Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.Anemia, Pernicious: A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)Vipoma: A tumor that secretes VASOACTIVE INTESTINAL PEPTIDE, a neuropeptide that causes VASODILATION; relaxation of smooth muscles; watery DIARRHEA; HYPOKALEMIA; and HYPOCHLORHYDRIA. Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. In most cases, Vipomas are located in the PANCREAS but can be found in extrapancreatic sites.Parietal Cells, Gastric: Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.Gastrins: A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.Zollinger-Ellison Syndrome: A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.Gastric Juice: The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)Gastric Acid: Hydrochloric acid present in GASTRIC JUICE.Mucolipidoses: A group of inherited metabolic diseases characterized by the accumulation of excessive amounts of acid mucopolysaccharides, sphingolipids, and/or glycolipids in visceral and mesenchymal cells. Abnormal amounts of sphingolipids or glycolipids are present in neural tissue. INTELLECTUAL DISABILITY and skeletal changes, most notably dysostosis multiplex, occur frequently. (From Joynt, Clinical Neurology, 1992, Ch56, pp36-7)Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Pepsin A: Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.Esophageal pH Monitoring: Analysis of the HYDROGEN ION CONCENTRATION in the lumen of the ESOPHAGUS. It is used to record the pattern, frequency, and duration of GASTROESOPHAGEAL REFLUX.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Seizures, Febrile: Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)Complementary Therapies: Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (PHYSICAL THERAPY MODALITIES; DIET; ACUPUNCTURE) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment.Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Gastritis, Atrophic: GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Vitamin D Deficiency: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.Vitamins: Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.Iron Chelating Agents: Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.Poly A: A group of adenine ribonucleotides in which the phosphate residues of each adenine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Fagopyrum: A plant genus of the family POLYGONACEAE that is used as an EDIBLE GRAIN. Although the seeds are used as cereal, the plant is not one of the cereal grasses (POACEAE).Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Calcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Proton Pump Inhibitors: Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.Calcium Gluconate: The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.Calcium Isotopes: Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.Calcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Syndrome: A characteristic symptom complex.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Intrinsic Factor: A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS.Vitamin B 12: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.Transcobalamins: A group of carrier proteins which bind with VITAMIN B12 in the BLOOD and aid in its transport. Transcobalamin I migrates electrophoretically as a beta-globulin, while transcobalamins II and III migrate as alpha-globulins.Vitamin B 12 Deficiency: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.Malabsorption Syndromes: General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.

A retrospective study of the usefulness of acid secretory testing. (1/79)

BACKGROUND: Gastric analysis is useful for diagnosing and monitoring the control of hypersecretory conditions and to distinguish appropriate from inappropriate causes of hypergastrinaemia. Pentagastrin, used to measure maximal acid output (MAO), is no longer available in the USA. METHODS: We examined the University of Pennsylvania Health System gastric analysis database, which includes demographic data, study indications, gastric analysis, and serum gastrin and secretin testing results according to referral indications, paying specific attention to discordant basal acid output (BAO) and MAO measurements. RESULTS: One hundred and twenty-four gastric analyses were performed in 103 patients (42 males, mean age 47.5 years, 14 with prior acid-decreasing surgery). Recurrent ulceration or pain unresponsive to antisecretory therapy was the indication in 42 patients. Twelve were hypersecretory, including three each with isolated elevations of BAO or MAO. Hypergastrinaemia was the indication in 35 patients. Five were hypersecretory (four with Zollinger-Ellison syndrome), three had isolated MAO elevations and 16 were hypo- or achlorhydric, indicating appropriate hypergastrinaemia. Of the seven patients with isolated MAO elevations, two had clear benefit from the stimulated portion of the study (four additional patients had equivocal benefit). CONCLUSIONS: Gastrin concentrations cannot be interpreted without knowledge of acid secretory capacity. MAO measurement has a small but significant benefit over measuring BAO alone.  (+info)

Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. (2/79)

The H,K-ATPase of the gastric parietal cell is the most critical component of the ion transport system mediating acid secretion in the stomach. To study the requirement of this enzyme in the development, maintenance, and function of the gastric mucosa, we used gene targeting to prepare mice lacking the alpha-subunit. Homozygous mutant (Atp4a(-/-)) mice appeared healthy and exhibited normal systemic electrolyte and acid-base status but were achlorhydric and hypergastrinemic. Immunocytochemical, histological, and ultrastructural analyses of Atp4a(-/-) stomachs revealed the presence of chief cells, demonstrating that the lack of acid secretion does not interfere with their differentiation. Parietal cells were also present in normal numbers, and despite the absence of alpha-subunit mRNA and protein, the beta-subunit was expressed. However, Atp4a(-/-) parietal cells had dilated canaliculi and lacked typical canalicular microvilli and tubulovesicles, and subsets of these cells contained abnormal mitochondria and/or massive glycogen stores. Stomachs of adult Atp4a(-/-) mice exhibited metaplasia, which included the presence of ciliated cells. We conclude that ablation of the H,K-ATPase alpha-subunit causes achlorhydria and hypergastrinemia, severe perturbations in the secretory membranes of the parietal cell, and metaplasia of the gastric mucosa; however, the absence of the pump appears not to perturb parietal cell viability or chief cell differentiation.  (+info)

Acute gastritis with hypochlorhydria: report of 35 cases with long term follow up. (3/79)

BACKGROUND: Between 1976 and 1987, 35 cases of acute gastritis with hypochlorhydria (AGH) were seen in our research laboratory. The aims of this study were to determine the natural history of AGH and the role of Helicobacter pylori in its pathogenesis. METHODS: Archived serum and gastric biopsy samples obtained from AGH subjects were examined for evidence of H pylori colonisation. Twenty eight of 33 (85%) surviving AGH subjects returned a mean of 12 years after AGH for follow up studies, including determination of H pylori antibodies, basal and peak acid output, endoscopy, and gastric biopsies. A matched control group underwent the same studies. RESULTS: Archived material provided strong evidence of new H pylori acquisition in a total of 14 subjects within two months, in 18 within four months, and in 22 within 12 months of recognition of AGH. Prevalence of H pylori colonisation at follow up was 82% (23 of 28) in AGH subjects, significantly (p<0.05) higher than in matched controls (29%). Basal and peak acid output returned to pre-AGH levels in all but two subjects. CONCLUSIONS: One of several possible initial manifestations of H pylori acquisition in adults may be AGH. While H pylori colonisation usually persists, hypochlorhydria resolves in most subjects.  (+info)

Heterogeneity of gastric histology and function in food cobalamin malabsorption: absence of atrophic gastritis and achlorhydria in some patients with severe malabsorption. (4/79)

BACKGROUND: The common but incompletely understood entity of malabsorption of food bound cobalamin is generally presumed to arise from gastritis and/or achlorhydria. AIM: To conduct a systematic comparative examination of gastric histology and function. SUBJECTS: Nineteen volunteers, either healthy or with low cobalamin levels, were prospectively studied without prior knowledge of their absorption or gastric status. METHODS: All subjects underwent prospective assessment of food cobalamin absorption by the egg yolk cobalamin absorption test, endoscopy, histological grading of biopsies from six gastric sites, measurement of gastric secretory function, assay for serum gastrin and antiparietal cell antibodies, and direct tests for Helicobacter pylori infection. RESULTS: The six subjects with severe malabsorption (group I) had worse histological scores overall and lower acid and pepsin secretion than the eight subjects with normal absorption (group III) or the five subjects with mild malabsorption (group II). However, histological findings, and acid and pepsin secretion overlapped considerably between individual subjects in group I and group III. Two distinct subgroups of three subjects each emerged within group I. One subgroup (IA) had severe gastric atrophy and achlorhydria. The other subgroup (IB) had little atrophy and only mild hypochlorhydria; the gastric findings were indistinguishable from those in many subjects with normal absorption. Absorption improved in the two subjects in subgroup IB and in one subject in group II who received antibiotics, along with evidence of clearing of H pylori. None of the subjects in group IA responded to antibiotics. CONCLUSIONS: Food cobalamin malabsorption arises in at least two different gastric settings, one of which involves neither gastric atrophy nor achlorhydria. Malabsorption can respond to antibiotics, but only in some patients. Food cobalamin malabsorption is not always synonymous with atrophic gastritis and achlorhydria, and hypochlorhydria does not always guarantee food cobalamin malabsorption.  (+info)

