | Colorado PROFILES
GTPase
... are also called GAP and they are a large family of hydrolase enzymes that can bind and hydrolyze GTP. The GTP binding and ... Hydrolases: acid anhydride hydrolases (EC 3.6). 3.6.1. Pyrophosphatase (Inorganic, Thiamine) - Apyrase - Thiamine ... Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5). 3.6.5.1: Heterotrimeric G protein. Gαs - Gαi - Gαq/11 - Gα12/13 - ... GTPases (singular GTPase) are also called GAP and they are a large family of hydrolase enzymes that can bind and hydrolyze GTP ...
Sol Genomics Network
Sodium-Potassium-Exchanging ATPase | Profiles RNS
G protein - Wikipedia
DeCS Ingl s
D08.811.277 Hydrolases .. D08.811.277.040 Acid Anhydride Hydrolases .. D08.811.277.040.330 GTP Phosphohydrolases .. D08.811. ... Acid, Ribonucleic .. Non Polyadenylated RNA .. RNA Gene Products .. RNA, Non Polyadenylated .. Ribonucleic Acid .. RNA, Non- ... D13 Nucleic Acids, Nucleotides, and Nucleosides .. D13.444 Nucleic Acids .. D13.444.735 RNA 12333 .. SP4 Environmental Health . ... D12 Amino Acids, Peptides, and Proteins .. D12.644 Peptides .. D12.644.360 Intracellular Signaling Peptides and Proteins .. ...
MutS Homolog 2 Protein | Profiles RNS
RecQ Helicases | Profiles RNS
Transcriptional profiling of the leaves of near-isogenic rice lines with contrasting drought tolerance at the reproductive...
... hydrolase and transcription factor activities, whereas in the moderate DTN, IR77298-5-6-B-18, genes with transporter, catalytic ... hydrolase activity, acting on acid anhydrides, copper ion binding, transcription regulator activity and methyltransferase ... hydrolase activity, including hydrolases, alpha-amylases and beta-amylases, were induced in rice NILs in response to severe WD ... Several of the down-regulated genes under severe WD were associated with protein amino acid phosphorylation and the ...
LOC Os02g38300.1 details
SymbC1.scaffold2932.4 details
hydrolase activity, acting on acid anhydrides. IEP. Enrichment. MF. GO:0016818. hydrolase activity, acting on acid anhydrides, ... carboxylic acid transport. IEP. Enrichment. MF. GO:0046943. carboxylic acid transmembrane transporter activity. IEP. Enrichment ... monocarboxylic acid transmembrane transporter activity. IEP. Enrichment. MF. GO:0008649. rRNA methyltransferase activity. IEP. ...
CBI65624 details
hydrolase activity, acting on acid anhydrides. IEP. Enrichment. MF. GO:0016818. hydrolase activity, acting on acid anhydrides, ... aromatic amino acid family metabolic process. IEP. Enrichment. BP. GO:0009073. aromatic amino acid family biosynthetic process ... organic acid metabolic process. IEP. Enrichment. BP. GO:0006139. nucleobase-containing compound metabolic process. IEP. ... cellular amino acid metabolic process. IEP. Enrichment. BP. GO:0006556. S-adenosylmethionine biosynthetic process. IEP. ...
InnateDB: Systems Biology of the Innate Immune Response
KHC70591 details
Ophiocordyceps camponoti-rufipedis
Enzymes4
- Acid anhydride hydrolases are a class of hydrolase enzymes that catalyze the hydrolysis of an acid anhydride bond. (wikipedia.org)
- A group of enzymes that catalyze the hydrolysis of diphosphate bonds in compounds such as nucleoside di- and tri-phosphates, and sulfonyl-containing anhydrides such as adenylylsulfate. (nih.gov)
- GTPases (singular GTPase) are also called GAP and they are a large family of hydrolase enzymes that can bind and hydrolyze GTP. (chemeurope.com)
- C 20 H 32 O 2 , an omega-6 fatty acid formed by the action of enzymes on phospholipids in cell membranes. (unboundmedicine.com)
Proteins1
- It is a building block of proteins, participates in the citric acid and urea cycles, and is a neurotransmitter. (unboundmedicine.com)
Catalytic2
- Drought tolerance in the highly drought-tolerant NIL (DTN), IR77298-14-1-2-B-10, could be attributed to the up-regulation of genes with calcium ion binding, transferase, hydrolase and transcription factor activities, whereas in the moderate DTN, IR77298-5-6-B-18, genes with transporter, catalytic and structural molecule activities were up-regulated under WD. (biomedcentral.com)
- Low-temperature swelling of cotton linter cellulose and subsequent gelatinization in trifluoroacetic acid (TFA) greatly enhance rates of enzymatic digestion or maleic acid-AlCl 3 catalyzed conversion to hydroxymethylfurfural (HMF) and levulinic acid (LA). However, lignin inhibits low-temperature swelling of TFA-treated intact wood particles from hybrid poplar ( Populus tremula × P. alba ) and results in greatly reduced yields of glucose or catalytic conversion compared to lignin-free cellulose. (biomedcentral.com)
Hydrolysis1
- Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. (ntu.edu.sg)
Carboxylic acid1
- The organic dicarboxylic acid compounds B used may in principle be any C 2 -C 40 -aliphatic, C 3 -C 20 -cycloaliphatic, aromatic or heteroaromatic compounds which have two carboxylic acid groups (carboxyl groups) or derivatives thereof. (justia.com)
Amino acid7
- The biosynthesis of each Amino acid is carried out in a unique pathway from that of another. (clinicalbiochem.com)
- This is because each of the amino acid, especially the 20 common amino acids, has a distinct structure. (clinicalbiochem.com)
- It is involved in the removal of amino groups through transamination reactions and in donation of amino groups for various amino acid biosynthetic pathways. (clinicalbiochem.com)