Hypochlorhydria induced by a proton pump inhibitor leads to intragastric microbial production of acetaldehyde from ethanol. (5/79)

BACKGROUND: Acetaldehyde, produced locally in the digestive tract, has recently been shown to be carcinogenic in humans. AIM: To examine the effect of iatrogenic hypochlorhydria on intragastric acetaldehyde production from ethanol after a moderate dose of alcohol, and to relate the findings to the changes in gastric flora. METHODS: Eight male volunteers ingested ethanol 0.6 g/kg b.w. The pH, acetaldehyde level and microbial counts of the gastric juice were then determined. The experiment was repeated after 7 days of lansoprazole 30 mg b.d. RESULTS: The mean (+/- S.E.M.) pH of the gastric juice was 1.3 +/- 0.06 and 6.1 +/- 0.5 (P < 0.001) before and after lansoprazole, respectively. This was associated with a marked overgrowth of gastric aerobic and anaerobic bacteria (P < 0. 001), by a 2.5-fold (P=0.003) increase in gastric juice acetaldehyde level after ethanol ingestion, and with a positive correlation (r=0. 90, P < 0.001) between gastric juice acetaldehyde concentration and the count of aerobic bacteria. CONCLUSIONS: Treatment with proton pump inhibitors leads to hypochlorhydria, which associates with intragastric overgrowth of aerobic bacteria and microbially-mediated acetaldehyde production from ethanol. Since acetaldehyde is a local carcinogen in the concentrations found in this study, long-term use of gastric acid secretory inhibitors is a potential risk-factor for gastric and cardiac cancers.  (+info)

Assessment of gastric acidity of Japanese subjects over the last 15 years. (6/79)

The gastric acidity of young to elderly Japanese subjects from 1989 to 1999 was assessed and compared with that obtained in 1984, using GA-Test capsules containing acid-dissolving granules of riboflavin. The percentage of achlorhydric subjects increased with age as observed before, however, an over all decrease in all age categories year by year was noted. The percentage of achlorhydric subjects aged 50 years in 1995-1999 was about 40%, which was lower than that (60%) in 1984. However, such a chronological change was not observed when the percentage of achlorhydric subjects was determined according to birth year, indicating that it is related to the birth year of subjects. The percentage of achlorhydric subjects correlated with infection by Helicobacter pylori. Considering the high percentage of achlorhydric elderly, bioavailability and bioequivalence studies should be performed taking into consideration the effects of gastric acidity on the in vivo performance of drug products.  (+info)

Marginal ulcer in achlorhydric patients. (7/79)

Recurrent gastrojejunal ulceration is reported in three patients with histamine-fast achlorhydria. In none of these patients was extruding suture material responsible for the ulceration. However, all three patients had a history of alcohol abuse, and one abused aspirin as well. These cases demonstrate that achlorhydria does not protect against anastomotic ulceration. It is suggested that surgical manipulation produces an increased susceptibility to mucosal damage, and that it is erroneous to consider all anastomotic ulceration as a continuation or recurrence of acid peptic disease.  (+info)

Vagal impairment of gastric secretion in diabetic autonomic neuropathy. (8/79)

Gastric acid output in response to insulin-induced hypoglycaemia and pentagastrin was measured in 18 diabetic patients with symptoms of autonomic neuropathy. Two patients had achlorhydria but the rest responded normally to pentagastrin. The acid output evoked by insulin-induced hypoglycaemia was low in 10 of the 16 patients who secreted acid in response to pentagastrin. These changes suggest that vagal impairment is common in diabetics with autonomic symptoms, which might explain the infrequency of duodenal ulcer in diabetics.  (+info)