- FH4 is used in both amino acid degradation (e.g. (clinicalbiochem.com)
- Glutamate The amino acid biosynthesis of glutamate catalyzed by the transfer of an amino group to the α-ketoglutarate by glutamate dehydrogenase, a mitochondrial enzyme, in what is termed reductive amination reaction. (clinicalbiochem.com)
- D-amino acid oxidase and L-amino acid oxidase. (lookformedical.com)
- C 4 H 7 NO 4 , a nonessential amino acid. (unboundmedicine.com)
Essential amino3
- Essential amino acids are those that must be present in a diet, and which the body cannot synthesize. (clinicalbiochem.com)
- The pathway for the synthesis of essential amino acids are found in plants and in bacteria, but not in animals. (clinicalbiochem.com)
- Its essential amino acids improve insulin level in the blood. (forestaorganics.com)
Esters2
- Preference is given to using the dicarboxylic acids, especially butanedioic acid, hexanedioic acid, decanedioic acid, dodecanedioic acid, terephthalic acid and/or isophthalic acid or the corresponding dimethyl esters thereof. (justia.com)
- 1985. Mutagenicity evaluation of phthalic acid esters and metabolites in Salmonella typhimurium cultures. (cdc.gov)
Pyridoxal2
- During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). (lookformedical.com)
- The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. (lookformedical.com)
Acetic acid1
- Glacial (highly purified) acetic acid contains at least 99.5% acetic acid by weight. (unboundmedicine.com)
Aspartic acid3
- Most FT homologs are known to share a constellation of five charged residues, three of which, i.e., two histidines and an aspartic acid, are located at the rim of a well-defined cavity on the protein surface. (biomedcentral.com)
- Aspartic acid. (unboundmedicine.com)
- C 10 H 18 N 4 O 6 , a compound intermediate in the synthesis of arginine, formed from citrulline and aspartic acid. (unboundmedicine.com)
Acting1
- Hydrolases, Acting on acid anhydrides, In phosphorous-containing anhydrides. (uma.es)
Genus1
- C 17 H 11 NO 7 , an acid derived from Aristolochia , a genus of flowering plants, and used as an herbal remedy. (unboundmedicine.com)
Synthesis3
- However, some generalities do apply to both the synthesis and the degradation of all amino acids. (clinicalbiochem.com)
- This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. (lookformedical.com)
- Synthesis of Succinyl Norcocaine (SNC) A remedy of 382 mg (1.3 mmol) norcocaine 264 mg (2.6 mmol) succinic anhydride and 0.5 mL diisopropylethylamine or Hünigs base (DIPEA) in 10 mL of CH2Cl2 (DCM) was heated at reflux overnight. (cancerhugs.com)
Catalysis1
- Low-temperature (− 20 °C) treatment of S-lignin-rich poplar wood particles in TFA slightly increased yields of glucose from enzymatic digestions and HMF and LA from maleic acid-AlCl 3 catalysis. (biomedcentral.com)
Trifluoroacetic1
- The merchandise was stirred in 15 mL DCM and 1 overnight.5 mL trifluoroacetic acid washed with sat. (cancerhugs.com)
Hydrogen1
- An acid containing hydrogen and one other element. (unboundmedicine.com)
Class1
- ABBR: AHA Any of a class of water-soluble acids derived from fruit or milk, having a hydroxyl moiety in the first position in the molecule. (unboundmedicine.com)
Nonessential2
- The 20 amino acids found in human body can be classified into essential and nonessential amino acids. (clinicalbiochem.com)
- Nonessential amino acids need not be present in the diet. (clinicalbiochem.com)
Urea1
- Other treatments, such as NaOH/urea or 85% phosphoric acid, solubilize cellulose for improved saccharification yield [ 10 ]. (biomedcentral.com)
Carboxyl1
- Proline The initial reaction converts ϒ-carboxyl group of glutamate to the mixed acid anhydride of glutamate ϒ-phosphate, which is subsequently reduced to glutamate ϒ-semialdehyde, and after cyclization reaction, it is reduced to L-proline. (clinicalbiochem.com)
Derivative1
- Saccharin is a derivative of this acid. (unboundmedicine.com)
Yields1
- It is an object of the present invention to provide a novel process for preparing aqueous polyamide dispersions, which affords the aqueous polyamide dispersions in aqueous medium directly from the diamine component and the dicarboxylic acid component, without an additional dispersion/distillation stage, in good yields. (justia.com)
Water1
- H 3 BO 3 , a white crystalline acid that in water forms a very weak acid solution poisonous to plants and animals. (unboundmedicine.com)
Present1
- C 4 H 8 O 3 , any of the acids present in the urine, esp. (unboundmedicine.com)
Term1
- 4. Slang term for lysergic acid diethylamide (LSD). (unboundmedicine.com)
Complex1
- Any of the complex acids that occur as salts in bile, e.g., cholic, glycocholic, and taurocholic acids. (unboundmedicine.com)
Reaction1
- A process for preparing an aqueous polyamide dispersion by enzyme-catalyzed polycondensation reaction of a diamine compound and a dicarboxylic acid compound in aqueous medium. (justia.com)
Found1
- The acid is found in many foods. (unboundmedicine.com)
Conversion1
- in diabetic ketoacidosis, when the conversion of fatty acids to ketones increases. (unboundmedicine.com)
Plants1
- C 18 H 30 O 2 , an omega-3 fatty acid derived from plants, esp. (unboundmedicine.com)
Form1
- An acid reacts with a metal to form a salt, neutralizes bases, and turns litmus paper red. (unboundmedicine.com)