Defective absorption of calcium has been thought to exist in patients with achlorhydria. Hunt et al found gastric secretion of acid is required for the absorption of calcium from carbonate; however, absorption of calcium from calcium monocitrate was consistent irrespective of pH.20 Recker et al also found decreased absorption of calcium from the carbonate form in patients with achlorhydria. They found absorption of calcium as a pH-adjusted citrate salt was superior to carbonate in individuals with normal gastric acidity, and absorption of the citrate salt was not negatively affected by decreased gastric acidity. In fact, their findings indicate absorption of calcium as a citrate salt was significantly higher in individuals with achlorhydria than in subjects with normal gastric acidity.27 In contrast to these studies suggesting the requirement of HCl for absorption of calcium from carbonate, Bo-Linn et al concluded stomach acid production was not important in absorption of calcium from carbonate ...
In the early twentieth century various investigators believed that patients with reduced gastric acid secretion were especially susceptible to bacterial enteric infections. Since many bacteria are promptly killed in an acidic environment, gastric acidity was thought to act as a "barrier" to ingested microorganisms. Despite a century of study, the concept of a "gastric barrier" to ingested microorganisms is still insufficiently understood. In this paper we update the older observations and discuss the interaction between bacteria and gastric acid, and other variables that may influence the survival of ingested bacteria in the stomach. In addition to recent data dealing with nontyphoidal salmonellosis, cholera, and shigellosis, we present information pertinent to other bacterial and parasitic enteric diseases. We believe that the available data, although incomplete, support the concept that gastric hypochlorhydria or achlorhydria increases both susceptibility to and severity of bacterial and ...
Inability to produce gastric acid. Most commonly caused by gastric atrophy. Gastric atrophy, with or without autoimmune gastritis, is present in about 15% of older people and is thought to be initiated by infection with . Usually asymptomatic but may present with signs and/or symptoms of iron, c...
The lowering acid level itself can make symptoms similar to gastroesophageal reflux disease, and hinders protein digestion by holding back the enzyme pepsin. Pepsin needs a low gastric PH to become active. Low acid levels in the stomach are also linked with bacteria growing too much, which can stop the body taking in nutrients or vitamins. ...
Townsend Letter for Doctors & Patients alternative medicine articles are written by researchers, health practitioners and patients.
As we age, hydrochloric acid tends to become depleted. Additionally, it is reduced by eating complex meals (thats most meals), excessive eating, and high protein intake. And if you have a sluggish thyroid gland you may be prone to insufficient hydrochloric acid.. Not only can hypochlorhydria (as it is officially called) result in nutritional deficiencies it can cause fatigue, insufficient pancreatic digestive enzymes, and food allergies. But, thats just the tip of the iceberg. Here are some of the symptoms associated with low stomach acid. Dont forget to check out my article 12 Ways to Supercharge Your Digestion to discover ways to restore stomach acid and other digestion tips.. Some symptoms and conditions associated with low stomach acid:. Asthma. Autoimmune disorders. Bloating. Candidiasis-chronic. Celiac disease. Constipation. Diabetes mellitus. Diarrhea. Dilated capillaries in the cheeks and nose (in non-alcoholics). Distention after eating. Dry mouth. Eczema. Fingernails that are weak, ...
What are the causes of no or low stomach acid? Achlorhydria or hypochlorhydria causes & risk factors are aging, H. Pylori, low estrogen, etc.
Glutamic Acid Other name(s): a-aminoglutaric acid Reported uses Glutamic acid is often used to treat hypochlorhydria and achlorhydria. Unsubstantiated claims Please note that this section reports on claims that have not yet been substantiated through studies. Glutamic acid may treat personality and childhood behavioral issues. It may also aid in epilepsy and muscular dystrophy. It may also treat intellectual disorders. Glutamic acid may be used to treat low blood sugar (hypoglycemia) in people with diab...
PCAs target gastric H+/K+ATPase (4). Acid output was lower in PCA+ patients. Achlorhydria interrupts the negative feedback of somatostatin on antral G-cells, thus inducing hypergastrinemia, a trophic stimulus for ECL cell proliferation. We and others demonstrated a positive correlation between gastrin and ECL cell density (21,27). Also, CgA levels were increased in all patients with ECL cell hyper/dysplasia. ECL cells may release CgA into the circulation (21,22). Multivariate regression showed that the CgA level was determined by ECL cell density and gastrin level, as shown before (13,21,22,28).. The degree of ECL cell hyper/dysplasia is important in determining the risk of carcinoid tumor. CgA may indicate the presence of an increased gastric ECL cell mass more accurately than histology. This is supported by the correlations we found between CgA and gastrin and ECL cell proliferative changes. The assessment of gastric ECL cell proliferation is hampered by the fact that such lesions are usually ...
Does Alka Seltzer Help Acid Reflux to find out where to get the best deal on Does Alka Seltzer Help Acid Reflux. If the Does Alka Seltzer Help Acid Reflux is integrated that you must have, be sure to order now to stay away from disappointment Click on right here to find out exactly where to get the very best deal on Does Alka Seltzer Help Acid Reflux.. For example, Prilosec (omeprazole) was the first proton pump inhibitor (PPI). It was introduced as a new and more powerful way to suppress stomach acid and fight reflux. Prilosec became a.. Which Of The Following Secretions Raises Ph And Neutralizes Stomach Acid? Stomach secretions usually have a very low pH (1-2), which means they are highly acidic. Your stomach pH may indicate the following: People with achlorhydria have almost no stomach acid. may help. Oct 01, 2019 · After the partially digested bolus leaves the stomach mixed with gastric acid and enters the small intestine via the duodenum,. Products 1 - 20 of 63. Alka-Seltzer Extra ...
Cobalamin (vitamin B12) deficiency is highly prevalent in the US and worldwide. Deficiency is most common in the elderly, with an average prevalence ≈25% over age 60 y. About 40% of older persons with low serum cobalamin have food cobalamin malabsorption (F-CM), in which gastric atrophy/achlorhydria and/or dysfunction is implicated. Because of the prevalence of deficiency in those over age 60 y, it is generally recommended that the elderly consume a higher proportion of their cobalamin from fortified foods than what is recommended for younger people. However there is considerable debate about whether crystalline cobalamin is absorbed as well by the elderly with F-CM as it is by younger people, especially if it is added as a fortificant to food. The data to be collected in this study will provide information useful to on-going deliberations concerning the future fortification of wheat flour with vitamin B12 in the United States ...
Vitamin B12 is essential for DNA synthesis and for cellular energy production. This review aims to outline the metabolism of vitamin B12, and to evaluate the causes and consequences of sub-clinical vitamin B12 deficiency. Vitamin B12 deficiency is common, mainly due to limited dietary intake of animal foods or malabsorption of the vitamin. Vegetarians are at risk of vitamin B12 deficiency as are other groups with low intakes of animal foods or those with restrictive dietary patterns. Malabsorption of vitamin B12 is most commonly seen in the elderly, secondary to gastric achlorhydria. The symptoms of sub-clinical deficiency are subtle and often not recognized. The long-term consequences of sub-clinical deficiency are not fully known but may include adverse effects on pregnancy outcomes, vascular, cognitive, bone and eye health.
Vitamin C is the L-ascorbic acid in man while the isomer D-ascorbic acid is biologically inactive. It is water soluble white in color and odorless substance with a sour taste. Ascorbic acid is easily destroyed by heat, oxidation and exposure to air especially in the presence of iron and copper ions. Alkalies also destroy it and therefore its absorption is decreased in achlorhydria. Its chemical names are ascorbic acid, and ascorbyl palmitate. Man and other animal cannot make vitamin C in their bodies and for this reason it is vitamin for them. The inability to produce this vitamin is due to lack of enzyme L-gluonolactone oxidase.. ...
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If youre a woman, addicted, abused and poor the likelihood of you or your children breaking the vicious cycle is almost impossible.
View full article , The "real" diagnosis for food-cobalamin malabsorption syndrome is hypochlorhydria. Abstract. In naturopathic medicine, we sometimes use diagnoses that are not widely used by mainstream (conventional) medicine. One such diagnosis is hypochlorhydria, which refers to an increased gastric pH as a result of deficient hydrochloric acid (HCl) and pepsin secretion. Hypochlorhydria has occasionally been mentioned as a factor in certain medical conditions (e.g., pernicious anemia, alcoholism, and partial gastrectomies),1 but has received minimal recognition as a diagnostic consideration.. Authors: Jonathan Prousky, N.D., FRSH. Keywords:food-cobalamin malabsorption syndrome, hypochlorhydria, supplemental hydrochloric acid, pepsin. ...
John McLaren-Howard has again come up with a brilliant suggestion for a simple test to diagnose hypochlorhydria. The idea here is that it is very difficult for the stomach to produce stomach acid. The normal acidity of blood is about pH7, but the acidity of stomach acid can be as low as pH 2 or below. That means that hydrogen ions (which create acidity) are a 100,000 times more concentrated in the stomach than in the bloodstream. So the stomach wall has a very difficult job to do. The gastric parietal cells need quite a bit of energy from ATP to pump hydrogen ions from the inside of the parietal cell into the lumen of the stomach. The difficult bit is stopping these hydrogen ions leaking back again. This is achieved because the gastric parietal cells forming a protective barrier between each other at the cell membrane tight junction to stop hydrogen ions leaking back. Because this is extremely hard work and the body does not want to waste energy, the main regulator for the cell membrane tight ...
Lysosomes are membrane-bound organelles that serve as the major degradative compartments for endocytic, phagocytic, and autophagic materials targeted for destruction in eukaryotic cells. Lysosomes also mediate some cell death pathways and play crucial roles in wound repair. Indeed, lysosomal dysfunction is a hallmark of many diseases, including some referred to as lysosomal storage disorders. Given this central importance of lysosomes, it is striking that little is known about how lysosomes are formed, the process we refer to as lysosome biogenesis.. Mucolipidosis type IV is a neurodegenerative lysosomal storage disorder that is characterized by severe psychomotor retardation, achlorhydria, and ophthalmological abnormalities; most tissues show lysosomal defects resulting in abnormally enlarged vacuoles that accumulate various material. In spite of this general lysosomal defect, neurons are the primary cells that die in Mucolipidosis type IV patients. Mucolipidosis type IV is due to mutations in ...
ABSTRACT. Acid-related disorders, including gastro esophageal reflux disease (GERD), duodenal ulcers, and gastric ulcers, are managed by H2 receptor antagonists and proton pump inhibitors (PPIs). PPIs represent first choice for treating acid-peptic ulcers inhibits the gastric- H+/ K+ -ATPase through covalent binding to cysteine residues of the proton pump. Achlorhydria and acute renal failure are the most common drawbacks. A reversible acid pump antagonist (APAs), currently in clinical trial removes these problems. The APAs are the conceivable future drugs for the treatment of acid-peptic disorders.. Keywords: Proton pump, Proton pump inhibitors, Acid secretion, Acid related disorders.. ...
Self-experimentation refers to the special case of single-subject research in which the experimenter conducts the experiment on himself or herself. Usually this means that a single person is the designer, operator, subject, analyst, and user or reporter of the experiment. Current champions of self-experimentation include the late Seth Roberts, Tim Ferriss, and a sprawling community of Quantified Self Human scientific self-experimentation principally (though not necessarily) falls into the fields of medicine and psychology. Self-experimentation has a long and well-documented history in medicine which continues to the present day. For example, after failed attempts to infect piglets in 1984, Barry Marshall drank a petri dish of the Helicobacter pylori from a patient, and soon developed gastritis, achlorhydria, stomach discomfort, nausea, vomiting, and halitosis.[citation needed] The results were published in 1985 in the Medical Journal of Australia, and is among the most cited articles from the ...
A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin b 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed ...
Note: Only the 100 milligram (mg) tablets can be put into a glass of water to dissolve. The 200 milligram (mg) tablets must be swallowed whole.. Do not take any antacid medications within 1 hour of the time you take delavirdine. They may prevent delavirdine from being absorbed into the body.. For patients with achlorhydria (absence of stomach acid) they should take delavirdine with a glass of orange juice or cranberry juice.. Take this medicine exactly as directed by your doctor. Do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking with your doctor first.. Keep taking delavirdine for the full time of treatment, even if you begin to feel better.. ...
1. Streeter AM, et al. Cimetidine and malabsorption of cobalamin. Dig Dis Sci 1982;27:13-16. 2. Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H 2 -receptor antagonists. Med Toxicol Adverse Drug Exp. 1988;3:430-448. 3. Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B 12 absorption. J Am Coll Nutr 1994;13:584-591. 4. Marcuard SP, et al. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B 12). Ann Intern Med 1994;120:211-215. 5. Shils M, et al. (eds.). Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins, 1999: 1634. 6. Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B 12 absorption. J Am Coll Nutr. 1194;13:584-591. 7. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H 2 receptor antagonists on the intestinal ...
The H. pylori gene was present in only 6 of the 41 samples. This was expected because, when H. pylori has been present for many years and the stomach becomes atrophic and hypochlorhydric, the intragastric environment is no longer optimal for H. pylori. Competing faecal-type organisms are then able to colonise the stomach. Furthermore, H. pylori is able to colonise only normal gastric cells, and not those that have differentiated into intestinal metaplasia. Therefore, H. pylori disappears from the stomach when atrophy and intestinal metaplasia supervene. In patients who are most likely to develop gastric cancer (those with extensive intestinal metaplasia and atrophy) and those already with advanced cancer, as in our cases, the serology is often negative and the genes will almost always not be detectable by PCR.. No significant relationship was found between age and either IL-1RN or IL-1B in gastric carcinoma from Kenyan patients; the chi-square test for both was not significant: p=0.9 for IL-1RN ...
The H. pylori gene was present in only 6 of the 41 samples. This was expected because, when H. pylori has been present for many years and the stomach becomes atrophic and hypochlorhydric, the intragastric environment is no longer optimal for H. pylori. Competing faecal-type organisms are then able to colonise the stomach. Furthermore, H. pylori is able to colonise only normal gastric cells, and not those that have differentiated into intestinal metaplasia. Therefore, H. pylori disappears from the stomach when atrophy and intestinal metaplasia supervene. In patients who are most likely to develop gastric cancer (those with extensive intestinal metaplasia and atrophy) and those already with advanced cancer, as in our cases, the serology is often negative and the genes will almost always not be detectable by PCR.. No significant relationship was found between age and either IL-1RN or IL-1B in gastric carcinoma from Kenyan patients; the chi-square test for both was not significant: p=0.9 for IL-1RN ...
It may seem like there is too much HCL acid because of heartburn, sour stomach, or overall stomach upset, nausea, and pain, but having too little stomach acid.. It may seem like there is too much HCL acid because of heartburn, sour stomach, or overall stomach upset, nausea, and pain, but having too little stomach acid.. Jun 28, 2016. Hydrochloric acid (aka stomach acid or HCl) is one of these secretions. And there are. Its about preventing gas formation, too! Beyond these.. Iron-Out-of-Balance™ in the Elderly Too Little Iron. Even though anemia is fairly prevalent among elderly persons, the underlying cause is not so easily defined.. Detecting Hypochlorhydria - Naturopathic Doctor News and Review - Jan 28, 2008. Chronic overeating Another common inhibitor of HCl production is. Hypochlorhydria occurs when the pH of the stomach falls below 3.5.. May 2, 2011. Its role in digestion and the regulation of pH in the stomach is critical for. Its important to mention that HCL production is a major ...
Calcium is an important macromineral for all the organs.Supplementation of the diet with calcium is an important factor formaintaining bone density.Calcium is removed from bone to replenishbodily stores that can become deficient during times of stress and when calcium is not supplied from food sources in sufficientamounts.Calcium in the citrate form is shown to be betterabsorbed in individuals with hypochlorhydria. Every batch is testedto ensure the absence of heavy metals and other contaminants.
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Heres a management concept from the business world that may be entirely useful for those of us living with a serious health concern. Thanks to heart attack survivor Jen Thorson for this inspirational look at the difference between our circle of influence and our circle of concern.
Heres a management concept from the business world that may be entirely useful for those of us living with a serious health concern. Thanks to heart attack survivor Jen Thorson for this inspirational look at the difference between our circle of influence and our circle of concern.
The Heidelberg test is like a window into the digestive system. It tells us about food absorption and digestion by obtaining an accurate measurement of the pH balance of the stomach. The Heidelberg pH Capsule is a high-frequency radio transmitter and pH sensor encapsulated within a special polyacrylate (plastic) covering. The capsule is about the size of a multi-vitamin and is designed to be swallowed. It measures and transmits the pH levels in the digestive system and the re-acidification time of the stomachs parietal cells. The Heidelberg Capsule system is one of the most valuable tools a doctor can have for safely and accurately determining disorders of digestion. Mal-absorption, stomach gas, belching, bloating, flatulence and irritable bowels can be addressed more thoroughly when the pH of the stomach is monitored. This test will accurately diagnose a patient who may have hypochlorhydria (low stomach acid), hyperchlorhydria (high stomach acid), achlorhydria (no stomach acid), pyloric ...
TY - JOUR. T1 - Secretin Provocation Test in the Diagnosis of Zollinger‐EIlison Syndrome. AU - Brady, Charles E.. PY - 1991/2. Y1 - 1991/2. N2 - The secretin stimulation test has become the preferred provocative test in suspected cases of Zollinger‐Ellison syndrome. A pure secretin preparation, a gastrin‐specific radioimmunoassay, and an appropriate sampling sequence are important for the proper interpretation of this test. Gastric acid analysis is necessary in the assessment of hypergastrinemia to confirm acid hypersecretion and exclude achlorhydria. When properly performed and interpreted, the secretin provocation test offers a safe, expeditious, and reliable means of evaluating patients with hypergastrinemia.. AB - The secretin stimulation test has become the preferred provocative test in suspected cases of Zollinger‐Ellison syndrome. A pure secretin preparation, a gastrin‐specific radioimmunoassay, and an appropriate sampling sequence are important for the proper interpretation of ...
Intestinal absorption was investigated in six patients with a diagnosis of primary hypogammaglobulinemia. Malabsorption was found in four patients. Low serum vitamin E levels, decreased D-xylose absorption, and increased 5-hydroxyindoleacetic acid excretion in the urine correlated with malabsorption with minor exceptions. Five patients were subjected to jejunal biopsies, and nodular lymphoid hyperplasia was found on at least one examination in each of these patients. In addition, partial to complete mucosal atrophy characterized biopsy specimens from four patients and correlated with steatorrhea with one exception. Although gastric achlorhydria (two patients), minimal to moderate pancreatic insufficiency (two patients), significant intestinal intraluminal bacterial overgrowth (three patients), and Giardia lamblia (five patients) were found, the evidence suggests that the most significant cause of malabsorption in these hypogammaglobulinemic patients is an intestinal mucosal lesion. Reversibility ...
Co-administration with atazanavir. Co-administration of atazanavir with proton pump inhibitors is not recommended. If the combination of atazanavir with a proton pump inhibitor is judged unavoidable , close clinical monitoring (e.g. virus load) is recommended in combination with an increase in the dose of atazanavir to 400 mg with 100 mg of ritonavir . A pantoprazole dose of 20 mg per day should not be exceeded.. Influence on vitamin B12 absorption. Pantoprazole, as all acid-blocking medicines, may reduce the absorption of vitamin B12 (cyanocobalamin ) due to hypo- or achlorhydria. This should be considered in patients with reduced body stores or risk factors for reduced vitamin B12 absorption on long-term therapy or if respective clinical symptoms are observed.. Long term treatment. In long-term treatment, especially when exceeding a treatment period of 1 year , patient should be kept under regular surveillance .. Gastrointestinal infections caused by bacteria. Pantoprazole, like all proton ...
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It affects males and females equally. The most common form, Adult Onset Pernicious Anemia, affects people after the age of 35 years. Studies suggest that about 1% of the elderly population is affected. Congenital Pernicious Anemia is very rare and has an onset of age between 4 and 28 months. Juvenile Pernicious Anemia has symptoms similar to the adult-onset type, seems to occur between the ages of 4 and 20 years. North America and in Europe among people of Scandinavian, English, or Irish descent has the higher prevalence. It is extremely rare among Asians. Approximately 1.9% of cases may go undiagnosed. Pernicious anemia shows a 10-fold increase in patients with multiple myeloma and a 250-fold increase in adults with immunoglobulin deficiency. ...
Over 2300-years ago the father of medicine, Hippocrates made the statement that all disorders start in the stomach. That statement is true today as it was long ago. Bronchial Asthma originates from and affliction of the stomach and gastro-intestinal tract. In many cases before the onset of the disease, patients will complain of indigestion, constipation or diarrhea abdominal pain, etc. Gastric secretion of Hydrochloric acid, following a standardized meal was studied in 200 Asthmatic children (ages 6 months to 12 years), and compared with a control group of 200 non-asthmatic children. Clinical studies show that 85% of the Asthmatic children had pH levels of Hydrochloric acid in their stomachs below normal, while only 2% of the non-asthmatic children has similar low acid levels. The study showed that the lack of sufficiently strong acid in the stomach (Hypochlorhydria) prevented the activation of the peptic enzymes. This resulted in incomplete digestion of the food and macromolecule absorption. ...
of them : I have confirmed pernicious anemia (confirmed by bone marrow biopsy ), in which I have to get ...-Italian ancestry to be able to cause the pernicious anemia , and the thallesemia, even though these diseases seem ...
List of 24 disease causes of Pernicious anemia, patient stories, diagnostic guides. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Pernicious anemia.
Hi, I am really getting down about this. I have been on B12 injections 12 wkly for years for low B12 but was tested and told I do not have pernicious anaemia. There is family history though as my...
Learn more about Pernicious Anemia at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
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Hi, has any research been done with regard to vitamin B12 deficiency in people with PD? My husand is going through a difficult phase with this deficiency; the symptoms of which appear to mimic PD such as protein problem…
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Hi all. I currently receive injections from the doctor every 8 weeks, which after reading on here Im very lucky to get in the UK.. it would seem! However my symptoms start returning after 5/6 weeks...
We got this book after reading an article in the Wall Street Journal. From Day 1, my husband felt better. His spirits are up, and I see the joyful and optimistic man I married returning! He sees the results, and has become absolutely manic about sticking to the diet. During the first few days he was worried about all the things he couldnt eat - now he raves about all the things he still CAN eat, and is loving it all ...
Im not sure I will be of much assistance but Ill give it a shot. B12 is usually stored up in the body in large supplies so it takes a chronic shortage in the diet to end up being low on B12. One of the few ways to become low is to have pernicious anemia, were one cannot absorb B12 from the GI tract ...
Hello everyone. Up until last year I was an agnostic. I made up my mind when despite praying to god to help my dying mother, she passed away due to a genetic disorder (pernicious anemia) that was left
Mucolipidosis type IV (MLIV) is a lysosomal storage disease caused by mutations in the MCOLN1 gene, which encodes the lysosomal transient receptor potential ion channel mucolipin-1 (TRPML1). MLIV causes impaired motor and cognitive development, progressive loss of vision and gastric achlorhydria. How loss of TRPML1 leads to severe psychomotor retardation is currently unknown and there is no therapy for MLIV. White matter abnormalities and a hypoplastic corpus callosum are the major hallmarks of MLIV brain pathology. Here we report that loss of TRPML1 in mice results in developmental aberrations of brain myelination due to deficient maturation and loss of oligodendrocytes. Defective myelination is evident in Mcoln1−/− mice at post-natal day 10, an active stage of post-natal myelination in the mouse brain. Expression of mature oligodendrocyte markers is reduced in Mcoln1−/− mice at post-natal day 10 and remains lower throughout the course of disease. We observed reduced Perls staining in ...
Ketoconazole is an oral or topical synthetic dioxolane imidazole compound that interferes with the biosynthesis of ergosterol, leading to alterations in certain membrane-associated cell functions. It has a high affinity for keratin and a broad spectrum of activity which includes both dermatophytes and yeasts. The risk of hepatitis, albeit rare (1 in 10 000 to 1 in 15 000 of patients treated with a medium time of onset of one month), makes ketoconazole a secondary choice for dermatophyte infections. However, ketoconazole has become the drug of choice for treating Malassezia infections and is an important adjunct in the treatment of AIDS patients with fluconazole-resistant Candida infections. Ketoconazole is not absorbed systemically following topical application, but is well absorbed orally under acid conditions. It is poorly absorbed in patients with achlorhydria and in those taking antacids or H2 receptor antagonists. The usual adult dose is 200-400 mg/day depending on the infection being ...
Mucolipidosis Type IV is an autosomal recessive disorder, mainly seen in Jews of Eastern European background. A cation channel disorder, characterized by severe neurological and ophthalmologic abnormalities, ML4 usually presents during the first year of life with mental retardation, corneal opacities, and delayed motor milestones. Children with ML4 typically reach a maximum developmental age of 15 months.
Get information, facts, and pictures about Pernicious Anemia at Encyclopedia.com. Make research projects and school reports about Pernicious Anemia easy with credible articles from our FREE, online encyclopedia and dictionary.
Background: Pathophysiologic actions of Helicobacter pylori colonization on gastric acidity have been hypothesized to modulate the effect of pancreatic carcinogens, through CagA-negative organism strain type, hyperchlorhydria and increased risk of pancreatic cancer, or CagA-positive strain, hypochlorhydria and decreased risk of pancreatic cancer. We aimed to determine H. pylori strain-specific associations with pancreatic cancer in a population in which colonization by CagA-positive strains is common.. Methods: We carried out a large population-based case-control study of pancreatic carcinoma in Shanghai, China. Venipuncture specimens were obtained from a representative sample of 761 case patients and 794 randomly selected control subjects matched by category of age and gender. Antibody seropositivity for H. pylori and its virulence protein CagA were determined by commercial enzyme-linked immunosorbent IgG assays.. Results: Compared with individuals seronegative for both H. pylori and CagA, ...
Hypochlorhydria, or low stomach acid, is a commonly overlooked problem that is linked to other diseases like stomach cancer, asthma and rheumatoid arthritis.. Causes of Late Period when Negative. - Is your period late and you have a negative pregnancy test? Late periods are so scary and nerve wracking, especially when you are sexually active.. Gerd Clinical Trials The purpose of this study is to determine the safety and effectiveness of two separate procedures to treat gastroesophageal reflux disease (GERD) also known. Feb 6, 2006. This study will. Theres more where this came from! Enter your email to become part of the Chris Kresser community and get information like this delivered straight to your inbox.. Is your period late and you have a negative pregnancy test? Late periods are so scary and nerve wracking, especially when you are sexually active.. Find a comprehensive guide to possible side effects including common and. Heartburn:Foods to Eat, Foods to Avoid. cough with mucus, chest pain, ...
Not necessarily. Here is a link to one article. According to some other things Ive read scattered around, low HCL can cause a condition where the sphincter at the top of the stomach can loosen up, causing the regurgitation of stomach acid. At one point I had started waking up sometimes choking on my own stomach acid after I would inhale it while sleeping. Terrified me every time. However, what I would suggest would be to try some enzymes (stopping the prilosec during the trial obviously) and see how you feel. If it appears to help, next time you visit a doctor, bring this up along with your experiment and ask to be tested for Hypochlorhydria. I have a specific brand that Ive found works well for me, and if you like Ill post the link. I prefer this specific brand because Ive never experienced any cross-contamination issues for gluten, and it also contains some other digestive enzymes. On a related note though, dont take more than the recommended supplement amount as too much stomach acid can ...
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Hello, I am feeling a bit confused about a possible (or possibly not) diagnosis of Pernicious Anemia. I am hoping those of you with experience in having this ruled in or out might share your wisdom. I apologize upfront for this being a long post. A little history... 1. My B12 levels have been low for a while. When
and the not so good part?. Well, about 6 weeks before my Pernicious Anaemia diagnosis, I started experiencing numbness and tingling, like pins and needles but not quite that, in my finger tips. As it was only in my left hand initially I (stupidly!) put this down to excessive guitar playing. Thats really quite terrible terminology because as any musician knows there is, of course, No Such Thing as excessive guitar playing! Pfft!. Anywho… despite finding it really strange I actually just ignored it for a couple of weeks. Until it spread to my other hand. Actually, I would have probably ignored this too if it hadnt been for the horrendous neck and back clicking that Id been experiencing for a number of months as well as the interference with guitar practice. Now, I dont go rushing off to the docs for the slightest ache and pain (childbirth with no pain relief gives me a pretty high threshold for deciding whats painful and whats not!) but when there are multiple symptoms cropping up then ...
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Addisonian or idiopathic pernicious anemia is a complex disease resulting from a lack of specific factors necessary (1) for the normal growth and development of
There are a number of clinical questions that our services receive that occur with a fair degree of regularity, a few examples:Is there any benefit in prescribing statins in the elderly?What is the frequency of vitamin b12 injections in pernicious anaemia?We answer these as best as the service can. However, we can only report on…
Mean Age of Onset 50.2 Years Symptom Checker: Possible causes include Pernicious Anemia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Perhaps the RBA should start thinking about bringing the official cash rate to another level of emergency before weakening household spending turns into a vicious cycle.
Doctors treat pernicious anemia by replacing the missing vitamin B12 in the body. People who have pernicious anemia may need lifelong treatment. The goals of treating pernicious anemia include:
A strong antiseptic and antifungal. It has a strong effect on the liver, stimulating bile formation and expulsion. Useful in cases of upper respiratory infection including tonsillitis, strep throat, sore throat, sinus infection, post nasal drip and uvulitis where there is excess mucus. Goldenseal has a long tradition of use as a local antibacterial, especially to the skin, throat, sinuses and urinary tract. Rich in alkaloids, especially the intense yellow colored berberine, this herb has shown activity against a wide range of pathogens including Staphylococcus, Klebsiella pneumoniae, Streptococcus pyogenes, E. coli, Chlamydia trachomatis, Candida albicans, Leishmania donovanii, and Entamoeba histolytica. Because it is bitter, Goldenseal will stimulate digestion and absorption, but long term use will impair digestion by killing beneficial flora in the gut. In clinical trials, Goldenseal was beneficial in the treatment of hypochlorhydria, chronic cholecystitis, acute gastroenteritis, bacillary ...
In the present paper are presented the considerations which have convinced the writer that pernicious anemia and sprue are two distinct disease entities, and that the former is not a final picture of the latter or vice-versa, as Christian (1) and others have suggested. On the basis of a detailed study of 45 cases of sprue in Porto Rico, the conclusion has been reached that in the average case the diagnosis is easily made by the general practitioner in routine examination. It is only occasionally, and this in the advanced stage of sprue,-the so-called sprue cachexia,-that the clinical picture bears such a resemblance to pernicious anemia as to readily lead to confusion. Even in these instances the writer is convinced that a thorough clinical and laboratory examination by the ordinary methods available in the average hospital will establish an absolute diagnosis in over 75 per cent of the cases.
Question - 22 yr old, diagnosed with Pernicious Anemia. On injections, sublingual pills, Adderall for ADD. Switched to Ritalina la, feeling tired, dizzy. How to cure it?. Ask a Doctor about uses, dosages and side-effects of Ritalin, Ask a Hematologist
B-12 shots are given to prevent or correct a deficiency of vitamin B-12, reports Mayo Clinic. These shots are also given to people with a condition called pernicious anemia. Pernicious anemia is a...
Stress leads to chronic activation of the neuro endocrine system and contributes to many health related disorders including obesity. Dr. Shehla Shaikh, Consultant Endocrinologist, Saifee Hospital, Mumbai reveals more information in this regard.
As of November, more than 100,000 Kansans had their drivers licenses suspended for not paying traffic tickets. This is a problem, according to Oletha Faust-Goudeau, a state senator who recently introduced legislation to help more people get restricted licenses so they can drive to work.
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As the last several years catapulted into an economic collapse and continued global warming, the belief that we were invincible, that anything was possible for us to handle, dwindled. Stress that used to be manageable became impossible. We succumbed to Fear-fear for our future, for our jobs, for our homes, for our environment, for our health, for our children-and felt alone. With Fear has come the Fear Response, meaning more physical, mental and emotional breakdowns, less capability of handling stress, and a vicious cycle. ...
A collapse of privateequity investment this year seems increasingly emblematic ofFrances deep-seated economic problems and how hard it may proveto change a vicious cycle of poor growth and weakened companies.
Introduction: Gastric endocrine tumors (GET) are increasingly recognized due to expanding indications of upper gastrointestinal endoscopy. Often silent and benign, GET may also be aggressive when sporadic and may sometimes mimic the course of gastric adenocarcinoma. Current incidence of GETs is estimated at around 8% of digestive endocrine tumors. Yearly age-adjusted incidence is around 0.2 per population of 100,000. Gastric carcinoids (ECLomas) develop from gastric enterochromaffin-like cells (ECL cells) in response to chronically elevated gastrin. Type 1 tumors (ECLomas in the course of atrophic gastritis) may occur in conditions of achlorhydria secondary to auto-immune atrophic fundic gastritis. It occurs mostly in women and they are non-functioning tumors, typically found during upper GI endoscopy performed for dyspepsia. ECLomas present frequently as multiple polyps, usually , 1 cm in diameter in the gastric fundus. Type 1 tumors are almost exclusively benign lesions with little risk of ...
Hypochlorhydria or low stomach acid, is a commonly overlooked problem that is linked to diseases like stomach cancer, asthma & rheumatoid arthritis.. Antacid tablets or liquids may curb nausea and acid reflux by neutralizing stomach acids. Get a prescription.. I nodded and exaggeratedly placed my hand over my still queasy stomach. After looking somewhat confused and. Stress had found a way to physically wreck me, compounded over the years by genuine acid reflux and gastritis.. All Alka-Seltzer varieties contain sodium bicarbonate (also known as baking soda), which will help settle a queasy belly by neutralizing stomach acid. Still, other ingredients, notably aspirin and citric acid, may irritate your stomach after a.. Bland foods are a lifesaver when dealing with a queasy stomach. Talk to your doctor about vitamin supplements. Stale breath can worsen morning sickness symptoms, and lingering acid from throwing up can erode the enamel on your teeth.. Running Doc: Avoid queasy stomach with ...
Pernicious anaemia is a result of your bodys immune system attacking the cells within the stomach that produce a protein vital for the absorption of vitamin B12.. Meat, fish and dairy products all naturally contain Vitamin B12, which is normally absorbed into the body through the stomach. For this process to occur, gastric parietal cells in the stomach release a protein called intrinsic factor.. People who have pernicious anaemia unfortunately produce antibodies which attack these gastric parietal cells. As a result, the amount of intrinsic factor. Due to this deficiency the body is anaemic because it cannot produce red blood cells that are fully functional and therefore do not carry enough oxygen.. As vitamin B12 is crucial for many biochemical reactions, such as protecting your nerve cells through myelin production, converting fat into energy, and supporting red blood cell production, the results of pernicious anemia can be debilitating.. As mentioned above, eating meat and dairy products ...
Anemia is a deficiency in red blood cells. Iron, B12 and folic acid are required to produce red blood cells. Pernicious anemia is a condition in which there is thinning of the lining of the stomach with a subsequent lack of production of a substance called intrinsic factor. Intrinsic factor is produced by the cells of the stomach - it is required for the absorption of B12 from the small intestine. So, sufferers of this condition become vitamin B12 deficient. This situation causes anemia ...
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This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009 ...
My 12 year old son was diagnosed with IBD a year ago and we bought the book and started the diet right away. He got immediate relief from his symptoms and although he has had a couple flares, Im sure if not for this diet, he would be so much worse! The book is easy to follow, contains recipes, and is a wealth of information. The diet is one we should ALL follow, as it eliminates all processed/junk food and focuses on good healthy food. Elaine is a scientist who saw this diet save her daughter and wants to share it with as many others as possible. I strongly recommend it to everyone I know ...
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When I read that passage, I had to set the book down. It, of course, led me to think about times in my own life where I was stuck in a vicious cycle. Its all the more frightening when you realize that Shannons Rat only had to choose between four directions, using only two bits of memory. Our mazes are gigantic and there are so many more exits for each square. So many more bits to keep track of. In the midst of a repeating loop, isnt it tempting to switch on or off another bit here or there and pretend thats going to fix it all. Even as we hit the same square five and six times, we still think if we maybe just alter things a little, it should be enough. Shannons Rat was able to make six repetitions before the Antineurotic Circuit said "You learned some bad information. Take a brand new path." Something tells me our counters go just a tad higher than that ...
The gastric autoantigens. The two autoantigens targeted by autoantibodies are components unique to the gastric parietal cell in the. Figure 1 The gastric parietal cell antibody detected by immunofluorescence and illustrated here on murine gastric mucosa reacts with the cytoplasm of gastric parietal cells. Characteristic of the Immunofluorescence reaction is the denser staining of the newly formed cells at the base of the mucosa (bottom left) and lighter staining of the mature cells towards the top of the mucosa. Experimental evidence suggests that the autoantigen in the parietal cell is the enzyme H+,K*-ATPase which is involved in production of acid secreted into the gastric juice.. body of the stomach. The autoantigen with which GPCA reacts is the enzyme H+,K+-adenosine triphosphatase (H+,K+-ATPase) which is cell-specific but not species-specific, indicating the importance of the physiologic role of the molecule in the gastric parietal cell. The second autoantigen is a secreted product of the ...
High specificity for pernicious anaemia. A positive result is sufficient to establish the diagnosis.. Sensitivity is low thus a negative result does not exclude the diagnosis of pernicious anaemia.. Type 1 (blocking) antibody prevents the attachment of vitamin B12 to intrinsic factor: present in 50-60% of patients with pernicious anaemia.. Type 2 (precipitating) antibody prevents attachment of the vitamin B12-intrinsic factor complex to ileal receptors: present in 30% of patients with pernicious anaemia, and only in those who also have Type 1 antibodies.. Immunoassay kits which rely on blocking function of antibodies are usually less sensitive.. ...
People with frequent headaches sometimes find themselves in a vicious cycle of experiencing more and more pain while taking more and more...
சொளிங்கர்-எலிசன் கூட்டறிகுறி (Zollinger-Ellison syndrome) என்பது புத்திழையப் பெருக்கத்தால் இரைப்பையில் மிகையாக அமிலம் சுரக்கப்பட்டு வயிற்றுப் புண் ஏற்படுதல் ஆகும். இது ஒரு நரம்பிய அகஞ்சுரப்பியப் புத்திழையப் பெருக்கம் ஆகும். காசுத்திரின் எனும் இயக்குநீரைச் சுரக்கவல்ல காசுத்திரின் புத்திழையத்தால் இந்நோய் ஏற்படுகின்றது.[1] இரையகச் சுவரணுக்கள் (parietal cell) இரையகக்காடியைச் (ஐதரோகுளோரிக் காடி) ...
The vicious cycle that youre stuck in. One of the consequences of your lower self-esteem is a lack of respect and love towards yourself. This promotes even more addictive behavior, and in turn, even more negative feelings. You must break this vicious cycle to stop an addiction. Obviously, deep within you are longing for love, like anybody is.. There is a psychological rule: the more love you give to others, the more you find back love for yourself. Whenever you do something good for others, you strengthen respect for yourself. Engaging in acts of charity can help you escape the vicious cycle described before. The effect is even stronger if you manage to be good towards others in moments of craving, i.e. if you help others instead of giving in to your addiction.. Example of what you could do. Lets look at some examples of what you could do. You could donate money to cancer aid organizations, to help protect the rainforest, to help poor children in Africa or Asia. You could volunteer at a pet ...
Making injectable B12 available over the counter from pharmacies will help save lives and will help to save money and time for the NHS.. You may have been denied your B12 injections due to COVID 19.. You may have failed to achieve a diagnosis due to your GPs lack of knowledge of the condition.. You may be struggling with your symptoms due to under treatment of your deficiency.. You may be buying supplies from another country due to lack of treatment from your GP.. You may however, be in the enviable position of being allowed to collect your prescribed ampoule from a chemist and have been taught by your GP Practice to self inject.. Whichever bracket you fall into, can you help? Do you want to be able to buy B12 OTC from your pharmacy?. Do you want to be able to treat yourself when you need to, rather than when restrictive guidance allows?. NOW is the time to act, to take your future into your own hands and try with me to make B12 OTC.. Our Struggling NHS. The NHS was in trouble long before COVID ...
People with all types of medical conditions, diseases and medication questions ask the experts, our doctors, about treatments, home remedies, drug side effects, disease symptoms, diagnosis, prognosis, and prevention.
There are two main consequences of low stomach acid: 1. You become protein malnourished. When your stomach acid is low, you are not able to digest protein. Improper digestion of protein creates toxins in your intestines that can set the stage for illness and disease. Improper digestion of protein also creates acidic blood, since protein is by nature acidic. 2. You become mineral deficient. As your blood becomes more acidic, it will look for minerals from anywhere in your body, in order to get your blood to its more ideal alkaline state. Acidic blood robs your body of minerals, even taking minerals from your bones (which is important to know if you want to prevent osteoporosis).. "Low stomach acid eventually creates a vicious cycle: low stomach acid = low minerals = acidic blood. This cycle continues because acidic blood further creates low minerals and low stomach acid. Once this vicious cycle has started, there is a cascade of consequences: You could eat plenty of protein and still be protein ...
Originally Posted by Hopes Well, lets clarify. Were talking about B12 deficiencies and Pernicious anemia, not Iron anemia. Routine tests run on
Minot-Murphy diet The use of large amounts of raw liver in the treatment of pernicious anaemia. First successes in the treatment of this disease occurred with this diet and led to development of liver extract for treatment. ...
Regular exercise, including walking and even swimming, should be encouraged in patients with cirrhosis, to prevent these patients from slipping into a vicious cycle of inactivity and muscle wasting. D... more
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Achlorhydria-induced malabsorption. *Deficient intake. *Deficient intrinsic factor, a molecule produced by cells in the stomach ...
Achlorhydria is also a feature. During attacks of diarrhea, flushing similar to the carcinoid syndrome occur rarely. Besides ... achlorhydria (hence WDHA-syndrome, or pancreatic cholera syndrome), acidosis, vasodilation (flushing and hypotension), ...
... Syndrome is multiple in 1/5 cases,. Incidence of Gastric Carcinoid is increased in Achlorhydria,Hashimoto's ...
Achlorhydria Hypochlorhydria Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier. ...
Achlorhydria is another autoimmune disease of the parietal cells. The damaged parietal cells are unable to produce the required ...
Reacidification time is vitally important in determining hypochlorhydria, hyperchlorhydria and achlorhydria. The second method ... Achlorhydria (no acid production), Pyloric Insufficiency, Heavy Stomach Mucus (from infection or ulceration), Acute and Sub- ...
BLS has also been associated with achlorhydria, dysmotility, fistulae, and strictures. Chronic or high dose opioid therapy may ...
... achlorhydria. Achlorhydria in these patients results in an increase in blood gastrin levels. These symptoms typically manifest ... achlorhydria, and failure in the maintenance of retinal tissue. Diagnosis includes genetic testing and Gastrin blood test to ...
Definition In patients suffering from achlorhydria, there is deficient secretion of HCl in stomach. In such cases acidifiers ...
... -/- mice exhibit achlorhydria, gastric hyperplasia, and mis-trafficking of KCNQ1 to the parietal cell basal membrane. The ...
Many patients then experience a condition known as achlorhydria, where there is not enough acid in the stomach. As a result of ...
Twenty-four-hour pH monitoring reveals hypochlorhydria or achlorhydria, and a chromium-labelled albumin test reveals increased ...
... and achlorhydria. Type A gastritis primarily affects the body/fundus of the stomach, and is more common with pernicious anemia ...
Having too little or no gastric acid is known as hypochlorhydria or achlorhydria respectively and are conditions which can have ...
found that a mutation of the pump's α subunit led to achlorhydria which resulted problems with iron absorption, leading to iron ...
... and can occur even in patients with achlorhydria. Ulceration risk increases with therapy duration, and with higher doses. To ...
... and achlorhydria (due to inhibition of gastrin release). Somatostatinomas are commonly found in head of pancreas. ...
... achlorhydria, stomach discomfort, nausea, vomiting, and halitosis.[citation needed] The results were published in 1985 in the ...
In hypochlorhydria and achlorhydria, there is low or no gastric acid in the stomach, potentially leading to problems as the ...
Calcium citrate can be taken without food and is the supplement of choice for individuals with achlorhydria or who are taking ...
... because they are more likely to produce achlorhydria (complete absence of gastric acid secretion). Clinically significant ...
... as the patients did not have achlorhydria, an inability to produce gastric acid. Furthermore, while patients responded to crude ...
This process is thought to be the most common cause of low B12 in the elderly, who often have some degree of achlorhydria ... Forms of achlorhydria (including that artificially induced by drugs such as proton pump inhibitors and histamine 2 receptor ...
This complex, referred to as the watery diarrhea, hypokalemia and achlorhydria syndrome (VIPoma) has been ascribed to ...
... and can occur even in people who have achlorhydria.[57] ...
However, treatment of these disorders has no known effect in the treatment of achlorhydria. Achlorhydria associated with ... "Achlorhydria." Medscape. Ed. B S. Anand. N.p., 29 Apr. 2015. Web. 25 May 2015. El-Omar EM, Oien K, El-Nujumi A, et al. (1997 ... Achlorhydria may also be documented by measurements of extremely low levels of pepsinogen A (PgA) (< 17 µg/L) in blood serum. ... Achlorhydria resulting from long-term proton-pump inhibitor (PPI) use may be treated by dose reduction or withdrawal of the PPI ...
Achlorhydria - A lack of hydrochloric acid in the digestive juices in the stomach. Hydrochloric acid helps digest food, is ... Medical Word - Achlorhydria. Ans : A lack of hydrochloric acid in the digestive juices in the stomach. Hydrochloric acid helps ... Achlorhydria - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review Team on ...
Achlorhydria and hypochlorhydria is when there is very little, or no gastric acid in the stomach. It can come with other ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Achlorhydria&oldid=4463934" ...
By using the Gastro-Test® we were able to demonstrate that IHN might play a role in both the reduction of achlorhydria-related ... Achlorhydria is a gastrointestinal disorder where the parietal cells no longer function and acid secretion does not occur. We ... Beal CB, Brown JE, A rapid screening test for gastric achlorhydria. Am J Dig Dis 1968;13(2):113-122.. 15. Feldman M, Barnett C ... A pH greater than 3 indicates hypochlorhydria, whereas a pH of 5 or above indicates achlorhydria. This procedure was performed ...
Achlorhydria is the total absence of hydrochloric acid in the digestive juices of the stomach. It can be due to many diverse ... and thus lead to achlorhydria. In addition to treatment of the underlying condition, supplementation with betaine HCL is ...
Achlorhydria indicates the inability to produce gastric acid (i.e., hydrochloric acid [HCl]), even after stimulation with ... Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. J Clin Invest. ... 1995 Sep;109(3):701-6. http://www.ncbi.nlm.nih.gov/pubmed/7657098?tool=bestpractice.com The most common cause of achlorhydria ...
Chlorotic Anemia with Achlorhydria, Splenomegaly, and Small Corpuscular Diameters1 WILLIAM S. MCCANN, M. D.; JANE DYE, A. B. ... MCCANN WS, DYE J. Chlorotic Anemia with Achlorhydria, Splenomegaly, and Small Corpuscular Diameters1. Ann Intern Med. ;4:918- ...
ACHLORHYDRIA A CONSIDERATION OF THE BENEFITS FROM TREATMENT WITH HYDROCHLORIC ACID AND PEPSIN. HERBERT V. DOBSON ... ACHLORHYDRIA A CONSIDERATION OF THE BENEFITS FROM TREATMENT WITH HYDROCHLORIC ACID AND PEPSIN. HERBERT V. DOBSON ... ACHLORHYDRIA A CONSIDERATION OF THE BENEFITS FROM TREATMENT WITH HYDROCHLORIC ACID AND PEPSIN. HERBERT V. DOBSON ... A patient with achlorhydria has been studied by fractional meal tests to determine the effect of giving acid and pepsin. These ...
Reducing peptic ulcer surgeries also give greater protection against Achlorhydria.. Achlorhydria Diagnosis. Nearly 90% of all ... Picture 1 - Achlorhydria. Reduced level of stomach acid can also lead to an overgrowth of bacteria. This may result in diarrhea ... Achlorhydria Prognosis. Not much is known about the possible outcome of this disease. However, there have been some reports of ... A patient of Achlorhydria may suffer from severe stomach pains that are caused by digestion of food not appropriately broken ...
Achlorhydria. Achlorhydria is a condition where there is complete absence or reduced secretion of hydrochloric acid in the ...
The lack of water in the body causes also achlorhydria (strongly reduced secretion of hydrochloric acid) for water constitutes ...
Ferrous Salts (Includes Caltrate 600 with Iron and Vitamin D) ↔ Achlorhydria. Moderate Potential Hazard, Moderate plausibility ...
Achlorhydria-induced malabsorption. *Deficient intake. *Deficient intrinsic factor, a molecule produced by cells in the stomach ...
Persons at increased risk for infection or more severe disease include infants; the elderly; persons with achlorhydria; those ...
Achlorhydria and Cancer Br Med J 1962; 1 :1204 (Published 28 April 1962) ...
Achlorhydria. Bone Diseases, Metabolic. Bone Diseases. Musculoskeletal Diseases. Metabolic Diseases. Femoral Fractures. ...
Achlorhydria. *Gastrinoma. *Zollinger Ellison Syndrome. Observational. *National Institute of Diabetes and Digestive and Kidney ...
Achlorhydria. Vitamin B Deficiency. Avitaminosis. Deficiency Diseases. Malnutrition. Nutrition Disorders. Stomach Diseases. ... Cobalamin Absorption From Fortified Food in Older Adults With and Without Proton Pump Inhibitor Induced Achlorhydria. ... in which gastric atrophy/achlorhydria and/or dysfunction is implicated. Because of the prevalence of deficiency in those over ... from 14C-B12 fortified bread in healthy subjects and in subjects with proton pump inhibitor induced achlorhydria. ...
Achlorhydria, Parietal Cell Hyperplasia, and Multiple Gastric Carcinoids: A New Disorder?. Waldum, Helge L.; Qvigstad, Gunnar ...
Calcium absorption and achlorhydria. N Engl J Med 1985; 313: 70.PubMedCrossRefGoogle Scholar ...
Achrestic Anaemia with Achlorhydria Br Med J 1944; 1 :184 (Published 05 February 1944) ...
Achlorhydria. The complete absence or failure of stomach acid secretion.. Helicobacter Pylori. H. pylori is a bacterium that is ...
Achlorhydria. Achlorhydria is a stomach condition where there is no gastric acid in the stomach secretions. Hypochlorhydria is ...
The Clinical Importance of Achlorhydria Br Med J 1935; 1 :81 (Published 12 January 1935) ...
Achlorhydria, 74, 142. Adenylate cyclase, 191. Adequate Intakes (AIs), see also Calcium AIs; ...
  • The consequences of hypo- and achlorhydria include an increased susceptibility to gastric bacterial overgrowth, 1 enteric infections, 2,3 hypergastrinemia that might lead to enterochromaffin-like cell hyperplasia and neoplasia, 4-7 and malabsorption of various nutrients (e.g., calcium, iron and zinc) and amino acids. (townsendletter.com)
  • About 40% of older persons with low serum cobalamin have food cobalamin malabsorption (F-CM), in which gastric atrophy/achlorhydria and/or dysfunction is implicated. (clinicaltrials.gov)
  • http://www.ncbi.nlm.nih.gov/pubmed/18474247?tool=bestpractice.com Brand SJ, Stone D. Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. (bmj.com)
  • Thus somatostatinomas are associated with mild diabetes mellitus (due to inhibition of insulin release), steatorrhoea and gallstones (due to inhibition of cholecystokinin release), and achlorhydria (due to inhibition of gastrin release). (wikipedia.org)
  • Dr. Rahbar - Heidelberg pH Testing" section The Heidelberg Diagnostic test is used to diagnose Hypochlorhydria (reduced acid production), Hyperchlorhydria (excessive acid production), Achlorhydria (no acid production), Pyloric Insufficiency, Heavy Stomach Mucus (from infection or ulceration), Acute and Sub-acute Gastritis. (wikipedia.org)
  • He was surprised when, only three days later, he developed vague nausea and halitosis (due to the achlorhydria, there was no acid to kill bacteria in the stomach, and their waste products manifested as bad breath), noticed only by his mother. (wikipedia.org)
  • To determine B12 bioavailability from 14C-B12 fortified bread in healthy subjects and in subjects with proton pump inhibitor induced achlorhydria. (clinicaltrials.gov)
  • Presents with abdominal pain and edema For practical purposes, gastric pH an endoscopy should be done in someone with suspected achlorhydria. (wikipedia.org)